WorldWideScience

Sample records for mode pim time

  1. Tuning procedure for the Linac4 PI Mode Structure(PIMS)

    CERN Document Server

    Ugena Tirado, P

    2012-01-01

    PI-Mode-Structure (PIMS) cavities will be used in the high energy section of LINAC4 (102-160 MeV). Each cavity is made of 7 coupled cells, operated in the π-mode at a resonant frequency of 352.2 MHz. The cell length remains constant for each of the 12 cavities but changes from cavity to cavity to synchronise with the increased beam energy. This paper reports on the tuning process required to get a constant voltage in each cell at the resonant frequency which consists of re-machining to the required level the tuning rings located on each cell-wall. An algorithm based on single cell detuning, equivalent circuit simulations and precise 3D simulations for the 3 different cell types of each cavity has been developed and successfully applied to the tuning of the first PIMS cavity. In order to reduce the simulation effort for the remaining 11 cavities, an interpolation algorithm based on 3 cavities has been developed and validated. In a second tuning step, after the electron beam welding of all elements, the final ...

  2. Time of flight in MUSE at PIM1 at Paul Scherrer Institute

    Science.gov (United States)

    Lin, Wan; Gilman, Ronald; MUSE Collaboration

    2016-09-01

    The MUSE experiment at PIM1 at Paul Scherrer Institute in Villigen, Switzerland, measures elastic scattering of electrons and muons from a liquid hydrogen target. The intent of the experiment is to deduce whether the radius of the proton is the same when determined from the two different particle types. Precision timing is an important aspect of the experiment, used to determine particle types, reaction types, and beam momentum. Here we present results for a test setup measuring time of flight between prototypes of two detector systems to be used in the experiment, compared to Geant4 simulations. The results demonstrate time of flight resolution better than 100 ps, and beam momentum determination at the level of a few tenths of a percent. Douglass Project for Rutgers Women in Math, Science & Engineering, National Science Foundation Grant 1306126 to Rutgers University.

  3. Sudan PIMS

    Data.gov (United States)

    US Agency for International Development — The development of this system was awarded to MSI in May 2013 to design and help USAID/South Sudan manage a web-based PIMS that is customized to USAID/South Sudan's...

  4. Time of flight and the MUSE experiment in the PIM1 Channel at the Paul Sherrer Institute

    Science.gov (United States)

    Lin, Wan; MUSE Collaboration

    2015-10-01

    The MUSE experiment in the PIM1 Channel at the Paul Sherrer Institute in Villigen, Switzerland, measures scattering of electrons and muons from a liquid hydrogen target. The intent of the experiment is to deduce from the scattering probabilities whether the radius of the proton is the same when determined from the scattering of the two different particle types. An important technique for the experiment is precise timing measurements, using high precision scintillators and a beam Cerenkov counter. We will describe the motivations for the precise timing measurement. We will present results for the timing measurements from prototype experimental detectors. We will also present results from a simulation program, Geant4, that was used to calculate energy loss corrections to the time of flight determined between the beam Cherenkov counter and the scintillator. This work is supported in part by the U.S. National Science Foundation Grant PHY 1306126 and the Douglass Project for Women in Math, Science, and Engineering.

  5. South Africa PIMS

    Data.gov (United States)

    US Agency for International Development — PIMS (SOL-674-12-000037) collects and provides information on activities, results, partners, and staff supported through PEPFAR funding in each sub-district of South...

  6. Time-resolved multi-mass ion imaging: Femtosecond UV-VUV pump-probe spectroscopy with the PImMS camera

    Science.gov (United States)

    Forbes, Ruaridh; Makhija, Varun; Veyrinas, Kévin; Stolow, Albert; Lee, Jason W. L.; Burt, Michael; Brouard, Mark; Vallance, Claire; Wilkinson, Iain; Lausten, Rune; Hockett, Paul

    2017-07-01

    The Pixel-Imaging Mass Spectrometry (PImMS) camera allows for 3D charged particle imaging measurements, in which the particle time-of-flight is recorded along with (x, y) position. Coupling the PImMS camera to an ultrafast pump-probe velocity-map imaging spectroscopy apparatus therefore provides a route to time-resolved multi-mass ion imaging, with both high count rates and large dynamic range, thus allowing for rapid measurements of complex photofragmentation dynamics. Furthermore, the use of vacuum ultraviolet wavelengths for the probe pulse allows for an enhanced observation window for the study of excited state molecular dynamics in small polyatomic molecules having relatively high ionization potentials. Herein, preliminary time-resolved multi-mass imaging results from C2F3I photolysis are presented. The experiments utilized femtosecond VUV and UV (160.8 nm and 267 nm) pump and probe laser pulses in order to demonstrate and explore this new time-resolved experimental ion imaging configuration. The data indicate the depth and power of this measurement modality, with a range of photofragments readily observed, and many indications of complex underlying wavepacket dynamics on the excited state(s) prepared.

  7. Photodynamic immune modulation (PIM)

    Science.gov (United States)

    North, John R.; Hunt, David W. C.; Simkin, Guillermo O.; Ratkay, Leslie G.; Chan, Agnes H.; Lui, Harvey; Levy, Julia G.

    1999-09-01

    Photodynamic Therapy (PDT) is accepted for treatment of superficial and lumen-occluding tumors in regions accessible to activating light and is now known to be effective in closure of choroidal neovasculature in Age Related Macular Degeneration. PDT utilizes light absorbing drugs (photosensitizers) that generate the localized formation of reactive oxygen species after light exposure. In a number of systems, PDT has immunomodulatory effects; Photodynamic Immune Modulation (PIM). Using low- intensity photodynamic regimens applied over a large body surface area, progression of mouse autoimmune disease could be inhibited. Further, this treatment strongly inhibited the immunologically- medicated contact hypersensitivity response to topically applied chemical haptens. Immune modulation appears to result from selective targeting of activated T lymphocytes and reduction in immunostimulation by antigen presenting cells. Psoriasis, an immune-mediated skin condition, exhibits heightened epidermal cell proliferation, epidermal layer thickening and plaque formation at different body sites. In a recent clinical trial, approximately one-third of patients with psoriasis and arthritis symptoms (psoriatic arthritis) displayed a significant clinical improvement in several psoriasis-related parameters after four weekly whole-body PIM treatments with verteporfin. The safety profile was favorable. The capacity of PIM to influence other human immune disorders including rheumatoid arthritis is under extensive evaluation.

  8. 2D PIM Simulation Based on COMSOL

    DEFF Research Database (Denmark)

    Wang, Xinbo; Cui, Wanzhao; Wang, Jingyu;

    2011-01-01

    Passive intermodulation (PIM) is a problematic type of nonlinear distortion en- countered in many communication systems. To analyze the PIM distortion resulting from ma- terial nonlinearity, a 2D PIM simulation method based on COMSOL is proposed in this paper. As an example, a rectangular wavegui...

  9. Argon metastables in HiPIMS: validation of the ionization region model by direct comparison to time resolved tunable diode-laser diagnostics

    Science.gov (United States)

    Stancu, G. D.; Brenning, N.; Vitelaru, C.; Lundin, D.; Minea, T.

    2015-08-01

    The volume plasma interactions of high power impulse magnetron sputtering (HiPIMS) discharges operated with a Ti target is analyzed in detail by combining time-resolved diagnostics with modeling of plasma kinetics. The model employed is the ionization region model (IRM) with an improved and detailed treatment of the kinetics of the argon metastable (Arm) state, called m-IRM. The diagnostics used is tunable diode-laser absorption spectroscopy (TD-LAS) of the Arm state, which gives the line-of-sight density integrated along the laser path parallel to the target surface. The TD-LAS recordings exhibit quite complex temporal evolutions Arm(t), with distinct features that are shown to reflect the time evolution of the plasma (the electron density and temperature), and of the argon gas (gas rarefaction and refill). The Arm(t) function is thus a tracer for the most important aspects of internal discharge physics, and therefore suitable for model testing and validation. The IRM model is constructed to be locked to obey specific experimental macroscopic discharge parameters, specifically the discharge current ID(t) and the voltage UD(t). It has to this purpose been run with the appropriate process gas pressures (from 0.67 to 2.67 Pa), with the experimentally applied voltage pulse profiles UD(t), and with the resulting current pulse profiles ID(t) (with maxima from 0.5 to 70 A). It is shown that the model reproduces the features in the TD-LAS measurements: both the Arm(t) evolution in single pulses, and how the pulse shapes change with gas pressure and with pulse amplitude. The good agreement between the measurements and model output is in this work taken to validate the basic assumptions of the m-IRM. In addition, the m-IRM results have been used to unravel the connections between volume plasma kinetics and various features recorded in the TD-LAS measurement, and to generalize the foremost characteristics of the studied discharges.

  10. Application of PIMS Software in Monthly Planning of Refinery Production

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    This article describes the application of the PIMS software in formulating monthly refining production plan. Application of the PIMS software can help to solve a series of problems related with monthly plan of refining production such as optimized selection of crude and feedstocks, optimized selection of production scale and processing scheme, identification of bottlenecks and their mitigation,optimized selection of turnaround time and optimized selection of operating regime, which have increased the economic benefits of refining enterprises. With the further development and improvement of models the PIMS software will play an increasingly important role in formulating monthly plans of refining operations and production management at refineries. This article also explores the problems existing in refinery monthly planning, and has made recommendations on developing and improving models and reporting system, enhancement of basic data acquisition, model maintenance personnel and staff training.

  11. Discrete-time nonlinear sliding mode controller

    African Journals Online (AJOL)

    user

    : Discrete-time delay system, Sliding mode control, nonlinear sliding ... The concept of the sliding mode control in recent years has drawn the ...... His area of interest is dc-dc converters, electrical vehicle and distributed generation application.

  12. The Performance of a Thermally Cross-Linked Polymer of Intrinsic Microporosity (PIM-1) for Gas Separation

    KAUST Repository

    Alghunaimi, Fahad I.

    2013-05-01

    Gas transport properties of PIM-1 (the first ladder polymer with intrinsic microporosity) and TC-PIM-1 (thermally cross-linked PIM-1) at 35°C and different pressures were thoroughly studied. The purpose of this study was to evaluate and compare the performance of the TC-PIM-1 membranes with PIM-1 for natural gas separation. The TC-PIM-1 polymer was prepared by post-modification of PIM-1 at 300°C for a period of two days. Sorption isotherms of seven gases, including N2, O2, CH4, CO2, C2H6, C3H8 and n-C4H10, were determined for PIM-1 and TC-PIM-1 using the dual-volume barometric sorption technique at 35°C at different pressures. The sorption isotherms followed the dual-mode sorption model, which is typical for glassy polymers. Moreover, permeability (P) of eight gases, including He, H2, N2, O2, CH4, CO2, C3H8 and n-C4H10, were determined for PIM-1 and TC-PIM-1 at 35°C and 2.0 atm. Furthermore, average diffusion coefficients (D ̅) were calculated from the permeability and solubility data for all tested gases for both polymers. The sorption (S), permeability (P) and average diffusion coefficients (D ̅) for the TC-PIM-1 membrane exhibited lower values than the PIM-1 membrane. However, the TC-PIM-1 membrane showed exceptional gas separation performance. The TC-PIM-1 membrane had a helium (He) permeability of 1218 barrer with He/CH4 and He/N2 ideal selectivities of 27.1 and 23.9 respectively, and carbon dioxide (CO2) permeability of 1088 barrer with CO2/CH4 and CO2/N2 ideal selectivities of 24.2 and 21.3 respectively. Additionally, the TC-PIM-1 membrane showed a hydrogen (H2) permeability of 2452 barrer with an ideal H2/CH4 selectivity of 54.5.

  13. Targeting the Pim kinases in multiple myeloma.

    LENUS (Irish Health Repository)

    Keane, N A

    2015-07-17

    Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine\\/threonine kinases with increased expression across the hematological malignancies. Pim-2 shows highest expression in MM and constitutes a promising therapeutic target. It is upregulated by the bone marrow microenvironment to mediate proliferation and promote MM survival. Pim-2 also has a key role in the bone destruction typically seen in MM. Additional putative roles of the Pim kinases in MM include trafficking of malignant cells, promoting oncogenic signaling in the hypoxic bone marrow microenvironment and mediating resistance to therapy. A number of Pim inhibitors are now under development with lead compounds entering the clinic. The ATP-competitive Pim inhibitor LGH447 has recently been reported to have single agent activity in MM. It is anticipated that Pim inhibition will be of clinical benefit in combination with standard treatments and\\/or with novel drugs targeting other survival pathways in MM.

  14. Personal Information Management (PIM: an Introduction

    Directory of Open Access Journals (Sweden)

    Rasoul Zavaraqi

    2012-10-01

    Full Text Available The aim of this paper was to present detailed texts about necessities of personal information management (PIM and has been written by literature survey. Historical investigation of this new born research area showed PIM is an extension to primary personal information management in offices and other bureaucratic centers. PIM is the result of new ICT developments and its followings as information overload and pollution, which is combination of information retrieval, database management systems (DBMS, information science, human-computer interaction, cognitive psychology, and artificial intelligence. The research area tries to address to old challenges by new mechanisms. The paper introduced the new born research area and discussed about its appearance, definitions, history, benefits, performance and researches which has been done about it.

  15. Lymphoma induction by heterocyclic amines in Eu-pim-1 transgenic mice

    DEFF Research Database (Denmark)

    Sørensen, Ilona Kryspin; Kristiansen, E.; Mortensen, Alicja

    1997-01-01

    The usefulness of transgenic E mu-pim-1 mice bearing in their genome the pim-1 oncogene supplemented with an upstream immunoglobulin enhancer and a downstream murine leukaemia virus long terminal repeat, as sensitive test organisms was studied in two short-term carcinogenicity studies. The mice...... to bacteria and cultured mammalian cells. PhIP is a potent mouse lymphomagen, while IQ is a liver, lung and forestomach carcinogen in mice. We found that transgenic E mu-pim-1 mice are highly susceptible to PhIP induced lymphomagenesis but do not respond to IQ treatment. PhIP feeding of E mu-pim-1 mice...... not only increased the total number of T-cell lymphomas but also decreased the latency time compared to either transgenic or wild-type controls. The effect was most pronounced in the treated female E mu-pim-1 mice, which showed a higher incidence of PhIP induced T-cell lymphomas than transgenic males...

  16. Building more powerful less expensive supercomputers using Processing-In-Memory (PIM) LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, Richard C.

    2009-09-01

    This report details the accomplishments of the 'Building More Powerful Less Expensive Supercomputers Using Processing-In-Memory (PIM)' LDRD ('PIM LDRD', number 105809) for FY07-FY09. Latency dominates all levels of supercomputer design. Within a node, increasing memory latency, relative to processor cycle time, limits CPU performance. Between nodes, the same increase in relative latency impacts scalability. Processing-In-Memory (PIM) is an architecture that directly addresses this problem using enhanced chip fabrication technology and machine organization. PIMs combine high-speed logic and dense, low-latency, high-bandwidth DRAM, and lightweight threads that tolerate latency by performing useful work during memory transactions. This work examines the potential of PIM-based architectures to support mission critical Sandia applications and an emerging class of more data intensive informatics applications. This work has resulted in a stronger architecture/implementation collaboration between 1400 and 1700. Additionally, key technology components have impacted vendor roadmaps, and we are in the process of pursuing these new collaborations. This work has the potential to impact future supercomputer design and construction, reducing power and increasing performance. This final report is organized as follow: this summary chapter discusses the impact of the project (Section 1), provides an enumeration of publications and other public discussion of the work (Section 1), and concludes with a discussion of future work and impact from the project (Section 1). The appendix contains reprints of the refereed publications resulting from this work.

  17. Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

    NARCIS (Netherlands)

    Mikkers, H; Nawijn, M; Allen, J; Brouwers, C; Verhoeven, E; Jonkers, J; Berns, A

    2004-01-01

    The Pim family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. Although the Pim genes are evolutionarily highly conserved, the contribution of PIM proteins to mammalian development is unclear. PIM1-deficient mice were previously described b

  18. Gas Sorption, Diffusion and Permeation in a Polymer of Intrinsic Microporosity (PIM-7)

    KAUST Repository

    Alaslai, Nasser Y.

    2013-05-08

    The entire world including Saudi Arabia is dependent on natural gas to provide new energy supplies for the future. Conventional ways for gas separation are expensive, and, hence, it is very important to reduce the cost and lower the energy consumption. Membrane technology is a relatively new separation process for natural gas purification with large growth potential, specifically for off-shore applications. The economics of any membrane separation process depend primarily on the intrinsic gas permeation properties of the membrane materials. All current commercial membranes for natural gas separation are made from polymers, which have several drawbacks, including low permeability, moderate selectivity, and poor stability in acid gas and hydrocarbon environments. The recent development of polymeric materials called “polymers of intrinsic microporosity” (PIMs) provide a new class of high-performance membrane materials that are anticipated to be used in natural gas separation processes including, but not limited to, acid gas removal and separation of hydrocarbons from methane. PIM-7 is an excellent example of a material from the PIMs series for gas separation. It was selected for this work since it has not been extensively tested for its gas permeation properties to date. Specifically, sorption and mixed-gas permeation data were not available for PIM-7 prior to this work. Sorption isotherms of N2, O2, CH4, CO2, C2H6, C3H8 and n-C4H10 were determined over a range of pressures at 35 oC for PIM-7 using a custom-designed dual-volume pressure decay system. Condensable hydrocarbon gases, such as C3H8 and n-C4H10, show significantly higher solubility than the other less condensable gas of the test series due to their high affinity to the polymer matrix. Dual-mode sorption model parameters were determined from the sorption isotherms. Henry’s law solubility, Langmuir capacity constant and the affinity constant increased with gas condensability. Permeability coefficients

  19. An introduction to the new Productivity Information Management System (PIMS)

    Science.gov (United States)

    Hull, R.

    1982-01-01

    The productivity information management system (PIMS), is described. The main objective of this computerized system is to enable management scientists to interactively explore data concerning DSN operations, maintenance and repairs, to develop and verify models for management planning. The PIMS will provide a powerful set of tools for iteratively manipulating data sets in a wide variety of ways. The initial version of PIMS will be a small scale pilot system. The following topics are discussed: (1) the motivation for developing PIMS; (2) various data sets which will be integrated by PIMS; (3) overall design of PIMS; and (4) how PIMS will be used. A survey of relevant databases concerning DSN operations at Goldstone is also included.

  20. An introduction to the Gilgamesh PIM architecture

    Science.gov (United States)

    Sterling, T.; Bergman, L.

    2001-01-01

    The focus of the work conducted is on a class of structures made possible by the merger of logic and memory. Processing In Memory (PIM) extends the design space much farther by closely associating the logic with the memory interface to realize innovative structures never previously possible and thus exposing entirely new opportunities for computer architecture.

  1. PIMS-Universal Payload Information Management

    Science.gov (United States)

    Elmore, Ralph; McNair, Ann R. (Technical Monitor)

    2002-01-01

    As the overall manager and integrator of International Space Station (ISS) science payloads and experiments, the Payload Operations Integration Center (POIC) at Marshall Space Flight Center had a critical need to provide an information management system for exchange and management of ISS payload files as well as to coordinate ISS payload related operational changes. The POIC's information management system has a fundamental requirement to provide secure operational access not only to users physically located at the POIC, but also to provide collaborative access to remote experimenters and International Partners. The Payload Information Management System (PIMS) is a ground based electronic document configuration management and workflow system that was built to service that need. Functionally, PIMS provides the following document management related capabilities: 1. File access control, storage and retrieval from a central repository vault. 2. Collect supplemental data about files in the vault. 3. File exchange with a PMS GUI client, or any FTP connection. 4. Files placement into an FTP accessible dropbox for pickup by interfacing facilities, included files transmitted for spacecraft uplink. 5. Transmission of email messages to users notifying them of new version availability. 6. Polling of intermediate facility dropboxes for files that will automatically be processed by PIMS. 7. Provide an API that allows other POIC applications to access PIMS information. Functionally, PIMS provides the following Change Request processing capabilities: 1. Ability to create, view, manipulate, and query information about Operations Change Requests (OCRs). 2. Provides an adaptable workflow approval of OCRs with routing through developers, facility leads, POIC leads, reviewers, and implementers. Email messages can be sent to users either involving them in the workflow process or simply notifying them of OCR approval progress. All PIMS document management and OCR workflow controls are

  2. Real-time Detection of Locked Modes

    Science.gov (United States)

    Angelini, S.; Granetz, R. S.; Wolfe, S. M.

    2007-11-01

    Disruptions are one of the largest problems facing tokamaks. In a large-scale experiment such as ITER, disruptions would cause crippling damage and severe setbacks in experimentation. One method for disruption mitigation involves the use of a gas jet which has been tested on both normally running plasmas and vertical displacement events (VDEs) on Alcator C-Mod. In both cases, the jet was successful in mitigating disruption effects. The gas jet has not yet been tested on other types of disruptions. Locked-mode major disruptions are easily created in C-Mod and could be used to test the effectiveness of the gas jet as a mitigation method if the jet could be fired early enough. It has been empirically observed that the electron cyclotron emissions (ECE) signal displays a flattening of the normally-present sawteeth before the current quench occurs in certain locked-mode major disruptions. A procedure is being written which will detect the ECE flattening by reading changes in the standard deviation of the signal. This procedure will be programmed into the digital plasma control system (DPCS) for real-time testing.

  3. Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

    Directory of Open Access Journals (Sweden)

    Prudhomme Michelle

    2010-10-01

    Full Text Available Abstract Background Pim family kinases are small constitutively active serine/threonine-specific kinases, elevated levels of which have been detected in human hematopoietic malignancies as well as in solid tumours. While we and others have previously shown that the oncogenic Pim kinases stimulate survival of hematopoietic cells, we now examined their putative role in regulating motility of adherent cancer cells. For this purpose, we inhibited Pim kinase activity using a small molecule compound, 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde (DHPCC-9, which we had recently identified as a potent and selective inhibitor for all Pim family members. Results We now demonstrate that the Pim kinase inhibitor DHPCC-9 is very effective also in cell-based assays. DHPCC-9 impairs the anti-apoptotic effects of Pim-1 in cytokine-deprived myeloid cells and inhibits intracellular phosphorylation of Pim substrates such as Bad. Moreover, DHPCC-9 slows down migration and invasion of cancer cells derived from either prostate cancer or squamocellular carcinoma patients. Silencing of Pim expression reduces cell motility, while Pim overexpression enhances it, strongly suggesting that the observed effects of DHPCC-9 are dependent on Pim kinase activity. Interestingly, DHPCC-9 also abrogates NFATc-dependent migration of cancer cells, implying that NFATc factors mediate at least part of the pro-migratory effects of Pim kinases. Conclusions Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells.

  4. Inhibition of the Pim1 oncogene results in diminished visual function.

    Directory of Open Access Journals (Sweden)

    Jun Yin

    Full Text Available Our objective was to profile genetic pathways whose differential expression correlates with maturation of visual function in zebrafish. Bioinformatic analysis of transcriptomic data revealed Jak-Stat signalling as the pathway most enriched in the eye, as visual function develops. Real-time PCR, western blotting, immunohistochemistry and in situ hybridization data confirm that multiple Jak-Stat pathway genes are up-regulated in the zebrafish eye between 3-5 days post-fertilisation, times associated with significant maturation of vision. One of the most up-regulated Jak-Stat genes is the proto-oncogene Pim1 kinase, previously associated with haematological malignancies and cancer. Loss of function experiments using Pim1 morpholinos or Pim1 inhibitors result in significant diminishment of visual behaviour and function. In summary, we have identified that enhanced expression of Jak-Stat pathway genes correlates with maturation of visual function and that the Pim1 oncogene is required for normal visual function.

  5. Mode choice endogeneity in value of travel time estimation

    DEFF Research Database (Denmark)

    Mabit, Stefan Lindhard; Fosgerau, Mogens

    The current way to estimate value of travel time is to use a mode-specific sample and hence to estimate mode-specific value of travel times. This approach raises certain questions concerning how to generalise the values to a population. A problem would be if there is an uncontrolled sample...... selection mechanism. This is the case if there is correlation between mode choice and the value of travel time that is not controlled for by explanatory variables. What could confuse the estimated values is the difficulty to separate mode effects from user effect. An example would be the effect of income...... of travel time we use a stated choice dataset. These data include binary choice within mode for car and bus. The first approach is to use a probit model to model mode choice using instruments and then use this in the estimation of the value of travel time. The second approach is based on the use of a very...

  6. Analysis of acoustic radiation mode in time domain

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The acoustic radiation mode of plane, whose radiating operator is constructed by Rayleigh integral, is investigated in the time domain and its physical meaning is given. The relationship between the acoustic radiation modes of time domain and frequency domain is discussed. It is verified that the acoustic radiation modes are the natural property of the radiator and they can be obtained by different methods. These time domain radiation modes, whose shapes are only dependent on the geometry size and shape of the radiator, can radiate sound power independently. Especially, the first time domain radiation mode accounts for most of the sound radiation. All these simplify the calculation and control of the structure-borne sound power. Based on these observations, the sound power radiated from the vibrating plate is estimated by the time domain radiation mode for verifying the proposed method. The influence factors on the estimating accuracy in different conditions are discussed.

  7. How Do Organic Vapors Swell Ultra-Thin PIM-1 Films?

    KAUST Repository

    Ogieglo, Wojciech

    2017-06-22

    Dynamic sorption of ethanol and toluene vapor into ultra-thin supported PIM-1 films down to 6 nm are studied with a combination of in-situ spectroscopic ellipsometry and in-situ X-ray reflectivity. Both ethanol and toluene significantly swell the PIM-1 matrix and, at the same time, induce persistent structural relaxations of the frozen-in glassy PIM-1 morphology. For ethanol below 20 nm three effects were identified. First, the swelling magnitude at high vapor pressures is reduced by about 30% as compared to thicker films. Second, at low penetrant activities (below 0.3 p/p0) films below 20 nm are able to absorb slightly more penetrant as compared with thicker films despite similar swelling magnitude. Third, for the ultra-thin films the onset of the dynamic penetrant-induced glass transition Pg has been found to shift to higher values indicating higher resistance to plasticization. All of these effects are consistent with a view where immobilization of the super-glassy PIM-1 at the substrate surface leads to an arrested, even more rigid and plasticization-resistant, yet still very open, microporous structure. PIM-1 in contact with the larger and more condensable toluene shows very complex, heterogeneous swelling dynamics and two distinct penetrant-induced relaxation phenomena, probably associated with the film outer surface and the bulk, are detected. Following the direction of the penetrant\\'s diffusion the surface seems to plasticize earlier than the bulk and the two relaxations remain well separated down to 6 nm film thickness, where they remarkably merge to form just a single relaxation.

  8. Clinical and biological significance of PIM1 kinase in osteosarcoma.

    Science.gov (United States)

    Liao, Yunfei; Feng, Yong; Shen, Jacson; Gao, Yan; Cote, Gregory; Choy, Edwin; Harmon, David; Mankin, Henry; Hornicek, Francis; Duan, Zhenfeng

    2016-07-01

    Osteosarcoma is the most prevalent histological form of primary malignant bone tumor. The majority of osteosarcoma patients have limited alternative therapeutic options and metastatic patients generally have a poor prognosis. Proto-oncogene serine/threonine-protein kinase PIM1 is associated with growth and survival of many kinds of tumor cells. However, the role of PIM1 in osteosarcoma remains largely unknown. In this study, we investigated the functional and therapeutic relevance of PIM1 as a putative target in osteosarcoma. We found PIM1 was highly expressed in various osteosarcoma cell lines and in tumor tissues from osteosarcoma patients. Tissue microarray and immunohistochemistry analysis showed that the overall and disease-free survival rate of patients with high levels of PIM1 protein expression were significantly shorter than patients with low levels. High levels of PIM1 were also associated with present metastasis and can be considered as an independent prognostic factor in osteosarcoma patients. Knockdown of PIM1 expression by synthetic siRNA or shRNA greatly inhibited cell growth, migration, and invasion. Moreover, these changes accompanied with down-regulation of anti-apoptotic protein Bcl-2. The similar results were obtained in osteosarcoma cells treated with PIM1 specific inhibitor (SMI-4a). These results suggest that PIM1 kinase is critical for the growth and metastasis of osteosarcoma cells and can be a potential therapeutic target for osteosarcoma treatment. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1185-1194, 2016. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  9. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

    OpenAIRE

    Amson, R; Sigaux, F; Przedborski, S; Flandrin, G; Givol, D; Telerman, A

    1989-01-01

    We measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies. Our data indicate that during human fetal hematopoiesis the 33-kDa pim product, p33pim, is highly expressed in the liver and spleen. In contrast, at the adult stage it is only slightly expressed in circulating granulocytes. Out of 70 hematopoietic malignancies analyzed, 51 patients and 19 cell lines, p33pim was overexpressed in approximately 30% of the samples, particularly i...

  10. Timing characterization of 100 GHz passively mode-locked discrete mode laser diodes

    CERN Document Server

    Bitauld, David; O'Brien, Stephen

    2011-01-01

    We report on the characterization of the timing stability of passively mode-locked discrete mode diode laser sources. These are edge-emitting devices with a spatially varying refractive index profile for spectral filtering. Two devices with a mode-locking frequency of 100 GHz are characterized. The first device is designed to support a comb of six modes and generates near Fourier limited 1.9 ps pulses. The second supports four primary modes resulting in a sinusoidal modulation of the optical intensity. Using a cross-correlation technique, we measured a 20 fs pulse to pulse timing jitter for the first device, while, for the second device, a mode-beating (RF) linewidth of 1 MHz was measured using heterodyne mixing in a semiconductor optical amplifier. Comparison of these results with those obtained for an equivalent Fabry-Perot laser indicates that the spectral filtering mechanism employed does not adversely affect the timing properties of these passively mode-locked devices.

  11. Analysis of acoustic radiation mode in time domain

    Institute of Scientific and Technical Information of China (English)

    WU WeiGuo

    2009-01-01

    The acoustic radiation mode of plane,whose radiating operator is constructed by Rayleigh integral,is Investigated in the time domain and its physical meaning is given.The relationship between the acoustic radiation modes of time domain end frequency domain is discussed.It is verified that the acoustic radiation modes are the natural property of the radiator and they can be obtained by different methods.These time domain radiation modes,whose shapes are only dependent on the geometry size and shape of the radiator,can radiate sound power independently.Especially,the first time domain radiation mode accounts for most of the sound radiation.All these simplify the calculation and control of the structure-borne sound power.Based on these observations,the sound power radiated from the vibrating plate is estimated by the time domain radiation mode for verifying the proposed method.The influence factors on the estimating accuracy in different conditions are discussed.

  12. Finite time convergent control using terminal sliding mode

    Institute of Scientific and Technical Information of China (English)

    Yiguang HONG; Guowu YANG; Daizhan CHENG; Sarah SPURGEON

    2004-01-01

    A method for terminal sliding mode control design is discussed. As we know, one of the strong points of terminal sliding mode control is its finite-time convergence to a given equilibrium of the system under consideration, which may be useful in specific applications. The proposed method, different from many existing terminal sliding model control design methods, is studied, and then feedback laws are designed for a class of nonlinear systems, along with illustrative examples.

  13. Time-Frequency Analysis of the Dispersion of Lamb Modes

    Science.gov (United States)

    Prosser, W. H.; Seale, Michael D.; Smith, Barry T.

    1999-01-01

    Accurate knowledge of the velocity dispersion of Lamb modes is important for ultrasonic nondestructive evaluation methods used in detecting and locating flaws in thin plates and in determining their elastic stiffness coefficients. Lamb mode dispersion is also important in the acoustic emission technique for accurately triangulating the location of emissions in thin plates. In this research, the ability to characterize Lamb mode dispersion through a time-frequency analysis (the pseudo Wigner-Ville distribution) was demonstrated. A major advantage of time-frequency methods is the ability to analyze acoustic signals containing multiple propagation modes, which overlap and superimpose in the time domain signal. By combining time-frequency analysis with a broadband acoustic excitation source, the dispersion of multiple Lamb modes over a wide frequency range can be determined from as little as a single measurement. In addition, the technique provides a direct measurement of the group velocity dispersion. The technique was first demonstrated in the analysis of a simulated waveform in an aluminum plate in which the Lamb mode dispersion was well known. Portions of the dispersion curves of the A(sub 0), A(sub 1), S(sub 0), and S(sub 2)Lamb modes were obtained from this one waveform. The technique was also applied for the analysis of experimental waveforms from a unidirectional graphite/epoxy composite plate. Measurements were made both along, and perpendicular to the fiber direction. In this case, the signals contained only the lowest order symmetric and antisymmetric modes. A least squares fit of the results from several source to detector distances was used. Theoretical dispersion curves were calculated and are shown to be in good agreement with experimental results.

  14. Recent advances in PIM technology I

    Directory of Open Access Journals (Sweden)

    Zlatkov B.S.

    2008-01-01

    Full Text Available In this article the state of art of the PIM (Powder Injection Moulding technology is given in brief. The main process flow diagram consisting of four steps: feedstock preparation, injection moulding (green samples forming, the debinding (binder removing procedure and the sintering process was described. After that the materials for binders and additives for the surface active agents were mentioned in brief. The metal injection moulding (MIM process was analysed in more detail: MIM- stainless steels, MIM-copper and MIM-aluminium as the most metals common in MIM metal parts production. After that our results of MIM stainless steel 316 L and MIM copper are given. The main powder characteristics, the shrinkage and density of the sintered samples were compared for isostatically pressed PM (powder metallurgy samples and MIM formed samples. The SEM fractographs of MIM and PM samples are given for MIM green parts, debinded (brown parts and sintered parts, and PM green parts and sintered parts. The results obtained were compared with literature data before they were applied in metal parts production.

  15. Cardiac Time Intervals by Tissue Doppler Imaging M-Mode

    DEFF Research Database (Denmark)

    Biering-Sørensen, Tor; Mogelvang, Rasmus; de Knegt, Martina Chantal;

    2016-01-01

    PURPOSE: To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining...... MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function. METHODS: In a large community based population study (n = 974), where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic...... the MPITDI and MPIConv measured. RESULTS: IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (pcardiac function. MPITDI...

  16. The Plasma Instrument for Magnetic Sounding (PIMS) for the Europa Mission

    Science.gov (United States)

    Westlake, J. H.; McNutt, R. L.; Kasper, J. C.; Case, A. W.; Rymer, A. M.; Stevens, M. L.; Jia, X.; Paty, C.; Khurana, K. K.; Kivelson, M. G.; Slavin, J. A.; Smith, H. T.; Korth, H.; Krupp, N.; Roussous, E.; Saur, J.

    2016-10-01

    We present the Plasma Instrument for Magnetic Sounding (PIMS) selected for the Europa Mission. We specifically address how PIMS plasma measurements will improve the accuracy of magnetic sounding of Europa's subsurface ocean.

  17. Finite-Time Reentry Attitude Control Using Time-Varying Sliding Mode and Disturbance Observer

    OpenAIRE

    Xuzhong Wu; Shengjing Tang; Jie Guo; Yao Zhang

    2015-01-01

    This paper presents the finite-time attitude control problem for reentry vehicle with redundant actuators in consideration of planet uncertainties and external disturbances. Firstly, feedback linearization technique is used to cancel the nonlinearities of equations of motion to construct a basic mode for attitude controller. Secondly, two kinds of time-varying sliding mode control methods with disturbance observer are integrated with the basic mode in order to enhance the control performance ...

  18. Reusable Launch Vehicle Control In Multiple Time Scale Sliding Modes

    Science.gov (United States)

    Shtessel, Yuri; Hall, Charles; Jackson, Mark

    2000-01-01

    A reusable launch vehicle control problem during ascent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust, de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues placement. Overall stability of a two-loop control system is addressed. An optimal control allocation algorithm is designed that allocates torque commands into end-effector deflection commands, which are executed by the actuators. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the launch mode. Simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in presence of external disturbances and vehicle inertia uncertainties. This is a significant advancement in performance over that achieved with linear, gain scheduled control systems currently being used for launch vehicles.

  19. The association of ERCC1 and Pim -1 with chemotherapeutic effectiveness in NSCLC%ERCC1和 Pim -1表达与非小细胞肺癌化疗疗效的相关性

    Institute of Scientific and Technical Information of China (English)

    梁绪中; 刘合代; 倪裕丰; 丁昭珩; 姜峰; 李文霞; 丁罡

    2015-01-01

    目的:探讨非小细胞肺癌(non -small cell lung cancer,NSCLC )患者肺癌组织标本中 ERCC1和Pim -1的表达与临床特征及化疗疗效的相关性。方法:对我院病理确诊的70例 NSCLC 患者肿瘤组织,通过实时定量荧光 PCR 法检测 ERCC1和 Pim -1基因 mRNA 表达水平,回顾性分析 ERCC1和Pim -1基因表达与临床病理关系、铂类化疗疗效和总生存情况。结果:70例 NSCLC 患者肿瘤组织中 ERCC1和 Pim -1高表达患者比率分别为37.14%(26/70)和61.43%(43/70),ERCC1高表达与性别、吸烟史、组织类型、TNM 分期均无关(P >0.05),Pim -1高表达与性别、吸烟史相关(P <0.05),而与组织类型、TNM分期无关(P >0.05)。ERCC1和 Pim -1共同高表达率为20.00%(14/70)。ERCC1高表达组患者化疗有效率(19.23%,5/26)显著低于低表达组患者(47.73%,21/44)(P <0.05)。Pim -1高表达组患者化疗有效率(34.88%,15/43)和低表达组患者(40.74%,11/27)无统计学差异(P >0.05)。ERCC1和 Pim -1高表达组的中位生存期(median survival time,MST)为27个月和24个月低于低表达组的33个月和27个月,但无统计学差异(P >0.05)。结论:NSCLC 患者中 ERCC1低表达组患者化疗有效率和存活率高,是化疗受益的指标。%Objective:To investigate the relationship of the expression of ERCC1 and Pim -1 with the clinical fac-tors and chemotherapeutic efficacy in patients with NSCLC.Methods:Seventy cases with NSCLC pathologically proven were analyzed retrospectively.The mRNA expressions of ERCC1 and Pim -1 were detected by Real -time quantita-tive PCR(RT -QPCR).The clinical factors and platinum -based chemotherapeutic efficacy in lung canser patients were observed.Results:The expression rates of ERCC1 and Pim -1 in patients with NSCLC were 37.14%(26 /70) and 61.43%(43 /70).The

  20. Satellite time series analysis using Empirical Mode Decomposition

    Science.gov (United States)

    Pannimpullath, R. Renosh; Doolaeghe, Diane; Loisel, Hubert; Vantrepotte, Vincent; Schmitt, Francois G.

    2016-04-01

    Geophysical fields possess large fluctuations over many spatial and temporal scales. Satellite successive images provide interesting sampling of this spatio-temporal multiscale variability. Here we propose to consider such variability by performing satellite time series analysis, pixel by pixel, using Empirical Mode Decomposition (EMD). EMD is a time series analysis technique able to decompose an original time series into a sum of modes, each one having a different mean frequency. It can be used to smooth signals, to extract trends. It is built in a data-adaptative way, and is able to extract information from nonlinear signals. Here we use MERIS Suspended Particulate Matter (SPM) data, on a weekly basis, during 10 years. There are 458 successive time steps. We have selected 5 different regions of coastal waters for the present study. They are Vietnam coastal waters, Brahmaputra region, St. Lawrence, English Channel and McKenzie. These regions have high SPM concentrations due to large scale river run off. Trend and Hurst exponents are derived for each pixel in each region. The energy also extracted using Hilberts Spectral Analysis (HSA) along with EMD method. Normalised energy computed for each mode for each region with the total energy. The total energy computed using all the modes are extracted using EMD method.

  1. Pim-1: A Molecular Target to Modulate Cellular Resistance to Therapy in Prostate Cancer

    Science.gov (United States)

    2007-10-01

    oligonucleotide blocks pim1 increase after docetaxel treatment PIM1 pStat3 Total Stat3 Oligo M WT M WT Tax 0 + 0 + Fig...or with three other flavonoids , has been determined. We have also shown that quercetagetin is able to inhibit the activity of the PIM1 kinase in...companion article, presenting a pharmacophore analysis of flavonoid inhibitors of PIM1, has also been published recently (2; see appendix B). We have

  2. Discrete-Time Sliding Mode Control for Uncertain Networked System Subject to Time Delay

    Directory of Open Access Journals (Sweden)

    Saulo C. Garcia

    2015-01-01

    Full Text Available We deal with uncertain systems with networked sliding mode control, subject to time delay. To minimize the degenerative effects of the time delay, a simpler format of state predictor is proposed in the control law. Some ultimate bounded stability analyses and stabilization conditions are provided for the uncertain time delay system with proposed discrete-time sliding mode control strategy. A numerical example is presented to corroborate the analyses.

  3. Sub-20-Attosecond Timing Jitter Mode-Locked Fiber Lasers

    CERN Document Server

    Kim, Hyoji; Song, Youjian; Yang, Heewon; Shin, Junho; Kim, Chur; Jung, Kwangyun; Wang, Chingyue; Kim, Jungwon

    2014-01-01

    We demonstrate 14.3-attosecond timing jitter [integrated from 10 kHz to 94 MHz offset frequency] optical pulse trains from 188-MHz repetition-rate mode-locked Yb-fiber lasers. In order to minimize the timing jitter, we shorten the non-gain fiber length to shorten the pulsewidth and reduce excessive higher-order nonlinearity and nonlinear chirp in the fiber laser. The measured jitter spectrum is limited by the amplified spontaneous emission limited quantum noise in the 100 kHz - 1 MHz offset frequency range, while it was limited by the relative intensity noise-converted jitter in the lower offset frequency range. This intrinsically low timing jitter enables sub-100-attosecond synchronization between the two mode-locked Yb-fiber lasers over the full Nyquist frequency with a modest 10-kHz locking bandwidth. The demonstrated performance is the lowest timing jitter measured from any free-running mode-locked fiber lasers, comparable to the performance of the lowest-jitter Ti:sapphire solid-state lasers.

  4. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.

    Science.gov (United States)

    Xiang, Yibin; Hirth, Bradford; Asmussen, Gary; Biemann, Hans-Peter; Bishop, Kimberly A; Good, Andrew; Fitzgerald, Maria; Gladysheva, Tatiana; Jain, Annuradha; Jancsics, Katherine; Liu, Jinyu; Metz, Markus; Papoulis, Andrew; Skerlj, Renato; Stepp, J David; Wei, Ronnie R

    2011-05-15

    Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization. The compounds demonstrate potent inhibition against Pim-1 and Pim-2 in enzyme assays. Compound 29 has been tested in the Ambit 442 kinase panel and demonstrates good selectivity for the Pim kinase family. X-ray structures of the inhibitor/Pim-1 binding complex reveal important salt-bridge and hydrogen bond interactions mediated by the compound's carboxylic acid and amino groups.

  5. Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Kevin C., E-mail: kqian@rdg.boehringer-ingelheim.com [Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Research and Development, 175 Briar Ridge Road, Ridgefield, CT 06877 (United States); Studts, Joey; Wang, Lian; Barringer, Kevin; Kronkaitis, Anthony; Peng, Charline; Baptiste, Alistair; LaFrance, Roger; Mische, Sheenah [Department of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Research and Development, 175 Briar Ridge Road, Ridgefield, CT 06877 (United States); Farmer, Bennett [Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Research and Development, 175 Briar Ridge Road, Ridgefield, CT 06877 (United States)

    2005-01-01

    Pim kinases, belong to a distinctive serine/threonine protein-kinase family and are involved in cytokine-induced signal transduction and the development of lymphoid malignancies. Human Pim-1 kinase has been cloned, expressed and crystallized Pim kinases, including Pim-1, Pim-2 and Pim-3, belong to a distinctive serine/threonine protein-kinase family. They are involved in cytokine-induced signal transduction and the development of lymphoid malignancies. Their kinase domains are highly homologous to one another, but share low sequence identity to other kinases. Specifically, there are two proline residues in the conserved hinge-region sequence ERPXPX separated by a residue that is non-conserved among Pim kinases. Full-length human Pim-1 kinase (1–313) was cloned and expressed in Escherichia coli as a GST-fusion protein and truncated to Pim-1 (14–313) by thrombin digestion during purification. The Pim-1 (14–313) protein was purified to high homogeneity and monodispersity. This protein preparation yielded small crystals in the initial screening and large crystals after optimization. The large crystals of apo Pim-1 enzyme diffracted to 2.1 Å resolution and belong to space group P6{sub 5}, with unit-cell parameters a = b = 95.9, c = 80.0 Å, β = 120° and one molecule per asymmetric unit.

  6. Empirical mode decomposition using variable filtering with time scale calibrating

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A novel and efficient method for decomposing a signal into a set of intrinsic mode functions (IMFs) and a trend is proposed. Unlike the original empirical mode decomposition (EMD), which uses spline fits to extract variations from the signal by separating the local mean from the fluctuations in the decomposing process, this new method being proposed takes advantage of the theory of variable finite impulse response (FIR) filtering where filter coefficients and breakpoint frequencies can be adjusted to track any peak-to-peak time scale changes. The IMFs are results of a multiple variable frequency response FIR filtering when signals pass through the filters. Numerical examples validate that in contrast with the original EMD, the proposed method can fine-tune the frequency resolution and suppress the aliasing effectively.

  7. Adapting transport modes to supply chains classified by the uncertainty supply chain model: A case study at Manaus Industrial Pole

    Directory of Open Access Journals (Sweden)

    Fabiana Lucena Oliveira

    2017-01-01

    Full Text Available This paper discusses transport modes supporting Uncertainty Supply Chain Model (USCM in the case of Manaus Industrial Pole (PIM, an industrial cluster in the Brazilian Amazon that hosts six hundred factories with diverse logistics and supply chain managerial strategies. USCM (Lee, 2002; Fisher, 1997develops a dot matrix classification of the supply chains considering several attributes (e.g., agility, cost, security, responsiveness and argues that emergent economies industrial clusters, in the effort to keep attractiveness for technological frontier firms, need to adapt supply chain strategies according to USCM attributes. The paper takes a further step, discussing which transport modes are suitable to each supply chain classified at the USCM in PIM´s case. The research´s methods covered the use of PIM´s statistical official database (secondary data, interviews with the main logistical services providers of PIM and phone survey with a sample of firms (primary data. Findings confirm the theoretical argument that different supply chains will demand different transport modes running at the same time in the same industrial cluster (Oliveira, 2009. In the case of PIM, this implies investments on port and airport infrastructure and a strategic focus on air transport mode, due to (1 short life cycle of products, (2 distance from suppliers, (3 quick response to demand and (4 the fact that even PIM´s standard products use, in average, forty per cent of air transport at inbound logistics.

  8. Efficient auxiliary-mode approach for time-dependent nanoelectronics

    Science.gov (United States)

    Popescu, Bogdan Stefan; Croy, Alexander

    2016-09-01

    A new scheme for numerically solving the equations arising in the time-dependent non-equilibrium Green's function formalism is developed. It is based on an auxiliary-mode expansion of the self-energies which convert the complicated set of integro-differential equations into a set of ordinary differential equations. In the new scheme all auxiliary matrices are replaced by vectors or scalars. This drastically reduces the computational effort and memory requirements of the method, rendering it applicable to topical problems in electron quantum optics and molecular electronics. As an illustrative example we consider the dynamics of a Leviton wave-packet in a 1D wire.

  9. Experimental Analysis of the Fault Tolerance of the PIM-SM IP Multicast Routing Protocol under GNS3

    Directory of Open Access Journals (Sweden)

    Gábor Lencse

    2014-06-01

    Full Text Available PIM-SM is the most commonly used IP multicast routing protocol in IPTV systems. Its fault tolerance is examined by experimenting on a mesh topology multicast test network built up by Cisco routers under GNS3. Different fault scenarios are played and different parameters of the PIM-SM and of the OSPF protocols are examined if they influence and how they influence the outage time of an IPTV service. The failure of the Rendezvous Point (RP of the given IP multicast group as well as the complete failure of a router in the media forwarding path of the multicast stream are examined. A method is given how the service outage time caused by the complete failure of a router can be limited by an appropriate choice of the Dead Interval parameter of OSPF.

  10. PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

    Directory of Open Access Journals (Sweden)

    Esperanza Martín-Sánchez

    Full Text Available Currently, there is no efficient therapy for patients with peripheral T cell lymphoma (PTCL. The Proviral Integration site of Moloney murine leukemia virus (PIM kinases are important mediators of cell survival. We aimed to determine the therapeutic value of PIM kinases because they are overexpressed in PTCL patients, T cell lines and primary tumoral T cells. PIM kinases were inhibited genetically (using small interfering and short hairpin RNAs and pharmacologically (mainly with the pan-PIM inhibitor (PIMi ETP-39010 in a panel of 8 PTCL cell lines. Effects on cell viability, apoptosis, cell cycle, key proteins and gene expression were evaluated. Individual inhibition of each of the PIM genes did not affect PTCL cell survival, partially because of a compensatory mechanism among the three PIM genes. In contrast, pharmacological inhibition of all PIM kinases strongly induced apoptosis in all PTCL cell lines, without cell cycle arrest, in part through the induction of DNA damage. Therefore, pan-PIMi synergized with Cisplatin. Importantly, pharmacological inhibition of PIM reduced primary tumoral T cell viability without affecting normal T cells ex vivo. Since anaplastic large cell lymphoma (ALK+ ALCL cell lines were the most sensitive to the pan-PIMi, we tested the simultaneous inhibition of ALK and PIM kinases and found a strong synergistic effect in ALK+ ALCL cell lines. Our findings suggest that PIM kinase inhibition could be of therapeutic value in a subset of PTCL, especially when combined with ALK inhibitors, and might be clinically beneficial in ALK+ ALCL.

  11. Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

    Directory of Open Access Journals (Sweden)

    Ulrike Weirauch

    2013-07-01

    Full Text Available PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1 kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim-1 in colon carcinoma. EXPERIMENTAL DESIGN: RNAi-based knockdown approaches, as well as a specific small molecule inhibitor, were used to inhibit Pim-1 in colon carcinoma cells. The effects were analyzed regarding proliferation, apoptosis, sensitization toward cytostatic treatment, and overall antitumor effect in vitro and in mouse tumor models in vivo. RESULTS: We demonstrate antiproliferative, proapoptotic, and overall antitumor effects of Pim-1 inhibition. The sensitization to 5-fluorouracil (5-FU treatment upon Pim-1 knockdown offers new possibilities for combinatorial treatment approaches. Importantly, this also antagonizes a 5-FU-triggered Pim-1 up-regulation, which is mediated by decreased levels of miR-15b, a microRNA we newly identify to regulate Pim-1. The analysis of the molecular effects of Pim-1 inhibition reveals a complex regulatory network, with therapeutic Pim-1 repression leading to major changes in oncogenic signal transduction with regard to p21Cip1/WAF1, STAT3, c-jun-N-terminal kinase (JNK, c-Myc, and survivin and in the levels of apoptosis-related proteins Puma, Bax, and Bcl-xL. CONCLUSIONS: We demonstrate that Pim-1 plays a pivotal role in several tumor-relevant signaling pathways and establish the functional relevance of Pim-1 in colon carcinoma. Our results also substantiate the RNAi-mediated Pim-1 knockdown based on polymeric polyethylenimine/ small interfering RNA nanoparticles as a promising therapeutic approach.

  12. Sliding mode control method having terminal convergence in finite time

    Science.gov (United States)

    Venkataraman, Subramanian T. (Inventor); Gulati, Sandeep (Inventor)

    1994-01-01

    An object of this invention is to provide robust nonlinear controllers for robotic operations in unstructured environments based upon a new class of closed loop sliding control methods, sometimes denoted terminal sliders, where the new class will enforce closed-loop control convergence to equilibrium in finite time. Improved performance results from the elimination of high frequency control switching previously employed for robustness to parametric uncertainties. Improved performance also results from the dependence of terminal slider stability upon the rate of change of uncertainties over the sliding surface rather than the magnitude of the uncertainty itself for robust control. Terminal sliding mode control also yields improved convergence where convergence time is finite and is to be controlled. A further object is to apply terminal sliders to robot manipulator control and benchmark performance with the traditional computed torque control method and provide for design of control parameters.

  13. Regulatory modes and time management: how locomotors and assessors plan and perceive time.

    Science.gov (United States)

    Amato, Clara; Pierro, Antonio; Chirumbolo, Antonio; Pica, Gennaro

    2014-06-01

    This research investigated the relationship between regulatory mode orientations (locomotion and assessment), time management behaviours and the perceived control of time. "Locomotion" refers to the aspect of self-regulation involving the movement from state to state, whereas "assessment" is the comparative aspect of self-regulation that refers to the critical evaluation of alternative goals and the means for achieving them. The Italian versions of the Time Management Behavior Scale and the Perceived Control of Time Scale, as well as the Locomotion and Assessment Regulatory Modes Scales were administered to 339 Italian participants (249 students and 90 employees). The results supported the notion that locomotors and assessors differ in the ways they perceive the control of time. Locomotion was found to be positively related to perceived control of time. In contrast, assessment was negatively related to perceived control of time. Furthermore, the two time management dimensions of setting goals and priorities and preference for organisation were shown to mediate the relationship between locomotion and perceived control of time, whereas assessment proved to be unrelated to all time management behaviours. These findings highlight the importance of regulatory modes for human behaviour regarding time management and perceived control of time.

  14. Nuclear PIM1 confers resistance to rapamycin-impaired endothelial proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Walpen, Thomas; Kalus, Ina [Research Unit, Division Internal Medicine, University Hospital Zuerich, 8091 Zuerich (Switzerland); Schwaller, Juerg [Department of Biomedicine, University of Basel, 4031 Basel (Switzerland); Peier, Martin A. [Research Unit, Division Internal Medicine, University Hospital Zuerich, 8091 Zuerich (Switzerland); Battegay, Edouard J. [Research Unit, Division Internal Medicine, University Hospital Zuerich, 8091 Zuerich (Switzerland); Zurich Center for Integrative Human Physiology (ZIHP), 8057 Zuerich (Switzerland); Humar, Rok, E-mail: Rok.Humar@usz.ch [Research Unit, Division Internal Medicine, University Hospital Zuerich, 8091 Zuerich (Switzerland); Zurich Center for Integrative Human Physiology (ZIHP), 8057 Zuerich (Switzerland)

    2012-12-07

    Highlights: Black-Right-Pointing-Pointer Pim1{sup -/-} endothelial cell proliferation displays increased sensitivity to rapamycin. Black-Right-Pointing-Pointer mTOR inhibition by rapamycin enhances PIM1 cytosolic and nuclear protein levels. Black-Right-Pointing-Pointer Truncation of Pim1 beyond serine 276 results in nuclear localization of the kinase. Black-Right-Pointing-Pointer Nuclear PIM1 increases endothelial proliferation independent of rapamycin. -- Abstract: The PIM serine/threonine kinases and the mTOR/AKT pathway integrate growth factor signaling and promote cell proliferation and survival. They both share phosphorylation targets and have overlapping functions, which can partially substitute for each other. In cancer cells PIM kinases have been reported to produce resistance to mTOR inhibition by rapamycin. Tumor growth depends highly on blood vessel infiltration into the malignant tissue and therefore on endothelial cell proliferation. We therefore investigated how the PIM1 kinase modulates growth inhibitory effects of rapamycin in mouse aortic endothelial cells (MAEC). We found that proliferation of MAEC lacking Pim1 was significantly more sensitive to rapamycin inhibition, compared to wildtype cells. Inhibition of mTOR and AKT in normal MAEC resulted in significantly elevated PIM1 protein levels in the cytosol and in the nucleus. We observed that truncation of the C-terminal part of Pim1 beyond Ser 276 resulted in almost exclusive nuclear localization of the protein. Re-expression of this Pim1 deletion mutant significantly increased the proliferation of Pim1{sup -/-} cells when compared to expression of the wildtype Pim1 cDNA. Finally, overexpression of the nuclear localization mutant and the wildtype Pim1 resulted in complete resistance to growth inhibition by rapamycin. Thus, mTOR inhibition-induced nuclear accumulation of PIM1 or expression of a nuclear C-terminal PIM1 truncation mutant is sufficient to increase endothelial cell proliferation

  15. Investigation of neutral and ion dynamics in a HiPIMS plasma by tunable laser diode absorption spectroscopy (TDLAS)

    Science.gov (United States)

    Preissing, Patrick; Hecimovic, Ante; von Keudell, Achim

    2016-09-01

    High power impulse magnetron sputtering (HiPIMS) discharges are known for complex plasma interactions, and complex temporal and spatial dynamics. Spatial and temporal dynamic of argon metastable (Arm), Ti atom (Ti0) and Ti ion (Ti+) density and temperature is studied by an extended tunable diode laser absorption spectroscopy setup (TDLAS) during a HiPIMS pulse. The TDLAS setup used a beam expander in combination with a 6 photo diode array to simultaneously measure spatial (resolution 5 mm) and time resolved absorption profiles of an Arm, Ti0 and Ti+ transition. This in combination with moving the magnetron in axial direction gives a complete 2D map of the density evolution. Temporal resolution of 400 ns was achieved by recording the photo diode signal on the National Instruments card. Final results allowed to investigate temporal evolution of the observed species in the volume between the target and the substrate.

  16. Finite-Time Reentry Attitude Control Using Time-Varying Sliding Mode and Disturbance Observer

    Directory of Open Access Journals (Sweden)

    Xuzhong Wu

    2015-01-01

    Full Text Available This paper presents the finite-time attitude control problem for reentry vehicle with redundant actuators in consideration of planet uncertainties and external disturbances. Firstly, feedback linearization technique is used to cancel the nonlinearities of equations of motion to construct a basic mode for attitude controller. Secondly, two kinds of time-varying sliding mode control methods with disturbance observer are integrated with the basic mode in order to enhance the control performance and system robustness. One method is designed based on boundary layer technique and the other is a novel second-order sliding model control method. The finite-time stability analyses of both resultant closed-loop systems are carried out. Furthermore, after attitude controller produces the torque commands, an optimization control allocation approach is introduced to allocate them into aerodynamic surface deflections and on-off reaction control system thrusts. Finally, the numerical simulation results demonstrate that both of the time-varying sliding mode control methods are robust to uncertainties and disturbances without chattering phenomenon. Moreover, the proposed second-order sliding mode control method possesses better control accuracy.

  17. Pure- and mixed-gas CO2/CH4 separation properties of PIM-1 and an amidoxime-functionalized PIM-1

    KAUST Repository

    Swaidan, Raja

    2014-05-01

    The prototypical solution-processable polymer of intrinsic microporosity, PIM-1, and derivatives thereof offer combinations of permeability and selectivity that make them potential candidate materials for membrane-based gas separations. Paramount to the design and evaluation of PIMs for economical natural gas sweetening is a high and stable CO2/CH4 selectivity under realistic, mixed-gas conditions. Here, amidoxime-functionalized PIM-1 (AO-PIM-1) was prepared and examined for fundamental structure/property relationships. Qualitative NLDFT pore-size distribution analyses of physisorption isotherms (N2 at -196 oC; CO2 at 0 oC) reveal a tightened microstructure indicating size-sieving ultra-microporosity (<7Å). AO-PIM-1 demonstrated a three-fold increase in αD(CO2/CH4) over PIM-1, surpassing the 2008 upper bound with P(CO2)=1153Barrer and ideal α(CO2/CH4)=34. Under a 50:50 CO2:CH4 mixed-gas feed, AO-PIM-1 showed less selectivity loss than PIM-1, maintaining a mixed-gas α(CO2/CH4) ~21 across a 20bar pressure range. Conversely, PIM-1 endured up to 60% increases in mixed-gas CH4 permeability over pure-gas values concurrent with a selectivity of only ~8 at 20bar. A pervasive intermolecular hydrogen bonding network in AO-PIM-1 predominantly yields a rigidified microstructure that mitigates CO2-induced matrix dilations, reducing detrimental mixed-gas CH4 copermeation. © 2014 Elsevier B.V.

  18. Observer-based robust finite time H∞ sliding mode control for Markovian switching systems with mode-dependent time-varying delay and incomplete transition rate.

    Science.gov (United States)

    Gao, Lijun; Jiang, Xiaoxiao; Wang, Dandan

    2016-03-01

    This paper investigates the problem of robust finite time H∞ sliding mode control for a class of Markovian switching systems. The system is subjected to the mode-dependent time-varying delay, partly unknown transition rate and unmeasurable state. The main difficulty is that, a sliding mode surface cannot be designed based on the unknown transition rate and unmeasurable state directly. To overcome this obstacle, the set of modes is firstly divided into two subsets standing for known transition rate subset and unknown one, based on which a state observer is established. A component robust finite-time sliding mode controller is also designed to cope with the effect of partially unknown transition rate. It is illustrated that the reachability, finite-time stability, finite-time boundedness, finite-time H∞ state feedback stabilization of sliding mode dynamics can be ensured despite the unknown transition rate. Finally, the simulation results verify the effectiveness of robust finite time control problem.

  19. Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.

    Science.gov (United States)

    Good, Andrew C; Liu, Jinyu; Hirth, Bradford; Asmussen, Gary; Xiang, Yibin; Biemann, Hans-Peter; Bishop, Kimberly A; Fremgen, Trisha; Fitzgerald, Maria; Gladysheva, Tatiana; Jain, Annuradha; Jancsics, Katherine; Metz, Markus; Papoulis, Andrew; Skerlj, Renato; Stepp, J David; Wei, Ronnie R

    2012-03-22

    We have studied the subtleties of fragment docking and binding using data generated in a Pim-1 kinase inhibitor program. Crystallographic and docking data analyses have been undertaken using inhibitor complexes derived from an in-house surface plasmon resonance (SPR) fragment screen, a virtual needle screen, and a de novo designed fragment inhibitor hybrid. These investigations highlight that fragments that do not fill their binding pocket can exhibit promiscuous hydrophobic interactions due to the lack of steric constraints imposed on them by the boundaries of said pocket. As a result, docking modes that disagree with an observed crystal structure but maintain key crystallographically observed hydrogen bonds still have potential value in ligand design and optimization. This observation runs counter to the lore in fragment-based drug design that all fragment elaboration must be based on the parent crystal structure alone.

  20. Real-Time Transportation Mode Identification Using Artificial Neural Networks Enhanced with Mode Availability Layers: A Case Study in Dubai

    Directory of Open Access Journals (Sweden)

    Young-Ji Byon

    2017-09-01

    Full Text Available Traditionally, departments of transportation (DOTs have dispatched probe vehicles with dedicated vehicles and drivers for monitoring traffic conditions. Emerging assisted GPS (AGPS and accelerometer-equipped smartphones offer new sources of raw data that arise from voluntarily-traveling smartphone users provided that their modes of transportation can correctly be identified. By introducing additional raster map layers that indicate the availability of each mode, it is possible to enhance the accuracy of mode detection results. Even in its simplest form, an artificial neural network (ANN excels at pattern recognition with a relatively short processing timeframe once it is properly trained, which is suitable for real-time mode identification purposes. Dubai is one of the major cities in the Middle East and offers unique environments, such as a high density of extremely high-rise buildings that may introduce multi-path errors with GPS signals. This paper develops real-time mode identification ANNs enhanced with proposed mode availability geographic information system (GIS layers, firstly for a universal mode detection and, secondly for an auto mode detection for the particular intelligent transportation system (ITS application of traffic monitoring, and compares the results with existing approaches. It is found that ANN-based real-time mode identification, enhanced by mode availability GIS layers, significantly outperforms the existing methods.

  1. A review of time-domain and frequency-domain component mode synthesis method

    Science.gov (United States)

    Craig, R. R., Jr.

    1985-01-01

    Hurty (1965) has conducted a dynamic analysis of structural systems using component modes. The component mode synthesis (CMS) procedure considered by him represents a form of substructure coupling analysis which is often utilized in structural dynamics. Time-domain CMS methods employing real modes are discussed, taking into account real component modes, normal modes, redundant constraint modes, rigid-body modes, attachment modes, inertia-relief modes, statically-complete interface mode sets, dynamic component mode supersets, component modal models, the coupling of components, and the classification of methods. Attention is also given to the experimental determination of component mode synthesis parameters, time-domain CMS methods for damped systems, and frequency-domain CMS methods for damped systems.

  2. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

    Directory of Open Access Journals (Sweden)

    Alex N Bullock

    Full Text Available BACKGROUND: The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of anticancer agents. To date our knowledge of catalytic domain structures of the PIM kinase family is limited to PIM1 which has been extensively studied and which shares about 50% sequence identity with PIM2. PRINCIPAL FINDINGS: Here we determined the crystal structure of PIM2 in complex with an organoruthenium complex (inhibition in sub-nanomolar level. Due to its extraordinary shape complementarity this stable organometallic compound is a highly potent inhibitor of PIM kinases. SIGNIFICANCE: The structure of PIM2 revealed several differences to PIM1 which may be explored further to generate isoform selective inhibitors. It has also demonstrated how an organometallic inhibitor can be adapted to the binding site of protein kinases to generate highly potent inhibitors. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1.

  3. Analysis of the Mode of the Periodically Time-varying Vibration Systems

    Institute of Scientific and Technical Information of China (English)

    WANG Sheng-ze; REN Ji-ge

    2007-01-01

    By Liapunov reducibility theorem, the periodically time-varying vibration system can be transformed to a linear time-invariant system. Based on the dynamic characteristics of the linear time-invariant system, the mode of the periodically time-varying vibration system has been discussed. The paper defines the mode and analyzes its characteristics. It can be found that the mode of the periodically time-varying system is periodically time-varing but has such characteristics as orthogonality. Finally, a method is given to solve the mode. By solving the eigenvalues and the eigenvectors of the state transition matrix in one period, the periodically time-varying mode can be obtained.

  4. Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.

    Science.gov (United States)

    Ha, S; Iqbal, N J; Mita, P; Ruoff, R; Gerald, W L; Lepor, H; Taneja, S S; Lee, P; Melamed, J; Garabedian, M J; Logan, S K

    2013-08-22

    Integration of cellular signaling pathways with androgen receptor (AR) signaling can be achieved through phosphorylation of AR by cellular kinases. However, the kinases responsible for phosphorylating the AR at numerous sites and the functional consequences of AR phosphorylation are only partially understood. Bioinformatic analysis revealed AR serine 213 (S213) as a putative substrate for PIM1, a kinase overexpressed in prostate cancer. Therefore, phosphorylation of AR serine 213 by PIM1 was examined using a phosphorylation site-specific antibody. Wild-type PIM1, but not catalytically inactive PIM1, specifically phosphorylated AR but not an AR serine-to-alanine mutant (S213A). In vitro kinase assays confirmed that PIM1 can phosphorylate AR S213 in a ligand-independent manner and cell type-specific phosphorylation was observed in prostate cancer cell lines. Upon PIM1 overexpression, AR phosphorylation was observed in the absence of hormone and was further increased in the presence of hormone in LNCaP, LNCaP-abl and VCaP cells. Moreover, phosphorylation of AR was reduced in the presence of PIM kinase inhibitors. An examination of AR-mediated transcription showed that reporter gene activity was reduced in the presence of PIM1 and wild-type AR, but not S213A mutant AR. Androgen-mediated transcription of endogenous PSA, Nkx3.1 and IGFBP5 was also decreased in the presence of PIM1, whereas IL6, cyclin A1 and caveolin 2 were increased. Immunohistochemical analysis of prostate cancer tissue microarrays showed significant P-AR S213 expression that was associated with hormone refractory prostate cancers, likely identifying cells with catalytically active PIM1. In addition, prostate cancers expressing a high level of P-AR S213 were twice as likely to be from biochemically recurrent cancers. Thus, AR phosphorylation by PIM1 at S213 impacts gene transcription and is highly prevalent in aggressive prostate cancer.

  5. Anomalous cross-B field transport and spokes in HiPIMS plasma

    Science.gov (United States)

    Hecimovic, A.

    2016-05-01

    Localized light emission patterns observed during on time of a high power impulse magnetron sputtering (HiPIMS) discharge on a planar magnetron, known as spokes or ionization zones, have been identified as a potential source of anomalous cross-B field diffusion. In this paper experimental evidence is presented that anomalous diffusion is triggered by the appearance of spokes. The Hall parameter {ω\\text{ce}}{τ\\text{c}} , product of the electron cyclotron frequency and the classical collision time, reduces from Bohm diffusion values (∼ 16 and higher) down to the value of 3 as spokes appear, indicating anomalous cross-B field transport. A combination of intensified charge coupled device imaging and electric probe measurements reveals that the ions from the spokes are instantaneously diffusing away from the target. The ion diffusion coefficients calculated from a sideways image of the spoke are six times higher than Bohm diffusion coefficients, which is consistent with the reduction of the Hall parameter.

  6. Tuning PIM-PI-Based Membranes for Highly Selective Transport of Propylene/Propane

    KAUST Repository

    Swaidan, Ramy J.

    2016-12-06

    . For the first time attempted for C3H6/C3H8 separation, high temperature heating of a PIM-PI to form thermally-rearranged and carbon molecular sieve membranes was employed. The TR membrane showed increased C3H6 permeability and about 50% losses in C3H6/C3H8 selectivity, while the CMS membrane formed at 600 oC showed modest gains in C3H6/C3H8 selectivity with significant improvements in C3H6 permeability. Finally, hybrid nanocomposite membranes incorporating a metal-organic framework structure into a PIM-PI matrix was used. ZIF-8, which has demonstrated high diffusive selectivities for C3H6/C3H8, was dispersed within the polymer, since previous work by the Koros group indicated that its incorporation into polyimide matrices can facilitate major improvements in both C3H6/C3H8 selectivity and C3H6 permeability compared to the respective neat polymer. Focus was directed towards attempting to improve polymer/nanoparticle adhesion by enhancing the interactions between the polymer and filler particles to mitigate the interfacial defects notorious in mixed-matrix membranes (MMM). To do so, ZIF-8 was dispersed into one of the best performing hydroxyl functionalized PIM-PI for the C3H6/C3H8 separation. The highest loaded mixed-matrix membrane in a glassy polymer to date of 65% (w/w) was achieved. The membranes showed pure-gas selectivities ranging from 34 with 10 Barrer at 30% loading to 43 with 38 Barrer at 65% loading. Strong performance and plasticization resistance were sustained in mixed-gas experiments even to feed pressures approaching the vapor pressure of the C3H6/C3H8 mixture, as selectivities well over 20 were achieved with high permeabilities, thereby demonstrating the potential commercial viability. Based on the work reported in this dissertation, we hope to help lay a framework to be able to tailor membrane performance and future membrane design to meet the demands of the different applications of the propylene/propane separation and hence show that there can be a

  7. Storing Personal Information Management data: Akonadi - unifying PIM data for KDE

    NARCIS (Netherlands)

    Zwerus, R.

    2007-01-01

    Storing Personal Information Management (PIM) data is not trivial, because of the variety in content types. Existing PIM storage systems have shortcomings in performance, data concistency and/or concurrency. In this thesis, we propose several optimisations and test them in Akonadi, KDE’s new central

  8. For better or for worse : the role of Pim oncogenes in tumorigenesis

    NARCIS (Netherlands)

    Nawijn, Martijn C.; Alendar, Andrej; Berns, Anton

    2011-01-01

    Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerab

  9. Exploring New Potentials of Blogs for Learning: Can Children Use Blogs for Personal Information Management (PIM)?

    Science.gov (United States)

    Yeo, Hwan-Ik; Lee, Yekyung Lisa

    2014-01-01

    This study explores the use of blogs for personal information management (PIM) as a learning tool that could bring increased efficiency and academic self-efficacy for carrying out learning tasks. In order to identify the uses and effects of using blogs for PIM by children, a control group that used personal spaces within the class website and an…

  10. Inhibition of Pim-1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells

    Institute of Scientific and Technical Information of China (English)

    Wei Jie; Qi-Yi He; Bo-Tao Luo; Shao-Jiang Zheng; Yue-Qiong Kong; Han-Guo Jiang; Ru-Jia Li; Jun-Li Guo; Zhi-Hua Shen

    2012-01-01

    Objective:To explore the role of proto-oncogenePim-1 in the proliferation and migration of nasopharyngeal carcinoma(NPC) cells.Methods:Pim-1 expressions inNPC cell lines CNE1,CNE1-GL,CNE-2Z andC666-1 were examined byRT-PCR, western blotting and immunoflucesence, respectively.AfterCNE1,CNE1-GL andC666-1 cells were treated with different concentrations ofPim-1 special inhibitor, quercetagetin, the cell viability, colony formation rate and migration ability were analyzed.Results:Pim-1 expression was negative in well-differentiatedCNE1 cells, whereas expressed weakly positive in poor-differentiated CNE-2Z cells and strongly positive in undifferentiatedC666-1 cells.Interestingly,CNE1-GL cells that derived fromCNE1 transfected with anEpsteinBarr virus latent membrane protein-1 over-expression plasmid displayed stronger expression ofPim-1.Treatment ofCNE1-GL and C666-1 cells with quercetagetin significantly decreased the cell viability, colony formation rate and migration ability but not theCNE1 cells.Conclusions:These findings suggest thatPim-1 overexpression contributes toNPC proliferation and migration, and targetingPim-1 may be a potential treatment for anti-Pim-1-expressedNPCs.

  11. DMPD: The serine/threonine kinase Pim-1. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15694833 The serine/threonine kinase Pim-1. Bachmann M, Moroy T. Int J Biochem Cell... Biol. 2005 Apr;37(4):726-30. (.png) (.svg) (.html) (.csml) Show The serine/threonine kinase Pim-1. PubmedID 15694833 Title The

  12. Holding Pressure and Its Influence on Quality in PIM Technology

    Directory of Open Access Journals (Sweden)

    Pavel Petera

    2012-01-01

    Full Text Available The PIM (powder injection molding process consists of several steps in which faults can occur. The quality of the part that is produced usually cannot be seen until the end of the process. It is therefore necessary to find a way to discover the fault earlier in the process. The cause of defects is very often “phase separation” (inhomogeneity in powder distribution, which can also be influenced by the holding pressure. This paper evaluates the powder distribution with a new method based on density measurement. Measurements were made using various holding pressure values.

  13. Time dependent intrinsic correlation analysis of temperature and dissolved oxygen time series using empirical mode decomposition

    CERN Document Server

    Huang, Y X

    2014-01-01

    In the marine environment, many fields have fluctuations over a large range of different spatial and temporal scales. These quantities can be nonlinear \\red{and} non-stationary, and often interact with each other. A good method to study the multiple scale dynamics of such time series, and their correlations, is needed. In this paper an application of an empirical mode decomposition based time dependent intrinsic correlation, \\red{of} two coastal oceanic time series, temperature and dissolved oxygen (saturation percentage) is presented. The two time series are recorded every 20 minutes \\red{for} 7 years, from 2004 to 2011. The application of the Empirical Mode Decomposition on such time series is illustrated, and the power spectra of the time series are estimated using the Hilbert transform (Hilbert spectral analysis). Power-law regimes are found with slopes of 1.33 for dissolved oxygen and 1.68 for temperature at high frequencies (between 1.2 and 12 hours) \\red{with} both close to 1.9 for lower frequencies (t...

  14. Mode coupling mechanism for late-time Kerr tails

    CERN Document Server

    Burko, Lior M

    2013-01-01

    We consider the decay rate for scalar fields in Kerr spacetime. We consider pure initial (azimuthal) multipoles $\\ell'$ with respect to the class which includes Boyer-Lindquist coordinates, and focus attention on the decay rate of the multipole $\\ell$. We use an iterative method proposed by Gleiser, Price, and Pullin, and identify the mode coupling mechanism through the iterations in powers of the square of the Kerr black hole's specific angular momentum that gives rise to a decay rate formula recently proposed by Zengino\\u{g}lu, Khanna, and Burko. Modes $\\ell$ may be excited through different channels, each leading to its own decay rate. The asymptotic decay rate of the mode $\\ell$ is the slowest of the decay rate of the various channels. In some cases, more than one channel leads to the same decay rate, and then the amplitude of the mode is the sum of the amplitudes of the partial fields generated by the individual channels. We also show that one may identify the asymptotically-dominant channel of mode exci...

  15. On the internal resonant modes in marching-on-in-time solution of the time domain electric field integral equation

    KAUST Repository

    Shi, Yifei

    2013-08-01

    Internal resonant modes are always observed in the marching-on-in-time (MOT) solution of the time domain electric field integral equation (EFIE), although \\'relaxed initial conditions,\\' which are enforced at the beginning of time marching, should in theory prevent these spurious modes from appearing. It has been conjectured that, numerical errors built up during time marching establish the necessary initial conditions and induce the internal resonant modes. However, this conjecture has never been proved by systematic numerical experiments. Our numerical results in this communication demonstrate that, the internal resonant modes\\' amplitudes are indeed dictated by the numerical errors. Additionally, it is shown that in a few cases, the internal resonant modes can be made \\'invisible\\' by significantly suppressing the numerical errors. These tests prove the conjecture that the internal resonant modes are induced by numerical errors when the time domain EFIE is solved by the MOT method. © 2013 IEEE.

  16. Effect of thermo-mechanical properties of PIM feedstock on compacts shape retention during debinding process

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The removal of the binder from the powder compacts (debinding) can be a slow step and a source of problems. To improve the debinding process of powder injection molding operation, it's necessary to understand the thermal and mechanical properties of powder injection molding feedstocks and to find the major causes responsible for molding difficulties and compacts shape retention during debinding process. The effects of thermo-mechanical properties of the PIM feedstock on the compacts shape retention during debinding process were discussed and explained from practical point of view. The results indicate that the heat of fusion affects the cooling time. The binder component with high heat of fusion and high-decomposed temperature is more effective as the second binder component for the compact to retain its shape during debinding.

  17. Comparison of measurements from optical CMM and focus-variation microscope of a μPIM mechanical part

    DEFF Research Database (Denmark)

    Quagliotti, Danilo; Salaga, Jacek; Tosello, Guido

    2016-01-01

    Two sets of 5 green and 5 sintered mechanical parts, manufactured by micro powder injection moulding (μPIM), were measured using an optical coordinate measuring machine (OCMM) and a focus-variation microscope (FVM). The examined features of size, including diameter, radii and distances, span...... geometrical features, such as surface texture and flatness, may depict FVM measurements as more attractive. However, measurements should be suitable for in-line quality control, in a production environment, where fast cycle time is required and measuring times are more compatible to those of the OCMM....

  18. Experimental demonstration of time- and mode-division multiplexed passive optical network

    Science.gov (United States)

    Ren, Fang; Li, Juhao; Tang, Ruizhi; Hu, Tao; Yu, Jinyi; Mo, Qi; He, Yongqi; Chen, Zhangyuan; Li, Zhengbin

    2017-07-01

    A time- and mode-division multiplexed passive optical network (TMDM-PON) architecture is proposed, in which each optical network unit (ONU) communicates with the optical line terminal (OLT) independently utilizing both different time slots and switched optical linearly polarized (LP) spatial modes. Combination of a mode multiplexer/demultiplexer (MUX/DEUX) and a simple N × 1 optical switch is employed to select the specific LP mode in each ONU. A mode-insensitive power splitter is used for signal broadcast/combination between OLT and ONUs. We theoretically propose a dynamic mode and time slot assignment scheme for TMDM-PON based on inter-ONU priority rating, in which the time delay and packet loss ratio's variation tendency are investigated by simulation. Moreover, we experimentally demonstrate 2-mode TMDM-PON transmission over 10 km FMF with 10-Gb/s on-off keying (OOK) signal and direct detection.

  19. Cuestiones pendientes en la metodología PIMS: un breve recuento Pending question about the PIMS methodology: a brief account

    Directory of Open Access Journals (Sweden)

    Rubén M. Mosqueda Almanza

    2010-06-01

    Full Text Available Se asume que una estrategia adecuada impactara positivamente las ganancias de la empresa y le llevara a expandirse. Recientes descubrimientos sugieren que solo con la revisión y adecuación de los elementos mas relevantes del plan estratégico es posible llevar los resultados económicos de la empresa a un punto optimo. La metodología PIMS (que se traduce como Impacto de la Estrategia de Marketing sobre las Ganancias constituye un modelo para lograrlo, sin embargo, subsisten problemas fundamentales en el mismo modelo que lo limitan. Así, en el presente trabajo se hace un estudio exploratorio y se muestra la evolución de la metodología PIMS lo cual permite desvelar los retos y el posible rumbo del tema. La definición de la estrategia, el diseño de la encuesta tipo PIMS, los problemas de multicolinearidad y el efecto de la participación de mercado se plantean como los mas relevantes. Los resultados muestran la necesidad de definir con precisión la estrategia asumida por la empresa, el rediseño de la encuesta PIMS cuando se aplique a mercados incompletos y finalmente, se advierte un avance en el estudio econométrico sobre la metodología PIMS con énfasis en la variable Calidad Relativa del Producto para resolver el viejo dilema del efecto de la participación de mercado.We can assume that an appropriate strategy will have a positive impact on profits and it will contribute to having a company’s market share grow. Recent findings suggest that only the adaptation of a strategic plan can bring a company to perform at optimum levels. PIMS is an archetypical model to achieve that, but fundamental problems remain that limit it. This paper shows the evolution of the PIMS methodology and reveals its challenges and possible development. The adequate definition of this strategy, the redesign of the questionnaire PIMS, problems of Multicollinearity and the Market Share Effect would be the most relevant problems that this paper will address. The

  20. Analytical impact time and angle guidance via time-varying sliding mode technique.

    Science.gov (United States)

    Zhao, Yao; Sheng, Yongzhi; Liu, Xiangdong

    2016-05-01

    To concretely provide a feasible solution for homing missiles with the precise impact time and angle, this paper develops a novel guidance law, based on the nonlinear engagement dynamics. The guidance law is firstly designed with the prior assumption of a stationary target, followed by the practical extension to a moving target scenario. The time-varying sliding mode (TVSM) technique is applied to fulfill the terminal constraints, in which a specific TVSM surface is constructed with two unknown coefficients. One is tuned to meet the impact time requirement and the other one is targeted with a global sliding mode, so that the impact angle constraint as well as the zero miss distance can be satisfied. Because the proposed law possesses three guidance gain as design parameters, the intercept trajectory can be shaped according to the operational conditions and missile׳s capability. To improve the tolerance of initial heading errors and broaden the application, a new frame of reference is also introduced. Furthermore, the analytical solutions of the flight trajectory, heading angle and acceleration command can be totally expressed for the prediction and offline parameter selection by solving a first-order linear differential equation. Numerical simulation results for various scenarios validate the effectiveness of the proposed guidance law and demonstrate the accuracy of the analytic solutions.

  1. PIM-SM Based Multicast Security%基于PIM-SM协议IP组播安全技术

    Institute of Scientific and Technical Information of China (English)

    黄舒; 董喜明; 郭云峰

    2014-01-01

    With the rapid development of the network technology, more bandwidth is required. Multicast transmission offers efficient network resource consumption. Multicast security is a hot issue. Multicast security problem hinders the development of multicast technology. This paper discusses the principles of multicast protocol PIM-SM and makes a detailed description of a method to prevent vicious multicast source attacking. The method can improve the reliability of multicast system.%伴随着互联网的高速发展, Internet 上涌现了许多需要高带宽支持的应用。组播技术能有效的利用网络带宽资源。组播的安全性一直是一个热点问题,也是阻碍组播发展的一个主要问题。本文针对虚假组播源产生垃圾消息恶性攻击提出了一个基于 PIM-SM 组播协议的预防方案,实验结果表明,该方案能提高组播系统的可靠性。

  2. Human CD180 Transmits Signals via the PIM-1L Kinase.

    Directory of Open Access Journals (Sweden)

    Nicole Egli

    Full Text Available Toll-like receptors (TLRs are important sensors of the innate immune system that recognize conserved structural motifs and activate cells via a downstream signaling cascade. The CD180/MD1 molecular complex is an unusual member of the TLR family, since it lacks the components that are normally required for signal transduction by other TLRs. Therefore the CD180/MD 1 complex has been considered of being incapable of independently initiating cellular signals. Using chemogenetic approaches we identified specifically the membrane bound long form of PIM-1 kinase, PIM-1L as the mediator of CD180-dependent signaling. A dominant negative isoform of PIM-1L, but not of other PIM kinases, inhibited signaling elicited by cross-linking of CD180, and this effect was phenocopied by PIM inhibitors. PIM-1L was directed to the cell membrane by its N-terminal extension, where it colocalized and physically associated with CD180. Triggering CD180 also induced increased phosphorylation of the anti-apoptotic protein BAD in a PIM kinase-dependent fashion. Also in primary human B cells, which are the main cells expressing CD180 in man, cross-linking of CD180 by monoclonal antibodies stimulated cell survival and proliferation that was abrogated by specific inhibitors. By associating with PIM-1L, CD180 can thus obtain autonomous signaling capabilities, and this complex is then channeling inflammatory signals into B cell survival programs. Pharmacological inhibition of PIM-1 should therefore provide novel therapeutic options in diseases that respond to innate immune stimulation with subsequently increased B cell activity, such as lupus erythematosus or myasthenia gravis.

  3. Planar Integrated Magnetics (PIM) Module in Hybrid Bidirectional DC-DC Converter for Fuel Cell Application

    DEFF Research Database (Denmark)

    Ouyang, Ziwei; Zhang, Zhe; Thomsen, Ole Cornelius

    2011-01-01

    , hereby increasing the power density of converters. In this paper, a new planar integrated magnetics (PIM) module for a phase-shift plus duty cycle controlled hybrid bi-directional dc-dc converter is proposed, which assembles one boost inductor and two transformers into an E-I-E core geometry, reducing...... and theoretical analysis, a lab prototype employing the PIM module is implemented for a fuel cell application with 20~40 V input voltage and 400 V output voltage. Detailed results from the experimental comparisons demonstrate that the PIM module is fully functional and electromagnetically equivalent...

  4. The characteristic shape of emission profiles of plasma spokes in HiPIMS: the role of secondary electrons

    CERN Document Server

    Hecimovic, A; Brinkmann, R -P; Böke, M; Winter, J

    2013-01-01

    A time resolved analysis of the emission of HiPIMS plasmas reveals inhomogeneities in the form of rotating spokes. The shape of these spokes is very characteristic depending on the target material. The localized enhanced light emission has been correlated with the ion production. Based on these data, the peculiar shape of the emission profiles can be explained by the localized generation of secondary electrons, resulting in an energetic electron pressure exceeding the magnetic pressure. This general picture is able to explain the observed emission profile for different target materials including gas rarefaction and second ionization potential of the sputtered elements.

  5. Finite-time control of DC-DC buck converters via integral terminal sliding modes

    Science.gov (United States)

    Chiu, Chian-Song; Shen, Chih-Teng

    2012-05-01

    This article presents novel terminal sliding modes for finite-time output tracking control of DC-DC buck converters. Instead of using traditional singular terminal sliding mode, two integral terminal sliding modes are introduced for robust output voltage tracking of uncertain buck converters. Different from traditional sliding mode control (SMC), the proposed controller assures finite convergence time for the tracking error and integral tracking error. Furthermore, the singular problem in traditional terminal SMC is removed from this article. When considering worse modelling, adaptive integral terminal SMC is derived to guarantee finite-time convergence under more relaxed stability conditions. In addition, several experiments show better start-up performance and robustness.

  6. Amplification of Quantum Meson Modes in the Late Time of the Chiral Phase Transition

    CERN Document Server

    Watanabe, K

    2007-01-01

    We investigate the time evolution of the quantum meson modes in the late time of chiral phase transition. In particular, it is shown that there exists a possible solution to the equation of motion for the quantum meson modes, which reveals a parametric resonance and/or resonance through forced oscillation induced by the small oscillation of the chiral condensate. After that, we demonstrate the unstable regions for the quantum meson modes in both the cases of a uniform and spatially expanding system.

  7. Efektivitas Layanan Weekend Banking (Studi BMI KCP PIM .

    Directory of Open Access Journals (Sweden)

    Rifa Farhah

    2014-01-01

    Full Text Available The Effectiveness of Weekend Banking Services (Study at BMI KCP PIM. The aim of this research is to analyze the effectiveness of weekend banking services at Bank Muamalat Indonesia. The method that used in this research is linier regression and. The result shown that the value of adjusted R-squared was 0.313409. It means that customer’s preference (dependent variable was influenced by location, brand image, and, product and services in the amount of 31.34% and the others 68.66% was influenced by the others factor. From the paired sample t-test shown that the weekend banking services still not effective to increase the third party funds  DOI:10.15408/aiq.v6i1.1370

  8. Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.

    Science.gov (United States)

    Ren, Ke; Zhang, Wei; Shi, Yujun; Gong, Jianping

    2010-06-01

    Pim-2 is proved to be relevant to the tumorigenesis of hepatocellular carcinoma (HCC), but the mechanism is unclear. We studied the relationship among Pim-2, NF-kappaB and API-5. In our experiment, expression level of the three factors and phosphorylation level of API-5, as well as NF-kappaB activity, were detected in HCC tissues and the nontumorous controls. Then Pim-2 gene was transfected into nontumorous liver cells L02, and Pim-2 SiRNA was transfected into hepatoblastoma cell line HepG2. Parthenolide was added as NF-kappaB inhibitor. The same detections as above were repeated in the cells, along with the apoptosis analysis. We found the levels of Pim-2, NF-kappaB and API-5, as well as NF-kappaB activity, were significantly higher in HCC tissues. Pim-2 level was increased in L02 cells after the transfection of Pim-2 gene, but decreased in HepG2 cells after the transfection of Pim-2 SiRNA. The levels of NF-kappaB and API-5, as well as NF-kappaB activity and API-5 phosphorylation level, were in accordance with Pim-2 level, but could be reversed by Parthenolide. Cell apoptosis rates were negatively correlated with API-5 phosphorylation level. Therefore, we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator.

  9. A NEW SLIDING MODE CONTROL FOR A CLASS OF UNCERTAIN TIME-DELAY CHAOTIC SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    LI LI-XIANG; PENG HAI-PENG; GUAN BAO-ZHU; XU JIN-MING

    2001-01-01

    We propose a new sliding mode control scheme for a class of uncertain time-delay chaotic systems. It is shown that a linear time invariant system with the desired system dynamics is used as a reference model for the output of a time-delay chaotic system to track. A sliding mode controller is then designed to drive the output of the time-delay chaotic system to track the desired linear system. On the sliding mode, the output of the controlled time-delay chaotic system can behave like the desired linear system. A simulation example is given in support of the proposed control scheme.

  10. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

    Directory of Open Access Journals (Sweden)

    Hastie C James

    2006-01-01

    Full Text Available Abstract Background Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers. Results Here we show that the pim kinases are constitutively active when expressed in HEK-293 cells and are able to phosphorylate the Bcl-2 family member Bad on three residues, Ser112, Ser136 and Ser155 in vitro and in cells. In vitro mapping showed that Pim-2 predominantly phosphorylated Ser112, while Pim-1 phosphorylated Ser112, but also Ser136 and Ser155 at a reduced rate compared to Ser112. Pim-3 was found to be the least specific for Ser112, and the most effective at phosphorylating Ser136 and Ser155. Pim-3 was also able to phosphorylate other sites in Bad in vitro, including Ser170, another potential in vivo site. Mutation of Ser136 to alanine prevented the phosphorylation of Ser112 and Ser155 by Pim kinases in HEK-293 cells, suggesting that this site must be phosphorylated first in order to make the other sites accessible. Pim phosphorylation of Bad was also found to promote the 14-3-3 binding of Bad and block its association with Bcl-XL. Conclusion All three Pim kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK-293 cells. This would be consistent with the proposed function of Pim kinases in promoting cell proliferation and preventing cell death.

  11. Bahamas Sea Water Temperature Data 1988-2003, PIMS Environmental Monitoring Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This metadata record references seawater temperature data collected at various sites and depths in the vicinity of PIMS research station on Lee Stocking Island,...

  12. Quantum dynamics through conical intersections in macrosystems: Combining effective modes and time-dependent Hartree

    Science.gov (United States)

    Basler, Mathias; Gindensperger, Etienne; Meyer, Hans-Dieter; Cederbaum, Lorenz S.

    2008-05-01

    We address the nonadiabatic quantum dynamics of (macro)systems involving a vast number of nuclear degrees of freedom (modes) in the presence of conical intersections. The macrosystem is first decomposed into a system part carrying a few, strongly coupled modes, and an environment, comprising the remaining modes. By successively transforming the modes of the environment, a hierarchy of effective Hamiltonians for the environment can be constructed. Each effective Hamiltonian depends on a reduced number of effective modes, which carry cumulative effects. The environment is described by a few effective modes augmented by a residual environment. In practice, the effective modes can be added to the system's modes and the quantum dynamics of the entire macrosystem can be accurately calculated on a limited time-interval. For longer times, however, the residual environment plays a role. We investigate the possibility to treat fully quantum mechanically the system plus a few effective environmental modes, augmented by the dynamics of the residual environment treated by the time-dependent Hartree (TDH) approximation. While the TDH approximation is known to fail to correctly reproduce the dynamics in the presence of conical intersections, it is shown that its use on top of the effective-mode formalism leads to much better results. Two numerical examples are presented and discussed; one of them is known to be a critical case for the TDH approximation.

  13. Finite-time stability and stabilization for stochastic markov jump systems with mode-dependent time delays.

    Science.gov (United States)

    Yan, Zhiguo; Song, Yunxia; Park, Ju H

    2017-05-01

    This paper is concerned with the problems of finite-time stability and stabilization for stochastic Markov systems with mode-dependent time-delays. In order to reduce conservatism, a mode-dependent approach is utilized. Based on the derived stability conditions, state-feedback controller and observer-based controller are designed, respectively. A new N-mode algorithm is given to obtain the maximum value of time-delay. Finally, an example is used to show the merit of the proposed results. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Time on Task in Intensive Modes of Delivery

    Science.gov (United States)

    Kuiper, Alison; Solomonides, Ian; Hardy, Lara

    2015-01-01

    This paper reports on an investigation into how staff teaching in compressed courses can encourage student engagement and enhance student use of learning time, despite significant restraints of time as well as distance. Typically these courses (described here as units) are expected to have comparable learning outcomes to their full-semester…

  15. Logarithmic modes of critical gravity in de Sitter space-time

    CERN Document Server

    Setare, M R

    2012-01-01

    In this paper we consider the critical gravity in four dimensional de Sitter space-time. We obtain logarithmic modes in the critical point of the theory. Then we show that these logarithmic modes in de Sitter space-time obey similar properties as the ones in AdS-space-time. Our result in this paper indicate that critical gravity theories in de Sitter space-times could lead to a de Sitter/log CFT correspondence.

  16. Simultaneous electrical and optical study of spoke rotation, merging and splitting in HiPIMS plasma

    Science.gov (United States)

    Klein, P.; Lockwood Estrin, F.; Hnilica, J.; Vašina, P.; Bradley, J. W.

    2017-01-01

    To gain more information on the temporal and spatial behaviour of self-organized spoke structures in HiPIMS plasmas, a correlation between the broadband optical image of an individual spoke (taken over 200 ns) and the current it delivers to the target has been made for a range of magnetron operating conditions. As a spoke passes over a set of embedded probes in the niobium cathode target, a distinct modulation in the local current density is observed, (typically up to twice the average value), matching very well the radially integrated optical emission intensities (obtained remotely with an ICCD camera). The dual diagnostic system allows the merging and splitting of a set of spokes to be studied as they rotate. It is observed that in the merger of two spokes, the trailing spoke maintains its velocity while the leading spoke either decreases its velocity or increases its azimuthal length. In the spoke splitting process, the total charge collected by an embedded probe is conserved. A simple phenomenological model is developed that relates the spoke mode number m to the spoke dimensions, spoke velocity and gas atom velocity. The results are discussed in the context of the observations of spoke dynamics made by Hecimovic et al (2015 Plasma Sources Sci. Technol. 24 045005)

  17. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation.

    Science.gov (United States)

    Din, Shabana; Mason, Matthew; Völkers, Mirko; Johnson, Bevan; Cottage, Christopher T; Wang, Zeping; Joyo, Anya Y; Quijada, Pearl; Erhardt, Peter; Magnuson, Nancy S; Konstandin, Mathias H; Sussman, Mark A

    2013-04-09

    Mitochondrial morphological dynamics affect the outcome of ischemic heart damage and pathogenesis. Recently, mitochondrial fission protein dynamin-related protein 1 (Drp1) has been identified as a mediator of mitochondrial morphological changes and cell death during cardiac ischemic injury. In this study, we report a unique relationship between Pim-1 activity and Drp1 regulation of mitochondrial morphology in cardiomyocytes challenged by ischemic stress. Transgenic hearts overexpressing cardiac Pim-1 display reduction of total Drp1 protein levels, increased phosphorylation of Drp1-(S637), and inhibition of Drp1 localization to the mitochondria. Consistent with these findings, adenoviral-induced Pim-1 neonatal rat cardiomyocytes (NRCMs) retain a reticular mitochondrial phenotype after simulated ischemia (sI) and decreased Drp1 mitochondrial sequestration. Interestingly, adenovirus Pim-dominant negative NRCMs show increased expression of Bcl-2 homology 3 (BH3)-only protein p53 up-regulated modulator of apoptosis (PUMA), which has been previously shown to induce Drp1 accumulation at mitochondria and increase sensitivity to apoptotic stimuli. Overexpression of the p53 up-regulated modulator of apoptosis-dominant negative adenovirus attenuates localization of Drp1 to mitochondria in adenovirus Pim-dominant negative NRCMs promotes reticular mitochondrial morphology and inhibits cell death during sI. Therefore, Pim-1 activity prevents Drp1 compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI.

  18. A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.

    Science.gov (United States)

    Mori, Mattia; Tintori, Cristina; Christopher, Robert Selwyne Arul; Radi, Marco; Schenone, Silvia; Musumeci, Francesca; Brullo, Chiara; Sanità, Patrizia; Delle Monache, Simona; Angelucci, Adriano; Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni; Botta, Maurizio

    2013-03-01

    Pim-1 is a serine/threonine kinase critically involved in the initiation and progression of various types of cancer, especially leukemia, lymphomas and solid tumors such as prostate, pancreas and colon, and is considered a potential drug target against these malignancies. In an effort to discover new potent Pim-1 inhibitors, a previously identified ATP-competitive indolyl-pyrrolone scaffold was expanded to derive structure-activity relationship data. A virtual screening campaign was also performed, which led to the discovery of additional ATP-competitive inhibitors as well as a series of 2-aminothiazole derivatives, which are noncompetitive with respect to both ATP and peptide substrate. This mechanism of action, which resembles allosteric inhibition, has not previously been characterized for Pim-1. Notably, further evaluation of the 2-aminothiazoles indicated a synergistic inhibitory effect in enzymatic assays when tested in combination with ATP-competitive inhibitors. A synergistic effect in the inhibition of cell proliferation by ATP-competitive and ATP-noncompetitive compounds was also observed in prostate cancer cell lines (PC3), where all Pim-1 inhibitors tested in showed synergism with the known anticancer agent, paclitaxel. These results further establish Pim-1 as a target in cancer therapy, and highlight the potential of these agents for use as adjuvant agents in the treatment of cancer diseases in which Pim-1 is associated with chemotherapeutic resistance.

  19. Synthesis and Transport Properties of Novel MOF/PIM-1/MOF Sandwich Membranes for Gas Separation

    Directory of Open Access Journals (Sweden)

    Alessio Fuoco

    2017-02-01

    Full Text Available Metal-organic frameworks (MOFs were supported on polymer membrane substrates for the fabrication of composite polymer membranes based on unmodified and modified polymer of intrinsic microporosity (PIM-1. Layers of two different MOFs, zeolitic imidazolate framework-8 (ZIF-8 and Copper benzene tricarboxylate ((HKUST-1, were grown onto neat PIM-1, amide surface-modified PIM-1 and hexamethylenediamine (HMDA -modified PIM-1. The surface-grown crystalline MOFs were characterized by a combination of several techniques, including powder X-ray diffraction, infrared spectroscopy and scanning electron microscopy to investigate the film morphology on the neat and modified PIM-1 membranes. The pure gas permeabilities of He, H2, O2, N2, CH4, CO2 were studied to understand the effect of the surface modification on the basic transport properties and evaluate the potential use of these membranes for industrially relevant gas separations. The pure gas transport was discussed in terms of permeability and selectivity, highlighting the effect of the MOF growth on the diffusion coefficients of the gas in the new composite polymer membranes. The results confirm that the growth of MOFs on polymer membranes can enhance the selectivity of the appropriately functionalized PIM-1, without a dramatic decrease of the permeability.

  20. The putative oncogene Pim-1 in the mouse: its linkage and variation among t haplotypes.

    Science.gov (United States)

    Nadeau, J H; Phillips, S J

    1987-11-01

    Pim-1, a putative oncogene involved in T-cell lymphomagenesis, was mapped between the pseudo-alpha globin gene Hba-4ps and the alpha-crystallin gene Crya-1 on mouse chromosome 17 and therefore within the t complex. Pim-1 restriction fragment variants were identified among t haplotypes. Analysis of restriction fragment sizes obtained with 12 endonucleases demonstrated that the Pim-1 genes in some t haplotypes were indistinguishable from the sizes for the Pim-1b allele in BALB/c inbred mice. There are now three genes, Pim-1, Crya-1 and H-2 I-E, that vary among independently derived t haplotypes and that have indistinguishable alleles in t haplotypes and inbred strains. These genes are closely linked within the distal inversion of the t complex. Because it is unlikely that these variants arose independently in t haplotypes and their wild-type homologues, we propose that an exchange of chromosomal segments, probably through double crossingover, was responsible for indistinguishable Pim-1 genes shared by certain t haplotypes and their wild-type homologues. There was, however, no apparent association between variant alleles of these three genes among t haplotypes as would be expected if a single exchange introduced these alleles into t haplotypes. If these variant alleles can be shown to be identical to the wild-type allele, then lack of association suggests that multiple exchanges have occurred during the evolution of the t complex.

  1. Synthesis and Transport Properties of Novel MOF/PIM-1/MOF Sandwich Membranes for Gas Separation.

    Science.gov (United States)

    Fuoco, Alessio; Khdhayyer, Muhanned R; Attfield, Martin P; Esposito, Elisa; Jansen, Johannes C; Budd, Peter M

    2017-02-11

    Metal-organic frameworks (MOFs) were supported on polymer membrane substrates for the fabrication of composite polymer membranes based on unmodified and modified polymer of intrinsic microporosity (PIM-1). Layers of two different MOFs, zeolitic imidazolate framework-8 (ZIF-8) and Copper benzene tricarboxylate ((HKUST-1), were grown onto neat PIM-1, amide surface-modified PIM-1 and hexamethylenediamine (HMDA) -modified PIM-1. The surface-grown crystalline MOFs were characterized by a combination of several techniques, including powder X-ray diffraction, infrared spectroscopy and scanning electron microscopy to investigate the film morphology on the neat and modified PIM-1 membranes. The pure gas permeabilities of He, H₂, O₂, N₂, CH₄, CO₂ were studied to understand the effect of the surface modification on the basic transport properties and evaluate the potential use of these membranes for industrially relevant gas separations. The pure gas transport was discussed in terms of permeability and selectivity, highlighting the effect of the MOF growth on the diffusion coefficients of the gas in the new composite polymer membranes. The results confirm that the growth of MOFs on polymer membranes can enhance the selectivity of the appropriately functionalized PIM-1, without a dramatic decrease of the permeability.

  2. Azide-based cross-linking of polymers of intrinsic microporosity (PIMs) for condensable gas separation

    KAUST Repository

    Du, Naiying

    2011-03-11

    Cross-linked polymers of intrinsic microporosity (PIM)s for gas separation membranes, were prepared by a nitrene reaction from a representative PIM in the presence of two different diazide cross-linkers. The reaction temperature was optimized using TGA. The homogenous membranes were cast from THF solutions of different ratios of PIM to azides. The resulting cross-linked structures of the PIMs membranes were formed at 175 °C after 7.5 h and confirmed by TGA, XPS, FT-IR spectroscopy and gel content analysis. These resulting cross-linked polymeric membranes showed excellent gas separation performance and can be used for O 2/N 2 and CO 2/N 2 gas pairs, as well as for condensable gases, such as CO 2/CH 4, propylene/propane separation. Most importantly, and differently from typical gas separation membranes derived from glassy polymers, the crosslinked PIMs showed no obvious CO 2 plasticization up to 20 atm pressure of pure CO 2 and CO 2/CH 4 mixtures. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. A Practical Approach to Mode Change in Real-Time Systems

    DEFF Research Database (Denmark)

    Søndergaard, Hans; Ravn, Anders Peter; Thomsen, Bent

    We present a contract for consistent mode change in a real-time system for control applications. The contract between the control engineer and the software developer guarantees that when a mode change is signalled, it will occur at a specific instant thereafter, and that the task sets for the modes...... are never mixed. The concept is illustrated by small examples, and efficient implementations in Safety Critical Java on two platforms are demonstrated....

  4. Test of High Time Resolution MRPC with Different Readout Modes

    CERN Document Server

    Yang, S; Li, C; Heng, Y K; Qian, S; Chen, H F; Chen, T X; Dai, H L; Fan, H H; Liu, S B; Liu, S D; Jiang, X S; Shao, M; Tang, Z B; Zhang, H; Zhao, Z G

    2014-01-01

    In order to further enhance the particle identification capability of the Beijing Spectrometer (BESIII), it is proposed to upgrade the current end-cap time-of-flight (eTOF) detector with multi-gap resistive plate chamber (MRPC). The prototypes, together with the front end electronics (FEE) and time digitizer (TDIG) module have been tested at the E3 line of Beijing Electron Positron Collider (BEPCII) to study the difference between the single and double-end readout MRPC designs. The time resolutions (sigma) of the single-end readout MRPC are 47/53 ps obtained by 600 MeV/c proton/pion beam, while that of the double-end readout MRPC is 40 ps (proton beam). The efficiencies of three MRPC modules tested by both proton and pion beam are better than 98%. For the double-end readout MRPC, no incident position dependence is observed.

  5. Preparation and application of polymer inclusion membranes (PIMs) including alamine 336 for the extraction of metals from an aqueous solution: Priprava in uporaba membrane iz polimera (PIM) in alamina 336 za ločenje kovin iz vodnih raztopin:

    OpenAIRE

    2014-01-01

    Polymer inclusion membranes (PIMs) present an attractive approach for the separation of metals from an aqueous solution. The present study is about the application of Alamine 336 as an ion carrier in PIMs. The separation of copper (II), cobalt (II), nickel (II) and cadmium (II) from aqueous solutions with polymer inclusion membranes was investigated. PIMs are formed by casting a solution containing a carrier (extractant), a plasticizer and a base polymer, such as cellulose tri-acetate (CTA) o...

  6. The Very Model of a Modern PI-Mode Structure

    CERN Multimedia

    Katarina Anthony

    2014-01-01

    Linac4's PI-Mode Structures (PIMS) are the first structures of their kind to accelerate protons. Now, over three years after work began on production, over 180 PIMS elements have been rough-machined and the first new PIMS cavity is being assembled at CERN.   The newly assembled PIMS cavity undergoes testing in CERN's Main Workshop. As the final accelerating structures of Linac4, located 53 m to 74 m downstream of the source, the state-of-the-art PIMS cavities will take protons from 100 to 160 MeV. While the first cavity was built entirely at CERN, construction of the remaining cavities has become a larger, multi-national operation. The newest PIMS cavity is being assembled and validated at CERN's Main Workshop. Built in collaboration with the National Centre for Nuclear Research (NCBJ, Poland) and the Jülich Research Centre (Germany), it is the first of its kind to be produced outside the Organization. Sharing all the required know...

  7. A current-mode buck DC-DC controller with adaptive on-time control

    Energy Technology Data Exchange (ETDEWEB)

    Li Yanming; Lai Xinquan; Ye Qiang; Yuan Bing; Chen Fuji [Institute of Electronic CAD, Xidian University, Xi' an 710071 (China); Jia Xinzhang, E-mail: ymli2004@126.co, E-mail: xqlai@mail.xidian.edu.c [Microelectronics Institute, Xidian University, Xi' an 710071 (China)

    2009-02-15

    A current-mode buck DC-DC controller based on adaptive on-time (AOT) control is presented. The on-time is obtained by the techniques of input feedforward and output feedback, and the adaptive control is achieved by a sample-hold and time-ahead circuit. The AOT current-mode control scheme not only obtains excellent transient response speed, but also achieves the independence of loop stability on output capacitor ESR. In addition, the AOT current-mode control does not have subharmonic oscillation phenomenon seen in fixed frequency peak current-mode control, so there is no need of the slope compensation circuit. The auto-skip pulse frequency modulation (PFM) mode improves the conversion efficiency of light load effectively. The controller has been fabricated with UMC 0.6-mum BCD process successfully and the detailed experimental results are shown.

  8. On spurious resonant modes in the MOT solution of time domain EFIE

    KAUST Repository

    Shi, Yifei

    2013-07-01

    Theoretically, internal resonant modes should not be induced in the marching-on-in-time (MOT) solution of the time domain electric field integral equation since zero initial conditions are enforced at the beginning of time marching and the internal resonant modes do not satisfy these initial conditions. However, these spurious modes are always observed in the MOT solution. It has been conjectured in the past that numerical errors might establish the necessary initial conditions and allow the incident field to induce the internal resonant modes. Systematic numerical experiments carried out in this work prove this conjecture by demonstrating that the internal resonant modes\\' amplitudes are indeed dictated by the numerical errors and the spectrum of the incident field. © 2013 IEEE.

  9. Robust sliding mode control for uncertain discrete time systems

    Institute of Scientific and Technical Information of China (English)

    QU Shaocheng; WANG Yongji

    2003-01-01

    A novel variable structure control (VSC) strategy with a dynamic disturbance compensator based on the reaching law for a class of uncertain discrete systems is presented. The robust stability to disturbance and the system dynamics in the vicinity of the switching plane are studied. A measure of the uncertain parameters and external disturbance is obtained through delaying every sampling time. Theoretical analysis and experimental simulation results demonstrate that the dynamic performance and robustness of the closed-loop system are improved effectively.

  10. Mode suppression in the non-Markovian limit by time-gated stimulated photon echo

    NARCIS (Netherlands)

    de Boeij, W.P.; Pshenichnikov, M.S; Wiersma, D. A.

    1996-01-01

    It is demonstrated that enhanced mode suppression in stimulated photon echo experiments can be obtained by diagonal time gating of the echo. This technique is especially important when the optical dynamics of the system is non-Markovian. A two-mode Brownian oscillator model is used to analyze the ef

  11. Time-domain multimode dispersion measurement in a higher-order-mode fiber.

    Science.gov (United States)

    Cheng, Ji; Pedersen, Martin E V; Wang, Ke; Xu, Chris; Grüner-Nielsen, Lars; Jakobsen, Dan

    2012-02-01

    We present a new multimode dispersion measurement technique based on the time-of-flight method. The modal delay and group velocity dispersion of all excited modes in a few-mode fiber can be measured simultaneously by a tunable pulsed laser and a high speed sampling oscilloscope. A newly designed higher-order-mode fiber with large anomalous dispersion in the LP(02) mode has been characterized using this method, and experimental results are in good agreement with the designed dispersion values. The demonstrated technique is significantly simpler to implement than the existing frequency-domain or interferometry-based methods.

  12. Between-mode-differences in the value of travel time: Self-selection or strategic behaviour?

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; Hjorth, Katrine; Lyk-Jensen, Stéphanie Vincent

    2010-01-01

    Using stated preference survey data, we measure the value of travel time for several transport modes. We find, like many before us, that the value of travel time varies across modes in the opposite direction of what would be the consequence of differences in comfort. We examine three candidate...... causes for the observed differences: Comfort effects, self-selection and strategic behaviour of respondents. Using experiments with both the current and an alternative mode we find that the differences in the value of travel time are consistent with self-selection and comfort effects. Moreover...

  13. Pim-2 protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via downregulation of Bim expression.

    Science.gov (United States)

    Xu, Yan; Xing, Yawei; Xu, Yanjie; Huang, Chahua; Bao, Huihui; Hong, Kui; Cheng, Xiaoshu

    2016-12-01

    We know that silencing Bim, a pro-apoptosis protein, significantly attenuates glucose and oxygen-deprived induced apoptosis in cardiomyocytes. However, the mechanisms underlying the regulation of the Bim activation in the heart have remained unknown. Pim-2 is one of three Pim serine/threonine kinase family members thought to be involved in cell survival and proliferation. H9c2 cardiomyocytes were subjected to a hypoxia/reoxygenation (H/R) condition in vitro, mimicking ischemic/reperfusion injury in vivo. H/R augmented the expression of Bim, Cyt C, and Pim-2 and induced H9c2 cell apoptosis. Overexpression of Pim-2 attenuated apoptosis which induced by H/R in H9c2 cells, via downregulation of Bim and Cyt C expression. Silencing of Pim-2 promoted H/R-induced apoptosis via upregulation of Bim and Cyt C expression. Co-IP revealed the interaction between Pim-2 and Bim protein, with Bim Ser(65) phosphorylated by Pim-2. Furthermore, blocking proteasome activity by MG132 prevented Bim degradation, and Bim S65A mutation could reverse the anti-apoptotic role of Pim-2 which induced by H/R. These data demonstrated that Pim-2 is a novel Bim-interacting protein, which negatively regulates Bim degradation and protects H9c2 cardiomyocytes from H/R-induced apoptosis.

  14. The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.

    Science.gov (United States)

    Wang, Hui-Ling; Cee, Victor J; Chavez, Frank; Lanman, Brian A; Reed, Anthony B; Wu, Bin; Guerrero, Nadia; Lipford, J Russell; Sastri, Christine; Winston, Jeff; Andrews, Kristin L; Huang, Xin; Lee, Matthew R; Mohr, Christopher; Xu, Yang; Zhou, Yihong; Tasker, Andrew S

    2015-02-15

    The three Pim kinases are a small family of serine/threonine kinases regulating several signaling pathways that are fundamental to tumorigenesis. As such, the Pim kinases are a very attractive target for pharmacological inhibition in cancer therapy. Herein, we describe our efforts toward the development of a potent, pan-Pim inhibitor. The synthesis and hit-to-lead SAR development from a 3-(pyrazin-2-yl)-1H-indazole derived hit 2 to the identification of a series of potent, pan-Pim inhibitors such as 13o are described.

  15. Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.

    Science.gov (United States)

    Korduláková, Jana; Gilleron, Martine; Mikusova, Katarína; Puzo, Germain; Brennan, Patrick J; Gicquel, Brigitte; Jackson, Mary

    2002-08-30

    We examined the function of the pimA (Rv2610c) gene, located in the vicinity of the phosphatidylinositol synthase gene in the genomes of Mycobacterium tuberculosis and Mycobacterium smegmatis, which encodes a putative mannosyltransferase involved in the early steps of phosphatidylinositol mannoside synthesis. A cell-free assay was developed in which membranes from M. smegmatis overexpressing the pimA gene incorporate mannose from GDP-[(14)C]Man into di- and tri-acylated phosphatidylinositol mono-mannosides. Moreover, crude extracts from Escherichia coli producing a recombinant PimA protein synthesized diacylated phosphatidylinositol mono-mannoside from GDP-[(14)C]Man and bovine phosphatidylinositol. To determine whether PimA is an essential enzyme of mycobacteria, we constructed a pimA conditional mutant of M. smegmatis. The ability of this mutant to synthesize the PimA mannosyltransferase was dependent on the presence of a functional copy of the pimA gene carried on a temperature-sensitive rescue plasmid. We demonstrate here that the pimA mutant is unable to grow at the higher temperature at which the rescue plasmid is lost. Thus, the synthesis of phosphatidylinositol mono-mannosides and derived higher phosphatidylinositol mannosides in M. smegmatis appears to be dependent on PimA and essential for growth. This work provides the first direct evidence of the essentiality of phosphatidylinositol mannosides for the growth of mycobacteria.

  16. Investigation of Timing to Switch Control Mode in Powered Knee Prostheses during Task Transitions.

    Directory of Open Access Journals (Sweden)

    Fan Zhang

    Full Text Available Current powered prosthetic legs require switching control modes according to the task the user is performing (e.g. level-ground walking, stair climbing, walking on slopes, etc.. To allow prosthesis users safely and seamlessly transition between tasks, it is critical to determine when to switch the prosthesis control mode during task transitions. Our previous study defined critical timings for different types of task transitions in ambulation; however, it is unknown whether it is the unique timing that allows safe and seamless transitions. The goals of this study were to (1 systematically investigate the effects of mode switch timing on the prosthesis user's performance in task transitions, and (2 identify appropriate timing to switch the prosthesis control mode so that the users can seamlessly transition between different locomotion tasks. Five able-bodied (AB and two transfemoral (TF amputee subjects were tested as they wore a powered knee prosthesis. The prosthesis control mode was switched manually at various times while the subjects performed different types of task transitions. The subjects' task transition performances were evaluated by their walking balance and success in performing seamless task transitions. The results demonstrated that there existed a time window within which switching the prosthesis control mode neither interrupted the subjects' task transitions nor disturbed their walking balance. Therefore, the results suggested the control mode switching of a lower limb prosthesis can be triggered within an appropriate time window instead of a specific timing or an individual phase. In addition, a generalized criterion to determine the appropriate mode switch timing was proposed. The outcomes of this study could provide important guidance for future designs of neurally controlled powered knee prostheses that are safe and reliable to use.

  17. Finite time control for MIMO nonlinear system based on higher-order sliding mode.

    Science.gov (United States)

    Liu, Xiangjie; Han, Yaozhen

    2014-11-01

    Considering a class of MIMO uncertain nonlinear system, a novel finite time stable control algorithm is proposed based on higher-order sliding mode concept. The higher-order sliding mode control problem of MIMO nonlinear system is firstly transformed into finite time stability problem of multivariable system. Then continuous control law, which can guarantee finite time stabilization of nominal integral chain system, is employed. The second-order sliding mode is used to overcome the system uncertainties. High frequency chattering phenomenon of sliding mode is greatly weakened, and the arbitrarily fast convergence is reached. The finite time stability is proved based on the quadratic form Lyapunov function. Examples concerning the triple integral chain system with uncertainty and the hovercraft trajectory tracking are simulated respectively to verify the effectiveness and the robustness of the proposed algorithm.

  18. The Plasma Instrument for Magnetic Sounding (PIMS) on The Europa Clipper Mission

    Science.gov (United States)

    Westlake, Joseph H.; McNutt, Ralph L.; Kasper, Justin C.; Case, Anthony W.; Grey, Matthew P.; Kim, Cindy K.; Battista, Corina C.; Rymer, Abigail; Paty, Carol S.; Jia, Xianzhe; Stevens, Michael L.; Khurana, Krishan; Kivelson, Margaret G.; Slavin, James A.; Korth, Haje H.; Smith, Howard T.; Krupp, Norbert; Roussos, Elias; Saur, Joachim

    2016-10-01

    The Europa Clipper mission is equipped with a sophisticated suite of 9 instruments to study Europa's interior and ocean, geology, chemistry, and habitability from a Jupiter orbiting spacecraft. The Plasma Instrument for Magnetic Sounding (PIMS) on Europa Clipper is a Faraday Cup based plasma instrument whose heritage dates back to the Voyager spacecraft. PIMS will measure the plasma that populates Jupiter's magnetosphere and Europa's ionosphere. The science goals of PIMS are to: 1) estimate the ocean salinity and thickness by determining Europa's magnetic induction response, corrected for plasma contributions; 2) assess mechanisms responsible for weathering and releasing material from Europa's surface into the atmosphere and ionosphere; and 3) understand how Europa influences its local space environment and Jupiter's magnetosphere and vice versa.Europa is embedded in a complex Jovian magnetospheric plasma, which rotates with the tilted planetary field and interacts dynamically with Europa's ionosphere affecting the magnetic induction signal. Plasma from Io's temporally varying torus diffuses outward and mixes with the charged particles in Europa's own torus producing highly variable plasma conditions at Europa. PIMS works in conjunction with the Interior Characterization of Europa using Magnetometry (ICEMAG) investigation to probe Europa's subsurface ocean. This investigation exploits currents induced in Europa's interior by the moon's exposure to variable magnetic fields in the Jovian system to infer properties of Europa's subsurface ocean such as its depth, thickness, and conductivity. This technique was successfully applied to Galileo observations and demonstrated that Europa indeed has a subsurface ocean. While these Galileo observations contributed to the renewed interest in Europa, due to limitations in the observations the results raised major questions that remain unanswered. PIMS will greatly refine our understanding of Europa's global liquid ocean by

  19. Simulation of Neutral Particle Transport During HiPIMS

    Science.gov (United States)

    Trieschmann, Jan; Gallian, Sara; Brinkmann, Ralf Peter; Mussenbrock, Thomas

    2014-10-01

    In this work the importance of the knowledge of the spatial distribution, its temporal evolution as well as their energy distribution of heavy particles within sputtering processes is discussed. To describe these discharges - typically operated at very low pressures below 1 Pa - specific modeling approaches are required. Our approach comprises a three-dimensional kinetic Lagrangian description of neutral particles. A modified version of the direct simulation Monte Carlo (DSMC) code dsmcFoam is used, with the aim to describe the evolution of background and sputtered particles of a High Power Impulse Magnetron Sputtering (HiPIMS) process in a research reactor. Emphasize is put on the influence of the initial angular distribution of sputtered particles, as well as their energy distribution and its angular dependence. Based on the work of Stepanova and Dew a modified Thompson energy distribution is used. Differently distributed sputtered particles provide densities and fluxes concerning the corresponding film formation. This work is supported by the German Research Foundation in the frame of the Collaborative Research Centre TRR 87.

  20. Adaptive Fuzzy Sliding Mode Control of MEMS Gyroscope with Finite Time Convergence

    Directory of Open Access Journals (Sweden)

    Jianxin Ren

    2016-01-01

    Full Text Available This paper presents adaptive fuzzy finite time sliding mode control of microelectromechanical system gyroscope with uncertainty and external disturbance. Firstly, fuzzy system is employed to approximate the uncertainty nonlinear dynamics. Secondly, nonlinear sliding mode hypersurface and double exponential reaching law are selected to design the finite time convergent sliding mode controller. Thirdly, based on Lyapunov methods, adaptive laws are presented to adjust the fuzzy weights and the system can be guaranteed to be stable. Finally, the effectiveness of the proposed method is verified with simulation.

  1. H∞ Observer-Based Sliding Mode Control for Uncertain Stochastic Systems with Time-Varying Delays

    Directory of Open Access Journals (Sweden)

    Peng Zhang

    2013-01-01

    Full Text Available The paper is concerned with sliding mode control for uncertain time-delay systems subjected to input nonlinearity and stochastic perturbations. Using the sliding mode control, a robust law is derived to guarantee the reachability of the sliding surface in a finite time interval. The sufficient conditions on asymptotic stability of the error system and sliding mode dynamics with disturbance attenuation level are presented in terms of linear matrix inequalities (LMIs. Finally, an example is provided to illustrate the efficiency and effectiveness of the proposed method.

  2. Multiplexed single-mode wavelength-to-time mapping of multimode light

    Science.gov (United States)

    Chandrasekharan, Harikumar K.; Izdebski, Frauke; Gris-Sánchez, Itandehui; Krstajić, Nikola; Walker, Richard; Bridle, Helen L.; Dalgarno, Paul A.; MacPherson, William N.; Henderson, Robert K.; Birks, Tim A.; Thomson, Robert R.

    2017-01-01

    When an optical pulse propagates along an optical fibre, different wavelengths travel at different group velocities. As a result, wavelength information is converted into arrival-time information, a process known as wavelength-to-time mapping. This phenomenon is most cleanly observed using a single-mode fibre transmission line, where spatial mode dispersion is not present, but the use of such fibres restricts possible applications. Here we demonstrate that photonic lanterns based on tapered single-mode multicore fibres provide an efficient way to couple multimode light to an array of single-photon avalanche detectors, each of which has its own time-to-digital converter for time-correlated single-photon counting. Exploiting this capability, we demonstrate the multiplexed single-mode wavelength-to-time mapping of multimode light using a multicore fibre photonic lantern with 121 single-mode cores, coupled to 121 detectors on a 32 × 32 detector array. This work paves the way to efficient multimode wavelength-to-time mapping systems with the spectral performance of single-mode systems.

  3. Improved robustness and performance of discrete time sliding mode control systems.

    Science.gov (United States)

    Chakrabarty, Sohom; Bartoszewicz, Andrzej

    2016-11-01

    This paper presents a theoretical analysis along with simulations to show that increased robustness can be achieved for discrete time sliding mode control systems by choosing the sliding variable, or the output, to be of relative degree two instead of relative degree one. In other words it successfully reduces the ultimate bound of the sliding variable compared to the ultimate bound for standard discrete time sliding mode control systems. It is also found out that for such a selection of relative degree two output of the discrete time system, the reduced order system during sliding becomes finite time stable in absence of disturbance. With disturbance, it becomes finite time ultimately bounded.

  4. Low-temperature plasma nitriding of sintered PIM 316L austenitic stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, Aecio Fernando; Scheuer, Cristiano Jose; Joanidis, Ioanis Labhardt; Cardoso, Rodrigo Perito; Mafra, Marcio; Klein, Aloisio Nelmo; Brunatto, Silvio Francisco, E-mail: brunatto@ufpr.br [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Engenharia Mecanica. Grupo de Tecnologia de Fabricacao Assistida pro Plasma e Metalurgia do Po

    2014-08-15

    This work reports experimental results on sintered PIM 316L stainless steel low-temperature plasma nitriding. The effect of treatment temperature and time on process kinetics, microstructure and surface characteristics of the nitrided samples were investigated. Nitriding was carried out at temperatures of 350, 380, 410 and 440 °C , and times of 4, 8 and 16 h, using a gas mixture composed by 60% N2 + 20% H2 + 20% Ar, at a gas flow rate of 5.00 X 10{sup 6} Nm{sup 3-1}, and a pressure of 800 Pa. The treated samples were characterized by scanning electron microscopy, X-ray diffractometry and microhardness measurements. Results indicate that low-temperature plasma nitriding is a diffusion controlled process. The calculated activation energy for nitrided layer growth was 111.4 kJmol{sup -1}. Apparently precipitation-free layers were produced in this study. It was also observed that the higher the treatment temperature and time the higher is the obtained surface hardness. Hardness up to 1343 HV{sub 0.025} was verified for samples nitrided at 440 °C. Finally, the characterization of the treated surface indicates the formation of cracks, which were observed in regions adjacent to the original pores after the treatment. (author)

  5. On the DC loop modes in the MOT solution of the time domain EFIE

    KAUST Repository

    Shi, Yifei

    2014-07-01

    When marching-on-in-time (MOT) method is applied to solve the time domain electric field integral equation (TD-EFIE), DC loop modes are always observed in the solution. In theory these modes should not be observed since they do not satisfy the relaxed initial conditions. Their appearance is attributed to numerical errors. It is shown here that when Rao-Wilton-Glisson basis and Lagrange interpolation functions are used to discretize the TD-EFIE, errors due to this space-time discretization have zero impact on the DC loop modes. Numerical experiments demonstrate that the numerical errors due to approximate solution of the MOT matrix system have more dominant impact on DC loop modes in the MOT solution.

  6. Pim-3 contributes to radioresistance through regulation of the cell cycle and DNA damage repair in pancreatic cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xiang-Yuan; Wang, Zhen [Cancer Research Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Li, Bei [Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Zhang, Ying-Jian, E-mail: yjzhang111@aliyun.com [Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Li, Ying-Yi, E-mail: liyingyi@fudan.edu.cn [Cancer Research Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China)

    2016-04-22

    Resistance of cancer cells to chemoradiotherapy is a major clinical problem in pancreatic cancer treatment. Therefore, understanding the molecular basis of cellular resistance and identifying novel targets are essential for improving treatment efficacy for pancreatic cancer patients. Previous studies have demonstrated a significant role for Pim-3 in pancreatic cancer survival against gemcitabine-induced genotoxic stress. Here, we observed that radiation treatment enhanced Pim-3 expression in human pancreatic cancer cells in vitro. Stable overexpression of Pim-3 in pancreatic cancer cells significantly protected cells against radiation treatment by attenuating G2/M phase cell cycle arrest and DNA damage response. Silencing of Pim-3 expression significantly elevated the phosphorylation of histone variant H2AX, a marker of DNA double strand breaks, and decreased the activation of ataxia-telangiectasia-mutated (ATM) kinase, along with its downstream targets, eventually enhancing the radiosensitivity of human pancreatic cancer cells in vitro and in vivo. Hence, we demonstrated a novel function for Pim-3 in human pancreatic cancer cell survival against radiation. Targeting Pim-3 may be a promising way to improve treatment efficacy in combination with radiotherapy in human pancreatic cancer. - Highlights: • This is first study to demonstrate that Pim-3 is endogenously induced by ionizing radiation in pancreatic cancer cells, and Pim-3 overexpression enhanced radioresistance of pancreatic cancer cells both in vitro and in vivo. • This is first study to provide evidence that radioresistance induced by Pim-3 is mainly attributed to Pim-3 induces activation of ATM, which subsequently activates checkpoint 1, leading to amplification of DNA repair through cell cycle arrest and DNA repair pathways. • This is first study to indicate that targeting Pim-3 may be a promising strategy to provide better treatment efficacy in combination with radiotherapy in human pancreatic

  7. Advancements of labelled radio-pharmaceutics imaging with the PIM-MPGD

    Energy Technology Data Exchange (ETDEWEB)

    Donnard, J; Berny, R; Carduner, H; Leray, P; Morteau, E; Servagent, N; Thers, D [Subatech, in2p3/Ecole des Mines de Nantes/Universite de Nantes, La Chantrerie 4 rue Alfred Kastler BP 20722 44307 NANTES CEDEX 3 (France); Arlicot, N, E-mail: jerome.donnard@subatech.in2p3.f [INSERM U930 CNRS ERL 3106/Universite Francois Rabelais de Tours, CHRU Bretonneau 2 boulevard Tonnelle, 37044 TOURS CEDEX (France)

    2009-11-15

    The Beta autoradiography is widely used in pharmacology or in biological fields to study the response of an organism to a certain kind of molecule. The image of the distribution is processed by studying the concentration of the radioactivity into different organs. We report on the development of an integrated apparatus based on a PIM device (Parallel Ionization Multiplier) able to process the image of 10 microscope slides at the same time over an area of 18*18 cm{sup 2}. Thanks to a vacuum pump and a regulation gas circuit, 5 minutes is sufficient to begin an acquisition. All the electronics and the gas distribution are included in the structure leading to a transportable device. Special software has been developed to process data in real time with image visualization. Biological samples can be labelled with beta emitters of low energy like {sup 3}H/{sup 14}C or Auger electrons of {sup 125}I/{sup 99m}Tc. The measured spatial resolution is 30 mum in {sup 3}H and the trigger and the charge rate are constant over more than 6 days of acquisition showing good stability of the device. Moreover, collaboration with doctors and biologists of INSERM (National Institute for Medical Research in France) has started in order to demonstrate that MPGD's can be easily proposed outside a physics laboratory.

  8. Discrete sliding mode control for robust tracking of higher order delay time systems with experimental application.

    Science.gov (United States)

    Khandekar, A A; Malwatkar, G M; Patre, B M

    2013-01-01

    In this paper, a discrete time sliding mode controller (DSMC) is proposed for higher order plus delay time (HOPDT) processes. A sliding mode surface is selected as a function of system states and error and the tuning parameters of sliding mode controller are determined using dominant pole placement strategy. The condition for the existence of stable sliding mode is obtained by using Lyapunov function. The proposed method is applicable to HOPDT processes with oscillatory and integrating behavior, open loop instability or non-minimum phase characteristics and works satisfactory under the effect of parametric uncertainty. The method does not require reduced order model and provides simple way to design the controllers. The simulation and experimentation results show that the proposed method ensures desired tracking dynamics.

  9. Adaptive Output Feedback Sliding Mode Control for Complex Interconnected Time-Delay Systems

    Directory of Open Access Journals (Sweden)

    Van Van Huynh

    2015-01-01

    Full Text Available We extend the decentralized output feedback sliding mode control (SMC scheme to stabilize a class of complex interconnected time-delay systems. First, sufficient conditions in terms of linear matrix inequalities are derived such that the equivalent reduced-order system in the sliding mode is asymptotically stable. Second, based on a new lemma, a decentralized adaptive sliding mode controller is designed to guarantee the finite time reachability of the system states by using output feedback only. The advantage of the proposed method is that two major assumptions, which are required in most existing SMC approaches, are both released. These assumptions are (1 disturbances are bounded by a known function of outputs and (2 the sliding matrix satisfies a matrix equation that guarantees the sliding mode. Finally, a numerical example is used to demonstrate the efficacy of the method.

  10. Attosecond-resolution timing jitter characterization of free-running mode-locked lasers.

    Science.gov (United States)

    Kim, Jungwon; Chen, Jeff; Cox, Jonathan; Kärtner, Franz X

    2007-12-15

    Timing jitter characterization of optical pulse trains from free-running mode-locked lasers with attosecond resolution is demonstrated using balanced optical cross correlation in the timing detector and the timing delay configurations. In the timing detector configuration, the balanced cross correlation between two mode-locked lasers synchronized by a low-bandwidth phase-locked loop is used to measure the timing jitter spectral density outside the locking bandwidth. In addition, the timing delay configuration using a 325 m long timing-stabilized fiber link enables the characterization of timing jitter faster than the delay time. The limitation set by shot noise in this configuration is 2.2 x 10(-8) fs(2)/Hz corresponding to 470 as in 10 MHz bandwidth.

  11. Nonadiabatic analysis of strange-modes in hot massive stars with time-dependent convection

    Directory of Open Access Journals (Sweden)

    Sonoi Takafumi

    2015-01-01

    Full Text Available We carry out nonadiabatic analysis of strange-modes in hot massive stars with time-dependent convection (TDC. We find that the instability of the modes excited at the Fe bump is weaker with TDC than with frozen-in convection (FC. But the instability still remains with TDC, and could be a possible candidate for the trigger of luminous blue variable (LBV phenomena.

  12. Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model

    DEFF Research Database (Denmark)

    Agrawal-Singh, Shuchi; Koschmieder, Steffen; Gelsing, Sandra

    2010-01-01

    Although the potential role of Pim2 as a cooperative oncogene has been well described in lymphoma, its role in leukemia has remained largely unexplored. Here we show that high expression of Pim2 is observed in patients with acute promyelocytic leukemia (APL). To further characterize the cooperati...

  13. MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.

    Directory of Open Access Journals (Sweden)

    Kyu-Tae Kim

    Full Text Available Activating mutations in the receptor tyrosine kinase FLT3 are one of the most frequent somatic mutations in acute myeloid leukemia (AML. Internal tandem duplications of the juxtamembrane region of FLT3 (FLT3/ITD constitutively activate survival and proliferation pathways, and are associated with a poor prognosis in AML. We suspected that alteration of small non-coding microRNA (miRNA expression in these leukemia cells is involved in the transformation process and used miRNA microarrays to determine the miRNA signature from total RNA harvested from FLT3/ITD expressing FDC-P1 cells (FD-FLT3/ITD. This revealed that a limited set of miRNAs appeared to be affected by expression of FLT3/ITD compared to the control group consisting of FDC-P1 parental cells transfected with an empty vector (FD-EV. Among differentially expressed miRNAs, we selected miR-16, miR-21 and miR-223 to validate the microarray data by quantitative real-time RT-PCR showing a high degree of correlation. We further analyzed miR-16 expression with FLT3 inhibitors in FLT3/ITD expressing cells. MiR-16 was found to be one of most significantly down-regulated miRNAs in FLT3/ITD expressing cells and was up-regulated upon FLT3 inhibition. The data suggests that miR-16 is acting as a tumour suppressor gene in FLT3/ITD-mediated leukemic transformation. Whilst miR-16 has been reported to target multiple mRNAs, computer models from public bioinformatic resources predicted a potential regulatory mechanism between miR-16 and Pim-1 mRNA. In support of this interaction, miR-16 was shown to suppress Pim-1 reporter gene expression. Further, our data demonstrated that over-expression of miR-16 mimics suppressed Pim-1 expression in FD-FLT3/ITD cells suggesting that increased miR-16 expression contributes to depletion of Pim-1 after FLT3 inhibition and that miR-16 repression may be associated with up-regulated Pim-1 in FLT3/ITD expressing cells.

  14. Mode size and time duration fluctuations in a picosecond Nd:YAG laser

    Energy Technology Data Exchange (ETDEWEB)

    Cutolo, A.; Zeni, L.; Berardi, V.; Bruzzese, R.; Solimeno, S.; Spinelli, N.

    1989-05-15

    A new technique is successfully used to analyze in real time the pulse-to-pulse fluctuations of mode size and time duration in a picosecond Nd:YAG laser. In particular we show that the pulse length (30 psec) of our active--passive mode-locked Nd:YAG laser is stable to within 10% when the cavity is perfectly tuned and the saturable absorber is fresh. This technique is experimentally shown to be effective and reliable for real-time analysis of the stability of ultrashort laser pulses under a broad range of experimental conditions.

  15. Diagonal time gating of stimulated photon echo : vibrational mode suppression in the non-Markovian limit

    NARCIS (Netherlands)

    Pshenichnikov, Maxim S.; Boeij, Wim P. de; Wiersma, Douwe A.

    1996-01-01

    In this contribution we show that enhanced mode suppression can be obtained by time-gating the stimulated photon echo (SPE) at the conventional echo time and in phase with the wave packet dynamics. This novel technique is demonstrated on a dye solution of DTTCI in ethylene glycol. As it was directly

  16. PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

    Science.gov (United States)

    2011-01-01

    Background Facilities that provide a service for DNA sequencing typically support large numbers of users and experiment types. The cost of services is often reduced by the use of liquid handling robots but the efficiency of such facilities is hampered because the software for such robots does not usually integrate well with the systems that run the sequencing machines. Accordingly, there is a need for software systems capable of integrating different robotic systems and managing sample information for DNA sequencing services. In this paper, we describe an extension to the Protein Information Management System (PIMS) that is designed for DNA sequencing facilities. The new version of PIMS has a user-friendly web interface and integrates all aspects of the sequencing process, including sample submission, handling and tracking, together with capture and management of the data. Results The PIMS sequencing extension has been in production since July 2009 at the University of Leeds DNA Sequencing Facility. It has completely replaced manual data handling and simplified the tasks of data management and user communication. Samples from 45 groups have been processed with an average throughput of 10000 samples per month. The current version of the PIMS sequencing extension works with Applied Biosystems 3130XL 96-well plate sequencer and MWG 4204 or Aviso Theonyx liquid handling robots, but is readily adaptable for use with other combinations of robots. Conclusions PIMS has been extended to provide a user-friendly and integrated data management solution for DNA sequencing facilities that is accessed through a normal web browser and allows simultaneous access by multiple users as well as facility managers. The system integrates sequencing and liquid handling robots, manages the data flow, and provides remote access to the sequencing results. The software is freely available, for academic users, from http://www.pims-lims.org/. PMID:21385349

  17. PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities

    Directory of Open Access Journals (Sweden)

    Baldwin Stephen A

    2011-03-01

    Full Text Available Abstract Background Facilities that provide a service for DNA sequencing typically support large numbers of users and experiment types. The cost of services is often reduced by the use of liquid handling robots but the efficiency of such facilities is hampered because the software for such robots does not usually integrate well with the systems that run the sequencing machines. Accordingly, there is a need for software systems capable of integrating different robotic systems and managing sample information for DNA sequencing services. In this paper, we describe an extension to the Protein Information Management System (PIMS that is designed for DNA sequencing facilities. The new version of PIMS has a user-friendly web interface and integrates all aspects of the sequencing process, including sample submission, handling and tracking, together with capture and management of the data. Results The PIMS sequencing extension has been in production since July 2009 at the University of Leeds DNA Sequencing Facility. It has completely replaced manual data handling and simplified the tasks of data management and user communication. Samples from 45 groups have been processed with an average throughput of 10000 samples per month. The current version of the PIMS sequencing extension works with Applied Biosystems 3130XL 96-well plate sequencer and MWG 4204 or Aviso Theonyx liquid handling robots, but is readily adaptable for use with other combinations of robots. Conclusions PIMS has been extended to provide a user-friendly and integrated data management solution for DNA sequencing facilities that is accessed through a normal web browser and allows simultaneous access by multiple users as well as facility managers. The system integrates sequencing and liquid handling robots, manages the data flow, and provides remote access to the sequencing results. The software is freely available, for academic users, from http://www.pims-lims.org/.

  18. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

    Science.gov (United States)

    Cee, Victor J; Chavez, Frank; Herberich, Bradley; Lanman, Brian A; Pettus, Liping H; Reed, Anthony B; Wu, Bin; Wurz, Ryan P; Andrews, Kristin L; Chen, Jie; Hickman, Dean; Laszlo, Jimmy; Lee, Matthew R; Guerrero, Nadia; Mattson, Bethany K; Nguyen, Yen; Mohr, Christopher; Rex, Karen; Sastri, Christine E; Wang, Paul; Wu, Qiong; Wu, Tian; Xu, Yang; Zhou, Yihong; Winston, Jeffrey T; Lipford, J Russell; Tasker, Andrew S; Wang, Hui-Ling

    2016-04-14

    The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple myeloma. Starting from a moderately potent quinoxaline-dihydropyrrolopiperidinone lead, we recognized the potential for macrocyclization and developed a series of 13-membered macrocycles. The structure-activity relationships of the macrocyclic linker were systematically explored, leading to the identification of 9c as a potent, subnanomolar inhibitor of Pim-1 and -2. This molecule also potently inhibited Pim kinase activity in KMS-12-BM, a multiple myeloma cell line with relatively high endogenous levels of Pim-1/2, both in vitro (pBAD IC50 = 25 nM) and in vivo (pBAD EC50 = 30 nM, unbound), and a 100 mg/kg daily dose was found to completely arrest the growth of KMS-12-BM xenografts in mice.

  19. Perception of Not Having Enough Milk and Actual Milk Production of First-Time Breastfeeding Mothers: Is There a Difference?

    Science.gov (United States)

    Galipeau, Roseline; Dumas, Louise; Lepage, Mario

    2017-05-01

    This study aimed to determine the relationship between perceived insufficient milk supply (PIMS) and actual insufficient milk supply (AIMS) and the relative contributions of physiological and psychosocial variables on both PIMS and AIMS of first-time breastfeeding mothers. Data were collected among 123 breastfeeding mothers at a Canadian, French-speaking maternal care hospital. Birth events, breastfeeding practices, infant and maternal capacities, and PIMS and AIMS were collected at 48 hours after birth, postnatal weeks 2 and 6. No significant relationship was found between PIMS and AIMS. Maternal breastfeeding self-efficacy and number of feeds were related to PIMS at week 2, and skin-to-skin contact at birth and number of feeds were related to AIMS as measured by 24-hour milk production at week 2. Maternal breastfeeding self-efficacy impacts PIMS. Interventions should be directed to increase maternal confidence in breastfeeding, which in turn influences breastfeeding duration.

  20. Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.

    Science.gov (United States)

    Szydłowski, Maciej; Prochorec-Sobieszek, Monika; Szumera-Ciećkiewicz, Anna; Derezińska, Edyta; Hoser, Grażyna; Wasilewska, Danuta; Szymańska-Giemza, Olga; Jabłońska, Ewa; Białopiotrowicz, Emilia; Sewastianik, Tomasz; Polak, Anna; Czardybon, Wojciech; Gałęzowski, Michał; Windak, Renata; Zaucha, Jan Maciej; Warzocha, Krzysztof; Brzózka, Krzysztof; Juszczyński, Przemysław

    2017-09-21

    Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenvironment and allow tumor cells to evade immune surveillance. Expression of certain immunoregulatory proteins is modulated by prosurvival transcription factors, such as NFκB and STATs. Because these factors also induce expression of the oncogenic PIM1/2/3 serine/threonine kinases, and as PIMs modulate transcriptional activity of NFκB and STATs, we hypothesized that these kinases support RS cell survival and foster their immune privilege. Here, we investigated PIM1/2/3 expression in cHL and assessed their role in developing RS cell immune privilege and survival. PIM1/2/3 were ubiquitously expressed in primary and cultured RS cells, and their expression was driven by JAK-STAT and NFκB activity. Genetic or chemical PIM inhibition with a newly developed pan-PIM inhibitor, SEL24-B489, induced RS cell apoptosis. PIM inhibition decreased cap-dependent protein translation, blocked JAK-STAT signaling, and markedly attenuated NFκB-dependent gene expression. In a cHL xenograft model, SEL24-B489 delayed tumor growth by 95.8% (P = .0002). Furthermore, SEL24-B489 decreased the expression of multiple molecules engaged in developing the immunosuppressive microenvironment, including galectin-1 and PD-L1/2. In coculture experiments, T cells incubated with SEL24-B489-treated RS cells exhibited higher expression of activation markers than T cells coincubated with control RS cells. Taken together, our data indicate that PIM kinases in cHL exhibit pleiotropic effects, orchestrating tumor immune escape and supporting RS cell survival. Inhibition of PIM kinases decreases RS cell viability and disrupts signaling circuits that link these cells with their niches. Thus, PIM kinases are promising therapeutic targets in cHL. © 2017 by The American Society of Hematology.

  1. Genetic modelling of PIM proteins in cancer: proviral tagging, cooperation with oncogenes, tumor suppressor genes and carcinogens.

    Directory of Open Access Journals (Sweden)

    Enara eAguirre

    2014-05-01

    Full Text Available The PIM proteins, which were initially discovered as proviral insertion sites in Moloney murine leukemia virus infection, are a family of highly homologous serine/threonine kinases that have been reported to be overexpressed in hematological malignancies and solid tumors. The PIM proteins have also been associated with metastasis and overall treatment responses and implicated in the regulation of apoptosis, metabolism, the cell cycle, and homing and migration, which makes these proteins interesting targets for anticancer drug discovery. The use of retroviral insertional mutagenesis and refined approaches such as complementation tagging has allowed the identification of myc, pim and a third group of genes (including bmi1 and gfi1 as complementing genes in lymphomagenesis. Moreover, mouse modeling of human cancer has provided an understanding of the molecular pathways that are involved in tumor initiation and progression at the physiological level. In particular, genetically modified mice have allowed researchers to further elucidate the role of each of the Pim isoforms in various tumor types. PIM kinases have been identified as weak oncogenes because experimental overexpression in lymphoid tissue, prostate and liver induces tumors at a relatively low incidence and with a long latency. However, very strong synergistic tumorigenicity between Pim1/2 and c-Myc and other oncogenes has been observed in lymphoid tissues. Mouse models have also been used to study whether the inhibition of specific PIM isoforms is required to prevent carcinogen-induced sarcomas, indicating that the absence of Pim2 and Pim3 greatly reduces sarcoma growth and bone invasion; the extent of this effect is similar to that observed in the absence of all 3 isoforms. This review will summarize some of the animal models that have been used to understand the isoform-specific contribution of PIM kinases to tumorigenesis.

  2. Electrically Injected Single Transverse-Mode Coupled Waveguide Lasers by Parity-time (PT) Symmetry

    CERN Document Server

    Yao, Ruizhe; Podolskiy, Viktor; Guo, Wei

    2016-01-01

    In this report, we demonstrate the single transverse-mode operation of InAs quantum dot (QD) broad-area coupled waveguide lasers by parity-time (PT) symmetry. A novel waveguide design is adopted by adding gain and loss in the electrically injected coupled waveguide laser cavity. In such counterintuitive waveguide design, the single mode operation is achieved by harnessing notions from PT symmetry breaking and mode selections. By further varying the loss in the coupled waveguides, the coupled waveguide operation in different PT symmetry regions is experimentally demonstrated and agrees well with the numerical models. The demonstration of an electrically pumped single transverse-mode based on PT symmetry breaking paves a way to the next-generation optoelectronic devices and advanced laser science.

  3. Variable structure control with sliding mode prediction for discrete-time nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    Lingfei XIAO; Hongye SU; Xiaoyu ZHANG; Jian CHU

    2006-01-01

    A new variable structure control algorithm based on sliding mode prediction for a class of discrete-time nonlinear systems is presented. By employing a special model to predict future sliding mode value, and combining feedback correction and receding horizon optimization methods which are extensively applied on predictive control strategy, a discrete-time variable structure control law is constructed. The closed-loop systems are proved to have robustness to uncertainties with unspecified boundaries. Numerical simulation and pendulum experiment results illustrate that the closed-loop systems possess desired performance, such as strong robustness, fast convergence and chattering elimination.

  4. Integral sliding mode control for a class of nonlinear neutral systems with time-varying delays

    Institute of Scientific and Technical Information of China (English)

    Lou Xu-Yang; Cui Bao-Tong

    2008-01-01

    This paper focuses on sliding mode control problems for a class of nonlinear neutral systems with time-varying delays. An integral sliding surface is firstly constructed. Then it finds a useful criteria to guarantee the global stability for the nonlinear neutral systems with time-varying delays in the specified switching surface, whose condition is formulated as linear matrix inequality. The synthesized sliding mode controller guarantees the reachability of the specified sliding surface. Finally, a numerical simulation validates the effectiveness and feasibility of the proposed technique.

  5. Time dependence of vocal tract modes during production of vowels and vowel sequences.

    Science.gov (United States)

    Story, Brad H

    2007-06-01

    Vocal tract shaping patterns based on articulatory fleshpoint data from four speakers in the University of Wisconsin x-ray microbeam (XRMB) database [J. Westbury, UW-Madison, (1994)] were determined with a principal component analysis (PCA). Midsagittal cross-distance functions representative of approximately the front 6 cm of the oral cavity for each of 11 vowels and vowel-vowel (VV) sequences were obtained from the pellet positions and the hard palate profile for the four speakers. A PCA was independently performed on each speaker's set of cross-distance functions representing static vowels only, and again with time-dependent cross-distance functions representing vowels and VV sequences. In all cases, results indicated that the first two orthogonal components (referred to as modes) accounted for more than 97% of the variance in each speaker's set of cross-distance functions. In addition, the shape of each mode was shown to be similar across the speakers suggesting that the modes represent common patterns of vocal tract deformation. Plots of the resulting time-dependent coefficient records showed that the four speakers activated each mode similarly during production of the vowel sequences. Finally, a procedure was described for using the time-dependent mode coefficients obtained from the XRMB data as input for an area function model of the vocal tract.

  6. A Novel Approach to Sliding Mode Control of Time-Delay Systems

    Directory of Open Access Journals (Sweden)

    Hongwei Xia

    2013-01-01

    Full Text Available This paper is concerned with the sliding mode control for a class of linear systems with time-varying delays. By utilizing a novel Lyapunov-Krasovskii functional and combining it with the delay fractioning approach as well as the free-weighting matrix technology, a sufficient condition is established such that the resulting sliding mode dynamics is asymptotically stable. Then, a sliding mode controller for reaching motion is synthesized to guarantee that the trajectories of the resulting closed-loop system can be driven onto a prescribed sliding surface and maintained there for all subsequent time. A numerical example is provided to illustrate the effectiveness of the proposed design approach.

  7. Analysis of strange-mode instability with time-dependent convection in hot massive stars

    CERN Document Server

    Sonoi, Takafumi

    2013-01-01

    We carry out nonadiabatic analysis of strange-modes in hot massive stars with time-dependent convection (TDC) for the first time. Although convective luminosity in envelopes of hot massive stars is not as dominative as in stars near the red edge of the classical Cepheid instability strip in the Hertzsprung-Russell (H-R) diagram, we have found that the strange-mode instability can be affected by the treatment of convection. However, existence of the instability around and over the Humphreys-Davidson (H-D) limit is independent of the treatment. This implies that the strange-mode instability could be responsible for the lack of observed stars over the H-D limit regardless of uncertainties on convection theories.

  8. Quantum effects of massive modes in a cosmological quantum space-time

    CERN Document Server

    Tavakoli, Yaser

    2015-01-01

    The quantum theory of a massive, minimally coupled scalar field on an isotropic cosmological quantum space-time is revisited. The interplay between the quantum background and the massive modes of the field, when disregarding their back-reaction effects, gives rise to a theory of quantum field on an effective, dressed space-time whose isotropy may be broken in the direction of the field propagation. On the resulting dressed geometry, evolution of the massive modes, by analyzing the solutions to the corresponding Klein-Gordon equation, is investigated. In particular, by computing the leading order contributions in adiabatic series, an approximate solution for the mode function is obtained. By using the adiabatic regularization, to the fourth order in expansion series, the renormalization of the stress-energy and Hamiltonian of the quantized field is studied. The problem of particle production is studied here in the light of the classical theory of wave propagation on the effective anisotropic background. To the...

  9. Mode of Delivery according to Leisure Time Physical Activity before and during Pregnancy

    DEFF Research Database (Denmark)

    Nielsen, Emilie Nor; Andersen, Per Kragh; Hegaard, Hanne Kristine

    2017-01-01

    Objectives: To examine the association between maternal leisure time physical activity and mode of delivery. Study Design: Population-based multicentre cohort. From the Danish Dystocia Study, we included 2,435 nulliparous women, who delivered a singleton infant in cephalic presentation at term...... after spontaneous onset of labor in 2004-2005. We analysed mode of delivery according to self-reported physical activity at four stages, that is, the year before pregnancy and during first, second, and third trimester, in logistic regression models. Further, we combined physical activity measures at all...... with statistically significant trends at all four time stages except the third trimester. This tendency was confirmed in the proportional odds model showing 28% higher odds of a more complicated mode of delivery among women with a low activity level compared to moderately active women. Conclusions: We found...

  10. Adaptive uniform finite-/fixed-time convergent second-order sliding-mode control

    Science.gov (United States)

    Basin, Michael; Bharath Panathula, Chandrasekhara; Shtessel, Yuri

    2016-09-01

    This paper presents an adaptive gain algorithm for second-order sliding-mode control (2-SMC), specifically a super-twisting (STW)-like controller, with uniform finite/fixed convergence time, that is robust to perturbations with unknown bounds. It is shown that a second-order sliding mode is established as exact finite-time convergence to the origin if the adaptive gain does not have the ability to get reduced and converge to a small vicinity of the origin if the adaptation algorithm does not overestimate the control gain. The estimate of fixed convergence time of the studied adaptive STW-like controller is derived based on the Lyapunov analysis. The efficacy of the proposed adaptive algorithm is illustrated in a tutorial example, where the adaptive STW-like controller with uniform finite/fixed convergence time is compared to the adaptive STW controller with non-uniform finite convergence time.

  11. How Do Mode and Timing of Follow-up Surveys Affect Evaluation Success?

    Science.gov (United States)

    Koundinya, Vikram; Klink, Jenna; Deming, Philip; Meyers, Andrew; Erb, Kevin

    2016-01-01

    This article presents the analysis of evaluation methods used in a well-designed and comprehensive evaluation effort of a significant Extension program. The evaluation data collection methods were analyzed by questionnaire mode and timing of follow-up surveys. Response rates from the short- and long-term follow-ups and different questionnaire…

  12. Real time MHD mode control using ECCD in KSTAR: Plan and requirements

    Energy Technology Data Exchange (ETDEWEB)

    Joung, M.; Woo, M. H.; Jeong, J. H.; Hahn, S. H.; Yun, S. W.; Lee, W. R.; Bae, Y. S.; Oh, Y. K.; Kwak, J. G.; Yang, H. L. [National Fusion Research Institute, 52 Eoeun-dong, Yuseong-gu, Daejeon (Korea, Republic of); Namkung, W.; Park, H.; Cho, M. H. [Department of Physics, POSTECH, Hyoja-dong, Nam-gu, Pohang, Gyeongangbuk-do (Korea, Republic of); Kim, M. H.; Kim, K. J.; Na, Y. S. [Department of Nuclear Engineering, Seoul National University, Daehak-dong, Gwanak-gu, Seoul (Korea, Republic of); Hosea, J.; Ellis, R. [Princeton Plasma Physics Laboratory, Princeton (United States)

    2014-02-12

    For a high-performance, advanced tokamak mode in KSTAR, we have been developing a real-time control system of MHD modes such as sawtooth and Neo-classical Tearing Mode (NTM) by ECH/ECCD. The active feedback control loop will be also added to the mirror position and the real-time detection of the mode position. In this year, for the stabilization of NTM that is crucial to plasma performance we have implemented open-loop ECH antenna control system in KSTAR Plasma Control System (PCS) for ECH mirror movement during a single plasma discharge. KSTAR 170 GHz ECH launcher which was designed and fabricated by collaboration with PPPL and POSTECH has a final mirror of a poloidally and toroidally steerable mirror. The poloidal steering motion is only controlled in the real-time NTM control system and its maximum steering speed is 10 degree/sec by DC motor. However, the latency of the mirror control system and the return period of ECH antenna mirror angle are not fast because the existing launcher mirror control system is based on PLC which is connected to the KSTAR machine network through serial to LAN converter. In this paper, we present the design of real time NTM control system, ECH requirements, and the upgrade plan.

  13. Cardiac time intervals by tissue Doppler imaging M-mode echocardiography

    DEFF Research Database (Denmark)

    Biering-Sørensen, Tor

    2016-01-01

    BACKGROUND: The preservation of normal cardiac time intervals is intimately related to normal cardiac physiology and function. In the ailing myocardium, the cardiac time intervals will change during disease progression. As left ventricular (LV) systolic function deteriorates, the time it takes...... of whether the LV is suffering from impaired systolic or diastolic function. A novel method of evaluating the cardiac time intervals has recently evolved. Using tissue Doppler imaging (TDI) M-mode through the mitral valve (MV) to estimate the cardiac time intervals may be an improved method reflecting global...

  14. Populism : polder and prairie: The rapid rise and fall of Pim Fortuyn

    NARCIS (Netherlands)

    Lucardie, Anthonie

    2004-01-01

    DUTCH POLITICS HAS A REPUTATION FOR DULLNESS AND STABILITY. But that was hardly the case in 2002, when Pim Fortuyn entered politics. His party came in second in that year's election, although it had not yet been formally founded and Fortuyn himself had been murdered a few days earlier. Yet it now re

  15. Lymphoma induction by heterocyclic amines in Eu-pim-1 transgenic mice

    DEFF Research Database (Denmark)

    Sørensen, Ilona Kryspin; Kristiansen, E.; Mortensen, Alicja

    1997-01-01

    The usefulness of transgenic E mu-pim-1 mice bearing in their genome the pim-1 oncogene supplemented with an upstream immunoglobulin enhancer and a downstream murine leukaemia virus long terminal repeat, as sensitive test organisms was studied in two short-term carcinogenicity studies. The mice...... were fed standard diet Altromin 1314 supplemented either with 0.03% 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) for 7 months or with 0.03% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for 6 months. PhIP and IQ are heterocyclic amines formed during cooking of meat and fish and are mutagenic...... to bacteria and cultured mammalian cells. PhIP is a potent mouse lymphomagen, while IQ is a liver, lung and forestomach carcinogen in mice. We found that transgenic E mu-pim-1 mice are highly susceptible to PhIP induced lymphomagenesis but do not respond to IQ treatment. PhIP feeding of E mu-pim-1 mice...

  16. Polymer Inclusion Membranes (PIM) for the Recovery of Potassium in the Presence of Competitive Cations

    NARCIS (Netherlands)

    Casadella, Anna; Schaetzle, Olivier; Nijmeijer, Kitty; Loos, Katja

    2016-01-01

    Potassium is an important nutrient used in fertilizers but is not always naturally available We investigated the properties of polymer inclusion membranes (PIM) regarding their selective recovery of K+ over competitive ions typically present in urine (Na+ and NH4+). The greatest flux was observed wh

  17. Multiplexed Single-Mode Wavelength-to-Time Mapping of Multimode Light

    CERN Document Server

    Chandrasekharan, Harikumar K; Gris-Sánchez, Itandehui; Krstajić, Nikola; Walker, Richard; Bridle, Helen L; Dalgarno, Paul A; MacPherson, William N; Henderson, Robert K; Birks, Tim A; Thomson, Robert R

    2016-01-01

    We demonstrate that photonic lanterns based on tapered multicore fibres provide an efficient way to couple multimode states of light to a two-dimensional array of Single-Photon Avalanche Detectors (SPADs), each of which has its own Time-to-Digital Converter (TDC) for Time-Correlated Single-Photon-Counting (TCSPC). Exploiting this capability, we demonstrate multiplexed single-mode wavelength-to-time conversion of multimode states of light using a multicore-fibre photonic lantern with 121 single-mode cores, coupled in a one-to-one fashion to 121 SPADS on a 32 $\\times$ 32 pixel CMOS SPAD array. The application of photonic lanterns for coupling multimode light to SPAD arrays in this manner may find wide-ranging applications in areas such as Raman spectroscopy, coherent LIDAR and quantum optics.

  18. New adaptive quasi-sliding mode control for nonlinear discrete-time systems

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new adaptive quasi-sliding mode control algorithm is developed for a class of nonlinear diecrete-time systems,which is especially useful for nonlinear systems with vaguely known dynamics.This design is model-free,and is based directly on pseudo-partial-derivatives derived on-line from the input and output information of the system using an improved recursive projection type of identification algorithm.The theoretical analysis and simulation results show that the adaptive quasi-sliding mode control system is stable and convergent.

  19. Mode selective damping of electromechanical oscillations in power systems considering time delay uncertainty of input signals

    Energy Technology Data Exchange (ETDEWEB)

    Hashmani, Ashfaque A.; Erlich, Istvan [Duisburg-Essen Univ., Duisburg (Germany). Inst. of Electrical Power Systems

    2011-07-01

    This paper presents the design of an H{sub {infinity}}-based local decentralized power system stabilizer (PSS) controllers, using selected suitable remote signals from the whole system as supplementary inputs, for a separate better damping of specific inter-area modes, considering uncertainty in time delay. The wide area or global signals are taken from suitable remote network locations where the oscillations are well observable. The PSS controller uses only those local and remote input signals in which the assigned single inter-area mode is most observable and is located at a generator which is most effective. (orig.)

  20. Time Domain Dynamic Analysis of 1550nm Monolithic Two Sections Mode Locked MQW Laser

    OpenAIRE

    DUMAN, Çağlar; ÇAKMAK, Bülent

    2015-01-01

    In this study, time domain dynamic model of a mode locked two sections DBR laser was obtained. Sort duration and high power optical pulse generation from a semiconductor laser was examined by using obtained model. For this aim, while one of the laser sections was thought as reverse biased and so acted as a saturable absorber, other section thought as forward biased with a DC current and so acted as a gain section. A semiconductor laser biased this way can produce mode locked pulses by suitabl...

  1. Robust fault detection for discrete-time Markovian jump systems with mode-dependent time-delays

    Institute of Scientific and Technical Information of China (English)

    Hongru WANG; Changhong WANG; Shaoshuai MOU; Huijun GAO

    2007-01-01

    This paper investigates a fault detection problem for a class of discrete-time Markovian jump systems with norm-bounded uncertainties and mode-dependent time-delays. Attention is focused on constructing the residual generator based on the filter of which its parameters matrices are dependent on the system mode, that is, the fault detection filter is a Markovian jump system as well. The design of fault detection filter is reduced to H-infinity filtering problem by using H-infinity control theory, which can guarantee the difference between the residual and the fault (or, more generally weighted fault) as small as possible in the context of enhancing the robustness of residual to modeling errors, control inputs and unknown inputs. Sufficient condition for the existence of the above filters is established by means of linear matrix inequalities, which can be readily solved by using standard numerical software. A numerical example is given to illustrate the feasibility of the proposed method.

  2. The Optimization of Passengers’ Travel Time under Express-Slow Mode Based on Suburban Line

    Directory of Open Access Journals (Sweden)

    Xiaobing Ding

    2016-01-01

    Full Text Available The suburban line connects the suburbs and the city centre; it is of huge advantage to attempt the express-slow mode. The passengers’ average travel time is the key factor to reflect the level of rail transport services, especially under the express-slow mode. So it is important to study the passengers’ average travel time under express-slow, which can get benefit on the optimization of operation scheme. First analyze the main factor that affects passengers’ travel time and then mine the dynamic interactive relationship among the factors. Second, a new passengers’ travel time evolution algorithm is proposed after studying the stop schedule and the proportion of express/slow train, and then membrane computing theory algorithm is introduced to solve the model. Finally, Shanghai Metro Line 22 is set as an example to apply the optimization model to calculate the total passengers’ travel time; the result shows that the total average travel time under the express-slow mode can save 1 minute and 38 seconds; the social influence and value of it are very huge. The proposed calculation model is of great help for the decision of stop schedule and provides theoretical and methodological support to determine the proportion of express/slow trains, improves the service level, and enriches and complements the rail transit operation scheme optimization theory system.

  3. A Discrete-Time Chattering Free Sliding Mode Control with Multirate Sampling Method for Flight Simulator

    Directory of Open Access Journals (Sweden)

    Yunjie Wu

    2013-01-01

    Full Text Available In order to improve the tracking accuracy of flight simulator and expend its frequency response, a multirate-sampling-method-based discrete-time chattering free sliding mode control is developed and imported into the systems. By constructing the multirate sampling sliding mode controller, the flight simulator can perfectly track a given reference signal with an arbitrarily small dynamic tracking error, and the problems caused by a contradiction of reference signal period and control period in traditional design method can be eliminated. It is proved by theoretical analysis that the extremely high dynamic tracking precision can be obtained. Meanwhile, the robustness is guaranteed by sliding mode control even though there are modeling mismatch, external disturbances and measure noise. The validity of the proposed method is confirmed by experiments on flight simulator.

  4. Sliding mode control for multi-agent systems under a time-varying topology

    Science.gov (United States)

    Dong, Lijing; Chai, Senchun; Zhang, Baihai; Kiong Nguang, Sing

    2016-07-01

    This paper addresses the tracking problem of a class of multi-agent systems under uncertain communication environments which has been modelled by a finite number of constant Laplacian matrices together with their corresponding scheduling functions. Sliding mode control method is applied to solve this nonlinear tracking problem under a time-varying topology. The controller of each tracking agent has been designed by using only its own and neighbours' information. Sufficient conditions for the existence of a sliding mode control tracking strategy have been provided by the solvability of linear matrix inequalities. At the end of this work, numerical simulations are employed to demonstrate the effectiveness of the proposed sliding mode control tracking strategy.

  5. Sliding Mode Control for Discrete-Time Systems With Markovian Packet Dropouts.

    Science.gov (United States)

    Song, Heran; Chen, Shih-Chi; Yam, Yeung

    2016-07-09

    This paper presents the design of a sliding mode controller for networked control systems subject to successive Markovian packet dropouts. This paper adopts the Gilbert-Elliott channel model to describe the temporal correlation among packet losses, and proposes an update scheme to select the assumed available states for use in a sliding mode control law. A technique used in the theory of discrete-time Markov jump linear systems is applied to tackle the effect of the packet losses. This involves introducing a couple of Lyapunov functions dependent on the indicator functions of the instantaneous packet loss, and proving that the sliding mode controller is able to drive the system state trajectories into the neighborhood of the designed integral sliding surface in mean-square sense given that the corresponding Lyapunov inequalities are satisfied. The system is guaranteed thereafter to remain inside the neighborhood of the sliding surface. Simulated case studies are presented to illustrate the effectiveness of the control law.

  6. Frequency-shaped and observer-based discrete-time sliding mode control

    CERN Document Server

    Mehta, Axaykumar

    2015-01-01

    It is well established that the sliding mode control strategy provides an effective and robust method of controlling the deterministic system due to its well-known invariance property to a class of bounded disturbance and parameter variations. Advances in microcomputer technologies have made digital control increasingly popular among the researchers worldwide. And that led to the study of discrete-time sliding mode control design and its implementation. This brief presents, a method for multi-rate frequency shaped sliding mode controller design based on switching and non-switching type of reaching law. In this approach, the frequency dependent compensator dynamics are introduced through a frequency-shaped sliding surface by assigning frequency dependent weighing matrices in a linear quadratic regulator (LQR) design procedure. In this way, the undesired high frequency dynamics or certain frequency disturbance can be eliminated. The states are implicitly obtained by measuring the output at a faster rate than th...

  7. Stability Analysis of Strange-Modes in Hot Massive Stars with Time-Dependent Convection

    CERN Document Server

    Sonoi, Takafumi

    2014-01-01

    We carry out a nonadiabatic analysis of strange-modes in hot massive stars with time-dependent convection (TDC). In envelopes of such stars, convective luminosity is not so dominant as that in envelopes of stars in the redder side of the classical instability strip. Around the Fe opacity bump, however, convection non-negligibly contributes to energy transfer. Indeed, instability of modes excited at the Fe bump is likely to be suppressed with TDC compared with the case of adopting the frozen-in convection approximation. But we make sure that unstable strange-modes certainly appear in hot massive stars even by taking into account TDC. We also examine properties of the strange-mode instability, which is related to destabilization of strange-modes without adiabatic counterparts. In this type of instability, the phase lag between density and pressure varies from 0 to $180^{\\circ}$ in an excitation zone unlike the case of the $\\kappa$-mechanism. In addition, we confirm by comparing models with $Z=0$ and $Z=0.02$ th...

  8. Empirical mode decomposition as a time-varying multirate signal processing system

    Science.gov (United States)

    Yang, Yanli

    2016-08-01

    Empirical mode decomposition (EMD) can adaptively split composite signals into narrow subbands termed intrinsic mode functions (IMFs). Although an analytical expression of IMFs extracted by EMD from signals is introduced in Yang et al. (2013) [1], it is only used for the case of extrema spaced uniformly. In this paper, the EMD algorithm is analyzed from digital signal processing perspective for the case of extrema spaced nonuniformly. Firstly, the extrema extraction is represented by a time-varying extrema decimator. The nonuniform extrema extraction is analyzed through modeling the time-varying extrema decimation at a fixed time point as a time-invariant decimation. Secondly, by using the impulse/summation approach, spline interpolation for knots spaced nonuniformly is shown as two basic operations, time-varying interpolation and filtering by a time-varying spline filter. Thirdly, envelopes of signals are written as the output of the time-varying spline filter. An expression of envelopes of signals in both time and frequency domain is presented. The EMD algorithm is then described as a time-varying multirate signal processing system. Finally, an equation to model IMFs is derived by using a matrix formulation in time domain for the general case of extrema spaced nonuniformly.

  9. Timing and Operating Mode Design for Time-Gated Fluorescence Lifetime Imaging Microscopy

    OpenAIRE

    Chao Liu; Xinwei Wang; Yan Zhou; Yuliang Liu

    2013-01-01

    Steady-state fluorence imaging and time-resolved fluorescence imaging are two important areas in fluorescence imaging research. Fluorescence lifetime imaging is an absolute measurement method which is independent of excitation laser intensity, fluorophore concentration, and photobleaching compared to fluorescence intensity imaging techniques. Time-gated fluorescence lifetime imaging microscopy (FLIM) can provide high resolution and high imaging frame during mature FLIM methods. An abstract ti...

  10. APNEA list mode data acquisition and real-time event processing

    Energy Technology Data Exchange (ETDEWEB)

    Hogle, R.A.; Miller, P. [GE Corporate Research & Development Center, Schenectady, NY (United States); Bramblett, R.L. [Lockheed Martin Specialty Components, Largo, FL (United States)

    1997-11-01

    The LMSC Active Passive Neutron Examinations and Assay (APNEA) Data Logger is a VME-based data acquisition system using commercial-off-the-shelf hardware with the application-specific software. It receives TTL inputs from eighty-eight {sup 3}He detector tubes and eight timing signals. Two data sets are generated concurrently for each acquisition session: (1) List Mode recording of all detector and timing signals, timestamped to 3 microsecond resolution; (2) Event Accumulations generated in real-time by counting events into short (tens of microseconds) and long (seconds) time bins following repetitive triggers. List Mode data sets can be post-processed to: (1) determine the optimum time bins for TRU assay of waste drums, (2) analyze a given data set in several ways to match different assay requirements and conditions and (3) confirm assay results by examining details of the raw data. Data Logger events are processed and timestamped by an array of 15 TMS320C40 DSPs and delivered to an embedded controller (PowerPC604) for interim disk storage. Three acquisition modes, corresponding to different trigger sources are provided. A standard network interface to a remote host system (Windows NT or SunOS) provides for system control, status, and transfer of previously acquired data. 6 figs.

  11. Joint multi-mode dispersion extraction in Fourier and space time domains

    CERN Document Server

    Bose, Sandip; Valero, Henri-Pierre

    2013-01-01

    In this paper we present a novel broadband approach for the extraction of dispersion curves of multiple time frequency overlapped dispersive modes such as in borehole acoustic data. The new approach works jointly in the Fourier and space time domains and, in contrast to existing space time approaches that mainly work for time frequency separated signals, efficiently handles multiple signals with significant time frequency overlap. The proposed method begins by exploiting the slowness (phase and group) and time location estimates based on frequency-wavenumber (f-k) domain sparsity penalized broadband dispersion extraction method as presented in \\cite{AeronTSP2011}. In this context we first present a Cramer Rao Bound (CRB) analysis for slowness estimation in the (f-k) domain and show that for the f-k domain broadband processing, group slowness estimates have more variance than the phase slowness estimates and time location estimates. In order to improve the group slowness estimates we exploit the time compactne...

  12. Relationship of edge localized mode burst times with divertor flux loop signal phase in JET

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, S. C., E-mail: S.C.Chapman@warwick.ac.uk [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry (United Kingdom); Max Planck Institute for the Physics of Complex Systems, Dresden (Germany); Dendy, R. O. [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry (United Kingdom); Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom); JET-EFDA, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom); Todd, T. N.; Webster, A. J.; Morris, J. [Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom); JET-EFDA, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom); Watkins, N. W. [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry (United Kingdom); Max Planck Institute for the Physics of Complex Systems, Dresden (Germany); Centre for the Analysis of Time Series, London School of Economics, London (United Kingdom); Department of Engineering and Innovation, Open University, Milton Keynes (United Kingdom); Calderon, F. A. [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry (United Kingdom); JET-EFDA, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom)

    2014-06-15

    A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM.

  13. Application analysis of empirical mode decomposition and phase space reconstruction in dam time-varying characteristic

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In view of some courses of the time-varying characteristics processing in the analysis of dam deformation,the paper proposes a new method to analyze the dam time-varying characteristic based on the empirical mode decomposition and phase space reconstruction theory.First of all,to reduce the influences on the traditional statistical model from human factors and assure the analysis accuracy,response variables of the time-varying characteristic are obtained by the way of the empirical mode decomposition;and then,a phase plane of those variables is reconstructed to investigate their processing rules.These methods have already been applied to an actual project and the results showed that data interpretation with the assists of empirical mode decomposition and phase space reconstruction is effective in analyzing the perturbations of response variables,explicit in reflecting the entire development process,and valid for obtaining the evolution rules of the time-varying characteristic.This methodology is a powerful technical support for people to further master the rules of dam operation.

  14. Using dynamic mode decomposition for real-time background/foreground separation in video

    Energy Technology Data Exchange (ETDEWEB)

    Kutz, Jose Nathan; Grosek, Jacob; Brunton, Steven; Fu, Xing; Pendergrass, Seth

    2017-06-06

    The technique of dynamic mode decomposition (DMD) is disclosed herein for the purpose of robustly separating video frames into background (low-rank) and foreground (sparse) components in real-time. Foreground/background separation is achieved at the computational cost of just one singular value decomposition (SVD) and one linear equation solve, thus producing results orders of magnitude faster than robust principal component analysis (RPCA). Additional techniques, including techniques for analyzing the video for multi-resolution time-scale components, and techniques for reusing computations to allow processing of streaming video in real time, are also described herein.

  15. Dynamic optimum dead time in piezoelectric transformer-based switch-mode power supplies

    DEFF Research Database (Denmark)

    Ekhtiari, Marzieh; Andersen, Thomas; Andersen, Michael A. E.;

    2016-01-01

    Soft switching is required to attain high efficiency in high-frequency power converters. Piezoelectric transformerbased converters can benefit from soft switching in terms of significantly diminished switching losses and stresses. Adequate dead time is needed in order to deliver sufficient energy...... to charge and discharge the input capacitance of piezoelectric transformers in order to achieve zero-voltage switching. This paper proposes a method for detecting the optimum dead time in piezoelectric transformer-based switch-mode power supplies. The provision of sufficient dead time in every cycle...

  16. Time-Delayed Feedback Control in a Single-Mode Laser System

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The effects of time-delayed feedback control in a single-mode laser system is investigated. Using the small time delay approximation, the analytic expression of the stationary probability distribution function of the laser field is obtaincd. The mean, normalized variance and skewness of the steady-state laser intensity are calculated. It is found that the time-delayed feedback control can suppress the intensity fluctuation of the laser system. The numerical simulations are in good agreement with the approximate analytic results.

  17. Continuous-variable quantum computing in optical time-frequency modes using quantum memories.

    Science.gov (United States)

    Humphreys, Peter C; Kolthammer, W Steven; Nunn, Joshua; Barbieri, Marco; Datta, Animesh; Walmsley, Ian A

    2014-09-26

    We develop a scheme for time-frequency encoded continuous-variable cluster-state quantum computing using quantum memories. In particular, we propose a method to produce, manipulate, and measure two-dimensional cluster states in a single spatial mode by exploiting the intrinsic time-frequency selectivity of Raman quantum memories. Time-frequency encoding enables the scheme to be extremely compact, requiring a number of memories that are a linear function of only the number of different frequencies in which the computational state is encoded, independent of its temporal duration. We therefore show that quantum memories can be a powerful component for scalable photonic quantum information processing architectures.

  18. Incubation time of heterogeneous growth of islands in the mode of incomplete condensation

    Science.gov (United States)

    Dubrovskii, V. G.

    2016-11-01

    The incubation time necessary for the growth of surface islands on heterogeneous nucleation centers to begin has been theoretically analyzed depending on the material gas flow and surface temperature. It is shown that, under heterogeneous growth in the mode of incomplete condensation, the incubation time increases with temperature according to the Arrhenius law and is inversely proportional to the flow, irrespective of the mechanism of diffusion transport to islands. The results obtained have been qualitatively compared with the experimental data on the incubation time for three-dimensional GaN islands arising in the initial stage of self-induced growth of GaN nanowires.

  19. High-Accuracy Tracking Control of Robot Manipulators Using Time Delay Estimation and Terminal Sliding Mode

    Directory of Open Access Journals (Sweden)

    Maolin Jin

    2011-09-01

    Full Text Available A time delay estimation based general framework for trajectory tracking control of robot manipulators is presented. The controller consists of three elements: a time‐delay‐estimation element that cancels continuous nonlinearities of robot dynamics, an injecting element that endows desired error dynamics, and a correcting element that suppresses residual time delay estimation error caused by discontinuous nonlinearities. Terminal sliding mode is used for the correcting element to pursue fast convergence of the time delay estimation error. Implementation of proposed control is easy because calculation of robot dynamics including friction is not required. Experimental results verify high‐accuracy trajectory tracking of industrial robot manipulators.

  20. Dead time effects in turbulence spectra measured by burst-mode LDA

    Science.gov (United States)

    Velte, Clara; Buchhave, Preben; George, William

    2014-11-01

    Dead time effects in laser Doppler measurements have not so far been considered a major problem. We show how dead time occurs in burst-mode laser Doppler anemometry (LDA) when using a so-called burst-mode LDA processor and describe their effects on the measured power spectra. We show how dead time effects may be caused by more than one seed particle being present in the measurement volume at the same time and explain analytically how dead time causes a reduction in the power in the spectrum at low frequencies and an oscillation in the spectrum at the high frequency end. We also present a realistic model for the data sampled from a processor with dead time and use this model to generate turbulence velocity data in a computer. Finally we compare the spectrum computed from realistic values of dead time and sample rate in the computer generated data and compare this spectrum to a measured spectrum in a free turbulent jet with similar parameters. The excellent agreement between the features of these spectra show that our model and explanation of the dead time effect is a valid one.

  1. Finite-time control for nonlinear spacecraft attitude based on terminal sliding mode technique.

    Science.gov (United States)

    Song, Zhankui; Li, Hongxing; Sun, Kaibiao

    2014-01-01

    In this paper, a fast terminal sliding mode control (FTSMC) scheme with double closed loops is proposed for the spacecraft attitude control. The FTSMC laws are included both in an inner control loop and an outer control loop. Firstly, a fast terminal sliding surface (FTSS) is constructed, which can drive the inner loop tracking-error and the outer loop tracking-error on the FTSS to converge to zero in finite time. Secondly, FTSMC strategy is designed by using Lyaponov's method for ensuring the occurrence of the sliding motion in finite time, which can hold the character of fast transient response and improve the tracking accuracy. It is proved that FTSMC can guarantee the convergence of tracking-error in both approaching and sliding mode surface. Finally, simulation results demonstrate the effectiveness of the proposed control scheme.

  2. Time-varying Sliding Mode Controls in Rigid Spacecraft Attitude Tracking

    Institute of Scientific and Technical Information of China (English)

    Jin Yongqiang; Liu Xiangdong; Qiu Wei; Hou Chaozhen

    2008-01-01

    To solve the problem of attitude tracking of a rigid spacecraft with an either known or measurable desired attitude trajectory, three types of time-varying sliding mode controls are introduced under consideration of control input constraints. The sliding surfaces of the three types initially pass arbitrary initial values of the system, and then shift or rotate to reach predetermined ones. This way, the system trajectories are always on the sliding surfaces, and the system work is guaranteed to have robustness against paramour uncertainty and external disturbances all the time. The controller parameters are optimized by means of genetic algorithm to minimize the index consisting of the weighted index of squared error (ISE) of the system and the weighted penalty term of violation of control input constraint. The stability is verified with Lyapunov method. Compared with the conventional sliding mode control, simulation results show the proposed algorithm having better robustness against inertia matrix uncertainty and external disturbance torques.

  3. A hybrid mode choice model to account for the dynamic effect of inertia over time

    DEFF Research Database (Denmark)

    Cherchi, Elisabetta; Börjesson, Maria; Bierlaire, Michel

    gathered over a continuous period of time, six weeks, to study both inertia and the influence of habits. Tendency to stick with the same alternative is measured through lagged variables that link the current choice with the previous trip made with the same purpose, mode and time of day. However, the lagged...... effect of the previous trips is not constant but it depends on the individual propensity to undertake habitual trips which is captured by the individual specific latent variable. And the frequency of the trips in the previous week is used as an indicator of the habitual behavior. The model estimation...... confirms that the tendency to stick with the same alternative varies not only among modes but also across individuals as a function of the individual propensity to undertake habitual behavior....

  4. Fast Intrinsic Mode Decomposition of Time Series Data with Sawtooth Transform

    CERN Document Server

    Lu, Louis Yu

    2007-01-01

    A new method is introduced in this paper to find the intrinsic mode function (IMF) components of time series data. This method is faster and more predictable than the Empirical Mode Decomposition (EMD) method devised by the author of Hilbert Huang Transform (HHT). The approach is to transforms the original data function into a piecewise linear sawtooth function (or triangle wave function), then directly constructs the upper envelope by connecting the maxima and construct lower envelope by connecting minima with straight line segments in the sawtooth space, the IMF is calculated as the difference between the sawtooth function and the mean of the upper and lower envelopes. The results found in the sawtooth space are reversely transformed into the original data space as the required IMF and envelopes mean. This decomposition method process the data in one pass to obtain a unique IMF component without the time consuming repetitive sifting process of EMD method. An alternative decomposition method with sawtooth fu...

  5. Late-time quadratic growth in single-mode Rayleigh-Taylor instability.

    Science.gov (United States)

    Wei, Tie; Livescu, Daniel

    2012-10-01

    The growth of the two-dimensional single-mode Rayleigh-Taylor instability (RTI) at low Atwood number (A=0.04) is investigated using Direct Numerical Simulations. The main result of the paper is that, at long times and sufficiently high Reynolds numbers, the bubble acceleration becomes stationary, indicating mean quadratic growth. This is contrary to the general belief that single-mode Rayleigh-Taylor instability reaches a constant bubble velocity at long times. At unity Schmidt number, the development of the instability is strongly influenced by the perturbation Reynolds number, defined as Rep≡λsqrt[Agλ/(1+A)]/ν. Thus, the instability undergoes different growth stages at low and high Rep. A new stage, chaotic development, was found at sufficiently high Rep values, after the reacceleration stage. During the chaotic stage, the instability experiences seemingly random acceleration and deceleration phases, as a result of complex vortical motions, with strong dependence on the initial perturbation shape (i.e., wavelength, amplitude, and diffusion thickness). Nevertheless, our results show that the mean acceleration of the bubble front becomes constant at late times, with little influence from the initial shape of the interface. As Rep is lowered to small values, the later instability stages, chaotic development, reacceleration, potential flow growth, and even the exponential growth described by linear stability theory, are subsequently no longer reached. Therefore, the results suggest a minimum Reynolds number and a minimum development time necessary to achieve all stages of single-mode RTI development, requirements which were not satisfied in the previous studies of single-mode RTI.

  6. Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.

    Science.gov (United States)

    Casuscelli, Francesco; Ardini, Elena; Avanzi, Nilla; Casale, Elena; Cervi, Giovanni; D'Anello, Matteo; Donati, Daniele; Faiardi, Daniela; Ferguson, Ronald D; Fogliatto, Gianpaolo; Galvani, Arturo; Marsiglio, Aurelio; Mirizzi, Danilo G; Montemartini, Marisa; Orrenius, Christian; Papeo, Gianluca; Piutti, Claudia; Salom, Barbara; Felder, Eduard R

    2013-12-01

    A novel series of PIM inhibitors was derived from a combined effort in natural product-inspired library generation and screening. The novel pyrrolo[1,2-a]pyrazinones initial hits are inhibitors of PIM isoforms with IC50 values in the low micromolar range. The application of a rational optimization strategy, guided by the determination of the crystal structure of the complex in the kinase domain of PIM1 with compound 1, led to the discovery of compound 15a, which is a potent PIM kinases inhibitor exhibiting excellent selectivity against a large panel of kinases, representative of each family. The synthesis, structure-activity relationship studies, and pharmacokinetic data of compounds from this inhibitor class are presented herein. Furthermore, the cellular activities including inhibition of cell growth and modulation of downstream targets are also described.

  7. CMB B-modes, spinorial space-time and Pre-Big Bang (II)

    CERN Document Server

    Gonzalez-Mestres, Luis

    2014-01-01

    The BICEP2 collaboration reported recently a B-mode polarization of the cosmic microwave background (CMB) radiation inconsistent with the null hypothesis at a significance of > 5 {\\sigma}. This result has been often interpreted as a signature of primordial gravitational waves from cosmic inflation, even if actually polarized dust emission may be at the origin of such a signal. Even assuming that part of this CMB B-mode polarization really corresponds to the early Universe dynamics, its interpretation in terms of inflation and primordial gravitational waves is not the only possible one. Alternative cosmologies such as pre-Big Bang patterns and the spinorial space-time (SST) we introduced in 1996-97 can naturally account for such CMB B-modes. In particular, the SST automatically generates a privileged space direction (PSD) whose existence may have been confirmed by Planck data. If such a PSD exists, it seems normal to infer that vector perturbations have been present in the early Universe leading to CMB B-modes...

  8. Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode.

    Science.gov (United States)

    Sorokin, Jordan M; Davidson, Thomas J; Frechette, Eric; Abramian, Armen M; Deisseroth, Karl; Huguenard, John R; Paz, Jeanne T

    2017-01-04

    Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic spiking. Studies in brain slices have led to a model in which rhythmic synchronized spiking (phasic firing) in a population of relay neurons leads to hyper-synchronous oscillatory cortico-thalamo-cortical rhythms that result in absence seizures. This model suggests that blocking thalamocortical phasic firing would treat absence seizures. However, recent in vivo studies in anesthetized animals have questioned this simple model. Here we resolve this issue by developing a real-time, mode-switching approach to drive thalamocortical neurons into or out of a phasic firing mode in two freely behaving genetic rodent models of absence epilepsy. Toggling between phasic and tonic firing in thalamocortical neurons launched and aborted absence seizures, respectively. Thus, a synchronous thalamocortical phasic firing state is required for absence seizures, and switching to tonic firing rapidly halts absences. This approach should be useful for modulating other networks that have mode-dependent behaviors.

  9. Sensitivity estimation in time-of-flight list-mode positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Herraiz, J. L. [Madrid-MIT M+Visión Consortium, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 and Grupo de Física Nuclear, Departamento de Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid, CEI Moncloa, Madrid 28040 (Spain); Sitek, A., E-mail: sarkadiu@gmail.com [Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 (United States)

    2015-11-15

    Purpose: An accurate quantification of the images in positron emission tomography (PET) requires knowing the actual sensitivity at each voxel, which represents the probability that a positron emitted in that voxel is finally detected as a coincidence of two gamma rays in a pair of detectors in the PET scanner. This sensitivity depends on the characteristics of the acquisition, as it is affected by the attenuation of the annihilation gamma rays in the body, and possible variations of the sensitivity of the scanner detectors. In this work, the authors propose a new approach to handle time-of-flight (TOF) list-mode PET data, which allows performing either or both, a self-attenuation correction, and self-normalization correction based on emission data only. Methods: The authors derive the theory using a fully Bayesian statistical model of complete data. The authors perform an initial evaluation of algorithms derived from that theory and proposed in this work using numerical 2D list-mode simulations with different TOF resolutions and total number of detected coincidences. Effects of randoms and scatter are not simulated. Results: The authors found that proposed algorithms successfully correct for unknown attenuation and scanner normalization for simulated 2D list-mode TOF-PET data. Conclusions: A new method is presented that can be used for corrections for attenuation and normalization (sensitivity) using TOF list-mode data.

  10. Finite Time Fault Tolerant Control for Robot Manipulators Using Time Delay Estimation and Continuous Nonsingular Fast Terminal Sliding Mode Control.

    Science.gov (United States)

    Van, Mien; Ge, Shuzhi Sam; Ren, Hongliang

    2016-04-28

    In this paper, a novel finite time fault tolerant control (FTC) is proposed for uncertain robot manipulators with actuator faults. First, a finite time passive FTC (PFTC) based on a robust nonsingular fast terminal sliding mode control (NFTSMC) is investigated. Be analyzed for addressing the disadvantages of the PFTC, an AFTC are then investigated by combining NFTSMC with a simple fault diagnosis scheme. In this scheme, an online fault estimation algorithm based on time delay estimation (TDE) is proposed to approximate actuator faults. The estimated fault information is used to detect, isolate, and accommodate the effect of the faults in the system. Then, a robust AFTC law is established by combining the obtained fault information and a robust NFTSMC. Finally, a high-order sliding mode (HOSM) control based on super-twisting algorithm is employed to eliminate the chattering. In comparison to the PFTC and other state-of-the-art approaches, the proposed AFTC scheme possess several advantages such as high precision, strong robustness, no singularity, less chattering, and fast finite-time convergence due to the combined NFTSMC and HOSM control, and requires no prior knowledge of the fault due to TDE-based fault estimation. Finally, simulation results are obtained to verify the effectiveness of the proposed strategy.

  11. Adaptive backstepping finite-time sliding mode control of spacecraft attitude tracking

    Institute of Scientific and Technical Information of China (English)

    Chutiphon Pukdeboon

    2015-01-01

    This paper investigates the finite-time attitude tracking problem for rigid spacecraft. Two backstepping finite-time slid-ing mode control laws are proposed to solve this problem in the presence of inertia uncertainties and external disturbances. The first control scheme is developed by combining sliding mode con-trol with a backstepping technique to achieve fast and accurate tracking responses. To obtain higher tracking precision and relax the requirement of the upper bounds on the uncertainties, a se-cond control law is also designed by combining the second or-der sliding mode control and an adaptive backstepping technique. This control law provides complete compensation of uncertainty and disturbances. Although it assumes that the uncertainty and disturbances are bounded, the proposed control law does not require information about the bounds on the uncertainties and disturbances. Finite-time convergence of attitude tracking errors and the stability of the closed-loop system are ensured by the Lya-punov approach. Numerical simulations on attitude tracking control of spacecraft are provided to demonstrate the performance of the proposed control ers.

  12. The Mechanism of Action of Unique Small Molecules that Inhibit the Pim Protein Kinase Blocking Prostate Cancer Cell Growth

    Science.gov (United States)

    2010-05-01

    Cdh1(DH01) antibody was from Abcam. Anti-Lamin B antibody was from Calbiochem. Roscovitine , and reagents for the in vitro ubiquitination assay were...transfected with Pim-1 and Skp2, metabolically labeled with orthophosphate, and then treated with kinase inhibitors such as roscovitine ( pan-CDK...inhibitor), wortmannin (PI3K inhibitor), and SMI- 4a (Pim-1 inhbitor). Treatment with roscovitine and wortmannin reduced Skp2 phosphorylation in

  13. THz time scale structural rearrangements and binding modes in lysozyme-ligand interactions.

    Science.gov (United States)

    Woods, K N

    2014-03-01

    Predicting the conformational changes in proteins that are relevant for substrate binding is an ongoing challenge in the aim of elucidating the functional states of proteins. The motions that are induced by protein-ligand interactions are governed by the protein global modes. Our measurements indicate that the detected changes in the global backbone motion of the enzyme upon binding reflect a shift from the large-scale collective dominant mode in the unbound state towards a functional twisting deformation that assists in closing the binding cleft. Correlated motion in lysozyme has been implicated in enzyme function in previous studies, but detailed characterization of the internal fluctuations that enable the protein to explore the ensemble of conformations that ultimately foster large-scale conformational change is yet unknown. For this reason, we use THz spectroscopy to investigate the picosecond time scale binding modes and collective structural rearrangements that take place in hen egg white lysozyme (HEWL) when bound by the inhibitor (NAG)3. These protein thermal motions correspond to fluctuations that have a role in both selecting and sampling from the available protein intrinsic conformations that communicate function. Hence, investigation of these fast, collective modes may provide knowledge about the mechanism leading to the preferred binding process in HEWL-(NAG)3. Specifically, in this work we find that the picosecond time scale hydrogen-bonding rearrangements taking place in the protein hydration shell with binding modify the packing density within the hydrophobic core on a local level. These localized, intramolecular contact variations within the protein core appear to facilitate the large cooperative movements within the interfacial region separating the α- and β- domain that mediate binding. The THz time-scale fluctuations identified in the protein-ligand system may also reveal a molecular mechanism for substrate recognition.

  14. Microwave signal extraction from femtosecond mode-locked lasers with attosecond relative timing drift.

    Science.gov (United States)

    Kim, Jungwon; Kärtner, Franz X

    2010-06-15

    We present a feedback-control method for suppression of excess phase noise in the optical-to-electronic conversion process involved in the extraction of microwave signals from femtosecond mode-locked lasers. A delay-locked loop based on drift-free phase detection with a differentially biased Sagnac loop is employed to eliminate low-frequency (e.g., locked laser with a relative rms timing jitter of 2.4 fs (integrated from 1 mHz to 1 MHz) and a relative rms timing drift of 0.84 fs (integrated over 8 h with 1 Hz bandwidth) between the optical pulse train and the extracted microwave signal.

  15. Quantum entanglement of fermions-antifermions pair creation modes in noncommutative Bianchi I space-time

    Science.gov (United States)

    Ghiti, M. F.; Mebarki, N.; Aissaoui, H.

    2015-08-01

    The noncommutative Bianchi I curved space-time vierbeins and spin connections are derived. Moreover, the corresponding noncommutative Dirac equation as well as its solutions are presented. As an application within the quantum field theory approach using Bogoliubov transformations, the von Neumann fermion-antifermion pair creation quantum entanglement entropy is studied. It is shown that its behavior is strongly dependent on the value of the noncommutativity θ parameter, k⊥-modes frequencies and the structure of the curved space-time. Various discussions of the obtained features are presented.

  16. Exciting Reflectionless Unidirectional Edge Modes in a Photonic Topological Insulator Without Breaking Time-Reversal Symmetry

    CERN Document Server

    Xiao, Bo; Yu, Yang; Ma, Tzuhsuan; Shvets, Gennady; Anlage, Steven M

    2016-01-01

    Photonic topological insulators are an interesting class of materials whose photonic band structure can have a bandgap in the bulk while supporting topologically protected unidirectional edge modes. Recent studies on bianisotropic metamaterials that emulate the electronic quantum spin Hall effect using its electromagnetic analog are examples of such systems with relatively simple and elegant design. In this paper, we present a novel rotating magnetic dipole antenna, composed of two perpendicularly oriented helical coils, that can efficiently excite the unidirectional topologically protected surface waves in the bianisotropic metawaveguide (BMW) structure recently realized by Ma, et al., despite the fact that the BMW does not break time-reversal invariance. In addition to achieving high directivity, the antenna can be tuned continuously to excite reflectionless edge modes to the two opposite directions with various amplitude ratios. We demonstrate its performance through experiment and compare to simulation re...

  17. Extending compile-time reverse mode and exploiting partial separability in ADIFOR

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, C.H.; El-Khadiri, M.

    1992-10-01

    The numerical methods employed in the solution of many scientific computing problems require the computation of the gradient of a function f: R[sup n] [yields] R. ADIFOR is a source translator that, given a collection of subroutines to compute f, generates Fortran 77 code for computing the derivative of this function. Using the so-called torsion problem from the MINPACK-2 test collection as an example, this paper explores two issues in automatic differentiation: the efficient computation of derivatives for partial separable functions and the use of the compile-time reverse mode for the generation of derivatives. We show that orders of magnitudes of improvement are possible when exploiting partial separability and maximizing use of the reverse mode.

  18. HiPIMS: a New Generation of Film Deposition Techniques for SRF Applications

    Energy Technology Data Exchange (ETDEWEB)

    Valente-Feliciano, Anne-Marie [JLAB

    2013-09-01

    Over the years, Nb/Cu technology, despite its shortcomings due to the commonly used magnetron sputtering, has positioned itself as an alternative route for the future of accelerator superconducting structures. Avenues for the production of thin films tailored for Superconducting RF (SRF) applications are showing promise with recent developments in ionized PVD coating techniques, i.e. vacuum deposition techniques using energetic ions. Among these techniques, High power impulse magnetron sputtering (HiPIMS) is a promising emerging technique which combines magnetron sputtering with a pulsed power approach. This contribution describes the benefits of energetic condensation for SRF films and the characteristics of the HiPIMS technology. It describes the on-going efforts pursued in different institutions to exploit the potential of this technology to produce bulk-like Nb films and go beyond Nb performance with the development of film systems, based on other superconducting materials and multilayer structures.

  19. Analysis and evaluation of effects of processing steps on dimensional tolerance of PIM parts

    Institute of Scientific and Technical Information of China (English)

    LI Yi-min; LOU Jia; YUE Jian-ling

    2005-01-01

    The factors affecting the dimensional tolerance of powder injection molding (PIM), such as the selection of the powder and binder, the feedstock homogeneity, the feedstock thermal properties, the feedstock rheologic behavior, the debinding schedule and atmosphere and sintering temperature gradient were discussed. An attempt was made to develop a model to estimate the influence of important variables. The results show that a better understanding of these factors can provide some useful theoretical instructions for large scale production.

  20. A hybrid mode choice model to account for the dynamic effect of inertia over time

    DEFF Research Database (Denmark)

    Cherchi, Elisabetta; Börjesson, Maria; Bierlaire, Michel

    gathered over a continuous period of time, six weeks, to study both inertia and the influence of habits. Tendency to stick with the same alternative is measured through lagged variables that link the current choice with the previous trip made with the same purpose, mode and time of day. However, the lagged......The influence of habits, giving rise to inertia effect, in the choice process has been intensely debated in the literature. Typically inertia is accounted for by letting the indirect utility functions of the alternatives of the choice situation at time t depend on the outcome of the choice made...... at a previous point in time. However, according to the psychological literature, inertia is the results of a habit, which is formed in a longer process where many past decisions (not only the immediately previous one) remain in the memory of the consumer and influence behavior. In this study we use panel data...

  1. Turbulent Statistics From Time-Resolved PIV Measurements of a Jet Using Empirical Mode Decomposition

    Science.gov (United States)

    Dahl, Milo D.

    2013-01-01

    Empirical mode decomposition is an adaptive signal processing method that when applied to a broadband signal, such as that generated by turbulence, acts as a set of band-pass filters. This process was applied to data from time-resolved, particle image velocimetry measurements of subsonic jets prior to computing the second-order, two-point, space-time correlations from which turbulent phase velocities and length and time scales could be determined. The application of this method to large sets of simultaneous time histories is new. In this initial study, the results are relevant to acoustic analogy source models for jet noise prediction. The high frequency portion of the results could provide the turbulent values for subgrid scale models for noise that is missed in large-eddy simulations. The results are also used to infer that the cross-correlations between different components of the decomposed signals at two points in space, neglected in this initial study, are important.

  2. Stability analysis of switched cellular neural networks: A mode-dependent average dwell time approach.

    Science.gov (United States)

    Huang, Chuangxia; Cao, Jie; Cao, Jinde

    2016-10-01

    This paper addresses the exponential stability of switched cellular neural networks by using the mode-dependent average dwell time (MDADT) approach. This method is quite different from the traditional average dwell time (ADT) method in permitting each subsystem to have its own average dwell time. Detailed investigations have been carried out for two cases. One is that all subsystems are stable and the other is that stable subsystems coexist with unstable subsystems. By employing Lyapunov functionals, linear matrix inequalities (LMIs), Jessen-type inequality, Wirtinger-based inequality, reciprocally convex approach, we derived some novel and less conservative conditions on exponential stability of the networks. Comparing to ADT, the proposed MDADT show that the minimal dwell time of each subsystem is smaller and the switched system stabilizes faster. The obtained results extend and improve some existing ones. Moreover, the validness and effectiveness of these results are demonstrated through numerical simulations.

  3. The tropical Pacific-Indian Ocean temperature anomaly mode and its effect

    Institute of Scientific and Technical Information of China (English)

    YANG Hui; JIA Xiaolong; LI Chongyin

    2006-01-01

    Temperature anomaly in the Indian Ocean is closely related to that in the Pacific Ocean because of the Walker circulation and the Indonesian throughflow. So only the El Ni(n)o/Southern Oscillation (ENSO) in the Pacific cannot entirely explain the influence of sea surface temperature anomaly (SSTA)on climate variation. The tropical Pacific-Indian Ocean temperature anomaly mode (PIM) is presented based on the comprehensive research on the pattern and feature of SSTA in both Indian Ocean and Pacific Ocean. The features of PIM and ENSO mode and their influences on the climate in China and the rainfall in India are further compared. For proving the observation results, numerical experiments of the global atmospheric general circulation model are conducted. The results of observation and sensitivity experiments show that presenting PIM and studying its influence are very important for short-range climate prediction.

  4. Development of performance indicators for municipal solid waste management (PIMS): A review.

    Science.gov (United States)

    Sanjeevi, V; Shahabudeen, P

    2015-12-01

    The aim of this paper is to review papers on municipal solid waste management (SWM) systems, especially on performance indicators (PIs), and suggest practical methods to manage the same by administrators. Worldwide, about 4 billion metric tons of solid waste (SW) is generated annually; the management of SW across cities is increasingly getting more complex and the funds available for providing service to citizens are shrinking. Analysis of the non-technical research papers shows that focus areas on SW can be grouped into 18 types, one being PIs. Historically, PIs for municipal SWM (PIMS) commenced with the publication of guidelines by various government agencies, starting in 1969. This was followed by a few benchmarking studies, commencing in 1998, by various international institutions. Many published comparative studies also disseminated good practices across the cities. From the 1990s onwards, research work started defining PIMS. These initiatives by various researchers took multiple dimensions and are reviewed in this paper. In almost all studies, the PIMS is measured in terms of investment decisions, public acceptance levels, social participation and environmental needs. The multiple indicators are complex, however, and managers of cities need simple tools to use. To make it simple, five-factor PIs are arrived at, considering simplicity and covering all the factors. A research agenda is outlined for future directions in the areas of cost reduction, citizens' services, citizen involvement and environmental impact.

  5. Remote monitoring of building oscillation modes by means of real-time Mid Infrared Digital Holography

    Science.gov (United States)

    Poggi, Pasquale; Locatelli, Massimiliano; Pugliese, Eugenio; Delle Donne, Dario; Lacanna, Giorgio; Meucci, Riccardo; Ripepe, Maurizio

    2016-04-01

    Non-destructive measurements of deformations are a quite common application of holography but due to the intrinsic limits in the interferometric technique, those are generally confined only to small targets and in controlled environment. Here we present an advanced technique, based on Mid Infrared Digital Holography (MIR DH), which works in outdoor conditions and provides remote and real-time information on the oscillation modes of large engineering structures. Thanks to the long wavelength of the laser radiation, large areas of buildings can be simultaneously mapped with sub-micrometric resolution in terms of their amplitude and frequency oscillation modes providing all the modal parameters vital for all the correct prevention strategies when the functionality and the health status of the structures have to be evaluated. The existing experimental techniques used to evaluate the fundamental modes of a structure are based either on seismometric sensors or on Ground-based Synthetic Aperture Radar (GbSAR). Such devices have both serious drawbacks, which prevent their application at a large scale or in the short term. We here demonstrate that the MIR DH based technique can fully overcome these limitations and has the potential to represent a breakthrough advance in the field of dynamic characterization of large structures.

  6. Time-scaling based sliding mode control for Neuromuscular Electrical Stimulation under uncertain relative degrees.

    Science.gov (United States)

    Oliveira, Tiago Roux; Costa, Luiz Rennó; Catunda, João Marcos Yamasaki; Pino, Alexandre Visintainer; Barbosa, William; Souza, Márcio Nogueira de

    2017-03-28

    This paper addresses the application of the sliding mode approach to control the arm movements by artificial recruitment of muscles using Neuromuscular Electrical Stimulation (NMES). Such a technique allows the activation of motor nerves using surface electrodes. The goal of the proposed control system is to move the upper limbs of subjects through electrical stimulation to achieve a desired elbow angular displacement. Since the human neuro-motor system has individual characteristics, being time-varying, nonlinear and subject to uncertainties, the use of advanced robust control schemes may represent a better solution than classical Proportional-Integral (PI) controllers and model-based approaches, being simpler than more sophisticated strategies using fuzzy logic or neural networks usually applied in this control problem. The objective is the introduction of a new time-scaling base sliding mode control (SMC) strategy for NMES and its experimental evaluation. The main qualitative advantages of the proposed controller via time-scaling procedure are its independence of the knowledge of the plant relative degree and the design/tuning simplicity. The developed sliding mode strategy allows for chattering alleviation due to the impact of the integrator in smoothing the control signal. In addition, no differentiator is applied to construct the sliding surface. The stability analysis of the closed-loop system is also carried out by using singular perturbation methods. Experimental results are conducted with healthy volunteers as well as stroke patients. Quantitative results show a reduction of 45% in terms of root mean square (RMS) error (from 5.9° to [Formula: see text] ) in comparison with PI control scheme, which is similar to that obtained in the literature.

  7. 3D-QSAR and virtual screening studies of thiazolidine-2,4-dione analogs: Validation of experimental inhibitory potencies towards PIM-1 kinase

    Science.gov (United States)

    Asati, Vivek; Bharti, Sanjay Kumar; Budhwani, Ashok Kumar

    2017-04-01

    The proviral insertion site in moloney murine leukemia virus (PIM) is a family of serine/threonine kinase of Ca2+-calmodulin-dependent protein kinase (CAMK) group which is responsible for the activation and regulation of cellular transcription and translation. The three isoforms of PIM kinase (PIM-1, PIM-2 and PIM-3) share high homology and functional idleness are widely expressed and involved in a variety of biological processes including cell survival, proliferation, differentiation and apoptosis. Altered expression of PIM-1 kinase correlated with hematologic malignancies and solid tumors. In the present study, atom-based 3D-QSAR, docking and virtual screening studies have been performed on a series of thiazolidine-2,4-dione derivatives as PIM-1 kinase inhibitors. 3D-QSAR and docking approach has shortlisted the most active thiazolidine-2,4-dione derivatives such as 28, 31, 33 and 35 with the incorporation of more than one structural feature in a single molecule. External validations by various parameters and molecular docking studies at the active site of PIM-1 kinase have proved the reliability of the developed 3D-QSAR model. The generated pharmacophore (AADHR.33) from 3D-QSAR study was used for screening of drug like compounds from ZINC database, where ZINC15056464 and ZINC83292944 showed potential binding affinities at the active site amino acid residues (LYS67, GLU171, ASP128 and ASP186) of PIM-1 kinase (PDB ID: "pdb:4DTK").

  8. GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.

    Science.gov (United States)

    Persico, Marco; Petrella, Lella; Orteca, Nausicaa; Di Dato, Antonio; Mariani, Marisa; Andreoli, Mirko; De Donato, Marta; Scambia, Giovanni; Novellino, Ettore; Ferlini, Cristiano; Fattorusso, Caterina

    2015-02-16

    GBP1 and PIM1 are known to interact with a molar ratio 1:1. GBP1:PIM1 binding initiates a signaling pathway that induces resistance to common chemotherapeutics such as paclitaxel. Since GBP1 is a large GTPase which undergoes conformational changes in a nucleotide-dependent manner, we investigated the effect of GTP/GDP binding on GBP1:PIM1 interaction by using computational and biological studies. It resulted that only GTP decreases the formation of the GBP1:PIM1 complex through an allosteric mechanism, putting the bases for the identification of new compounds potentially able to revert resistance to paclitaxel.

  9. Application of empirical mode decomposition with local linear quantile regression in financial time series forecasting.

    Science.gov (United States)

    Jaber, Abobaker M; Ismail, Mohd Tahir; Altaher, Alsaidi M

    2014-01-01

    This paper mainly forecasts the daily closing price of stock markets. We propose a two-stage technique that combines the empirical mode decomposition (EMD) with nonparametric methods of local linear quantile (LLQ). We use the proposed technique, EMD-LLQ, to forecast two stock index time series. Detailed experiments are implemented for the proposed method, in which EMD-LPQ, EMD, and Holt-Winter methods are compared. The proposed EMD-LPQ model is determined to be superior to the EMD and Holt-Winter methods in predicting the stock closing prices.

  10. Analysis of timing jitter in external-cavity mode-locked semiconductor lasers

    DEFF Research Database (Denmark)

    Mulet, Josep; Mørk, Jesper

    2006-01-01

    processes, self-phase modulation, and spontaneous emission noise. Fluctuations of the mode-locked pulses are characterized from the fully distributed model using direct integration of noise-skirts in the phase-noise spectrum and the soliton perturbations introduced by Haus. We implement the model in order...... to investigate the performance of a MQW buried heterostructure laser. Results from numerical simulations show that the optimum driving conditions for achieving the shortest pulses with minimum timing jitter occur for large reverse bias in the absorber section at an optimum optical bandwidth limited by Gordon...

  11. Application of Empirical Mode Decomposition with Local Linear Quantile Regression in Financial Time Series Forecasting

    Directory of Open Access Journals (Sweden)

    Abobaker M. Jaber

    2014-01-01

    Full Text Available This paper mainly forecasts the daily closing price of stock markets. We propose a two-stage technique that combines the empirical mode decomposition (EMD with nonparametric methods of local linear quantile (LLQ. We use the proposed technique, EMD-LLQ, to forecast two stock index time series. Detailed experiments are implemented for the proposed method, in which EMD-LPQ, EMD, and Holt-Winter methods are compared. The proposed EMD-LPQ model is determined to be superior to the EMD and Holt-Winter methods in predicting the stock closing prices.

  12. New method for nonlinear and nonstationary time series analysis: empirical mode decomposition and Hilbert spectral analysis

    Science.gov (United States)

    Huang, Norden E.

    2000-04-01

    A new method for analyzing nonlinear and nonstationary data has been developed. The key pat of the method is the Empirical Mode Decomposition method with which any complicated data set can be decomposed into a finite and often small number of Intrinsic Mode Functions (IMF). An IMF is define das any function having the same numbers of zero- crossing and extrema, and also having symmetric envelopes defined by the local maxima and minima respectively. The IMF also admits well-behaved Hilbert transform. This decomposition method is adaptive, and therefore, highly efficient. Since the decomposition is based on the local characteristic time scale of het data, it is applicable to nonlinear and nonstationary processes. With the Hilbert transform, the IMF yield instantaneous frequencies as functions of time that give sharp identifications of embedded structures. The final presentation of the result is an energy-frequency-time distribution, designated as the Hilbert Spectrum. Comparisons with Wavelet and window Fourier analysis show the new method offers much better temporal and frequency resolutions.

  13. On the control of bistability in non-contact mode AFM using modulated time delay

    Directory of Open Access Journals (Sweden)

    Kirrou I.

    2014-01-01

    Full Text Available We study the control of bistability in non-contact mode AFM using time delay with modulated feedback gain. We consider that the tip-sample interaction force is described by Lennard-Jones potential and the equation of motion is modeled by single degree of freedom system. Perturbation analysis is performed to obtain the modulation equations of the slow dynamic. The influence of the modulated time delay on the nonlinear characteristic of the frequency response is analyzed and the evolution of the bistability region in the modulated time delay parameter plan is examined. Results show that modulation of the feedback gain can be used to reduce the amplitude of the microcanteliver response and to suppress the bistability regime in large region of the modulated delay parameter space. The analytical predictions are compared to numerical simulations for validation.

  14. Time dependent Bloch mode transmittance in self-assembled random photonic crystal for photonic time delay switching

    Science.gov (United States)

    Bingi, Jayachandra; Nair, Radhika V.; Vijayan, C.

    2017-02-01

    Light propagation and localization in a random structure with a periodic background is an upcoming paradigm for novel photonic applications. This paper demonstrates the phenomenon of time dependent transmittance of evanescent Bloch modes (EBM) in ZnS random photonic crystal (RPC) which forms the basis for photonic delay switching. The RPC is fabricated by colloidal self-assembly with ZnS nanospheres of size 215 nm. An anomalous reciprocity and time dependent transmission at EBM (mid band gap wavelength) are observed in coherent back scattering and transmission studies respectively. These are explained on the basis of restricted propagation of EBMs through random channels in the periodic background and enhanced field storage inside RPC. The channelized propagation of EBMs is evident from decreasing time delay of transmittance at reduced thicknesses. The proportionality between transmission time delay and incident power confirms photon (field) storage within the RPC. The results indicate that structures with systematically engineered EBM channels can work as wavelength selective delay switch and further provide a short time photon storage system under non-absorbing conditions.

  15. 小麦TaPIM1基因的克隆及其转基因烟草的抗病性分析%Cloning of Wheat TaPIM1 Gene and Analysis of Disease Resistance in TaPIM1 Transgenic Tobacco

    Institute of Scientific and Technical Information of China (English)

    周贤尧; 董娜; 刘红霞; 张怀渝; 张增艳

    2010-01-01

    TaPIM1是从小麦中克隆获得的1个病原诱导的小麦MYB基因,编码由323个氨基酸残基组成的蛋白TaPIM1.TaPIM1具有R2R3类MYB转录因子的典型结构,即2个保守的MYB DNA结合域(R2和R3)、核定位位点和酸性激活区.TaPIM1的全长氨基酸序列与已克隆MYB蛋白的一致性仅为43.69%以下,为植物MYB转录因子家族R2R3亚群的一个新成员.小麦纹枯病菌(Rhizoctonia cerealis)、根腐病菌(Bipolaris sorokiniana)侵染可快速诱导抗病小麦中TaPIM1基因的上调表达,说明TaPIM1可能参与小麦对纹枯病菌、根腐病菌的防御反应.将TaPIM1基因构建到由组成型强启动子CaMV35S控制的双子叶转化载体pBI121上,通过农杆菌介导法将其转入烟草W38品系.通过卡那霉素抗性筛选和PCR检测,鉴定出转TaPIM1基因烟草T0代株系M66、M102、M110等12个株系.对转基因烟草T1代株系进行PCR、RT-PCR分析和青枯病菌抗性分析,结果表明,TaPIM1超量表达的转基因烟草株系M66、M102和M110对青枯病菌(Ralstonia solanacearum)的抗性显著高于未转基因烟草对照,TaPIM1正向调控烟草对某些病原菌的防御反应.

  16. On the static loop modes in the marching-on-in-time solution of the time-domain electric field integral equation

    KAUST Repository

    Shi, Yifei

    2014-01-01

    When marching-on-in-time (MOT) method is applied to solve the time-domain electric field integral equation, spurious internal resonant and static loop modes are always observed in the solution. The internal resonant modes have recently been studied by the authors; this letter investigates the static loop modes. Like internal resonant modes, static loop modes, in theory, should not be observed in the MOT solution since they do not satisfy the zero initial conditions; their appearance is attributed to numerical errors. It is discussed in this letter that the dependence of spurious static loop modes on numerical errors is substantially different from that of spurious internal resonant modes. More specifically, when Rao-Wilton-Glisson functions and Lagrange interpolation functions are used as spatial and temporal basis functions, respectively, errors due to space-time discretization have no discernible impact on spurious static loop modes. Numerical experiments indeed support this discussion and demonstrate that the numerical errors due to the approximate solution of the MOT matrix system have dominant impact on spurious static loop modes in the MOT solution. © 2014 IEEE.

  17. Timing accuracy of the Swift X-Ray Telescope in WT mode

    CERN Document Server

    Cusumano, G; Capalbi, M; Perri, M; Beardmore, A P; Burrows, D N; Campana, S; Kennea, J A; Osborne, J P; Sbarufatti, B; Tagliaferri, G

    2012-01-01

    The X-Ray Telescope (XRT) on board Swift was mainly designed to provide detailed position, timing and spectroscopic information on Gamma-Ray Burst (GRB) afterglows. During the mission lifetime the fraction of observing time allocated to other types of source has been steadily increased. In this paper, we report on the results of the in-flight calibration of the timing capabilities of the XRT in Windowed Timing read-out mode. We use observations of the Crab pulsar to evaluate the accuracy of the pulse period determination by comparing the values obtained by the XRT timing analysis with the values derived from radio monitoring. We also check the absolute time reconstruction measuring the phase position of the main peak in the Crab profile and comparing it both with the value reported in literature and with the result that we obtain from a simultaneous Rossi X-Ray Timing Explorer (RXTE) observation. We find that the accuracy in period determination for the Crab pulsar is of the order of a few picoseconds for the...

  18. Design and Modeling of a Flexible Contact-Mode Piezoresistive Detector for Time-Based Acceleration Sensing

    NARCIS (Netherlands)

    Rajaraman, V.; Hau, B.S.; Rocha, L.A.; French, P.J.; Makinwa, K.A.A.

    2010-01-01

    This work reports on the design and modeling of a new flexible contact-mode 1-DOF piezoresistive contact force and impacttime detector used for acceleration sensing in the time domain. The key advantages of the contact-mode detection mechanism are the use of simple readout circuitry, compactness,

  19. Design and Modeling of a Flexible Contact-Mode Piezoresistive Detector for Time-Based Acceleration Sensing

    NARCIS (Netherlands)

    Rajaraman, V.; Hau, B.S.; Rocha, L.A.; French, P.J.; Makinwa, K.A.A.

    2010-01-01

    This work reports on the design and modeling of a new flexible contact-mode 1-DOF piezoresistive contact force and impacttime detector used for acceleration sensing in the time domain. The key advantages of the contact-mode detection mechanism are the use of simple readout circuitry, compactness, go

  20. Northern Hemisphere modes of variability and the timing of spring in western North America

    Science.gov (United States)

    Ault, T.R.; Macalady, A.K.; Pederson, G.T.; Betancourt, J.L.; Schwartz, M.D.

    2011-01-01

    Spatial and temporal patterns of variability in spring onset are identified across western North America using a spring index (SI) model based on weather station minimum and maximum temperatures (Tmin and Tmax, respectively). Principal component analysis shows that two significant and independent patterns explain roughly half of the total variance in the timing of spring onset from 1920 to 2005. However, these patterns of spring onset do not appear to be linear responses to the primary modes of variability in the Northern Hemisphere: the Pacific-North American pattern (PNA) and the northern annular mode (NAM). Instead, over the period when reanalysis data and the spring index model overlap (1950-2005), the patterns of spring onset are local responses to the state of both the PNA and NAM, which together modulate the onset date of spring by 10-20 days on interannual time scales. They do so by controlling the number and intensity of warm days. There is also a region wide trend in spring advancement of about -1.5 days decade-1 from 1950 to 2005. Trends in the NAM and PNA can only explain about one-third (-0.5 day decade-1) of this trend. ?? 2011 American Meteorological Society.

  1. Time to subsequent live birth according to mode of delivery in the first birth.

    Science.gov (United States)

    O'Neill, S M; Khashan, A S; Kenny, L C; Kearney, P M; Mortensen, P B; Greene, R A; Agerbo, E; Uldbjerg, N; Henriksen, T B

    2015-08-01

    To estimate the rate and time to next live birth by mode of delivery. Hospital-based cohort. Aarhus University Hospital (AUH), Denmark. All pregnant women attending AUH were invited to enroll in the Aarhus Birth Cohort (ABC) study between 1989 and 2010 (n = 91,625). Women were followed from their first live birth until the subsequent live birth or until censoring due to study end using Cox regression models. Rate and time to subsequent live birth according to mode of delivery. 46,162 index live births were identified, of which 22,462 (49%) had a subsequent live birth. Women with any type of caesarean had a 6% reduction in the rate of subsequent live birth (HR 0.94, 95% CI 0.89, 0.98), which remained unchanged in the analysis by type (emergency, HR 0.95, 95% CI 0.89, 1.02; elective, HR 0.91, 95% CI 0.85, 0.98) compared with women who had a spontaneous vaginal delivery (SVD). Operative vaginal delivery was associated with an 8% reduction in subsequent live birth rates (HR 0.92, 95% CI 0.86, 0.98) and vaginal delivery complicated by shoulder dystocia with a 19% reduction compared with SVD. Median time to next birth in days was shortest in women with a first caesarean (994 days, 95% CI 973, 1026) and longest in women with a vaginal delivery complicated by shoulder dystocia (1065 days, 95% CI 994, 1191). In women with planned pregnancies, the shortest median time to second birth was in women with breech vaginal deliveries (859 days, 95% CI 737, 1089) and the longest in women with vaginal deliveries complicated by shoulder dystocia (1193 days, 95% CI 1028, 1430). The impact of mode of delivery on subsequent rate and time to next birth was minimal in this study. The greatest reduction was among women with assisted vaginal delivery complicated by shoulder dystocia. This study is strengthened by data on pregnancy planning as well as information on complications of pregnancy, delivery and neonatal morbidities, all of which may influence a woman's decision on subsequent birth

  2. Triple probe interrogation of spokes in a HiPIMS discharge

    Science.gov (United States)

    Lockwood Estrin, F.; Karkari, S. K.; Bradley, J. W.

    2017-07-01

    Using a triple probe situated above the racetrack and inside the magnetic trap of a magnetron, rotating spoke-like structures have been clearly identified in a single HiPIMS pulse as periodic modulations of the electron temperature T e, electron density n e, ion saturation current I isat, floating potential V f and plasma potential V p. The spokes rotate in the E  ×  B direction with a velocity of ~8.8 km s-1. Defining the spoke shape from the footprint of the ion current, they deliver to flush-mounted probes embedded in the target, each spoke can be characterised by a dense but cool leading edge (n e ~ 2.0  ×  1019 m-3, T e ~ 2.1 eV) and a relatively hotter but more rarefied trailing edge (n e ~ 1  ×  1019 m-3, T e ~ 3.9 eV). Measurements of V p show a potential hump towards the rear of the spoke, separated from regions of the highest density, with plasma potentials up to 8 V more positive than the inter-spoke regions. Azimuthal electric fields of ~1 kV m-1 associated with these structures are calculated. Transforming the triple probe time-traces to functions of the azimuthal angle θ and assuming a Gaussian radial profile for the plasma parameters, 2D spatial maps of n e, T e and V p have been constructed as well as the target ion current density J p from the embedded probes. The phase relationship between T e, V p and n e can be clearly seen using this representation with n e leading T e and V p with a phase shift between them of ~50°. Regions of maximum ion current to the target, delivered by individual spokes, coincide with the overlap of regions of high n e and T e measured above the target at a height of 15 mm. Ions created at elevated positions above the target in the observed dense region will take several micro-seconds to reach that surface, so contributing to the target ion current in the following spokes.

  3. Time delay control of hydraulic manipulators with continuous nonsingular terminal sliding mode

    Institute of Scientific and Technical Information of China (English)

    王尧尧; 陈家旺; 顾临怡; 李晓东

    2015-01-01

    For the position tracking control of hydraulic manipulators, a novel method of time delay control (TDC) with continuous nonsingular terminal sliding mode (CNTSM) was proposed in this work. Complex dynamics of the hydraulic manipulator is approximately canceled by time delay estimation (TDE), which means the proposed method is model-free and no prior knowledge of the dynamics is required. Moreover, the CNTSM term with a fast-TSM-type reaching law ensures fast convergence and high-precision tracking control performance under heavy lumped uncertainties. Despite its considerable robustness against lumped uncertainties, the proposed control scheme is continuous and chattering-free and no pressure sensors are required in practical applications. Theoretical analysis and experimental results show that faster and higher-precision position tracking performance is achieved compared with the traditional CNTSM-based TDC method using boundary layers.

  4. Combination synchronization of time-delay chaotic system via robust adaptive sliding mode control

    Indian Academy of Sciences (India)

    AYUB KHAN; SHIKHA

    2017-06-01

    In this paper, the methodology to achieve combination synchronization of time-delay chaotic system via robust adaptive sliding mode control is introduced. The methodology is implemented by taking identical time-delayLorenz chaotic system. The selection of switching surface and the design of control law is also discussed, which is an important issue. By utilizing rigorous mathematical theory, sufficient condition is drawn for the stability of error dynamics based on Lyapunov stability theory. Theoretical results are supported with the numerical simulations. The complexity of this methodology is useful to strengthen the security of communication. The hidden message can be partitioned into several parts loaded in two master systems to improve the accuracy of communication.

  5. Combination synchronization of time-delay chaotic system via robust adaptive sliding mode control

    Science.gov (United States)

    Khan, Ayub; Shikha

    2017-06-01

    In this paper, the methodology to achieve combination synchronization of time-delay chaotic system via robust adaptive sliding mode control is introduced. The methodology is implemented by taking identical time-delay Lorenz chaotic system. The selection of switching surface and the design of control law is also discussed, which is an important issue. By utilizing rigorous mathematical theory, sufficient condition is drawn for the stability of error dynamics based on Lyapunov stability theory. Theoretical results are supported with the numerical simulations. The complexity of this methodology is useful to strengthen the security of communication. The hidden message can be partitioned into several parts loaded in two master systems to improve the accuracy of communication.

  6. Maximum Likelihood Timing and Carrier Synchronization in Burst-Mode Satellite Transmissions

    Directory of Open Access Journals (Sweden)

    Morelli Michele

    2007-01-01

    Full Text Available This paper investigates the joint maximum likelihood (ML estimation of the carrier frequency offset, timing error, and carrier phase in burst-mode satellite transmissions over an AWGN channel. The synchronization process is assisted by a training sequence appended in front of each burst and composed of alternating binary symbols. The use of this particular pilot pattern results into an estimation algorithm of affordable complexity that operates in a decoupled fashion. In particular, the frequency offset is measured first and independently of the other parameters. Timing and phase estimates are subsequently computed through simple closed-form expressions. The performance of the proposed scheme is investigated by computer simulation and compared with Cramer-Rao bounds. It turns out that the estimation accuracy is very close to the theoretical limits up to relatively low signal-to-noise ratios. This makes the algorithm well suited for turbo-coded transmissions operating near the Shannon limit.

  7. Maximum Likelihood Timing and Carrier Synchronization in Burst-Mode Satellite Transmissions

    Directory of Open Access Journals (Sweden)

    Michele Morelli

    2007-06-01

    Full Text Available This paper investigates the joint maximum likelihood (ML estimation of the carrier frequency offset, timing error, and carrier phase in burst-mode satellite transmissions over an AWGN channel. The synchronization process is assisted by a training sequence appended in front of each burst and composed of alternating binary symbols. The use of this particular pilot pattern results into an estimation algorithm of affordable complexity that operates in a decoupled fashion. In particular, the frequency offset is measured first and independently of the other parameters. Timing and phase estimates are subsequently computed through simple closed-form expressions. The performance of the proposed scheme is investigated by computer simulation and compared with Cramer-Rao bounds. It turns out that the estimation accuracy is very close to the theoretical limits up to relatively low signal-to-noise ratios. This makes the algorithm well suited for turbo-coded transmissions operating near the Shannon limit.

  8. Optical signal processing and tracking of whispering gallery modes in real-time for sensing applications

    Science.gov (United States)

    Ali, Amir R.; Afifi, Amr N.; Taha, Hazem

    2017-05-01

    A novel approach for tracking of whispering gallery modes (WGM) in real-time for dielectric cavities used in sensing application is presented in this paper. Real-time tracking for the shifts of the WGM can be used to measure the physical quantity of interest precisely, under high repetition rates. The tracking algorithm is based on cross-correlation signal processing technique which has been proved to be accurate in WGM shifts detection. In order to achieve portability, the aforementioned real-time algorithm is implemented using a single-board re-configurable input-output hardware. The hardware platform used combines a real-time processor and a field programmable gate array (FPGA), it also allows for data exchange between them. The tracking algorithm's accuracy and real-time behavior is verified by preforming simulations based on experiments conducted on the dielectric cavity, where the cavity is used as a force sensor measuring mechanical compression. The light from a laser diode is tuned with rates up to 10 kHz and then tangentially coupled into the cavity to excite the WGM. Results show that shifts of the WGM are tracked by the algorithm providing real-time force readings.

  9. Sliding Mode Cooperative Control for Multirobot Systems: A Finite-Time Approach

    Directory of Open Access Journals (Sweden)

    Masood Ghasemi

    2013-01-01

    Full Text Available Finite-time stability in dynamical systems theory involves systems whose trajectories converge to an equilibrium state in finite time. In this paper, we use the notion of finite-time stability to apply it to the problem of coordinated motion in multiagent systems. We consider a group of agents described by Euler-Lagrange dynamics along with a leader agent with an objective to reach and maintain a desired formation characterized by steady-state distances between the neighboring agents in finite time. We use graph theoretic notions to characterize communication topology in the network determined by the information flow directions and captured by the graph Laplacian matrix. Furthermore, using sliding mode control approach, we design decentralized control inputs for individual agents that use only data from the neighboring agents which directly communicate their state information to the current agent in order to drive the current agent to the desired steady state. We further extend these results to multiagent systems involving underactuated dynamical agents such as mobile wheeled robots. For this case, we show that while the position variables can be coordinated in finite time, the orientation variables converge to the steady states asymptotically. Finally, we validate our results experimentally using a wheeled mobile robot platform.

  10. PIM-1 as a Solution-Processable “Molecular Basket” for CO 2 Capture from Dilute Sources

    Energy Technology Data Exchange (ETDEWEB)

    Pang, Simon H.; Jue, Melinda L.; Leisen, Johannes; Jones, Christopher W.; Lively, Ryan P.

    2015-12-15

    Rising atmospheric CO2 levels have triggered recent research into the science of amine materials supported on hard, porous materials such as mesoporous silica or alumina. While such materials can give high CO2 uptakes and good sorption kinetics, they are difficult to utilize in practical applications due to difficulty in contacting large volumes of CO2-laden gases with powder materials without significant pressure drops or sorbent attrition. Here, we describe a simple approach based on the impregnation of a permanently microporous polymer, PIM-1, with poly(ethylene imine) (PEI), removing the need for use of the hard oxide. PEI/PIM-1 composites demonstrate comparable performance to more traditionally studied oxide sorbents, with the benefit that PIM-1 is soluble in common solvents, making it eminently more viable for processing into morphologies that can facilitate heat and mass transfer and fabrication into low pressure drop contactors. In addition to adsorption studies performed on a variety of PEI/PIM-1 architectures, spin diffusion NMR studies were performed to suggest that PEI is well-dispersed within the PIM-1, allowing for rapid CO2 adsorption.

  11. Challenges and perspectives in using PIMS methodology to explain the success of the marketing strategy in businesses

    Directory of Open Access Journals (Sweden)

    Rubén-Martín Mosqueda Almanza

    2011-01-01

    Full Text Available Se asume que una estrategia adecuada impactará positivamente sobre las ganancias de las empresas y las llevará a expandirse. Recientes descubrimientos sugieren que sólo con la revisión y adecuación de los elementos más relevantes del plan estratégico es posible llevar los resultados económicos de la empresa a un punto óptimo. El impacto de la estrategia de mercado en las ganancias (PIMS, en inglés constituye un modelo arquetipo para lograrlo, sin embargo, subsisten problemas fundamentales en el modelo que lo limitan. Así, en el presente trabajo se hace un estudio exploratorio de la evolución de la metodología PIMS que permite develar los retos y el posible rumbo del tema. La definición de la estrategia, el diseño de la encuesta tipo PIMS, los problemas de multicolinealidad y el efecto de la cuota de mercado se plantean como los más relevantes. Los resultados muestran la necesidad de definir con precisión la estrategia asumida por la empresa, el rediseño de la encuesta PIMS cuando se aplique a mercados incompletos y, finalmente, se advierte un avance en el estudio econométrico de PIMS poniendo énfasis en la variable calidad relativa del producto para resolver el viejo dilema del efecto de la cuota de mercado.

  12. Empirical mode decomposition and k-nearest embedding vectors for timely analyses of antibiotic resistance trends.

    Directory of Open Access Journals (Sweden)

    Douglas Teodoro

    Full Text Available BACKGROUND: Antibiotic resistance is a major worldwide public health concern. In clinical settings, timely antibiotic resistance information is key for care providers as it allows appropriate targeted treatment or improved empirical treatment when the specific results of the patient are not yet available. OBJECTIVE: To improve antibiotic resistance trend analysis algorithms by building a novel, fully data-driven forecasting method from the combination of trend extraction and machine learning models for enhanced biosurveillance systems. METHODS: We investigate a robust model for extraction and forecasting of antibiotic resistance trends using a decade of microbiology data. Our method consists of breaking down the resistance time series into independent oscillatory components via the empirical mode decomposition technique. The resulting waveforms describing intrinsic resistance trends serve as the input for the forecasting algorithm. The algorithm applies the delay coordinate embedding theorem together with the k-nearest neighbor framework to project mappings from past events into the future dimension and estimate the resistance levels. RESULTS: The algorithms that decompose the resistance time series and filter out high frequency components showed statistically significant performance improvements in comparison with a benchmark random walk model. We present further qualitative use-cases of antibiotic resistance trend extraction, where empirical mode decomposition was applied to highlight the specificities of the resistance trends. CONCLUSION: The decomposition of the raw signal was found not only to yield valuable insight into the resistance evolution, but also to produce novel models of resistance forecasters with boosted prediction performance, which could be utilized as a complementary method in the analysis of antibiotic resistance trends.

  13. Vibrational mode suppression in the non-Markovian limit : Diagonal time-gating of the stimulated photon echo

    NARCIS (Netherlands)

    De Boeij, W. P.; Pshenichnikov, M. S.; Wiersma, D. A.

    1996-01-01

    We demonstrate a novel technique for efficient vibrational mode suppression in stimulated photon echo by diagonal time-gating. This is especially important if the system exhibits non-Markovian optical dynamics.

  14. Mixed-mode oscillations in a multiple time scale phantom bursting system

    CERN Document Server

    Krupa, Maciej; Desroches, Mathieu; Clément, Frédérique

    2012-01-01

    In this work we study mixed mode oscillations in a model of secretion of GnRH (Gonadotropin Releasing Hormone). The model is a phantom burster consisting of two feedforward coupled FitzHugh-Nagumo systems, with three time scales. The forcing system (Regulator) evolves on the slowest scale and acts by moving the slow nullcline of the forced system (Secretor). There are three modes of dynamics: pulsatility (transient relaxation oscillation), surge (quasi steady state) and small oscillations related to the passage of the slow nullcline through a fold point of the fast nullcline. We derive a variety of reductions, taking advantage of the mentioned features of the system. We obtain two results; one on the local dynamics near the fold in the parameter regime corresponding to the presence of small oscillations and the other on the global dynamics, more specifically on the existence of an attracting limit cycle. Our local result is a rigorous characterization of small canards and sectors of rotation in the case of fo...

  15. Time-dependent mode structure for Lyapunov vectors as a collective movement in quasi-one-dimensional systems.

    Science.gov (United States)

    Taniguchi, Tooru; Morriss, Gary P

    2005-01-01

    The time-dependent mode structure of the Lyapunov vectors associated with the stepwise structure of the Lyapunov spectra and its relation to the momentum autocorrelation function are discussed in quasi-one-dimensional many-hard-disk systems. We obtain the complete mode structures (Lyapunov modes) for all components of the Lyapunov vectors, including the longitudinal and transverse components of both the spatial and momentum parts, and their phase relations. These mode structures are suggested by the form of the Lyapunov vectors for the zero-Lyapunov exponents. The spatial node structures of these modes are explained by the reflection properties of the hard walls used in the models. Our main result is that the largest time-oscillating period of the Lyapunov modes is twice as long as the time-oscillating period of the longitudinal momentum autocorrelation function. This relation is satisfied irrespective of the number of particles and the boundary conditions. A simple explanation for this relation is given based on the form of the time-dependent Lyapunov mode.

  16. Finite-time synchronization for second-order nonlinear multi-agent system via pinning exponent sliding mode control.

    Science.gov (United States)

    Hou, Huazhou; Zhang, Qingling

    2016-11-01

    In this paper we investigate the finite-time synchronization for second-order multi-agent system via pinning exponent sliding mode control. Firstly, for the nonlinear multi-agent system, differential mean value theorem is employed to transfer the nonlinear system into linear system, then, by pinning only one node in the system with novel exponent sliding mode control, we can achieve synchronization in finite time. Secondly, considering the 3-DOF helicopter system with nonlinear dynamics and disturbances, the novel exponent sliding mode control protocol is applied to only one node to achieve the synchronization. Finally, the simulation results show the effectiveness and the advantages of the proposed method.

  17. Analysis of time-resolved PIV measurements of a confined turbulent jet using POD and Koopman modes

    Energy Technology Data Exchange (ETDEWEB)

    Semeraro, Onofrio; Lundell, Fredrik [KTH Mechanics, Linne Flow Centre, Stockholm (Sweden); Bellani, Gabriele [KTH Mechanics, Linne Flow Centre, Stockholm (Sweden); University of California, Department of Civil and Environmental Engineering, Berkeley, CA (United States)

    2012-11-15

    We present a comparative analysis of proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD) computed from experimental data of a turbulent, quasi 2-D, confined jet with co-flow (Re = 11,500, co-flow ratio inner-to-outer flow {approx}2:1). The experimental data come from high-speed 2-D particle image velocimetry. The flow is fully turbulent, and it contains geometry-dependent large-scale coherent structures; thus, it provides an interesting benchmark case for the comparison between POD and DMD. In this work, we address issues related to snapshot selections (1), convergence (2) and the physical interpretation (3) of both POD and DMD modes. We found that the convergence of POD modes follows the criteria of statistical convergence of the autocovariance matrix. For the computation of DMD modes, we suggest a methodology based on two criteria: the analysis of the residuals to optimize the sampling parameters of the snapshots, and a time-shifting procedure that allows us to identify the spurious modes and retain the modes that consistently appear in the spectrum. These modes are found to be the ones with nearly null growth rate. We then present the selected modes, and we discuss the way POD and DMD rank them. POD analysis reveals that the most energetic spatial structures are related to the large-scale oscillation of the inner jet (flapping); from the temporal analysis emerges that these modes are associated with a low-frequency peak at St = 0.02. At this frequency, DMD identifies a similar mode, where oblique structures from the walls appear together with the flapping mode. The second most energetic group of modes identified is associated with shear-layer oscillations, and to a recirculation zone near the inner jet. Temporal analysis of these modes shows that the flapping of the inner jet might be sustained by the recirculation. In the DMD, the shear-layer modes are separated from the recirculation modes. These have large amplitudes in the DMD. In

  18. Reformulation of time-convolutionless mode-coupling theory near the glass transition

    Science.gov (United States)

    Tokuyama, Michio

    2017-10-01

    The time-convolutionless mode-coupling theory (TMCT) recently proposed is reformulated under the condition that one of two approximations, which have been used to formulate the original TMCT in addition to the MCT approximations done on a derivation of nonlinear memory function in terms of the intermediate-scattering function, is not employed because it causes unphysical results for intermediate times. The improved TMCT equation is then derived consistently under another approximation. It is first checked that the ergodic to non-ergodic transition obtained by a new equation is exactly the same as that obtained by an old one because the long-time dynamics of both equations coincides with each other. However, it is emphasized that a difference between them appears in the intermediate-time dynamics of physical quantities. Such a difference is explored numerically in the dynamics of a non-Gaussian parameter by employing the Percus-Yevick static structure factor to calculate the nonlinear memory function.

  19. Mixed-Mode Oscillations in a piecewise linear system with multiple time scale coupling

    Science.gov (United States)

    Fernández-García, S.; Krupa, M.; Clément, F.

    2016-10-01

    In this work, we analyze a four dimensional slow-fast piecewise linear system with three time scales presenting Mixed-Mode Oscillations. The system possesses an attractive limit cycle along which oscillations of three different amplitudes and frequencies can appear, namely, small oscillations, pulses (medium amplitude) and one surge (largest amplitude). In addition to proving the existence and attractiveness of the limit cycle, we focus our attention on the canard phenomena underlying the changes in the number of small oscillations and pulses. We analyze locally the existence of secondary canards leading to the addition or subtraction of one small oscillation and describe how this change is globally compensated for or not with the addition or subtraction of one pulse.

  20. A Versatile Discrete-Time Approach for Modeling Switch-Mode Controllers

    DEFF Research Database (Denmark)

    Risbo, Lars; Høyerby, Mikkel Christian Wendelboe; Andersen, Michael Andreas E.

    2008-01-01

    is demonstrated to allow very precise predictions of comparator frequency response in a variety of control schemes. In the presented work, the modeling method is exemplified for the standard PWM and two different self-oscillating (a.k.a. sliding mode) control schemes. The proposed method is believed......This paper presents a universal method for modeling the frequency response of comparators in switchmode controllers. As the main non-linearity in most switchmode controllers, understanding the comparator is the key to understanding the system. Based on discrete-time modeling, the proposed method...... by the authors to be the first method that is able to handle these fundamentally different control schemes within a single modeling framework. Experimentally measured output impedance and comparator magnitude responses are compared to the model results. Great accuracy is achieved from DC to frequencies far...

  1. Variable speed wind turbine control by discrete-time sliding mode approach.

    Science.gov (United States)

    Torchani, Borhen; Sellami, Anis; Garcia, Germain

    2016-05-01

    The aim of this paper is to propose a new design variable speed wind turbine control by discrete-time sliding mode approach. This methodology is designed for linear saturated system. The saturation constraint is reported on inputs vector. To this end, the back stepping design procedure is followed to construct a suitable sliding manifold that guarantees the attainment of a stabilization control objective. It is well known that the mechanisms are investigated in term of the most proposed assumptions to deal with the damping, shaft stiffness and inertia effect of the gear. The objectives are to synthesize robust controllers that maximize the energy extracted from wind, while reducing mechanical loads and rotor speed tracking combined with an electromagnetic torque. Simulation results of the proposed scheme are presented.

  2. Joint Temperature-Lasing Mode Compensation for Time-of-Flight LiDAR Sensors

    Directory of Open Access Journals (Sweden)

    Anas Alhashimi

    2015-12-01

    Full Text Available We propose an expectation maximization (EM strategy for improving the precision of time of flight (ToF light detection and ranging (LiDAR scanners. The novel algorithm statistically accounts not only for the bias induced by temperature changes in the laser diode, but also for the multi-modality of the measurement noises that is induced by mode-hopping effects. Instrumental to the proposed EM algorithm, we also describe a general thermal dynamics model that can be learned either from just input-output data or from a combination of simple temperature experiments and information from the laser’s datasheet. We test the strategy on a SICK LMS 200 device and improve its average absolute error by a factor of three.

  3. Robust sliding mode control of general time-varying delay stochastic systems with structural uncertainties

    Institute of Scientific and Technical Information of China (English)

    Sheng-Guo WANG; Libin BAI; Mingzhi CHEN

    2014-01-01

    This paper presents a new robust sliding mode control (SMC) method with well-developed theoretical proof for general uncertain time-varying delay stochastic systems with structural uncertainties and the Brownian noise (Wiener process). The key features of the proposed method are to apply singular value decomposition (SVD) to all structural uncertainties and to introduce adjustable parameters for control design along with the SMC method. It leads to a less-conservative condition for robust stability and a new robust controller for the general uncertain stochastic systems via linear matrix inequality (LMI) forms. The system states are able to reach the SMC switching surface as guaranteed in probability 1. Furthermore, it is theoretically proved that the proposed method with the SVD and adjustable parameters is less conservatism than the method without the SVD. The paper is mainly to provide all strict theoretical proofs for the method and results.

  4. Manufacturing the LINAC4 PI-Mode Structure Prototype at CERN

    CERN Document Server

    Favre, A; Dallocchio, A; Geisser, J M; Gentini, L; Gerigk, L; Mathot, S; Polini, M; Sgobba, S; Tardy, T; Wegner, R

    2011-01-01

    The PI-Mode Structure (PIMS) of Linac4 consists of 7-cell cavities made from alternating OFE copper discs and rings welded together with electron beam (EB) welding. A full-scale prototype cavity of almost 1.5 m in length has been manufactured, assembled, and tested at CERN to prepare the series production of 12 PIMS cavities as part of an international collaboration. This paper reports on the construction experience including machining operations, EB welding, vacuum brazing, and metrological measurements results.

  5. Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors.

    Directory of Open Access Journals (Sweden)

    Gustavo Saluste

    Full Text Available A new chemical series, triazolo[4,5-b]pyridines, has been identified as an inhibitor of PIM-1 by a chemotype hopping strategy based on a chemically feasible fragment database. In this case, structure-based virtual screening and in silico chemogenomics provide added value to the previously reported strategy of prioritizing among proposed novel scaffolds. Pairwise comparison between compound 3, recently discontinued from Phase I clinical trials, and molecule 8, bearing the selected novel scaffold, shows that the primary activities are similar (IC(50 in the 20 to 150 nM range. At the same time, some ADME properties (for example, an increase of more than 45% in metabolic stability in human liver microsomes and the off-target selectivity (for example, an increase of more than 2 log units in IC(50vs. FLT3 are improved, and the intellectual property (IP position is enhanced. The discovery of a reliable starting point that fulfills critical criteria for a plausible medicinal chemistry project is demonstrated in this prospective study.

  6. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

    Science.gov (United States)

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L.; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M.; Wilter da Silva, Alan; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S.; Stuart, David I.; Henrick, Kim; Esnouf, Robert M.

    2011-01-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service. PMID:21460443

  7. Comparison between the Requirements of Flowability and Moldability and the Shape Retention of PIM Compacts during Debinding Process

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To successfully employ powder injection molding (PIM) as a manufacturing technique, the function of the component, design of the part, material and process should be optimized for overall processing ability of the PIM process. A comparison between the requirements of flowability and moldability and the compacts shape retention has been made in this work. There is often a contradiction between the requirements of flowability and the compacts shape retention. Many works have been done to attain good molding conditions. However, they fail to take into accountthe effect of some factors that satisfies good molding conditions on the compacts shape reten-tion during debinding. This paper studies the effect of the powder-binder mixture characteristicsand the molding conditions on the flowability and moldability and the shape retention of PIM compacts during debinding process so as to attain the benefits of each.

  8. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.

    Science.gov (United States)

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M; da Silva, Alan Wilter; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S; Stuart, David I; Henrick, Kim; Esnouf, Robert M

    2011-04-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

  9. Reusable Launch Vehicle Attitude Control Using a Time-Varying Sliding Mode Control Technique

    Science.gov (United States)

    Shtessel, Yuri B.; Zhu, J. Jim; Daniels, Dan; Jackson, Scott (Technical Monitor)

    2002-01-01

    In this paper we present a time-varying sliding mode control (TVSMC) technique for reusable launch vehicle (RLV) attitude control in ascent and entry flight phases. In ascent flight the guidance commands Euler roll, pitch and yaw angles, and in entry flight it commands the aerodynamic angles of bank, attack and sideslip. The controller employs a body rate inner loop and the attitude outer loop, which are separated in time-scale by the singular perturbation principle. The novelty of the TVSMC is that both the sliding surface and the boundary layer dynamics can be varied in real time using the PD-eigenvalue assignment technique. This salient feature is used to cope with control command saturation and integrator windup in the presence of severe disturbance or control effector failure, which enhances the robustness and fault tolerance of the controller. The TV-SMC ascent and descent designs are currently being tested with high fidelity, 6-DOF dispersion simulations. The test results will be presented in the final version of this paper.

  10. Energetically optimal nonstationary mode of flow along tube with constant and time-varying radius

    Directory of Open Access Journals (Sweden)

    Sergey G. Chefranov

    2016-11-01

    Full Text Available Derived is a new modification of hydrodynamic equations of viscous incompressible fluid flowing along the tube with radius changing in time. Obtained are exact non-stationary solutions of these equations generalizing a well-known classic stationary solution for Hagen–Poiseuille flow in the tube with radius constant in time. It is demonstrated that the law of changing the tube radius in time may be determined basing on the condition of minimality of the work expended for flowing the set fluid volume along such a tube during the period of radius change cycle. Obtained is the solution of the corresponding variational (isoperimetric problem on conditional extremum determining the limits to dimensionless quantity of the cycle duration set by the specified dimensionless value of the flowed fluid volume. Identified is the generalization of well-known model of optimal branching pipeline (F.L. Chernous’ko, 1977 in which the Poiseuille law modification is used for a new exact non-stationary solution of hydrodynamic equation instead of the law itself. It is demonstrated that the energetically favorable non-stationary modes with negative hydraulic resistance are permissible in certain conditions. The obtained conclusions may be used for development of the hydrodynamic basis of modelling the energy-optimal blood flow realized in the cardiovascular system in norm.

  11. Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry

    OpenAIRE

    Park, Chorong; Min, Saehong; Park, Eun-Mee; Lim, Yun-Sook; Kang, Sangmin; Suzuki, Tetsuro; Shin, Eui-Cheol; Hwang, Soon B.

    2015-01-01

    The life cycle of hepatitis C virus (HCV) is highly dependent on host cellular proteins for virus propagation. In order to identify the cellular factors involved in HCV propagation, we performed protein microarray assay using the HCV nonstructural 5A (NS5A) protein as a probe. Of ∼9,000 human cellular proteins immobilized in a microarray, approximately 90 cellular proteins were identified as NS5A interactors. Of these candidates, Pim1, a member of serine/threonine kinase family composed of th...

  12. Polymer Inclusion Membranes (PIM) for the Recovery of Potassium in the Presence of Competitive Cations

    OpenAIRE

    2016-01-01

    Potassium is an important nutrient used in fertilizers but is not always naturally available  We investigated the properties of polymer inclusion membranes (PIM) regarding their selective recovery of K+ over competitive ions typically present in urine (Na+ and NH4+). The greatest flux was observed when the ratio of mass 2-nitrophenyl octyl ether (2-NPOE) used as plasticizer to cellulose triacetate (CTA) used as polymer was 0.25. The highest flux was achieved with a content of 24.8 wt % of dic...

  13. Discriminator amplitude walk correction in gamma-ray coincidence experiments using list-mode time-stamping data acquisition

    Science.gov (United States)

    Khamzin, Murat K.; Valentine, John D.

    2003-06-01

    When pulse amplitude and time stamp are recorded in list-mode time-stamping data acquisition, it is possible to correct for the system amplitude walk, typically observed as the time pickoff dependence on pulse amplitude. In this study, a method of correcting for amplitude walk during post-acquisition analysis of such list mode data is developed and demonstrated. The method is demonstrated using a simple two-channel system and a photon source capable of producing coincidence events ( 22Na). Two leading-edge discriminators, vulnerable to the amplitude walk, were used to produce the time pickoffs. The resulting corrected data show an amplitude walk less than the detector timing resolution. The method developed can be used in list-mode data acquisition systems such as medical imaging scanners or Compton scatter cameras.

  14. Mode-locking optimization with a real-time feedback system in a Nd:yttrium lithium fluoride laser cavity

    Science.gov (United States)

    Marengoni, C.; Canova, F.; Batani, D.; Benocci, R.; Librizzi, M.; Narayanan, V.; Gomareschi, M.; Lucchini, G.; Kilpio, A.; Shashkov, E.; Stuchebrukhov, I.; Vovchenko, V.; Chernomyrdin, V.; Krasuyk, I.; Hall, T.; Bittanti, S.

    2007-01-01

    We present a control system, which allows an automatic optimization of the pulse train stability in a mode-locked laser cavity. In order to obtain real-time corrections, we chose a closed loop approach. The control variable is the cavity length, mechanically adjusted by gear system acting on the rear cavity mirror, and the controlled variable is the envelope modulation of the mode-locked pulse train. Such automatic control system maintains the amplitude of the mode-locking pulse train stable within a few percent rms during the working time of the laser. Full implementation of the system on an Nd:yttrium lithium fluoride actively mode-locked laser is presented.

  15. Research on AIDS patients’ survival time after highly active antiretroviral therapy, treatment effect and treatment modes

    Directory of Open Access Journals (Sweden)

    Riying Lv

    2016-05-01

    Full Text Available To fully define clinical efficacy of highly active antiretroviral therapy for AIDS, analyze patients’ survival time and treatment mode after receiving treatment, and provide scientific theory to guide improvement of antiviral therapy, this paper selected 3100 cases of patients diagnosed with AIDS during April 2006 and April 2014 as object of this study. All patients were treated with highly active antiretroviral therapy. The main analysis contents of this study include CD4 + T lymphocyte count, viral load changes, incidence of opportunistic infections, specific cause of death and the like. The results show that patients’ CD4 + T lymphocyte levels are significantly increased 3, 18, and 24 months after treatment, difference between the situation after and before receiving treatment, P < 0.05, with statistically significant difference. Analyzed from effective inhibition of virus, effective inhibition rate is 72.58.0% (2250/3100. Main causes of death in patients is usually respiratory failure. It thus can be concluded that highly active antiretroviral therapy for AIDS is with good clinical effect, which can effectively improve survival time of patients. So it enjoys application value of being widely used in clinical treatment of AIDS.

  16. PE-CMOS-based C-mode ultrasound: signal acquisition and time gating

    Science.gov (United States)

    Lo, Shih-Chung B.; Liu, Chu-Chuan; Freedman, Matthew T.; Mun, Seong-Ki; Kula, John; Lasser, Marvin E.; Lasser, Bob; Wang, Yue Joseph

    2009-02-01

    Two types of signal acquisition methods using CMOS sensor array coated with piezoelectric material (PE-CMOS) were studied. The laboratory projection-reflection ultrasound prototypes featuring a PE-CMOS ultrasound sensing array and an acoustic compound lens were employed to image pork bones with fractures in vitro. We found that the projection-reflection ultrasound prototypes are capable of revealing hairline bone fractures with skin in tact. However, the image characteristics generated from these C-scan prototypes are somewhat different because they were equipped with two different senor array models. The signal acquired by the first sensor model is based on an integrated signal (IS) at a given time interval. But the signal acquired by the second sensor model is based on peak signal (PS) with a time gating function controllable by the user. We found that both systems can detect bone fracture as small as 0.5mm shown as a strip of ultrasound signal. However, images obtained from the IS sensor show more speckles with a greater blooming effect on the fractures. On the other hand, images obtained from the PS sensor show less contrast with less speckles. When the beam position is slightly tilted from the normal direction, the blooming effect of the ultrasound image would become dark on the fracture region with both acquisition modes.

  17. Real-time sawtooth control and neoclassical tearing mode preemption in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D., E-mail: doohyun.kim@epfl.ch; Goodman, T. P.; Sauter, O. [École Polytechnique Fédérale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland)

    2014-06-15

    Real-time control of multiple plasma actuators is a requirement in advanced tokamaks; for example, for burn control, plasma current profile control and MHD stabilization—electron cyclotron (EC) wave absorption is ideally suited especially for the latter. On ITER, 24 EC sources can be switched between 56 inputs at the torus. In the torus, 5 launchers direct the power to various locations across the plasma profile via 11 steerable mirrors. For optimal usage of the available power, the aiming and polarization of the beams must be adapted to the plasma configuration and the needs of the scenario. Since the EC system performs many competing tasks, present day systems should demonstrate the ability of an EC plant to deal with several targets in parallel and/or to switch smoothly between goals to attain overall satisfaction. Based on pacing and locking experiments performed on TCV (Tokamak à Configuration Variable), the real-time sawtooth control of ITER with this complex set of actuators is analyzed, as an example. It is shown that sawtooth locking and pacing are possible with various levels of powers, leading to different time delays between the end of the EC power phase and the next sawtooth crash. This timing is important since it allows use of the same launchers for neoclassical tearing mode (NTM) preemption at the q = 1.5 or 2 surface, avoiding the need to switch power between launchers. These options are presented. It is also demonstrated that increasing the total EC power does not necessarily increase the range of control because of the geometry of the launchers.

  18. Time Evolution Caused by Hamiltonian Composed of Quadratic Combination of Canonical Operators and Time-Dependent Two-Mode Fresnel Operator

    Institute of Scientific and Technical Information of China (English)

    FAN Hong-Yi; LU Hai-Liang

    2006-01-01

    We show that the time-dependent two-mode Fresnel operator is just the time-evolutional unitary operator governed by the Hamiltonian composed of quadratic combination of canonical operators in the way of exhibiting SU(1,1)algebra. This is an approach for obtaining the time-dependent Hamiltonian from the preassigned time evolution in classical phase space, an approach which is in contrast to Lewis-Riesenfeld's invariant operator theory of treating time-dependent harmonic oscillators.

  19. Robust control of uncertain time delay system: a novel sliding mode control design via LMI

    Institute of Scientific and Technical Information of China (English)

    Qu Shaocheng; Wang Yongji

    2006-01-01

    The sliding mode control problem (SMC) is studied for a class of uncertain delay system in the presence of both parameter uncertainties and external disturbances. A novel virtual feedback control method is presented. Based on Lyapunov theory, sufficient conditions for design of the robust sliding mode plane are derived. Sliding mode controller based on reaching law concept is developed, which is to ensure system trajectories from any initial conditions asymptotically convergent to sliding mode plane. The global asymptotically stability of the closed-loop system is guaranteed. A numerical example with simulation results is given to illustrate the effectiveness of the methodology.

  20. Robust Stability for Nonlinear Systems with Time-Varying Delay and Uncertainties via the H∞ Quasi-Sliding Mode Control

    OpenAIRE

    Yi-You Hou; Zhang-Lin Wan

    2014-01-01

    This paper considers the problem of the robust stability for the nonlinear system with time-varying delay and parameters uncertainties. Based on the H∞ theorem, Lyapunov-Krasovskii theory, and linear matrix inequality (LMI) optimization technique, the H∞ quasi-sliding mode controller and switching function are developed such that the nonlinear system is asymptotically stable in the quasi-sliding mode and satisfies the disturbance attenuation (H∞-norm performance). The effectiveness and accura...

  1. Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro.

    Science.gov (United States)

    Lim, Ratana; Barker, Gillian; Lappas, Martha

    2017-06-01

    Does proviral integration site for Moloney murine leukaemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? PIM1 kinase plays a critical role in foetal membranes in regulating pro-inflammatory and pro-labour mediators. Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes. PIM1 has been shown to have a role in immune regulation and inflammation in non-gestational tissues; however, its role has not been explored in the field of human labour. PIM1 expression was analysed in myometrium and/or foetal membranes obtained at term and preterm (n = 8-9 patients per group). Foetal membranes, freshly isolated amnion cells and primary myometrial cells were used to investigate the effect of PIM1 inhibition on pro-labour mediators (n = 5 patients per treatment group). Foetal membranes, from term and preterm, were obtained from non-labouring and labouring women, and from preterm pre-labour rupture of membranes (PPROM) (n = 9 per group). Amnion was collected from women with and without preterm chorioamnionitis (n = 8 per group). Expression of PIM1 kinase was determined by qRT-PCR and western blotting. To determine the effect of PIM1 kinase inhibition on the expression of pro-inflammatory and pro-labour mediators induced by bacterial products lipopolysaccharide (LPS) (10 μg/ml) and flagellin (1 μg/ml) and pro-inflammatory cytokine tumour necrosis factor (TNF) (10 ng/ml), chemical inhibitors SMI-4a (20 μM) and AZD1208 (50 μM) were used in foetal membrane explants and siRNA against PIM1 was used in primary amnion cells. Statistical significance was set at P pro-inflammatory cytokine interleukin-6 (IL6) and chemokines CXCL8 and CCL2 mRNA and release, prostaglandin prostaglandin F2α (PGF2α) release, adhesion molecule intercellular adhesion molecule 1 mRNA expression and release, and

  2. Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.

    Science.gov (United States)

    Cozza, Giorgio; Sarno, Stefania; Ruzzene, Maria; Girardi, Cristina; Orzeszko, Andrzej; Kazimierczuk, Zygmunt; Zagotto, Giuseppe; Bonaiuto, Emanuela; Di Paolo, Maria Luisa; Pinna, Lorenzo A

    2013-07-01

    Advantage has been taken of the relative promiscuity of commonly used inhibitors of protein kinase CK2 to develop compounds that can be exploited for the selective inhibition of druggable kinases other than CK2 itself. Here we summarize data obtained by altering the scaffold of CK2 inhibitors to give rise to novel selective inhibitors of DYRK1A and to a powerful cell permeable dual inhibitor of PIM1 and CK2. In the former case one of the new compounds, C624 (naphto [1,2-b]benzofuran-5,9-diol) displays a potency comparable to that of the first-in-class DYRK1A inhibitor, harmine, lacking however the drawback of drastically inhibiting monoamine oxidase-A (MAO-A) as harmine does. On the other hand the promiscuous CK2 inhibitor 4,5,6,7-tetrabromo-1H-benzimidazole (TBI,TBBz) has been derivatized with a sugar moiety to generate a 1-(β-D-2'-deoxyribofuranosyl)-4,5,6,7-tetrabromo-1H-benzimidazole (TDB) compound which inhibits PIM1 and CK2 with comparably high efficacy (IC50 valuescancer cells consistent with concomitant inhibition of both its onco-kinase targets. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).

  3. Polymer Inclusion Membranes (PIM for the Recovery of Potassium in the Presence of Competitive Cations

    Directory of Open Access Journals (Sweden)

    Anna Casadellà

    2016-03-01

    Full Text Available Potassium is an important nutrient used in fertilizers but is not always naturally available  We investigated the properties of polymer inclusion membranes (PIM regarding their selective recovery of K+ over competitive ions typically present in urine (Na+ and NH4+. The greatest flux was observed when the ratio of mass 2-nitrophenyl octyl ether (2-NPOE used as plasticizer to cellulose triacetate (CTA used as polymer was 0.25. The highest flux was achieved with a content of 24.8 wt % of dicyclohexan-18-crown-6 (DCH18C6 used as carrier, although the highest selectivity was observed with a content of 14.0 wt % of DCH18C6. We also studied whether the transport mechanism occurring in our system was based on co-transport of a counter-ion or ion exchange. Two different receiving phases (ultrapure water and 100 mM HCl were tested. Results on transport mechanisms suggest that co-transport of cations and anions is taking place across our PIMs. The membrane deteriorated and lost its properties when the receiving phase was acidic; we suggested that this was due to hydrolysis of CTA. The greatest flux and selectivity were observed in ultrapure water as receiving phase.

  4. Adaptive switching gain for a discrete-time sliding mode controller

    NARCIS (Netherlands)

    Monsees, G.; Scherpen, J.M.A.

    2002-01-01

    Sliding mode control is a well-known technique capable of making the closed loop system robust with respect to certain kinds of parameter variations and unmodelled dynamics. The sliding mode control law consists of a continuous component which is based on the model knowledge and discontinuous compon

  5. Adaptive Switching Gain for a Discrete-Time Sliding Mode Controller

    NARCIS (Netherlands)

    Monsees, G.; Scherpen, J.M.A.

    2000-01-01

    Sliding Mode Control is a well-known technique capable of making the closed loop system robust with respect to certain kinds of parameter variations and unmodeled dynamics. The sliding mode control law consists of the linear control part which is based on the model knowledge and the discontinuous co

  6. Acoustic Defect-Mode Waveguides Fabricated in Sonic Crystal: Numerical Analyses by Elastic Finite-Difference Time-Domain Method

    Science.gov (United States)

    Miyashita, Toyokatsu

    2006-05-01

    A novel acoustic waveguide composed of a line of single defects in a sonic crystal is shown to have desirable properties for acoustic circuits. The absence of a scatterer, i.e., a single defect or a point defect, in artificial crystals such as photonic crystals and phononic crystals leads to some localized resonant modes around the defect. Single defects in a sonic crystal made of acrylic resin cylinders in air are shown in this paper to have resonant modes or defect modes, which are excited successively to form a mode guided along a line of defects. Both a straight waveguide and a sharp bending waveguide composed of lines of single defects are shown equally to have a good transmission with small reflections at the inlet as well as at the outlet within the full band gap of the sonic crystal. Their advantages over conventional line-defect waveguides are clearly shown by their transmission versus frequency characteristics and also by typical examples of their spatial acoustic field distribution. On the basis of these properties, coupled defect-mode waveguides are investigated, and a high mode-coupling ratio is obtained. Defect-mode waveguides in a sonic crystal are expected to be desirable elements for functional acoustic circuits. The results of the elastic finite difference time domain (FDTD) method used as a tool of numerical calculation are also investigated and precisely compared with the experimental band gaps.

  7. Real-Time Detection of Staphylococcus Aureus Using Whispering Gallery Mode Optical Microdisks

    Directory of Open Access Journals (Sweden)

    Hala Ghali

    2016-05-01

    Full Text Available Whispering Gallery Mode (WGM microresonators have recently been studied as a means to achieve real-time label-free detection of biological targets such as virus particles, specific DNA sequences, or proteins. Due to their high quality (Q factors, WGM resonators can be highly sensitive. A biosensor also needs to be selective, requiring proper functionalization of its surface with the appropriate ligand that will attach the biomolecule of interest. In this paper, WGM microdisks are used as biosensors for detection of Staphylococcus aureus. The microdisks are functionalized with LysK, a phage protein specific for staphylococci at the genus level. A binding event on the surface shifts the resonance peak of the microdisk resonator towards longer wavelengths. This reactive shift can be used to estimate the surface density of bacteria that bind to the surface of the resonator. The limit of detection of a microdisk with a Q-factor around 104 is on the order of 5 pg/mL, corresponding to 20 cells. No binding of Escherichia coli to the resonators is seen, supporting the specificity of the functionalization scheme.

  8. Real-time tumor ablation simulation based on the dynamic mode decomposition method

    KAUST Repository

    Bourantas, George C.

    2014-05-01

    Purpose: The dynamic mode decomposition (DMD) method is used to provide a reliable forecasting of tumor ablation treatment simulation in real time, which is quite needed in medical practice. To achieve this, an extended Pennes bioheat model must be employed, taking into account both the water evaporation phenomenon and the tissue damage during tumor ablation. Methods: A meshless point collocation solver is used for the numerical solution of the governing equations. The results obtained are used by the DMD method for forecasting the numerical solution faster than the meshless solver. The procedure is first validated against analytical and numerical predictions for simple problems. The DMD method is then applied to three-dimensional simulations that involve modeling of tumor ablation and account for metabolic heat generation, blood perfusion, and heat ablation using realistic values for the various parameters. Results: The present method offers very fast numerical solution to bioheat transfer, which is of clinical significance in medical practice. It also sidesteps the mathematical treatment of boundaries between tumor and healthy tissue, which is usually a tedious procedure with some inevitable degree of approximation. The DMD method provides excellent predictions of the temperature profile in tumors and in the healthy parts of the tissue, for linear and nonlinear thermal properties of the tissue. Conclusions: The low computational cost renders the use of DMD suitable forin situ real time tumor ablation simulations without sacrificing accuracy. In such a way, the tumor ablation treatment planning is feasible using just a personal computer thanks to the simplicity of the numerical procedure used. The geometrical data can be provided directly by medical image modalities used in everyday practice. © 2014 American Association of Physicists in Medicine.

  9. Time delay controlled annular array transducers for omnidirectional guided wave mode control in plate like structures

    Science.gov (United States)

    Koduru, Jaya P.; Rose, Joseph L.

    2014-10-01

    Guided waves in plate like structures offer several modes with unique characteristics that can be taken advantage for nondestructive inspection applications. Conditions relating to the structure under inspection like the surrounding media, liquid loading, coatings etc require the use of special modes for successful inspection. Therefore, transducers that can excite mode controlled guided waves are essential for defect detection and discrimination in structures. Array transducers with annular elements can generate omnidirectional guided waves in plate like structures. However, the wave modes excited are limited to a particular wavelength governed by the element spacing. This limitation on the annular array transducers can be overcome by controlling the phase at each element relative to one another. In this work, annular array transducer construction techniques are theoretically examined and the optimum phase delays between the annular elements to excite a desired guided wave mode are calculated. A five element comb type annular array transducer is fabricated utilizing 1-3 type piezocomposite material. The mode control capability of the transducer is experimentally verified by selectively exciting the A0 and S0 guided wave modes in an aluminum plate like structure.

  10. Design of fuzzy sliding mode controller for SISO discrete-time systems

    Institute of Scientific and Technical Information of China (English)

    Yang MI; Yuanwei JING

    2004-01-01

    According to a class of nonlinear SISO discrete systems,the fuzzy sliding mode control problem is considered.Based on Takagi-Sugeno fuzzy model method,a fuzzy model is designed to describe the local dynamic performance of the given nonlinear systems.By using the sliding mode control approach,the global controller is constructed by integrating all the local state controllers and the global supervisory sliding mode controller.The tracking problem can be easily dealt with by taking advantage of the combined controller,and the robustness performance is improved finally.A simulation example is given to show the effectiveness and feasibility of the method proposed.

  11. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression

    Science.gov (United States)

    Horiuchi, Dai; Camarda, Roman; Zhou, Alicia Y.; Yau, Christina; Momcilovic, Olga; Balakrishnan, Sanjeev; Corella, Alexandra N.; Eyob, Henok; Kessenbrock, Kai; Lawson, Devon A.; Marsh, Lindsey A.; Anderton, Brittany N.; Rohrberg, Julia; Kunder, Ratika; Bazarov, Alexey V.; Yaswen, Paul; McManus, Michael T.; Rugo, Hope S.; Werb, Zena; Goga, Andrei

    2017-01-01

    Triple-negative breast cancer (TNBC), which lacks the expression of the estrogen, progesterone, and HER2 receptors, represents the breast cancer subtype with the poorest outcome1. No targeted therapy is available against this subtype due to lack of validated molecular targets. We previously reported that MYC signaling is disproportionally elevated in triple-negative (TN) tumors compared to receptor-positive (RP) tumors2. MYC is an essential, pleiotropic transcription factor that regulates the expression of hundreds of genes3. Direct inhibition of oncogenic MYC transcriptional activity has remained challenging4,5. The present study conducted an shRNA screen against all kinases to uncover novel MYC-dependent synthetic lethal combinations, and identified PIM1, a non-essential kinase. Here we demonstrate that PIM1 expression was elevated in TN tumors and was associated with poor prognosis in patients with hormone and HER2 receptor-negative tumors. Small molecule PIM kinase inhibitors halted the growth of human TN tumors with elevated MYC expression in patient-derived tumor xenograft (PDX) and MYC-driven transgenic breast cancer models by inhibiting oncogenic transcriptional activity of MYC while simultaneously restoring the function of the endogenous cell cycle inhibitor, p27. Our findings warrant clinical evaluation of PIM kinase inhibitors in patients with TN tumors that exhibit elevated MYC expression. PMID:27775705

  12. NFκB–Pim-1–Eomesodermin axis is critical for maintaining CD8 T-cell memory quality

    Science.gov (United States)

    Knudson, Karin M.; Saxena, Vikas; Altman, Amnon; Daniels, Mark A.; Teixeiro, Emma

    2017-01-01

    T-cell memory is critical for long-term immunity. However, the factors involved in maintaining the persistence, function, and phenotype of the memory pool are undefined. Eomesodermin (Eomes) is required for the establishment of the memory pool. Here, we show that in T cells transitioning to memory, the expression of high levels of Eomes is not constitutive but rather requires a continuum of cell-intrinsic NFκB signaling. Failure to maintain NFκB signals after the peak of the response led to impaired Eomes expression and a defect in the maintenance of CD8 T-cell memory. Strikingly, we found that antigen receptor [T-cell receptor (TCR)] signaling regulates this process through expression of the NFκB-dependent kinase proviral integration site for Moloney murine leukemia virus-1 (PIM-1), which in turn regulates NFκB and Eomes. T cells defective in TCR-dependent NFκB signaling were impaired in late expression of Pim-1, Eomes, and CD8 memory. These defects were rescued when TCR-dependent NFκB signaling was restored. We also found that NFκB–Pim-1 signals were required at memory to maintain memory CD8 T-cell longevity, effector function, and Eomes expression. Hence, an NFκB–Pim-1–Eomes axis regulates Eomes levels to maintain memory fitness. PMID:28193872

  13. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Chris [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Pajon, Anne [Wellcome Trust Genome Campus, Hinxton CB10 1SD (United Kingdom); Griffiths, Susanne L. [University of York, Heslington, York YO10 5DD (United Kingdom); Daniel, Ed [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Savitsky, Marc [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Lin, Bill [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Diprose, Jonathan M. [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Wilter da Silva, Alan [Wellcome Trust Genome Campus, Hinxton CB10 1SD (United Kingdom); Pilicheva, Katya [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Troshin, Peter [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Niekerk, Johannes van [University of Dundee, Dundee DD1 5EH, Scotland (United Kingdom); Isaacs, Neil [University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom); Naismith, James [University of St Andrews, St Andrews, Fife KY16 9ST, Scotland (United Kingdom); Nave, Colin; Blake, Richard [STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom); Wilson, Keith S. [University of York, Heslington, York YO10 5DD (United Kingdom); Stuart, David I. [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Henrick, Kim [Wellcome Trust Genome Campus, Hinxton CB10 1SD (United Kingdom); Esnouf, Robert M., E-mail: robert@strubi.ox.ac.uk [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom)

    2011-04-01

    The Protein Information Management System (PiMS) is described together with a discussion of how its features make it well suited to laboratories of all sizes. The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

  14. Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors.

    Science.gov (United States)

    Fan, Yin-Bo; Li, Kun; Huang, Min; Cao, Yu; Li, Ying; Jin, Shu-Yu; Liu, Wen-Bing; Wen, Jia-Chen; Liu, Dan; Zhao, Lin-Xiang

    2016-02-15

    A novel series of substituted pyrido[3,2-d]-1,2,3-triazines were designed and synthesized as Pim-1 inhibitors through scaffold hopping. Most of the derivatives showed potent in vitro Pim-1 inhibitory activities and anti-proliferative effects toward prostate cancer cells. Among them, 6b, 6h and 6m showed the best Pim-1 inhibitory activity with IC50 values of 0.69, 0.60 and 0.80 μM, respectively. Furthermore, compounds 6b, 6i, 6j and 6m showed strong inhibitory activity to human prostate cancer LNcap and PC-3 cell lines with IC50 values at low micromolar level. Structure-activity relationship analysis revealed that appropriate substitutions at C-6 positions contributed to the kinase inhibition and antiproliferative effects. Moreover, western blot assay suggested that 6j could decrease the levels of p-BAD and p-4E-BP1 in a dose-dependent manner in PC-3 cells. Docking studies showed that 3-N of the scaffold formed a hydrogen bond with Lys67, aromatic 4-aniline formed a key π-π stack with Phe49. Taken together, this study might provide the first sight for developing the pyrido[3,2-d]-1,2,3-triazine scaffold as novel Pim-1 inhibitors.

  15. Evaluation of the E mu-pim-1 transgenic mouse model for short-term carcinogenicity testing

    DEFF Research Database (Denmark)

    van Kreijl, C. F.; van Oordt, C. W. V.; Kroese, E. D.;

    1998-01-01

    . In the present article, the results from 2 recent short-term assays (with mitomycin C and x-rays) are briefly presented, together with a review of all 11 performed bioassays and their corresponding histopathologic and molecular data. The overall results allow the first evaluation of the E mu-pim-1 mouse model...

  16. Effect of bias voltage on TiAlSiN nanocomposite coatings deposited by HiPIMS

    Science.gov (United States)

    Ma, Quansheng; Li, Liuhe; Xu, Ye; Gu, Jiabin; Wang, Lei; Xu, Yi

    2017-01-01

    TiAlSiN nanocomposite coatings were deposited onto cemented carbide (WC-10 wt.%, Co) substrates by high power impulse magnetron sputtering (HiPIMS). The effect of substrate bias voltage on plasma discharge characterization of HiPIMS, element concentration, deposition rate, microstructure, surface/cross-sectional morphology, hardness and adhesion strength of coatings were studied. Compared with those deposited with direct current magnetic sputtering (DCMS), HiPIMS-deposited TiAlSiN coatings show improvements in some properties, including the surface roughness, the grain size, the hardness and adhesion strength, but a decrease in the deposition rate. When the bias voltage increases, the discharge current rose up from 118A to 165A. HiPIMS-deposited TiAlSiN coatings show a shift of the preferred crystallographic orientation from (220) to (200) and decreases in surface roughness from 14.1 nm down to 7.4 nm and grain size from 10.5 nm to 7.4 nm. Meanwhile, a change in crystal morphology from columnar to equiaxial and a grain refinement, as well as an increase of hardness from 30 GPa up to 42 GPa of those TiAlSiN coatings were observed with the increasing bias voltage and a decrease in adhesion strength from HF2 to HF5 of those coatings were revealed by indentation adhesion test.

  17. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.

    Science.gov (United States)

    Xie, Y; Xu, K; Dai, B; Guo, Z; Jiang, T; Chen, H; Qiu, Y

    2006-01-05

    Protein kinase Pim-1 has been implicated in the development of hematopoietic and prostatic malignancies. Here, we present the evidence that two isoforms, the 44 and 33 kDa Pim-1, are expressed in all human prostate cancer cell lines examined. The subcellular localization of human 44 kDa Pim-1 is primarily on the plasma membrane, while the 33 kDa isoform is present in both the cytosol and nucleus in PCA cells. The 44 kDa Pim-1 contains the proline-rich motif at the N-terminus and directly binds to the SH3 domain of tyrosine kinase Etk. Such interaction leads to the activation of Etk kinase activity possibly by competing with the tumor suppressor p53. This is corroborated by the fact that overexpression of the 44 kDa Pim-1 in prostate cancer cells confers the resistance to chemotherapeutic drugs. Our results suggest that these two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa Pim-1 may play a more prominent role in drug resistance in prostate cancer cells.

  18. Time-delay signatures in multi-transverse mode VCSELs subject to double-cavity polarization-rotated optical feedback

    Science.gov (United States)

    Lin, Hong; Khurram, Aliza; Hong, Yanhua

    2016-10-01

    Time delay (TD) signatures are studied experimentally in orthogonal polarizations and in individual transverse modes respectively in a VCSEL operating with three transverse modes. Different types of concealment of the TD signatures are observed when the polarization of feedback is rotated through large angles. Effects of feedback strength and external cavity length on the TD signatures are investigated. Weak feedback leads to better concealment of the TD signatures in the dominant polarization. When the round-trip time difference between the two external cavities is close to a half of the relaxation oscillation period, the TD signatures are minimized.

  19. Blockage of SSRP1/Ets-1/Pim-3 signalling enhances chemosensitivity of nasopharyngeal carcinoma to docetaxel in vitro.

    Science.gov (United States)

    Ai, Jingang; Li, Wei; Zeng, Ruifang; Xie, Zuozhong; Liu, Honghui; Hou, Minghua; Tan, Guolin

    2016-10-01

    Nasopharyngeal carcinoma (NPC) is a rare cancer in most parts of the world, but is prevalent in South China area. Besides, therapeutic outcome is still unsatisfactory for patients with refractory and relapsed NPC, even though receiving a second line of docetaxel-based chemotherapy. These reasons require a better understanding of mechanisms underlying the carcinogenesis, malignancy and chemoresistance. In the basis of our previous finding of SSRP1 over-expression in NPC cell lines, this study continuously discovered up-regulated Ets-1, phosphor-Ets-1 and Pim-3 in NPC tissues with immunohistochemistry assay and revealed a close correlation of these up-regulated proteins with NPC proliferation and invasion. Using gene-silencing technology followed by western blot and immunocytochemistry detections, SSRP1 was found to facilitate the translocation of phosphor-Ets-1 from cytoplasm to cell nucleus, but have marginal effect on Ets-1 expression and phosphorylation. Pim-3 was positively regulated by Ets-1. In NPC HNE-1 cells, all SSRP1, Ets-1 and Pim-3 knockdown diminished the cell proliferation, enhanced the apoptosis, as well as inhibited the autophagy, invasion and clonogenicity in the presence or absence of docetaxel at IC25. Exposure of HNE-1 cells to docetaxel (IC25) alone had modest effect on cell proliferation and autophagy, and was not as effective as docetaxel treatment after knockdown of SSRP1, Ets-1 or Pim-3 on induction of the apoptosis and on inhibition of the invasion and clonogenicity. Our data indicate that SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of NPC cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. Less is more: a project to reduce the number of PIMs (potentially inappropriate medications) on an elderly care ward

    Science.gov (United States)

    Aung, Tin Htun; Judith Beck, Adèle; Siese, Thomas; Berrisford, Richard

    2016-01-01

    Potentially inappropriate prescribing in healthcare of the elderly (HCE) is associated with avoidable adverse drug events (ADEs).1,2 A recent set of prescribing criteria has been designed and validated, called “Screening Tool of Older Persons' Prescriptions” (STOPP), to rationalise prescribing in hospitalised patients on HCE wards.1,3 The aim of this quality improvement project was to identify how many potentially inappropriate medications (PIMs) were prescribed on these wards, and remove them. This was executed by implementing a ward round checklist, which incorporated STOPP criteria, for the twice weekly, consultant led ward rounds. This quality improvement project was carried out over four months. In a pilot study, we identified eight inappropriate medical prescriptions among 148 medications (5.4% ) prescribed on one ward. After applying a checklist for a structured ward round, we reviewed the medications prescribed on that ward, and found 10 PIMs out of 192 (5.2% ). Utilising the increasingly recognised “plan, do, study, act” (PDSA) cycle,4 we implemented departmental teaching and meetings with other members of the multidisciplinary team, which raised awareness of PIMs among junior doctors, as well as involving our pharmacists in drug chart screening. During this process we continued with a further six cycles on a bi-weekly basis, and saw a gradual decrease in PIM to 1.5%. In conclusion, a structured ward round, facilitated by a checklist that included review of drug charts based on STOPP criteria, demonstrated a considerable reduction of PIMs. It would be interesting to apply this quality improvement project to non-HCE wards, including general surgical wards or adult psychiatry wards, as a means of not only reducing the effects of ADEs, but also the expenditure associated with unnecessary drug prescriptions, and the costs associated with additional care arising from associated ADEs. PMID:27096089

  1. A new design of robust H∞ sliding mode control for uncertain stochastic T-S fuzzy time-delay systems.

    Science.gov (United States)

    Gao, Qing; Feng, Gang; Xi, Zhiyu; Wang, Yong; Qiu, Jianbin

    2014-09-01

    In this paper, a novel dynamic sliding mode control scheme is proposed for a class of uncertain stochastic nonlinear time-delay systems represented by Takagi-Sugeno fuzzy models. The key advantage of the proposed scheme is that two very restrictive assumptions in most existing sliding mode control approaches for stochastic fuzzy systems have been removed. It is shown that the closed-loop control system trajectories can be driven onto the sliding surface in finite time almost certainly. It is also shown that the stochastic stability of the resulting sliding motion can be guaranteed in terms of linear matrix inequalities; moreover, the sliding-mode controller can be obtained simultaneously. Simulation results illustrating the advantages and effectiveness of the proposed approaches are also provided.

  2. Time-resolved particle image velocimetry measurements of the 3D single-mode Richtmyer-Meshkov instability

    Science.gov (United States)

    Xu, Qian; Krivets, Vitaliy V.; Sewell, Everest G.; Jacobs, Jeffrey W.

    2016-11-01

    A vertical shock tube is used to perform experiments on the single-mode three-dimensional Richtmyer-Meshkov Instability (RMI). The light gas (Air) and the heavy gas (SF6) enter from the top and the bottom of the shock tube driven section to form the interface. The initial perturbation is then generated by oscillating the gases vertically. Both gases are seeded with particles generated through vaporizing propylene glycol. An incident shock wave (M 1.2) impacts the interface to create an impulsive acceleration. The seeded particles are illuminated by a dual cavity 75W, Nd: YLF laser. Three high-speed CMOS cameras record time sequences of image pairs at a rate of 2 kHz. The initial perturbation used is that of a single, square-mode perturbation with either a single spike or a single bubble positioned at the center of the shock tube. The full time dependent velocity field is obtained allowing the determination of the circulation versus time. In addition, the evolution of time dependent amplitude is also determined. The results are compared with PIV measurements from previous two-dimensional single mode experiments along with PLIF measurements from previous three-dimensional single mode experiments.

  3. Output Tracking Using a Discrete-Time Sliding Mode Controller with Reduced-Order State-Error Estimation

    NARCIS (Netherlands)

    Monsees, G.; Scherpen, J.M.A.

    2001-01-01

    This paper presents a novel output-based, discrete-time, sliding mode controller design methodology. In order to reproduce an output target profile, feed-forward controllers yield an excellent performance, however their robustness against disturbances and parameter variations is limited. In this pap

  4. Discharge state transition and cathode fall thickness evolution during chromium HiPIMS discharge

    Science.gov (United States)

    Zuo, Xiao; Ke, Peiling; Chen, Rende; Li, Xiaowei; Odén, Magnus; Wang, Aiying

    2017-08-01

    The temporal evolutions of target voltage and current waveforms under different pulse voltage and working pressure conditions were studied during Cr high power impulse magnetron sputtering discharges. Target voltage and current characteristics demonstrated that when the pulse width was set as 200 μs, HiPIMS discharge went through a four-stage sequence during each pulse, Townsend discharge, glow discharge, afterglow, and pulse-off stages. A discharge state transition in the glow discharge stage happened at high pulse voltage and working pressure conditions. Furthermore, the dependence of reduced cathode fall thickness pdc on pulse voltage, working pressure, and normalized current density j/p2 was presented. It was found that gas rarefaction leads to a change of relationship between pdc and j/p2. A noticeable increase of the cathode fall thickness caused by gas rarefaction has been found.

  5. Scaling and laws of DC discharges as pointers for HiPIMS plasmas

    CERN Document Server

    Maszl, Christian; von Keudell, Achim; Störi, Herbert

    2015-01-01

    Scaling or smiliarity laws of plasmas are of interest if lab size plasma sources are to be scaled for industrial processes. Ideally, the discharge parameters of the scaled plasmas are predictable and the fundamental physical processes are unaltered. Naturally, there are limitations and ranges of validity. Scaling laws for direct current glow discharges are well known. If a well diagnosed discharge is scaled, the field strength in the positive column, the gas amplification and the normal current density can easily be estimated. For non-stationary high power discharges like high power impulse magnetron sputtering (HiPIMS) plasmas, scaling is not as straight forward. Here, one deals with a non-stationary complex system with strong changes in plasma chemistry and symmetry breaks during the pulses. Because of the huge parameter space no good parameters are available to define these kind of discharges unambiguous at the moment. In this contribution we will discuss the scaling laws for DC glow discharges briefly and...

  6. Biased HiPIMS technology for superconducting rf accelerating cavities coating

    CERN Document Server

    G. Rosaz, G.; Sonato, D.; Calatroni, S.; Ehiasarian, A.; Junginger, T.; Taborelli, M.

    2016-01-01

    In the last few years the interest of the thin film science and technology community on High Impulse Power Magnetron Sputtering (HIPIMS) coatings has steadily increased. HIPIMS literature shows that better thin film morphology, denser and smoother films can be achieved when compared with standard dc Magnetron Sputtering (dcMS) coating technology. Furthermore the capability of HIPIMS to produce a high quantity of ionized species can allow conformal coatings also for complex geometries. CERN already studied the possibility to use such a coating method for SRF accelerating cavities. Results are promising but not better from a RF point of view than dcMS coatings. Thanks to these results the next step is to go towards a biased HiPIMS approach. However the geometry of the cavities leads to complex changes in the coating setup in order to apply a bias voltage. Coating system tweaking and first superconducting properties of biased samples are presented.

  7. Scaling to Nanotechnology Limits with the PIMS Computer Architecture and a new Scaling Rule

    Energy Technology Data Exchange (ETDEWEB)

    Debenedictis, Erik P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    We describe a new approach to computing that moves towards the limits of nanotechnology using a newly formulated sc aling rule. This is in contrast to the current computer industry scali ng away from von Neumann's original computer at the rate of Moore's Law. We extend Moore's Law to 3D, which l eads generally to architectures that integrate logic and memory. To keep pow er dissipation cons tant through a 2D surface of the 3D structure requires using adiabatic principles. We call our newly proposed architecture Processor In Memory and Storage (PIMS). We propose a new computational model that integrates processing and memory into "tiles" that comprise logic, memory/storage, and communications functions. Since the programming model will be relatively stable as a system scales, programs repr esented by tiles could be executed in a PIMS system built with today's technology or could become the "schematic diagram" for implementation in an ultimate 3D nanotechnology of the future. We build a systems software approach that offers advantages over and above the technological and arch itectural advantages. Firs t, the algorithms may be more efficient in the conventional sens e of having fewer steps. Second, the algorithms may run with higher power efficiency per operation by being a better match for the adiabatic scaling ru le. The performance analysis based on demonstrated ideas in physical science suggests 80,000 x improvement in cost per operation for the (arguably) gene ral purpose function of emulating neurons in Deep Learning.

  8. Scaling to Nanotechnology Limits with the PIMS Computer Architecture and a new Scaling Rule.

    Energy Technology Data Exchange (ETDEWEB)

    Debenedictis, Erik

    2015-02-01

    We describe a new approach to computing that moves towards the limits of nanotechnology using a newly formulated sc aling rule. This is in contrast to the current computer industry scali ng away from von Neumann's original computer at the rate of Moore's Law. We extend Moore's Law to 3D, which l eads generally to architectures that integrate logic and memory. To keep pow er dissipation cons tant through a 2D surface of the 3D structure requires using adiabatic principles. We call our newly proposed architecture Processor In Memory and Storage (PIMS). We propose a new computational model that integrates processing and memory into "tiles" that comprise logic, memory/storage, and communications functions. Since the programming model will be relatively stable as a system scales, programs repr esented by tiles could be executed in a PIMS system built with today's technology or could become the "schematic diagram" for implementation in an ultimate 3D nanotechnology of the future. We build a systems software approach that offers advantages over and above the technological and arch itectural advantages. Firs t, the algorithms may be more efficient in the conventional sens e of having fewer steps. Second, the algorithms may run with higher power efficiency per operation by being a better match for the adiabatic scaling ru le. The performance analysis based on demonstrated ideas in physical science suggests 80,000 x improvement in cost per operation for the (arguably) gene ral purpose function of emulating neurons in Deep Learning.

  9. General demonstration of principal states of polarization and real-time monitoring of polarization mode dispersion in optical fibres

    Institute of Scientific and Technical Information of China (English)

    Dong Hui; Wu Chong-Qing; Fu Song-Nian

    2004-01-01

    We investigated the general properties of polarization effects in optical fibres and demonstrated the existence of socalled principal states of polarization (PSP), which mean the fixed points in mathematics, in different polarization effects,such as birefringence and polarization mode dispersion, by using fixed point theory. Furthermore, a time evolution vector is defined to describe the time evolution of polarization state in optical fibres, which is used to investigate the time evolution of polarization mode dispersion vector (PDV), including differential group delay and PSP. The experimentalresults of real-time monitoring of PDV by using this method are reported. To our knowledge, this is the first report on monitoring PSP evolution in optical fibres.

  10. Robust Stability for Nonlinear Systems with Time-Varying Delay and Uncertainties via the H∞ Quasi-Sliding Mode Control

    Directory of Open Access Journals (Sweden)

    Yi-You Hou

    2014-01-01

    Full Text Available This paper considers the problem of the robust stability for the nonlinear system with time-varying delay and parameters uncertainties. Based on the H∞ theorem, Lyapunov-Krasovskii theory, and linear matrix inequality (LMI optimization technique, the H∞ quasi-sliding mode controller and switching function are developed such that the nonlinear system is asymptotically stable in the quasi-sliding mode and satisfies the disturbance attenuation (H∞-norm performance. The effectiveness and accuracy of the proposed methods are shown in numerical simulations.

  11. Time-convolutionless mode-coupling theory near the glasstransition: Numerical solutions for the Percus-Yevick model

    Science.gov (United States)

    Kimura, Y.; Tokuyama, M.

    2016-05-01

    The full numerical solutions of the time-convolutionless mode-coupling theory (TMCT) equation recently proposed by Tokuyama are compared with those of the ideal mode-coupling theory (MCT) equation based on the Percus-Yevick static structure factor for hard spheres qualitatively and quantitatively. The ergodic to non-ergodic transition at the critical volume fraction φ_c predicted by MCT is also shown to occur even for TMCT. Thus, φ_c of TMCT is shown to be much higher than that of MCT. The dynamics of coherent-intermediate scattering functions and their two-step relaxation process in a β stage are also discussed.

  12. Real Time Cardan Shaft State Estimation of High-Speed Train Based on Ensemble Empirical Mode Decomposition

    OpenAIRE

    Cai Yi; Jianhui Lin; Tengda Ruan; Yanping Li

    2015-01-01

    Due to the special location and structure of transmission system on high-speed train named CRH5, dynamic unbalance state of the cardan shaft will pose a threat to the train servicing safety, so effective methods that test the cardan shaft operating information and estimate the performance state in real time are needed. In this study a useful estimation method based on ensemble empirical mode decomposition (EEMD) is presented. By using this method, time-frequency characteristic of cardan shaft...

  13. A time resolution study with a plastic scintillator read out by a Geiger-mode Avalanche Photodiode

    Science.gov (United States)

    Stoykov, A.; Scheuermann, R.; Sedlak, K.

    2012-12-01

    In this work we attempt to establish the best time resolution attainable with a scintillation counter consisting of a plastic scintillator read out by a Geiger-mode Avalanche Photodiode. The measured time resolution is inversely proportional to the square root of the energy deposited in the scintillator, and scales to σ=18 ps at 1 MeV. This result competes with the best ones reported for photomultiplier tubes.

  14. A time resolution study with a plastic scintillator read out by a Geiger-mode Avalanche Photodiode

    Energy Technology Data Exchange (ETDEWEB)

    Stoykov, A., E-mail: alexey.stoykov@psi.ch [Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Scheuermann, R.; Sedlak, K. [Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland)

    2012-12-11

    In this work we attempt to establish the best time resolution attainable with a scintillation counter consisting of a plastic scintillator read out by a Geiger-mode Avalanche Photodiode. The measured time resolution is inversely proportional to the square root of the energy deposited in the scintillator, and scales to {sigma}=18ps at 1 MeV. This result competes with the best ones reported for photomultiplier tubes.

  15. A time-resolution study with a plastic scintillator read out by a Geiger-mode Avalanche Photodiode

    CERN Document Server

    Stoykov, A; Sedlak, K

    2011-01-01

    In this work we attempt to establish the best time resolution attainable with a scintillation counter consisting of a plastic scintillator read out by a Geiger-mode Avalanche Photodiode. The measured time resolution is inversely proportional to the square root of the energy deposited in the scintillator, and scales to 18ps (sigma) at 1MeV. This result competes with the best ones reported for photomultiplier tubes.

  16. Space-time evolution of whistler mode wavegrowth in the magnetosphere

    Science.gov (United States)

    Carlson, C. R.; Helliwell, R. A.; Inan, U. S.

    1990-01-01

    The modeling and simulation of the growth of ducted single-frequency whistler-mode waves through cyclotron resonance with radiation belt electrons are considered. The Siple transmitter and a geomagnetically conjugate receiving station are used for the present study. The results can be applied to slowly varying frequency signals and to broadband 'noiselike' signals.

  17. Mode-observability degree in discrete-time switching linear systems

    NARCIS (Netherlands)

    Baglietto, M.; Battistelli, G.; Tesi, P.

    2014-01-01

    In this paper, we consider the problem of identifying the active mode of a switching linear system from data sequences of a finite length. The results combine elements from canonical correlation analysis and subspace projection methods. In addition to providing insight into the geometric meaning of

  18. Mixed-mode oscillations in a three time-scale model for the dopaminergic neuron.

    NARCIS (Netherlands)

    Krupa, M.; Popovic, N.; Kopell, N.; Rotstein, H.G.

    2008-01-01

    Mixed-mode dynamics is a complex type of dynamical behavior that has been observed both numerically and experimentally in numerous prototypical systems in the natural sciences. The compartmental Wilson-Callaway model for the dopaminergic neuron is an example of a system that exhibits a wide variety

  19. Stable parity-time-symmetric nonlinear modes and excitations in a derivative nonlinear Schrödinger equation

    Science.gov (United States)

    Chen, Yong; Yan, Zhenya

    2017-01-01

    The effect of derivative nonlinearity and parity-time-symmetric (PT -symmetric) potentials on the wave propagation dynamics is explored in the derivative nonlinear Schrödinger equation, where the physically interesting Scarf-II and harmonic-Hermite-Gaussian potentials are chosen. We study numerically the regions of unbroken and broken linear PT -symmetric phases and find some stable bright solitons of this model in a wide range of potential parameters even though the corresponding linear PT -symmetric phases are broken. The semielastic interactions between particular bright solitons and exotic incident waves are illustrated such that we find that particular nonlinear modes almost keep their shapes after interactions even if the exotic incident waves have evidently been changed. Moreover, we exert the adiabatic switching on PT -symmetric potential parameters such that a stable nonlinear mode with the unbroken linear PT -symmetric phase can be excited to another stable nonlinear mode belonging to the broken linear PT -symmetric phase.

  20. Use of Time-Frequency Analysis and Neural Networks for Mode Identification in a Wireless Software-Defined Radio Approach

    Directory of Open Access Journals (Sweden)

    Matteo Gandetto

    2004-09-01

    Full Text Available The use of time-frequency distributions is proposed as a nonlinear signal processing technique that is combined with a pattern recognition approach to identify superimposed transmission modes in a reconfigurable wireless terminal based on software-defined radio techniques. In particular, a software-defined radio receiver is described aiming at the identification of two coexistent communication modes: frequency hopping code division multiple access and direct sequence code division multiple access. As a case study, two standards, based on the previous modes and operating in the same band (industrial, scientific, and medical, are considered: IEEE WLAN 802.11b (direct sequence and Bluetooth (frequency hopping. Neural classifiers are used to obtain identification results. A comparison between two different neural classifiers is made in terms of relative error frequency.

  1. Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

    Science.gov (United States)

    Letribot, Boris; Akué-Gédu, Rufine; Santio, Niina M; El-Ghozzi, Malika; Avignant, Daniel; Cisnetti, Federico; Koskinen, Päivi J; Gautier, Arnaud; Anizon, Fabrice; Moreau, Pascale

    2012-04-01

    We have previously demonstrated that pyrrolo[2,3-a]carbazole-3-carbaldehydes are potent Pim kinase inhibitors with in vitro antiproliferative activities. In the present study, we report the synthesis of new pyrrolocarbazoles substituted at the N-10 position. When their ability to inhibit Pim kinase activities were evaluated in in vitro assays, we observed that this nitrogen atom can be substituted without loss of Pim-1 and Pim-3 inhibitory potencies. Moreover, when we added a fluorescent dansyl group (compound 13), we were able to show that 13 penetrates the plasma membrane and enters the cytoplasm. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  2. Adaptive backstepping sliding mode control of flexible ball screw drives with time-varying parametric uncertainties and disturbances.

    Science.gov (United States)

    Dong, Liang; Tang, Wen Cheng

    2014-01-01

    This paper presents a method to model and design servo controllers for flexible ball screw drives with dynamic variations. A mathematical model describing the structural flexibility of the ball screw drive containing time-varying uncertainties and disturbances with unknown bounds is proposed. A mode-compensating adaptive backstepping sliding mode controller is designed to suppress the vibration. The time-varying uncertainties and disturbances represented in finite-term Fourier series can be estimated by updating the Fourier coefficients through function approximation technique. Adaptive laws are obtained from Lyapunov approach to guarantee the convergence and stability of the closed loop system. The simulation results indicate that the tracking accuracy is improved considerably with the proposed scheme when the time-varying parametric uncertainties and disturbances exist.

  3. Rotation Modes Stability Analysis and Phase Compensation for Magnetically Suspended Flywheel Systems with Cross Feedback Controller and Time Delay

    Directory of Open Access Journals (Sweden)

    Yuan Ren

    2016-01-01

    Full Text Available This paper analyzes the effects of time delay on the stability of the rotation modes for the magnetically suspended flywheel (MSFW with strong gyroscopic effects. A multi-input multioutput system is converted into a single-input single-output control system with complex coefficient by variable reconstruction, and the stability equivalence of the systems before and after variable reconstruction is proven. For the rotation modes, the stability limits and corresponding vibration frequencies are found as a function of nondimensional magnetic stiffness and damping and nondimensional parameters of rotor speed and time delay. Additionally, the relationship between cross feedback control system stability and time delay is investigated. And an effective phase compensation method based on cross-channel is further presented. Simulation and experimental results are presented to demonstrate the correctness of the stability analysis method and the superiority of the phase compensation strategy.

  4. Time-domain study of acoustic pulse propagation in an ocean waveguide using a new normal mode model

    Science.gov (United States)

    Sidorovskaia, Natalia Anatol'evna

    1997-11-01

    This study is focused on issues of numerical modeling of sound propagation in diverse ocean waveguides. A new normal mode acoustical model (Shallow Water Acoustic Mode Propagation-SWAMP) has been developed. The algorithm for obtaining the vertical modal solution is based on a warping matrix transformation of the solution of an isovelocity (reference) waveguide to one of arbitrary velocity profile. An efficient mode coupling scheme with an adaptive step-size in range has been implemented for range-dependent environments. The new algorithm allows fairly arbitrary ocean layering and readily works at high frequency. An important advantage of the new procedure is that vertical modal eigenfunctions can easily be transformed to a spherical representation suitable for coupling in object scattering problems. Benchmarking results of the new code against established acoustic models based on parabolic equation and existing normal mode approaches show good agreement for range-independent and up-slope and down-slope bathymetries and a very competitive calculation speed. Broad-band pulse propagation in deep and shallow water with double (surface and bottom) ducts has been modeled using the new normal mode model for a variety of ocean waveguide parameters and different frequency bands. The surface duct generates a series of the surface-duct-trapped- modes, which form amplitude-modulated precursors in the far field pulse response. It has been found that the arrival times of the precursors could not be explained by the conventional concept of group velocity so that a more general principle based on the rate of energy transfer has been used. The Airy function solution was found to explain the amplitude modulation of the precursors. It has been learned from the numerical simulation that for a range-independent environment the time separation between precursors is fixed and any variations from this have been a result of range-dependence and mode coupling in the model. The time

  5. Extraction of Gold(III) from Hydrochloric Acid Solutions with a PVC-based Polymer Inclusion Membrane (PIM) Containing Cyphos® IL 104

    OpenAIRE

    2015-01-01

    Abstract: Poly(vinyl chloride) (PVC) based polymer inclusion membranes (PIMs), with different concentrations of Cyphos® IL 104 as the membrane extractant/carrier, were studied for their ability to extract Au(III) from hydrochloric acid solutions. Some of the PIMs also contained one of the following plasticizers or modifiers: 2-nitrophenyloctyl ether, dioctylphthalate, 1-dodecanol, 1-tetradecanol, or tri(2-ethylhexyl) phosphate. The best performance, in terms of extraction rate and amount of A...

  6. Improving B mode ultrasound evaluation of breast lesions with real-time ultrasound elastography--a clinical approach.

    Science.gov (United States)

    Tan, S M; Teh, H S; Mancer, J F Kent; Poh, W T

    2008-06-01

    Ultrasound elastography using the extended combined auto-correlation method of tissue elasticity allows for real-time strain image visualisation using a free-hand probe with concurrent conventional B mode imaging. Four hundred and fifteen consecutive women with 550 breast lesions confirmed on B mode ultrasound were assessed with elastography using the elasticity score. There were 119 malignant and 431 benign lesions. The elastography sensitivity was 78.0%, specificity was 98.5% and overall accuracy was 93.8%. The median score for malignancy was 5 and that for benign lesions was 2. There was good correlation with B mode BIRADS category. 98.6% of lesions with an elasticity score of 2 or below (95%CI=96.8-99.4) were benign. BIRADS 3 lesions with an elasticity score of 2 or below may be re-classified as BIRADS 2 lesions. We found that 15.3% of BIRADS 2 and 3 lesions with an elasticity score of 3 were malignant. Real-time ultrasound elastography is user-friendly with a high accuracy rate, thereby improving B mode ultrasound assessment.

  7. Enhancing dominant modes in nonstationary time series by means of the symbolic resonance analysis.

    Science.gov (United States)

    beim Graben, Peter; Drenhaus, Heiner; Brehm, Eva; Rhode, Bela; Saddy, Douglas; Frisch, Stefan

    2007-12-01

    We present the symbolic resonance analysis (SRA) as a viable method for addressing the problem of enhancing a weakly dominant mode in a mixture of impulse responses obtained from a nonlinear dynamical system. We demonstrate this using results from a numerical simulation with Duffing oscillators in different domains of their parameter space, and by analyzing event-related brain potentials (ERPs) from a language processing experiment in German as a representative application. In this paradigm, the averaged ERPs exhibit an N400 followed by a sentence final negativity. Contemporary sentence processing models predict a late positivity (P600) as well. We show that the SRA is able to unveil the P600 evoked by the critical stimuli as a weakly dominant mode from the covering sentence final negativity.

  8. Validation of frequency and mode extraction calculations from time-domain simulations of accelerator cavities

    CERN Document Server

    Austin, T M; Ovtchinnikov, S; Werner, G R; Bellantoni, L

    2010-01-01

    The recently developed frequency extraction algorithm [G.R. Werner and J.R. Cary, J. Comp. Phys. 227, 5200 (2008)] that enables a simple FDTD algorithm to be transformed into an efficient eigenmode solver is applied to a realistic accelerator cavity modeled with embedded boundaries and Richardson extrapolation. Previously, the frequency extraction method was shown to be capable of distinguishing M degenerate modes by running M different simulations and to permit mode extraction with minimal post-processing effort that only requires solving a small eigenvalue problem. Realistic calculations for an accelerator cavity are presented in this work to establish the validity of the method for realistic modeling scenarios and to illustrate the complexities of the computational validation process. The method is found to be able to extract the frequencies with error that is less than a part in 10^5. The corrected experimental and computed values differ by about one parts in 10^$, which is accounted for (in largest part)...

  9. Enhancing dominant modes in nonstationary time series by means of the symbolic resonance analysis

    Science.gov (United States)

    beim Graben, Peter; Drenhaus, Heiner; Brehm, Eva; Rhode, Bela; Saddy, Douglas; Frisch, Stefan

    2007-12-01

    We present the symbolic resonance analysis (SRA) as a viable method for addressing the problem of enhancing a weakly dominant mode in a mixture of impulse responses obtained from a nonlinear dynamical system. We demonstrate this using results from a numerical simulation with Duffing oscillators in different domains of their parameter space, and by analyzing event-related brain potentials (ERPs) from a language processing experiment in German as a representative application. In this paradigm, the averaged ERPs exhibit an N400 followed by a sentence final negativity. Contemporary sentence processing models predict a late positivity (P600) as well. We show that the SRA is able to unveil the P600 evoked by the critical stimuli as a weakly dominant mode from the covering sentence final negativity.

  10. Ethylene/ethane permeation, diffusion and gas sorption properties of carbon molecular sieve membranes derived from the prototype ladder polymer of intrinsic microporosity (PIM-1)

    KAUST Repository

    Salinas, Octavio

    2016-01-05

    Fine-tuning the microporosity of PIM-1 by heat treatment was applied to develop a suitable carbon molecular sieve membrane for ethylene/ethane separation. Pristine PIM-1 films were heated from 400 to 800 °C under inert N2 atmosphere (< 2 ppm O2). At 400 °C, PIM-1 self-cross-linked and developed polar carbonyl and hydroxyl groups due to partial dioxane splitting in the polymer backbone. Significant degradation occurred at 600 °C due to carbonization of PIM-1 and resulted in 30% increase in cumulative surface area compared to its cross-linked predecessor. In addition, PIM-1-based CMS developed smaller ultramicropores with increasing pyrolysis temperature, which enhanced their molecular sieving capability by restricted diffusion of ethylene and ethane through the matrix due to microstructural carbon densification. Consequently, the pure-gas ethylene permeability (measured at 35 °C and 2 bar) decreased from 1600 Barrer for the pristine PIM-1 to 1.3 Barrer for the amorphous carbon generated at 800 °C, whereas the ethylene/ethane pure-gas selectivity increased significantly from 1.8 to 13.

  11. Material Characterization of Strontium Ferrite Powders for Producing Sintered Magnets by Ceramic Injection Molding (MagnetPIM

    Directory of Open Access Journals (Sweden)

    Dietmar Drummer

    2014-01-01

    Full Text Available For this study, different strontium ferrite powders were mixed with a filling ratio of about 60 vol% in a binder system and formed into green compacts. During the process of injection molding, a magnetic field was generated in the tool via a magnetic coil, which enables magnetization and orientation of the ceramic particles. All powders were successfully processed by MagnetPIM. The investigations identified that it is impossible to extrapolate from the magnetic properties of a green compact to the magnetic properties of a sintered part. It became obvious, though, that, when producing very strong magnetic parts by MagnetPIM, the best results can be obtained by using powders with small particle sizes.

  12. Gas transport behavior of mixed-matrix membranes composed of silica nanoparticles in a polymer of intrinsic microporosity (PIM-1)

    KAUST Repository

    Ahn, Juhyeon

    2010-01-01

    Recently, high-free volume, glassy ladder-type polymers, referred to as polymers of intrinsic microporosity (PIM), have been developed and their reported gas transport performance exceeded the Robeson upper bound trade-off for O2/N2 and CO2/CH4. The present work reports the gas transport behavior of PIM-1/silica nanocomposite membranes. The changes in free volume, as well as the presence and volume of the void cavities, were investigated by analyzing the density, thermal stability, and nano-structural morphology. The enhancement in gas permeability (e.g., He, H2, O2, N2, and CO2) with increasing filler content shows that the trend is related to the true silica volume and void volume fraction. Crown Copyright © 2009.

  13. On stabilization of stochastic Cohen-Grossberg neural networks with mode-dependent mixed time-delays and Markovian switching.

    Science.gov (United States)

    Zheng, Cheng-De; Shan, Qi-He; Zhang, Huaguang; Wang, Zhanshan

    2013-05-01

    The globally exponential stabilization problem is investigated for a general class of stochastic Cohen-Grossberg neural networks with both Markovian jumping parameters and mixed mode-dependent time-delays. The mixed time-delays consist of both discrete and distributed delays. This paper aims to design a memoryless state feedback controller such that the closed-loop system is stochastically exponentially stable in the mean square sense. By introducing a new Lyapunov-Krasovskii functional that accounts for the mode-dependent mixed delays, stochastic analysis is conducted in order to derive delay-dependent criteria for the exponential stabilization problem. Three numerical examples are carried out to demonstrate the feasibility of our delay-dependent stabilization criteria.

  14. Robust pre-specified time synchronization of chaotic systems by employing time-varying switching surfaces in the sliding mode control scheme

    Science.gov (United States)

    Khanzadeh, Alireza; Pourgholi, Mahdi

    2016-08-01

    In the conventional chaos synchronization methods, the time at which two chaotic systems are synchronized, is usually unknown and depends on initial conditions. In this work based on Lyapunov stability theory a sliding mode controller with time-varying switching surfaces is proposed to achieve chaos synchronization at a pre-specified time for the first time. The proposed controller is able to synchronize chaotic systems precisely at any time when we want. Moreover, by choosing the time-varying switching surfaces in a way that the reaching phase is eliminated, the synchronization becomes robust to uncertainties and exogenous disturbances. Simulation results are presented to show the effectiveness of the proposed method of stabilizing and synchronizing chaotic systems with complete robustness to uncertainty and disturbances exactly at a pre-specified time.

  15. Finite-time H∞ control for a class of Markovian jump systems with mode-dependent time-varying delays via new Lyapunov functionals.

    Science.gov (United States)

    Cheng, Jun; Zhu, Hong; Zhong, Shouming; Zeng, Yong; Dong, Xiucheng

    2013-11-01

    This paper is concerned with the problem of finite-time H∞ control for a class of Markovian jump systems with mode-dependent time-varying delays via new Lyapunov functionals. In order to reduce conservatism, a new Lyapunov-Krasovskii functional is constructed. Based on the derived condition, the reliable H∞ control problem is solved, and the system trajectory stays within a prescribed bound during a specified time interval. Finally, numerical examples are given to demonstrate the proposed approach is more effective than some existing ones.

  16. Time-Distance Helioseismology with f Modes as a Method for Measurement of Near-Surface Flows

    Science.gov (United States)

    Duvall, Thomas L., Jr.; Gizon, Laurent

    1999-01-01

    Travel times measured for the f mode have been used to study flows near the solar surface in conjunction with simultaneous measurements of the magnetic field. Previous flow measurements of doppler surface rotation, small magnetic feature rotation, supergranular pattern rotation, and surface meridional circulation have been confirmed. In addition, the flow in supergranules due to Coriolis forces has been measured. The spatial and temporal power spectra for a six-day observing sequence has been measured.

  17. A reference station-based GNSS computing mode to support unified precise point positioning and real-time kinematic services

    Science.gov (United States)

    Feng, Yanming; Gu, Shengfeng; Shi, Chuang; Rizos, Chris

    2013-11-01

    Currently, the GNSS computing modes are of two classes: network-based data processing and user receiver-based processing. A GNSS reference receiver station essentially contributes raw measurement data in either the RINEX file format or as real-time data streams in the RTCM format. Very little computation is carried out by the reference station. The existing network-based processing modes, regardless of whether they are executed in real-time or post-processed modes, are centralised or sequential. This paper describes a distributed GNSS computing framework that incorporates three GNSS modes: reference station-based, user receiver-based and network-based data processing. Raw data streams from each GNSS reference receiver station are processed in a distributed manner, i.e., either at the station itself or at a hosting data server/processor, to generate station-based solutions, or reference receiver-specific parameters. These may include precise receiver clock, zenith tropospheric delay, differential code biases, ambiguity parameters, ionospheric delays, as well as line-of-sight information such as azimuth and elevation angles. Covariance information for estimated parameters may also be optionally provided. In such a mode the nearby precise point positioning (PPP) or real-time kinematic (RTK) users can directly use the corrections from all or some of the stations for real-time precise positioning via a data server. At the user receiver, PPP and RTK techniques are unified under the same observation models, and the distinction is how the user receiver software deals with corrections from the reference station solutions and the ambiguity estimation in the observation equations. Numerical tests demonstrate good convergence behaviour for differential code bias and ambiguity estimates derived individually with single reference stations. With station-based solutions from three reference stations within distances of 22-103 km the user receiver positioning results, with various

  18. Material Characterization of Strontium Ferrite Powders for Producing Sintered Magnets by Ceramic Injection Molding (MagnetPIM)

    OpenAIRE

    Dietmar Drummer; Susanne Messingschlager

    2014-01-01

    For this study, different strontium ferrite powders were mixed with a filling ratio of about 60 vol% in a binder system and formed into green compacts. During the process of injection molding, a magnetic field was generated in the tool via a magnetic coil, which enables magnetization and orientation of the ceramic particles. All powders were successfully processed by MagnetPIM. The investigations identified that it is impossible to extrapolate from the magnetic properties of a green compact t...

  19. Timing the provision of a pregnancy decision-aid: temporal patterns of preference for mode of birth during pregnancy.

    Science.gov (United States)

    Shorten, Allison; Shorten, Brett

    2014-10-01

    To help identify the optimal timing for provision of pregnancy decision-aids, this paper examines temporal patterns in women's preference for mode of birth after previous cesarean, prior to a decision-aid intervention. Pregnant women (n=212) with one prior cesarean responded to surveys regarding their preference for elective repeat cesarean delivery (ERCD) or trial of labor (TOL) at 12-18 weeks and again at 28 weeks gestation. Patterns of adherence or change in preference were examined. Women's preferences for birth were not set in early pregnancy. There was evidence of increasing uncertainty about preferred mode of birth during the first two trimesters of pregnancy (McNemar value=4.41, p=0.04), decrease in preference for TOL (McNemar value=3.79, p=0.05) and stability in preference for ERCD (McNemar value=0.31, p=0.58). Adherence to early pregnancy choice was associated with previous birth experience, maternal country of birth, emotional state and hospital site. Women's growing uncertainty about mode of birth prior to 28 weeks indicates potential readiness for a decision-aid earlier in pregnancy. Pregnancy decision-aids affecting mode of birth could be provided early in pregnancy to increase women's opportunity to improve knowledge, clarify personal values and reduce decision uncertainty. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. A multi-component and multi-failure mode inspection model based on the delay time concept

    Energy Technology Data Exchange (ETDEWEB)

    Wang Wenbin, E-mail: w.wang@salford.ac.u [Salford Business School, University of Salford, Salford, M5 4WT (United Kingdom); PHM Centre of City University of Hong Kong (Hong Kong); Banjevic, Dragan [Department of Mechanical and Industrial Engineering, University of Toronto (Canada); Pecht, Michael [PHM Centre of City University of Hong Kong (Hong Kong); CALCE Electronic Products and Systems, University of Maryland, College Park, MD 20742 (United States)

    2010-08-15

    The delay time concept and the techniques developed for modelling and optimising plant inspection practices have been reported in many papers and case studies. For a system comprised of many components and subject to many different failure modes, one of the most convenient ways to model the inspection and failure processes is to use a stochastic point process for defect arrivals and a common delay time distribution for the duration between defect the arrival and failure of all defects. This is an approximation, but has been proven to be valid when the number of components is large. However, for a system with just a few key components and subject to few major failure modes, the approximation may be poor. In this paper, a model is developed to address this situation, where each component and failure mode is modelled individually and then pooled together to form the system inspection model. Since inspections are usually scheduled for the whole system rather than individual components, we then formulate the inspection model when the time to the next inspection from the point of a component failure renewal is random. This imposes some complication to the model, and an asymptotic solution was found. Simulation algorithms have also been proposed as a comparison to the analytical results. A numerical example is presented to demonstrate the model.

  1. Prognostic value of cardiac time intervals measured by tissue Doppler imaging M-mode in the general population

    DEFF Research Database (Denmark)

    Biering-Sørensen, Tor; Mogelvang, Rasmus; Jensen, Jan Skov

    2015-01-01

    OBJECTIVE: Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to estimate the cardiac time intervals. The aim was to evaluate the usability of the cardiac time intervals in predicting major cardiovascular events (MACE) in the general population. METHODS......: In a large prospective community-based study, cardiac function was evaluated in 1915 participants by both conventional echocardiography and TDI. The cardiac time intervals, including the isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT) and ejection time (ET), were obtained by TDI M...... echocardiographic parameters resulted in a significant increase in the c-statistics (0.76 vs 0.75 ptime intervals that include...

  2. Fully 3D list-mode time-of-flight PET image reconstruction on GPUs using CUDA.

    Science.gov (United States)

    Cui, Jing-Yu; Pratx, Guillem; Prevrhal, Sven; Levin, Craig S

    2011-12-01

    List-mode processing is an efficient way of dealing with the sparse nature of positron emission tomography (PET) data sets and is the processing method of choice for time-of-flight (ToF) PET image reconstruction. However, the massive amount of computation involved in forward projection and backprojection limits the application of list-mode reconstruction in practice, and makes it challenging to incorporate accurate system modeling. The authors present a novel formulation for computing line projection operations on graphics processing units (GPUs) using the compute unified device architecture (CUDA) framework, and apply the formulation to list-mode ordered-subsets expectation maximization (OSEM) image reconstruction. Our method overcomes well-known GPU challenges such as divergence of compute threads, limited bandwidth of global memory, and limited size of shared memory, while exploiting GPU capabilities such as fast access to shared memory and efficient linear interpolation of texture memory. Execution time comparison and image quality analysis of the GPU-CUDA method and the central processing unit (CPU) method are performed on several data sets acquired on a preclinical scanner and a clinical ToF scanner. When applied to line projection operations for non-ToF list-mode PET, this new GPU-CUDA method is >200 times faster than a single-threaded reference CPU implementation. For ToF reconstruction, we exploit a ToF-specific optimization to improve the efficiency of our parallel processing method, resulting in GPU reconstruction >300 times faster than the CPU counterpart. For a typical whole-body scan with 75 × 75 × 26 image matrix, 40.7 million LORs, 33 subsets, and 3 iterations, the overall processing time is 7.7 s for GPU and 42 min for a single-threaded CPU. Image quality and accuracy are preserved for multiple imaging configurations and reconstruction parameters, with normalized root mean squared (RMS) deviation less than 1% between CPU and GPU

  3. Quasinormal Modes and Thermodynamics of Linearly Charged BTZ Black holes in Massive Gravity in (Anti)de Sitter Space Time

    CERN Document Server

    Prasia, P

    2016-01-01

    In this work we study the Quasi Normal Modes(QNMs) under massless scalar perturbations and the thermodynamics of linearly charged BTZ black holes in massive gravity in the (Anti)de Sitter((A)dS) space time. It is found that the behavior of QNMs changes with the massive parameter and also with the charge of the black hole. The thermodynamics of such black holes in the (A)dS space time is also analyzed in detail. The behavior of specific heat with temperature for such black holes gives an indication of a phase transition that depends on the massive parameter and also on the charge of the black hole.

  4. A new minimum-time control law for a one-mode model of a flexible slewing structure

    Science.gov (United States)

    Barbieri, Enrique; Ozguner, Umit

    1993-01-01

    We describe the construction of a new minimum-time control law for a single-axis, undamped, one-mode model of a flexible slewing structure. The set of necessary and sufficient conditions for optimality are developed using phase-plane techniques, and are given in terms of the vibration frequencies and the rigid-body states. This effectively provides the switching hypersurface in four-dimensional space. The resulting control strategy has the advantage that can be implemented on-line since no a priori computation of switching times is required.

  5. Low-timing-jitter high-power mode-locked 1063 nm Nd:GdVO₄ master oscillator power amplifier.

    Science.gov (United States)

    Wang, Zhi-min; Zhang, Feng-feng; Zuo, Jun-wei; Yang, Jing; Yuan, Lei; Peng, Qin-jun; Cui, Da-fu; Xu, Zu-yan

    2015-10-01

    A low-timing-jitter high-power semiconductor saturable absorber mirror mode-locked picosecond (ps) 1063 nm Nd:GdVO4 master oscillator power amplifier is presented. Using a single-pass Nd:GdVO4 amplifier, an amplified laser with 21.5 W output power and 8.3 ps pulsewidth was achieved at 250 MHz repetition rate. Employing a servo control, an average RMS timing jitter of ∼222  fs was realized. This laser can be used as a drive laser for photocathode injectors in free-electron lasers.

  6. Attosecond timing jitter pulse trains from semiconductor saturable absorber mode-locked Cr:LiSAF lasers

    OpenAIRE

    Sennaroğlu, Alphan; Li, Duo; Demirbaş, Ümit; Benedick, Andrew; Fujimoto, James G.; Kaertner, Franz X.

    2012-01-01

    The timing jitter of optical pulse trains from diode-pumped, semiconductor saturable absorber mode-locked femtosecond Cr:LiSAF lasers is characterized by a single-crystal balanced optical cross-correlator with an equivalent sensitivity in phase noise of -235 dBc/Hz. The RMS timing jitter is 30 attoseconds integrated from 10 kHz to 50 MHz, the Nyquist frequency of the 100 MHz repetition rate oscillator. The AM-to-PM conversion induced excess phase noise is calculated and compared with experime...

  7. Strategies to reduce the configuration time for a powered knee and ankle prosthesis across multiple ambulation modes.

    Science.gov (United States)

    Simon, Ann M; Fey, Nicholas P; Finucane, Suzanne B; Lipschutz, Robert D; Hargrove, Levi J

    2013-06-01

    Recently developed powered lower limb prostheses allow users to more closely mimic the kinematics and kinetics of non-amputee gait. However, configuring such a device, in particular a combined powered knee and ankle, for individuals with a transfemoral amputation is challenging. Previous attempts have relied on empirical tuning of all control parameters. This paper describes modified stance phase control strategies - which mimic the behavior of biological joints or depend on the instantaneous loads within the prosthesis - developed to reduce the number of control parameters that require individual tuning. Three individuals with unilateral transfemoral amputations walked with a powered knee and ankle prosthesis across five ambulation modes (level ground walking, ramp ascent/descent, and stair ascent/descent). Starting with a nominal set of impedance parameters, the modified control strategies were applied and the devices were individually tuned such that all subjects achieved comfortable and safe ambulation. The control strategies drastically reduced the number of independent parameters that needed to be tuned for each subject (i.e., to 21 parameters instead of a possible 140 or approximately 4 parameters per mode) while relative amplitudes and timing of kinematic and kinetic data remained similar to those previously reported and to those of non-amputee subjects. Reducing the time necessary to configure a powered device across multiple ambulation modes may allow users to more quickly realize the benefits such powered devices can provide.

  8. Robust H∞ Control for Nonlinear Uncertain Switched Descriptor Systems with Time Delay and Nonlinear Input: A Sliding Mode Approach

    Directory of Open Access Journals (Sweden)

    Mourad Kchaou

    2017-01-01

    Full Text Available This paper addresses the problem of sliding mode control (SMC design for a class of uncertain switched descriptor systems with state delay and nonlinear input. An integral sliding function is designed and an adaptive sliding mode controller for the reaching motion is then synthesised such that the trajectories of the resulting closed-loop system can be driven onto a prescribed sliding surface and maintained there for all subsequent times. Moreover, based on a new Lyapunov-Krasovskii functional, a delay-dependent sufficient condition is established such that the admissibility as well as the H∞ performance requirement of the sliding mode dynamics can be guaranteed in the presence of time delay, external disturbances, and nonlinear input which comprises dead-zones and/or sector nonlinearities. The major contributions of this paper of this approach include (i the closed-loop system exhibiting strong robustness against nonlinear dynamics and (ii the control scheme enjoying the chattering-free characteristic. Finally, two representative examples are given to illustrate the theoretical developments.

  9. Determination of the action modes of cellulases from hydrolytic profiles over a time course using fluorescence-assisted carbohydrate electrophoresis.

    Science.gov (United States)

    Zhang, Qing; Zhang, Xiaomei; Wang, Peipei; Li, Dandan; Chen, Guanjun; Gao, Peiji; Wang, Lushan

    2015-03-01

    Fluorescence-assisted carbohydrate electrophoresis (FACE) is a sensitive and simple method for the separation of oligosaccharides. It relies on labeling the reducing ends of oligosaccharides with a fluorophore, followed by PAGE. Concentration changes of oligosaccharides following hydrolysis of a carbohydrate polymer could be quantitatively measured continuously over time using the FACE method. Based on the quantitative analysis, we suggested that FACE was a relatively high-throughput, repeatable, and suitable method for the analysis of the action modes of cellulases. On account of the time courses of their hydrolytic profiles, the apparent processivity was used to show the different action modes of cellulases. Cellulases could be easily differentiated as exoglucanases, β-glucosidases, or endoglucanases. Moreover, endoglucanases from the same glycoside hydrolases family had a variety of apparent processivity, indicating the different modes of action. Endoglucanases with the same binding capacities and hydrolytic activities had similar oligosaccharide profiles, which aided in their classification. The hydrolytic profile of Trichoderma reesei Cel12A, an endoglucanases from T. reesei, contained glucose, cellobiose, and cellotriose, which revealed that it may have a new glucosidase activity, corresponding to that of EC 3.2.1.74. A hydrolysate study of a T. reesei Cel12A-N20A mutant demonstrated that the FACE method was sufficiently sensitive to detect the influence of a single-site mutation on enzymatic activity.

  10. Finite-time sliding mode attitude control for a reentry vehicle with blended aerodynamic surfaces and a reaction control system

    Directory of Open Access Journals (Sweden)

    Geng Jie

    2014-08-01

    Full Text Available This paper proposes a finite-time robust flight controller, targeting for a reentry vehicle with blended aerodynamic surfaces and a reaction control system (RCS. Firstly, a novel finite-time attitude controller is pointed out with the introduction of a nonsingular finite-time sliding mode manifold. The attitude tracking errors are mathematically proved to converge to zero within finite time which can be estimated. In order to improve the performance, a second-order finite-time sliding mode controller is further developed to effectively alleviate chattering without any deterioration of robustness and accuracy. Moreover, an optimization control allocation algorithm, using linear programming and a pulse-width pulse-frequency (PWPF modulator, is designed to allocate torque commands for all the aerodynamic surface deflections and on–off switching-states of RCS thrusters. Simulations are provided for the reentry vehicle considering uncertain parameters and external disturbances for practical purposes, and the results demonstrate the effectiveness and robustness of the attitude control system.

  11. Finite-time sliding mode attitude control for a reentry vehicle with blended aerodynamic surfaces and a reaction control system

    Institute of Scientific and Technical Information of China (English)

    Geng Jie; Sheng Yongzhi; Liu Xiangdong

    2014-01-01

    This paper proposes a finite-time robust flight controller, targeting for a reentry vehicle with blended aerodynamic surfaces and a reaction control system (RCS). Firstly, a novel finite-time attitude controller is pointed out with the introduction of a nonsingular finite-time sliding mode manifold. The attitude tracking errors are mathematically proved to converge to zero within finite time which can be estimated. In order to improve the performance, a second-order finite-time slid-ing mode controller is further developed to effectively alleviate chattering without any deterioration of robustness and accuracy. Moreover, an optimization control allocation algorithm, using linear programming and a pulse-width pulse-frequency (PWPF) modulator, is designed to allocate torque commands for all the aerodynamic surface deflections and on-off switching-states of RCS thrusters. Simulations are provided for the reentry vehicle considering uncertain parameters and external disturbances for practical purposes, and the results demonstrate the effectiveness and robustness of the attitude control system.

  12. Sliding mode control of uncertain systems with distributed time-delay: parameter-dependent Lyapunov functional approach

    Institute of Scientific and Technical Information of China (English)

    Ligang WU; Changhong WANG; Huijun GAO; Qingshuang ZENG

    2006-01-01

    The robust stability and robust sliding mode control problems are studied for a class of linear distributed time-delay systems with polytopic-type uncertainties by applying the parameter-dependent Lyapunov functional approach combining with a new method of introducing some relaxation matrices and tuning parameters, which can be chosen properly to lead to a less conservative result. First, a sufficient condition is proposed for robust stability of the autonomic system;next, the sufficient conditions of the robust stabilization controller and the existence condition of sliding mode are developed. The results are given in terms of linear matrix inequalities (LMIs), which can be solved via efficient interior-point algorithms. A numerical example is presented to illustrate the feasibility and advantages of the proposed design scheme.

  13. Analyses of kinetic glass transition in short-range attractive colloids based on time-convolutionless mode-coupling theory

    Science.gov (United States)

    Narumi, Takayuki; Tokuyama, Michio

    2017-03-01

    For short-range attractive colloids, the phase diagram of the kinetic glass transition is studied by time-convolutionless mode-coupling theory (TMCT). Using numerical calculations, TMCT is shown to recover all the remarkable features predicted by the mode-coupling theory for attractive colloids: the glass-liquid-glass reentrant, the glass-glass transition, and the higher-order singularities. It is also demonstrated through the comparisons with the results of molecular dynamics for the binary attractive colloids that TMCT improves the critical values of the volume fraction. In addition, a schematic model of three control parameters is investigated analytically. It is thus confirmed that TMCT can describe the glass-glass transition and higher-order singularities even in such a schematic model.

  14. Phenomenological theory of a renormalized simplified model based on time-convolutionless mode-coupling theory near the glass transition

    Science.gov (United States)

    Tokuyama, Michio

    2017-01-01

    The renormalized simplified model is proposed to investigate indirectly how the static structure factor plays an important role in renormalizing a quadratic nonlinear term in the ideal mode-coupling memory function near the glass transition. The renormalized simplified recursion equation is then derived based on the time-convolutionless mode-coupling theory (TMCT) proposed recently by the present author. This phenomenological approach is successfully applied to check from a unified point of view how strong liquids are different from fragile liquids. The simulation results for those two types of liquids are analyzed consistently by the numerical solutions of the recursion equation. Then, the control parameter dependence of the renormalized nonlinear exponent in both types of liquids is fully investigated. Thus, it is shown that there exists a novel difference between the universal behavior in strong liquids and that in fragile liquids not only for their transport coefficients but also for their dynamics.

  15. Matrix Failure Modes and Effects Analysis as a Knowledge Base for a Real Time Automated Diagnosis Expert System

    Science.gov (United States)

    Herrin, Stephanie; Iverson, David; Spukovska, Lilly; Souza, Kenneth A. (Technical Monitor)

    1994-01-01

    Failure Modes and Effects Analysis contain a wealth of information that can be used to create the knowledge base required for building automated diagnostic Expert systems. A real time monitoring and diagnosis expert system based on an actual NASA project's matrix failure modes and effects analysis was developed. This Expert system Was developed at NASA Ames Research Center. This system was first used as a case study to monitor the Research Animal Holding Facility (RAHF), a Space Shuttle payload that is used to house and monitor animals in orbit so the effects of space flight and microgravity can be studied. The techniques developed for the RAHF monitoring and diagnosis Expert system are general enough to be used for monitoring and diagnosis of a variety of other systems that undergo a Matrix FMEA. This automated diagnosis system was successfully used on-line and validated on the Space Shuttle flight STS-58, mission SLS-2 in October 1993.

  16. Extending compile-time reverse mode and exploiting partial separability in ADIFOR. ADIFOR Working Note No. 7

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, C.H.; El-Khadiri, M.

    1992-10-01

    The numerical methods employed in the solution of many scientific computing problems require the computation of the gradient of a function f: R{sup n} {yields} R. ADIFOR is a source translator that, given a collection of subroutines to compute f, generates Fortran 77 code for computing the derivative of this function. Using the so-called torsion problem from the MINPACK-2 test collection as an example, this paper explores two issues in automatic differentiation: the efficient computation of derivatives for partial separable functions and the use of the compile-time reverse mode for the generation of derivatives. We show that orders of magnitudes of improvement are possible when exploiting partial separability and maximizing use of the reverse mode.

  17. Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients.

    Science.gov (United States)

    Peng, Yong-hai; Li, Jian-jun; Xie, Fang-wei; Chen, Jian-fang; Yu, Ying-hao; Ouyang, Xue-nong; Liang, Hou-jie

    2013-01-01

    Provirus integration site for Moloney murine leukemia virus (pim-1) is a proto-oncogene that is linked to the development and progression of several cancers. In this study, we evaluated pim-1 expression in tumors, tumor stroma and tumor-adjacent mucosa together as an independent prognostic factor for colon cancer patients. The study included 343 colon cancer patients. Immunohistochemical staining was used to detect pim-1. Multivariate cox regression for disease-free survival (DFS) were used to identify independent prognostic factors. Analytic hierarchy process (AHP) was used to calculate the weight of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa in order to obtain a Pim-1 total score (PTS) for recurrence and survival. Kaplan-Meier DFS curves and OS curves for patients with different pim-1 expression levels were compared using the log-rank test. In this study, four independent prognostic factors were identified for colon cancer patients: pim-1 expression in tumors, tumor stroma, tumor-adjacent mucosa, as well as tumor stage. It has been established that clinical stage is an important prognostic factor for colon cancer patients. However, PTS can identify the patients who are likely to recur not only in the whole radical excision group but also within each stage of this group. Based on the results of this study we can conclude that the PTS combined with clinical staging system may be a better predictor of colon cancer patients' prognosis than using the clinical stage system alone. ClinicalTrials.gov Number: ChiCTR-PRCH-12002842.

  18. The late time structure of high density contrast, single mode Richtmyer-Meshkov flow

    CERN Document Server

    Williams, R J R

    2016-01-01

    We study the late time flow structure of Richtmyer-Meshkov instability. Recent numerical work has suggested a self-similar collapse of the development of this instability at late times, independent of the initial surface profile. Using the form of collapse suggested, we derive an analytic expression for the mass-velocity relation in the spikes, and a global theory for the late time flow structure. We compare these results with fluid dynamical simulation.

  19. Data reconciliation using PIMs historical data: a simple and low cost approach

    Energy Technology Data Exchange (ETDEWEB)

    Fonseca, Conrad A.A.; Oliveira, Elcio Cruz de [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-12-19

    The procedure known as data reconciliation is based on measurement adjustments so that the resulting values fit within the conservation laws and the restrictions imposed by the process. The classical general data reconciliation problem deals with a weighted least-squares minimization of the measurement adjustments subject to the model constraints. The reconciliation technique allows that two or more experimental redundant measurements can be reconciled to a single value, a better representation of the quantity to be analyzed, minimizing the measurement uncertainty. A critical step in this process is the acquisition and storage of long-term data. There are commercial applications available to solve this problem, although in many cases they don't apply to the plants particularities and, in cases they do, the presented solution is usually more complex and expensive. The purpose of this work was to develop a custom tool for volume data reconciliation on oil products storage and transportation plants using the process data stored on a PIMS server. The platform chosen for this development was an Excel environment. The main novelty presented in this tool is the intrinsic simplicity gained by using an Excel environment, due to its wide range usage facilitating the customization for different plants without extra costs for the company. (author)

  20. Perspective: Is there a hysteresis during reactive High Power Impulse Magnetron Sputtering (R-HiPIMS)?

    Science.gov (United States)

    Strijckmans, K.; Moens, F.; Depla, D.

    2017-02-01

    This paper discusses a few mechanisms that can assist to answer the title question. The initial approach is to use an established model for DC magnetron sputter deposition, i.e., RSD2013. Based on this model, the impact on the hysteresis behaviour of some typical HiPIMS conditions is investigated. From this first study, it becomes clear that the probability to observe hysteresis is much lower as compared to DC magnetron sputtering. The high current pulses cannot explain the hysteresis reduction. Total pressure and material choice make the abrupt changes less pronounced, but the implantation of ionized metal atoms that return to the target seems to be the major cause. To further substantiate these results, the analytical reactive sputtering model is coupled with a published global plasma model. The effect of metal ion implantation is confirmed. Another suggested mechanism, i.e., gas rarefaction, can be ruled out to explain the hysteresis reduction. But perhaps the major conclusion is that at present, there are too little experimental data available to make fully sound conclusions.

  1. Manufacturing and characterization of PIM-W materials as plasma facing materials

    Science.gov (United States)

    Pintsuk, G.; Antusch, S.; Rieth, M.; Wirtz, M.

    2016-02-01

    Powder injection molding (PIM) was used to produce pure and particle reinforced W materials to be qualified for the use as plasma facing material. As alloying elements La2O3, Y2O3, TiC, and TaC were chosen with a particle size between 50 nm and 2.5 μm, depending on the alloying element. The fabrication of alloyed materials was done for different compositions using powder mixtures. Final sintering was performed in H2 atmosphere at 2400 °C resulting in plates of 55 × 22 × 4 mm3 with ˜98% theoretical density. The qualification of the materials was done via high heat flux testing in the electron beam facility JUDITH-1. Thereby, ELM-like 1000 thermal shock loads of 0.38 GW m-2 for 1 ms and 100 disruption like loads of 1.13 GW m-2 for 1 ms at a base temperature of 1000 °C were applied. The obtained damage characteristics, i.e. surface roughening and crack formation, were qualified versus an industrially manufactured pure reference tungsten material and linked to the material’s microstructure and mechanical properties.

  2. Continuous higher-order sliding mode control with time-varying gain for a class of uncertain nonlinear systems.

    Science.gov (United States)

    Han, Yaozhen; Liu, Xiangjie

    2016-05-01

    This paper presents a continuous higher-order sliding mode (HOSM) control scheme with time-varying gain for a class of uncertain nonlinear systems. The proposed controller is derived from the concept of geometric homogeneity and super-twisting algorithm, and includes two parts, the first part of which achieves smooth finite time stabilization of pure integrator chains. The second part conquers the twice differentiable uncertainty and realizes system robustness by employing super-twisting algorithm. Particularly, time-varying switching control gain is constructed to reduce the switching control action magnitude to the minimum possible value while keeping the property of finite time convergence. Examples concerning the perturbed triple integrator chains and excitation control for single-machine infinite bus power system are simulated respectively to demonstrate the effectiveness and applicability of the proposed approach.

  3. A time-table organizer for the planning and implementation of screenings in manual or semi-automation mode

    Science.gov (United States)

    Goktug, Asli N.; Chai, Sergio C.; Chen, Taosheng

    2013-01-01

    We have designed a software to facilitate the planning and execution of screenings performed manually or in semi-automation mode, which follow a sequential sequence of events. Many assays involve multiple steps, often including time-sensitive stages, thus complicating the proper implementation to ensure that all plates are treated equally in order to achieve reliable outcomes. The Excel Macro-Enabled Workbook presented in this study analyzes and breaks down the timings for all tasks, calculates the maximum number of plates that suit the desired parameters, and allows for optimization based on tolerance of time delay and equal treatment of plates when possible. The generated Gantt charts allow for visual inspection of the screening process, and provide timings in tabulated form to assist the user to conduct the experiments as projected by the software. The program can be downloaded from http://sourceforge.net/projects/sams-hts/. PMID:23653394

  4. One-wave optical time-reversal mirror by actively coupling arbitrary light fields into a single-mode reflector

    CERN Document Server

    Lee, KyeoReh; Park, Jung-Hoon; Park, Ji-Ho; Park, YongKeun

    2015-01-01

    Rewinding the arrow of time via phase conjugation is an intriguing phenomena made possible by the wave property of light. To exploit this phenomenon, many diverse research fields have pursed the realization of an ideal phase conjugation mirror, but the ideal phase conjugation mirror - an optical system that requires a single-input and a single-output beam, like natural conventional mirrors - has never been demonstrated. Here, we demonstrate the realization of a one-wave optical time-reversal mirror using a spatial light modulator and a single-mode reflector. Our method is simple, alignment free, and fast while allowing unlimited power throughput in the time reversed wave, which have not been simultaneously demonstrated before. Using our method, we demonstrate high throughput time-reversal full-field light delivery through highly scattering biological tissue and multimode fibers, even for quantum dot fluorescence.

  5. Time Domain Strain/Stress Reconstruction Based on Empirical Mode Decomposition: Numerical Study and Experimental Validation.

    Science.gov (United States)

    He, Jingjing; Zhou, Yibin; Guan, Xuefei; Zhang, Wei; Zhang, Weifang; Liu, Yongming

    2016-08-16

    Structural health monitoring has been studied by a number of researchers as well as various industries to keep up with the increasing demand for preventive maintenance routines. This work presents a novel method for reconstruct prompt, informed strain/stress responses at the hot spots of the structures based on strain measurements at remote locations. The structural responses measured from usage monitoring system at available locations are decomposed into modal responses using empirical mode decomposition. Transformation equations based on finite element modeling are derived to extrapolate the modal responses from the measured locations to critical locations where direct sensor measurements are not available. Then, two numerical examples (a two-span beam and a 19956-degree of freedom simplified airfoil) are used to demonstrate the overall reconstruction method. Finally, the present work investigates the effectiveness and accuracy of the method through a set of experiments conducted on an aluminium alloy cantilever beam commonly used in air vehicle and spacecraft. The experiments collect the vibration strain signals of the beam via optical fiber sensors. Reconstruction results are compared with theoretical solutions and a detailed error analysis is also provided.

  6. Time Domain Strain/Stress Reconstruction Based on Empirical Mode Decomposition: Numerical Study and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Jingjing He

    2016-08-01

    Full Text Available Structural health monitoring has been studied by a number of researchers as well as various industries to keep up with the increasing demand for preventive maintenance routines. This work presents a novel method for reconstruct prompt, informed strain/stress responses at the hot spots of the structures based on strain measurements at remote locations. The structural responses measured from usage monitoring system at available locations are decomposed into modal responses using empirical mode decomposition. Transformation equations based on finite element modeling are derived to extrapolate the modal responses from the measured locations to critical locations where direct sensor measurements are not available. Then, two numerical examples (a two-span beam and a 19956-degree of freedom simplified airfoil are used to demonstrate the overall reconstruction method. Finally, the present work investigates the effectiveness and accuracy of the method through a set of experiments conducted on an aluminium alloy cantilever beam commonly used in air vehicle and spacecraft. The experiments collect the vibration strain signals of the beam via optical fiber sensors. Reconstruction results are compared with theoretical solutions and a detailed error analysis is also provided.

  7. Sliding Mode Real-Time Control of Photovoltaic Systems Using Neural Estimators

    Directory of Open Access Journals (Sweden)

    J. A. Ramos-Hernanz

    2016-01-01

    Full Text Available The maximum power point tracking (MPPT problem has attracted the attention of many researchers, because it is convenient to obtain the maximum power of a photovoltaic module regardless of the weather conditions and the load. In this paper, a novel control for a boost DC/DC converter has been introduced. It is based on a sliding mode controller (SMC that takes a current signal as reference instead of a voltage, which is generated by a neuronal reference current generator. That reference current indicates the current (IMPP at the maximum power point (MPP for given weather conditions. In order to test the designed control system, a photovoltaic module model based on a second artificial neuronal network (ANN has been obtained from experimental data gathered during 18 months in the Faculty of Engineering Vitoria-Gasteiz (Spain. We have analyzed the performance of such model and we found that it is very accurate (MSE = 0.062 A and R = 0.991 with test dataset. We also have tested the performance of the overall SMC design with both simulated and real tests, concluding that it guarantees that the power in the output of the converter is very close to the power of the photovoltaic module output.

  8. Comparação entre dois escores de prognóstico (PRISM e PIM em unidade de terapia intensiva pediátrica Comparison of two prognostic scores (PRISM and PIM at a pediatric intensive care unit

    Directory of Open Access Journals (Sweden)

    Vanessa Feller Martha

    2005-06-01

    Full Text Available OBJETIVO: Comparar o desempenho do PRISM (Pediatric Risk of Mortality e o PIM (Pediatric Index of Mortality em uma unidade de terapia intensiva pediátrica geral investigando a relação existente entre a mortalidade e a sobrevivência observadas com a mortalidade e sobrevivência estimadas pelos dois escores. MÉTODOS: Estudo de coorte contemporâneo realizado entre 1° de junho de 1999 a 31 de maio de 2000 na unidade de terapia intensiva pediátrica do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul. Os critérios de inclusão no estudo e o cálculo do PRISM e do PIM foram feitos conforme preconizado e utilizando as fórmulas de seus artigos originais. Para estatística, utilizou-se o teste z de Flora, teste de ajuste de Hosmer-Lemeshow, área sob a curva típica de um recebedor operador de características (curva ROC e teste de correlação de Spearman. O estudo foi aprovado pelo Comitê da instituição. RESULTADOS: Internaram na unidade de terapia intensiva pediátrica 498 pacientes, sendo 77 excluídos. Dos 421 pacientes estudados, 33 (7,83% foram a óbito. A mortalidade estimada pelo PRISM foi de 30,84 (7,22%, com standardized mortality rate 1,07 (0,74-1,50, z = -0,45. Pelo PIM, foi de 26,13 (6,21%, com standardized mortality rate 1,26 (0,87-1,77, z = -1,14. O teste de ajuste de Hosmer-Lemeshow obteve um qui-quadrado 9,23 (p = 0,100 para o PRISM e 27,986 (p OBJECTIVE: To compare the performance of the PRISM (Pediatric Risk of Mortality and the PIM (Pediatric Index of Mortality scores at a general pediatric intensive care unit, investigating the relation between observed mortality and survival and predicted mortality and survival. METHODS: A contemporary cohort study undertaken between 1 June 1999 and 31 May 2000 at the Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas pediatric intensive care unit. The inclusion criteria and the PRISM and PIM calculations were performed as set out

  9. Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes.

    Science.gov (United States)

    Kurokawa, Hiromi; Aoki, Yumiko; Nakamura, Shuhei; Ebe, Youko; Kobayashi, Daisuke; Tanaka, Minoru

    2006-04-01

    Previous studies have shown that medaka primordial germ cells (PGC) are first distinguishable by olvas expression during late gastrulation, and that they migrate to the gonadal region through the lateral plate mesoderm. Here, we demonstrate that medaka nanos expression marks the germ line at early gastrulation stage. By marking the germ line with green fluorescent protein (GFP) fused to the nanos 3' untranslated region, we were able to visualize the behavior of PGC using time-lapse imaging. We show that there are three distinct modes of PGC migration that function at different stages of development. At early gastrulation stage, PGC actively migrate towards the marginal zone, a process that requires the function of a chemokine receptor, CXCR4. However, at late gastrulation stage, PGC change the mode and direction of their movement, as they are carried towards the midline along with somatic cells undergoing convergent movements. After aligning bilaterally, PGC actively migrate to the posterior end of the lateral plate mesoderm. This posterior movement depends on the activity of both HMGCoAR and a ligand of CXCR4, SDF-1a. These results demonstrate that PGC undergo different modes of migration to reach the prospective gonadal region of the embryo.

  10. Comparison of the veracity of real-time perfusion, harmonic angio, and ultraharmonic myocardial contrast imaging modes in evaluation of acute myocardial infarction area

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background Innovative advancements in ultrasound instrumentation present a number of imaging modalities for myocardial contrast echocardiography (MCE) in ischemic syndromes. How well they compare to each other in diagnostic accuracy in the detection of acute myocardial infarction is unclear. The purpose of this study was to assess the relative accuracy of 3 different imaging modes of MCE, low mechanical index (MI) real-time perfusion imaging (RTPI), triggered harmonic angio mode (HA), and ultraharmonic imaging mode (UH) in the detection of acute experimental myocardial infarction within the time frame suitable for potential reperfusion. Methods MCE was performed in 10 open-chest dogs using RTPI, triggered HA and triggered UH modes at baseline and one hour after occlusion of left anterior descending coronary artery. Presence or absence of perfusion defects, and the perfusion defect size when present, were analyzed and compared with the infarct size delineated by triphenyltetrazolium chloride(TTC)staining. Results The infarct area was (15.8±2.4)% by TTC staining; Perfusion defect area by MCE was similar to anatomic infarct area in all the three MCE approaches: (16.1±2.7)% by RTPI mode, (15.5±2.9)% by HA mode, and (15.5±3.0)% by UH mode. The sensitivity, specificity and overall diagnostic accuracy in the detection of myocardial infarction were 100%, 88%, and 94% for RTPI mode, 88%, 100%, and 94 % for HA mode, and 100%, 75%, and 88% for UH mode. Conclusion All modes of MCE, RTPI, triggered HA mode and triggered UH mode have excellent diagnostic accuracy in the immediate hour of acute coronary occlusion within the optimal time frame suitable for reperfusion therapy.

  11. Non-physiological increase of AV conduction time in sinus disease patients programmed in AAIR-based pacing mode.

    Science.gov (United States)

    Mabo, Philippe; Cebron, Jean-Pierre; Solnon, Aude; Tassin, Aude; Graindorge, Laurence; Gras, Daniel

    2012-11-01

    The EVOCAV(DS) trial aimed to quantify the paradoxal atrioventricular (AV) conduction time lengthening in sinus node (SD) patients (pts) paced in AAIR-based pacing mode. SD pts, implanted with dual-chamber pacemaker programmed in AAIR-based pacing mode, were randomized in two arms for a 1-month period: the low atrial pacing (LAP; basic rate at 60 bpm, dual sensor with minimal slope) and the high atrial pacing (HAP; basic rate at 70 bpm, dual sensor with optimized slope, overdrive pacing) arm. At 1 month, crossover was performed for an additional 1-month period. AV conduction time, AV block occurrence and AV conduction time adaptation during exercise were ascertained from device memories at each follow-up. Seventy-nine pts participated to the analysis (75 ± 8 years; 32 male; PR = 184 ± 38 ms; bundle branch block n = 12; AF history n = 36; antiarrhythmic treatment n = 53; beta-blockers n = 27; class III/Ic n = 18; both n = 8). The mean AV conduction time was significantly greater during the HAP (275 ± 51 ms) vs. LAP (263 ± 49 ms) period (p AV blocks occurred in 49 % of pts in the HAP vs. 19 % in the LAP period (p AV conduction time during exercise. AAIR-based pacing in SD pts may induce a significant lengthening of pts' AV conduction time, including frequent abnormal adaptation of AV conduction time during exercise.

  12. Movement and Time in the Nexus between Technological Modes with Jean Tinguely’s Kineticism

    Directory of Open Access Journals (Sweden)

    Christina Chau

    2014-12-01

    Full Text Available This paper addresses auto-destructive artworks by Jean Tinguely, Homage to New York (1960 and Study for an End of the World No. 2 (1962, to explore a changing consciousness of time in a period of technological transition from modern industrial machines towards the domestication of televisual devices. One effect of these is works is a contribution to a turbulent consciousness of time by orchestrating new perceptions of temporality with mechanical and tele-communicational media. Tinguely’s kineticism is useful for articulating how different technologies can be used to rationalize time in different ways and highlight an incompatibility between the expression of time as an unfolding duration with mechanical media, and the temporal demands of televisual broadcast media.

  13. A variational principle for the description of time-dependent modes associated with transient instabilities

    CERN Document Server

    Babaee, Hessam

    2015-01-01

    We introduce a variational formulation for the determination of a finite-dimensional, time-dependent, orthonormal basis that captures directions of the phase space associated with transient instabilities. While these instabilities have finite lifetime they can play a crucial role by either altering the system dynamics through the activation of other instabilities, or by creating sudden nonlinear energy transfers that lead to extreme responses. However, their essentially transient character makes their description a particularly challenging task. We develop a variational framework that focuses on the optimal approximation of the system dynamics over finite-time intervals. This variational formulation results in differential equations that evolve a time-dependent basis so that it optimally approximates the most unstable directions over finite times. We demonstrate the capability of the method for two families of problems: i) linear systems including the advection-diffusion operator in a strongly non-normal regi...

  14. Model-Based Real Time Assessment of Capability Left for Spacecraft Under Failure Mode Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed project is aimed at developing a model based diagnostics system for spacecraft that will allow real time assessment of its state, while it is impacted...

  15. Factors influencing modes of transport and travel time for obstetric care: a mixed methods study in Zambia and Uganda.

    Science.gov (United States)

    Sacks, Emma; Vail, Daniel; Austin-Evelyn, Katherine; Greeson, Dana; Atuyambe, Lynn M; Macwan'gi, Mubiana; Kruk, Margaret E; Grépin, Karen A

    2016-04-01

    Transportation is an important barrier to accessing obstetric care for many pregnant and postpartum women in low-resource settings, particularly in rural areas. However, little is known about how pregnant women travel to health facilities in these settings. We conducted 1633 exit surveys with women who had a recent facility delivery and 48 focus group discussions with women who had either a home or a facility birth in the past year in eight districts in Uganda and Zambia. Quantitative data were analysed using univariate statistics, and qualitative data were analysed using thematic content analysis techniques. On average, women spent 62-68 min travelling to a clinic for delivery. Very different patterns in modes of transport were observed in the two countries: 91% of Ugandan women employed motorized forms of transportation, while only 57% of women in Zambia did. Motorcycle taxis were the most commonly used in Uganda, while cars, trucks and taxis were the most commonly used mode of transportation in Zambia. Lower-income women were less likely to use motorized modes of transportation: in Zambia, women in the poorest quintile took 94 min to travel to a health facility, compared with 34 for the wealthiest quintile; this difference between quintiles was ∼50 min in Uganda. Focus group discussions confirmed that transport is a major challenge due to a number of factors we categorized as the 'three A's:' affordability, accessibility and adequacy of transport options. Women reported that all of these factors had influenced their decision not to deliver in a health facility. The two countries had markedly different patterns of transportation for obstetric care, and modes of transport and travel times varied dramatically by wealth quintile, which policymakers need to take into account when designing obstetric transport interventions.

  16. A Real-Time Sliding Mode Control for a Wind Energy System Based on a Doubly Fed Induction Generator

    Directory of Open Access Journals (Sweden)

    Oscar Barambones

    2014-10-01

    Full Text Available In this paper, a real time sliding mode control scheme for a variable speed wind turbine that incorporates a doubly feed induction generator is described. In this design, the so-called vector control theory is applied, in order to simplify the system electrical equations. The proposed control scheme involves a low computational cost and therefore can be implemented in real-time applications using a low cost Digital Signal Processor (DSP. The stability analysis of the proposed sliding mode controller under disturbances and parameter uncertainties is provided using the Lyapunov stability theory. A new experimental platform has been designed and constructed in order to analyze the real-time performance of the proposed controller in a real system. Finally, the experimental validation carried out in the experimental platform shows; on the one hand that the proposed controller provides high-performance dynamic characteristics, and on the other hand that this scheme is robust with respect to the uncertainties that usually appear in the real systems.

  17. Active quench and reset integrated circuit with novel hold-off time control logic for Geiger-mode avalanche photodiodes.

    Science.gov (United States)

    Deng, Shijie; Morrison, Alan P

    2012-09-15

    This Letter presents an active quench-and-reset circuit for Geiger-mode avalanche photodiodes (GM-APDs). The integrated circuit was fabricated using a conventional 0.35 μm complementary metal oxide semiconductor process. Experimental results show that the circuit is capable of linearly setting the hold-off time from several nanoseconds to microseconds with a resolution of 6.5 ns. This allows the selection of the optimal afterpulse-free hold-off time for the GM-APD via external digital inputs or additional signal processing circuitry. Moreover, this circuit resets the APD automatically following the end of the hold-off period, thus simplifying the control for the end user. Results also show that a minimum dead time of 28.4 ns is achieved, demonstrating a saturated photon-counting rate of 35.2 Mcounts/s.

  18. Terahertz imaging of composite materials in reflection and transmission mode with a time-domain spectroscopy system

    Science.gov (United States)

    Sørgârd, Trygve R.; van Rheenen, Arthur D.; Haakestad, Magnus W.

    2016-02-01

    A fiber-coupled Terahertz time domain spectroscopy (THz-TDS) system based on photoconductive antennas, pumped by a 100-fs fiber laser, has been used to characterize materials in transmission and reflection mode. THz images are acquired by mounting the samples under investigation on an x-y stage, which is stepped through the beam while the transmitted or reflected THz waveform is captured. The samples include a carbon fiber epoxy composite and a sandwich-structured composite panel with an aramid fiber honeycomb core in between two skin layers of fiberglass reinforced plastic. The former has an artificially induced void, and from a comparison of recorded reflected time-domain signals, with and without the void, a simple model for the structure of the composite is proposed that describes the time-domain signals reasonably well.

  19. Relationship between Timing Jitter and Prism Separation in Mode-locked Solid State Lasers

    Institute of Scientific and Technical Information of China (English)

    LU Hong

    2001-01-01

    The function expression of the group delay dispersion (GDD) depending on the prism separation and the normal displacement is derived, and that the GDD is proportional to the prism separation and near to a linear function of the normal displacement in the case of small normal displacement are found. Then we discuss the timing jitter caused by the amplified spontaneous emission (ASE) which depends on the prism separation and the normal displacement. We find that the timing jitter is near to a linear function of the prism separation and can be regrded as a linear function of the normal displacement in the case of small normal displacement. Based on the theoretic work, we suggest an experimental setup to measure the relationship between the timing jitter and the prism separation or the normal displacement.

  20. Test of high time resolution MRPC with different readout modes for the BESIII upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Yang, S. [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Sun, Y.J., E-mail: sunday@ustc.edu.cn [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Li, C., E-mail: licheng@ustc.edu.cn [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Heng, Y.K.; Qian, S. [Institute of High Energy Physics, Chinese Academy of Sciences(IHEP), Beijing 100049 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Chen, H.F.; Chen, T.X. [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Dai, H.L. [Institute of High Energy Physics, Chinese Academy of Sciences(IHEP), Beijing 100049 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Fan, H.H.; Liu, S.B. [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Liu, S.D.; Jiang, X.S. [Institute of High Energy Physics, Chinese Academy of Sciences(IHEP), Beijing 100049 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China); Shao, M.; Tang, Z.B.; Zhang, H.; Zhao, Z.G. [Department of Modern Physics, University of Science and Technology of China(USTC), Hefei 230026 (China); State Key Laboratory of Particle Detection and Electronics(USTC-IHEP) (China)

    2014-11-01

    In order to further enhance the particle identification capability of the Beijing Spectrometer (BESIII), it is proposed to upgrade the current end-cap time-of-flight (eTOF) detector with multi-gap resistive plate chamber (MRPC). The prototypes, together with the front end electronics (FEE) and time digitizer (TDIG) module have been tested at the E3 line of Beijing Electron Positron Collider (BEPCII) to study the difference between the single and double-end readout MRPC designs. The time resolutions (sigma) of the single-end readout MRPC are 47/53 ps obtained by 600 MeV/c proton/pion beam, while that of the double-end readout MRPC is 40 ps (proton beam). The efficiencies of three MRPC modules tested by both proton and pion beam are better than 98%. For the double-end readout MRPC, no incident position dependence is observed.

  1. Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode

    DEFF Research Database (Denmark)

    Biering-Sørensen, Tor; Mogelvang, Rasmus; Schnohr, Peter

    2016-01-01

    BACKGROUND: We hypothesized that the cardiac time intervals reveal reduced myocardial function in persons with hypertension and are strong predictors of future ischemic cardiovascular diseases in the general population. METHODS AND RESULTS: In a large community-based population study, cardiac......). Additionally, they displayed a significant dose-response relationship, between increasing severity of elevated blood pressure and increasing left ventricular mass index (P... chart, and the European Society of Hypertension/European Society of Cardiology risk chart. CONCLUSION: The cardiac time intervals identify impaired cardiac function in individuals with hypertension, not only independent of conventional risk factors but also in participants with a normal conventional...

  2. Multiscale Detrended Cross-Correlation Analysis of Traffic Time Series Based on Empirical Mode Decomposition

    Science.gov (United States)

    Yin, Yi; Shang, Pengjian

    2015-04-01

    In this paper, we propose multiscale detrended cross-correlation analysis (MSDCCA) to detect the long-range power-law cross-correlation of considered signals in the presence of nonstationarity. For improving the performance and getting better robustness, we further introduce the empirical mode decomposition (EMD) to eliminate the noise effects and propose MSDCCA method combined with EMD, which is called MS-EDXA method, then systematically investigate the multiscale cross-correlation structure of the real traffic signals. We apply the MSDCCA and MS-EDXA methods to study the cross-correlations in three situations: velocity and volume on one lane, velocities on the present and the next moment and velocities on the adjacent lanes, and further compare their spectrums respectively. When the difference between the spectrums of MSDCCA and MS-EDXA becomes unobvious, there is a crossover which denotes the turning point of difference. The crossover results from the competition between the noise effects in the original signals and the intrinsic fluctuation of traffic signals and divides the plot of spectrums into two regions. In all the three case, MS-EDXA method makes the average of local scaling exponents increased and the standard deviation decreased and provides a relative stable persistent scaling cross-correlated behavior which gets the analysis more precise and more robust and improves the performance after noises being removed. Applying MS-EDXA method avoids the inaccurate characteristics of multiscale cross-correlation structure at the short scale including the spectrum minimum, the range for the spectrum fluctuation and general trend, which are caused by the noise in the original signals. We get the conclusions that the traffic velocity and volume are long-range cross-correlated, which is accordant to their actual evolution, while velocities on the present and the next moment and velocities on adjacent lanes reflect the strong cross-correlations both in temporal and

  3. Modes and times of caldera resurgence: The Ischia Caldera, Italy, from high-precision archaeomagnetic dating

    Science.gov (United States)

    Vezzoli, Luigina; Principe, Claudia; Malfatti, Jonas; Arrighi, Simone; Tanguy, Jean-Claude; Le Goff, Maxime

    2009-10-01

    Ischia is a well exposed and densely populated late Quaternary caldera in the Campanian magmatic province of Italy. Ischia Caldera experienced an average uplift rate of 3.3 cm/year in the last ca. 30 ka and is still actively resurging. During the last 10 ka, coeval with the resurgence, a volcanic field of alkali-trachytic to trachyandesitic lava domes, lava flows, tuff and scoria rings, and pumice cones developed, mainly on the eastern sector of the caldera, along both resurgence-related faults and regional NNW- and NE-striking faults. In order to improve both our understanding of the recent volcanic history and the evaluation of future risks on Ischia Island, a high-precision archaeomagnetic dating method was applied to the products of 12 volcanic centres with probable age Ischia volcanism occurred in five periods separated by phases of quiescence and coeval with earthquake and landslide events. This fact suggests a pulsating mode of uplifting and deformations of the Ischia resurgence. During the two oldest periods of activity (7200-6800 BC and 4100-2300 BC), resurgence probably produced a dome-shaped structure. Location and geometry of vents suggest the occurrence of magma uprise along the fractures produced by bending of the overburden crustal block. Most of magma was emplaced as intrusions at the interior of the resurgent block, whereas volcanism was represented by very viscous, differentiated, and crystallized lavas that emplaced as domes and high aspect-ratio flows. The resurgent dome caused recurrent lateral collapses that removed about 2.5 km 3 of rocks. During the three youngest periods of activity (1800-1000 BC; 650 BC -355 AD; and 1302 AD), resurgence affected a fault-bounded, asymmetric block. This resulted from both (a) hydrostatic rebound of the crustal block after removal of material involved into huge slope instability triggering an increase in uplift rate, and (b) new influxes of less evolved magma batches into the shallow reservoir that, in turn

  4. Real time B-mode mapping of the greater saphenous vein

    DEFF Research Database (Denmark)

    Bagi, P; Schroeder, T; Sillesen, H;

    1989-01-01

    Real time ultrasound mapping of the greater saphenous vein (GSV) was performed in 30 consecutive patients admitted for in situ femoro-crural revascularisation. The overall accuracy in predicting the adequacy of the GSV for in situ bypass was 90%. The predictive value of finding the vein usable...

  5. Use of risk assessment analysis by failure mode, effects, and criticality to reduce door-to-balloon time.

    Science.gov (United States)

    Khare, Rahul K; Nannicelli, Anna P; Powell, Emilie S; Seivert, Nicholas P; Adams, James G; Holl, Jane L

    2013-10-01

    The Centers for Medicare & Medicaid Services currently endorses a door-to-balloon time of 90 minutes or less for patients presenting to the emergency department (ED) with ST-segment elevation myocardial infarction. Recent evidence shows that a door-to-balloon time of 60 minutes significantly decreases inhospital mortality. We seek to use a proactive risk assessment method of failure mode, effects, and criticality analysis (FMECA) to evaluate door-to-balloon time process, to investigate how each component failure may affect the performance of a system, and to evaluate the frequency and the potential severity of harm of each failure. We conducted a 2-part study: FMECA of the door-to-balloon time system and process of care, and evaluation of a single institution's door-to-balloon time operational data using a retrospective observational cohort design. A multidisciplinary group of FMECA participants described the door-to-balloon time process to then create a comprehensive map and table listing all process steps and identified process failures, including their frequency, consequence, and causes. Door-to-balloon time operational data were assessed by "on" versus "off" hours. Fifty-one failure points were identified across 4 door-to-balloon time phases. Of the 12 high-risk failures, 58% occurred between ECG and catheterization laboratory activation. Total door-to-balloon time during on hours had a median time of 55 minutes (95% confidence interval 46 to 60 minutes) compared with 77 minutes (95% confidence interval 68 to 83 minutes) during off hours. The FMECA revealed clear areas of potential delay and vulnerability that can be addressed to decrease door-to-balloon time from 90 to 60 minutes. FMECAs can provide a robust assessment of potential risks and can serve as the platform for significant process improvement and system redesign for door-to-balloon time. Copyright © 2013 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

  6. A deteriorating two-system with two repair modes and sojourn times phase-type distributed

    Energy Technology Data Exchange (ETDEWEB)

    Montoro-Cazorla, Delia [Departamento de Estadistica e I.O., Escuela Politecnica de Linares, Universidad de Jaen, 23700 Linares, Jaen (Spain); Perez-Ocon, Rafael [Departamento de Estadistica e I.O., Facultad de Ciencias, Universidad de Granada, Granada 18071 (Spain)]. E-mail: rperezo@ugr.es

    2006-01-01

    We study a two-unit cold standby system in steady-state. The online unit goes through a finite number of stages of successive degradation preceding the failure. The units are reparable, there is a repairman and two types of maintenance are considered, preventive and corrective. The preventive repair aims to improve the degradation of a unit being operative. The corrective repair is necessary when the unit fails. We will assume that the preventive repair will be interrupted in favour of a corrective repair in order to increase the availability of the system. The random operational and repair times follow phase-type distributions. For this system, the stationary probability vector, the replacement times, and the involved costs are calculated. An optimisation problem is illustrated by a numerical example. In this, the optimal degradation stage for the preventive repair of the online unit is determined by taking into account the system availability and the incurred costs.

  7. Time-of-Flight Three Dimensional Neutron Diffraction in Transmission Mode for Mapping Crystal Grain Structures

    DEFF Research Database (Denmark)

    Cereser, Alberto; Strobl, Markus; Hall, Stephen A.

    2017-01-01

    constituting the material. This article presents a new non-destructive 3D technique to study centimeter-sized bulk samples with a spatial resolution of hundred micrometers: time-of-flight three-dimensional neutron diffraction (ToF 3DND). Compared to existing analogous X-ray diffraction techniques, ToF 3DND...... enables studies of samples that can be both larger in size and made of heavier elements. Moreover, ToF 3DND facilitates the use of complicated sample environments. The basic ToF 3DND setup, utilizing an imaging detector with high spatial and temporal resolution, can easily be implemented at a time....... The reconstruction algorithms have been validated by reconstructing two stacked Co-Ni-Ga single crystals, and by comparison with a grain map obtained by post-mortem electron backscatter diffraction (EBSD)....

  8. Explicit finite-difference time domain for nonlinear analysis of waveguide modes

    Science.gov (United States)

    Barakat, N. M.; Shabat, M. M.; El-Azab, S.; Jaeger, Dieter

    2003-07-01

    The Finite Difference Time Domain Technique is at present the most widely used tool employed in the study of light propagation in various photonic waveguide structure. In this paper we derived an explicit finite-difference time-domain (FDTD) method for solving the wave equation in a four optical waveguiding rectangular structure. We derive the stability condition to achieve the stability in nonlinear media region, we also check that the wave equation used is consistence and convergent with the approximate finite difference equation. Our method is tested against some previous problems and we find a high degree of accuracy, moreover it is easy for programming. Numerical results are illustrated for a rectangular waveguide with four layers, where one of these layers is a nonlinear medium.

  9. Time-of-Flight Three Dimensional Neutron Diffraction in Transmission Mode for Mapping Crystal Grain Structures

    DEFF Research Database (Denmark)

    Cereser, Alberto; Strobl, Markus; Hall, Stephen A.

    2017-01-01

    constituting the material. This article presents a new non-destructive 3D technique to study centimeter-sized bulk samples with a spatial resolution of hundred micrometers: time-of-flight three-dimensional neutron diffraction (ToF 3DND). Compared to existing analogous X-ray diffraction techniques, ToF 3DND......-of-flight neutron beamline. The technique was developed and tested with data collected at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Complex (J-PARC) for an iron sample. We successfully reconstructed the shape of 108 grains and developed an indexing procedure...... enables studies of samples that can be both larger in size and made of heavier elements. Moreover, ToF 3DND facilitates the use of complicated sample environments. The basic ToF 3DND setup, utilizing an imaging detector with high spatial and temporal resolution, can easily be implemented at a time...

  10. An 11-bit ENOB, accuracy-programmable, and non-calibrating time-mode SAR ADC

    Institute of Scientific and Technical Information of China (English)

    Fan Hua; Han Xue; Wei Qi; Yang Huazhong

    2013-01-01

    A 10 or 12 bit programmable successive approximation register (SAR) ADC incorporating improved time-domain comparator for bridge stress monitoring systems is presented.Techniques for improving the accuracy of time-domain comparator are presented.The application of these approaches is illustrated using results from an experimental 10 or 12 bit programmable SAR ADC.Prototyped in a 0.18-μm,6M1P CMOS process,the ADC,at 12 bit,100 kS/s,achieves a Nyquist signal-to-noise-plus-distortion ratio (SNDR) of 68 dB (11 ENOB),a spurious free dynamic range (SFDR) of 77.48 dB,while dissipating 558 μW from a 1.8-V supply.Its differential nonlinearity (DNL) and integral nonlinearity (INL) are 0.2/-0.74 LSB and + 1.27/-0.97 LSB,respectively.

  11. Adaptive variable-structure finite-time mode control for spacecraft proximity operations with actuator saturation

    Science.gov (United States)

    Lee, Daero; Vukovich, George; Gui, Haichao

    2017-05-01

    This paper presents an adaptive variable-structure finite-time control for spacecraft proximity maneuvers under parameter uncertainties, external disturbances and actuator saturation. The coupled six degrees-of-freedom dynamics are modeled for spacecraft relative motion, where the exponential coordinates on the Lie group SE(3) are employed to describe relative configuration. No prior knowledge of inertia matrix and mass of the spacecraft is required for the proposed control law, which implies that the proposed control scheme can be applied in spacecraft systems with large parametric uncertainties in inertia matrix and mass. Finite-time convergence of the feedback system with the proposed control law is established. Numerical simulation results are presented to illustrate the effectiveness of the proposed control law for spacecraft proximity operations with actuator saturation.

  12. Relaxation times and modes of disturbed aggregate distribution in micellar solutions with fusion and fission of micelles

    Energy Technology Data Exchange (ETDEWEB)

    Zakharov, Anatoly I.; Adzhemyan, Loran Ts.; Shchekin, Alexander K., E-mail: akshch@list.ru [Department of Statistical Physics, Faculty of Physics, St. Petersburg State University, Ulyanovskaya 1, Petrodvoretz, St. Petersburg 198504 (Russian Federation)

    2015-09-28

    We have performed direct numerical calculations of the kinetics of relaxation in the system of surfactant spherical micelles under joint action of the molecular mechanism with capture and emission of individual surfactant molecules by molecular aggregates and the mechanism of fusion and fission of the aggregates. As a basis, we have taken the difference equations of aggregation and fragmentation in the form of the generalized kinetic Smoluchowski equations for aggregate concentrations. The calculations have been made with using the droplet model of molecular surfactant aggregates and two modified Smoluchowski models for the coefficients of aggregate-monomer and aggregate-aggregate fusions which take into account the effects of the aggregate size and presence of hydrophobic spots on the aggregate surface. A full set of relaxation times and corresponding relaxation modes for nonequilibrium aggregate distribution in the aggregation number has been found. The dependencies of these relaxation times and modes on the total concentration of surfactant in the solution and the special parameter controlling the probability of fusion in collisions of micelles with other micelles have been studied.

  13. Testing Rate Dependent corrections on timing mode EPIC-pn spectra of the accreting Neutron Star GX 13+1

    CERN Document Server

    Pintore, F; di Salvo, T; Guainazzi, M; D'Aì, A; Riggio, A; Burderi, L; Iaria, R; Robba, N R

    2014-01-01

    When the EPIC-pn instrument on board XMM-Newton is operated in Timing mode, high count rates (>100 cts/s) of bright sources may affect the calibration of the energy scale, resulting in a modification of the real spectral shape. The corrections related to this effect are then strongly important in the study of the spectral properties. Tests of these calibrations are more suitable in sources which spectra are characterised by a large number of discrete features. Therefore, in this work, we carried out a spectral analysis of the accreting Neutron Star GX 13+1, which is a dipping source with several narrow absorption lines and a broad emission line in its spectrum. We tested two different correction approaches on an XMM-Newton EPIC-pn observation taken in Timing mode: the standard Rate Dependent CTI (RDCTI or epfast) and the new, Rate Dependent Pulse Height Amplitude (RDPHA) corrections. We found that, in general, the two corrections marginally affect the properties of the overall broadband continuum, while hints...

  14. Emergence of time-horizon invariant correlation structure in financial returns by subtraction of the market mode

    Science.gov (United States)

    Borghesi, Christian; Marsili, Matteo; Miccichè, Salvatore

    2007-08-01

    We investigate the emergence of a structure in the correlation matrix of assets’ returns as the time horizon over which returns are computed increases from the minutes to the daily scale. We analyze data from different stock markets (New York, Paris, London, Milano) and with different methods. In addition to the usual correlations, we also analyze those obtained by subtracting the dynamics of the “center of mass” (i.e., the market mode). We find that when the center of mass is not removed the structure emerges, as the time horizon increases, from splitting a single large cluster into smaller ones. By contrast, when the market mode is removed the structure of correlations observed at the daily scale is already well defined at very high frequency ( 5min in the New York Stock Exchange). Moreover, this structure accounts for 80% of the classification of stocks in economic sectors. Similar results, though less sharp, are found for the other markets. We also find that the structure of correlations in the overnight returns is markedly different from that of intraday activity.

  15. Emergence of time-horizon invariant correlation structure in financial returns by subtraction of the market mode.

    Science.gov (United States)

    Borghesi, Christian; Marsili, Matteo; Miccichè, Salvatore

    2007-08-01

    We investigate the emergence of a structure in the correlation matrix of assets' returns as the time horizon over which returns are computed increases from the minutes to the daily scale. We analyze data from different stock markets (New York, Paris, London, Milano) and with different methods. In addition to the usual correlations, we also analyze those obtained by subtracting the dynamics of the "center of mass" (i.e., the market mode). We find that when the center of mass is not removed the structure emerges, as the time horizon increases, from splitting a single large cluster into smaller ones. By contrast, when the market mode is removed the structure of correlations observed at the daily scale is already well defined at very high frequency (5 min in the New York Stock Exchange). Moreover, this structure accounts for 80% of the classification of stocks in economic sectors. Similar results, though less sharp, are found for the other markets. We also find that the structure of correlations in the overnight returns is markedly different from that of intraday activity.

  16. Finite-time control for asteroid hovering and landing via terminal sliding-mode guidance

    Science.gov (United States)

    Yang, Hongwei; Bai, Xiaoli; Baoyin, Hexi

    2017-03-01

    This paper proposes a new nonlinear guidance algorithm applicable for asteroid both hovering and landing. With the new guidance, a spacecraft achieves its target position and velocity in finite-time without the requirement of reference trajectories. The global stability is proven for the controlled system. A parametric analysis is conducted to illustrate the parameters' effects on the guidance algorithm. Simulations of straight landing, hovering to hovering and landing with a prior hovering phase of the highly irregular asteroid 2063 Bacchus are presented and the effectiveness of the proposed method is demonstrated.

  17. Nanoscale optical thermometry using a time-correlated single-photon counting in an illumination-collection mode

    Science.gov (United States)

    Seto, Daichi; Nikka, Ren; Nishio, Shogo; Taguchi, Yoshihiro; Saiki, Toshiharu; Nagasaka, Yuji

    2017-01-01

    A nanoscale thermometry method called fluorescence near-field optics thermal nanoscopy (Fluor-NOTN) has been developed using near-field fluorescence imaging. This method can detect local temperature distributions with a nanoscale spatial resolution by measuring the fluorescence lifetimes of Cd/Se quantum dots (QDs) as a temperature probe. To increase the sensitivity of Fluor-NOTN, time-correlated single-photon counting (TCSPC) was introduced with a triple-tapered fusion-spliced near-field (TFN) optical fiber probe. This highly sensitive technique for measuring the fluorescence lifetime of QDs enabled the detection of low-level light signals with a picosecond time resolution at high-precision in an illumination-collection mode for Fluor-NOTN. The feasibility of this proposed method was experimentally verified by measuring the temperature dependence of the fluorescence lifetimes of the QDs by Fluor-NOTN using TCSPC with a TFN optical fiber probe with an aperture of 70 nm.

  18. Quasinormal modes and thermodynamics of linearly charged BTZ black holes in massive gravity in (anti) de Sitter space-time

    Energy Technology Data Exchange (ETDEWEB)

    Prasia, P.; Kuriakose, V.C. [Cochin University of Science and Technology, Department of Physics, Kochi (India)

    2017-01-15

    In this work we study the Quasi-Normal Modes (QNMs) under massless scalar perturbations and the thermodynamics of linearly charged BTZ black holes in massive gravity in the (Anti)de Sitter ((A)dS) space-time. It is found that the behavior of QNMs changes with the massive parameter of the graviton and also with the charge of the black hole. The thermodynamics of such black holes in the (A)dS space-time is also analyzed in detail. The behavior of specific heat with temperature for such black holes gives an indication of a phase transition that depends on the massive parameter of the graviton and also on the charge of the black hole. (orig.)

  19. Space charge, plasma potential and electric field distributions in HiPIMS discharges of varying configuration

    Science.gov (United States)

    Liebig, B.; Bradley, J. W.

    2013-08-01

    An electron-emitting (emissive) probe has been used to study the temporal and spatial distribution of the plasma potential during high-power impulse magnetron sputtering (HiPIMS) discharges with various substrate and magnetic field configurations. The average power was 700 W, with a repetition frequency of 100 Hz and pulse duration of 100 µs. Strongly negative plasma potentials exceeding -300 V and electric fields up to 10 kV m-1, caused by strong separation of charges with net charge carrier densities Δn of about 1014 m-3, were observed during the ignition of the discharge. The spatial distribution of the plasma potential in the stable stage of the discharge showed values consistently 5 V more negative for a floating substrate compared with a grounded one, so enhancing electron transport around the insulated substrate to grounded walls. However, this change in the electrical configuration of the plasma does not alter significantly the fraction of ionized sputtered particles (of about 30%) that can potentially reach the substrate. By changing the degree of unbalance of the sputtering source, we find a strong correlation between the electric field strength in the magnetic trap (created through charge separation) and the absolute value (and shape) of the magnetic field. For the more unbalanced magnetron, a flattening of the plasma potential structure (decrease in the axial electric field) was observed close to the target. Our findings show in principle that manipulation of the potential barrier close to the target through changing the magnetic field can regulate the proportion of sputtered and ionized species reaching the substrate.

  20. Canonical failure modes of real-time control systems: insights from cognitive theory

    Science.gov (United States)

    Wallace, Rodrick

    2016-04-01

    Newly developed necessary conditions statistical models from cognitive theory are applied to generalisation of the data-rate theorem for real-time control systems. Rather than graceful degradation under stress, automatons and man/machine cockpits appear prone to characteristic sudden failure under demanding fog-of-war conditions. Critical dysfunctions span a spectrum of phase transition analogues, ranging from a ground state of 'all targets are enemies' to more standard data-rate instabilities. Insidious pathologies also appear possible, akin to inattentional blindness consequent on overfocus on an expected pattern. Via no-free-lunch constraints, different equivalence classes of systems, having structure and function determined by 'market pressures', in a large sense, will be inherently unreliable under different but characteristic canonical stress landscapes, suggesting that deliberate induction of failure may often be relatively straightforward. Focusing on two recent military case histories, these results provide a caveat emptor against blind faith in the current path-dependent evolutionary trajectory of automation for critical real-time processes.

  1. Time-of-Flight Three Dimensional Neutron Diffraction in Transmission Mode for Mapping Crystal Grain Structures.

    Science.gov (United States)

    Cereser, Alberto; Strobl, Markus; Hall, Stephen A; Steuwer, Axel; Kiyanagi, Ryoji; Tremsin, Anton S; Knudsen, Erik B; Shinohara, Takenao; Willendrup, Peter K; da Silva Fanta, Alice Bastos; Iyengar, Srinivasan; Larsen, Peter M; Hanashima, Takayasu; Moyoshi, Taketo; Kadletz, Peter M; Krooß, Philipp; Niendorf, Thomas; Sales, Morten; Schmahl, Wolfgang W; Schmidt, Søren

    2017-08-25

    The physical properties of polycrystalline materials depend on their microstructure, which is the nano- to centimeter scale arrangement of phases and defects in their interior. Such microstructure depends on the shape, crystallographic phase and orientation, and interfacing of the grains constituting the material. This article presents a new non-destructive 3D technique to study centimeter-sized bulk samples with a spatial resolution of hundred micrometers: time-of-flight three-dimensional neutron diffraction (ToF 3DND). Compared to existing analogous X-ray diffraction techniques, ToF 3DND enables studies of samples that can be both larger in size and made of heavier elements. Moreover, ToF 3DND facilitates the use of complicated sample environments. The basic ToF 3DND setup, utilizing an imaging detector with high spatial and temporal resolution, can easily be implemented at a time-of-flight neutron beamline. The technique was developed and tested with data collected at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Complex (J-PARC) for an iron sample. We successfully reconstructed the shape of 108 grains and developed an indexing procedure. The reconstruction algorithms have been validated by reconstructing two stacked Co-Ni-Ga single crystals, and by comparison with a grain map obtained by post-mortem electron backscatter diffraction (EBSD).

  2. A new reasonable scenario to search for ER-alpha energy-time-position correlated sequences in a real time mode

    CERN Document Server

    Tsyganov, Y S

    2015-01-01

    A new real-time PC based algorithm and a compact C++ code to operate in a real-time mode with a 48x128 strip double side position sensitive large area silicon radiation detector Micron Semiconductors (UK) are developed and tested. Namely with this new approach it has become possible to provide the quick extraction of EVR-alpha correlated sequences in heavy ion induced complete fusion nuclear reactions. Specific attention is paid to the application of new CAMAC 4 M modules for charge particle position measurement during long- term experiments aimed to the synthesis of new superheavy nuclei. Some attention is paid to the different (combined) algorithm scenario to search for ER-alpha and alpha-alpha chains.

  3. A new reasonable scenario to search for ER-alpha energy-time-position correlated sequences in a real time mode

    Science.gov (United States)

    Tsyganov, Yu. S.

    2015-07-01

    A new real-time PC based algorithm and a compact C++ code to operate in a real-time mode with a 48 × 128 strip double side position sensitive large area silicon radiation detector Micron Semiconductors (UK) are developed and tested. Namely with this new approach it has become possible to provide the quick extraction of EVR-alpha correlated sequences in heavy ion induced complete fusion nuclear reactions. Specific attention is paid to the application of new CAMAC 4 M modules for charge particle position measurement during long-term experiments aimed to the synthesis of new superheavy nuclei. Some attention is paid to the different (combined) algorithm scenario to search for ER-alpha and alpha-alpha chains.

  4. CMOS time-to-digital converters for mixed-mode signal processing

    Directory of Open Access Journals (Sweden)

    Fei Yuan

    2014-04-01

    Full Text Available This study provides an in-depth review of the principles, architectures and design techniques of CMOS time-to-digital converters (TDCs. The classification of TDCs is introduced. It is followed by the examination of the parameters quantifying the performance of TDCs. Sampling TDCs including direct-counter TDCs, tapped delay-line TDCs, pulse-shrinking delay-line TDCs, cyclic pulse-shrinking TDCs, direct-counter TDCs with interpolation, vernier TDCs, flash TDCs, successive approximation TDCs and pipelined TDCs are studied and their pros and cons are compared. Noise-shaping TDCs that reduce in-band noise below technology limit are investigated. These TDCs include gated ring oscillator TDCs, switched ring oscillator TDCs, relaxation oscillator TDCs, ΔΣ TDCs and MASH TDCs. The performance of sampling and noise-shaping TDCs is compared. The direction of future research on TDCs is explored.

  5. Highly Integrated Mixed-Mode Electronics for the readout of Time Projection Chambers

    CERN Document Server

    França Santos, Hugo Miguel; Musa, Luciano

    Time Projection Chambers (TPCs) are one of the most prevalent particle trackers for high-energy physics experiments. Future planed TPCs for the International Linear Collider (ILC) and the Compact Linear Collider (CLIC) entail very high spatial resolution in large gas volumes, but impose low material budget for the end caps of the TPC cylinder. This constraint is not accomplished with the state-of-the-art front-end electronics because of its unsuited relatively large mass and of its associated water cooling system. To reach the required material budget, highly compact and power efficient dedicated TPC front-end electronics should be developed. This project aims at re-designing the different electronic elements with significant improvements in terms of performance, power efficiency and versatility, and developing an integrated circuit that merges all components of the front-end electronics. This chip ambitions a large volume production at low unitary cost and its employment in multiple detectors. The design of ...

  6. [THE FAILURE MODES AND EFFECTS ANALYSIS FACILITATES A SAFE, TIME AND MONEY SAVING OPEN ACCESS COLONOSCOPY SERVICE].

    Science.gov (United States)

    Gingold-Belfer, Rachel; Niv, Yaron; Horev, Nehama; Gross, Shuli; Sahar, Nadav; Dickman, Ram

    2017-04-01

    Failure modes and effects analysis (FMEA) is used for the identification of potential risks in health care processes. We used a specific FMEA - based form for direct referral for colonoscopy and assessed it for procedurerelated perforations. Ten experts in endoscopy evaluated and computed the entire referral process, modes of preparation for the endoscopic procedure, the endoscopic procedure itself and the discharge process. We used FMEA assessing for likelihood of occurrence, detection and severity and calculated the risk profile number (RPN) for each of the above points. According to the highest RPN results we designed a specific open access referral form and then compared the occurrence of colonic perforations (between 2010 and 2013) in patients who were referred through the open access arm (Group 1) to those who had a prior clinical consultation (non-open access, Group 2). Our experts in endoscopy (5 physicians and 5 nurses) identified 3 categories of failure modes that, on average, reached the highest RPNs. We identified 9,558 colonoscopies in group 1, and 12,567 in group 2. Perforations were identified in three patients from the open access group (1:3186, 0.03%) and in 10 from group 2 (1:1256, 0.07%) (p = 0.024). Direct referral for colonoscopy saved 9,558 pre-procedure consultations and the sum of $850,000. The FMEA tool-based specific referral form facilitates a safe, time and money saving open access colonoscopy service. Our form may be adopted by other gastroenterological clinics in Israel.

  7. Relationship between binder contents and mechanical properties of 17-4 ph stainless steel fabricated by PIM process and sintering

    Science.gov (United States)

    Khalil, K. A.; Kim, Sug Won

    2006-04-01

    Mechanical properties and microstructures of 17-4 ph stainless steel parts produced using different binder contents (powder loading) of powder injection molding (PIM) feedstock have been studied. The tensile and wear properties have been evaluated. Wear tests were conducted by a pin-on-disk tribometer, without lubricant, at different loads and sliding distance. SEM examination of the fracture sufaces revealed good particle bonding and a high ductile fracture surface for high powder loading. The surface fractures of the bars with higher powder loading show a closed porosity. High performance properties such as fully dense, ultimate tensile strength, hardness and wear resistance are obtained with high powder loading.

  8. Imaging of a Defect in Thin Plates Using the Time Reversal of Single Mode Lamb Wave: Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Hyun Jo; Lee, Jung Sik; Bae, Sung Min; Lee, Hyun Ki [Wonkwang University, Iksan (Korea, Republic of)

    2010-06-15

    This paper presents an analytical investigation for a baseline-free imaging of a defect in plate-like structures using the time-reversal of Lamb waves. We first consider the flexural wave (A0 mode) propagation in a plate containing a defect, and reception and time reversal process of the output signal at the receiver. The received output signal is then composed of two parts: a directly propagated wave and a scattered wave from the defect. The time reversal of these waves recovers the original input signal, and produces two additional side bands that contain the time-of-flight information on the defect location. One of the side band signals is then extracted as a pure defect signal. A defect localization image is then constructed from a beamforming technique based on the time-frequency analysis of the side band signal for each transducer pair in a network of sensors. The simulation results show that the proposed scheme enables the accurate, baseline-free detection of a defect, so that experimental studies are needed to verify the proposed method and to be applied to real structure

  9. Stability analysis and quasinormal modes of Reissner–Nordstrøm space-time via Lyapunov exponent

    Indian Academy of Sciences (India)

    PRADHAN PARTHAPRATIM

    2016-07-01

    We explicitly derive the proper-time (τ ) principal Lyapunov exponent (λp) and coordinate-time (t ) principal Lyapunov exponent $(\\lambda_c)$ for Reissner–Nordstrøm (RN) black hole (BH). We also compute their ratio. For RN space-time, it is shown that the ratio is $(\\lambda_{p}/\\lambda_{c}) = r_{0}/\\sqrt{r^{2}0 − 3Mr_{0} + 2Q^{2}}$ for time-like circulargeodesics and for Schwarzschild BH, it is $(\\lambda_{p}/\\lambda_{c}) = \\sqrt{r_{0}}/\\sqrt{r_{0} − 3M}. We further show that their ratio $\\lambda_{p}/\\lambda_{c}$ may vary from orbit to orbit. For instance, for Schwarzschild BH at the innermost stable circular orbit (ISCO), the ratio is $(\\lambda_{p}/\\lambda_{c})_{|rISCO}=6M = \\sqrt{2}$ and at marginally bound circular orbit (MBCO) the ratio is calculated to be $(\\lambda_{p}/\\lambda_{c})|_{rmb}=4M = 2$. Similarly, for extremal RN BH, the ratio at ISCO is $(\\lambda_{p}/\\lambda_{c})|_{rISCO}=4M = 2\\sqrt{2}/\\sqrt{3}$. We also further analyse the geodesic stability via this exponent. By evaluating the Lyapunov exponent, it is shown that in the eikonal limit, the real and imaginary parts of the quasinormal modes of RN BH is given by the frequency and instability time-scale of the unstable null circular geodesics.

  10. Probability of loss of assured safety in systems with multiple time-dependent failure modes.

    Energy Technology Data Exchange (ETDEWEB)

    Helton, Jon Craig; Pilch, Martin.; Sallaberry, Cedric Jean-Marie.

    2012-09-01

    Weak link (WL)/strong link (SL) systems are important parts of the overall operational design of high-consequence systems. In such designs, the SL system is very robust and is intended to permit operation of the entire system under, and only under, intended conditions. In contrast, the WL system is intended to fail in a predictable and irreversible manner under accident conditions and render the entire system inoperable before an accidental operation of the SL system. The likelihood that the WL system will fail to deactivate the entire system before the SL system fails (i.e., degrades into a configuration that could allow an accidental operation of the entire system) is referred to as probability of loss of assured safety (PLOAS). Representations for PLOAS for situations in which both link physical properties and link failure properties are time-dependent are derived and numerically evaluated for a variety of WL/SL configurations, including PLOAS defined by (i) failure of all SLs before failure of any WL, (ii) failure of any SL before failure of any WL, (iii) failure of all SLs before failure of all WLs, and (iv) failure of any SL before failure of all WLs. The effects of aleatory uncertainty and epistemic uncertainty in the definition and numerical evaluation of PLOAS are considered.

  11. Time-dependent Diffusion Coefficient and Conventional Diffusion Constant of Nanoparticles in Polymer Melts by Mode-coupling Theory

    Institute of Scientific and Technical Information of China (English)

    Xin-yu Lai; Nan-rong Zhao

    2013-01-01

    Time-dependent diffusion coefficient and conventional diffusion constant are calculated and analyzed to study diffusion of nanoparticles in polymer melts.A generalized Langevin equation is adopted to describe the diffusion dynamics.Mode-coupling theory is employed to calculate the memory kernel of friction.For simplicity,only microscopic terms arising from binary collision and coupling to the solvent density fluctuation are included in the formalism.The equilibrium structural information functions of the polymer nanocomposites required by mode-coupling theory are calculated on the basis of polymer reference interaction site model with Percus-Yevick closure.The effect of nanoparticle size and that of the polymer size are clarified explicitly.The structural functions,the friction kernel,as well as the diffusion coefficient show a rich variety with varying nanoparticle radius and polymer chain length.We find that for small nanoparticles or short chain polymers,the characteristic short time non-Markov diffusion dynamics becomes more prominent,and the diffusion coefficient takes longer time to approach asymptotically the conventional diffusion constant.This constant due to the microscopic contributions will decrease with the increase of nanoparticle size,while increase with polymer size.Furthermore,our result of diffusion constant from modecoupling theory is compared with the value predicted from the Stokes-Einstein relation.It shows that the microscopic contributions to the diffusion constant are dominant for small nanoparticles or long chain polymers.Inversely,when nanonparticle is big,or polymer chain is short,the hydrodynamic contribution might play a significant role.

  12. [Geognosy versus Geology: National Modes of Thought and Cultural Practices Concerning Space and Time in Competition].

    Science.gov (United States)

    Klemun, Marianne

    2015-09-01

    Natural science investigators at the end of the eighteenth century made use of conflicting labels to position their respective preferred fields of activity in the Earth sciences. This mania for labelling marked their break with natural science and the umbrella term 'mineralogy'. In this conflict situation of specialist classifications and explanations, two terms in particular were established: geognosy and geology, which covered the very promising project of research in the areas of the 'origin of the Earth' and the 'formation of the Earth'. These and the associated research goals were subsequently accorded a dazzling career. Proceeding from the conceptual core-meaning in the formation of terms und its semantic spectrum and conceptual shifts in a time of change, my study will look at the identity and heterogeneity functions of geology and geognosy. For whereas in French and English speaking countries the term geology came to be used exclusively (geology, géologie), this was avoided in German, particularly because the term geognosy was preferred. These national differences may be explained with reference to the different cultural and national styles of science: for example the social embedding of geology in the culture of the English gentleman or the French museum culture, and the close connection of 'German' geognosy to mining. A further starting point in the analysis of the double use of both geology and geognosy in German speaking countries until 1840 is provided by the different references to temporalization and spatialization of the two terms. And we should also include the practical implications and the epistemic requirements that were bound up with the defence of geognosy in the German speaking world.

  13. Fusion of product and process data: Batch-mode and real-time streaming

    Energy Technology Data Exchange (ETDEWEB)

    Vincent De Sapio; Spike Leonard

    1999-12-01

    In today's DP product realization enterprise it is imperative to reduce the design-to-fabrication cycle time and cost while improving the quality of DP parts (reducing defects). Much of this challenge resides in the inherent gap between the product and process worlds. The lack of seamless, bi-directional flow of information prevents true concurrency in the product realization world. This report addresses a framework for product-process data fusion to help achieve next generation product realization. A fundamental objective is to create an open environment for multichannel observation of process date, and subsequent mapping of that data onto product geometry. In addition to the sensor-based observation of manufacturing processes, model-based process data provides an important complement to empirically acquired data. Two basic groups of manufacturing models are process physics, and machine kinematics and dynamics. Process physics addresses analytical models that describe the physical phenomena of the process itself. Machine kinematic and dynamic models address the mechanical behavior of the processing equipment. As a secondary objective, an attempt has been made in this report to address part of the model-based realm through the development of an open object-oriented library and toolkit for machine kinematics and dynamics. Ultimately, it is desirable to integrate design definition, with all types of process data; both sensor-based and model-based. Collectively, the goal is to allow all disciplines within the product realization enterprise to have a centralized medium for the fusion of product and process data.

  14. Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Zhi-Fu; Hasvold, Lisa A.; Leverson, Joel D.; Han, Edward K.; Guan, Ran; Johnson, Eric F.; Stoll, Vincent S.; Stewart, Kent D.; Stamper, Geoff; Soni, Nirupama; Bouska, Jennifer J.; Luo, Yan; Sowin, Thomas J.; Lin, Nan-Horng; Giranda, Vincent S.; Rosenberg, Saul H.; Penning, Thomas D.; (Abbott)

    2010-02-19

    Pim-1, Pim-2, and Pim-3 are a family of serine/threonine kinases which have been found to be overexpressed in a variety of hematopoietic malignancies and solid tumors. Benzothienopyrimidinones were discovered as a novel class of Pim inhibitors that potently inhibit all three Pim kinases with subnanomolar to low single-digit nanomolar K{sub i} values and exhibit excellent selectivity against a panel of diverse kinases. Protein crystal structures of the bound Pim-1 complexes of benzothienopyrimidinones 3b (PDB code 3JYA), 6e (PDB code 3JYO), and 12b (PDB code 3JXW) were determined and used to guide SAR studies. Multiple compounds exhibited potent antiproliferative activity in K562 and MV4-11 cells with submicromolar EC{sub 50} values. For example, compound 14j inhibited the growth of K562 cells with an EC{sub 50} value of 1.7 {micro}M and showed K{sub i} values of 2, 3, and 0.5 nM against Pim-1, Pim-2, and Pim-3, respectively. These novel Pim kinase inhibitors efficiently interrupted the phosphorylation of Bad in both K562 and LnCaP-Bad cell lines, indicating that their potent biological activities are mechanism-based. The pharmacokinetics of 14j was studied in CD-1 mice and shown to exhibit bioavailability of 76% after oral dosing. ADME profiling of 14j suggested a long half-life in both human and mouse liver microsomes, good permeability, modest protein binding, and no CYP inhibition below 20 {micro}M concentration.

  15. Inflation and deflation timing of the AutoCAT 2 WAVE intra-aortic balloon pump using the autoPilot mode in a clinical setting.

    Science.gov (United States)

    Bakker, E W M; Visser, K; van der Wal, A; Kuiper, M A; Koopmans, M; Breedveld, R

    2012-09-01

    The primary goal of this observational clinical study was to register the occurrence of incorrect inflation and deflation timing of an intra-aortic balloon pump in autoPilot mode. The secondary goal was to identify possible causes of incorrect timing. During IABP assistance of 60 patients, every four hours a strip was printed with the IABP frequency set to 1:2. Strips were examined for timing discrepancies beyond 40 ms from the dicrotic notch (inflation) and the end of the diastolic phase (deflation). In this way, 320 printed strips were examined. A total of 52 strips (16%) showed incorrect timing. On 24 of these strips, the incorrect timing was called incidental, as it showed on only one or a few beats. The other 28 cases of erroneous timing were called consistent, as more than 50% of the beats on the strip showed incorrect timing. We observed arrhythmia in 69% of all cases of incorrect timing. When timing was correct, arrhythmia was found on 13 (5%) of 268 strips. A poor quality electrocardiograph (ECG) signal showed on 37% of all strips with incorrect timing and 11% of all strips with proper timing. We conclude that inflation and deflation timing of the IABP is not always correct when using the autoPilot mode. The quality of the ECG input signal and the occurrence of arrhythmia appear to be related to erroneous timing. Switching from autoPilot mode to operator mode may not always prevent incorrect timing.

  16. Zoom-TOFMS: addition of a constant-momentum-acceleration "zoom" mode to time-of-flight mass spectrometry.

    Science.gov (United States)

    Dennis, Elise A; Gundlach-Graham, Alexander W; Ray, Steven J; Enke, Christie G; Barinaga, Charles J; Koppenaal, David W; Hieftje, Gary M

    2014-11-01

    In this study, we demonstrate the performance of a new mass spectrometry concept called zoom time-of-flight mass spectrometry (zoom-TOFMS). In our zoom-TOFMS instrument, we combine two complementary types of TOFMS: conventional, constant-energy acceleration (CEA) TOFMS and constant-momentum acceleration (CMA) TOFMS to provide complete mass-spectral coverage as well as enhanced resolution and duty factor for a narrow, targeted mass region, respectively. Alternation between CEA- and CMA-TOFMS requires only that electrostatic instrument settings (i.e., reflectron and ion optics) and ion acceleration conditions be changed. The prototype zoom-TOFMS instrument has orthogonal-acceleration geometry, a total field-free distance of 43 cm, and a direct-current glow-discharge ionization source. Experimental results demonstrate that the CMA-TOFMS "zoom" mode offers resolution enhancement of 1.6 times over single-stage acceleration CEA-TOFMS. For the atomic mass range studied here, the maximum resolving power at full-width half-maximum observed for CEA-TOFMS was 1,610 and for CMA-TOFMS the maximum was 2,550. No difference in signal-to-noise (S/N) ratio was observed between the operating modes of zoom-TOFMS when both were operated at equivalent repetition rates. For a 10-kHz repetition rate, S/N values for CEA-TOFMS varied from 45 to 990 and from 67 to 10,000 for CMA-TOFMS. This resolution improvement is the result of a linear TOF-to-mass scale and the energy-focusing capability of CMA-TOFMS. Use of CMA also allows ions outside a given m/z range to be rejected by simple ion-energy barriers to provide a substantial improvement in duty factor.

  17. Characterization of timing jitter spectra in free-running mode-locked lasers with 340 dB dynamic range over 10 decades of Fourier frequency

    CERN Document Server

    Jung, Kwangyun

    2014-01-01

    We demonstrate a method that enables accurate timing jitter spectral density characterization of free-running mode-locked laser oscillators over more than 10-decade of Fourier frequency from mHz to tens MHz range. The method is based on analyzing both the input voltage noise to the slave laser and the output voltage noise from the balanced optical cross- correlator (BOC), when two mode-locked lasers are synchronized in repetition rate by the BOC. As a demonstration experiment, timing jitter spectrum of a free-running mode-locked Er-fiber laser with a dynamic range of >340 dB is measured over Fourier frequency ranging from 1 mHz to 38.5 MHz (Nyquist frequency). The demonstrated method can resolve different noise mechanisms that cause specific jitter characteristics in free-running mode-locked laser oscillators for a vast range of time scales from 1000-s.

  18. Time-resolved temperature measurements in a rapid compression machine using quantum cascade laser absorption in the intrapulse mode

    KAUST Repository

    Nasir, Ehson Fawad

    2016-07-16

    A temperature sensor based on the intrapulse absorption spectroscopy technique has been developed to measure in situ temperature time-histories in a rapid compression machine (RCM). Two quantum-cascade lasers (QCLs) emitting near 4.55μm and 4.89μm were operated in pulsed mode, causing a frequency "down-chirp" across two ro-vibrational transitions of carbon monoxide. The down-chirp phenomenon resulted in large spectral tuning (δν ∼2.8cm-1) within a single pulse of each laser at a high pulse repetition frequency (100kHz). The wide tuning range allowed the application of the two-line thermometry technique, thus making the sensor quantitative and calibration-free. The sensor was first tested in non-reactive CO-N2 gas mixtures in the RCM and then applied to cases of n-pentane oxidation. Experiments were carried out for end of compression (EOC) pressures and temperatures ranging 9.21-15.32bar and 745-827K, respectively. Measured EOC temperatures agreed with isentropic calculations within 5%. Temperature rise measured during the first-stage ignition of n-pentane is over-predicted by zero-dimensional kinetic simulations. This work presents, for the first time, highly time-resolved temperature measurements in reactive and non-reactive rapid compression machine experiments. © 2016 Elsevier Ltd.

  19. Development of Real-Time Dual-Display Handheld and Bench-Top Hybrid-Mode SD-OCTs

    Directory of Open Access Journals (Sweden)

    Nam Hyun Cho

    2014-01-01

    Full Text Available Development of a dual-display handheld optical coherence tomography (OCT system for retina and optic-nerve-head diagnosis beyond the volunteer motion constraints is reported. The developed system is portable and easily movable, containing the compact portable OCT system that includes the handheld probe and computer. Eye posterior chambers were diagnosed using the handheld probe, and the probe could be fixed to the bench-top cradle depending on the volunteers’ physical condition. The images obtained using this handheld probe were displayed in real time on the computer monitor and on a small secondary built-in monitor; the displayed images were saved using the handheld probe’s built-in button. Large-scale signal-processing procedures such as k-domain linearization, fast Fourier transform (FFT, and log-scaling signal processing can be rapidly applied using graphics-processing-unit (GPU accelerated processing rather than central-processing-unit (CPU processing. The Labview-based system resolution is 1,024 × 512 pixels, and the frame rate is 56 frames/s, useful for real-time display. The 3D images of the posterior chambers including the retina, optic-nerve head, blood vessels, and optic nerve were composed using real-time displayed images with 500 × 500 × 500 pixel resolution. A handheld and bench-top hybrid mode with a dual-display handheld OCT was developed to overcome the drawbacks of the conventional method.

  20. Discrete-Time Integral Sliding Mode Control with Disturbances Compensation and Reduced Chattering for Pv Grid-Connected Inverter

    Science.gov (United States)

    Meo, Santolo; Sorrentino, Vincenzo

    2015-03-01

    In the paper a new discrete-time integral sliding mode control (DISMC) with disturbances compensation and reduced chattering for grid-connected inverter is proposed for active and reactive power regulation. Differently by many SMC proposed in literature that have a time-continuous formulation in spite have been implemented with digital processor, the proposed DISMC is fully formulated in discrete-time, taking into account the effects introduced by a microprocessor-based implementation. As will be demonstrated such approach consents to reduce the chattering about the sliding manifold within a boundary layer of O(T2) thickness instead of O(T) (being T the sampling period of the control algorithm). Moreover it introduces a correction of the control vector which eliminates the influence of modeling error and external disturbances improving stability and robustness of the controlled system. Constant converter switching frequency is achieved by using space vector modulation, which eases the design of the ac harmonic filter. In the paper, after a detailed formalization of the proposed control algorithm, several numerical and experimental results on a three-phase grid-connected inverter prototype are shown, proving the effectiveness of the control strategy.

  1. Direct ion speciation analysis with ion-selective membranes operated in a sequential potentiometric/time resolved chronopotentiometric sensing mode.

    Science.gov (United States)

    Ghahraman Afshar, Majid; Crespo, Gastón A; Bakker, Eric

    2012-10-16

    Ion-selective membranes based on porous polypropylene membranes doped with an ionophore and a lipophilic cation-exchanger are used here in a new tandem measurement mode that combines dynamic electrochemistry and zero current potentiometry into a single protocol. Open circuit potential measurements yield near-nernstian response slopes in complete analogy to established ion-selective electrode methodology. Such measurements are well established to give direct information on the so-called free ion concentration (strictly, activity) in the sample. The same membrane is here also operated in a constant current mode, in which the localized ion depletion at a transition time is visualized by chronopotentiometry. This dynamic electrochemistry methodology gives information on the labile ion concentration in the sample. The sequential protocol is established on potassium and calcium ion-selective membranes. An increase of the ionophore concentration in the membrane to 180 mM makes it possible to determine calcium concentrations as high as 3 mM by chronopotentiometry, thereby making it possible to directly detect total calcium in undiluted blood samples. Recovery times after current perturbation depend on the current amplitude but can be kept to below 1 min for the polypropylene based ion-selective membranes studied here. Plasticized PVC as membrane material is less suited for this protocol, especially when the measurement at elevated concentrations is desired. An analysis of current amplitudes, transition times, and concentrations shows that the data are described by the Sand equation and that migration effects are insignificant. A numerical model describes the experimental findings with good agreement and gives guidance on the required selectivity in order to observe a well-resolved transition time and on the expected errors due to insufficient selectivity. The simulations suggest that the methodology compares well to that of open circuit potentiometry, despite giving

  2. Self-consistent long-time simulation of chirping energetic particle modes and abrupt large events in beam-driven JT-60U tokamak plasmas

    Science.gov (United States)

    Bierwage, A.; Shinohara, K.; Todo, Y.; Aiba, N.; Ishikawa, M.; Matsunaga, G.; Takechi, M.; Yagi, M.

    2016-10-01

    Recurring bursts of chirping Alfvén modes as well as so-called Abrupt Large Events (ALE) that were observed in JT-60U tokamak plasmas driven by negative-ion-based neutral beams (N-NB) are reproduced in first-principle simulations performed with an extended version of the hybrid code MEGA. This code simulates the interactions between gyrokinetic fast ions and magnetohydrodynamic (MHD) modes in the presence of a realistic fast ion source and collisions, so that it self-consistently captures dynamics across a wide range of time scales (0.01-100 ms). Detailed comparisons with experimental measurements are performed. On the long time scale (10-100 ms) the simulation reproduces ALEs with the associated avalanche-like transport of fast ions. ALEs are shown to occur when multiple modes with toroidal mode numbers n = 1 , 2 , 3 are excited to large amplitudes. On the meso time scale (1-10 ms), bursts of chirping modes are reproduced, which are shown to be n = 1 energetic particle modes (EPM). On the short time scale (0.01-0.1 ms), pulsations and phase jumps are reproduced, which we interpret as the result of beating between multiple resonant wave packets. JSPS Grant-in-Aid for Scientific Research (No. 25820443, 16K18341). NIFS Collaborative Research Program (NIFS12KNTT016).

  3. Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet

    Directory of Open Access Journals (Sweden)

    Chukwuemeka R. Nwokocha

    2014-01-01

    Full Text Available Context and Objectives: Cadmium (Cd toxicity leads to cell and organ damage, we comparatively examined the protection ability of different medicinal plants on Cd liver accumulation following different treatment interventions and modes of administration. Materials and Methods: Rats were fed either 7% w/w Zingiber officinale, 7% w/w Allium Sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow, while Cd (200 ppm was given in drinking water. Additives were administered together with (mode 1, a week after (mode 2 or a week before metal exposure (mode 3 for a period of six weeks. Cd liver was determined using AAS and compared using analysis of variance (ANOVA. Results: All additives significantly (P <0.5 reduced the accumulation of Cd in the liver. After adjusting for time and mode of administration, mean %protection for week 4 was significantly lower by 14.1% (P=0.02 from that for week 2 but the means did not differ with respect to additive used or mode of administration, no statistically significant interaction between modes of administration and either of additives used or time of administration in their respective relationships to percentage protection from Cd. Conclusion: Additives significantly reduced Cd accumulation through a reduction in absorption and enhancement of metal excretion.

  4. Robust Control of Industrial Hydraulic Cylinder Drives - with Special Reference to Sliding Mode- & Finite-Time Control

    DEFF Research Database (Denmark)

    Schmidt, Lasse

    performance, simple parameter design and robustness in the presence of uncertain parameters- and disturbances, the field of sliding mode control has been investigated. Especially high order sliding mode control methods have been studied, due the intriguing possibility of maintaining the main properties...... of sliding mode control but with continuous control inputs. The applicability of second order modes has been investigated, and modifications of such controls have been developed based on homogeneity principles in order to provide more suitable controllers for hydraulic systems, than conventional second order...... sliding mode types. Also, an extension of the second order sliding algorithm known as the twisting algorithm has been developed, with compensation of local equilibria, and even an arbitrary order sliding mode design has been considered in a future perspective. Experimental results reveal that the model...

  5. The hot prototype of the Pi-mode structure for LINAC4

    CERN Document Server

    Gerigk, F; Bourquin, P; Dallocchio, A; Favre, G; Geisser, J M; Gentini, L; Giguet, J M; Mathot, S; Polini, M; Pugnat, D; Riffaud, B; Sgobba, S; Tardy, T; Ugena Tirado, P; Vretenar, M

    2010-01-01

    The PIMS (Pi-Mode-Structure) cavities for Linac4 are made of 7 coupled cells operating in !-mode at a frequency of 352 MHz. The mechanical concept is derived from the 5-cell cavities used in the LEP machine, whereas cell length and coupling are adapted for proton acceleration in the range from 50 to 160 MeV. Linac4 will be the first machine to employ this type of cavities for low-beta protons. During the first years of operation the PIMS will be used at low duty cycle (0.1%) as part of the consolidated LHC proton injector complex. It is designed, however, to operate eventually in a high duty cycle (10%) proton injector, which could be used as proton front-end for neutrino or RIB applications. To prepare for the series construction of the 12 PIMS units the first cavity (102 MeV beam energy) has been designed and constructed at CERN, to be used as a hot prototype for RF tests and as a pre-series mechanical unit. In this paper we report on some of the design features, the construction experience, and first measu...

  6. Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide.

    Science.gov (United States)

    Speth, Jana; Speth, Clemens; Kaelen, Mendel; Schloerscheidt, Astrid M; Feilding, Amanda; Nutt, David J; Carhart-Harris, Robin L

    2016-04-01

    This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-controlled crossover study, incorporating intravenous administration of LSD (75 μg) and placebo (saline) prior to functional magnetic resonance imaging (fMRI). Six independent, blind judges analysed mentation reports acquired during structured interviews performed shortly after the functional magnetic resonance imaging (fMRI) scans (approximately 2.5 h post-administration). Within each report, specific linguistic references to mental spaces for the past, present and future were identified. Results revealed significantly fewer mental spaces for the past under LSD and this effect correlated with the general intensity of the drug's subjective effects. No differences in the number of mental spaces for the present or future were observed. Consistent with the previously proposed role of the default-mode network (DMN) in autobiographical memory recollection and ruminative thought, decreased resting-state functional connectivity (RSFC) within the DMN correlated with decreased mental time travel to the past. These results are discussed in relation to potential therapeutic applications of LSD and related psychedelics, e.g. in the treatment of depression, for which excessive reflection on one's past, likely mediated by DMN functioning, is symptomatic.

  7. Real-time, mixed-mode computing architecture for waveform-resolved lidar systems with total propagated uncertainty

    Science.gov (United States)

    Ortman, Robert L.; Carr, Domenic A.; James, Ryan; Long, Daniel; O'Shaughnessy, Matthew R.; Valenta, Christopher R.; Tuell, Grady H.

    2016-05-01

    We have developed a prototype real-time computer for a bathymetric lidar capable of producing point clouds attributed with total propagated uncertainty (TPU). This real-time computer employs a "mixed-mode" architecture comprised of an FPGA, CPU, and GPU. Noise reduction and ranging are performed in the digitizer's user-programmable FPGA, and coordinates and TPU are calculated on the GPU. A Keysight M9703A digitizer with user-programmable Xilinx Virtex 6 FPGAs digitizes as many as eight channels of lidar data, performs ranging, and delivers the data to the CPU via PCIe. The floating-point-intensive coordinate and TPU calculations are performed on an NVIDIA Tesla K20 GPU. Raw data and computed products are written to an SSD RAID, and an attributed point cloud is displayed to the user. This prototype computer has been tested using 7m-deep waveforms measured at a water tank on the Georgia Tech campus, and with simulated waveforms to a depth of 20m. Preliminary results show the system can compute, store, and display about 20 million points per second.

  8. Real Time Cardan Shaft State Estimation of High-Speed Train Based on Ensemble Empirical Mode Decomposition

    Directory of Open Access Journals (Sweden)

    Cai Yi

    2015-01-01

    Full Text Available Due to the special location and structure of transmission system on high-speed train named CRH5, dynamic unbalance state of the cardan shaft will pose a threat to the train servicing safety, so effective methods that test the cardan shaft operating information and estimate the performance state in real time are needed. In this study a useful estimation method based on ensemble empirical mode decomposition (EEMD is presented. By using this method, time-frequency characteristic of cardan shaft can be extracted effectively by separating the gearbox vibration acceleration data. Preliminary analysis suggests that the pinions rotating vibration separated from gearbox vibration by EEMD can be used as important assessment basis to estimate cardan shaft state. With two sets gearbox vibration signals collected from the in-service train at different running speed, the comparative analysis verifies that the proposed method has high effectiveness for cardan-shaft state estimate. Of course, it needs further research to quantify the performance state of cardan shaft based on this method.

  9. Time-perception network and default mode network are associated with temporal prediction in a periodic motion task

    Directory of Open Access Journals (Sweden)

    Fabiana Mesquita Carvalho

    2016-06-01

    Full Text Available The updating of prospective internal models is necessary to accurately predict future observations. Uncertainty-driven internal model updating has been studied using a variety of perceptual paradigms, and have revealed engagement of frontal and parietal areas. In a distinct literature, studies on temporal expectations have also characterized a time-perception network, which relies on temporal orienting of attention. However, the updating of prospective internal models is highly dependent on temporal attention, since temporal attention must be reoriented according to the current environmental demands. In this study we used fMRI to evaluate to what extend the continuous manipulation of temporal prediction would recruit update-related areas and the time-perception network areas. We developed an exogenous temporal task that combines rhythm cueing and time-to-contact principles to generate implicit temporal expectation. Two patterns of motion were created: periodic (simple harmonic oscillation and non-periodic (harmonic oscillation with variable acceleration. We found that non-periodic motion engaged the exogenous temporal orienting network, which includes the ventral premotor and inferior parietal cortices, and the cerebellum, as well as the presupplementary motor area, which has previously been implicated in internal model updating, and the motion-sensitive area MT+. Interestingly, we found a right-hemisphere preponderance suggesting the engagement of explicit timing mechanisms. We also show that the periodic motion condition, when compared to the non-periodic motion, activated a particular subset of the default-mode network (DMN midline areas, including the left dorsomedial prefrontal cortex, anterior cingulate cortex, and bilateral posterior cingulate cortex/precuneus. It suggests that the DMN plays a role in processing contextually expected information and supports recent evidence that the DMN may reflect the validation of prospective internal

  10. Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

    Science.gov (United States)

    Andreoli, Mirko; Persico, Marco; Kumar, Ajay; Orteca, Nausicaa; Kumar, Vineet; Pepe, Antonella; Mahalingam, Sakkarapalayam; Alegria, Antonio E; Petrella, Lella; Sevciunaite, Laima; Camperchioli, Alessia; Mariani, Marisa; Di Dato, Antonio; Novellino, Ettore; Scambia, Giovanni; Malhotra, Sanjay V; Ferlini, Cristiano; Fattorusso, Caterina

    2014-10-09

    Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing the incorporation of the GBP1 GTPase into microtubules. Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a signaling pathway that induces resistance to paclitaxel. Therefore, the inhibition of the GBP1:PIM1 interaction could potentially revert resistance to paclitaxel. A panel of 44 4-azapodophyllotoxin derivatives was screened in the NCI-60 cell panel. The result is that 31 are active and the comparative analysis demonstrated specific activity in paclitaxel-resistant cells. Using surface plasmon resonance, we were able to prove that NSC756093 is a potent in vitro inhibitor of the GBP1:PIM1 interaction and that this property is maintained in vivo in ovarian cancer cells resistant to paclitaxel. Through bioinformatics, molecular modeling, and mutagenesis studies, we identified the putative NSC756093 binding site at the interface between the helical and the LG domain of GBP1. According to our results by binding to this site, the NSC756093 compound is able to stabilize a conformation of GBP1 not suitable for binding to PIM1.

  11. Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection

    Directory of Open Access Journals (Sweden)

    Yan B.

    2006-01-01

    Full Text Available We have studied the molecular mechanism and signal transduction of pim-1, an oncogene encoding a serine-threonine kinase. This is a true oncogene which prolongs survival and inhibits apoptosis of hematopoietic cells. In order to determine whether the effects of Pim-1 occur by regulation of the mitogen-activated protein kinase pathway, we used a transcriptional reporter assay by transient co-transfection as a screening method. In this study, we found that Pim-1 inhibited the Elk-1 and NFkappaB transcriptional activities induced by activation of the mitogen-activated protein kinase cascade in reporter gene assays. However, Western blots showed that the induction of Elk-1-regulated expression of endogenous c-Fos was not affected by Pim-1. The phosphorylation and activation of neither Erk1/2 nor Elk-1 was influenced by Pim-1. Also, in the gel shift assay, the pattern of endogenous NFkappaB binding to its probe was not changed in any manner by Pim-1. These data indicate that Pim-1 does not regulate the activation of Erk1/2, Elk-1 or NFkappaB. These contrasting results suggest a pitfall of the transient co-transfection reporter assay in analyzing the regulation of transcription factors outside of the chromosome context. It ensures that results from reporter gene expression assay should be verified by study of endogenous gene expression.

  12. A Practical and Robust Execution Time-Frame Procedure for the Multi-Mode Resource-Constrained Project Scheduling Problem with Minimal and Maximal Time Lags

    Directory of Open Access Journals (Sweden)

    Angela Hsiang-Ling Chen

    2016-09-01

    Full Text Available Modeling and optimizing organizational processes, such as the one represented by the Resource-Constrained Project Scheduling Problem (RCPSP, improve outcomes. Based on assumptions and simplification, this model tackles the allocation of resources so that organizations can continue to generate profits and reinvest in future growth. Nonetheless, despite all of the research dedicated to solving the RCPSP and its multi-mode variations, there is no standardized procedure that can guide project management practitioners in their scheduling tasks. This is mainly because many of the proposed approaches are either based on unrealistic/oversimplified scenarios or they propose solution procedures not easily applicable or even feasible in real-life situations. In this study, we solve a more true-to-life and complex model, Multimode RCPSP with minimal and maximal time lags (MRCPSP/max. The complexity of the model solved is presented, and the practicality of the proposed approach is justified depending on only information that is available for every project regardless of its industrial context. The results confirm that it is possible to determine a robust makespan and to calculate an execution time-frame with gaps lower than 11% between their lower and upper bounds. In addition, in many instances, the solved lower bound obtained was equal to the best-known optimum.

  13. Towards low timing phase noise operation in fiber lasers mode locked by graphene oxide and carbon nanotubes at 1.5 µm.

    Science.gov (United States)

    Wu, Kan; Li, Xiaohui; Wang, Yonggang; Wang, Qi Jie; Shum, Perry Ping; Chen, Jianping

    2015-01-12

    We investigate the timing phase noise of fiber lasers mode locked by graphene oxide (GO) and carbon nanotubes (CNTs), respectively, integrated in a linear cavity fiber laser in the reflecting operation. Due to the shorter decay time of the GO and CNTs, weaker slow saturable absorber effects are expected and mode-locked lasers based on these two saturable absorbers exhibit low excess timing phase noise coupled from the laser intensity noise. Compared with a reference laser mode locked by semiconductor saturable absorber mirror (SESAM), GO based laser obtains a timing phase noise reduction of 7 dB at 1 kHz and a timing jitter reduction of 45% experimentally whereas CNTs based laser obtains a timing phase noise reduction of 3 dB and a timing jitter reduction of 29%. This finding suggests that saturable absorbers with short decay time have the potential for achieving mode locking operation with low timing phase noise, which is important for applications including frequency metrology, high-precision optical sampling, clock distribution and optical sensing.

  14. Performance of a GM tube based environmental dose rate monitor operating in the Time-To-Count mode

    Energy Technology Data Exchange (ETDEWEB)

    Zickefoose, J.; Kulkarni, T.; Martinson, T.; Phillips, K.; Voelker, M. [Canberra Industries Inc. (United States)

    2015-07-01

    The events at the Fukushima Daiichi power plant in the aftermath of a natural disaster underline the importance of a large array of networked environmental monitors to cover areas around nuclear power plants. These monitors should meet a few basic criteria: have a uniform response over a wide range of gamma energies, have a uniform response over a wide range of incident angles, and have a large dynamic range. Many of these criteria are met if the probe is qualified to the international standard IEC 60532 (Radiation protection instrumentation - Installed dose rate meters, warning assemblies and monitors - X and gamma radiation of energy between 50 keV and 7 MeV), which specifically deals with energy response, angle of incidence, dynamic range, response time, and a number of environmental characteristics. EcoGamma is a dual GM tube environmental gamma radiation monitor designed specifically to meet the requirements of IEC 60532 and operate in the most extreme conditions. EcoGamma utilizes two energy compensated GM tubes operating with a Time-To-Count (TTC) collection algorithm. The TTC algorithm extends the lifetime and range of a GM tube significantly and allows the dual GM tube probe to achieve linearity over approximately 10 decades of gamma dose rate (from the Sv/hr range to 100 Sv/hr). In the TTC mode of operation, the GM tube is not maintained in a biased condition continuously. This is different from a traditional counting system where the GM tube is held at a constant bias continuously and the total number of strikes that the tube registers are counted. The traditional approach allows for good sensitivity, but does not lend itself to a long lifetime of the tube and is susceptible to linearity issues at high count rates. TTC on the other hand only biases the tube for short periods of time and in effect measures the time between events, which is statistically representative of the total strike rate. Since the tube is not continually biased, the life of the tube

  15. Proposal for a New Test of the Time Independence Of The Fine Structure Constant, alpha, Using Orthogonally Polarised Whispering Gallery Modes in a Single Sapphire Resonator

    CERN Document Server

    Tobar, M E; Tobar, Michael Edmund; Hartnett, John Gideon

    2003-01-01

    A new experiment to test for the time independence of the fine structure constant, alpha, is proposed. The experiment utilizes orthogonally polarized Transverse Electric and Transverse Magnetic Whispering Gallery Modes in a single sapphire resonator tuned to similar frequencies. When configured as a dual mode sapphire clock, we show that the anisotropy of sapphire makes it is possible to undertake a sensitive measurement from the beat frequency between the two modes. At infrared frequencies this is possible due to the different effect of the lowest phonon frequency on the two orthogonally polarized modes. At microwave frequencies we show that the phonon effect is too small. We show that the Electron Spin Resonance of paramagnetic impurities (such as Cr3+) in the lattice effects only one polarization with an alpha^6 dependence. This enables an enhancement of the sensitivity to temporal changes in a at microwave frequencies.

  16. An Assessment of the Academic Achievement of Students in Two Modes of Part-time Programme in Nigeria

    Directory of Open Access Journals (Sweden)

    Kola Adeyemi

    2005-07-01

    Full Text Available This study analyses the academic achievement of students enrolled in part-times studies at on-campus and outreach centres at three dual-mode Nigerian universities, during the 1996/97 to 1998/ 99 academic years. Research subjects in this study were examination and record officers employed by on-campus and outreach institutions. A checklist was prepared to collect students’ grades; these checklists were then transcribed into grade points (GPAs for data collection purposes. Simple percentage mean (x and t-test statistic were used for data analysis. Interviews were also conducted with key stakeholders to add qualitative context to the quantitative data collected. This study shows that there was significant difference in the academic performance of students enrolled in the on-campus versus outreach-based, part-time programmes in selected disciplines. Also the average mean (x performance of students enrolled in the on-campus programme was higher than those students enrolled in the outreach centres. Based on the findings of this study, it is recommended that the government provide adequate funding to increase access individuals seeking higher education in Nigeria. The establishment of functional Open University system is also recommended to provide students with distant learning opportunities and likewise increase access. Several quality improvements are likewise recommended: the use of modern information technology for instructional delivery, recruitment of skilled teachers, improved teaching/ learning facilities, and strict adherence to standardized student admission requirements as specified by the National Universities Commission (NUC. We wrap up with practical suggestions, such as providing orientation sessions for outreach students to learn practical skills such as how to access library materials.

  17. Comparison of measurements from optical CMM and focus-variation microscope of a μPIM mechanical part

    DEFF Research Database (Denmark)

    Quagliotti, Danilo; Salaga, Jacek; Tosello, Guido

    2016-01-01

    Two sets of 5 green and 5 sintered mechanical parts, manufactured by micro powder injection moulding (μPIM), were measured using an optical coordinate measuring machine (OCMM) and a focus-variation microscope (FVM). The examined features of size, including diameter, radii and distances, span...... in the range of (10-1–101) mm. Comparing the corresponding measurements from the two instruments, a relative maximum deviation of 8 % was found for the linear dimensions of the green parts and a relative maximum deviation of 6 % for the ones of the sintered parts. The maximum relative deviation of the radii...... was 17 % for the green parts and 30 % for the sintered parts (relative deviations have been evaluated considering focus-variation measurements as reference).OCMM showed some problems in the detection of the smallest dimensional features (above all radii) where the presence of defects on the edges, quite...

  18. Non-relativistic Nambu-Goldstone modes associated with spontaneously broken space-time and internal symmetries

    CERN Document Server

    Kobayashi, Michikazu

    2014-01-01

    We show that a momentum operator of a translational symmetry may not commute with an internal symmetry operator in the presence of a topological soliton in non-relativistic theories. As a striking consequence, there appears a coupled Nambu-Goldstone mode with a quadratic dispersion consisting of translational and internal zero modes in the vicinity of a domain wall in an O(3) sigma model, a magnetic domain wall in ferromagnets with an easy axis.

  19. Parametrizing the time variation of the `surface term' of stellar p-mode frequencies: application to helioseismic data

    Science.gov (United States)

    Howe, R.; Basu, S.; Davies, G. R.; Ball, W. H.; Chaplin, W. J.; Elsworth, Y.; Komm, R.

    2017-02-01

    The solar-cycle variation of acoustic mode frequencies has a frequency dependence related to the inverse mode inertia. The discrepancy between model predictions and measured oscillation frequencies for solar and solar-type stellar acoustic modes includes a significant frequency-dependent term known as the surface term, which is also related to the inverse mode inertia. We parametrize both the surface term and the frequency variations for low-degree solar data from Birmingham Solar-Oscillations Network (BiSON) and medium-degree data from the Global Oscillations Network Group (GONG) using the mode inertia together with cubic and inverse frequency terms. We find that for the central frequency of rotationally split multiplets, the cubic term dominates both the average surface term and the temporal variation, but for the medium-degree case, the inverse term improves the fit to the temporal variation. We also examine the variation of the even-order splitting coefficients for the medium-degree data and find that, as for the central frequency, the latitude-dependent frequency variation, which reflects the changing latitudinal distribution of magnetic activity over the solar cycle, can be described by the combination of a cubic and an inverse function of frequency scaled by inverse mode inertia. The results suggest that this simple parametrization could be used to assess the activity-related frequency variation in solar-like asteroseismic targets.

  20. Confirmation of simultaneous p and g mode excitation in HD 8801 and Gamma Peg from time-resolved multicolour photometry of six candidate "hybrid" pulsators

    CERN Document Server

    Handler, G

    2009-01-01

    We carried out a multi-colour time-series photometric study of six stars claimed as "hybrid" p and g mode pulsators in the literature. Gamma Peg was confirmed to show short-period oscillations of the Beta Cep type and simultaneous long-period pulsations typical of Slowly Pulsating B (SPB) stars. From the measured amplitude ratios in the Stromgren uvy passbands, the stronger of the two short period pulsation modes was identified as radial; the second is l=1. Three of the four SPB-type modes are most likely l=1 or 2. Comparison with theoretical model calculations suggests that Gamma Peg is either an 8.5 solar mass radial fundamental mode pulsator or a 9.6 solar mass first radial overtone pulsator. HD 8801 was corroborated as a "hybrid" Delta Sct Gamma Dor star; four pulsation modes of the Gamma Dor type were detected, and two modes of the Delta Sct type were confirmed. Two pulsational signals between the frequency domains of these two known classes of variables were confirmed and another was newly detected. The...

  1. Systematic investigation of low-lying dipole modes using the canonical-basis time-dependent Hartree-Fock-Bogoliubov theory

    CERN Document Server

    Ebata, Shuichiro; Inakura, Tsunenori

    2014-01-01

    Systematic investigations of the electric dipole (E1) modes of excitation are performed using the canonical-basis time-dependent Hartree-Fock-Bogoliubov (Cb-TDHFB) theory. The Cb-TDHFB is able to describe dynamical pairing correlations in excited states of nuclear systems. We apply the method to the real-time calculation of linear response in even-even nuclei with Skyrme functionals. Effects of shell structure, neutron skin, deformation, and neutron chemical potential (separation energy) are studied in a systematic way. This reveals a number of characteristic features of the low-energy E1 modes. We also find a universal behavior in the low-energy E1 modes for heavy neutron-rich isotopes, which suggests the emergence of decoupled E1 peaks beyond N = 82.

  2. The impact of the time interval between two successive deliveries in an obstetric unit in terms of the mode of each delivery and the rate of perinatal mortality.

    Science.gov (United States)

    Stein, Werner; Hawighorst, Thomas; Wenzlaff, Paul; Emons, Günter

    2012-01-01

    To analyze the relationship of the time interval between two deliveries, done by one obstetric team, on the delivery mode of the subsequent birth; to define the length of this interval; and to evaluate this time interval as a risk factor for increased perinatal mortality in a population-based cohort. All singleton deliveries at ≥ 24 weeks' gestation in Lower Saxony, Germany, between 2001 and 2005 (a total of 317,663 deliveries including 402 cases of perinatal mortality) were analyzed. The mode of the previous and the subsequent delivery, the time interval between the two deliveries, the time of birth, the hospital volume, and the existence of an affiliated neonatal ward were investigated. When the first vaginal delivery was deliveries following an earlier vaginal birth and occurring within time interval between two deliveries in an obstetric unit constitutes an independent risk factor for perinatal mortality.

  3. Command and Control Modes for Attack of Time-Sensitive Targets%时间敏感目标打击指挥控制模式

    Institute of Scientific and Technical Information of China (English)

    端木竹筠; 闫晶晶

    2012-01-01

    An attack chain model of time-sensitive target based on several decision variables and constrains is developed. Three command and control modes for the attack of time-sensitive targets, including decider-led mode, sensor-led mode and shooter-led mode are discussed based on optimization of the attack chain model. Then, the battle condition and factors affecting the efficiency for each mode are analyzed.%通过引入决策变量和约束条件对时间敏感目标(简称时敏目标)打击链进行了模型描述,并根据模型的优化问题引入了时敏目标打击的指挥控制模式,包括决策者主导模式、传感器主导模式以及射手主导模式,分析了每种模式适合的作战情形以及作战效能的影响因素。

  4. Computation of Pacemakers Immunity to 50 Hz Electric Field: Induced Voltages 10 Times Greater in Unipolar Than in Bipolar Detection Mode

    Directory of Open Access Journals (Sweden)

    Cihan Gercek

    2017-03-01

    Full Text Available Thisstudy aims to compute 50 Hz electric field interferences on pacemakers for diverse lead configurations and implantation positions. Induced phenomena in a surface-based virtual human model (standing male grounded with arms closed, 2 mm resolution are computed for vertical exposure using CST EM® 3D software, with and without an implanted pacemaker. Induced interference voltages occurring on the pacemaker during exposure are computed and the results are discussed. The bipolar mode covers 99% of the implanted pacing leads in the USA and Europe, according to statistics. The tip-to-ring distance of a lead may influence up to 46% of the induced voltage. In bipolar sensing mode, right ventricle implantation has a 41% higher induced voltage than right atrium implantation. The induced voltage is in average 10 times greater in unipolar mode than in bipolar mode, when implanted in the right atrium or right ventricle. The electric field threshold of interference for a bipolar sensing mode in the worst case setting is 7.24 kV·m−1, and 10 times higher for nominal settings. These calculations will be completed by an in vitro study.

  5. Parametrizing the time-variation of the "surface term" of stellar p-mode frequencies: application to helioseismic data

    CERN Document Server

    Howe, R; Davies, G R; Ball, W H; Chaplin, W J; Elsworth, Y; Komm, R

    2016-01-01

    The solar-cyle variation of acoustic mode frequencies has a frequency dependence related to the inverse mode inertia. The discrepancy between model predictions and measured oscillation frequencies for solar and solar-type stellar acoustic modes includes a significant frequency-dependent term known as the surface term that is also related to the inverse mode inertia. We parametrize both the surface term and the frequency variations for low-degree solar data from Birmingham Solar-Oscillations Network (BiSON) and medium-degree data from the Global Oscillations Network Group (GONG) using the mode inertia together with cubic and inverse frequency terms. We find that for the central frequency of rotationally split multiplets the cubic term dominates both the average surface term and the temporal variation, but for the medium-degree case the inverse term improves the fit to the temporal variation. We also examine the variation of the even-order splitting coefficients for the medium-degree data and find that, as for ...

  6. Finite-time convergent continuous control design based on sliding mode algorithms with application to a hydraulic drive

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben Ole; Pedersen, Henrik C.

    2014-01-01

    Sliding modes impose strong robustness toward parametric plant uncertainties and disturbances and provide for accurate tracking performance in control systems. However, in physical systems the application of sliding modes may give rise to undesirable chattering of the control signal due to actuator...... dynamics, possible excitation of unmodelled dynamics and structural resonant modes of load systems, etc. This may be avoided by application of smoothing functions imposing boundary layers on the control constraint, or by carrying out the design in relation to the control derivative. However, such boundary...... layers introduce additional design parameters and actuator dynamics may not allow the desired control accuracy to be reached. In this paper continuous controllers are proposed, with the designs taking their offset in some well-known sliding controllers. The proposed controllers preserve the finite...

  7. Mode of Delivery according to Leisure Time Physical Activity before and during Pregnancy: A Multicenter Cohort Study of Low-Risk Women.

    Science.gov (United States)

    Nielsen, Emilie Nor; Andersen, Per Kragh; Hegaard, Hanne Kristine; Juhl, Mette

    2017-01-01

    Objectives. To examine the association between maternal leisure time physical activity and mode of delivery. Study Design. Population-based multicentre cohort. From the Danish Dystocia Study, we included 2,435 nulliparous women, who delivered a singleton infant in cephalic presentation at term after spontaneous onset of labor in 2004-2005. We analysed mode of delivery according to self-reported physical activity at four stages, that is, the year before pregnancy and during first, second, and third trimester, in logistic regression models. Further, we combined physical activity measures at all four stages in one variable for a proportional odds model for cumulative logits. Main Outcome Measures. Mode of delivery (emergency caesarean section; vacuum extractor; spontaneous vaginal delivery). Results. The odds of emergency caesarean section decreased with increasing levels of physical activity with statistically significant trends at all four time stages except the third trimester. This tendency was confirmed in the proportional odds model showing 28% higher odds of a more complicated mode of delivery among women with a low activity level compared to moderately active women. Conclusions. We found increasing leisure time physical activity before and during pregnancy associated with a less complicated delivery among low-risk, nulliparous women.

  8. Rigorous study of low-complexity adaptive space-time block-coded MIMO receivers in high-speed mode multiplexed fiber-optic transmission links using few-mode fibers

    Science.gov (United States)

    Weng, Yi; He, Xuan; Wang, Junyi; Pan, Zhongqi

    2017-01-01

    Spatial-division multiplexing (SDM) techniques have been purposed to increase the capacity of optical fiber transmission links by utilizing multicore fibers or few-mode fibers (FMF). The most challenging impairments of SDMbased long-haul optical links mainly include modal dispersion and mode-dependent loss (MDL), whereas MDL arises from inline component imperfections, and breaks modal orthogonality thus degrading the capacity of multiple-inputmultiple- output (MIMO) receivers. To reduce MDL, optical approaches include mode scramblers and specialty fiber designs, yet these methods were burdened with high cost, yet cannot completely remove the accumulated MDL in the link. Besides, space-time trellis codes (STTC) were purposed to lessen MDL, but suffered from high complexity. In this work, we investigated the performance of space-time block-coding (STBC) scheme to mitigate MDL in SDM-based optical communication by exploiting space and delay diversity, whereas weight matrices of frequency-domain equalization (FDE) were updated heuristically using decision-directed recursive-least-squares (RLS) algorithm for convergence and channel estimation. The STBC was evaluated in a six-mode multiplexed system over 30-km FMF via 6×6 MIMO FDE, with modal gain offset 3 dB, core refractive index 1.49, numerical aperture 0.5. Results show that optical-signal-to-noise ratio (OSNR) tolerance can be improved via STBC by approximately 3.1, 4.9, 7.8 dB for QPSK, 16- and 64-QAM with respective bit-error-rates (BER) and minimum-mean-square-error (MMSE). Besides, we also evaluate the complexity optimization of STBC decoding scheme with zero-forcing decision feedback (ZFDF) equalizer by shortening the coding slot length, which is robust to frequency-selective fading channels, and can be scaled up for SDM systems with more dynamic channels.

  9. STUDY OF PRIOR PREPAREDNESS AND AWARENESS REGARDING THE MBBS COURSE AMONGST FIRST YEAR STUDENTS ADMITTED AT RURAL MEDICAL COLLEGE, OF PIMS-DU, LONI

    OpenAIRE

    Padmanabhan P, Kunkulol R, Jangle SN

    2015-01-01

    Background: Adolescents in India choose career in medicine under the influence and pressure from parents, family members, peers and external sources. There are no measures taken to study whether these medical students understand the demands and priorities of a career in medicine once they decide to choose it. Hence the study was undertaken at PIMS-DU with Ist year MBBS students as participants. Aims: 1) Assess the factors influencing the choice of MBBS. 2) Analyze the prior knowledge and awar...

  10. Extraction of Gold(III) from Hydrochloric Acid Solutions with a PVC-based Polymer Inclusion Membrane (PIM) Containing Cyphos(®) IL 104.

    Science.gov (United States)

    Bonggotgetsakul, Ya Ya Nutchapurida; Cattrall, Robert W; Kolev, Spas D

    2015-12-08

    Poly(vinyl chloride) (PVC) based polymer inclusion membranes (PIMs), with different concentrations of Cyphos® IL 104 as the membrane extractant/carrier, were studied for their ability to extract Au(III) from hydrochloric acid solutions. Some of the PIMs also contained one of the following plasticizers or modifiers: 2-nitrophenyloctyl ether, dioctylphthalate, 1-dodecanol, 1-tetradecanol, or tri(2-ethylhexyl) phosphate. The best performance, in terms of extraction rate and amount of Au(III) extracted, was exhibited by a PIM consisting of 25 wt% Cyphos(®) IL 104, 5 wt% 1-dodecanol, and 70 wt% PVC. An almost complete back-extraction of the Au(III) extracted from this membrane was achieved by using a 0.10 mol L(-1) Na₂SO₃ receiver solution at pH 8. The stoichiometry of the extracted Au(III)/Cyphos® IL 104 adduct was determined as [P]⁺ [AuCl₄](-) H⁺ [PO₂](-) where [P]⁺ and [PO₂](-) represent trihexyl(tetradecyl) phosphonium and bis(2,4,4-trimethylpentyl) phosphinate ions, respectively. Back-extraction of Au(III) is suggested to occur by reduction of Au(III) to Au(I), with the formation of the species [Au(SO₃)₂](3-) in the aqueous receiver solution. Loss of 1-dodecanol from the newly developed PIM to the aqueous solutions in contact with it was observed, which indicated that this membrane was suitable for single use in the efficient recovery of Au(III) from hydrochloric acid solutions of electronic scrap or recycled jewelry.

  11. Time-varying sliding-coefficient-based decoupled terminal sliding-mode control for a class of fourth-order systems.

    Science.gov (United States)

    Bayramoglu, Husnu; Komurcugil, Hasan

    2014-07-01

    A time-varying sliding-coefficient-based decoupled terminal sliding mode control strategy is presented for a class of fourth-order systems. First, the fourth-order system is decoupled into two second-order subsystems. The sliding surface of each subsystem was designed by utilizing time-varying coefficients. Then, the control target of one subsystem to another subsystem was embedded. Thereafter, a terminal sliding mode control method was utilized to make both subsystems converge to their equilibrium points in finite time. The simulation results on the inverted pendulum system demonstrate that the proposed method exhibits a considerable improvement in terms of a faster dynamic response and lower IAE and ITAE values as compared with the existing decoupled control methods.

  12. Statistical propeties of a single-mode laser driven by additive and multiplicative coloured noises with a coloured cross-correlation for different correlation times

    Institute of Scientific and Technical Information of China (English)

    梁贵云; 曹力; 张莉; 吴大进

    2003-01-01

    We study a system for a single-mode laser driven by additive and multiplicative coloured noises with a coloured cross-correlation. The analytical expression of the stationary intensity distribution (SID) for the laser is derived in the case of three different correlation times. The influences of each stochastic parameter on the SID are discussed, the the skewness, λ3(O) of the single-mode laser are investigated. We find that there are colourful phase transitions for the SID above a threshold, and re-entrant transitions induced by the "colour" of the additive noises. Further research of the not only increases with the additive noise correlation time τ2 and the cross-correlation time τs, but also the quality of the output of laser beams is optimized.

  13. Research of PIM to PSM Transformation Mechanism in Cloud Computing Environment%云计算环境下PIM与PSM的转化机制的研究

    Institute of Scientific and Technical Information of China (English)

    解绍词; 葛君伟

    2011-01-01

    On MDA--based cloud computing platform of software development, aiming at the problems of PIM to PSM reliability transformation, discuss and research the software development modeling process on MDA-based cloud computing environment, PIM and PSM model storage and interface form, and the PIM to PSM reliability transformation mechanism, the model of modeling software development on MDA-based cloud computing environment were presented, and the key technology search for the next step to study are mentioned.%针对基于MDA的云计算软件开发平台下,PIM到PSM之间可靠性转化问题,讨论和研究了基于MI)A的云环境软件开发建模过程、PIM与PSM模型存储与接口形式和MDA的PIM可靠准确转换成PSM的转换机制,给出了基于MDA的云环境软件开发建模模型,并对下一步需要研究的关键技术进行了展望.

  14. Finite-Time Spacecraft’s Soft Landing on Asteroids Using PD and Nonsingular Terminal Sliding Mode Control

    Directory of Open Access Journals (Sweden)

    Keping Liu

    2015-01-01

    Full Text Available This paper presents a continuous control law of probe, which consists of PD (proportional-derivative controller and nonsingular terminal sliding mode controller for probe descending and landing phases, respectively, in the case of the asteroid irregular shape and low gravity. The probe dynamic model is deduced in the landing site coordinate system firstly. Then the reference trajectory based on optimal polynomial in open-loop state is designed, with the suboptimal fuel consumption. Taking into account different characteristics of phases, PD controller and nonsingular terminal sliding mode controller can be employed in the descending phase and the landing phase, respectively, to track the designed reference trajectory. The controller which used the corresponding control methods can meet the motion characteristics and requirements of each stage. Finally simulation experiments are carried out to demonstrate the effectiveness of the proposed method, which can ensure the safe landing of probe and achieve continuous control.

  15. H∞ Filtering for Discrete Markov Jump Singular Systems with Mode-Dependent Time Delay Based on T-S Fuzzy Model

    Directory of Open Access Journals (Sweden)

    Cheng Gong

    2014-01-01

    Full Text Available This paper investigates the H∞ filtering problem of discrete singular Markov jump systems (SMJSs with mode-dependent time delay based on T-S fuzzy model. First, by Lyapunov-Krasovskii functional approach, a delay-dependent sufficient condition on H∞-disturbance attenuation is presented, in which both stability and prescribed H∞ performance are required to be achieved for the filtering-error systems. Then, based on the condition, the delay-dependent H∞ filter design scheme for SMJSs with mode-dependent time delay based on T-S fuzzy model is developed in term of linear matrix inequality (LMI. Finally, an example is given to illustrate the effectiveness of the result.

  16. Gigahertz repetition rate, sub-femtosecond timing jitter optical pulse train directly generated from a mode-locked Yb:KYW laser

    CERN Document Server

    Yang, Heewon; Shin, Junho; Kim, Chur; Choi, Sun Young; Kim, Guang-Hoon; Rotermund, Fabian; Kim, Jungwon

    2014-01-01

    We show that a 1.13-GHz repetition rate optical pulse train with 0.70 fs high-frequency timing jitter (integration bandwidth of 17.5 kHz - 10 MHz, where the measurement instrument-limited noise floor contributes 0.41 fs in 10 MHz bandwidth) can be directly generated from a free-running, single-mode diode-pumped Yb:KYW laser mode-locked by single-walled carbon nanotube (SWCNT)-coated mirrors. To our knowledge, this is the lowest timing jitter optical pulse train with the GHz repetition rate ever measured. If this pulse train is used for direct sampling of 565-MHz signals (Nyquist frequency of the pulse train), the demonstrated jitter level corresponds to the projected effective-number-of-bit (ENOB) of 17.8, which is much higher than the thermal noise limit of 50-ohm load resistance (~14 bits).

  17. Analysis of ASAR Wide Swath Mode time series for the retrieval of soil moisture in mountainous areas

    Science.gov (United States)

    Greifeneder, Felix; Notarnicola, Claudia; Cuozzo, Giovanni; Spindler, Nadine; Bertoldi, Giacomo; Della Chiesa, Stefano; Niedrist, Georg; Stamenkovic, Jelena; Wagner, Wolgang

    2014-05-01

    Soil moisture is a key element in the global cycles of water, energy, and carbon. Knowledge on the spatial and temporal distribution of the soil moisture content (SMC) is therefore essential for a number of hydrological applications as well as earth sciences like meteorology or climatology (Heathman et al., 2003). In the last few years there has been an increasing interest towards the estimation of SMC at local scales using active microwave sensors (Barret et al., 2009). Compared to passive microwave sensors, SAR offers the potential to provide data at high spatial resolution (modern sensors can acquire images with up to approximately 1 m), which is particularly important in mountainous areas. So far, these areas have been considered only marginally in research and only pioneer studies can be found in the literature (Brocca et al., 2012; Bertoldi et al. 2013). In this work we analyzed the temporal and spatial dynamics of the surface SMC (0 - 5 cm depth) on the basis of ground data collected by fixed meteorological stations located in the emerging Long-Term Ecological Research (LTER) site Mazia Valley (Province of Bolzano, South Tyrol, Italy), SAR data from ENVISATs ASAR sensor, wide swath (WS) mode (acquired between 2005 and 2012), and SMC estimates from the hydrological model GEOtop (Endrizzi et al., 2013). The SMC retrieval process was based on the support vector regression (SVR) method introduced by Pasolli et al. (2011). The training of the algorithm was based on data acquired in 2010. Furthermore, the SAR backscatter and derived SMC have been compared with time-series derived from the distributed hydrological model GEOtop. The differences in terms of temporal and spatial dynamic have been analyzed. The main goal of this work is to evaluate the spatial and temporal patterns of SAR derived SMC at field scale and to correlate them with ground information. This is a preparatory study to establish a methodology for the retrieval of SMC with high spatial and

  18. Characterization of the aodA, dnmA, mnSOD and pimA genes in Aspergillus nidulans.

    Science.gov (United States)

    Leiter, Éva; Park, Hee-Soo; Kwon, Nak-Jung; Han, Kap-Hoon; Emri, Tamás; Oláh, Viktor; Mészáros, Ilona; Dienes, Beatrix; Vincze, János; Csernoch, László; Yu, Jae-Hyuk; Pócsi, István

    2016-02-05

    Mitochondria play key roles in cellular energy generation and lifespan of most eukaryotes. To understand the functions of four nuclear-encoded genes predicted to be related to the maintenance of mitochondrial morphology and function in Aspergillus nidulans, systematic characterization was carried out. The deletion and overexpression mutants of aodA, dnmA, mnSOD and pimA encoding alternative oxidase, dynamin related protein, manganese superoxide dismutase and Lon protease, respectively, were generated and examined for their growth, stress tolerances, respiration, autolysis, cell death, sterigmatocystin production, hyphal morphology and size, and mitochondrial superoxide production as well as development. Overall, genetic manipulation of these genes had less effect on cellular physiology and ageing in A. nidulans than that of their homologs in another fungus Podospora anserina with a well-characterized senescence. The observed interspecial phenotypic differences can be explained by the dissimilar intrinsic stabilities of the mitochondrial genomes in A. nidulans and P. anserina. Furthermore, the marginally altered phenotypes observed in A. nidulans mutants indicate the presence of effective compensatory mechanisms for the complex networks of mitochondrial defense and quality control. Importantly, these findings can be useful for developing novel platforms for heterologous protein production, or on new biocontrol and bioremediation technologies based on Aspergillus species.

  19. In Silico Determination of Gas Permeabilities by Non-Equilibrium Molecular Dynamics: CO2 and He through PIM-1

    Directory of Open Access Journals (Sweden)

    Hendrik Frentrup

    2015-03-01

    Full Text Available We study the permeation dynamics of helium and carbon dioxide through an atomistically detailed model of a polymer of intrinsic microporosity, PIM-1, via non-equilibrium molecular dynamics (NEMD simulations. This work presents the first explicit molecular modeling of gas permeation through a high free-volume polymer sample, and it demonstrates how permeability and solubility can be obtained coherently from a single simulation. Solubilities in particular can be obtained to a very high degree of confidence and within experimental inaccuracies. Furthermore, the simulations make it possible to obtain very specific information on the diffusion dynamics of penetrant molecules and yield detailed maps of gas occupancy, which are akin to a digital tomographic scan of the polymer network. In addition to determining permeability and solubility directly from NEMD simulations, the results shed light on the permeation mechanism of the penetrant gases, suggesting that the relative openness of the microporous topology promotes the anomalous diffusion of penetrant gases, which entails a deviation from the pore hopping mechanism usually observed in gas diffusion in polymers.

  20. Softening of infrared-active mode of perovskite BaZrO{sub 3} proved by terahertz time-domain spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Helal, M. A.; Mori, T.; Kojima, S. [Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573 (Japan)

    2015-05-04

    The low-frequency infrared-active optical modes were studied in a barium zirconate, BaZrO{sub 3}, single crystal with the perovskite structure using terahertz (THz) time-domain spectroscopy (TDS). The real and imaginary parts of the dielectric constants were accurately determined in the frequency range between 0.2 and 2.7 THz. Upon cooling from room temperature to 8 K, the lowest-frequency TO1 mode at 2.32 THz showed a pronounced softening to 1.94 THz. The real part of the dielectric constant at 0.5 THz determined by THz-TDS obeys Barrett's relation, and the existence of a plateau confirms that the quantum effects lead to saturation of the soft mode frequencies of the TO1 and TO2 modes below ≈20 K. This is reminiscent of incipient ferroelectrics with the perovskite structure such as CaTiO{sub 3}.

  1. Real-time bilinear rotation decoupling in absorptive mode J-spectroscopy: Detecting low-intensity metabolite peak close to high-intensity metabolite peak with convenience

    Science.gov (United States)

    Verma, Ajay; Baishya, Bikash

    2016-05-01

    "Pure shift" NMR spectra display singlet peak per chemical site. Thus, high resolution is offered at the cost of valuable J-coupling information. In the present work, real-time BIRD (BIlinear Rotation Decoupling) is applied to the absorptive-mode 2D J-spectroscopy to provide pure shift spectrum in the direct dimension and J-coupling information in the indirect dimension. Quite often in metabolomics, proton NMR spectra from complex bio-fluids display tremendous signal overlap. Although conventional J-spectroscopy in principle overcomes this problem by separating the multiplet information from chemical shift information, however, only magnitude mode of the experiment is practical, sacrificing much of the potential high resolution that could be achieved. Few J-spectroscopy methods have been reported so far that produce high-resolution pure shift spectrum along with J-coupling information for crowded spectral regions. In the present work, high-quality J-resolved spectrum from important metabolomic mixture such as tissue extract from rat cortex is demonstrated. Many low-intensity metabolite peaks which are obscured by the broad dispersive tails from high-intensity metabolite peaks in regular magnitude mode J-spectrum can be clearly identified in real-time BIRD J-resolved spectrum. The general practice of removing such spectral overlap is tedious and time-consuming as it involves repeated sample preparation to change the pH of the tissue extract sample and subsequent spectra recording.

  2. Real-time bilinear rotation decoupling in absorptive mode J-spectroscopy: Detecting low-intensity metabolite peak close to high-intensity metabolite peak with convenience.

    Science.gov (United States)

    Verma, Ajay; Baishya, Bikash

    2016-05-01

    "Pure shift" NMR spectra display singlet peak per chemical site. Thus, high resolution is offered at the cost of valuable J-coupling information. In the present work, real-time BIRD (BIlinear Rotation Decoupling) is applied to the absorptive-mode 2D J-spectroscopy to provide pure shift spectrum in the direct dimension and J-coupling information in the indirect dimension. Quite often in metabolomics, proton NMR spectra from complex bio-fluids display tremendous signal overlap. Although conventional J-spectroscopy in principle overcomes this problem by separating the multiplet information from chemical shift information, however, only magnitude mode of the experiment is practical, sacrificing much of the potential high resolution that could be achieved. Few J-spectroscopy methods have been reported so far that produce high-resolution pure shift spectrum along with J-coupling information for crowded spectral regions. In the present work, high-quality J-resolved spectrum from important metabolomic mixture such as tissue extract from rat cortex is demonstrated. Many low-intensity metabolite peaks which are obscured by the broad dispersive tails from high-intensity metabolite peaks in regular magnitude mode J-spectrum can be clearly identified in real-time BIRD J-resolved spectrum. The general practice of removing such spectral overlap is tedious and time-consuming as it involves repeated sample preparation to change the pH of the tissue extract sample and subsequent spectra recording.

  3. Low-timing-jitter, stretched-pulse passively mode-locked fiber laser with tunable repetition rate and high operation stability

    Science.gov (United States)

    Liu, Yuanshan; Zhang, Jian-Guo; Chen, Guofu; Zhao, Wei; Bai, Jing

    2010-09-01

    We design a low-timing-jitter, repetition-rate-tunable, stretched-pulse passively mode-locked fiber laser by using a nonlinear amplifying loop mirror (NALM), a semiconductor saturable absorber mirror (SESAM), and a tunable optical delay line in the laser configuration. Low-timing-jitter optical pulses are stably produced when a SESAM and a 0.16 m dispersion compensation fiber are employed in the laser cavity. By inserting a tunable optical delay line between NALM and SESAM, the variable repetition-rate operation of a self-starting, passively mode-locked fiber laser is successfully demonstrated over a range from 49.65 to 50.47 MHz. The experimental results show that the newly designed fiber laser can maintain the mode locking at the pumping power of 160 mW to stably generate periodic optical pulses with width less than 170 fs and timing jitter lower than 75 fs in the 1.55 µm wavelength region, when the fundamental repetition rate of the laser is continuously tuned between 49.65 and 50.47 MHz. Moreover, this fiber laser has a feature of turn-key operation with high repeatability of its fundamental repetition rate in practice.

  4. Effect of Immersion Time and Cooling Mode on the Electrochemical Behavior of Hot-Dip Galvanized Steel in Sulfuric Acid Medium

    Science.gov (United States)

    Lekbir, Choukri; Dahoun, Nessrine; Guetitech, Asma; Hacid, Abdenour; Ziouche, Aicha; Ouaad, Kamel; Djadoun, Amar

    2017-04-01

    In this work, we investigated the influence of galvanizing immersion time and cooling modes environments on the electrochemical corrosion behavior of hot-dip galvanized steel, in 1 M sulfuric acid electrolyte at room temperature using potentiodynamic polarization technique. In addition, the evolution of thickness, structure and microstructure of zinc coatings for different immersion times and two cooling modes (air and water) is characterized, respectively, by using of Elcometer scan probe, x-ray diffraction and metallography analysis. The analysis of the behavior of steel and galvanized steel, vis-a-vis corrosion, by means of corrosion characteristic parameters as anodic (β a) and cathodic (β c) Tafel slopes, corrosion potential (E corr), corrosion current density (i corr), corrosion rate (CR) and polarization resistance (R p), reveals that the galvanized steel has anticorrosion properties much better than that of steel. More the immersion time increases, more the zinc coatings thickness increases, and more these properties become better. The comparison between the two cooling modes shows that the coatings of zinc produced by hot-dip galvanization and air-cooled provides a much better protection to steel against corrosion than those cooled by quenching in water which exhibit a brittle corrosive behavior due to the presence of cracks.

  5. Cardiac Time Intervals by Tissue Doppler Imaging M-Mode: Normal Values and Association with Established Echocardiographic and Invasive Measures of Systolic and Diastolic Function.

    Directory of Open Access Journals (Sweden)

    Tor Biering-Sørensen

    Full Text Available To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI M-mode through the mitral valve (MV. Furthermore, to evaluate the association of the myocardial performance index (MPI obtained by TDI M-mode (MPITDI and the conventional method of obtaining MPI (MPIConv, with established echocardiographic and invasive measures of systolic and diastolic function.In a large community based population study (n = 974, where all are free of any cardiovascular disease and cardiovascular risk factors, cardiac time intervals, including isovolumic relaxation time (IVRT, isovolumic contraction time (IVCT, and ejection time (ET were obtained by TDI M-mode through the MV. IVCT/ET, IVRT/ET and the MPI ((IVRT+IVCT/ET were calculated. We also included a validation population (n = 44 of patients who underwent left heart catheterization and had the MPITDI and MPIConv measured.IVRT, IVRT/ET and MPI all increased significantly with increasing age in both genders (p<0.001 for all. IVCT, ET, IVRT/ET, and MPI differed significantly between males and females, displaying that women, in general exhibit better cardiac function. MPITDI was significantly associated with invasive (dP/dt max and echocardiographic measures of systolic (LVEF, global longitudinal strain and global strainrate s and diastolic function (e', global strainrate e(p<0.05 for all, whereas MPIConv was significantly associated with LVEF, e' and global strainrate e (p<0.05 for all.Normal values of cardiac time intervals differed between genders and deteriorated with increasing age. The MPITDI (but not MPIConv is associated with most invasive and established echocardiographic measures of systolic and diastolic function.

  6. Second-Order Super-Twisting Sliding Mode Control for Finite-Time Leader-Follower Consensus with Uncertain Nonlinear Multiagent Systems

    Directory of Open Access Journals (Sweden)

    Nan Liu

    2015-01-01

    Full Text Available Consensus tracking problem of the leader-follower multiagent systems is resolved via second-order super-twisting sliding mode control approach. The followers’ states can keep consistent with the leader’s states on sliding surfaces. The proposed approach can ensure the finite-time consensus if the directed graph of the nonlinear system has a directed path under the condition that leader’s control input is unavailable to any followers. It is proved by using the finite-time Lyapunov stability theory. Simulation results verify availability of the proposed approach.

  7. Real time implementation of adaptive sliding mode observer based speed sensor less vector control of induction motor

    Directory of Open Access Journals (Sweden)

    Negadi Karim

    2010-01-01

    Full Text Available Sensor less induction motor drives are widely used in industry for their reliability and flexibility. However, rotor flux and speed sensors are required for vector control of induction motor. These sensors are sources of trouble, mainly in hostile environments, and their application reduces the drive robustness. The cost of the sensors is not also negligible. All the reasons lead to development of different sensor less methods for rotor flux and mechanical speed estimation in electrical drives. The paper deals with the speed estimators for applications in sensor less induction motor drive with vector control, which are based on application of model adaptive, based sliding mode observer methods. This paper presents the development and DSP implementation of the speed estimators for applications in sensor less drives with induction motor.

  8. Reduction of timing jitter and intensity noise in normal-dispersion passively mode-locked fiber lasers by narrow band-pass filtering.

    Science.gov (United States)

    Qin, Peng; Song, Youjian; Kim, Hyoji; Shin, Junho; Kwon, Dohyeon; Hu, Minglie; Wang, Chingyue; Kim, Jungwon

    2014-11-17

    Fiber lasers mode-locked with normal cavity dispersion have recently attracted great attention due to large output pulse energy and femtosecond pulse duration. Here we accurately characterized the timing jitter of normal-dispersion fiber lasers using a balanced cross-correlation method. The timing jitter characterization experiments show that the timing jitter of normal-dispersion mode-locked fiber lasers can be significantly reduced by using narrow band-pass filtering (e.g., 7-nm bandwidth filtering in this work). We further identify that the timing jitter of the fiber laser is confined in a limited range, which is almost independent of cavity dispersion map due to the amplifier-similariton formation by insertion of the narrow bandpass filter. The lowest observed timing jitter reaches 0.57 fs (rms) integrated from 10 kHz to 10 MHz Fourier frequency. The rms relative intensity noise (RIN) is also reduced from 0.37% to 0.02% (integrated from 1 kHz to 5 MHz Fourier frequency) by the insertion of narrow band-pass filter.

  9. A Nonsingular Terminal Sliding Mode Approach Using Adaptive Disturbance Observer for Finite-Time Trajectory Tracking of MEMS Triaxial Vibratory Gyroscope

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2015-01-01

    Full Text Available This paper develops a nonsingular terminal sliding mode controller (NTSMC with adaptive disturbance observer (ADOB for finite-time trajectory tracking of a MEMS triaxial vibratory gyroscope, which has parameter variations and external high-amplitude disturbance. A novel sliding mode controller with adaptive disturbance observer is designed to reconfigure the parameter variations and external high-amplitude disturbance and reduce the chattering phenomenon on the sliding surface greatly through setting the switching gain in control signal as a smaller value. The disturbance adaptive law is derived to guarantee the stability of the closed-loop adaptive control system via the Lyapunov criterion. The simulation results are performed to verify the effectiveness of the presented schemes.

  10. A survey on time and frequency characteristics of induction motors with broken rotor bars in line-start and inverter-fed modes

    Science.gov (United States)

    Ghorbanian, Vahid; Faiz, Jawad

    2015-03-01

    This paper deals with the comprehensive detailed concepts of the rotor broken bars fault in industrial induction motors. It reviews the most important and applicable techniques for fault detection, and addresses fault diagnosing procedures at different supply modes including line-start and inverter-fed modes. Moreover, new analytical and experimental aspects of fault are proposed using the time and frequency domain variations of the motor variables such as current, voltage, electromagnetic torque and speed. Since the faulty motor behavior cannot be correctly identified without considering the motor operating condition, and the capability of the previous fault indicators are studied deeply in order to investigate their applicability at different conditions. These conditions include various faults, load and reference speed levels and also fault location. All in all, a precise condition assessment of the rotor broken bar induction motors, suitable for industrial purposes, is presented considering motor supply and conditions changes.

  11. Robust stability analysis for Markovian jumping stochastic neural networks with mode-dependent time-varying interval delay and multiplicative noise

    Institute of Scientific and Technical Information of China (English)

    Zhang Hua-Guang; Fu Jie; Ma Tie-Dong; Tong Shao-Cheng

    2009-01-01

    This paper is concerned with the problem of robust stability for a class of Markovian jumping stochastic neural networks (MJSNNs) subject to mode-dependent time-varying interval delay and state-multiplicative noise.Based on the Lyapunov-Krasovskii functional and a stochastic analysis approach,some new delay-dependent sufficient conditions are obtained in the linear matrix inequality (LMI) format such that delayed MJSNNs are globally asymptotically stable in the mean-square sense for all admissible uncertainties.An important feature of the results is that the stability criteria are dependent on not only the lower bound and upper bound of delay for all modes but also the covariance matrix consisting of the correlation coefficient.Numerical examples are given to illustrate the effectiveness.

  12. Roles of default-mode network and supplementary motor area in human vigilance performance: evidence from real-time fMRI.

    Science.gov (United States)

    Hinds, Oliver; Thompson, Todd W; Ghosh, Satrajit; Yoo, Julie J; Whitfield-Gabrieli, Susan; Triantafyllou, Christina; Gabrieli, John D E

    2013-03-01

    We used real-time functional magnetic resonance imaging (fMRI) to determine which regions of the human brain have a role in vigilance as measured by reaction time (RT) to variably timed stimuli. We first identified brain regions where activation before stimulus presentation predicted RT. Slower RT was preceded by greater activation in the default-mode network, including lateral parietal, precuneus, and medial prefrontal cortices; faster RT was preceded by greater activation in the supplementary motor area (SMA). We examined the roles of these brain regions in vigilance by triggering trials based on brain states defined by blood oxygenation level-dependent activation measured using real-time fMRI. When activation of relevant neural systems indicated either a good brain state (increased activation of SMA) or a bad brain state (increased activation of lateral parietal cortex and precuneus) for performance, a target was presented and RT was measured. RTs on trials triggered by a good brain state were significantly faster than RTs on trials triggered by a bad brain state. Thus human performance was controlled by monitoring brain states that indicated high or low vigilance. These findings identify neural systems that have a role in vigilance and provide direct evidence that the default-mode network has a role in human performance. The ability to control and enhance human behavior based on brain state may have broad implications.

  13. The influence of impact delivery mode, lactation time, infant gender, maternal age and rural or urban life on total number of Lactobacillus in breast milk Isfahan - Iran.

    Science.gov (United States)

    Taghizadeh, Mansoureh; Mirlohi, Maryam; Poursina, Farkhondeh; Madani, Golnoush; Khoshhali, Mehri; Bahreini, Nimah; Safaei, Hajieh Ghasemian

    2015-01-01

    Breast milk is known as the most crucial postpartum issue in metabolic and immunologic programming of neonatal health. Human milk microbial changes over Lactation. The factors influencing the milk microbiome as well as potential impact of microbes on infant health have not yet been discovered. The objective was to identify pre- and post-natal factors that can potentially influence the bacterial communities inhabiting human milk. Breast milk samples (n = 40) with all full-term breastfed infants were collected from lactating randomized. Information on personal characteristics, dietary habits, information about infants were collected after birth. The samples were plated with serial dilutions on three selective culture media man rogosa sharp and then colonies were counted. Colonies tested for catalase reaction, Gram-staining and microscopic examination. The result of this study showed that the overall incidence of positive Lactobacillus in mother's milk was 87.5%. The results based on (infant gender, mode of delivery, rural or urban and lactation time) rural or urban and lactation time were significant (P < 0.05). The results showed that all of the variables were significant in this regression model (P < 0.001). The median of log10 Lactobacillus counts in rural mothers, vaginal delivery, infant male gender and Lactation time for first 3-month were meaningfully high. The findings of this study about the breast milk Lactobacillus potential probiotic bacteria of healthy Iranian mothers, suggested that the breast milk microbiome is significantly influenced by several factors, mode of delivery, rural or urban and lactation time.

  14. Synchronizing atomic force microscopy force mode and fluorescence microscopy in real time for immune cell stimulation and activation studies

    Energy Technology Data Exchange (ETDEWEB)

    Cazaux, Séverine; Sadoun, Anaïs; Biarnes-Pelicot, Martine; Martinez, Manuel; Obeid, Sameh [Aix Marseille Université, LAI UM 61, Marseille F-13288 (France); Inserm, UMR-S 1067, Marseille F-13288 (France); CNRS, UMR 7333, Marseille F-13288 (France); Bongrand, Pierre [Aix Marseille Université, LAI UM 61, Marseille F-13288 (France); Inserm, UMR-S 1067, Marseille F-13288 (France); CNRS, UMR 7333, Marseille F-13288 (France); APHM, Hôpital de la Conception, Laboratoire d’Immunologie, Marseille F-13385 (France); Limozin, Laurent [Aix Marseille Université, LAI UM 61, Marseille F-13288 (France); Inserm, UMR-S 1067, Marseille F-13288 (France); CNRS, UMR 7333, Marseille F-13288 (France); Puech, Pierre-Henri, E-mail: pierre-henri.puech@inserm.fr [Aix Marseille Université, LAI UM 61, Marseille F-13288 (France); Inserm, UMR-S 1067, Marseille F-13288 (France); CNRS, UMR 7333, Marseille F-13288 (France)

    2016-01-15

    A method is presented for combining atomic force microscopy (AFM) force mode and fluorescence microscopy in order to (a) mechanically stimulate immune cells while recording the subsequent activation under the form of calcium pulses, and (b) observe the mechanical response of a cell upon photoactivation of a small G protein, namely Rac. Using commercial set-ups and a robust signal coupling the fluorescence excitation light and the cantilever bending, the applied force and activation signals were very easily synchronized. This approach allows to control the entire mechanical history of a single cell up to its activation and response down to a few hundreds of milliseconds, and can be extended with very minimal adaptations to other cellular systems where mechanotransduction is studied, using either purely mechanical stimuli or via a surface bound specific ligand. - Highlights: • A signal coupling AFM and fluorescence microscopy was characterized for soft cantilevers. • It can be used as an intrinsic timer to synchronize images and forces. • Mechanical stimulation of single immune cells while recording calcium fluxes was detailed. • Light-induced mechanical modifications of lymphocytes using a PA-Rac protein were demonstrated. • The precautions and limitations of use of this effect were presented.

  15. Evaluation of Energy Saving Operational Modes for Industrial Fracture Connected Processes on the Basis of Incubation Time Fracture Criterion

    Institute of Scientific and Technical Information of China (English)

    Bratov Vladimir; Petrov Yuri

    2008-01-01

    A problem for a central crack in a plate subjected to plane strain conditions is investigated.Mode Ⅰ crack loading is created by a dynamic pressure pulse applied at a large distance from the crack.It was found that for a certain combination of amplitude and duration of the pulse applied,the energy transmitted to the sample has a strongly marked minimum,meaning that with the pulse amplitude or duration moving away from the optimal values,minimum energy required for initiation of crack growth increases rapidly.The results obtained indicate a possibility to optimise energy consumption of different industrial processes connected with fracture.Much could be gained in,for example,drilling or rock pounding where energy input accounts for the largest part of the process cost.Presumably further investigation of the effect observed can make it possible to predict optimal energy saving parameters,i.e.frequency and amplitude of impacts,for industrial devices,e.g.bores,grinding machines,and hence significantly reduce the process cost.The prediction can be given based on the parameters of the media fractured (material parameters,prevalent crack length and orientation,etc.).

  16. The Application of PIMS to Optimization of Production Plan in Tahe Branch Company%PIMS在塔河炼化生产计划优化中的应用

    Institute of Scientific and Technical Information of China (English)

    毛爱华

    2014-01-01

    介绍了中国石油化工股份有限公司塔河炼化有限责任公司利用PIMS软件优化炼油生产计划的情况。PIMS软件是炼油企业取得经济效益最大化的重要优化工具,PIMS软件的测算结果为优化生产计划提供了有力依据。%The application of PIMS software to optimization of refinery production plan was introduced in Tahe Branch Co., LTD., Sinopec. PIMS software is an important optimization tool in order to refinery to obtain economic benefit maximization, measuring re-sults of PIMS software to optimize the production plan provides the strong basis.

  17. Research and development of a gaseous detector PIM (parallel ionization multiplier) dedicated to particle tracking under high hadron rates; Recherche et developpement d'un detecteur gazeux PIM (Parallel Ionization Multiplier) pour la trajectographie de particules sous un haut flux de hadrons

    Energy Technology Data Exchange (ETDEWEB)

    Beucher, J

    2007-10-15

    PIM (Parallel Ionization Multiplier) is a multi-stage micro-pattern gaseous detector using micro-meshes technology. This new device, based on Micromegas (micro-mesh gaseous structure) detector principle of operation, offers good characteristics for minimum ionizing particles track detection. However, this kind of detectors placed in hadron environment suffers discharges which degrade sensibly the detection efficiency and account for hazard to the front-end electronics. In order to minimize these strong events, it is convenient to perform charges multiplication by several successive steps. Within the framework of a European hadron physics project we have investigated the multi-stage PIM detector for high hadrons flux application. For this part of research and development, a systematic study for many geometrical configurations of a two amplification stages separated with a transfer space operated with the gaseous mixture Ne + 10% CO{sub 2} has been performed. Beam tests realised with high energy hadrons at CERN facility have given that discharges probability could be strongly reduced with a suitable PIM device. A discharges rate lower to 10{sup 9} by incident hadron and a spatial resolution of 51 {mu}m have been measured at the beginning efficiency plateau (>96 %) operating point. (author)

  18. R&D Requirements, RF Gun Mode Studies, FEL-2 Steady-StateStudies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary LayoutOption Investigation

    Energy Technology Data Exchange (ETDEWEB)

    Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

    2005-10-01

    This report constitutes the third deliverable of LBNLs contracted role in the FERMI {at} Elettra Technical Optimization study. It describes proposed R&D activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac.

  19. Fast scintillation timing detector using proportional-mode avalanche photodiode for nuclear resonant scattering experiments in high-energy synchrotron X-ray region

    Science.gov (United States)

    Inoue, Keisuke; Kishimoto, Shunji

    2016-01-01

    To obtain both a high count rate of >107 s-1 and a detection efficiency sufficient for high-energy X-rays of >30 keV, we propose a scintillation timing detector using a proportional-mode silicon avalanche photodiode (Si-APD) for synchrotron radiation nuclear resonant scattering. We here present results obtained with a prototype detector using a lead-loaded plastic scintillator (EJ-256) mounted on a proportional-mode Si-APD (active area size: 3 mm in diameter). The detector was operated at ‒35 °C for a better signal-to-noise ratio. Using synchrotron X-rays of 67.41 keV, which is the same energy as the first excited level of 61Ni, we successfully measured pulse-height and time spectra of the scintillation light. A good time resolution of 0.50±0.06 ns (full width at half-maximum) was obtained for 67.41 keV X-rays with a scintillator 3 mm in diameter and 2 mm thick.

  20. Diversity of Decline-Rate-Corrected Type 1a Supernova Rise times:One Mode or Two?

    Energy Technology Data Exchange (ETDEWEB)

    Strovink, Mark

    2007-05-01

    B-band light-curve rise times for eight unusually well-observed nearby Type Ia supernova (SNe) are fitted by a newly developed template-building algorithm, using light-curve functions that are smooth, flexible, and free of potential bias from externally derived templates and other prior assumptions. From the available literature, photometric BVRI data collected over many months, including the earliest points, are reconciled, combined, and fitted to a unique time of explosion for each SN. On average, after they are corrected for light-curve decline rate, three SNe rise in 18.81 {+-} 0.36 days, while five SNe rise in 16.64 {+-} 0.21 days. If all eight SNe are sampled from a single parent population (a hypothesis not favored by statistical tests), the rms intrinsic scatter of the decline-rate-corrected SN rise time is 0.96{sub -0.25}{sup +0.52} days--a first measurement of this dispersion. The corresponding global mean rise time is 17.44 {+-} 0.39 days, where the uncertainty is dominated by intrinsic variance. This value is {approx}2 days shorter than two published averages that nominally are twice as precise, though also based on small samples. When comparing high-z to low-z SN luminosities for determining cosmological parameters, bias can be introduced by use of a light-curve template with an unrealistic rise time. If the period over which light curves are sampled depends on z in a manner typical of current search and measurement strategies, a two-day discrepancy in template rise time can bias the luminosity comparison by {approx}0.03 magnitudes.

  1. Effect of porcine reproductive and respiratory syndrome virus (PRRSV) (isolate ATCC VR-2385) infection on bactericidal activity of porcine pulmonary intravascular macrophages (PIMs): in vitro comparisons with pulmonary alveolar macrophages (PAMs).

    Science.gov (United States)

    Thanawongnuwech, R; Thacker, E L; Halbur, P G

    1997-11-01

    Porcine pulmonary intravascular macrophages (PIMs) were recovered by in situ pulmonary vascular perfusion with 0.025% collagenase in saline from six 8-week old, crossbred pigs. Pulmonary alveolar macrophages (PAMs) were recovered by bronchoalveolar lavage from the same pigs for comparisons in each assay. The macrophages were exposed to PRRSV (ATCC VR-2385) in vitro for 24 h and infection was confirmed by an indirect immunofluorescence test or transmission electron microscopy. Viral particles tended to accumulate in the vesicles of the Golgi apparatus or endoplasmic reticulum. Bactericidal function assays were performed on the recovered macrophages to determine the effects of the virus on macrophage functions. In vitro PRRSV infection reduced the bactericidal ability of PIMs from 68.3% to 56.4% (P PAMs from 69.3% to 61.0% (P > 0.1) at 24 h post-infection. The mean percentage of bacteria killed by macrophages after PRRSV infection was not significantly different among the treatment groups or between the treatment groups and non-infected controls based on colorimetric MTT bactericidal (Staphylococcus aureus) assay. PRRSV did not affect the ability of PIMs or PAMs to internalize opsonized 125I-iododeoxyuridine-labeled S. aureus (P > 0.05). PRRSV infection significantly decreased the production of superoxide anion (P PAMs. PRRSV reduced the myeloperoxidase-H2O2-halide product (P PAMs. The results suggest: (1) PIMs should be considered as an important replication site of PRRSV; (2) PRRSV may have a detrimental effect on both PIMs and PAMs; (3) loss of bactericidal function in PIMs may facilitate hematogenous bacterial infections.

  2. Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted).

    Science.gov (United States)

    Ark, B; Gummere, G; Bennett, D; Artzt, K

    1991-06-01

    Pim-1 is an oncogene activated in mouse T-cell lymphomas induced by Moloney and AKR mink cell focus (MCF) viruses. Pim-1 was previously mapped to chromosome 17 by somatic cell hybrids, and subsequently to the region between the hemoglobin alpha-chain pseudogene 4 (Hba-4ps) and the alpha-crystalline gene (Crya-1) by Southern blot analysis of DNA obtained from panels of recombinant inbred strains. We have now mapped Pim-1 more accurately in t-haplotypes by analysis of recombinant t-chromosomes. The recombinants were derived from Tts6tf/t12 parents backcrossed to + tf/ + tf, and scored for recombination between the loci of T and tf. For simplicity all t-complex lethal genes properly named tcl-tx are shortened to tx. The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes. Once mapped, the Pim-1 gene was used as a marker for further genetic analysis of t-haplotypes. tw12 is so close to tf that even with a large number of recombinants it was not possible to determine whether it is proximal or distal to tf. Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf. The mapping of two allelic t-lethals, t0 and t6 with respect to tw12 and tf has also been a problem.(ABSTRACT TRUNCATED AT 250 WORDS)

  3. The Comparison of Mode Choice Sensitivity to the Reduction of Travel Time and Cost in Multimodal Trip

    Directory of Open Access Journals (Sweden)

    Mohammad Ganji

    2013-07-01

    Full Text Available Nowadays, with the extension of travel distances and accessibility to the various commuting options, multimodal trip proposes as the most competent travelling strategy. However, with increasing in demand by using these options as well as metro, subway, buses, cycles and sidewalk, some problems arose. The import of this quantitative study is to sympathize with the significance of the multimodal as a novel factor in the transportation. In this study, we discussed about cost and time as two significant factors, which affect everybody's life. While improving these two factors have a meaningful effect on encouraging/discouraging private vehicle commuters to switch to public transport. The methodology of this study is an empirical research in which a survey was conducted among the students at The National University of Malaysia with a numeric sample. Hence, a case study based on areas around UKM campus is used to demonstrate the results. What were investigated in this study were the attributes of a reduction in either travel cost or time to promote people who use their own vehicles to shift toward public transportation. The results show that the two factors: time and cost made a significant contribution in motivating private vehicle users to switch public transport. However, the most important purpose of this study was determining the most effective factor (at least based on our condition since it's not practically possible to have the travel time and cost reduction together.

  4. Photo-physics study of an hydroxy-quinoline derivative as inhibitor of Pim-1 kinase

    DEFF Research Database (Denmark)

    Lamhasni, T.; Aitlyazidi, S.; Hnach, M.

    2013-01-01

    The photophysical properties of the antiviral 7-nicotinoyl-styrylquinoline (MB96) were investigated by means of UV-Vis linear dichroism (LD) spectroscopy on molecular samples aligned in stretched polyvinylalcohol (PVA), supported by Time Dependent Density Functional Theory (TD-DFT) calculations...

  5. Screening and selective quantification of illicit drugs in wastewater by mixed-mode solid-phase extraction and quadrupole-time-of-flight liquid chromatography-mass spectrometry.

    Science.gov (United States)

    González-Mariño, Iria; Quintana, José Benito; Rodríguez, Isaac; González-Díez, Marta; Cela, Rafael

    2012-02-07

    For the first time, a mixed-mode solid-phase extraction with fractionation of basic analytes from neutral and acidic species during cartridge elution and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) was combined for the quantitative determination of 24 illicit drugs and metabolites in urban sewage samples. The effects of several sample preparation and instrumental parameters in the sensitivity and selectivity of the quantitative method are thoroughly discussed. Under final working conditions, recoveries above 63% and 82% were attained for all species in raw and treated sewage, respectively; whereas, the limits of quantification of the method, defined for a signal-to-noise of 10 (S/N = 10), ranged from 2 to 50 ng L(-1). Sequential elution of mixed-mode cartridges allowed a significant reduction of matrix effects observed during electrospray ionization of basic drugs versus those measured for hydrophilic balance reversed-phase sorbents and the same mixed-mode polymer without fractionated elution. Analysis of raw wastewater samples confirmed the ubiquity of cocaine (COC), benzoylecgonine (BE), and 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THCCOOH) in this matrix. The capability of the above methodology to identify new illicit drugs and/or metabolites in sewage samples is also discussed. With this aim, a two step strategy is proposed. First, high-resolution MS chromatograms, acquired throughout each chromatographic run, are automatically searched against an in-house built database, a reduced list of candidate drugs is generated, and the corresponding extracted ion chromatograms are obtained. In a further LC run, the tandem mass spectrometry (MS/MS) spectra of unknown peaks are acquired using different collision energies and compared with those existing in public libraries, or interpreted, to assign the unknown peak to one of the previously selected candidates.

  6. Global normal mode planetary wave activity: a study using TIMED/SABER observations from the stratosphere to the mesosphere-lower thermosphere

    Science.gov (United States)

    John, Sherine Rachel; Kumar, Karanam Kishore

    2016-12-01

    A comprehensive study of three normal mode travelling planetary waves, namely the quasi-16, -10 and -5 day waves, is carried out globally using 5 years (2003-2007) of TIMED/SABER temperature measurements from the stratosphere to the mesosphere-lower thermosphere (MLT) by employing the two dimensional Fourier decomposition technique. From preliminary analysis, it is found that significant amplitudes of normal modes are confined to wave numbers-2 (westward propagating modes) to 2 (eastward propagating modes). The westward propagating quasi 16-day waves with zonal wave number 1 (W1; W1 refers to westward propagating wave with zonal wave number 1) peaks over winter-hemispheric high latitudes with northern hemisphere (NH) having higher amplitudes as compared to their southern hemispheric (SH) counterpart. The W1 quasi 16-day waves exhibit a double peak structure in altitude over winter hemispheric high latitudes. The eastward propagating quasi 16-day waves with wave number 1 (E1; E1 refers to eastward propagating wave with zonal wave number 1) exhibits similar features as that of W1 waves in the NH. In contrast, the E1 quasi 16-day waves in the SH show larger amplitudes as compared to the W1 waves and they do not exhibit double peak structure in altitude. Similar to the quasi 16-day waves, the quasi 10- and 5-day wave amplitudes with respect to their wavenumbers are delineated. Unlike quasi-16 and -10 day waves, quasi-5 day waves peak during vernal equinox both in the SH and NH. The peak activity of the W1 quasi-5 day wave is centered around 40°N and 40°S exhibiting symmetry with respect to the equator. A detailed discussion on the height-latitude structure, interannual variability and inter-hemispheric propagation of quasi 16-, 10- and 5-day waves are discussed. The significance of the present study lies in establishing the 5-year climatology of normal mode planetary waves from the stratosphere to the MLT region including their spatial-temporal evolution, which are

  7. Real-time operating mode with DSSSD detector to search for short correlation ER-alpha chains

    CERN Document Server

    Tsyganov, Yury

    2015-01-01

    Real-time PC based algorithm is developed for DSSSD detector. Complete fusion nuclear reaction natYb+48Ca->217Th is used to test this algorithm at 48Ca beam. Example of successful application of a former algorithm for resistive strip PIPS detector in 249Bk+48Ca nuclear reaction is presented too. Case of alpha-alpha correlations is also under brief consideration.

  8. Thermal bistability-based method for real-time optimization of ultralow-threshold whispering gallery mode microlasers

    CERN Document Server

    Lin, Guoping; Tillement, O; Cai, Zhiping; Lefèvre-Seguin, V; Hare, J

    2015-01-01

    A method based on thermal bistability for ultralow-threshold microlaser optimization is demonstrated. When sweeping the pump laser frequency across a pump resonance, the dynamic thermal bistability slows down the power variation. The resulting line shape modification enables a real-time monitoring of the laser characteristic. We demonstrate this method for a functionalized microsphere exhibiting a submicrowatt laser threshold. This approach is confirmed by comparing the results with a step-by-step recording in quasi-static thermal conditions.

  9. The Broad Iron K-alpha line of Cygnus X-1 as Seen by XMM-Newton in the EPIC-pn Modified Timing Mode

    Science.gov (United States)

    Duro, Refiz; Dauser, Thomas; Wilms, Jorn; Pottschmidt, Katja; Nowak, Michael A.; Fritz, Sonja; Kendziorra, Eckhard; Kirsch, Marcus G. F.; Reynolds, Christopher S.; Staubert, Rudiger

    2011-01-01

    We present the analysis of the broadened, flourescent iron K(alpha) line in simultaneous XMM-Newton and RXTE data from the black hole Cygnus X-I. The XMM-Newton data were taken in a modified version of the Timing Mode of the EPIC-pn camera. In this mode the lower energy threshold of the instrument is increased to 2.8 keV to avoid telemetry drop outs due to the brightness of the source, while at the same time preserving the signal to noise ratio in the Fe K(alpha) band. We find that the best-fit spectrum consists of the sum of an exponentially cut-off power-law and relativistically smeared, ionized reflection. The shape of the broadened Fe K(alpha) feature is due to strong Compton broadening combined with relativistic broadening. Assuming a standard, thin accretion disk, the black hole is close to maximally rotating. Key words. X-rays: binaries - black hole physics - gravitation

  10. Detection of aqueous phase chemical warfare agent degradation products by negative mode ion mobility time-of-flight mass spectrometry [IM(tof)MS].

    Science.gov (United States)

    Steiner, Wes E; Harden, Charles S; Hong, Feng; Klopsch, Steve J; Hill, Herbert H; McHugh, Vincent M

    2006-02-01

    The use of negative ion monitoring mode with an atmospheric pressure ion mobility orthogonal reflector time-of-flight mass spectrometer [IM(tof)MS] to detect chemical warfare agent (CWA) degradation products from aqueous phase samples has been determined. Aqueous phase sampling used a traditional electrospray ionization (ESI) source for sample introduction and ionization. Certified reference materials (CRM) of CWA degradation products for the detection of Schedule 1, 2, or 3 toxic chemicals or their precursors as defined by the chemical warfare convention (CWC) treaty verification were used in this study. A mixture of six G-series nerve related CWA degradation products (EMPA, IMPA, EHEP, IHEP, CHMPA, and PMPA) and their related collision induced dissociation (CID) fragment ions (MPA and EPA) were found in each case to be clearly resolved and detected using the IM(tof)MS instrument in negative ion monitoring mode. Corresponding ions, masses, drift times, K(o) values, and signal intensities for each of the CWA degradation products are reported.

  11. The detection of quasinormal mode with $a/M \\sim 0.95$ would prove a sphere $99\\%$ soaking in the ergoregion of the Kerr space-time

    CERN Document Server

    Nakano, Hiroyuki; Tanaka, Takahiro

    2016-01-01

    Recent numerical relativity simulations of mergers of binary black holes suggest that the maximum final value of $a/M$ is $\\sim 0.95$ for the coalescence of two equal mass black holes with aligned spins of the same magnitude $a/M=0.994$ which is close to the upper limit $a/M=0.998$ of accretion spin-up shown by Thorne. Using the WKB method, we suggest that if quasinormal modes with $a/M \\sim 0.95$ are detected by the second generation gravitational wave detectors, we could confirm the strong gravity space-time based on Einstein's general relativity up to $1.33M$ which is only $\\sim 1.014$ times the event horizon radius and within the ergoregion. One more message about black hole geometry is expected here. If the quasinormal mode is different from that of general relativity, we need to find the true theory of gravity which deviates from general relativity only near the black hole horizon.

  12. [The validation of kit of reagents for quantitative detection of DNA of human cytomegalovirus in biological material using polymerase chain reaction technique in real time operation mode].

    Science.gov (United States)

    Sil'veĭstrova, O Iu; Domonova, É A; Shipulina, O Iu

    2014-04-01

    The validation of kit of reagents destined to detection and quantitative evaluation of DNA of human cytomegalovirus in biological material using polymerase chain reaction technique in real time operation mode was implemented. The comparison was made against international WHO standard--The first WHO international standard for human cytomegalovirus to implement measures the kit of reagents "AmpliSens CMV-screen/monitor-FL" and standard sample of enterprise DNA HCMV (The central research institute of epidemiology of Rospotrebnadzor) was applied. The fivefold dilution of international WHO standard and standard sample of enterprise were carried out in concentrations of DNA HCMV from 106 to 102. The arrangement of polymerase chain reaction and analysis of results were implemented using programed amplifier with system of detection of fluorescent signal in real-time mode "Rotor-Gene Q" ("Qiagen", Germany). In the total of three series of experiments, all stages of polymerase chain reaction study included, the coefficient of translation of quantitative evaluation of DNA HCMV from copy/ml to ME/ml equal to 0.6 was introduced for this kit of reagents.

  13. Development of fast scattering model of complex shape target for seminatural tests of onboard proximity radars in real time mode

    Directory of Open Access Journals (Sweden)

    Likhoedenko Andrei K.

    2016-01-01

    Full Text Available Problems of creation of models of real time of complex shape targets on the basis of use of their polygonal models are considered. Formulas for radar cross section of multipoint model of target and power of input signal of onboard radar are described. Technique of semi-natural tests of onboard radar detector on the base of multipoint model of target is proposed. Results of digital simulation of input signals of the onboard radar detector of the target from the aerodynamic target on the basis of their multipoint models are given.

  14. A 1.5 ns OFF/ON switching-time voltage-mode LVDS driver/receiver pair for asynchronous AER bit-serial chip grid links with up to 40 times event-rate dependent power savings.

    Science.gov (United States)

    Zamarreno-Ramos, Carlos; Kulkarni, Raghavendra; Silva-Martinez, Jose; Serrano-Gotarredona, Teresa; Linares-Barranco, Bernabe

    2013-10-01

    This paper presents a low power fast ON/OFF switchable voltage mode implementation of a driver/receiver pair intended to be used in high speed bit-serial Low Voltage Differential Signaling (LVDS) Address Event Representation (AER) chip grids, where short (like 32-bit) sparse data packages are transmitted. Voltage-Mode drivers require intrinsically half the power of their Current-Mode counterparts and do not require Common-Mode Voltage Control. However, for fast ON/OFF switching a special high-speed voltage regulator is required which needs to be kept ON during data pauses, and hence its power consumption must be minimized, resulting in tight design constraints. A proof-of-concept chip test prototype has been designed and fabricated in low-cost standard 0.35 μ m CMOS. At ± 500 mV voltage swing with 500 Mbps serial bit rate and 32 bit events, current consumption scales from 15.9 mA (7.7 mA for the driver and 8.2 mA for the receiver) at 10 Mevent/s rate to 406 μ A ( 343 μ A for the driver and 62.5 μA for the receiver) for an event rate below 10 Kevent/s, therefore achieving a rate dependent power saving of up to 40 times, while keeping switching times at 1.5 ns. Maximum achievable event rate was 13.7 Meps at 638 Mbps serial bit rate. Additionally, differential voltage swing is tunable, thus allowing further power reductions.

  15. Phonon Mode Transformation Across the Orthohombic-Tetragonal Phase Transition in a Lead Iodide Perovskite CH3NH3PbI3: A Terahertz Time-Domain Spectroscopy Approach.

    Science.gov (United States)

    La-o-Vorakiat, Chan; Xia, Huanxin; Kadro, Jeannette; Salim, Teddy; Zhao, Daming; Ahmed, Towfiq; Lam, Yeng Ming; Zhu, Jian-Xin; Marcus, Rudolph A; Michel-Beyerle, Maria-Elisabeth; Chia, Elbert E M

    2016-01-07

    We study the temperature-dependent phonon modes of the organometallic lead iodide perovskite CH3NH3PbI3 thin film across the terahertz (0.5-3 THz) and temperature (20-300 K) ranges. These modes are related to the vibration of the Pb-I bonds. We found that two phonon modes in the tetragonal phase at room temperature split into four modes in the low-temperature orthorhombic phase. By use of the Lorentz model fitting, we analyze the critical behavior of this phase transition. The carrier mobility values calculated from the low-temperature phonon mode frequencies, via two theoretical approaches, are found to agree reasonably with the experimental value (∼2000 cm(2) V(-1) s(-1)) from a previous time-resolved THz spectroscopy work. Thus, we have established a possible link between terahertz phonon modes and the transport properties of perovskite-based solar cells.

  16. Correlation between long-term marine temperature time series from the eastern and western English Channel: Scaling analysis using empirical mode decomposition

    Science.gov (United States)

    Derot, Jonathan; Schmitt, François Guillaume; Gentilhomme, Valérie; Morin, Pascal

    2016-05-01

    High-frequency temperature fluctuations recorded in the English Channel are compared using two long-term autonomous underwater monitoring stations at less than 20-min time resolution. Measurements were taken from 2005 to 2011 from two systems 460 km apart in the western and eastern parts of the English Channel. Spectral analysis reveals similar statistical behaviors, with approximate 5/3 spectra and several forcing frequencies in relation to tidal and daily cycles. A co-spectra study reveals a transition scale of 11 days. The influence of this scale is also visible though Time-Dependent Intrinsic Correlation analysis (TDIC)-a recently introduced cross-correlation analysis based on Empirical mode decomposition. This helps to spatialize high-frequency temporal records at a fixed location.

  17. The effects of mode of delivery and time since birth on chronic pelvic pain and health-related quality of life.

    Science.gov (United States)

    Li, Wen-Ying; Liabsuetrakul, Tippawan; Stray-Pedersen, Babill; Li, Ya-Jun; Guo, Li-Jie; Qin, Wen-Zhi

    2014-02-01

    To assess the effects of mode of delivery and time since birth on chronic pelvic pain (CPP) and health-related quality of life (HRQoL) among primiparous Chinese women. Primiparous women of childbearing age who had given birth at least 6months previously were invited to participate in the present cross-sectional study, which was conducted from October 2011 to April 2012 in the Chaoyang District of Beijing. Time since birth was divided into the following 4 periods: less than 1year, 1-5years, 6-10years, and more than 10years. The factors associated with CPP status were analyzed using logistic regression. Among the 1456 participants, CPP was more common following cesarean delivery (11.2% versus 6.9% among women with a vaginal delivery; P=0.007), and the rate of CPP increased with time since birth (2.3%, 9.3%, 10.7%, and 13.1% for the 4 specified time periods, respectively (Pdelivery, longer time since birth, and CPP were all associated with a lower HRQoL utility score. Although the absolute risks were small, cesarean delivery and time since birth were significant risk factors for CPP, which had a negative impact on the participants' HRQoL. © 2013. Published by Elsevier Ireland Ltd on behalf of International Federation of Gynecology and Obstetrics. All rights reserved.

  18. STUDY OF PRIOR PREPAREDNESS AND AWARENESS REGARDING THE MBBS COURSE AMONGST FIRST YEAR STUDENTS ADMITTED AT RURAL MEDICAL COLLEGE, OF PIMS-DU, LONI

    Directory of Open Access Journals (Sweden)

    Padmanabhan P, Kunkulol R, Jangle SN

    2015-04-01

    Full Text Available Background: Adolescents in India choose career in medicine under the influence and pressure from parents, family members, peers and external sources. There are no measures taken to study whether these medical students understand the demands and priorities of a career in medicine once they decide to choose it. Hence the study was undertaken at PIMS-DU with Ist year MBBS students as participants. Aims: 1 Assess the factors influencing the choice of MBBS. 2 Analyze the prior knowledge and awareness of medical students regarding the course. 3 Their career trend in future. Material and Methods: All newly admitted students present at the orientation programme in September 2014 at PIMS –DU were included as participants. Their written responses to a 14 point questionnaire were entered into a Microsoft Excel Spreadsheet and descriptive analysis was done. Results: A majority of students had their parents and family members in medical profession indicating prior idea amongst the students regarding the course, even when the choice was made at an early stage of academics or without appearing for aptitude tests due to unawareness. Appearance for entrance exams to kept their options wide open but caused unnecessary stress, anxiety and economic burden to parents. However, these participants had limited knowledge about medical curriculum but had decisive ideas regarding future trend in career. Conclusions: Family being strong motivator for career choice for medical students; should encourage students to undertake aptitude tests, career guidance courses and investigate about future prospects to create a strong foundation as MBBS students.

  19. Thermal Shock and Oxidation Behavior of HiPIMS TiAlN Coatings Grown on Ti-48Al-2Cr-2Nb Intermetallic Alloy

    Directory of Open Access Journals (Sweden)

    Claudio Badini

    2016-11-01

    Full Text Available A High Power Impulse Magnetron Sputtering (HiPIMS method for depositing TiAlN environmental barrier coatings on the surface of Ti-48Al-2Cr-2Nb alloy was developed in view of their exploitation in turbine engines. Three differently engineered TiAlN films were processed and their performance compared. Bare intermetallic alloy coupons and coated specimens were submitted to thermal cycling under oxidizing atmosphere up to 850 °C or 950 °C, at high heating and cooling rates. For this purpose, a burner rig able to simulate the operating conditions of the different stages of turbine engines was used. Microstructures of the samples were compared before and after each test using several techniques (microscopy, XRD, and XPS. Coating-intermetallic substrate adhesion and tribological properties were investigated too. All the TiAlN films provided a remarkable increase in oxidation resistance. Good adhesion properties were observed even after repeated thermal shocks. HiPIMS pretreatments of the substrate surfaces performed before the coating deposition significantly affected the oxidation rate, the oxide layer composition and the coating/substrate adhesion.

  20. Comparison of ultrasound B-mode, strain imaging, acoustic radiation force impulse displacement and shear wave velocity imaging using real time clinical breast images

    Science.gov (United States)

    Manickam, Kavitha; Machireddy, Ramasubba Reddy; Raghavan, Bagyam

    2016-04-01

    It has been observed that many pathological process increase the elastic modulus of soft tissue compared to normal. In order to image tissue stiffness using ultrasound, a mechanical compression is applied to tissues of interest and local tissue deformation is measured. Based on the mechanical excitation, ultrasound stiffness imaging methods are classified as compression or strain imaging which is based on external compression and Acoustic Radiation Force Impulse (ARFI) imaging which is based on force generated by focused ultrasound. When ultrasound is focused on tissue, shear wave is generated in lateral direction and shear wave velocity is proportional to stiffness of tissues. The work presented in this paper investigates strain elastography and ARFI imaging in clinical cancer diagnostics using real time patient data. Ultrasound B-mode imaging, strain imaging, ARFI displacement and ARFI shear wave velocity imaging were conducted on 50 patients (31 Benign and 23 malignant categories) using Siemens S2000 machine. True modulus contrast values were calculated from the measured shear wave velocities. For ultrasound B-mode, ARFI displacement imaging and strain imaging, observed image contrast and Contrast to Noise Ratio were calculated for benign and malignant cancers. Observed contrast values were compared based on the true modulus contrast values calculated from shear wave velocity imaging. In addition to that, student unpaired t-test was conducted for all the four techniques and box plots are presented. Results show that, strain imaging is better for malignant cancers whereas ARFI imaging is superior than strain imaging and B-mode for benign lesions representations.

  1. An Insight into the Time Domain Phenomenon during the Transition Zone from Induction Motor to Synchronous Motor Mode for a Current Source Inverter Fed Synchronous Motor Drive System

    Directory of Open Access Journals (Sweden)

    A.B. Chattopadhyay

    2014-10-01

    Full Text Available Modeling of synchronous motor plays a dominant role in designing complicated drive system for different applications, especially large blower fans etc., for steel industries. As synchronous motor has no inherent starting torque generally it is started as an induction motor with the help of a damper winding and it pulls into synchronism under certain conditions. The present study exactly concentrates on this particular zone of transition from induction motor to synchronous motor mode for a current source inverter fed synchronous motor drive system. Due to complexity of synchronous motor in terms of number of windings and finite amount of air gap saliency, direct modeling of such transition zone in time domain becomes cumbersome at the first instance of modeling. That is why firstly the modeling is presented in complex frequency domain and then the time domain modeling is obtained by applying inverse Laplace transform technique. Apparently it seems to be a straight forward mathematical treatment but involvement of Convolution Integral for converting the formulation from s-domain to time domain becomes a matter of interest and it may draw the attention of various researchers working in this area. Furthermore the time domain response of the disturbance function may help a designer to fix up the time instant when the pull in phenomenon will be imposed by throwing the field winding to a DC supply.

  2. A Carbonaceous Membrane based on a Polymer of Intrinsic Microporosity (PIM-1) for Water Treatment

    Science.gov (United States)

    Kim, Hee Joong; Kim, Dong-Gyun; Lee, Kyuchul; Baek, Youngbin; Yoo, Youngjae; Kim, Yong Seok; Kim, Byoung Gak; Lee, Jong-Chan

    2016-01-01

    As insufficient access to clean water is expected to become worse in the near future, water purification is becoming increasingly important. Membrane filtration is the most promising technologies to produce clean water from contaminated water. Although there have been many studies to prepare highly water-permeable carbon-based membranes by utilizing frictionless water flow inside the carbonaceous pores, the carbon-based membranes still suffer from several issues, such as high cost and complicated fabrication as well as relatively low salt rejection. Here, we report for the first time the use of microporous carbonaceous membranes via controlled carbonization of polymer membranes with uniform microporosity for high-flux nanofiltration. Further enhancement of membrane performance is observed by O2 plasma treatment. The optimized membrane exhibits high water flux (13.30 LMH Bar−1) and good MgSO4 rejection (77.38%) as well as antifouling properties. This study provides insight into the design of microporous carbonaceous membranes for water purification. PMID:27782212

  3. What can we learn about HiPIMS process from the multidimensional plasma modeling?

    Science.gov (United States)

    Minea, Tiberiu

    2016-09-01

    The modeling of PVD process and especially magnetron plasma is widely reported. The novel way to excite the plasma applying to the cathode very high power pulses brings the temporal dimension to the system together with new phenomena. From the kinetic model of the dense plasma region, so called Ionization Region - IR, one can quantify the global behavior of the plasma parameters during the pulse. The most significant are the plasma composition, especially in the case of reactive gases, the fraction of back-attracted sputtered ions, the rarefaction due to wind effect, but also the discharge heating mechanisms and contribution to the discharge current. From the 2D particle modeling of the plasma new insights are revealed concerning the shape of the dense plasma region, the time evolution of the sheath, the electron energy distribution function, but also the characteristics of the diffusion plasma facing the substrate. Adding the third dimension to the model, the results reveal the complex transport of electrons especially in the azimuthal direction (instabilities and drifts), the formation of spokes and flares, and the strong relation between the secondary emission of electrons from the target and the plasma structuring. Warm thanks to Peter Awakowicz and Ante Hecimovic for inviting me to this GEC edition.

  4. A Carbonaceous Membrane based on a Polymer of Intrinsic Microporosity (PIM-1) for Water Treatment

    Science.gov (United States)

    Kim, Hee Joong; Kim, Dong-Gyun; Lee, Kyuchul; Baek, Youngbin; Yoo, Youngjae; Kim, Yong Seok; Kim, Byoung Gak; Lee, Jong-Chan

    2016-10-01

    As insufficient access to clean water is expected to become worse in the near future, water purification is becoming increasingly important. Membrane filtration is the most promising technologies to produce clean water from contaminated water. Although there have been many studies to prepare highly water-permeable carbon-based membranes by utilizing frictionless water flow inside the carbonaceous pores, the carbon-based membranes still suffer from several issues, such as high cost and complicated fabrication as well as relatively low salt rejection. Here, we report for the first time the use of microporous carbonaceous membranes via controlled carbonization of polymer membranes with uniform microporosity for high-flux nanofiltration. Further enhancement of membrane performance is observed by O2 plasma treatment. The optimized membrane exhibits high water flux (13.30 LMH Bar-1) and good MgSO4 rejection (77.38%) as well as antifouling properties. This study provides insight into the design of microporous carbonaceous membranes for water purification.

  5. On-line coupling of macroporous resin column chromatography with direct analysis in real time mass spectrometry utilizing a surface flowing mode sample holder.

    Science.gov (United States)

    Zeng, Shanshan; Wang, Lu; Chen, Teng; Qu, Haibin

    2014-02-06

    A surface flowing mode sample holder was designed as an alternative sampling strategy for direct analysis in real time mass spectrometry (DART-MS). With the sample holder, the on-line coupling of macroporous resin column chromatography with DART-MS was explored and the new system was employed to monitor the column chromatography elution process of Panax notoginseng. The effluent from macroporous resin column was first diluted and mixed with a derivatization reagent on-line, and the mixture was then directly transferred into the ionization region of DART-MS by the sample holder. Notoginsenosides were methylated and ionized in a metastable helium gas stream, and was introduced into MS for detection. The on-line system showed reasonable repeatability with a relative standard deviation of 12.3% for the peak area. Three notoginsenosides, i.e. notoginsenoside R1, ginsenoside Rb1 and ginsenoside Rg1, were simultaneously determined during the eluting process. The alteration of the chemical composition in the effluent was accurately identified in 9 min, agreeing well with the off-line analysis. The presented technique is more convenient compared to the traditional UPLC method. These results suggest that the surface flowing mode DART-MS has a good potential for the on-line process monitoring in the pharmaceutical industry.

  6. Monitoring of embryonic and fetal losses in different breeds of goats using real-time B-mode ultrasonography.

    Science.gov (United States)

    Samir, Haney; Karen, Aly; Ashmawy, Tarek; Abo-Ahmed, Mostafa; El-Sayed, Mohamed; Watanabe, Gen

    2016-01-15

    Compared to cattle and sheep, few studies had been undertaken to evaluate the incidence of embryonic and fetal losses (EFL) in goats. The objectives of the present study were to characterize the timing of EFL and to identify the factors that are associated with EFL in goats such as breed, age, parity, method of estrous synchronization, and breeding. Moreover, this study aimed to ensure whether a relationship existed between serum progesterone (P4) and EFL. Goats (n = 151) of different breeds (70 Zaraiebi, 42 Damascus, and 39 Cross goats [Baladi × Damascus]) were evaluated by ultrasonography to monitor EFL during different stages of gestation (D20-23, D26-29, D33-36, D40-45, and D47-54 after breeding). Blood samples were collected at D7, D20, and at each ultrasonographic scanning to clarify changes of serum P4 levels concurrently with EFL. Results revealed that 45 of 109 goats (41.28%) were exposed to EFL. A higher EFL % was observed between D20 to 23 and D47 to 54 (19.61%) compared with D47 to 54 to birth (11.76%). Moreover, a higher EFL % was observed in Zaraiebi goats compared with others. Age and goat parity had no significant effect on the EFL % in all goats. A high EFL % were observed in goats synchronized by P4 sponge, as well as artificially inseminated goats compared with goats with spontaneous estrus, and bred by natural mating, respectively. Serum P4 at D7 or D20 after breeding showed nonsignificant difference between normal pregnant goats and goats that experienced EFL. Unlike goats that experienced partial EFL, goats that experienced total EFL between D20 to 23 and D26 to 29 showed an abrupt P4 reduction (85.06%; P synchronization, breeding, and stage of pregnancy may be involved in EFL in goats. Therefore, improvement of the goat management in the early stage of pregnancy is important to decrease EFL % in goats. Although the P4 did not show any significant difference between normal pregnancy goats and goats that experienced EFL, CL disruption

  7. Real-time control of divertor detachment in H-mode with impurity seeding using Langmuir probe feedback in JET-ITER-like wall

    Science.gov (United States)

    Guillemaut, C.; Lennholm, M.; Harrison, J.; Carvalho, I.; Valcarcel, D.; Felton, R.; Griph, S.; Hogben, C.; Lucock, R.; Matthews, G. F.; Perez Von Thun, C.; Pitts, R. A.; Wiesen, S.; contributors, JET

    2017-04-01

    Burning plasmas with 500 MW of fusion power on ITER will rely on partially detached divertor operation to keep target heat loads at manageable levels. Such divertor regimes will be maintained by a real-time control system using the seeding of radiative impurities like nitrogen (N), neon or argon as actuator and one or more diagnostic signals as sensors. Recently, real-time control of divertor detachment has been successfully achieved in Type I ELMy H-mode JET-ITER-like wall discharges by using saturation current (I sat) measurements from divertor Langmuir probes as feedback signals to control the level of N seeding. The degree of divertor detachment is calculated in real-time by comparing the outer target peak I sat measurements to the peak I sat value at the roll-over in order to control the opening of the N injection valve. Real-time control of detachment has been achieved in both fixed and swept strike point experiments. The system has been progressively improved and can now automatically drive the divertor conditions from attached through high recycling and roll-over down to a user-defined level of detachment. Such a demonstration is a successful proof of principle in the context of future operation on ITER which will be extensively equipped with divertor target probes.

  8. Pixel multiplexing technique for real-time three-dimensional-imaging laser detection and ranging system using four linear-mode avalanche photodiodes.

    Science.gov (United States)

    Xu, Fan; Wang, Yuanqing; Li, Fenfang

    2016-03-01

    The avalanche-photodiode-array (APD-array) laser detection and ranging (LADAR) system has been continually developed owing to its superiority of nonscanning, large field of view, high sensitivity, and high precision. However, how to achieve higher-efficient detection and better integration of the LADAR system for real-time three-dimensional (3D) imaging continues to be a problem. In this study, a novel LADAR system using four linear mode APDs (LmAPDs) is developed for high-efficient detection by adopting a modulation and multiplexing technique. Furthermore, an automatic control system for the array LADAR system is proposed and designed by applying the virtual instrumentation technique. The control system aims to achieve four functions: synchronization of laser emission and rotating platform, multi-channel synchronous data acquisition, real-time Ethernet upper monitoring, and real-time signal processing and 3D visualization. The structure and principle of the complete system are described in the paper. The experimental results demonstrate that the LADAR system is capable of achieving real-time 3D imaging on an omnidirectional rotating platform under the control of the virtual instrumentation system. The automatic imaging LADAR system utilized only 4 LmAPDs to achieve 256-pixel-per-frame detection with by employing 64-bit demodulator. Moreover, the lateral resolution is ∼15 cm and range accuracy is ∼4 cm root-mean-square error at a distance of ∼40 m.

  9. Pixel multiplexing technique for real-time three-dimensional-imaging laser detection and ranging system using four linear-mode avalanche photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Fan; Wang, Yuanqing, E-mail: yqwang@nju.edu.cn; Li, Fenfang [School of Electronic Science and Engineering, Nanjing University, Nanjing 210046 (China)

    2016-03-15

    The avalanche-photodiode-array (APD-array) laser detection and ranging (LADAR) system has been continually developed owing to its superiority of nonscanning, large field of view, high sensitivity, and high precision. However, how to achieve higher-efficient detection and better integration of the LADAR system for real-time three-dimensional (3D) imaging continues to be a problem. In this study, a novel LADAR system using four linear mode APDs (LmAPDs) is developed for high-efficient detection by adopting a modulation and multiplexing technique. Furthermore, an automatic control system for the array LADAR system is proposed and designed by applying the virtual instrumentation technique. The control system aims to achieve four functions: synchronization of laser emission and rotating platform, multi-channel synchronous data acquisition, real-time Ethernet upper monitoring, and real-time signal processing and 3D visualization. The structure and principle of the complete system are described in the paper. The experimental results demonstrate that the LADAR system is capable of achieving real-time 3D imaging on an omnidirectional rotating platform under the control of the virtual instrumentation system. The automatic imaging LADAR system utilized only 4 LmAPDs to achieve 256-pixel-per-frame detection with by employing 64-bit demodulator. Moreover, the lateral resolution is ∼15 cm and range accuracy is ∼4 cm root-mean-square error at a distance of ∼40 m.

  10. Sliding Mode Control of a Class of Uncertain Nonlinear Time-Delay Systems Using LMI and TS Recurrent Fuzzy Neural Network

    Science.gov (United States)

    Chiang, Tung-Sheng; Chiu, Chian-Song

    This paper proposes the sliding mode control using LMI techniques and adaptive recurrent fuzzy neural network (RFNN) for a class of uncertain nonlinear time-delay systems. First, a novel TS recurrent fuzzy neural network (TS-RFNN) is developed to provide more flexible and powerful compensation of system uncertainty. Then, the TS-RFNN based sliding model control is proposed for uncertain time-delay systems. In detail, sliding surface design is derived to cope with the non-Isidori-Bynes canonical form of dynamics, unknown delay time, and mismatched uncertainties. Based on the Lyapunov-Krasoviskii method, the asymptotic stability condition of the sliding motion is formulated into solving a Linear Matrix Inequality (LMI) problem which is independent on the time-varying delay. Furthermore, the input coupling uncertainty is also taken into our consideration. The overall controlled system achieves asymptotic stability even if considering poor modeling. The contributions include: i) asymptotic sliding surface is designed from solving a simple and legible delay-independent LMI; and ii) the TS-RFNN is more realizable (due to fewer fuzzy rules being used). Finally, simulation results demonstrate the validity of the proposed control scheme.

  11. Rapid fingerprinting of sterols and related compounds in vegetable and animal oils and phytosterol enriched- margarines by transmission mode direct analysis in real time mass spectrometry.

    Science.gov (United States)

    Alberici, Rosana M; Fernandes, Gabriel D; Porcari, Andréia M; Eberlin, Marcos N; Barrera-Arellano, Daniel; Fernández, Facundo M

    2016-11-15

    Plant-derived sterols, often referred to as phytosterols, are important constituents of plant membranes where they assist in maintaining phospholipid bilayer stability. Consumption of phytosterols has been suggested to positively affect human health by reducing cholesterol levels in blood via inhibition of its absorption in the small intestine, thus protecting against heart attack and stroke. Sterols are challenging analytes for mass spectrometry, since their low polarity makes them difficult to ionize by both electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), typically requiring derivatization steps to overcome their low ionization efficiencies. We present a fast and reliable method to characterize the composition of phytosterols in vegetable oils and enriched margarines. The method requires no derivatization steps or sample extraction procedures thanks to the use of transmission mode direct analysis in real time mass spectrometry (TM-DART-MS). Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. 准时制生产方式的模拟实验研究%Research in Simulation Experiment of on Time Production Mode

    Institute of Scientific and Technical Information of China (English)

    汪和平; 李艳; 刘林

    2011-01-01

    为了有效地实施看板管理,应对地面生产线进行合理布局,设计出适合准时制生产方式模拟实验的生产看板和传送看板。本模拟实验有助于学生从理论和实践两方面掌握准时制生产方式的本质。%In order to effectively implement Kanban management,ground production limes is needed to be rationally laid out so as to design production Kanban and transmission Kanban,which helps students understand the nature of on time production mode.

  13. Assessment of mode-mixing and Herzberg-Teller effects on two-photon absorption and resonance hyper-Raman spectra from a time-dependent approach.

    Science.gov (United States)

    Ma, HuiLi; Zhao, Yi; Liang, WanZhen

    2014-03-07

    A time-dependent approach is presented to simulate the two-photon absorption (TPA) and resonance hyper-Raman scattering (RHRS) spectra including Duschinsky rotation (mode-mixing) and Herzberg-Teller (HT) vibronic coupling effects. The computational obstacles for the excited-state geometries, vibrational frequencies, and nuclear derivatives of transition dipole moments, which enter the expressions of TPA and RHRS cross sections, are further overcome by the recently developed analytical excited-state energy derivative approaches in the framework of time-dependent density functional theory. The excited-state potential curvatures are evaluated at different levels of approximation to inspect the effects of frequency differences, mode-mixing and HT on TPA and RHRS spectra. Two types of molecules, one with high symmetry (formaldehyde, p-difluorobenzene, and benzotrifluoride) and the other with non-centrosymmetry (cis-hydroxybenzylidene-2,3-dimethylimidazolinone in the deprotonated anion state (HDBI(-))), are used as test systems. The calculated results reveal that it is crucial to adopt the exact excited-state potential curvatures in the calculations of TPA and RHRS spectra even for the high-symmetric molecules, and that the vertical gradient approximation leads to a large deviation. Furthermore, it is found that the HT contribution is evident in the TPA and RHRS spectra of HDBI(-) although its one- and two-photon transitions are strongly allowed, and its effect results in an obvious blueshift of the TPA maximum with respect to the one-photon absorption maximum. With the HT and solvent effects getting involved, the simulated blueshift of 1291 cm(-1) agrees well with the experimental measurement.

  14. Assessment of mode-mixing and Herzberg-Teller effects on two-photon absorption and resonance hyper-Raman spectra from a time-dependent approach

    Energy Technology Data Exchange (ETDEWEB)

    Ma, HuiLi [State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and Institute of Fujian Provincial Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China); Department of Chemical Physics, University of Science and Technology of China, Hefei 230026 (China); Zhao, Yi; Liang, WanZhen, E-mail: liangwz@xmu.edu.cn [State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and Institute of Fujian Provincial Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)

    2014-03-07

    A time-dependent approach is presented to simulate the two-photon absorption (TPA) and resonance hyper-Raman scattering (RHRS) spectra including Duschinsky rotation (mode-mixing) and Herzberg-Teller (HT) vibronic coupling effects. The computational obstacles for the excited-state geometries, vibrational frequencies, and nuclear derivatives of transition dipole moments, which enter the expressions of TPA and RHRS cross sections, are further overcome by the recently developed analytical excited-state energy derivative approaches in the framework of time-dependent density functional theory. The excited-state potential curvatures are evaluated at different levels of approximation to inspect the effects of frequency differences, mode-mixing and HT on TPA and RHRS spectra. Two types of molecules, one with high symmetry (formaldehyde, p-difluorobenzene, and benzotrifluoride) and the other with non-centrosymmetry (cis-hydroxybenzylidene-2,3-dimethylimidazolinone in the deprotonated anion state (HDBI{sup −})), are used as test systems. The calculated results reveal that it is crucial to adopt the exact excited-state potential curvatures in the calculations of TPA and RHRS spectra even for the high-symmetric molecules, and that the vertical gradient approximation leads to a large deviation. Furthermore, it is found that the HT contribution is evident in the TPA and RHRS spectra of HDBI{sup −} although its one- and two-photon transitions are strongly allowed, and its effect results in an obvious blueshift of the TPA maximum with respect to the one-photon absorption maximum. With the HT and solvent effects getting involved, the simulated blueshift of 1291 cm{sup −1} agrees well with the experimental measurement.

  15. 时滞TCP网络的自适应滑模控制%Adaptive Sliding Mode Control for TCP Networks with Time-delay

    Institute of Scientific and Technical Information of China (English)

    叶成荫

    2011-01-01

    For the problem of congestion control in TCP networks with input-delay and state-delay, an active queue management algorithm is presented based on an adaptive sliding mode control. A particular linear transformation is used to turn the original time-delay system into a delay-free system and to eliminate the impact of time-delay.Considering the upper bound of the network system uncertainties may not be easily obtained, a simply adaptive law for the upper bound of system uncertainties is presented and a sliding mode controller is designed according to that adaptive law. The controller not only enables the queue length to converge to set value quickly but also keeps the queue oscillation small. Simulation results demonstrate that this algorithm can obtain good transient and steady state responses, and the algorithm is superior to the traditional PI control and sliding mode control.%针对具有输入时滞和状态时滞的TCP网络的拥塞控制问题,提出了一种基于自适应滑模控制的主动队列管理算法.通过引入一个特殊变换将原时滞系统转化为无时滞系统,从而消除时滞带来的影响.考虑到网络系统不确定性上界很难获得,提出了一种自适应律以适应系统的不确定的上界,并根据此自适应律设计了一个滑模控制器,所设计的控制器不仅可以使队列长度快速收敛到设定值,而且维持较小的队列振荡.仿真结果表明,该算法可以获得良好的暂态和稳态响应,该方法优于传统的PI控制和滑模控制.

  16. Paladin Integrated Management (PIM)

    Science.gov (United States)

    2015-12-01

    Defense Acquisition Program MILCON - Military Construction N/A - Not Applicable O&M - Operations and Maintenance ORD - Operational Requirements Document...to make significant changes to their Lean Manufacturing Process. These changes would increase cost to meet programmatic compliance requirements and

  17. Paladin Integrated Management (PIM)

    Science.gov (United States)

    2013-12-01

    DAMIR - Defense Acquisition Management Information Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense Switched Network...contractor support to Production Qualification Testing, Initial Operational Test and Evaluation ( IOT &E) and the Logistics Demonstration. In the FY 2015 PB...LRIP testing and the planned Logistics Demonstration. This reduced contractor support increases schedule risk for IOT &E and First Unit Equipped

  18. PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis

    Directory of Open Access Journals (Sweden)

    Guerra Susana M

    2009-06-01

    Full Text Available Abstract Background Polyenes represent a major class of antifungal agents characterised by the presence of a series of conjugated double bonds in their planar hydroxylated macrolide ring structure. Despite their general interest, very little is known about the factors that modulate their biosynthesis. Among these factors, we have recently discovered a new inducing compound (PI-factor in the pimaricin producer Streptomyces natalensis, which elicits polyene production in a manner characteristic of quorum sensing. Here, we describe the involvement of an amino-acid exporter from S. natalensis in modulating the expression of pimaricin biosynthetic genes via secretion of the quorum-sensing pimaricin-inducer PI-factor. Results Adjacent to the pimaricin gene cluster lies a member of the RhtB family of amino-acid exporters. Gene deletion and complementation experiments provided evidence for a role for PimT in the export of L-homoserine, L-serine, and L-homoserine lactone. Expression of the gene was shown to be induced by homoserine and by the quorum-sensing pimaricin-inducer PI-factor. Interestingly, the mutant displayed 65% loss of pimaricin production, and also 50% decrease in the production of PI, indicating that PimT is used as PI-factor exporter, and suggesting that the effect in antifungal production might be due to limited secretion of the inducer. Conclusion This report describes the involvement of an amino acid exporter (encoded by pimT in the vicinity of the pimaricin cluster in modulating the expression of antibiotic biosynthetic genes via secretion of the quorum-sensing pimaricin-inducer PI-factor. The discovery of the participation of amino acid exporters in a signal transduction cascade for the production of polyene macrolides is unexpected, and represents an important step forward towards understanding the regulatory network for polyene regulation. Additionally, this finding constitutes the first detailed characterization of an amino

  19. A Noise Reduction Method for Dual-Mass Micro-Electromechanical Gyroscopes Based on Sample Entropy Empirical Mode Decomposition and Time-Frequency Peak Filtering.

    Science.gov (United States)

    Shen, Chong; Li, Jie; Zhang, Xiaoming; Shi, Yunbo; Tang, Jun; Cao, Huiliang; Liu, Jun

    2016-05-31

    The different noise components in a dual-mass micro-electromechanical system (MEMS) gyroscope structure is analyzed in this paper, including mechanical-thermal noise (MTN), electronic-thermal noise (ETN), flicker noise (FN) and Coriolis signal in-phase noise (IPN). The structure equivalent electronic model is established, and an improved white Gaussian noise reduction method for dual-mass MEMS gyroscopes is proposed which is based on sample entropy empirical mode decomposition (SEEMD) and time-frequency peak filtering (TFPF). There is a contradiction in TFPS, i.e., selecting a short window length may lead to good preservation of signal amplitude but bad random noise reduction, whereas selecting a long window length may lead to serious attenuation of the signal amplitude but effective random noise reduction. In order to achieve a good tradeoff between valid signal amplitude preservation and random noise reduction, SEEMD is adopted to improve TFPF. Firstly, the original signal is decomposed into intrinsic mode functions (IMFs) by EMD, and the SE of each IMF is calculated in order to classify the numerous IMFs into three different components; then short window TFPF is employed for low frequency component of IMFs, and long window TFPF is employed for high frequency component of IMFs, and the noise component of IMFs is wiped off directly; at last the final signal is obtained after reconstruction. Rotation experimental and temperature experimental are carried out to verify the proposed SEEMD-TFPF algorithm, the verification and comparison results show that the de-noising performance of SEEMD-TFPF is better than that achievable with the traditional wavelet, Kalman filter and fixed window length TFPF methods.

  20. A Noise Reduction Method for Dual-Mass Micro-Electromechanical Gyroscopes Based on Sample Entropy Empirical Mode Decomposition and Time-Frequency Peak Filtering

    Directory of Open Access Journals (Sweden)

    Chong Shen

    2016-05-01

    Full Text Available The different noise components in a dual-mass micro-electromechanical system (MEMS gyroscope structure is analyzed in this paper, including mechanical-thermal noise (MTN, electronic-thermal noise (ETN, flicker noise (FN and Coriolis signal in-phase noise (IPN. The structure equivalent electronic model is established, and an improved white Gaussian noise reduction method for dual-mass MEMS gyroscopes is proposed which is based on sample entropy empirical mode decomposition (SEEMD and time-frequency peak filtering (TFPF. There is a contradiction in TFPS, i.e., selecting a short window length may lead to good preservation of signal amplitude but bad random noise reduction, whereas selecting a long window length may lead to serious attenuation of the signal amplitude but effective random noise reduction. In order to achieve a good tradeoff between valid signal amplitude preservation and random noise reduction, SEEMD is adopted to improve TFPF. Firstly, the original signal is decomposed into intrinsic mode functions (IMFs by EMD, and the SE of each IMF is calculated in order to classify the numerous IMFs into three different components; then short window TFPF is employed for low frequency component of IMFs, and long window TFPF is employed for high frequency component of IMFs, and the noise component of IMFs is wiped off directly; at last the final signal is obtained after reconstruction. Rotation experimental and temperature experimental are carried out to verify the proposed SEEMD-TFPF algorithm, the verification and comparison results show that the de-noising performance of SEEMD-TFPF is better than that achievable with the traditional wavelet, Kalman filter and fixed window length TFPF methods.