Haldusõiguserikkumise asja menetlus riigi keskkonnajärelvalve ametniku ja kohtuniku poolt : [bakalaureusetöö] / Hedy Mõtus-Vau ; Akadeemia Nord, õigusteaduskond ; juhendaja: Sirje Tromp

Index Scriptorium Estoniae

Mõtus-Vau, Hedy

2001-01-01

Järelevalveametniku tegevus haldusõiguserikkumise asja algatamisel ja protokolli koostamisel, asja arutamine; sama kohtuniku poolt. Otsused, edasikaebamine; järelevalveametniku ja kohtuniku erinev suhe haldusõiguserikkumise asjadesse. Olukord Soomes

A data acquisition system for real-time magnetic equilibrium reconstruction on ASDEX Upgrade and its application to NTM stabilization experiments

Energy Technology Data Exchange (ETDEWEB)

Giannone, L., E-mail: Louis.Giannone@ipp.mpg.de [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); Reich, M.; Maraschek, M.; Poli, E.; Rapson, C.; Barrera, L.; McDermott, R.; Mlynek, A. [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); Ruan, Q. [National Instruments, Austin, TX 78759-3504 (United States); Treutterer, W. [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); Wenzel, L. [National Instruments, Austin, TX 78759-3504 (United States); Bock, A.; Conway, G.; Fischer, R.; Fuchs, J.C.; Lackner, K. [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); McCarthy, P.J. [Department of Physics, University College Cork, Association EURATOM-DCU, Cork (Ireland); Preuss, R. [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); Rampp, M. [Computing Centre (RZG) of the Max Planck Society and the Max Planck Institute for Plasma Physics, 85748 Garching (Germany); Schuhbeck, K.H. [Max Planck Institute for Plasma Physics, EURATOM Association, 85748 Garching (Germany); and others

2013-12-15

Highlights: • Calculation of real-time tokamak magnetic equilibrium with constraints from magnetic probes. • Parallel equilibrium calculation including the Motional Stark Effect diagnostic as additional constraints. • Feedback control of mirror for pre-emptive ECCD stabilization of neo-classical tearing modes. • Probe calibration by individual poloidal field coil currents. • Optimized parameters for poloidal field coil location, integrator gains and the location and orientation of magnetic probes. -- Abstract: The pre-emptive stabilization of a neoclassical tearing mode, NTM, requires the calculation of the tokamak magnetic equilibrium in real-time. A launcher mirror is positioned to deposit electron cyclotron current drive on the rational surface where the NTM should appear. A real-time Grad–Shafranov solver using constraints from magnetic probe, flux loop and Motional Stark Effect measurements has been developed to locate these rational surfaces and deliver this information to the mirror controller in real-time. A novel algorithm significantly reduces the number of operations required in the first and second step of the solver. Contour integrals are carried out to calculate the q profile as a function of normalized radius and the rational surfaces are found by spline interpolation. A cycle time of 0.6 ms for calculating two tokamak equilibria in parallel using four current basis functions with magnetic constraints only and using six current basis functions with magnetic and MSE constraints has been achieved. Using these tools, pre-emptive stabilization of a m/n = 3/2 NTM mode in ASDEX Upgrade could be demonstrated.

Simulation of feedback control system for NTM stabilisation in ASDEX Upgrade

Energy Technology Data Exchange (ETDEWEB)

Rapson, Christopher, E-mail: chris.rapson@ipp.mpg.de [Max Planck Institute for Plasma Physics, EURATOM Association, Boltzmannstrasse 2, 85748 Garching (Germany); Monaco, Francesco; Reich, Matthias; Stober, Joerg; Treutterer, Wolfgang [Max Planck Institute for Plasma Physics, EURATOM Association, Boltzmannstrasse 2, 85748 Garching (Germany)

2013-10-15

Highlights: ► Feedback loop to control the ECRH deposition location is modelled in Simulink. Controller optimised using simulation results. ► Apart from optimising the PID gain values, alternative architectures were trialed without risk to hardware. ► Off-normal events could be simulated, and the controller response improved. ► Optimised controller applied in experiment. Even for the low power used, partial stabilisation of NTM was observed. ► The simulation is useful outside its intended application, and for future developments of the NTM feedback control system. -- Abstract: Neoclassical Tearing Modes (NTMs) are a class of MHD instability in high beta tokamak plasmas which significantly increase radial transport, thus capping the performance of fusion plasmas. More importantly, NTMs can lead to disruptions which compromise the lifetime of structural components. Several tokamaks have demonstrated that Electron Cyclotron Resonant Heating (ECRH) can stabilise NTMs if the power deposition is aligned with the mode location. The deposition location depends on the toroidal magnetic field, flux and density profiles, and can be controlled by tilting the mirror in the ECRH launcher. Until recently, the mirror angle was set by feedforward control at ASDEX Upgrade. In order to adapt automatically to different discharge scenarios, the system at ASDEX Upgrade has been extended to steer the mirror using feedback control. The mirror must react on the current diffusion time scale, on the order of 100 ms. This is within the capabilities of the mechanical subsystem and real-time plasma diagnostics, but requires careful interfacing between these components. For example, asynchronous data transfer and non-linearities make it difficult to design an analytically optimal controller. Therefore a simulation has been used to test and tune different controller architectures. This simulation is the subject of the current contribution. Performing the optimisation process offline

Complete Suppression of the m=2/n=1 NTM Using ECCD on DIII-D

International Nuclear Information System (INIS)

Petty, C.C.; La Haye, R.J.; Luce, T.C.; Humphreys, D.A.; Lohr, J.; Prater, R.; Austin, M.E.; Harvey, R.W.; Wade, M.R.

2003-01-01

Complete suppression of the m=2/n=1 neoclassical tearing mode (NTM) is reported for the first time using electron cyclotron current drive (ECCD) to noninductively generate current at the radius of the island O-point. Experiments on the DIII-D tokamak show that the maximum shrinkage of the m=2/n=1 island amplitude occurs when the ECCD location coincides with the q=2 surface. Estimates of the ECCD radial profile width from the island shrinkage are consistent with ray tracing calculations but may allow for a factor-of-1.5 broadening from electron radial transport

Andmete väljastamine sideettevõtjate poolt jälitus- ja julgeolekuasutustele ning teistele selleks õigustatud isikutele : [bakalaureusetöö] / Kati Ambo-Vaher ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

Index Scriptorium Estoniae

Ambo-Vaher, Kati

2007-01-01

Andmete väljastamise põhiseaduslikud piirangud ja isikuandmete kaitse, sideettevõtjate poolt andmete väljastamine jälitus- ja julgeolekuasutustele ning teistele selleks õigustatud isikutele, logifailide ja päringute säilitamise kohustus ning järelevalve, andmete väljastamisega kaasnevate kulude hüvitamine

Improved theory of forced magnetic reconnection due to error field and its application to seed island formation for NTM

International Nuclear Information System (INIS)

Ishizawa, A.; Tokuda, S.; Wakatani, M.

2001-01-01

A seed island is required for destabilizing the neo-classical tearing mode (NTM), which degrades confinement in long sustained, high-confinement, high beta plasmas. The seed island formation due to an MHD event, such as a sawtooth crash, is investigated by applying the improved boundary layer theory of forced magnetic reconnection. This improved theory introduces the non-constant-ψ matching and reveals the complicated feature of the reconnection described by two reconnected fluxes. In the initial evolution, these reconnected fluxes grow on the time scale including the ideal time scale, typical time scale of the MHD event and the time scale of resistive kink mode. The surface current is negative, Δ' (t) A S 1/3 . (author)

NTM stabilization by alternating O-point EC current drive using a high-power diplexer

Science.gov (United States)

Kasparek, W.; Doelman, N.; Stober, J.; Maraschek, M.; Zohm, H.; Monaco, F.; Eixenberger, H.; Klop, W.; Wagner, D.; Schubert, M.; Schütz, H.; Grünwald, G.; Plaum, B.; Munk, R.; Schlüter, K. H.; ASDEX Upgrade Team

2016-12-01

At the tokamak ASDEX Upgrade, experiments to stabilize neoclassical tearing modes (NTMs) by electron cyclotron (EC) heating and current drive in the O-points of the magnetic islands were performed. For the first time, injection into the O-points of the revolving islands was performed via a fast directional switch, which toggled the EC power between two launchers synchronously to the island rotation. The switching was performed by a resonant diplexer employing a sharp resonance in the transfer function, and a small frequency modulation of the feeding gyrotron around the slope of the resonance. Thus, toggling of the power between the two outputs of the diplexer connected to two articulating launchers was possible. Phasing and control of the modulation were performed via a set of Mirnov coils and appropriate signal processing. In the paper, technological issues, the design of the diplexer, the tracking of the diplexer resonance to the gyrotron frequency, the generation and processing of control signals for the gyrotron, and the typical performance concerning switching contrast and efficiency are discussed. The plasma scenario is described, and plasma experiments are presented, where the launchers scanned the region of the resonant surface continuously and also where the launchers were at a fixed position near to the q  =  1.5-surface. In the second case, complete stabilization of a 3/2 NTM could be reached. These experiments are also seen as a technical demonstration for the applicability of diplexers in large-scale ECRH systems.

Nontuberculous pulmonary mycobacteriosis in Denmark

DEFF Research Database (Denmark)

Andréjak, Claire; Thomsen, Vibeke Ø; Johansen, Isik Somuncu

2010-01-01

RATIONALE: Few population-based data are available regarding nontuberculous mycobacteria (NTM) pulmonary disease epidemiology and prognosis. OBJECTIVES: To examine NTM pulmonary colonization incidence, disease incidence, and prognostic factors. METHODS: All adults in Denmark with at least one NTM......-positive pulmonary specimen during 1997 to 2008 were identified using national medical databases and were categorized as having possible or definite NTM disease or colonization. MEASUREMENTS AND MAIN RESULTS: We calculated annual age-standardized NTM incidence rates and adjusted hazard ratios (HR) of death...... associated with patient age, sex, comorbidity, NTM species, and NTM disease status. Of 1,282 adults with 2,666 NTM-positive pulmonary specimens, 335 (26%) had definite NTM disease, 238 (19%) possible disease, and 709 (55%) colonization only. NTM incidence rates decreased until 2002, followed by an increase...

Basic rules for various liquids passing through nuclear track membranes

International Nuclear Information System (INIS)

Guo Shilun; Hao Xiuhong; Wang Yulan; Fan Zhongjun; Zhao Yuhua; Zhao Chongde

1995-01-01

The authors describes the new understanding obtained from the studies of NTM for various liquid media, including: (1) basic rule of pure liquids passing through NTM; (2) various methods for the determination of viscosity of liquids by NTM; (3) determination of solute concentration in various solutions by NTM; (4) rapid separation of mixed liquids and chemical separation by NTM; (5) blocking phenomenon of NTM by solid particles in liquids and the blocking formula; and (6) basic rules of filtration of bacteria by NTM

The epidemiology of pulmonary nontuberculous mycobacteria: data from a general hospital in Athens, Greece, 2007-2013.

Science.gov (United States)

Panagiotou, Marios; Papaioannou, Andriana I; Kostikas, Konstantinos; Paraskeua, Maria; Velentza, Ekaterini; Kanellopoulou, Maria; Filaditaki, Vasiliki; Karagiannidis, Napoleon

2014-01-01

The epidemiology of pulmonary nontuberculous mycobacteria (NTM) in Greece is largely unknown. To determine the incidence and the demographic, microbiological, and clinical characteristics of patients with pulmonary NTM infection and pulmonary NTM disease. A retrospective review of the demographic, microbiological, and clinical characteristics of patients with NTM culture-positive respiratory specimens from January 2007 to May 2013. A total of 120 patients were identified with at least one respiratory NTM isolate and 56 patients (46%) fulfilled the microbiological ATS/IDSA criteria for NTM disease. Of patients with adequate data, 16% fulfilled the complete ATS/IDSA criteria for NTM disease. The incidence of pulmonary NTM infection and disease was 18.9 and 8.8 per 100.000 inpatients and outpatients, respectively. The spectrum of NTM species was high (13 species) and predominated by M. avium-intracellulare complex (M. avium (13%), M. intracellulare (10%)), M. gordonae (14%), and M. fortuitum (12%). The ratio of isolation of NTM to M. tuberculosis in all hospitalized patients was 0.59. The first data on the epidemiology of pulmonary NTM in Athens, Greece, are presented. NTM infection is common in patients with chronic respiratory disease. However, only a significantly smaller proportion of patients fulfill the criteria for NTM disease.

The Epidemiology of Pulmonary Nontuberculous Mycobacteria: Data from a General Hospital in Athens, Greece, 2007–2013

Science.gov (United States)

Papaioannou, Andriana I.; Paraskeua, Maria; Velentza, Ekaterini; Kanellopoulou, Maria; Filaditaki, Vasiliki; Karagiannidis, Napoleon

2014-01-01

Background. The epidemiology of pulmonary nontuberculous mycobacteria (NTM) in Greece is largely unknown. Objectives. To determine the incidence and the demographic, microbiological, and clinical characteristics of patients with pulmonary NTM infection and pulmonary NTM disease. Methods. A retrospective review of the demographic, microbiological, and clinical characteristics of patients with NTM culture-positive respiratory specimens from January 2007 to May 2013. Results. A total of 120 patients were identified with at least one respiratory NTM isolate and 56 patients (46%) fulfilled the microbiological ATS/IDSA criteria for NTM disease. Of patients with adequate data, 16% fulfilled the complete ATS/IDSA criteria for NTM disease. The incidence of pulmonary NTM infection and disease was 18.9 and 8.8 per 100.000 inpatients and outpatients, respectively. The spectrum of NTM species was high (13 species) and predominated by M. avium-intracellulare complex (M. avium (13%), M. intracellulare (10%)), M. gordonae (14%), and M. fortuitum (12%). The ratio of isolation of NTM to M. tuberculosis in all hospitalized patients was 0.59. Conclusions. The first data on the epidemiology of pulmonary NTM in Athens, Greece, are presented. NTM infection is common in patients with chronic respiratory disease. However, only a significantly smaller proportion of patients fulfill the criteria for NTM disease. PMID:25132991

An unusual outbreak of nontuberculous mycobacteria in hospital respiratory wards: Association with nontuberculous mycobacterial colonization of hospital water supply network

Directory of Open Access Journals (Sweden)

Salvatore D′Antonio

2016-01-01

Full Text Available The incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM infection is increasing worldwide arousing concerns that NTM infection may become a serious health challenge. We recently observed a significant increase of NTM-positive sputa samples from patients referred to respiratory disease wards of a large tertiary hospital in Rome. A survey to identify possible NTM contamination revealed a massive presence of NTM in the hospital water supply network. After decontamination procedures, NTM presence dropped both in water pipelines and sputa samples. We believe that this observation should encourage water network surveys for NTM contamination and prompt decontamination procedures should be considered to reduce this potential source of infection.

Non-tuberculous mycobacteria: baseline data from three sites in Papua New Guinea, 2010-2012.

Science.gov (United States)

Ley, Serej; Carter, Robyn; Millan, Korai; Phuanukoonnon, Suparat; Pandey, Sushil; Coulter, Christopher; Siba, Peter; Beck, Hans-Peter

2015-01-01

To determine the proportion of non-tuberculous mycobacteria (NTM) in samples of pulmonary tuberculosis (TB) cases from Papua New Guinea who were diagnosed using acid-fast microscopy. As part of a case detection study for TB, conducted in three provincial hospitals in Papua New Guinea, sputum samples of suspected tuberculous cases aged 15 years or older were collected from November 2010 to July 2012. Mycobacterial species isolated from sputum and grown in culture were examined to distinguish between NTM and the Mycobacterium tuberculosis complex (MTBC). NTM were detected in 4% (9/225) of sputum samples grown in culture. Five (2.2%) of them were identified as NTM only and four (1.8%) were identified as mixed cultures containing both MTBC and NTM. Four different NTM species were identified; M. fortuitum, M. intracellulare, M. terrae and M. avium. This is the first report from Papua New Guinea identifying NTM in three different locations. As NTM cannot be distinguished from M. tuberculosis through smear microscopy, the presence of NTM can lead to a false-positive diagnosis of tuberculosis. The prevalence of NTM should be determined and a diagnostic algorithm developed to confirm acid-fast bacilli in a smear as M. tuberculosis.

Non-tuberculous mycobacteria: baseline data from three sites in Papua New Guinea, 2010–2012

Science.gov (United States)

Ley, Serej; Carter, Robyn; Millan, Korai; Phuanukoonnon, Suparat; Pandey, Sushil; Coulter, Christopher; Siba, Peter

2015-01-01

Objective To determine the proportion of non-tuberculous mycobacteria (NTM) in samples of pulmonary tuberculosis (TB) cases from Papua New Guinea who were diagnosed using acid-fast microscopy. Methods As part of a case detection study for TB, conducted in three provincial hospitals in Papua New Guinea, sputum samples of suspected tuberculous cases aged 15 years or older were collected from November 2010 to July 2012. Mycobacterial species isolated from sputum and grown in culture were examined to distinguish between NTM and the Mycobacterium tuberculosis complex (MTBC). Results NTM were detected in 4% (9/225) of sputum samples grown in culture. Five (2.2%) of them were identified as NTM only and four (1.8%) were identified as mixed cultures containing both MTBC and NTM. Four different NTM species were identified; M. fortuitum, M. intracellulare, M. terrae and M. avium. Discussion This is the first report from Papua New Guinea identifying NTM in three different locations. As NTM cannot be distinguished from M. tuberculosis through smear microscopy, the presence of NTM can lead to a false-positive diagnosis of tuberculosis. The prevalence of NTM should be determined and a diagnostic algorithm developed to confirm acid-fast bacilli in a smear as M. tuberculosis. PMID:26798558

Comparison of clinical and laboratory findings between those with pulmonary tuberculosis and those with nontuberculous mycobacterial lung disease.

Science.gov (United States)

Thanachartwet, Vipa; Desakorn, Varunee; Duangrithi, Duangjai; Chunpongthong, Pongsak; Phojanamongkolkij, Kamol; Jitruckthai, Pasakorn; Kasetjaroen, Yuttichai; Pitisuttithum, Punnee

2014-01-01

In tuberculosis endemic areas, patients with sputum positive for acid-fast bacilli (AFB) are usually diagnosed and treated for pulmonary tuberculosis. The diagnosis of nontuberculous mycobacteria (NTM) lung disease is often ascertained only after lung disease progression occurs, increasing the risk of severe morbidity and mortality. We conducted a matched case-control study among a prospective cohort of 300 patients with newly diagnosed AFB-positive sputum in Thailand during 2010-2012. We compared clinical and laboratory parameters and outcomes among patients with pulmonary tuberculosis, NTM lung disease and NTM colonization. A mycobacterial culture was performed in all patients. Ten patients with NTM lung disease were compared to 50 patients with pulmonary tuberculosis and 10 patients with NTM colonization. The presence of diabetes mellitus or human immunodeficiency virus infection, were associated with NTM lung disease (p = 0.030). Patients with NTM lung disease had a significantly lower body weight prior to treatment (p = 0.021), a higher body weight change from baseline (p = 0.038), and were more likely to have cavitations on chest radiograph (p = 0.033) than those with NTM colonization. In tuberculosis endemic areas, mycobacterial identification should be performed among patients with impaired immune function. NTM lung disease treatment should be considered in patients with NTM sputum isolates who have a history of significant weight loss or cavitations on chest radiography.

Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century

DEFF Research Database (Denmark)

Hermansen, Thomas S; Ravn, Pernille; Svensson, Erik

2017-01-01

and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the International Reference Laboratory of Mycobacteriology in Denmark. Among these, 8,227 NTM strains were identified from 3,462 patients and distributed according to microbiological...... disease criteria. We observed no increase in NTM disease incidence or proportion of patients with positive NTM cultures during the study period (Quasi-Poisson regression, p = 0.275 and 0.352 respectively). Annual incidence rates were 1.20/105 for definite NTM disease, 0.49/105 for possible NTM disease...... and 0.88/105 for NTM colonization. The incidence rate of NTM disease was highest in children aged 0-4 years (5.36/105/year), predominantly with cervical Mycobacterium avium complex (MAC) adenitis. Surprisingly, based on more than half a million clinical specimens cultured for mycobacteria in Denmark...

Recent advances on nontuberculous mycobacteria diseases in Asia

Directory of Open Access Journals (Sweden)

Po-Ren Hsueh

2015-01-01

Full Text Available The isolation rate of nontuberculous mycobacteria (NTM species and the prevalence of NTM-associated diseases are on the rise worldwide; however, the species distribution of NTM isolates and the types of diseases caused by NTM species vary from region to region. Treatment of a NTM disease is complicated, and there is no comprehensive guideline regarding the in vitro susceptibility of each antimicrobial agent against NTM. Therefore, appropriate anti-NTM treatment can only be recommended based on individual NTM species and local surveillance studies of anti-NTM resistance. Previous studies on the in vitro susceptibility of Mycobacterium avium complex (MAC to clarithromycin in some Asian countries have revealed a low rate of resistance to that antimicrobial agent. Thus, a clarithromycin-based anti-MAC regimen should be effective for MAC infections. However, clarithromycin resistance due to the mutation of the 23S rRNA gene in MAC strains has been detected in many countries. Therefore, physicians should avoid monotherapy with clarithromycin and consider the possibility of clarithromycin resistance in patients who do not respond to clarithromycin-based regimens. Rifampicin is the critical component of successful management of Mycobacterium kansasii diseases. Although most M. kansasii isolates are susceptible to rifampicin in Western countries and in Japan, this agent may not work well in Taiwan. Rapidly growing mycobacteria (RGM is a prevalent NTM group worldwide, particularly in Asia; however, each NTM species in this group may have its own distinct antibiotic susceptibility pattern, and close monitoring of the antibiotic-resistance patterns of RGM is necessary. Most important of all, the in vitro susceptibility may not represent the in vivo activity until the confirmation of the clinical study. Therefore, further investigation of the clinical effectiveness of the anti-NTM agents is warranted.

Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century

DEFF Research Database (Denmark)

Hermansen, Thomas S; Ravn, Pernille; Svensson, Erik

2017-01-01

and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the International Reference Laboratory of Mycobacteriology in Denmark. Among these, 8,227 NTM strains were identified from 3,462 patients and distributed according to microbiological...... disease criteria. We observed no increase in NTM disease incidence or proportion of patients with positive NTM cultures during the study period (Quasi-Poisson regression, p = 0.275 and 0.352 respectively). Annual incidence rates were 1.20/10(5) for definite NTM disease, 0.49/10(5) for possible NTM disease...... and 0.88/10(5) for NTM colonization. The incidence rate of NTM disease was highest in children aged 0-4 years (5.36/10(5)/year), predominantly with cervical Mycobacterium avium complex (MAC) adenitis. Surprisingly, based on more than half a million clinical specimens cultured for mycobacteria in Denmark...

Real-time mirror steering for improved closed loop neoclassical tearing mode suppression by electron cyclotron current drive in DIII-D

Energy Technology Data Exchange (ETDEWEB)

Kolemen, E., E-mail: ekolemen@pppl.gov [Princeton Plasma Physics Laboratory, PO Box 45, Princeton, NJ 08543-0451 (United States); Ellis, R. [Princeton Plasma Physics Laboratory, PO Box 45, Princeton, NJ 08543-0451 (United States); La Haye, R.J.; Humphreys, D.A.; Lohr, J.; Noraky, S.; Penaflor, B.G.; Welander, A.S. [General Atomics, PO Box 85608, San Diego, CA 92186-5608 (United States)

2013-11-15

Highlights: • We developed neoclassical tearing mode (NTM) control system for DIII-D, which uses six sets of real-time steerable mirrors in order to move the electron cyclotron current drive (ECCD) deposition location in plasma. • This algorithm accurately finds the NTM island location employing motional Stark effect EFIT MHD equilibrium reconstruction. • Successful NTM suppression and preemption has been achieved in DIII-D using this control system to automatically switches on and off gyrotrons when NTM is detected and rapidly align the NTM island and the ECCD deposition location. -- Abstract: The development and operation of the neoclassical tearing mode (NTM) avoidance and control system for DIII-D, which uses six sets of real-time steerable mirrors in order to move the electron cyclotron current drive (ECCD) deposition location in plasma, is described. The real-time DIII-D NTM control algorithm residing in the Plasma Control System (PCS) automatically detects an NTM by analysis of the Mirnov diagnostics, employs motional Stark effect (MSE) EFIT MHD equilibrium reconstruction to locate the rational q-surface where the NTM island can be found, then calculates the appropriate mirror position for alignment of the ECCD with the island using ray tracing. The control commands from PCS are sent to the electron cyclotron system to switch on and off or modulate the gyrotrons and to the steerable mirror system to move the steerable mirrors to the requested positions. Successful NTM suppression has been achieved in DIII-D using this control system to rapidly align the NTM island and the ECCD deposition location, and to actively maintain the alignment as plasma conditions change.

Nontuberculous Mycobacteria Infections at a Provincial Reference Hospital, Cambodia.

Science.gov (United States)

Bonnet, Maryline; San, Kim Chamroeun; Pho, Yati; Sok, Chandara; Dousset, Jean-Philippe; Brant, William; Hurtado, Northan; Eam, Khun Kim; Ardizzoni, Elisa; Heng, Seiha; Godreuil, Sylvain; Yew, Wing-Wai; Hewison, Cathy

2017-07-01

Prevalence of nontuberculous mycobacteria (NTM) disease is poorly documented in countries with high prevalence of tuberculosis (TB). We describe prevalence, risk factors, and TB program implications for NTM isolates and disease in Cambodia. A prospective cohort of 1,183 patients with presumptive TB underwent epidemiologic, clinical, radiologic, and microbiologic evaluation, including >12-months of follow-up for patients with NTM isolates. Prevalence of NTM isolates was 10.8% and of disease was 0.9%; 217 (18.3%) patients had TB. Of 197 smear-positive patients, 171 (86.8%) had TB confirmed (167 by culture and 4 by Xpert MTB/RIF assay only) and 11 (5.6%) had NTM isolates. HIV infection and past TB were independently associated with having NTM isolates. Improved detection of NTM isolates in Cambodia might require more systematic use of mycobacterial culture and the use of Xpert MTB/RIF to confirm smear-positive TB cases, especially in patients with HIV infection or a history of TB.

Specific Proteins in Nontuberculous Mycobacteria: New Potential Tools

Directory of Open Access Journals (Sweden)

Patricia Orduña

2015-01-01

Full Text Available Nontuberculous mycobacteria (NTM have been isolated from water, soil, air, food, protozoa, plants, animals, and humans. Although most NTM are saprophytes, approximately one-third of NTM have been associated with human diseases. In this study, we did a comparative proteomic analysis among five NTM strains isolated from several sources. There were different numbers of protein spots from M. gordonae (1,264, M. nonchromogenicum type I (894, M. nonchromogenicum type II (935, M. peregrinum (806, and M. scrofulaceum/Mycobacterium mantenii (1,486 strains, respectively. We identified 141 proteins common to all strains and specific proteins to each NTM strain. A total of 23 proteins were selected for its identification. Two of the common proteins identified (short-chain dehydrogenase/reductase SDR and diguanylate cyclase did not align with M. tuberculosis complex protein sequences, which suggest that these proteins are found only in the NTM strains. Some of the proteins identified as common to all strains can be used as markers of NTM exposure and for the development of new diagnostic tools. Additionally, the specific proteins to NTM strains identified may represent potential candidates for the diagnosis of diseases caused by these mycobacteria.

APPLICATION OF NEOTAME IN CATCHUP: DEVELOPMENT OF PROTOTYPES AND SENSORY STUDIES

Directory of Open Access Journals (Sweden)

G. C. M. C. BANNWART

2008-11-01

Full Text Available

In the present study, fi ve prototypes of catchup were developed, using the sweetener Neotame (NTM as a total or partial replacer for sucrose. Initially, the ideal sweetness of NTM in this application was determined using just-about-right scale. Then, difference and preference tests were carried out to verify the effects of the substitution of sucrose by NTM, at different levels. Time-intensity studies were also performed for the attributes sweetness and tomato fl avor. The results showed that the ideal sweetness of NTM in catchup as the only sweetener is around 9.33 ppm. The substitution of sucrose for NTM is only signifi cantly perceived for the prototypes sweetened with 25:75 sucrose:NTM and 100% NTM, which were the only ones that were less preferred than the control (100% sucrose. The time-intensity studies confi rmed that the prototypes containing combinations of sucrose and NTM are similar in terms of sweetness perception, independently of the proportions. Based on the results, it was concluded that NTM is a suitable sweetener for catchup, in reducedsugar versions, as it can replace up to 50% of sucrose without negative effects on the product´s sensory properties.

High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy

International Nuclear Information System (INIS)

McEvoy, Sinead; Lavelle, Lisa; Kilcoyne, Aoife; McCarthy, Colin; Dodd, Jonathan D.; DeJong, Pim A.; Loeve, Martine; Tiddens, Harm A.W.M.; McKone, Edward; Gallagher, Charles G.

2012-01-01

To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) for the detection of nontuberculous mycobacterium infection (NTM) in adult cystic fibrosis (CF) patients. Twenty-seven CF patients with sputum-culture-proven NTM (NTM+) underwent HRCT. An age, gender and spirometrically matched group of 27 CF patients without NTM (NTM-) was included as controls. Images were randomly and blindly analysed by two readers in consensus and scored using a modified Bhalla scoring system. Significant differences were seen between NTM (+) and NTM (-) patients in the severity of the bronchiectasis subscore [45 % (1.8/4) vs. 35 % (1.4/4), P = 0.029], collapse/consolidation subscore [33 % (1.3/3) vs. 15 % (0.6/3)], tree-in-bud/centrilobular nodules subscore [43 % (1.7/3) vs. 25 % (1.0/3), P = 0.002] and the total CT score [56 % (18.4/33) vs. 46 % (15.2/33), P = 0.002]. Binary logistic regression revealed BMI, peribronchial thickening, collapse/consolidation and tree-in-bud/centrilobular nodules to be predictors of NTM status (R 2 = 0.43). Receiver-operator curve analysis of the regression model showed an area under the curve of 0.89, P < 0.0001. In adults with CF, seven or more bronchopulmonary segments showing tree-in-bud/centrilobular nodules on HRCT is highly suggestive of NTM colonisation. (orig.)

High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy

Energy Technology Data Exchange (ETDEWEB)

McEvoy, Sinead; Lavelle, Lisa; Kilcoyne, Aoife; McCarthy, Colin; Dodd, Jonathan D. [St. Vincent' s University Hospital, Department of Radiology, Dublin (Ireland); DeJong, Pim A. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Loeve, Martine; Tiddens, Harm A.W.M. [Erasmus MC-Sophia Children' s Hospital, Department of Radiology, Department of Pediatric Pulmonology and Allergology, Rotterdam (Netherlands); McKone, Edward; Gallagher, Charles G. [St. Vincent' s University Hospital, Department of Respiratory Medicine and National Referral Centre for Adult Cystic Fibrosis, Dublin (Ireland)

2012-12-15

To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) for the detection of nontuberculous mycobacterium infection (NTM) in adult cystic fibrosis (CF) patients. Twenty-seven CF patients with sputum-culture-proven NTM (NTM+) underwent HRCT. An age, gender and spirometrically matched group of 27 CF patients without NTM (NTM-) was included as controls. Images were randomly and blindly analysed by two readers in consensus and scored using a modified Bhalla scoring system. Significant differences were seen between NTM (+) and NTM (-) patients in the severity of the bronchiectasis subscore [45 % (1.8/4) vs. 35 % (1.4/4), P = 0.029], collapse/consolidation subscore [33 % (1.3/3) vs. 15 % (0.6/3)], tree-in-bud/centrilobular nodules subscore [43 % (1.7/3) vs. 25 % (1.0/3), P = 0.002] and the total CT score [56 % (18.4/33) vs. 46 % (15.2/33), P = 0.002]. Binary logistic regression revealed BMI, peribronchial thickening, collapse/consolidation and tree-in-bud/centrilobular nodules to be predictors of NTM status (R{sup 2} = 0.43). Receiver-operator curve analysis of the regression model showed an area under the curve of 0.89, P < 0.0001. In adults with CF, seven or more bronchopulmonary segments showing tree-in-bud/centrilobular nodules on HRCT is highly suggestive of NTM colonisation. (orig.)

Review and meta analysis of nontuberculous mycobacteria in the Middle East

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Sanaz Rahideh

2015-01-01

Conclusion: This is the first study reporting NTM species in the Middle East. In summary, this review demonstrates that the frequency of NTM has increased in this region. In addition to the limitations of the NTM study in some countries of the Middle East, there is an urgent need to develop laboratory methods for NTM identification to prepare a comprehensive report for this region.

Prevalence and species spectrum of both pulmonary and extrapulmonary nontuberculous mycobacteria isolates at a tertiary care center

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Jyoti Umrao

2016-01-01

Full Text Available Objective/background: Nontuberculous mycobacteria (NTM infection associated with pulmonary and extrapulmonary disease has been increasing globally. Despite an increase in incidence rate of NTM infection, its prevalence, species diversity, and circulation pattern in India is largely unknown. This study sought to investigate the overall burden and diversity of NTM among both pulmonary and extrapulmonary clinical isolates from a Northern Indian population. Methods: The study was conducted in the Department of Microbiology, from January 2013 to December 2015. A total of 4620 clinical samples were collected from patients suspected to have pulmonary and extrapulmonary tuberculosis. Preliminary diagnosis was performed using Ziehl–Neelsen staining followed by liquid culture in BacT/ALERT three-dimensional system. A total of 906 positive cultures obtained were differentiated as either NTM or Mycobacterium tuberculosis complex using a biochemical and MPT64 antigen test. Further identification of NTM species was confirmed with a line probe assay. Results: Out of 906 cultures isolates, 263 (29.0% were confirmed as NTM and 643 (71.0% were identified as Mycobacterium tuberculosis complex. A total of 79.4% of the NTM were recovered from pulmonary and 18.2% from extrapulmonary specimens. The diversity of NTM species was high (13 species and predominated by Mycobacterium abscessus (31.3% followed by Mycobacterium fortuitum (22%, Mycobacterium intracellulare (13.6%, Mycobacterium chelonae (9.1%, however, M. abscessus and M. fortuitum were the predominant species in both types of clinical isolates. Men (60.4% and older patients aged greater than 55 years were the predominated risk group for NTM infection. Conclusion: The high prevalence and species diversity of NTM suggests the need for immediate and accurate characterization of NTM for proper treatment and management of patients.

Non-Tuberculous Mycobacteria and the Performance of Interferon Gamma Release Assays in Denmark

DEFF Research Database (Denmark)

Hermansen, Thomas Stig; Thomsen, Vibeke Østergaard; Lillebaek, Troels

2014-01-01

, nationwide patient data on positive NTM cultures (n = 925) were combined with nationwide data on QFT results (n = 16,133), both retrieved from the International Reference Laboratory of Mycobacteriology, Denmark. A total of 112 patients with NTM infections had a QFT performed, 53 patients had definite NTM...... disease, 10 had possible disease and 49 had NTM colonization. RESULTS: QFT was positive in 8% (4/53) of patients with definite disease, 40% (4/10) with possible disease and 31% (15/49) with colonization. Positivity rate was lowest among patients with definite disease infected with NTM without the RD1...

Distribution of nontuberculous mycobacteria in treated patients with pulmonary disease in Greece - relation to microbiological data.

Science.gov (United States)

Manika, Katerina; Tsikrika, Stamatoula; Tsaroucha, Emilia; Karabela, Simona; Karachaliou, Iris; Bosmi, Ioulia; Kioumis, Ioannis; Papavasileiou, Apostolos

2015-01-01

The aim was to assess the distribution of nontuberculous mycobacteria (NTM) in treated patients with pulmonary disease (PD) in Greece. Patients treated for NTM PD at the two largest chest diseases hospitals in Greece, in the period 1990-2013 were investigated. For the years 2005-2013 data on NTM isolation frequency were recorded. M. avium complex (MAC) was the predominant cause of NTM PD disease followed by M. kansasii and rapid growing mycobacteria (RGM). The pathogenicity of RGM was significantly lower than this of MAC and M. kansasii. An increase was observed in the percentage of isolated NTM species that were considered clinically significant over the study period. The increasing number of NTM PD in Greece is a consequence of their isolation being more frequently considered as clinically relevant.

A novel turbulence trigger for neoclassical tearing modes in tokamaks

International Nuclear Information System (INIS)

Itoh, Sanae-I.; Yagi, Masatoshi; Itoh, Kimitaka

2003-07-01

Stochastic trigger by microturbulence for neoclassical tearing mode (NTM) is studied. NTM induces topological change of magnetic structure and has subcritical nature. Transition rate of probability density function for and statistically-averaged amplitude of NTM are obtained. Boundary in the phase diagram is determined as the statistical long time average of the transition conditions. NTM can be excited by crossing this boundary even in the absence of other global instabilities. (author)

Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance

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Ali Akbar Velayati

2015-01-01

Full Text Available Nontuberculous mycobacteria (NTM are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65% studies focused on NTM isolates from clinical specimens, 6 (30% studies examined NTM isolates from environmental samples, and one (5% article included both clinical and environmental isolates. M. fortuitum (229/997; 23% was recorded as the most prevalent and rapid growing mycobacteria (RGM species in both clinical (28% and environmental (19% isolated samples (P < 0.05. Among slow growing mycobacteria (SGM, M. simiae (103/494; 21% demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%. These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance.

Science.gov (United States)

Velayati, Ali Akbar; Farnia, Parissa; Mozafari, Mohadese; Mirsaeidi, Mehdi

2015-01-01

Nontuberculous mycobacteria (NTM) are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65%) studies focused on NTM isolates from clinical specimens, 6 (30%) studies examined NTM isolates from environmental samples, and one (5%) article included both clinical and environmental isolates. M. fortuitum (229/997; 23%) was recorded as the most prevalent and rapid growing mycobacteria (RGM) species in both clinical (28%) and environmental (19%) isolated samples (P < 0.05). Among slow growing mycobacteria (SGM), M. simiae (103/494; 21%) demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%). These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

Application of PROMETHEE-GAIA method for non-traditional machining processes selection

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Prasad Karande

2012-10-01

Full Text Available With ever increasing demand for manufactured products of hard alloys and metals with high surface finish and complex shape geometry, more interest is now being paid to non-traditional machining (NTM processes, where energy in its direct form is used to remove material from workpiece surface. Compared to conventional machining processes, NTM processes possess almost unlimited capabilities and there is a strong believe that use of NTM processes would go on increasing in diverse range of applications. Presence of a large number of NTM processes along with complex characteristics and capabilities, and lack of experts in NTM process selection domain compel for development of a structured approach for NTM process selection for a given machining application. Past researchers have already attempted to solve NTM process selection problems using various complex mathematical approaches which often require a profound knowledge in mathematics/artificial intelligence from the part of process engineers. In this paper, four NTM process selection problems are solved using an integrated PROMETHEE (preference ranking organization method for enrichment evaluation and GAIA (geometrical analysis for interactive aid method which would act as a visual decision aid to the process engineers. The observed results are quite satisfactory and exactly match with the expected solutions.

Increasing Recovery of Nontuberculous Mycobacteria from Respiratory Specimens over a 10-Year Period in a Tertiary Referral Hospital in South Korea.

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Koh, Won-Jung; Chang, Boksoon; Jeong, Byeong-Ho; Jeon, Kyeongman; Kim, Su-Young; Lee, Nam Yong; Ki, Chang-Seok; Kwon, O Jung

2013-11-01

The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. During the study period, 32,841 respiratory specimens from 10,563 patients were found to be culture-positive for mycobacteria. These included 12,619 (38%) Mycobacterium tuberculosis and 20,222 (62%) NTM isolates. The proportion of NTM among all positive mycobacterial cultures increased from 43% (548/1,283) in 2001 to 70% (3,341/4,800) in 2011 (ptrend). The recovery rate of NTM isolates from acid-fast bacilli smear-positive specimens increased from 9% (38/417) in 2001 to 64% (1,284/1,997) in 2011 (ptrend). The proportion of positive liquid cultures was higher for NTM than for M. tuberculosis (p<0.001). The most frequently isolated NTM were Mycobacterium avium-intracellulare complex (53%) and Mycobacterium abscessus-massiliense complex (25%). The recovery rate of NTM from respiratory specimens in South Korea has increased steadily.

Nontuberculous mycobacteria in Middle East: Current situation and future challenges

OpenAIRE

Velayati, Ali Akbar; Rahideh, Sanaz; Derakhshani Nezhad, Zahra; Farnia, Parissa; Mirsaeidi, Mehdi

2015-01-01

Nontuberculous mycobacteria (NTM) are a diverse group of bacterial species that are distributed in the environment. Many of these environmental bacteria can cause disease in humans. The identification of NTM in environmental sources is important for both clinical and epidemiological purposes. In this study, the distribution of NTM species from environmental and clinical samples in the Middle East was reviewed. In order to provide an overview of NTM, as well as recent epidemiological trends, a...

Otomastoiditis Caused by Mycobacterium abscessus, the Netherlands

NARCIS (Netherlands)

van Ingen, Jakko; Looijmans, Frank; Mirck, Piet; Dekhuijzen, Richard; Boeree, Martin; van Soolingen, Dick

2010-01-01

To the Editor: Nontuberculous mycobacteria (NTM) are increasingly recognized as human pathogens (1). Otomastoiditis is a rare extrapulmonary NTM disease type first described in 1976; Mycobacterium chelonae-M. abscessus group bacteria, which are rapidly growing NTM, are the most frequent causative

Change in lung function in never-smokers with nontuberculous mycobacterial lung disease: A retrospective study

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Takehiko Kobayashi

2018-05-01

Full Text Available Purpose: Never-smokers account for a large proportion of subjects in general population studies on nontuberculous mycobacteria lung disease (NTM-LD. However, the influence of NTM infection on the lung function of never-smokers has not yet been evaluated. The aim of this study was to determine how NTM-LD impairs the lung function in never-smokers, and whether there are an association between successful NTM-LD treatment in radiologic outcomes and improvement in lung function of never-smokers with NTM-LD or not. Methods: We performed a retrospective study of patients (1 who have never smoked during their lifetime; (2 with at least two respiratory specimens from sputum, one bronchial washing sample, or one lung tissue that were culture positive for the same NTM species; and (3 who underwent at least two pulmonary function tests. We enrolled healthy never-smokers as the control group. Results: In 22 never-smokers with NTM-LD, the median forced expiratory volume in 1 s (FEV1 and forced vital capacity (FVC at baseline was lower than those in 9 healthy never-smokers [1800 vs 2080 ml (p = 0.23 and 2230 vs 2620 ml (p = 0.06], respectively. The median change in FEV1 in never-smokers with NTM-LD was lower than that in healthy never-smokers [−70 vs 20 ml per year (p = 0.07, respectively]. On univariate analysis, baseline %-predicted FEV1 in never-smokers with NTM-LD was associated with changes in FVC (p = 0.026 and FEV1 (p = 0.013. Anti-NTM treatment was administered for at least 1 year in 19 patients (86.4%. The relationship between worsening chest CT findings and rapid progressive decline in both FVC (p = 0.66 and FEV1 (p = 0.23 were not significant. Conclusion: Never-smokers with NTM-LD showed lung function decline. There was no association between successful NTM-LD treatment in radiologic outcomes and improvement in lung function of never-smokers. Keywords: Lung function, Never-smoker, Nontuberculous mycobacterial

Surveillance of Tuberculosis in Taipei: The Influence of Nontuberculous Mycobacteria.

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Chen-Yuan Chiang

Full Text Available Notification of tuberculosis (TB but not nontuberculous mycobacteria (NTM is mandatory in Taiwan. Partly due to the strict regulation on TB notification, several patients infected with NTM were notified as TB cases. Notification of patients infected with NTM as TB cases can trigger public health actions and impose additional burdens on the public health system. We conducted a study to assess the influence of NTM infection on surveillance of TB in Taipei.The study population included all individuals with a positive culture for Mycobacterium who were citizens of Taipei City and notified as TB cases in the calendar years 2007-2010. Of the 4216 notified culture-positive tuberculosis (TB cases, 894 (21.2% were infected with NTM. The average annual reported case rate of infection with NTM was 8.6 (95% confidence interval 7.7-9.4 per 100,000 people. The reported case rate of NTM increased with age in both males and females. The proportion of reported TB cases infected with NTM was significantly higher in females than in males (27.6% vs 17.8%, adjusted OR (adjOR 1.93, 95% confidence interval (CI 1.63-2.28; in smear-positive than in smear-negative (23.1% vs 19.2%, adjOR 1.26, 95% CI 1.08-1.47; and in previously treated cases than in new cases (35.7% vs 19.1%, adjOR 2.30, 95% CI 1.88-2.82. The most frequent species was M. avium complex (32.4%, followed by M. chelonae complex (17.6%, M. fortuitum complex (17.0% and M. kansasii (9.8%. Of the 890 notified NTM cases assessed, 703 (79.0% were treated with anti-TB drugs, and 730 (82.0% were de-notified.The influence of NTM on surveillance of TB in Taipei was substantial. Health authorities should take action to ensure that nucleic acid amplification tests are performed in all smear-positive cases in a timely manner to reduce the misdiagnosis of patients infected with NTM as TB cases.

Surveillance of Tuberculosis in Taipei: The Influence of Nontuberculous Mycobacteria.

Science.gov (United States)

Chiang, Chen-Yuan; Yu, Ming-Chih; Yang, Shiang-Lin; Yen, Muh-Yong; Bai, Kuan-Jen

2015-01-01

Notification of tuberculosis (TB) but not nontuberculous mycobacteria (NTM) is mandatory in Taiwan. Partly due to the strict regulation on TB notification, several patients infected with NTM were notified as TB cases. Notification of patients infected with NTM as TB cases can trigger public health actions and impose additional burdens on the public health system. We conducted a study to assess the influence of NTM infection on surveillance of TB in Taipei. The study population included all individuals with a positive culture for Mycobacterium who were citizens of Taipei City and notified as TB cases in the calendar years 2007-2010. Of the 4216 notified culture-positive tuberculosis (TB) cases, 894 (21.2%) were infected with NTM. The average annual reported case rate of infection with NTM was 8.6 (95% confidence interval 7.7-9.4) per 100,000 people. The reported case rate of NTM increased with age in both males and females. The proportion of reported TB cases infected with NTM was significantly higher in females than in males (27.6% vs 17.8%, adjusted OR (adjOR) 1.93, 95% confidence interval (CI) 1.63-2.28); in smear-positive than in smear-negative (23.1% vs 19.2%, adjOR 1.26, 95% CI 1.08-1.47); and in previously treated cases than in new cases (35.7% vs 19.1%, adjOR 2.30, 95% CI 1.88-2.82). The most frequent species was M. avium complex (32.4%), followed by M. chelonae complex (17.6%), M. fortuitum complex (17.0%) and M. kansasii (9.8%). Of the 890 notified NTM cases assessed, 703 (79.0%) were treated with anti-TB drugs, and 730 (82.0%) were de-notified. The influence of NTM on surveillance of TB in Taipei was substantial. Health authorities should take action to ensure that nucleic acid amplification tests are performed in all smear-positive cases in a timely manner to reduce the misdiagnosis of patients infected with NTM as TB cases.

Identification of non-tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital: a cross-sectional study.

Science.gov (United States)

Ahmed, Imran; Jabeen, Kauser; Hasan, Rumina

2013-10-22

Non-tuberculous mycobacteria (NTM) are opportunistic pathogens in immuno-compromised patients. They are also increasingly recognized as pathogens in immuno-competent individuals. Globally, an increase in NTM isolation is being reported with a varied geographic prevalence of different species around the world. There is lack of data on species distribution of these organisms from Pakistan. Treatment options differ according to the species isolated and its susceptibility profile. Knowledge of local species variation would help targeted therapy. This study was performed to determine frequencies of different NTM species isolated from various clinical specimens submitted at a tertiary care hospital laboratory. NTM isolated from 25955 clinical specimens over a period of two years (2010 to 2011) were included. All NTM were identified using conventional tests. Drug susceptibility testing (DST) was performed by broth microdilution and interpreted according to Clinical and Laboratory Standards Institute's document M24-A2. A total of 104 NTM were included in the study. Of these, 76% (54/71) rapidly growing mycobacteria (RGM) and 57.6% (19/33) slow growing mycobacteria (SGM) could be further identified. Mycobacterium fortuitum (21/54) was the commonest NTM identified among RGM followed by M. mucogenicum (12/54) and M. smegmatis (11/54). Among SGM, M. avium complex (MAC) was the most frequent (14/19). Clinical significance could be assessed in a limited number (52/104) of NTM isolates and MAC appeared to be the commonest significant NTM. Three extra-pulmonary cases were found to be healthcare associated infections. DST results for RGM showed susceptibility to amikacin (100%), clarithromycin (100%, except M. fortuitum where it is not reportable), linezolid (90%) and moxifloxacin (75%). Whereas SGM were susceptible to clarithromycin (100%), linezolid (58.8%) and moxifloxacin (64.7%). This is the first study reporting NTM species and their clinical significance isolated from

Surveillance of Tuberculosis in Taipei: The Influence of Nontuberculous Mycobacteria

OpenAIRE

Chiang, Chen-Yuan; Yu, Ming-Chih; Yang, Shiang-Lin; Yen, Muh-Yong; Bai, Kuan-Jen

2015-01-01

Background Notification of tuberculosis (TB) but not nontuberculous mycobacteria (NTM) is mandatory in Taiwan. Partly due to the strict regulation on TB notification, several patients infected with NTM were notified as TB cases. Notification of patients infected with NTM as TB cases can trigger public health actions and impose additional burdens on the public health system. We conducted a study to assess the influence of NTM infection on surveillance of TB in Taipei. Methodology/Principal Fin...

Comparison of clinico-radiological features of patients with positive cultures of nontuberculous mycobacteria and patients with tuberculosis

International Nuclear Information System (INIS)

Ba-Hammam, Ahmed; Sharif, Yasir; Masood, Mohammad; Isnani, Arthur; Youssef, Ismael; Kambal, Abdelmageed; Shaikh, Shaffi

2005-01-01

To identify the clinico-radiological features of patients with positive cultures for nontuberculous mycobacteria (NTM) and compare those to a sample of patients with tuberculosis (MTB). A laboratory database was used to retrieve all specimens submitted to King Khalid University Hospital, Riyadh, mycobacteriology laboratory for mycobacterial smears and cultures during the period from October 1999-April 2002. Using this database, the original records of the mycobacteriology laboratory and a review of the patient's health records, a standard proforma was completed that included demographic, clinical, radiological and laboratory information on patients included in this study. The patients were divided into 2 groups; the NTM group, which included patients with positive cultures for NTM and the MTB group, which included a sample of patients with documented tuberculosis. During the study period, 286 patients had positive mycobacterial cultures. Seventy patients (24.5%) grew NTM and 216 (75.5%) grew MTB. For patients with MTB, 54 patients were included as per the selection protocol of the study. There was no difference between the 2 groups in all measured demographic variables. The presence of weight loss and fever was significantly more in the MTB group. Radiologically, the presence of hilar adenopathy was more significant among patients with MTB than those with NTM (17% versus 4%, p=0.02). However, bronchiectatic changes were seen significantly more among NTM patients compared to patients with MTB (26% versus 11%, p=0.03). The isolation of NTM in the mycobacteriology laboratory is high. The clinico-radiological features were not sufficiently specific to differentiate patients with NTM from patients with MTB. Local studies are needed to explore NTM disease in various developing countries and identify the NTM species causing infections in non-immunosuppressed patients in each locality. (author)

High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis.

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Elisa López-Varela

Full Text Available Non-tuberculous mycobacteria (NTM can cause disease which can be clinically and radiologically undistinguishable from tuberculosis (TB, posing a diagnostic and therapeutic challenge in high TB settings. We aim to describe the prevalence of NTM isolation and its clinical characteristics in children from rural Mozambique.This study was part of a community TB incidence study in children <3 years of age. Gastric aspirate and induced sputum sampling were performed in all presumptive TB cases and processed for smear testing using fluorochrome staining and LED Microscopy, liquid and solid culture, and molecular identification by GenoType® Mycobacterium CM/AS assays.NTM were isolated in 26.3% (204/775 of children. The most prevalent NTM species was M. intracellulare (N = 128, followed by M. scrofulaceum (N = 35 and M. fortuitum (N = 9. Children with NTM were significantly less symptomatic and less likely to present with an abnormal chest radiograph than those with M. tuberculosis. NTM were present in 21.6% of follow-up samples and 25 children had the same species isolated from ≥2 separate samples. All were considered clinically insignificant and none received specific treatment. Children with NTM isolates had equal all cause mortality and likelihood of TB treatment as those with negative culture although they were less likely to have TB ruled out.NTM isolation is frequent in presumptive TB cases but was not clinically significant in this patient cohort. However, it can contribute to TB misdiagnosis. Further studies are needed to understand the epidemiology and the clinical significance of NTM in children.

Keelatud "Magnus" läheb täismajale / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2008-01-01

Harju maakohtu poolt esinemiskeelu alla pandud K. Kõusaare mängufilmi "Magnus" näitamise kohta Kinoliidu poolt Eesti filmi päevadel. Ka loomeliitude poolt avalikkusele suunatud kirjast selles küsimuses

Natural disasters and nontuberculous mycobacteria: a recipe for increased disease?

Science.gov (United States)

Honda, Jennifer R; Bernhard, Jon N; Chan, Edward D

2015-02-01

Infectious diseases acquired by survivors of large-scale natural disasters complicate the recovery process. During events such as tsunamis, hurricanes, earthquakes, and tornados and well into the recovery period, victims often are exposed to water-soil mixtures that have relocated with indigenous microbes. Because nontuberculous mycobacteria (NTM) are ubiquitous in water and soil, there is potential for increased exposure to these organisms during natural disasters. In this hypothesis-driven commentary, we discuss the rise in NTM lung disease and natural disasters and examine the geographic overlap of NTM infections and disaster frequencies in the United States. Moreover, we show an increased number of positive NTM cultures from Louisiana residents in the years following three of the relatively recent epic hurricanes and posit that such natural disasters may help to drive the increased number of NTM infections. Finally, we advocate for increased environmental studies and surveillance of NTM infections before and after natural disasters.

Natural Disasters and Nontuberculous Mycobacteria

Science.gov (United States)

Bernhard, Jon N.; Chan, Edward D.

2015-01-01

Infectious diseases acquired by survivors of large-scale natural disasters complicate the recovery process. During events such as tsunamis, hurricanes, earthquakes, and tornados and well into the recovery period, victims often are exposed to water-soil mixtures that have relocated with indigenous microbes. Because nontuberculous mycobacteria (NTM) are ubiquitous in water and soil, there is potential for increased exposure to these organisms during natural disasters. In this hypothesis-driven commentary, we discuss the rise in NTM lung disease and natural disasters and examine the geographic overlap of NTM infections and disaster frequencies in the United States. Moreover, we show an increased number of positive NTM cultures from Louisiana residents in the years following three of the relatively recent epic hurricanes and posit that such natural disasters may help to drive the increased number of NTM infections. Finally, we advocate for increased environmental studies and surveillance of NTM infections before and after natural disasters. PMID:25644904

National hospital costs for pulmonary mycobacterial diseases in the US from 2001 to 2012

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Mehdi Mirsaeidi

2015-01-01

Conclusions: The total estimated cost of inpatient care of pulmonary NTM in the US during the study period was almost $1 billion. The cost of NTM management year after year is likewise increasingly significantly at a rate consistent with healthcare inflation. In contrast, pulmonary TB national hospital costs were decreasing during the study period. These trends emphasize the considerable and increasing burden of pulmonary NTM in the US. Given that the majority of patients with pulmonary NTM are never admitted to the hospital, the total economic burden of this disease is tremendously higher than measured in this study. These results emphasize the importance of continued research of pulmonary NTM in order to improve current guidelines in prevention and treatment strategies.

Nontuberculous mycobacteria in Middle East: Current situation and future challenges.

Science.gov (United States)

Velayati, Ali Akbar; Rahideh, Sanaz; Nezhad, Zahra Derakhshani; Farnia, Parissa; Mirsaeidi, Mehdi

2015-03-01

Nontuberculous mycobacteria (NTM) are a diverse group of bacterial species that are distributed in the environment. Many of these environmental bacteria can cause disease in humans. The identification of NTM in environmental sources is important for both clinical and epidemiological purposes. In this study, the distribution of NTM species from environmental and clinical samples in the Middle East was reviewed. In order to provide an overview of NTM, as well as recent epidemiological trends, all studies addressing NTM in the Middle East from 1984 to 2014 were reviewed. A total of 96 articles were found, in which 1751 NTM strains were isolated and 1084 of which were obtained from clinical samples, 619 from environmental samples and 48 were cited by case reports. Mycobacterium fortuitum was the most common rapid growing mycobacteria (RGM) isolated from both clinical (269 out of 447 RGM; 60.1%) and environmental (135 out of 289 RGM; 46.7%) samples. Mycobacterium avium complex (MAC) was the most common slow growing mycobacteria (SGM) isolated from clinical samples (140 out of 637 SGM; 21.9%). An increasing trend in NTM isolation from the Middle East was noted over the last 5years. This review demonstrates the increasing concern regarding NTM disease in the Middle East, emphasizing the need for regional collaboration and coordination in order to respond appropriately. Copyright © 2015 Asian African Society for Mycobacteriology. Published by Elsevier Ltd. All rights reserved.

CT features of pulmonary mycobacterial disease in patients with acquired immunodeficiency syndrome

International Nuclear Information System (INIS)

Zhu Ying; Zhang Zhiyong; Shi Yuxin; Feng Feng

2013-01-01

Objective: To study the CT features of pulmonary non-tuberculous mycobacteria (NTM) disease in patients with acquired immunodeficiency syndrome (AIDS) and explore the different CT appearances between AIDS-NTM and AIDS-TB. Methods: CT findings of pulmonary NTM disease in 27 AIDS patients (NTM group) were retrospectively analyzed and compared with that of tuberculosis in 30 AIDS patients (TB group). The results were statistically analyzed using Fisher's exact test. Results: CT findings of NTM appeared significantly more than that of TB as follows: high-density nodules (n = 18 vs 1, P < 0.01), ground-glass opacities (n = 10 vs 0, P < 0.01), fibrotic band (n = 17 vs 3, P < 0.01), bronchiectasis (9 vs 2, P = 0.012). CT findings of NTM appeared significantly less than that of TB as follows: miliary nodules (0 vs 6, P = 0.016), air space consolidations (n = 2 vs 11, P < 0.01), pleural effusion (n = 1 vs 9, P < 0.01). Conclusion: Nodule and fibrotic band accompanied with bronchiectasis were the main CT manifestations of pulmonary NTM disease in AIDS patients, while air space consolidation accompanied with pleural effusion and miliary nodules were the predominate CT findings of pulmonary tuberculosis in AIDS patients. (authors)

Impact of industrial structure and soil exposure on the regional variations in pulmonary nontuberculous mycobacterial disease prevalence.

Science.gov (United States)

Hamada, Satoshi; Ito, Yutaka; Hirai, Toyohiro; Murase, Kimihiko; Tsuji, Takahiro; Fujita, Kohei; Mio, Tadashi; Maekawa, Koichi; Fujii, Takashi; Ono, Shigeki; Nishimura, Takashi; Hayashi, Akihiko; Komori, Toshiaki; Fujita, Naohisa; Niimi, Akio; Ichiyama, Satoshi; Chin, Kazuo; Mishima, Michiaki

2016-06-01

The prevalence of pulmonary nontuberculous mycobacterial (pNTM) disease, including Mycobacterium avium complex (MAC), varies widely according to geographic region. However, the factors that influence regional variations in pNTM disease prevalence remain unknown. This study was undertaken to examine whether environmental or occupational factors or host traits could influence regional variations in pNTM disease prevalence. We collected laboratory data on pulmonary tuberculosis (pTB) and pNTM from two hospitals in the West Harima area of Japan and five hospitals in Kyoto City, Japan from 2012 to 2013. We estimated microbiological pNTM disease prevalence by multiplying all pTB cases in each area with the ratio of pNTM cases and pTB cases at the survey hospitals in each area. We administered a standardized questionnaire to 52 patients and 120 patients with pulmonary MAC (pMAC) disease at Ako City Hospital and Kyoto University Hospital, respectively. The estimated prevalence of microbiological pNTM disease in the West Harima area (85.4/100,000 population-years) was significantly higher than that observed in Kyoto City (23.6/100,000 population-years; pdisease prevalence. Copyright © 2016 Asian-African Society for Mycobacteriology. Published by Elsevier Ltd. All rights reserved.

Molecular epidemiology of nontuberculous mycobacteria isolates from clinical and environmental sources of a metropolitan city.

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Ali Akbar Velayati

Full Text Available While NTM infection is mainly acquired from environmental exposure, monitoring of environmental niches for NTM is not a routine practice. This study aimed to find the prevalence of environmental NTM in soil and water in four highly populated suburbs of Tehran, Iran.A total of 4014 samples from soil and water resources were collected and studied. Sediments of each treated sample were cultured in Lowenstein-Jensen medium and observed twice per week for growth rate, colony morphology, and pigmentation. Colonies were studied with phenotypic tests. Molecular analysis was performed on single colonies derived from subculture of original isolates. Environmental samples were compared with 34 NTM isolates from patients who were residents of the study locations.Out of 4014 samples, mycobacteria were isolated from 862 (21.4% specimens; 536 (62.1% belonged to slow growing mycobacteria (SGM and 326 (37.8% were rapid growing mycobacteria (RGM. The five most frequent NTM were M. farcinogens (105/862; 12.1%, M. fortuitum (72/862; 8.3%, M. senegalense (58/862; 6.7%, M. kansasii (54/862; 6.2%, and M. simiae (46/862; 5.3%. In total, 62.5% (539/862 of mycobacterial positive samples were isolated from water and only 37.4% (323/862 of them were isolated from soil samples (P<0.05. Out of 5314 positive clinical samples for mycobacteria, 175 (3.2% isolates were NTM. The trend of NTM isolates increased from 1.2% (13 out of 1078 in 2004 to 3.8% (39 out of 1005 in 2014 (P = 0.0001. The major clinical isolates were M. simiae (51; 29.1%, M. kansasii (26; 14.8%, M. chelonae (28; 16%, and M. fortuitum (13; 7.4%.Comparing the distribution pattern of environmental NTM isolates with clinical isolates suggests a possible transmission link, but this does not apply to all environmental NTM species. Our study confirms an increasing trend of NTM isolation from clinical samples that needs further investigation.

Sõidud teiselt poolt / Oudekki Loone

Index Scriptorium Estoniae

Loone, Oudekki, 1979-

2004-01-01

Mängufilm "Täna öösel me ei maga" : stsenaristid Kristian Taska, Jaan Tätte, Mihkel Ulman : režissöör Ilmar Taska : produtsent Kristian Taska : Taska Productions 2004. Eelkõige analüüsitakse operaator Istvan Borbase tööd

Towards self-consistent plasma modelisation in presence of neoclassical tearing mode and sawteeth: effects on transport coefficients

Science.gov (United States)

Basiuk, V.; Huynh, P.; Merle, A.; Nowak, S.; Sauter, O.; Contributors, JET; the EUROfusion-IM Team

2017-12-01

The neoclassical tearing modes (NTM) increase the effective heat and particle radial transport inside the plasma, leading to a flattening of the electron and ion temperature and density profiles at a given location depending on the safety factor q rational surface (Hegna and Callen 1997 Phys. Plasmas 4 2940). In burning plasma such as in ITER, this NTM-induced increased transport could reduce significantly the fusion performance and even lead to a disruption. Validating models describing the NTM-induced transport in present experiment is thus important to help quantifying this effect on future devices. In this work, we apply an NTM model to an integrated simulation of current, heat and particle transport on JET discharges using the European transport simulator. In this model, the heat and particle radial transport coefficients are modified by a Gaussian function locally centered at the NTM position and characterized by a full width proportional to the island size through a constant parameter adapted to obtain the best simulations of experimental profiles. In the simulation, the NTM model is turned on at the same time as the mode is triggered in the experiment. The island evolution is itself determined by the modified Rutherford equation, using self-consistent plasma parameters determined by the transport evolution. The achieved simulation reproduces the experimental measurements within the error bars, before and during the NTM. A small discrepancy is observed on the radial location of the island due to a shift of the position of the computed q = 3/2 surface compared to the experimental one. To explain such small shift (up to about 12% with respect to the position observed from the experimental electron temperature profiles), sensitivity studies of the NTM location as a function of the initialization parameters are presented. First results validate both the transport model and the transport modification calculated by the NTM model.

Molecular epidemiology of nontuberculous mycobacteria isolates from clinical and environmental sources of a metropolitan city.

Science.gov (United States)

Velayati, Ali Akbar; Farnia, Parissa; Mozafari, Mohadese; Malekshahian, Donya; Seif, Shima; Rahideh, Snaz; Mirsaeidi, Mehdi

2014-01-01

While NTM infection is mainly acquired from environmental exposure, monitoring of environmental niches for NTM is not a routine practice. This study aimed to find the prevalence of environmental NTM in soil and water in four highly populated suburbs of Tehran, Iran. A total of 4014 samples from soil and water resources were collected and studied. Sediments of each treated sample were cultured in Lowenstein-Jensen medium and observed twice per week for growth rate, colony morphology, and pigmentation. Colonies were studied with phenotypic tests. Molecular analysis was performed on single colonies derived from subculture of original isolates. Environmental samples were compared with 34 NTM isolates from patients who were residents of the study locations. Out of 4014 samples, mycobacteria were isolated from 862 (21.4%) specimens; 536 (62.1%) belonged to slow growing mycobacteria (SGM) and 326 (37.8%) were rapid growing mycobacteria (RGM). The five most frequent NTM were M. farcinogens (105/862; 12.1%), M. fortuitum (72/862; 8.3%), M. senegalense (58/862; 6.7%), M. kansasii (54/862; 6.2%), and M. simiae (46/862; 5.3%). In total, 62.5% (539/862) of mycobacterial positive samples were isolated from water and only 37.4% (323/862) of them were isolated from soil samples (Pdistribution pattern of environmental NTM isolates with clinical isolates suggests a possible transmission link, but this does not apply to all environmental NTM species. Our study confirms an increasing trend of NTM isolation from clinical samples that needs further investigation.

Control of neoclassical tearing mode by electron cyclotron current drive and non-resonant helical field application in ITER

International Nuclear Information System (INIS)

Taniguchi, Satoshi; Yamazaki, Kozo; Oishi, Tetsutarou; Arimoto, Hideki; Shoji, Tatsuo

2010-01-01

On tokamak plasmas like ITER, it is necessary to stabilize neoclassical tearing mode (NTM) because the NTM reduces plasma temperature and fusion power output. For the analysis of stabilizing NTM in fusion plasmas, the electron cyclotron current drive (ECCD) and the non-resonant external helical field (NRHF) application are simulated using the 1.5-dimensional equilibrium/transport simulation code (TOTAL code). The 3/2 NTM is stabilized by only external helical field, but the 2/1 mode is not stabilized by only external helical field in the present model. The stabilization time becomes shorter by the combination of ECCD and NRHF than that by ECCD alone. (author)

Non-tuberculous mycobacteria I: one year clinical isolates identification in Tertiary Hospital Aids Reference Center, Rio de Janeiro, Brazil, in pre highly active antiretroviral therapy era

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Ferreira Rosa Maria Carvalho

2002-01-01

Full Text Available The aim of this study was to determine the prevalence of non-tuberculous mycobacteria (NTM isolates at University Hospital, Reference Center for Aids in Rio de Janeiro, Brazil, during one year. We used standard biochemical tests for species identification and IS1245 PCR amplification was applied as a Mycobacterium avium specific identification marker. Four hundred and four specimens from 233 patients yielded acid-fast bacilli growth. M. tuberculosis was identified in 85% of the patients and NTM in 15%. NTM disseminated infection was a common event correlated with human immunodeficiency virus (HIV infected patients and only in HIV negative patients the source of NTM was non sterile site. M. avium complex (MAC was biochemically identified in 57.8% (49/83 of NTM isolates, most of them from sterile sites (75.5%, and in 94% (46/49 the IS 1245 marker specific for M. avium was present. Twenty NTM strains showed a MAC biochemical pattern with the exception of a urease-positive (99% of MAC are urease-negative, however IS1245 was detected in 96% of the strains leading to their identification as M. avium. In this group differences in NTM source was not significant. The second most frequently isolated NTM was identified as M. scrofulaceum (7.2%, followed by M. terrae (3.6%, M. gordonae (2.4%, M. chelonae (1.2%, M. fortuitum (1.2% and one strain which could not be identified. All were IS1245 negative except for one strain identified as M. scrofulaceum. It is interesting to note that non-sterile sites were the major source of these isolates (92.8%. Our finding indicated that M. avium is still the major atypical species among in the MAC isolates recovered from Brazilian Aids patients without highty active antiretroviral therapy schema. Some discrepancies were seen between the identification methods and further investigations must be done to better characterize NTM isolates using other phenotypic and genotypic methods.

Nontuberculous mycobacteria in respiratory samples from patients with pulmonary tuberculosis in the state of Rondonia, Brazil

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Cleoni Alves Mendes de Lima

2013-06-01

Full Text Available The main cause of pulmonary tuberculosis (TB is infection with Mycobacterium tuberculosis (MTB. We aimed to evaluate the contribution of nontuberculous mycobacteria (NTM to pulmonary disease in patients from the state of Rondônia using respiratory samples and epidemiological data from TB cases. Mycobacterium isolates were identified using a combination of conventional tests, polymerase chain reaction-based restriction enzyme analysis of hsp65 gene and hsp65 gene sequencing. Among the 1,812 cases suspected of having pulmonary TB, 444 yielded bacterial cultures, including 369 cases positive for MTB and 75 cases positive for NTM. Within the latter group, 14 species were identified as Mycobacterium abscessus, Mycobacterium avium, Mycobacterium fortuitum, Mycobacterium intracellulare, Mycobacterium gilvum, Mycobacterium gordonae, Mycobacterium asiaticum, Mycobacterium tusciae, Mycobacterium porcinum, Mycobacterium novocastrense, Mycobacterium simiae, Mycobacterium szulgai, Mycobacterium phlei and Mycobacterium holsaticum and 13 isolates could not be identified at the species level. The majority of NTM cases were observed in Porto Velho and the relative frequency of NTM compared with MTB was highest in Ji-Paraná. In approximately half of the TB subjects with NTM, a second sample containing NTM was obtained, confirming this as the disease-causing agent. The most frequently observed NTM species were M. abscessus and M. avium and because the former species is resistant to many antibiotics and displays unsatisfactory cure rates, the implementation of rapid identification of mycobacterium species is of considerable importance.

Non-tuberculous mycobacterial lung disease: diagnosis based on computed tomography of the chest

Energy Technology Data Exchange (ETDEWEB)

Kwak, Nakwon; Han, Sung Koo; Yim, Jae-Joon [Seoul National University College of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul (Korea, Republic of); Lee, Chang Hyun; Lee, Hyun-Ju [Seoul National University College of Medicine, Department of Radiology, and Institute of Radiation Medicine, Seoul (Korea, Republic of); Kang, Young Ae [Yonsei University College of Medicine, Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Seoul (Korea, Republic of); Lee, Jae Ho [Seoul National University Bundang Hospital, Department of Internal Medicine, Seongnam, Gyeonggi-do (Korea, Republic of)

2016-12-15

To elucidate the accuracy and inter-observer agreement of non-tuberculous mycobacterial lung disease (NTM-LD) diagnosis based on chest CT findings. Two chest radiologists and two pulmonologists interpreted chest CTs of 66 patients with NTM-LD, 33 with pulmonary tuberculosis and 33 with non-cystic fibrosis bronchiectasis. These observers selected one of these diagnoses for each case without knowing any clinical information except age and sex. Sensitivity and specificity were calculated according to degree of observer confidence. Inter-observer agreement was assessed using Fleiss' κ values. Multiple logistic regression was performed to elucidate which radiological features led to the correct diagnosis. The sensitivity of NTM-LD diagnosis was 56.4 % (95 % CI 47.9-64.7) and specificity 80.3 % (73.1-86.0). The specificity of NTM-LD diagnosis increased with confidence: 44.4 % (20.5-71.3) for possible, 77.4 % (67.4-85.0) for probable, 95.2 % (87.2-98.2) for definite (P < 0.001) diagnoses. Inter-observer agreement for NTM-LD diagnosis was moderate (κ = 0.453). Tree-in-bud pattern (adjusted odds ratio [aOR] 6.24, P < 0.001), consolidation (aOR 1.92, P = 0.036) and atelectasis (aOR 3.73, P < 0.001) were associated with correct NTM-LD diagnoses, whereas presence of pleural effusion (aOR 0.05, P < 0.001) led to false diagnoses. NTM-LD diagnosis based on chest CT findings is specific but not sensitive. (orig.)

Improved localisation of neoclassical tearing modes by combining multiple diagnostic estimates

Science.gov (United States)

Rapson, C. J.; Fischer, R.; Giannone, L.; Maraschek, M.; Reich, M.; Treutterer, W.; The ASDEX Upgrade Team

2017-07-01

Neoclassical tearing modes (NTMs) strongly degrade confinement in tokamaks, and are a leading cause of disruptions. They can be stabilised by targeted electron cyclotron current drive (ECCD), however the effectiveness of ECCD depends strongly on the accuracy or misalignment between ECCD and the NTM. The first step to ensure minimal misalignment is a good estimate of the NTM location. In previous NTM control experiments, three methods have been used independently to estimate the NTM location: the magnetic equilibrium, correlation between magnetic and spatially-resolved temperature fluctuations, and the amplitude response of the NTM to nearby ECCD. This submission describes an algorithm which has been designed to fuse these three estimates into one, taking into account many of the characteristics of each diagnostic. Although the method diverges from standard data fusion methods, results from simulation and experiment confirm that the algorithm achieves its stated goal of providing an estimate that is more reliable and accurate than any of the individual estimates.

Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria - experiences from the Danish Cystic Fibrosis cohort study

DEFF Research Database (Denmark)

Qvist, Tavs; Johansen, Isik S.; Pressler, Tania

2014-01-01

had active TB. The TB-LAM test had an overall positive rate of 2.5% applying a grade 2 cut-point as positivity threshold, increasing to 10.6% (21/198) if a grade 1 cut-point was applied. Among patients with NTM infection 2/23 (8.7%) had a positive LAM test result at the grade 2 cut-point and 9/23 (39.......1%) at the grade 1 cut -point. Test specificity for NTM diagnosis was 98.3% and 93.1 for grade 2 and 1 cut-point respectively. Conclusions: This is the first study to assess urine LAM detection in patients with confirmed NTM infection. The study demonstrated low cross-reactivity due to NTM infection when using...... the recommended grade 2 cut-point as positivity threshold. This is reassuring in regards to interpretation of the LAM test for TB diagnosis in a TB prevalent setting. The test was not found suitable for NTM detection among patients with CF....

The first Saudi Arabian national inventory study revealed the upcoming challenges of highly diverse non-tuberculous mycobacterial diseases.

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Bright Varghese

2018-05-01

Full Text Available Incidences of nontuberculous mycobacteria (NTM causing pulmonary and extrapulmonary diseases are reportedly increasing globally and the current epidemiologic situation in Saudi Arabia remains unclear. To study such trend, we carried out a nationwide systematic epidemiological study focusing on NTM diseases for the first time in the country.A nationwide collection of NTM isolates with clinical and demographical data was conducted for a period of 24 months. Primary species identification was carried out by line probe assays followed by sequencing of 16S rRNA, 16S-23S ITS region, rpoB and hsp65 genes. The laboratory findings were comprehensively analysed against demographical and clinical data. A total of 527 isolates were enrolled with a higher proportion of Saudi citizens (76.5%, elderly (>60 years patients (34.2%, and male gender (65.3% respectively. Overall, 75.1% isolates were pulmonary origin with a proven clinical significance of 44.7%. In total, 34 NTM species including 17 rare species were identified, in addition to 8 'undefined' isolates. M.simiae (22.6%, M.fortuitum (18.1% and M.abscessus (17.8% were predominant species. Interestingly, 27 new cases of clinically relevant M.riyadhense were also noticed (Primary data on emergence of rare NTM species and M.riyadhense has been recently reported. Results showed, rare clinical events such as mycobacteremia, cecum abscess, peritonitis and ascites caused by M.wolinskyi, M.holsaticum, M.duvalii and M.monacence respectively. Diabetes mellitus (P value-0.04 and previous history of tuberculosis (P value- 0.001 were identified as independent risk factors associated with NTM diseases.NTM disease spectrum and pathogen diversity is an emerging challenge to any nation, including Saudi Arabia. Therefore, more priorities will be given to NTM's with an immediate initiative to develop diagnostic infrastructures and disease management plans.

Increase in nontuberculous mycobacteria isolated in Shanghai, China: results from a population-based study.

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Jie Wu

Full Text Available BACKGROUND: In China, the prevalence of nontuberculous mycobacteria (NTM in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB is largely unknown. METHODS: We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimens from patients suspected of having TB. Drug-susceptibility testing was performed on NTM isolates using the proportion method. We also determined the independent risk factors associated with infection with NTM compared with infection with Mycobacterium tuberculosis. RESULTS: The overall rate of NTM isolated from mycobacterial culture-positive patients was 5.9% in this population, with a significantly increasing trend from 3.0% in 2008 to 8.5% in 2012 (P for trend <0.001. The organism most frequently identified was M. kansasii (45.0%, followed by M. intracellulare (20.8% and M. chelonae/abscessus (14.9%. The overall proportion of isolates resistant to the four first-line anti-TB agents were 64.6% for isoniazid, 77.6% for streptomycin, 63.3% for rifampicin and 75.1% for ethambutol. The risk factors most often associated with NTM infection were older age (P for trend <0.001, being a resident of Shanghai (adjusted odds ratio [aOR], 1.48; 95% CI, 1.10-2.00, having been treated for tuberculosis (aOR, 1.64; 95% CI, 1.18-2.29, having a cavity on chest X-ray (aOR, 1.51; 95% CI, 1.16-1.96, and being sputum smear-negative (aOR, 1.59; 95% CI, 1.16-2.18. CONCLUSIONS: The prevalence of NTM isolated in Shanghai increased between 2008 and 2012, thus clinicians should consider NTM as a possible cause of TB-like disease. Accurate species identification is imperative so that proper treatment can be administered for diseases caused by the diversity of NTM species.

Role of genotype® mycobacterium common mycobacteria/additional species assay for rapid differentiation between Mycobacterium tuberculosis complex and different species of non-tuberculous mycobacteria

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Amresh Kumar Singh

2013-01-01

Full Text Available Background: Mycobacterium tuberculosis complex (MTBC and non-tuberculous mycobacteria (NTM may or may not have same clinical presentations, but the treatment regimens are always different. Laboratory differentiation between MTBC and NTM by routine methods are time consuming and cumbersome to perform. We have evaluated the role of GenoType® Mycobacterium common mycobacteria/additional species (CM/AS assay for differentiation between MTBC and different species of NTM in clinical isolates from tuberculosis (TB cases. Materials and Methods: A total of 1080 clinical specimens were collected from January 2010 to June 2012. Diagnosis was performed by Ziehl-Neelsen staining followed by culture in BacT/ALERT 3D system (bioMerieux, France. A total of 219 culture positive clinical isolates (BacT/ALERT® MP cultures were selected for differentiation by p-nitrobenzoic acid (PNB sensitivity test as and BIO-LINE SD Ag MPT64 TB test considering as the gold standard test. Final identification and differentiation between MTBC and different species of NTM were further confirmed by GenoType® Mycobacterium CM/AS assay (Hain Lifescience, Nehren, Germany. Results: Out of 219 BacT/ALERT® MP culture positive isolates tested by PNB as 153 MTBC (69.9% and by GenoType® Mycobacterium CM/AS assay as 159 (72.6% MTBC and remaining 60 (27.4% were considered as NTM species. The GenoType® Mycobacterium CM/AS assay was proved 99.3% sensitive and 98.3% specific for rapid differentiation of MTBC and NTM. The most common NTM species were; Mycobacterium fortuitum 20 (33.3% among rapid growing mycobacteria and Mycobacterium intracellulare 11 (18.3% among slow growing mycobacteria. Conclusion: The GenoType® Mycobacterium assay makes rapid and accurate identification of NTM species as compared with different phenotypic and molecular diagnostic tool and helps in management of infections caused by different mycobacteria.

Using Syndromic Surveillance to Investigate Tattoo-Related Skin Infections in New York City.

Science.gov (United States)

Kotzen, Mollie; Sell, Jessica; Mathes, Robert W; Dentinger, Catherine; Lee, Lillian; Schiff, Corinne; Weiss, Don

2015-01-01

In response to two isolated cases of Mycobacterium chelonae infections in tattoo recipients where tap water was used to dilute ink, the New York City (NYC) Department of Health and Mental Hygiene conducted an investigation using Emergency Department (ED) syndromic surveillance to assess whether an outbreak was occuring. ED visits with chief complaints containing the key word "tattoo" from November 1, 2012 to March 18, 2013 were selected for study. NYC laboratories were also contacted and asked to report skin or soft tissue cultures in tattoo recipients that were positive for non-tuberculosis mycobacterial infection (NTM). Thirty-one TREDV were identified and 14 (45%) were interviewed to determine if a NTM was the cause for the visit. One ED visit met the case definition and was referred to a dermatologist. This individual was negative for NTM. No tattoo-associated NTM cases were reported by NYC laboratories. ED syndromic surveillance was utilized to investigate a non-reportable condition for which no other data source existed. The results were reassuring that an outbreak of NTM in tattoo recipients was not occurring. In response to concerns about potential NTM infections, the department sent a letter to all licensed tattoo artists advising them not to dilute tattoo ink with tap water.

Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study

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Clare L. van Halsema

2015-01-01

Full Text Available Background. The clinical relevance of nontuberculous mycobacteria (NTM, detected by liquid more than solid culture in sputum specimens from a South African mining workforce, is uncertain. We aimed to describe the current spectrum and relevance of NTM in this population. Methods. An observational study including individuals with sputum NTM isolates, recruited at workforce tuberculosis screening and routine clinics. Symptom questionnaires were administered at the time of sputum collection and clinical records and chest radiographs reviewed retrospectively. Results. Of 232 individuals included (228 (98% male, median age 44 years, M. gordonae (60 individuals, M. kansasii (50, and M. avium complex (MAC: 38 were the commonest species. Of 38 MAC isolates, only 2 (5.3% were from smear-positive sputum specimens and 30/38 grew in liquid but not solid culture. MAC was especially prevalent among symptomatic, HIV-positive individuals. HIV prevalence was high: 57/74 (77% among those tested. No differences were found in probability of death or medical separation by NTM species. Conclusions. M. gordonae, M. kansasii, and MAC were the commonest NTM among miners with suspected tuberculosis, with most MAC from smear-negative specimens in liquid culture only. HIV testing and identification of key pathogenic NTM in this setting are essential to ensure optimal treatment.

Using Syndromic Surveillance to Investigate Tattoo-Related Skin Infections in New York City.

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Mollie Kotzen

Full Text Available In response to two isolated cases of Mycobacterium chelonae infections in tattoo recipients where tap water was used to dilute ink, the New York City (NYC Department of Health and Mental Hygiene conducted an investigation using Emergency Department (ED syndromic surveillance to assess whether an outbreak was occuring. ED visits with chief complaints containing the key word "tattoo" from November 1, 2012 to March 18, 2013 were selected for study. NYC laboratories were also contacted and asked to report skin or soft tissue cultures in tattoo recipients that were positive for non-tuberculosis mycobacterial infection (NTM. Thirty-one TREDV were identified and 14 (45% were interviewed to determine if a NTM was the cause for the visit. One ED visit met the case definition and was referred to a dermatologist. This individual was negative for NTM. No tattoo-associated NTM cases were reported by NYC laboratories. ED syndromic surveillance was utilized to investigate a non-reportable condition for which no other data source existed. The results were reassuring that an outbreak of NTM in tattoo recipients was not occurring. In response to concerns about potential NTM infections, the department sent a letter to all licensed tattoo artists advising them not to dilute tattoo ink with tap water.

Effect of chlorine on Mycobacterium gordonae and Mycobacterium chubuense in planktonic and Biofilm State

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Alejandra Soledad Oriani

2018-01-01

Full Text Available Background: There is evidence that drinking water could be a source of infections with pathogenic nontuberculous mycobacteria (NTM potentially risky to human health. The aim was to investigate the resistance of two NTM isolated from drinking water, Mycobacterium gordonae and Mycobacterium chubuense, at different concentrations of chlorine (as sodium hypochlorite, used in drinking water sanitation. Methods: The NTM were grown in suspension and in biofilms and were challenged with biocide for 10 and 60 min. Results: To obtain 7-log reduction from the initial population of M. chubuense, in the planktonic state, there were necessary 20 ppm of chorine and 60 min of exposure. The same effect was achieved in M. gordonae with 10 ppm for the same period. The maximum reduction of both NTM in biofilm was 3-log reduction and was achieved using 30 ppm for 60 min. The chlorine susceptibility of cells in biofilms was significantly lower than that of planktonic cells. The results highlight the resistance of both NTM to the concentrations used in routine water sanitation (0.2 ppm according to Argentine Food Code. Differences in chlorine resistance found between the two NTM in planktonic growth decrease when they are grown in biofilm. Conclusion: This suggests that current water disinfection procedures do not always achieve effective control of NTM in the public supply system, with the consequent health risk to susceptible population, and the need to take into account biofilms, because of their deep consequences in the way to analyze the survival of prokaryotic cells in different environments.

Microbiological Features and Clinical Relevance of New Species of the Genus Mycobacterium

Science.gov (United States)

2014-01-01

SUMMARY Nontuberculous mycobacteria (NTM) are present in the environment, mainly in water, and are occasionally responsible for opportunistic infections in humans. Despite the fact that NTM are characterized by a moderate pathogenicity, the diseases caused by NTM at various body sites are increasing on a worldwide level. Among over 150 officially recognized NTM species, only two or three dozen are familiar to clinicians, and even to most microbiologists. In this paper, approximately 50 new species described in the last 8 years are reviewed, and their role in human infections is assessed on the basis of reported clinical cases. The small number of reports concerning most of the “new” mycobacterial species is responsible for the widespread conviction that they are very rare. Their role is actually largely underestimated, mainly because they often remain unrecognized and misidentified. Aiming to minimize such bias, emphasis has been placed on more common identification pitfalls. Together with new NTM, new members of the Mycobacterium tuberculosis complex described in the last few years are also an object of the present review. PMID:25278573

Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: comparisons of thin-section CT findings

International Nuclear Information System (INIS)

Chung, Myung Jin; Lee, Kyung Soo; Kim, Tae Sung; Kim, Sung Mok; Koh, Won-Jung; Kwon, O Jung; Kang, Eun Young; Kim, Seonwoo

2006-01-01

The aim of this work was to compare thin-section CT (TSCT) findings of drug-sensitive (DS) tuberculosis (TB), multidrug-resistant (MDR) TB, and nontuberculous mycobacterial (NTM) pulmonary disease in nonAIDS adults. During 2003, 216 (113 DS TB, 35 MDR TB, and 68 NTM) patients with smear-positive sputum for acid-fast bacilli (AFB), and who were subsequently confirmed to have mycobacterial pulmonary disease, underwent thoracic TSCT. The frequency of lung lesion patterns on TSCT and patients' demographic data were compared. The commonest TSCT findings were tree-in-bud opacities and nodules. On a per-person basis, significant differences were found in the frequency of multiple cavities and bronchiectasis (P<0.001, chi-square test and multiple logistic regression analysis). Multiple cavities were more frequent in MDR TB than in the other two groups and extensive bronchiectasis in NTM disease (multiple logistic regression analysis). Patients with MDR TB were younger than those with DS TB or NTM disease (P<0.001, multiple logistic regression analysis). Previous tuberculosis treatment history was significantly more frequent in patients with MDR TB or NTM disease (P<0.001, chi-square test and multiple logistic regression analysis). In patients with positive sputum AFB, multiple cavities, young age, and previous tuberculosis treatment history imply MDR TB, whereas extensive bronchiectasis, old age, and previous tuberculosis treatment history NTM disease. (orig.)

The frequency and treatment of pneumothorax associated with pulmonary nontuberculous mycobacterial infection.

Science.gov (United States)

Ikeda, Masaki; Takahashi, Koji; Komatsu, Teruya; Tanaka, Toru; Kato, Tatsuo; Fujinaga, Takuji

2017-02-01

Characteristics of pneumothorax associated with nontuberculous mycobacterium (NTM) infection are rarely reported, especially in terms of surgical treatments. Our objectives were to show the tendency and clinical courses of pneumothorax due to NTM and discuss the way of therapy in our hospital. We retrospectively analyzed 557 patients with NTM infection over a period of 5 years at the Nagara Medical Center. A total of 12 out of the 557 patients (2.2%) suffered from pneumothorax caused by NTM infection without other pulmonary diseases. The diagnosis of all NTM cases was mycobacterium avium complex. Of these 12 patients, three required observation only (25%), five required drainage only (42%), and four required surgery after drainage (33%). The four surgically treated patients suffered from empyema as well as pneumothorax. They were in worse nutritional condition than non-surgically treated patients. For the patients requiring surgery, we selected reasonable surgical methods; we sutured the fistula of lung in all cases and covered it with muscle or omentum or polyglycolic acid sheets without a case in which endobronchial embolization was performed in advance before surgery. Finally, all pneumothorax healed. Thereafter, three of these four patients took unfavorable courses: progressing malnutrition, complications worsening or contralateral pneumothorax. We should select an appropriate treatment including surgery against NTM-associated pneumothorax without losing an opportunity because of its intractability and exhausting effect.

Prevalence of Nontuberculous Mycobacteria among Extrapulmonary Tuberculosis Cases in Tertiary Care Centers in Northern India

Directory of Open Access Journals (Sweden)

A. K. Maurya

2015-01-01

Full Text Available The reports of nontuberculous mycobacteria (NTM associated with extrapulmonary diseases are increasing in tertiary care hospitals. Despite a significant increase in knowledge about NTM infections, they still represent a diagnostic and therapeutic challenge. The aim of this study is to know the prevalence of NTN among extrapulmonary tuberculosis cases in tertiary care centers in Northern India. A total of 227 culture positive isolates from 756 cases were tested for niacin production and catalase assay. BIO-LINE SD Ag MPT64 TB test and final identification and differentiation between MTBC and different species of NTM were further confirmed by GenoType Mycobacterium CM/AS assay. 71 cases (9.3% were positive for AFB by ZN staining and 227 cases (30.1% were positive for mycobacteria by culture. Niacin production and catalase activity were negative in 62/227 (27.4% strains and after using a panel of different biochemicals and final confirmation by GenoType Mycobacterium CM assay. Out of 227 cultures tested, 165 (72.6% strains were confirmed as M. tuberculosis complex, and 62 (27.4% were confirmed as NTM. The most common NTM species identified were M. fortuitum 17 (27.5% and M. intracellulare 13 (20.9%. The rapid identification of NTM species may help in targeted therapy and management of the diseases.

Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: comparisons of thin-section CT findings

Energy Technology Data Exchange (ETDEWEB)

Chung, Myung Jin; Lee, Kyung Soo; Kim, Tae Sung; Kim, Sung Mok [Sungkyunkwan University School of Medicine, Department of Radiology and Center for Imaging Science, Samsung Medical Center, Seoul (Korea); Koh, Won-Jung; Kwon, O Jung [Sungkyunkwan University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Seoul (Korea); Kang, Eun Young [Korea University Guro Hospital, Department of Diagnostic Radiology, Korea University College of Medicine, Seoul (Korea); Kim, Seonwoo [Sungkyunkwan University School of Medicine, Biostatistics Unit of the Samsung Biomedical Research Institute, Samsung Medical Center, Seoul (Korea)

2006-09-15

The aim of this work was to compare thin-section CT (TSCT) findings of drug-sensitive (DS) tuberculosis (TB), multidrug-resistant (MDR) TB, and nontuberculous mycobacterial (NTM) pulmonary disease in nonAIDS adults. During 2003, 216 (113 DS TB, 35 MDR TB, and 68 NTM) patients with smear-positive sputum for acid-fast bacilli (AFB), and who were subsequently confirmed to have mycobacterial pulmonary disease, underwent thoracic TSCT. The frequency of lung lesion patterns on TSCT and patients' demographic data were compared. The commonest TSCT findings were tree-in-bud opacities and nodules. On a per-person basis, significant differences were found in the frequency of multiple cavities and bronchiectasis (P<0.001, chi-square test and multiple logistic regression analysis). Multiple cavities were more frequent in MDR TB than in the other two groups and extensive bronchiectasis in NTM disease (multiple logistic regression analysis). Patients with MDR TB were younger than those with DS TB or NTM disease (P<0.001, multiple logistic regression analysis). Previous tuberculosis treatment history was significantly more frequent in patients with MDR TB or NTM disease (P<0.001, chi-square test and multiple logistic regression analysis). In patients with positive sputum AFB, multiple cavities, young age, and previous tuberculosis treatment history imply MDR TB, whereas extensive bronchiectasis, old age, and previous tuberculosis treatment history NTM disease. (orig.)

[Study on pulmonary lesions in which nontuberculous mycobacteria were detected by percutaneous aspiration--a proposal to add "culture positivity of percutaneous aspiration material" to the bacteriological diagnostic criteria of pulmonary nontuberculous mycobacterial diseases].

Science.gov (United States)

Nakahara, Yasuharu; Mochizuki, Yoshiro; Kawamura, Tetsuji; Sasaki, Shin; Morimoto, Akie; Mizumori, Yasuyuki; Tsukamoto, Hiroaki; Watanabe, Etsuko; Yokoyama, Toshihide

2013-03-01

Culture positivity of percutaneous aspiration material" is not included in the current bacteriological criteria for diagnosis of pulmonary nontuberculous mycobacterial (NTM) diseases, which were published by the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) in 2007 or those released by the Japanese Society for Tuberculosis in 2008. However, percutaneous aspiration is a reliable technique for the detection of causative microorganisms isolated from the focus of infection. We discuss the benefits of including positive culture of percutaneous aspiration material in the bacteriological diagnostic criteria of pulmonary NTM diseases. We reviewed the radiological images and clinical courses of pulmonary diseases in which NTM cultures were obtained from percutaneously aspirated materials at our hospital from 1991 to 2011. Aspiration was carried out under local anesthesia, usually with fluoroscopic guidance. After percutaneous insertion of a 22-gauge needle attached to a 20-mL syringe containing about 3 mL of saline, the lesion specimen was withdrawn together with the saline. After the needle was pulled out, the aspirated material and saline were transferred to test tubes for cytological and microbiological examinations. In patients with thin-walled cavitary lesions, saline was injected into the cavity and then aspirated. Percutaneous aspiration was performed in 2,742 patients and NTM disease was detected in 51 patients. Of these 51 patients, 12 had solitary nodular lesions, and in many of these patients, no NTM bacilli could be detected in the sputa or bronchial washing specimens. Mycobacterium avium was identified in 10 of the 12 cases. Four of these 10 patients were followed up after their diagnosis without any treatment: 3 showed spontaneous reduction in lesion size, while 1 patient's condition remained unchanged. Four of the remaining 6 cases were treated with anti-NTM medications, and lesion size reduced in 2 cases, while no change or

Predictive factors for a one-year improvement in nontuberculous mycobacterial pulmonary disease: An 11-year retrospective and multicenter study.

Science.gov (United States)

Cadelis, Gilbert; Ducrot, Rodolphe; Bourdin, Arnaud; Rastogi, Nalin

2017-08-01

Nontuberculous mycobacterial pulmonary disease (NTM-PD) has become an emerging infectious disease and is responsible for more deaths than tuberculosis in industrialized countries. NTM-PD mortality remains high in some series reportedly ranging from 25% to 40% at five years and often due to unfavorable evolution of NTM-PD despite established treatment. The purpose of our study was to search for early factors that could predict the favorable or unfavorable evolution of NTM-PD at the first year of treatment. In this retrospective and multicenter study, we selected 119 patients based on clinical, radiological and microbiological data from 2002 to 2012 from three French university hospitals (Guadeloupe, Martinique, Montpellier) with definite (meeting the criteria of the American Thoracic Society and the Infectious Disease Society of America in 2007; ATS/IDSA) or probable (one positive sputum culture) NTM-PD. We compared two patient groups: those who improved at one year (clinical symptoms, radiological lesions and microbiology data) and those who did not improve at one year. The data were analyzed for all patients as well as for subgroups by gender, HIV-positive patients, and Mycobacterium avium complex (MAC) infection. The average patient age was 50 years ± 19.4; 58% had respiratory comorbidities, 24% were HIV positive and 19% had cystic fibrosis. Coughing concerned 66% of patients and bronchiectasis concerned 45%. The most frequently isolated NTM were MAC (46%). 57% (n = 68) of patients met the ATS criteria and improved status concerned 38.6% (n = 46). The improvement factors at one year of NTM-PD were associated with the duration of ethambutol treatment: (Odds ratio adjusted [ORa]: 2.24, 95% Confidence interval [CI]; 2.11-3.41), HIV-positive status: (ORa: 3.23, 95% CI; 1.27-8.45), and male gender: (ORa: 2.34, 95% CI; 1.26-8.16). For the group with NTM-PD due to MAC, improvement was associated with the duration of macrolide treatment (ORa: 3.27, 95% CI; 1

Predictive factors for a one-year improvement in nontuberculous mycobacterial pulmonary disease: An 11-year retrospective and multicenter study.

Directory of Open Access Journals (Sweden)

Gilbert Cadelis

2017-08-01

Full Text Available Nontuberculous mycobacterial pulmonary disease (NTM-PD has become an emerging infectious disease and is responsible for more deaths than tuberculosis in industrialized countries. NTM-PD mortality remains high in some series reportedly ranging from 25% to 40% at five years and often due to unfavorable evolution of NTM-PD despite established treatment. The purpose of our study was to search for early factors that could predict the favorable or unfavorable evolution of NTM-PD at the first year of treatment.In this retrospective and multicenter study, we selected 119 patients based on clinical, radiological and microbiological data from 2002 to 2012 from three French university hospitals (Guadeloupe, Martinique, Montpellier with definite (meeting the criteria of the American Thoracic Society and the Infectious Disease Society of America in 2007; ATS/IDSA or probable (one positive sputum culture NTM-PD. We compared two patient groups: those who improved at one year (clinical symptoms, radiological lesions and microbiology data and those who did not improve at one year. The data were analyzed for all patients as well as for subgroups by gender, HIV-positive patients, and Mycobacterium avium complex (MAC infection.The average patient age was 50 years ± 19.4; 58% had respiratory comorbidities, 24% were HIV positive and 19% had cystic fibrosis. Coughing concerned 66% of patients and bronchiectasis concerned 45%. The most frequently isolated NTM were MAC (46%. 57% (n = 68 of patients met the ATS criteria and improved status concerned 38.6% (n = 46. The improvement factors at one year of NTM-PD were associated with the duration of ethambutol treatment: (Odds ratio adjusted [ORa]: 2.24, 95% Confidence interval [CI]; 2.11-3.41, HIV-positive status: (ORa: 3.23, 95% CI; 1.27-8.45, and male gender: (ORa: 2.34, 95% CI; 1.26-8.16. For the group with NTM-PD due to MAC, improvement was associated with the duration of macrolide treatment (ORa: 3.27, 95% CI; 1

Theory of neoclassical tearing modes and its application to ITER-FEAT

International Nuclear Information System (INIS)

Pustovitov, V.D.; Mikhailovskii, A.B.; Konovalov, S.V.; Zvonkov, A.V.; Kobayashi, N.; Mukhovatov, V.S.

2001-01-01

Neoclassical tearing modes (NTM) can be responsible for beta limitation in long-pulse ITER discharges. The excitation and growth of NTM are governed by the competing bootstrap current, polarization current and so-called Δ' effects. Also, the magnetic well and Electron Cyclotron Current Drive (ECCD) can stabilize the NTM. We study analytically and numerically all the effects with a particular emphasis on the polarization current in the analytical part of our study. We show that the polarization current description requires a generalized transport theory including the hyperviscosity, electron pressure gradient and, as well, the finite ion Larmor radius effects in the perpendicular current. The profile function nonstationarity must be taken into account for calculation of the island rotation frequency. Results of numerical simulation of NTM suppression by modulated ECCD in ITER are presented. (author)

Tuberculosis and non-tuberculous mycobacteria among HIV-infected individuals in Ghana

DEFF Research Database (Denmark)

Bjerrrum, Stephanie; Oliver-Commey, Joseph; Kenu, Ernest

2016-01-01

OBJECTIVES: To assess the prevalence and clinical importance of previously unrecognised tuberculosis (TB) and isolation of non-tuberculous mycobacteria (NTM) among HIV-infected individuals in a teaching hospital in Ghana. METHODS: Intensified mycobacterial case finding was conducted among HIV...... for mycobacteria with smear microscopy, culture and Xpert MTB/RIF assay. NTM species were identified with the GenoType Mycobacterium CM/AS or sequence analysis of 16S rRNA gene. RESULTS: Of 473 participants, 60 (12.7%) had confirmed pulmonary TB, and 38 (8.0%) had positive cultures for NTM. Mycobacterium avium...... cell count, BMI, prolonged fever and ART initiation. CONCLUSIONS: Intensified mycobacterial screening of HIV-infected individuals revealed a high burden of unrecognised pulmonary TB before ART initiation, which increased risk of death within six months. NTM were frequently isolated and associated...

Influence of plasma rotation on tearing mode stability on the ASDEX upgrade tokamak

Energy Technology Data Exchange (ETDEWEB)

Fietz, Sina Marie Ariane

2013-12-16

Neoclassical tearing modes (NTM) are one of the most serious performance limiting instabilities in next-step fusion devices like ITER. NTMs are destabilised as a consequence of a seed perturbation (trigger) and are driven by a loss of helical bootstrap current inside the island. The appearance of these instabilities is accompanied with a loss of confined plasma energy. Additionally, these modes can stop the plasma rotation, lock to the vessel wall, flush out all plasma energy and terminate a discharge via a disruption. In ITER the confinement reduction will limit the achievable fusion power, whereas a disruption is likely to damage the vessel wall. In order to mitigate and control NTMs in ITER, extrapolations based on the present understanding and observations must be made. One key issue is the rotation dependence of NTMs, especially at the NTM onset. ITER will be operated at low plasma rotation, which is different from most present day experiments. No theory is currently available to describe this dependence. Experiments are therefore required to provide a basis for the theory to describe the physics. Additionally from the experiments scalings can be developed and extrapolated in order to predict the NTM behaviour in the parameter range relevant for ITER. Another important issue is the influence of externally applied magnetic perturbation (MP) fields on the NTM stability and frequency. These fields will be used in ITER primarily for the mitigation of edge instabilities. As a side effect they can slow down an NTM and the plasma rotation, which supports the appearance of locked modes. Additionally, they can also influence the stability of an NTM. This interaction has to be predicted for ITER, based on models validated at present day devices. In this work the influence of plasma rotation on the NTM onset at the ASDEX Upgrade tokamak (AUG) is investigated. An onset database has been created in which the different trigger mechanisms have been identified. Based on this

Influence of plasma rotation on tearing mode stability on the ASDEX upgrade tokamak

International Nuclear Information System (INIS)

Fietz, Sina Marie Ariane

2013-01-01

Neoclassical tearing modes (NTM) are one of the most serious performance limiting instabilities in next-step fusion devices like ITER. NTMs are destabilised as a consequence of a seed perturbation (trigger) and are driven by a loss of helical bootstrap current inside the island. The appearance of these instabilities is accompanied with a loss of confined plasma energy. Additionally, these modes can stop the plasma rotation, lock to the vessel wall, flush out all plasma energy and terminate a discharge via a disruption. In ITER the confinement reduction will limit the achievable fusion power, whereas a disruption is likely to damage the vessel wall. In order to mitigate and control NTMs in ITER, extrapolations based on the present understanding and observations must be made. One key issue is the rotation dependence of NTMs, especially at the NTM onset. ITER will be operated at low plasma rotation, which is different from most present day experiments. No theory is currently available to describe this dependence. Experiments are therefore required to provide a basis for the theory to describe the physics. Additionally from the experiments scalings can be developed and extrapolated in order to predict the NTM behaviour in the parameter range relevant for ITER. Another important issue is the influence of externally applied magnetic perturbation (MP) fields on the NTM stability and frequency. These fields will be used in ITER primarily for the mitigation of edge instabilities. As a side effect they can slow down an NTM and the plasma rotation, which supports the appearance of locked modes. Additionally, they can also influence the stability of an NTM. This interaction has to be predicted for ITER, based on models validated at present day devices. In this work the influence of plasma rotation on the NTM onset at the ASDEX Upgrade tokamak (AUG) is investigated. An onset database has been created in which the different trigger mechanisms have been identified. Based on this

Epidemiology of nontuberculous mycobacteria isolations among central North Carolina residents, 2006-2010

Science.gov (United States)

BACKGROUND: Nontuberculous mycobacteria (NTM) are environmental mycobacteria associated with a range of infections. Reports of NTM epidemiology have primarily focused on pulmonary infections and isolations, however extrapulmonary infections of the skin, soft tissues and sterile s...

Multidrug resistant tuberculosis versus non-tuberculous mycobacterial infections: a CT-scan challenge

International Nuclear Information System (INIS)

Kahkouee, Shahram; Esmi, Elham; Moghadam, Azadeh; Karam, Mehrdad Bakhshayesh; Mosadegh, Leila; Salek, Solmaz; Tabarsi, Payam

2013-01-01

Introduction: clinical, laboratory and imaging findings in patients with multidrug resistant tuberculosis (MDR-TB) and non-tuberculosis mycobacterium (NTM) are similar, and the majority of these patients present with positive smear for Acid Fast Bacilli (ADB) and no response to first line anti-TB treatment, so sputum culture and PCR are necessary, especially in NTM. Objective: In this study we evaluate more details of imaging findings to help earlier diagnosis of pathogens. Materials and methods: 66 patients with positive smear for AFB and no response to first line anti-TB drugs were divided into two groups by PCR and culture: MDR-TB (43 patients) and NTM (23 patients). Age, sex, history of anti-TB treatment, smoking and CT-scan findings (parenchymal, pleural and mediastinal variables) by details and lobar distribution were analyzed. Results: mean age of NTM patients was slightly higher (52 versus 45) and there is no significant difference in sex and smoking. In MDR-TB group, history of anti-TB treatment and evidence of chronic pulmonary disease such as calcified and fibrodestructed parenchyma, volume loss and pleural thickening were higher significantly. Cavities in MDR-TB were thick wall in the background of consolidation, while NTM cavities were more thin-walled with adjacent satellite nodules in same segment or lobe. Prevalence of bronchiectasis was similar in both groups, while bronchiectasis in MDR-TB group was in fibrobronchiectatic background in upper lobes, and in NTM group the distribution was more uniform with slightly middle lobes predominance. Prevalence and distribution of nodular infiltrations were similar more in Tree in Buds and scattered pattern. Calcified or non-calcified lymph nodes and also pleural changes were more frequent in MDR-TB but prevalence of lymphadenopathy was mildly higher in NTM. (author)

Multidrug resistant tuberculosis versus non-tuberculous mycobacterial infections: a CT-scan challenge

Energy Technology Data Exchange (ETDEWEB)

Kahkouee, Shahram; Esmi, Elham; Moghadam, Azadeh; Karam, Mehrdad Bakhshayesh; Mosadegh, Leila; Salek, Solmaz; Tabarsi, Payam, E-mail: bestlala@yahoo.com [Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Science, Tehran (Iran, Islamic Republic of)

2013-03-15

Introduction: clinical, laboratory and imaging findings in patients with multidrug resistant tuberculosis (MDR-TB) and non-tuberculosis mycobacterium (NTM) are similar, and the majority of these patients present with positive smear for Acid Fast Bacilli (ADB) and no response to first line anti-TB treatment, so sputum culture and PCR are necessary, especially in NTM. Objective: In this study we evaluate more details of imaging findings to help earlier diagnosis of pathogens. Materials and methods: 66 patients with positive smear for AFB and no response to first line anti-TB drugs were divided into two groups by PCR and culture: MDR-TB (43 patients) and NTM (23 patients). Age, sex, history of anti-TB treatment, smoking and CT-scan findings (parenchymal, pleural and mediastinal variables) by details and lobar distribution were analyzed. Results: mean age of NTM patients was slightly higher (52 versus 45) and there is no significant difference in sex and smoking. In MDR-TB group, history of anti-TB treatment and evidence of chronic pulmonary disease such as calcified and fibrodestructed parenchyma, volume loss and pleural thickening were higher significantly. Cavities in MDR-TB were thick wall in the background of consolidation, while NTM cavities were more thin-walled with adjacent satellite nodules in same segment or lobe. Prevalence of bronchiectasis was similar in both groups, while bronchiectasis in MDR-TB group was in fibrobronchiectatic background in upper lobes, and in NTM group the distribution was more uniform with slightly middle lobes predominance. Prevalence and distribution of nodular infiltrations were similar more in Tree in Buds and scattered pattern. Calcified or non-calcified lymph nodes and also pleural changes were more frequent in MDR-TB but prevalence of lymphadenopathy was mildly higher in NTM. (author)

Mycobacterium komaniense sp. nov., a rapidly growing non-tuberculous Mycobacterium species detected in South Africa.

Science.gov (United States)

Gcebe, Nomakorinte; Rutten, Victor P M G; van Pittius, Nicolaas Gey; Naicker, Brendon; Michel, Anita L

2018-05-01

Some species of non-tuberculous mycobacteria (NTM) have been reported to be opportunistic pathogens of animals and humans. Recently there has been an upsurge in the number of cases of NTM infections, such that some NTM species are now recognized as pathogens of humans and animals. From a veterinary point of view, the major significance of NTM is the cross-reactive immune response they elicit against Mycobacterium bovis antigens, leading to misdiagnosis of bovine tuberculosis. Four NTM isolates were detected from a bovine nasal swab, soil and water, during an NTM survey in South Africa. These were all found using 16S rRNA gene sequence analysis to be closely related to Mycobacterium moriokaense. The isolates were further characterised by sequence analysis of the partial fragments of hsp65, rpoB and sodA. The genome of the type strain was also elucidated. Gene (16S rRNA, hsp65, rpoB and sodA) and protein sequence data analysis of 6 kDa early secretory antigenic target (ESAT 6) and 10 kDa culture filtrate protein (CFP-10) revealed that these isolates belong to a unique Mycobacterium species. Differences in phenotypic and biochemical traits between the isolates and closely related species further supported that these isolates belong to novel Mycobacterium species. We proposed the name Mycobacterium komaniense sp. nov. for this new species. The type strain is GPK 1020 T (=CIP 110823T=ATCC BAA-2758).

Stabilization of neoclassical tearing modes by electron cyclotron current drive in JT-60U

International Nuclear Information System (INIS)

Isayama, A.; Oyama, N.; Urano, H.; Suzuki, T.; Takechi, M.; Hayashi, N.; Nagasaki, K.; Kamada, Y.; Ide, S.; Ozeki, T.

2007-01-01

Results of active control of neoclassical tearing modes (NTMs) by electron cyclotron current drive (ECCD) in JT-60U are described. Growth of an NTM with poloidal mode number m = 3 and toroidal mode number n = 2 has been suppressed by ECCD inside the sawtooth inversion radius in the co-direction, showing the possibility of the coexistence of sawtooth oscillations and a small-amplitude m/n = 3/2 NTM without large confinement degradation. Stabilization of an m/n = 2/1 NTM by ECCD at the mode rational surface has been demonstrated with a small ratio of the current density driven by the electron cyclotron (EC) wave to the local bootstrap current density (∼ 0.5). In addition, dependence of the stabilization effect on ECCD location has been investigated in detail. It has been found that an m/n = 2/1 NTM can be completely stabilized with the misalignment of the ECCD location less than about half of the full island width, and that the m/n = 2/1 NTM is destabilized with the misalignment comparable to the full island width. Time-dependent, self-consistent simulation of magnetic island evolution using the TOPICS code has shown that the stabilization and destabilization of an m/n = 2/1 NTM are well reproduced with the same set of coefficients of the modified Rutherford equation. The TOPICS simulation has also clarified that EC wave power required for complete stabilization can be significantly reduced by narrowing the ECCD deposition width

Validation of biomarkers for distinguishing Mycobacterium tuberculosis from non-tuberculous mycobacteria using gas chromatography-mass spectrometry and chemometrics.

Directory of Open Access Journals (Sweden)

Ngoc A Dang

Full Text Available Tuberculosis (TB remains a major international health problem. Rapid differentiation of Mycobacterium tuberculosis complex (MTB from non-tuberculous mycobacteria (NTM is critical for decisions regarding patient management and choice of therapeutic regimen. Recently we developed a 20-compound model to distinguish between MTB and NTM. It is based on thermally assisted hydrolysis and methylation gas chromatography-mass spectrometry and partial least square discriminant analysis. Here we report the validation of this model with two independent sample sets, one consisting of 39 MTB and 17 NTM isolates from the Netherlands, the other comprising 103 isolates (91 MTB and 12 NTM from Stellenbosch, Cape Town, South Africa. All the MTB strains in the 56 Dutch samples were correctly identified and the model had a sensitivity of 100% and a specificity of 94%. For the South African samples the model had a sensitivity of 88% and specificity of 100%. Based on our model, we have developed a new decision-tree that allows the differentiation of MTB from NTM with 100% accuracy. Encouraged by these findings we will proceed with the development of a simple, rapid, affordable, high-throughput test to identify MTB directly in sputum.

Nontuberculous mycobacteria: incidence in Southwest Ireland from 1987 to 2000.

LENUS (Irish Health Repository)

Kennedy, M P

2012-02-03

SETTING: The Southwest of Ireland (Counties Cork and Kerry) 1987-2000, average population 549,500. OBJECTIVE: Nontuberculous mycobacteria (NTM) cause significant morbidity worldwide and the study of epidemiology and characteristics helps in their prevention and treatment. This study was performed to determine the incidence of NTM disease in comparison to Mycobacterium tuberculosis (M. tuberculosis) and Mycobacterium bovis (M. bovis) in Southwest Ireland, over the above time period. DESIGN: A retrospective study was carried out in all human isolates of NTM, M. tuberculosis and M. bovis between 1987 and 2000, in the Southwest Region of Ireland. RESULTS: The mean incidence of NTM (0.4\\/100,000 population) has risen since 1995, principally of pulmonary Mycobacterium avium intracellulare complex (MAC). The annual incidence of M. tuberculosis in humans over 14 years in the same region was 971\\/100,000 population with a significant reduction since 1994 and M. bovis remained constant at 0.5\\/100,000 population. CONCLUSION: The increasing incidence of disease causing NTM noted in Southwest Ireland reflects global data and is surmised to be due to an ageing population, increased incidence related to chronic fibrotic lung disease, and environmental mycobacterial factors.

Non-tuberculous mycobacterial soft tissue swelling in an immunocompetent patient

Directory of Open Access Journals (Sweden)

Virendra S Athavale

2014-01-01

Full Text Available Non-tuberculosis mycobacteria (NTM include those mycobacterium species that are not members of the Mycobacterium tuberculosis complex. They assumed significance with the growing pandemic of the acquired immune deficiency syndrome (AIDS since the 1980s, when Mycobacterium avium infections were found to be associated with AIDS. However, the epidemiology of NTM disease among patients without Human immunodeficiency virus infections is not well documented. We report a case of NTM soft tissue swelling in an immunocompetent 18-year-old male who responded well to local excision and antitubercular treatment.

Nontuberculous Mycobacterial Disease Is Not a Contraindication to Lung Transplantation in Patients With Cystic Fibrosis

DEFF Research Database (Denmark)

Qvist, Tavs; Pressler, Tanja; Thomsen, V O

2013-01-01

of these died of non-NTM-related causes whereas two developed deep Mycobacterium abscessus wound infections and one was transiently culture negative until M abscessus was reactivated. One patient was subsequently cured; the other two remained on therapy with good performance status. The study supports...... infection poses a contraindication to lung transplantation. All CF patients with current or prior NTM who had undergone lung transplantation were identified. Out of 52 lung transplant patients with CF 9 (17%) had NTM disease. Five patients had known infection at the time of transplantation. Two...

Nontuberculous Mycobacterial Infection in Children A Prospective National Study

NARCIS (Netherlands)

Blyth, Christopher C.; Best, Emma J.; Jones, Cheryl A.; Nourse, Clare; Goldwater, Paul N.; Daley, Andrew J.; Burgner, David; Henry, Guy; Palasanthiran, Pamela

Background: The epidemiology and management of nontuberculous mycobacterial (NTM) infection in Australian children is unknown. Methods: From July 2004 to June 2007, clinicians identified children with NTM infection as part of a nationwide active surveillance network. Following notification, detailed

Die neue CSR-Richtlinie – Erhöhung der Unternehmenstransparenz in Sozial- und Umweltbelangen / Alexander Eufinger

Index Scriptorium Estoniae

Eufinger, Alexander

2015-01-01

Euroopa Liidu direktiivist, mis käsitleb finantsteabe avalikustamist teatavate suurettevõtjate ja kontsernide poolt (2014/95) ning eriti ettevõtjate poolt esitatava sotsiaalse ja keskkonnaalase teabe läbipaistvusest

Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

DEFF Research Database (Denmark)

Qvist, Tavs; Gilljam, Marita; Jönsson, Bodil

2015-01-01

BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from...

Utility of rpoB Gene Sequencing for Identification of Nontuberculous Mycobacteria in the Netherlands

NARCIS (Netherlands)

Zwaan, R. de; Ingen, J. van; Soolingen, D. van

2014-01-01

In the Netherlands, clinical isolation of nontuberculous mycobacteria (NTM) has increased over the past decade. Proper identification of isolates is important, as NTM species differ strongly in clinical relevance. Most of the currently applied identification methods cannot distinguish between all

THE PERSISTENCE OF MYCOBACTERIUM AVIUM IN A DRINKING WATER SYSTEM AFTER THE ADDITION OF FILTRATION

Science.gov (United States)

Drinking water is increasingly recognized as a major source of pathogenic nontuberculous mycobacteria (NTM) associated with human infection. Our goal was to determine if the prevalence of NTM would decrease after the addition of filtration treatment to an unfiltered surface water...

Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria.

NARCIS (Netherlands)

Ingen, J. van; Boeree, M.J.; Soolingen, D. van; Mouton, J.W.

2012-01-01

Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans. For most NTM infections the therapy of choice is drug treatment, but treatment regimens differ by species, in particular between slow (e.g. Mycobacterium avium complex,

THE PERSISTENCE OF MYCOBACTERIUM AVIUM IN A DRINKING WATER DISTRIBUTION SYSTEM AFTER THE ADDITION OF FILTRATION TREATMENT

Science.gov (United States)

There is evidence that drinking water may be a source of pathogenic nontuberculous mycobacteria (NTM) infections in humans. One method by which NTM are believed to enter drinking water distribution systems is by their intracellular location within protozoa. Our goal was to determ...

Isolation of mycobacteria other than Mycobacterium avium from porcine lymph nodes

NARCIS (Netherlands)

Ingen, van J.; Wisselink, H.J.; Solt-Smits, van C.B.; Boeree, M.J.; Soolingen, D.

2010-01-01

Mycobacterium avium causes lymphadenitis in pigs. This presents an economical burden, as these pigs meat is considered inappropriate for consumption. In humans, lymphadenitis due to nontuberculous mycobacteria (NTM) primarily affects children and is caused by a variety of NTM, though M. avium

Isolation of mycobacteria other than Mycobacterium avium from porcine lymph nodes.

NARCIS (Netherlands)

Ingen, J. van; Wisselink, H.J.; Solt-Smits, C.B. van; Boeree, M.J.; Soolingen, D. van

2010-01-01

Mycobacterium avium causes lymphadenitis in pigs. This presents an economical burden, as these pigs meat is considered inappropriate for consumption. In humans, lymphadenitis due to nontuberculous mycobacteria (NTM) primarily affects children and is caused by a variety of NTM, though M. avium

Flavored E-cigarette Use and Cigarette Smoking Reduction and Cessation-A Large National Study among Young Adult Smokers.

Science.gov (United States)

Chen, Julia Cen

2018-04-06

E-cigarette use prevalence has increased drastically among young adult cigarette smokers in recent years. This study seeks to understand which e-cigarette flavors-sweet and fruity or tobacco and menthol/mint-are more likely to be associated with smoking reduction and cessation among young adults. Longitudinal data (waves 1 and 2) of the Population Assessment of Tobacco and Health (PATH) Study from young adult (aged 18-34) cigarette smokers (n = 4,645) at wave 1 and current e-cigarette users (n = 844) at wave 2 were used. Univariate and multivariate regressions were conducted to examine the associations between past-year smoking reduction and cessation and current e-cigarette flavor use at wave 2. At wave 2, 25.9% of respondents either reduced or quit smoking, and 6.7%, 5.2%, and 6.3% of them reported currently using e-cigarettes with tobacco/menthol (TM) flavors, one non-tobacco/non-menthol (NTM) flavor, and multiple NTM flavors, respectively. E-cigarette users with one (AOR = 2.5, p e-cigarette users. NTM flavor use was positively associated with e-cigarette use of a higher frequency and larger amount. The positive association between past-year smoking reduction and cessation and current NTM flavored e-cigarette use may be explained by young adults' escalated e-cigarette use with NTM flavors. Public health professionals should prevent and reduce multiple tobacco use through enhanced education about the harm of vaping NTM flavors and by advising young adult smokers to quit tobacco altogether using evidence-based methods.

Genotyping and drug susceptibility testing of mycobacterial isolates from population-based tuberculosis prevalence survey in Ghana.

Science.gov (United States)

Addo, Kennedy Kwasi; Addo, Samuel Ofori; Mensah, Gloria Ivy; Mosi, Lydia; Bonsu, Frank Adae

2017-12-02

Mycobacterium tuberculosis complex (MTBC) and Non-tuberculosis Mycobacterium (NTM) infections differ clinically, making rapid identification and drug susceptibility testing (DST) very critical for infection control and drug therapy. This study aims to use World Health Organization (WHO) approved line probe assay (LPA) to differentiate mycobacterial isolates obtained from tuberculosis (TB) prevalence survey in Ghana and to determine their drug resistance patterns. A retrospective study was conducted whereby a total of 361 mycobacterial isolates were differentiated and their drug resistance patterns determined using GenoType Mycobacterium Assays: MTBC and CM/AS for differentiating MTBC and NTM as well MTBDRplus and NTM-DR for DST of MTBC and NTM respectively. Out of 361 isolates, 165 (45.7%) MTBC and 120 (33.2%) NTM (made up of 14 different species) were identified to the species levels whiles 76 (21.1%) could not be completely identified. The MTBC comprised 161 (97.6%) Mycobacterium tuberculosis and 4 (2.4%) Mycobacterium africanum. Isoniazid and rifampicin monoresistant MTBC isolates were 18/165 (10.9%) and 2/165(1.2%) respectively whiles 11/165 (6.7%) were resistant to both drugs. Majority 42/120 (35%) of NTM were M. fortuitum. DST of 28 M. avium complex and 8 M. abscessus complex species revealed that all were susceptible to macrolides (clarithromycin, azithromycin) and aminoglycosides (kanamycin, amikacin, and gentamicin). Our research signifies an important contribution to TB control in terms of knowledge of the types of mycobacterium species circulating and their drug resistance patterns in Ghana.

Failure to recognize nontuberculous mycobacteria leads to misdiagnosis of chronic pulmonary tuberculosis.

Directory of Open Access Journals (Sweden)

Mamoudou Maiga

Full Text Available BACKGROUND: Nontuberculous mycobacterial (NTM infections cause morbidity worldwide. They are difficult to diagnose in resource-limited regions, and most patients receive empiric treatment for tuberculosis (TB. Our objective here is to evaluate the potential impact of NTM diseases among patients treated presumptively for tuberculosis in Mali. METHODS: We re-evaluated sputum specimens among patients newly diagnosed with TB (naïve and those previously treated for TB disease (chronic cases. Sputum microscopy, culture and Mycobacterium tuberculosis drug susceptibility testing were performed. Identification of strains was performed using molecular probes or sequencing of secA1 and/or 16S rRNA genes. RESULTS: Of 142 patients enrolled, 61 (43% were clinically classified as chronic cases and 17 (12% were infected with NTM. Eleven of the 142 (8% patients had NTM disease alone (8 M. avium, 2 M. simiae and 1 M. palustre. All these 11 were from the chronic TB group, comprising 11/61 (18% of that group and all were identified as candidates for second line treatment. The remaining 6/17 (35.30% NTM infected patients had coinfection with M. tuberculosis and all 6 were from the TB treatment naïve group. These 6 were candidates for the standard first line treatment regimen of TB. M. avium was identified in 11 of the 142 (8% patients, only 3/11 (27.27% of whom were HIV positive. CONCLUSIONS: NTM infections should be considered a cause of morbidity in TB endemic environments especially when managing chronic TB cases to limit morbidity and provide appropriate treatment.

Zaarkanit li "Mongol" "Oskara"? / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2008-01-01

Nikita Mihhalkovi mängufilm "12" on Venemaa poolt võõrfilmi Oscari kandidaat, Kasahstani poolt aga "Mongol", mille režissöör on samuti venelane Sergei Bodrov. Põhjalik arvustus viimasest filmist

Effect of ion viscosity on neoclassical tearing mode

International Nuclear Information System (INIS)

Yoshida, Shigeki; Itoh, Sanae-I.; Yagi, Masatoshi; Azumi, Masafumi

2004-01-01

Linear stability analysis of neoclassical tearing mode (NTM) is performed on the basis of four-field reduced magnetohydrodynamic (MHD) model which takes account of fluctuating ion parallel flow and ion neoclassical viscosity. The dependence of the growth rate on the kinetic effects is investigated. It is shown that the linear NTM is stabilized by ion neoclassical viscosity and that the stabilizing effect of ion parallel compressibility is weak in the banana-plateau regime. It is found that not only ion neoclassical viscosity but also both ion and electron diamagnetic effects are important for the stabilization of NTM. (author)

The Front Steering Launcher Design for the ITER ECRH Upper Port

International Nuclear Information System (INIS)

Henderson, M A; Chavan, R; Heidinger, R; Nikkola, P; Ramponi, G; Saibene, G; Sanchez, F; Sauter, O; Serikov, A; Zohm, H

2005-01-01

The ECRH ITER upper port antenna's role is to stabilize the neoclassical tearing mode (NTM) on either the q = 2 or 3/2 rational flux surfaces, which requires a narrow current deposition profile (j CD ) over a wide range along the resonance surfaces. The width of j CD should be equivalent to the marginal island width to fully stabilise the NTM. Two antenna concepts are under consideration for the upper port launcher: front steering (FS) and remote steering (RS). The FS launcher decouples the steering and focusing aspects using a two mirror system (one focusing and one steering), achieving a wider steering range and higher current density for NTM stabilisation than required by ITER, offering a threefold increase in NTM stabilization efficiency over the RS launcher. The improved physics performance has motivated the further design study of the FS launcher aiming toward a build to print launcher. The present design is compatible with ≥2.0 MW CW operation and 8 beams per port plug. A frictionless backlashfree system is envisioned for the steering mechanism. An overview of the launcher design, the calculated physics performance and the possibility of using the upper port launcher for extended physics applications (beyond NTM stabilisation) are discussed

Kliendirahulolu küsitlus = Customer satisfaction survey / Tiina Tambaum

Index Scriptorium Estoniae

Tambaum, Tiina

2005-01-01

Ülevaade Maksu- ja Tolliameti poolt läbiviidud juriidilistest isikutest klientide rahulolu uuringust, uuringukeskuse Faktum poolt korraldatud tolliklientide telefoniküsitlusest ning koostöös konsultatsioonifirmaga Fontes toimunud töötajate rahulolu uuringust

Vangi dilemma / Andra Veidemann

Index Scriptorium Estoniae

Veidemann, Andra, 1955-

2003-01-01

Pidev konkurents hävitab usaldust. Tuleb leida tasakaal ühelt poolt turumajanduse võistlusele rajaneva ja teiselt poolt perede ning kogukondade rüpes kujuneva koostöövaimu vahel. Eesti ühiskonna lõhenemine

Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis

DEFF Research Database (Denmark)

Qvist, Tavs; Pressler, Tania; Høiby, Niels

2014-01-01

. Currently several key areas are being revised: The first outbreak of human NTM transmission has been proven and new evidence of biofilm growth in vivo has been demonstrated. A better understanding of the clinical impact of NTM infection has led to increased diagnostic vigilance and new recommendations...

A spatial epidemiological analysis of nontuberculous mycobacterial infections in Queensland, Australia.

Science.gov (United States)

Chou, Michael P; Clements, Archie C A; Thomson, Rachel M

2014-05-21

The epidemiology of infections with nontuberculous mycobacteria (NTM) has been changing and the incidence has been increasing in some settings. The main route of transmission to humans is considered to be from the environment. We aimed to describe spatial clusters of cases of NTM infections and to identify associated climatic, environmental and socio-economic variables. NTM data were obtained from the Queensland Mycobacterial Reference Laboratory for the period 2001-2011. A Bayesian spatial conditional autoregressive model was constructed at the postcode level, with covariates including soil variables, maximum, mean and minimum rainfall and temperature, income (proportion of population earning Queensland region overlying the Surat sub-division of the Great Artesian Basin, as well as in the lower North Queensland Local Government Area known as the Whitsunday region. Our models estimated an expected increase of 21% per percentage increase of population earning Queensland, and a number of socio-ecological, economic and environmental factors were found to be associated with NTM infection risk.

Kto tam shagajet levoi? Pravoi! Pravoi! / Oleg Samorodni

Index Scriptorium Estoniae

Samorodni, Oleg, 1961-

2006-01-01

Faktum & Ariko poolt läbi viidud uuringust selgus, et Eesti elanikud eelistavad Riigikogu valimistel hääletada pigem parempoolsete parteide poolt. Autor analüüsib parem- ja vasakpoolsete parteide ideoloogia olemust Eesti ühiskonnas

Eestlased saadeti Marimaalt segaste põhjendustega välja / Jaak Prozes

Index Scriptorium Estoniae

Prozes, Jaak, 1965-

2005-01-01

Eesti Kunstiakadeemia poolt korraldatud 28. soome-ugri ekspeditsioon lõppes 17 Kunstiakadeemia tudengi väljasaatmisega Marimaalt kohalike võimude poolt. Lisa: Mõni marikeelne raamat aastas. Vt. samas: Rein Sikk. Suur mees, kes armastab väikseid

Nagu kaks tilka vett

Index Scriptorium Estoniae

2006-01-01

Valie Export Society poolt valitud tekst noore eesti kunsti kohta 1980. aastate ajalehtedest "Sirp ja Vasar" ning 2006. a. Tallinnas Kaasaegse Kunsti Eesti Keskuse poolt väljaantud artiklikogumikust "Uue nimetaja otsinguid aastal 2000+n : lisandusi eesti kunstiloole"

Nontuberculous mycobacterial species and Mycobacterium tuberculosis complex coinfection in patients with pulmonary tuberculosis in Dr. Soetomo Hospital, Surabaya, Indonesia

Directory of Open Access Journals (Sweden)

Ni Made Mertaniasih

2017-01-01

Full Text Available Objective/Background: The aim of this study was to analyze the detection of nontuberculous mycobacterial (NTM species derived from sputum specimens of pulmonary tuberculosis (TB suspects. Increasing prevalence and incidence of pulmonary infection by NTM species have widely been reported in several countries with geographical variation. Materials and Methods: Between January 2014 and September 2015, sputum specimens from chronic pulmonary TB suspect patients were analyzed. Laboratory examination of mycobacteria was conducted in the TB laboratory, Department of Clinical Microbiology, Dr. Soetomo Hospital, Surabaya. Detection and identification of mycobacteria were performed by the standard culture method using the BACTEC MGIT 960 system (BD and Lowenstein–Jensen medium. Identification of positive Mycobacterium tuberculosis complex (MTBC was based on positive acid-fast bacilli microscopic smear, positive niacin accumulation, and positive TB Ag MPT 64 test results (SD Bioline. If the growth of positive cultures and acid-fast bacilli microscopic smear was positive, but niacin accumulation and TB Ag MPT 64 (SD Bioline results were negative, then the isolates were categorized as NTM species. MTBC isolates were also tested for their sensitivity toward first-line anti-TB drugs, using isoniazid, rifampin, ethambutol, and streptomycin. Results: From 2440 sputum specimens of pulmonary TB suspect patients, 459 isolates (18.81% were detected as MTBC and 141 (5.78% as NTM species. Conclusion: From the analyzed sputum specimens, 18.81% were detected as MTBC and 5.78% as NTM species. Each pulmonary TB suspect patient needed clinical settings to suspect causative agents of MTBC and/or NTM species; clinicians have to understand the local epidemiological data for the evaluation of causes of lung infection to determine appropriate therapy.

[Identification of mycobacteria to the species level by molecular methods in the Public Health Laboratory of Bogotá, Colombia].

Science.gov (United States)

Hernández-Toloza, Johana Esther; Rincón-Serrano, María de Pilar; Celis-Bustos, Yamile Adriana; Aguillón, Claudia Inés

2016-01-01

Global epidemiology of non-tuberculous mycobacteria (NTM) is unknown due to the fact that notification is not required in many countries, however the number of infection reports and outbreaks caused by NTM suggest a significant increase in the last years. Traditionally, mycobacteria identification is made through biochemical profiles which allow to differentiate M. tuberculosis from NTM, and in some cases the mycobacteria species. Nevertheless, these methods are technically cumbersome and time consuming. On the other hand, the introduction of methods based on molecular biology has improved the laboratory diagnosis of NTM. To establish the NTM frequency in positive cultures for acid-fast bacilli (AAFB) which were sent to Laboratorio de Salud Pública de Bogotá over a 12 month period. A total of 100 positive cultures for acid-fast bacilli from public and private hospitals from Bogotá were identified by both biochemical methods and the molecular methods PRA (PCR-restriction enzyme analysis) and multiplex-PCR. Furthermore, low prevalence mycobacteria species and non-interpretable results were confirmed by 16SrDNA sequentiation analysis. Identification using the PRA method showed NMT occurrence in 11% of cultures. In addition, this molecular methodology allowed to detect the occurrence of more than one mycobacteria in 4% of the cultures. Interestingly, a new M. kubicae pattern of PCR-restriction analysis is reported in our study. Using a mycobacteria identification algorithm, which includes the molecular method PRA, improves the diagnostic power of conventional methods and could help to advance both NTM epidemiology knowledge and mycobacteriosis control. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

DVD. Aare Ermel soovitab "Meie isade lipud", "Kirjad Iwo Jimalt" / Aare Ermel

Index Scriptorium Estoniae

Ermel, Aare, 1957-2013

2007-01-01

Clint Eastwoodi kaks filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006

DVD. "Meie isade lipud" / "Kirjad Iwo Jimalt" / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2007-01-01

Clint Eastwoodi kaks filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006

Tööjõu liikuvus Euroopa Liidus / Tereza Nesterko

Index Scriptorium Estoniae

Nesterko, Tereza

2007-01-01

Tööjõu mobiilsusest Euroopa Liidus ja Eestis. Konsultatsioonifirma PricewaterhouseCoopers poolt 2002. aastal läbi viidud Euroopa tööjõu mobiilsust käsitleva uuringu tulemused ja uuringufirma SaarPoll poolt Eestis korraldatud küsitlusuuringust

Filmõ Mihhalkova i Bodrova nominirovanõ na premiju "Oskar"

Index Scriptorium Estoniae

2008-01-01

Nikita Mihhalkovi mängufilm "12" on Venemaa poolt võõrfilmi Oscari kandidaat, Kasahstani poolt aga "Mongol", mille režissöör on samuti venelane Sergei Bodrov. Mõlemad on valitud 9 filmi hulka, millest 22.01. nomineeritakse viis

Reabilitatsija poka ne udalass / Aleksandr Shegedin

Index Scriptorium Estoniae

Shegedin, Aleksandr

2006-01-01

Riigikogu lükkas tagasi Isamaaliidu ja SDE fraktsioonide poolt esitatud eelnõu, mis oleks andnud isikutele, kes olid võitluses Eesti Vabariigi iseseisvuse eest nõukogude kohtute poolt süüdimõistetud, täiendava võimaluse rehabiliteerimistaotluste esitamiseks

Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity.

Science.gov (United States)

Kwon, Yong-Soo; Cho, Young-Nan; Kim, Moon-Ju; Jin, Hye-Mi; Jung, Hyun-Ju; Kang, Jeong-Hwa; Park, Ki-Jeong; Kim, Tae-Jong; Kee, Hae Jin; Kim, Nacksung; Kee, Seung-Jung; Park, Yong-Wook

2015-05-01

Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. The aims of this study were to examine the levels of MAIT cells in pulmonary tuberculosis (TB) and nontuberculous mycobacteria (NTM) lung disease patients, to evaluate the clinical relevance of MAIT cell levels, and to investigate the functions of MAIT cells. Patients with pulmonary TB (n = 35), NTM (n = 29), and healthy controls (n = 75) were enrolled in the study. MAIT cell levels and functions were measured by flow cytometry. Circluating MAIT cell levels were found to be reduced in TB and NTM patients. MAIT cell deficiency reflects a variety of clinical conditions. In particular, MAIT cell numbers were significantly correlated with sputum AFB positivity, extent of disease, hemoglobin levels, lymphocyte counts, CRP and ESR levels. MAIT cells in TB patients failed to produce interferon-γ irrespective of the mode of stimulation, whereas NTM patients displayed a defect in MR1-dependent signaling pathway. Notably, an elevated expression of programmed death-1 was also associated with MAIT cell deficiency in TB. This study shows that MAIT cells are numerically and functionally deficient in TB and NTM patients and these deficiencies could contribute to immune system dysreguation in mycobacterial infection. Copyright © 2015 Elsevier Ltd. All rights reserved.

Mycobacterium malmesburyense sp. nov., a non-tuberculous species of the genus Mycobacterium revealed by multiple gene sequence characterization.

Science.gov (United States)

Gcebe, Nomakorinte; Rutten, Victor; Pittius, Nicolaas Gey van; Naicker, Brendon; Michel, Anita

2017-04-01

Non-tuberculous mycobacteria (NTM) are ubiquitous in the environment, and an increasing number of NTM species have been isolated and characterized from both humans and animals, highlighting the zoonotic potential of these bacteria. Host exposure to NTM may impact on cross-reactive immune responsiveness, which may affect diagnosis of bovine tuberculosis and may also play a role in the variability of the efficacy of Mycobacterium bovis BCG vaccination against tuberculosis. In this study we characterized 10 NTM isolates originating from water, soil, nasal swabs of cattle and African buffalo as well as bovine tissue samples. These isolates were previously identified during an NTM survey and were all found, using 16S rRNA gene sequence analysis to be closely related to Mycobacterium moriokaense. A polyphasic approach that included phenotypic characterization, antibiotic susceptibility profiling, mycolic acid profiling and phylogenetic analysis of four gene loci, 16S rRNA, hsp65, sodA and rpoB, was employed to characterize these isolates. Sequence data analysis of the four gene loci revealed that these isolates belong to a unique species of the genus Mycobacterium. This evidence was further supported by several differences in phenotypic characteristics between the isolates and the closely related species. We propose the name Mycobacterium malmesburyense sp. nov. for this novel species. The type strain is WCM 7299T (=ATCC BAA-2759T=CIP 110822T).

OurTube / David Talbot

Index Scriptorium Estoniae

Talbot, David

2009-01-01

USA California Ülikooli töötajate Abram Stern'i ja Michael Dale'i poolt 2005. a. algatatud USA kongressis peetud kõnede videoremiksidest ja nende poolt loodud veebisaidist Metavid.org. Ka YouTube keskkonnast ja wikipedia katsetustest muuta oma keskkond multimeedialisemaks

Riia-Moskva postitüli Põhjasõja eelõhtul / Enn Küng

Index Scriptorium Estoniae

Küng, Enn

2006-01-01

Haagi saadiku Andrei Matvejev'i poolt 1701. a. propagandateose sissejuhatuses esitatud Põhjasõja algatamise ettekäänetest. Rootsi ja Venemaa vahelisest postiühendusest, postmeistrite omavahelisest vastuolust ning selle kasutamisest Venemaa poolt ühe Põhjasõja alustamise võimaliku põhjendusena

Raimo Pullati XX "Vana Tallinn" / Tõnis Liibek

Index Scriptorium Estoniae

Liibek, Tõnis

2009-01-01

Ilmus professor Raimo Pullati poolt välja antava linnaajalugu ja -kultuuri tutvustava sarja "Vana Tallinn" XX köide. Tšehhi Teaduste Akadeemia raamatukogus toimus Raimo Pullati poolt välja antud entsüklopeedilise suurteose "Johann Christoph Brotze. Estonica" esitlus

Eastwood kritiseerib sõjavaatemänge / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2007-01-01

Clint Eastwoodi kaks viimast filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud ebavõrdse lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006

Muuseum sihtasutuseks : poolt ja vastu / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2002-01-01

Loodavast sihtasutusest Virumaa Muuseum, kuhu kuuluvad Palmse mõis, Rakvere muuseum, linnus, linnakodaniku muuseum, Richard Sagritsa talumuusem Karepal, Altja kõrts ja võrgukuurid ning ilmselt hakkavad kuuluma Käsmu muuseum ja Annikvere koolimaja. Kunstiteadlase M. Raisma, Sagritsa talumuuseumi töötaja A. Kiisi ja Vabaõhumuuseumi direktori M. Langi arvamus

Õiguskantsleri arvates on peaminister rikkunud põhiseadust / Mati Määrits

Index Scriptorium Estoniae

Määrits, Mati, 1958-

1994-01-01

Eerik-Juhan Truuväli vastas Riigikogu liikme Jüri E. Põllu arupärimisele peaminister Mart Laari poolt 'Finest Hotel Groupi' laenu garanteerimise kohta ja K. Jaak Roosaare arupärimisele presidendi poolt ministrite vahetuse kinnitamata jätmise kohta, 21. veebruar 1994

296 kilomeetrit vabariigi presidendini ehk Kuidas Misso valla valijamees Ere Käis riigipea paika pani / Rainer Kerge

Index Scriptorium Estoniae

Kerge, Rainer, 1977-

2006-01-01

Kuigi Misso valla volikogu andis oma valijamehele, Misso Keskkooli direktorile Ere Käisele mandaadi hääletada president Arnold Rüütli poolt, ei avalikusta valijamees, kumba kandidaadi poolt ta oma hääle andis. Kaart: Misso valla valijamehe tee Estoniasse - 296 kilomeetrit

Nähtamatu revolutsioon autotööstuses / Villu Zirnask

Index Scriptorium Estoniae

Zirnask, Villu, 1966-

2009-01-01

Autotootjatel tuleb leida lahendused suurele tehnoloogilisele väljakutsele, mis tuleneb ühelt poolt vajadusest vähendada autode CO₂ emissiooni, teiselt poolt aga sellest, et naftahinna leevenemine jääb tõenäoliselt ajutiseks. Tabel: Uued tehnoloogiad vs. traditsiooniline sisepõlemismootor

Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis.

Science.gov (United States)

Andréjak, Claire; Nielsen, Rikke; Thomsen, Vibeke Ø; Duhaut, Pierre; Sørensen, Henrik Toft; Thomsen, Reimar Wernich

2013-03-01

Chronic respiratory disease and inhaled corticosteroid (ICS) therapy for chronic obstructive pulmonary disease (COPD) increase the risk of pneumonia. Few data are available on the association of these risk factors with non-tuberculous mycobacterial (NTM) pulmonary disease. This study examined chronic respiratory diseases and ICS use as risk factors in a population-based case-control study encompassing all adults in Denmark with microbiologically confirmed NTM pulmonary disease between 1997 and 2008. The study included 10 matched population controls per case. Conditional logistic regression was used to compute adjusted ORs for NTM pulmonary disease with regard to chronic respiratory disease history. Overall, chronic respiratory disease was associated with a 16.5-fold (95% CI 12.2 to 22.2) increased risk of NTM pulmonary disease. The adjusted OR for NTM disease was 15.7 (95% CI 11.4 to 21.5) for COPD, 7.8 (95% CI 5.2 to 11.6) for asthma, 9.8 (95% CI 2.03 to 52.8) for pneumoconiosis, 187.5 (95% CI 24.8 to 1417.4) for bronchiectasis, and 178.3 (95% CI 55.4 to 574.3) for tuberculosis history. ORs were 29.1 (95% CI 13.3 to 63.8) for patients with COPD on current ICS therapy and 7.6 (95% CI 3.4 to 16.8) for patients with COPD who had never received ICS therapy. Among patients with COPD, ORs increased according to ICS dose, from 28.1 for low-dose intake to 47.5 for high-dose intake (more than 800 μg/day). The OR was higher for fluticasone than for budesonide. Chronic respiratory disease, particularly COPD treated with ICS therapy, is a strong risk factor for NTM pulmonary disease.

[A study of the value of three molecular diagnostic techniques in the diagnosis of tuberculosis].

Science.gov (United States)

Huang, Fang; Dang, Liyun; Sun, Huiping; Yang, Han; Wu, Xia

2015-09-01

To evaluate the diagnostic value of real-time fluorescent RNA isothermal amplification detection technology (simultaneous amplification and testing, SAT), Mycobacterium nucleic acid detection (PCR-fluorescence probe)method (TB-NTM-PCR) and Xpert MTB/RIF detection in the diagnosis of tuberculosis. A total of 378 sputum specimens from pulmonary tuberculosis patients were collected between April to July 2014 in Xi'an Thoracic Tumor and Tuberculosis Hospital. The specimens were detected by 5 methods at the same time including acid-fast stain, SAT method, TB-NTM-PCR method, TB 960 rapid liquid culture and Xpert MTB/RIF. The sensitivity and specificity of SAT method, TB-NTM-PCR method and Xpert MTB/RIF were calculated according to the results of TB 960 rapid liquid culture and staining. The difference among all the 3 methods was analyzed by Chi-squared test. The positive rate of SAT-TB,TB-NTM-PCR and Xpert MTB/RIF were 37.6% (142/378), 37.8% (143/378) and 53.4% (202/378), respectively. In specimens both positive for acid-fast stain and culture, the positive rate of SAT method was 84.6% (77/91), that of TB-NTM-PCR was 91.2% (83/91), and that of Xpert MTB/RIF was 96.7% (88/91), the difference being significant (P=0.018 2). In specimens negative for acid-fast stain but positive for culture, the positive rate of SAT method was 61.9% (60 /97), that of TB-NTM-PCR was 44.3% (43/97), and that of Xpert MTB/RIF was 80.4% (78/97), the difference being significant (Pmolecular detection methods showed good results for the auxiliary diagnosis of tuberculosis. Xpert MTB/RIF had the best performance both in smear positive and negative specimens and it can detect rifampicin related rpoB gene mutations at the same time.

Pragmatically Applied Cervical and Thoracic Nonthrust Manipulation Versus Thrust Manipulation for Patients With Mechanical Neck Pain: A Multicenter Randomized Clinical Trial.

Science.gov (United States)

Griswold, David; Learman, Ken; Kolber, Morey J; O'Halloran, Bryan; Cleland, Joshua A

2018-03-01

Study Design Randomized clinical trial. Background The comparative effectiveness between nonthrust manipulation (NTM) and thrust manipulation (TM) for mechanical neck pain has been investigated, with inconsistent results. Objective To compare the clinical effectiveness of concordant cervical and thoracic NTM and TM for patients with mechanical neck pain. Methods The Neck Disability Index (NDI) was the primary outcome. Secondary outcomes included the Patient-Specific Functional Scale (PSFS), numeric pain-rating scale (NPRS), deep cervical flexion endurance (DCF), global rating of change (GROC), number of visits, and duration of care. The covariate was clinical equipoise for intervention. Outcomes were collected at baseline, visit 2, and discharge. Patients were randomly assigned to receive either NTM or TM directed at the cervical and thoracic spines. Techniques and dosages were selected pragmatically and applied to the most symptomatic level. Two-way mixed-model analyses of covariance were used to assess clinical outcomes at 3 time points. Analyses of covariance were used to assess between-group differences for the GROC, number of visits, and duration of care at discharge. Results One hundred three patients were included in the analyses (NTM, n = 55 and TM, n = 48). The between-group analyses revealed no differences in outcomes on the NDI (P = .67), PSFS (P = .26), NPRS (P = .25), DCF (P = .98), GROC (P = .77), number of visits (P = .21), and duration of care (P = .61) for patients with mechanical neck pain who received either NTM or TM. Conclusion NTM and TM produce equivalent outcomes for patients with mechanical neck pain. The trial was registered with ClinicalTrials.gov (NCT02619500). Level of Evidence Therapy, level 1b. J Orthop Sports Phys Ther 2018;48(3):137-145. Epub 6 Feb 2018. doi:10.2519/jospt.2018.7738.

Time-dependent simulations of feedback stabilization of neoclassical tearing modes in KSTAR plasmas

Energy Technology Data Exchange (ETDEWEB)

Kim, Kyungjin [Department of Nuclear Engineering, Seoul National University, Seoul (Korea, Republic of); Na, Yong-Su, E-mail: ysna@snu.ac.kr [Department of Nuclear Engineering, Seoul National University, Seoul (Korea, Republic of); Kim, Hyun-Seok [Department of Nuclear Engineering, Seoul National University, Seoul (Korea, Republic of); Maraschek, M. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Garching bei München (Germany); Park, Y.S. [Department of Applied Physics and Applied Mathematics, Columbia University, New York (United States); Stober, J. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Garching bei München (Germany); Terzolo, L. [National Fusion Research Institute, Daejeon (Korea, Republic of); Zohm, H. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Garching bei München (Germany)

2014-06-15

A simulation is performed for feedback stabilization of neoclassical tearing mode (NTM) by electron cyclotron current drive (ECCD) for KSTAR in preparation for experiments. An integrated numerical system is constructed by coupling plasma transport, NTM stability, and heating and current drive modules and applied to a KSTAR plasma by assuming similar experimental conditions as ASDEX Upgrade to predict NTM behaviors in KSTAR. System identification is made with database produced by predictive simulations with this integrated numerical system so that three plasma response models are extracted which describe the relation between the EC poloidal launcher angle and the island width in KSTAR. Among them, the P1DI model exhibiting the highest fit accuracy is selected for designing a feedback controller based on the classical Proportional–Integral–Derivative (PID) concept. The controller is coupled with the integrated numerical system and applied to a simulation of NTM stabilization. It is observed that the controller can search and fully stabilize the mode even though the poloidal launch angle is misaligned with the island initially.

High recurrence rate of lymphadenitis due to nontuberculous mycobacteria and its association with concurrent Salmonella infection in Taiwan.

Science.gov (United States)

Hsiao, Cheng-Hsiang; Lai, Chih-Cheng; Hsueh, Po-Ren

2014-06-01

The objective of this study is to investigate the clinical characteristics of lymphadenitis due to nontuberculous mycobacteria (NTM) in Taiwan. We retrospectively reviewed the medical records of all patients who presented to the National Taiwan University Hospital with culture-positive NTM lymphadenitis during the period 2000-2010. Patients with concurrent extranodal involvement were excluded. From 2000 to 2010, 15 patients with lymphadenitis caused by nontuberculous mycobacteria were identified. Most patients (80%, n = 12) were infected with rapidly growing mycobacteria. Mycobacterium abscessus was the most common infective species (n = 8). Recurrence of infection involving multiple organs occurred 2-7 years after the completion of treatment in 11 (73%) patients. Five (33.3%) patients had concurrent Salmonella infections (4 patients with bacteremia and 1 patient with empyema thoracis) during the course of the disease. In Taiwanese patients, we found a high recurrence rate of NTM lymphadenitis that was closely associated with Salmonella infections. We also noted that the clinical and epidemiological manifestations of NTM lymphadenitis in Taiwan differed from their manifestations in western countries. Copyright © 2012. Published by Elsevier B.V.

Valitsemine, riskijuhtimine ja õigusnormide järgimine kui tervik süsteem / Karin Rätsep

Index Scriptorium Estoniae

Rätsep, Karin

2010-01-01

Ajakirja The Economist poolt 2009. aasta septembris läbiviidud üleilmse uuringu valitsemise, riskijuhtimise ja õigusnormide järgimise terviksüsteemidele hinnangu andmiseks. Uuringu olulisemad järeldused. KPMG poolt väljatöötatud valitsemise, riskijuhtimise ja õigusnormide järgimise raamistikust. Skeem

Kas arhitektuuripoliitika on poliitika või arhitektuur? / Tõnu Laigu

Index Scriptorium Estoniae

Laigu, Tõnu

2003-01-01

Arhitektuurinõukogu (esimees V. Kaasik) poolt välja töötatud arhitektuuripoliitika kiideti heaks Vabariigi Valitsuse poolt 22. X 2002. a. Eesti arhitektuuripoliitika tegevuskava väljatöötamiseks moodustati 23. XII 2002. a. komisjon, esimeheks T. Laigu. Arhitektuurialasest tegevuskavast, arhitektuuripoliitika teostumise eest vastutajad

Requirements on localized current drive for the suppression of neoclassical tearing modes

NARCIS (Netherlands)

Bertelli, N.; De Lazzari, D.; Westerhof, E.

2011-01-01

A heuristic criterion for the full suppression of an NTM was formulated as eta(NTM) = j(CD,max)/j(BS) >= 1.2 (Zohm et al 2005 J. Phys. Conf. Ser. 25 234), where j(CD,max) is the maximum in the driven current density profile applied to stabilize the mode and j(BS) is the local bootstrap current

Nietrzymanie moczu a czynniki ryzyka i jakość życia kobiet w Zakładzie Opiekuńczo-Leczniczym w Kielcach

Directory of Open Access Journals (Sweden)

Sławomir Dutkiewicz

2011-12-01

Full Text Available Wstęp: Jednym z najpoważniejszych problemów zdrowotnych jest nietrzymanie moczu (NTM. Częściej dotyczyon kobiet i dotyka ok. 3 mln kobiet rocznie. Cel pracy: Celem pracy była ocena czynników ryzyka NTM i wpływu tej dolegliwości na jakość życia kobietw Zakładzie Opiekuńczo-Leczniczym w Kielcach. Materiał i metody: Badano 60 kobiet po 50. r.ż. z NTM [w większości (76,7% badanych 71.–90. r.ż.]. Wyniki: U badanych 60 (100% kobiet z NTM współwystępowały nadciśnienie tętnicze ze względną niewydolnościąukładu krążenia, oddechowego, również ruchowego, a u 46 (77% kobiet także choroby przewlekłe,jak: cukrzyca, stwardnienie rozsiane, choroba Alzheimera, udar mózgu, depresja. Stwierdzono, iż na NTM u tychkobiet nie wpłynęły czynniki: wykształcenie i rodzaj pracy. Występowanie NTM korelowało u badanych kobietz powtarzającymi się zakażeniami moczu, które istotnie zależały od wieku badanych (p = 0,05 oraz od przyjmowanychleków moczopędnych, antydepresyjnych, przeciw nadciśnieniu tętniczemu. Wykazano także zależnośćod miejsca zamieszkania. Stwierdzono też występowanie NTM u badanych kobiet, które w przeszłości miałyzabiegi operacyjne na narządach okolicy miednicy mniejszej, a także rodziły więcej niż cztery razy. Wnioski: 1. U badanych kobiet po 70. r.ż. stwierdzono częstsze w porównaniu z młodszymi występowaniedysurii, naglących parć na mocz i nawrotów zakażeń moczu. 2. Nietrzymanie moczu u badanych wiązało sięz wieloma czynnikami ryzyka predysponującymi, promującymi oraz urazowymi. 3. Nietrzymanie moczu znaczniepogorszyło jakość życia u wszystkich badanych kobiet.

Recent RF Experiments and Application of RF Waves to Real-Time Control of Safety Factor Profile in JT-60U

International Nuclear Information System (INIS)

Suzuki, T.; Isayama, A.; Ide, S.; Fujita, T.; Oikawa, T.; Sakata, S.; Sueoka, M.; Hosoyama, H.; Seki, M.

2005-01-01

Two topics of applications of RF waves to current profile control in JT-60U are presented; application of lower-hybrid (LH) waves to safety factor profile control and electron cyclotron (EC) waves to neo-classical tearing mode (NTM) control. A real-time control system of safety factor (q) profile was developed. This system, for the first time, enables 1) real time evaluation of q profile using local magnetic pitch angle measurement by motional Stark effect (MSE) diagnostic and 2) control of current drive (CD) location (ρCD) by controlling the parallel refractive index N parallel of LH waves through control of phase difference (Δφ) of LH waves between multi-junction launcher modules. The method for real-time q profile evaluation was newly developed, without time-consuming reconstruction of equilibrium, so that the method requires less computational time. Safety factor profile by the real-time calculation agrees well with that by equilibrium reconstruction with MSE. The control system controls ρCD through Δφ in such a way to decrease the largest residual between the real-time evaluated q profile q(r) and its reference profile qref(r). The real-time control system was applied to a positive shear plasma (q(0)∼1). The reference q profile was set to monotonic positive shear profile having qref(0)=1.3. The real-time q profile approached to the qref(r) during application of real-time control, and was sustained for 3s, which was limited by the duration of the injected LH power. Temporal evolution of current profile was consistent with relaxation of inductive electric field induced by theoretical LH driven current. An m/n=3/2 NTM that appeared at βN∼3 was completely stabilized by ECCD applied to a fully-developed NTM. Precise ECCD at NTM island was essential for the stabilization. ECCD that was applied to resonant rational surface (q=3/2) before an NTM onset suppressed appearance of NTM. In order to keep NTM intensity below a level, ECCD before the mode onset was

Efficacy of calcium hypochlorite and ultraviolet irradiation against Mycobacterium fortuitum and Mycobacterium marinum

Directory of Open Access Journals (Sweden)

E A Roshani Edirisinghe

2017-01-01

Full Text Available Background: Nontuberculous mycobacteria (NTM cause opportunistic infections with increasing frequency in immunocompromised humans. Water is one of the natural sources for transmission of NTM and plays a major role in the epidemiology of NTM infections. This study evaluated the efficacy of calcium hypochlorite and ultraviolet irradiation (UV to eliminate potentially zoonotic NTM species such as M. marinum and M. fortuitum. Materials and Methods: Bacterial suspensions containing1-4 × 105 CFU/ml were exposed to 5, 50, 100, 1,000 and 10,000 mg/L of Ca (OCl2for 1, 5, 10, 15, 20, 30 and 60 minutes, and 6,000 μW/cm2 UV dose for 5, 10, 20, 30, 60 and 120 seconds. Results: Of the two methods tested, UV irradiation was more effective than chlorine in achieving three log reduction in viable bacterial count (UV dose 6,000 μW/cm2, exposure time 60 S as well as in eliminating the organisms (UV dose 17,000 μW/cm2, exposure time: 30 S. When 10,000 mg/L of chlorine was used, 10 and 20 min contact times were required to achieve three log inactivation and complete elimination of M. fortuitum respectively. Conclusion: Our study suggest that initial disinfection of water by chlorine at the water treatment plant followed by UV irradiation at the household level would minimise the spread of NTM to the susceptible population via drinking water.

Leedu Helsingi Grupp. Kohtumine 30 aastat hiljem / Mart Niklus

Index Scriptorium Estoniae

Niklus, Mart-Olav, 1934-

2007-01-01

9.-10. jaanuarini toimus Vilniuses kaks Leedu Helsingi Grupi asutamise 30. aastapäevale pühendatud konverentsi: Leedu Vabariigi Seimi poolt kokku kutsutud rahvusvaheline konverents ning Leedu Inimõiguste Assotsiatsiooni ja perekond Venclova memoriaalmuuseumi poolt korraldatud konverents "Leedu Helsingi Grupp. Kohtumine 30 aastat hiljem". Leedu Helsingi Grupist. Läti Okupatsioonimuuseumist

Source-case investigation of Mycobacterium wolinskyi cardiac surgical site infection.

Science.gov (United States)

Dupont, C; Terru, D; Aguilhon, S; Frapier, J-M; Paquis, M-P; Morquin, D; Lamy, B; Godreuil, S; Parer, S; Lotthé, A; Jumas-Bilak, E; Romano-Bertrand, S

2016-07-01

The non-tuberculous mycobacteria (NTM) Mycobacterium wolinskyi caused bacteraemia and massive colonization of an aortic prosthesis in a patient 16 days after cardiac surgery, necessitating repeat surgery and targeted antimicrobial chemotherapy. The infection control team investigated the source and conditions of infection. Peri-operative management of the patient complied with recommendations. The environmental investigation showed that although M. wolinskyi was not recovered, diverse NTM species were present in water from point-of-use taps and heater-cooler units for extracorporeal circulation. This case and increasing evidence of emerging NTM infections in cardiac surgery led to the implementation of infection control procedures in cardiac surgery wards. Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Eesti Vabariigi presidendi hr. Arnold Rüütli kõne / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold, 1928-

2002-01-01

Ilmunud ka: ; Proceedings of the 8th International conference Estonia and the European Union : Estonia on its way to a changing Europe : October 31-November 2, 2001. - Tallinn. Eesti liitumine ELiga on ühelt poolt ajaloolise õigluse taastumine, teiselt poolt on see aga loominguline väljakutse Eesti rahvale ja riigile, leiab autor

Projekteerimisturul optimism jätkub / Lauri Leet

Index Scriptorium Estoniae

Leet, Lauri

2008-01-01

Ilmunud ka: Stroitel nr. 1 lk. 12-15. Eesti Projekteerimisbüroode Liidu poolt tellitud ja Eesti Konjunktuuriinstituudi poolt läbi viidud uuringust projekteerimisturu olukorra kohta. Tabel: Arhitekti- ja inseneritegevuste areng 2000-2005. Diagrammid: Arhitekti- ja inseneritegevused Eestis; Ettevõtete projekteerimiskäibe kasvu prognoosid ettevõtete hinnangul; Projekteerimisturu käive

Töötajate varaline vastutus : [bakalaureusetöö] / Karin Lehari ; Tartu Ülikool, õigusteaduskond ; juhendaja: Merle Muda

Index Scriptorium Estoniae

Lehari, Karin

1999-01-01

Kahju tekitamisest tulenev kahju hüvitamine, töötaja poolt tekitatud kahju hüvitamise tingimused - varalise kahju olemasolu, töötaja teo õigusvastasus, põhjuslik seos, süü ja süü vormid, tööandja vastutus töötaja poolt kolmandatele isikutele tekitatud kahju eest

Eluohtlik töö: globaalne üleskutse ajakirjanike turvalisuse kaitseks

Index Scriptorium Estoniae

Spindelegger, Michael

2012-01-01

Austria Vabariigi asekantsleri ja välisministri Michael Spindeleggeri ning Rahvusvahelise Pressiinstituudi (IPI) tegevdirektori Alison Bethel McKenzie ühine kommentaar selle aasta septembris ÜRO Inimõiguste Nõukogu poolt vastu võetud resolutsioonile ajakirjanike turvalisuse kohta ning ÜRO agentuuride juhtide koordinatsiooninõukogu poolt vastu võetud ajakirjanike turvalisust puudutavast tegevusplaanist

Tomography high Resolution CT findings of nontuberculous mycobacterial pulmonary disease: Comparison between the first treatment and the re treatment group

Energy Technology Data Exchange (ETDEWEB)

Gwak, Soon Hyuk; Cho, Bum Sang; Jeon, Min Hee; Kim, Eun Young; Kang, Min Ho; Yi, Kyung Sik; Lee, Seung Young; Kim, Sung Jin; Lee, Ki Man [Chungbuk National Univ., Cheongju, (Korea, Republic of)

2012-06-15

To analyze and compare the thin section CT findings of first and re treatment nontuberculous mycobacterial (NTM) pulmonary disease. Between January 2005 and April 2010, 121 patients with positive sputum culture for NTM were recruited. We included only 32 patients underwent high resolution chest CT and were confirmed by American Thoracic Society criteria NTM pulmonary infection (first treatment 15, re treatment 17 patients). CT images of 32 patients were reviewed retrospectively. We evaluated the frequency and laterality of the followings; nodule, increased density, bronchial change, parenchymal change. The significantly frequent CT findings of the re treatment NTM group were well defined nodules (retreatment 82.4%, first treatment 33.3%, p = 0.00), consolidations (retreatment 88.2%, first treatment 53.3%, p = 0.03), bronchial changes (bronchiectasis; retreatment 100%, first treatment 66.6%, p = 0.01, bronchial narrowing; retreatment 23.5%, first treatment 0%, p = 0.04 and mucoid impaction; retreatment-58.8%, first treatment-20.0%, p = 0.03) and atelectasis with bronchiectasis (retreatment-88.2%, first treatment 26.7%, p = 0.00). However, most of the evaluated thin section CT findings, such as centrilobular and ill defined nodules, lobular, segmental and subpleural consolidations, ground glass attenuation, bronchial wall thickening, cavities, pleural lesions, fibrotic band, emphysema and laterality of lesions, have not shown significant differences between first treatment and the re treatment group. Thin section CT findings of well defined nodules, consolidations, bronchial changes (bronchiectasis, bronchial narrowing and mucoid impaction) and atelectasis with bronchiectasis are highly suggestive of re treatment NTM pulmonary disease.

Utility of gastric aspirates for diagnosing tuberculosis in children in a low prevalence area: predictors of positive cultures and significance of non-tuberculous mycobacteria.

Science.gov (United States)

Kordy, Faisal; Richardson, Susan E; Stephens, Derek; Lam, Ray; Jamieson, Frances; Kitai, Ian

2015-01-01

In countries with low rates of tuberculosis (TB), yields of gastric aspirates (GAs) for Mycobacterium tuberculosis (MTB) culture are low. The significance of non-tuberculous mycobacteria (NTM) isolated from GA is uncertain. We reviewed clinical, microbiologic and radiologic data for children who underwent GA between 1999 and 2011 at Sick Kids, Toronto. Radiologic features of cases were compared with those of age matched controls. 785 GAs were obtained from 285 patients of whom 20 (7%) had positive MTB cultures: in 15 patients the GA was the only positive culture for MTB. Of 15 culture-positive patients who underwent exactly 3 GAs, MTB was isolated from the first lavage in 10 (67%), only from the second in 3 (20%) and only from the third in 2 (13%). On univariate analysis, miliary disease and intrathoracic lymphadenopathy were associated with a positive GA MTB culture. On multiple conditional logistic regression analysis, adenopathy remained significant (OR 10.2 [95% CI 2.0-51.4] p =0.005). Twelve patients had NTM isolated, most commonly M. avium complex: none had evidence of invasive NTM disease during a median duration of 12 months of follow-up. Causal pathogens different from the GA NTM culture were isolated from biopsies or bronchoalveolar lavage in 3. GAs continue to be important for TB diagnosis in children. Three GAs have a yield better than 1. Those with miliary or disseminated TB and intrathoracic lymphadenopathy have highest yields. NTM isolates from GA are likely unimportant and can be clinically misleading.

Neoclassical tearing modes on ASDEX Upgrade: Improved scaling laws, high confinement at high βN and new stabilization experiments

International Nuclear Information System (INIS)

Guenter, S.; Gude, A.; Igochine, V.; Maraschek, M.; Sips, A.C.C.; Zohm, H.; Gantenbein, G.; Sauter, O.

2003-01-01

In this paper recent results on the physics of neoclassical tearing modes (NTMs) achieved on ASDEX Upgrade are reported. A scaling law for NTM decay has been found, showing that the minimum local bootstrap current density required for mode growth is proportional to the ion gyro radius. As this scaling law does not depend on the seed island size, and thus on the background MHD activity, it is more reliable than previously derived scaling laws for the NTM onset. Furthermore, the recently reported Frequently Interrupted Regime (FIR) is discussed. In this new regime (m,n) NTMs are characterized by frequent amplitude drops caused by interaction with (m+1,n+1) background MHD activity. Due to the resulting reduced time averaged island size this leads to lower confinement degradation compared to that caused by the usual NTMs. As shown here, the transition into this regime can actively be triggered by lowering the magnetic shear at the q=(m+1)/=(n+1) rational surface. Further investigations regard mechanisms to increase the β N value for NTM onset such as plasma shaping, seed island size and density profile control. Using these studies, a scenario with high β N (β N = 3:5) at high density (n/n GW = 0.83) and confinement (H 98(y,2) = 1.2) has been developed. Moreover, this scenario is characterized by type II ELM activity and thus by moderate heat load to the target plates. Finally, new NTM stabilization experiments are reported, demonstrating an increase in β N after NTM stabilization. (author)

Linlased saavad valida Tallinna uut logo / Askur Alas

Index Scriptorium Estoniae

Alas, Askur, 1973-

2005-01-01

Tallinna logo konkursist. Rahvusvahelise žürii poolt valitud 10 finalisti pluss Aavo Ermeli poolt 2003. a. kavandatud logo on hindamiseks veebilehel logo.tallinn.ee. Ermeli logo "mineoletulevik" on praegu kasutusel. Finalistidele annavad hinnangu linnavalitsuse liikmed, rahvusvaheline žürii ja tallinlased SMS-hääletuse teel. Žürii koosseis. Lisatud 11 kavandit

Sarri võttis Talleksiga taanlastelt Saksa Auto / Villy Paimets

Index Scriptorium Estoniae

Paimets, Villy, 1972-

2005-01-01

Andres Sarri poolt kontrollitav AS Talleks ostis Taani partnerilt Semler Holding välja 50-protsendilise osaluse AS-is Saksa Auto. Lisa: Viimastel aastatel eestlaste poolt välja ostetud ettevõtted. Diagramm: Saksa Auto tulemused paranesid mullu märgatavalt. Vt. samas: Sarri: me ei tee halbu tehinguid; Peeter Raidla. Tuleristsed 90ndate alguse võimuvõitlusest

Katoliku kiriku sotsiaalõpetusest ja poliitika eetilisest vastutusest / Philippe Jourdan

Index Scriptorium Estoniae

Jourdan, Philippe, 1960-

2005-01-01

Katoliku kiriku sotsiaaõpetuse eesmärk on määratleda, milline peab olema poliitika ja religiooni õige vahekord. Kui need vahekorrad ei ole ühiskonnas õigesti reguleeritud, võivad autori arvates mõjule pääseda kaks ühiskonda ning kirikut lõhestavat väärtendentsi, ühelt poolt klerikalism ja teiselt poolt sekularism

Huntington ja kartulikoored / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2008-01-01

Autor nendib, et poliitilistest mõttestampidest ja illusioonidest vabanemine nõuaks Eesti enesekaemuses kohati üsna drastilisi kontseptuaalseid inversioone. Neli olulisemat inversiooni: Lääne-Euroopa poolt vaadatuna on Eesti osa endisest Nõukogude Liidust, Eesti on riik rahvuse teenistuses, Eesti vene kogukonnas toimub omalaadne "kontra-etnogenees", vene kogukonna liidrid on asunud ära kasutama Euroopa Liidu poolt avatud võimalusi

Ameerika vajab kangelasi / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2007-01-01

Näitleja ja režissöör Clint Eastwood. Tema kaks viimast filmi on Teises Maailmasõjas USA-Jaapani Iwo Jima saarel peetud ebavõrdse lahingu teemal. USA poolt vaadatuna - "Meie isade lipud" ("Flags of Our Fathers"), Jaapani poolt - "Kirjad Iwo Jimalt" ("Letters From Iwo Jima") : Ameerika Ühendriigid 2006. Lisaks režissöörist "Eastwood ei kahetse midagi"

Kuidas valiti president 1996. aastal? / Rein Toomla

Index Scriptorium Estoniae

Toomla, Rein, 1951-

2002-01-01

Autor leiab 1996. aasta presidendivalimisi analüüsides, et oluliseks tuleb pidada seda, et valimised suudeti põhiseaduses ettenähtud korras läbi viia ning ei pidanud käivituma erakorraliste valimiste mehhanism. Tabelid: 1995. a. Riigikogu valimised; Riigikogu fraktsioonid 1996. a. suvel; Toetus presidendikandidaatidele; Presidendivalimised Riigikogus; Arvatavasti Lennart Meri poolt; Arvatavasti Arnold Rüütli poolt; Presidendivalimised Valimiskogus

Development of a One-Step Multiplex PCR Assay for Differential Detection of Major Mycobacterium Species.

Science.gov (United States)

Chae, Hansong; Han, Seung Jung; Kim, Su-Young; Ki, Chang-Seok; Huh, Hee Jae; Yong, Dongeun; Koh, Won-Jung; Shin, Sung Jae

2017-09-01

The prevalence of tuberculosis continues to be high, and nontuberculous mycobacterial (NTM) infection has also emerged worldwide. Moreover, differential and accurate identification of mycobacteria to the species or subspecies level is an unmet clinical need. Here, we developed a one-step multiplex PCR assay using whole-genome analysis and bioinformatics to identify novel molecular targets. The aims of this assay were to (i) discriminate between the Mycobacterium tuberculosis complex (MTBC) and NTM using rv0577 or RD750, (ii) differentiate M. tuberculosis ( M. tuberculosis ) from MTBC using RD9, (iii) selectively identify the widespread M. tuberculosis Beijing genotype by targeting mtbk_20680 , and (iv) simultaneously detect five clinically important NTM ( M. avium , M. intracellulare , M. abscessus , M. massiliense , and M. kansasii ) by targeting IS 1311 , DT1, mass_3210 , and mkan_rs12360 An initial evaluation of the multiplex PCR assay using reference strains demonstrated 100% specificity for the targeted Mycobacterium species. Analytical sensitivity ranged from 1 to 10 pg for extracted DNA and was 10 3 and 10 4 CFU for pure cultures and nonhomogenized artificial sputum cultures, respectively, of the targeted species. The accuracy of the multiplex PCR assay was further evaluated using 55 reference strains and 94 mycobacterial clinical isolates. Spoligotyping, multilocus sequence analysis, and a commercial real-time PCR assay were employed as standard assays to evaluate the multiplex PCR assay with clinical M. tuberculosis and NTM isolates. The PCR assay displayed 100% identification agreement with the standard assays. Our multiplex PCR assay is a simple, convenient, and reliable technique for differential identification of MTBC, M. tuberculosis , M. tuberculosis Beijing genotype, and major NTM species. Copyright © 2017 American Society for Microbiology.

Cutaneous non-tuberculous Mycobacterial infections: a clinical and histopathological study of 17 cases from Lebanon.

Science.gov (United States)

Abbas, O; Marrouch, N; Kattar, M M; Zeynoun, S; Kibbi, A G; Rached, R A; Araj, G F; Ghosn, S

2011-01-01

Only a few studies characterized cutaneous non-tuberculous Mycobacterium (NTM) infections in this region of the world. Objective  The aim of this study was to describe the epidemiological, clinical and histological findings of cutaneous NTM infections in Lebanon. Retrospective study of 17 patients (19 histological specimens) diagnosed with cutaneous NTM infections and confirmed by culture-based partial sequencing of the 16S rRNA gene at the American University of Beirut Medical Center between 2005 and 2008. Of 17 cases, 14 were caused by Mycobacterium marinum. All patients were immunocompetent except for one. Clinically, the most common presentation was multiple sporotrichoid lesions over an extremity (8/17). Many patients had peculiar presentations including bruise-like patches, herpetiform lesions, annular ulcerated plaques, symmetrical nodules over the buttocks and locally disseminated lesions with surrounding pale halo. Almost all patients cleared their infection on either minocycline or clarithromycin monotherapies. Histologically, a dermal small vessel proliferation with mixed inflammation (granulation tissue-like changes) was identified in 58% of specimens. The most common type of granulomatous inflammation was the suppurative (47%) followed by the tuberculoid (30%), sarcoidal (11%), and palisading (5%) types. Lichenoid granulomatous dermatitis was noted in 42% of cases. Special staining highlighted mycobacteria in only two specimens. The incidence of cutaneous NTM infections is high in our area. Many patients had peculiar clinical presentations. Our study is the second to report the common presence of granulation tissue-like changes as a good histological indicator of cutaneous NTM infections. Minocycline and clarithromycin remain the drugs of choice in our area. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay.

Science.gov (United States)

Sankar, Manimuthu Mani; Gopinath, Krishnamoorthy; Singla, Roopak; Singh, Sarman

2008-07-11

Non-tubercular mycobacteria (NTM) has not been given due attention till the recent epidemic of HIV. This has led to increasing interest of health care workers in their biology, epidemiology and drug resistance. However, timely detection and drug susceptibility profiling of NTM isolates are always difficult in resource poor settings like India. Furthermore, no standardized methodology or guidelines are available to reproduce the results with clinical concordance. To find an alternative and rapid method for performing the drug susceptibility assay in a resource limited settings like India, we intended to evaluate the utility of Tetrazolium microplate assay (TEMA) in comparison with proportion method for reporting the drug resistance in clinical isolates of NTM. A total of fifty-five NTM isolates were tested for susceptibility against Streptomycin, Rifampicin, Ethambutol, Ciprofloxacin, Ofloxacin, Azithromycin, and Clarithromycin by TEMA and the results were compared with agar proportion method (APM). Of the 55 isolates, 23 (41.8%) were sensitive to all the drugs and the remaining 32 (58.2%) were resistant to at least one drug. TEMA had very good concordance with APM except with minor discrepancies. Susceptibility results were obtained in the median of 5 to 9 days by TEMA. The NTM isolates were highly sensitive against Ofloxacin (98.18% sensitive) and Ciprofloxacin (90.09% sensitive). M. mucogenicum was sensitive only to Clarithromycin and resistant to all the other drugs tested. The concordance between TEMA and APM ranged between 96.4 - 100%. Tetrazolium Microplate Assay is a rapid and highly reproducible method. However, it must be performed only in tertiary level Mycobacteriology laboratories with proper bio-safety conditions.

Real time MHD mode control using ECCD in KSTAR: Plan and requirements

Energy Technology Data Exchange (ETDEWEB)

Joung, M.; Woo, M. H.; Jeong, J. H.; Hahn, S. H.; Yun, S. W.; Lee, W. R.; Bae, Y. S.; Oh, Y. K.; Kwak, J. G.; Yang, H. L. [National Fusion Research Institute, 52 Eoeun-dong, Yuseong-gu, Daejeon (Korea, Republic of); Namkung, W.; Park, H.; Cho, M. H. [Department of Physics, POSTECH, Hyoja-dong, Nam-gu, Pohang, Gyeongangbuk-do (Korea, Republic of); Kim, M. H.; Kim, K. J.; Na, Y. S. [Department of Nuclear Engineering, Seoul National University, Daehak-dong, Gwanak-gu, Seoul (Korea, Republic of); Hosea, J.; Ellis, R. [Princeton Plasma Physics Laboratory, Princeton (United States)

2014-02-12

For a high-performance, advanced tokamak mode in KSTAR, we have been developing a real-time control system of MHD modes such as sawtooth and Neo-classical Tearing Mode (NTM) by ECH/ECCD. The active feedback control loop will be also added to the mirror position and the real-time detection of the mode position. In this year, for the stabilization of NTM that is crucial to plasma performance we have implemented open-loop ECH antenna control system in KSTAR Plasma Control System (PCS) for ECH mirror movement during a single plasma discharge. KSTAR 170 GHz ECH launcher which was designed and fabricated by collaboration with PPPL and POSTECH has a final mirror of a poloidally and toroidally steerable mirror. The poloidal steering motion is only controlled in the real-time NTM control system and its maximum steering speed is 10 degree/sec by DC motor. However, the latency of the mirror control system and the return period of ECH antenna mirror angle are not fast because the existing launcher mirror control system is based on PLC which is connected to the KSTAR machine network through serial to LAN converter. In this paper, we present the design of real time NTM control system, ECH requirements, and the upgrade plan.

Non-perturbative measurement of cross-field thermal diffusivity reduction at the O-point of 2/1 neoclassical tearing mode islands in the DIII-D tokamak

Energy Technology Data Exchange (ETDEWEB)

Bardóczi, L.; Rhodes, T. L.; Carter, T. A.; Crocker, N. A.; Peebles, W. A. [University of California Los Angeles, Los Angeles, California 90095 (United States); Grierson, B. A. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

2016-05-15

Neoclassical tearing modes (NTMs) often lead to the decrease of plasma performance and can lead to disruptions, which makes them a major impediment in the development of operating scenarios in present toroidal fusion devices. Recent gyrokinetic simulations predict a decrease of plasma turbulence and cross-field transport at the O-point of the islands, which in turn affects the NTM dynamics. In this paper, a heat transport model of magnetic islands employing spatially non-uniform cross-field thermal diffusivity (χ{sub ⊥}) is presented. This model is used to derive χ{sub ⊥} at the O-point from electron temperature data measured across 2/1 NTM islands in DIII-D. It was found that χ{sub ⊥} at the O-point is 1 to 2 orders of magnitude smaller than the background plasma transport, in qualitative agreement with gyrokinetic predictions. As the anomalously large values of χ{sub ⊥} are often attributed to turbulence driven transport, the reduction of the O-point χ{sub ⊥} is consistent with turbulence reduction found in recent experiments. Finally, the implication of reduced χ{sub ⊥} at the O-point on NTM dynamics was investigated using the modified Rutherford equation that predicts a significant effect of reduced χ{sub ⊥} at the O-point on NTM saturation.

Linnakeskkonna agenda : Stockholm - poolt ja vastu / Jaak Poom

Index Scriptorium Estoniae

Poom, Jaak

2004-01-01

Rootsi valitsuse moodustatud linnaplaneerimise ja -ehitamise komitee andis 2003. a. välja "Linnakeskkonna agenda", mis võtab kokku linna planeerimise positiivse kogemuse. Stadsmiljöradet'i linnaehituspõhimõtted. Linnaarenduspoliitikast, J. Poom agenda soovitustest, linnaplaneeringust eesrindlikult planeeritud Stocholmi linnaosa näite varal

Rare Case of Non Tuberculous Mycobacterial: A Diagnostic dilemma

LENUS (Irish Health Repository)

Marathe, N

2017-02-01

Non-Tuberculous Mycobacterial (NTM) infections occur in HIV-negative patients with or without underlying lung disease. It is generally felt that these organisms are acquired from the environment. Unlike tuberculosis, there are no convincing data demonstrating human-to-human OR animal-to-human transmission of NTM. We report a case of NTM infection in a 38 year old patient with underlying emphysematous lung disease. The case highlights the diagnostic dilemma which occurs when persistent sputum Acid- Fast Bacilli (AFB) smears are positive, but Nucleic acid amplification test is negative. To aid the diagnosis and rule out Pulmonary Tuberculosis as the other differential diagnosis, we applied American Thoracic Society\\/Infectious Disease Society of America (ATS\\/IDSA) guidelines & recommendations1. The decision to treat was taken on basis of CT findings, clinical, microbiologic criteria and expert consultation with Microbiology department at Waterford.

Assessment of U.S. and Coalition Efforts to Develop Leaders in the Afghan National Army

Science.gov (United States)

2013-06-24

Literacy remains an enabler for soldier and NCO development, and creates a more discerning citizen for Afghan society . Despite challenges, the...level and economic capacity of the society as a whole. In terms of its importance to professional development, both ANA and NTM-A senior...available in the account, nor if the account is actuarially sound. The NTM-A/CSTC-A lnsp.ector General continues to work with the MoD to resolve a

Ministri nõunik kui poliitilise missiooniga ametnik / Maria Keris, Jako Salla

Index Scriptorium Estoniae

Keris, Maria

2006-01-01

Ministri nõuniku roll ja positsioon Eesti avalikus teenistuses ja poliitikas. Kahes Eesti ministeeriumis 2005. aastal tehtud juhtumiuuringu analüüs. Ministri nõuniku roll ja staatus Eesti administratiivsüsteemis pole veel kinnistunud ning tõenäoliselt kujunebki sellest ametikoht, mille täitmine sõltub ühelt poolt vajadusest ja ministri soovidest ning teiselt poolt ministeeriumi töökorraldusest ja valdkonna spetsiifikast

Increasing Recovery of Nontuberculous Mycobacteria from Respiratory Specimens over a 10-Year Period in a Tertiary Referral Hospital in South Korea

OpenAIRE

Koh, Won-Jung; Chang, Boksoon; Jeong, Byeong-Ho; Jeon, Kyeongman; Kim, Su-Young; Lee, Nam Yong; Ki, Chang-Seok; Kwon, O Jung

2013-01-01

Background The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Methods We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. Results During the study pe...

Structured Memory for Neural Turing Machines

OpenAIRE

Zhang, Wei; Yu, Yang; Zhou, Bowen

2015-01-01

Neural Turing Machines (NTM) contain memory component that simulates "working memory" in the brain to store and retrieve information to ease simple algorithms learning. So far, only linearly organized memory is proposed, and during experiments, we observed that the model does not always converge, and overfits easily when handling certain tasks. We think memory component is key to some faulty behaviors of NTM, and better organization of memory component could help fight those problems. In this...

Molecular identification of nontuberculous mycobacteria isolated from pyogenic bovine tissues in South Darfur State and Alsabalouga slaughterhouse at Omdurman area, Sudan

Directory of Open Access Journals (Sweden)

A.E. El Tigani-Asil

2014-02-01

Full Text Available This study identified nontuberculous mycobacteria (NTM recovered from bovine pyogenic affections obtained at necropsy using the molecular target 16S-23S rDNA internal transcribed spacer region. Postmortem inspection of cattle was conducted at South Darfur State abattoirs and Alsabalouga Slaughterhouse at Omdurman area during 2007-2009. Specimens were examined for the presence of acid fast bacteria (AFB using microscopic and standard culturing techniques. AFB were identified phenotypically and confirmed by 16S-23S rDNA ITS. Fifty nine NTM were recovered and confirmed as acid fast filaments out of 165 positive AFB specimens, of which 52 isolates were identified as bovine farcy causative agents, while 7 cultures were excluded due to drying. 16S-23S rDNA ITS of NTM revealed three different amplicons 500 bp. (32 isolates, 550 bp. (2 isolates and 600 bp. (14 isolates. Four isolates were contaminated.

Molecular identification of nontuberculous mycobacteria isolated from pyogenic bovine tissues in South Darfur State and Alsabalouga slaughterhouse at Omdurman area, Sudan.

Science.gov (United States)

Tigani-Asil, A E El; Sanousi, S M El; Aljameel, M A; Beir, H El; Adam, A; Abdallatif, M M; Hamid, M E

2014-01-01

This study identified nontuberculous mycobacteria (NTM) recovered from bovine pyogenic affections obtained at necropsy using the molecular target 16S-23S rDNA internal transcribed spacer region. Postmortem inspection of cattle was conducted at South Darfur State abattoirs and Alsabalouga Slaughterhouse at Omdurman area during 2007-2009. Specimens were examined for the presence of acid fast bacteria (AFB) using microscopic and standard culturing techniques. AFB were identified phenotypically and confirmed by 16S-23S rDNA ITS. Fifty nine NTM were recovered and confirmed as acid fast filaments out of 165 positive AFB specimens, of which 52 isolates were identified as bovine farcy causative agents, while 7 cultures were excluded due to drying. 16S-23S rDNA ITS of NTM revealed three different amplicons 500 bp. (32) isolates, 550 bp. (2) isolates and 600 bp. (14) isolates. Four isolates were contaminated.

Non-tuberculous mycobacteria and microbial populations in drinking water distribution systems

Directory of Open Access Journals (Sweden)

Rossella Briancesco

2010-01-01

Full Text Available Data on the occurrence of non-tuberculous mycobacteria (NTM, in parallel with those obtained for bacterial indicators and amoebae, are presented with the aim to collect information on the spread of NTM in drinking water distribution systems in Italy. Samples were collected from taps of hospitals and households in Central and Southern Italy. The concentration values obtained for the more traditional microbial parameters complied with the mandatory requirements for drinking water. Conversely, moderate-to-high microbial loads (till 300 CFU/L were observed for the NTM. Positive samples were obtained from 62% of the investigated water samples. Analogous results were observed for amoebae showing a higher percentage of positive samples (76%. In terms of public health, the presence of mycobacteria in water distribution systems may represent a potential risk especially for vulnerable people such as children, the elderly or immunocompromised individuals.

Detection and differentiation of Mycobacterium tuberculosis and nontuberculous mycobacterial isolates by real-time PCR.

Science.gov (United States)

Shrestha, Nabin K; Tuohy, Marion J; Hall, Gerri S; Reischl, Udo; Gordon, Steven M; Procop, Gary W

2003-11-01

Mycobacteria cause a variety of illnesses that differ in severity and public health implications. The differentiation of Mycobacterium tuberculosis from nontuberculous mycobacteria (NTM) is of primary importance for infection control and choice of antimicrobial therapy. Despite advances in molecular diagnostics, the ability to rapidly diagnose M. tuberculosis infections by PCR is still inadequate, largely because of the possibility of false-negative reactions. We designed and validated a real-time PCR for mycobacteria by using the LightCycler system with 18 reference strains and 168 clinical mycobacterial isolates. All clinically significant mycobacteria were detected; the mean melting temperatures (with 99.9% confidence intervals [99.9% CI] in parentheses) for the different mycobacteria were as follows: M. tuberculosis, 64.35 degrees C (63.27 to 65.42 degrees C); M. kansasii, 59.20 degrees C (58.07 to 60.33 degrees C); M. avium, 57.82 degrees C (57.05 to 58.60 degrees C); M. intracellulare, 54.46 degrees C (53.69 to 55.23 degrees C); M. marinum, 58.91 degrees C (58.28 to 59.55 degrees C); rapidly growing mycobacteria, 53.09 degrees C (50.97 to 55.20 degrees C) or 43.19 degrees C (42.19 to 44.49 degrees C). This real-time PCR assay with melting curve analysis consistently accurately detected and differentiated M. tuberculosis from NTM. Detection of an NTM helps ensure that the negative result for M. tuberculosis is a true negative. The specific melting temperature also provides a suggestion of the identity of the NTM present, when the most commonly encountered mycobacterial species are considered. In a parallel comparison, both the LightCycler assay and the COBAS Amplicor M. tuberculosis assay correctly categorized 48 of 50 specimens that were proven by culture to contain M. tuberculosis, and the LightCycler assay correctly characterized 3 of 3 specimens that contained NTM.

Long sustainment of quasi-steady-state high βp H mode discharges in JT-60U

International Nuclear Information System (INIS)

Isayama, A.; Kamada, Y.; Ozeki, T.; Ide, S.; Fujita, T.; Oikawa, T.; Suzuki, T.; Neyatani, Y.; Isei, N.; Hamamatsu, K.; Ikeda, Y.; Takahashi, K.; Kajiwara, K.

2001-01-01

Quasi-steady-state high β p H mode discharges performed by suppressing neoclassical tearing modes (NTMs) are described. Two operational scenarios have been developed for long sustainment of the high β p H mode discharge: NTM suppression by profile optimization, and NTM stabilization by local electron cyclotron current drive (ECCD)/electron cyclotron heating (ECH) at the magnetic island. Through optimization of pressure and safety factor profiles, a high β p H mode plasma with H 89PL = 2.8, HH y,2 = 1.4, β p ∼ 2.0 and β N ∼ 2.5 has been sustained for 1.3 s at small values of collisionality ν e* and ion Larmor radius ρ i* without destabilizing the NTMs. Characteristics of the NTMs destabilized in the region with central safety factor above unity are investigated. The relation between the beta value at the mode onset β N on and that at the mode disappearance β N off can be described as β N off /β N on =0.05-0.4, which shows the existence of hysteresis. The value of β N /ρ i* at the onset of an m/n = 3/2 NTM has a collisionality dependence, which is empirically given by β N /ρ i* ∝ ν e* 0.36 . However, the profile effects such as the relative shapes of pressure and safety factor profiles are equally important. The onset condition seems to be affected by the strength of the pressure gradient at the mode rational surface. Stabilization of the NTM by local ECCD/ECH at the magnetic island has been attempted. A 3/2 NTM has been completely stabilized by EC wave injection of 1.6 MW. (author)

Exit Site Infection due to Mycobacterium chelonae in an Elderly Patient on Peritoneal Dialysis

Directory of Open Access Journals (Sweden)

Arata Hibi

2018-01-01

Full Text Available Nontuberculous mycobacteria (NTM are rarely isolated from peritoneal dialysis (PD-associated catheter infections. However, NTM infection is usually difficult to treat and leads to catheter loss. Prompt diagnosis is essential for appropriate treatment. A 70-year-old Japanese man who had been on PD for 2 years and with a medical history of 2 episodes of exit site infections (ESIs due to methicillin-resistant Staphylococcus aureus was admitted to the hospital due to suspected ESI recurrence. However, Gram staining of the pus revealed no gram-positive cocci. Instead, weakly stained gram-positive rods were observed after 7 days of incubation, which were also positive for acid-fast staining. Rapidly growing NTM Mycobacterium chelonae was isolated on day 14. Despite administering a combination antibiotic therapy, ESI could not be controlled, and catheter removal surgery was performed on day 21. Although PD was discontinued temporarily, the patient did not require hemodialysis, without any uremic symptoms. The catheter was reinserted on day 48, and PD was reinitiated on day 61. The patient was discharged on day 65. Antibiotic therapy was continued for 3 months after discharge, with no indications of recurrent infections observed. It is important to consider the risk of NTM infections in patients on PD. Acid-fast staining could be a key test for prompt diagnosis and provision of an appropriate treatment.

Reduction of Acid-Fast and Non-Acid-Fast Bacteria by Point of Use Coagulation-Flocculation-Disinfection

Directory of Open Access Journals (Sweden)

Lisa M. Casanova

2015-11-01

Full Text Available Point of use (POU household water treatment is increasingly being adopted as a solution for access to safe water. Non-tuberculous Mycobacteria (NTM are found in water, but there is little research on whether NTM survive POU treatment. Mycobacteria may be removed by multi-barrier treatment systems that combine processes such as coagulation, settling and disinfection. This work evaluated removal of a non-tuberculous Mycobacterium (Mycobaterium terrae and a Gram-negative non-acid-fast environmental bacterium (Aeromonas hydrophila by combined coagulation-flocculation disinfection POU treatment. Aeromonas hydrophila showed 7.7 log10 reduction in demand free buffer, 6.8 log10 in natural surface water, and 4 log10 reduction in fecally contaminated surface water. Turbidity after treatment was <1 NTU. There was almost no reduction in levels of viable M. terrae by coagulant-flocculant-disinfectant in natural water after 30 minutes. The lack of Mycobacteria reduction was similar for both combined coagulant-flocculant-disinfectant and hypochlorite alone. A POU coagulant-flocculant-disinfectant treatment effectively reduced A. hydrophila from natural surface waters but not Mycobacteria. These results reinforce previous findings that POU coagulation-flocculation-disinfection is effective against gram-negative enteric bacteria. POU treatment and safe storage interventions may need to take into account risks from viable NTM in treated stored water and consider alternative treatment processes to achieve NTM reductions.

Multisite Infection with Mycobacterium abscessus after Replacement of Breast Implants and Gluteal Lipofilling.

Science.gov (United States)

Rüegg, Eva; Cheretakis, Alexandre; Modarressi, Ali; Harbarth, Stephan; Pittet-Cuénod, Brigitte

2015-01-01

Introduction. Medical tourism for aesthetic surgery is popular. Nontuberculous mycobacteria (NTM) occasionally cause surgical-site infections. As NTM grow in biofilms, implantations of foreign bodies are at risk. Due to late manifestation, infections occur when patients are back home, where they must be managed properly. Case Report. A 39-year-old healthy female was referred for acute infection of the right gluteal area. Five months before, she had breast implants replacement, abdominal liposuction, and gluteal lipofilling in Mexico. Three months postoperatively, implants were removed for NTM-infection in Switzerland. Adequate antibiotic treatment was stopped after seven days for drug-related hepatitis. At entrance, gluteal puncture for bacterial analysis was performed. MRI showed large subcutaneous collection. Debridement under general anaesthesia was followed by open wound management. Total antibiotic treatment was 20 weeks. Methods. Bacterial analysis of periprosthetic and gluteal liquids included Gram-stain plus acid-fast stain, and aerobic, anaerobic and mycobacterial cultures.  Results. In periprosthetic fluid, Mycobacterium abscessus, Propionibacterium, and Staphylococcus epidermidis were identified. The same M. abscessus strain was found gluteally. The gluteal wound healed within six weeks. At ten months' follow-up, gluteal asymmetry persists for deep scarring. Conclusion. This case presents major complications of multisite aesthetic surgery. Surgical-site infections in context of medical tourism need appropriate bacteriological investigations, considering potential NTM-infections.

Nontuberculous mycobacteria infection after mesotherapy: preliminary report of 15 cases.

Science.gov (United States)

Sañudo, Alejandra; Vallejo, Fernando; Sierra, Martha; Hoyos, Juan G; Yepes, Sandra; Wolff, Juan Carlos; Correa, Luis A; Montealegre, Carlos; Navarro, Pilar; Bedoya, Elina; Sanclemente, Gloria

2007-06-01

Mesotherapy is an increasingly used technique which is currently causing several mycobacterial infections owing to contaminated substances being injected, and also to poor aseptic measures being held by nonprofessional practitioners. We collected 15 cases of nontuberculous mycobacteria (NTM) infection after mesotherapy in a 6-month period. All patients were female with ages ranging from 19 to 52 years; the main substances injected were procaine and lecithin, and the time between mesotherapy and the appearance of the lesions varied between 1 and 12 weeks. Clinical lesions were mostly nodules and abscesses, which were localized in the abdomen and buttocks in the majority of cases. The main patient complaint was local pain but some presented with systemic symptoms such as fever and malaise. Biopsies reported granulomatous chronic inflammation in the majority of cases. Skin cultures were positive for NTM and Mycobacterium chelonae. Mesotherapy not performed with quality controlled substances can be a predisposing factor for NTM infection.

Tokamak plasma transport simulation in the presence of neoclassical tearing modes

International Nuclear Information System (INIS)

Takahashi, Y.; Yamazaki, K.; Arimoto, H.; Shoji, T.; Garcia, J.

2008-01-01

For the prediction of the ITER plasmas, the effect of the neoclassical tearing mode (NTM) on the plasma confinement has been calculated using the 1.5-dimensional equilibrium and transport simulation code TOTAL. The time evolution of the NTM magnetic island has been analyzed using the modified Rutherford equation for a ITER normal shear plasma. The anomalous transport model used here is GLF23. The saturated magnetic island widths are w/a - 0.048 at 3/2 mode and w/a - 0.21 at 2/1 mode, and the reduction in fusion power output by NTM is 27% at the 3/2 mode, 82% at the 2/1 mode, and 89% at the 3/2 + 2/1 double mode. The stabilization effect of the electron cyclotron current drive (ECCD) with EC is also clarified. The threshold of ECCD power for the full stabilization is ∼10[MW] against the 3/2 mode, and ∼23[MW] against the 2/1 mode. (author)

Tallinna Lennujaama kauba- ja tolliterminaal. Lennujaama 2, Tallinn / Andres Põime

Index Scriptorium Estoniae

Põime, Andres

1998-01-01

Kaubateeninduskeskuse puhul on tegemist suure, plaanimõõtudes 36x102 meetrise metallkonstruktsioonis, sandwich tüüpi paneelidega kaetud laohoonega, kus ühelt poolt tuuakse tollitav kaup lennukitelt sisse ja teiselt poolt viiakse tollitud kaup välja. Peatöövõtja : Normanni Linnagrupi AS. Ehitaja : Merko. Peaprojekteerija : K-Projekt. Arhitektuurne lahendus : Stuudio 3. Arhitekt Andres Põime ; töögrupp Vivian Oruvee, Tiiu Raudsepp, Reet Põime. Projekt 1997-98, valmis 1998.

Presidents' green rhetoric at U.N. questioned / Joel Alas

Index Scriptorium Estoniae

Alas, Joel

2007-01-01

President Toomas Hendrik Ilves kõneles 24. septembril 2007 ÜRO peakorteris toimunud kliimakonverentsil, tehes seda Euroopa Liidu eesistujamaa Portugali palvel kogu Euroopa Liidu nimel. Erakonna Eestimaa Rohelised liider Marek Strandberg seab kahtluse alla mõnede president T.H. Ilvese poolt esitatud väidete paikapidavuse. Leedu presidendi Valdas Adamkuse ja Läti presidendi Valdis Zatlersi poolt väljendatud seisukohtadest. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

Effects of Broken Symmetry in Tokamaks: Global Braking of Toroidal Rotation and Self-consistent Determination of Neoclassical Magnetic Islands Velocity

International Nuclear Information System (INIS)

Lazzaro, Enzo

2009-01-01

Established results of neoclassical kinetic theory are used in a fluid model to show that in low collisionality regimes (ν and 1/ν) the propagation velocity of Neoclassical Tearing Modes (NTM) magnetic islands of sufficient width is determined self-consistently by the Neoclassical Toroidal Viscosity (NTV) appearing because of broken symmetry. The NTV effect on bulk plasma rotation, may also explain recent observations on momentum transport. At the same time this affects the role of the neoclassical ion polarization current on neoclassical tearing modes (NTM) stability.

Submicroscopic pores grafted using the residual sites produced by swift heavy ions

International Nuclear Information System (INIS)

Mazzei, R.; Betz, N.; Bermudez, G. Garcia; Massa, G.; Smolko, E.

2005-01-01

To produce nuclear track membranes (NTM) with submicroscopic pores poly(vinylidene difluoride) (PVDF) foils were irradiated with Cl, Ag and Pb ions. Then they were chemically etched for different times and grafted with acrylic acid. The grafting yields were determined by weight measurements as a function of ion fluence, etching time and also analysed using Fourier transform infrared spectroscopy. Both measurements suggest that the acrylic acid was grafted on the pore wall of the NTM using the active sites left by the ion beam

Raadiomängud Eestis Teise maailmasõja ajal ja järel. 1.-7. osa / Jaak Pihlau

Index Scriptorium Estoniae

Pihlau, Jaak, 1937-2014

2010-01-01

Luureoperatsioonidest Teise maailmasõja ajal. Eesti territooriumiga seotud Abwehr'i luuregruppidest ja Eesti alal Teise maailmasõja ajal tegutsenud luurekoolidest. Raadiomängudest (Blind, Sever, Javka jm.). Eestlastest Saksa Soome luureüksustes. Lennuoperatsioone alustamine USA poolt Leetu 1950. aastal. USA ja Briti luurejuhtide kohtumisest Münchenis. Eesti agentide saabumisest Lätti. Briti-Eesti luureagentide saabumisest Eestisse 1952. aastal. Eesti NSV Riikliku Julgeoleku Ministeeriumi poolt alustatud raadiomängust "Universitet", hilisema nimega "Berkut". USA luureoperatsioonidest Leetu ja Eestisse

[Effects of planting system on soil and water conservation and crop output value in a sloping land of Southwest China].

Science.gov (United States)

Xiang, Da-Bing; Yong, Tai-Wen; Yang, Wen-Yu; Yu, Xiao-Bo; Guo, Kai

2010-06-01

A three-year experiment was conducted to study the effects of wheat/maize/soybean with total no-tillage and mulching (NTM), wheat/maize/soybean with part no-tillage and part mulching (PTM), wheat/maize/soybean with total tillage without mulching (TWM), and wheat/maize/ sweet potato with total tillage without mulching (TWMS) on the soil and water conservation, soil fertility, and crop output value in a sloping land of Southwest China. The average soil erosion amount and surface runoff of NTM were significantly lower than those of the other three planting systems, being 1189 kg x hm(-2) and 215 m3 x hm(-2), and 10.6% and 84.7% lower than those of TWMS, respectively. The soil organic matter, total N, available K and available N contents of NTM were increased by 15.7%, 18.2%, 55.2%, and 25.9%, respectively, being the highest among the test planting systems. PTM and TWM took the second place, and TWMS pattern had the least. NTM had the highest annual crop output value (18809 yuan x hm(-2)) and net income (12619 yuan x hm(-2)) in three years, being 2.2% -20.6% and 3.8% -32.9% higher than other three planting systems, respectively. In a word, the planting system wheat/maize/soybean was more beneficial to the water and soil conservation and the improvement of soil fertility and crop output value, compared with the traditional planting system wheat/maize/sweet potato.

Tattoo-associated nontuberculous mycobacterial skin infections--multiple states, 2011-2012.

Science.gov (United States)

2012-08-24

Permanent tattoos have become increasingly common, with 21% of adults in the United States reporting having at least one tattoo. On rare occasions, outbreaks of nontuberculous mycobacterial (NTM) skin infections have been reported after tattooing. In January 2012, public health officials in New York received reports of Mycobacterium chelonae skin infections in 14 New York residents who received tattoos during September-December 2011. All infections were associated with use of the same nationally distributed, prediluted gray ink manufactured by company A. CDC disseminated an Epi-X public health alert to identify additional tattoo-associated NTM skin infections; previously identified cases were reported from three states (Washington, Iowa, and Colorado). Public health investigations by CDC, state and local health departments, and the Food and Drug Administration (FDA) found NTM contamination in tattoo inks used in two of five identified clusters. All infected persons were exposed to one of four different brands of ink. NTM contamination of inks can occur during the manufacturing process as a result of using contaminated ingredients or poor manufacturing practices, or when inks are diluted with nonsterile water by tattoo artists. No specific FDA regulatory requirement explicitly provides that tattoo inks must be sterile. However, CDC recommends that ink manufacturers ensure ink is sterile and that tattoo artists avoid contamination of ink through dilution with nonsterile water. Consumers also should be aware of the health risks associated with getting an intradermal tattoo.

A dual enzyme functionalized nanostructured thulium oxide based interface for biomedical application

Science.gov (United States)

Singh, Jay; Roychoudhury, Appan; Srivastava, Manish; Solanki, Pratima R.; Lee, Dong Won; Lee, Seung Hee; Malhotra, B. D.

2013-12-01

In this paper, we present results of the studies related to fabrication of a rare earth metal oxide based efficient biosensor using an interface based on hydrothermally prepared nanostructured thulium oxide (n-Tm2O3). A colloidal solution of prepared nanorods has been electrophoretically deposited (EPD) onto an indium-tin-oxide (ITO) glass substrate. The n-Tm2O3 nanorods are found to provide improved sensing characteristics to the electrode interface in terms of electroactive surface area, diffusion coefficient, charge transfer rate constant and electron transfer kinetics. The structural and morphological studies of n-Tm2O3 nanorods have been carried out by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopic techniques. This interfacial platform has been used for fabrication of a total cholesterol biosensor by immobilizing cholesterol esterase (ChEt) and cholesterol oxidase (ChOx) onto a Tm2O3 nanostructured surface. The results of response studies of the fabricated ChEt-ChOx/n-Tm2O3/ITO bioelectrode show a broad linear range of 8-400 mg dL-1, detection limit of 19.78 mg (dL cm-2)-1, and high sensitivity of 0.9245 μA (mg per dL cm-2)-1 with a response time of 40 s. Further, this bioelectrode has been utilized for estimation of total cholesterol with negligible interference (3%) from analytes present in human serum samples. The utilization of this n-Tm2O3 modified electrode for enzyme-based biosensor analysis offers an efficient strategy and a novel interface for application of the rare earth metal oxide materials in the field of electrochemical sensors and bioelectronic devices.In this paper, we present results of the studies related to fabrication of a rare earth metal oxide based efficient biosensor using an interface based on hydrothermally prepared nanostructured thulium oxide (n-Tm2O3). A colloidal solution of prepared

Diffuse Pulmonary Uptake of Tc-99m Methylene Diphosphonate in a Patient with Non-tuberculosis Mycobacterial Infection

International Nuclear Information System (INIS)

Kwon, Hyun Woo; Chung, June Key; Lee, Dong Soo; Ab-Aziz, Aini

2010-01-01

Extra-osseous uptake of bone-seeking radiopharmaceuticals has been reported at various sites and it is known to be induced by various causes. Diffuse pulmonary infection, such as tuberculosis, can be a cause of lung uptake of bone-scan agent. Here we report on a patient with non-tuberculosis mycobacterial infection (NTM) who demonstrated diffuse pulmonary uptake on Tc-99m MDP bone scan. After medical treatment for NTM, the patient's lung lesions improved. Estra skeletal lung Tc-99m MDP uptake on bone scan may suggest lung parenchymal damage associated with disease activity.

Kes vajab pooltõdedele rajatud patriotismi / Valle-Sten Maiste

Index Scriptorium Estoniae

Maiste, Valle-Sten, 1972-

2007-01-01

Kuressaare Linnateatri ja ühenduse R.A.A.A.M koostöös valminud dokumentaalmaterjalidel põhinevast lavastusest Betti Alverist ja Heiti Talvikust "Võlg". Loo autor on Katrin Saukas, lavastaja Merle Karusoo

Control system of neoclassical tearing modes in real time on HL-2A tokamak

Science.gov (United States)

Yan, Longwen; Ji, Xiaoquan; Song, Shaodong; Xia, Fan; Xu, Yuan; Ye, Jiruo; Jiang, Min; Chen, Wenjin; Sun, Tengfei; Liang, Shaoyong; Ling, Fei; Ma, Rui; Huang, Mei; Qu, Hongpeng; Song, Xianming; Yu, Deliang; Shi, Zhongbin; Liu, Yi; Yang, Qingwei; Xu, Min; Duan, Xuru; Liu, Yong

2017-11-01

The stability and performance of tokamak plasmas are routinely limited by various magneto-hydrodynamic instabilities, such as neoclassical tearing modes (NTMs). This paper presents a rather simple method to control the NTMs in real time (RT) on a tokamak, including the control principle of a feedback approach for RT suppression and stabilization for the NTMs. The control system combines Mirnov, electron cyclotron emission, and soft X-ray diagnostics used for determining the NTM positions. A methodology for fast detection of 2/1 or 3/2 NTM positions with 129 × 129 grid reconstruction is elucidated. The forty poloidal angles for steering the electron cyclotron resonance heating (ECRH)/electron cyclotron current drive launcher are used to establish the alignment of antenna mirrors with the center of the NTM and to ensure launcher emission intersecting with the rational surface of a magnetic island. Pilot experiments demonstrate the RT control capability to trace the conventional tearing modes (CTMs) in the HL-2A tokamak. The 2/1 CTMs have been suppressed or stabilized by the ECRH power deposition on site or with the steerable launcher.

New physics capabilities from the upgraded Thomson scattering diagnostic on MAST

Energy Technology Data Exchange (ETDEWEB)

Gibson, K J; Barratt, N; Snape, J; Tallents, G J; Thornton, A [Department of Physics, University of York, Heslington, York (United Kingdom); Chapman, I; Conway, N; Dunstan, M R; Field, A R; Garzotti, L; Kirk, A; Lloyd, B; Meyer, H; Naylor, G; O' Gorman, T; Scannell, R; Shibaev, S; Temple, D; Pinches, S; Valovic, M, E-mail: keiran.gibson@york.ac.u [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon (United Kingdom)

2010-12-15

The newly upgraded MAST Thomson scattering (TS) system provides excellent spatial resolution ({approx}1 cm) at over 130 radial locations across a full plasma diameter, and utilizes eight individual Nd: :YAG laser systems which can be fired sequentially, providing electron temperature and density profiles approximately every 4 ms throughout a plasma discharge. By operating the system in burst mode, whereby the laser separation can be adjusted to within a few microseconds of each other, it is possible to obtain detailed profiles of transient and periodic phenomena such as sawteeth crashes, massive gas injection for disruption mitigation and the temperature perturbations associated with neoclassical tearing mode (NTM) islands. Following Fitzpatrick et al (1995 Phys. Plasmas 2 825), we consider a simplified model in which finite parallel diffusive heat transport can provide a threshold for NTM island growth and demonstrate that the TS derived electron temperature profiles around an island can be used to obtain both the island width and the critical island width below which temperature gradients are maintained across the island, potentially removing the bootstrap current drive for the NTM. Initial results from high beta, neutral beam injection heated discharges on MAST show that the measured island width inferred from the TS data is in good agreement with magnetic estimates of the island width (considering both a cylindrical approximation and using a full field line tracing estimate). The temporal behaviour of the island width obtained from the magnetic diagnostics indicates that for the scenarios considered to date, finite parallel diffusion is likely to play an important role in NTM threshold physics in MAST.

Nontuberculous mycobacteria in Middle East: Current situation and future challenges

Directory of Open Access Journals (Sweden)

Ali Akbar Velayati

2015-01-01

Mycobacterium fortuitum was the most common rapid growing mycobacteria (RGM isolated from both clinical (269 out of 447 RGM; 60.1% and environmental (135 out of 289 RGM; 46.7% samples. Mycobacterium avium complex (MAC was the most common slow growing mycobacteria (SGM isolated from clinical samples (140 out of 637 SGM; 21.9%. An increasing trend in NTM isolation from the Middle East was noted over the last 5 years. This review demonstrates the increasing concern regarding NTM disease in the Middle East, emphasizing the need for regional collaboration and coordination in order to respond appropriately.

Diffuse Pulmonary Uptake of Tc-99m Methylene Diphosphonate in a Patient with Non-tuberculosis Mycobacterial Infection

Energy Technology Data Exchange (ETDEWEB)

Kwon, Hyun Woo; Chung, June Key; Lee, Dong Soo [Seoul National University College of Medicine, Seoul (Korea, Republic of); Ab-Aziz, Aini [University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, (Morocco)

2010-06-15

Extra-osseous uptake of bone-seeking radiopharmaceuticals has been reported at various sites and it is known to be induced by various causes. Diffuse pulmonary infection, such as tuberculosis, can be a cause of lung uptake of bone-scan agent. Here we report on a patient with non-tuberculosis mycobacterial infection (NTM) who demonstrated diffuse pulmonary uptake on Tc-99m MDP bone scan. After medical treatment for NTM, the patient's lung lesions improved. Estra skeletal lung Tc-99m MDP uptake on bone scan may suggest lung parenchymal damage associated with disease activity.

Are we overlooking infections owing to non-tuberculous mycobacteria during routine conventional laboratory investigations?

Directory of Open Access Journals (Sweden)

Kushal Garima

2012-01-01

Full Text Available A large number of potentially pathogenic non-tuberculous mycobacteria (NTM encountered in the clinical laboratory makes it necessary to identify their species to ensure appropriate treatment. However, labor-intensive conventional methods of speciation are not used in every laboratory, and hence NTM infections are often ignored. Polymerase chain reaction (PCR restriction analysis (PRA was applied in this study for early identification and speciation of mycobacterial species on 306 cultures of acid-fast bacilli isolated from patients suspected of suffering from tuberculosis. Mycobacterium tuberculosis was identified in 85.6% of the isolates. The NTM isolated most commonly was Mycobacterium kansasii/gastri group (3.5%, followed by Mycobacterium fortuitum (3.2%. Four of the M. fortuitum were grown from cultures obtained on the same day, but from samples from different patients and were probably laboratory contaminants. Mycobacterium intracellulare and Mycobacterium avium were identified in 2.94% and 2.28% of the isolates, respectively. Three isolates of M. avium and two isolates of M. intracellulare were obtained in repeated cultures from sputum samples of the same patients and were thus pathogenic. A single isolate of Mycobacterium abscessus was obtained from a breast abscess. A rare pathogen Mycobacterium phocaicum was isolated from one patient with epididymitis. However, whether it was the causative agent of epididymitis in this patient remains doubtful. The results of this study highlight the importance of speciation of mycobacteria for appropriate diagnosis and the importance of including molecular assays to augment conventional methods of diagnosis of mycobacterial diseases for rapid identification of NTM so that these potential pathogens are not overlooked in routine diagnostic procedures.

Measurement of intraocular pressure using the NT-4000: a new non-contact tonometer equipped with pulse synchronous measurement function.

Science.gov (United States)

Yaoeda, Kiyoshi; Shirakashi, Motohiro; Fukushima, Atsushi; Funaki, Shigeo; Funaki, Haruko; Ofuchi, Nobutaka; Nakatsue, Tomoko; Abe, Haruki

2005-06-01

NT-4000 (Nidek Co. Ltd., Gamagori, Japan) is a new non-contact tonometer (NCT) equipped with pulse synchronous measurement function that can measure intraocular pressure (IOP) synchronized with the ocular pulse. The purpose of this study was to evaluate the usefulness of NT-4000 in normal subjects and in patients with glaucoma and ocular hypertension. This study included 175 eyes of 175 subjects. Firstly, the IOP was measured using NT-4000 without the pulse synchronous measurement function (NTn). Secondly, the IOP at peak, middle, and trough phases of the pulse signal were measured using NT-4000 with the pulse synchronous measurement function (NTp, NTm, NTt, respectively). Additionally, the IOP was measured with Goldmann applanation tonometer (GT). The coefficient of variation (CV) of three readings in the NCT measurements was used to evaluate the intra-session reproducibility. Statistical comparisons were performed using Wilcoxon signed rank test and one-way analysis of variance with Scheffe's test. Linear regression analysis was used to calculate correlation coefficients. P values less than 0.05 were accepted as statistically significant. The CV of NTn, NTp, NTm, and NTt were 6.4%, 5.5%, 4.9%, and 5.2%, respectively. The CV of NTp, NTm, and NTt were significantly smaller than that of NTn (P = 0.007, P < 0.001, P < 0.001, respectively). NTp was significantly higher than NTt (P = 0.038). GT was significantly correlated with NTn, NTp, NTm, and NTt (r = 0.898, P < 0.001; r = 0.912, P < 0.001; r = 0.908, P < 0.001; r = 0.900, P < 0.001, respectively). NT-4000 can detect the fluctuation of IOP associated with the ocular pulse.

Liquid culture enhances diagnosis of patients with milder forms of non-tuberculous mycobacterial lung disease.

Science.gov (United States)

Lee, H; Han, J-H; Park, H Y; Jeon, K; Huh, H J; Ki, C-S; Lee, N Y; Koh, W-J

2017-03-01

To evaluate the proportion and clinical characteristics of patients with non-tuberculous mycobacteria (NTM) lung disease diagnosed based on positive culture results in liquid medium only. We reviewed the medical records of 978 patients diagnosed with NTM lung disease. All clinical samples were cultured in both solid and liquid media. Of the 978 patients, 111 (11.3%) were culture-positive in liquid medium only (liquid culture group), and 867 (88.7%) (solid culture group) on solid medium, regardless of the culture results in liquid medium. At the time of diagnosis, the liquid culture group was less likely than the solid culture group to have haemoptysis (11.7% vs. 20.0%, P = 0.04), positive sputum smear for acid-fast bacilli (14.4% vs. 50.2%, P disease (3.6% vs. 14.6%, P = 0.001). During the median follow-up period of 28.9 months (interquartile range 19.1-41.6), the proportion of patients requiring antibiotic treatment was lower in the liquid culture group than in the solid culture group (44.1% vs. 61.6%, P culture is helpful in the diagnosis of patients with less severe forms of NTM lung disease.

Current Methods in the Molecular Typing of Mycobacterium tuberculosis and Other Mycobacteria

Science.gov (United States)

van Ingen, Jakko; Dziadek, Jarosław; Mazur, Paweł K.; Bielecki, Jacek

2014-01-01

In the epidemiology of tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases, as in all infectious diseases, the key issue is to define the source of infection and to disclose its routes of transmission and dissemination in the environment. For this to be accomplished, the ability of discerning and tracking individual Mycobacterium strains is of critical importance. Molecular typing methods have greatly improved our understanding of the biology of mycobacteria and provide powerful tools to combat the diseases caused by these pathogens. The utility of various typing methods depends on the Mycobacterium species under investigation as well as on the research question. For tuberculosis, different methods have different roles in phylogenetic analyses and person-to-person transmission studies. In NTM diseases, most investigations involve the search for environmental sources or phylogenetic relationships. Here, too, the type of setting determines which methodology is most suitable. Within this review, we summarize currently available molecular methods for strain typing of M. tuberculosis and some NTM species, most commonly associated with human disease. For the various methods, technical practicalities as well as discriminatory power and accomplishments are reviewed. PMID:24527454

Influence of anomalous transport phenomena on onset of Neoclassical Tearing Modes in tokamaks

International Nuclear Information System (INIS)

Konovalov, S.V.; Mikhailovskii, A.B.; Shirokov, M.S.; Ozeki, T.; Takizuka, T.; Hayashi, N.

2005-01-01

Influence of anomalous perpendicular heat transport and anomalous ion perpendicular viscosity on conditions of Neoclassical Tearing Mode (NTM) onset is studied theoretically. Series of various parallel transport mechanisms competitive to anomalous cross-island heat transport in formation of the perturbed electron and ion temperature profiles within the island are considered. Analytical solutions to respective heat balance equations were found and perturbed temperature profiles were calculated rigorously. The partial contributions from the plasma electron and ion temperature perturbations in the bootstrap drive of the mode and magnetic curvature effect were then accounted in construction of a generalized transport threshold model of NTMs. Taking into account the curvature effect weakening in the generalized transport threshold model predicts notable improvement of NTM stability. The anomalous perpendicular ion viscosity was shown to modify collisionality dependence of polarization current effect reducing it to the low collisionality limit. The bootstrap drive of NTM in the presence of anomalous perpendicular ion viscosity was found to be dependent on the island rotation frequency and direction. For island rotating in direction of the electron diamagnetic drift viscosity effect was shown to be stabilizing. The role of viscosity effect grows rapidly with rise of the plasma ion temperature. (author)

Eeluurimiskohtunik kriminaalmenetluse seadustiku eelnõus / Meelis Eerik

Index Scriptorium Estoniae

Eerik, Meelis, 1976-

2000-01-01

Eeluurimiskohtuniku funktsioonidest uurimistoimingute sanktsioneerimisel, kriminaalmenetluse tagamisel, kohtueelses, väljaandmis- ja kohtumenetluses ning eeluurimiskohtuniku poolt tehtavatest lahenditest

Circular causality and indeterminism in machines for design

Directory of Open Access Journals (Sweden)

Thomas Fischer

2014-12-01

Full Text Available Presenting a hard-to-predict typography-varying system predicated on Nazi-era cryptography, the Enigma cipher machine, this paper illustrates conditions under which unrepeatable phenomena can arise, even from straight-forward mechanisms. Such conditions arise where systems are observed from outside of boundaries that arise through their observation, and where such systems refer to themselves in a circular fashion. It argues that the Enigma cipher machine is isomorphous with Heinz von Foersters portrayals of non-triviality in his non-trivial machine (NTM, but not with surprising human behaviour, and it demonstrates that the NTM does not account for spontaneity as it is observed in humans in general.

[Biologics and mycobacterial diseases].

Science.gov (United States)

Tsuyuguchi, Kazunari; Matsumoto, Tomoshige

2013-03-01

Various biologics such as TNF-alpha inhibitor or IL-6 inhibitor are now widely used for treatment of rheumatoid arthritis. Many reports suggested that one of the major issues is high risk of developing tuberculosis (TB) associated with using these agents, which is especially important in Japan where tuberculosis still remains endemic. Another concern is the risk of development of nontuberculous mycobacterial (NTM) diseases and we have only scanty information about it. The purpose of this symposium is to elucidate the role of biologics in the development of mycobacterial diseases and to establish the strategy to control them. First, Dr. Tohma showed the epidemiologic data of TB risks associated with using biologics calculated from the clinical database on National Database of Rheumatic Diseases by iR-net in Japan. He estimated TB risks in rheumatoid arthritis (RA) patients to be about four times higher compared with general populations and to become even higher by using biologics. He also pointed out a low rate of implementation of QuantiFERON test (QFT) as screening test for TB infection. Next, Dr. Tokuda discussed the issue of NTM disease associated with using biologics. He suggested the airway disease in RA patients might play some role in the development of NTM disease, which may conversely lead to overdiagnosis of NTM disease in RA patients. He suggested that NTM disease should not be uniformly considered a contraindication to treatment with biologics, considering from the results of recent multicenter study showing relatively favorable outcome of NTM patients receiving biologics. Patients with latent tuberculosis infection (LTBI) should receive LTBI treatment before starting biologics. Dr. Kato, a chairperson of the Prevention Committee of the Japanese Society for Tuberculosis, proposed a new LTBI guideline including active implementation of LTBI treatment, introducing interferon gamma release assay, and appropriate selection of persons at high risk for

J. Laidoneri komisjoni raportite kriitikast ja retseptsioonist seoses kindrali tegevusega Iraagis. I-II / Tanno Tilgar

Index Scriptorium Estoniae

Tilgar, Tanno, 1971-

2011-01-01

Suurbritannia ja Türgi poliitilistest vastuoludest 1925. aasta septembris, brittide initsiatiivist kristlaste deportatsiooni uurimiseks. Kaldealastest, nende suhetest türklaste ja kurdidega 1925. aasta septembri deportatsiooni kontekstis. Laidoneri komisjoni tegevuse taustast. Poliitiliste otsustajate ja uurijate arvamustest komisjoni aruannete kohta. Põhi- ja lisaraporti käsitlustest ja nende usaldusväärsusest. Piirikülade külastustest J. Laidoner poolt. Raporti osade ja nende kohta esitatud kriitiliste väidete analüüs. Kindlate (Iraagi) külade okupeerimisest Türgi militaarpostide ja patrullide poolt. Briti lennuväe lendudest üle nn. Brüsseli liini. Kristlaste deporteerimisest

Kullast vilepilli voolides / Mare Müürsepp

Index Scriptorium Estoniae

Müürsepp, Mare

2002-01-01

TPÜ kaugõppe üliõpilane, klassiõpetaja Kristine Niit võrdles oma diplomitöös lugemise ilminguid kahte sorti 3.-4. klassides. Pooltes klassides õpetavad õpetajad, kes usuvad, et lapsed suudavad ja tahavad ise enesele huvitavat lugemist valida, kes kasutavad lugemiselamuste kinnistamiseks mitmekesiseid võtteid, nagu vaba vestlus, rühmatöö, vastastikune arvamuslehtede lugemine, joonistamine jms. Pooltes klassides oli ametis range lugemise juht: kohustuslik nimekiri, tähtajad, lünktekstid, faktiküsimused loetu kontrollimiseks. Peamine uurimisvõte oli lugeja enesemääratluse test, autorid W. A. Henk ja S. A. Melnick.

Segadused mitteresidentide poolt saadud dividendide maksustamisel / Lasse Lehis, Erki Uustalu

Index Scriptorium Estoniae

Lehis, Lasse, 1972-

1998-01-01

Mitteresidentide dividendide tulumaksustamisest ja tuluallikariigi esmaõigusest selle puhul, topeltmaksustamise vältimisest, alakapitalisatsioonist ning intresside ja tulude maksustamise erinevusest

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.

Science.gov (United States)

Floto, R Andres; Olivier, Kenneth N; Saiman, Lisa; Daley, Charles L; Herrmann, Jean-Louis; Nick, Jerry A; Noone, Peadar G; Bilton, Diana; Corris, Paul; Gibson, Ronald L; Hempstead, Sarah E; Koetz, Karsten; Sabadosa, Kathryn A; Sermet-Gaudelus, Isabelle; Smyth, Alan R; van Ingen, Jakko; Wallace, Richard J; Winthrop, Kevin L; Marshall, Bruce C; Haworth, Charles S

2016-01-01

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). Pulmonary disease caused by NTM has emerged as a major threat to the health of individuals with CF but remains difficult to diagnose and problematic to treat. In response to this challenge, the US Cystic Fibrosis Foundation (CFF) and the European Cystic Fibrosis Society (ECFS) convened an expert panel of specialists to develop consensus recommendations for the screening, investigation, diagnosis and management of NTM pulmonary disease in individuals with CF. Nineteen experts were invited to participate in the recommendation development process. Population, Intervention, Comparison, Outcome (PICO) methodology and systematic literature reviews were employed to inform draft recommendations. An anonymous voting process was used by the committee to reach consensus. All committee members were asked to rate each statement on a scale of: 0, completely disagree, to 9, completely agree; with 80% or more of scores between 7 and 9 being considered 'good' agreement. Additionally, the committee solicited feedback from the CF communities in the USA and Europe and considered the feedback in the development of the final recommendation statements. Three rounds of voting were conducted to achieve 80% consensus for each recommendation statement. Through this process, we have generated a series of pragmatic, evidence-based recommendations for the screening, investigation, diagnosis and treatment of NTM infection in individuals with CF as an initial step in optimising management for this challenging condition. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Dual skin tests with Mycobacterium avium sensitin and PPD to detect misdiagnosis of latent tuberculosis infection.

Science.gov (United States)

Larson, E M; O'Donnell, M; Chamblee, S; Horsburgh, C R; Marsh, B J; Moreland, J D; Johnson, L S; von Reyn, C Fordham

2011-11-01

A positive tuberculin skin test (TST) may indicate cross-reacting immunity to non-tuberculous mycobacteria (NTM) and not latent tuberculosis infection (LTBI). To assess misclassification of LTBI, as assessed by skin testing with Mycobacterium avium sensitin (MaS), and to determine how this misclassification affects the analysis of risk factors for LTBI. In a population-based survey, participants underwent skin testing with M. tuberculosis purified protein derivative (PPD) and MaS. A PPD-dominant skin test was a reaction that was ≥ 3 mm larger than the MaS reaction; a MaS-dominant skin test was a reaction that was ≥ 3 mm larger than the PPD reaction. Of 447 randomly selected persons, 135 (30%) had a positive PPD test. Of these, 21 (16%) were MaS- dominant, and were therefore attributable to NTM and misclassified as LTBI. PPD reactions of 5-14 mm were more likely to be misclassified than those ≥ 15 mm (OR = 5.0, 95%CI 1.9-13.2). Adjusting for misclassification had only a small impact on the analysis of risk factors for LTBI. A substantial number of individuals who are diagnosed with LTBI are actually sensitized to NTM. Using dual skin testing would reduce misdiagnosis and prevent unnecessary treatment.

[Non-tuberculous mycobacterial infections related to esthetic care in France, 2001-2010].

Science.gov (United States)

Couderc, C; Carbonne, A; Thiolet, J M; Brossier, F; Savey, A; Bernet, C; Ortmans, C; Lecadet-Morin, C; Coudière, I; Aggoune, M; Astagneau, P; Coignard, B; Cambau, E

2011-07-01

Non-tuberculous mycobacteria (NTM) infections usually occur in immunocompromised patients but also in immunocompetent patients following invasive procedures, especially for esthetic purposes. Since 2001, 20 episodes (57 cases) of NTM infections, seven of which (43 cases) were related to esthetic care, have been reported to the regional infection control coordinating centers (RICCC), the local health authorities (LHA), and the national institute for public health surveillance. Four notifications (40 cases) were related to non-surgical procedures performed by general practitioners in private settings: mesotherapy, carboxytherapy, and sclerosis of microvaricosities. The three other notifications (three cases) concerned surgical procedures-lifting and mammary prosthesis. Practice evaluations performed by the RICCC and LHA for five notifications showed deficiency of standard hygiene precautions and tap water misuse for injection equipment cleaning, or skin disinfection. Microbiological investigations (national reference center for mycobacteria) demonstrated the similarity of patient and environmental strains: in one episode (16 cases after mesotherapy), M. chelonae isolated from tap water was similar to those isolated from 11 cases. Healthcare-associated NTM infections are rare but have a potentially severe outcome. These cases stress the need of healthcare-associated infection notifications in outpatient settings. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Ausambad Newfoundlandi eestisoost seenesõpradele / foto: Helen Spencer

Index Scriptorium Estoniae

2008-01-01

Newfoundlandis asuva Brother Brennan Environmental Education Centre (BBEEC) poolt korraldadavatest seenekursustest, mille õppejõuks kutsuti Newfoundlandis seenehuvilistena tuntud Maria ja Andrus Voitk

Enforcing the Judgments of the ECtHR in Russia in Light of the Amendments to the Law on the Constitutional Court / Kerttu Mäger

Index Scriptorium Estoniae

Mäger, Kerttu, 1986-

2016-01-01

Euroopa Inimõiguste Kohtu (EIK) kohtuotsuste jõustamisest Venemaal. EIK kohtuotsuste kohustuslikkusest. EIK kohtuotsuste tõlgendamisest ja valikulisest rakendamisest Venema konstitutsioonikohtu poolt

An economic approach on countering the misuse of the right to challenge judges: an experiment / Joep Sonnemans, Frans van Dijk, Bart Donders... [jt.

Index Scriptorium Estoniae

2018-01-01

Kohtunike tagasikutsumise protseduurist erinevates riikides (väidetava erapoolikuse tõttu), selle kuritarvitamisest juristide poolt. Eksperimendist kohtuniku tagasikutsumise mõjude kohta menetlusele

Autoriõiguse küsimusi kunstimuuseumide kogude digitaliseerimisel : [bakalaureusetöö] / Marget Kukk ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kadri Aua

Index Scriptorium Estoniae

Kukk, Marget

2004-01-01

Traditsiooniliste muuseumide olemus ja nende tegevus digitaalsel ajastul, traditsiooniliste kunstiteoste digitaliseerimine autoriõiguse vaatenurgast, muuseumide poolt digitaliseeritud kujutiste kogumi kui andmebaasi kaitse

Kõrvemaa Karikas 2011 / Katrin Liiv, Õnne Halliko

Index Scriptorium Estoniae

Liiv, Katrin

2011-01-01

MTÜ Estonian Endurance Riding poolt Kõrvemaa Matka- ja Suusakeskuses korraldatud kestvusratsutamise võistlusest Kõrvemaa Karikas 2011, kus selgitati ka poniklassi Eesti meistrid kestvusratsutamises

Innovaatilisus on jätkuvalt heal tasemel / Aavo Heinlo

Index Scriptorium Estoniae

Heinlo, Aavo

2008-01-01

Euroopa Ühenduse poolt korraldatud innovatsiooniuuringu tulemustest. Innovaatilised ettevõtted, innovaatilise tegevuse liigid ja kulutused, innovaatilisus ja avalik sektor. Lisatud tabelid ja diagrammid

EIÕK staatus Eesti õigussüsteemis / Rait Maruste

Index Scriptorium Estoniae

Maruste, Rait, 1953-

1996-01-01

Euroopa inimõiguste konventsiooni ratifitseerimine Eesti poolt, selle siseriiklik õiguslik siduvus ja reservatsioonid, koht siseriiklikus õigusnormide hierarhias, territoriaalne kehtivus ning kohaldatavus Eesti kohtutes

Asendusemaduse seadustamine Eestis - probleemid ja perspektiivid : [magistritöö] / Kelly Kruusimägi ; Tartu Ülikool, õigusteaduskond ; juhendajad: Ants Nõmper, Jaan Sootak

Index Scriptorium Estoniae

Kruusimägi, Kelly

2011-01-01

Mõistetest ja asendusemaduse vormidest, praktika arengust, Eesti seisukohtadest, asendusemaduse poolt- ja vastuargumentidest, kasutamise etingimustest, tasust, regulatsioonist, lepingust tuleneva kohustuse täitmise nõudest

Ühiselt Eesti põllumehe kaitsel / Olav Kreen

Index Scriptorium Estoniae

Kreen, Olav

2004-01-01

Eesti Põllumajandus-Kaubanduskoja poolt 30. jaanuaril 2004. a. Haapsalus korraldatud seminarist, kus tutvustati Taani ja Belgia põllumajandusorganisatsioone ning Euroopa põllumajandusorganisatsiooni COPA/COGECA

Laste kasvatamisel tekkivate suhete õiguslik regulatsioon ja selle muutmine Eestis : [bakalaureusetöö] / Juta Saarevet ; Tartu Ülikool, õigusteaduskond ; juhendaja: Edgar Salumaa

Index Scriptorium Estoniae

Saarevet, Juta

2003-01-01

Laste kasvatamisel tekkivad suhted ja nende õiguslik regulatsioon, argumendid perekonnaseaduses vanema kasvatusalaste suhete regulatsiooni poolt ja vastu, Saksa perekonnaõiguse analoogi toomine Eesti õiguskorda

From veto players to agenda-setters? National Parliaments and their „Green card“ to the European Comission / Cristina Fasone , Diane Fromage

Index Scriptorium Estoniae

Fasone, Cristina

2016-01-01

Liikmesriikide parlamentide rollist Euroopa Liidu poliitikas pärast Lissaboni lepingut. Komisjoni presidendi Barroso poolt 2006. aastal algatatud poliitilisest dialoogist ning „rohelisest kaardist“

On the interplay between neoclassical tearing modes and nonlocal transport in toroidal plasmas

Science.gov (United States)

Ji, X. Q.; Xu, Y.; Hidalgo, C.; Diamond, P. H.; Liu, Yi; Pan, O.; Shi, Z. B.; Yu, D. L.

2016-09-01

This Letter presents the first observation on the interplay between nonlocal transport and neoclassical tearing modes (NTMs) during transient nonlocal heat transport events in the HL-2A tokamak. The nonlocality is triggered by edge cooling and large-scale, inward propagating avalanches. These lead to a locally enhanced pressure gradient at the q = 3/2 (or 2/1) rational surface and hence the onset of the NTM in relatively low β plasmas (βN < 1). The NTM, in return, regulates the nonlocal transport by truncation of avalanches by local sheared toroidal flows which develop near the magnetic island. These findings have direct implications for understanding the dynamic interaction between turbulence and large-scale mode structures in fusion plasmas.

Majanduskitsikus võib korruptsiooni süvendada / Tarmu Tammerk

Index Scriptorium Estoniae

Tammerk, Tarmu

2008-01-01

Autor selgitab rahvusvahelise korruptsioonivastase organisatsiooni Transparency International poolt määratava korruptsiooniindeksi kujunemist ning põhjuseid, miks Eesti pole veel edetabeli tippu jõudnud

Ohtlik lend / Iain Carson

Index Scriptorium Estoniae

Carson, Iain

2006-01-01

Majanduslikesse raskustesse sattunud Euroopa tsiviillennukite tootjat Airbus, mis kuulub Prantsuse-Saksa-Hispaania emafirmale European Aeronautic Defence and Space (EADS), ootab ees natsionaliseerimine kolme riigi poolt

Okupatsiooni raamatupidaja kaelamurdvad trikid / Anto Raukas ; interv. Juku-Kalle Raid

Index Scriptorium Estoniae

Raukas, Anto, 1935-

2006-01-01

Akadeemik Anto Raukas lõpetas äsja raamatu "Nõukogude okupatsiooni poolt tekitatud keskkonnakahjud". Vt. samas: Isepõlemismootoriga Raukas; Virkko Lepassalu. Paldiskist Venemaale suundunud tuumarongi liikumisest

From Balfron Tower to Crisis Point / Aet Ader

Index Scriptorium Estoniae

Ader, Aet, 1985-

2015-01-01

Londoni arhitektuurifestivalil esindas Eestit arhitektuuribüroo b210 arhitekt Aet Ader, kes valiti Briti Nõukogu poolt osalema festivali alaprogrammi International Architecture Showcase rahvusvahelises residentuuriprogrammis

Õpetajaks õppimas / Mari-Helene Kaber

Index Scriptorium Estoniae

Kaber, Mari-Helene

2008-01-01

Humana People to people liikumise poolt loodud õpetajate koolitamise võrgustikust, mis tegutseb Angolas, Mosambiigis ja Malawis ja kus valmistatakse ette õpetajaid peamiselt maapiirkondade koolidesse

DIALANG and pilot testing / Sirje Jakobson

Index Scriptorium Estoniae

Jakobson, Sirje

2002-01-01

Hollandi haridus-, kultuuri- ja teadusministeeriumi poolt keelteaasta raames korraldatud Euroopa keeleprojekte tutvustavast konverentsist ning kultuuri- ja haridusprojektist DIALANG, mis koostab diagnostilisi teste 14 euroopa keeles

Kohtu loal lapse nimel tehingute tegemine krediidiasutuses : [magistritöö] / Merily Saar ; Tartu Ülikool, õigusteaduskond ; juhendaja: Triin Göttig

Index Scriptorium Estoniae

Saar, Merily, 1987-

2013-01-01

Varahooldusõigusest tulenevast lapse vara säilitamise kohustusest, perekonnaseadusest tulenevatest piirangutest vanema poolt lapse esindajana tehingute tegemisel, lapse nimel väärtpaberitehingute tegemisest

Tarbekaupade ja teenuste turujärelevalve 2003. aastal / Marina Karro, Natali Promet

Index Scriptorium Estoniae

Karro, Marina

2004-01-01

Ülevaade tervisekaitseinspektsiooni poolt teostatud järelvalvest kosmeetikatoodete, kemikaalide, lastetoodete, tarbekaupade, iluteenuseid osutavate ettevõtete ja majutusasutuste üle 2003. a. Tabelid. Diagrammid. Graafik

Leibkondade ja perekondade koosseis Euroopa riikides rahvaloenduste andmetel = Composition of households and families in European countries according to the data of population censuses / Helen Paut

Index Scriptorium Estoniae

Paut, Helen

2005-01-01

Euroopa Liidu Statistikaameti poolt avaldatud 21 Euroopa Liidu riigi andmetele tuginev ülevaade tavaleibkondade ning perekondade suurusest ja koosseisust Euroopa Liidu riikides. Diagrammid. Tabel. Graafik

BA-FA BA-FA : kak sposob razreshenija mezhnatsionalnõhh konfliktov / Lada Davõdova

Index Scriptorium Estoniae

Davõdova, Lada

1997-01-01

Organisatsiooni "People to people Estonia" poolt korraldatud "Workshop on Conflict Resolution in Estonia" - Venekeelse noorsoo integreerimiseks läbi viidud projekt, rahvustevaheliste konfliktide vältimine

Start-up ettevõtja kapitali kaasamist lihtsustavad äriseadustiku muudatused / Maivi Ots

Index Scriptorium Estoniae

Ots, Maivi, 1974-

2015-01-01

20. novembril 2014 Vabariigi Valitsuse poolt Riigikogule menetlemiseks saadetud äriseadustiku muutmise seaduse eelnõust, mille kavandatavad muudatused võimaldavad osaühingutel kapitali lihtsamalt kaasata

Pääsküla sõjaväeobjekti jääkreostus ning piirkonna edasise kasutamise perspektiivid / Triin Uudeväli, Anto Raukas

Index Scriptorium Estoniae

Uudeväli, Triin

2004-01-01

Pääskülas asunud NL-i raketijuhtimisekeskuse ja sideväeosa poolt tekitatud keskkonnareostuse hindamisest, likvideerimisest ning ettepanekutest territooriumi edasiseks kasutamiseks. Kaart. Skeem. Fotod

Novõi jevropeiskii tsentr transportnõhh issledovanii = The new european research centre / Igor Kabashkin

Index Scriptorium Estoniae

Kabashkin, Igor

2004-01-01

Veebruaris 2004 OECD ja transpordiministrite Euroopa Komitee poolt asutatud Euroopa ühendatud transpordiuuringute keskuse (The joint OECD/ECMT Transport Research Centre) ülesannetest, uurimisvaldkondadest ja -projektidest

Maagiline Matrix - muutuste võti / Marika Makarova ; kommenteerinud Ainar Leppik

Index Scriptorium Estoniae

Makarova, Marika

2010-01-01

USA kiropraktiku Richard Bartletti loodud Matrix Energetics tehnikate alusl Ainar Leppiku poolt loodud Maagilise Maatriksi meetodist, mis õpetab muutuste toomist oma ellu. Vestlustest Maagilise Maatriksi õpetajatega

Kohtusüsteemi reguleerimise probleeme / Kai Kullerkupp

Index Scriptorium Estoniae

Kullerkupp, Kai, 1975-

1997-01-01

Kohtute pädevuse piiritlemisest, "õigusemõistmisest" kohtunikuks mitteolevate ametnike poolt, kohtute haldusest, kohtunike õiguslikust seisundist ja teenistusjärelevalvest ning kohtutesisesest tööjaotusest

"Two languages in addition to mother tongue" - will this policy preserve linguistic diversity in Europe? / Tõnu Tender, Triin Vihalemm

Index Scriptorium Estoniae

Tender, Tõnu, 1965-

2009-01-01

Euroopa Komisjoni mitmekeelsuse strateegiale ja Euroopa Nõukogu keeleekspertide poolt läbiviidud kvalitatiivse uurimuse tulemustele tuginedes analüüsitakse Euroopa keelelise mitmekesisuse säilimist

Lozhnõje obeshtshanija / Bradford J. DeLong

Index Scriptorium Estoniae

DeLong, Bradford J.

2006-01-01

Maailma rikkamates riikides peetakse debatte sotsiaalkindlustuse teemadel. Väitest, et riigi poolt finantseeritavad pensioniprogrammid, mis rajanevad kindlaks määratud väljamaksetele, on vananenud

Muudetud IFRS 3 ja IAS 27 / Monika Peetson

Index Scriptorium Estoniae

Peetson, Monika, 1976-

2008-01-01

Rahvusvahelise Raamatupidamisstandardite Nõukogu poolt välja antud muudetud standarditest IFRS 3 "Äriühendused" ja IAS 27 "Konsolideeritud ja konsolideerimata finantsaruanded" ning nendega kaasnevatest muudatustest

Kuidas Tali rehepaplust laia maailma viib / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2004-01-01

Anu Tali ja Eesti-Soome Sümfooniaorkestri kontserdist "Rehepapi radadel". Jaanuari keskpaigas plaadifirma Warner poolt väljaantavast Eesti-Soome Sümfooniaorkestri teisest heliplaadist "Action Passion Illusion"

Parimatest parimate strateegiad : kuidas luuakse strateegiat maailma juhtivates firmades / Vello Rääk

Index Scriptorium Estoniae

Rääk, Vello

2006-01-01

Juhtimisajakirja McKinsey Quarterly poolt läbiviidud strateegilise planeerimise protsessi puudutavast ülemaailmsest online-uuringust selgub, et paljudes ettevõtetes strateegilise planeerimise formaalne protsess ei toimi

"Tuleviku Bauhaus" = "Future Bauhaus" / Pekka Vapaavuori

Index Scriptorium Estoniae

Vapaavuori, Pekka

1994-01-01

Arhitekt Pekka Vapaavuori üle-Euroopalisele üliõpilaste arhitektuurikonkursile esitatud arhitektuurikooli projekt, mis on kavandatud ehitada arhitekt Walter Gropiuse poolt projekteeritud Bauhausi hoone lähedale

Konsensus - lutshshaja forma oboronõ / Jevgenija Garanzha

Index Scriptorium Estoniae

Garanža, Jevgenija, 1979-

2003-01-01

Muutused Eesti kaitsemudelis peavad olema saavutatud kõikide poliitiliste jõudude kokkuleppe tulemusena - sellisele järeldusele jõudsid Isamaaliidu poolt kokku kutsutud ümarlauas osalenud parlamendifraktsioonid

Inglismaal hävitatakse fotoraamatuid

Index Scriptorium Estoniae

1998-01-01

Mapplethorpe'i fotoraamatute konfiskeerimisest Birminghami Ülikooli raamatukogust Birminghami politsei poolt. Politsei on teinud avalduse kirjastusele Random House'ile, et hävitada veel laos olevad fotoalbumid

Kitarrimuusika dimensioonid / Kuldar Kudu

Index Scriptorium Estoniae

Kudu, Kuldar, 1965-2005

2005-01-01

Eesti Kontserdi ja Eesti Kitarriseltsi poolt 11.-14. nov. korraldatud Tartu rahvusvahelistest kitarrimuusikapäevadest "Fiesta de la guitarra", mille raames toimus ka vanamuusiku Jose Moreno meistriklass

Meditsiini tase Eestis Euroopa kõva keskmine / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2005-01-01

Rootsi eraviisiliste meditsiiniuuringute keskuse Health Consumer Powerhouse poolt tehtud analüüsi tulemusena selgus, et Eesti on tervishoiuteenuste poolest 12 riigi seas neljandal kohal. Tabel: Meditsiiniabi

Alaealine - kuriteo toimepanija : [bakalaureusetöö] / Katrin Sarv ; Akadeemia Nord, õigusteaduskond ; juhendaja: Helve Särgava

Index Scriptorium Estoniae

Sarv, Katrin

2001-01-01

Alaealiste poolt sooritatud kuritegude üldiseloomustus, võrdlus Läti, Soome ja Rootsiga, alaealiste kuritegevuse põhjused, kuritegevuse vastu võitlemise alused - kriminaalpreventsioon, kuritegevuse profülaktika

Baltic trade war put on three-month hold / Ieva Tuna

Index Scriptorium Estoniae

Tuna, Ieva

2003-01-01

Baltimaade kaubanduskohtumisel 4. juulil 2003 otsustati kolm kuud oodata protektsionistlike meetmete rakendamisega Läti vastu. Läti esindajad lubasid omalt poolt kaaluda siseturu kaitseks kehtestatud piirangute leevendamist

Druzhinniki sostavili dlja Jõhvi mozaiku / Sirle Sommer-Kalda

Index Scriptorium Estoniae

Sommer-Kalda, Sirle, 1974-

2002-01-01

Jõhvi kaubakeskuse esisel väljakul õpilasmalevlaste poolt valmistatud Virumaad kujutavast põllukividest mosaiikpannoost. Päikest kujutav mosaiik on kavas teha Ontikal. Kommenteerib projekti juht Anne Aedma

Letnii otpusk Barrossu, ili Uravnenije s 25 neizvestnõmi / Marko Saaret

Index Scriptorium Estoniae

Saaret, Marko

2004-01-01

Euroopa Komisjoni juht Jose Manuel Durao Barroso seisab raske valiku ees - kuidas jagada 25 portfelli 25 esitatud kandidaadi vahel. Liikmesriikide poolt Euroopa Komisjoni voliniku kohale esitatud kandidaadid

Prevalence and direct costs of emergency department visits and hospitalizations for selected diseases that can be transmitted by water, United States.

Science.gov (United States)

Adam, E A; Collier, S A; Fullerton, K E; Gargano, J W; Beach, M J

2017-10-01

National emergency department (ED) visit prevalence and costs for selected diseases that can be transmitted by water were estimated using large healthcare databases (acute otitis externa, campylobacteriosis, cryptosporidiosis, Escherichia coli infection, free-living ameba infection, giardiasis, hepatitis A virus (HAV) infection, Legionnaires' disease, nontuberculous mycobacterial (NTM) infection, Pseudomonas-related pneumonia or septicemia, salmonellosis, shigellosis, and vibriosis or cholera). An estimated 477,000 annual ED visits (95% CI: 459,000-494,000) were documented, with 21% (n = 101,000, 95% CI: 97,000-105,000) resulting in immediate hospital admission. The remaining 376,000 annual treat-and-release ED visits (95% CI: 361,000-390,000) resulted in $194 million in annual direct costs. Most treat-and-release ED visits (97%) and costs ($178 million/year) were associated with acute otitis externa. HAV ($5.5 million), NTM ($2.3 million), and salmonellosis ($2.2 million) were associated with next highest total costs. Cryptosporidiosis ($2,035), campylobacteriosis ($1,783), and NTM ($1,709) had the highest mean costs per treat-and-release ED visit. Overall, the annual hospitalization and treat-and-release ED visit costs associated with the selected diseases totaled $3.8 billion. As most of these diseases are not solely transmitted by water, an attribution process is needed as a next step to determine the proportion of these visits and costs attributable to waterborne transmission.

A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance

Science.gov (United States)

Rashid Ali, Muhammad Redzwan S.; Parameswaran, Uma; William, Timothy; Bird, Elspeth; Wilkes, Christopher S.; Lee, Wai Khew; Yeo, Tsin Wen; Anstey, Nicholas M.; Ralph, Anna P.

2015-01-01

Introduction. The burden of tuberculosis is high in eastern Malaysia, and rates of Mycobacterium tuberculosis drug resistance are poorly defined. Our objectives were to determine M. tuberculosis susceptibility and document management after receipt of susceptibility results. Methods. Prospective study of adult outpatients with smear-positive pulmonary tuberculosis (PTB) in Sabah, Malaysia. Additionally, hospital clinicians accessed the reference laboratory for clinical purposes during the study. Results. 176 outpatients were enrolled; 173 provided sputum samples. Mycobacterial culture yielded M. tuberculosis in 159 (91.9%) and nontuberculous Mycobacterium (NTM) in three (1.7%). Among outpatients there were no instances of multidrug resistant M. tuberculosis (MDR-TB). Seven people (4.5%) had isoniazid resistance (INH-R); all were switched to an appropriate second-line regimen for varying durations (4.5–9 months). Median delay to commencement of the second-line regimen was 13 weeks. Among 15 inpatients with suspected TB, 2 had multidrug resistant TB (one extensively drug resistant), 2 had INH-R, and 4 had NTM. Conclusions. Current community rates of MDR-TB in Sabah are low. However, INH-resistance poses challenges, and NTM is an important differential diagnosis in this setting, where smear microscopy is the usual diagnostic modality. To address INH-R management issues in our setting, we propose an algorithm for the treatment of isoniazid-resistant PTB. PMID:25838829

Gazprom : Kremli rusikas ja rahamasin hoiab haardes poolt Euroopat / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2005-01-01

Maailma suurimast gaasitootjast Gazprom, mis autori sõnul on kujunemas Vene võimude üheks olulisemaks välispoliitiliseks tööriistaks, kehastades Moskva mõju samal määral kui Vene armee. Lisad: Gazpromi nähtamatu käsi Leedus; Venemaa mõjuvõimsaim; Gazprom paisub veelgi. Diagramm: Veel erakätes. Kaart: Gazpromi haardes. Tabel: Gazprom

Ettevõtlus, konkurents ja riskid hariduselus / Toomas Saal

Index Scriptorium Estoniae

Saal, Toomas

2002-01-01

Autori hinnangul on kahetsusväärne, et riik kulutab raha riigi omanduses olevate õppeasutuste ülalpidamiseks sõltumata nende asutuste poolt pakutava hariduse kvaliteedist. Kutsehariduskonseptsioon EC/NOR

Any : üheksakümnendate projekt / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2000-01-01

1990. a. New Yorgis loodud korporatsiooni 'Anyone' poolt juhitud konverentse, diskussioone ja publikatsioone ('ANY Magazine', aastaraamatud, raamatuseeria 'Writind Architecture') hõlmavast arhitektuuriprojektist. Any viimasest konverentsist 2000. a. juunis

Eesti tarbijad on kõige optimistlikumad / Hille Tressum

Index Scriptorium Estoniae

Tressum, Hille

2008-01-01

Ilmunud ka: Delovõje Vedomosti 6. aug. lk. 9. Balti kaubanduskontserni Maxima Groupi poolt tellitud tarbijauuringu tulemustest. 62% Eestis küsitletuist arvas, et majanduslangus muudab nende tarbimisharjumusi

Tavatu kriis / Vlady Kellik

Index Scriptorium Estoniae

Kellik, Vlady

2010-01-01

Autor tutvustab Varssavi Transformatsiooni, Integratsiooni ja Globaliseerumise Uurimiskeskuse (TIGER) direktori Grzegorz Kolodko poolt Moskvas Rahandusakadeemia audoktoriks promoveerimise puhul peetud loengut. Teadlase hinnangul osutus majandusbuum neoliberalismi nurisünnitiseks

Mramornaja Britni borjotsja s abortami

Index Scriptorium Estoniae

2006-01-01

Ameerika skulptor Daniel Edwards astub abordi vastu sünnitava Britney Spearsi realistliku skulptuuriga "Monument elu poolt : Sean Prestoni sünd". Eksponeeritakse New Yorgis Capla Kestingi kunstigaleriis

Aktiivse eutanaasia moraalsusest ning legaliseerimise võimalikkusest : [bakalaureusetöö] / Andres Simson ; Tartu Ülikool, õigusteaduskond ; juhendaja: Jaan Sootak

Index Scriptorium Estoniae

Simson, Andres

1999-01-01

Ajalooline ülevaade, aktiivse eutanaasia mõiste, liigid, erinevate koolkondade suhtumine, moraalsuse poolt- ja vastuargumendid, Austraalia eutanaasiaseadused, USA seadusandlus.Vt. ka: Juridica (1999) nr. 7, lk. 342-347

Green Christmas kasvas suureks / Aarne Mäe

Index Scriptorium Estoniae

Mäe, Aarne, 1967-

2004-01-01

Suurbritannia rockansambli Paradise Lost' kontsertidest 18. dets. Rakvere spordihallis ja Riias Kipsala hallis, rockfestivali Green Christmas korraldamisest Gunnar Viese ja Oleg Knjazevi ühisfirma Baltic East Machine poolt

Использование гендерного подхода при расследовании преступлений, совершаемых женщинами = Gender approach application at investigation of crimes committed by women / Еле

Index Scriptorium Estoniae

Холопова, Елена Николаевна

2017-01-01

Soolise võrdõiguslikkuse rakenduse eripära kriminalistikas ja selle kasutamise põhimõtteid kuritegevuse ennetamiseks, naiste poolt toime pandud kuritegude uurimise teooria ja praktika peamised valdkonnad

O lizingovom finansirovanii tranzitnogo sektora = Lease financing of the transit sector / Marina Vijar

Index Scriptorium Estoniae

Vijar, Marina

2003-01-01

Ülevaade 2002. aasta novembris Hansapanga Grupi, Hansa Capital Grupi ja Euroopa Rekonstruktsiooni- ja Arengupanga (EBRD) poolt Venemaal asutatud ettevõtte Hansa Leasing Russia tegevusest transiitkaubandusettevõtete finantseerimisel

World Bank : Baltic economies should cool down in 2005

Index Scriptorium Estoniae

2005-01-01

Artiklis keskendutakse Maailmapanga poolt läbiviidud uuringu tulemuste analüüsile, mille kohaselt peaks Baltimaades 2005. aastal majanduslik areng aeglustuma. Uuringut teostati Euroopa Liidu uutes liikmesriikides.

Case C-182/15, Proceedings Relating to the Extradition of Aleksei Petruhhin / Filippo Fontanelli

Index Scriptorium Estoniae

Fontanelli, Fillippo

2017-01-01

Euroopa Kohtu lahendist, mis puudutab Venemaa ametiasutuste poolt Läti ametiasutustele saadetud Eesti kodaniku Aleksei Petruhhini väljaandmise taotlust seoses narkootilise aine turustamise süüteoga

Ühe väljasurnud kala lugu Saaremaalt / Tiiu Märss

Index Scriptorium Estoniae

Märss, Tiiu, 1943-

2011-01-01

Saaremaalt Himmistest leitud siluriaegse telodondi Phlebolepis elegans Panderi kivististest ning Himmiste paemurru laastamisest ja üle 3500 kivistunud merelooma väljaveost Ameerikasse 1930nendatel William Patteni poolt

Rahvusvaheline arhitektuuripoliitika seminar Tallinnas : lõpudiskussioon / interv. Triin Ojari

Index Scriptorium Estoniae

2005-01-01

Diskussioon toimus Tallinnas 7. II 2005. a. Eestis on 2002. a. valitsuse poolt heaks kiidetud "Eesti arhitektuuripoliitika" dokument ning sellele järgnev "Arhitektuurivaldkonna tegevuskava 2004-2008" (2004)

Sten Lassmann uurib ja plaadistab Ellerit

Index Scriptorium Estoniae

2011-01-01

Londoni Kuninglikus Muusikaakadeemias õppivast pianistist, tema doktoritööst. Plaadifirma Toccata Classics poolt väljaantavast Heino Elleri klaverimuusika heliplaadist, kavas välja anda seitse heliplaati

Ameerika teismelised on netisõbrad / Tõnu Vare

Index Scriptorium Estoniae

Vare, Tõnu, 1947-

2005-01-01

USA uuringufirma Pew Internet & American Life Project poolt 2005. a. juulis avaldatud uuringu tulemustest Interneti kasutamise kohta 12-17-aastaste noorte seas. Diagrammid: Interneti kasutajad (%) USA-s 2005

Globaalsus + lennundus = Star Alliance? / Ain Hinsberg

Index Scriptorium Estoniae

Hinsberg, Ain

2002-01-01

Erinevad koostöövormid lennufirmade vahel, alliansside teke ja areng maailmas. Maailma juhtivad lennundusalliansid ja nende poolt kaetud riigid ja sihtkohad. Kommenteerib Estonian Airi president Erki Urva

Zwischen Mars und Merkur : Narvaer und Revaler Kaufleute im Handel mit den Niederlanden um 1675 / Enn Küng

Index Scriptorium Estoniae

Küng, Enn, 1963-

2005-01-01

Ülevaade Euroopa poliitilistest suhetest 1660ndatel ja 1670ndatel aastatel. Rootsi kuninga poolt kehtestatud kaubanduskeelust (kehtis 1675-1676) Madalmaadega ja selleteemalisest kirjavahetusest Tallinna ja Narva võimuesindajatega

Elektroonilise informatsiooni kasutamisest / Sirje Virkus

Index Scriptorium Estoniae

Virkus, Sirje, 1956-

1998-01-01

Artiklis on toodud uuringud elektroonilise informatsiooni kasutamisest ja 1994. a. TPÜ infoteaduste õppetooli poolt läbi viidud küsitlus Interneti kasutamisest Tallinna Pedagoogikaülikooli raamatukogus

Avalik huvi ettevõtlusvabaduse piiramise alusena / Arnika Kalbus

Index Scriptorium Estoniae

Kalbus, Arnika

2003-01-01

Avaliku huvi mõistest, haridus- ja teadus-, keskkonna-, kultuuri-, majandus- ja kommunikatsiooni-, põllumajandus-, rahandus-, sise- ja sotsiaalministeeriumi poolt väljastatud tegevuslubadest, tegevuslubade alternatiividest, tegevuslubadega seotud õigusprobleemidest

A field programmable gate array unit for the diagnosis and control of neoclassical tearing modes on MAST

Energy Technology Data Exchange (ETDEWEB)

O' Gorman, T.; Gibson, K. J.; Snape, J. A. [York Plasma Institute, Department of Physics, University of York, York YO10 5DD (United Kingdom); Naylor, G.; Huang, B.; McArdle, G. J.; Scannell, R.; Shibaev, S.; Thomas-Davies, N. [EURATOM/CCFE Fusion Association, Culham Science Centre, Oxfordshire OX14 3DB (United Kingdom)

2012-10-15

A real-time system has been developed to trigger both the MAST Thomson scattering (TS) system and the plasma control system on the phase and amplitude of neoclassical tearing modes (NTMs), extending the capabilities of the original system. This triggering system determines the phase and amplitude of a given NTM using magnetic coils at different toroidal locations. Real-time processing of the raw magnetic data occurs on a low cost field programmable gate array (FPGA) based unit which permits triggering of the TS lasers on specific amplitudes and phases of NTM evolution. The MAST plasma control system can receive a separate trigger from the FPGA unit that initiates a vertical shift of the MAST magnetic axis. Such shifts have fully removed m/n= 2/1 NTMs instabilities on a number of MAST discharges.

Kultuurigenotsiid Eestis : kirjanikud (1940-1953) / Toomas Karjahärm

Index Scriptorium Estoniae

Karjahärm, Toomas, 1944-

2006-01-01

Eesti kunstiintelligentsi tagakiusamisest 1940-1953 Nõukogude ja natsi-Saksamaa okupatsioonivõimude poolt. Lähemalt on vaatluse all literaadid, professionaalsed kirjanikud, kriitikud ja tõlkijad, kes kuulusid kirjanike loomingulistesse liitudesse

Suurbritannia poliitikud on rahvast petnud / David Hathaway ; ref. Hille Simm

Index Scriptorium Estoniae

Hathaway, David

2003-01-01

Ülevaade 26. augustil 2003 ajakirja Eurovision peatoimetaja David Hathaway poolt Tallinnas peetud loengust, teemaks Euroopa Liidu negatiivsed mõjud Suurbritannia majanduslikule arengule ja enesemääramisõigusele

Put k russkim Estonii / Josef Kats

Index Scriptorium Estoniae

Kats, Josef, 1977-

2007-01-01

Eesti Avatud Instituudi ja uuringufirma Saar Poll korraldatud ning Tallinna linna poolt tellitud uurimusest "Rahvussuhted ja integratsiooni perspektiivid Eestis", mis valmis üle-eestilise küsitluse põhjal

Maksuhalduri tõlgendusi väärtpaberitulude maksustamisel : [bakalaureusetöö] / Kerttu Olmann-Mõis ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lasse Lehis

Index Scriptorium Estoniae

Olmann-Mõis, Kerttu

2006-01-01

Väärtpaberitulude maksustamisel maksuhalduri poolt kasutatav praktika, maksuõiguse allikad ja Eesti tulumaksustamise regulatsioon, maksuõiguse üldpõhimõtted, majandusliku tõlgendamise põhimõte, maksuhalduri eelotsused

V Tallinne pustjat metro / Jekaterina Rodina

Index Scriptorium Estoniae

Rodina, Jekaterina

2005-01-01

2010. aastal peaks käiku minema kiirtrammiliin Tallinnas, Prantsusmaa konsultatsioonifirma Systra poolt välja töötatud Tallinna ühistranspordi optimeerimise projekt haarab kogu linna transpordiskeemi

Domik Petra / Jüri Kuuskemaa

Index Scriptorium Estoniae

Kuuskemaa, Jüri, 1942-

2006-01-01

Kunstiajaloolane Jüri Kuuskemaa tutvustab Peeter I majamuuseumi Kadriorus. Maja ajaloost, sisustusest (mööbel, kunstiesemed). Keldriruumis eksponeeritud Salomon Zeltrechti ja tema abiliste poolt tehtud kivibüstidest

Studija prihodit v dom / Jekaterina Golubeva

Index Scriptorium Estoniae

Golubeva, Jekaterina

2004-01-01

Ameerikas XX sajandi 20-ndail aastatel arhitekt Mies van der Rohe poolt projekteeritud esimesest korter-stuudiost (korter ilma tube eraldavate vaheseinteta) ja korter-stuudiod 85 aastat hiljem. Nõuandeid sisustuseks

Tundkem maailma kultuurilugu Amazonasest Mongooliani! / Laur Kiik

Index Scriptorium Estoniae

Kiik, Laur, 1987-

2007-01-01

Lääne-keskselt ajaloolt ja kultuuriloolt tuleks liikuda maailmakeskse ajaloo-, ühiskonna- ja kultuuriõppeni. Noorte sotsiaaldemokraatide poolt korraldatud maailmakultuuri koolitusel "Ilmaviis" esines ka TLÜ rektor Rein Raud

Reading of Beowulf / Ilmar Anvelt

Index Scriptorium Estoniae

Anvelt, Ilmar, 1949-

2013-01-01

Kirjandusfestivali Prima Vista raames toimunud anglo-saksi eepose täies mahus ettelugemisest nii vanainglise keeles kui eestikeelses tõlkes TÜ inglise filoloogia osakonna õppejõudude ja tudengite poolt

Elukutselise võistkonnasportlase õiguslikust seisundist ja õiguste kaitsest : [bakalaureusetöö] / Liina Teras ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

Index Scriptorium Estoniae

Teras, Liina

1999-01-01

Spordisuhete reguleerimisest: seadusandlik, spordisisene, lepinguõiguslik. Võistkonnasportlase õiguslik seisund, mängijaleping - sõlmimine, poolte kohustused, lepingu rikkumine ja lõpetamine, kahju hüvitamine, õigusvaidluste lahendamine ja kohtupraktika

Tervishoiutöötaja kriminaalvastutus ettevaatamatus surma põhjustamises = Healt care providers criminal liability of causing negligent homicide : [bakalaureusetöö] / Urmela Kraas ; Tartu Ülikool, õigusteaduskond ; juhendaja: Dmitri Teplõhh

Index Scriptorium Estoniae

Kraas, Urmela, 1988-

2013-01-01

Tervishoiutöötaja vastutuse statistikast Eestis ja kriminaalvastutuse kohtupraktikast ettevaatamatu surma põhjustamise eest, ettevaatamatu surma põhjustamisest tervishoiutöötaja poolt Eestis, USA-s ja Inglismaal

Villa mägijärve kaldal / Dagmar Reinolt

Index Scriptorium Estoniae

Reinolt, Dagmar

2015-01-01

ARS Projekti poolt rekonstrueeritud villa Šveitsis Lugano linnas, mille uus siselahendus on voolav, moodne ja mitmetahuline. Arhitekt: Rasmus Tamme. Sisearhitektid: Rene Safin ja Eero Jürgenson. Valmimisaasta: 2014

Sotsiaalne vastutus Eesti moodi : firma maksab, omanik võtab aupaiste? / Külliki Tafel, Ruth Alas

Index Scriptorium Estoniae

Tafel, Külliki

2006-01-01

Väljavõtteid intervjuudest, mis viidi läbi Estonian Business Schooli ja Tuleviku-uuringute Instituudi poolt korraldatud sotsiaalse vastutuse uuringu raames. Lisa: EBSi ja Tuleviku-uuringute Instituudi uuring

Portreefotograafia Oscarid. Kuidas neid küll jagada? / Annika Haas ; kommenteerinud Birgit Püve

Index Scriptorium Estoniae

Haas, Annika, 1974-

2016-01-01

Londoni rahvusliku portreegalerii (National Portrait Gallery) poolt 2003. aastal algatatud portreefotokonkursist Taylor Wessing Photographic Portrait Prize (TWPPP). 2015. aasta võidutöö: David Stewart "Viis tüdrukut"

U-Cat Roboterschildkröte aus Estland

Index Scriptorium Estoniae

2014-01-01

Tallinna Ülikooli teadlaste poolt merikilpkonna eeskujul konstrueeritud allveerobotist U-Cat. Konstrueerimisel on peetud silmas sukeldumist laevavrakkidesse. Robot konstrueeriti projekti Arrows (Archaeological Robot Systems for the World's Seas) raames

Mina ka olen Ameerika / Michele Norris

Index Scriptorium Estoniae

Norris, Michele

2016-01-01

Washingtoni uus riiklik afroameerika ajaloo ja kultuuri muuseum ning selle mitmekülgne kollektsioon näitavad afroameeriklaste kannatuste, visaduse ja triumfide isiklikku poolt. Muuseumi peakuraatoriks on Rex Ellis

Rethinking the principle of subsidiarity / Erkki Vedder

Index Scriptorium Estoniae

Vedder, Erkki

2004-01-01

Peipsi Koostöö Keskus oli üks 22 partnerist, kes osales EL-i Activite Citizens Network'i poolt algatatud projektis, mille raames tutvustati horisontaalse subsidiaarsuse printsiipi erinevates riikides

Õlu, Autobahn, Hitler ja saksa keel Eestis / Heiko F. Martens, Maris Saagpakk

Index Scriptorium Estoniae

Martens, Heiko F.

2013-01-01

Saksa keele õppijate osakaalu langusest Eestis. Aastail 2011-2012 korraldati kolmes Balti riigis uuring, selgitamaks asjaolusid, mis mängivad rolli saksa keele õppimise poolt või vastu otsustamisel

Uuring : Eesti autostumisel on Lääne-Euroopaga võrreldes palju arenguruumi

Index Scriptorium Estoniae

2007-01-01

Autostumisest Eestis ja Euroopa Liidu liikmesriikides, Euroopa Komisjoni poolt tellitud Eurobaromeetri uuringu tulemustest. Lisa: 2006. aastal esmaregistreeriti Eestis kokku 74 212 sõiduautot, aasta varem 60 626 sõiduautot.

Decision No. 1, 22 June 1993 : The Constitutional Review Chamber of the National Court of The Republic of Estonia : review of the petition of the President of the Republic, pursuant to § 107 of the Constitution, seeking to declare the National Coat

Index Scriptorium Estoniae

1994-01-01

Riigikohtu lahendi III-4/A-1 (Vabariigi Presidendi poolt põhiseaduse § 107 korras esitatud ettepaneku, tunnistada Riigivapi seadus põhiseadusega vastuolus olevaks, läbivaatamine) tekst inglise keeles

Kuidas me oleme EL poliitika abiga vältinud kvalifitseeritud tööjõu puudust = How have we been avoiding the lack of qualified labour with the help of EU policies? / Erja Lindberg

Index Scriptorium Estoniae

Lindberg, Erja

2006-01-01

Kesk-Uusimaa partnerlusprogrammi projektijuht tutvustab Järvenpää ja Kerava linna ning Tuusula omavalitsuse poolt asutatud Uusimaa Partnerlus projekti, millega 2003. a. liitus ka Nurmijärvi omavalitsus

Hudozhnik namerevalsja võkrasit Monblan

Index Scriptorium Estoniae

2007-01-01

Mont Blanci mäetipu roosaks värvida kavatsenud Tšiili päritolu taani avangardikunstnik Marco Evaristti peatati prantsuse politseinike poolt. Kunstniku kommentaarid kunstiprojektile Mont Blanc Project

Pagunitega kurjategijad : nõukogude sõjaväelaste kriminaalkuritegevus Eestis sõjajärgsetel aastatel / Tiit Noormets

Index Scriptorium Estoniae

Noormets, Tiit, 1959-

2005-01-01

Lisa: Valgamaa NKVD ja NKGB juhtide ettekanne siseasjade rahvakomissar Resevile 7.-8. nov. 1945 Valgas toimunud intsidendi kohta ; Sõjaväelaste poolt sooritatud iseloomulikud kuriteod 1946. aasta I kvartalis

Pokoja net kak net / Evelyn Sepp

Index Scriptorium Estoniae

Sepp, Evelyn, 1972-

2007-01-01

Riigikogu liige loodab, et peale valimisi kaitseminister Jürgen Ligi poolt kokku kutsutud sõjahaudade komisjon ei kiirusta enam oma otsuste tegemisega, millega võiks kaasneda pronkssõduri teisaldamine

Iskusstvo võbrasõvat musor / Dmitri Babitshenko

Index Scriptorium Estoniae

Babitshenko, Dmitri

2007-01-01

Endise tehase "Polümeer" hoones asuvas galeriis Art Container avati grafiti-kunstnike Tõnise ja Jukku poolt maalitud klaastaara-konteinerite fotode näitus "Märka konteinerit". Samanimelisest kunstiprojektist

Portfolio Café oli abiks eneseväljendamisel ja raha teenimisel / Piret Potisepp

Index Scriptorium Estoniae

Potisepp, Piret

2011-01-01

VI Disainifestivali Disainiöö ja Euroopa Innovatsioonifestivali IF... programmi kuulus sel aastal esimest korda Eesti Kunstiakadeemia poolt läbi viidud disainimagistrantide ja noorte disainerite Portfolio Café

Na gorizonte majatshit nekulturnaja avtonomija / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2008-01-01

MTÜ "Vene Kultuuriautonoomia" loomise teemal vene kultuuri olukorrast Eestis. Juri Lotmanist ja filmi "Lotmani maailm" poolt püstitunud küsimustest, ebakindlusest Vene Teatri arengu suhtes ja muust

Kas Eestis on turvaline elada? Ekspertküsitluse tulemused / Iris Pettai

Index Scriptorium Estoniae

Pettai, Iris, 1947-

2005-01-01

Vabariigi Presidendi akadeemilise nõukogu juures tegutseva sise- ja rahvusliku julgeoleku komisjoni poolt läbi viidud küsitlusest Eesti riigi võimalustest kriisiolukordade ennetamiseks ning turvalise elukeskkonna loomiseks

Diabeedibuss liigub külast külla / Marju Past

Index Scriptorium Estoniae

Past, Marju, 1963-

2011-01-01

Diabeediliidu poolt käivitatud projektist avastamaks diabeeti varajases staadiumis. Maakondade väiksemates asulates mõõdetakse erinevaid tervisele olulisi parameetreid ning määratakse vajadusel esialgne ravi

Esindusteenuseid pakub Airline Management

Index Scriptorium Estoniae

2007-01-01

Lennufirmadele ja teistele turismivaldkonna ettevõtetele esindusteenuseid pakkuvast firmast Airline Management OÜ. Firma poolt Eestis esindatud lennufirmade Air Namibia, SN Brussels Airlines ja Flynordic ning hotelligrupi Wyndham lühitutvustus

Valuation of private companies by Estonian private equity and venture capitalists / Priit Sander, Margus Kõomägi

Index Scriptorium Estoniae

Sander, Priit, 1973-

2007-01-01

Eraettevõtete hindamine Eesti era- ja riskiinvestorite poolt. Riskikapitali hinnakujundamise meetodid. Tabelid: Venture capital valuation issues; Venture capital pricing issues and return. Skeem: The venture capital valuation process in Estonia

Politsei pani Itaalia luurajatel CIA abistamise eest käed raudu / Olli Vesala

Index Scriptorium Estoniae

Vesala, Olli

2006-01-01

Itaalia prokurörid käskisid arreteerida kaks kõrget luureametnikku süüdistatuna Milanos CIA poolt terrorismis kahtlustatava islamivaimuliku röövimises kaasaaitamises. Lisa: Terrorismis kahtlustatu

USA uus luuresheff tõhustab spioonivõrku / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2004-01-01

USA Luure Keskagentuuri uueks peadirektoriks saab senati poolt kinnitatud Porter Goss, kelle esimesteks sammudeks uuel ametikohal on luureohvitseride motiveerimine suuremate riskide võtmisele ja globaalse agentide võrgu tõhustamine

Respublikaanide ja sotside pettus Loksal / Ralf R. Parve

Index Scriptorium Estoniae

Parve, Ralf R., 1946-2008

2006-01-01

Loksa linnavolikogu koalitsioon ja Keskerakond pidasid eraldi istungeid. Ebaseaduslike vahenditega valiti libavolikogu poolt valijamees presidendivalimisteks, see osutus õigustühiseks ja nüüd tuleb volikogul valijamees uuesti valida

Decision of the Constitutional Review Division of the National Court of The Republic of Estonia : 18 February 1994 : review of the Petition of the President of the Republic seeking to declare the Service Awards Act in violation of § 107 of the Const

Index Scriptorium Estoniae

1995-01-01

Riigikohtu lahendi III-4/A-3/94 (Vabariigi Presidendi poolt Põhiseaduse § 107 alusel esitatud taotluse tunnistada Teenetemärkide seadus Põhiseadusega vastuolus olevaks, läbivaatamine) tekst inglise keeles

The Kohtla weapon deposit: preliminary results / Ester Oras, Aivar Kriiska

Index Scriptorium Estoniae

Oras, Ester, 1984-

2014-01-01

2013. aasta augustis avastas harrastusdetektorist Mihhail Sadnik muinasaegse raudesemete leiu. Päästekaevamiste käigus tuvastati Eesti suurim rauaaegne raudesemetest koosnev peitvara, mis tunnistati Muinsuskaitseameti poolt 2013. aasta leiuks

Kvaliteedi kindlustamine - väljakutse Eesti kõrgharidusele / Nele Sumberg

Index Scriptorium Estoniae

Sumberg, Nele

2004-01-01

10.-11. mail Tartus toimunud Üliõpilaskondade Liidu poolt korraldatud rahvusvahelisest kõrghariduse kvaliteedi konverentsist, millel esines sõnavõtuga ka EBS-i välissuhete prorektor Nicola Hijlkema

Tarkvara piraatlus arvutimängude näitel : [bakalaureusetöö] / Maksim Barinov ; Tartu Ülikool, õigusteaduskond ; juhendaja: Aleksei Kelli

Index Scriptorium Estoniae

Barinov, Maksim

2010-01-01

Optilise plaadi originaalsuse kontrolli kasutamisest arvutimängude loojate poolt kui ühest piraatluse põhjustest, arvutimängude tehnilisest realiseerimisest kui piraatluse põhjusest, järeldustest ja ettepanekutest

Avatud andmed muudavad ühiskonna paremaks / Indrek Petersoo

Index Scriptorium Estoniae

Petersoo, Indrek

2011-01-01

Riigi poolt kogutavad andmed on kättesaadavad erinevate andmebaaside vahendusel. Riigi eesmärgiks on parandada andmete liikumist ja kasutamist erinevate andmekogude vahel. Lisa: Valitsuse 8 open data printsiipi

The impact of objective characteristics on subjective social position / Kristina Lindemann

Index Scriptorium Estoniae

Lindemann, Kristina

2007-01-01

Subjektiivset sotsiaalset positsiooni mõjutavatest teguritest Eesti ühiskonnas. Tallinna Ülikooli Rahvusvaheliste ja Sotsiaaluuringute Instituudi poolt 2004. aastal läbi viidud uuringu analüüs. Graafik. Tabelid

Best Western - tuntud ja tunnustatud ülemaailmne hotelliketi bränd

Index Scriptorium Estoniae

2012-01-01

1946. aastal Californias M. K. Guertini poolt asutatud Best Western hotelliketist, mis pakub just sõltumatutele hotellipidajatele ühtset turundus- ja müügistrateegiat, brändi- ja teeninduskontseptsiooni

Eesti suurim tuulepark Pakri poolsaarel / Tiit Kallaste, Enn Kareda, Anton Laur, Koidu Tenno

Index Scriptorium Estoniae

2004-01-01

Pakri tuulepark on Eesti esimene suur rahvusvaheline tuuleenergia ühisrakenduse projekt, mille tasuvusuuring ja tuulepargi esimese järgu ehitus on täielikult finantseeritud väliskapitali poolt. Tabelid

Fjodor Berman - Kopli tööstushiiu peremees / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2003-01-01

Äripäeva toimetuse poolt aasta ärimeheks valitud Balti Laevaremonditehase juhist Fjodor Bermanist. Fjodor Berimani CV. Kommenteerib Oliver Kruuda. Diagramm: BLRT Grupi tegevusalad. BLRT Grupi aktsiate jaotus protsentides

Menetlejate küsitlemistehnikad : alla 14-aastaste laste ülekuulamisprotokollide analüüs / Kristjan Kask

Index Scriptorium Estoniae

Kask, Kristjan, 1980-

2010-01-01

Alla 14-aastaste laste kohtueelse ülekuulamise videosalvestiste analüüsist. Ülevaade põhineb Justiitsministeeriumi poolt 2009. aastal läbi viidud uurimisprojektil "Alaealiste ülekuulamine kriminaalmenetluses". Tabelid

2003. aasta logistikateo tegi DFDC Transport / Rivo Sarapik

Index Scriptorium Estoniae

Sarapik, Rivo, 1981-

2004-01-01

Eesti Konverentsikeskuse ja Eesti Logistikaühingu poolt korraldatava konkursi Logistikategu 2003 tulemustest. Lisa: Logistikategu 2003 Suur Auhind - DFDC Transport AS. Vt. samas: Suur auhind: DFDC Transport - uus logistikakeskus Laagris

Tehnikaülikooli teadurid teevad mikrokiipide vallas ajalugu / Urmas Tooming

Index Scriptorium Estoniae

Tooming, Urmas, 1954-

2009-01-01

Euroopa Komisjon eraldas Tallinna Tehnikaülikooli arvutitehnika instituudi poolt juhitavale uurimisprojektile Diamond ligi 45 miljonit krooni. Projekti käigus uuritakse, kuidas mikrokiipide tootmisel tekkivaid vigu avastada ja parandada

Учение ТТУ творят историю в производстве микрочипов / Урмас Тооминг

Index Scriptorium Estoniae

Тооминг, Урмас, 1954-

2009-01-01

Euroopa Komisjon eraldas Tallinna Tehnikaülikooli arvutitehnika instituudi poolt juhitavale uurimisprojektile Diamond ligi 45 miljonit krooni. Projekti käigus uuritakse, kuidas mikrokiipide tootmisel tekkivaid vigu avastada ja parandada

Iraagist naasnud Leo Kunnas : sõja nimi on sõda / Leo Kunnas ; interv. Enno Tammer

Index Scriptorium Estoniae

Kunnas, Leo, 1967-

2005-01-01

Iraagist naasnud kolonelleitnant vastab küsimustele, mis puudutavad Iraagi-missiooni ja selle pikendamist, Eesti kaitseväelaste osalemist missioonil ning Eesti riigipiiri rikkumisi Vene sõjalennukite poolt. Lisa: Kiirarvamus

Three models of integration and the Estonian/Russian reality / David D. Laitin

Index Scriptorium Estoniae

Laitin, David D.

2003-01-01

Autor kirjeldab kolme 2000. aastal vastu võetud Eesti riiklikus integratsiooniprogrammis sisalduvat kolme integratsiooni mudelit ja pakub omalt poolt välja neljanda, milles kaks integratsiooniprotsessi toimuvad samaaegselt. Lisad. Tabelid

Genotsiid ja apartheid okupeeritud Eestis. [1.-3. osa] / Enn Sarv

Index Scriptorium Estoniae

Sarv, Enn, 1921-2008

1997-01-01

Peatükk raamatust "Õigluse vastu ei saa ükski". NSVLi poolt eestlaste kallal toimepandud inimsusevastased kuriteod. Inimkaotused, raamatute hävitamine. Sõjakuriteod ja nende eest karistamise võimalused

Eesti ettevõtjad on Euroopas esindatud / Urmas Arumäe

Index Scriptorium Estoniae

Arumäe, Urmas, 1957-, advokaat

2005-01-01

Euroopas väikese ja keskmise suurusega ettevõtjate huve esindavast ja kaitsvast survegrupist SME Union. 19. jaanuaril Budapestis SME Union'i allstruktuuri SME Energy poolt korraldatud energeetika-alasest konverentsist

Radar - interaktiivne kultuurilooline kaart / Tõnno Jonuks, Priit Lätti

Index Scriptorium Estoniae

Jonuks, Tõnno

2006-01-01

Radar on digitaalne Eesti kaart, mis kajastab ümbritseva maastiku kujutamist ja mõtestamist elanike poolt. Pilootprojektina alustati Eesti Kirjandusmuuseumi folkloristika osakonnas Lääne-Viru maakonna kaardistamist 2003. a.

The Finlandisation of Karelia and the Russification of Finland as Reflected in the Russian Press at the Beginning of the 20th Century / Maxim Pulkin

Index Scriptorium Estoniae

Pulkin, Maxim, 1968-

2004-01-01

Vene võimude ja vaimulikkonna võitlusest soome-meelsete ideede levitamise vastu Karjalas 20. sajandi alguses. Karjalaste assimileerimiseks kavandatud meetmetest. Nikolai II poolt 1914. aastal heaks kiidetud Soome venestamise plaanist

Lõbusa eeskavaga Oktoberfest Lakewoodis / Priit Parming ; fotod: Liisa-Mai Karuks

Index Scriptorium Estoniae

Parming, Priit

2012-01-01

22. septembril kogunes paarisajaliikmeline eestlaste, lätlaste ja leedulaste pere Lakewoodi Eesti Ühingu maa-alale, nautima ilusat ilma ja hubast meeleolu ühingu poolt korraldatud Balti kallakuga Oktoberfestil

Noorpianist pani "tundmatu" Elleri plaadile / Sten Lassmann ; intervjueerinud Mart Niineste

Index Scriptorium Estoniae

Lassmann, Sten, 1982-

2011-01-01

Vestlus pianistiga Londoni Kuninglikus Muusikaakadeemias õppiva pianistiga, tema doktoritööst. Plaadifirma Toccata Classics poolt väljaantavast Heino Elleri klaverimuusika heliplaadist, kavas välja anda seitse heliplaati

Будущее государство уже признали провалившимся / Эвелин Калдоя

Index Scriptorium Estoniae

Калдоя, Эвелин, 1980-

2011-01-01

Washingtonis baseeruva valitsusvälise uuringukeskuse Rahufond poolt koostatud läbikukkunud riikide tabelist. Tabelit juhib Somaalia, Eesti on tabelis 140 kohal. Maailma kõige ohtlikumad piirialad Foreign Policy hinnangul

Tulevane riik tunnistati läbikukkunuks / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2011-01-01

Washingtonis baseeruva valitsusvälise uuringukeskuse Rahufond poolt koostatud läbikukkunud riikide tabelist. Tabelit juhib Somaalia, Eesti on tabelis 140 kohal. Maailma kõige ohtlikumad piirialad Foreign Policy hinnangul

Kabja tervishoiu koolitus / Sanna Turu

Index Scriptorium Estoniae

Turu, Sanna

2013-01-01

Eesti Raskeveohobuse Seltsi poolt 25. mail Raplamaal Piibelehe Puhkekemajas korraldatud koolitusest, kus hobuveterinaar Triin Tohver ja professionaalne sepp Stephan Ernest Saksamaalt tegid põhjaliku ülevaate hobuse kabja tervishoiu teemadel

Statue svobodõ - 120 / Grigori Ivanov

Index Scriptorium Estoniae

Ivanov, Grigori

2004-01-01

Ameerika Vabadussamba saamisest. Autoriks oli noor Elsassi arhitekt Frederic-Auguste Bartholdi. Metallkarkassi konstrueeris insener Gustave Eiffel. Kuju sai valmis ja kingiti Prantsusmaa poolt Ameerikale 1884. a. Vabadussammas avati 1886. a.

Tunnustame tõenduspõhise õendusabi edendajaid / Ester Öpik, Ilme Aro

Index Scriptorium Estoniae

Öpik, Ester

2014-01-01

Tunnustati meditsiiniõdesid Tiina Freimanni, Reet Urbanit, Marika Asbergi, Tiina Tõemetsa, Kersti Viitkarit ja Ireen Bruusi Eesti Õdede Liidu poolt 2011. aastani kaitstud õendusteaduslike uurimistööde eest

Weroli pankrotiprotsessi oleks saanud vältida / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2005-01-01

Aktsiaseltside Werol Tehased ja Biodiesel vahel sõlmitud lepingutest, mis on viinud Jõgeva maakohtu poolt AS-i Werol Tehased vastu algatatud pankrotimenetluseni. Vt. samas: Werol ei ole ajutise pankrotihalduriga rahul

President Mugabe üritab valimissohiga võimule jääda / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

Zimbabwe opositsioon kuulutas end valimistel võitjaks, väidetavalt kavatseb aga valitsus teatada, et praeguse riigipea Robert Mugabe poolt hääletas 52% valijaist. Mugabe valitsemisajast, Zimbabwe praegusest olukorrast

Libavaida sugrusida uherles ja vurles kehus* / Maria Ulfsak-Šeripova

Index Scriptorium Estoniae

Ulfsak-Šeripova, Maria, 1981-

2010-01-01

Tim Burtoni filmist "Alice Imedemaal" (USA 2010), stsenarist Linda Woolverton, peaosades Mia Wasikowska, Johnny Depp. Lisaks kaks arvamust "3D poolt", autor Mann Jõgeda ja "3D vastu", autor Margit Tõnson

Ühistu aruandlust ja infovahetust pidage internetis / Indrek Kald

Index Scriptorium Estoniae

Kald, Indrek, 1974-

2004-01-01

Autor tutvustab AS-i Spin TEK poolt loodud e-Reeni nimelist tarkvara korteriühistute raamatupidamise lihtsustamiseks. Kommenteerib Peka Ringo. Vt. samas: E-hooldusraamat jõudis Eesti turule juba aasta alguses

Poliitiline toetus ja võimu legitiimsus : Eesti elanikkonna poliitilisest meelsusest 1999. aasta lõpul / Liina Kirsipuu

Index Scriptorium Estoniae

Kirsipuu, Liina

2000-01-01

Riigikogu Kantselei poolt tellitud avaliku arvamuse uuringust "Riik ja rahvas" (oktoober 1999) kodanike rahulolu Eesti poliitilise korralduse eri aspektidega analüüs. Summary: Political Support and legitimacy of the power

Pillide kuningannal oma fond / Eda Liiväär

Index Scriptorium Estoniae

Liiväär, Eda

2006-01-01

Eesti Rahvuskultuuri Fondi allfondi - Eesti Klaverifondi avamise tähistamisest disainklaverite näituse ja Rein Rannapi kontserdiga 8. juunil Viru keskuses. OÜ Reval Piano poolt loodud sihtasutusest Eesti Rahvuslik Klaverimuuseum

Eesti Picasso / Jüri Muttika

Index Scriptorium Estoniae

Muttika, Jüri

2006-01-01

Mart Kivastiku kunstniketriloogia kolmandas osas "Kits viiuli ja õngega" on peategelane Elmar Kits. Näidendi aluseks on kunstniku päevikud, antud tütre Saskia Kasemaa poolt. Harry Liivranna kommentaar

Endine linnaametnik saab pealinna suurpargi golfiväljakute rajamiseks / Silva Männik

Index Scriptorium Estoniae

Männik, Silva, 1974-

2004-01-01

Endise linnaametniku Tarmo Valgepea poolt juhitav MTÜ Eesti Golfi Liit sai Pirital asuva ligi 30 ha suuruse Lillepi pargi hoonestusõiguse sotsiaalmaa maksustamise hinnaga. Kaart: Tallinna suuruselt teine park muutub golfikeskuseks

Tänavatants on jõudnud Põlvasse / Joel Juht ; interv. Kadri Luik

Index Scriptorium Estoniae

Juht, Joel

2006-01-01

2. veebr. toimus Põlva Tervisekeskuse tantsusaalis esimest korda JJ-Street Dance Company poolt korraldatud tänavatantsu treening, mida viisid läbi tantsustuudio looja Joel Juht ja treener Britta Gassmann

Tööandja kulutused töötajatele, 2000 / Mare Kusma, Õie Palmre

Index Scriptorium Estoniae

Kusma, Mare

2002-01-01

Statistikaameti poolt esmakordselt korraldatud vaatluse "Tööandja kulutused töötajatele" metoodika ja tulemused. Summary: Labour costs, 2000. Tööjõukuludega seotud mõistete definitsioonid. Tabelid ja diagrammid

Constitutional pluralism as mutually assured discretion: The Court of Justice, the German Federal Constitutional Court, and the ECB / Matthias Goldmann

Index Scriptorium Estoniae

Goldmann, Matthias

2016-01-01

Euroopa Kohtu poolt Gauweiler'i kaasuses rakendatud ülevaate standardist, mis puudutasid Euroopa Keskpana (ECB) rahalisi otsetehinguid (OMT). Euroopa Kohtu vaatenurgast ratsionaalsusele ja proportsionaalsusele, mis kannab suurt potentsiaali Euroopa Liidu pluralismile

IIZI pääses infovarguse kriminaalasjast puhtalt

Index Scriptorium Estoniae

2009-01-01

Liikluskindlustuse Fondi poolt IIZI Kindlustusmaakler AS-i vastu esitatud süüdistused massilistes ebaseaduslikes infopäringutes fondi andmebaasidest ning ERGO süüdistused kliendiandmete varguses osutusid põhjendamatuteks

Takistusriba avalikule teabele / Ivar Tallo

Index Scriptorium Estoniae

Tallo, Ivar, 1964-

2004-01-01

Autori arvates on riiklike registrite poolt jagatava teabe eest tasu võtmine avaliku teabe seadusega vastuolus ega vasta kaasaegsetele infotehnoloogilistele lahendustele. Vastuseks vt.Viljar Peep. Registritest 6.aug. Postimees lk. 10

Muusika tiibadel üha kõrgemale / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2006-01-01

Anu Tali tööst Põhjamaade Sümfooniaorkestriga, orkestri kümnendast hooajast. Saksa telekanali Arte poolt salvestatavast filmist, mis kõneleb Anu Talist. 17. mail Estonia kontserdisaalis toimuvast kontserdist

Beevor receives Estonian State decoration

Index Scriptorium Estoniae

2008-01-01

Eesti suursaadik Suurbritannias Margus Laidre andis 2. juunil 2008 Londonis Suurbritannia ajaloolasele Antony James Beevorile üle talle president Toomas Hendrik Ilvese poolt annetatud Maarjamaa Risti III klassi teenetemärgi

Estonian Airi uued soodsad pakkumised

Index Scriptorium Estoniae

2010-01-01

Estonian Airi kodulehelt on võimalik osta lennupileteid koostööpartnerite poolt pakutavatele mandritevahelistele lendudele ning broneerida internetis hotellituba Euroopa suurima hotelli broneerimise teenust pakkuva ettevõtte Booking.com kaudu

Autoralli MM-sarja ootab ees vaheaasta / Ivo Dobkevitš ; fotod Karli Saul

Index Scriptorium Estoniae

Dobkevitsch, Ivo, 1973-

2009-01-01

Tehasetiimide majandusraskustest ja vähesest huvist autoralli MM-sarja vastu 2009. aastal ning FIA poolt kehtestatavatest tehnilistest muudatustest 2010. aastal. Samas: Urmo Aava hooaega vahele jätta ei kavatse

Britid on tüdinud konveierpopist. Punklegend Velikije Luki tähistab juubelit

Index Scriptorium Estoniae

2002-01-01

Raadiojaama Virgin Radio poolt 26. ja 27. okt. korraldatud küsitlusest. 9. nov. klubis Zellulooz toimuvast ansambli Velikije Luki kontserdist ja 1. nov. ilmunud ansambli esimesest heliplaadist "Tallinn põleb"

Kolm võimalust, kolm kontrasti / Tiiu Levald

Index Scriptorium Estoniae

Levald, Tiiu, 1940-

2009-01-01

Saaremaa ooperipäevadel Soome Kammerooperi ja Läti Rahvusooperi poolt esitatud kolmest ooperist - Ilkka Kuusisto "Vabaduse vang - Ryti, Risto, nr 236/46", R. Wagneri "Lendav Hollandlane" ja C. Puccini "Turandot"

Rahvusvahelise Tööorganisatsiooni konventsioonide ratifitseerimisest Eestis : [bakalaureusetöö] / Merle Muda ; Tartu Ülikool, õigusteaduskond ; juhendaja: Inge-Maret Orgo

Index Scriptorium Estoniae

Muda, Merle, 1972-

1994-01-01

Rahvusvahelise Tööorganisatsiooni (ILO) ajalooline areng, struktuur, aktid; ülevaade Eesti Vabariigi poolt enne 1940. a. ratifitseeritud ILO konventsioonidest; EV seadusandluse vastavusest pärast ILO-ga taasühinemist

Rakendusuuringute ja analüüside tellimine valitsusasutustes 1999-2001 : teel teadmistepõhisema poliitika, õigusloome ja avaliku halduse poole / Aare Kasemets

Index Scriptorium Estoniae

Kasemets, Aare, 1963-

2002-01-01

Ülevaade Riigikogu Toimetiste poolt korraldatud parlamendiuuringust ja selle eesmärkidest, valitsusasutustes aastail 1999-2001 tellitud uuringute arvust ja kuludest ning võimalikest lahendusideedest uuringute tellimise korraldusega seonduvatele probleemidele. Tabelid

Ühistutel on hoogu / Aarne Liiders

Index Scriptorium Estoniae

Liiders, Aarne

2004-01-01

Statistikat metsaühistute tegevuse kohta, toetudes erametsaliidu poolt ühistute seas korraldatud küsitluse tulemustele. Parimateks ühistuteks valiti Põlva metsaselts, Viru-Lemmu metsaselts ja Rakvere metsaühistu

Leibkonna sissetulekute dünaamika ja tüpoloogia = Dynamics and typology of household incomes / Aivi Themas

Index Scriptorium Estoniae

Themas, Aivi

2005-01-01

Uurimus leibkondade sissetulekute dünaamika ja tüpoloogia kohta, mis põhineb ajavahemikel 1997-1999 ja 2000-2003 Statistikaameti poolt läbiviidud leibkonna eelarve uuringu tulemustel. Tabelid. Skeemid

Eesti, eksiil ja Välis-Eesti : väike mentaliteedilugu / Jaan Undusk

Index Scriptorium Estoniae

Undusk, Jaan, 1958-

2008-01-01

Artiklis on lk. 2274 juttu ka raadiojaama Vaba Euroopa Eesti toimetuse direktori Toomas Hendrik Ilvese poolt 1988. a. väliseesti kirjanduse konverentsil peetud ettekandest teemal "Väliseesti kirjanduse mõistest"

ÜRO Lastefond toetab Memme Musi eest võitlejaid / Sirje Pärismaa

Index Scriptorium Estoniae

Pärismaa, Sirje, 1958-

2003-01-01

Riigikogu liige, UNICEF-i Eesti president Elle Kull ning haridus- ja teadusministeeriumi järelevalvetalituse peainspektor Tiina Peterson kohtusid Räpina vallavanema Inge Hirmoga, kes on lasteaia Memme Musi sulgemise poolt

KIK-i toetused aastal 2003 : [keskkonnamajandusele] / Heiko Põdersalu

Index Scriptorium Estoniae

Põdersalu, Heiko

2003-01-01

2003. aastal SA Keskkonnainvesteeringute Keskus poolt rahastatavad veekaitseprojektid, jäätmekäitluse, kalanduse, looduskaitse, keskkonnateadlikkuse, metsanduse, välisõhukaitse, maapõue, jahinduse ja tehnika programmid. Nõuandeid toetuse taotlejatele.

U.S. must support Estonia and other targets of Russian aggression

Index Scriptorium Estoniae

2007-01-01

Ühendatud Balti Ameerika Komitee (JBANC) toetab eestlaste otsust nõukogude monumendi ehk nn. pronkssõduri teisaldamiseks ja nõuab tungivalt sedasama väljendada ka Ameerika Administratsiooni ja Kongressi poolt

Kui Liisa kirjutas kirja... / Ulrike Plath, Kaarel Vanamölder

Index Scriptorium Estoniae

Plath, Ulrike, 1972-

2016-01-01

Liisa Pulsti elusaatusest, maakogukonnast pärit vallasemast, kes andis oma kolm last lastekodusse ning kes hiljem Riia baltisaksa perekonnas muutus armastatud perekonnaliikmeks. Artikkel tutvustab Liisa poolt 1946. aastal kirjutatud kirja

Rõõmsama homse nimel...

Index Scriptorium Estoniae

2005-01-01

2005. a. alguses Stockholm School of Economics in Riga, Eesti Õdede Liidu ja AS Resta Eesti poolt korraldatud Eesti õdede rahulolu-uuringust "Rõõmsama homse nimel...". Statistilised tabelid ja diagrammid

Puuetega inimeste õiguste konventsioonist / Monika Haukanõmm

Index Scriptorium Estoniae

Haukanõmm, Monika, 1972-

2007-01-01

25. sept. 2007 Eesti poolt allkirjastatud ÜRO puuetega inimeste õiguste konventsioonist, mis kohustab kaitsma puuetega inimeste õigusi, kaotama igasugune diskrimineerimine ning edendama nende õigusi hariduse, tervise, sotsiaal- ja muudes valdkondades

Kaitseväe üle teostatava demokraatliku tsiviilkontrolli teostamine Eesti Vabariigis : [magistritöö] / Aive Karing ; Akadeemia Nord, õigusteaduskond ; juhendaja: Igor Gräzin

Index Scriptorium Estoniae

Karing, Aive

2007-01-01

Kaitseväe üle teostatava demokraatliku tsiviilkontrolli teoreetilised alused, vajalik seadusandlik baas, täitev- ja seadusandliku võimu poolt teostatav tsiviilkontroll Eestis, ühiskond kui abivahend edukaks demokraatlikuks tsiviilkontrolliks

Emast lahutamine rikub šimpansi elu

Index Scriptorium Estoniae

2014-01-01

Emory ülikooli primatoloogid ja loomapsühholoogid eesotsas Stephen Rossiga uurisid kuidas sulanduvad emast võõrutatud ja inimeste poolt üleskasvatatud, kuid taas oma liigikaaslaste sekka sattunud šimpansside

Teemandiärimees nõuab Eestilt 25 miljonit krooni / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2004-01-01

Iisraeli kodanik Uri Marty esitas Tallinna linnakohtule kahjunõude, seses politsei poolt 2001. aastal aluseltult vahi all hoidmisega, mille tõttu ta olevat kaotanud suurt kasumit tõotanud teemandiäri

Accountability and transparency of financial sector supervision / Pall Gunnar Palsson

Index Scriptorium Estoniae

Palsson, Pall Gunnar

2001-01-01

Finantsjärelvalve üheks oluliseks tingimuseks on läbipaistvus. Rahvusvahelise Valuutafondi poolt vastu võetud raha- ja rahanduspoliitika heade tavade koodeksist. Ülevaade Islandi finantsinspektsiooni töökorraldusest

Eesti Halmas ja Halma Eestis / Mart Siilmann

Index Scriptorium Estoniae

Siilmann, Mart

2008-01-01

Kesk- ja Ida-Euroopa kirjanduskeskuste poolt loodud loomemajade võrgustikust Halma, kuhu kuulub ka Eesti Kirjanike Liidu Käsmu maja. Esimeseks külaliseks Käsmus oli austria kirjanik Richard Obermayr

On see kultuur või majandus? / Ülari Alamets ; intervjueerinud Signe Kalberg

Index Scriptorium Estoniae

Alamets, Ülari, 1967-

2010-01-01

Ettevõtluse Arendamise Sihtasutuse juhatuse esimees Ülari Alamets loomemajandusest, sellega tegelevatest keskustest, loomeettevõtete toetamisest EAS-i poolt, loomeinkubaatorite toetamise eesmärgist. Loetletud loomemajanduse valdkonnad, andmeid Eesti loomemajanduse kohta

Film "Bushizmõ" : lutshije perlõ presidenta

Index Scriptorium Estoniae

2004-01-01

Elisabeth Reederi dokumentaalfilm USA presidendi Georg W. Bushi parimatest ütlustest "Bushisms". Lisaks semiootiku ja kirjaniku U. Eco poolt kogutud lauseid: "Pisatel Umberto Eko sobral znamenitõje võskazõvanija Busha"

... I kozhevennõi ressurss / Jevgeni Ashihmin

Index Scriptorium Estoniae

Ashihmin, Jevgeni

2005-01-01

Kommentaariks ajakirjanduses ilmunud infole president Arnold Rüütli poolt Vladimir Putinile tehtud ettepanekutest koostööks Narva uue silla ehitusel ning tööpuuduse leevendamiseks venekeelse kogukonna hulgas

Kaasomand : korterelamu korrashoiu probleemid / Roode Liias

Index Scriptorium Estoniae

Liias, Roode, 1953-

2003-01-01

ÜRO Euroopa Majanduskomisjoni ekspertide poolt koostatud juhendmaterjalist ühistute töö korraldamiseks Kesk- ja Ida-Euroopa riikides ("Guidelines on condominium ownership of housing for countries in transition." UN; 2003)

Kas madonnale disainitud dress lõpetas prügikastis? / Kais Allkivi, Katrin Pauts

Index Scriptorium Estoniae

Allkivi, Kais

2009-01-01

Viru keskuse Bastioni poes tulevad müügile 25 rahvusmustriga dressi, mis on peaaegu identsed esileedi Evelin Ilvese palvel Bastioni moedisaineri Merike Pääro poolt Madonnale disainitud spordirõivastega

GAZ - slishkom vremennaja alternativa / Roman Vikulov

Index Scriptorium Estoniae

Vikulov, Roman

2005-01-01

Narva linna küttekomisjoni poolt organiseeritud seminarist, kus osales ka Põhjamaade juhtivasse energeetikakompaniisse kuuluva kontserni Fortum Termest arengudirektor Kaido-Paul Bõstrov ja Vene Föderatsiooni majandusministeeriumi riiklik ekspert, akadeemik Vladimir Borovkov

Linnud sõjas / Allan Valge

Index Scriptorium Estoniae

Valge, Allan

2005-01-01

Täispikk arvutianimatsioon "Valiant" : stsenarist George Webster : režissöör Gary Chapman : produtsent John Williams : Suurbritannia 2005. Lisatud Jaan Ruusi poolt kogutud väljavõtteid arvustustest inglise meedias

Põlvkondade kasvatuslikud uskumused heast isast / Edda Kaimre

Index Scriptorium Estoniae

Kaimre, Edda

2000-01-01

Artiklis antakse ülevaade kolme põlvkonna poolt heale isale omistatud tunnustest. Toetutakse 1996.-1999. aastal intervjuumeetodil kogutud materjalile kasvatusalaste uskumuste ja tõekspidamiste kohta, mis sisaldab ka hea isa omaduste loetelu

Moraalset lõivu maksmata on raske äri ajada / Priit Jõgi

Index Scriptorium Estoniae

Jõgi, Priit, 1970-

2003-01-01

Autor arutleb ettevõtjate ning poliitikute sidemete üle Eestis ning leiab, et parteide toetamisele ettevõtete poolt tuleks seada teatavad piirangud, parteide rahastamise keelamise asemel tuleks see muuta läbipaistvamaks.

Küsimus pole MRP-s, vaid agressioonis / Enn Soovik

Index Scriptorium Estoniae

Soovik, Enn, 1933-2010

2005-01-01

Autor leiab, et on vajalik esitada Venemaale pretensioon Nõukogude Liidu poolt Eesti vastu 1939/40 toime pandud agressiooni ja selle järelmite suhtes ning mitte laskuda MRP-ga seotud viljatusse vaidlusse

Rotshild vernul Rossii dotsh Pavla I / Anna Selivanova

Index Scriptorium Estoniae

Selivanova, Anna

2003-01-01

Vene Muuseumi poolt 1941. a. koostatud rändnäituse "Vene maalikunsti arengu põhietapid" saatusest. Fjodor Bognevski "Suurvürstinna Aleksandra Pavlovna portree" ja Orest Kiprenski "Pjotr Basini portree" tagasisaamislood

Afganistan ootab sõpru Eestist / Maari Ross ; intervjueerinud Mari Kodres

Index Scriptorium Estoniae

Ross, Maari

2010-01-01

Jaan Tõnissoni Instituudi poolt 2009. a. algatatud projektist, mille eesmärgiks on tutvustada Afganistani Eestis ja luua kontakte kahe riigi koolide vahel. Lisa. Afganistanist endale sõpruskooli leidnud Eesti koolide nimestik

Arutelu Euroopa Liiduga ühinemisest jõuab lõpule / Üllas Linder

Index Scriptorium Estoniae

Linder, Üllas, 1953-

2003-01-01

Kokkuvõtteid 4. septembril 2003 Valgas korraldatud seminarist "14. septembri rahvahääletuse poolt ja vastu", kus osalesid ka Valga linnapea Margus Lepik, rahandusminister Tõnis Palts ja Riigikogu liige Marko Mihkelson

Kuidas kõrgemale ohvitserile ettekannet teha / James Stavridis

Index Scriptorium Estoniae

Stavridis, James, 1955-

2013-01-01

Endine NATO Euroopa liitlasvägede ülemjuhataja jagab nõuandeid mõjusa ja konstruktiivse ettekande kirjutamiseks ja selle esitlemiseks. Lisatud foto, kus kujutatud James Stavridise autasustamist president Toomas Hendrik Ilvese poolt

Ajujahi võitjad selgunud / Mari Sarv

Index Scriptorium Estoniae

Sarv, Mari, 1978-

2009-01-01

Eesti Ettevõtluse Arendamise Sihtasutuse poolt korraldatud äriplaanide võistluse Ajujaht 2009 kolm parimat võistkonda olid Grofish (kalakasvatuse kulude optimeerimine), ReUse Republic (taaskasutustoodangu tootmine) ning Optimist (puidust kiirkaatrite tootmine)

Seaduslikkus taktikaliste eranditeta / Rein Org

Index Scriptorium Estoniae

Org, Rein

2005-01-01

Sotsiaaldemokraatliku Erakonna peasekretär kritiseerib Reformierakonna ja Keskerakonna poolt sõnavabaduse kaitsmiseks algatatud välireklaamikampaaniat, millega püütakse mõjutada õiguskantsleri hinnangut poliitilist välireklaami keelustavale seadusemuudatusele

TÜ vilistlane ja polaaruurija Herman Walter / Erki Tammiksaar

Index Scriptorium Estoniae

Tammiksaar, Erki, 1969-

2011-01-01

Eduard Gustav von Tolli poolt juhitud polaarekspeditsioonil 1901. aastal surnud ja Kotelnõi saarele maetud arsti Herman Walteri säilmete ümbermatmisest ning tema isiklike esemete annetamisest Tartu Ülikooli Ajaloomuuseumile

Lasteaiaõpetaja roll laste agressiivse käitumise vähendamisel / Katrin Taurus, Lii Lilleoja

Index Scriptorium Estoniae

Taurus, Katrin

2015-01-01

Tallinna lasteaiaõpetajate seas läbi viidud uurimusest selgitamaks välja 2-7-aastaste laste agressiivse käitumise tekkepõhjused ning õpetajate poolt kasutatavad abistamismeetodid selle vähendamiseks

Rattaretk 2010 - Kuidas elad, Vooremaa? / koostanud Vello Keppart ja Helen Arusoo

Index Scriptorium Estoniae

2010-01-01

Eesti Roheline Liikumise MTÜ Roheliste rattaretked poolt 7.-9. mail 2010 korraldatava 21. rattaretke "Kuidas elad, Vooremaa?" teekonna ja vaatamisväärsuste tutvustus. Artiklit illustreerib retke kaart ja päevakava

Hella hingega karmid naised / Krista Kaer

Index Scriptorium Estoniae

Kaer, Krista

1996-01-01

Tänapäeva kriminaalromaani inglise ja ameerika autoritest (Dame Phyllis Dorothy James, Joan Smith, Lynda La Plante (inglise); Sara Paretsky, Sue Grafton, Patricia Cornwell (ameerika) ja nende poolt loodud naisdetektiivi kujudest

Uued riigihankedirektiivid: kas revolutsioon või redaktsioon? / Kadri Härginen, Mari Ann Simovart

Index Scriptorium Estoniae

Härginen, Kadri

2013-01-01

Euroopa Komisjoni poolt 2011. aastal avaldatud uute riigihankedirektiivide ettepanekutest (KOM (2011) 895, 896 ja 897). Pakkuja hankest kõrvaldamisest, pakkuja isikut iseloomustavatest andmetest, hankija otsemaksetest alltöövõtjale, hankelepingute regulatsioonist

Borets za koku prazdnujet pobedu

Index Scriptorium Estoniae

2005-01-01

Boliivias 18. detsembril toimunud presidendivalimised võitis vasakradikaalse liikumise juht, endine kokafarmerite liider Evo Morales, kelle poolt hääletas 50,8 kuni 51,1 protsenti valijatest. Evo Moralese poliitilisest tegevusest

Lithuanians lead way to the EU

Index Scriptorium Estoniae

2003-01-01

Leedus toimunud euroreferendumil hääletas 91% osalenutest EL-iga liitumise poolt. Eesti ja Läti EL-i pooldajate hinnangul avaldab see positiivset mõju referendumi tulemustele ka teistes Balti riikides

"Kus oleme olnud, kuhu läheme" : USA-sse emigreerunud rahvusgruppide dokumenteerimise seminar ja konverents IHRC-keskuses 12. - 14. mail / Airi Vaga

Index Scriptorium Estoniae

Vaga, Airi, 1940-

2005-01-01

Immigration History and Research Center´i (IHRC) ja Minnesota ülikooli poolt korraldatud loengutest, seminaridest ja vastuvõttudest. Eesti Arhiiv Ühendriikides saatis 2003. aastal suure osa oma kogudest IHRC-sse

Kaos ja kord abstraktses kunstis / Vappu Thurlow

Index Scriptorium Estoniae

Thurlow, Vappu, 1960-

2005-01-01

Inglise füüsik Richard Taylor Jackson Pollocki maalidest. Kaose poolt mahajäetud mustritest ehk fraktaalidest. Siim Tanel Annuse reljeefmaalid, Andrus Rõugu abstraktsed vormid. Näitus "Pidulikud kontseptsioonid" Estonia Kontserdisaalis

Eestile väljamakstud ELi toetused ületavad Kesk- ja Ida-Euroopa keskmist / Triin Värav

Index Scriptorium Estoniae

Värav, Triin

2011-01-01

KPMG Ungari kontori poolt läbiviidud uuringu kokkuvõte "EU Funds in Central and Eastern Europe - Progress report 2007-10" annab ülevaate Kesk- ja Ida-Euroopa rahastamisvahenditest aastateks 2007-2013

Hollandi Heineken võib Saksa õlletootja Krombacheri üle võtta / Katri Soe-Suren

Index Scriptorium Estoniae

Soe-Suren, Katri

2008-01-01

Financial Times Deutschland andmetel plaanib Hollandi Heinekeni kontsern Saksa õlletootja Krombacheri ülevõtmist, Heinekeni sunnib laienema USA päritolu Anheuser-Buschi ülevõtmine InBevi poolt juuli keskpaigas. Lisa

Kogda iskusstvo imitirujet zhizn

Index Scriptorium Estoniae

2006-01-01

Lee Strasbergi poolt populariseeritud stanislavskilik "meetodnäitlemine" filmides "Veepiiril", "Kelm", "Kaevuri tütar", "Bridget Jonesi päevik", "Carrie", "Raevunud härg", "Maratoonar", "Aviaator", "Hullusärk", "Pianist" jt.

Vene Sherlock Holmes kirjutab muinasjutte / Vitali Belobrovtsev

Index Scriptorium Estoniae

Belobrovtsev, Vitali, 1946-

2014-01-01

Vene näitlejast ja režissöörist Vassili Livanovist, kes kehastas Venemaa Kesktelevisiooni poolt 1980. a. valminud 11-osalises seriaalis Sherlock Holmesi. Ka seriaali episoodidest, mis filmitud Eestis

Jahindus = Hunting / Jüri Tõnisson, Kaarel Roht, Peep Männil

Index Scriptorium Estoniae

Tõnisson, Jüri, 1946-

2007-01-01

Jahimeeste poolt loendatavate ulukite arvukus ja küttimine. Statistilised andmed 1985-2005. aasta jahihooajast. Põdra arvukus ja küttimine 1960-2005. Erinevate jahiulukite populatsioonide seisund Eesti metsades. Tabelid, diagrammid, graafikud

Jahindus = Hunting / Jüri Tõnisson, Kaarel Roht, Peep Männil

Index Scriptorium Estoniae

Tõnisson, Jüri, 1946-

2008-01-01

Jahimeeste poolt loendatavate ulukite arvukus ja küttimine. Statistilised andmed 1985-2006. aasta jahihooajast. Põdra arvukus ja küttimine 1960-2006. Erinevate jahiulukite populatsioonide seisund Eesti metsades. Tabelid, diagrammid, graafikud

Sõjakurjategijate ja nende ohvrite kohtlemisest Eesti Vabariigis / Peep Varju

Index Scriptorium Estoniae

Varju, Peep

2009-01-01

Autor kritiseerib 1949. aasta märtsiküüditamises kannatanute võimalusi õigusabile ja küüditajate üle kohtumõistmise venimist. Viited okupatsioonirežiimide poolt represseeritud isiku seadusele

Natura 2000 ei sea elule ja majandusele asjatuid tõkkeid / Kadri Möller

Index Scriptorium Estoniae

Möller, Kadri

2004-01-01

Eesti Natura 2000 võrgustiku moodustamine on esimesse vahefinishisse jõudnud - aprilli lõpus saadeti Euroopa Komisjonile valitsuse poolt heaks kiidetud Eesti Natura 2000 linnu- ja loodusalade nimekiri koos andmebaasi ja kaardimaterjaliga

Menschenrechtliche Grenzen des polizeilichen Unterbindungsgewahrsams / Joachim Renzikowski, Reimund Schmidt-De Caluwe

Index Scriptorium Estoniae

Renzikowski, Joachim

2013-01-01

Politsei poolt vahi all pidamise inimõiguslikest piiridest. Vastavast kohtulahendist (Schwabe und M. G. gegen Deutschland), mis puudutab inimõiguste ja põhivabaduste kaitse konventsiooni art. 5 lk. 1 ja art. 11

Mõ za zonu stabilnosti na Baltike / Aleksandr Avdejev

Index Scriptorium Estoniae

Avdejev, Aleksandr

2000-01-01

Venemaa asevälisminister: Venemaa on huvitatud koostööst Baltimaadega ja stabiilsusest selles regioonis. Arvamused teemadel: Vene-Eesti suhted, integratsioonipoliitika, Läti sõjaveteranide marss, kaasmaalaste kaitse Venemaa valitsuse poolt

Kui kunst jäljendab elu : meetodi hullumeelne maailm / John Hiscock ; tõlk. Eda Post

Index Scriptorium Estoniae

Hiscock, John

2006-01-01

Lee Strasbergi poolt populariseeritud Stanislavskilik "meetodnäitlemine" filmides "Tramm nimega Iha", "The Hustler", "Withnail ja mina", "Bridget Jonesi päevik", "Carrie", "Raevunud härg", "Maratoonar", "Aviaator", "Hullusärk"

Simulation of MHD instability effects on burning plasma transport with ITB in tokamak and helical reactors

International Nuclear Information System (INIS)

Yamazaki, K.; Yamada, I.; Taniguchi, S.; Oishi, T.

2009-01-01

Full text: The high performance plasma behavior is required to realize economic and environmental-friendly fusion reactors compatible with conventional power plant systems. To improve plasma confinement, the formation of internal transport barrier (ITB) is anticipated, and its behavior is analyzed by the simulation code TOTAL (Toroidal Transport Linkage Analysis). This TOTAL code comprises a 2- or 3-dimensional equilibrium and 1-dimensional predictive transport code for both tokamak and helical systems. In the tokamak code TOTAL-T, the external current drive, bootstrap current, sawtooth oscillation, ballooning mode and neoclassical tearing mode (NTM) analyses are included. The steady-state burning plasma operation is achieved by the feedback control of pellet injection fuelling and external heating power control. The impurity dynamics of iron and tungsten is also included in this code. The NTM effects are evaluated using the modified Rutherford Model with the stabilization of the ECCD current drive. The excitation of m=2/n=1 NTM leads to the 20 % reduction in the central temperature in ITER-like reactors. Recently, the external non-resonant helical field application is analyzed and its stabilization properties are evaluated. The pellet injection effects on ITB formation is also clarified in tokamak and helical plasmas. Relationship between sawtooth oscillation and impurity ejection is recently simulated in comparison with experimental data. In this conference, we will show above-stated new results on MHD instability effects on burning plasma transport. (author)

Utility and diagnostic performance of Mycobacterium tuberculosis complex by two immunochromatographic assays as compared with the molecular Genotype assay in Nigeria

Directory of Open Access Journals (Sweden)

Benjamin Thumamo Pokam

2013-01-01

Full Text Available Among the disadvantages of smear microscopy for detection of tuberculosis cases is its inability to differentiate between Mycobacterium tuberculosis (MTB and non-tuberculous mycobacteria (NTM. This study evaluated two, new immunochromatographic assays – Capilia TB-Neo and SD Bioline – on unheated and heated cultures at 80 °C for 30 min respectively for their ability to discriminate between MTB complex and NTM as compared with the molecular Genotype assay. Mycobacteria used in the study were obtained from smear-positive specimens collected from patients at four major hospitals in Cross River State, Nigeria. Capilia TB-Neo and SD Bioline showed sensitivities of 98.8% and 93.8% respectively and 100% specificity for both assays. Heating the isolates did not significantly impact the test performance. Both tests are recommended for use in rapid differentiation of strains isolated in Nigeria.

Kui hea pressifoto on hea kunst = Good press photography as good art / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2012-01-01

Pressifoto ja kaasaegse kunsti seostest, pressifotost ja fotokunstist. Erik Prozese fotost "Minister, anna aru!" ja fotoseeriast "Eesti portreed taldrikutel", Andres Puttingu fotoseeriast "Suusakuninga tõehetk", Andres Haabu fotost "Lahing pooltühjas kinosaalis"

Apteekide finantsuuring / Olavi Grünvald

Index Scriptorium Estoniae

Grünvald, Olavi

2006-01-01

AS Pricewaterhouse Coopers Advisorsi poolt Eesti Apteekrite Liidu ja Eesti Apteekide Ühenduse tellimusel 2006. a. maist augustini tehtud uuringust apteekide finantsseisundi hindamiseks. Finantsnäitajate trendid aastatel 2000-2005. Lisatud statistilised tabelid

Dolce & Gabbana : irooniline glamuur / Antonio

Index Scriptorium Estoniae

Antonio

2002-01-01

1982. a. Milaanos rätsep Domenico Dolce ja graafilise disaineri Stefano Gabbana poolt asutatud firma Dolce & Gabbana ajaloost, stiilist, kaubamärkidest. Gerli Tinni ja Elektra kommentaarid (vt. http://www.dolcegabbana.it/)

Sussides mees tõi auhinna Eestisse / Tarmo Michelson

Index Scriptorium Estoniae

Michelson, Tarmo, 1975-

2001-01-01

Eesti reklaamibüroo Teamart Promotion idee põhjal Tuisk Film Productioni poolt toodetud Eesti Loto reklaamiklipp "Sünd" võitis ülemaailmsel lotoorganisatsioonide konverentsil New Mexico osariigis Albuquerques reklaamfilmide imago-kategoorias peapreemia

Äriühingu juhatuse liikme teenistusalane suhe : [bakalaureusetöö] / Anneli Kiljako ; Tartu Ülikool, õigusteaduskond ; juhendaja: Inge-Maret Orgo

Index Scriptorium Estoniae

Kiljako, Anneli

1999-01-01

Äriühingu juhatuse liikme teenistusalase suhtega seonduvad probleemid, äriühingu juhatuse liikme ja ja äriühingu vahelise lepingu sõlmimine, poolte õigused, kohustused, vastutus; juhtimislepingu lõppemine

A separate state within the capital / Riho Rasmann ; interv. Urmas Vahe

Index Scriptorium Estoniae

Rasmann, Riho

2003-01-01

Tallinna sadama tähtsusest Eesti riigi ja Tallinna jaoks, sadama poolt pakutavatest teenustest, EL-iga ühinemise mõjust Tallinna Sadama ning Eesti transiitkaubanduse arengule. Diagramm: Toodangumahud Läänemere idapoolsetes sadamates

Väärtpaberite pantimise õiguslikud aspektid : [bakalaureusetöö] / Ardo-Heiki Ingar ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

Index Scriptorium Estoniae

Ingar, Ardo-Heiki

2006-01-01

Väärtpaberitagatistest Eesti õiguskorras, tagamistehingud ja tagatised, väärtpaberitehingute tagamine pandiga, Euroopa Parlamendi ja nõukogu finantstagatiskokkulepete direktiivi rakendamine Eesti õiguskorras, Eesti väärtpaberitagatiste regulatsiooni vastavus EBRD poolt

Vopros võzhivanija : intervju s Gotshem / Vassili Gotsh ; interv. Roza Videlgauz

Index Scriptorium Estoniae

Gotsh, Vassili

2001-01-01

Vestlus rahvusvaheliselt tuntud akadeemiku, filosoofia ja tehnika teaduste doktori Vassili Gotsh'iga tema poolt väljatöötatud põhjuslikkuse teooriast ja sellel baseeruvast ravimetoodikast, 5. jannuaril 1992 alanud Uuest Ajastust

Hiiglasliku uinunud Buddha kuju otsing jätkub täie hooga / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

Afganistani arheoloog Zemarzyali Tarzi leidis 19-meetrise lamava Buddha kuju. Arheoloog tahab taastada Talibani poolt hävitatud 38 ja 55 meetrit kõrged Buddha kujud, mis olid püstitatud 6. sajandil

Baltic PMs urge support for EU

Index Scriptorium Estoniae

2003-01-01

Eesti peaministri Juhan Partsi, Läti peaministri Einars Repshe ja Leedu peaministri Algirdas Brazauskase ühisavaldusest Eestile ning Lätile järgimaks Leedu eeskuju referendumil EL-i poolt hääletamises

Limits of free speech to be tested / Matt Kovalick

Index Scriptorium Estoniae

Kovalick, Matt

2003-01-01

Euroopa Inimõiguste Kohtu arupärimisest Leedu justiitsministeeriumile seoses sõnavabaduse väidetava rikkumisega Danute Balsyte-Lideikiene poolt välja antud 2000. aasta Leedu kalendri konfiskeerimisel, mis levitas natsionalistlikke ideid

Ameerika Ühendriike veel ei ähvarda rahvastiku vananemine : vanadus / Nikolai Botev ; interv. R[eet] V[arblane

Index Scriptorium Estoniae

Botev, Nikolai

2005-01-01

Nikolai Botevi juhitud ÜRO uurimisgrupi poolt läbi viidud maailma rahvastiku vanuselise koosseisu uurimusest. N. Botev esines projekti "Homo grandis natu" raames toimunud seminaril "Eesti vananemispoliitika täna ja homme"

Dekooridiiva Tricia Guild / Piret Veigel

Index Scriptorium Estoniae

Veigel, Piret, 1961-

2004-01-01

Briti tekstiilikunstniku Tricia Guildi viimasest kollektsioonist, kus vastanduvad suureõielised ja triibulised mustrid, tema poolt avaldatud raamatuid. Tricia Guild juhib sisustuskangaid, tapeete ja mööblit tootvat firmat Designer's Guild. 5 ill

Rakvere Teater mängib Kino-Mati lugu / Toomas Suuman

Index Scriptorium Estoniae

Suuman, Toomas

2002-01-01

Näitleja Erik Ruus Toomas Raudami poolt kirjapandud kinomehaanik Mati Parkja töödest-tegemistest jutustavas näidendis "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid", lavastaja Peeter Simm

Центр русской культуры: юбиляр с богатой историей / Йосеф Кац

Index Scriptorium Estoniae

Кац, Йосеф, 1977-

2014-01-01

Praeguse Mere puiestee hoonestusest alates 1857. aastast. Seal kandis tegutsenud Vassili Simeonovitš Voinovi poolt rajatud kinodest Ars ja Grand Marina. Tallinna Laevastiku Ohvitseride Maja, praeguse Vene Kultuurikeskuse hoone (Mere pst 5) ehitusest

GDA sinu abimees pakendil / Piret Jaaks ; kommenteerinud Elena Burm

Index Scriptorium Estoniae

Jaaks, Piret, 1980-

2010-01-01

Euroopa Komisjoni kokku kutsutud toitumisteadlaste komisjoni Eurodiet poolt koostatud GDA toitumisjuhist toiduainepakenditel, mis aitab jälgida toote- või joogiportsjoni osatähtsust päevasest soovitatavast kalorite ning olulisemate toitainete kogusest

10 stiilset reisiseiklust aastaks 2010

Index Scriptorium Estoniae

2010-01-01

Briti reisiraamatute autorite ja kirjastajate, loodusgiidide ja -fotograafide poolt reastatud 10 kõige unikaalsemat ja erutavamat reisikogemust ja -seiklust aastaks 2010 ja 5 paika, mille vaatamisväärsused on hävimisohus

Hamburgeridieet : ühe kuuga 11 kilo juurde / Kaire Kenk

Index Scriptorium Estoniae

Kenk, Kaire, 1964-

2005-01-01

Noor ameerika režissöör toitus kuu aega ainult McDonald'si kiirtoidust ning väntas eksperimendist dokumentaalfilmi "Ülisuur mina" ("Super Size Me"). Kiirtoidu poolt põhjustatud tervisekahjustustest

Priglashenije napast / Nargiz Assadova

Index Scriptorium Estoniae

Assadova, Nargiz

2005-01-01

USA ja Iraani halvenenud suhete ajaloost. USA poolt Afganistanis ja Iraagis peetav sõda võimaldas Iraanil vabaneda oma vaenlastest Saddam Husseinist ja Talibani võitlejaist. Iraani mõjuvõimu kasv regioonis, tuumaprogramm

Hiilgav, aga... vol.2 / Alar Niineväli

Index Scriptorium Estoniae

Niineväli, Alar

2008-01-01

Ameerika telesarjad, mis on heatasemelised, kuid tootjate poolt liiga vara ära lõpetatud, enamasti kasumlikkusest lähtudes : "Action" (1999), "Now and Again" (1999), "Firefly" (2002), "Freaks and Geeks" (1999), "Undeclared" (2001)

Uus eestikeelne logistikatarkvara

Index Scriptorium Estoniae

2003-01-01

OÜ MS Micro poolt välja töötatud Logisticar paketist, mis koosneb tarkvarast ja koolitusest, ning võimaldab optimeerida laokulusid ning materjalihankeid. Skeem: Uus logistikatarkvara ühendab firma eri tegevused

Yoga tõuseb tuhast: hoidke alt India, USA ja Araabia Ühendemiraadid ! / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2010-01-01

2008. a. pankrotistunud tarkvarafirma Yoga IB kavatseb taas naasta infotehnoloogia turule. Firma poolt väljatöötatud tarkvaralahenduste abil on võimalik ruumides kontrollida kliimatingimusi, valgustust, liikumist ja turvasüsteeme

Guns and lenses / Urmas Vahe

Index Scriptorium Estoniae

Vahe, Urmas

2003-01-01

Eesti metsades jahitavatest loomadest ja lindudest, siinsetest jahindustraditsioonidest, Riigimetsa Majandamise Keskuse poolt pakutavatest jahinduspakettidest ning RMK ja Eesti Loodusmuuseumi koostöös korraldatud fotokonkursist. Vt. samas: Come to the forest! State forest!

Muusajüngrid pühitsesid Kreutzwaldi 200. sünnipäeva / Toomas Pill

Index Scriptorium Estoniae

Pill, Toomas

2004-01-01

13. dets. 2003 Sydneys toimunud tähtpäevaüritusel esines Toomas Pill referaadiga "Kalevipoja" retseptsioonist, loeti ette katkendeid Kreutzwaldi ja Koidula kirjavahetusest ning deklameeriti Heidi Aedma poolt valitud katkendeid "Kalevipojast"

31. X avati Eesti Kunstimuuseumi Niguliste filiaalis muuseumi uus eksponaat...

Index Scriptorium Estoniae

2002-01-01

Avati Franz Hoppenstätti poolt Niguliste kiriku patrooni, Ingerimaa asehaldur Bogislaus von Roseni hauakabelile 1655. a. nikerdatud puidust ehissein, mille konserveeris restauraator Hedi Kard. Seina kirjeldus. 1. XI pühakuteteemaline ekskursioon

Kadunud vili ja Eesti haldussuutlikkus / Kaul Nurm

Index Scriptorium Estoniae

Nurm, Kaul

2004-01-01

Teravilja julgeolekuvaru kadumise tagajärjed ja õppetunnid Euroopa Liidu poolt vaadatuna. Autori arvates oleks olnud vili alles, kui põllumajandusminister Tiit Tammsaar oleks kasutanud oma aega enda valitsemisalas riigi haldussuutlikkuse tõstmisele

"Demokratiseerimine" Guatemala moodi / Tõnu Prei

Index Scriptorium Estoniae

Prei, Tõnu, 1950-

2004-01-01

Guatemala ajaloost, Ameerika Ühendriikide poolt Guatemalas toime pandud riigipööretest ja kodusõjas toimunud maia-indiaanlaste genotsiidist, mille eest vastutavaid isikuid on nüüd hakatud kohtu alla andma

International Symposium in Norway : Occupational health in small and medium-sized enterprises / Hubert Kahn

Index Scriptorium Estoniae

Kahn, Hubert, 1930-

1998-01-01

28.-30. mail 1998. a. Rahvusvahelise Tööinspektsiooni Assotsiatsiooni (IALI) ja Norra Tööinspektsiooni poolt Bergenis korraldatud tööohutuse ja töötervishoiu alasest rahvusvahelisest sümpoosiumist

Hagi tagamine ja esialgne õiguskaitse tsiviilasjades: rahvusvaheline mõõde / Gea Lepik, Maarja Torga

Index Scriptorium Estoniae

Lepik, Gea, 1989-

2013-01-01

Kaitsemeetmete kohaldamine Eesti kohtute poolt välisriigis asuva vara või isikute suhtes. Kaitsemeetmed seoses välisriigis toimuva kohtumenetlusega. Välisriigi kohtute kohaldatud kaitsemeetmete Eestis tunnustamine ja täidetavaks tunnistamine

The Past is Present / Mika Hannula

Index Scriptorium Estoniae

Hannula, Mika

1998-01-01

Ajaloosündmuste interpreteerimisest kaasaegsete poolt, selle subjektiivsusest. Vaidlus Holocausti memoriaali üle Berliinis, Moskva 850. aastapäeva tähistamine, 'Estonia' hukule pühendatud monumendi püstitamine Stockholmi jm

Geroi komiksa : so stranits - na ekranõ / Oleg Nikolajev

Index Scriptorium Estoniae

Nikolajev, Oleg

2000-01-01

Koomiksite jõudmisest kinoekraanidele. Mängufilm "X-mehed" ("X-Men") oli esimene kirjastuse Marvel Comics poolt väljaantud koomiksi põhjal tehtud film. Kavas on Hollywoodil neid praegu vähemalt 12

Eraõigusliku juriidilise isiku organi liikmete õigussuhted / Kalev Saare

Index Scriptorium Estoniae

Saare, Kalev, 1974-

2010-01-01

Eraõiguslike juriidiliste isikute organi mõistest aktsiaseltsi ja osaühingu näitel, organiliikmete sisesuhte tekkimisest ja tsiviilseadustiku üldosa seaduse poolt määratud sisesuhte sisusse kuuluvatest peamistest kohustustest

Kaugelt kumisev tuttav Tormise laul / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2008-01-01

Aprilli lõpus briti sõltumatu plaadifirma Hyperion poolt välja antud Veljo Tormise lauludega heliplaadist "Tormis: Coral Works", millel Holst Singersi kammerkoori juhatab Stephen Layton. Heliplaadi The Times'is ilmunud arvustusest

Ramon Rask võitleb põhimõtte pärast / Marian Männi

Index Scriptorium Estoniae

Männi, Marian

2007-01-01

Portreelugu Tartu Ülikooli õigusteaduskonna cum laude lõpetanud Ramon Raskist, tema kohtuvõitlusest ülikooliga; professionaalse tasuta õigusabi võimalustest tudengitele Paul Varuli advokaadibüroo poolt Eesti Üliõpilasliidu juures

Tervishoiutöötajate vajaduse ja arvu prognoos laienenud Euroopa kontekstis / Epp Kallaste, Andres Võrk

Index Scriptorium Estoniae

Kallaste, Epp

2004-01-01

Artikkel põhineb Poliitikauuringute Keskuse PRAXIS poolt sotsiaalministeeriumi tellimusel tehtud uurimusel "Tervishoiutöötajate migratsioon Eestist: migratsiooni potentsiaalne suurus, mõju tervishoiutöötajate vajadusele ja poliitikavalikud". Skeem. Tabel. Diagrammid. Graafikud

Eestlased juhivad Juulikult katseid eurooplaste toiduga / Agne Narusk

Index Scriptorium Estoniae

Narusk, Agne, 1971-

2010-01-01

Eesti Maaviljeluse Instituudi poolt juhitavast rahvusvahelisest projektist Flavoure (Food and Feed Laboratory of Varied and Outstanding Research in Estonia). Projekti eesmärgiks on toidu- ja söödakvaliteediga seotud riskide hindamine

Eesti kohtute esimesed eelotsusetaotlused said lahenduse : Euroopa Kohtu 4. juuni 2009. a otsused asjades C-241/07 (JK Otsa Talu) ja C-560/07 (Balbiino) / Uno Lõhmus

Index Scriptorium Estoniae

Lõhmus, Uno, 1952-

2009-01-01

Euroopa Kohtus said vastuse kaks esimest Eesti kohtute poolt esitatud eelotsusetaotlust: C-241/07 keskkonnasõbraliku põllumajandustootmise toetamise kohta ja C-560/07 üleliigse laovaru tasu määramise kohta

Viru poeg läheb sõtta / Yrjö Vanhanen, Risto Vahimets ; interv. Heidit Kaio

Index Scriptorium Estoniae

Vanhanen, Yrjö

2006-01-01

Intervjuu Viru poega arendava firma Pontos juhi Yrjö Vanhaneniga ja juristi Risto Vahimetsaga Viru hotelli juurdeehituse peatamisest Tallinna linnavalitsuse poolt. Kommenteerib Igor Volkov. Vt. samas: Tallinlased, seadke end valmis - Viru Poeg tuleb!

"Belõje slonõ" gotovõ k razdatshe / Viktor Matizen

Index Scriptorium Estoniae

Matizen, Viktor

2006-01-01

Venemaa filmikriitikute auhinna "Zolotoi Oven" asemel jagatakse sel aastal esmakordselt Ivan Maksimovi poolt modelleeritud "Valgeid Elevante" ("Belõi slon"). Vene filmikriitikute gildi president selle aasta nominentidest. Lisa : nimekiri "Nominandid preemiale "Valge Elevant" -2005"

Ostsillaatori stabiilsus stohhastilise resonantsi korral = Stability of an oscillator in the case of stochastic resonance : I koht magistritööde kategoorias / Katrin Laas

Index Scriptorium Estoniae

Laas, Katrin

2009-01-01

Töö eesmärgiks on leida, kuidas sõltub harmoonilise jõu poolt võnkuma pandud ostsillaatoris ilmnev stohhastiline resonants keskkonna mittetasakaaluliste fluktuatsioonide parameetritest ning analüüsida stohhastilise ostsillaatori stabiilsust

Mälupulga kaotaja sai karistada / Tarmo Vahter

Index Scriptorium Estoniae

Vahter, Tarmo, 1970-

2007-01-01

Tarkvarafirma Mindworks Industries töötaja kaotas mälupulga, millel olid 302 067 kaitseväekohuslase isikuandmed. Firma osaniku ja tegevjuhi Kaspar-Patrik Loidi ülekuulamisest andmekaitse inspektsiooni vaneminspektori Veigo Rivise poolt

Takistusteta kõrgkooliõpe?! / Getter Tiirik

Index Scriptorium Estoniae

Tiirik, Getter

2010-01-01

SA Archimedes PRIMUS programmi töörühma poolt välja töötatud juhendmaterjalist kõrgkoolidele ”Takistusteta kõrgkooliõpe”, et tagada erivajadustega tudengitele tugiteenused kõrghariduse omandamisel

Energy leads talks

Index Scriptorium Estoniae

2011-01-01

Leedu energeetikaminister Arvidas Sekmokas lubab teha kõik endast sõltuva, et Leedus hakataks põlevkivigaasi tootma. Baltimaade peaministrid ei ole suutnud siiani otsustada, millisesse riiki tuleb EL-i poolt osaliselt finantseeritav LNG-terminal

Procedural primacy and effective judicial protection: A trilogue / Dominik Düsterhaus

Index Scriptorium Estoniae

Düsterhaus, Dominik

2016-01-01

Menetluse ülimuslikkusest ja efektiivsest kohtulikust kaitsest. Määrusest nr. 44/2001, kohtu poolt määratud esindajast, siseriikliku õiguse ühilduvusest hartaga. Kohtulahendi nr: C-112/13 analüüs

Vaja on professionaalseid oskusi! / Tiina Lokk ; interv. Maria Ulfsak

Index Scriptorium Estoniae

Lokk, Tiina, 1955-

2004-01-01

Eesti poolt Leedu teleprogrammide ja -filmide festivalil "Amber arch" žüriis osalenud T. Lokk nähtud filmidest ja peapreemia võitnud Priit Valkna dokumentaalfilmist "Hunt", mille tootis Allfilm ETV "Eesti lugude" dokumentaalsarja

Vändra aabitsameistrid / Lembit Andresen

Index Scriptorium Estoniae

Andresen, Lembit, 1929-2016

2009-01-01

1880-ndate aastate alguses tõusis aabitsatootjate keskusena esile Vändra, kuhu oli kogunenud silmapaistvate võimetega koolimehi. Sealsete koolmeistrite Johannes Lüdimoisi, Jaan Kruusi ja Mats Tõnissoni poolt välja antud aabitsatest

4. aprill 2014 Elleri Muusikakool. Tubina päev

Index Scriptorium Estoniae

2014-01-01

Rahvusvahelise Eduard Tubina Ühingu poolt Tartu Muusikakoolis korraldatud konverentsist, kontserdist ja E. Tubina "Kogutud teoste" III köite esitlusest, millega tähistatakse helilooja kõigi sümfooniate 1-10 ilmumist

Vike-Freiberga calls on Russia to re-evaluate its history / Aaron Eglitis

Index Scriptorium Estoniae

Eglitis, Aaron

2003-01-01

Rahvusvahelisel holokausti uurimise konverentsil avaldas Läti president Vaira Vike-Freiberga kahetsust, et kuna Venemaa ei soovi tunnistada Läti okupeerimist Nõukogude Liidu poolt 1940. aasta juunis, tekitab see probleeme Läti-Vene suhetes

Projekti Min-E-Max kohtumine Saksamaal / Katrin Arge

Index Scriptorium Estoniae

Arge, Katrin

2005-01-01

Oktoobri keskel toimus Lõuna-Saksamaa väikelinnas Oberderdingenis Hispaania, Portugali, Ungari, Leedu, Eesti ja Saksamaa õpetajate kohtumine seoses Euroopa Liidu poolt rahastatava Comenius1 projektiga Min-E-Max (minimum energy input maximum output)

Kuidas püüda hetke / Taimi Elenurm

Index Scriptorium Estoniae

Elenurm, Taimi

2009-01-01

Olevikule keskendumise positiivsest mõjust eluga edasi liikumisel ning vabanemaks kammitsevatest hinnangutest, samuti inglise psühholoogide Gill Hassoni ja Helena Pozniaki poolt kirjeldatud kuuest sammust, mis aitavad leida kontakti olevikuga ning olla õnnelikud

Latvia extends final "yes" to EU / Roxanne Khamsi

Index Scriptorium Estoniae

Khamsi, Roxanne

2003-01-01

Lätlased hääletasid Euroopa Liiduga liitumise poolt. Kommentaarid Läti peaministrilt Einars Repshelt, Läti Iseseisvuspartei ja "Ei Euroopa Liidule" juhilt Normunds Krostinsilt ja Läti presidendi majandusnõunikult Sol Bukingoltsilt

Edgar Savisaar : peaminister 08.05.1990-29.01.1992 / Edgar Savisaar ; interv. Jaak K. Roosaare

Index Scriptorium Estoniae

Savisaar, Edgar, 1950-

2007-01-01

Akadeemias Nord erikursuse raames esinenud ekspeaminister Edgar Savisaare poolt käsitletud põhiteemad: peaministriks saamise asjaolud, probleemid peaministriks olemise ajal, õnnestumised ja ebaõnnestumised, hinnang tolleaegsele valitsusele ja pressile, hinnang riigi senisele arengule

Muutuv kommunikatsioon kultuuri ei ohusta / Annika Poldre

Index Scriptorium Estoniae

Poldre, Annika

2011-01-01

Tallinna Konverentside poolt Sokos Hotel Virus 28. aprillil 2011 korraldatud kommunikatsiooni aastakonverentsist "Muutuv kommunikatsioon: vana ei taha ja uut ei oska. Kuidas edasi?", kus esinesid Ahto Lobjakas, Priit Põiklik, Piia Tamm ja Marju Lauristin

Enesekaitsesituatsioonides vahetu sunni kasutamine vanglas. Karistusõiguslik ja haldusõiguslik analüüs / Anneli Soo, Kaidi Tarros

Index Scriptorium Estoniae

Soo, Anneli, 1984-

2015-01-01

Vanglaametniku poolt vahetu sunni kasutamisest enese või teise isiku kaitseks. Vahetu sunni kasutamise nõuetest vangistusõiguses, vanglaamentiku vastutuse välistamise tingimustest karistusseadustiku (KarS) alusel ning distsiplinaarvastutusest ja riigivastutusest. Asjakohasest kohtupraktikast

Valimistulemusi pole, süüdistus on / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2010-01-01

Iraagi parlamendivalimiste esialgsetest tulemustest. Endine peaminister Iyad Allawi süüdistab praeguse peaministri Nuri al-Maliki blokki valimispettuste korraldamises. Mitmeid tema poolt välja toodud rikkumisi on ka diplomaadid ja valimisvaatlejad kinnitanud

Nuclear project back on track / Matt Garrick

Index Scriptorium Estoniae

Garrick, Matt

2011-01-01

1. juuniks on Leedu valitsus saanud Visaginasesse rajatava tuumaelektrijaama puudutavad investeerimisettepanekud Hitachi-GE Nuclear Energy Limited, General Electric Co. ja Westlinghouse Electric Company poolt. Peaminister Andrius Kubiliuse sõnul toob tuumaelektrijaam Leetu energiasõltumatuse

Mida arutati Brüsselis / Ülo Kalm

Index Scriptorium Estoniae

Kalm, Ülo, 1935-

2004-01-01

EL Põllumajandusorganisatsioonide Komitee (COPA), Põllumajanduskoostöö Keskkomitee (COGECA) ja Euroopa Komisjoni piimandusalase töögrupi istungitel 2003. aasta lõpul arutlusel olnud teemadest Eesti esindajate poolt EPKK-le esitatud info põhjal

Riina Vändre is the best P.R. manager in Estonia / Riina Vändre

Index Scriptorium Estoniae

Vändre, Riina, 1972-

2004-01-01

Turu-uuringute AS-i poolt ajakirjanike hulgas läbi viidud küsitluse tulemusel Eesti parimaks suhtekorraldajaks valitud Eesti Energia avalike suhete juht oma tööst monopoolse suurettevõtte maine kujundamisel

Euroopa Merepäev / J. Parts, T. Kõuts, A. Mäkinen ... [jt.

Index Scriptorium Estoniae

2009-01-01

Kokkuvõte Majandus- ja kommunikatsiooniministeeriumi, EVA, Eesti Meremuuseumi ja Eesti Laevaomanike Liidu poolt 20.05.2009 Euroopa Merepäeva tähistamiseks korraldatud seminari, mille moderaator oli Eero Pärgmäe, ettekannetest.

Eesti Telekomile prognoositakse teiseks kvartaliks kahjumit / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2004-01-01

Eesti Ühispanga ja Suprema Securities analüütikute hinnangul võivad 2004. aasta II kvartalis Eesti Telekomi poolt makstud suured dividendid tuua kaasa firma langemisse kahjumisse 27-34 miljoni krooni ulatuses. Diagramm

Juhid langevad puuduliku täideviimise tõttu

Index Scriptorium Estoniae

2004-01-01

Nõustamisfirmade Franklin Covey ja McKinsey & Co poolt aastatel 1986-1996 läbiviidud uuringu "Evergreen Project" käigus tehti kindlaks, millistel protsessidel ja juhtimisvahenditel on põhjuslik mõju ettevõtete edukusele

European identity and support for European integration: a matter of perceived economic benefits? / Soetkin Verhaegen, Marc Hooghe, Ellen Quintelier

Index Scriptorium Estoniae

Verhaegen, Soetkin

2014-01-01

Artiklis käsitletakse seoseid ühelt poolt majandusliku kasu ja teisalt Euroopa integratsioonile antava toetuse ja Euroopa identiteedi vahel, aluseks majandusliku utilitarismi seisukohad. Empiirilne materjal pärineb Eurobaromeetri 2011. aasta maikuu uuringust.

Secret agent's death is under re-investigation / Rokas M. Tracevskis

Index Scriptorium Estoniae

Tracevskis, Rokas M.

2010-01-01

Leedus hakatakse taas uurima kahtlastel asjaoludel Valgevenes hukkunud julgeolekuteenistuse ohvitseri Vytautas Pociunase surma, mis võib olla seotud Ameerika Ühendriikide poolt Valgevene opositsioonile eraldatud toetussummade kadumise uurimisega. EL-i saadiku Leonidas Donskise arvamus

Gianni Versace'i villa müügis

Index Scriptorium Estoniae

1999-01-01

Miami Beachil asuv Gianni Versace'i luksusvilla, mille ees moekunstnik 1997. a. tapeti, pandi Versace'i perekonna poolt müüki hinnaga 23 miljonit dollarit. Kommenteerib G. Versace'i õde moekunstnik Donatella Versace

Vilnitis behind crackdown on CPB staff

Index Scriptorium Estoniae

2010-01-01

Korruptsiooniga võitlemise büroo esimees Normunds Vilnitis nõudis pärast sama asutuse aseesimehe Alvis Vilksi poolt uudisteagentuurile LETA antud intervjuud viimase kabineti läbiotsimist, et tema kabinetist diktofoni leida

Russia coordinates new broadside against OSCE / Liz Fuller

Index Scriptorium Estoniae

Fuller, Liz

2004-01-01

SRÜ maade poolt 8. juulil 2004 Viinis tehtud avaldusest, mille kohaselt sekkub Euroopa Julgeoleku- ja Koostööorganisatsioon (OSCE) riikide siseasjadesse ning rakendab topeltstandardeid. Avaldusega ei ühinenud Gruusia ja Aserbaidžaan

Ülikooli digitõuge / Terje Väljataga

Index Scriptorium Estoniae

Väljataga, Terje

2015-01-01

Tallinna Ülikooli haridustehnoloogia keskuse meeskonna poolt koostöös tehnoloogiaettevõttega Samsung läbi viidavatest digipöörde alastest nõustamis- ja koolitusprogrammidest õppetöös nutiseadmeid rakendavatele koolidele

Bolshoi vopross : Dolzhnõ li mõ bojatsja kontrolja Kremlja nad energetitsheskim snabzhenijem Jevropõ?

Index Scriptorium Estoniae

2006-01-01

Venemaa valitsuse poolt kontrollitav Gazprom kuulub maailma suurimate maagaasi tootjate hulka ning rahuldab 20 protsenti maailma nõudlusest, kontserni tähtsusest Lääneriikide ja Venemaa jaoks. Gazpromi huvist Suurbritannia firma Centrica vastu

F. J. Wiedemanni keeleauhind on lakanud. Elagu F. J. Wiedemanni keeleauhind! / Eevi Ross

Index Scriptorium Estoniae

Ross, Eevi

2003-01-01

15-ndad ja viimased F. J. Wiedemanni Keeleauhinna Sihtasutuse laureaadid on Mati Hint ja Helju Vals, järgmisel aastal antakse välja esimene riiklik F. J. Wiedemanni keeleauhind Eesti Vabariigi peaministri poolt

Nastojashtshih hristjan nelzja prinudit / Aleksandr Men

Index Scriptorium Estoniae

Men, Aleksandr

2001-01-01

Osa Aleksander Men'i poolt ettevalmistatud Piibli-teemalisest sõnastikust : m ja n täht : vabamüürlus ja Piibel, Dmitri Merezkovski, Methodios, mormoonide Piibli-tõlgendus, Nikolai Morozov, mittekristlikud tunnistused Kristusest

Järjekordse ravimiseaduse eelnõu saatusest / Kaidi Vendla

Index Scriptorium Estoniae

Vendla, Kaidi

2007-01-01

Eelnõu kooskõlastusring Rahandus-, Majandus- ja Kommunikatsiooni- ja Justiitsministeeriumi vahel. Rahandusministri Aivar Sõerdi, majandusministri Edgar Savisaare ja justiitsministri Rein Langi põhjendustest, miks nad Sotsiaalministeeriumi poolt esitatud ravimiseaduse muutmise seadust ei kooskõlastanud

Põhimaksejõuetusmenetluse algatamise probleeme / Annemari Õunpuu

Index Scriptorium Estoniae

Õunpuu, Annemari, 1983-

2005-01-01

Euroopa Nõukogu poolt 29. mail 2000 vastu võetud ja 31. mail 2002 jõustunud maksejõuetusmenetluse määruse nr 1346/2000 järgi juriidiliste isikute esmase pankrotimenetluse algatamisega seotud probleemidest

Traspordiühenduse mõjust saarte majanduskeskkonnale / Enno Lend

Index Scriptorium Estoniae

Lend, Enno

2006-01-01

Autori hinnangul on saarte majanduskeskkonna arengus kaks vastandlikku eesmärki: saartele omase majanduskeskkonna ja miljööväärtuse säilitamine ning teiselt poolt sulandumine ja saartele omaste erisuste kadumine

Nia - rõõm liikumisest / Monica Raud ; kommenteerinud Sirje Sinisoo

Index Scriptorium Estoniae

Raud, Monica, 1981-

2014-01-01

1983. aastal Debbie ja Carlos Rosaśide poolt üheksast liikumistehnikast - taekwondo, aikido, taiji, dšässtants, moderntants, Isadora Duncani tants, Feldenkraisi meetod, Aleksanderi tehnika ja jooga - sünteeritud liikumisõpetusest

Istorija odnogo posvjashtshenija / Pavel Reifman

Index Scriptorium Estoniae

Reifman, Pavel, 1923-2012

1998-01-01

Bibl. märkustes, lk. 50. Kokkuvõte inglise k. lk. 280. Zara Mintsi ja Juri Lotmani suhetest tšehhi kirjandusteadlastega ja nende seisukohast Tšehhoslovakkia okupeerimisse Varssavi pakti riikide poolt 1968. a

Maria Minerva - Eesti esimene hüpnagoogilise popi staar / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2011-01-01

Maria Minerva nime all tegutsevast Londonis õppivast muusikust Maria Juurest. Muusiku USA-s plaadifirma Not Not Fun poolt välja antud helikassetist Maria Minerva "Tallinn At Down" ja heliplaadist Maria Minerva "Noble Savage"

Clinical manifestations, diagnosis, and treatment of Mycobacterium haemophilum infections.

NARCIS (Netherlands)

Lindeboom, J.A.; Bruijnesteijn van Coppenraet, L.E.; Soolingen, D. van; Prins, J.M.; Kuijper, E.J.

2011-01-01

Mycobacterium haemophilum is a slowly growing acid-fast bacillus (AFB) belonging to the group of nontuberculous mycobacteria (NTM) frequently found in environmental habitats, which can colonize and occasionally infect humans and animals. Several findings suggest that water reservoirs are a likely

Clinical manifestations, diagnosis, and treatment of Mycobacterium haemophilum infections

NARCIS (Netherlands)

Lindeboom, J.A.; Bruijnesteijn van Coppenraet, L.E.S.; van Soolingen, D.; Prins, J.M.; Kuijper, E.J.

2011-01-01

Mycobacterium haemophilum is a slowly growing acid-fast bacillus (AFB) belonging to the group of nontuberculous mycobacteria (NTM) frequently found in environmental habitats, which can colonize and occasionally infect humans and animals. Several findings suggest that water reservoirs are a likely

2

African Journals Online (AJOL)

A questionnaire was used to obtain demographic data. ... but shows mycolic acid patterns closely related to that of M. xenopi, is also being reported to cause ... The other NTM species which have been associated with lung disease in HIV/AIDS ...

Nontuberculous mycobacteria in non-AIDS patients

Directory of Open Access Journals (Sweden)

A. Marinho

2008-05-01

Full Text Available Nontuberculous mycobacteria (NTM play an increasingly significant pathogenic role in HIV-positive patients, in patients with chronic lung disease, in other chronic conditions and in the elderly. Aims: Evaluate the importance of NTM isolation in respiratory samples in patients without HIV-infection. Methods: Retrospective evaluation of our hospital patients with no known AIDS, with at least one NTM positive respiratory sample, from 1997-2004. Results: We found 102 patients, with a median age of 63 years; 67% male. Sixty-three (62% had underlying lung disease, mainly tuberculosis sequelae (n = 19. The majority (47% of the isolations were Mycobacterium avium complex (MAC.A diagnosis of Mycobacterium pulmonary disease was made in 16 patients (15.7%, 14 of which met the American Thoracic Society diagnostic criteria. Ten male and 6 female; median age 65 years. Twelve had underlying lung disease. All of them had respiratory infection complaints. Chest X-rays showed mainly pulmonary infiltrates, linear opacities and cavitation. MAC was the cause of mycobacterium respiratory disease in 12 patients (75%. Conclusion: NTM isolation did not equal pulmonary NTM disease in the majority of cases, even in patients with underlying lung disease. MAC was the most commonly isolated agent and its relative importance was higher in the presence of NTM disease. Resumo: As micobactérias não tuberculosas (MNT têm um papel patogénico de importância crescente em doentes com serologia positiva para o vírus da imunodeficiência humana (VIH, em doentes com doença pulmonar crónica, em outras doencas crónicas, e ainda nos idosos. Objectivo: Avaliar a importância do isolamento de MNT em amostras respiratórias em doentes adultos sem infecção VIH. Material e métodos: Estudo retrospectivo dos doentes do Hospital de São João sem infecção VIH conhecida, com pelo menos uma amostra respiratória positiva para MNT, entre 1997 e 2004. Resultados: Foram encontrados 102

Kahest halvast variandist parem / Ravil Khair Al-Din

Index Scriptorium Estoniae

Al-Din, Ravil Khair

2007-01-01

USA presidendi George W. Bushi uuest Iraagi-strateegiast ja selle kriitikast USA demokraatide poolt. Autor on seisukohal, et kui USA tahab vastutada oma seniste tegude eest Iraagis, siis saab ta seda teha vaid Iraagist lahkumata

Milline on hea maksusüsteem? Mirrlees Review vastab / Risto Kaarna

Index Scriptorium Estoniae

Kaarna, Risto, 1985-

2010-01-01

Ülevaade maailma tunnustatud maksuteoreetikute poolt koostatud ülevaatest "Tax by design" (Mirrlees Review). Ülevaade pakub välja üldise hea maksusüsteemi. Uurimuse juhiks on Nobeli preemia laureaat Sir James Mirrlees