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Sample records for mild hybrids presentation

  1. Fuel Economy and Performance of Mild Hybrids with Ultracapacitors: Simulations and Vehicle Test Results (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Gonder, J.; Pesaran, A.; Lustbader, J.; Tataria, H.

    2009-06-01

    NREL worked with GM and demonstrated equivalent performance in the Saturn Vue Belt Alternator Starter (BAS) hybrid vehicle whether running with its stock batteries or a retrofit ultracapacitor system.

  2. Battery Test Manual For 48 Volt Mild Hybrid Electric Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Lee Kenneth [Idaho National Laboratory

    2017-03-01

    This manual details the U.S. Advanced Battery Consortium and U.S. Department of Energy Vehicle Technologies Program goals, test methods, and analysis techniques for a 48 Volt Mild Hybrid Electric Vehicle system. The test methods are outlined stating with characterization tests, followed by life tests. The final section details standardized analysis techniques for 48 V systems that allow for the comparison of different programs that use this manual. An example test plan is included, along with guidance to filling in gap table numbers.

  3. Hybrid plasmonic-photonic resonators (Conference Presentation)

    Science.gov (United States)

    Koenderink, A. Femius; Doeleman, Hugo M.; Ruesink, Freek; Verhagen, Ewold; Osorio, Clara I.

    2016-09-01

    Hybrid nanophotonic structures are structures that integrate different nanoscale platforms to harness light-matter interaction. We propose that combinations of plasmonic antennas inside modest-Q dielectric cavities can lead to very high Purcell factors, yielding plasmonic mode volumes at essentially cavity quality factors. The underlying physics is subtle: for instance, how plasmon antennas with large cross sections spoil or improve cavities and vice versa, contains physics beyond perturbation theory, depending on interplays of back-action, and interferences. This is evident from the fact that the local density of states of hybrid systems shows the rich physics of Fano interferences. I will discuss recent scattering experiments performed on toroidal microcavities coupled to plasmon particle arrays that probe both cavity resonance shifts and particle polarizability changes illustrating these insights. Furthermore I will present our efforts to probe single plasmon antennas coupled to emitters and complex environments using scatterometry. An integral part of this approach is the recently developed measurement method of `k-space polarimetry', a microscopy technique to completely classify the intensity and polarization state of light radiated by a single nano-object into any emission direction that is based on back focal plane imaging and Stokes polarimetry. I show benchmarks of this technique for the cases of scattering, fluorescence, and cathodoluminescence applied to directional surface plasmon polariton antennas.

  4. Regenerative braking control strategy in mild hybrid electric vehicles equipped with automatic manual transmission

    Institute of Scientific and Technical Information of China (English)

    QIN Datong; YE Ming; LIU Zhenjun

    2007-01-01

    The actual regenerative braking force of an integrated starter/generator (ISG),which is varied with desired braking deceleration and vehicle speed,is calculated based on an analysis of the required deceleration,maximum braking force of ISG,engine braking force and state of charge (SOC) of battery.Braking force distribution strategies are presented according to the actual regenerative braking force of ISG.To recover the vehicle's kinetic energy maximally,braking shift rules for a mild hybrid electric vehicle (HEV) equipped with automatic manual transmission (AMT) are brought forward and effects of transmission ratios are considered.A test-bed is built up and regenerative braking tests are carried out.The results show that power recovered by the braking shift rules is more than that recovered by the normal braking control rules.

  5. Metallurgical and mechanical characterization of mild steel-mild steel joint formed by microwave hybrid heating process

    Indian Academy of Sciences (India)

    Amit Bansal; Apurbba Kumar Sharma; Shantanu Das

    2013-08-01

    In this paper, mild steel–mild steel (MS-MS) joints fabricated through microwave hybrid heating (MHH) have been characterized using X-ray diffraction (XRD), scanning electron microscope (SEM), electron probe micro analyser (EPMA), Vicker’s microhardness measurement and tensile strength. The XRD spectrum of the developed joints shows substitution type of solid solution form in the joint zone. The back scattered electron (BSE) images of the joint obtained by SEM show complete melting of powder particle and consequently diffusion bonding takes place between the substrate and the powder particle. The electron probe micro analysis shows diffusion of element across the joint. The Vicker’s micro hardness of the joints was measured to be 420 ± 30 Hv, which is higher than that of substrate hardness 230 ± 10 Hv. The tensile strength of the sample was measured by an universal testing machine and found to be 240 MPa which is about 50% of base material strength. The SEM micrographs of the fractured sample indicate mixed modes of failure during fracture of the joint; both ductile and brittle modes of failures occurred as indicated by dimple and cleavage of the brittle faces, respectively.

  6. Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo.

    Science.gov (United States)

    Al-Ahmady, Zahraa S; Al-Jamal, Wafa' T; Bossche, Jeroen V; Bui, Tam T; Drake, Alex F; Mason, A James; Kostarelos, Kostas

    2012-10-23

    The present study describes leucine zipper peptide-lipid hybrid nanoscale vesicles engineered by self-assembled anchoring of the amphiphilic peptide within the lipid bilayer. These hybrid vesicles aim to combine the advantages of traditional temperature-sensitive liposomes (TSL) with the dissociative, unfolding properties of a temperature-sensitive peptide to optimize drug release under mild hyperthermia, while improving in vivo drug retention. The secondary structure of the peptide and its thermal responsiveness after anchoring onto liposomes were studied with circular dichroism. In addition, the lipid-peptide vesicles (Lp-peptide) showed a reduction in bilayer fluidity at the inner core, as observed with DPH anisotropy studies, while the opposite effect was observed with an ANS probe, indicating peptide interactions with both the headgroup region and the hydrophobic core. A model drug molecule, doxorubicin, was successfully encapsulated in the Lp-peptide vesicles at higher than 90% efficiency following the remote loading, pH-gradient methodology. The release of doxorubicin from Lp-peptide hybrids in vitro indicated superior serum stability at physiological temperatures compared to lysolipid-containing temperature-sensitive liposomes (LTSL) without affecting the overall thermo-responsive nature of the vesicles at 42 °C. A similar stabilizing effect was observed in vivo after intravenous administration of the Lp-peptide vesicles by measuring (14)C-doxorubicin blood kinetics that also led to increased tumor accumulation after 24 h. We conclude that Lp-peptide hybrid vesicles present a promising new class of TSL that can offer previously unexplored opportunities for the development of clinically relevant mild hyperthermia-triggered therapeutic modalities.

  7. A mild route to mesoporous Mo2C-C hybrid nanospheres for high performance lithium-ion batteries

    Science.gov (United States)

    Gao, Qing; Zhao, Xinyu; Xiao, Ying; Zhao, Di; Cao, Minhua

    2014-05-01

    In this work, we have developed a mild route to fabricate typically mesoporous Mo2C-C hybrid nanospheres based on a solvothermal synthesis and reduction-carbonization process. This work opens a low-temperature route to synthesize valuable carbides. The resultant Mo2C-C hybrid, for the first time, is used as an anode material in lithium ion batteries (LIBs). Compared with bulk Mo2C, the Mo2C-C hybrid exhibits much better electrochemical performance. Remarkably, the hybrid electrode can deliver a specific capacity of over 670 mA h g-1 after 50 cycles at 100 mA g-1, which is much higher than that of the bulk material (113 mA h g-1). Even cycled at a high current density of 1000 mA g-1, high capacities of around 400-470 mA h g-1 can still be retained for the Mo2C-C hybrid. It might benefit from the synergistic effect of the nanohybridization, effectively relieving the volume change during the repeated lithium insertion-extraction reactions and maintaining the integrity of the electrical connections. It is expected that the present synthesis strategy for the Mo2C-C hybrid can be extended to other nanostructured carbides with good energy storage performance.In this work, we have developed a mild route to fabricate typically mesoporous Mo2C-C hybrid nanospheres based on a solvothermal synthesis and reduction-carbonization process. This work opens a low-temperature route to synthesize valuable carbides. The resultant Mo2C-C hybrid, for the first time, is used as an anode material in lithium ion batteries (LIBs). Compared with bulk Mo2C, the Mo2C-C hybrid exhibits much better electrochemical performance. Remarkably, the hybrid electrode can deliver a specific capacity of over 670 mA h g-1 after 50 cycles at 100 mA g-1, which is much higher than that of the bulk material (113 mA h g-1). Even cycled at a high current density of 1000 mA g-1, high capacities of around 400-470 mA h g-1 can still be retained for the Mo2C-C hybrid. It might benefit from the synergistic effect of

  8. ESTIMATE OF BURSTING PRESSURE OF MILD STEEL PRESSURE VESSEL AND PRESENTATION OF BURSTING FORMULA

    Institute of Scientific and Technical Information of China (English)

    ZHENG Chuanxiang

    2006-01-01

    In order to get more precise bursting pressure formula of mild steel, hundreds of bursting experiments of mild steel pressure vessels such as Q235(Gr.D) and 20R(1020) are done. Based on statistical data of bursting pressure and modification of Faupel formula, a more precise modified formula is given out according to the experimental data. It is proved to be more accurate after examining other bursting pressure value presented in many references. This bursting formula is very accurate in these experiments using pressure vessels with different diameter and shell thickness.Obviously, this modified bursting formula can be used in mild steel pressure vessels with different diameter and thickness of shell.

  9. Stressful Presentations: Mild Chronic Cold Stress in Mice Influences Baseline Properties of Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Kathleen Marie Kokolus

    2014-02-01

    Full Text Available The ability of dendritic cells to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especially in laboratory mice since they are used so heavily to study immune responses. Physiological stress is well recognized to impair several arms of immune protection. The goals of this report are to briefly summarize previous work revealing how DCs respond to various forms of physiologically relevant stress and to present new data highlighting the potential for chronic mild cold stress inherent in mice housed at standard ambient temperatures required for laboratory mice to influence baseline DCs properties. Since recent data from our group shows that CD8+ T cell function is altered by mild chronic cold stress and since DC function is crucial for CD8+ T cell activation, we wondered whether mild cold stress may also be influencing DC properties. We found increased numbers of splenic DCs (CD11c+ in cold stressed mice compared to mice housed at a thermoneutral temperature, which significantly reduces cold stress. However, many of the DCs which are expanded in cold stressed mice express an immature phenotype. We also found that antigen presentation and ability of splenocytes to activate T cells were impaired compared to that seen in DCs isolated from mice at thermoneutrality. The new data presented here strongly suggest that the housing temperature of mice can affect fundamental properties of DC function which in turn could be influencing the response of DCs to added experimental stressors or other treatments.

  10. The VRLA modular wound design for 42 V mild hybrid systems

    Science.gov (United States)

    Trinidad, F.; Gimeno, C.; Gutiérrez, J.; Ruiz, R.; Sainz, J.; Valenciano, J.

    Mild hybrid vehicles with 42 V electrical systems require advanced batteries with low cost, very high reliability and peak power performance. Valve-regulated lead-acid (VRLA) batteries could provide better performance/cost ratio than any other electrochemical couples, by improving their cycle life performance at partial state-of-charge (SoC), charge acceptance of the negative plate and thermal management under power assist conditions. Modular wound designs are being developed for this application, because they can combine the best attributes of the high power VRLA designs (low resistance and high compression) with a more efficient thermal management and could improve reliability by reducing the potential cell failures in manufacturing (better quality control could be assured for individual 3-cell modules than for complete 18-cell block batteries). Thermal management is an important issue for VRLA batteries in a power assist cycling profile. Although water cooling is very efficient, it is not economical and increases the weight of the complete storage system. The modular VRLA design allows air circulation around the external walls of every cell in order to maintain the temperature around 40 °C, even at very high power cycling profiles. In order to increase the life at higher depth-of-discharge (DoD) and consequently to optimise the weight of the complete battery systems, a new 6 V module has been designed with improved thermal management features. Cycle life performance under partial-SoC conditions (around 60% SoC) has been tested in both 6 and 12 V modules. The basic power assist profile as specified by the European car manufacturers is composed of a high power discharge (boost) period followed by a rest (cruise) and recharge in three steps (regenerative braking). Very good results have been obtained for 12 V VRLA spiral wound batteries under power assist profile (more than 200,000 cycles at 1.25% DoD, equivalent to 2500 times the nominal capacity), but smaller 6

  11. Predictors of Outcome in Patients Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores.

    Science.gov (United States)

    Kenmuir, Cynthia L; Hammer, Maxim; Jovin, Tudor; Reddy, Vivek; Wechsler, Lawrence; Jadhav, Ashutosh

    2015-07-01

    Although National Institutes of Health Stroke Scale (NIHSS) is a known predictor of outcome in acute ischemic stroke, there are other factors like age, ambulatory status, and ability to swallow that may be predictors of outcome but are not assessed by the traditional NIHSS. The aim of this retrospective review was to identify predictors of outcome in mild ischemic stroke. Discharge outcomes from patients who presented to our large academic stroke center with acute ischemic stroke from 2005 to 2013 were retrospectively reviewed. Of 7189 patients reviewed, 2597 had initial NIHSS less than 5. Outcome measures were modified Rankin Scale (MRS) score 0-1 and discharge to home. In all, 65% of patients with NIHSS 0-4 were discharged directly home independent of treatment. Of those patients discharged to home, 74% were able to ambulate independently and 98% passed their dysphagia screen. Of patients not discharged directly home, 66% were unable to ambulate independently and 21% did not pass their dysphagia screen. Multivariate logistic regression analysis revealed a significant effect of dysphagia screen (P = .001), ability to ambulate independently (P = .002), age (P = .016), and NIHSS (P = .005) on discharge to home but not MRS of 0-1 (P = .564). In patients with mild stroke scale scores defined as NIHSS 0-4, several factors including age, NIHSS, ambulatory status, and ability to swallow may be independent predictors of functional outcome and discharge home. These data support the development of a modified grading system for assessing functional outcome in mild stroke that considers these factors. Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  12. Mild clinical presentation in KLHL40-related nemaline myopathy (NEM 8).

    Science.gov (United States)

    Seferian, Andreea M; Malfatti, Edoardo; Bosson, Caroline; Pelletier, Laurent; Taytard, Jessica; Forin, Veronique; Gidaro, Teresa; Gargaun, Elena; Carlier, Pierre; Fauré, Julien; Romero, Norma B; Rendu, John; Servais, Laurent

    2016-10-01

    Nemaline myopathies are clinically and genetically heterogeneous muscle diseases characterized by the presence of nemaline bodies (rods) in muscle fibers. Mutations in the KLHL40 (kelch-like family member 40) gene (NEM 8) are common cause of severe/lethal nemaline myopathy. We report an 8-year-old girl born to consanguineous Moroccan parents, who presented with hypotonia and poor sucking at birth, delayed motor development, and further mild difficulties in walking and fatigability. A muscle biopsy revealed the presence of nemaline bodies. KLHL40 gene Sanger sequencing disclosed a never before reported pathogenic homozygous mutation which resulted in absent KLHL40 protein expression in the muscle. This further expands the phenotypical spectrum of KLHL40 related nemaline myopathy. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Presenting Symptoms and Dysphagia Screen Predict Outcome in Mild and Rapidly Improving Acute Ischemic Stroke Patients.

    Science.gov (United States)

    Gadodia, Gaurav; Rizk, Nibal; Camp, Deborah; Bryant, Katja; Zimmerman, Susan; Brasher, Cynthia; Connelly, Kerrin; Dunn, Joshua; Frankel, Michael; Ido, Moges Seymour; Lugtu, James; Nahab, Fadi

    2016-12-01

    There are limited data on which patients not treated with intravenous (IV) tissue-type plasminogen activator (tPA) due to mild and rapidly improving stroke symptoms (MaRISS) have unfavorable outcomes. Acute ischemic stroke (AIS) patients not treated with IV tPA due to MaRISS from January 1, 2009 to December 31, 2013 were identified as part of the Georgia Coverdell Acute Stroke Registry. Multivariable regression analysis was used to identify factors associated with a lower likelihood of favorable outcome, defined as discharge to home. There were 1614 AIS patients who did not receive IV tPA due to MaRISS (median National Institutes of Health stroke scale [NIHSS] 1], of which 305 (19%) did not have a favorable outcome. Factors associated with lower likelihood of favorable outcome included Medicare insurance status (odds ratio [OR]: .53, 95% confidence interval [CI]: .34-.84), arrival by emergency medical services (OR: .46, 95% CI: .29-.73), increasing NIHSS score (per unit OR: .89, 95% CI: .84-.93), weakness as the presenting symptom (OR: .50, 95% CI: .30-.84), and a failed dysphagia screen (OR: .43, 95% CI: .23-.80). During the study period, dysphagia screen identify a subgroup of patients who are more likely to have an unfavorable outcome. Whether IV tPA treatment can improve the outcome in this subgroup of patients needs to be evaluated in a randomized placebo-controlled trial. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  14. Microstructure and Mechanical Properties of Narrow Gap Laser-Arc Hybrid Welded 40 mm Thick Mild Steel

    Science.gov (United States)

    Zhang, Chen; Li, Geng; Gao, Ming; Zeng, XiaoYan

    2017-01-01

    Both laser-arc hybrid welding and narrow gap welding have potential for the fabrication of thick sections, but their combination has been seldom studied. In this research, 40 mm thick mild steel was welded by narrow gap laser-arc hybrid welding. A weld with smooth layer transition, free of visible defects, was obtained by nine passes at a 6 mm width narrow gap. The lower part of the weld has the lowest mechanical properties because of the lowest amount of acicular ferrite, but its ultimate tensile strength and impact absorbing energy is still 49% and 60% higher than those of base metal, respectively. The microhardness deviation of all filler layers along weld thickness direction is no more than 15 HV0.2, indicating that no temper softening appeared during multiple heat cycles. The results provide an alternative technique for improving the efficiency and quality of welding thick sections. PMID:28772469

  15. Microstructure and Mechanical Properties of Narrow Gap Laser-Arc Hybrid Welded 40 mm Thick Mild Steel

    Directory of Open Access Journals (Sweden)

    Chen Zhang

    2017-01-01

    Full Text Available Both laser-arc hybrid welding and narrow gap welding have potential for the fabrication of thick sections, but their combination has been seldom studied. In this research, 40 mm thick mild steel was welded by narrow gap laser-arc hybrid welding. A weld with smooth layer transition, free of visible defects, was obtained by nine passes at a 6 mm width narrow gap. The lower part of the weld has the lowest mechanical properties because of the lowest amount of acicular ferrite, but its ultimate tensile strength and impact absorbing energy is still 49% and 60% higher than those of base metal, respectively. The microhardness deviation of all filler layers along weld thickness direction is no more than 15 HV0.2, indicating that no temper softening appeared during multiple heat cycles. The results provide an alternative technique for improving the efficiency and quality of welding thick sections.

  16. Very mild presentation in adult with classical cellular phenotype of ataxia telangiectasia.

    Science.gov (United States)

    Worth, Paul F; Srinivasan, Venkataramanan; Smith, Anna; Last, James I; Wootton, Laura L; Biggs, Paul M; Davies, Nicholas P; Carney, Ellen F; Byrd, Philip J; Taylor, A Malcolm R

    2013-04-01

    The major clinical feature of ataxia telangiectasia (A-T) is severe progressive neurodegeneration with onset in infancy. This classical A-T phenotype is caused by biallelic null mutations in the ATM gene, leading to the absence of ATM protein and increased cellular radiosensitivity. We report an unusual case of A-T in a 41-year-old mother, A-T210, who had very mild neurological symptoms despite complete loss of ATM protein. A neurological examination was performed, cellular radiosensitivity was assessed, and the ATM gene was sequenced. Skin fibroblasts and a lymphoblastoid cell line (LCL) were assayed for ATM protein expression and kinase activity. Patient A-T210 showed mild chorea, dystonia, and gait ataxia, walked independently, and drove a car. LCL and skin fibroblasts were radiosensitive and did not express ATM protein. Two ATM-null mutations were identified. The severe neurodegeneration resulting from loss of ATM can be mitigated in some circumstances. Copyright © 2012 Movement Disorders Society.

  17. Pallister-Killian syndrome: A mild case diagnosed by fluorescence in situ hybridization. Review of the literature and expansion of the phenotype

    Energy Technology Data Exchange (ETDEWEB)

    Bielanska, M.M.; Khalifa, M.M.; Duncan, A.M.V. [Queen`s Univ., Kingston, Ontario (Canada)

    1996-10-16

    Pallister-Killian syndrome (PKS) is a rare disorder characterized by a specific combination of anomalies, mental retardation and mosaic presence of a supernumerary isochromosome 12p which is tissue-limited. We report an atypical case of PKS with a mild phenotype. Fluorescence in situ hybridization (FISH) was used to demonstrate that the supernumerary marker chromosome identified in the patient`s fibroblasts was an isochromosome 12p. This study broadens the spectrum of PKS phenotype. It also illustrates the usefulness of fluorescence in situ hybridization in diagnosis of patients with chromosomal abnormalities and mild or atypical clinical findings. 40 refs., 2 figs., 1 tab.

  18. Brain MRI findings in patients with mucopolysaccharidosis types I and II and mild clinical presentation

    Energy Technology Data Exchange (ETDEWEB)

    Matheus, M.Gisele; Castillo, Mauricio; Smith, J. Keith [Department of Radiology, University of North Carolina School of Medicine, 27599-7510, Chapel Hill, NC (United States); Armao, Diane [Department of Pathology, University of North Carolina School of Medicine, Chapel Hill, NC (United States); Towle, Diane; Muenzer, Joseph [Department of Genetics and Metabolism, University of North Carolina School of Medicine, Chapel Hill, NC (United States)

    2004-08-01

    Our objective was to determine the brain magnetic resonance imaging (MRI) abnormalities in a selected group of patients with mucopolysaccharidosis (MPS) types I and II who had only mild clinical manifestations. We retrospectively assessed MRI brain studies in 18 patients with MPS (type I: 6 and type II: 12). We evaluated abnormal signal intensity in the white matter, widening of the cortical sulci, size of the supratentorial ventricles, dilatation of the perivascular spaces (PVS) and enlargement of the subarachnoid spaces. We observed a broad spectrum of findings, and despite severely abnormal MRI studies, no patients had mental retardation. We also observed that dilated PVS, previously believed to be caused by macroscopic deposition of the mucopolysaccharides, had an appearance similar to cerebrospinal fluid (CSF) in all MRI sequences performed, even in FLAIR and trace diffusion weighted images. Based on our results, we believe that with the exception of white matter abnormalities and brain atrophy, all other findings may be related to abnormal resorption of CSF, and there is no relationship between the imaging and clinical manifestations of the disease. (orig.)

  19. OCT imaging of acute vascular changes following mild traumatic brain injury in mice (Conference Presentation)

    Science.gov (United States)

    Chico-Calero, Isabel; Shishkov, Milen; Welt, Jonathan; Blatter, Cedric; Vakoc, Benjamin J.

    2016-03-01

    While most people recover completely from mild traumatic brain injuries (mTBIs) and concussions, a subset develop lasting neurological disorders. Understanding the complex pathophysiology of these injuries is critical to developing improved prognostic and therapeutic approaches. Multiple studies have shown that the structure and perfusion of brain vessels are altered after mTBI. It is possible that these vascular injuries contribute to or trigger neurodegeneration. Intravital microscopy and mouse models of TBI offer a powerful platform to study the vascular component of mTBI. Because optical coherence tomography based angiography is based on perfusion contrast and is not significantly degraded by vessel leakage or blood brain barrier disruption, it is uniquely suited to studies of brain perfusion in the setting of trauma. However, existing TBI imaging models require surgical exposure of the brain at the time of injury which conflates TBI-related vascular changes with those caused by surgery. In this work, we describe a modified cranial window preparation based on a flexible, transparent polyurethane membrane. Impact injuries were delivered directly through this membrane, and imaging was performed immediately after injury without the need for additional surgical procedures. Using this model, we demonstrate that mTBI induces a transient cessation of flow in the capillaries and smaller vessels near the injury point. Reperfusion is observed in all animals within 3 hours of injury. This work describes new insight into the transient vascular changes induced by mTBI, and demonstrates more broadly the utility of the OCT/polyurethane window model platform in preclinical studies of mTBI.

  20. A functionalized phosphonate-rich organosilica layered hybrid material (PSLM) fabricated through a mild process for heavy metal uptake

    Energy Technology Data Exchange (ETDEWEB)

    Daikopoulos, Chris [Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110 (Greece); Bourlinos, Athanasios B. [Institute of Materials Science, NCSR “Demokritos”, Ag. Paraskevi Attikis, Athens 15310 (Greece); Georgiou, Yiannis [Laboratory of Physical Chemistry, Department of Environmental and Natural Resources Management, University of Patras, Seferi 2, Agrinio 30100 (Greece); Deligiannakis, Yiannis, E-mail: ideligia@cc.uoi.gr [Laboratory of Physical Chemistry, Department of Environmental and Natural Resources Management, University of Patras, Seferi 2, Agrinio 30100 (Greece); Zboril, Radek [Regional Centre of Advanced Technologies and Materials, Faculty of Science, Department of Physical Chemistry and Experimental Physics, Palacky University, Olomouc 77146 (Czech Republic); Karakassides, Michael A. [Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110 (Greece)

    2014-04-01

    Highlights: • Novel phosphonate-rich organosilica layered hybrid material (PSLM) fabricated through a mild xerogel process. • Surface Complexation Modeling reveals that PSLM bears 2 types of functional groups able to bind heavy metal. • Maximum metal uptake capacities were found 2.72 mmol g{sup −1} for Cu{sup 2+}, 1.67 mmol g{sup −1} for Pb{sup 2+} and 1.00 mmol g{sup −1} for Cd{sup 2+} at pH 7. • EPR spectroscopy reveals local coordination environment for Cu{sup 2+} ions. - Abstract: A phosphonate-rich organosilica layered hybrid material (PSLM) made of 3-(trihydroxysilyl)propyl methylphosphonate, monosodium salt, as the single silica source, has been obtained from its aqueous solution through a xerogel process and mild thermal aging. The method is simple, affording bulk quantities of powdered PSLM in a single-step. The hybrid is stable in water and possesses a high content of phosphonate groups fixed on the solid matrix. In addition, PSLM shows good thermal stability, which exceeds 300 °C in air. The material was characterized using SEM, TEM, XRD, FT-IR and TGA techniques. Potentiometric titrations show that PSLM bears high-surface density of phosphonate groups (3 mmol g{sup −1}). As a result, the material displays high metal uptake capacity for heavy metal ions such as Cu{sup 2+} (2.72 mmol g{sup −1}), Pb{sup 2+} (1.67 mmol g{sup −1}) and Cd{sup 2+} (1.00 mmol g{sup −1}) at neutral pH values e.g. the pH of natural waters. Detailed theoretical modeling using a Surface Complexation Model combined with Electron Paramagnetic Resonance (EPR) spectroscopy shows that the surface distribution of surface bound Cu{sup 2+} ions is rather homogeneous e.g. copper-binding phosphonate sites are arranged in average distances 5–8 Å.

  1. Deficits in narrative discourse elicited by visual stimuli are already present in patients with mild cognitive impairment

    Science.gov (United States)

    Drummond, Cláudia; Coutinho, Gabriel; Fonseca, Rochele Paz; Assunção, Naima; Teldeschi, Alina; de Oliveira-Souza, Ricardo; Moll, Jorge; Tovar-Moll, Fernanda; Mattos, Paulo

    2015-01-01

    Language batteries used to assess the skills of elderly individuals, such as naming and semantic verbal fluency, present some limitations in differentiating healthy controls from patients with amnestic mild cognitive impairment (a-MCI). Deficits in narrative discourse occur early in dementia caused by Alzheimer's disease (AD), and the narrative discourse abilities of a-MCI patients are poorly documented. The present study sought to propose and evaluate parameters for investigating narrative discourse in these populations. After a pilot study of 30 healthy subjects who served as a preliminary investigation of macro- and micro-linguistic aspects, 77 individuals (patients with AD and a-MCI and a control group) were evaluated. The experimental task required the participants to narrate a story based on a sequence of actions visually presented. The Control and AD groups differed in all parameters except narrative time and the total number of words recalled. The a-MCI group displayed mild discursive difficulties that were characterized as an intermediate stage between the Control and AD groups' performances. The a-MCI and Control groups differed from the AD group with respect to global coherence, discourse type and referential cohesion. The a-MCI and AD groups were similar to one another but differed from the Control group with respect to the type of words recalled, the repetition of words in the same sentence, the narrative structure and the inclusion of irrelevant propositions in the narrative. The narrative parameter that best distinguished the three groups was the speech effectiveness index. The proposed task was able to reveal differences between healthy controls and groups with cognitive decline. According to our findings, patients with a-MCI already present narrative deficits that are characterized by mild discursive difficulties that are less severe than those found in patients with AD. PMID:26074814

  2. Deficits in narrative discourse elicited by visual stimuli are already present in patients with Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Cláudia eDrummond

    2015-05-01

    Full Text Available Language batteries used to assess the skills of elderly individuals, such as naming and semantic verbal fluency, present some limitations in differentiating healthy controls from patients with amnestic mild cognitive impairment (a-MCI. Deficits in narrative discourse occur early in dementia caused by Alzheimer’s disease (AD, and the narrative discourse abilities of a-MCI patients are poorly documented. The present study sought to propose and evaluate parameters for investigating narrative discourse in these populations. After a pilot study of 30 healthy subjects who served as a preliminary investigation of macro- and microlinguistic aspects, 77 individuals (patients with AD and a-MCI and a control group were evaluated. The experimental task required the participants to narrate a story based on a sequence of actions visually presented. The Control and AD groups differed in all parameters except narrative time and the total number of words recalled. The a-MCI group displayed mild discursive difficulties that were characterized as an intermediate stage between the Control and AD groups’ performances. The a-MCI and Control groups differed from the AD group with respect to global coherence, discourse type and referential cohesion. The a-MCI and AD groups were similar to one another but differed from the Control group with respect to the type of words recalled, the repetition of words in the same sentence, the narrative structure and the inclusion of irrelevant propositions in the narrative. The narrative parameter that best distinguished the three groups was the speech effectiveness index. The proposed task was able to reveal differences between healthy controls and groups with cognitive decline. According to our findings, patients with a-MCI already present narrative deficits that are characterized by mild discursive difficulties that are less severe than those found in patients with AD.

  3. Mild Clinical Presentation of Acute Fatty Liver in the Second Trimester of Pregnancy

    Directory of Open Access Journals (Sweden)

    Alaeddine Yassin

    2011-01-01

    Full Text Available We report a case of 29 years old woman who was diagnosed with acute fatty liver of pregnancy at 23 weeks of gestation with unusual evolution (pregnancy prolonged until 36 weeks of gestation to draw attention on the possibility of occurrence of this pathology in the second trimester of pregnancy even with a milder clinical presentation and course.

  4. Canavan disease - unusual imaging features in a child with mild clinical presentation

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Ho V.; Ishak, Gisele E. [University of Washington, Department of Radiology, Seattle Children' s Hospital, Seattle, WA (United States)

    2015-03-01

    Canavan disease is a rare hereditary leukodystrophy that manifests in early childhood. Associated with rapidly progressive clinical deterioration, it usually results in death by the third year of life. The predominant MRI appearance is diffuse and symmetrical white matter disease. We discuss an atypical, late presentation of Canavan disease with a benign clinical course and uncharacteristic imaging features. This case introduces a previously unreported pattern of diffuse cortical abnormality without significant white matter involvement. (orig.)

  5. Hybrid Treatment of Acute Abdominal Aortic Thrombosis Presenting with Paraplegia.

    Science.gov (United States)

    Azzarone, Matteo; De Troia, Alessandro; Iazzolino, Luigi; Nabulsi, Bilal; Tecchio, Tiziano

    2016-05-01

    Acute thrombotic or embolic occlusion of the abdominal aorta is a rare vascular emergency associated with high morbidity and mortality rates. Classically, the clinical presentation is a severe peripheral ischemia with bilateral leg pain as the predominant feature. Aortic occlusion presenting as an isolated acute onset of paraplegia due to spinal cord ischemia is very rare and requires improved awareness to prevent adverse outcomes associated with delayed diagnosis. We report the case of a 54-year-old man who presented with sudden paraplegia due to the thrombotic occlusion of the infrarenal aorta involving the first segment of the common iliac arteries on both sides; emergent transperitoneal aorto iliac thrombectomy combined with the endovascular iliac kissing-stent technique were performed achieving perioperative complete regression of the symptoms.

  6. Hybrid nanocomposite from aniline and CeO2 nanoparticles: Surface protective performance on mild steel in acidic environment

    Science.gov (United States)

    Sasikumar, Y.; Kumar, A. Madhan; Gasem, Zuhair M.; Ebenso, Eno E.

    2015-03-01

    This present work contributes to the development of a new generation of active corrosion inhibitors composed of CeO2 nanoparticles covered with polyaniline that are able to release entrapped nanoparticles in acidic medium. Nanocomposites of aniline and CeO2 nanoparticles have been chemically synthesized by in-situ polymerization. The structural evolutions and morphological characteristics of PANI/CeO2 nanocomposite (PCN) have performed using various techniques such as XRD, IR, XPS, SEM and TEM analysis. It was illustrated from SEM and TEM observation that the PCN has globular particle with core-shell structure. The inhibition properties of synthesized PCN on mild steel (MS) corrosion in 0.5 M HCl were estimated using weight loss and electrochemical techniques. Potentiodynamic polarization results revealed PCN to be a mixed-type inhibitor, while impedance results indicate the adsorption of the PCN film on the MS surface. The inhibition efficiency of PCN was found to increase almost linearly with concentration. Moreover, an increase in the water contact-angle with PCN indicated its adsorption at the MS surface, and ATR-IR, SEM/EDAX and AFM visualization confirmed the formation of a protective film adsorbed on a MS surface. Finally, it was concluded that the PCN is a potential inhibitor for mild steel in HCl medium.

  7. Characterization of SiO2-TiO2 Hybrid Corrosion Protective Coatings on Mild Steel

    Science.gov (United States)

    Kirtay, Sebahattin

    2014-12-01

    Organic-inorganic SiO2-TiO2 sol-gel coatings were prepared and applied on a mild steel substrate using dip coating technique and subsequently heat treated at 200 and 300 °C to improve the corrosion resistance. The coating sols were synthesized using Glycidoxytrimethoxysilane and titanium tetraisopropoxide as precursor materials. The corrosion resistances of the both coated and uncoated samples were evaluated by the Tafel polarization and electrochemical impedance spectroscopy in NaCl solution. The microstructure of coated specimens was characterized by scanning electron microscopy. Fourier transformed infrared and energy dispersive spectroscopy analyses were used to identify the presence of various functional groups in the coating solutions. A comparison of the corrosion resistance of the coated and uncoated mild steel was presented. i corr values of coated specimens heat treated at 200 °C were between 6.9 and 9.2 times smaller than those of uncoated specimen. In the case of coated specimens heat treated at 300 °C, i corr values were 4.4 and 5 times smaller than those of uncoated specimen. The coating film was noted to be smooth and between 7.2- and 7.5-µm thick. The measured electrochemical parameters indicated that the corrosion resistance was improved by the coating film. The elasticity of the coating can be improved by the presence of organic groups in the coating which reduces stress and crack formations during sintering. Ultimately, crack-free and elastic coating was obtained by heat treating of organic-inorganic coating at as low as 200 °C.

  8. Paraneoplastic Pemphigus Presenting as Mild Cutaneous Features of Pemphigus Foliaceus and Lichenoid Stomatitis with Antidesmoglein 1 Antibodies

    Directory of Open Access Journals (Sweden)

    Yayoi Niimi

    2010-01-01

    Full Text Available Herein, we report a case of paraneoplastic pemphigus with mild skin features of pemphigus foliaceus and lichenoid stomatitis associated with B-cell lymphoma. A 49-year-old man presented with scattered blisters and erosions on the trunk along with mucosal blisters and erosions. Skin biopsy showed subcorneal acantholytic bulla and oral mucosal biopsy demonstrated lichenoid dermatitis. Direct immunofluorescence showed cell surface deposits of IgG and C3. Indirect immunofluorescence identified circulating IgG autoantibodies to the cell surfaces of normal human skin and also on the transitional epithelium of rat bladder. Enzyme-linked immunosorbent assay using recombinant baculoproteins showed positive antidesmoglein 1 autoantibodies (index 46 but negative antidesmoglein 3 autoantibodies (index 8. Immunoblot analysis using normal human epidermal extract detected BP230 and the 190 kDa periplakin, while immunoprecipitation using radiolabeled cultured keratinocyte immunoprecipitated BP230 and the 210 kDa envoplakin. We consider that the skin lesion was produced by humoral immunity whereas the oral lesion was produced by cellular immunity.

  9. 超轻度混合动力传动系统建模和仿真%Modeling and simulation of super-mild hybrid transmission system

    Institute of Scientific and Technical Information of China (English)

    惠金芹; 郭家田; 张伯俊

    2012-01-01

    分析超轻度混合动力汽车及其传动系统,采用键合图理论,建立了超轻度混合动力汽车高速纯无级调速工况下的整车传动系统键合图模型,列出高速挡传动系统的状态方程.建立整车控制仿真模型,制定高速挡控制策略并进行了仿真分析.%The paper analyzes the super-mild hybrid electric vehicle and its transmission system, and by the bond graph theory, the whole machine bond graph model of the super-mild hybrid electric vehicle under the high-speed pure stepless speed regulating condition is established, with the state equation for high-speed transmission system formed. The simulation model for whole vehicle control is established, and high-speed block control strategy is formulated, with simulation analysis as well in the paper.

  10. Synthèse du Projet Mild-Hybrid. Simulation et implémentation sur banc moteur de trois configurations hybrides parallèles à 2 embrayages.

    OpenAIRE

    Trigui, Rochdi; Jeanneret, Bruno; MALAQUIN, Bertrand; Badin, François

    2007-01-01

    Le projet MILDHYBRID associant l'INRETS-LTE et Valeo a commencé en 2001 et s'est terminé en 2007. L'objectif de ce projet était l'identification des potentiels en terme de réduction de consommation de carburant (et donc de CO2) d'un véhicule hybride parallèle à deux embrayages présentant un taux d'hybridation moyen (mild). Ce projet a été abordé en deux phases pour étudier 3 configurations de la chaîne électrique : - Phase 1 : moteur électrique MARS de Valéo (à base d'un alternateur à griffe)...

  11. Controllable wave propagation of hybrid dispersive medium with LC high-pass network (Conference Presentation)

    Science.gov (United States)

    Flores Parra, Edgar; Bergamini, Andrea E.; Ermanni, Paolo

    2017-04-01

    This work reports on the wave transmission characteristics of a hybrid one dimensional (1D) medium. The hybrid characteristic is the result of the coupling between a mechanical waveguide in the form of an elastic beam, and an electrical network. The network configuration investigated is an LC high-pass, consisting of a series of capacitors connected in series through grounded inductors. The capacitors correspond to a periodic array of piezoelectric patches that are bonded to the beam thus coupling the two waveguides. The coupling is characterized by a coincidence frequency/wavenumber corresponding to the intersection of the dispersion curves. At this coincidence frequency, the hybrid medium features attenuation of wave motion as a result of the energy transfer to the electrical network. This energy exchange is depicted in the dispersion by eigenvalue crossing, a particular case of eigenvalue veering. This paper presents the numerical investigations of the wave propagation in the considered medium, and validates the numerical findings with experimental evidence of the wave transmission characteristics. Moreover, the dispersion properties of the electrical network are further studied by varying the inductances thus exploiting the tunability of the periodic electrical domain, i.e: monoatomic and diatmomic unit cell configurations. The LC high-pass network offers several advantages over other configurations, from ease of implementation as the piezoelectric elements are not grounded, to a smaller inductance values to achieve attenuation at a given frequency. Such media could be interfaced with more complex electrical networks to create a new type of smart materials.

  12. Tunable high-refractive index hybrid for solution-processed light management devices (Conference Presentation)

    Science.gov (United States)

    Bachevillier, Stefan

    2016-10-01

    After the use of highly efficient but expensive inorganic optical materials, solution-processable polymers and hybrids have drawn more and more interest. Our group have recently developed a novel polymer-based hybrid optical material from titanium oxide hydrate exhibiting an outstanding set of optical and material properties. Firstly, their low cost, processability and cross-linked states are particularly attractive for many applications. Moreover, a high refractive index can be repeatedly achieved while optical losses stays considerably low over the entire visible and near-infrared wavelength regime. Indeed, the formation of inorganic nanoparticles, usually present in nanocomposites, is avoided by a specific formulation process. Even more remarkably, the refractive index can be tuned by either changing the inorganic content, using different titanium precursors or via a low-temperature curing process. A part of our work is focused on the reliable optical characterization of these properties, in particular a microscope-based setup allowing in-situ measurement and sample mapping has been developed. Our efforts are also concentrated on various applications of these exceptional properties. This hybrid material is tailored for photonic devices, with a specific emphasis on the production of highly efficient solution processable Distributed Bragg Reflectors (DBR) and anti-reflection coatings. Furthermore, waveguides can be fabricated from thin films along with in-coupling and out-coupling structures. These light managements structures are particularly adapted to organic photovoltaic cells (OPVs) and light emitting diodes (OLEDs).

  13. PRESENT STATE AND POSSIBILITIES OF MAIZE HYBRIDS SEED PRODUCTION WITH THE REVIEW ON THE EXPORT

    Directory of Open Access Journals (Sweden)

    Branimir Šimić

    2004-06-01

    Full Text Available The present seed production of maize in the Republic of Croatia is reduced in relation to the period before the Patriotic War. Production of maize seed in Croatia was between 14,000 and 21,000 tons yearly in the period from 1981 to 1986. It was reduced to 8000 tons yearly in the period from 1989 to 2001. Today, Croatia has 13 processing centres with the capacity approximately 50,000 tons of seed, but utilisation of these capacities is about 40%. Decreasing of maize seed production is caused by market reduction (less areas under the maize in Croatia and reduced export of maize hybrids seed. Before the Patriotic War, Croatia participated in the total seeds export of former Yugoslavia with 35-40%. The largest export of maize seed was 1983, with the approximately 10,700 tons. Seed export of Bc, Os and KWS hybrids was the Eastern European market, while the seed of Pioneer, SES and part of KWS hybrids was exported on the Western European market. Nowadays, production of maize hybrids at Croatia is about 5000 ha (in the world on about 1 mil. ha with the seed export of 3500 tons, approximately. Today, the largest amount of maize seed is exported in Spain, Germany, Italy, Portugal, Bosnia and Herzegovina, Macedonia, Slovenia and Turkey. The total value of maize seed production is 20 mil. Euro, approximately. Seed export should be the basic strategic aim in the program of seed production development because areas occupied with mercantile maize (approximately 400,000 ha cannot completely employ capacities for the production of seed.

  14. Subglottic Chondrosarcoma Presenting Only Mild Acute-Onset Dyspnea: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Su-wei Tsai

    2014-01-01

    Full Text Available Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. We report the case of a 68-year-old man with chondrosarcoma in the subglottic area. His chief symptoms were hoarseness and mild dysphagia. A computed tomography scan revealed a lesion with expansion of the cricoid cartilage and marked reduction of the airway. After biopsy, histological inspection showed that chondrocytes are multi-nucleus, their size does not differ much and mitosis is not obvious. These are all characteristics of a low-grade chondrosarcoma. We performed an organ-preserving operation by debulking the low-grade malignant tumor in order to keep a patent airway. No further metastasis or airway compromise was evident during the 1-year follow-up visit.

  15. Electromagnetic Comparison of 3-, 5- and 7-phases Permanent-Magnet Synchronous Machines : Mild Hybrid Traction Application

    Directory of Open Access Journals (Sweden)

    D. Ouamara

    2016-09-01

    Full Text Available Authors compare the electromagnetic performances of three multi-phases permanent-magnet (PM synchronous machines (PMSM for Mild Hybridtraction application. This comparison was made using two-dimensional (2-D numerical simulations in transient magnetic with eddy-current reaction field in the PMs. The best machine was determined using an energetic analysis (i.e., losses, torque and efficiency according specifications. In this study, the non-overlapping winding with double layer (i.e. all teeth wound type was used. The winding synthesis is based on the "Star of slots" method as well as the Fourier series decomposition of the magnetomotive force (MMF.

  16. CHARGE-like presentation, craniosynostosis and mild Mowat-Wilson Syndrome diagnosed by recognition of the distinctive facial gestalt in a cohort of 28 new cases.

    Science.gov (United States)

    Wenger, Tara L; Harr, Margaret; Ricciardi, Stefania; Bhoj, Elizabeth; Santani, Avni; Adam, Margaret P; Barnett, Sarah S; Ganetzky, Rebecca; McDonald-McGinn, Donna M; Battaglia, Domenica; Bigoni, Stefania; Selicorni, Angelo; Sorge, Giovanni; Monica, Matteo Della; Mari, Francesca; Andreucci, Elena; Romano, Silvia; Cocchi, Guido; Savasta, Salvatore; Malbora, Baris; Marangi, Giuseppe; Garavelli, Livia; Zollino, Marcella; Zackai, Elaine H

    2014-10-01

    Mowat-Wilson syndrome (MWS) is characterized by moderate to severe intellectual disability and distinctive facial features in association with variable structural congenital anomalies/clinical features including congenital heart disease, Hirschsprung disease, hypospadias, agenesis of the corpus callosum, short stature, epilepsy, and microcephaly. Less common clinical features include ocular anomalies, craniosynostosis, mild intellectual disability, and choanal atresia. These cases may be more difficult to diagnose. In this report, we add 28 MWS patients with molecular confirmation of ZEB2 mutation, including seven with an uncommon presenting feature. Among the "unusual" patients, two patients had clinical features of charge syndrome including choanal atresia, coloboma, cardiac defects, genitourinary anomaly (1/2), and severe intellectual disability; two patients had craniosynostosis; and three patients had mild intellectual disability. Sixteen patients have previously-unreported mutations in ZEB2. Genotype-phenotype correlations were suggested in those with mild intellectual disability (two had a novel missense mutation in ZEB2, one with novel splice site mutation). This report increases the number of reported patients with MWS with unusual features, and is the first report of MWS in children previously thought to have CHARGE syndrome. These patients highlight the importance of facial gestalt in the accurate identification of MWS when less common features are present. © 2014 Wiley Periodicals, Inc.

  17. Hybrid passive-active modal networks for structural acoustic control (Conference Presentation)

    Science.gov (United States)

    Cunefare, Kenneth A.; Lossouarn, Boris; Collet, Manuel

    2017-04-01

    Distributions of piezoelectric patches bonded to structures provide a means to alter or control, through active or passive means, the dynamic response of the host structure. Numerous active control schemes for such composite structures have been explored. Alternatively, for certain structures, a passive electrical network may be implemented which presents an electrical analog of the modal response of the structure, effectively providing a multi-modal, distributed passive tuned mass modal damper capability. Numerous tuned-mass damper design concepts ("tunings") may be applied to such a passive network. Further, the distributed network analog, when coupled with active control concepts, permits a hybrid distributed passive-active modal control capability. This paper explores this hybrid distributed network control concept applied to a clamped rectangular plate. A unit-cell discrete representation of the plate leads to an electrical analog comprised of passive inductors, transformers and resistors. Addition of synthetic (or controlled) impedances at a limited set of points within the network permits dynamic adjustment of the frequency response of the system.

  18. Alcohol-Selective Oxidation in Water under Mild Conditions via a Novel Approach to Hybrid Composite Photocatalysts.

    Science.gov (United States)

    Abd-Elaal, Ali; Parrino, Francesco; Ciriminna, Rosaria; Loddo, Vittorio; Palmisano, Leonardo; Pagliaro, Mario

    2015-12-01

    The oxidation of alcohols to carbonyl compounds in a clean fashion (i.e., with water as a solvent or under solvent-free conditions, and using O2 or H2O2 as the primary oxidant) is the subject of considerable research efforts. A new approach for the selective oxidation of soluble aromatic alcohols in water under mild conditions via a novel composite photocatalyst has been developed. The catalyst is synthesized by grafting 4-(4-(4-hydroxyphenylimino)cyclohexa-2,5dienylideneamino)phenol and silver nanoparticles onto the surface of moderately crystalline titanium dioxide. The titanium dioxide-based composite was first extensively characterized and then employed in the catalytic oxidation of 4-methoxybenzyl alcohol to 4-methoxybenzaldehyde under UV irradiation in water at room temperature. The corresponding aldehyde was obtained with unprecedented high selectivity (up to 86 %). The method is general and opens the route to fabrication of photocatalytic composites based on titanium dioxide functionalized with shuttle organic molecules and metal nanoparticles for a variety of oxidative conversions.

  19. Two novel RAD21 mutations in patients with mild Cornelia de Lange syndrome-like presentation and report of the first familial case.

    Science.gov (United States)

    Minor, Agata; Shinawi, Marwan; Hogue, Jacob S; Vineyard, Marisa; Hamlin, Damara R; Tan, Christopher; Donato, Kirsten; Wysinger, Latrice; Botes, Shaun; Das, Soma; Del Gaudio, Daniela

    2014-03-10

    Cornelia de Lange syndrome (CdLS) is a developmental disorder characterized by limb reduction defects, characteristic facial features and impaired cognitive development. Mutations in the NIPBL gene predominate; however, mutations in other cohesin complex genes have also been implicated, particularly in atypical and mild CdLS cases. Missense mutations and whole gene deletions in RAD21 have been identified in children with growth retardation, minor skeletal anomalies and facial features that overlap findings in individuals with CdLS. We report the first intragenic deletion and frameshift mutations identified in RAD21 in two patients presenting with atypical CdLS. One patient had an in-frame deletion of exon 13, while the second patient had a c.592_593dup frameshift mutation. The first patient presented with developmental delay, hypospadias, inguinal hernia and dysmorphic features while, the second patient presented with developmental delay, characteristic facial features, hirsutism, and hand and feet anomalies, with the first patient being milder than the second. The in-frame deletion mutation was found to be inherited from the mother who had a history of melanoma and other unspecified medical problems. This study expands the spectrum of RAD21 mutations and emphasizes the clinical utility of performing RAD21 mutation analysis in patients presenting with atypical forms of CdLS. Moreover, the variability of clinical presentation within families and low penetrance of mutations as well as the significance of performing molecular genetic testing in mildly affected patients are discussed. Published by Elsevier B.V.

  20. Presentation and Performance Evaluation of a Novel Stator-Permanent-Magnet Hybrid Stepping Motor

    Directory of Open Access Journals (Sweden)

    Binglin Lu

    2017-05-01

    Full Text Available In this paper, a new type of hybrid stepping motor (HSM with permanent magnets (PMs embedded in the stator, namely the stator-permanent-magnet hybrid stepping motor (SHSM, is presented. It has the same operation principles as the traditional HSM, with a 2-D distributed magnetic field nature and superiorities such as simpler rotor structure, easier PM cooling, higher torque and power density, and higher power grade. Its structural topology and operation principles are initially presented. Then an investigation on the performance comparison between the HSM and the SHSM, in terms of PM flux density, PM torque, detent torque, positional holding accuracy, stator core saturation issue, PM flux leakage, and PM utilization rate is carried out theoretically to make an assessment of the performance superiorities of the SHSM. A prototype of a 2-phase 8-pole 50-rotor-tooth SHSM is fabricated and experimentally compared with the HSM by using finite element analysis (FEA to verify the motor’s operational feasibility and the theoretical analysis. The FEA and experimental results show that the proposed SHSM has performance advantages such as higher torque density, higher power grade, and higher pull-out torque, holding torque, and torque-speed property, although it has performance defects such as higher torque ripple and relatively lower positional holding accuracy in the open-loop operation than the conventional HSM. Consequently, this novel SHSM is more suitable for electromechanical energy conversion applications rather than positioning mechanisms, especially taking into account the open-loop control advantage.

  1. Colored ultra-thin hybrid photovoltaics with high quantum efficiency for decorative PV applications (Presentation Recording)

    Science.gov (United States)

    Guo, L. Jay

    2015-10-01

    adopted by other material systems as well. Based on these understandings, we have also developed colored perovskite PV by integrating an optical cavity with the perovskite semiconductors [4]. The principle and experimental results will be presented. 1. J. Y. Lee, K. T. Lee, S.Y. Seo, L. J. Guo, "Decorative power generating panels creating angle insensitive transmissive colors," Sci. Rep. 4, 4192, 2014. 2. K. T. Lee, J.Y. Lee, S.-Y. Seo, and L. J. Guo, "Colored ultra-thin hybrid photovoltaics with high quantum efficiency," Light: Science and Applications, 3, e215, 2014. 3. K. T. Lee, S.-Y. Seo, J.Y. Lee, and L. J. Guo, "Ultrathin metal-semiconductor-metal resonator for angle invariant visible band transmission filters," Appl. Phys. Lett. 104, 231112, (2014); and "Strong resonance effect in a lossy medium-based optical cavity for angle robust spectrum filters," Adv. Mater, 26, 6324-6328, 2014. 4. K. T. Lee, M. Fukuda, L. J. Guo, "Colored, see-through perovskite solar cells employing an optical cavity," Submitted, 2015

  2. Carbon nanotube charge collectors for nanoimprinted hybrid perovskite photovoltaics (Conference Presentation)

    Science.gov (United States)

    Zakhidov, Anvar A.; Haroldson, Ross; Saranin, Danila; Martinez, Patricia; Ishteev, Artur

    2017-06-01

    The hybrid (organo-inorganic) lead-halide perovskites revolutionized the field of solar cell research due to the impressive power conversion efficiencies of up to 21% recently reported in perovskite based solar cells. This talk will present first the general concepts of excitonic photovoltaics, as compared to conventional Si-type solar cells, asking a question: is hybrid perovskite PV an excitonic solar cell or not? Do we need excitons dissociation at D-A interfaces or CNT charge collectors? Then I will show our recent experimental results on the fast spectroscopy of excitons, magnetic field effect on generation of correlated (e-h) pairs. Also will discuss our Hall effect results, that allows to evaluate intrinsic charge carrier transport and direct measurements of mobility in these materials performed for the first time in steady-state dc transport regime. From these measurements, we have obtained the electron-hole recombination coefficient, the carrier diffusion length and lifetime. Our main results include the intrinsic Hall carrier mobility reaching up to 60 cm2V-1s-1 in perovskite single crystals, carrier lifetimes of up to 3 ms (surprisingly too long!), and carrier diffusion lengths as long as 650 μm (huge if compared to organic and even best inorganic materials). Our results also demonstrate that photocarrier recombination in these disordered solution-processed perovskites is as weak as in the best (high-purity single crystals) of conventional direct-band inorganic semiconductors. Moreover, as we show in our experiment, carrier trapping in perovskites is also strongly suppressed, which accounts for such long carrier lifetimes and diffusion lengths, significantly longer than similar parameters in the best inorganic semiconductors, such e.g. as GaAs. All these remarkable transport properties of hybrid perovskites need to be understood from fundamental physics point of view. Looks like we need some new concepts to explain the mysterious properties of

  3. Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice.

    Science.gov (United States)

    Kokolus, Kathleen M; Spangler, Haley M; Povinelli, Benjamin J; Farren, Matthew R; Lee, Kelvin P; Repasky, Elizabeth A

    2014-01-01

    The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especially in laboratory mice since they are used so heavily to model immune responses. The goals of this report are to 1) briefly summarize previous work revealing how DCs respond to various forms of physiological stress and 2) to present new data highlighting the potential for chronic mild cold stress inherent to mice housed at the required standard ambient temperatures to influence baseline DCs properties in naïve and tumor-bearing mice. As recent data from our group shows that CD8(+) T cell function is significantly altered by chronic mild cold stress and since DC function is crucial for CD8(+) T cell activation, we wondered whether housing temperature may also be influencing DC function. Here we report that there are several significant phenotypical and functional differences among DC subsets in naïve and tumor-bearing mice housed at either standard housing temperature or at a thermoneutral ambient temperature, which significantly reduces the extent of cold stress. The new data presented here strongly suggests that, by itself, the housing temperature of mice can affect fundamental properties and functions of DCs. Therefore differences in basal levels of stress due to housing should be taken into consideration when interpreting experiments designed to evaluate the impact of additional variables, including other stressors on DC function.

  4. Quantum dot-based organic-inorganic hybrid materials for optoelectronic applications (Conference Presentation)

    Science.gov (United States)

    Lee, Kwang-Sup

    2016-10-01

    Our recent research involves the design, characterization and testing of devices constituting low bandgap conjugated polymers, surface-engineered quantum dots (QDs), carbon nanotube (CNT)-QDs, QDs decorated nanowires, and QD coupled conjugated polymers. The resulting hybrid materials can be used for facilitating the charge/energy transfer and enhancing the charge carrier mobility in highly efficient optoelectronic and photonic devices. Exploiting the full potential of quantum dots (QDs) in optoelectronic devices require efficient mechanisms for transfer of energy or electrons produced in the optically excited QDs. We propose semiconducting π-conjugated molecules as ligands to achieve energy or charge transfer. The hybridization of p-type π-conjugated molecules to the surface of n-type QDs can induce distinct luminescence and charge transport characteristics due to energy and/or charge transfer effects. QDs and π-conjugated molecule hybrids with controlled luminescent properties can be used for new active materials for light-emitting diodes and flexible displays. In addition, such hybrid systems with enhanced charge transfer efficiency can be used for nanoscale photovoltaic devices. We have also explored single nanoparticle based electronics using QDs and π-conjugated molecule hybrids with molecular-scale n-p or n-insulating (ins)-p-heterojunction structures.

  5. Hybrid nanowire ion-to-electron transducers for integrated bioelectronic circuitry (Conference Presentation)

    Science.gov (United States)

    Carrad, Damon J.; Mostert, Bernard; Meredith, Paul; Micolich, Adam P.

    2016-09-01

    A key task in bioelectronics is the transduction between ionic/protonic signals and electronic signals at high fidelity. This is a considerable challenge since the two carrier types exhibit intrinsically different physics. We present our work on a new class of organic-inorganic transducing interface utilising semiconducting InAs and GaAs nanowires directly gated with a proton transporting hygroscopic polymer consisting of undoped polyethylene oxide (PEO) patterned to nanoscale dimensions by a newly developed electron-beam lithography process [1]. Remarkably, we find our undoped PEO polymer electrolyte gate dielectric [2] gives equivalent electrical performance to the more traditionally used LiClO4-doped PEO [3], with an ionic conductivity three orders of magnitude higher than previously reported for undoped PEO [4]. The observed behaviour is consistent with proton conduction in PEO. We attribute our undoped PEO-based devices' performance to the small external surface and high surface-to-volume ratio of both the nanowire conducting channel and patterned PEO dielectric in our devices, as well as the enhanced hydration afforded by device processing and atmospheric conditions. In addition to studying the basic transducing mechanisms, we also demonstrate high-fidelity ionic to electronic conversion of a.c. signals at frequencies up to 50 Hz. Moreover, by combining complementary n- and p-type transducers we demonstrate functional hybrid ionic-electronic circuits can achieve logic (NOT operation), and with some further engineering of the nanowire contacts, potentially also amplification. Our device structures have significant potential to be scaled towards realising integrated bioelectronic circuitry. [1] D.J. Carrad et al., Nano Letters 14, 94 (2014). [2] D.J. Carrad et al., Manuscript in preparation (2016). [3] S.H. Kim et al., Advanced Materials 25, 1822 (2013). [4] S.K. Fullerton-Shirey et al., Macromolecules 42, 2142 (2009).

  6. Modelling of hybrid scenario: from present-day experiments towards ITER

    Science.gov (United States)

    Litaudon, X.; Voitsekhovitch, I.; Artaud, J. F.; Belo, P.; Bizarro, João P. S.; Casper, T.; Citrin, J.; Fable, E.; Ferreira, J.; Garcia, J.; Garzotti, L.; Giruzzi, G.; Hobirk, J.; Hogeweij, G. M. D.; Imbeaux, F.; Joffrin, E.; Koechl, F.; Liu, F.; Lönnroth, J.; Moreau, D.; Parail, V.; Schneider, M.; Snyder, P. B.; the ASDEX-Upgrade Team; Contributors, JET-EFDA; the EU-ITM ITER Scenario Modelling Group

    2013-07-01

    The ‘hybrid’ scenario is an attractive operating scenario for ITER since it combines long plasma duration with the reliability of the reference H-mode regime. We review the recent European modelling effort carried out within the Integrated Scenario Modelling group which aims at (i) understanding the underlying physics of the hybrid regime in ASDEX-Upgrade and JET and (ii) extrapolating them towards ITER. JET and ASDEX-Upgrade hybrid scenarios performed under different experimental conditions have been simulated in an interpretative and predictive way in order to address the current profile dynamics and its link with core confinement, the relative importance of magnetic shear, s, and E × B flow shear on the core turbulence, pedestal stability and H-L transition. The correlation of the improved confinement with an increased s/q at outer radii observed in JET and ASDEX-Upgrade discharges is consistent with the predictions based on the GLF23 model applied in the simulations of the ion and electron kinetic profiles. Projections to ITER hybrid scenarios have been carried out focusing on optimization of the heating/current drive schemes to reach and ultimately control the desired plasma equilibrium using ITER actuators. Firstly, access condition to the hybrid-like q-profiles during the current ramp-up phase has been investigated. Secondly, from the interpreted role of the s/q ratio, ITER hybrid scenario flat-top performance has been optimized through tailoring the q-profile shape and pedestal conditions. EPED predictions of pedestal pressure and width have been used as constraints in the interpretative modelling while the core heat transport is predicted by GLF23. Finally, model-based approach for real-time control of advanced tokamak scenarios has been applied to ITER hybrid regime for simultaneous magnetic and kinetic profile control.

  7. Hybrid Vehicle Comparison Testing Using Ultracapacitor vs. Battery Energy Storage (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Gonder, J.; Pesaran, A.; Lustbader, J.; Tataria, H.

    2010-02-01

    With support from General Motors, NREL researchers converted and tested a hybrid electric vehicle (HEV) with three energy storage configurations: a nickel metal-hydride battery and two ultracapacitor (Ucap) modules. They found that the HEV equipped with one Ucap module performed as well as or better than the HEV with a stock NiMH battery configuration. Thus, Ucaps could increase the market penetration and fuel savings of HEVs.

  8. Hybrid metal-dielectric nanostructures for advanced light-field manipulation (Conference Presentation)

    Science.gov (United States)

    Staude, Isabelle; Guo, Rui; Rusak, Evgenia; Dominguez, Jason; Decker, Manuel; Rockstuhl, Carsten; Brener, Igal; Neshev, Dragomir N.; Pertsch, Thomas; Kivshar, Yuri S.

    2017-02-01

    All-dielectric and plasmonic nanostructures have complementary advantages regarding their capabilities for controlling light fields at the nanoscale [1]. While all-dielectric nanostructures can provide near-unity efficiency, plasmonic nanostructures are more compact and offer strong near-field enhancement. Combination of photonic nanostructures of both types offers a promising route towards compact optical elements that unify low absorption losses with small footprints, while at the same time providing a high versatility in engineering the optical response of the hybrid system towards specific functionalities. This talk aims to review our recent progress in coupling designed plasmonic nanoantennas to high-index dielectric nanostructures. Following a general analysis of coupling of plasmonic and high-refractive-index dielectric nanoresonators, various specific hybrid nanostructure designs will be discussed. For the fabrication of designed hybrid metal-dielectric nanostructures we use a two-step electron-beam lithography (EBL) procedure [2]. The first step of EBL is used in combination with reactive-ion etching to define the dielectric nanostructures. The second step of EBL is followed by evaporation of gold and a lift-off process, and serves to define the plasmonic elements. Between the two steps, a precision alignment procedure is performed in order to allow for the precise positioning of the gold nanostructures with respect to the silicon nanostructures. Using this approach, we realize and optically characterize various hybrid metal-dielectric nanostructures designed to support a range of novel functionalities, including directional emission enhancement [2] and on-chip light routing. [1] E. Rusak et al., Appl. Phys. Lett. 105, 221109 (2014). [2] R. Guo et al., ACS Photonics 3, 349-353 (2016).

  9. Integrated ion sensor device applications based on printed hybrid material systems (Conference Presentation)

    Science.gov (United States)

    List-Kratochvil, Emil J. W.

    2016-09-01

    Comfortable, wearable sensors and computers will enhance every person's awareness of his or her health condition, environment, chemical pollutants, potential hazards, and information of interest. In agriculture and in the food industry there is a need for a constant control of the condition and needs of plants, animals, and farm products. Yet many of these applications depend upon the development of novel, cheap devices and sensors that are easy to implement and to integrate. Organic semiconductors as well as several inorganic materials and hybrid material systems have proven to combine a number of intriguing optical and electronic properties with simple processing methods. As it will be reviewed in this contribution, these materials are believed to find their application in printed electronic devices allowing for the development of smart disposable devices in food-, health-, and environmental monitoring, diagnostics and control, possibly integrated into arrays of sensor elements for multi-parameter detection. In this contribution we review past and recent achievements in the field. Followed by a brief introduction, we will focus on two topics being on the agenda recently: a) the use of electrolyte-gated organic field-effect transistor (EGOFET) and ion-selective membrane based sensors for in-situ sensing of ions and biological substances and b) the development of hybrid material based resistive switches and their integration into fully functional, printed hybrid crossbar sensor array structures.

  10. Hybrid liquid crystals: Enhanced electro-optic and nonlinear response for manipulating beams (Conference Presentation)

    Science.gov (United States)

    Kaczmarek, Malgosia; D'Alessandro, Giampaolo; Proctor, Matthew B.

    2016-09-01

    The manipulation and processing of light beams can be efficiently accomplished through devices based on soft matter placed in a hybrid "symbiosis" with other organic or inorganic, photoresponsive materials. The performance of such smart modulating systems often relies on a subtle balance between individual properties of each component, together with the varying interaction between organic and inorganic elements. Some promising demonstrations in the visible as well as in the THz regimes include liquid crystals integrated with plasmonic or ferroelectric nanoparticles, photoconductive or photosensitive polymers as well as metamaterials. They offer adaptive, flexible and tailor-made solutions for applications in displays and optoelectronics, switching, steering and modulating electromagnetic waves. Hybrid configurations that include multiple photoresponsive layers, sandwiched with liquid crystals, led to stronger modulation and steering of light beams in the visible. Such effects can also be observed in the other regions of spectrum, as inorganic nanoparticles dispersed in liquid crystals modify the magnitude of the material refractive indices measured in THz. The development of such hybrid materials has to be accompanied by comprehensive characterisation of their uniformity, stability and optical quality across the whole surface of the device, capable of determining their optical, electrical and physical parameters.

  11. Interface engineering in inorganic hybrid structures towards improved photocatalysis (Conference Presentation)

    Science.gov (United States)

    Xiong, Yujie

    2016-10-01

    Designing new photocatalytic materials for improving photoconversion efficiency is a promising route to alleviate the steadily worsening environmental issues and energy crisis. Despite the invention of a large number of catalytic materials with well-defined structures, their overall efficiency in photocatalysis is still quite limited as the three key steps - light harvesting, charge generation and separation, and charge transfer to surface for redox reactions - have not been substantially improved. To improve each step in the complex process, there is a major trend to develop materials based on inorganic hybrid structures. In this case, interface engineering holds the promise for boosting the overall efficiency, given the key roles of interface structures in charge and energy transfer. In this talk, I will demonstrate several different approaches to designing inorganic hybrid structures with improved photocatalytic performance via interface engineering. The typical demonstrations include semiconductor-plasmonics systems for broad-spectrum light harvesting, metal-semiconductor interfaces for improved charge separation, semiconductor-MOF (metal-organic framework) configurations for activated surface reactions. It is anticipated that this series of works open a new window to rationally designing inorganic hybrid materials for photo-induced applications. References: (1) Bai, S.; Yang, L.; Wang, C.; Lin, Y.; Lu, J.; Jiang, J. and Xiong, Y.*, Angew. Chem. Int. Ed. 54, 14810-14814 (2015). (2) Bai, S.; Jiang, J.; Zhang, Q. and Xiong, Y.*, Chem. Soc. Rev. 44, 2893-2939 (2015). (3) Bai, S.; Li, X.; Kong, Q.; Long, R.; Wang, C.; Jiang, J. and Xiong, Y.*, Adv. Mater. 27, 3444-3452 (2015). (4) Bai, S.; Ge, J.; Wang, L.; Gong, M.; Deng, M.; Kong, Q.; Song, L.; Jiang, J.;* Zhang, Q.;* Luo, Y.; Xie, Y. and Xiong, Y.*, Adv. Mater. 26, 5689-5695 (2014). (5) Li, R.; Hu, J.; Deng, M.; Wang, H.; Wang, X.; Hu, Y.; Jiang, H. L.; Jiang, J.;* Zhang, Q.;* Xie, Y. and Xiong, Y.*, Adv. Mater

  12. Transcap: A new integrated hybrid supercapacitor and electrolyte-gated transistor device (Presentation Recording)

    Science.gov (United States)

    Santato, Clara

    2015-10-01

    The boom in multifunctional, flexible, and portable electronics and the increasing need of low-energy cost and autonomy for applications ranging from wireless sensor networks for smart environments to biomedical applications are triggering research efforts towards the development of self-powered sustainable electronic devices. Within this context, the coupling of electronic devices (e.g. sensors, transistors) with small size energy storage systems (e.g. micro-batteries or micro-supercapacitors) is actively pursued. Micro-electrochemical supercapacitors are attracting much attention in electronics for their capability of delivering short power pulses with high stability over repeated charge/discharge cycling. For their high specific pseudocapacitance, electronically conducting polymers are well known as positive materials for hybrid supercapacitors featuring high surface carbon negative electrodes. The processability of both polymer and carbon is of great relevance for the development of flexible miniaturised devices. Electronically conducting polymers are even well known to feature an electronic conductivity that depends on their oxidation (p-doped state) and that it is modulated by the polymer potential. This property and the related pseudocapacitive response make polymer very attracting channel materials for electrolyte-gated (EG) transistors. Here, we propose a novel concept of "Trans-capacitor", an integrated device that exhibits the storage properties of a polymer/carbon hybrid supercapacitor and the low-voltage operation of an electrolyte-gated transistor.

  13. The coming of age of the first hybrid metrology software platform dedicated to nanotechnologies (Conference Presentation)

    Science.gov (United States)

    Foucher, Johann; Labrosse, Aurelien; Dervillé, Alexandre; Zimmermann, Yann; Bernard, Guilhem; Martinez, Sergio; Grönqvist, Hanna; Baderot, Julien; Pinzan, Florian

    2017-03-01

    The development and integration of new materials and structures at the nanoscale require multiple parallel characterizations in order to control mostly physico-chemical properties as a function of applications. Among all properties, we can list physical properties such as: size, shape, specific surface area, aspect ratio, agglomeration/aggregation state, size distribution, surface morphology/topography, structure (including crystallinity and defect structure), solubility and chemical properties such as: structural formula/molecular structure, composition (including degree of purity, known impurities or additives), phase identity, surface chemistry (composition, charge, tension, reactive sites, physical structure, photocatalytic properties, zeta potential), hydrophilicity/lipophilicity. Depending on the final material formulation (aerosol, powder, nanostructuration…) and the industrial application (semiconductor, cosmetics, chemistry, automotive…), a fleet of complementary characterization equipments must be used in synergy for accurate process tuning and high production yield. The synergy between equipment so-called hybrid metrology consists in using the strength of each technique in order to reduce the global uncertainty for better and faster process control. The only way to succeed doing this exercise is to use data fusion methodology. In this paper, we will introduce the work that has been done to create the first generic hybrid metrology software platform dedicated to nanotechnologies process control. The first part will be dedicated to process flow modeling that is related to a fleet of metrology tools. The second part will introduce the concept of entity model which describes the various parameters that have to be extracted. The entity model is fed with data analysis as a function of the application (automatic analysis or semi-automated analysis). The final part will introduce two ways of doing data fusion on real data coming from imaging (SEM, TEM, AFM

  14. Lower hybrid heating and current drive design for ITER and application for present tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Froissard, P.; Rey, G.; Bibet, P.; Goniche, M.; Kazarian, F.; Portafaix, C.; Tonon, G. [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Bosia, G.; Bruno, L. [ITER Joint Work Site, Garching (Germany); Kuzikov, S. [Inst. of Applied Physics, Nizhny Novgorod (Russian Federation); Wasastjerna, F. [VTT Energy (Finland)

    1998-07-01

    The lower Hybrid Heating and Current Drive (LHH and CD) System shall provide on ITER off-axis current profile control during burn, main contribution to the non-inductive current generation in the advanced Tokamak scenario, current profile tailoring during ramp up phase, heating and current drive during plasma shut-down, extension of the pulse duration during commissioning phase. The LHH and CD system operates at 5 GHz, this frequency being a trade-off between power absorption by alpha particles and klystron technology and couples a minimum of 50 MW using two ITER ports. This article describes the launcher plug and the transmission lines. Specific converters, such as the mode converters, RF windows and the hyper-guide have now been successfully tested at high power and long pulse duration.

  15. Controlling light emission performance with hybrid phase-change plasmonic crystals (Conference Presentation)

    Science.gov (United States)

    Kao, Tsung Sheng

    2016-09-01

    In this paper, we demonstrate a novel approach in which the lattice resonances are tunable in a hybrid plasmonic crystal incorporating the phase-change material Ge2Sb2Te5 (GST) as a 20-nm-thick layer sandwiched between a gold nanodisk array and a quartz substrate. Non-volatile tuning of lattice resonances over a range Δλ of about 500 nm is achieved experimentally via intermediate phase states of the GST layer. This work demonstrates the efficacy and ease of resonance tuning via GST in the near infrared, suggesting the possibility to design broadband non-volatile tunable devices for optical modulation, switching, sensing and nonlinear optical devices. Also, with different nanostructure designs, the constituent plasmonic resonators can be selectively excited, generating isolated near-field energy hot-spots with selective excitation under a monochromatic plane wave illumination. Unlike other proposed techniques, our method for energy hot-spot positioning is based on a quantitative control of the crystalline proportions of the phase-change thin film rather than the complicated manipulations of an incident light beam. This makes such a near-field energy controllable template much easier to be implemented. This near-field energy controllable system consists of gold nano-antennas with deep subwavelength spacing and an underlying GST thin layer. Such a hybrid plasmonic system is easy to be implemented and the nanoscale energy hot-spot can be positioned in a large field of view by extending the system with different plasmon resonators, suggesting a further step toward applications such as nano-imaging, bio-assay addressing and nano-circuitry.

  16. A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-chain acyl-CoA dehydrogenase-deficient patients with mild childhood presentation

    DEFF Research Database (Denmark)

    Bross, P; Pedersen, P; Nyholm, M;

    1999-01-01

    The consequences of two amino acid polymorphisms of human electron transfer flavoprotein (alpha-T/I171 in the alpha-subunit and beta-M/T154 in the beta-subunit) on the thermal stability of the enzyme are described. The alpha-T171 variant displayed a significantly decreased thermal stability...... thermal stability) was significantly overrepresented. Subgrouping of the VLCAD patients into three phenotypic classes (severe childhood, mild childhood, and adult presentation) revealed that the overrepresentation of the alpha-T171 variant was significant only in patients with mild childhood presentation...

  17. EPA Presentation Regarding the Advanced Light-Duty Powertrain and Hybrid Analysis (ALPHA) Tool

    Science.gov (United States)

    This page contains a selection of the presentations that EPA has publicly presented about our work on the Midterm Evaluation (MTE). It highlights EPA's benchmarking and modeling activities relating to light duty greenhouse gas (GHG) emissions.

  18. Hybrid metal-organic conductive network with plasmonic nanoparticles and fluorene (Conference Presentation)

    Science.gov (United States)

    Fontana, Laura; Fratoddi, Ilaria; Matassa, Roberto; Familiari, Giuseppe; Venditti, Iole; Batocchio, Chiara; Magnano, Elena; Nappini, Silvia; Leahu, Grigore; Belardini, Alessandro; Li Voti, Roberto; Sibilia, Concita

    2017-05-01

    For the development of new generation portable electronic devices, the realization of thin and flexible electrodes have a crucial role. Conductive organic systems can address this issue in different ways. Indeed, conductance in organic molecules were studied in different papers starting from seminal papers in last 70's [1] up to recent ones [2]. Among organic species, conduction and electronic characteristics of Fluorene derivatives were studied in different configurations [3,4]. Unfortunately, the conductance of organic materials is limited by charge transport mechanism [5]. Hybrid system with organic conductive compounds covalently linked with metal centres can lead to enhanced conductivity [6]. Here we synthesized gold and silver nanoparticles (AuNPs and AgNPs) stabilized with a fluorene thiolate derivative, namely 9,9-Didodecyl-2,7-bis(acetylthio)fluorene (FL). In the synthesis process the metal nanoparticles (MNPs) size results to be around 5 nm in diameter [7]. When deposited on a planar substrate, the hybrid compound form a regular network of MNPs separated each other by fluorene spacers covalently linked by thiol groups [8]. We deposited the network on substrate with two interdigitated electrodes in order to measure conductive properties (I-V characteristics). In I-V measurements it results to be that AgNPs based network is 200 times more conductive than AuNPs one. Selective oxidation of AgNPs network close to positive electrodes gives rise to a Schottky diode behavior in the I-V characteristic that could find potential applications in nano-electronics devices. The fluorescence and extinction spectra of FL-AgNPs and FL-AuNPs where characterised. References [1] C. K. Chiang, C. R. Fincher, Jr., Y. W. Park, A. J. Heeger, H. Shirakawa, E. J. Louis, S. C. Gau, and Alan G. MacDiarmid, Phys. Rev. Lett. 39, 1098 (1977). [2] Hylke B. Akkerman, Paul W. M. Blom, Dago M. de Leeuw and Bert de Boer, Nature 441, 69 (2006). [3] Rajendra Prasad Kalakodimi, Aletha M. Nowak

  19. Charge-carrier dynamics in hybrid metal halide perovskites (Conference Presentation)

    Science.gov (United States)

    Milot, Rebecca L.; Rehman, Waqaas; Eperon, Giles E.; Snaith, Henry J.; Johnston, Michael B.; Herz, Laura M.

    2016-09-01

    Hybrid metal halide perovskites are attractive components for many optoelectronic applications due to a combination of their superior charge transport properties and relative ease of fabrication. A complete understanding of the nature of charge transport in these materials is therefore essential for current and future device development. We have evaluated two systems - the standard perovskite methylammonium lead triiodide (CH3NH3PbI3) and a series of mixed-iodide/bromide formamidinium lead perovskites - in an effort to determine what effect structural and chemical composition have on optoelectronic properties including mobility, charge-carrier recombination dynamics, and charge-carrier diffusion length. The photoconductivity in thin films of CH3NH3PbI3was investigated from 8 K to 370 K across three structural phases [1]. While the monomolecular charge-carrier recombination rate was found to increase with rising temperature indicating a mechanism dominated by ionized impurity mediated recombination, the bimolecular rate constant decreased with rising temperature as charge-carrier mobility declined. The Auger rate constant was highly phase specific, suggesting a strong dependence on electronic band structure. For the mixed-halide formamidinuim lead bromide-iodide perovskites, HC(NH2)2Pb(BryI1-y)3, bimolecular and Auger charge-carrier recombination rate constants strongly correlated with bromide content, which indicated a link with electronic structure [2]. Although HC(NH2)2PbBr3 and HC(NH2)2PbI3 exhibited high charge-carrier mobilities and diffusion lengths exceeding 1 μm, mobilities for mixed Br/I perovskites were all lower as a result of crystalline phase disorder.

  20. Presentation

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Freire Vieira

    2013-12-01

    Full Text Available This dossier focuses on one of the essential debate topics today about the territorial dimension of the new development strategies concerned with the worsening of the global socioecological crisis, that is: the challenges related to the activation and integration in networks of localized agri-food systems. For its composition, some contributions presented and debated during the VI International Conference on Localized Agri-food System - The LAFS facing the opportunities and challenges of the new global context have been gathered. The event took place in the city of Florianópolis, from May 21th to 25th of 2013. The event was promoted by the Federal University of Santa Catarina (UFSC and by the Center for the International Cooperation on Agricultural Research for Development (CIRAD. Besides UFSC and CIRAD, EPAGRI, State University of Santa Catarina (UDESC, as well as research institutes and universities from other states (UFMG, IEA/SP, UFS, UFRGS and Mexican and Argentinian partners from the RED SIAL Latino Americana also participated in the organization of lectures, discussion tables and workshops.

  1. Presentation

    Directory of Open Access Journals (Sweden)

    Eduardo Vicente

    2013-06-01

    Full Text Available In the present edition of Significação – Scientific Journal for Audiovisual Culture and in the others to follow something new is brought: the presence of thematic dossiers which are to be organized by invited scholars. The appointed subject for the very first one of them was Radio and the invited scholar, Eduardo Vicente, professor at the Graduate Course in Audiovisual and at the Postgraduate Program in Audiovisual Media and Processes of the School of Communication and Arts of the University of São Paulo (ECA-USP. Entitled Radio Beyond Borders the dossier gathers six articles and the intention of reuniting works on the perspectives of usage of such media as much as on the new possibilities of aesthetical experimenting being build up for it, especially considering the new digital technologies and technological convergences. It also intends to present works with original theoretical approach and original reflections able to reset the way we look at what is today already a centennial media. Having broadened the meaning of “beyond borders”, four foreign authors were invited to join the dossier. This is the first time they are being published in this country and so, in all cases, the articles where either written or translated into Portuguese.The dossier begins with “Radio is dead…Long live to the sound”, which is the transcription of a thought provoking lecture given by Armand Balsebre (Autonomous University of Barcelona – one of the most influential authors in the world on the Radio study field. It addresses the challenges such media is to face so that it can become “a new sound media, in the context of a new soundscape or sound-sphere, for the new listeners”. Andrew Dubber (Birmingham City University regarding the challenges posed by a Digital Era argues for a theoretical approach in radio studies which can consider a Media Ecology. The author understands the form and discourse of radio as a negotiation of affordances and

  2. Presentation

    Directory of Open Access Journals (Sweden)

    Helmut Renders

    2008-10-01

    Full Text Available We present to our esteemed readers the second edition of our journal for 2008. We have chosen the theme “The life and work of Prof. Dr. Jürgen Moltmann” as its special emphasis. It is our way to pay homage to J. Moltmann in the year the Universidade Metodista de São Paulo awards him an honorary Doctor Honoris Causa degree. Sincethe seventies, Moltmann and Latin America have been in dialog. In his emblematic work “A Theology of Liberation”, Gustavo Gutiérrez, the Catholic, discussed with Moltmann, the Reformed, the relationship between eschatology and history (GUTIÉRREZ, Gustavo.Teologia da Libertação. 5ª edição. Petrópolis, RJ: Vozes, 1985, p. 27, 137-139. A dialog held in the premises of IMS, which nowadays is called UMESP, has produced the little book “Passion for life” (MOLTMANN, Jürgen. Paixão pela vida. São Paulo, SP: ASTE - Associaçãode Seminários Teológicos Evangélicos, 1978.In the following years, the wide theological work of J. Moltmann went all the way from debates to congresses and has conquered the classrooms. Most probably, J. Moltmann is nowadays the most widely read European author in Brazilian theological seminaries. Thisrecognition can only be held in unison and the wide response to our request for articles confirms the huge repercussion that Moltmann’s work has been having up to today in Brazil. The ecumenical theologian J. Moltmann is ecumenically read. We believe that thisway we may be better equipped to answer to anyone who asks us for the reason there is hope in us. We have organized the articles on J. Moltmann’s theology according to the original publication date of the books dealt with in each essay. We also communicate that some articles which were originally requested for this edition of the journal will be published in the journal Estudos de Regilião in May 2009.As it is usual with the journal Caminhando, we have, besides this thematic emphasis, yet other contributions in the areas of

  3. Presentation

    Directory of Open Access Journals (Sweden)

    Nicanor Lopes

    2010-11-01

    Full Text Available The Journal Caminhando debuts with a new editorial format: eachmagazine will have a Dossier.In 2010 Christianity celebrated the centenary of Edinburgh. TheWorld Missionary Conference in Edinburgh in 1910 is regarded by manyas missiological watershed in the missionary and ecumenical movement.So the Faculty of Theology of the Methodist Church (FATEO decidedto organize a Wesleyan Week discussing the issue of mission. For anevent of this magnitude FATEO invited the Rev. Dr. Wesley Ariarajah,Methodist pastor and teacher of Sri Lanka with extensive experience inpastoral ministry in local churches and professor of History of Religionsand the New Testament at the Theological College of Lanka, maintainedby the Protestant Churches in Sri Lanka. In 1981 he was invited to jointhe World Council of Churches, where he presided for over ten years theCouncil of Interreligious Dialogue. From 1992 he served as Deputy GeneralSecretary of the WCC.The following texts are not the speeches of the Rev. Dr. WesleyAriarajah, for they will be published separately. Nevertheless, the journaldialogs with the celebrations of the centenary of Edinburgh, parting formthe intriguing theme: "Mission in the 21st century in Brazil". After all, howis it that mission takes place among us in personal, church, and communityactivities?Within the Dossier, as common to the journal, the textos are organizedas follows: Bible, Theology / History and Pastoral Care. Other items thatdo not fit within the Dossier, but, do articulate mission, can be found inthe section Declarations and Documents and Book Reviews.The authors of the Dossier have important considerations in buildinga contemporary missiological concept considering Brazilian reality.Anderson de Oliveira, in the Bible-Section, presents a significantexegeses of Matthew 26.6-13. What does it mean when Jesus is quotedwith the words: "For the poor always ye have with you, but me ye havenot always." Is this declaration challenging the gospels

  4. An adaptive metamaterial beam with hybrid shunting circuits for extremely broadband control of flexural wave (Conference Presentation)

    Science.gov (United States)

    Chen, Yangyang; Huang, Guoliang

    2017-04-01

    A great deal of research has been devoted to controlling the dynamic behaviors of phononic crystals and metamaterials by directly tuning the frequency regions and/or widths of their inherent band gaps. Here, we present a novel approach to achieve extremely broadband flexural wave/vibration attenuation based on tunable local resonators made of piezoelectric stacks shunted by hybrid negative capacitance and negative inductance circuits with proof masses attached on a host beam. First, wave dispersion relations of the adaptive metamaterial beam are calculated analytically by using the transfer matrix method. The unique modulus tuning properties induced by the hybrid shunting circuits are then characterized conceptually, from which the frequency dependent modulus tuning curves of the piezoelectric stack located within wave attenuation frequency regions are quantitatively identified. As an example, a flexural wave high-pass band filter with a wave attenuation region from 0 to 23.0 kHz is demonstrated analytically and numerically by using the hybrid shunting circuit, in which the two electric components are connected in series. By changing the connection pattern to be parallel, another super wide wave attenuation region from 13.5 to 73.0 kHz is demonstrated to function as a low-pass filter at a subwavelength scale. The proposed adaptive metamaterial possesses a super wide band gap created both naturally and artificially. Therefore, it can be used for the transient wave mitigation at extremely broadband frequencies such as blast or impact loadings. We envision that the proposed design and approach can open many possibilities in broadband vibration and wave control.

  5. Travelling in time with networks: Revealing present day hybridization versus ancestral polymorphism between two species of brown algae, Fucus vesiculosus and F. spiralis

    Directory of Open Access Journals (Sweden)

    Pearson Gareth A

    2011-01-01

    Full Text Available Abstract Background Hybridization or divergence between sympatric sister species provides a natural laboratory to study speciation processes. The shared polymorphism in sister species may either be ancestral or derive from hybridization, and the accuracy of analytic methods used thus far to derive convincing evidence for the occurrence of present day hybridization is largely debated. Results Here we propose the application of network analysis to test for the occurrence of present day hybridization between the two species of brown algae Fucus spiralis and F. vesiculosus. Individual-centered networks were analyzed on the basis of microsatellite genotypes from North Africa to the Pacific American coast, through the North Atlantic. Two genetic distances integrating different time steps were used, the Rozenfeld (RD; based on alleles divergence and the Shared Allele (SAD; based on alleles identity distances. A diagnostic level of genotype divergence and clustering of individuals from each species was obtained through RD while screening for exchanges through putative hybridization was facilitated using SAD. Intermediate individuals linking both clusters on the RD network were those sampled at the limits of the sympatric zone in Northwest Iberia. Conclusion These results suggesting rare hybridization were confirmed by simulation of hybrids and F2 with directed backcrosses. Comparison with the Bayesian method STRUCTURE confirmed the usefulness of both approaches and emphasized the reliability of network analysis to unravel and study hybridization

  6. Travelling in time with networks: Revealing present day hybridization versus ancestral polymorphism between two species of brown algae, Fucus vesiculosus and F. spiralis.

    Science.gov (United States)

    Moalic, Yann; Arnaud-Haond, Sophie; Perrin, Cécile; Pearson, Gareth A; Serrao, Ester A

    2011-01-31

    Hybridization or divergence between sympatric sister species provides a natural laboratory to study speciation processes. The shared polymorphism in sister species may either be ancestral or derive from hybridization, and the accuracy of analytic methods used thus far to derive convincing evidence for the occurrence of present day hybridization is largely debated. Here we propose the application of network analysis to test for the occurrence of present day hybridization between the two species of brown algae Fucus spiralis and F. vesiculosus. Individual-centered networks were analyzed on the basis of microsatellite genotypes from North Africa to the Pacific American coast, through the North Atlantic. Two genetic distances integrating different time steps were used, the Rozenfeld (RD; based on alleles divergence) and the Shared Allele (SAD; based on alleles identity) distances. A diagnostic level of genotype divergence and clustering of individuals from each species was obtained through RD while screening for exchanges through putative hybridization was facilitated using SAD. Intermediate individuals linking both clusters on the RD network were those sampled at the limits of the sympatric zone in Northwest Iberia. These results suggesting rare hybridization were confirmed by simulation of hybrids and F2 with directed backcrosses. Comparison with the Bayesian method STRUCTURE confirmed the usefulness of both approaches and emphasized the reliability of network analysis to unravel and study hybridization.

  7. The development of seed-propagated peach-almond hybrids for use as almond rootstocks (Oral presentation)

    Science.gov (United States)

    Peach-almond hybrids are becoming increasingly popular rootstocks in California almond orchards due to their enhanced vigor as compared with almond propagated on peach root. However, these hybrids are difficult to root without the use of in vitro micropropagation. The development of uniform and vi...

  8. Mild Intellectual Disability Associated with a Progeny of Father-Daughter Incest: Genetic and Environmental Considerations

    Science.gov (United States)

    Ansermet, Francois; Lespinasse, James; Gimelli, Stefania; Bena, Frederique; Paoloni-Giacobino, Ariane

    2010-01-01

    We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the…

  9. Development of a hybrid broadband NIRS/diffusion correlation spectroscopy system to monitor preterm brain injury (Conference Presentation)

    Science.gov (United States)

    Rajaram, Ajay; St. Lawrence, Keith; Diop, Mamadou

    2017-02-01

    In Canada, 8% of births occur prematurely. Preterm infants weighing less than 1500g are at a high risk of neurodevelopmental impairment: 5-10% develop major disabilities such as cerebral palsy and 40-50% show other cognitive and behavioural deficits. The brain is vulnerable to periods of low cerebral blood flow (CBF) that can impair energy metabolism and cause tissue damage. There is, therefore, a need for an efficient neuromonitoring system to alert the neonatal intensive care team to clinically significant changes in CBF and metabolism, before injury occurs. Optical technologies offer safe, non-invasive, and cost-effective methods for neuromonitoring. Cerebral oxygen saturation (ScO2) can be measured by exploiting the absorption properties of hemoglobin though Near-Infrared Spectroscopy (NIRS), and Diffuse Correlation Spectroscopy (DCS) can monitor CBF by tracking red blood cells. These measures can be combined to describe metabolism, a key indicator of tissue viability. In this study we present the development and testing of a hybrid broadband NIRS/DCS neuromonitor. This system is novel in its ability to simultaneously acquire broadband NIRS and DCS signals, providing a truly real-time measure of metabolism. Narrow bandpass and notch filters have been incorporated to diminish light contamination between the two modalities, preferentially filtering out each source from the opposing detector, allowing for an accurate measure of ScO2, CBF, and metabolism. With a broadband NIRS/DCS system, a real-time measure of CBF and metabolism within the developing brain can aid clinicians in monitoring events that precede brain injury, ultimately leading to better clinical outcomes.

  10. Betwixt and Between Past and Present: Cultural and Generic Hybridity in the Fiction of Amy Tan and Mary Yukari Waters

    Directory of Open Access Journals (Sweden)

    Rania Youssef

    2013-10-01

    Full Text Available Amy Tan and Mary Yukari Waters are both Asian-Americans who portray hybridity in their short stories which depict the shifting identities of the self. But do the internal categories of gender, race and ethnicity help in the coherence or do they add to the fragmentation of diverse identities? It is the dynamics of this critique of multiple identification and hybrid cultures that is being traced here in this study and how all this is reflected in narrative responses to such conditions of the examination of the self and, on a broader scale, community. The study builds on Victor Turner’s theory of liminality. Key words Hybridity, liminality, multiple identity, race, culture.

  11. Quantification by HPLC-MS/MS of atropine in human serum and clinical presentation of six mild-to-moderate intoxicated atropine-adulterated-cocaine users

    NARCIS (Netherlands)

    Boermans, PAMM; Go, HS; Wessels, AMA; Uges, DRA

    2006-01-01

    An unexpectedly high number of initially suspected cocaine-intoxicated patients was presented to a general hospital in Lelystad, The Netherlands. Based on the unusual toxidram rate of not fitting cocaine intoxication, the suspicion of co-presence of an anticholinergic agent was raised. A newly devel

  12. 超轻度混合动力汽车动力转换控制策略%Control strategy on power conversion of the super-mild hybrid electric vehicle

    Institute of Scientific and Technical Information of China (English)

    张伯俊; 郭家田

    2011-01-01

    The control strategy on power conversion that the engine keeps on working along the optimal economy curve or the motor running in a higher efficiency is elaborated in this paper. With the throttle position and the battery's SOC state to determine the working state of the two power source, the power conversion fuzzy control of the super-mild hybrid electric vehicles is designed. And the overall vehicle control and simulation model is built. In the end the control of engine starting, speed regulation is discussed, which makes the quick and smooth clutch combination.%讨论以发动机最佳燃油经济性或电动机最佳效率为控制目标的动力转换控制策略,以油门踏板位置及蓄电池SOC状态为输入变量,设计了混合动力汽车动力转换模糊控制器,建立了整车控制仿真模型。文中阐述了由电机切换到发动机工作时发动机的起动、调速控制,以及离合器快速平稳地结合的过程。仿真结果表明:对转换车速的门限值控制模糊化能够使转换车速更加符合驾驶员对动力性的要求。

  13. Testing Low-Energy, High-Power Energy Storage Alternatives in a Full-Hybrid Vehicle (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Cosgrove, J.; Gonger, J.

    2014-01-01

    Automakers have been mass producing hybrid electric vehicles (HEVs) for well over a decade, and the technology has proven to be very effective at reducing per-vehicle gasoline use. However, the battery cost in HEVs contribute to higher incremental cost of HEVs (a few thousand dollars) than the cost of comparable conventional vehicles, which has limited HEV market penetration. Significant cost reductions/performance improvements to the energy storage system (ESS) can improve the vehicle-level cost vs. benefit relationship for HEVs. Such an improvement could lead to larger HEV market penetration and greater aggregate gasoline savings. After significant analysis by the National Renewable Energy Laboratory (NREL), the United States Advanced Battery Consortium (USABC) and Department of Energy (DOE) Energy Storage program suggested a new set of requirements for ESS for power-assist HEVs for cost reduction without impacting performance and fuel economy significantly. With support from DOE, NREL has developed an HEV test platform for in-vehicle performance and fuel economy validation testing of the hybrid system using such LEESS devices. This poster will describe development of the LEESS HEV test platform, and LEESS laboratory as well as in-vehicle evaluation results. The first LEESS technology tested was lithium-ion capacitors (LICs) - i.e., asymmetric electrochemical energy storage devices possessing one electrode with battery-type characteristics (lithiated graphite) and one with ultracapacitor-type characteristics (carbon). We will discuss the performance and fuel saving results with LIC with comparison with original NiMH battery.

  14. Applying support vector machine on hybrid fNIRS/EEG signal to classify driver's conditions (Conference Presentation)

    Science.gov (United States)

    Nguyen, Thien; Ahn, Sangtae; Jang, Hyojung; Jun, Sung C.; Kim, Jae G.

    2016-03-01

    Driver's condition plays a critical role in driving safety. The fact that about 20 percent of automobile accidents occurred due to driver fatigue leads to a demand for developing a method to monitor driver's status. In this study, we acquired brain signals such as oxy- and deoxyhemoglobin and neuronal electrical activity by a hybrid fNIRS/EEG system. Experiments were conducted with 11 subjects under two conditions: Normal condition, when subjects had enough sleep, and sleep deprivation condition, when subject did not sleep previous night. During experiment, subject performed a driving task with a car simulation system for 30 minutes. After experiment, oxy-hemoglobin and deoxy-hemoglobin changes were derived from fNIRS data, while beta and alpha band relative power were calculated from EEG data. Decrement of oxy-hemoglobin, beta band power, and increment of alpha band power were found in sleep deprivation condition compare to normal condition. These features were then applied to classify two conditions by Fisher's linear discriminant analysis (FLDA). The ratio of alpha-beta relative power showed classification accuracy with a range between 62% and 99% depending on a subject. However, utilization of both EEG and fNIRS features increased accuracy in the range between 68% and 100%. The highest increase of accuracy is from 63% using EEG to 99% using both EEG and fNIRS features. In conclusion, the enhancement of classification accuracy is shown by adding a feature from fNIRS to the feature from EEG using FLDA which provides the need of developing a hybrid fNIRS/EEG system.

  15. Développement d'un système de gestion de batterie lithium-ion à destination de véhicules "mild hybrid" : détermination des indicateurs d'état (SoC, SoH et SoF)

    OpenAIRE

    LIEVRE, Aurélien

    2015-01-01

    Les véhicules hybrides se démocratisent avec une utilisation croissante des éléments de stockage à base de lithium-ion. Dans ce contexte d'exploitation, le type d'usage est atypique et dépend fortement des stratégies de répartition des énergies au sein du véhicule. Parmi les hybridations, la catégorie "mild hybrid" conserve la motorisation thermique pour l'autonomie qu'elle apporte, et lui adjoint une machine électrique associée à un élément de stockage réversible, afin de permettre une récup...

  16. On-demand rapid transport and stable trapping of nanoparticles of nanoparticles by a hybrid electrothermoplasmonic nanotweezer (Conference Presentation)

    Science.gov (United States)

    Ndukaife, Justus C.; Nnanna, Agbai George Agwu; Kildishev, Alexander V.; Shalaev, Vladimir M.; Wereley, Steven T.; Boltasseva, Alexandra

    2016-09-01

    In plasmon nano-optical tweezers, plasmonic nanoantennas are illuminated to generate highly localized and enhanced electromagnetic field in the vicinity of the nanoantenna. The highly localized and enhanced electromagnetic field creates much stronger optical gradient forces and tighter potential wells for confining particles than in conventional optical tweezers, thus providing a means to trap nanoscale objects and molecules. This approach have been successfully applied for trapping small particles such as protein molecules. However a long standing problem in this field is how to rapidly load the potential well without relying on Brownian diffusion. Conventional design rely on Brownian diffusion to load the trap, which is very slow and could take several minutes to hours depending on the concentration of the nanoscale objects. Furthermore since the plasmonic trapping sites are pre-patterned on a substrate, current plasmonic nanotweezers suffer from the problem of lack of dynamic control over the particles in the trap. Recently we have addressed these challenges by introducing a novel design paradigm known as the Hybrid Electrothermoplasmonic Nanotweezer (HENT)1, where the intrinsic photo-induced heating of the plasmonic nanoantenna is combined with an applied AC electric field to induce a large scale microfluidic flow on-demand. The microfluidic flow enables rapid delivery of suspended nanoparticles to an illuminated plasmonic nanoantenna where they are trapped within a few seconds. In this talk I will discuss the working principle of HENT, as well as HENT-based nanotweezers utilizing alternative plasmonic materials.

  17. Evaluation of Eleven Macro and Micro Elements Present in Various Hybrids of Millet (Pennisetum glaucum, or P. Americanum

    Directory of Open Access Journals (Sweden)

    Ghulam Qadir Shar

    2012-06-01

    Full Text Available Maize and Millet Research Institute (MMRI situated in Yousuf wala, District Sahiwal, Punjab, Pakistan was selected to grow nine different hybrids/cultivars of millet for study to comprehend the variable concentration of macro, micro and trace and toxic elements in their grains. Wet digestion method was used for the preparation of samples and flame atomic absorption spectrophotometer for analysis of eleven major and minor elements. High values of macro-elements i.e. sodium and potassium was found in ICMP-451 and magnesium in ICMP-53506. The high value of essential micro-elements i.e.zinc (50mg/kg, manganese (8mg/kg, and copper (8mg/kg was calculated in ICMP-53506, Bullo-94-1, and ICMP-83720 respectively. In case of trace and toxic micro-elements, high concentration of nickel, cobalt, chromium and cadmium was found in O.B.V, Bullo-7704, ICMP-83401, and ICMP-83720 in the edible part of millet plants (grains cultivars respectively.

  18. Inorganic–organic hybrids presenting high basic center content: SBA-15 incorporation, toxic metals sorption and energetic behavior

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Fernando J.V.E. [Departamento de Química, Universidade Federal da Paraíba, 58059-900 João Pessoa, PB (Brazil); Melo, Maurício A. [Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, São Paulo (Brazil); Airoldi, Claudio, E-mail: airoldi@iqm.unicamp.br [Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, São Paulo (Brazil)

    2013-03-15

    Highlights: ► Mesoporous SBA-15 silicas were organofunctionalized with new silylant agents. ► Thiocarbamate was used to enhance the silylating agent chains and basic centers. ► The synthesized pendant chains contain nitrogen and sulfur basic centers. ► The new hybrids sorb toxic cations from aqueous solutions with high efficiency. ► The thermodynamic data demonstrated favorable cation/basic center interactions. - Abstract: Mesoporous SBA-15 samples were organofunctionalized with mono, di- and tri-aminosilanes that previously reacted with thiocarbamide to enhance the organic chains and attach nitrogen and sulfur basic centers to the surface of the solids. These new organosilanes were synthesized through a non-solvent approach to reduce both cost and hazardous wastes. The high affinities for both hard and soft Lewis acids due to the combination of nitrogen and sulfur atoms attached to the same pendant chain enabled favorable sorption capacities for Cu{sup 2+}, Cd{sup 2+} and Pb{sup 2+} cations, with maximum capacities of 1.90, 3.48 and 5.30 mmol g{sup −1}, respectively, for the most efficient mesoporous silica. Microcalorimetric investigations allowed the calculation of the thermodynamic data at the solid/liquid interface. All Gibbs energy are negative as expected for spontaneous cation/basic center interactions and the positive entropic values from 49 ± 3 to 108 ± 5 J K{sup −1} mol{sup −1}, also reinforced this favorable interactive process in heterogeneous system. The designed organosilanes covalently bonded to the inorganic siliceous skeleton can be suggested as new materials for toxic metal removal from a wastewater with high efficiency.

  19. Development of a Generalized Version of the Poisson-Nernst-Planck Equations Using the Hybrid Mixture Theory: Presentation of 2D Numerical Examples

    DEFF Research Database (Denmark)

    Johannesson, Björn

    2010-01-01

    A numerical scheme for the transient solution of generalized version of the Poisson-Nernst-Planck equations is presented. The finite element method is used to establish the coupled non-linear matrix system of equations capable of solving the present problem iteratively. The Poisson-Nernst-Planck ......A numerical scheme for the transient solution of generalized version of the Poisson-Nernst-Planck equations is presented. The finite element method is used to establish the coupled non-linear matrix system of equations capable of solving the present problem iteratively. The Poisson......, however, coupled in both directions. The governed set of equations is derived from a simplified version of the so-called hybrid mixture theory (HMT). This theory is a special version of the more ‘classical’ continuum mixture theories in the sense that it works with averaged equations at macro...

  20. Hybrid Algorithms for Solving Variational Inequalities, Variational Inclusions, Mixed Equilibria, and Fixed Point Problems

    Directory of Open Access Journals (Sweden)

    Lu-Chuan Ceng

    2014-01-01

    Full Text Available We present a hybrid iterative algorithm for finding a common element of the set of solutions of a finite family of generalized mixed equilibrium problems, the set of solutions of a finite family of variational inequalities for inverse strong monotone mappings, the set of fixed points of an infinite family of nonexpansive mappings, and the set of solutions of a variational inclusion in a real Hilbert space. Furthermore, we prove that the proposed hybrid iterative algorithm has strong convergence under some mild conditions imposed on algorithm parameters. Here, our hybrid algorithm is based on Korpelevič’s extragradient method, hybrid steepest-descent method, and viscosity approximation method.

  1. Pharmacotherapy for mild hypertension

    Directory of Open Access Journals (Sweden)

    Diana Diao

    Full Text Available BACKGROUND: People with no previous cardiovascular events or cardiovascular disease represent a primary prevention population. The benefits and harms of treating mild hypertension in primary prevention patients are not known at present. This review examines the existing randomized controlled trial (RCT evidence. OBJECTIVE: Primary objective: To quantify the effects of antihypertensive drug therapy on mortality and morbidity in adults with mild hypertension (systolic blood pressure (BP 140-159 mmHg and/or diastolic BP 90-99 mmHg and without cardiovascular disease. METHODS: Search: We searched CENTRAL (2011, Issue 1, MEDLINE (1948 to May 2011, EMBASE (1980 to May 2011 and reference lists of articles. The Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effectiveness (DARE were searched for previous reviews and meta-analyses of anti-hypertensive drug treatment compared to placebo or no treatment trials up until the end of 2011. Selection criteria: RCTs of at least 1 year duration. Data collection and analysis: The outcomes assessed were mortality, stroke, coronary heart disease (CHD, total cardiovascular events (CVS, and withdrawals due to adverse effects. MAIN RESULTS: Of 11 RCTs identified 4 were included in this review, with 8,912 participants. Treatment for 4 to 5 years with antihypertensive drugs as compared to placebo did not reduce total mortality (RR 0.85, 95% CI 0.63, 1.15. In 7,080 participants treatment with antihypertensive drugs as compared to placebo did not reduce coronary heart disease (RR 1.12, 95% CI 0.80, 1.57, stroke (RR 0.51, 95% CI 0.24, 1.08, or total cardiovascular events (RR 0.97, 95% CI 0.72, 1.32. Withdrawals due to adverse effects were increased by drug therapy (RR 4.80, 95% CI 4.14, 5.57, ARR 9%. AUTHORS' CONCLUSIONS: Antihypertensive drugs used in the treatment of adults (primary prevention with mild hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHg have not been

  2. Pharmacotherapy for mild hypertension

    Directory of Open Access Journals (Sweden)

    Diana Diao

    2012-01-01

    Full Text Available BACKGROUND: People with no previous cardiovascular events or cardiovascular disease represent a primary prevention population. The benefits and harms of treating mild hypertension in primary prevention patients are not known at present. This review examines the existing randomized controlled trial (RCT evidence. OBJECTIVE: Primary objective: To quantify the effects of antihypertensive drug therapy on mortality and morbidity in adults with mild hypertension (systolic blood pressure (BP 140-159 mmHg and/or diastolic BP 90-99 mmHg and without cardiovascular disease. METHODS: Search: We searched CENTRAL (2011, Issue 1, MEDLINE (1948 to May 2011, EMBASE (1980 to May 2011 and reference lists of articles. The Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effectiveness (DARE were searched for previous reviews and meta-analyses of anti-hypertensive drug treatment compared to placebo or no treatment trials up until the end of 2011. Selection criteria: RCTs of at least 1 year duration. Data collection and analysis: The outcomes assessed were mortality, stroke, coronary heart disease (CHD, total cardiovascular events (CVS, and withdrawals due to adverse effects. MAIN RESULTS: Of 11 RCTs identified 4 were included in this review, with 8,912 participants. Treatment for 4 to 5 years with antihypertensive drugs as compared to placebo did not reduce total mortality (RR 0.85, 95% CI 0.63, 1.15. In 7,080 participants treatment with antihypertensive drugs as compared to placebo did not reduce coronary heart disease (RR 1.12, 95% CI 0.80, 1.57, stroke (RR 0.51, 95% CI 0.24, 1.08, or total cardiovascular events (RR 0.97, 95% CI 0.72, 1.32. Withdrawals due to adverse effects were increased by drug therapy (RR 4.80, 95% CI 4.14, 5.57, ARR 9%. AUTHORS' CONCLUSIONS: Antihypertensive drugs used in the treatment of adults (primary prevention with mild hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHg have not been

  3. The Presentation of a Two Stages Model for an Optimum Operation of a Hybrid System of Wind-Pumped Storage Power Plant in the Power Market Environment

    Directory of Open Access Journals (Sweden)

    Mehdi Akbarpour

    2012-11-01

    Full Text Available In this study we present a new method in power market environment. One of the weaknesses in the utilization of wind units is severe dependence of output power level on wind. However, considering the high uncertainty in the prediction of wind speed and wind forecast unit production capacity is also having an error. Also, regarding to the uncontrollable generators of this type, it is better to use combined systems for utilization. This study presents a new model based on the a two stage for an optimum operation of a hybrid system of windpumped storage power plant in the power market environment that causes to provide a successful presentation condition in market environments for the producers of wind power. In the suggestive hybrid system of windpumped storage power plant of this study the modeling is done in two stages for the optimum presence in power market environment with the a most possible benefit. At first, the suggestive model is optimized regarding to uncertainty in the prediction of power price and producing the wind power, for presenting the suggestion of power to market, in order to gain the most benefit. At the second stage, the suggestive model is optimized regarding to uncertainty in producing wind power, in order to gain the most benefit and paying the least penalty for unbalancing in market for operation of the system. In this study, the Particle Swarm Optimization algorithm (PSO is used for optimization. At the end of a model example for applying the results of the proposed model will be examined and analyzes the results. Results show that the model is an appropriate method for the operation of this combined system in market environment.

  4. Quantification of volumetric cerebral blood flow using hybrid laser speckle contract and optical coherence tomography (Conference Presentation)

    Science.gov (United States)

    Valim, Niksa; Dunn, Andrew K.

    2016-03-01

    Studying neurovascular blood flow function in cerebrovascular activities requires accurate visualization and characterization of blood flow volume as well as the dynamics of blood cells in microcirculation. In this study, we present a novel integration of laser speckle contrast imaging (LSCI) and spectral domain optical coherence tomography (SD-OCT) for rapid volumetric imaging of blood flow in cortical capillaries. LSCI uses the illumination of wide-field near infrared light (NIR) and monitors back scattered light to characterize the relative dynamics of blood flow in microcirculation. Absolute measurement of blood cells and blood volume requires high-resolution volumetric structural information. SD-OCT system uses coherence gating to measure scattered light from a small volume within high structural resolution. The structural imaging system rapidly assesses large number of capillaries for spatio-temporal tracking of red blood cells (RBC). A very fast-ultra resolution SD-OCT system was developed for imaging high-resolution volumetric samples. The system employed an ultra wideband light source (1310 ± 200 nm in wavelength) corresponding to an axial resolution of 3 micrometers in tissue. The spectrometer of the SD-OCT was customized for a maximum scanning rate of 147,000 line/s. We demonstrated a fast volumetric OCT angiography algorithm to visualize large numbers of vessels in a 2-mm deep sample volume. A LSCI system that has been developed previously in our group was integrated to the imaging system for the characterization of dynamic blood cells. The conjunction data from LSCI and SD-OCT systems imply the feasibility of accurate quantification of absolute cortical blood flow.

  5. Structural studies of the protein endostatin in fusion with BAX BH3 death domain, a hybrid that presents enhanced antitumoral activity.

    Science.gov (United States)

    Chura-Chambi, Rosa Maria; Arcuri, Helen Andrade; Lino, Felipe; Versati, Natan; Palma, Mario Sergio; Favaro, Denize C; Morganti, Ligia

    2017-05-01

    Endostatin (ES) is an antiangiogenic protein that exhibits antitumor activity in animal models. However, the activity observed in animals was not observed in human clinical trials. ES-BAX is a fusion protein composed of two functional domains: ES, which presents specificity and is internalized by activated endothelial cells and the proapoptotic BH3 domain of the protein BAX, a peptide inductor of cellular death when internalized. We have previously shown (Chura-Chambi et al., Cell Death Dis, 5, e1371, 2014) that ES-BAX presents improved antitumor activity in relation to wild-type ES. Secondary and tertiary structures of ES-BAX are similar to ES, as indicated by homology-modeling studies and molecular dynamics simulations. Tryptophan intrinsic fluorescence and circular dichroism spectroscopy corroborate these data. (15) N HSQC NMR indicates that ES-BAX is structured, but some ES residues have suffered chemical shift perturbations, suggesting that the BH3 peptide interacts with some parts of the ES protein. ES and ES-BAX present similar stability to thermal denaturation. The production of stable hybrid proteins can be a new approach to the development of therapeutic agents presenting specificity for tumoral endothelium and improved antitumor effect. © 2016 International Union of Biochemistry and Molecular Biology, Inc.

  6. Fluorescent nanodiamond and lanthanide labelled in situ hybridization for the identification of RNA transcripts in fixed and CLARITY-cleared central nervous system tissues (Conference Presentation)

    Science.gov (United States)

    Parker, Lindsay M.; Staikopoulos, Vicky; Cordina, Nicole M.; Sayyadi, Nima; Hutchinson, Mark R.; Packer, Nicolle H.

    2016-03-01

    Despite significant advancement in the methodology used to conjugate, incorporate and visualize fluorescent molecules at the cellular and tissue levels, biomedical imaging predominantly relies on the limitations of established fluorescent molecules such as fluorescein, cyanine and AlexaFluor dyes or genetic incorporation of fluorescent proteins by viral or other means. These fluorescent dyes and conjugates are highly susceptible to photobleaching and compete with cellular autofluorescence, making biomedical imaging unreliable, difficult and time consuming in many cases. In addition, some proteins have low copy numbers and/or poor antibody recognition, further making detection and imaging difficult. We are developing better methods for imaging central nervous system neuroinflammatory markers using targeted mRNA transcripts labelled with fluorescent nanodiamonds or lanthanide chelates. These tags have increased signal and photostability and can also discriminate against tissue/cell autofluorescence. Brains and spinal cords from BALB/c mice with a chronic constriction model of neuropathic pain (neuroinflammation group) or that have undergone sham surgeries (control group) were collected. A subset of brains and spinal cords were perfused and fixed with paraformaldehyde (n=3 sham and n=3 pain groups) prior to sectioning and in situ hybridization using nanodiamond or lanthanide chelate conjugated complementary RNA probes. Another subset of brains and spinal cords from the same cohort of animals were perfused and processed for CLARITY hydrogel based clearing prior to in situ hybridization with the same probes. We will present our findings on the photostability, sensitivity and discrimination from background tissue autofluorescence of our novel RNA probes, compared to traditional fluorophore tags.

  7. Mild cognitive impairment

    Directory of Open Access Journals (Sweden)

    Pavlović Dragan M.

    2009-01-01

    Full Text Available Mild cognitive impairment (MCI is a syndrome that spans the area between normal ageing and dementia. It is classified into amnestic and non-amnestic types, both with two subtypes: single domain and multiple domains. Prevalence of MCI depends on criteria and population and can vary from 0.1 to 42% persons of older age. In contrast to dementia, cognitive deterioration is less severe and activities of daily living are preserved. Most impaired higher cognitive functions in MCI are memory, executive functions, language, visuospatial functions, attention etc. Also there are depression, apathy or psychomotor agitation, and signs of psychosis. Aetiology of MCI is multiple, mostly neurodegenerative, vascular, psychiatric, internistic, neurological, traumatic and iatrogenic. Persons with amnestic MCI are at a higher risk of converting to Alzheimer's disease, while those with a single non-memory domain are at risk of developing frontotemporal dementia. Some MCI patients also progress to other dementia types, vascular among others. In contrast, some patients have a stationary course, some improve, while others even normalize. Every suspicion of MCI warrants a detailed clinical exploration to discover underlying aetiology, laboratory analyses, neuroimaging methods and some cases require a detailed neuropsychological assessment. At the present time there is no efficacious therapy for cognitive decline in MCI or the one that could postpone conversion to dementia. The treatment of curable causes, application of preventive measures and risk factor control are reasonable measures in the absence of specific therapy.

  8. Mild Slope Ligningen

    DEFF Research Database (Denmark)

    Brorsen, Michael

    Der gives en beskrivelse af forudsætningerne for Mild Slope ligningen, som kort fortalt kan benyttes til at beregne harmoniske, lineære bølger i områder med "små" gradienter på dybderne.......Der gives en beskrivelse af forudsætningerne for Mild Slope ligningen, som kort fortalt kan benyttes til at beregne harmoniske, lineære bølger i områder med "små" gradienter på dybderne....

  9. [Mild brain injuries in emergency medicine].

    Science.gov (United States)

    Liimatainen, Suvi; Niskakangas, Tero; Ohman, Juha

    2011-01-01

    Diagnostics and correct classification of mild brain injuries is challenging. Problems caused by insufficient documentation at the acute phase become more obvious in situations in which legal insurance issues are to be considered. A small proportion of patients with mild brain injury suffer from prolonged symptoms. Medical recording and classification of the brain injury at the initial phase should therefore be carried out in a structured manner. The review deals with the diagnostic problems of mild brain injuries and presents a treatment protocol for adult patients at the acute phase, aiming at avoiding prolonged problems.

  10. Mild induced hypothermia

    DEFF Research Database (Denmark)

    Johansen, Maria E; Jensen, Jens-Ulrik; Bestle, Morten H

    2014-01-01

    INTRODUCTION: Coagulopathy associates with poor outcome in sepsis. Mild induced hypothermia has been proposed as treatment in sepsis but it is not known whether this intervention worsens functional coagulopathy. MATERIALS AND METHODS: Interim analysis data from an ongoing randomized controlled tr...

  11. Mild Cognitive Impairment (MCI)

    Science.gov (United States)

    ... stage between the expected cognitive decline of normal aging and the more-serious decline of dementia. It can involve problems with memory, language, thinking and judgment that are greater than normal age-related changes. If you have mild cognitive impairment, you may ...

  12. Curating a Mild Apocalypse

    DEFF Research Database (Denmark)

    Brichet, Nathalia Sofie; Hastrup, Frida

    2017-01-01

    On the basis of our exhibition “Mild Apocalypse. Feral Landscapes in Denmark” (2016) we discuss how we curated insights generated in a collaborative cross-disciplinary research project about a former mining site in Denmark. We approach this industrially disturbed and radically altered landscape......-based curating must follow suit by creating novel objects, thereby making exhibitions into provisional analyses and blurring conventional lines between art galleries and museums of cultural history....

  13. Curating a Mild Apocalypse

    DEFF Research Database (Denmark)

    Brichet, Nathalia Sofie; Hastrup, Frida

    2017-01-01

    that often go unnoticed? We argue that exhibition work when practiced as a form of research provides an opportunity for turning “trivial” environmental disaster into sensational experience by deliberately playing with objects to make what we think of as analytical figures. That is, exhibition artefacts...... as an effect of the so-called Anthropocene era, but one which is in a sense insignificant and undramatic – a mild apocalypse. This poses a challenge to both our anthropological research and our curatorial practices: how do we bring the Anthropocene home and draw attention to the inconspicuous disasters...

  14. EXTENDED MILD-SLOPE EQUATION

    Institute of Scientific and Technical Information of China (English)

    黄虎; 丁平兴; 吕秀红

    2001-01-01

    The Hamiltonian formalism for surface waves and the mild-slope approximation were empolyed in handling the case of slowly varying three-dimensional currents and an uneven bottom, thus leading to an extended mild-slope equation. The bottom topography consists of two components: the slowly varying component whose horizontal length scale is longer than the surface wave length, and the fast varying component with the amplitude being smaller than that of the surface wave. The frequency of the fast varying depth component is, however, comparable to that of the surface waves. The extended mild- slope equation is more widely applicable and contains as special cases famous mild-slope equations below: the classical mild-slope equation of Berkhoff , Kirby' s mild-slope equation with current, and Dingemans' s mild-slope equation for rippled bed. The extended shallow water equations for ambient currents and rapidly varying topography are also obtained.

  15. Military Hybrid Vehicle Survey

    Science.gov (United States)

    2011-08-03

    Furthermore, a standard duty cycle that is accepted for measuring fuel economy does not exist nor does a focus towards a particular technology. This...expanded into mild hybrid with the addition of a clutch connecting the generator to the transmission and additional energy storage [16-17...speed control and one for engine/generator torque [35]. Urban, Highway, Composite 33%, 27.9%, 49% General vehicle simulation [30]. Urban 19.0

  16. Half-Antibody Functionalized Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen (CEA) Presenting Pancreatic Cancer Cells

    Science.gov (United States)

    Hu, Che-Ming Jack; Kaushal, Sharmeela; Tran Cao, Hop S.; Aryal, Santosh; Sartor, Marta; Esener, Sadik; Bouvet, Michael; Zhang, Liangfang

    2010-01-01

    Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-CEA half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding non-targeted nanoparticles. PMID:20394436

  17. The increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh since the emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients.

    Science.gov (United States)

    Chowdhury, Fahima; Kuchta, Alison; Khan, Ashraful Islam; Faruque, A S G; Calderwood, Stephen B; Ryan, Edward T; Qadri, Firdausi

    2015-11-01

    A hybrid strain of Vibrio cholerae O1 El Tor that expresses a classical cholera toxin (CT) emerged in 2001. This hybrid variant rapidly replaced the previous El Tor strain around the world. The global emergence of this variant coincided with anecdotal reports that cholera patients were presenting with more severe dehydration and disease in many locations. A comparison was made of the severity of disease before and after the emergence of the hybrid strain in cholera patients attending an icddr,b hospital in Dhaka, Bangladesh. It was found that cholera patients presented with more severe dehydration and severe disease in the later period. However, this was also true for all non-cholera patients as well. In addition, in sub-analyses of patients who presented with rotavirus and enterotoxigenic Escherichia coli (ETEC), similar results were found. Comparing the two periods for differences in patient characteristics, nutritional status, vaccination status, and income, no plausible cause for patients presenting with more severe disease was identified in the later period. As a shift in severity for both cholera and non-cholera was observed, these results indicate that the altered El Tor strain cannot fully explain the difference in cholera severity before and after 2001. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh Since emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients

    Science.gov (United States)

    Chowdhury, Fahima; Kuchta, Alison; Khan, Ashraful Islam; Faruque, ASG; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi

    2015-01-01

    In 2001, a hybrid strain of Vibrio cholerae O1 El Tor that expresses a classical cholera toxin (CT) emerged and this hybrid variant rapidly replaced the previous El Tor strain around the world. The global emergence of this variant coincided with anecdotal reports that cholera patients were presenting with more severe dehydration and disease in many locations. We compared severity of disease in cholera patients from before and after emergence of the hybrid strain at a diarrheal hospital in Dhaka, Bangladesh. We did indeed find that cholera patients presented with more severe dehydration and severe disease in the latter period; however, this was also true for “all non-cholera patients” as well. In addition, in sub-analyses of patients who presented with rotavirus and enterotoxigenic E. coli (ETEC), we found similar results. Comparing the two periods for differences in patient characteristics, nutritional status, vaccination status and income, we were unable to detect a plausible cause for patients presenting with more severe disease in the latter period. Because we observed a shift in severity for both cholera and non-cholera, our results indicate that the altered El Tor strain cannot fully explain the differences in cholera severity before and after 2001 PMID:26409202

  19. On Fractional Order Hybrid Differential Equations

    Directory of Open Access Journals (Sweden)

    Mohamed A. E. Herzallah

    2014-01-01

    Full Text Available We develop the theory of fractional hybrid differential equations with linear and nonlinear perturbations involving the Caputo fractional derivative of order 0<α<1. Using some fixed point theorems we prove the existence of mild solutions for two types of hybrid equations. Examples are given to illustrate the obtained results.

  20. The hydrogen hybrid option

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.R.

    1993-10-15

    The energy efficiency of various piston engine options for series hybrid automobiles are compared with conventional, battery powered electric, and proton exchange membrane (PEM) fuel cell hybrid automobiles. Gasoline, compressed natural gas (CNG), and hydrogen are considered for these hybrids. The engine and fuel comparisons are done on a basis of equal vehicle weight, drag, and rolling resistance. The relative emissions of these various fueled vehicle options are also presented. It is concluded that a highly optimized, hydrogen fueled, piston engine, series electric hybrid automobile will have efficiency comparable to a similar fuel cell hybrid automobile and will have fewer total emissions than the battery powered vehicle, even without a catalyst.

  1. 一例以不育为主诉的极轻型胆固醇侧链裂解酶缺陷症%Extremely mild cholesterol side chain cleavage enzyme deficiency with infertility as the only presenting complaint

    Institute of Scientific and Technical Information of China (English)

    孙首悦; 宁光; 叶蕾; 陆洁莉; 顾卫琼; 苏颋为; 谢静; 周晓艺; 韩如来; 王卫庆

    2016-01-01

    已经报道的胆固醇侧链裂解酶(P450cc)缺陷症均表现为肾上腺皮质功能不全。本文报道了1例以不育为主诉的成人男性极轻型P450cc缺陷症。患者曾因不育就诊于泌尿外科,有双侧睾丸间质细胞瘤手术病史。入住本院内分泌科后进一步病理学分析提示睾丸残余肾上腺瘤,结合患者极高的血浆ACTH、双侧肾上腺增生,诊断为先天性肾上腺皮质增生症。进一步基因筛查发现 CYP11A1R353W和CYP11A1P432L复合杂合突变,患者最终确诊为P450cc缺陷症。%[Summary] All patients with cholesterol side-chain cleavage enzyme ( P450scc) deficiency that have been reported presented with early adrenal failure. Here we described a 35-year-old male presented with infertility as the only initial presenting complaint. He had received two separate surgeries to remove bilateral testicular masses. We reevaluated the resected tumors and found testicular adrenal rest tumor ( TART) pathology in the resected tumor. We profiled steroid hormones and found significantly elevated ACTH. CT scan revealed bilateral adrenal hyperplasia. Mutation screening identified compound heterozygous mutations (R353W and P432L) in the P450scc encoding gene (CYP11A1). The patient was finally diagnosed as congenital adrenal hyperplasia.

  2. Cognitive Processing in Mild Disabilities.

    Science.gov (United States)

    Al-Hilawani, Yasser A.; Poteet, James A.

    Research regarding the cognitive processing of students with learning disabilities, mild mental handicap, and emotional handicap is reviewed. In considering cognitive processing for students with mild mental handicap, research attention has been directed to the issues of memory and learning, acquisition and retrieval deficits, inefficient…

  3. Heterogeneity in executive impairment in patients with very mild Alzheimer's

    DEFF Research Database (Denmark)

    Stokholm, J.; Gade, Anders; Vogel, A.

    2006-01-01

    The presence of executive impairment in mild Alzheimer's disease (AD) has primarily been demonstrated by means of group comparison. Whether executive dysfunction is a common feature of mild AD or only present in a subgroup of patients remains unclear. The aim of this study was to describe...

  4. Hybrid intelligent engineering systems

    CERN Document Server

    Jain, L C; Adelaide, Australia University of

    1997-01-01

    This book on hybrid intelligent engineering systems is unique, in the sense that it presents the integration of expert systems, neural networks, fuzzy systems, genetic algorithms, and chaos engineering. It shows that these new techniques enhance the capabilities of one another. A number of hybrid systems for solving engineering problems are presented.

  5. Editorial: Hybrid Systems

    DEFF Research Database (Denmark)

    Olderog, Ernst-Rüdiger; Ravn, Anders Peter

    2007-01-01

    An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005.......An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005....

  6. Dysphagia is present but mild in myotonic dystrophy type 2

    NARCIS (Netherlands)

    R. Ensink; S. Knuijt; Baziel van Engelen; J. van Vliet; A. Tieleman; Bert de Swart

    2009-01-01

    The phenotype of myotonic dystrophy type 2 (DM2) shows similarities as well as differences to that of myotonic dystrophy type 1 (DM1). Dysphagia, a predominant feature in DM1, has not yet been examined in DM2. In a recent nationwide questionnaire survey of gastrointestinal symptoms in DM2, 12 out of

  7. Dysphagia is present but mild in myotonic dystrophy type 2.

    NARCIS (Netherlands)

    Tieleman, A.A.; Knuijt, S.; Vliet, J. van; Swart, B.J.M. de; Ensink, R.J.H.; Engelen, B.G.M. van

    2009-01-01

    The phenotype of myotonic dystrophy type 2 (DM2) shows similarities as well as differences to that of myotonic dystrophy type 1 (DM1). Dysphagia, a predominant feature in DM1, has not yet been examined in DM2. In a recent nationwide questionnaire survey of gastrointestinal symptoms in DM2, 12 out of

  8. Dysphagia is present but mild in myotonic dystrophy type 2

    NARCIS (Netherlands)

    Swart, Bert de; Tieleman, A.; Knuijt, S.; Vliet, J. van; Ensink, R.; Engelen, Baziel van

    2009-01-01

    The phenotype of myotonic dystrophy type 2 (DM2) shows similarities as well as differences to that of myotonic dystrophy type 1 (DM1). Dysphagia, a predominant feature in DM1, has not yet been examined in DM2. In a recent nationwide questionnaire survey of gastrointestinal symptoms in DM2, 12 out of

  9. A Mathematical Approach to Hybridization

    Science.gov (United States)

    Matthews, P. S. C.; Thompson, J. J.

    1975-01-01

    Presents an approach to hybridization which exploits the similarities between the algebra of wave functions and vectors. This method will account satisfactorily for the number of orbitals formed when applied to hybrids involving the s and p orbitals. (GS)

  10. Hybrid Baryons

    CERN Document Server

    Page, P R

    2003-01-01

    We review the status of hybrid baryons. The only known way to study hybrids rigorously is via excited adiabatic potentials. Hybrids can be modelled by both the bag and flux-tube models. The low-lying hybrid baryon is N 1/2^+ with a mass of 1.5-1.8 GeV. Hybrid baryons can be produced in the glue-rich processes of diffractive gamma N and pi N production, Psi decays and p pbar annihilation.

  11. Repetition priming in mild cognitive impairment and mild dementia: Impact of educational attainment.

    Science.gov (United States)

    O'Shea, Deirdre M; De Wit, Liselotte; Yutsis, Maya; Castro, Melissa; Smith, Glenn E

    2017-07-03

    To examine the role of education on repetition priming performances in healthy aging, mild cognitive impairment (MCI), and mild dementia. A total of 72 participants (healthy = 27, with MCI = 28, with mild dementia = 17) took part in the present study. Priming was assessed using the Word Stem Completion Test, and delayed and recognition memory was assessed using the Rey Auditory Verbal Learning Test. A multinomial regression analysis was used to examine whether years of education moderated priming and declarative memory performances in predicting group membership. Priming performances discriminated between individuals with MCI and mild dementia but not between MCI and healthy. Additionally, this effect was most salient in individuals with low levels of education. Education did not moderate explicit memory performances in predicting group membership. Little is known about the impact of education on priming in verbal memory. Our findings indicate that formal years of education impact priming performances in MCI and individuals with mild dementia, which may have implications for designing interventions targeting "intact" cognitive abilities in these groups.

  12. Hybrid trajectory spaces

    NARCIS (Netherlands)

    Collins, P.J.

    2005-01-01

    In this paper, we present a general framework for describing and studying hybrid systems. We represent the trajectories of the system as functions on a hybrid time domain, and the system itself by its trajectory space, which is the set of all possible trajectories. The trajectory space is given a na

  13. Interstitial deletion of chromosome 4p associated with mild mental retardation, epilepsy and polymicrogyria of the left temporal lobe

    DEFF Research Database (Denmark)

    Møller, R S; Hansen, C P; Jackson, G D

    2007-01-01

    In this study, we present a 38-year-old woman with an interstitial deletion of 4p15.1-15.3, mild mental retardation, epilepsy and polymicrogyria adjacent to an arachnoid cyst of the left temporal lobe. The deletion was ascertained through array-comparative genome hybridization screening of patien...... described in this study were similar but not identical to the previously reported cases with 4p15 interstitial deletions. This finding indicates the presence of one or more genes involved in brain development and epilepsy in this chromosome region.......In this study, we present a 38-year-old woman with an interstitial deletion of 4p15.1-15.3, mild mental retardation, epilepsy and polymicrogyria adjacent to an arachnoid cyst of the left temporal lobe. The deletion was ascertained through array-comparative genome hybridization screening of patients...... with epilepsy and brain malformations. To date, about 35 patients with cytogenetically visible deletions involving 4p15 and without Wolf-Hirschhorn syndrome have been described, but the extent of the deletions has not been determined in the majority of these cases. The clinical manifestations of the patient...

  14. Synthesis and Characterization of Novel Epoxy Geopolymer Hybrid Composites

    Directory of Open Access Journals (Sweden)

    Oreste Tarallo

    2013-09-01

    Full Text Available The preparation and the characterization of novel geopolymer-based hybrid composites are reported. These materials have been prepared through an innovative synthetic approach, based on a co-reticulation in mild conditions of commercial epoxy based organic resins and a metakaolin-based geopolymer inorganic matrix. This synthetic strategy allows the obtainment of a homogeneous dispersion of the organic particles in the inorganic matrix, up to 25% in weight of the resin. The materials obtained present significantly enhanced compressive strengths and toughness with respect to the neat geopolymer, suggesting their wide utilization for structural applications. A preliminary characterization of the porous materials obtained by removing the organic phase from the hybrid composites by means of heat treatments is also reported. Possible applications of these materials in the field of water purification, filtration, or as lightweight insulating materials are envisaged.

  15. Mild cognitive impairment in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    LUO Xiao-guang

    2013-08-01

    Full Text Available Cognitive impairment is one of the most common non-motor symptoms of Parkinson's disease (PD and a major influencing factor on patients' daily living ability. Mild cognitive impairment (MCI is a cognitive state between normal aging and dementia, and the living capability of MCI patients relatively remains. MCI often occurs in PD, with its clinical features presenting as the impairment in working memory and (or attention, executive function, language ability, memory and visuospatial function. Here we try to depict the general picture of PD-MCI from the view of epidemiology, pathology, clinical presentation, imaging and diagnostic criteria.

  16. Hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    West, J.G.W. [Electrical Machines (United Kingdom)

    1997-07-01

    The reasons for adopting hybrid vehicles result mainly from the lack of adequate range from electric vehicles at an acceptable cost. Hybrids can offer significant improvements in emissions and fuel economy. Series and parallel hybrids are compared. A combination of series and parallel operation would be the ideal. This can be obtained using a planetary gearbox as a power split device allowing a small generator to transfer power to the propulsion motor giving the effect of a CVT. It allows the engine to run at semi-constant speed giving better fuel economy and reduced emissions. Hybrid car developments are described that show the wide range of possible hybrid systems. (author)

  17. MILD BLEEDERS: DIAGNOSIS IS ELUSIVE IN LARGE NUMBER OF PATIENTS

    Directory of Open Access Journals (Sweden)

    Mrinalini kotru

    2016-10-01

    Full Text Available Abstract. Background: Bleeding is a common clinical presentation. Even patients with mild bleeding disorders are extensively investigated for ascertaining the cause. The present study was conducted in order to evaluate the extent of the possibility of diagnosis in mild bleeding disorders. Material and Methods: This was a prospective study of patients referred for work up of mild bleeding for a period of 13 months. A complete blood count, peripheral smear examination, Prothrombin time, Partial Thromboplastin time and Thrombin Time, Platelet Aggregometry test, tests for von Willebrand’s disease and Platelet function 3 availability were measured. Results: 164 patients presented with mild bleeding, in 114 of the  patients a single site of bleeding was present. Epistaxis was the most common presentation (39%. Cutaneous bleeding (petechiae and purpura was the next common site. History of a major bleeding tendency in the family was present only in 11 patients. The investigations showed that VWD (17/164, followed by clotting disorders (CD mainly mild hemophilia (15/164 were the most common diagnosable cause. There were also 4 cases of hypofibrinogenemia. The disorders of platelets (Platelet function defects/PFD were the least common (9/164. Rest 123 (75% patients could not be diagnosed on the basis of these investigations and were labeled as  Bleeding disorders – Unclassified (BDC. Conclusion: n our study, 75% of the patients with mild bleeding remained undiagnosed even after extensive laboratory workup, thus raising a very pertinent question that is it necessary that all mild bleeders submit to a broad battery of investigations, as the diagnosis continues to be elusive despite extensive workup.

  18. Emotion-discrimination deficits in mild Alzheimer disease.

    Science.gov (United States)

    Kohler, Christian G; Anselmo-Gallagher, Gerri; Bilker, Warren; Karlawish, Jason; Gur, Raquel E; Clark, Christopher M

    2005-11-01

    Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers. Twenty AD subjects and 22 caretakers underwent computerized testing of emotion recognition and differentiation. Performances between groups were compared, controlling for possible effects of age and cognitive abilities. AD subjects showed diminished recognition of happy, sad, fearful, and neutral expressions. They also exhibited decreased differentiation between happy and sad expressions. Controlling for effects of cognitive dysfunction, AD subjects differed on recognition of happy and sad, and differentiation of sad facial expressions, and in error patterns for fearful and neutral faces. Diminished abilities for emotion discrimination are present in persons with mild AD. In persons with mild AD, who frequently reside in their own home or with close family, this diminished ability may adversely affect social functioning and quality of life.

  19. Advanced Hybrid Computer Systems. Software Technology.

    Science.gov (United States)

    This software technology final report evaluates advances made in Advanced Hybrid Computer System software technology . The report describes what...automatic patching software is available as well as which analog/hybrid programming languages would be most feasible for the Advanced Hybrid Computer...compiler software . The problem of how software would interface with the hybrid system is also presented.

  20. Iloprost inhalation in mild asthma.

    Science.gov (United States)

    Majeski, Elizabeth; Hoskins, Aimee; Dworski, Ryszard; Sheller, James R

    2012-11-01

    To determine the feasibility of administering iloprost by inhalation in patients with mild atopic asthma. Volunteers underwent supervised inhalation of iloprost in the clinic with measurement of spirometry and blood pressure for 2 hours. The volunteers then inhaled iloprost four times daily at a dose of 2.5 or 5 μg for 14 days. Spirometry, asthma questionnaires, peak flow diaries, measurement of methacholine responsiveness, and exhaled nitric oxide concentrations were obtained prior to and after the treatment period. Chronic inhalation of iloprost (2.5-5 μg) did not alter spirometry or methacholine responsiveness. Inhaled iloprost in carefully selected volunteers with mild asthma appears to be a suitable intervention to explore the effects of prostacyclin in human asthma.

  1. Hybridized tetraquarks

    Directory of Open Access Journals (Sweden)

    A. Esposito

    2016-07-01

    Full Text Available We propose a new interpretation of the neutral and charged X,Z exotic hadron resonances. Hybridized-tetraquarks are neither purely compact tetraquark states nor bound or loosely bound molecules but rather a manifestation of the interplay between the two. While meson molecules need a negative or zero binding energy, its counterpart for h-tetraquarks is required to be positive. The formation mechanism of this new class of hadrons is inspired by that of Feshbach metastable states in atomic physics. The recent claim of an exotic resonance in the Bs0π± channel by the D0 Collaboration and the negative result presented subsequently by the LHCb Collaboration are understood in this scheme, together with a considerable portion of available data on X,Z particles. Considerations on a state with the same quantum numbers as the X(5568 are also made.

  2. Hybridized Tetraquarks

    CERN Document Server

    Esposito, A.; Polosa, A.D.

    2016-01-01

    We propose a new interpretation of the neutral and charged X, Z exotic hadron resonances. Hybridized-tetraquarks are neither purely compact tetraquark states nor bound or loosely bound molecules. The latter would require a negative or zero binding energy whose counterpart in h-tetraquarks is a positive quantity. The formation mechanism of this new class of hadrons is inspired by that of Feshbach metastable states in atomic physics. The recent claim of an exotic resonance in the Bs pi+- channel by the D0 collaboration and the negative result presented subsequently by the LHCb collaboration are understood in this scheme, together with a considerable portion of available data on X, Z particles. Considerations on a state with the same quantum numbers as the X(5568) are also made.

  3. Hybrid polypeptides having cellobiohydrolase activity and polynucleotides encoding same

    Science.gov (United States)

    Liu, Ye; Shaghasi, Tarana

    2016-11-01

    The present invention provides hybrid polypeptides having cellobiohydrolase activity. The present invention also provides polynucleotides encoding the hybrid polypeptides; nucleic acid constructs, vectors and host cells comprising the polynucleotides; and processes of using the hybrid polypeptides.

  4. Tandem inversion duplication within F8 Intron 1 associated with mild haemophilia A.

    Science.gov (United States)

    Lannoy, N; Bandelier, C; Grisart, B; Reginster, M; Ronge-Collard, E; Vikkula, M; Hermans, C

    2015-07-01

    In approximately 90% of mild haemophilia A (HA) patients, a missense mutation can be identified using complete gene sequencing. In this study, multiplex ligation-dependent probe amplification analysis was performed as a second step in 10 French-speaking Belgian with mild HA presenting no detectable causal mutation by complete sequencing of the factor VIII (FVIII) (F8) gene's 26 exons and its 1.2 kb of contiguous promoter sequence. This gene dosage technique enabled the detection of exon 1 duplications of F8 in three apparently unrelated subjects. Using array-comparative genomic hybridization, breakpoint analysis delimited the duplication extent to 210 kb in the F8 intron 1 and VBP1 gene intragenic position. We postulated that the rearrangement responsible for this duplication, never before reported, could be attributed to a symmetrical tandem inversion duplication, resulting in a large 233 kb rearrangement of F8 intron 1. This rearranged intron should lead to the production of a small number of normal mRNA transcripts in relation to the mild HA phenotype. Our analysis of the entire F8 mRNA from index case 1, particularly the segment containing exons 1-9, revealed normal amplification and sequencing. Reduced plasma FVIII antigen levels caused by cross-reacting material is associated with a quantitative deficiency of plasma FVIII. Male patients were unresponsive to desmopressin (1-deamino-8-D-arginine vasopressin). All patients displayed identical F8 haplotypes, despite not being related, which suggests a possible founder effect caused by a 210 kb duplication involving F8 exon 1.

  5. Ants exhibit asymmetric hybridization in a mosaic hybrid zone.

    Science.gov (United States)

    Purcell, Jessica; Zahnd, Sacha; Athanasiades, Anouk; Türler, Rebecca; Chapuisat, Michel; Brelsford, Alan

    2016-10-01

    Research on hybridization between species provides unparalleled insights into the pre- and postzygotic isolating mechanisms that drive speciation. In social organisms, colony-level incompatibilities may provide additional reproductive barriers not present in solitary species, and hybrid zones offer an opportunity to identify these barriers. Here, we use genotyping-by-sequencing to sequence hundreds of markers in a hybrid zone between two socially polymorphic ant species, Formica selysi and Formica cinerea. We characterize the zone, determine the frequency of hybrid workers, infer whether hybrid queens or males are produced and investigate whether hybridization is influenced by colony social organization. We also compare cuticular hydrocarbon profiles and aggression levels between the two species. The hybrid zone exhibits a mosaic structure. The asymmetric distribution of hybrids skewed towards F. cinerea suggests a pattern of unidirectional nuclear gene flow from F. selysi into F. cinerea. The occurrence of backcrossed individuals indicates that hybrid queens and/or males are fertile, and the presence of the F. cinerea mitochondrial haplotype in 97% of hybrids shows that successful F1 hybrids will generally have F. cinerea mothers and F. selysi fathers. We found no evidence that social organization contributes to speciation, because hybrids occur in both single-queen and multiple-queen colonies. Strongly differentiated cuticular hydrocarbon profiles and heightened interspecific aggression further reveal that species recognition cues are both present and perceived. The discovery of fertile hybrids and asymmetrical gene flow is unusual in ants, and this hybrid zone will therefore provide an ideal system with which to investigate speciation in social insects.

  6. Hybrid photon detectors

    CERN Document Server

    D'Ambrosio, C

    2003-01-01

    Hybrid photon detectors detect light via vacuum photocathodes and accelerate the emitted photoelectrons by an electric field towards inversely polarized silicon anodes, where they are absorbed, thus producing electron-hole pairs. These, in turn, are collected and generate electronic signals on their ohmic contacts. This review first describes the characteristic properties of the main components of hybrid photon detectors: light entrance windows, photocathodes, and silicon anodes. Then, essential relations describing the trajectories of photoelectrons in electric and magnetic fields and their backscattering from the silicon anodes are derived. Depending on their anode configurations, three families of hybrid photon detectors are presented: hybrid photomultiplier tubes with single anodes for photon counting with high sensitivity and for gamma spectroscopy; multi-anode photon detector tubes with anodes subdivided into square or hexagonal pads for position-sensitive photon detection; imaging silicon pixel array t...

  7. Mild behavioral impairment and risk of dementia

    Science.gov (United States)

    Taragano, FE; Allegri, RF; Krupitzki, H; Sarasola, D; Serrano, CM; Loñ, L; Lyketsos, CG

    2009-01-01

    Background Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia, at least for some patients. Behavioral symptoms in MCI are associated with a higher risk of dementia, but their association with dementia risk in patients without MCI is unknown. Mild Behavioral Impairment (MBI) refers to a late life syndrome with prominent psychiatric and related behavioral symptoms in the absence of prominent cognitive symptoms, which may also be a dementia prodrome. Objective To compare MCI and MBI patients and to estimate the risk of dementia development in these two groups. Method A consecutive series of 358 patients (239 with MCI; and 119 with MBI) presenting to an outpatient general hospital specialty clinic were followed for up to 5 years until conversion to dementia or censoring. Results 34% of MCI patients and over 70% of patients with MBI developed dementia (Logrank p=0.011). MBI patients without cognitive symptoms were more likely to develop dementia (Logrank p<0.001). MBI patients were more likely to develop dementia due to frontotemporal degeneration (FTD) as opposed to Alzheimer’s dementia (AD). Conclusion MBI appears to be a transitional state between normal ageing and dementia. MBI (specifically those without cognitive symptoms) may confer a higher risk for dementia than MCI and is likely an FTD prodrome in many cases. These findings have implications for the early detection, prevention, and treatment of patients with dementia in late life, by focusing on the emergence of new behavioral symptoms. PMID:19323967

  8. Hybrid Metaheuristics

    CERN Document Server

    2013-01-01

    The main goal of this book is to provide a state of the art of hybrid metaheuristics. The book provides a complete background that enables readers to design and implement hybrid metaheuristics to solve complex optimization problems (continuous/discrete, mono-objective/multi-objective, optimization under uncertainty) in a diverse range of application domains. Readers learn to solve large scale problems quickly and efficiently combining metaheuristics with complementary metaheuristics, mathematical programming, constraint programming and machine learning. Numerous real-world examples of problems and solutions demonstrate how hybrid metaheuristics are applied in such fields as networks, logistics and transportation, bio-medical, engineering design, scheduling.

  9. Brief report : Adults with mild autism spectrum disorders (ASD): Scores on the autism spectrum quotient (AQ) and comorbid psychopathology

    NARCIS (Netherlands)

    Ketelaars, C.; Horwitz, E.; Sytema, S.; Bos, J.; Wiersma, D.; Minderaa, R.; Hartman, C.A.

    While knowledge about symptom presentation of adults with mild ASD, including comorbid psychopathology, is limited, referral of adults with suspected mild PDD is increasing. We report on pilot research investigating whether patients diagnosed with mild ASD (n = 15) and patients who were not

  10. Brief report : Adults with mild autism spectrum disorders (ASD): Scores on the autism spectrum quotient (AQ) and comorbid psychopathology

    NARCIS (Netherlands)

    Ketelaars, C.; Horwitz, E.; Sytema, S.; Bos, J.; Wiersma, D.; Minderaa, R.; Hartman, C.A.

    2008-01-01

    While knowledge about symptom presentation of adults with mild ASD, including comorbid psychopathology, is limited, referral of adults with suspected mild PDD is increasing. We report on pilot research investigating whether patients diagnosed with mild ASD (n = 15) and patients who were not diagnose

  11. Mild mental stress in diabetes

    DEFF Research Database (Denmark)

    Hildebrandt, P; Mehlsen, J; Sestoft, L

    1985-01-01

    A TV-game of tennis of 20 min duration was used to study the influence of mild mental stress on subcutaneous blood-flow (SBF), blood-pressure and heart rate in nine insulin-dependent diabetics and nine healthy subjects. SBF was measured on the thigh by local clearance of xenon-133. Measurements...... were made before, during and after the period of stress. During stress, SBF increased significantly by 26% in the healthy subjects, while SBF remained unchanged in the diabetics. The difference between the two groups was significant (P less than 0.05). Following stress, SBF returned to pre-stress level...... in the healthy subjects, while a significant decrease of 33% was observed in the diabetics. The pre-stress heart rate level was higher and the stress-induced increase in heart rate was less in the diabetics compared with the healthy subjects (P less than 0.05). During the stress a slight--but insignificant...

  12. How to distinguish Hybrids from Radial Quarkonia

    CERN Document Server

    Close, Francis Edwin; Close, Frank E; Page, Philip R.

    1997-01-01

    We present arguments that reinforce the hybrid interpretation of pi(1800) and we establish that the rho(1450) and the omega(1420) can be interpreted as radial-hybrid mixtures. Some questions for future experiments are raised.

  13. Hybrid intermediaries

    OpenAIRE

    Cetorelli, Nicola

    2014-01-01

    I introduce the concept of hybrid intermediaries: financial conglomerates that control a multiplicity of entity types active in the "assembly line" process of modern financial intermediation, a system that has become known as shadow banking. The complex bank holding companies of today are the best example of hybrid intermediaries, but I argue that financial firms from the "nonbank" space can just as easily evolve into conglomerates with similar organizational structure, thus acquiring the cap...

  14. Hybrid composites

    CSIR Research Space (South Africa)

    Jacob John, Maya

    2009-04-01

    Full Text Available effect was observed for the elongation at break of the hybrid composites. The impact strength of the hybrid composites increased with the addition of glass fibres. The tensile and impact properties of thermoplastic natural rubber reinforced short... panels made from conventional structural materials. Figure 3 illustrates the performance of cellular biocomposite panels against conventional systems used for building and residential construction, namely a pre- cast pre-stressed hollow core concrete...

  15. Understanding mild persistent asthma in children

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Szefler, Stanley J

    2005-01-01

    Limitations in asthma prevalence studies and difficulties in diagnosing pediatric asthma lead to uncertainty over the full extent of mild persistent asthma in children and adolescents. Although recent surveys have reported that the majority of pediatric patients with asthma in the United States...... and Europe have symptoms consistent with mild disease, these surveys have limitations in design. Thus, the true prevalence of mild asthma remains unknown. It is unclear whether children with mild persistent asthma progress to more severe asthma, but the risk of severe asthma exacerbations seems...... to be unrelated to the symptom severity. Clinical studies restricted to pediatric patients with mild asthma are limited, but available data do suggest substantial morbidity of mild persistent asthma in this population and support inhaled corticosteroid intervention. There is a need for further investigation...

  16. Should mild COPD be treated? Evidence for early pharmacological intervention.

    Science.gov (United States)

    Elbehairy, Amany F; Webb, Katherine A; Neder, J Alberto; Alberto Neder, J; O'Donnell, Denis E

    2013-12-01

    Chronic obstructive pulmonary disease (COPD) is a common and often progressive inflammatory disease of the airways that is both preventable and treatable. It is well established that those with mild-to-moderate disease severity represent the majority of patients with COPD, yet this subpopulation is relatively under-studied. Because of an insidious pre-clinical phase, COPD is both under-diagnosed and under-treated. Recent studies have confirmed that even patients with mild, grade 1 COPD [i.e. those with a reduced forced expiratory volume in one second (FEV1)/forced vital capacity ratio but normal FEV1], have measurable physiological impairment with increased morbidity and a higher risk of mortality compared with non-smoking healthy controls. Beyond the imperative of smoking cessation-the pivotal intervention in all COPD stages-the role of pharmacotherapy for prevention of disease progression has yet to be established. The main objective of this review is to provide a concise overview of the heterogeneous pathophysiology of COPD with only mild airway obstruction on spirometry and obstacles for early diagnosis. We emphasize that the absence of sufficiently powered trials involving a large number of patients precludes definitive recommendations in support of (or against) long-term pharmacological treatment in mild COPD. Despite these limitations, we present a rationale for earlier pharmacological intervention derived from recent physiological studies performed in symptomatic patients with mild COPD.

  17. Delayed epidural hematoma after mild head injury

    Directory of Open Access Journals (Sweden)

    Radulović Danilo

    2005-01-01

    Full Text Available Background. Traumatic delayed epidural hematoma (DEH can be defined as insignificant or not seen on the initial CT scan performed after a trauma but seen on the subsequent CT scan as a “massive” epidural bleeding. Case report. We presented two cases of traumatic DEH after mild head injury. Both patients were conscious and without neurological deficit on the admission. Initial CT scan did not reveal intracranial hematoma. Repeated CT scan, that was performed after neurological deterioration, revealed epidural hematoma in both cases. The patients were operated with a favorable surgical outcome. Conclusion. Traumatic DEH could occur in the patients with head injuries who were conscious on the admission with a normal initial CT scan finding. Early detection of DEH and an urgent surgical evacuation were essential for a good outcome.

  18. Mild cognitive impairment in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Shu-hua LI

    2016-06-01

    Full Text Available Cognitive dysfunction is common non-motor symptom (NMS in Parkinson's disease (PD, which affects the patients' quality of life and increases the burden of caregivers. Cognitive dysfunction in PD can be mild cognitive impairment (MCI or dementia. MCI presents in the early stage of PD and the incidence rate is increasing with the disease progression. In some cases it can advance to dementia. The diagnosis of MCI in PD includes inclusion criteria, exclusion criteria and damage level evaluation. Non-pharmacological therapy, such as exercise and cognitive behavior therapy (CBT can improve the symptoms of MCI in PD, while the pharmacological treatment remains to be further studied. DOI: 10.3969/j.issn.1672-6731.2016.06.002

  19. A mouse model of human repetitive mild traumatic brain injury

    OpenAIRE

    Kane, Michael J; Pérez, Mariana Angoa; Briggs, Denise I.; Viano, David C.; Kreipke, Christian W.; Kuhn, Donald M.

    2011-01-01

    A novel method for the study of repetitive mild traumatic brain injury (rmTBI) that models the most common form of head injury in humans is presented. Existing animal models of TBI impart focal, severe damage unlike that seen in repeated and mild concussive injuries, and few are configured for repetitive application. Our model is a modification of the Marmarou weight drop method and allows repeated head impacts to lightly anesthetized mice. A key facet of this method is the delivery of an imp...

  20. Perforated Hepatic Hydatid Cyst into the Peritoneum with Mild Symptoms

    Directory of Open Access Journals (Sweden)

    A. Dirican

    2008-11-01

    Full Text Available Rupture into the abdominal cavity is a rare but serious complication of hydatid disease that necessitates emergency surgical intervention. We present herein a case with mild abdominal symptoms due to hydatid cyst rupture into the peritoneum after trauma. A 24-year-old man was admitted to the emergency room with mild abdominal pain. His symptoms had started after a fall four days earlier. Ultrasonography and computed tomography showed cystic lesions in the liver and peritoneum with intraabdominal free fluid. He was treated surgically with partial cystectomy and falciformoplasty. Postoperative albendazole therapy was given for two months. There was not recurrence four months postoperatively at control computed tomography.

  1. Toyota hybrid synergy drive

    Energy Technology Data Exchange (ETDEWEB)

    Gautschi, H.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Hannes Gautschi, director of service and training at the Toyota company in Switzerland, takes a look at Toyota's hybrid drive vehicles. The construction of the vehicles and their combined combustion engines and electric generators and drives is presented and the combined operation of these components is described. Braking and energy recovery are discussed. Figures on the performance, fuel consumption and CO{sub 2} output of the hybrid vehicles are compared with those of conventional vehicles.

  2. Toyota hybrid synergy drive

    Energy Technology Data Exchange (ETDEWEB)

    Gautschi, H.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Hannes Gautschi, director of service and training at the Toyota company in Switzerland, takes a look at Toyota's hybrid drive vehicles. The construction of the vehicles and their combined combustion engines and electric generators and drives is presented and the combined operation of these components is described. Braking and energy recovery are discussed. Figures on the performance, fuel consumption and CO{sub 2} output of the hybrid vehicles are compared with those of conventional vehicles.

  3. Hybrid vehicle potential assessment. Volume 7. Hybrid vehicle review

    Energy Technology Data Exchange (ETDEWEB)

    Leschly, K.O.

    1979-09-30

    Review of hybrid vehicles (HVs) built during the past ten years or planned to be built in the near future is presented. An attempt is made to classify and analyze these vehicles to get an overall picture of their key characteristics. The review includes on-road hybrid passenger cars, trucks, vans, and buses.

  4. Hybrid vehicle potential assessment. Volume 7: Hybrid vehicle review

    Science.gov (United States)

    Leschly, K. O.

    1979-01-01

    Review of hybrid vehicles built during the past ten years or planned to be built in the near future is presented. An attempt is made to classify and analyze these vehicles to get an overall picture of their key characteristics. The review includes onroad hybrid passenger cars, trucks, vans, and buses.

  5. Sliding Wear Properties of Hybrid Aluminium Composite Reinforced by Particles of Palm Shell Activated Carbon and Slag

    Directory of Open Access Journals (Sweden)

    Zamri Yusoff

    2011-09-01

    Full Text Available In present work, dry sliding wear tests were conducted on hybrid composite reinforced with natural carbon based particles such as palm shell activated carbon (PSAC and slag. Hybrid composites containing 5 -20 wt.% of both reinforcements with average particles sizes about 125μm were prepared by conventional powder metallurgy technique, which involves the steps of mixing, compacting and sintering. Dry sliding experiments were conducted in air at room temperature using a pin-on-disc self-built attach to polisher machine. The disc which acted as the mating surface material was made of mild steel (120 HV cut from commercial mild steel sheet (2 mm thickness into 100mm diameter. The influence of the applied load was investigated under a constant sliding velocity of 0.1m/s with the applied loads at 3N, 11N and 51N. The contribution of the reinforcement content and the applied load as well as the sliding distance on the wear process and the wear rate have been investigated. The contribution of synergic factors such as applied load, sliding distance and reinforcement content (wt.% have been studied using analysis of variance (ANOVA. All synergic factors contribute to the wear process of all tested composites. Among synergic factors, the applied load is the highest contribution to wear process on both composites (Al/PSAC and Al/Slag and hybrid composite. The degree of improvement of wear resistance of hybrid composite is strongly dependent on the reinforcement content.

  6. Numerical Magnitude Processing in Children with Mild Intellectual Disabilities

    Science.gov (United States)

    Brankaer, Carmen; Ghesquiere, Pol; De Smedt, Bert

    2011-01-01

    The present study investigated numerical magnitude processing in children with mild intellectual disabilities (MID) and examined whether these children have difficulties in the ability to represent numerical magnitudes and/or difficulties in the ability to access numerical magnitudes from formal symbols. We compared the performance of 26 children…

  7. Heterogenous mechanisms of mild cognitive impairment in Parkinson's disease.

    Science.gov (United States)

    Jellinger, Kurt

    2012-03-01

    Mild cognitive impairment in Parkinson disease (PD-MCI) shows heterogeneity in the clinical presentation, neuropsychology, neuroimaging, and neuropathology, suggesting abnormal metabolic network activities involving several cortical and subcortical systems. Prospective studies using specific biomarkers, including amyloid imaging and CSF biomarkers are important for the diagnosis and prognostic assessment of early cognitive deficits in PD patients.

  8. Corrosion Inhibition Property of Some 1, 3, 4- Thiadiazolines on Mild Steel in Acidic Medium

    Directory of Open Access Journals (Sweden)

    A. Shamitha Begum

    2010-01-01

    Full Text Available The present work deals with the corrosion behavior of mild steel in acidic medium. The inhibitive effect of substituted 1, 3, 4-Thiadiazol-2-amines on the corrosion of mild steel in 1 M H2SO4 has been studied by weight loss and electrochemical methods. The electrochemical parameters for mild steel in acidic solution with and without inhibitor were calculated. The effect of temperature on the corrosion rate, activation energy and free energy of adsorption were also calculated. The synergistic effect has been studied by weight loss and electrochemical methods. The electrochemical parameters for mild steel in acidic solution were also calculated.

  9. Expanding Discourse Repertoires with Hybridity

    Science.gov (United States)

    Kelly, Gregory J.

    2012-01-01

    In "Hybrid discourse practice and science learning" Kamberelis and Wehunt present a theoretically rich argument about the potential of hybrid discourses for science learning. These discourses draw from different forms of "talk, social practice, and material practices" to create interactions that are "intertextually complex" and "interactionally…

  10. Hybridity in Embedded Computing Systems

    Institute of Scientific and Technical Information of China (English)

    虞慧群; 孙永强

    1996-01-01

    An embedded system is a system that computer is used as a component in a larger device.In this paper,we study hybridity in embedded systems and present an interval based temporal logic to express and reason about hybrid properties of such kind of systems.

  11. Should we treat mild subclinical/mild hyperthyroidism? No.

    Science.gov (United States)

    Vanderpump, Mark P J

    2011-08-01

    The management of a patient with subclinical hyperthyroidism or mild thyroid over-activity is controversial. Subclinical hyperthyroidism is defined as a serum thyrotrophin (TSH) below the reference range but a normal thyroxine (T4) and triiodothyronine (T3) level in a patient who is either asymptomatic or has only non-specific symptoms. Epidemiological studies report an overall prevalence of approximately 3%, with men and women over 65 years and those in iodine deficient regions having the highest prevalence. Approximately 50% of subjects are taking levothyroxine. The aetiology for those with endogenous subclinical hyperthyroidism is Graves' disease, toxic nodular goitre or rarely a solitary toxic adenoma or thyroiditis. Non-thyroidal illness is an important cause of false positive low serum TSH test results. Subjects with low but detectable serum TSH values (0.1-0.4 mU/L) usually recover spontaneously when re-tested. It has been estimated that in those with an undetectable serum TSH (hyperthyroidism occurs at a rate up to 5% per year. Advocates of intervening for subclinical hyperthyroidism argue that early treatment might reduce mortality, prevent the later development of atrial fibrillation, osteoporotic fractures, and overt hyperthyroidism but data supporting improvement in outcomes are sparse. No appropriately powered prospective, randomised, controlled, double-blinded trial of intervention for subclinical hyperthyroidism exists. For the vast majority of patients adopting a "wait and see" policy rather than intervention may avoid unnecessary treatment or the potential for harm. Any potential benefits of therapy in subclinical hyperthyroidism must be weighed against the significant morbidity associated with the treatment of hyperthyroidism.

  12. Heterogeneity in executive impairment in patients with very mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Stokholm, Jette; Vogel, Asmus; Gade, Anders;

    2006-01-01

    The presence of executive impairment in mild Alzheimer's disease (AD) has primarily been demonstrated by means of group comparison. Whether executive dysfunction is a common feature of mild AD or only present in a subgroup of patients remains unclear. The aim of this study was to describe...

  13. Implementing a Problem-Solving Intervention with Students with Mild to Moderate Disabilities

    Science.gov (United States)

    Cote, Debra L.

    2011-01-01

    Students with mild and moderate disabilities need to be skillful at problem solving. This article provides an overview of a problem-solving intervention designed to teach students with mild and moderate disabilities the skills of problem solving. An explanation of the assessments, materials, instructional outline, and methods is presented.…

  14. Modeling and analysis using hybrid Petri nets

    CERN Document Server

    Ghomri, Latéfa

    2007-01-01

    This paper is devoted to the use of hybrid Petri nets (PNs) for modeling and control of hybrid dynamic systems (HDS). Modeling, analysis and control of HDS attract ever more of researchers' attention and several works have been devoted to these topics. We consider in this paper the extensions of the PN formalism (initially conceived for modeling and analysis of discrete event systems) in the direction of hybrid modeling. We present, first, the continuous PN models. These models are obtained from discrete PNs by the fluidification of the markings. They constitute the first steps in the extension of PNs toward hybrid modeling. Then, we present two hybrid PN models, which differ in the class of HDS they can deal with. The first one is used for deterministic HDS modeling, whereas the second one can deal with HDS with nondeterministic behavior. Keywords: Hybrid dynamic systems; D-elementary hybrid Petri nets; Hybrid automata; Controller synthesis

  15. Dynamical investigation of macromolecular hybridization bioassays

    CERN Document Server

    Bittner, R; Wixforth, A

    2002-01-01

    A novel sensoric technique for the dynamical in situ investigation of a hybridization bio assay is presented, which utilizes a metal bead labeling method. Therein, hybridization results in an increased metal coverage on parts of a substrate, where it takes place. Our sensing principle relies on the measurement of the radio frequency impedance of the hybridization spots. We propose several examples for sensor devices.

  16. A boy with mild mental retardation, mild sensorineural hearing loss and mild facial dysmorphism caused by a 19p13.2 deletion: a case report and review of the literature.

    Science.gov (United States)

    Schwemmle, Cornelia; Rost, Imma; Spranger, Stephanie; Jungheim, Michael; Ptok, Martin

    2014-07-01

    The investigation of patients with congenital anomalies and/or intellectual disability with modern genetic methods allows the recognition of an increasing number of cases with these chromosomal rearrangements. Here, we present a mildly mentally retarded boy with mild facial dysmorphism, language development delay, mild sensorineural hearing loss due to a deletion of 1,14 Mb on chromosome 19p 13.2. The deletion was de novo and familial history negative for this disorder. To our knowledge this is the first description of a patient with symptoms mentioned above associated with a 19p13.2-p13.2 deletion. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. Regional analysis of the magnetization transfer ratio of the brain in mild Alzheimer disease and amnestic mild cognitive impairment.

    Science.gov (United States)

    Mascalchi, M; Ginestroni, A; Bessi, V; Toschi, N; Padiglioni, S; Ciulli, S; Tessa, C; Giannelli, M; Bracco, L; Diciotti, S

    2013-01-01

    Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio in the hippocampus of patients with Alzheimer disease. We investigated with whole-brain voxelwise analysis the regional changes of the magnetization transfer ratio in patients with mild Alzheimer disease and patients with amnestic mild cognitive impairment. Twenty patients with mild Alzheimer disease, 27 patients with amnestic mild cognitive impairment, and 30 healthy elderly control subjects were examined with high-resolution T1WI and 3-mm-thick magnetization transfer images. Whole-brain voxelwise analysis of magnetization transfer ratio maps was performed by use of Statistical Parametric Mapping 8 software and was supplemented by the analysis of the magnetization transfer ratio in FreeSurfer parcellation-derived VOIs. Voxelwise analysis showed 2 clusters of significantly decreased magnetization transfer ratio in the left hippocampus and amygdala and in the left posterior mesial temporal cortex (fusiform gyrus) of patients with Alzheimer disease as compared with control subjects but no difference between patients with amnestic mild cognitive impairment and either patients with Alzheimer disease or control subjects. VOI analysis showed that the magnetization transfer ratio in the hippocampus and amygdala was significantly lower (bilaterally) in patients with Alzheimer disease when compared with control subjects (ANOVA with Bonferroni correction, at P Alzheimer disease. Support vector machine-based classification demonstrated improved classification performance after inclusion of magnetization transfer ratio-related features, especially between patients with Alzheimer disease versus healthy subjects. Bilateral but asymmetric decrease of magnetization transfer ratio reflecting microstructural changes of the residual GM is present not only in the hippocampus but also in the amygdala in patients with mild Alzheimer disease.

  18. A LINEAR HYBRID MODEL OF MSE AND BEM FOR FLOATING STRUCTURES IN COASTAL ZONES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jun; MIAO Guo-ping

    2006-01-01

    A linear hybrid model of Mild Slope Equation (MSE) and Boundary Element Method (BEM) is developed to study the wave propagation around floating structures in coastal zones. Both the wave refraction under the influence of topography and the wave diffraction by floating structures are considered. Hence, the model provides wave properties around the coastal floating structures of arbitrary shape but also the wave forces on and the hydrodynamic characteristics of the structures. Different approaches are compared to demonstrate the validity of the present hybrid model. Several numerical tests are carried out for the cases of pontoons under different circumstances. The results show that the influence of topography on the hydrodynamic characteristics of floating structures in coastal regions is important and must not be ignored in the most wave period range with practical interests.

  19. Preparation and Characterization of New Geopolymer-Epoxy Resin Hybrid Mortars

    Directory of Open Access Journals (Sweden)

    Raffaele Cioffi

    2013-07-01

    Full Text Available The preparation and characterization of metakaolin-based geopolymer mortars containing an organic epoxy resin are presented here for the first time. The specimens have been prepared by means of an innovative in situ co-reticulation process, in mild conditions, of commercial epoxy based organic resins and geopolymeric slurry. In this way, geopolymer based hybrid mortars characterized by a different content of normalized sand (up to 66% in weight and by a homogeneous dispersion of the organic resin have been obtained. Once hardened, these new materials show improved compressive strength and toughness in respect to both the neat geopolymer and the hybrid pastes since the organic polymer provides a more cohesive microstructure, with a reduced amount of microcracks. The microstructural characterization allows to point out the presence of an Interfacial Transition Zone similar to that observed in cement based mortars and concretes. A correlation between microstructural features and mechanical properties has been studied too.

  20. Activity restriction in mild COPD: a challenging clinical problem

    Directory of Open Access Journals (Sweden)

    O'Donnell DE

    2014-06-01

    Full Text Available Denis E O'Donnell,1 Kevin B Gebke2 1Division of Respiratory and Critical Care Medicine, Respiratory Investigation Unit, Queen's University and Kingston General Hospital, Kingston, ON, Canada; 2Primary Care Sports Medicine Program, Indiana University School of Medicine, Indianapolis, IN, USA Abstract: Dyspnea, exercise intolerance, and activity restriction are already apparent in mild chronic obstructive pulmonary disease (COPD. However, patients may not seek medical help until their symptoms become troublesome and persistent and significant respiratory impairment is already present; as a consequence, further sustained physical inactivity may contribute to disease progression. Ventilatory and gas exchange impairment, cardiac dysfunction, and skeletal muscle dysfunction are present to a variable degree in patients with mild COPD, and collectively may contribute to exercise intolerance. As such, there is increasing interest in evaluating exercise tolerance and physical activity in symptomatic patients with COPD who have mild airway obstruction, as defined by spirometry. Simple questionnaires, eg, the modified British Medical Research Council dyspnea scale and the COPD Assessment Test, or exercise tests, eg, the 6-minute or incremental and endurance exercise tests can be used to assess exercise performance and functional status. Pedometers and accelerometers are used to evaluate physical activity, and endurance tests (cycle or treadmill using constant work rate protocols are used to assess the effects of interventions such as pulmonary rehabilitation. In addition, alternative outcome measurements, such as tests of small airway dysfunction and laboratory-based exercise tests, are used to measure the extent of physiological impairment in individuals with persistent dyspnea. This review describes the mechanisms of exercise limitation in patients with mild COPD and the interventions that can potentially improve exercise tolerance. Also discussed are the

  1. Multifunctional Graphene/Platinum/Nafion Hybrids via Ice Templating

    KAUST Repository

    Estevez, Luis

    2011-04-27

    We report the synthesis of multifunctional hybrids in both films and bulk form, combining electrical and ionic conductivity with porosity and catalytic activity. The hybrids are synthesized by a two-step process: (a) ice templation of an aqueous suspension comprised of Nafion, graphite oxide, and chloroplatinic acid to form a microcellular porous network and (b) mild reduction in hydrazine or monosodium citrate which leads to graphene-supported Pt nanoparticles on a Nafion scaffold. © 2011 American Chemical Society.

  2. Postpartum Depression After Mild and Severe Preeclampsia

    NARCIS (Netherlands)

    Hoedjes, Meeke; Berks, Durk; Vogel, Ineke; Franx, Arie; Bangma, Meike; Darlington, Anne-Sophie E.; Visser, Willy; Duvekot, Johannes J.; Habbema, J. Dik F.; Steegers, Eric A. P.; Raat, Hein

    2011-01-01

    Objective: To describe the prevalence of postpartum depressive symptoms after preeclampsia, to assess the extent to which the prevalence of postpartum depressive symptoms differs after mild and severe preeclampsia, and to investigate which factors contribute to such differences. Methods: Women

  3. Nonsurgical interventions after mild traumatic brain injury

    DEFF Research Database (Denmark)

    Nygren-de Boussard, Catharina; Holm, Lena W; Cancelliere, Carol;

    2014-01-01

    OBJECTIVE: To synthesize the best available evidence regarding the impact of nonsurgical interventions on persistent symptoms after mild traumatic brain injury (MTBI). DATA SOURCES: MEDLINE and other databases were searched (2001-2012) with terms including "rehabilitation." Inclusion criteria wer...

  4. Accelerated Senescence and Enhanced Disease Resistance in Hybrid Chlorosis Lines Derived from Interspecific Crosses between Tetraploid Wheat and Aegilops tauschii

    OpenAIRE

    Hiroki Nakano; Nobuyuki Mizuno; Yukio Tosa; Kentaro Yoshida; Pyoyun Park; Shigeo Takumi

    2015-01-01

    Hybrid chlorosis, a type of hybrid incompatibility, has frequently been reported in inter- and intraspecific crosses of allopolyploid wheat. In a previous study, we reported some types of growth abnormalities such as hybrid necrosis and observed hybrid chlorosis with mild or severe abnormalities in wheat triploids obtained in crosses between tetraploid wheat cultivar Langdon and four Ae. tauschii accessions and in their derived synthetic hexaploids. However, the molecular mechanisms underlyin...

  5. Hybrid microelectronic technology

    Science.gov (United States)

    Moran, P.

    Various areas of hybrid microelectronic technology are discussed. The topics addressed include: basic thick film processing, thick film pastes and substrates, add-on components and attachment methods, thin film processing, and design of thick film hybrid circuits. Also considered are: packaging hybrid circuits, automating the production of hybrid circuits, application of hybrid techniques, customer's view of hybrid technology, and quality control and assurance in hybrid circuit production.

  6. Accelerated senescence and enhanced disease resistance in hybrid chlorosis lines derived from interspecific crosses between tetraploid wheat and Aegilops tauschii.

    Science.gov (United States)

    Nakano, Hiroki; Mizuno, Nobuyuki; Tosa, Yukio; Yoshida, Kentaro; Park, Pyoyun; Takumi, Shigeo

    2015-01-01

    Hybrid chlorosis, a type of hybrid incompatibility, has frequently been reported in inter- and intraspecific crosses of allopolyploid wheat. In a previous study, we reported some types of growth abnormalities such as hybrid necrosis and observed hybrid chlorosis with mild or severe abnormalities in wheat triploids obtained in crosses between tetraploid wheat cultivar Langdon and four Ae. tauschii accessions and in their derived synthetic hexaploids. However, the molecular mechanisms underlying hybrid chlorosis are not well understood. Here, we compared cytology and gene expression in leaves to characterize the abnormal growth in wheat synthetics showing mild and severe chlorosis. In addition, we compared disease resistance to wheat blast fungus. In total 55 and 105 genes related to carbohydrate metabolism and 53 and 89 genes for defense responses were markedly up-regulated in the mild and severe chlorosis lines, respectively. Abnormal chloroplasts formed in the mesophyll cells before the leaves yellowed in the hybrid chlorosis lines. The plants with mild chlorosis showed increased resistance to wheat blast and powdery mildew fungi, although significant differences only in two, third internode length and maturation time, out of the examined agricultural traits were found between the wild type and plants showing mild chlorosis. These observations suggest that senescence might be accelerated in hybrid chlorosis lines of wheat synthetics. Moreover, in wheat synthetics showing mild chlorosis, the negative effects on biomass can be minimized, and they may show substantial fitness under pathogen-polluted conditions.

  7. Accelerated senescence and enhanced disease resistance in hybrid chlorosis lines derived from interspecific crosses between tetraploid wheat and Aegilops tauschii.

    Directory of Open Access Journals (Sweden)

    Hiroki Nakano

    Full Text Available Hybrid chlorosis, a type of hybrid incompatibility, has frequently been reported in inter- and intraspecific crosses of allopolyploid wheat. In a previous study, we reported some types of growth abnormalities such as hybrid necrosis and observed hybrid chlorosis with mild or severe abnormalities in wheat triploids obtained in crosses between tetraploid wheat cultivar Langdon and four Ae. tauschii accessions and in their derived synthetic hexaploids. However, the molecular mechanisms underlying hybrid chlorosis are not well understood. Here, we compared cytology and gene expression in leaves to characterize the abnormal growth in wheat synthetics showing mild and severe chlorosis. In addition, we compared disease resistance to wheat blast fungus. In total 55 and 105 genes related to carbohydrate metabolism and 53 and 89 genes for defense responses were markedly up-regulated in the mild and severe chlorosis lines, respectively. Abnormal chloroplasts formed in the mesophyll cells before the leaves yellowed in the hybrid chlorosis lines. The plants with mild chlorosis showed increased resistance to wheat blast and powdery mildew fungi, although significant differences only in two, third internode length and maturation time, out of the examined agricultural traits were found between the wild type and plants showing mild chlorosis. These observations suggest that senescence might be accelerated in hybrid chlorosis lines of wheat synthetics. Moreover, in wheat synthetics showing mild chlorosis, the negative effects on biomass can be minimized, and they may show substantial fitness under pathogen-polluted conditions.

  8. Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    Science.gov (United States)

    Torisu, Hiroyuki; Yoshikawa, Yoko; Yamaguchi-Takada, Yui; Yano, Tamami; Sanefuji, Masafumi; Ishizaki, Yoshito; Sawaishi, Yukio; Hara, Toshiro

    2013-05-01

    We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MRI) findings fulfilled all MRI-based criteria for the diagnosis of Alexander disease and revealed mild atrophy of the dorsal pons and medulla oblongata with abnormal intensities. DNA analysis disclosed a novel heterozygous missense mutation (c.1154 C>T, p.S385F) in the glial fibrillary acidic protein gene. At 8 months of age, tonic spasms occurred, and electroencephalography (EEG) revealed hypsarrhythmia. Lamotrigine effectively controlled the infantile spasms and improved the abnormal EEG findings. Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare. This comorbid condition may be associated with the distribution of the brain lesions and the age at onset of Alexander disease.

  9. Hybrid Vehicle Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-06-01

    This report summarizes the activities on the Hybrid Vehicle Program. The program objectives and the vehicle specifications are reviewed. The Hybrid Vehicle has been designed so that maximum use can be made of existing production components with a minimum compromise to program goals. The program status as of the February 9-10 Hardware Test Review is presented, and discussions of the vehicle subsystem, the hybrid propulsion subsystem, the battery subsystem, and the test mule programs are included. Other program aspects included are quality assurance and support equipment. 16 references, 132 figures, 47 tables.

  10. Array-based comparative genomic hybridization facilitates identification of breakpoints of a novel der(1)t(1;18)(p36.3;q23)dn in a child presenting with mental retardation.

    Science.gov (United States)

    Lennon, P A; Cooper, M L; Curtis, M A; Lim, C; Ou, Z; Patel, A; Cheung, S W; Bacino, C A

    2006-06-01

    Monosomy of distal 1p36 represents the most common terminal deletion in humans and results in one of the most frequently diagnosed mental retardation syndromes. This deletion is considered a contiguous gene deletion syndrome, and has been shown to vary in deletion sizes that contribute to the spectrum of phenotypic anomalies seen in patients with monosomy 1p36. We report on an 8-year-old female with characteristics of the monosomy 1p36 syndrome who demonstrated a novel der(1)t(1;18)(p36.3;q23). Initial G-banded karyotype analysis revealed a deleted chromosome 1, with a breakpoint within 1p36.3. Subsequent FISH and array-based comparative genomic hybridization not only confirmed and partially characterized the deletion of chromosome 1p36.3, but also uncovered distal trisomy for 18q23. In this patient, the duplicated 18q23 is translocated onto the deleted 1p36.3 region, suggesting telomere capture. Molecular characterization of this novel der(1)t(1;18)(p36.3;q23), guided by our clinical array-comparative genomic hybridization, demonstrated a 3.2 Mb terminal deletion of chromosome 1p36.3 and a 200 kb duplication of 18q23 onto the deleted 1p36.3, presumably stabilizing the deleted chromosome 1. DNA sequence analysis around the breakpoints demonstrated no homology, and therefore this telomere capture of distal 18q is apparently the result of a non-homologous recombination. Partial trisomy for 18q23 has not been previously reported. The importance of mapping the breakpoints of all balanced and unbalanced translocations found in the clinical laboratory, when phenotypic abnormalities are found, is discussed.

  11. A general purpose characterization system for rooftop hybrid microconcentrators

    Science.gov (United States)

    Middleton, Robert; Jones, Christopher; Thomsen, Elizabeth; Diez, Vicente Munoz; Harvey, J.; Everett, Vernie; Blakers, Andrew

    2014-09-01

    A versatile characterization system for hybrid thermal and photovoltaic solar receivers is presented and demonstrated. The characterization of the thermal loss and effective area of a novel hybrid receiver is presented.

  12. Double hybrid inflation and gravitational waves

    CERN Document Server

    Lazarides, G

    2015-01-01

    A double hybrid inflationary scenario in non-minimal supergravity which can predict values of the tensor-to-scalar ratio up to about 0.05 is presented. Larger values of this ratio would require unacceptably large running of the scalar spectral index. The underlying supersymmetric particle physics model possesses, for the chosen values of the parameters, practically two inflationary paths, the trivial and the semi-shifted one. The trivial path is stabilized by supergravity and supports a first stage of inflation with a limited number of e-foldings. The tensor-to-scalar ratio can become appreciable with the scalar spectral index remaining acceptable, as a result of the competition between the relatively mild supergravity and the strong radiative corrections to the inflationary potential. The additional number of e-foldings required for solving the puzzles of hot big bang cosmology are generated by a second stage of inflation along the semi-shifted path. This is possible only because the semi-shifted path is alm...

  13. Supernumerary ring chromosome 20 characterized by fluorescence in situ hybridization

    NARCIS (Netherlands)

    Van Langen, Irene M.; Otter, Mariëlle A.; Aronson, Daniël C.; Overweg-Plandsoen, W.C.G.; Hennekam, Raoul C.M.; Leschot, Nico J.; Hoovers, Jan M.N.

    1996-01-01

    We report on a boy with mild dysmorphic features and developmental delay, in whom karyotyping showed an additional minute ring chromosome in 60% of metaphases. Fluorescence in situ hybridization (FISH) with a centromere specific probe demonstrated that the ring chromosome contained the centromeric r

  14. Hybrid models for complex fluids

    CERN Document Server

    Tronci, Cesare

    2010-01-01

    This paper formulates a new approach to complex fluid dynamics, which accounts for microscopic statistical effects in the micromotion. While the ordinary fluid variables (mass density and momentum) undergo usual dynamics, the order parameter field is replaced by a statistical distribution on the order parameter space. This distribution depends also on the point in physical space and its dynamics retains the usual fluid transport features while containing the statistical information on the order parameter space. This approach is based on a hybrid moment closure for Yang-Mills Vlasov plasmas, which replaces the usual cold-plasma assumption. After presenting the basic properties of the hybrid closure, such as momentum map features, singular solutions and Casimir invariants, the effect of Yang-Mills fields is considered and a direct application to ferromagnetic fluids is presented. Hybrid models are also formulated for complex fluids with symmetry breaking. For the special case of liquid crystals, a hybrid formul...

  15. Hybrid Gear

    Science.gov (United States)

    Handschuh, Robert F. (Inventor); Roberts, Gary D. (Inventor)

    2016-01-01

    A hybrid gear consisting of metallic outer rim with gear teeth and metallic hub in combination with a composite lay up between the shaft interface (hub) and gear tooth rim is described. The composite lay-up lightens the gear member while having similar torque carrying capability and it attenuates the impact loading driven noise/vibration that is typical in gear systems. The gear has the same operational capability with respect to shaft speed, torque, and temperature as an all-metallic gear as used in aerospace gear design.

  16. Hybrid Qualifications

    DEFF Research Database (Denmark)

    has turned out as a major focus of European education and training policies and certainly is a crucial principle underlying the European Qualifications Framework (EQF). In this context, «hybrid qualifications» (HQ) may be seen as an interesting approach to tackle these challenges as they serve «two...... masters», i.e. by producing skills for the labour market and enabling individuals to progress more or less directly to higher education. The specific focus of this book is placed on conditions, structures and processes which help to combine VET with qualifications leading into higher education...

  17. Numerical Simulation of Non-Linear Wave Propagation in Waters of Mildly Varying Topography with Complicated Boundary

    Institute of Scientific and Technical Information of China (English)

    张洪生; 洪广文; 丁平兴; 曹振轶

    2001-01-01

    In this paper, the characteristics of different forms of mild slope equations for non-linear wave are analyzed, and new non-linear theoretic models for wave propagation are presented, with non-linear terms added to the mild slope equations for non-stationary linear waves and dissipative effects considered. Numerical simulation models are developed of non-linear wave propagation for waters of mildly varying topography with complicated boundary, and the effects are studied of different non-linear corrections on calculation results of extended mild slope equations. Systematical numerical simulation tests show that the present models can effectively reflect non-linear effects.

  18. Present time

    CERN Document Server

    Romero, Gustavo E

    2014-01-01

    The idea of a moving present or `now' seems to form part of our most basic beliefs about reality. Such a present, however, is not reflected in any of our theories of the physical world. I show in this article that presentism, the doctrine that only what is present exists, is in conflict with modern relativistic cosmology and recent advances in neurosciences. I argue for a tenseless view of time, where what we call `the present' is just an emergent secondary quality arising from the interaction of perceiving self-conscious individuals with their environment. I maintain that there is no flow of time, but just an ordered system of events.

  19. Ion-atom hybrid systems

    CERN Document Server

    Willitsch, Stefan

    2014-01-01

    The study of interactions between simultaneously trapped cold ions and atoms has emerged as a new research direction in recent years. The development of ion-atom hybrid experiments has paved the way for investigating elastic, inelastic and reactive collisions between these species at very low temperatures, for exploring new cooling mechanisms of ions by atoms and for implementing new hybrid quantum systems. The present lecture reviews experimental methods, recent results and upcoming developments in this emerging field.

  20. Wankel engine for hybrid powertrain

    Energy Technology Data Exchange (ETDEWEB)

    Butti, A. [Univ. of Florence (Italy); Site, V.D.

    1995-12-31

    The Wankel engine is suited to be used to drive hybrid propulsion systems. The main disadvantage of hybrid propulsion systems is the complexity that causes a high weight and large dimensions. For these reason hybrid systems are more suitable for large size vehicle (buses, vans) rather than for small passenger cars. A considerable reduction of hybrid systems weight and dimensions can be obtained using a Wankel rotary engine instead of a conventional engine. The Wankel engine is light, compact, simple, and produces low noise and low vibrations. Therefore a Wankel engine powered hybrid system is suited to be used on small cars. In this paper a 1,000 kg parallel hybrid car with continuously variable transmission and a 6,000 kg series hybrid minibus both equipped with Wankel engines are considered. The Wankel engine works at steady state to minimize fuel consumption and exhaust emissions. The simulation of the behavior of these two vehicles during a ECE + EUDC test cycle is presented in order to evaluate the performances of the systems.

  1. Fabrication of Hybrid Petroelectric Vehicle

    Directory of Open Access Journals (Sweden)

    G. Adinarayana

    2014-10-01

    Full Text Available In automobile sector, the need for alternative fuel as a replacement of conventional fossil fuel, due to its depletion and amount of emission has given way for new technologies like Fuel cells vehicles, Electric vehicles. Still a lot of advancement has to take place in these technologies for commercialization. The gap between the current fossil fuel technology and zero emission vehicles can be bridged by hybrid technology. Hybrid vehicles are those which can run on two or more powering sources/fuels. Feasibility of this technology is been proved in four wheelers and automobile giants like Toyota, Honda, and Hyundai have launched successful vehicles like Toyota prius, Honda insight etc. This technology maximizes the advantages of the two fuels and minimizes the disadvantages of the same. The best preferred hybrid pair is electric and fossil fuel. This increases the mileage of the vehicle twice the existing and also reduces the emission to half. At present, we like to explore the hybrid technology in the two wheeler sector and its feasibility on road. This paper deals with an attempt to make a hybrid with electric start and petrol run. Further a design of basic hybrid elements like motor, battery, and engine. As on today, hybrid products are one of the best solutions for all pollution hazards at a fairly nominal price. An investment within the means of a common man that guarantees a better environment to live in.

  2. Advances in the study of hybrid finite elements

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Some new concepts and research progress in hybrid finite elements advanced in recent years are in troduced. On the basis of incompatible energy consistency analysis, the optimal condition of hybrid elements is derived and the formulation for fulfilling this condition is given. A post-processing penalty equilibrium optimization technique of hybrid element is presented to create high quality hybrid model. For incompressible problems, a method of deviatoric hybrid element is proposed and unification of computation between compressible and incompressible media is achieved.

  3. Hybrid zone and its genetic analysis: implication for conservation

    Institute of Scientific and Technical Information of China (English)

    ZHENGDong; LIUXue-dong; MAJian-zhang

    2003-01-01

    Hybrid zone is a very critical concept within the evolutionary biology, because it would offer us a better insight to understand the evolutionary role of gene flow and hybridization based on the cline model. This minireview presents an expatia-tion of history perspectives and research developments upon basic concepts including hybrid zones, hybridization, hybrid and its the genetic cline model. Moreover, by figuring out the existing problem around the hybrids within conservative theory and prac-tices, it suggests that the theory of hybrid zone be introduced into conservation biology and it would be provide a broader and more open theoretical background for conservative research and practices.

  4. [Mild head injuries in the elderly].

    Science.gov (United States)

    Thaler, Heinrich W; Jung-Schmidsfeld, Jochen; Pienaar, Simon

    2017-07-01

    In the elderly, particularly those over 80 years old, head injuries often occur as a result of falls. The majority suffer from mild head injury. After clarification of the initial symptoms in these patients, the main aim is to recognize or exclude intracranial injuries (bleeding). Demonstration of intracranial bleeding is possible with cranial computed tomography (CCT), which in contrast to magnetic resonance imaging (MRI) can be quickly carried out in most cases; however, most patients with mild head injury show no intracranial bleeding. The performance of CCT and the often necessary hospital admission place a severe physical and psychological burden on the elderly. The plasma parameter S100B, combined with the clinical findings, is a valuable instrument for decision making in the management of elderly patients with mild head injury.

  5. Intuitionistic hybrid logic

    DEFF Research Database (Denmark)

    Braüner, Torben

    2011-01-01

    Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area.......Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area....

  6. Continuity Controlled Hybrid Automata

    OpenAIRE

    Bergstra, J. A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of hybrid automata as timed transition systems. We also relate the synchronized product operator on hybrid automata to the parallel composition operator of the process algebra. It turns out that the f...

  7. Neuropsychological function following mild exposure to pentaborane

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.P.; Silverman, J.J.; Garrettson, L.K.; Schulz, C.; Hamer, R.M.

    1984-01-01

    Neuropsychological tests and self-report personality inventories were administered to 14 workers and rescue squad personnel approximately 2 months following mild exposure to pentaborane, a highly toxic volatile liquid boron hydride. Performance decrements were evident on 5 of 11 neuropsychological tests, including Block Design and measures of sustained attention and recent memory. Neuropsychological deficits were not related to emotional changes reported on the Hopkins Symptom Checklist nor to the presence of CT scan abnormality. These results indicate mild residual brain dysfunction following pentaborane intoxication, including possible dysfunction in subcortical regions mediating memory processes and in cortical areas mediating visuo-spatial abilities.

  8. Social participation in home-living patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Sørensen, Lisbeth Villemoes; Waldorff, Frans Boch; Waldemar, Gunhild

    2007-01-01

    The purpose of this study was to investigate social participation in home-living patients with mild Alzheimer's disease (AD) and to identify predictors for low social participation. The study was based on baseline data from 330 home-living patients with mild AD who participated in The Danish...... Alzheimer Intervention Study (DAISY). Proxy-obtained information from primary caregiver assessed patients' social participation. The result showed that low social participation was present in mild AD. Significant independent predictors of low social participation were impairment in activities of daily...

  9. Performance-based testing in mild stroke: identification of unmet opportunity for occupational therapy.

    Science.gov (United States)

    Morrison, M Tracy; Edwards, Dorothy F; Giles, Gordon Muir

    2015-01-01

    Age at first stroke is decreasing, and most strokes are mild to moderate in severity. Executive function (EF) deficits are increasingly recognized in the stroke population, but occupational therapists have not altered their evaluation methods to fully accommodate changing patient needs. We present a hierarchical performance-based testing (PBT) pathway using data to illustrate how PBT could identify patients with mild stroke-related EF deficits in need of occupational therapy intervention. Data suggest that a substantial number of patients with EF deficits after mild stroke could benefit from occupational therapy services.

  10. CATCHY PRESENTATIONS

    DEFF Research Database (Denmark)

    Eriksen, Kaare; Tollestrup, Christian; Ovesen, Nis

    2011-01-01

    An important competence for designers is the ability to communicate and present ideas and proposals for customers, partners, investors and colleagues. The Pecha Kucha principle, developed by Astrid Klein and Mark Dytham, has become a widely used and easy format for the presentation of new concepts...

  11. Design Procedure for Hybrid Ventilation

    DEFF Research Database (Denmark)

    Heiselberg, Per; Tjelflaat, Per Olaf

    Mechanical and natural ventilation systems have developed separately during many years. The natural next step in this development is development of ventilation concepts that utilises and combines the best features from each system into a new type of ventilation system - Hybrid Ventilation....... Buildings with hybrid ventilation often include other sustainable technologies and an energy optimisation requires an integrated approach in the design of the building and its mechanical systems. Therefore, the hybrid ventilation design procedure differs from the design procedure for conventional HVAC....... The first ideas on a design procedure for hybrid ventilation is presented and the different types of design methods, that is needed in different phases of the design process, is discussed....

  12. The Power of Hybridization

    CERN Document Server

    CERN. Geneva

    2011-01-01

    Programming languages always seem to do some things well but not others: Python punts when it comes to user interfaces, Java’s artificial complexity prevents rapid development and produces tangles, and it will be awhile before we see benefits from C++ concurrency work. The cognitive load of languages and their blind spots increases the cost of experimentation, impeding your ability to fail fast and iterate. If you use a single language to solve your problem, you are binding yourself to the worldview limitations and the mistakes made by the creator of that language. Consider increasing your wiggle room by crossing language boundaries, complementing a language that is powerful in one area with a different language powerful in another. Language hybridization can speed development to quickly discover your real problems, giving you more time to fix them. After making a case for hybridizing your thinking in general, I will present a number of simple examples; first showing the benefits of using other languages...

  13. Information Presentation

    Science.gov (United States)

    Holden, Kritina L.; Thompson, Shelby G.; Sandor, Aniko; McCann, Robert S.; Kaiser, Mary K.; Adelstein, Barnard D.; Begault, Durand R.; Beutter, Brent R.; Stone, Leland S.; Godfroy, Martine

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. In addition to addressing display design issues associated with information formatting, style, layout, and interaction, the Information Presentation DRP is also working toward understanding the effects of extreme environments encountered in space travel on information processing. Work is also in progress to refine human factors-based design tools, such as human performance modeling, that will supplement traditional design techniques and help ensure that optimal information design is accomplished in the most cost-efficient manner. The major areas of work, or subtasks, within the Information Presentation DRP for FY10 are: 1) Displays, 2) Controls, 3) Procedures and Fault Management, and 4) Human Performance Modeling. The poster will highlight completed and planned work for each subtask.

  14. Information Presentation

    Science.gov (United States)

    Holden, K.L.; Boyer, J.L.; Sandor, A.; Thompson, S.G.; McCann, R.S.; Begault, D.R.; Adelstein, B.D.; Beutter, B.R.; Stone, L.S.

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center.

  15. Hybrid spacecraft attitude control system

    Directory of Open Access Journals (Sweden)

    Renuganth Varatharajoo

    2016-02-01

    Full Text Available The hybrid subsystem design could be an attractive approach for futurespacecraft to cope with their demands. The idea of combining theconventional Attitude Control System and the Electrical Power System ispresented in this article. The Combined Energy and Attitude ControlSystem (CEACS consisting of a double counter rotating flywheel assemblyis investigated for small satellites in this article. Another hybrid systemincorporating the conventional Attitude Control System into the ThermalControl System forming the Combined Attitude and Thermal ControlSystem (CATCS consisting of a "fluid wheel" and permanent magnets isalso investigated for small satellites herein. The governing equationsdescribing both these novel hybrid subsystems are presented and theironboard architectures are numerically tested. Both the investigated novelhybrid spacecraft subsystems comply with the reference missionrequirements.The hybrid subsystem design could be an attractive approach for futurespacecraft to cope with their demands. The idea of combining theconventional Attitude Control System and the Electrical Power System ispresented in this article. The Combined Energy and Attitude ControlSystem (CEACS consisting of a double counter rotating flywheel assemblyis investigated for small satellites in this article. Another hybrid systemincorporating the conventional Attitude Control System into the ThermalControl System forming the Combined Attitude and Thermal ControlSystem (CATCS consisting of a "fluid wheel" and permanent magnets isalso investigated for small satellites herein. The governing equationsdescribing both these novel hybrid subsystems are presented and theironboard architectures are numerically tested. Both the investigated novelhybrid spacecraft subsystems comply with the reference missionrequirements.

  16. Developmental abilities in children with mild visual impairment

    Directory of Open Access Journals (Sweden)

    Vučinić Vesna

    2012-01-01

    Full Text Available This paper presents the results of analyzing the relation between visual acuity and developmental abilities (perceptive functions, verbal and non-verbal abilities in younger school children. The sample consists of 1165 children from urban, suburban, and rural parts of Belgrade, of both genders, aged between 7.5 and 11. American 'Lighthouse' Optotype was used for screening assessment of visual acuity. Mild visual impairment, i.e. near visual acuity in the better eye ranging from 0.3 to 0.7, was detected in 7.9% of the pupils. ACADIA test of developmental abilities was used for the assessment of developmental abilities. When compared to the examinees with visual acuity in the better eye ranging from 0.3 to 0.7 (mild amblyopia, the examinees with normal visual acuity achieved better results in visuomotor coordination, non-verbal reasoning (Visual Association subtest, and concept formation in non-verbal domain (Sequence and Coding subtest. No significant differences were determined in constructive praxis (Drawing Shapes subtest and representational dimension of a drawing (Drawing subtest. According to the criterion of age standard deviation, a statistically significant difference was determined between the examinees with mild visual impairment and the examinees with normal vision (χ2=13,425, df=2, p=0,001; ρ=0,103, p≤0,000. The results of 24.8% of the examinees with mild visual impairment deviate from age norms in one or two SD (14.9% in one SD, and 9.9% in two SD. In the group of examinees with normal vision 12.5% of the results deviate from age norms in one or two SD (8.7% in one SD, and 3.8% in two SD.

  17. Mild disintegration of green microalgae and macroalgae

    NARCIS (Netherlands)

    Postma, Richard

    2016-01-01

    An increased worldwide protein demand for food and feed and the necessity to release the water soluble proteins in the first stage of the cascade biorefinery require the development of mild protein extraction technologies. Cell disintegration is the first hurdle and is considered as one of the most

  18. Mission Connect Mild TBI Translational Research Consortium

    Science.gov (United States)

    2012-08-01

    Enduring Freedom and BINT is one of the most common causes of mortality. Even mild BIBI may be associated with chronic cognitive and emotional deficits...The development of effective therapies for BIBI requires experimental models that replicate important features of BINT in humans. Currently

  19. Surgical strategy for mild ischemic mitral insufficiency

    Institute of Scientific and Technical Information of China (English)

    GU Cheng-xiong; WEI Hua; YU Yang

    2010-01-01

    @@ To the Editor: We read with the interest the article by FAN Hong-guang and colleagues~1 having obtained outstanding early and long-term clinical outcomes of left ventricular restoration for the patients with postinfarction ventricular aneurysm and low left ventricular ejection fraction (LVEF) of mean 37.7%. We would like to comment on surgical strategy for mild ischemic mitral insufficiency.

  20. Mild hyperthermia influence on Herceptin (R) properties

    NARCIS (Netherlands)

    Escoffre, JM; Deckers, RHR; Sasaki, Noboru; Bos, Clemens; Moonen, Chrit

    2015-01-01

    Background. Mild hyperthermia (mHT) increases the tumor perfusion and vascular permeability, and reduces the interstitial fluid pressure, resulting in better intra-tumoral bioavailability of low molecular weight drugs. This approach is potentially also attractive for delivery of therapeutic macromol

  1. Mission Connect Mild TBI Translational Research Consortium

    Science.gov (United States)

    2013-08-01

    and covered with dental acrylic. Isoflurane was discontinued; rats were connected to the trauma device and subjected to a mild 1.0-atm fluid-percussion...return of consciousness in the rat.39,40 Comparison with sham-treated rats allows extrapolating the effects of anesthesia and handling alone; sham

  2. Learning Strategies for Adolescents with Mild Disabilities

    Science.gov (United States)

    Conderman, Greg; Koman, Kara; Schibelka, Mary; Higgin, Karen; Cooper, Cody; Butler, Jordyn

    2013-01-01

    Learning strategy instruction is an evidence-based practice for teaching adolescents with mild disabilities. However, researchers have not developed strategies for every content area or skill. Therefore, teachers need to be able develop strategies based on the needs of their students. This article reviews the process for developing and teaching…

  3. Postpartum Depression After Mild and Severe Preeclampsia

    NARCIS (Netherlands)

    Hoedjes, Meeke; Berks, Durk; Vogel, Ineke; Franx, Arie; Bangma, Meike; Darlington, Anne-Sophie E.; Visser, Willy; Duvekot, Johannes J.; Habbema, J. Dik F.; Steegers, Eric A. P.; Raat, Hein

    2011-01-01

    Objective: To describe the prevalence of postpartum depressive symptoms after preeclampsia, to assess the extent to which the prevalence of postpartum depressive symptoms differs after mild and severe preeclampsia, and to investigate which factors contribute to such differences. Methods: Women diagn

  4. Mild Traumatic Brain Injury – Case Report

    Directory of Open Access Journals (Sweden)

    2015-06-01

    Full Text Available A mild traumatic brain injury or a concussion represents the majority of all traumatic brain injuries. The consequences show on physical, cognitive, and emotional functioning and even though the injury classifies as mild, it can have a significant effect on a patient, patient’s family and their quality of life. Defects are often overlooked as objective clinical methods are lacking. Neuropsychological evaluation can aid in appraisal of the defect magnitude and determine factors that influence the outcome of the injured. The following case report addresses the importance of neuropsychological evaluation in treating cognitive defects along with the Cognitive Behavioral therapy approach toward emotional and behavioral disorders treatment in mild traumatic brain injury. It has been shown how important it is to find possible causes for slow recovery. The annuity tendencies have been noted as an important factor for prolongation of the post-concussion syndrome. We can detect the symptom simulation with appropriate psychological instruments. Described is a case of 38-year-old man who suffered a mild traumatic brain injury.

  5. Time estimation in mild Alzheimer's disease patients

    Directory of Open Access Journals (Sweden)

    Nichelli Paolo

    2009-07-01

    Full Text Available Abstract Background Time information processing relies on memory, which greatly supports the operations of hypothetical internal timekeepers. Scalar Expectancy Theory (SET postulates the existence of a memory component that is functionally separated from an internal clock and other processing stages. SET has devised several experimental procedures to map these cognitive stages onto cerebral regions and neurotransmitter systems. One of these, the time bisection procedure, has provided support for a dissociation between the clock stage, controlled by dopaminergic systems, and the memory stage, mainly supported by cholinergic neuronal networks. This study aimed at linking the specific memory processes predicted by SET to brain mechanisms, by submitting time bisection tasks to patients with probable Alzheimer's disease (AD, that are known to present substantial degeneration of the fronto-temporal regions underpinning memory. Methods Twelve mild AD patients were required to make temporal judgments about intervals either ranging from 100 to 600 ms (short time bisection task or from 1000 to 3000 ms (long time bisection task. Their performance was compared with that of a group of aged-matched control participants and a group of young control subjects. Results Long time bisection scores of AD patients were not significantly different from those of the two control groups. In contrast, AD patients showed increased variability (as indexed by increased WR values in timing millisecond durations and a generalized inconsistency of responses over the same interval in both the short and long bisection tasks. A similar, though milder, decreased millisecond interval sensitivity was found for elderly subjects. Conclusion The present results, that are consistent with those of previous timing studies in AD, are interpreted within the SET framework as not selectively dependent on working or reference memory disruptions but as possibly due to distortions in different

  6. Voting Present

    Directory of Open Access Journals (Sweden)

    James Lo

    2013-12-01

    Full Text Available During his time as a state senator in Illinois, Barack Obama voted “Present” 129 times, a deliberate act of nonvoting that subsequently became an important campaign issue during the 2008 presidential elections. In this article, I examine the use of Present votes in the Illinois state senate. I find evidence that Present votes can largely be characterized as protest votes used as a legislative tool by the minority party. Incorporating information from Present votes into a Bayesian polytomous item-response model, I find that this information increases the efficiency of ideal point estimates by approximately 35%. There is little evidence of significant moderation by Obama when Present votes are accounted for, though my results suggest that Obama’s voting record may have moderated significantly before his subsequent election to the U.S. Senate. My results also suggest that because legislative nonvoting may occur for a variety of reasons, naive inclusion of nonvoting behavior into vote choice models may lead to biased results.

  7. Hybrid synchronization of hyperchaotic Lu system

    Indian Academy of Sciences (India)

    K Sebastian Sudheer; M Sabir

    2009-10-01

    In this paper, we study the hybrid synchronization between two identical hyperchaotic Lu systems. Hybrid synchronization of hyperchaotic Lu system is achieved through synchronization of two pairs of states and anti-synchronization of the other two pairs of states. Active controls are designed to achieve hybrid synchronization between drive and response systems using the sum and difference of relevant variables of the chaotic systems. Numerical simulations are presented to evaluate the analysis and effectiveness of the controllers.

  8. Continuity Controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  9. Continuity controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2008-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  10. Technical presentation

    CERN Multimedia

    FI Department

    2008-01-01

    RADIOSPARES, the leading catalogue distributor of components (electronic, electrical, automation, etc.) and industrial supplies will be at CERN on Friday 3 October 2008 (Main Building, Room B, from 9.00 a.m. to 3.00 p.m.) to introduce its new 2008/2009 catalogue. This will be the opportunity for us to present our complete range of products in more detail: 400 000 part numbers available on our web site (Radiospares France, RS International, extended range of components from other manufacturers); our new services: quotations, search for products not included in the catalogue, SBP products (Small Batch Production: packaging in quantities adapted to customers’ requirements); partnership with our focus manufacturers; demonstration of the on-line purchasing tool implemented on our web site in conjunction with CERN. RADIOSPARES will be accompanied by representatives of FLUKE and TYCO ELECTRONICS, who will make presentations, demonstrate materials and answer any technical questio...

  11. Printed hybrid systems

    Science.gov (United States)

    Karioja, Pentti; Mäkinen, Jukka-Tapani; Keränen, Kimmo; Aikio, Janne; Alajoki, Teemu; Jaakola, Tuomo; Koponen, Matti; Keränen, Antti; Heikkinen, Mikko; Tuomikoski, Markus; Suhonen, Riikka; Hakalahti, Leena; Kopola, Pälvi; Hast, Jukka; Liedert, Ralf; Hiltunen, Jussi; Masuda, Noriyuki; Kemppainen, Antti; Rönkä, Kari; Korhonen, Raimo

    2012-04-01

    This paper presents research activities carried out at VTT Technical Research Centre of Finland in the field of hybrid integration of optics, electronics and mechanics. Main focus area in our research is the manufacturing of electronic modules and product structures with printed electronics, film-over-molding and polymer sheet lamination technologies and the goal is in the next generation of smart systems utilizing monolithic polymer packages. The combination of manufacturing technologies such as roll-to-roll -printing, injection molding and traditional component assembly is called Printed Hybrid Systems (PHS). Several demonstrator structures have been made, which show the potential of polymer packaging technology. One demonstrator example is a laminated structure with embedded LED chips. Element thickness is only 0.3mm and the flexible stack of foils can be bent in two directions after assembly process and was shaped curved using heat and pressure. The combination of printed flexible circuit boards and injection molding has also been demonstrated with several functional modules. The demonstrators illustrate the potential of origami electronics, which can be cut and folded to 3D shapes. It shows that several manufacturing process steps can be eliminated by Printed Hybrid Systems technology. The main benefits of this combination are small size, ruggedness and conformality. The devices are ideally suited for medical applications as the sensitive electronic components are well protected inside the plastic and the structures can be cleaned easily due to the fact that they have no joints or seams that can accumulate dirt or bacteria.

  12. Overview Presentation

    Science.gov (United States)

    Lytle, John

    2001-01-01

    This report provides an overview presentation of the 2000 NPSS (Numerical Propulsion System Simulation) Review and Planning Meeting. Topics include: 1) a background of the program; 2) 1999 Industry Feedback; 3) FY00 Status, including resource distribution and major accomplishments; 4) FY01 Major Milestones; and 5) Future direction for the program. Specifically, simulation environment/production software and NPSS CORBA Security Development are discussed.

  13. Cognitive deficits in patients with mild to moderate traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Eliane Correa Miotto

    2010-12-01

    Full Text Available Traumatic brain injury (TBI is one of the most frequent causes of brain damage. Cognitive deficits reported in the literature after moderate to severe TBI include memory, language, executive functions, attention and information processing speed impairments. However, systematic studies on patients with mild TBI are scarce although neuropsychological changes are present. OBJECTIVE: To investigate the cognitive functioning of patients with mild to moderate TBI. METHOD: We evaluated 12 patients with mild to moderate TBI using a comprehensive protocol (PN01 of neuropsychological tests. RESULTS: There were significant deficits of episodic memory including immediate and delayed verbal memory recall, verbal recognition, immediate and delayed visual memory recall, naming, verbal fluency and information processing speed. CONCLUSION: These results emphasize the importance of comprehensive neuropsychological assessments even in cases of mild TBI in order to identify impaired and preserved functions providing adequate managing including rehabilitation programs for each case.

  14. Ophthalmic artery color Doppler ultrasonography in mild-to-moderate preeclampsia

    Energy Technology Data Exchange (ETDEWEB)

    Ayaz, Tunahan; Akansel, Gur. E-mail: gakansel@superonline.com; Hayirlioglu, Alper; Arslan, Arzu; Suer, Necdet; Kuru, Ihsan

    2003-06-01

    Objective: To evaluate the hemodynamic changes in mild-moderate preeclampsia using ophthalmic artery Doppler ultrasonography technique. Methods: Ophthalmic artery pulsatility and resistivity indices were calculated in 30 mild-moderate preeclamptic women and 30 normotensive gravid women of matched gestational age. Student's t-test was performed to test the significance of difference. Results: Both indices of peripheral resistance were found to be significantly lower in the ophthalmic arteries of mild-moderately preeclamptic women than those measured in normotensive gravid women at similar stage of pregnancy. In a small number patients whose disease progressed to severe preeclampsia, both indices increased. Conclusion: In patients with mild-moderate preeclampsia, ophthalmic artery color Doppler ultrasonography detects hemodynamic changes that are not present in normotensive gravid women. Reversal of Doppler patterns in a small number of patients with progressive disease supports the hypotheses suggesting the presence of early vasodilation and late vasospasm in the etiology of preeclampsia.

  15. Tannin bark Melalauca cajuputi powell (gelam) as green corrosion inhibitor of mild steel

    Science.gov (United States)

    Talib, Nur Atiqah Abu; Zakaria, Sarani; Hua, Chia Chin; Othman, Norinsan Kamil

    2014-09-01

    Tannin was extracted from gelam bark and used to produce corrosion inhibitor for mild steel. Tannin was extracted from gelam bark using 70% aqueous acetone for 6 hour. Tannin powder was characterization using fourier transform infrared spectroscopy to analyse chemical component in tannin and Scanning electron microscope (SEM) for tannin physical structure. The tannin effect on the corrosion inhibition of mild steel has been investigated in 1Mol HCl solution for 6 hour followed ASTM. The weight loss method were applied to study the mild steel corrosion behavior in the present and absend of different concentration of tannin (250, 300, 350)ppm. Tannin act good inhibitor as corrosion inhibitor for mild steel in acid medium. Surface morphology of carbon steel with and without inhibitor was investigated by scanning electron microscopy.

  16. Tannin bark Melalauca cajuputi powell (gelam) as green corrosion inhibitor of mild steel

    Energy Technology Data Exchange (ETDEWEB)

    Talib, Nur Atiqah Abu; Zakaria, Sarani; Hua, Chia Chin; Othman, Norinsan Kamil [School of Applied Physic, Faculty Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor (Malaysia)

    2014-09-03

    Tannin was extracted from gelam bark and used to produce corrosion inhibitor for mild steel. Tannin was extracted from gelam bark using 70% aqueous acetone for 6 hour. Tannin powder was characterization using fourier transform infrared spectroscopy to analyse chemical component in tannin and Scanning electron microscope (SEM) for tannin physical structure. The tannin effect on the corrosion inhibition of mild steel has been investigated in 1Mol HCl solution for 6 hour followed ASTM. The weight loss method were applied to study the mild steel corrosion behavior in the present and absend of different concentration of tannin (250, 300, 350)ppm. Tannin act good inhibitor as corrosion inhibitor for mild steel in acid medium. Surface morphology of carbon steel with and without inhibitor was investigated by scanning electron microscopy.

  17. Gender differences in the enhanced vulnerability of BDNF+/- mice to mild stress.

    Science.gov (United States)

    Advani, Tushar; Koek, Wouter; Hensler, Julie G

    2009-06-01

    Two mild stress paradigms were used in the present study: acute (i.e. three injections of saline over 24 h) and subchronic (i.e. single daily injection of saline for 7 d). These mild stress procedures did not alter the behaviour of wild-type mice in the forced swim test. However, male BDNF+/- mice exhibited increased immobility in the forced swim test after mild stress. This genotypic difference in stress responsivity was also evident in plasma corticosterone levels after a single injection of saline. The behaviour of female mice of either genotype was not altered by mild stress, and there was no genotypic difference in the corticosterone response of female mice to a single saline injection. Male BDNF+/- mice should be a useful model in which to examine behavioural and neurochemical consequences of interactions among genetic and environmental factors implicated in stress-related affective disorders, such as major depression.

  18. Approach to the Patient with Mild Crohn's Disease: a 2016 Update.

    Science.gov (United States)

    Scott, Frank I; Lichtenstein, Gary R

    2016-09-01

    Mild Crohn's disease (CD) is classified as those patients who are ambulatory, with disease, where therapy is focused on mucosal healing, the management of mild CD is focused on symptom management, while exposing the individual to minimal therapeutic risks. Budesonide is the most commonly used medication for mild CD given its safety profile. Assessment of inflammatory markers, in concert with computed-tomography (CT) or magnetic resonance (MR) enterographies and endoscopic studies, should be considered in clinical remission to ensure that mucosal inflammation is not present. Endoscopic inflammation can precede clinical recurrence. Individuals with mild CD require routine vaccination, monitoring for iron-deficiency anemia and vitamin D deficiency, and colorectal cancer screening when appropriate.

  19. Homozygous 16p13.11 duplication associated with mild intellectual disability and urinary tract malformations in two siblings born from consanguineous parents.

    Science.gov (United States)

    Houcinat, N; Llanas, B; Moutton, S; Toutain, J; Cailley, D; Arveiler, B; Combe, C; Lacombe, D; Rooryck, C

    2015-11-01

    The use of array-comparative genomic hybridization (array-CGH) in routine clinical work has allowed the identification of many new copy number variations (CNV). The 16p13.11 duplication has been implicated in various congenital anomalies and neurodevelopmental disorders, but it has also been identified in healthy individuals. We report a clinical observation of two brothers from related parents each carrying a homozygous 16p13.11 duplication. The propositus had mild intellectual disability and posterior urethral valves with chronic renal disease. His brother was considered a healthy child with only learning disabilities and poor academic performances. However, a routine medical examination at 25-years-old revealed a mild chronic renal disease and ureteropelvic junction obstruction. Furthermore, the father presented with a unilateral renal agenesis, thus it seemed that a "congenital anomalies of kidney and urinary tract" (CAKUT) phenotype segregated in this family. This may be related to the duplication, but we cannot exclude the involvement of additional genetic or non-genetic factors in the urological phenotype. Several cohort studies showed association between this chromosomal imbalance and different clinical manifestations, but rarely with CAKUT. The duplication reported here was similar to the larger one of 3.4 Mb previously described versus the more common of 1.6 Mb. It encompassed at least 11 known genes, including the five ohnologs previously identified. Our observation, in addition to expanding the clinical spectrum of the duplication provides further support to understanding the underlying pathogenic mechanism.

  20. A child with mild X-linked intellectual disability and a microduplication at Xp22.12 including RPS6KA3.

    Science.gov (United States)

    Tejada, María-Isabel; Martínez-Bouzas, Cristina; García-Ribes, Ainhoa; Larrucea, Susana; Acquadro, Francesco; Cigudosa, Juan-C; Belet, Stefanie; Froyen, Guy; López-Aríztegui, Maria-Asun

    2011-10-01

    Multiplex ligation-dependent probe amplification (MLPA) and array- comparative genomic hybridization analysis have been proven to be useful in the identification of submicroscopic copy-number imbalances in families with nonsyndromic X-linked intellectual disability (NS-XLID). Here we report the first description of a child with mild intellectual disability and a submicroscopic duplication at Xp22.12 identified by MLPA with a P106 MRX kit (MRC-Holland, Amsterdam, Netherlands) and further confirmed and characterized with a custom 244-k oligo-array, fluorescence in situ hybridization, quantitative polymerase chain reaction (qPCR), and immunoblotting. This 1.05-megabase duplication encompasses 7 genes, RPS6KA3 being the only of these genes known to be related to ID. The proband was an 8-year-old boy referred to the genetics unit for psychomotor retardation and learning disabilities. Both maternal brothers also showed learning difficulties and delayed language during childhood in a similar way to the proband. These boys also carried the duplication, as did the healthy mother and grandmother of the proband. The same duplication was also observed in the 5-year-old younger brother who presented with features of developmental delay and learning disabilities during the previous year. Increased RPS6KA3/RSK2 levels were demonstrated in the proband by qPCR and immunoblotting. To our knowledge, this is the first family identified with a submicroscopic duplication including the entire RPS6KA3/RSK2 gene, and our findings suggest that an increased dose of this gene is responsible for a mild form of NS-XLID.

  1. Technical presentation

    CERN Multimedia

    FP Department

    2009-01-01

    07 April 2009 Technical presentation by Leuze Electronics: 14.00 – 15.00, Main Building, Room 61-1-017 (Room A) Photoelectric sensors, data identification and transmission systems, image processing systems. We at Leuze Electronics are "the sensor people": we have been specialising in optoelectronic sensors and safety technology for accident prevention for over 40 years. Our dedicated staff are all highly customer oriented. Customers of Leuze Electronics can always rely on one thing – on us! •\tFounded in 1963 •\t740 employees •\t115 MEUR turnover •\t20 subsidiaries •\t3 production facilities in southern Germany Product groups: •\tPhotoelectric sensors •\tIdentification and measurements •\tSafety devices

  2. Could language deficits really differentiate Mild Cognitive Impairment (MCI) from mild Alzheimer's disease?

    Science.gov (United States)

    Tsantali, E; Economidis, D; Tsolaki, M

    2013-01-01

    Naming abilities seem to be affected in Alzheimer's disease (AD) patients, though MCI individuals tend to exhibit greater impairments in category fluency. In this study we: (1) detect language deficits of amnestic MCIs (aMCIs) and mild AD (mAD) participants and present their language performance (the Boston Diagnostic Aphasia Examination - BDAE scores) according to educational level, (2) study the diagnostic value of language deficits according to the cognitive state of the participants. One hundred nineteen participants, 38 normal controls (NC), 28 aMCIs and 53 mADs, were recruited randomly as outpatients of 2 clinical departments and administered clinical, neuropsychological and neuroimaging assessment. Language abilities were assessed by the adapted Greek edition of the BDAE (2nd edition). Our results indicate that verbal fluency, auditory, reading comprehension and narrative ability are the main language abilities to be affected in mADs, although they are almost intact in NCs and less vulnerable in aMCIs. Narrative ability seems to be significantly impaired in mADs but not so in aMCIs. Six language subtests of the BDAE assess safely the above deficits. This brief version of the BDAE discriminated mADs from the other 2 groups 92.5% of the time, NCs 86.8% and aMCI 67.9% of the time in order to save time and to be accurate in clinical practice. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  3. Consensus of Hybrid Multi-Agent Systems.

    Science.gov (United States)

    Zheng, Yuanshi; Ma, Jingying; Wang, Long

    2017-01-27

    In this brief, we consider the consensus problem of hybrid multiagent systems. First, the hybrid multiagent system is proposed, which is composed of continuous-time and discrete-time dynamic agents. Then, three kinds of consensus protocols are presented for the hybrid multiagent system. The analysis tool developed in this brief is based on the matrix theory and graph theory. With different restrictions of the sampling period, some necessary and sufficient conditions are established for solving the consensus of the hybrid multiagent system. The consensus states are also obtained under different protocols. Finally, simulation examples are provided to demonstrate the effectiveness of our theoretical results.

  4. On Hybrid and mixed finite element methods

    Science.gov (United States)

    Pian, T. H. H.

    1981-01-01

    Three versions of the assumed stress hybrid model in finite element methods and the corresponding variational principles for the formulation are presented. Examples of rank deficiency for stiffness matrices by the hybrid stress model are given and their corresponding kinematic deformation modes are identified. A discussion of the derivation of general semi-Loof elements for plates and shells by the hybrid stress method is given. It is shown that the equilibrium model by Fraeijs de Veubeke can be derived by the approach of the hybrid stress model as a special case of semi-Loof elements.

  5. Hybrid Dynamical Systems Modeling, Stability, and Robustness

    CERN Document Server

    Goebel, Rafal; Teel, Andrew R

    2012-01-01

    Hybrid dynamical systems exhibit continuous and instantaneous changes, having features of continuous-time and discrete-time dynamical systems. Filled with a wealth of examples to illustrate concepts, this book presents a complete theory of robust asymptotic stability for hybrid dynamical systems that is applicable to the design of hybrid control algorithms--algorithms that feature logic, timers, or combinations of digital and analog components. With the tools of modern mathematical analysis, Hybrid Dynamical Systems unifies and generalizes earlier developments in continuous-time and discret

  6. An Extended Mild-Slope Equation

    Institute of Scientific and Technical Information of China (English)

    PAN Junning; HONG Guangwen; ZUO Qihua

    2000-01-01

    On the assumption that the vortex and the vertical velocity component of the current are small, a mild-slope equation for wave propagation on non-uniform flows is deduced from the basic hydrodynamic equations, with the terms of ( h h)2 and /2h h included in the equation. The terms of bottom friction, wind energy input and wave nonlinearity are also introduced into the equation. The wind energy input functions for wind waves and swells are separately considered by adopting Wen′s (1989) empirical formula for wind waves and Snyder′s observation results for swells. Thus, an extended mild-slope equation is obtained, in which the effects of refraction, diffraction, reflection, current, bottom friction, wind energy input and wave nonlinearity are considered synthetically.

  7. Early supported discharge following mild stroke

    DEFF Research Database (Denmark)

    Lou, Stina; Carstensen, Kathrine; Møldrup, Marie;

    2016-01-01

    BACKGROUND: Early supported discharge (ESD) allows mild-to-moderate stroke patients to return home as soon as possible and continue rehabilitation at their own pace in familiar surroundings. Thus, the main responsibility for continued rehabilitation is in the hands of patients and their partners......, who must collaborate to adjust to poststroke everyday life. However, couples' joint experiences of stroke, early discharge and rehabilitation at home remain minimally investigated. AIM: To investigate how mild stroke patients' and their partners' experience and manage everyday life in a context of ESD....... METHODS: We conducted qualitative interviews with a purposive sample of 22 ESD patients and 18 partners. Interviews were conducted 3-6 weeks after stroke, and we used thematic analysis to analyse the data. FINDINGS: The analysis identified three themes. First, 'Home as a healing place' involved...

  8. A mild form of Proteus syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Hauer, M.P.; Allmann, K.H.; Langer, M. [Abteilung Roentgendiagnostik, Radiologische Universitaetsklinik, Albert-Ludwigs-Universitaet Freiburg (Germany); Uhl, M. [Sektion Kinderradiologie, Albert-Ludwigs-Universitaet (Germany); Darge, K. [Radiologische Universitaetsklinik, Abteilung Kinderradiologie, Universitaet Heidelberg (Germany)

    1998-05-01

    Proteus syndrome is a rare congenital hamartomatous syndrome. We report on the clinical and radiological appearances of a boy in order to illustrate the typical signs which include subcutaneous masses, in mild forms partial gigantism of hands and feet, hemihypertrophy, and bony abnormalities. We discuss how to make the definitive diagnosis on the basis of using a known rating scale, important aspects of differential diagnosis and clinical features, and diagnostic management. (orig.) With 3 figs., 1 tab., 14 refs.

  9. Perinatal Risk Factors for Mild Motor Disability

    Science.gov (United States)

    Hands, Beth; Kendall, Garth; Larkin, Dawne; Parker, Helen

    2009-01-01

    The aetiology of mild motor disability (MMD) is a complex issue and as yet is poorly understood. The aim of this study was to identify the prevalence of perinatal risk factors in a cohort of 10-year-old boys and girls with (n = 362) and without (n = 1193) MMD. Among the males with MMD there was a higher prevalence of postpartum haemorrhage,…

  10. Perinatal Risk Factors for Mild Motor Disability

    Science.gov (United States)

    Hands, Beth; Kendall, Garth; Larkin, Dawne; Parker, Helen

    2009-01-01

    The aetiology of mild motor disability (MMD) is a complex issue and as yet is poorly understood. The aim of this study was to identify the prevalence of perinatal risk factors in a cohort of 10-year-old boys and girls with (n = 362) and without (n = 1193) MMD. Among the males with MMD there was a higher prevalence of postpartum haemorrhage,…

  11. Hybrid drives. Competitor or support of internal combustion systems?; Hybridantrieb. Konkurrenz oder Unterstuetzung fuer Verbrennungsmotoren?

    Energy Technology Data Exchange (ETDEWEB)

    Buschmann, G.; Mayr, B.; Knobel, C. [Ingenieurgesellschaft Auto und Verkehr GmbH (IAV), Berlin (Germany); Link, M. [TEMIC Automotive Electric Motors GmbH, Berlin (Germany)

    2005-07-01

    With a hybrid drive the fuel consumption and the emissions of today's Otto and Diesel engines can be improved. Depending on the power of the used electrical motor and the energy storage method, the hybrid drives can be classified in four stages: Micro, mild, basic and fully hybrid drive. Using a Diesel engine in conjunction with a hybrid drive, the best possible fuel consumption is obtained, whereas a hybrid drive connected with an Otto engine the best possible emissions are realized. However, the fuel consumption levels of the different hybrid stages can also be achieved with further developed Diesel and Otto engines, which produces the same costs. The reasons for and against the hybrid drive rather depends on other factors, e.g. image, driving comfort and legal requirements. (orig.)

  12. Mild obstructive sleep apnea: beyond the AHI

    Directory of Open Access Journals (Sweden)

    Lee-Iannotti J

    2014-07-01

    Full Text Available No abstract available. Article truncated at 150 words. A common conundrum faced by sleep medicine practitioners is how to manage the large group of patients with mild sleep apnea. Many patients are referred for sleep evaluation, with symptoms thought to be due to obstructive sleep apnea (OSA. Often polysomnography demonstrates only mild sleep apnea, and the clinician and patient are faced with the dilemma of whether to use continuous positive airway pressure (CPAP therapy or an oral appliance. In making this important decision the clinician incorporates the commonly used definition of mild sleep apnea as an apnea-hypopnea index of between 5 and 14 apneas or hypopneas per hour of sleep. Moderate sleep apnea is defined as 15-29 events per hour, and severe is 30 and above events per hour. These arbitrary thresholds originated in the early 1980s when knowledge of this condition was in its infancy and little was known about the long term health effects. The definition ...

  13. Brain dysfunction in mild to moderate hypoxia.

    Science.gov (United States)

    Gibson, G E; Pulsinelli, W; Blass, J P; Duffy, T E

    1981-06-01

    Hypoxia is commonly invoked to explain alterations in mental function, particularly in patients with cardiac pulmonary failure. The effects of acute graded hypoxia or higher integrative functions are well documented experimentally in man. Hypoxia in experimental animal models demonstrates that the pathophysiology is complex. In mild to moderate hypoxia, in contrast to severe hypoxia and to ischemia, the supply of energy for the brain is not impaired; cerebral levels of adenosine triphosphate (ATP) and adenylate energy charge are normal. In contrast, the turnover of several neurotransmitters is altered by mild hypoxia. For example, acetylcholine synthesis is reduced proportionally to the reduction in carbohydrate oxidation. This relationship holds in vitro and with several in vivo models of hypoxia. Pharmacologic and physiologic studies in man and experimental animals are consistent with acetylcholine having an important role in mediating the cerebral effects of mild hypoxia. These observations raise the possibility that treatments directed to cholinergic or other central neurotransmitter systems may benefit patients with cerebral syndromes secondary to chronic hypoxia.

  14. Hybrid Random Fields

    CERN Document Server

    Freno, Antonino

    2011-01-01

    This book presents an exciting new synthesis of directed and undirected, discrete and continuous graphical models. Combining elements of Bayesian networks and Markov random fields, the newly introduced hybrid random fields are an interesting approach to get the best of both these worlds, with an added promise of modularity and scalability. The authors have written an enjoyable book---rigorous in the treatment of the mathematical background, but also enlivened by interesting and original historical and philosophical perspectives. -- Manfred Jaeger, Aalborg Universitet The book not only marks an

  15. Histopathological placental lesions in mild gestational hyperglycemic and diabetic women

    Directory of Open Access Journals (Sweden)

    Rudge Marilza VC

    2011-08-01

    Full Text Available Abstract Objective To investigate and compare the incidence of histopathological placental lesions in mild gestational hyperglycemia, gestational diabetes and overt diabetes at term and preterm gestation. Research design and methods One-hundred-and-thirty-one placental samples were collected from Diabetes mellitus (DM positive screened patients. Two diagnostic tests, glycemic profile and 100 g oral glucose tolerance test (OGTT in parallel identified 4 groups normoglycemic, mild gestational hyperglycemia (MGH, gestational DM (GDM or overt DM (DM. Placental tissue specimens and sections from 4 groups were obtained by uniform random sampling and stained with hematoxylin-eosin. Results Placentas from MGH group presented 17 types of histopathological change and higher rates of syncytial nodes and endarteritis. GDM placentas presented only nine types of histopathological change, high rates of dysmaturity, low rates of calcification and no syncytial nodes. Overt DM placentas showed 22 types of histopathological change, 21 of which were present in the preterm period. There were histopathological similarities between MGH and DM placentas, but the former exhibited a higher incidence of endarteritis, which has been described as a "post-mortem" phenomenon. Conclusion Our results confirmed that the distinct placental changes associated with DM and MGH depend on gestational period during which the diabetic insult occurs. It may reasonably be inferred that subclinical maternal hyperglycemia during pregnancy, as showed in MGH group, is responsible for increased placental endarteritis, a postmortem lesion in the live fetus.

  16. Hybrid Compounding in New Zealand English

    Science.gov (United States)

    Degani, Marta; Onysko, Alexander

    2010-01-01

    This study investigates hybrid compound formation of Maori and English terms in present day New Zealand English (NZE). On the background of Maori and English language contact, the phenomenon of hybrid compounding emerges as a process that, on the one hand, symbolizes the vitality of the Maori element in NZE and, on the other hand, marks the…

  17. Statistical Model Checking for Stochastic Hybrid Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Du, Dehui; Larsen, Kim Guldstrand

    2012-01-01

    This paper presents novel extensions and applications of the UPPAAL-SMC model checker. The extensions allow for statistical model checking of stochastic hybrid systems. We show how our race-based stochastic semantics extends to networks of hybrid systems, and indicate the integration technique ap...

  18. Response to Algarabel et al., 2012 "Recognition memory deficits in mild cognitive impairment". Reconsidering claims of familiarity disruptions in mild cognitive impairment.

    Science.gov (United States)

    Migo, E M; Westerberg, C E

    2014-01-01

    There is some debate over the relative impairment of recollection and familiarity in mild cognitive impairment (MCI). A recent publication by Algarabel et al. (2012, Recognition memory deficits in mild cognitive impairment, Aging, Neuropsychology, and Cognition, 19, 608-619) claims to undermine previous studies reporting preserved familiarity in patients with MCI. Here, we respond to their main criticisms, concluding that they are not sufficiently supported by the data presented. The role of recollection and familiarity in MCI remains unresolved and further work will be required to disentangle the mixed literature.

  19. Very mild Alzheimer’s disease is characterized by increased sensitivity to mnemonic interference

    Science.gov (United States)

    Monti, Jim M.; Balota, David A.; Warren, David E.; Cohen, Neal J.

    2014-01-01

    Early pathology and tissue loss in Alzheimer’s disease (AD) occurs in the hippocampus, a brain region that has recently been implicated in relational processing irrespective of delay. Thus, tasks that involve relational processing will especially tax the hippocampal memory system, and should be sensitive to even mild dysfunction typical of early AD. Here we used a short-lag, short-delay memory task previously shown to be sensitive to hippocampal integrity in an effort to discriminate cognitive changes due to healthy aging from those associated with very mild AD. Young adults, healthy older adults, and individuals with very mild AD (N = 30 for each group) participated in our investigation, which entailed attempting to find an exact match to a previously presented target among a series of stimuli that varied in perceptual similarity to the target stimulus. Older adults with very mild AD were less accurate than healthy older adults, who, in turn, were impaired relative to young adults. Older adults with very mild AD were also particularly susceptible to interference from intervening lure stimuli. A measure based on this finding was able to explain additional variance in differentiating those in the very mild stage of AD from healthy older adults after accounting for episodic memory and global cognition composite scores in logistic regression models. Our findings suggest that cognitive changes in early stage AD reflect aging along with an additional factor potentially centered on sensitivity to interference, thereby supporting multifactorial models of aging. PMID:24747209

  20. Very mild Alzheimer׳s disease is characterized by increased sensitivity to mnemonic interference.

    Science.gov (United States)

    Monti, Jim M; Balota, David A; Warren, David E; Cohen, Neal J

    2014-07-01

    Early pathology and tissue loss in Alzheimer׳s disease (AD) occurs in the hippocampus, a brain region that has recently been implicated in relational processing irrespective of delay. Thus, tasks that involve relational processing will especially tax the hippocampal memory system, and should be sensitive to even mild dysfunction typical of early AD. Here we used a short-lag, short-delay memory task previously shown to be sensitive to hippocampal integrity in an effort to discriminate cognitive changes due to healthy aging from those associated with very mild AD. Young adults, healthy older adults, and individuals with very mild AD (N=30 for each group) participated in our investigation, which entailed attempting to find an exact match to a previously presented target among a series of stimuli that varied in perceptual similarity to the target stimulus. Older adults with very mild AD were less accurate than healthy older adults, who, in turn, were impaired relative to young adults. Older adults with very mild AD were also particularly susceptible to interference from intervening lure stimuli. A measure based on this finding was able to explain additional variance in differentiating those in the very mild stage of AD from healthy older adults after accounting for episodic memory and global cognition composite scores in logistic regression models. Our findings suggest that cognitive changes in early stage AD reflect aging along with an additional factor potentially centered on sensitivity to interference, thereby supporting multifactorial models of aging.

  1. Comparison of the quick mild cognitive impairment (Qmci) screen and the SMMSE in screening for mild cognitive impairment.

    LENUS (Irish Health Repository)

    O'Caoimh, Rónán

    2012-09-01

    differentiating mild cognitive impairment (MCI) from normal cognition (NC) is difficult. The AB Cognitive Screen (ABCS) 135, sensitive in differentiating MCI from dementia, was modified to improve sensitivity and specificity, producing the quick mild cognitive impairment (Qmci) screen.

  2. Auditing Hybrid IT Environments

    Directory of Open Access Journals (Sweden)

    Georgiana Mateescu

    2014-01-01

    Full Text Available This paper presents a personal approach of auditing the hybrid IT environments consisting in both on premise and on demand services and systems. The analysis is performed from both safety and profitability perspectives and it aims to offer to strategy, technical and business teams a representation of the value added by the cloud programme within the company’s portfolio. Starting from the importance of the IT Governance in the actual business environments, we presented in the first section the main principles that drive the technology strategy in order to maximize the value added by IT assets in the business products. Section two summarizes the frameworks leveraged by our approach in order to implement the safety and profitability computation algorithms described in the third section. The paper concludes with benefits of our personal frameworks and presents the future developments.

  3. Problem solving verbal strategies in children with mild intellectual disability

    Directory of Open Access Journals (Sweden)

    Gligorović Milica

    2013-01-01

    Full Text Available Problem solving is a process conditioned by the development and application of efficient strategies. The aim of this research is to determine the level of verbal strategic approach to problem solving in children with mild intellectual disability (MID. The sample consists of 93 children with MID, aged between 10 and 14. Intellectual abilities of the examinees are within the defined range for mild intellectual disability (AM=60.45; SD=7.26. The examinees with evident physical, neurological, and emotional disorders were not included in the sample. The closed 20 Questions Test (20Q was used to assess the development and use of verbal strategy, where the examinee is presented with a poster containing 42 different pictures, and instructed to guess the picture selected by the examiner by asking no more than 20 closed questions. Test χ2, and Spearman and Pearson's correlation coefficient were used in statistical analysis. Research results indicate that most children with MID, aged between 10 and 14, use non-efficient strategy in solving the 20 Questions Test. Although strategic approach to problem solving is present in most children (72%, more than half of the examinees (53.5% use an inadequate strategy. Most children with MID have the ability to categorize concepts, however, they do not use it as a strategy in problem solving.

  4. Renewable Aromatics from the Degradation of Polystyrene under Mild Conditions

    KAUST Repository

    Al Jabri, Nouf M.

    2017-08-01

    Polystyrene (PS) is one of the most important polymers in the plastic sector due to its inexpensive cost as well as many preferred properties. Its international market is expected to achieve $28.2 billion by 2019. Although PS has a high calorific value of 87 GJ tonne-1, there is no a practical method to manage its waste but landfill. As a result, the PS debris in the oceans has reached 70% of the total plastic debris. This issue is considered as the main economical and environmental drivers of converting polystyrene waste into renewable chemical feedstocks. The aim of this work is to develop a catalyst for converting PS into renewable chemicals under mild conditions. We introduce FeCu/Alumina with excellent catalytic activity to fully degrade polystyrene with 66% liquid yield at 250 °C. The GC/MS confirmed that the primary products are in the gasoline range. Next, we present the bimetallic FeCo/Alumina and successfully we have obtained 100% PS conversion and 90% liquid yield with maintaining the products selectivity. Later, the tri-metallic FeCuCo/Alumina was synthesized and showed 100% PS conversion and 91% liquid yield. Surprisingly, ethylbenzene was the major product in which 80 wt. % was achieved with excellent reproducibility. Furthermore, the real waste Styrofoam was thermally and catalytically degraded at 250 °C. Interestingly, a high styrene content of 78 wt. % was recovered after 30 minutes of the reaction under mild conditions. Keeping in mind that a good balance between acidity and basicity is required to convert PS into aromatic under mild reaction conditions catalytically. Finally, the performance of the catalysts was compared to literature reports and showed novel liquid yields. In conclusion, we have synthesized cheap, easy to scale up, and efficient catalysts to fully degrade PS into high liquid yields of aromatics with excellent selectivity.

  5. Recent qualitative advances on hybrid organizations: taking stock, looking ahead

    NARCIS (Netherlands)

    Jolink, A.; Niesten, E.M.M.I.

    2012-01-01

    Where does the study of hybrids stand at present? Through a review of existing research, this paper provides a number of contributions to the literature on inter-organizational relations, or hybrids. For one, basing ourselves on the traditional theories used in the study of hybrids, we propose an in

  6. Hybrid Model of Content Extraction

    DEFF Research Database (Denmark)

    Qureshi, Pir Abdul Rasool; Memon, Nasrullah

    2012-01-01

    We present a hybrid model for content extraction from HTML documents. The model operates on Document Object Model (DOM) tree of the corresponding HTML document. It evaluates each tree node and associated statistical features like link density and text distribution across the node to predict signi...

  7. Expanding discourse repertoires with hybridity

    Science.gov (United States)

    Kelly, Gregory J.

    2012-09-01

    In "Hybrid discourse practice and science learning" Kamberelis and Wehunt present a theoretically rich argument about the potential of hybrid discourses for science learning. These discourses draw from different forms of "talk, social practice, and material practices" to create interactions that are "intertextually complex" and "interactionally dynamic." The hybrid discourse practices are described as involving the dynamic interplay of at least three key elements: "the lamination of multiple cultural frames, the shifting relations between people and their discourse, and the shifting power relations between and among people." Each of these elements requires a respective unit of analysis and are often mutually reinforcing. The authors present a theoretically cogent argument for the study of hybrid discourse practices and identify the potential such discourses may have for science education. This theoretical development leads to an analysis of spoken and written discourse around a set of educational events concerning the investigation of owl pellets by two fifth grade students, their classmates, and teacher. Two discourse segments are presented and analyzed by the authors in detail. The first is a discourse analysis of the dissection of the owl pellet by two students, Kyle and Max. The second analysis examines the science report of these same two students. In this article, I pose a number of questions about the study with the hope that by doing so I expand the conversation around the insightful analysis presented.

  8. From hybrid swarms to swarms of hybrids

    Science.gov (United States)

    The introgression of modern humans (Homo sapiens) with Neanderthals 40,000 YBP after a half-million years of separation, may have led to the best example of a hybrid swarm on earth. Modern trade and transportation in support of the human hybrids has continued to introduce additional species, genotyp...

  9. The Hybrid Museum: Hybrid Economies of Meaning

    DEFF Research Database (Denmark)

    Vestergaard, Vitus

    2013-01-01

    this article shows that there are two different museum mindsets where the second mindset leans towards participatory practices. It is shown how a museum can support a hybrid economy of meaning that builds on both a user generated economy of meaning and an institutional economy of meaning and adds value to both....... Such a museum is referred to as a hybrid museum....

  10. Landmarks in Hybrid Planning

    Directory of Open Access Journals (Sweden)

    Mohamed Elkawkagy

    2013-11-01

    Full Text Available Although planning techniques achieved a significant progress during recent years, solving many planning problem still difficult even for modern planners. In this paper, we will adopt landmark concept to hybrid planning setting - a method that combines reasoning about procedural knowledge and causalities. Land-marks are a well-known concept in the realm of classical planning. Recently, they have been adapted to hierarchical approaches. Such landmarks can be extracted in a pre-processing step from a declarative hierarchical planning domain and problem description. It was shown how this technique allows for a considerable reduction of the search space by eliminating futile plan development options before the actual planning. Therefore, we will present a new approach to in¬tegrate landmark pre-processing technique in the context of hierarchical planning with landmark technique in the classical planning. This integration allows to incorporate the ability of using extracted landmark tasks from hierarchical domain knowledge in the form of HTN and using landmark literals from classical planning. To this end, we will construct a transformation technique to transform the hybrid planning domain into a classical domain model. The method¬ologies in this paper have been implemented successfully, and we will present some experimental results that give evidence for the consid-erable performance increase gained through planning system.

  11. Hydraulic Hybrid Vehicles

    Science.gov (United States)

    EPA and the United Parcel Service (UPS) have developed a hydraulic hybrid delivery vehicle to explore and demonstrate the environmental benefits of the hydraulic hybrid for urban pick-up and delivery fleets.

  12. Hybrid Management in Hospitals

    DEFF Research Database (Denmark)

    Byrkjeflot, Haldor; Jespersen, Peter Kragh

    2010-01-01

    Artiklen indeholder et litteraturbaseret studium af ledelsesformer i sygehuse, hvor sundhedsfaglig ledelse og generel ledelse mikses til hybride ledelsesformer......Artiklen indeholder et litteraturbaseret studium af ledelsesformer i sygehuse, hvor sundhedsfaglig ledelse og generel ledelse mikses til hybride ledelsesformer...

  13. Review on intrauterine programming: Consequences in rodent models of mild diabetes and mild fat overfeeding are not mild.

    Science.gov (United States)

    Jawerbaum, A; White, V

    2017-04-01

    An adverse intrauterine programming occurs in diabetes and obesity as the consequence of an adverse maternal environment that affects the appropriate fetoplacental development and growth. Experimental models of diabetes and fat overfeeding have provided relevant tools to address putative mechanisms of the adverse intrauterine programming. The current knowledge far extends from the original thoughts of the resulting intrauterine programming of metabolic and cardiovascular diseases to a full range of alterations that affect multiple tissues, organs, and systems that will compromise the long-life health of the offspring. This review examines the postnatal effects of rodent models of mild diabetes and fat overfeeding, identifying the multiple organ derangements in the offspring resulting from mild maternal adverse conditions. In addition, the comparison of experimental models of severe diabetes and fat overfeeding and the crucial role of the placenta are discussed, providing an update of the actual scenario of the putative mechanisms and adverse consequences of maternal metabolic derangements. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Interspecific Hybridization within Ornamental Plants

    DEFF Research Database (Denmark)

    Kuligowska, Katarzyna

    The economic importance of the ornamental plant industry requires constant development of novel and high quality varieties. Traits attractive for production of new ornamental plants may not be available within the commercial cultivars, but broad genetic variation is present within the plant genera...... commercially important genera of ornamental plants: Kalanchoë and Hibiscus. The nature of hybridization barriers hampering hybrid production was investigated during pre- and post-fertilization stages. For each genus the interspecific crosses of Kalanchoë species and Hibiscus species, abnormal germination...

  15. Position list word aligned hybrid

    DEFF Research Database (Denmark)

    Deliege, Francois; Pedersen, Torben Bach

    2010-01-01

    Compressed bitmap indexes are increasingly used for efficiently querying very large and complex databases. The Word Aligned Hybrid (WAH) bitmap compression scheme is commonly recognized as the most efficient compression scheme in terms of CPU efficiency. However, WAH compressed bitmaps use a lot...... of storage space. This paper presents the Position List Word Aligned Hybrid (PLWAH) compression scheme that improves significantly over WAH compression by better utilizing the available bits and new CPU instructions. For typical bit distributions, PLWAH compressed bitmaps are often half the size of WAH...

  16. Interspecific Hybridization within Ornamental Plants

    DEFF Research Database (Denmark)

    Kuligowska, Katarzyna

    The economic importance of the ornamental plant industry requires constant development of novel and high quality varieties. Traits attractive for production of new ornamental plants may not be available within the commercial cultivars, but broad genetic variation is present within the plant genera...... commercially important genera of ornamental plants: Kalanchoë and Hibiscus. The nature of hybridization barriers hampering hybrid production was investigated during pre- and post-fertilization stages. For each genus the interspecific crosses of Kalanchoë species and Hibiscus species, abnormal germination...

  17. Resin Catalyst Hybrids

    Institute of Scientific and Technical Information of China (English)

    S. Asaoka

    2005-01-01

    @@ 1Introduction: What are resin catalyst hybrids? There are typically two types of resin catalyst. One is acidic resin which representative is polystyrene sulfonic acid. The other is basic resin which is availed as metal complex support. The objective items of this study on resin catalyst are consisting of pellet hybrid, equilibrium hybrid and function hybrid of acid and base,as shown in Fig. 1[1-5].

  18. Mesoscale hybrid calibration artifact

    Science.gov (United States)

    Tran, Hy D.; Claudet, Andre A.; Oliver, Andrew D.

    2010-09-07

    A mesoscale calibration artifact, also called a hybrid artifact, suitable for hybrid dimensional measurement and the method for make the artifact. The hybrid artifact has structural characteristics that make it suitable for dimensional measurement in both vision-based systems and touch-probe-based systems. The hybrid artifact employs the intersection of bulk-micromachined planes to fabricate edges that are sharp to the nanometer level and intersecting planes with crystal-lattice-defined angles.

  19. Mild cognitive impairment: safe to drive?

    Science.gov (United States)

    Olsen, Kirsty; Taylor, John-Paul; Thomas, Alan

    2014-06-01

    Driving is an important aspect of daily living and for many older people provides autonomy and psycho-social benefits. Cognitive impairment has been found to impact driving skills at the level of dementia, however, uncertainty remains around the impact of a diagnosis of the pre-dementia condition mild cognitive impairment. Current official guidelines are unclear, and assessment of fitness to drive can be problematical. This editorial examines current official guidance available to the clinician and problems with existing assessment as well as the current position of research specifically into MCI and driving, and considers future direction for research in this field.

  20. Semiautomatic MDF deburring tool. [Mild detonating fuse

    Energy Technology Data Exchange (ETDEWEB)

    Simonton, W.L.

    1976-03-31

    A device for semiautomatically deburring the ends of lengths of MDF (mild detonating fuse) was developed by the Automation Development group at Mound Laboratory. The device performs the deburring function by cutting a 0.002 in. x 0.002 in. chamfer on the MDF with small rotating blades. This air-operated, semiautomatic device provides improvement over the manual method of removing burrs by reduction in time and operator strain. A time study is underway to determine the time saved which is expected to be about 75 percent.

  1. Mild Traumatic Brain Injury in Translation

    OpenAIRE

    Levin, Harvey S.; Robertson, Claudia S.

    2013-01-01

    This Introduction to a Special Issue on Mild Traumatic Brain Injury (mTBI) highlights the methodological challenges in outcome studies and clinical trials involving patients who sustain mTBI. Recent advances in brain imaging and portable, computerized cognitive tasks have contributed to protocols that are sensitive to the effects of mTBI and efficient in time for completion. Investigation of civilian mTBI has been extended to single and repeated injuries in athletes and blast-related mTBI in ...

  2. Thyroid disorders in mild iodine deficiency

    DEFF Research Database (Denmark)

    Laurberg, P; Nøhr, S B; Pedersen, K M

    2000-01-01

    in elderly subjects, especially women, with risk of cardiac arrhythmias, osteoporosis, and muscle wasting. The hyperthyroidism is caused by autonomous nodular growth and function of the thyroid gland and it is accompanied by a high frequency of goiter. Pregnant women and small children are not immediately......Comparative epidemiologic studies in areas with low and high iodine intake and controlled studies of iodine supplementation have demonstrated that the major consequence of mild-to-moderate iodine deficiency for the health of the population is an extraordinarily high occurrence of hyperthyroidism...

  3. Model Reduction of Hybrid Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza

    systems are derived in this thesis. The results are used for output feedback control of switched nonlinear systems. Model reduction of piecewise affine systems is also studied in this thesis. The proposed method is based on the reduction of linear subsystems inside the polytopes. The methods which......High-Technological solutions of today are characterized by complex dynamical models. A lot of these models have inherent hybrid/switching structure. Hybrid/switched systems are powerful models for distributed embedded systems design where discrete controls are applied to continuous processes...... of hybrid systems, designing controllers and implementations is very high so that the use of these models is limited in applications where the size of the state space is large. To cope with complexity, model reduction is a powerful technique. This thesis presents methods for model reduction and stability...

  4. Intercalated hybrid graphite fiber composite

    Science.gov (United States)

    Gaier, James R. (Inventor)

    1993-01-01

    The invention is directed to a highly conductive lightweight hybrid material and methods of producing the same. The hybrid composite is obtained by weaving strands of a high strength carbon or graphite fiber into a fabric-like structure, depositing a layer of carbon onto the structure, heat treating the structure to graphitize the carbon layer, and intercalating the graphitic carbon layer structure. A laminate composite material useful for protection against lightning strikes comprises at least one layer of the hybrid material over at least one layer of high strength carbon or graphite fibers. The composite material of the present invention is compatible with matrix compounds, has a coefficient of thermal expansion which is the same as underlying fiber layers, and is resistant to galvanic corrosion in addition to being highly conductive. These materials are useful in the aerospace industry, in particular as lightning strike protection for airplanes.

  5. Regression Rate Study in HTPB/GOX Hybrid Rocket Motors.

    OpenAIRE

    Philmon George; Krishnan, S; Lalitha Ramachandran; P. M. Varkey; Raveendran, M.

    1996-01-01

    The theoretical and experimenIal studies on hybrid rocket motor combustion research are briefly reviewed and the need for a clear understanding of hybrid rocket fuel regression rate mechanism is brought out. A test facility established at the Indian Institute of Technology, Madras, for hybrid rocket motor research study is described.The results of an experimental study on hydroxyl terminated polybutadiene and gaseous oxygen hybrid rocket motor are presented. Fuel grains with ammonium perchlor...

  6. Numerical Modeling of MILD Combustion at High Pressure to Predict the Optimal Operating Conditions

    KAUST Repository

    Vanteru, Mahendra Reddy

    2017-02-01

    This Chapter presents numerical simulation on MILD combustion operating at high pressure. Influence of preheat and dilution of oxidizer and operating pressure on stabilization of MILD combustion are presented. Three different preheat temperatures (1100, 1300 and 1500 K) and three different dilution levels (3, 6 and 9% O2) are simulated over an operating pressure variation from 1 atm to 16 atm. A classical jet in hot coflow burner is considered for this study. Total of 45 cases are simulated and analyzed. Essential characteristics of MILD combustion, i.e., maximum temperature $$ (T_{max} ) $$, temperature rise $$ (\\\\Delta T) $$ and temperature distributions, are analyzed. The distribution of emissions OH and CO are also studied and presented. Well-stabilized MILD combustion is observed for all cases except for two cases with high preheated (1500 K). Peak temperature is observed to decrease with increasing operating pressure for a given level of preheat and dilution. OH mass faction is reduced with increasing pressure. The CO emissions show little sensitivity to operating pressure. However, CO mass fraction is slightly higher at 1 atm operating pressure as compared to 4 to 16 atm. Since the residence time of reactants increases as the operating pressure increases, well-stabilized MILD combustion is observed for all highly diluted and low temperature preheat cases (3% O2 and 1100 K).

  7. Realizing the Hybrid Library.

    Science.gov (United States)

    Pinfield, Stephen; Eaton, Jonathan; Edwards, Catherine; Russell, Rosemary; Wissenburg, Astrid; Wynne, Peter

    1998-01-01

    Outlines five projects currently funded by the United Kingdom's Electronic Libraries Program (eLib): HyLiFe (Hybrid Library of the Future), MALIBU (MAnaging the hybrid Library for the Benefit of Users), HeadLine (Hybrid Electronic Access and Delivery in the Library Networked Environment), ATHENS (authentication scheme), and BUILDER (Birmingham…

  8. Homoploid hybrid expectations

    Science.gov (United States)

    Homoploid hybrid speciation occurs when a stable, fertile, and reproductively isolated lineage results from hybridization between two distinct species without a change in ploidy level. Reproductive isolation between a homoploid hybrid species and its parents is generally attained via chromosomal re...

  9. Hybrid armature projectile

    Science.gov (United States)

    Hawke, Ronald S.; Asay, James R.; Hall, Clint A.; Konrad, Carl H.; Sauve, Gerald L.; Shahinpoor, Mohsen; Susoeff, Allan R.

    1993-01-01

    A projectile for a railgun that uses a hybrid armature and provides a seed block around part of the outer surface of the projectile to seed the hybrid plasma brush. In addition, the hybrid armature is continuously vaporized to replenish plasma in a plasma armature to provide a tandem armature and provides a unique ridge and groove to reduce plasama blowby.

  10. Intraply Hybrid Composite Design

    Science.gov (United States)

    Chamis, C. C.; Sinclair, J. H.

    1986-01-01

    Several theoretical approaches combined in program. Intraply hybrid composites investigated theoretically and experimentally at Lewis Research Center. Theories developed during investigations and corroborated by attendant experiments used to develop computer program identified as INHYD (Intraply Hybrid Composite Design). INHYD includes several composites micromechanics theories, intraply hybrid composite theories, and integrated hygrothermomechanical theory. Equations from theories used by program as appropriate for user's specific applications.

  11. Hybrid quantum information processing

    Energy Technology Data Exchange (ETDEWEB)

    Furusawa, Akira [Department of Applied Physics, School of Engineering, The University of Tokyo (Japan)

    2014-12-04

    I will briefly explain the definition and advantage of hybrid quantum information processing, which is hybridization of qubit and continuous-variable technologies. The final goal would be realization of universal gate sets both for qubit and continuous-variable quantum information processing with the hybrid technologies. For that purpose, qubit teleportation with a continuousvariable teleporter is one of the most important ingredients.

  12. Phosphorus absorption by of corn hybrids grown in savana soils; Absorcao de fosforo por hibridos de milho cultivados em solo de cerrado

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Cristiano [Fazenda Amazonas, Serra Azul, SP (Brazil); Muraoka, Takashi [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil)

    2002-12-01

    In the past years the savana region has been one of the main agricultural expansion areas, however their soils present high limitation for plant growth due their high acidity, low natural fertility, and low phosphorus availability. The objective of this work was to compare 30 of the main recommended maize (Zea mays L.) hybrids for the cerrado region in relation to their ability to absorb poorly-available soil phosphorus through the {sup 32}P isotopic dilution technique, using a Typic Dystrarox cultivated for 20 years and another under natural vegetation. Differences in absorption ability were observed among hybrids, seven classified as efficient, sixteen mildly efficient and seven inefficient, for the case of soil cultivated for 20 years. The plant growth and phosphorus concentration in the natural soil was lower due to its low fertility. (author)

  13. Hybrid reactors: Nuclear breeding or energy production?

    Energy Technology Data Exchange (ETDEWEB)

    Piera, Mireia [UNED, ETSII-Dp Ingenieria Energetica, c/Juan del Rosal 12, 28040 Madrid (Spain); Lafuente, Antonio; Abanades, Alberto; Martinez-Val, J.M. [ETSII-UPM, c/Jose Gutierrez Abascal 2, 28006 Madrid (Spain)

    2010-09-15

    After reviewing the long-standing tradition on hybrid research, an assessment model is presented in order to characterize the hybrid performance under different objectives. In hybrids, neutron multiplication in the subcritical blanket plays a major role, not only for energy production and nuclear breeding, but also for tritium breeding, which is fundamental requirement in fusion-fission hybrids. All three objectives are better achieved with high values of the neutron multiplication factor (k-eff) with the obvious and fundamental limitation that it cannot reach criticality under any event, particularly, in the case of a loss of coolant accident. This limitation will be very important in the selection of the coolant. Some general considerations will be proposed, as guidelines for assessing the hybrid potential in a given scenario. Those guidelines point out that hybrids can be of great interest for the future of nuclear energy in a framework of Sustainable Development, because they can contribute to the efficient exploitation of nuclear fuels, with very high safety features. Additionally, a proposal is presented on a blanket specially suited for fusion-fission hybrids, although this reactor concept is still under review, and new work is needed for identifying the most suitable blanket composition, which can vary depending on the main objective of the hybrid. (author)

  14. Electrochemical surface modification technique to impede mild steel corrosion using perfluorooctanoic acid

    Directory of Open Access Journals (Sweden)

    Shubha H Natarj

    2016-02-01

    Full Text Available The present work demonstrated that corrosion inhibition efficiency of electrochemically generated organic coat is remarkably effective than self-assembled monolayer (SAM generated by dip coating technique. Perfluorooctanoic Acid (PFOA is used to modify mild steel surface for effective protection. Infrared reflection absorption spectroscopy and contact angle measurements substantiate the modification of mild steel surface and its effect on surface hydrophobicity. A comparison between electrochemical properties of PFOA SAM generated by dip coat method (DC-PFOA and PFOA coat generated by electrochemical method (EC-PFOA is presented. Electrochemical measurements reveal that the corrosion protection efficiency of EC-PFOA (91% is much superior to DC-PFOA (28%.

  15. Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin.

    Science.gov (United States)

    Kawa, Lizan; Arborelius, Ulf P; Yoshitake, Takashi; Kehr, Jan; Hökfelt, Tomas; Risling, Mårten; Agoston, Denes

    2015-08-15

    Exposure to improvised explosive devices can result in a unique form of traumatic brain injury--blast-induced traumatic brain injury (bTBI). At the mild end of the spectrum (mild bTBI [mbTBI]), there are cognitive and mood disturbances. Similar symptoms have been observed in post-traumatic stress disorder caused by exposure to extreme psychological stress without physical injury. A role of the monoaminergic system in mood regulation and stress is well established but its involvement in mbTBI is not well understood. To address this gap, we used a rodent model of mbTBI and detected a decrease in immobility behavior in the forced swim test at 1 d post-exposure, coupled with an increase in climbing behavior, but not after 14 d or later, possibly indicating a transient increase in anxiety-like behavior. Using in situ hybridization, we found elevated messenger ribonucleic acid levels of both tyrosine hydroxylase and tryptophan hydroxylase 2 in the locus coeruleus and the dorsal raphe nucleus, respectively, as early as 2 h post-exposure. High-performance liquid chromatography analysis 1 d post-exposure primarily showed elevated noradrenaline levels in several forebrain regions. Taken together, we report that exposure to mild blast results in transient changes in both anxiety-like behavior and brain region-specific molecular changes, implicating the monoaminergic system in the pathobiology of mbTBI.

  16. Thyroid disorders in mild iodine deficiency.

    Science.gov (United States)

    Laurberg, P; Nøhr, S B; Pedersen, K M; Hreidarsson, A B; Andersen, S; Bülow Pedersen, I; Knudsen, N; Perrild, H; Jørgensen, T; Ovesen, L

    2000-11-01

    Comparative epidemiologic studies in areas with low and high iodine intake and controlled studies of iodine supplementation have demonstrated that the major consequence of mild-to-moderate iodine deficiency for the health of the population is an extraordinarily high occurrence of hyperthyroidism in elderly subjects, especially women, with risk of cardiac arrhythmias, osteoporosis, and muscle wasting. The hyperthyroidism is caused by autonomous nodular growth and function of the thyroid gland and it is accompanied by a high frequency of goiter. Pregnant women and small children are not immediately endangered but the consequences of severe iodine deficiency for brain development are grave and a considerable safety margin is advisable. Moreover, a shift toward less malignant types of thyroid cancer and a lower radiation dose to the thyroid in case of nuclear fallout support that mild-to-moderate iodine deficiency should be corrected. However, there is evidence that a high iodine intake may be associated with more autoimmune hypothyroidism, and that Graves' disease may manifest at a younger age and be more difficult to treat. Hence, the iodine intake should be brought to a level at which iodine deficiency disorders are avoided but not higher. Iodine supplementation programs should aim at relatively uniform iodine intake, avoiding deficient or excessive iodine intake in subpopulations. To adopt such a strategy, surveillance programs are needed.

  17. DESIGN AND DEVELOPMENT OF MILD COMBUSTION BURNER

    Directory of Open Access Journals (Sweden)

    M.M. Noor

    2013-12-01

    Full Text Available This paper discusses the design and development of the Moderate and Intense Low oxygen Dilution (MILD combustion burner using Computational Fluid Dynamics (CFD simulations. The CFD commercial package was used to simulate preliminary designs for the burner before the final design was sent to the workshop for fabrication. The burner is required to be a non-premixed and open burner. To capture and use the exhaust gas, the burner was enclosed within a large circular shaped wall with an opening at the top. An external EGR pipe was used to transport the exhaust gas which was mixed with the fresh oxidant. To control the EGR and exhaust flow, butterfly valves were installed at the top opening as a damper to close the exhaust gas flow at a certain ratio for EGR and exhaust out to the atmosphere. High temperature fused silica glass windows were installed to view and capture images of the flame and analyze the flame propagation. The burner simulation shows that MILD combustion was achieved for the oxygen mole fraction of 3-13%. The final design of the burner was fabricated and ready for the experimental validation.

  18. A new aubergine disease caused by a whitefly‐borne strain of Tomato mild mottle virus (TomMMoV)

    National Research Council Canada - National Science Library

    Dombrovsky, A; Sapkota, R; Lachman, O; Pearlsman, M; Antignus, Y

    2013-01-01

    The aims of the present study were to further characterize the causal agent of a new viral disease of aubergines in Israel, first observed in 2003 and tentatively named eggplant mild leaf mottle virus ( EMLMV...

  19. A molecular hybrid polyoxometalate-organometallic moieties and its relevance to supercapacitors in physiological electrolytes

    Science.gov (United States)

    Chinnathambi, Selvaraj; Ammam, Malika

    2015-06-01

    Supercapacitors operating in physiological electrolytes are of great relevance for both their environmentally friendly aspect as well as the possibility to be employed for powering implantable microelectronic devices using directly biological fluids as electrolytes. Polyoxometalate (POMs) have been proven to be useful for supercapacitors in acidic media. However, in neutral pH, POMs are usually not stable. One relevant alternative is to stabilize POMs by pairing them with organic moieties to form hybrids. In this study, we combined K6P2Mo18O62·12H2O (P2Mo18) with Ru(bpy)3Cl2.6H2O (Ru(bpy)). The synthesis was carried out with and without the mild reducing agent KI. The hybrids were characterized by CHN analysis, TEM, FT-IR, XRD, TGA and cyclic voltammetry. CHN elemental analysis revealed that one mole [P2Mo18O62]6- is paired with 3 mol [Ru(bpy)3]2+ to form [Ru(bpy)3]3PMo18O62·nH2O. With KI present, [P2Mo18O62]6- is linked to 3.33 mol to yield [Ru(bpy)3]3.33PMo18O62·mH2O. Excess of Ru(bpy) in [Ru(bpy)3]3.33PMo18O62·mH2O was further confirmed by TEM, FT-IR, XRD, TGA and cyclic voltammetry. In turn, hybrid composition is found to strongly influence the supercapacitor behavior. The hybrid rich in Ru(bpy) is found to perform better for supercapacitors in physiological electrolytes. 125 F g-1 and 68 F g-1 are the capacitance values obtained with [Ru(bpy)3]3.33PMo18O62·mH2O and [Ru(bpy)3]3PMo18O62·nH2O, respectively. In terms of specific energy densities, 3.5 Wh kg-1 and 2 Wh kg-1 were obtained for both hybrid simultaneously. The difference in supercapacitor performance between both hybrids is also noticed in impedance spectroscopy which showed that [Ru(bpy)3]3.33PMo18O62·mH2O has lower electron transfer resistance if compared to [Ru(bpy)3]3PMo18O62·nH2O. Finally, if compared of parent K6P2Mo18O62·12H2O, the stability of both hybrids is found to be highly improved.

  20. Amnestic mild cognitive impairment with low myocardial metaiodobenzylguanidine uptake

    Science.gov (United States)

    Sakakibara, Ryuji; Ogata, Takeshi; Haruta, Masayuki; Kishi, Masahiko; Tsuyusaki, Yohei; Tateno, Akihiko; Tateno, Fuyuki; Mouri, Takayuki

    2012-01-01

    Objectives: We reported cases of amnestic mild cognitive impairment (MCI) without the core clinical features of dementia with Lewy bodies (DLB) (dementia and spontaneous parkinsonism) with low uptake in 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. Methods: During a 3-year period at a university clinic, we had 254 patients with memory complaints; 106 men, 148 women; mean age 72.5 years (48-95 years). In all patients we performed neurologic examination; memory tests including the MMSE, ADAScog, FAB and additional WMS-R; and imaging tests including brain MRI, SPECT and MIBG scintigraphy. Results: The criteria of amnestic MCI were fulfilled in 44 patients; and 13 of them (30%) showed low MIBG uptake. They had the following: uniformly elderly, with an equal sex ratio, have relatively slow progression, preserved general cognitive function (MMSE 24.8/30). In addition to memory impairment, they commonly showed low frontal function by FAB (12.5/18) and some had mild visual hallucination (5). Other than memory disorder, they had autonomic disorder (nocturia in 7, constipation in 2, postural hypotension in one), REM sleep behavioral disorder (in 3) and occipital hypoperfusion by SPECT (in 5). Conclusion: This cohort of multidomain amnestic MCI cases may present with early stage DLB because of the presence of low MIBG uptake. Clinically, they commonly have low FAB, and may have visual hallucination, autonomic and sleep disorders. PMID:23383388

  1. A hybrid manifold learning algorithm for the diagnosis and prognostication of Alzheimer's disease.

    Science.gov (United States)

    Dai, Peng; Gwadry-Sridhar, Femida; Bauer, Michael; Borrie, Michael

    The diagnosis of Alzheimer's disease (AD) requires a variety of medical tests, which leads to huge amounts of multivariate heterogeneous data. Such data are difficult to compare, visualize, and analyze due to the heterogeneous nature of medical tests. We present a hybrid manifold learning framework, which embeds the feature vectors in a subspace preserving the underlying pairwise similarity structure, i.e. similar/dissimilar pairs. Evaluation tests are carried out using the neuroimaging and biological data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) in a three-class (normal, mild cognitive impairment, and AD) classification task using support vector machine (SVM). Furthermore, we make extensive comparison with standard manifold learning algorithms, such as Principal Component Analysis (PCA), Principal Component Analysis (PCA), Multidimensional Scaling (MDS), and isometric feature mapping (Isomap). Experimental results show that our proposed algorithm yields an overall accuracy of 85.33% in the three-class task.

  2. Hybrid ion, atom and light trap

    CERN Document Server

    Jyothi, S; Ram, N Bhargava; Rangwala, S A

    2013-01-01

    We present an unique experimental arrangement which permits the simultaneous trapping and cooling of ions and neutral atoms, within a Fabry-Perot (FP) cavity. The versatility of this hybrid trap experiment enables a variety of studies with trapped mixtures. The motivations behind the production of such a hybrid trap system are explained, followed by details of how the experiment is put together. Several experiments that have been performed with this system are presented and some opportunities with this system are discussed. However the primary emphasis is focussed on the aspects that pertain to the trapped ions, in this hybrid system.

  3. Overview on hybrid propulsion

    Science.gov (United States)

    Calabro, M.

    2011-10-01

    Aside of research works, this historical survey shows propulsion units used by students for small satellites and for gas generation, or those for the Space Ship One, even if LOx/HTPB was studied and tested in large motors for its potential very low cost; however, this combination highlights a series of technical problems without any performance advantage over the existing LOx/Kerosene family and never been operational for ETO applications. The particularity of hybrid propulsion is to use the state-of-the-art of both liquids and solids; the only show stopper is the propellant itself. The past work focused on LOx/HTPB (selected for its low cost) appears to be a dead-end (combustion problems and global low performances resulting from a high level of residuals). The solution that appears through the past experience is the addition of hydrides to a binder (HTPB or other) or to a binder and a homogeneous fuel or a mixture of both, with or without others additives; within these solutions some will not present any manufacturing problem and some may have a low cost. Nevertheless, the studies of the following phases have to demonstrate the compatibility of the potential regression rate range with a high-performance global design of a hybrid Motor and the manufacturing at a reasonable cost of a hydride giving a high level of performances.

  4. Using the Wechsler Memory Scale-III to detect malingering in mild traumatic brain injury.

    Science.gov (United States)

    Ord, Jonathan S; Greve, Kevin W; Bianchini, Kevin J

    2008-07-01

    This study examined the classification accuracy of the WMS-III primary indices in the detection of Malingered Neurocognitive Dysfunction (MND) in Traumatic Brain Injury (TBI) using a known-groups design. Sensitivity, specificity, and positive predictive power are presented for a range of index scores comparing mild TBI non-malingering (n = 34) and mild TBI malingering (n = 31) groups. A moderate/severe TBI non-malingering (n = 28) and general clinical group (n = 93) are presented to examine specificity in these samples. In mild TBI, sensitivities for the primary indices ranged from 26% to 68% at 97% specificity. Three systems used to combine all eight index scores were also examined and all achieved at least 58% sensitivity at 97% specificity in mild TBI. Specificity was generally lower in the moderate/severe TBI and clinical comparison groups. This study indicates that the WMS-III primary indices can accurately identify malingered neurocognitive dysfunction in mild TBI when used as part of a comprehensive classification system.

  5. Electrical potential-assisted DNA hybridization. How to mitigate electrostatics for surface DNA hybridization.

    Science.gov (United States)

    Tymoczko, Jakub; Schuhmann, Wolfgang; Gebala, Magdalena

    2014-12-24

    Surface-confined DNA hybridization reactions are sensitive to the number and identity of DNA capture probes and experimental conditions such as the nature and the ionic strength of the electrolyte solution. When the surface probe density is high or the concentration of bulk ions is much lower than the concentration of ions within the DNA layer, hybridization is significantly slowed down or does not proceed at all. However, high-density DNA monolayers are attractive for designing high-sensitivity DNA sensors. Thus, circumventing sluggish DNA hybridization on such interfaces allows a high surface concentration of target DNA and improved signal/noise ratio. We present potential-assisted hybridization as a strategy in which an external voltage is applied to the ssDNA-modified interface during the hybridization process. Results show that a significant enhancement of hybridization can be achieved using this approach.

  6. Hybridization and extinction.

    Science.gov (United States)

    Todesco, Marco; Pascual, Mariana A; Owens, Gregory L; Ostevik, Katherine L; Moyers, Brook T; Hübner, Sariel; Heredia, Sylvia M; Hahn, Min A; Caseys, Celine; Bock, Dan G; Rieseberg, Loren H

    2016-08-01

    Hybridization may drive rare taxa to extinction through genetic swamping, where the rare form is replaced by hybrids, or by demographic swamping, where population growth rates are reduced due to the wasteful production of maladaptive hybrids. Conversely, hybridization may rescue the viability of small, inbred populations. Understanding the factors that contribute to destructive versus constructive outcomes of hybridization is key to managing conservation concerns. Here, we survey the literature for studies of hybridization and extinction to identify the ecological, evolutionary, and genetic factors that critically affect extinction risk through hybridization. We find that while extinction risk is highly situation dependent, genetic swamping is much more frequent than demographic swamping. In addition, human involvement is associated with increased risk and high reproductive isolation with reduced risk. Although climate change is predicted to increase the risk of hybridization-induced extinction, we find little empirical support for this prediction. Similarly, theoretical and experimental studies imply that genetic rescue through hybridization may be equally or more probable than demographic swamping, but our literature survey failed to support this claim. We conclude that halting the introduction of hybridization-prone exotics and restoring mature and diverse habitats that are resistant to hybrid establishment should be management priorities.

  7. [Dermatomyositis. Presentation of a mild to moderate case with early dysphagia].

    Science.gov (United States)

    Sánchez Carbonell, M; Climent Antolí, H; Leandro Fonseca, A L; Paricio Talayero, J M; Escrivá Tomás, P

    2015-01-01

    We report the case of a twelve year old female patient with juvenile dermatomyositis. The diagnosis was made in our unit a few days after starting with proximal muscular weakness and a skin rash. A combination of oral corticosteroids and methotrexate was administered. There was an initial improvent in the skin lesions, but with no changes in the muscle weakness. The appearance of dysphagia a few days after starting the treatment led us to add three pulses of parenteral methylprednisolone to her initial treatment. We report the case to illustrate the difficulties in deciding initial treatment options.

  8. Spoof Plasmon Hybridization

    CERN Document Server

    Zhang, Jingjing; Luo, Yu; Shen, Xiaopeng; Maier, Stefan A; Cui, Tie Jun

    2016-01-01

    Plasmon hybridization between closely spaced nanoparticles yields new hybrid modes not found in individual constituents, allowing for the engineering of resonance properties and field enhancement capabilities of metallic nanostructure. Experimental verifications of plasmon hybridization have been thus far mostly limited to optical frequencies, as metals cannot support surface plasmons at longer wavelengths. Here, we introduce the concept of 'spoof plasmon hybridization' in highly conductive metal structures and investigate experimentally the interaction of localized surface plasmon resonances (LSPR) in adjacent metal disks corrugated with subwavelength spiral patterns. We show that the hybridization results in the splitting of spoof plasmon modes into bonding and antibonding resonances analogous to molecular orbital rule and plasmonic hybridization in optical spectrum. These hybrid modes can be manipulated to produce enormous field enhancements (larger than 5000) by tuning the separation between disks or alte...

  9. Mechanical property characterization of intraply hybrid composites

    Science.gov (United States)

    Chamis, C. C.; Lark, R. F.; Sinclair, J. H.

    1979-01-01

    An investigation of the mechanical properties of intraply hybrids made from graphite fiber/epoxy matrix hybridized with secondary S-glass or Kevlar 49 fiber composites is presented. The specimen stress-strain behavior was determined, showing that mechanical properties of intraply hybrid composites can be measured with available methods such as the ten-degree off-axis test for intralaminar shear, and conventional tests for tensile, flexure, and Izod impact properties. The results also showed that combinations of high modulus graphite/S-glass/epoxy matrix composites exist which yield intraply hybrid laminates with the best 'balanced' properties, and that the translation efficiency of mechanical properties from the constituent composites to intraply hybrids may be assessed with a simple equation.

  10. Marine Fish Hybridization

    KAUST Repository

    He, Song

    2017-04-01

    Natural hybridization is reproduction (without artificial influence) between two or more species/populations which are distinguishable from each other by heritable characters. Natural hybridizations among marine fishes were highly underappreciated due to limited research effort; it seems that this phenomenon occurs more often than is commonly recognized. As hybridization plays an important role in biodiversity processes in the marine environment, detecting hybridization events and investigating hybridization is important to understand and protect biodiversity. The first chapter sets the framework for this disseration study. The Cohesion Species Concept was selected as the working definition of a species for this study as it can handle marine fish hybridization events. The concept does not require restrictive species boundaries. A general history and background of natural hybridization in marine fishes is reviewed during in chapter as well. Four marine fish hybridization cases were examed and documented in Chapters 2 to 5. In each case study, at least one diagnostic nuclear marker, screened from among ~14 candidate markers, was found to discriminate the putative hybridizing parent species. To further investigate genetic evidence to support the hybrid status for each hybrid offspring in each case, haploweb analysis on diagnostic markers (nuclear and/or mitochondrial) and the DAPC/PCA analysis on microsatellite data were used. By combining the genetic evidences, morphological traits, and ecological observations together, the potential reasons that triggered each hybridization events and the potential genetic/ecology effects could be discussed. In the last chapter, sequences from 82 pairs of hybridizing parents species (for which COI barcoding sequences were available either on GenBank or in our lab) were collected. By comparing the COI fragment p-distance between each hybridizing parent species, some general questions about marine fish hybridization were discussed: Is

  11. Swimming and Persons with Mild Persistant Asthma

    Directory of Open Access Journals (Sweden)

    Mirjana Arandelovic

    2007-01-01

    Full Text Available The aim of our study was to analyze the effect of recreational swimming on lung function and bronchial hyperresponsiveness (BHR in patients with mild persistent asthma. This study included 65 patients with mild persistent asthma, who were divided into two groups: experimental group A (n = 45 and control group B (n = 20. Patients from both groups were treated with low doses of inhaled corticosteroids (ICS and short-acting β2 agonists salbutamol as needed. Our program for patients in group A was combined asthma education with swimming (twice a week on a 1-h basis for the following 6 months. At the end of the study, in Group A, we found a statistically significant increase of lung function parameters FEV1 (forced expiratory volume in 1 sec (3.55 vs. 3.65 (p < 0.01, FVC (forced vital capacity (4.27 vs. 4.37 (p < 0.05, PEF (peak expiratory flow (7.08 vs. 7.46 (p < 0.01, and statistically significant decrease of BHR (PD20 0.58 vs. 2.01 (p < 0.001. In Group B, there was a statistically significant improvement of FEV1 3.29 vs. 3.33 (p < 0.05 and although FVC, FEV1/FVC, and PEF were improved, it was not significant. When Groups A and B were compared at the end of the study, there was a statistically significant difference of FVC (4.01 vs. 4.37, FEV1 (3.33 vs. 3.55, PEF (6.79 vs.7.46, and variability (p <0.001, and statistically significantly decreased BHR in Group A (2.01 vs. 1.75 (p < 0.001. Engagement of patients with mild persistent asthma in recreational swimming in nonchlorinated pools, combined with regular medical treatment and education, leads to better improvement of their parameters of lung function and also to more significant decrease of their airway hyperresponsiveness compared to patients treated with traditional medicine

  12. Chromosome 22q11.2 Deletion Syndrome Presenting as Adult Onset Hypoparathyroidism: Clues to Diagnosis from Dysmorphic Facial Features

    Directory of Open Access Journals (Sweden)

    Sira Korpaisarn

    2013-01-01

    Full Text Available We report a 26-year-old Thai man who presented with hypoparathyroidism in adulthood. He had no history of cardiac disease and recurrent infection. His subtle dysmorphic facial features and mild intellectual impairment were suspected for chromosome 22q11.2 deletion syndrome. The diagnosis was confirmed by fluorescence in situ hybridization, which found microdeletion in 22q11.2 region. The characteristic facial appearance can lead to clinical suspicion of this syndrome. The case report emphasizes that this syndrome is not uncommon and presents as a remarkable variability in the severity and extent of expression. Accurate diagnosis is important for genetic counseling and long-term health supervision by multidisciplinary team.

  13. New materials strategies for creating hybrid electronic circuitry (Presentation Video)

    Science.gov (United States)

    Marks, Tobin J.

    2013-09-01

    This lecture focuses on the challenging design and realization of new materials for creating unconventional electronic circuitry. Fabrication methodologies to achieve these goals include high-throughput, large-area printing techniques. Materials design topics to be discussed include: 1. Rationally designed high-mobility p- and n-type organic semiconductors for printed organic CMOS, 2. Polycrystalline and amorphous oxide semiconductors for transparent and mechanically flexible electronics, 3) Self-assembled and printable high-k nanodielectrics enabling ultra-large capacitance, low leakage, high breakdown fields, minimal trapped interfacial charge, and device radiation hardness. 4) Combining these materials sets to fabricate a variety of high-performance thin-film transistor-based devices.

  14. Impressions of the Meson Spectrum: Hybrids & Exotics, present and future

    Energy Technology Data Exchange (ETDEWEB)

    Pennington, Michael R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-03-25

    It has long been expected that the spectrum of hadrons in QCD would be far richer and extensive than experiment has so far revealed. While there have been experimental hints of this richness for some time, it is really only in the last few years that dramatic progress has been seen in the exploration both experimentally and in calculations on the lattice. Precision studies enabled by new technology both with detectors and high performance computations are converging on an understanding of the spectrum in strong coupling QCD. These methodologies are laying the foundation for a decade of potential discovery that electro and photoproduction experiments at Jefferson Lab, which when combined with key results on B and charmonium decays from both e+e? and pp colliders, should turn mere impressions of the light meson spectrum into a high definition picture.

  15. Design of a hybrid command and control mobile botnet: Presentation

    CSIR Research Space (South Africa)

    Pieterse, H

    2013-03-01

    Full Text Available smartphones running the Android OS. Geinimi (Wyatt 2012) is the first Android malware to display functionalities closely relating to that of botnets. The malware opened a backdoor on the infected device and transmitted the collected information to a... obfuscator to hide botnet activities and encrypted chunks of the C&C traffic (Wyatt 2012). The three versions of mobile malware described above established the platform for development of future mobile botnets. They revealed that it is possible to take...

  16. Mild desalination of various raw water streams.

    Science.gov (United States)

    Groot, C K; van den Broek, W B P; Loewenberg, J; Koeman-Stein, N; Heidekamp, M; de Schepper, W

    2015-01-01

    For chemical industries, fresh water availability is a pre-requisite for sustainable operation. However, in many delta areas around the world, fresh water is scarce. Therefore, the E4 Water project (www.e4water.eu) comprises a case study at the Dow site in Terneuzen, The Netherlands, which is designed to develop commercial applications for mild desalination of brackish raw water streams from various origins to enable reuse in industry or agriculture. This study describes an effective two-stage work process, which was used to narrow down a broad spectrum of desalination technologies to a selection of the most promising techniques for a demonstration pilot at 2-4 m³/hour. Through literature study, laboratory experiments and multi-criteria analysis, nanofiltration and electrodialysis reversal were selected, both having the potential to attain the objectives of E4Water at full scale.

  17. Mild Cognitive Impairment Status and Mobility Performance

    DEFF Research Database (Denmark)

    Pedersen, Mette; Holt, Nicole E; Grande, Laura

    2014-01-01

    BACKGROUND: The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults. METHODS......MCI), nonmemory domains (naMCI), and multiple domains (mdMCI). Linear regression models were used to assess the association between MCI status and mobility performance in the Habitual Gait Speed, Figure of 8 Walk, Short Physical Performance Battery, and self-reported Late Life Function and Disability Instrument......). All MCI subtypes performed significantly worse than No-MCI on all mobility measures (p Figure of 8 Walk (p = .054) and Basic Lower Extremity (p = .11). Moreover, compared with aMCI, mdMCI manifested worse performance on the Figure of 8 Walk and Short...

  18. Photochromic mesoporous hybrid coatings

    Science.gov (United States)

    Raboin, L.; Matheron, M.; Gacoin, T.; Boilot, J.-P.

    2008-09-01

    Spirooxazine (SO) photochromic molecules were trapped in sol-gel matrices. In order to increase the colourability and improve mechanical properties of sol-gel photochromic films, we present an original strategy in which SO photochromic molecules were dispersed in mesoporous organized films using the impregnation technique. Well-ordered organosilicate mesoporous coatings with the 3D-hexagonal symmetry were prepared by the sol-gel technique. These robust mesoporous films, which contain high amounts of hydrophobic methyl groups at the pore surface, offer optimized environments for photochromic dyes dispersed by impregnation technique. After impregnation by a spirooxazine solution, the photochromic response is only slightly slower when compared with mesostructured or soft sol-gel matrices, showing that mesoporous organized hybrid matrix are good host for photochromic dyes. Moreover, the molecular loading in films is easily adjustable in a large range using multi-impregnation procedure and increasing the film thickness leading to coatings for optical switching devices.

  19. Microbiologically mediated reduction in the pitting of mild steel overlaid with plywood

    Energy Technology Data Exchange (ETDEWEB)

    Soracco, R J; Berger, L R; Berger, J A; Mayack, L A; Pope, D H; Wilde, E W

    1984-01-01

    Laboratory experiments were conducted to determine the role of microorganisms in the pitting of mild steel flooring, which had been overlaid with plywood. The experimental setups consisted of 4.8 mm (3/16 in.) mild steel plates covered with 12.7 mm (1/2 in.) thick pieces of plywood which were exposed to several different aqueous media supplemented with various combinations of a soil suspension and selected inorganic and organic compounds. Half of the replicate metal-wood-water setups were sterilized and aseptically maintained during incubation after which they were checked for the presence of viable microorganisms and pitting of the mild steel. Results of the first set of experiments showed that pitting of the mild steel specimens in many of these setups occurred after a reasonably short incubation period (3 to 6 months). However, the method used to exclude microorganisms by sterilizing the components separately was unsuccessful. In a second set of experiments, setups were sterilized by exposure to gamma irradiation after they had been assembled. The sterilized setups remained sterile after incubation while those which were not originally sterile still contained viable microorganisms. Pitting of the mild steel specimens was more severe when they were exposed to sterile conditions than when viable microorganisms were present. These experiments showed that while microorganisms are known to enhance corrosion processes in some circumstances, their presence can reduce corrosion in others.

  20. Vergence in mild traumatic brain injury: A pilot study

    Directory of Open Access Journals (Sweden)

    Dora Szymanowicz, OD, MS

    2012-10-01

    Full Text Available Vergence dysfunction in individuals with mild traumatic brain injury (mTBI may have a negative effect on quality of life, functional abilities, and rehabilitative progress. In this study, we used a range of dynamic and static objective and subjective measures of vergence to assess 21 adult patients with mTBI and nearwork symptoms. The results were compared with 10 control adult subjects. With respect to dynamic parameters, responses in those with mTBI were slowed, variable, and delayed. With respect to static parameters, reduced near point of convergence and restricted near vergence ranges were found in those with mTBI. The present results provide evidence for the substantial adverse effect of mTBI on vergence function.

  1. Mild Diabetes Models and Their Maternal-Fetal Repercussions

    Directory of Open Access Journals (Sweden)

    D. C. Damasceno

    2013-01-01

    Full Text Available The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.

  2. How Do Children With Mild Intellectual Disabilities Perceive Loneliness?

    Directory of Open Access Journals (Sweden)

    Kalliopi Papoutsaki

    2013-02-01

    Full Text Available The present study examined 154 children with mild intellectual disability (MID attending special schools with regard to their reports of loneliness. Semi-structured interviews revealed that more than half of the students with MID reported feelings of loneliness. They tend to have as friends children from their neighborhood, friends of their siblings, children of their parents’ friends and from their school. Lonely children with MID tend to attribute their isolation to interpersonal deficits, lack of contact with peers and physical appearance, while one fourth cannot justify why they do not have any friends. Children with MID report that they withdraw from social interactions, engage in solitary activities and actively look for friends to cope with their feelings of loneliness and rejection, while very few resort to physical or verbal aggression. Moreover, boys and children living in smaller towns reported less feelings of loneliness than girls and children living in the capital.

  3. Hydrodynamical interaction of mildly relativistic ejecta with an ambient medium

    CERN Document Server

    Suzuki, Akihiro; Shigeyama, Toshikazu

    2016-01-01

    Hydrodynamical interaction of spherical ejecta freely expanding at mildly relativistic speeds into an ambient cold medium is studied in semi-analytical and numerical ways to investigate how ejecta produced in energetic stellar explosions dissipate their kinetic energy through the interaction with the surrounding medium. We especially focus on the case in which the circumstellar medium is well represented by a steady wind at a constant mass-loss rate having been ejected from the stellar surface prior to the explosion. As a result of the hydrodynamical interaction, the ejecta and circumstellar medium are swept by the reverse and forward shocks, leading to the formation of a geometrically thin shell. We present a semi-analytical model describing the dynamical evolution of the shell and compare the results with numerical simulations. The shell can give rise to bright emission as it gradually becomes transparent to photons. while it is optically thick. We develop an emission model for the expected emission from th...

  4. DISSIPATION OF WAVE ENERGY ON VERY MILD SLOPE

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper presents the analysis and calculation of wave attenuation when waves travel on sand bed, sand ripple bed and muddy bed, respectively. The study shows that (1) The dissipation of wave energy due to bottom percolation may be neglected on sand bed; (2) The wave attenuation due to the friction of sand ripples is one order higher than that of flat sand bed and (3) The energy loss of waves propagating on muddy bed is the largest. Then, the equivalent coefficients of friction are calculated in order to compare with the solution by the bottom-friction model. Wave attenuation are also computed by the Bingham-model and the principle of conservation of wave energy flux on very mild muddy slope. The results coincide well with the wave information from the Lianyungang Wave Observation Station. Theoretical prediction proves that the equivalent coefficients of friction strongly rely on water depth, which inerease with decreasing depth.

  5. Mild cognitive impairment in Parkinson disease: heterogenous mechanisms.

    Science.gov (United States)

    Jellinger, Kurt A

    2013-01-01

    Cognitive impairment is common in Parkinson disease (PD), with long-term longitudinal studies reporting that most PD patients develop dementia. A high proportion of patients with PD and mild cognitive impairment (MCI) progress to dementia within a short time. Impairments occur in a range of cognitive domains, but single-domain impairment is more common than multiple one, non-amnestic more common than amnestic impairment. Although the term MCI applied to PD (PD-MCI) is not without controversy due to the lack of uniform diagnostic consensus criteria, the biological validity of PD-MCI is supported by many recent studies that show heterogenous mechanisms in the clinical presentation, neuropsychology, neuroimaging, biomarkers, and neuropathology, suggesting abnormal metabolic network activities involving several cortical and subcortical nervous systems. Prospective studies using specific biomarkers, including amyloid imaging, and cerebro-spinal fluid biomarkers are warranted for an exact diagnosis and prognostic assessment of early cognitive deficits in PD patients.

  6. Cognitive based interventions for elderly people with mild cognitive impairement: Review of effects and efficacy

    Directory of Open Access Journals (Sweden)

    Fátima González Palau

    2012-07-01

    Full Text Available Due to the significant increase in the percentage of older adults, as well as degenerative diseases, there is growing interest in the determination of effective psychosocial approaches aimed to subjects with mild cognitive impairment (MCI. Recent experimental studies indicate positive effects of cognitive interventions in population with DCL in both, traditional methods and computer based interventions. The present review provides a systematic analysis of the literature in order to assess the effect and scope of actual non-pharmacological cognitive interventions, aimed to older adults with mild cognitive impairment.

  7. PARALLEL SIMULATION OF THE ELLIPTIC MILD SLOPE EQUATION WITH A PERSONAL COMPUTER CLUSTER

    Institute of Scientific and Technical Information of China (English)

    Zheng Yong-hong; You Ya-ge; Wang Li-sheng; Shen Yong-ming

    2003-01-01

    With the massage passing interface, a parallel solution method was proposed for the simulation of the elliptic mild slope equation, and implemented numerically on a parallel system based on a personal computer cluster, which was constructed by the authors. The wave transformations over two typical topographies with mild slopes were simulated. Numerical results show that the parallel solution method presented in this paper can not only increase the computational efficiency, but also decrease very much the memory storage on a single computer, so the parallel system based on a PCC can be used to simulate wave transformations over much larger areas.

  8. Lead-acid batteries for micro- and mild-hybrid applications

    Science.gov (United States)

    Valenciano, J.; Fernández, M.; Trinidad, F.; Sanz, L.

    Car manufactures have announced the launch in coming months of vehicles with reduced emissions due to the introduction of new functions like stop-start and regenerative braking. Initial performance request of automotive lead-acid batteries are becoming more and more demanding and, in addition to this, cycle life with new accelerated ageing profiles are being proposed in order to determine the influence of the new functions on the expected battery life. This paper will show how different lead-acid battery technologies comply with these new demands, from an improved version of the conventional flooded SLI battery to the high performance of spiral wound valve-regulated lead-acid (VRLA) battery. Different approaches have been studied for improving conventional flooded batteries, i.e., either by the addition of new additives for reducing electrolyte stratification or by optimisation of the battery design to extend cycling life in partial state of charge conditions. With respect to VRLA technology, two different battery designs have been compared. Spiral wound design combines excellent power capability and cycle life under different depth of discharge (DoD) cycling conditions, but flat plate design outperform the latter in energy density due to better utilization of the space available in a prismatic enclosure. This latter design is more adequate for high end class vehicles with high electrical energy demand, whereas spiral wound is better suited for high power/long life demand of commercial vehicle. High temperature behaviour (75 °C) is rather poor for both designs due to water loss, and then VRLA batteries should preferably be located out of the engine compartment.

  9. System identification of baroreflex response to mild lower body negative pressure.

    Science.gov (United States)

    Aletti, Federico; Ferrario, Manuela; Xu, Da; Greaves, Danielle K; Shoemaker, Kevin J; Arbeille, Philippe; Cerutti, Sergio; Hughson, Richard L; Baselli, Giuseppe

    2011-01-01

    The effect of mild lower body negative pressure (LBNP) on baroreflex control of arterial blood pressure (ABP) has long been thought to affect cardiopulmonary baroreflex only, although recent studies have pointed out that arterial baroreceptors may be transiently unloaded too after the rapid onset of mild LBNP. This paper presents a spectral decomposition method for the black box identification of the contribution of arterial and cardiopulmonary baroreflexes to beat-by-beat variability of ABP in response to mild LBNP levels. The significant decrease of mean and diastolic arterial pressure and of the arterial baroreflex mediated contribution to overall variability of ABP which was found, suggested that the unloading of arterial baroreceptors may be reflected by an altered dynamic response of arterial baroreflex, too. In addition, arterial baroreflex mediated modulations were found to be the main player in the modulation of beat-by-beat fluctuations of ABP, while the role of cardiopulmonary baroreflex mediated responses appeared to contribute very little.

  10. A Novel Hydrazinecarbothioamide as a Potential Corrosion Inhibitor for Mild Steel in HCl

    Directory of Open Access Journals (Sweden)

    Abu Bakar Mohamad

    2013-04-01

    Full Text Available 2-(1-methyl-4-((E-(2-methylbenzylideneamino-2-phenyl-1H-pyrazol-3(2H-ylidene-hydrazineecarbothioamide (HCB was synthesized as a corrosion inhibitor from the reaction of 4-aminoantipyrine, thiosemicarbazide and 2-methylbenzaldehyde. The corrosion inhibitory effects of HCB on mild steel in 1.0 M HCl were investigated using potentiodynamic polarization (PDP and electrochemical impedance spectroscopy (EIS. The results showed that HCB inhibited mild steel corrosion in acidic solution and inhibition efficiency increased with an increase in the concentration of the inhibitor. The inhibition efficiency was up to 96.5% at 5.0 mM. Changes in the impedance parameters suggested that HCB adsorbed on the surface of mild steel, leading to the formation of a protective film. The novel corrosion inhibitor synthesized in the present study was characterized using Fourier transform infrared spectroscopy (FTIR and nuclear magnetic resonance (NMR spectral data.

  11. Henkin and Hybrid Logic

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Huertas, Antonia; Manzano, Maria;

    2014-01-01

    Leon Henkin was not a modal logician, but there is a branch of modal logic that has been deeply influenced by his work. That branch is hybrid logic, a family of logics that extend orthodox modal logic with special proposition symbols (called nominals) that name worlds. This paper explains why...... Henkin’s techniques are so important in hybrid logic. We do so by proving a completeness result for a hybrid type theory called HTT, probably the strongest hybrid logic that has yet been explored. Our completeness result builds on earlier work with a system called BHTT, or basic hybrid type theory...... is due to the first-order perspective, which lies at the heart of Henin’s best known work and hybrid logic....

  12. Radiological findings in mild forms of Morquio`s disease (MPS 1V A)

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, P.S. [Royal Belfast Hospital for Sick Children (United Kingdom); Nelson, J. [Dept. of Medical Genetics, Royal Victoria Hospital, Belfast (United Kingdom); Nevin, N.C. [Dept. of Medical Genetics, Queen`s Univ., Belfast (United Kingdom)

    1991-11-01

    Clinical and radiological features of seven patients with Morquio`s disease Type A (MPS 1V A) are presented. The diagnosis was established by two-dimensional electrophoresis of the urinary glycosaminoglycans and enzyme assay. The clinical manifestations were mild or moderate in all patients and the radiological changes were milder than those described in classical Morquio`s disease. (orig.)

  13. Gender-Specific Development of Nonverbal Behaviours and Mild Depression in Adolescence

    Science.gov (United States)

    Van Beek, Yolanda; Van Dolderen, Marlies S. M.; Demon Dubas, Judith J. S.

    2006-01-01

    Background: Individual differences in depressive symptoms have been linked with social skill deficits in adults and children, yet empirical studies on adolescents are lacking. The present research examines age and gender differences in nonverbal behaviour between mildly depressed and nondepressed (pre-) adolescents during conversations with an…

  14. Trichloroisocyanuric/TEMPO oxidation of alcohols under mild conditions: a close investigation.

    Science.gov (United States)

    De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea

    2003-06-13

    Efficient oxidation of primary alcohols to the corresponding carboxylic acids can be carried out at room temperature and in acetone/water, using trichloroisocyanuric acid (TCCA) in the presence of catalytic TEMPO. The mild conditions of this procedure and the total absence of any transition metal make this reaction suitable for safe laboratory use. A possible mechanism is presented and discussed.

  15. Self-Reported versus Informant-Reported Depressive Symptoms in Adults with Mild Intellectual Disability

    Science.gov (United States)

    Mileviciute, I.; Hartley, S. L.

    2015-01-01

    Background: Virtually nothing is known about potential differences in the types of depression symptoms reported by adults with mild intellectual disability (ID) on self-reported questionnaires as compared with the types of symptoms reported by caregivers on informant questionnaires. Moreover, little is known about how the presentation of…

  16. On Some Qualitative Properties of Mild Solutions of Nonlocal Semilinear Functional Differential Equations

    Directory of Open Access Journals (Sweden)

    Jain Rupali S.

    2014-12-01

    Full Text Available In the present paper, we investigate the qualitative properties such as existence, uniqueness and continuous dependence on initial data of mild solutions of first and second order nonlocal semilinear functional differential equations with delay in Banach spaces. Our analysis is based on semigroup theory and modified version of Banach contraction theorem.

  17. Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review

    NARCIS (Netherlands)

    Jekel, K.; Damian, M.; Wattmo, C.; Hausner, L.; Bullock, R.; Connelly, P.J.; Dubois, B.; Eriksdotter, M.; Ewers, M.; Graessel, E.; Kramberger, M.G.; Law, E.; Mecocci, P.; Molinuevo, J.L.; Nygard, L.; Olde Rikkert, M.G.M.; Orgogozo, J.M.; Pasquier, F.; Peres, K.; Salmon, E.; Sikkes, S.A.; Sobow, T.; Spiegel, R.; Tsolaki, M.; Winblad, B.; Frolich, L.

    2015-01-01

    INTRODUCTION: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic r

  18. The predictive value of mild renal insufficiency on the prognosis of patients with acute coronary syndrome

    Institute of Scientific and Technical Information of China (English)

    张建华

    2014-01-01

    Objective To investigate the predictive value of mild renal insufficiency on the endpoint events in patients with acute coronary syndrome(ACS).Methods A total of 552 patients with ACS were enrolled in the present study.According to the levels of estimated glomerular filtration rate(eGFR),patients were divided into two groups,normal

  19. A Sequence for Helping Children Having Mild to Moderate Functional Articulation Problems.

    Science.gov (United States)

    Hayek, Robert A.

    Presented are specific sequential procedures for use by paraprofessionals in correcting children's mild to moderate articulation problems. The sequence consists of eight activities to prepare the child for the program, five steps in the area of ear training, and ten steps to teach speech production. Activities and minimum teaching times are…

  20. Early Detection of Depression and Associated Risk Factors in Adults with Mild/Moderate Intellectual Disability

    Science.gov (United States)

    McGillivray, Jane A.; McCabe, Marita P.

    2007-01-01

    The aim of this study was to determine the presentation and risk factors for depression in adults with mild/moderate intellectual disability (ID). A sample of 151 adults (83 males and 68 females) participated in a semi-structured interview. According to results on the Beck Depression Inventory II, 39.1% of participants evinced symptoms of…

  1. Motor Performance of Children with Mild Intellectual Disability and Borderline Intellectual Functioning

    Science.gov (United States)

    Vuijk, P. J.; Hartman, E.; Scherder, E.; Visscher, C.

    2010-01-01

    Background: There is a relatively small body of research on the motor performance of children with mild intellectual disabilities (MID) and borderline intellectual functioning (BIF). Adequate levels of motor skills may contribute to lifelong enjoyment of physical activity, participation in sports and healthy lifestyles. The present study compares…

  2. Using Text-to-Speech Reading Support for an Adult with Mild Aphasia and Cognitive Impairment

    Science.gov (United States)

    Harvey, Judy; Hux, Karen; Snell, Jeffry

    2013-01-01

    This single case study served to examine text-to-speech (TTS) effects on reading rate and comprehension in an individual with mild aphasia and cognitive impairment. Findings showed faster reading, given TTS presented at a normal speaking rate, but no significant comprehension changes. TTS may support reading in people with aphasia when time…

  3. Adapting a Problem-Solving Approach to Teaching Mathematics to Students with Mild Disabilities.

    Science.gov (United States)

    Salend, Spencer J.; Hofstetter, Elaine

    1996-01-01

    Guidelines for implementing a problem-solving approach to teaching mathematics concepts and skills to students with mild disabilities include: establish connections to daily life; use visual presentations; use manipulatives; use peer-mediated instruction; provide models, cues, and prompts; teach self-management techniques and learning strategies;…

  4. Physical activity and executive functions in the elderly with mild cognitive impairment

    NARCIS (Netherlands)

    Scherder, EJA; Van Paasschen, J; Deijen, JB; Van der Knokke, S; Orlebeke, JFK; Burgers, [No Value; Devriese, PP; Swaab, DF; Sergeant, JA

    2005-01-01

    The primary goal of the present study was to examine whether in the elderly with mild cognitive impairment (MCI), the effect of physical activity measured directly following treatment, was reflected in an improvement in cognitive functioning in general or in executive functions (EF) in particular. S

  5. Physical activity and executive functions in the elderly with mild cognitive impairment.

    NARCIS (Netherlands)

    Scherder, E.J.A.; Paasschen, J. van; Deijen, J.-B.; Knokke, S. van der; Orlebeke, J.F.K.; Burgers, I.; DeVriesse, P.-P.; Swaab, D.F.; Sergeant, J.A.

    2005-01-01

    The primary goal of the present study was to examine whether in the elderly with mild cognitive impairment (MCI), the effect of physical activity measured directly following treatment, was reflected in an improvement in cognitive functioning in general or in executive functions (EF) in particular. S

  6. 1997 hybrid electric vehicle specifications

    Energy Technology Data Exchange (ETDEWEB)

    Sluder, S.; Larsen, R.; Duoba, M.

    1996-10-01

    The US DOE sponsors Advanced Vehicle Technology competitions to help educate the public and advance new vehicle technologies. For several years, DOE has provided financial and technical support for the American Tour de Sol. This event showcases electric and hybrid electric vehicles in a road rally across portions of the northeastern United States. The specifications contained in this technical memorandum apply to vehicles that will be entered in the 1997 American Tour de Sol. However, the specifications were prepared to be general enough for use by other teams and individuals interested in developing hybrid electric vehicles. The purpose of the specifications is to ensure that the vehicles developed do not present a safety hazard to the teams that build and drive them or to the judges, sponsors, or public who attend the competitions. The specifications are by no means the definitive sources of information on constructing hybrid electric vehicles - as electric and hybrid vehicles technologies advance, so will the standards and practices for their construction. In some cases, the new standards and practices will make portions of these specifications obsolete.

  7. Comparing Cognitive Profiles of Licensed Drivers with Mild Alzheimer’s Disease and Mild Dementia with Lewy Bodies

    Directory of Open Access Journals (Sweden)

    Stephanie Yamin

    2016-01-01

    Full Text Available Purpose. Alzheimer’s disease (AD and dementia with Lewy Bodies (DLB constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB. Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations. Results. The results showed differences between healthy controls and demented participants on almost all neuropsychological measures. Participants with early DLB were found to perform significantly worse on some measures of attention and visuospatial functioning in comparison with early AD. Discussion. Future research should examine the relationship between neuropsychological measures and driving outcomes among individuals with mild AD and mild DLB.

  8. Mild hyperthermia worsens the neuropathological damage associated with mild traumatic brain injury in rats.

    Science.gov (United States)

    Sakurai, Atsushi; Atkins, Coleen M; Alonso, Ofelia F; Bramlett, Helen M; Dietrich, W Dalton

    2012-01-20

    The effects of slight variations in brain temperature on the pathophysiological consequences of acute brain injury have been extensively described in models of moderate and severe traumatic brain injury (TBI). In contrast, limited information is available regarding the potential consequences of temperature elevations on outcome following mild TBI (mTBI) or concussions. One potential confounding variable with mTBI is the presence of elevated body temperature that occurs in the civilian or military populations due to hot environments combined with exercise or other forms of physical exertion. We therefore determined the histopathological effects of pre- and post-traumatic hyperthermia (39°C) on mTBI. Adult male Sprague-Dawley rats were divided into 3 groups: pre/post-traumatic hyperthermia, post-traumatic hyperthermia alone for 2 h, and normothermia (37°C). The pre/post-hyperthermia group was treated with hyperthermia starting 15 min before mild parasagittal fluid-percussion brain injury (1.4-1.6 atm), with the temperature elevation extending for 2 h after trauma. At 72 h after mTBI, the rats were perfusion-fixed for quantitative histopathological evaluation. Contusion areas and volumes were significantly larger in the pre/post-hyperthermia treatment group compared to the post-hyperthermia and normothermic groups. In addition, pre/post-traumatic hyperthermia caused the most severe loss of NeuN-positive cells in the dentate hilus compared to normothermia. These neuropathological results demonstrate that relatively mild elevations in temperature associated with peri-traumatic events may affect the long-term functional consequences of mTBI. Because individuals exhibiting mildly elevated core temperatures may be predisposed to aggravated brain damage after mTBI or concussion, precautions should be introduced to target this important physiological variable.

  9. BSA Hybrid Synthesized Polymer

    Institute of Scientific and Technical Information of China (English)

    Zong Bin LIU; Xiao Pei DENG; Chang Sheng ZHAO

    2006-01-01

    Bovine serum albumin (BSA), a naturally occurring biopolymer, was regarded as a polymeric material to graft to an acrylic acid (AA)-N-vinyl pyrrolidone (NVP) copolymer to form a biomacromolecular hybrid polymer. The hybrid polymer can be blended with polyethersulfone (PES) to increase the hydrophilicity of the PES membrane, which suggested that the hybrid polymer might have a wide application in the modification of biomaterials.

  10. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Ronkko, Mauno; Ravn, Anders P.

    1997-01-01

    a differential action, which allows differential equations as primitive actions. The extension allows us to model hybrid systems with both continuous and discrete behaviour. The main result of this paper is an extension of such a hybrid action system with parallel composition. The extension does not change...... the original meaning of the parallel composition, and therefore also the ordinary action systems can be composed in parallel with the hybrid action systems....

  11. HYBRID VEHICLE CONTROL SYSTEM

    Directory of Open Access Journals (Sweden)

    V. Dvadnenko

    2016-06-01

    Full Text Available The hybrid vehicle control system includes a start–stop system for an internal combustion engine. The system works in a hybrid mode and normal vehicle operation. To simplify the start–stop system, there were user new possibilities of a hybrid car, which appeared after the conversion. Results of the circuit design of the proposed system of basic blocks are analyzed.

  12. Nanoscale Organic Hybrid Electrolytes

    KAUST Repository

    Nugent, Jennifer L.

    2010-08-20

    Nanoscale organic hybrid electrolytes are composed of organic-inorganic hybrid nanostructures, each with a metal oxide or metallic nanoparticle core densely grafted with an ion-conducting polyethylene glycol corona - doped with lithium salt. These materials form novel solvent-free hybrid electrolytes that are particle-rich, soft glasses at room temperature; yet manifest high ionic conductivity and good electrochemical stability above 5V. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Hybrid radiator cooling system

    Science.gov (United States)

    France, David M.; Smith, David S.; Yu, Wenhua; Routbort, Jules L.

    2016-03-15

    A method and hybrid radiator-cooling apparatus for implementing enhanced radiator-cooling are provided. The hybrid radiator-cooling apparatus includes an air-side finned surface for air cooling; an elongated vertically extending surface extending outwardly from the air-side finned surface on a downstream air-side of the hybrid radiator; and a water supply for selectively providing evaporative cooling with water flow by gravity on the elongated vertically extending surface.

  14. Graphite and Hybrid Nanomaterials as Lubricant Additives

    Directory of Open Access Journals (Sweden)

    Zhenyu J. Zhang

    2014-04-01

    Full Text Available Lubricant additives, based on inorganic nanoparticles coated with organic outer layer, can reduce wear and increase load-carrying capacity of base oil remarkably, indicating the great potential of hybrid nanoparticles as anti-wear and extreme-pressure additives with excellent levels of performance. The organic part in the hybrid materials improves their flexibility and stability, while the inorganic part is responsible for hardness. The relationship between the design parameters of the organic coatings, such as molecular architecture and the lubrication performance, however, remains to be fully elucidated. A survey of current understanding of hybrid nanoparticles as lubricant additives is presented in this review.

  15. A hybrid piezoelectric structure for wearable nanogenerators

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Minbaek; Wang, Sihong; Wang, Zhong Lin [School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (United States); Chen, Chih-Yen [School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (United States); Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013 (China); Cha, Seung Nam; Park, Yong Jun; Kim, Jong Min [Frontier Research Lab, Samsung Advanced Institute of Technology, Samsung Electronics, Gyeonggi-Do 446-712 (Korea, Republic of); Chou, Li-Jen [Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013 (China)

    2012-04-03

    A hybrid-fiber nanogenerator comprising a ZnO nanowire array, PVDF polymer and two electrodes is presented. Depending on the bending or spreading action of the human arm, at an angle of {proportional_to}90 , the hybrid fiber reaches electrical outputs of {proportional_to}0.1 V and {proportional_to}10 nA cm{sup -2}. The unique structure of the hybrid fiber may inspire future research in wearable energy-harvesting technology. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. Hybrid Ceramic Matrix Fibrous Composites: an Overview

    Energy Technology Data Exchange (ETDEWEB)

    Naslain, R, E-mail: naslain@lcts.u-bordeaux1.fr [University of Bordeaux 3, Allee de La Boetie, 33600 Pessac (France)

    2011-10-29

    Ceramic-Matrix Composites (CMCs) consist of a ceramic fiber architecture in a ceramic matrix, bonded together through a thin interphase. The present contribution is limited to non-oxide CMCs. Their constituents being oxidation-prone, they are protected by external coatings. We state here that CMCs display a hybrid feature, when at least one of their components is not homogeneous from a chemical or microstructural standpoint. Hybrid fiber architectures are used to tailor the mechanical or thermal CMC-properties whereas hybrid interphases, matrices and coatings to improve CMC resistance to aggressive environments.

  17. Advanced propulsion system concept for hybrid vehicles

    Science.gov (United States)

    Bhate, S.; Chen, H.; Dochat, G.

    1980-01-01

    A series hybrid system, utilizing a free piston Stirling engine with a linear alternator, and a parallel hybrid system, incorporating a kinematic Stirling engine, are analyzed for various specified reference missions/vehicles ranging from a small two passenger commuter vehicle to a van. Parametric studies for each configuration, detail tradeoff studies to determine engine, battery and system definition, short term energy storage evaluation, and detail life cycle cost studies were performed. Results indicate that the selection of a parallel Stirling engine/electric, hybrid propulsion system can significantly reduce petroleum consumption by 70 percent over present conventional vehicles.

  18. An overview on hybrid active filters

    Energy Technology Data Exchange (ETDEWEB)

    Libano, Fausto B.; Uceda, Javier [Universidad Politecnica de Madrid (Spain). Division de Ingenieria Electronica; Simonetti, Domingos S.L. [Espirito Santo Univ., Vitoria, ES (Brazil). Dept. de Engenharia Eletrica

    1995-12-31

    This paper summarizes the main hybrid filter methods. A special attention is given to series active filter associations. Nowadays, an hybrid filtering is the preferred choice to improve line performance when feeding high-power non-linear loads. In addition, the use of an independent reference frame leads to a better response comparing to the initial proposition of p-q theory. A comparison of possible filter associations is given, presenting the expected function of each one. The work represents an interesting overview on the state-of-the-art of hybrid filters. (author) 16 refs., 8 figs., 2 tabs.

  19. Agronomic and chemical characteristics of hybrid corn to ensiling

    Directory of Open Access Journals (Sweden)

    Flávia Borges de Assis

    2014-12-01

    Full Text Available Our aim was to evaluate agronomic and chemical characteristics of corn hybrids to ensiling. It were evaluated nine corn hybrids (MX 300, RB 9308, 2B655, XB 6012, GNZ 2500, PL6890, PRE 32D10, PRE 22T10 e AG 1051, with three replicates. The higher fresh matter yield were observed in the hybrids PL6890 and PRE 32D10, while the dry matter yield was observed in the hybrid PRE 32D10 (13.43 t ha-1. The hybrids PRE 32D10 and PRE 22T10 stood out to present higher percent of leaf in relation to whole plant, while the lower percent of stems was found in the hybrids MX 300, 2B655 and XB 6012, however the higher leaves: stems relation was found in XB 6012 (0.49. There was higher CP content in the hybrid PRE 32D10 (9.10% of DM, while the lower NDF (57.78% of DM and cellulose content (24.27% of DM were observed in the hybrid GNZ 2500. The hybrid PL6890 presented higher ADF and lignin contents, the others hybrids had values lower. The lower NDIN content was observed in the hybrid RB 9308, while the lower AIDN content occurred on the hybrid 2B655. The lower buffer capacity was observed in the hybrid 2B655 (0.29. There are some differences on chemical composition among the corn hybrids used in this study, however, it is recommended to use the hybrids MX 300, PL6890 and PRE 32D10 for showing higher dry matter yield, which may reflect in the amortization of silage production costs.

  20. Memory complaints in subjective cognitive impairment, amnestic mild cognitive impairment and mild Alzheimer's disease.

    Science.gov (United States)

    Ryu, Seon Young; Lee, Sang Bong; Kim, Tae Woo; Lee, Taek Jun

    2016-12-01

    Memory complaints are a frequent phenomenon in elderly individuals and can lead to opportunistic help-seeking behavior. The aim of this study was to compare different aspects of memory complaints (i.e., prospective versus retrospective complaints) in individuals with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (aMCI), and mild Alzheimer's disease (AD). The study included a total of 115 participants (mean age: 68.82 ± 8.83 years) with SCI (n = 34), aMCI (n = 46), and mild AD (n = 35). Memory complaints were assessed using the Prospective and Retrospective Memory Questionnaire (PRMQ), which consists of 16 items that describe everyday memory failure of both prospective memory (PM) and retrospective memory (RM). For aMCI and AD subjects, informants also completed an informant-rating of the PRMQ. All participants completed detailed neuropsychological tests. Results show that PM complaints were equivalent among the three groups. However, RM complaints differed. Specifically, RM complaints in aMCI were higher than SCI, but similar to AD. Informant-reported memory complaints were higher for AD than aMCI. Our study suggests that RM complaints of memory complaints may be helpful in discriminating between SCI and aMCI, but both PM and RM complaints are of limited value in differentiating aMCI from AD.

  1. Hybrid Unifying Variable Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    In order to compare new phenomenon of topology change,evolution,hybrid ratio and network characteristics of unified hybrid network theoretical model with unified hybrid supernetwork model,this paper constructed unified hybrid variable supernetwork model(HUVSM).The first layer introduces a hybrid ratio dr,the

  2. Large Unifying Hybrid Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    For depicting multi-hybrid process,large unifying hybrid network model(so called LUHNM)has two sub-hybrid ratios except dr.They are deterministic hybrid ratio(so called fd)and random hybrid ratio(so called gr),respectively.

  3. Hybrid Rocket Technology

    National Research Council Canada - National Science Library

    Sankaran Venugopal; K K Rajesh; V Ramanujachari

    2011-01-01

    With their unique operational characteristics, hybrid rockets can potentially provide safer, lower-cost avenues for spacecraft and missiles than the current solid propellant and liquid propellant systems...

  4. Hybrid FOSS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Armstrong researchers are continuing their efforts to further develop FOSS technologies. A hybrid FOSS technique (HyFOSS) employs conventional continuous grating...

  5. Modular and orthogonal synthesis of hybrid polymers and networks.

    Science.gov (United States)

    Liu, Shuang; Dicker, Kevin T; Jia, Xinqiao

    2015-03-28

    Biomaterials scientists strive to develop polymeric materials with distinct chemical make-up, complex molecular architectures, robust mechanical properties and defined biological functions by drawing inspirations from biological systems. Salient features of biological designs include (1) repetitive presentation of basic motifs; and (2) efficient integration of diverse building blocks. Thus, an appealing approach to biomaterials synthesis is to combine synthetic and natural building blocks in a modular fashion employing novel chemical methods. Over the past decade, orthogonal chemistries have become powerful enabling tools for the modular synthesis of advanced biomaterials. These reactions require building blocks with complementary functionalities, occur under mild conditions in the presence of biological molecules and living cells and proceed with high yield and exceptional selectivity. These chemistries have facilitated the construction of complex polymers and networks in a step-growth fashion, allowing facile modulation of materials properties by simple variations of the building blocks. In this review, we first summarize features of several types of orthogonal chemistries. We then discuss recent progress in the synthesis of step growth linear polymers, dendrimers and networks that find application in drug delivery, 3D cell culture and tissue engineering. Overall, orthogonal reactions and modulular synthesis have not only minimized the steps needed for the desired chemical transformations but also maximized the diversity and functionality of the final products. The modular nature of the design, combined with the potential synergistic effect of the hybrid system, will likely result in novel hydrogel matrices with robust structures and defined functions.

  6. Integrated approach for hybrid rocket technology development

    Science.gov (United States)

    Barato, Francesco; Bellomo, Nicolas; Pavarin, Daniele

    2016-11-01

    Hybrid rocket motors tend generally to be simple from a mechanical point of view but difficult to optimize because of their complex and still not well understood cross-coupled physics. This paper addresses the previous issue presenting the integrated approach established at University of Padua to develop hybrid rocket based systems. The methodology tightly combines together system analysis and design, numerical modeling from elementary to sophisticated CFD, and experimental testing done with incremental philosophy. As an example of the approach, the paper presents the experience done in the successful development of a hybrid rocket booster designed for rocket assisted take off operations. It is thought that following the proposed approach and selecting carefully the most promising applications it is possible to finally exploit the major advantages of hybrid rocket motors as safety, simplicity, low cost and reliability.

  7. Mild anemia is frequent and associated with micro‐ and macroangiopathies in patients with type 2 diabetes mellitus

    OpenAIRE

    Ito, Hiroyuki; Takeuchi, Yuichiro; Ishida, Hidenori; Otawa, Aya; Shibayama, Akane; Antoku,Shinichi; Abe, Mariko; Mifune, Mizuo; Togane, Michiko

    2010-01-01

    Abstract Aims/Introduction:  The present study investigated the frequency of mild anemia, which is not an indication of intensive therapy using drugs, in Japanese patients with type 2 diabetes mellitus and the association of mild anemia with diabetic complications. Materials and Methods:  This is a cross‐sectional study of 1189 patients with type 2 diabetes mellitus. Anemia was defined as a hemoglobin level

  8. The interrelation between plus-hybrid effect on grain yield and genetic distance of studied hybrids

    Directory of Open Access Journals (Sweden)

    Božinović Sofija

    2010-01-01

    Full Text Available The combined effect of cytoplasmic male sterility and xenia is referred to as the Plus-Hybrid effect. A mixture of hybrids, in which one is a sterile female component and the other is a fertile pollinator, was sown. The objective of the present study was to determine whether the increase of a hybrid genetic distance would result in the increased gain from Plus-hybrid effects on grain yield. Two ZP hybrids (ZP 1 and ZP 2, i.e. their sterile and fertile counterparts, as well as, five hybrid pollinators (ZP 1, ZP 2, ZP 3, ZP 4 and ZP 5 were selected for the studies. The three-replicate trail was set up according to the randomized split-plot design at Zemun Polje in 2009. SSR markers were used to determine the genetic distance between hybrids. Ten out of total 12 applied primers gave results. Coefficients of similarity were estimated according to Dice and Jaccard. The greatest (0.37, i.e. smallest genetic distance (0.08, according to Dice, was obtained between hybrids ZP 1 and ZP 5, i.e. ZP 1 and ZP 4, respectively. Values of genetic distance according to Jaccard were between 0.14 (ZP 1 and ZP 4 and 0.54 (ZP 1 i ZP 5 . By using the cluster analysis, four hybrids (ZP 1, ZP 4, ZP 3 and ZP 2 were grouped into one sub-cluster that was loosely linked to ZP 5. The Plus-hybrid effect on grain yield of the hybrid ZP 1 was negative. The greatest gain was detected in the ZP 2st ' ZP 1 combination, between two hybrids that were genetically very similar and belonged to the same sub-cluster, and then in ZP 2st x ZP 3 and ZP 2st x ZP 4 combinations, between hybrids that also belonged to the same sub-cluster. It can be concluded that the Plus-hybrid effect, after all, depends not on the hybrid genetic distance but on the hybrid genotype.

  9. From hybrid swarms to swarms of hybrids

    Science.gov (United States)

    Stohlgren, Thomas J.; Szalanski, Allen L; Gaskin, John F.; Young, Nicholas E.; West, Amanda; Jarnevich, Catherine S.; Tripodi, Amber

    2015-01-01

    Science has shown that the introgression or hybridization of modern humans (Homo sapiens) with Neanderthals up to 40,000 YBP may have led to the swarm of modern humans on earth. However, there is little doubt that modern trade and transportation in support of the humans has continued to introduce additional species, genotypes, and hybrids to every country on the globe. We assessed the utility of species distributions modeling of genotypes to assess the risk of current and future invaders. We evaluated 93 locations of the genus Tamarix for which genetic data were available. Maxent models of habitat suitability showed that the hybrid, T. ramosissima x T. chinensis, was slightly greater than the parent taxa (AUCs > 0.83). General linear models of Africanized honey bees, a hybrid cross of Tanzanian Apis mellifera scutellata and a variety of European honey bee including A. m. ligustica, showed that the Africanized bees (AUC = 0.81) may be displacing European honey bees (AUC > 0.76) over large areas of the southwestern U.S. More important, Maxent modeling of sub-populations (A1 and A26 mitotypes based on mDNA) could be accurately modeled (AUC > 0.9), and they responded differently to environmental drivers. This suggests that rapid evolutionary change may be underway in the Africanized bees, allowing the bees to spread into new areas and extending their total range. Protecting native species and ecosystems may benefit from risk maps of harmful invasive species, hybrids, and genotypes.

  10. THE USE OF GENETIC ALGORITHM IN DIMENSIONING HYBRID AUTONOMOUS SYSTEMS

    Directory of Open Access Journals (Sweden)

    RUS T.

    2016-03-01

    Full Text Available In this paper is presented the working principle of genetic algorithms used to dimension autonomous hybrid systems. It is presented a study case in which is dimensioned and optimized an autonomous hybrid system for a residential house located in Cluj-Napoca. After the autonomous hybrid system optimization is performed, it is achieved a reduction of the total cost of system investment, a reduction of energy produced in excess and a reduction of CO2 emissions.

  11. Performance of hybrid photovoltaic collector

    OpenAIRE

    Garbisu Eugui, Josu

    2010-01-01

    The aim of the present project is the study of the performance of a combined photovoltaic-thermal plant, called also hybrid system, located in south Italy, evaluating the efficiency of the photovoltaic and thermal systems and the advantage respect to the two single plants (photovoltaic and thermal ). This research project has two objectives fundamentals of efficiency improvement energy from solar photovoltaic panels. On one hand, increase photovoltaic efficiency, at the same time an...

  12. Hybrid and hierarchical composite materials

    CERN Document Server

    Kim, Chang-Soo; Sano, Tomoko

    2015-01-01

    This book addresses a broad spectrum of areas in both hybrid materials and hierarchical composites, including recent development of processing technologies, structural designs, modern computer simulation techniques, and the relationships between the processing-structure-property-performance. Each topic is introduced at length with numerous  and detailed examples and over 150 illustrations.   In addition, the authors present a method of categorizing these materials, so that representative examples of all material classes are discussed.

  13. Ductility Performance of Hybrid Fibre Reinforced Concrete

    OpenAIRE

    S. Eswari; P.N. Raghunath; Suguna, K

    2008-01-01

    This study presents a study on the ductility performance of hybrid fibre reinforced concrete. The influence of fibre content on the ductility performance of hybrid fibre reinforced concrete specimens having different fibre volume fractions was investigated. The parameters of investigation included modulus of rupture, ultimate load, service load, ultimate and service load deflection, crack width, energy ductility and deflection ductility. A total of 27 specimens, 100×100×500 mm, were tested to...

  14. Power Quality Application of Hybrid Drivetrain

    OpenAIRE

    Rassõlkin, Anton; Hõimoja, Hardi

    2012-01-01

    This paper presents a study on the power conditioning features of hybrid powertrain, especially regarding diesel-electric locomotives. Equipped with an embarked energy buffer for diesel generator support and utility grid interface, such a locomotive can be considered as a plug-in series hybrid vehicle. The driveline inductive components, like generator and motor windings, and capacitive components like dc link capacitors can be used to provide STATCOM functions, and the energy buffer can be u...

  15. Boltzmann Transport in Hybrid PIC HET Modeling

    Science.gov (United States)

    2015-07-01

    Paper 3. DATES COVERED (From - To) July 2015-July 2015 4. TITLE AND SUBTITLE Boltzmann transport in hybrid PIC HET modeling 5a. CONTRACT NUMBER In...produced a variety of self-consistent electron swarm codes, such as the Magboltz code, focused on directly solving the steady Boltzmann trans-port...Std. 239.18 Boltzmann transport in hybrid PIC HET modeling IEPC-2015- /ISTS-2015-b- Presented at Joint Conference of 30th International

  16. Statistical Model Checking for Stochastic Hybrid Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Du, Dehui; Larsen, Kim Guldstrand

    2012-01-01

    This paper presents novel extensions and applications of the UPPAAL-SMC model checker. The extensions allow for statistical model checking of stochastic hybrid systems. We show how our race-based stochastic semantics extends to networks of hybrid systems, and indicate the integration technique...... applied for implementing this semantics in the UPPAAL-SMC simulation engine. We report on two applications of the resulting tool-set coming from systems biology and energy aware buildings....

  17. Collective identity formation in hybrid organizations.

    OpenAIRE

    Boulongne, Romain; Boxenbaum, Eva

    2015-01-01

    International audience; The present article examines the process of collective identity formation in the context of hybrid organizing. Empirically, we investigate hybrid organizing in a collaborative structure at the interface of two heterogeneous organizations in the domain of new renewable energies. We draw on the literature on knowledge sharing across organizational boundaries, particularly the notions of transfer, translation and transformation, to examine in real time how knowledge shari...

  18. Graphene Hybrid Materials in Gas Sensing Applications

    Directory of Open Access Journals (Sweden)

    Usman Latif

    2015-12-01

    Full Text Available Graphene, a two dimensional structure of carbon atoms, has been widely used as a material for gas sensing applications because of its large surface area, excellent conductivity, and ease of functionalization. This article reviews the most recent advances in graphene hybrid materials developed for gas sensing applications. In this review, synthetic approaches to fabricate graphene sensors, the nano structures of hybrid materials, and their sensing mechanism are presented. Future perspectives of this rapidly growing field are also discussed.

  19. A Mathematical Model for Suppression Subtractive Hybridization

    OpenAIRE

    2002-01-01

    Suppression subtractive hybridization (SSH) is frequently used to unearth differentially expressed genes on a whole-genome scale. Its versatility is based on combining cDNA library subtraction and normalization, which allows the isolation of sequences of varying degrees of abundance and differential expression. SSH is a complex process with many adjustable parameters that affect the outcome of gene isolation.We present a mathematical model of SSH based on DNA hybridization kinetics for assess...

  20. Cryopreservation of Bituminaria bituminosa varieties and hybrids

    OpenAIRE

    Gisbert Domenech, Maria Carmen; Dabauza, Mercedes; Correal, Enrique; Swennen, Rony; Panis, Bart

    2015-01-01

    [EN] Bituminaria bituminosa (L.) C.H. Stirton is a drought tolerant, perennial legume pasture species and a source of pharmaceutical compounds. Bituminaria breeding programs aim to develop and conserve hybrids with desirable traits such as high forage quality, tolerance to biotic or abiotic stresses, and high contents of furanocoumarins. In this work we present a cryopreservation study of different B. bituminosa accessions: two varieties and eight intervarietal hybrids resulting f...

  1. 7 CFR 201.11a - Hybrid.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Hybrid. 201.11a Section 201.11a Agriculture... REGULATIONS Labeling Agricultural Seeds § 201.11a Hybrid. If any one kind or kind and variety of seed present in excess of 5 percent is “hybrid” seed, it shall be designated “hybrid” on the label. The...

  2. Mild-split SUSY with flavor

    CERN Document Server

    Eliaz, Latif; Gudnason, Sven Bjarke; Tsuk, Eitan

    2013-01-01

    In the framework of a gauge mediated quiver-like model, the standard model flavor texture can be naturally generated. The model - like the MSSM - has furthermore a region in parameter space where the lightest Higgs mass is fed by heavy stop loops, which in turn sets the average squark mass scale near 10-20 TeV. We perform a careful flavor analysis to check whether this type of mild-split SUSY passes all flavor constraints as easily as envisioned in the original type of split SUSY. Interestingly, it turns out to be on the border of several constraints, in particular, the branching ratio of mu -> e gamma and, if order one complex phases are assumed, also epsilon_K neutron and electron EDM. Furthermore, we consider unification as well as dark matter candidates, especially the gravitino. Finally, we provide a closed-form formula for the soft masses of matter in arbitrary representations of any of the gauge groups in a generic quiver-like model with a general messenger sector.

  3. Probabilistic Sequence Learning in Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Dezso eNemeth

    2013-07-01

    Full Text Available Mild Cognitive Impairment (MCI causes slight but noticeable disruption in cognitive systems, primarily executive and memory functions. However, it is not clear if the development of sequence learning is affected by an impaired cognitive system and, if so, how. The goal of our study was to investigate the development of probabilistic sequence learning, from the initial acquisition to consolidation, in MCI and healthy elderly control groups. We used the Alternating Serial Reaction Time task (ASRT to measure probabilistic sequence learning. Individuals with MCI showed weaker learning performance than the healthy elderly group. However, using the reaction times only from the second half of each learning block – after the reactivation phase - we found intact learning in MCI. Based on the assumption that the first part of each learning block is related to reactivation/recall processes, we suggest that these processes are affected in MCI. The 24-hour offline period showed no effect on sequence-specific learning in either group but did on general skill learning: the healthy elderly group showed offline improvement in general reaction times while individuals with MCI did not. Our findings deepen our understanding regarding the underlying mechanisms and time course of sequence acquisition and consolidation.

  4. Mild dehydration affects mood in healthy young women.

    Science.gov (United States)

    Armstrong, Lawrence E; Ganio, Matthew S; Casa, Douglas J; Lee, Elaine C; McDermott, Brendon P; Klau, Jennifer F; Jimenez, Liliana; Le Bellego, Laurent; Chevillotte, Emmanuel; Lieberman, Harris R

    2012-02-01

    Limited information is available regarding the effects of mild dehydration on cognitive function. Therefore, mild dehydration was produced by intermittent moderate exercise without hyperthermia and its effects on cognitive function of women were investigated. Twenty-five females (age 23.0 ± 0.6 y) participated in three 8-h, placebo-controlled experiments involving a different hydration state each day: exercise-induced dehydration with no diuretic (DN), exercise-induced dehydration plus diuretic (DD; furosemide, 40 mg), and euhydration (EU). Cognitive performance, mood, and symptoms of dehydration were assessed during each experiment, 3 times at rest and during each of 3 exercise sessions. The DN and DD trials in which a volunteer attained a ≥1% level of dehydration were pooled and compared to that volunteer's equivalent EU trials. Mean dehydration achieved during these DN and DD trials was -1.36 ± 0.16% of body mass. Significant adverse effects of dehydration were present at rest and during exercise for vigor-activity, fatigue-inertia, and total mood disturbance scores of the Profile of Mood States and for task difficulty, concentration, and headache as assessed by questionnaire. Most aspects of cognitive performance were not affected by dehydration. Serum osmolality, a marker of hydration, was greater in the mean of the dehydrated trials in which a ≥1% level of dehydration was achieved (P = 0.006) compared to EU. In conclusion, degraded mood, increased perception of task difficulty, lower concentration, and headache symptoms resulted from 1.36% dehydration in females. Increased emphasis on optimal hydration is warranted, especially during and after moderate exercise.

  5. Efficacy of psychosocial intervention in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Waldorff, F B; Buss, D V; Eckermann, A

    2012-01-01

    To assess the efficacy at 12 months of an early psychosocial counselling and support programme for outpatients with mild Alzheimer's disease and their primary care givers.......To assess the efficacy at 12 months of an early psychosocial counselling and support programme for outpatients with mild Alzheimer's disease and their primary care givers....

  6. The transition of mild to severe wear of ceramics

    NARCIS (Netherlands)

    Pasaribu, H.R.; Sloetjes, J.W.; Schipper, D.J.

    2004-01-01

    The transition of mild to severe wear of ceramics depends on the operating conditions (normal load, velocity and temperature) and material properties (like grain size, mechanical and thermal material properties). Adachi et al. [Wear 203¿204 (1997) 291] introduced the transition of mild to severe wea

  7. Modeling and Analysis of Hybrid Dynamic Systems Using Hybrid Petri Nets

    OpenAIRE

    GHOMRI Latefa; Alla, Hassane

    2008-01-01

    Some extensions of PNs permitting HDS modeling were presented here. The first models to be presented are continuous PNs. This model may be used for modeling either a continuous system or a discrete system. In this case, it is an approximation that is often satisfactory. Hybrid PNs combine in the same formalism a discrete PN and a continuous PN. Two hybrid PN models were considered in this chapter. The first, called the hybrid PN, has a deterministic behavior; this means that we can predict th...

  8. Cardiac hybrid imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gaemperli, Oliver [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University Hospital Zurich, Nuclear Cardiology, Cardiovascular Center, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); Alkadhi, Hatem [University Hospital Zurich, Institute of Diagnostic and Interventional Radiology, Zurich (Switzerland)

    2014-05-15

    Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In coronary artery disease (CAD), hybrid SPECT/CT imaging allows detection of coronary artery stenosis and myocardial perfusion abnormalities. The clinical value of hybrid imaging has been documented in several subsets of patients. In selected groups of patients, hybrid imaging improves the diagnostic accuracy to detect CAD compared to the single imaging techniques. Additionally, this approach facilitates functional interrogation of coronary stenoses and guidance with regard to revascularization procedures. Moreover, the anatomical information obtained from CT coronary angiography or coronary artery calcium scores (CACS) adds prognostic information over perfusion data from SPECT. The use of cardiac hybrid imaging has been favoured by the dissemination of dedicated hybrid systems and the release of dedicated image fusion software, which allow simple patient throughput for hybrid SPECT/CT studies. Further technological improvements such as more efficient detector technology to allow for low-radiation protocols, ultra-fast image acquisition and improved low-noise image reconstruction algorithms will be instrumental to further promote hybrid SPECT/CT in research and clinical practice. (orig.)

  9. A Hybrid Imagination

    DEFF Research Database (Denmark)

    Jamison, Andrew; Christensen, Steen Hyldgaard; Botin, Lars

    contexts, or sites, for mixing scientific knowledge and technical skills from different fields and social domains into new combinations, thus fostering what the authors term a “hybrid imagination”. Such a hybrid imagination is especially important today, as a way to counter the competitive and commercial...

  10. Fatigue reliability based on residual strength model with hybrid uncertain parameters

    Institute of Scientific and Technical Information of China (English)

    Jun Wang; Zhi-Ping Qiu

    2012-01-01

    The aim of this paper is to evaluate the fatigue reliability with hybrid uncertain parameters based on a residual strength model.By solving the non-probabilistic setbased reliability problem and analyzing the reliability with randomness,the fatigue reliability with hybrid parameters can be obtained.The presented hybrid model can adequately consider all uncertainties affecting the fatigue reliability with hybrid uncertain parameters.A comparison among the presented hybrid model,non-probabilistic set-theoretic model and the conventional random model is made through two typical numerical examples.The results show that the presented hybrid model,which can ensure structural security,is effective and practical.

  11. Hybrid reactors. [Fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    Moir, R.W.

    1980-09-09

    The rationale for hybrid fusion-fission reactors is the production of fissile fuel for fission reactors. A new class of reactor, the fission-suppressed hybrid promises unusually good safety features as well as the ability to support 25 light-water reactors of the same nuclear power rating, or even more high-conversion-ratio reactors such as the heavy-water type. One 4000-MW nuclear hybrid can produce 7200 kg of /sup 233/U per year. To obtain good economics, injector efficiency times plasma gain (eta/sub i/Q) should be greater than 2, the wall load should be greater than 1 MW.m/sup -2/, and the hybrid should cost less than 6 times the cost of a light-water reactor. Introduction rates for the fission-suppressed hybrid are usually rapid.

  12. Hybrid propulsion technology program

    Science.gov (United States)

    1990-01-01

    Technology was identified which will enable application of hybrid propulsion to manned and unmanned space launch vehicles. Two design concepts are proposed. The first is a hybrid propulsion system using the classical method of regression (classical hybrid) resulting from the flow of oxidizer across a fuel grain surface. The second system uses a self-sustaining gas generator (gas generator hybrid) to produce a fuel rich exhaust that was mixed with oxidizer in a separate combustor. Both systems offer cost and reliability improvement over the existing solid rocket booster and proposed liquid boosters. The designs were evaluated using life cycle cost and reliability. The program consisted of: (1) identification and evaluation of candidate oxidizers and fuels; (2) preliminary evaluation of booster design concepts; (3) preparation of a detailed point design including life cycle costs and reliability analyses; (4) identification of those hybrid specific technologies needing improvement; and (5) preperation of a technology acquisition plan and large scale demonstration plan.

  13. Hybrid Dislocated Control and General Hybrid Projective Dislocated Synchronization for Memristor Chaotic Oscillator System

    Directory of Open Access Journals (Sweden)

    Junwei Sun

    2014-01-01

    Full Text Available Some important dynamical properties of the memristor chaotic oscillator system have been studied in the paper. A novel hybrid dislocated control method and a general hybrid projective dislocated synchronization scheme have been realized for memristor chaotic oscillator system. The paper firstly presents hybrid dislocated control method for stabilizing chaos to the unstable equilibrium point. Based on the Lyapunov stability theorem, general hybrid projective dislocated synchronization has been studied for the drive memristor chaotic oscillator system and the same response memristor chaotic oscillator system. For the different dimensions, the memristor chaotic oscillator system and the other chaotic system have realized general hybrid projective dislocated synchronization. Numerical simulations are given to show the effectiveness of these methods.

  14. Hearing preservation with a hybrid cochlear implant (electro-acoustic stimulation – case report

    Directory of Open Access Journals (Sweden)

    Janez Rebol

    2014-01-01

    Full Text Available Typical preoperative hearing loss of candidates for a hybrid cochlear implant ranges from mild to moderate hearing loss in the low frequencies (up to 500 Hz and severe to profound hearing loss in the mid and high frequencies (above 1500 Hz. Usually, the patients have limited or no benefit from hearing aids and their word discrimination score is between 10–60 %. These patients often do not use the hearing aids at all, because they do not hear well in the middle and high frequencies.This 8-year old boy presented with symetrical hearing loss, which was profound in middle and high frequencies and moderate in low frequencies. Because of that, his speech development was impaired. We inserted a hybrid cochlear implant with a hearing preservation electrode by atraumatic insertion technique through the round window and succeeded to preserve his residual hearing. He adapted well to the use of hearing aid and cochlear implant and significantly improved understanding of the high frequency words and sentences.

  15. Massive primordial black holes from hybrid inflation as dark matter and the seeds of galaxies

    Science.gov (United States)

    Clesse, Sébastien; García-Bellido, Juan

    2015-07-01

    In this paper we present a new scenario where massive primordial black holes (PBHs) are produced from the collapse of large curvature perturbations generated during a mild-waterfall phase of hybrid inflation. We determine the values of the inflaton potential parameters leading to a PBH mass spectrum peaking on planetarylike masses at matter-radiation equality and producing abundances comparable to those of dark matter today, while the matter power spectrum on scales probed by cosmic microwave background (CMB) anisotropies agrees with Planck data. These PBHs could have acquired large stellar masses today, via merging, and the model passes both the constraints from CMB distortions and microlensing. This scenario is supported by Chandra observations of numerous BH candidates in the central region of Andromeda. Moreover, the tail of the PBH mass distribution could be responsible for the seeds of supermassive black holes at the center of galaxies, as well as for ultraluminous x-ray sources. We find that our effective hybrid potential can originate e.g. from D-term inflation with a Fayet-Iliopoulos term of the order of the Planck scale but sub-Planckian values of the inflaton field. Finally, we discuss the implications of quantum diffusion at the instability point of the potential, able to generate a Swiss-cheese-like structure of the Universe, eventually leading to apparent accelerated cosmic expansion.

  16. Hybrid dynamical systems observation and control

    CERN Document Server

    Defoort, Michael

    2015-01-01

    This book is a collection of contributions defining the state of current knowledge and new trends in hybrid systems – systems involving both continuous dynamics and discrete events – as described by the work of several well-known groups of researchers. Hybrid Dynamical Systems presents theoretical advances in such areas as diagnosability, observability and stabilization for various classes of system. Continuous and discrete state estimation and self-triggering control of nonlinear systems are advanced. The text employs various methods, among them, high-order sliding modes, Takagi–Sugeno representation and sampled-data switching to achieve its ends. The many applications of hybrid systems from power converters to computer science are not forgotten; studies of flexible-joint robotic arms and – as representative biological systems – the behaviour of the human heart and vasculature, demonstrate the wide-ranging practical significance of control in hybrid systems. The cross-disciplinary origins of study ...

  17. The path exchange method for hybrid LCA.

    Science.gov (United States)

    Lenzen, Manfred; Crawford, Robert

    2009-11-01

    Hybrid techniques for Life-Cycle Assessment (LCA) provide a way of combining the accuracy of process analysis and the completeness of input-output analysis. A number of methods have been suggested to implement a hybrid LCA in practice, with the main challenge being the integration of specific process data with an overarching input-output system. In this work we present a new hybrid LCA method which works at the finest input-output level of detail: structural paths. This new Path Exchange method avoids double-counting and system disturbance just as previous hybrid LCA methods, but instead of a large LCA database it requires only a minimum of external information on those structural paths that are to be represented by process data.

  18. Hybrid Pulsators -- Pulsating Stars with Multiple Identities

    CERN Document Server

    Zhou, A -Y

    2015-01-01

    We have carried out a statistic survey on the pulsating variable stars with multiple identities. These stars were identified to exhibit two types of pulsation or multiple light variability types in the literature, and are usually called hybrid pulsators. We extracted the hybrid information based on the Simbad database. Actually, all the variables with multiple identities are retrieved. The survey covers various pulsating stars across the Hertzsprung-Russell diagram. We aim at giving a clue in selecting interesting targets for further observation. Hybrid pulsators are excellent targets for asteroseismology. An important implication of such stars is their potential in advancing the theories of both stellar evolution and pulsation. By presenting the statistics, we address the open questions and prospects regarding current status of hybrid pulsation studies.

  19. Design of Digital Hybrid Chaotic Sequence Generator

    Institute of Scientific and Technical Information of China (English)

    RAO Nini; ZENG Dong

    2004-01-01

    The feasibility of the hybrid chaotic sequences as the spreading codes in code divided multiple access(CDMA) system is analyzed.The design and realization of the digital hybrid chaotic sequence generator by very high speed integrated circuit hardware description language(VHDL) are described.A valid hazard canceledl method is presented.Computer simulations show that the stable digital sequence waveforms can be produced.The correlations of the digital hybrid chaotic sequences are compared with those of m-sequences.The results show that the correlations of the digital hybrid chaotic sequences are almost as good as those of m-sequences.The works in this paper explored a road for the practical applications of chaos.

  20. Thermal stability of PMMA–clay hybrids

    Indian Academy of Sciences (India)

    Tanushree Choudhury; Nirendra M Misra

    2010-04-01

    Materials with small particle size are being extensively used in composites and hybrid materials. Exfoliated clay–polymer hybrids show enhanced properties. Exfoliation of clay platelets can be affected by selecting dispersing agents. In the present work, clay dispersed by natural dispersant (soap stone powder), cetyl trimethyl ammonium bromide (CTAB) dispersed clay and acid clay (amorphous clay) are taken. They are then polymerized with poly methyl methacrylate (PMMA) by solution intercalation method. The thermal stability of these different clay–PMMA hybrids have been studied and compared with that of pure PMMA by differential scanning calorimeter (DSC). The bonding of clay with PMMA has been studied by IR. Morphology of clay–PMMA hybrids has been shown by SEM and XRD which indicate partially exfoliated structure in T606-4 and intercalated structures in T606-6 and T606-2.

  1. Hybrid neural network models of transducers

    Science.gov (United States)

    Xie, Shilin; Zhang, Xinong; Chen, Shenglai; Zhu, Changchun

    2011-10-01

    A hybrid neural network (NN) approach is proposed and applied to modeling of transducers in the paper. The modeling procedures are also presented in detail. First, the simulated studies on the modeling of single input-single output and multi input-multi output transducers are conducted respectively by use of the developed hybrid NN scheme. Secondly, the hybrid NN modeling approach is utilized to characterize a six-axis force sensor prototype based on the measured data. The results show that the hybrid NN approach can significantly improve modeling precision in comparison with the conventional modeling method. In addition, the method is superior to NN black-box modeling because the former possesses smaller network scale, higher convergence speed, higher model precision and better generalization performance.

  2. Recent Advances on Hybrid Intelligent Systems

    CERN Document Server

    Melin, Patricia; Kacprzyk, Janusz

    2013-01-01

    This book presents recent advances on hybrid intelligent systems using soft computing techniques for intelligent control and robotics, pattern recognition, time series prediction and optimization of complex problems. Soft Computing (SC) consists of several intelligent computing paradigms, including fuzzy logic, neural networks, and bio-inspired optimization algorithms, which can be used to produce powerful hybrid intelligent systems. The book is organized in five main parts, which contain groups of papers around a similar subject. The first part consists of papers with the main theme of hybrid intelligent systems for control and robotics, which are basically state of the art papers that propose new models and concepts, which can be the basis for achieving intelligent control and mobile robotics. The second part contains papers with the main theme of hybrid intelligent systems for pattern recognition and time series prediction, which are basically papers using nature-inspired techniques, like evolutionary algo...

  3. Prospects for Hybrid Breeding in Bioenergy Grasses

    DEFF Research Database (Denmark)

    Aguirre, Andrea Arias; Studer, Bruno; Frei, Ursula

    2012-01-01

    of different hybrid breeding schemes to optimally exploit heterosis for biomass yield in perennial ryegrass (Lolium perenne L.) and switchgrass (Panicum virgatum), two perennial model grass species for bioenergy production. Starting with a careful evaluation of current population and synthetic breeding methods......, we address crucial topics to implement hybrid breeding, such as the availability and development of heterotic groups, as well as biological mechanisms for hybridization control such as self-incompatibility (SI) and male sterility (MS). Finally, we present potential hybrid breeding schemes based on SI...... and MS for the two bioenergy grass species, and discuss how molecular tools and synteny can be used to transfer relevant information for genes controlling these biological mechanisms across grass species...

  4. Segmented Hybrid Gasostatic Bearing Optimization

    Directory of Open Access Journals (Sweden)

    Prodan Nikolay Vasilevich

    2014-07-01

    Full Text Available The purpose of research-development of methods of numerical optimization rotatable support pads gasostatic hybrid bearing. In the world‘s aerospace engineering the gas-dynamic bearings are currently most common. They are characterized by the supporting layer of different designs, which ensures the workability of the rotors during starts and stops. The main problem of this bearing type, apart from the construction complexity is the wear of this supporting layer. Gas-static bearing has no such defect, since there is no physical contact between solid surfaces. This study presents the results of the hybrid bearing’s calculation, combining both technologies. The slotted nozzle of non-conventional shape that mirrors the solution of Reynolds equation’s isoline is studied. The dependences of the main parameters on the speed of the shaft’s rotation are discussed. The aerodynamic resistance of pads for different regimes of operation is investigated.

  5. Hybrid Adaptive Observer for a Brushless DC Motor

    DEFF Research Database (Denmark)

    Niemczyk, Piotr; Porchez, Thomas; Bendtsen, Jan Dimon

    2008-01-01

    A novel hybrid adaptive observer for Brushless DC Motors (BLDCM) is presented. It uses two current measurements of BLDCM phases to estimate the angle and the speed of the rotor. The observer is designed on the basis of a hybrid model, which is also presented in this paper. The parameters...

  6. A Future with Hybrid Electric Propulsion Systems: A NASA Perspective

    Science.gov (United States)

    DelRosario, Ruben

    2014-01-01

    The presentation highlights a NASA perspective on Hybrid Electric Propulsion Systems for aeronautical applications. Discussed are results from NASA Advance Concepts Study for Aircraft Entering service in 2030 and beyond and the potential use of hybrid electric propulsion systems as a potential solution to the requirements for energy efficiency and environmental compatibility. Current progress and notional potential NASA research plans are presented.

  7. A Hybrid Model of a Brushless DC Motor

    DEFF Research Database (Denmark)

    Bendtsen, Jan Dimon; Hansen, Hans Brink; Kallesøe, Carsten Skovmose

    2007-01-01

    This paper presents a novel approach to modeling of a Brush-Less Direct Current Motor (BLDCM) driven by an inverter using hybrid systems theory. Hybrid systems combine continuous and discrete (event-based) dynamics, which is exactly the case in an inverter-driven BLDCM. The model presented in thi...

  8. Hybride textuelle Strukturen und hybride textuelle Einheiten. Ein Beitrag zur Theorie der Wörterbuchform

    Directory of Open Access Journals (Sweden)

    Herbert Ernst Wiegand

    2011-10-01

    Textsegmentklassen aufweisen (vgl. die Stichwörter.

    Stichwörter: ANGABERELATION, ELEMENTENHETEROGENE TRÄGERMENGE, FUNKTIONALER ANGABEZUSATZ, FUNKTIONAL-POSITIONALE SEGMENTATION, HIERARCHISCHE ARCHITEKTONISCH ANGEREICHERTE ARTIKELMIKROSTRUKTUR, HIERARCHISCHE HYBRIDE ANGABENKONSTITUENTENSTRUKTUR MIT GLOSSATBEDINGTER TEILSTRUKTUR, HIERARCHISCHE HYBRIDE ANGABENSTRUKTUR, HIERARCHISCHE HYBRIDE ARTIKELKONSTITUENTENSTRUKTUR, HIERARCHISCHE HYBRIDE ARTIKELMIKROSTRUKTUR, HIERARCHISCHE HYBRIDE EXHAUSTIVE ANGABENSTRUKTUR, HIERARCHISCHE HYBRIDE GLOSSATBEDINGTE ANGABESTRUKTUR, HIERARCHISCHE HYBRIDE FLACHE DOPPELGLOSSATBEDINGTE ANGABESTRUKTUR, HIERARCHISCHE HYBRIDE MINIMIERTE GLOSSATBEDINGTE ANGABESTRUKTUR, HIERARCHISCHE HYBRIDE TEXTKONSTITUENTENSTRUKTUR, HIERARCHISCHE HYBRIDE TIEFE DOPPELGLOSSATBEDINGTE ANGABESTRUKTUR, HIERARCHISCHE REINE TEXTKONSTITUENTENSTRUKTUR, HYBRIDE VERWEISKENNZEICHNUNG, NICHTFUNKTIONALE-POSITIONALE SEGMENTATION, ORDNUNGSRELATION, SEGMENTATIVE ISOLIERUNG, VERTIKALE ANGABEARCHITEKTUR

     

    ABSTRACT: Hybrid textual structures and hybrid textual units. A contribution to the theory of dictionary structures. In this contribution, the formation, presentation and performance of hybrid textual structures that display accessible entries are discussed by using examples from dictionary articles. The features of hybrid textual units are also explained. A dictionary article in a printed dictionary always displays both a hierarchical pure and a hierarchical hybrid text constituent structure, when it contains at least one functional item addition, e.g. an upward- or downward- or an internally-expanded one. Because functional item additions are text segments with an item function but without text constituent status, they are enabled by means of non-functional segmentation, so that both functional and non-functional text segments prevail. During the formation of structures they then enter the structure-carrying set so that the structurecarrying set of all hybrid

  9. S 400 BlueHYBRID. First hybrid vehicle with Li-ion technology; S 400 BlueHYBRID. Erstes Hybridfahrzeug mit Li-Ionen-Technologie

    Energy Technology Data Exchange (ETDEWEB)

    Vollrath, Oliver; Armstrong, Neil; Schenk, Juergen; Bitsche, Otmar; Lamm, Arnold [Daimler AG, Stuttgart (Germany)

    2009-07-01

    Mercedes Benz advances the electrification of the drive strand in all performance classes and in all models from the start-stop system till to the full hybrid. Thereby, the S 400 BlueHYBRID presents the first Mercedes-Benz hybrid. Equipped with the characteristics of a start-stop system, with a recovery of the brake energy and with an electrical support of the drive, this hybrid obtains a saving of the consumption of approximately 20 %. By means of the design of the components and by means of the selection of a standard installation size, all hybrid-specific construction units in the vehicle porch could be arranged. Here, a special role comes to the used battery technology, since it became possible to arrange the hybrid battery in the size and the building area of a conventional starter battery accordingly.

  10. Potential Climate and Ozone Impacts From Hybrid Rocket Engine Emissions

    Science.gov (United States)

    Ross, M.

    2009-12-01

    Hybrid rocket engines that use N2O as an oxidizer and a solid hydrocarbon (such as rubber) as a fuel are relatively new. Little is known about the composition of such hybrid engine emissions. General principles and visual inspection of hybrid plumes suggest significant soot and possibly NO emissions. Understanding hybrid rocket emissions is important because of the possibility that a fleet of hybrid powered suborbital rockets will be flying on the order of 1000 flights per year by 2020. The annual stratospheric emission for these rockets would be about 10 kilotons, equal to present day solid rocket motor (SRM) emissions. We present a preliminary analysis of the magnitude of (1) the radiative forcing from soot emissions and (2) the ozone depletion from soot and NO emissions associated with such a fleet of suborbital hybrid rockets. Because the details of the composition of hybrid emissions are unknown, it is not clear if the ozone depletion caused by these hybrid rockets would be more or less than the ozone depletion from SRMs. We also consider the climate implications associated with the N2O production and use requirements for hybrid rockets. Finally, we identify the most important data collection and modeling needs that are required to reliably assess the complete range of environmental impacts of a fleet of hybrid rockets.

  11. Applying hybridity: rhythms of the Hajj, Tumblr, and Snowden.

    Directory of Open Access Journals (Sweden)

    Paul O'Connor

    2013-12-01

    Full Text Available Hybridity has long been a contested term, critiqued as elitist and contradictory. This paper begins by arguing that hybridity has been debated too often and applied too seldom. It takes the premise that hybridity is an everyday fact of life and accordingly it should be articulated in academic works as a mode of analysis. In acknowledging works that call for the utilization of hybridity’s analytical potential this work applies hybridity to the analysis of three disparate topics, the modern pilgrimage to Mecca or hajj, the social networking and blogging platform Tumblr, and the Edward Snowden affair. Hybridity is contrasted with Lefebvre’s rhythmanalysis and applied as a conjoined conceptual focus on these issues. In each scenario a variety of hybrid connections are presented and situated in Bauman’s liquid modernity. These representations of hybridity highlight the manifold dimensions of the concept itself, that it can be superficial, political, celebrated, progressive, and mundane. Rather than dismiss the conceptual complexities of hybridity this paper calls for a harnessing of the broad scope of inference that hybridity presents in application. Working with hybridity thus provides a way to link topics and work organically between multiple disciplines.

  12. Optimization of Renewable Energy Hybrid System for Grid Connected Application

    Directory of Open Access Journals (Sweden)

    Mustaqimah Mustaqimah

    2012-10-01

    Full Text Available ABSTRACT. Hybrid energy systems are pollution free, takes low cost and less gestation period, user and social friendly. Such systems are important sources of energy for shops, schools, and clinics in village communities especially in remote areas. Hybrid systems can provide electricity at a comparatively economic price in many remote areas. This paper presents a method to jointly determine the sizing and operation control of hybrid energy systems. The model, PV wind hydro and biomass hybrid system connects to grid. The system configuration of the hybrid is derived based on a theoretical domestic load at a typical location and local solar radiation, wind and water flow rate data and biomass availability. The hybrid energy system is proposed for 10 of teacher’s houses of Industrial Training Institute, Mersing. It is predicted 10 kW load consumption per house. The hybrid energy system consists of wind, solar, biomass, hydro, and grid power. Approximately energy consumption is 860 kWh/day with a 105 kW peak demand load. The proposed hybrid renewable consists of solar photovoltaic (PV panels, wind turbine, hydro turbine and biomass. Battery and inverter are included as part of back-up and storage system. It provides the economic sensitivity of hybridization and the economic and environmental benefits of using a blend of technologies. It also presents the trade off that is involved in optimizing a hybrid energy system to harness and utilize the available renewable energy resources efficiently.

  13. Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives.

    Science.gov (United States)

    De Munck, Jan; Mine, Atsushi; Van den Steen, Philippe E; Van Landuyt, Kirsten L; Poitevin, André; Opdenakker, Ghislain; Van Meerbeek, Bart

    2010-10-01

    Endogenous matrix metalloproteinases (MMPs) released by adhesive procedures may degrade collagen in the hybrid layer and so compromise the bonding effectiveness of etch-and-rinse adhesives. In this study, endogenous enzymatic degradation was evaluated for several simplified self-etch adhesives. In addition, primers were modified by adding two MMP inhibitors: chlorhexidine, a commonly used disinfectant, but also a non-specific MMP inhibitor; and SB-3CT, a specific inhibitor of MMP-2 and MMP-9. Gelatin zymography of fresh human dentin powder was used to identify the enzymes released by the adhesives. Micro-tensile bond strength (μTBS) testing was used to assess the mechanical properties of resin-dentin interfaces over time. In none of the experimental groups treated with the mild self-etch adhesives was MMP-2 and/or MMP-9 identified. Also, no difference in the μTBS was measured for the inhibitor-modified and the control inhibitor-free adhesives after 6 months of water storage. It is concluded that in contrast to etch-and-rinse adhesives, the involvement of endogenous MMP-2 and MMP-9 in the bond-degradation process is minimal for mild self-etch adhesives.

  14. Dehydrocoupling and Silazane Cleavage Routes to Organic-Inorganic Hybrid Polymers with NBN Units in the Main Chain.

    Science.gov (United States)

    Lorenz, Thomas; Lik, Artur; Plamper, Felix A; Helten, Holger

    2016-06-13

    Despite the great potential of both π-conjugated organoboron polymers and BN-doped polycyclic aromatic hydrocarbons in organic optoelectronics, our knowledge of conjugated polymers with B-N bonds in their main chain is currently scarce. Herein, the first examples of a new class of organic-inorganic hybrid polymers are presented, which consist of alternating NBN and para-phenylene units. Polycondensation with B-N bond formation provides facile access to soluble materials under mild conditions. The photophysical data for the polymer and molecular model systems of different chain lengths reveal a low extent of π-conjugation across the NBN units, which is supported by DFT calculations. The applicability of the new polymers as macromolecular polyligands is demonstrated by a cross-linking reaction with Zr(IV) .

  15. Three- to five-year results with the cementless Harris-Galante acetabular component used in hybrid total hip arthroplasty.

    Science.gov (United States)

    Kienapfel, H; Pitzer, W; Griss, P

    1992-01-01

    In this paper we present our 3- to 5-year results after hybrid total hip replacement using the cementless porous coated Harris-Galante acetabular component and the cemented Griss femoral component in 39 patients with 40 implantations. Postoperatively, mild to moderate pain was experienced by 16.1% of patients, mostly following hard activity. A slight to moderate limp occurred in 24.2%. All patients were able to walk more than 1000 m. Full-time use of support was required by 2.8%. The postoperative range of motion was increased in 93.9%. Radiographically, none of the acetabular or femoral components had to be classified as unstable. Only one acetabular component displayed complete (i.e., along all interface zones) radiolucency and was therefore classified as possibly unstable.

  16. Hybrid Model of Content Extraction

    DEFF Research Database (Denmark)

    Qureshi, Pir Abdul Rasool; Memon, Nasrullah

    2012-01-01

    We present a hybrid model for content extraction from HTML documents. The model operates on Document Object Model (DOM) tree of the corresponding HTML document. It evaluates each tree node and associated statistical features like link density and text distribution across the node to predict...... model outperformed other existing content extraction models. We present a browser based implementation of the proposed model as proof of concept and compare the implementation strategy with various state of art implementations. We also discuss various applications of the proposed model with special...

  17. Uncommon presentation of pulmonary aspergilloma

    Directory of Open Access Journals (Sweden)

    Baradkar V

    2009-01-01

    Full Text Available Cases of pulmonary aspergilloma without any predisposing factors are rarely reported. Clinical presentation varies from case to case. Here, we report a case of pulmonary aspergilloma in a 60-year-old male patient who was admitted to the Intensive Respiratory Care Unit with spontaneous pneumothorax. The patient had a history of dyspnea on exertion since 9 months and mild haemoptysis since the last 6 months. A computerised tomographic scan of the lungs showed a lesion in the left main bronchus along with obstructive emphysema of the right lung, moderate pneumothorax and mediastinal emphysema. Bronchoscopy was performed and the biopsy samples were processed for histopathological examination and culture on Sabouraud′s dextrose agar, which yielded growth of Aspergillus flavus. Repeat sputum samples also yielded the growth of A. flavus . The patient responded to intravenous liposomaamphotericin B and intercostal drainage.

  18. Hybrid electric vehicles TOPTEC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-21

    This one-day TOPTEC session began with an overview of hybrid electric vehicle technology. Updates were given on alternative types of energy storage, APU control for low emissions, simulation programs, and industry and government activities. The keynote speech was about battery technology, a key element to the success of hybrids. The TOPEC concluded with a panel discussion on the mission of hybrid electric vehicles, with a perspective from industry and government experts from United States and Canada on their view of the role of this technology.

  19. Hybrid systems with constraints

    CERN Document Server

    Daafouz, Jamal; Sigalotti, Mario

    2013-01-01

    Control theory is the main subject of this title, in particular analysis and control design for hybrid dynamic systems.The notion of hybrid systems offers a strong theoretical and unified framework to cope with the modeling, analysis and control design of systems where both continuous and discrete dynamics interact. The theory of hybrid systems has been the subject of intensive research over the last decade and a large number of diverse and challenging problems have been investigated. Nevertheless, many important mathematical problems remain open.This book is dedicated mainly to

  20. Hybrid Bloch Brane

    CERN Document Server

    Bazeia, D; Losano, L

    2016-01-01

    This work reports on models described by two real scalar fields coupled with gravity in the five-dimensional spacetime, with a warped geometry involving one infinite extra dimension. Through a mechanism that smoothly changes a thick brane into a hybrid brane, one investigates the appearance of hybrid branes hosting internal structure, characterized by the splitting on the energy density and the volcano potential, induced by the parameter which controls interactions between the two scalar fields. In particular, we investigate distinct symmetric and asymmetric hybrid brane scenarios.

  1. Hybrid Bloch brane

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D.; Lima, Elisama E.M.; Losano, L. [Universidade Federal da Paraiba, Departamento de Fisica, Joao Pessoa, PB (Brazil)

    2017-02-15

    This work reports on models described by two real scalar fields coupled with gravity in the five-dimensional spacetime, with a warped geometry involving one infinite extra dimension. Through a mechanism that smoothly changes a thick brane into a hybrid brane, one investigates the appearance of hybrid branes hosting internal structure, characterized by the splitting on the energy density and the volcano potential, induced by the parameter which controls interactions between the two scalar fields. In particular, we investigate distinct symmetric and asymmetric hybrid brane scenarios. (orig.)

  2. Hybrid silicon evanescent devices

    Directory of Open Access Journals (Sweden)

    Alexander W. Fang

    2007-07-01

    Full Text Available Si photonics as an integration platform has recently been a focus of optoelectronics research because of the promise of low-cost manufacturing based on the ubiquitous electronics fabrication infrastructure. The key challenge for Si photonic systems is the realization of compact, electrically driven optical gain elements. We review our recent developments in hybrid Si evanescent devices. We have demonstrated electrically pumped lasers, amplifiers, and photodetectors that can provide a low-cost, scalable solution for hybrid integration on a Si platform by using a novel hybrid waveguide architecture, consisting of III-V quantum wells bonded to Si waveguides.

  3. Corrosion Inhibition of Mild Steel in Seawater using Jatropha Stem

    Directory of Open Access Journals (Sweden)

    Olawale Olamide

    2016-10-01

    Full Text Available The present work investigate the inhibition of Jatropha Stem Extract (JSE in sea water using mild steel coupons of dimension 5 × 5 × 0.5 cm. The cupons were immersed in test solutions of sea water and varied concentrations of extracts of 0.1g/l to 0.9g/l was used. The functional groups of the compounds was analyzed using an FTIR. The results showed that as the concentration of the extract increases, there was a reduction in the corrosion rates. Furthermore, as the extract concentrations increased from 0.1g/l to 0.4g/l at 48hrs exposure time, the weight loss decreased by 14.3% in the medium. However, the Jatropha Stem Extract was absorbed on the substrate surface to inhibit corrosion, the morphology of phases formed from the scanning Electron Microscopy examination confirmed this trend. Hence, JSE is a good and safe inhibitor in sea water solution. The FT-IR results also indicates the presence of active corrosion inhibitor present in the Jatropha Stem.

  4. Extended Elliptic Mild Slope Equation Incorporating the Nonlinear Shoaling Effect

    Directory of Open Access Journals (Sweden)

    Xiao Qian-lu

    2016-10-01

    Full Text Available The transformation during wave propagation is significantly important for the calculations of hydraulic and coastal engineering, as well as the sediment transport. The exact wave height deformation calculation on the coasts is essential to near-shore hydrodynamics research and the structure design of coastal engineering. According to the wave shoaling results gained from the elliptical cosine wave theory, the nonlinear wave dispersion relation is adopted to develop the expression of the corresponding nonlinear wave shoaling coefficient. Based on the extended elliptic mild slope equation, an efficient wave numerical model is presented in this paper for predicting wave deformation across the complex topography and the surf zone, incorporating the nonlinear wave dispersion relation, the nonlinear wave shoaling coefficient and other energy dissipation factors. Especially, the phenomenon of wave recovery and second breaking could be shown by the present model. The classical Berkhoff single elliptic topography wave tests, the sinusoidal varying topography experiment, and complex composite slopes wave flume experiments are applied to verify the accuracy of the calculation of wave heights. Compared with experimental data, good agreements are found upon single elliptical topography and one-dimensional beach profiles, including uniform slope and step-type profiles. The results indicate that the newly-developed nonlinear wave shoaling coefficient improves the calculated accuracy of wave transformation in the surf zone efficiently, and the wave breaking is the key factor affecting the wave characteristics and need to be considered in the nearshore wave simulations.

  5. SELF-CONTROL FORMATION TECHNOLOGY FOR PRIMARY SCHOOL CHILDREN WITH MILD MENTAL RETARDATION IN LEARNING PROCESS

    Directory of Open Access Journals (Sweden)

    Vera A. Galkina

    2015-01-01

    Full Text Available The purpose of the article is to present self-control development technology meeting up-to-date requirements in the special education for pupils with mild mental retardation; to reveal the self-control special features for children of the studied category found during the experiment; to show necessity of the task-oriented work. Methods. The methods involve theoretical analysis of relevant psychologicpedagogical and methodical literature; empiric methods (conversation, writing tasks, observation; pedagogic experiment; quantitative and qualitative analysis. Results. The article contains the data obtained during the experiment concerning study of the self-control special features for primary school children with mild mental retardation in learning process. The author describes and scientifically justifies the self-control development technology based on the step-bystep approach for children of the studied category. The revealed reasons of low self-control level for primary school children with intellectual disorder are proven by qualitative and quantitative analysis. The presented experimental results confirm the developed technology efficiency and can be applied while studying of all disciplines at primary school. Scientific novelty. For the first time the unified (may be used at all subjects and comprehensive (for all self-control components self-control development technology was developed and proven for primary school children with mild mental disorder in learning process; transient phase necessity is proved and justified for mastering all control kinds by primary school children with mild mental retardation. Practical significance. The developed technology allows qualitative enhancement of learning activities for primary school children with mild mental retardation. The research results may be used in both correctional and educational work at special (correctional schools (type VIII and at general-education schools. In addition the results

  6. Fusión peruana : contemporary Peruvian musical hybrids

    OpenAIRE

    Dodge, Kimberly A.

    2008-01-01

    This thesis discusses popular Peruvian musical hybrids. It presents an overview of the major conceptual tools used to evaluate cultural mixing, including hybridization, transculturation, and mestizaje, and important theories in Latin American musical and cultural analysis, particularly with regards to national identity. Next, it identifies and analyzes Peruvian musical history within the past century, focusing on the hybridization of national genres with international forms. It describes the ...

  7. Hybrid machining processes perspectives on machining and finishing

    CERN Document Server

    Gupta, Kapil; Laubscher, R F

    2016-01-01

    This book describes various hybrid machining and finishing processes. It gives a critical review of the past work based on them as well as the current trends and research directions. For each hybrid machining process presented, the authors list the method of material removal, machining system, process variables and applications. This book provides a deep understanding of the need, application and mechanism of hybrid machining processes.

  8. Hybrid Models of Alternative Current Filter for Hvdc

    Directory of Open Access Journals (Sweden)

    Ufa Ruslan A.

    2017-01-01

    Full Text Available Based on a hybrid simulation concept of HVDC, the developed hybrid AC filter models, providing the sufficiently full and adequate modeling of all single continuous spectrum of quasi-steady-state and transient processes in the filter, are presented. The obtained results suggest that usage of the hybrid simulation approach is carried out a methodically accurate with guaranteed instrumental error solution of differential equation systems of mathematical models of HVDC.

  9. Chaotic mixer improves microarray hybridization.

    Science.gov (United States)

    McQuain, Mark K; Seale, Kevin; Peek, Joel; Fisher, Timothy S; Levy, Shawn; Stremler, Mark A; Haselton, Frederick R

    2004-02-15

    Hybridization is an important aspect of microarray experimental design which influences array signal levels and the repeatability of data within an array and across different arrays. Current methods typically require 24h and use target inefficiently. In these studies, we compare hybridization signals obtained in conventional static hybridization, which depends on diffusional target delivery, with signals obtained in a dynamic hybridization chamber, which employs a fluid mixer based on chaotic advection theory to deliver targets across a conventional glass slide array. Microarrays were printed with a pattern of 102 identical probe spots containing a 65-mer oligonucleotide capture probe. Hybridization of a 725-bp fluorescently labeled target was used to measure average target hybridization levels, local signal-to-noise ratios, and array hybridization uniformity. Dynamic hybridization for 1h with 1 or 10ng of target DNA increased hybridization signal intensities approximately threefold over a 24-h static hybridization. Similarly, a 10- or 60-min dynamic hybridization of 10ng of target DNA increased hybridization signal intensities fourfold over a 24h static hybridization. In time course studies, static hybridization reached a maximum within 8 to 12h using either 1 or 10ng of target. In time course studies using the dynamic hybridization chamber, hybridization using 1ng of target increased to a maximum at 4h and that using 10ng of target did not vary over the time points tested. In comparison to static hybridization, dynamic hybridization reduced the signal-to-noise ratios threefold and reduced spot-to-spot variation twofold. Therefore, we conclude that dynamic hybridization based on a chaotic mixer design improves both the speed of hybridization and the maximum level of hybridization while increasing signal-to-noise ratios and reducing spot-to-spot variation.

  10. Electroactive functional hybrid layered nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Destri, Giovanni Li; Torrisi, Vanna; Marletta, Giovanni [Laboratory for Molecular Surfaces and Nanotechnology (LAMSUN) - University of Catania and CSGI - Catania (Italy)

    2012-07-11

    Two methodologies to build new nanostructured hybrid layered nanocomposites are presented. The first one involves the preparation of hybrid metal/polymer nanolayers (NLs) by combining two monolayer preparation techniques: Horizontal Precipitation Langmuir Blodgett method (HP-ML), for copolymer monolayers and sputter deposition technique, for Au NLs deposition. The second methodology is aimed to prepare regular arrays of nanopores, with diameter ranging between 40-100 nm, in ultra-thin films of electroactive polymers, to obtain embedded regular arrays of nanopores filled by a further electroactive organic component. The produced hybrid MLs have been characterized by means of X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM) and Grazing Incidence X-ray Diffraction (GI-XRD). In the first case, current-voltage (I-V) measurements demonstrate that the multilayers exhibit a bipolar conduction behaviour (electrons and holes carriers), with a peculiar transition in the nature of the majority carriers (from holes to electrons) above a threshold number of bilayers. In the second case, it is found that the degree of pore filling, as well as the polymer crystallinity can be easily modulated, prompting the tuning of the photoresponse of the nanocomposites.

  11. Hybrid cluster identification

    Science.gov (United States)

    Martín-Herrero, J.

    2004-10-01

    I present a hybrid method for the labelling of clusters in two-dimensional lattices, which combines the recursive approach with iterative scanning to reduce the stack size required by the pure recursive technique, while keeping its benefits: single pass and straightforward cluster characterization and percolation detection parallel to the labelling. While the capacity to hold the entire lattice in memory is usually regarded as the major constraint for the applicability of the recursive technique, the required stack size is the real limiting factor. Resorting to recursion only for the transverse direction greatly reduces the recursion depth and therefore the required stack. It also enhances the overall performance of the recursive technique, as is shown by results on a set of uniform random binary lattices and on a set of samples of the Ising model. I also show how this technique may replace the recursive technique in Wolff's cluster algorithm, decreasing the risk of stack overflow and increasing its speed, and the Hoshen-Kopelman algorithm in the Swendsen-Wang cluster algorithm, allowing effortless characterization during generation of the samples and increasing its speed.

  12. Hybrid superconductor magnet bearings

    Science.gov (United States)

    Chu, Wei-Kan

    1995-01-01

    Hybrid superconductor magnet bearings (HSMB's) utilize high temperature superconductors (HTS's) together with permanent magnets to form a frictionless interface between relatively rotating parts. They are low mass, stable, and do not incur expenditure of energy during normal operation. There is no direct physical contact between rotor and stator, and hence there is no wear and tear. However, just as any other applications of HTS's, it requires a very cold temperature to function. Whereas this might be perceived as a disadvantage on earth, it is of no great concern in space or on the moon. To astronomers, the moon is an excellent site for an observatory, but the cold and dusty vacuum environment on the moon precludes the use of mechanical bearings on the telescope mounts. Furthermore, drive mechanisms with very fine steps, and hence bearings with extremely low friction are needed to track a star from the moon, because the moon rotates very slowly. All aspects considered, the HSMB is about the only candidate that fits in naturally. Here, we present a design for one such bearing, capable of supporting a telescope that weighs about 3 lbs on Earth.

  13. Hybrid manifold embedding.

    Science.gov (United States)

    Liu, Yang; Liu, Yan; Chan, Keith C C; Hua, Kien A

    2014-12-01

    In this brief, we present a novel supervised manifold learning framework dubbed hybrid manifold embedding (HyME). Unlike most of the existing supervised manifold learning algorithms that give linear explicit mapping functions, the HyME aims to provide a more general nonlinear explicit mapping function by performing a two-layer learning procedure. In the first layer, a new clustering strategy called geodesic clustering is proposed to divide the original data set into several subsets with minimum nonlinearity. In the second layer, a supervised dimensionality reduction scheme called locally conjugate discriminant projection is performed on each subset for maximizing the discriminant information and minimizing the dimension redundancy simultaneously in the reduced low-dimensional space. By integrating these two layers in a unified mapping function, a supervised manifold embedding framework is established to describe both global and local manifold structure as well as to preserve the discriminative ability in the learned subspace. Experiments on various data sets validate the effectiveness of the proposed method.

  14. Hybrid polymer microspheres

    Science.gov (United States)

    Rembaum, A.

    1980-01-01

    Techniques have been successfully tested for bonding polymeric spheres, typically 0.1 micron in diameter, to spheres with diameter up to 100 microns. Hybrids are being developed as improved packing material for ion-exchange columns, filters, and separators.

  15. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T. (Inventor); Sahimi, Muhammad (Inventor); Fayyaz-Najafi, Babak (Inventor); Harale, Aadesh (Inventor); Park, Byoung-Gi (Inventor); Liu, Paul K. T. (Inventor)

    2011-01-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  16. Functional hybrid materials

    National Research Council Canada - National Science Library

    Fahmi, Amir; Pietsch, Torsten; Mendoza, Cesar; Cheval, Nicolas

    2009-01-01

    .... This paper describes our group's achievements towards the development of multifunctional nanostructures via self-assembly of hybrid systems based on the block copolymer PS-b-P4VP and inorganic nanoparticles (NPs...

  17. Hybrid Rocket Technology

    Directory of Open Access Journals (Sweden)

    Sankaran Venugopal

    2011-04-01

    Full Text Available With their unique operational characteristics, hybrid rockets can potentially provide safer, lower-cost avenues for spacecraft and missiles than the current solid propellant and liquid propellant systems. Classical hybrids can be throttled for thrust tailoring, perform in-flight motor shutdown and restart. In classical hybrids, the fuel is stored in the form of a solid grain, requiring only half the feed system hardware of liquid bipropellant engines. The commonly used fuels are benign, nontoxic, and not hazardous to store and transport. Solid fuel grains are not highly susceptible to cracks, imperfections, and environmental temperature and are therefore safer to manufacture, store, transport, and use for launch. The status of development based on the experience of the last few decades indicating the maturity of the hybrid rocket technology is given in brief.Defence Science Journal, 2011, 61(3, pp.193-200, DOI:http://dx.doi.org/10.14429/dsj.61.518

  18. Nitrous Paraffin Hybrid Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Nitrous Oxide Paraffin Hybrid engine (N2OP) is a proposed technology designed to provide small launch vehicles with high specific impulse, indefinitely storable...

  19. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T.; Sahimi, Muhammad; Fayyaz-Najafi, Babak; Harale, Aadesh; Park, Byoung-Gi; Liu, Paul K. T.

    2011-03-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  20. ANALYS OF EXPERIMENTAL HYBRID CAR TESTING RESULTS ON URBAN DRIVING CYCLE

    Directory of Open Access Journals (Sweden)

    S. Serikov

    2014-02-01

    Full Text Available The experimental hybrid car testing results are presented. The estimation of hybrid car draft-speed characteristics, energy and ecological indicators on urban driving cycle are given.

  1. Simulation of hybrid solar power plants

    Science.gov (United States)

    Dieckmann, Simon; Dersch, Jürgen

    2017-06-01

    Hybrid solar power plants have the potential to combine advantages of two different technologies at the cost of increased complexity. The present paper shows the potential of the software greenius for the techno-economic evaluation of hybrid solar power plants and discusses two exemplary scenarios. Depreciated Concentrated Solar Power (CSP) plants based on trough technology can be retrofitted with solar towers in order to reach higher steam cycle temperatures and hence efficiencies. Compared to a newly built tower plant the hybridization of a depreciated trough plant causes about 30% lower LCOE reaching 104 /MWh. The second hybrid scenario combines cost-efficient photovoltaics with dispatchable CSP technology. This hybrid plant offers very high capacity factors up to 69% based on 100% load from 8am to 11pm. The LCOE of the hybrid plant are only slightly lower (174 vs. 186 /MWh) compared to the pure CSP plant because the capital expenditure for thermal storage and power block remains the same while the electricity output is much lower.

  2. Hybridity in Disgrace

    Institute of Scientific and Technical Information of China (English)

    刘建平

    2015-01-01

    John Maxwell Coetzee's masterpiece-Disgrace is the representative work about post colonialism.The novel describes a series of disgraceful events happened between the white and the black in the post apartheid South Africa.The famous literature theory-hybridity of Homi K.Bhabha is the very key theory to analyze the work.In post apartheid South Africa,hybridity is the only way for the white and the black to coexist.

  3. Hybrid Baryon Signatures

    CERN Document Server

    Page, P R

    2000-01-01

    We discuss whether a low-lying hybrid baryon should be defined as a three quark - gluon bound state or as three quarks moving on an excited adiabatic potential. We show that the latter definition becomes exact, not only for very heavy quarks, but also for specific dynamics. We review the literature on the signatures of hybrid baryons, with specific reference to strong hadronic decays, electromagnetic couplings, diffractive production and production in psi decay.

  4. Hybrid vertical cavity laser

    DEFF Research Database (Denmark)

    Chung, Il-Sug; Mørk, Jesper

    2010-01-01

    A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide.......A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide....

  5. Requirements for Hybrid Cosimulation

    Science.gov (United States)

    2014-08-16

    hybrid cosimulation version of the Functional Mockup Interface (FMI) standard. A cosimulation standard de nes interfaces that enable diverse simulation...cosimulation standards, and specifically provides guidance for development of a hybrid cosimulation version of the Functional Mockup Interface (FMI) standard...V. Peetz, and S. Wolf. The functional mockup interface for tool independent exchange of simulation models. In Proc. of the 8-th International

  6. Biological characteristics of tomato mild mottle potyvirus isolated ...

    African Journals Online (AJOL)

    Biological characteristics of tomato mild mottle potyvirus isolated from tomato and thorn ... (Datura stramonium) and tomato (Lycopersicon lycopersicum (L.) Karst. ... Solanum demissum L., while the PVY isolate infected Chenopodium quinoa ...

  7. INHIBITION OF THE CORROSION OF MILD STEEL IN ...

    African Journals Online (AJOL)

    explained in terms of the difference in their molecular structures and solubility rather than .... Kinetic and thermodynamic data for the corrosion of mild steel in 0.1 M HCl solution containing ... transition state theory for ING and IN, respectively.

  8. Skip the Antibiotics for Mild Eczema in Kids

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_164083.html Skip the Antibiotics for Mild Eczema in Kids Skin condition cleared ... March 14, 2017 (HealthDay News) -- Despite widespread use, antibiotics are not an effective treatment for milder cases ...

  9. Timing of cholecystectomy after mild biliary pancreatitis: a systematic review.

    NARCIS (Netherlands)

    Baal, M.C.P.M. van; Besselink, M.G.; Bakker, O.J.; Santvoort, H.C. van; Schaapherder, A.F.; Nieuwenhuijs, V.B.; Gooszen, H.G.; Ramshorst, B. van; Boerma, D.

    2012-01-01

    OBJECTIVES: To determine the risk of recurrent biliary events in the period after mild biliary pancreatitis but before interval cholecystectomy and to determine the safety of cholecystectomy during the index admission. BACKGROUND: Although current guidelines recommend performing cholecystectomy earl

  10. Inferential reading abilities of mildly mentally retarded and nonretarded students.

    Science.gov (United States)

    Bos, C S; Tierney, R J

    1984-07-01

    The inferential operations of mildly mentally retarded students reading at the intermediate level were investigated using methods based on discourse comprehension theory. We hypothesized that problems encountered in reading by these students are related to difficulties in generating logical inferences. Mildly retarded junior-high students and nonretarded third-grade students of the same reading comprehension level read and recalled a descriptive expository and a narrative passage. On the expository passage mildly retarded students generated the same quantity of inferences as did nonretarded students, but the inferences were qualitatively inferior. On the narrative passage the differences between the two groups were not significant. These findings were discussed in relation to the cognitive functioning of mildly retarded students.

  11. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms.

    NARCIS (Netherlands)

    Zannad, Faiez; McMurray, John J. V.; Krum, Henry; van Veldhuisen, Dirk J.; Swedberg, Karl; Shi, Harry; Vincent, John; Pocock, Stuart J.; Pitt, Bertram

    2011-01-01

    Background: Mineralocorticoid antagonists improve survival among patients with chronic, severe systolic heart failure and heart failure after myocardial infarction. We evaluated the effects of eplerenone in patients with chronic systolic heart failure and mild symptoms. Methods: In this randomized,

  12. Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

    OpenAIRE

    Suo, Lin; Zhao, Liyan; Si, Jijian; Liu, Jianfeng; Zhu, Weili; Chai, Baisheng; Zhang, Yan; Feng, Jiajia; Ding, Zengbo; Luo, Yixiao; Shi, Haishui; Shi, Jie; Lu, Lin

    2013-01-01

    Stress in adolescence has been widely demonstrated to have a lasting impact in humans and animal models. Developmental risk and protective factors play an important role in the responses to stress in adulthood. Mild-to-moderate stress in adolescence may resist the negative impacts of adverse events in adulthood. However, little research on resilience has been conducted. In this study, we used a predictable chronic mild stress (PCMS) procedure (5 min of daily restraint stress for 28 days) in a...

  13. PSYCHOSENSORIMOTOR DEVELOPMENT OF PRESCHOOLERS WITH MILD CASE OF PSEUDOBULBAR DYSARTHRIA

    OpenAIRE

    2012-01-01

    The article covers the research of connection between mental, sensor and motor development, sensorimotor, ideomotor and emotional-motor reactions and also their variations by preschoolers with mild case of pseudobulbar dysarthria. The aim of the research is in theoretical study of specification of psychosensorimotor development of preschoolers with mild case of pseudobulbar dysarthria. Novelty of the research is in substantiation of the theoretical importance of studying psychosensorimotor de...

  14. Disruption of mitochondrial function in interpopulation hybrids of Tigriopus californicus.

    Science.gov (United States)

    Ellison, Christopher K; Burton, Ronald S

    2006-07-01

    Electron transport system (ETS) function in mitochondria is essential for the aerobic production of energy. Because ETS function requires extensive interactions between mitochondrial and nuclear gene products, coadaptation between mitochondrial and nuclear genomes may evolve within populations. Hybridization between allopatric populations may then expose functional incompatibilities between genomes that have not coevolved. The intertidal copepod Tigriopus californicus has high levels of nucleotide divergence among populations at mitochondrial loci and suffers F2 hybrid breakdown in interpopulation hybrids. We hypothesize that hybridization results in incompatibilities among subunits in ETS enzyme complexes and that these incompatibilities result in diminished mitochondrial function and fitness. To test this hypothesis, we measured fitness, mitochondrial function, and ETS enzyme activity in inbred recombinant hybrid lines of Tigriopus californicus. We found that (1) both fitness and mitochondrial function are reduced in hybrid lines, (2) only those ETS enzymes with both nuclear and mitochondrial subunits show a loss of activity in hybrid lines, and (3) positive relationships exist between ETS enzyme activity and mitochondrial function and between mitochondrial function and fitness. We also present evidence that hybrid lines harboring mitochondrial DNA (mtDNA) and mitochondrial RNA polymerase (mtRPOL) from the same parental source population have higher fitness than those with mtDNA and mtRPOL from different populations, suggesting that mitochondrial gene regulation may play a role in disruption of mitochondrial performance and fitness of hybrids. These results suggest that disruption of coadaptation between nuclear and mitochondrial genes contributes to the phenomenon of hybrid breakdown.

  15. Hybrid rice achievements, development and prospect in China

    Institute of Scientific and Technical Information of China (English)

    MA Guo-hui; YUAN Long-ping

    2015-01-01

    This article reviews the history and progress of hybrid rice development. Hybrid rice research was initiated back in 1964, and commercialized in 1976. Three-line and two-line system hybrid rice were developed in 1974 and 1995, respectively. Research on super hybrid rice, which was ifrst launched by Ministry of Agriculture, China in 1996, is discussed, and the great progress of super hybrid rice had been achieved with a new yield record by 15.4 t ha–1 in the 6.84 ha demonstration location in Xupu, Hunan Province, China in 2014. And the mechanism of heterosis, the techniques of hybrid seed production and the modern ifeld managements in hybrid rice over the past decades are also discussed. Additional y, this article dealt with the intel ectual property protection (IPR) and development of hybrid rice seed industry in China. Major factors that constrain hybrid rice development are analyzed and possible solutions to this problems are proposed. Final y, the authors present methods to further increase production yield, and propose an improvement for breeding super high-yielding hybrid rice based on these methods.

  16. Development of Zn50 Brazing Alloy for Joining Mild Steel to Mild Steel (SAE1018

    Directory of Open Access Journals (Sweden)

    S.C. Nwigbo

    2014-09-01

    Full Text Available This work has developed new brazing alloys for joining mild steel to mild steel (SAE1018 at a lower temperature. The alloys blends and error analysis were done by experimental design software (Design Expert 8.0.7.1. Design of experiments was done by Scheffe quadratic mixture method. The liquidus temperatures were predicted by calculation of phase diagrams of the alloying metals. The brazing alloys were produced by gravity technique and melted using silicon carbide graphite crucible. The quality of the brazing alloys was analyzed by optical microscopy (OM, atomic absorption spectroscopy (AAS and fourier transform infrared spectroscopy (FT-IR. Brazed joints were produced by torch method with a commercial flux. Brazing temperatures (liquidus were tracked by a digital infrared/laser pyrometer. Some mechanical properties studied were tensile strength and hardness. Finally, brazed joints produced from the developed brazing alloys were compared to that produced from muntz brass. Six (6 brazing alloys were successfully developed. Zinc and manganese were the main components, to which were added; 3 to 4 %wt silver and 11 to15 %wt modifying element. The microstructure showed a typical eutectic structure with zinc-rich phase distributed uniformly in the matrix with a combination of different sizes of dendrite, rounded blocks of compounds and hypoeutectic structures. AAS results indicated minimal out-gassing of zinc and FT-IR results indicated very low presence of atmospheric gas. The range of brazing temperature for best results was recorded from 690.90 to 735.10 0C. The joints produced from the developed brazing alloys had acceptable strengths with improved stress-strain behaviour compared to muntz brass.

  17. Mild extractability and bioavailability of polycyclic aromatic hydrocarbons in soil

    Energy Technology Data Exchange (ETDEWEB)

    Tang, J.; Alexander, M.

    1999-12-01

    A study was conducted to determine the relationship between bioavailability of unaged and aged polycyclic aromatic hydrocarbons (PAHs) in soil and the amounts detected by mild solvent extraction. More aged than unaged anthracene remained in Lima loam following introduction of earthworms (Eisenia foetida), a mixed culture containing anthracene-degrading microorganisms, or earthworms or wheat after bacterial biodegradation of the compound. Aging decreased the percentage of anthracene recovered by mild extraction with n-butanol from soil following introduction of earthworms, growth of wheat, biodegradation by bacteria, or when maintained sterile. Biodegradation resulted in a marked decrease in the percentage of aged and unaged anthracene recovered from soil by mild extraction with n-butanol or ethyl acetate. Aging of fluoranthene and pyrene decreased the amount removed by mild extraction with n-butanol, ethyl acetate, and propanol. The uptake of aged and unaged anthracene, fluoranthene, and pyrene by earthworms was correlated with the amounts recovered from soil by mild extraction with n-butanol, propanol, and ethyl acetate. The retention of aged and unaged anthracene by wheat and barley was correlated with the amounts recovered from soil by the same procedure. The authors suggest that mild extraction with organic solvents can be used to predict the bioavailability of PAHs in soil.

  18. Development of nano SiO{sub 2} incorporated nano zinc phosphate coatings on mild steel

    Energy Technology Data Exchange (ETDEWEB)

    Tamilselvi, M. [Department of Chemistry, Thiru Kolanjiappar Government Arts College, Virudhachalam 606001 (India); Kamaraj, P. [Department of Chemistry, SRM University, Kattankulathur 603203 (India); Arthanareeswari, M., E-mail: arthanareeswari@gmail.com [Department of Chemistry, SRM University, Kattankulathur 603203 (India); Devikala, S.; Selvi, J. Arockia [Department of Chemistry, SRM University, Kattankulathur 603203 (India)

    2015-03-30

    Highlights: • Nano SiO{sub 2} incorporated nano zinc phosphate coating on mild steel was developed. • Coatings showed enhanced corrosion resistance. • The nano SiO{sub 2} is adsorbed on mild steel surface and become nucleation sites. • The nano SiO{sub 2} accelerates the phosphating process. - Abstract: This paper reports the development of nano SiO{sub 2} incorporated nano zinc phosphate coatings on mild steel at low temperature for achieving better corrosion protection. A new formulation of phosphating bath at low temperature with nano SiO{sub 2} was attempted to explore the possibilities of development of nano zinc phosphate coatings on mild steel with improved corrosion resistance. The coatings developed were studied by Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Electrochemical measurements. Significant variation in the coating weight, morphology and corrosion resistance was observed as nano SiO{sub 2} concentrations varied from 0.5–4 g/L. The results showed that, the nano SiO{sub 2} in the phosphating solution changed the initial potential of the interface between mild steel substrate and phosphating solution and reduce the activation energy of the phosphating process, increase the nucleation sites and yielded zinc phosphate coatings of higher coating weight, greater surface coverage and enhanced corrosion resistance. Better corrosion resistance was observed for coatings derived from phosphating bath containing 1.5 g/L nano SiO{sub 2}. The new formulation reported in the present study was free from Ni or Mn salts and had very low concentration of sodium nitrite (0.4 g/L) as accelerator.

  19. Prospective randomized study of patients with insomnia and mild sleep disordered breathing.

    Science.gov (United States)

    Guilleminault, Christian; Davis, Kala; Huynh, Nelly T

    2008-11-01

    Patients with insomnia may present with mild and often unrecognized obstructive sleep apnea (OSA). To evaluate both subjective and objective outcomes of patients with complaints of insomnia and mild OSA who receive surgical treatment for OSA versus behavioral treatment with cognitive behavioral therapy for insomnia (CBT-I). Prospective study with crossover design of 30 patients with complaints of insomnia and mild OSA. Thirty subjects, matched for age and gender, were randomized with stratification to receive either CBT-I or surgical treatment of OSA as primary treatment. Patients were reassessed after completing the initial intervention and reassigned if agreeable to the alternative treatment option and assessed again on completion of both treatment arms. Outcome measures included clinical impression, Epworth Sleepiness Scale (ESS) score, Fatigue Severity Scale (FSS) score, and polysomnography (PSG) results. Surgery resulted in greater improvements in total sleep time (TST), slow wave sleep and REM sleep duration, respiratory disturbance index, apnea-hypopnea index, minimum oxygen saturation, FSS, and ESS. CBT-I also improved TST and resulted in shorter sleep latency. Surgical intervention for the management of patients with complaints of insomnia and mild OSA demonstrated greater improvement in both subjective and objective outcome measures. Initial treatment of underlying OSA in patients with insomnia was more successful in improving insomnia than CBT-I alone. However CBT-I as initial treatment improved TST compared to baseline; following surgical intervention, it had the additional benefit of further increasing TST and helped to control sleep onset difficulties that may be related to conditioning due to unrecognized symptoms of mild OSA.

  20. Clinical Features for Mild Hand, Foot and Mouth Disease in China.

    Directory of Open Access Journals (Sweden)

    Baoyan Liu

    Full Text Available Mild hand, foot and mouth disease (HFMD is at a critical stage owing to its ease of communicability and a higher risk of developing severe complications and death. Clinical diagnosis of mild HFMD was made by the presenting symptoms and signs (symptoms in brief alone. We aim to evaluate the frequencies of symptoms in a retrospective case series study.We collected epidemiological, demographic, clinical, and laboratory data from outpatient and inpatient settings on the clinical data warehouse system. We principally described the frequencies of symptoms of mild HFMD. Correlations between symptoms with laboratory-confirmed cases were then analyzed.The clinical data warehouse system included 3649 probable cases, between 2010 and 2012, of which 956 (26.20% were laboratory confirmed. The peak incidence was identified in children 2 years of age. A total of 370 of the 956 laboratory confirmed cases (38.70% were associated with enterovirus 71 (EV71. Logistic regression analysis adjusted for geographical variables, age, sex, month of onset, and time from onset to diagnosis showed that the clinical features constipation (P<0.0001; adjusted OR, 95%CI (2.99, 2.28-3.91, and blisters (P<0.0001; adjusted OR, 95%CI (2.16, 1.82-2.56 were positively correlated with the confirmed cases.This is the largest case series study, including all the guideline-mentioned symptoms of mild HFMD. Our findings suggest that blisters and constipation should be considered as potential warning signs while front-line clinicians manage surges of children diagnosed with mild HFMD during a pandemic.

  1. Driving in mild cognitive impairment: The role of depressive symptoms.

    Science.gov (United States)

    Beratis, Ion N; Andronas, Nikos; Kontaxopoulou, Dionysia; Fragkiadaki, Stella; Pavlou, Dimosthenis; Papatriantafyllou, John; Economou, Alexandra; Yannis, George; Papageorgiou, Sokratis G

    2017-07-04

    Previous studies indicate a negative association between depression and driving fitness in the general population. Our goal was to cover a gap in the literature and to explore the link between depressive symptoms and driving behavior in individuals with mild cognitive impairment (MCI) through the use of a driving simulator experiment. Twenty-four individuals with MCI (mean age = 67.42, SD = 7.13) and 23 cognitively healthy individuals (mean age = 65.13, SD = 7.21) were introduced in the study. A valid driving license and regular car use served as main inclusion criteria. Data collection included a neurological/neuropsychological assessment and a driving simulator evaluation. Depressive symptomatology was assessed with the Patient Health Questionnaire (PHQ-9). Significant interaction effects indicating a greater negative impact of depressive symptoms in drivers with MCI than in cognitively healthy drivers were observed in the case of various driving indexes, namely, average speed, accident risk, side bar hits, headway distance, headway distance variation, and lateral position variation. The associations between depressive symptoms and driving behavior remained significant after controlling for daytime sleepiness and cognition. Depressive symptoms could be a factor explaining why certain patients with MCI present altered driving skills. Therefore, interventions for treating the depressive symptoms of individuals with MCI could prove to be beneficial regarding their driving performance.

  2. Borderlines between sarcopenia and mild late-onset muscle disease

    Directory of Open Access Journals (Sweden)

    Johanna ePalmio

    2014-09-01

    Full Text Available Numerous natural or disease-related alterations occur in different tissues of the body with advancing age. Sarcopenia is defined as age-related decrease of muscle mass and strength beginning in mid-adulthood and accelerating in people older than 60 years. Pathophysiology of sarcopenia involves both neural and muscle dependent mechanisms and is enhanced by multiple factors. Aged muscles show loss in fiber number, fiber atrophy and gradual increase in the number of ragged red fibers and cytochrome c oxidase-negative fibers. Generalized loss of muscle tissue and increased amount of intramuscular fat is seen on muscle imaging. However, the degree of these changes vary greatly between individuals and the distinction between normal age-related weakening of muscle strength and clinically significant muscle disease is not always obvious. Because some of the genetic myopathies can present at a very late age and be mild in severity, the correct diagnosis is easily missed. We highlight this difficult borderline zone between sarcopenia and muscle disease by two examples: LGMD1D and myotonic dystrophy type 2. Muscle MRI is a useful tool to help differentiate myopathies from sarcopenia and to reach the correct diagnosis also in the elderly.

  3. Verbal learning strategy following mild traumatic brain injury.

    Science.gov (United States)

    Geary, Elizabeth K; Kraus, Marilyn F; Rubin, Leah H; Pliskin, Neil H; Little, Deborah M

    2011-07-01

    That learning and memory deficits persist many years following mild traumatic brain injury (mTBI) is controversial due to inconsistent objective evidence supporting subjective complaints. Our prior work demonstrated significant reductions in performance on the initial trial of a verbal learning task and overall slower rate of learning in well-motivated mTBI participants relative to demographically matched controls. In our previous work, we speculated that differences in strategy use could explain the differences in rate of learning. The current study serves to test this hypothesis by examining strategy use on the California Verbal Learning Test-Second Edition. Our present findings support the primary hypothesis that mTBI participants under-utilize semantic clustering strategies during list-learning relative to control participants. Despite achieving comparable total learning scores, we posit that the persisting learning and memory difficulties reported by some mTBI patients may be related to reduced usage of efficient internally driven strategies that facilitate learning. Given that strategy training has demonstrated improvements in learning and memory in educational and occupational settings, we offer that these findings have translational value in offering an additional approach in remediation of learning and memory complaints reported by some following mTBI.

  4. Numerical magnitude processing in children with mild intellectual disabilities.

    Science.gov (United States)

    Brankaer, Carmen; Ghesquière, Pol; De Smedt, Bert

    2011-01-01

    The present study investigated numerical magnitude processing in children with mild intellectual disabilities (MID) and examined whether these children have difficulties in the ability to represent numerical magnitudes and/or difficulties in the ability to access numerical magnitudes from formal symbols. We compared the performance of 26 children with MID on a symbolic (digits) and a non-symbolic (dot-arrays) comparison task with the performance of two control groups of typically developing children: one group matched on chronological age and one group matched on mathematical ability level. Findings revealed that children with MID performed more poorly than their typically developing chronological age-matched peers on both the symbolic and non-symbolic comparison tasks, while their performance did not substantially differ from the ability-matched control group. These findings suggest that the development of numerical magnitude representation in children with MID is marked by a delay. This performance pattern was observed for both symbolic and non-symbolic comparison tasks, although difficulties on the former task were more prominent. Interventions in children with MID should therefore foster both the development of magnitude representations and the connections between symbols and the magnitudes they represent.

  5. Cognitive Training in Older Adults with Mild Cognitive Impairment

    Institute of Scientific and Technical Information of China (English)

    LIU Xin Yan; LI Li; XIAO Jia Qing; HE Chang Zhi; LYU Xiu Lin; GAO Lei; YANG Xiao Wei; CUI Xin Gang; FAN Li Hua

    2016-01-01

    ObjectiveWe investigated the feasibility and efficacy of cognitive training for older adults in rural settings and with low education levels, who have mild cognitive impairment (MCI). MethodsForty-five older adults (ages >65 years) with MCI were assigned to treatment or control groups, at a 2:1 ratio. Cognitivetraining occurred in the treatment group for 2 months. The cognitive abilities of the participants were assessed at pre-training, metaphase, and post-training time points, using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), and Hamilton Depression Scale (HAM-D). ResultsFollowing training, cognitive abilities improved in the treatment group, based on the total scores of all 4 measures, as well as specifically on the MoCA and LOTCA. There were differences in the main effects of group and time point on some subscales, but these differences had little, if any, effect on the overall analyses. ConclusionThe present study demonstrated that cognitive training has beneficial effects on attention, language, orientation, visual perception, organization of visual movement, and logical questioning in patients with MCI. Furthermore, the observed effects are long-term changes.

  6. The Early Indicators of Functional Decrease in Mild Cognitive Impairment

    Science.gov (United States)

    Kubicki, Alexandre; Fautrelle, Lilian; Bourrelier, Julien; Rouaud, Olivier; Mourey, France

    2016-01-01

    Objectives: Motor deficiency is associated with cognitive frailty in patients with Mild Cognitive Impairments (MCI). In this study we aimed to test the integrity in muscle synergies involved in an arm-pointing movement in functionally unimpaired MCI patients. We hypothesized that early motor indicators exist in this population at a preclinical level. Methods: Electromyographic signals were collected for 11 muscles in 3 groups: Young Adults (YA), Older Adults (OA), and MCI patients. The OA and MCI groups presented the same functional status. Each subject performed 20 arm-pointing movements from a standing position. Results: The main differences were (1) an earlier activation of the left Obliquus internus in MCI compared with OA group, (2) an earlier activation for the MCI compared with both OA and YA. The temporal differences in muscle synergies between MCI and OA groups were linked with executive functions of MCI patients, assessed by the trail making test. Moreover, the results show a delayed activation of the right Biceps Femoris and the right Erector Spinae at l3 in MCI and OA compared with YA. Interpretation: The motor program changes highlighted in our patient MCI group suggest that discrete modifications of the motor command seem to exist even in the absence of functional impairment. Instead of showing an indication of delayed muscle activation in the MCI patients, our results highlight some early activation of several trunk muscles. PMID:27570509

  7. Efficient Hybrid Method for Binary Floating Point Multiplication

    Directory of Open Access Journals (Sweden)

    S. Praveenkumar Reddy,

    2014-04-01

    Full Text Available This paper presents a high speed binary floating point multiplier based on Hybrid Method. To improve speed multiplication of mantissa is done using Hybrid method replacing existing multipliers like Carry Save Multiplier, Dadda Multiplier and Modified Booth Multiplier. Hybrid method is a combination of Dadda Multiplier and Modified Radix-8 Booth Multiplier. The design achieves high speed with maximum frequency of 555 MHz compared to existing floating point multipliers. The multiplier implemented in Verilog HDL and analyzed in Quartus II 10.0 version. Hybrid Multiplier is compared with existing multipliers.

  8. HOPIS: hybrid omnidirectional and perspective imaging system for mobile robots.

    Science.gov (United States)

    Lin, Huei-Yung; Wang, Min-Liang

    2014-09-04

    In this paper, we present a framework for the hybrid omnidirectional and perspective robot vision system. Based on the hybrid imaging geometry, a generalized stereo approach is developed via the construction of virtual cameras. It is then used to rectify the hybrid image pair using the perspective projection model. The proposed method not only simplifies the computation of epipolar geometry for the hybrid imaging system, but also facilitates the stereo matching between the heterogeneous image formation. Experimental results for both the synthetic data and real scene images have demonstrated the feasibility of our approach.

  9. Regression Rate Study in HTPB/GOX Hybrid Rocket Motors.

    Directory of Open Access Journals (Sweden)

    Philmon George

    1996-12-01

    Full Text Available The theoretical and experimenIal studies on hybrid rocket motor combustion research are briefly reviewed and the need for a clear understanding of hybrid rocket fuel regression rate mechanism is brought out. A test facility established at the Indian Institute of Technology, Madras, for hybrid rocket motor research study is described.The results of an experimental study on hydroxyl terminated polybutadiene and gaseous oxygen hybrid rocket motor are presented. Fuel grains with ammonium perchlorate "additive" have shownenhanced oxidizermass flux dependence. Smallergrains have higher regression rates than those of the larger ones.

  10. High performance hybrid magnetic structure for biotechnology applications

    Science.gov (United States)

    Humphries, David E [El Cerrito, CA; Pollard, Martin J [El Cerrito, CA; Elkin, Christopher J [San Ramon, CA

    2009-02-03

    The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetic or magnetizable molecular structures and targets. Also disclosed are further improvements to aspects of the hybrid magnetic structure, including additional elements and for adapting the use of the hybrid magnetic structure for use in biotechnology and high throughput processes.

  11. Electric and plug-in hybrid vehicles advanced simulation methodologies

    CERN Document Server

    Varga, Bogdan Ovidiu; Moldovanu, Dan; Iclodean, Calin

    2015-01-01

    This book is designed as an interdisciplinary platform for specialists working in electric and plug-in hybrid electric vehicles powertrain design and development, and for scientists who want to get access to information related to electric and hybrid vehicle energy management, efficiency and control. The book presents the methodology of simulation that allows the specialist to evaluate electric and hybrid vehicle powertrain energy flow, efficiency, range and consumption. The mathematics behind each electric and hybrid vehicle component is explained and for each specific vehicle the powertrain

  12. Rice fertility affected by lower temperature in intersubspecific hybrid

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Intersubspecific hybrids of indica-japonica show strong heterosis on yield,and the partial sterility in F1 hybrids can be mitigated by using the wide-compatibility gene, S5n. In the past decade, such hybrids showed normal fertility and high level of heterosis on grain yield, but some of them showed unstable seed-setting rate at low temperature. The present study was conducted to examine the effect of low temperature on fertility of intersubspecific hybrids and to investigate the male gamete abortion at some markers.

  13. Intelligent Control Scheme of Engineering Machinery of Cluster Hybrid System

    Institute of Scientific and Technical Information of China (English)

    GAO Qiang; WANG Hongli

    2005-01-01

    In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the construction environment is complex and there exist many affecting factors. In this paper, hierarchically intelligent control, expert control and fuzzy control are introduced into the discrete subsystems of engineering machinery of cluster hybrid system, so as to rebuild the hybrid system and make the discrete control law easily and effectively obtained. The structures, reasoning mechanism and arithmetic of intelligent control are replanted to discrete dynamic, conti-nuous process and the interface of the hybrid system. The structures of three types of intelligent hybrid system are presented and the human experiences summarized from engineering machinery of cluster are taken into account.

  14. Bimode uninterruptible power supply compatibility in renewable hybrid energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Bower, W. (Sandia National Labs., Albuquerque, NM (USA)); O' Sullivan, G. (Abacus Controls, Inc., Somerville, NJ (USA))

    1990-08-01

    Inverters installed in renewable hybrid energy systems are typically used in a stand-alone mode to supply ac power to loads from battery storage when the engine-generator is not being used. Similarities in topology and in the performance requirements of the standby uninterruptible power supply (UPS) system and the hybrid system suggest the UPS could be used in hybrid energy systems. Another alternative to inverters with add-on charging circuits or standby UPS hardware is the Bimode UPS. The bimode UPS uses common circuitry and power components for dc to ac inversion and battery charging. It also provides an automatic and nearly instantaneous ac power transfer function when the engine-generator is started or stopped. The measured operating and transfer characteristics of a bimode UPS in a utility system and in a hybrid system are presented. The applicability of the bimode UPS to hybrid systems and its compatibility in a PV/engine-generator hybrid system are given.

  15. On statistical properties of Jizba-Arimitsu hybrid entropy

    Science.gov (United States)

    Çankaya, Mehmet Niyazi; Korbel, Jan

    2017-06-01

    Jizba-Arimitsu entropy (also called hybrid entropy) combines axiomatics of Rényi and Tsallis entropy. It has many common properties with them, on the other hand, some aspects as e.g., MaxEnt distributions, are different. In this paper, we discuss statistical properties of hybrid entropy. We define hybrid entropy for continuous distributions and its relation to discrete entropy. Additionally, definition of hybrid divergence and its connection to Fisher metric is also presented. Interestingly, Fisher metric connected to hybrid entropy differs from corresponding Fisher metrics of Rényi and Tsallis entropy. This motivates us to introduce average hybrid entropy, which can be understood as an average between Tsallis and Rényi entropy.

  16. Design and Ballistic Performance of Hybrid Composite Laminates

    Science.gov (United States)

    Ćwik, Tomasz K.; Iannucci, Lorenzo; Curtis, Paul; Pope, Dan

    2016-10-01

    This paper presents an initial design assessment of a series of novel, cost-effective, and hybrid composite materials for applications involving high velocity impacts. The proposed hybrid panels were designed in order to investigate various physical phenomenon occurring during high velocity impact on compliant laminates from a previous study on Dyneema® and Spectra®. In the first, screening phase of the study twenty different hybrid composite laminates were impacted with 20 mm Fragment Simulating Projectiles at 1 km/s striking velocity. The best performing concepts were put forward to phase II with other hybrid concepts involving shear thickening fluids, commonly used in low velocity impacts. The results indicated that it is possible to design hybrid laminates of similar ballistic performance as the reference Dyneema® laminate, but with lower material costs. The optimal hybrid concept involves a fibre reinforced Polypropylene front and a Dyneema® backing.

  17. Atypical presentation of sickle cell disease

    Directory of Open Access Journals (Sweden)

    Md. Abdul Aziz

    2017-02-01

    Full Text Available A 20 year old female presented with a history of frequent syncopal attack since her childhood. Each episode persisted 5-10 min without having any aggravating factor or prodrome. She had persistent generalized bodyache aggravating during the winter. She had jaundice and episodic abdominal pain. She received 1 unit of blood transfusion 4 months back and improved sympto-matically. Patient was mildly anemic, moderately icteric and had mild splenomegaly. Over these long periods of her illness she was thoroughly evaluated several times. Her biochemical and neurological evaluation revealed no abnormalities. But she was treated with anticonvulsant for long time empirically without significant improvement. Her CBC showed microcytic hypochromic anemia. She was negative for Wilson’s disease. Reticulocyte count was high. Coomb’s test was negative. Osmotic fragility test was positive. Hemoglobin electrophoresis revealed Hb-S 60%. Sickling test was found positive. Finally it was diagnosed as a case of HbS/β+.

  18. Sphincter of Oddi Dysfunction: A Perplexing Presentation

    Directory of Open Access Journals (Sweden)

    Sana Ahmad Din

    2016-11-01

    Full Text Available Sphincter of Oddi dysfunction is caused by stenosis or dyskinesia of the sphincter of Oddi, leading to blockage of bile drainage from the common bile duct. We present the case of a 16-year-old female with chronic abdominal pain who underwent laparoscopic cholecystectomy for cholelithiasis but continued to experience abdominal pain, nausea, and vomiting along with persistently elevated ALT and AST levels. Postoperative abdominal ultrasound was nondiagnostic. Esophagogastroduodenoscopy showed mild reflux esophagitis and mild chronic Helicobacter pylori-negative gastritis. Omeprazole was started, but it did not decrease the frequency and severity of the abdominal symptoms. Magnetic resonance cholangiopancreatography did not reveal any pathology. Endoscopic retrograde cholangiopancreatography with manometry confirmed an elevated biliary sphincter pressure. Biliary sphincterotomy was performed, and the symptoms improved.

  19. Mnemonic strategy training partially restores hippocampal activity in patients with mild cognitive impairment

    OpenAIRE

    2012-01-01

    Learning and memory deficits typify patients with mild cognitive impairment (MCI) and are generally attributed to medial temporal lobe dysfunction. Although the hippocampus is perhaps the most commonly studied neuroanatomical structure in these patients, there have been few attempts to identify rehabilitative interventions that facilitate its functioning. Here, we present results from a randomized, controlled, single-blind study in which patients with MCI and healthy elderly controls (HEC) we...

  20. RING CHROMOSOME 13 SYNDROME IN AN ADULT MALE WITH MILD MENTAL RETARDATION

    OpenAIRE

    Matsuishi, Takesi; Millar, Anne; Yamaguchi, Tetsuaki; Endo, Keiko

    1997-01-01

    A case of ring 13 syndrome in an 18-year-old male is presented with particular focus on mental retardation. The clinical picture was characterized by mild mental retardation, microcephaly, large low set ears, a broad nasal bridge, epicanthus, micrognathia and short philtrum. A review of the literature with a focus on mental retardation concluded that descriptions of mental retardation were often unqualified and at times ambiguous. Furthermore, in contrast to the characteristic description of ...

  1. SELF-CONTROL FORMATION TECHNOLOGY FOR PRIMARY SCHOOL CHILDREN WITH MILD MENTAL RETARDATION IN LEARNING PROCESS

    OpenAIRE

    Vera A. Galkina

    2015-01-01

    The purpose of the article is to present self-control development technology meeting up-to-date requirements in the special education for pupils with mild mental retardation; to reveal the self-control special features for children of the studied category found during the experiment; to show necessity of the task-oriented work. Methods. The methods involve theoretical analysis of relevant psychologicpedagogical and methodical literature; empiric methods (conversation, writing tasks, observati...

  2. Epoxy Sol-Gel Hybrid Thermosets

    Directory of Open Access Journals (Sweden)

    Angels Serra

    2016-02-01

    Full Text Available Sol-gel methodologies are advantageous in the preparation of hybrid materials in front of the conventional addition of nanoparticles, because of the fine dispersion of the inorganic phase that can be reached in epoxy matrices. In addition, the use of organoalkoxysilanes as coupling agents allows covalent linkage between organic and inorganic phases, which is the key point in the improvement of mechanical properties. The sol-gel process involves hydrolysis and condensation reactions under mild conditions, starting from hydrolysable metal alkoxides, generally alkoxy silanes. Using the sol-gel procedure, the viscosity of the formulation is maintained, which is an important issue in coating applications, whereas the transparency of the polymer matrix is also maintained. However, only the proper combination of the chemistries and functionalities of both organic and inorganic structures leads to thermosets with the desired characteristics. The adequate preparation of hybrid epoxy thermosets enables their improvement in characteristics such as mechanical properties (modulus, hardness, scratch resistance, thermal and flame resistance, corrosion and antimicrobial protection, and even optical performance among others.

  3. What is the value of conducting a trial of r-tPA for the treatment of mild stroke patients?

    Science.gov (United States)

    Guzauskas, Gregory F; Chen, Er; Lalla, Deepa; Yu, Elaine; Tayama, Darren; Veenstra, David L

    2017-02-01

    Background The Phase IIIb, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Alteplase in Patients With Mild Stroke: Rapidly Improving Symptoms and Minor Neurologic Deficits (PRISMS) trial will assess r-tPA in ischemic stroke patients who present with mild deficits (i.e. mild stroke). Aims To assess PRISMS's societal value in clarifying the optimal care for patients with mild ischemic stroke. Methods A value of information (VOI) decision model was developed to compare the outcomes of mild stroke patients treated vs. not treated with r-tPA. Model inputs were derived from a subset of Third International Stroke Trial patients, a recent meta-analysis of r-tPA trials, expert opinion, and other published sources. VOI analyses were also used to assess the expected US societal value of the PRISMS trial and the expected value of reducing uncertainty in key trial estimates. Results The expected net societal value of the PRISMS trial was approximately $210 million ($160 m-$260 m), representing a six-fold return on investment. The value of reducing uncertainty in r-tPA efficacy was approximately $150 million ($100 m-$200 m), while reducing uncertainty in r-tPA safety (increased risk for symptomatic intracranial hemorrhage) did not add additional value in comparison. Conclusions Developing a better understanding of the outcomes of r-tPA treatment in patients with mild ischemic stroke will provide tremendous societal value by clarifying current uncertainty around treatment effectiveness. Enrollment in the PRISMS trial for patients presenting with mild ischemic stroke within 0-3 h of symptom onset should be highly encouraged.

  4. Silicone-containing aqueous polymer dispersions with hybrid particle structure.

    Science.gov (United States)

    Kozakiewicz, Janusz; Ofat, Izabela; Trzaskowska, Joanna

    2015-09-01

    In this paper the synthesis, characterization and application of silicone-containing aqueous polymer dispersions (APD) with hybrid particle structure are reviewed based on available literature data. Advantages of synthesis of dispersions with hybrid particle structure over blending of individual dispersions are pointed out. Three main processes leading to silicone-containing hybrid APD are identified and described in detail: (1) emulsion polymerization of organic unsaturated monomers in aqueous dispersions of silicone polymers or copolymers, (2) emulsion copolymerization of unsaturated organic monomers with alkoxysilanes or polysiloxanes with unsaturated functionality and (3) emulsion polymerization of alkoxysilanes (in particular with unsaturated functionality) and/or cyclic siloxanes in organic polymer dispersions. The effect of various factors on the properties of such hybrid APD and films as well as on hybrid particles composition and morphology is presented. It is shown that core-shell morphology where silicones constitute either the core or the shell is predominant in hybrid particles. Main applications of silicone-containing hybrid APD and related hybrid particles are reviewed including (1) coatings which show specific surface properties such as enhanced water repellency or antisoiling or antigraffiti properties due to migration of silicone to the surface, and (2) impact modifiers for thermoplastics and thermosets. Other processes in which silicone-containing particles with hybrid structure can be obtained (miniemulsion polymerization, polymerization in non-aqueous media, hybridization of organic polymer and polysiloxane, emulsion polymerization of silicone monomers in silicone polymer dispersions and physical methods) are also discussed. Prospects for further developments in the area of silicone-containing hybrid APD and related hybrid particles are presented.

  5. Operation management of daily economic dispatch using novel hybrid particle swarm optimization and gravitational search algorithm with hybrid mutation strategy

    Science.gov (United States)

    Wang, Yan; Huang, Song; Ji, Zhicheng

    2017-07-01

    This paper presents a hybrid particle swarm optimization and gravitational search algorithm based on hybrid mutation strategy (HGSAPSO-M) to optimize economic dispatch (ED) including distributed generations (DGs) considering market-based energy pricing. A daily ED model was formulated and a hybrid mutation strategy was adopted in HGSAPSO-M. The hybrid mutation strategy includes two mutation operators, chaotic mutation, Gaussian mutation. The proposed algorithm was tested on IEEE-33 bus and results show that the approach is effective for this problem.

  6. Hybrid-free Josephson Parametric Converter

    Science.gov (United States)

    Frattini, N. E.; Narla, A.; Sliwa, K. M.; Shankar, S.; Hatridge, M.; Devoret, M. H.

    A necessary component for any quantum computation architecture is the ability to perform efficient quantum operations. In the microwave regime of superconducting qubits, these quantum-limited operations can be realized with a non-degenerate Josephson junction based three-wave mixer, the Josephson Parametric Converter (JPC). Currently, the quantum signal of interest must pass through a lossy 180 degree hybrid to be presented as a differential drive to the JPC. This hybrid therefore places a limit on the quantum efficiency of the system and also increases the device footprint. We present a new design for the JPC eliminating the need for any external hybrid. We also show that this design has nominally identical performance to the conventional JPC. Work supported by ARO, AFOSR and YINQE.

  7. Hybrid Chernoff Tau-Leap

    KAUST Repository

    Moraes, Alvaro

    2014-01-06

    Markovian pure jump processes can model many phenomena, e.g. chemical reactions at molecular level, protein transcription and translation, spread of epidemics diseases in small populations and in wireless communication networks among many others. In this work we present a novel hybrid algorithm for simulating individual trajectories which adaptively switches between the SSA and the Chernoff tauleap methods. This allows us to: (a) control the global exit probability of any simulated trajectory, (b) obtain accurate and computable estimates for the expected value of any smooth observable of the process with minimal computational work.

  8. Hybrid Chernoff Tau-Leap

    KAUST Repository

    Moraes, Alvaro

    2015-01-07

    Markovian pure jump processes can model many phenomena, e.g. chemical reactions at molecular level, protein transcription and translation, spread of epidemics diseases in small populations and in wireless communication networks among many others. In this work we present a novel hybrid algorithm for simulating individual trajectories which adaptively switches between the SSA and the Chernoff tauleap methods. This allows us to: (a) control the global exit probability of any simulated trajectory, (b) obtain accurate and computable estimates for the expected value of any smooth observable of the process with minimal computational work.

  9. Hybrid Chernoff Tau-Leap

    KAUST Repository

    Moraes, Alvaro

    2016-01-06

    Markovian pure jump processes can model many phenomena, e.g. chemical reactions at molecular level, protein transcription and translation, spread of epidemics diseases in small populations and in wireless communication networks among many others. In this work we present a novel hybrid algorithm for simulating individual trajectories which adaptively switches between the SSA and the Chernoff tauleap methods. This allows us to: (a) control the global exit probability of any simulated trajectory, (b) obtain accurate and computable estimates for the expected value of any smooth observable of the process with minimal computational work.

  10. Extreme Environments Facilitate Hybrid Superiority – The Story of a Successful Daphnia galeata × longispina Hybrid Clone

    Science.gov (United States)

    Griebel, Johanna; Gießler, Sabine; Poxleitner, Monika; Navas Faria, Amanda; Yin, Mingbo; Wolinska, Justyna

    2015-01-01

    Hybridization within the animal kingdom has long been underestimated. Hybrids have often been considered less fit than their parental species. In the present study, we observed that the Daphnia community of a small lake was dominated by a single D. galeata × D. longispina hybrid clone, during two consecutive years. Notably, in artificial community set-ups consisting of several clones representing parental species and other hybrids, this hybrid clone took over within about ten generations. Neither the fitness assay conducted under different temperatures, or under crowded and non-crowded environments, nor the carrying capacity test revealed any outstanding life history parameters of this hybrid clone. However, under simulated winter conditions (i.e. low temperature, food and light), the hybrid clone eventually showed a higher survival probability and higher fecundity compared to parental species. Hybrid superiority in cold-adapted traits leading to an advantage of overwintering as parthenogenetic lineages might consequently explain the establishment of successful hybrids in natural communities of the D. longispina complex. In extreme cases, like the one reported here, a superior hybrid genotype might be the only clone alive after cold winters. Overall, superiority traits, such as enhanced overwintering here, might explain hybrid dominance in nature, especially in extreme and rapidly changing environments. Although any favoured gene complex in cyclic parthenogens could be frozen in successful clones independent of hybridization, we did not find similarly successful clones among parental species. We conclude that the emergence of the observed trait is linked to the production of novel recombined hybrid genotypes. PMID:26448651

  11. Hybrid Learning in Enhancing Communicative Skill in English

    Science.gov (United States)

    Singaravelu, G.

    2010-01-01

    The present study highlights the effectiveness of Hybrid-Learning in enhancing communicative skill in English among the Trainees of Bachelor of education of School of Distance Education, Bharathiar University,Coimbatore. Hybrid learning refers to mixing of different learning methods or mixing two more methods for teaching learning process. It…

  12. Supermarket Refrigeration System - Benchmark for Hybrid System Control

    DEFF Research Database (Denmark)

    Sloth, Lars Finn; Izadi-Zamanabadi, Roozbeh; Wisniewski, Rafal

    2007-01-01

    This paper presents a supermarket refrigeration system as a benchmark for development of new ideas and a comparison of methods for hybrid systems' modeling and control. The benchmark features switch dynamics and discrete valued input making it a hybrid system, furthermore the outputs are subjected...

  13. A Hybrid Aggressive Space Mapping Algorithm for EM Optimization

    DEFF Research Database (Denmark)

    Bakr, M.; Bandler, J. W.; Georgieva, N.;

    1999-01-01

    We present a novel, Hybrid Aggressive Space Mapping (HASM) optimization algorithm. HASM is a hybrid approach exploiting both the Trust Region Aggressive Space Mapping (TRASM) algorithm and direct optimization. It does not assume that the final space-mapped design is the true optimal design and is...

  14. Development of Traction Drive Motors for the Toyota Hybrid System

    Science.gov (United States)

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  15. New MPPT algorithm based on hybrid dynamical theory

    KAUST Repository

    Elmetennani, Shahrazed

    2014-11-01

    This paper presents a new maximum power point tracking algorithm based on the hybrid dynamical theory. A multiceli converter has been considered as an adaptation stage for the photovoltaic chain. The proposed algorithm is a hybrid automata switching between eight different operating modes, which has been validated by simulation tests under different working conditions. © 2014 IEEE.

  16. Hybrid viscous damper with filtered integral force feedback control

    DEFF Research Database (Denmark)

    Høgsberg, Jan; Brodersen, Mark L.

    2016-01-01

    In hybrid damper systems active control devices are usually introduced to enhance the performance of otherwise passive dampers. In the present paper a hybrid damper concept is comprised of a passive viscous damper placed in series with an active actuator and a force sensor. The actuator motion...

  17. [Analysis of allelic content of genes responsible for baking properties in allocytoplasmic wheat hybrids].

    Science.gov (United States)

    Klimushina, M V; Divashuk, M G; Mukhammed, T A K; Semenov, O G; Karlov, G I

    2013-05-01

    A collection comprised of allocytoplasmic hybrids of mild wheat (ACPH) was screened for the allelic state of genes responsible for baking properties (high-molecular glutenins, puroindolines, and Waxy). The possibility of the introgression of the Waxy gene of T. timopheevii into the mild wheat genome was demonstrated in several ACPH samples using the set of molecular markers. Allelic gene variants responsible for the baking properties were revealed for 22 ACPH samples, which make it possible to detect the most challenging samples for both molecular-genetic research and applied science.

  18. Research on Modulation Strategies Based on Multilevel Inverter Universal Hybrid Topology

    Institute of Scientific and Technical Information of China (English)

    Zhou Jinghua; Su Yanmin; Shen Chuanwen; Zhang Lin

    2005-01-01

    Based on multi-module-cascaded inverter topology, this study presented a universal multilevel inverter hybrid topology and unified the researches on multilevel inverter topology. According to the freedom of this universal topology, several new hybrid topologies were constructed. Also, based on conventional modulation strategies- multi-carrier SPWM (Sinusoidal Pulse Width Modulation), hybrid modulation strategies were introduced corresponding to hybrid topologies, and a multilevel SVPWM (Space Vector Pulse Width Modulation) technique based on phase-shifted theory was naturally produced. Simulation and experiment results prove that hybrid topologies and corresponding modulation strategies are valid, which lay a foundation for practical application of hybrid multilevel inverter topologies.

  19. Chronic mild stress impact: are females more vulnerable?

    Science.gov (United States)

    Dalla, C; Antoniou, K; Drossopoulou, G; Xagoraris, M; Kokras, N; Sfikakis, A; Papadopoulou-Daifoti, Z

    2005-01-01

    Despite the knowledge that women are more susceptible than men to stress-related mental illness, such as major depression, there is no comprehensive estimation of the role of gender in the detrimental effects of chronic stress that might cause depression. Sex differences regarding the association of behavioral parameters with serotonergic and hypothalamic-pituitary-adrenal axis activities were investigated in the chronic mild stress model of depression. Additionally, the impact of chronic mild stress exposure on an additional/novel short-term stressful procedure, such as the forced swim test was examined in male and female rats. Female rats were found to be more vulnerable to chronic mild stress and that was depicted with disruption of sucrose intake, decreases in open field activity, increased corticosterone levels, alteration in estrous cycle and decreased serotonergic activity in hippocampus and hypothalamus. On the contrary, in males the current chronic mild stress protocol elicited only behavioral changes, such as disruption in sucrose intake and decreased open field activity. Interestingly, in response to forced swim test, females previously subjected to chronic mild stress, were found to cope better by exhibiting increased active behavior in the second forced swim test session and higher hypothalamic serotonergic activity in comparison with corresponding males. On the other hand, males were more affected by previous chronic mild stress exposure and that was manifested by decreased active behavior in the first forced swim test session and increased corticosterone levels following second forced swim test session. These data indicate that although females are more vulnerable in the application of chronic mild stress than males, in response to an additional-novel stressor (forced swim test) they show better response. Therefore, both sex/gender and combination of stressful procedures should be carefully considered in the study of the pathophysiology of stress

  20. Acute urinary retention in a 23-year-old woman with mild encephalopathy with a reversible splenial lesion: a case report

    Directory of Open Access Journals (Sweden)

    Isobe Hideyuki

    2011-04-01

    Full Text Available Abstract Introduction Patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion present with relatively mild central nervous system disturbances. Although the exact etiology of the condition remains poorly understood, it is thought to be associated with infective agents. We present a case of a patient with mild encephalitis/encephalopathy with a reversible splenial lesion, who had the unusual feature of acute urinary retention. Case presentation A 23-year-old Japanese woman developed mild confusion, gait ataxia, and urinary retention seven days after onset of fever and headache. Magnetic resonance imaging demonstrated T2 prolongation in the splenium of the corpus callosum and bilateral cerebral white matter. These magnetic resonance imaging abnormalities disappeared two weeks later, and all of the symptoms resolved completely within four weeks. Except for the presence of acute urinary retention (due to underactive detrusor without hyper-reflexia, the clinical and radiologic features of our patient were consistent with those of previously reported patients with mild encephalitis/encephalopathy with a reversible splenial lesion. To the best of our knowledge, this is the first report of acute urinary retention recognized in a patient with mild encephalitis/encephalopathy with a reversible splenial lesion. Conclusion Our findings suggest that mild encephalitis/encephalopathy with a reversible splenial lesion can be associated with impaired bladder function and indicate that acute urinary retention in this benign disorder should be treated immediately to avoid bladder injury.

  1. The Hybrids of Postmodernism

    Directory of Open Access Journals (Sweden)

    Dana BĂDULESCU

    2014-09-01

    Full Text Available Hybridization is a fundamental characteristic of postmodernism, included by Ihab Hassan in his “catena” of features. This paper looks into the hybrids of postmodernism, which are the result of migration, displacement and uprooting, the re-visitation of myths, folklore and legends, or projections of their author’s imagination. The hybrids used as examples here are drawn from several novels written by Salman Rushdie, especially The Satanic Verses, two short stories, one by Márquez and the other by Donald Barthelme, Borges’s Book of Imaginary Beings, Cărtărescu’s Encyclopaedia of Dragons and Michelle Cliff’s No Telephone to Heaven. Diverse as they may be, these hybrids emphasize a defining characteristic of postmodernism, which is its pluralism. I conclude that the hybrids of postmodernism are aesthetically or politically subversive. Besides, what makes them difficult to grasp is their unfixed and protean nature. They ask for high leaps of the imagination, a total suspension of disbelief and a complete surrender to the powerful seduction of imagination on the reader’s part.

  2. 10p Duplication characterized by fluorescence in situ hybridization

    Energy Technology Data Exchange (ETDEWEB)

    Wiktor, A.; Feldman, G.L.; Van Dyke, D.L.; Kratkoczki, P.; Ditmars, D.M. Jr. [Henry Ford Hospital, Detroit, MI (United States)

    1994-09-01

    We describe a patient with severe failure to thrive, mild-moderate developmental delay, cleft lip and palate, and other anomalies. Routine cytogenetic analysis documented a de novo chromosome rearrangement involving chromosome 4, but the origin of the derived material was unknown. Using chromosome specific painting probes, the karyotype was defined as 46,XY,der(4)t(4;10)(q35;p11.23). Characterization of the dup(10p) by fluorescence in situ hybridization (FISH) analysis provides another example of the usefulness of this technology in identifying small deletions, duplications, or supernumerary marker chromosomes. 19 refs., 4 figs.

  3. Research on Hybrid Vehicle Drivetrain

    Science.gov (United States)

    Xie, Zhongzhi

    Hybrid cars as a solution to energy saving, emission reduction measures, have received widespread attention. Motor drive system as an important part of the hybrid vehicles as an important object of study. Based on the hybrid electric vehicle powertrain control system for permanent magnet synchronous motor as the object of study. Can be applied to hybrid car compares the characteristics of traction motors, chose permanent magnet synchronous Motors as drive motors for hybrid vehicles. Building applications in hybrid cars in MATLAB/Simulink simulation model of permanent-magnet synchronous motor speed control system and analysis of simulation results.

  4. Clinical and molecular characterization of two patients with overlapping de novo microdeletions in 2p14-p15 and mild mental retardation

    DEFF Research Database (Denmark)

    Wohlleber, Eva; Kirchhoff, Eva Maria; Zink, Alexander M

    2011-01-01

    Here, we present two patients with overlapping de novo microdeletions in chromosome 2p14-p15, mild mental retardation concerning especially language development, as well as mild dysmorphic features. Patient 1 also presented with generalized seizures, sensorineural hearing loss, and relative...... genes, several of which have functions in neuronal development. This report illustrates the power of databases such as DECIPHER and MRNET in assessing the pathogenicity of copy-number variations (CNVs)....

  5. The Characterization of Biological Rhythms in Mild Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Elisabet Ortiz-Tudela

    2014-01-01

    Full Text Available Introduction. Patients with dementia, especially Alzheimer’s disease, present several circadian impairments related to an accelerated perturbation of their biological clock that is caused by the illness itself and not merely age-related. Thus, the objective of this work was to elucidate whether these circadian system alterations were already present in patients with mild cognitive impairment (MCI, as compared to healthy age-matched subjects. Methods. 40 subjects (21 patients diagnosed with MCI, 74.1 ± 1.5 y.o., and 19 healthy subjects, 71.7 ± 1.4 y.o. were subjected to ambulatory monitoring, recording wrist skin temperature, motor activity, body position, and the integrated variable TAP (including temperature, activity, and position for one week. Nonparametrical analyses were then applied. Results. MCI patients exhibited a significant phase advance with respect to the healthy group for the following phase markers: temperature M5 (mean ± SEM: 04:20 ± 00:21 versus 02:52 ± 00:21 and L10 (14:35 ± 00:27 versus 13:24 ± 00:16 and TAP L5 (04:18 ± 00:14 versus 02:55 ± 00:30 and M10 (14:30 ± 00:18 versus 13:28 ± 00:23. Conclusions. These results suggest that significant advances in the biological clock begin to occur in MCI patients, evidenced by an accelerated aging of the circadian clock, as compared to a healthy population of the same age.

  6. Biomimetic growth of gallic acid-ZnO hybrid assemblies and their applications

    Energy Technology Data Exchange (ETDEWEB)

    Sarker, Nazmul H.; Barnaby, Stacey N. [Fordham University, Department of Chemistry (United States); Fath, Karl R. [City University of New York and Graduate Center, Department of Biology, Queens College (United States); Frayne, Stephen H.; Nakatsuka, Nako; Banerjee, Ipsita A., E-mail: banerjee@fordham.edu [Fordham University, Department of Chemistry (United States)

    2012-03-15

    In this study, we probed the biomimetic formation of gallic acid (GA)-ZnO nanoparticle hybrids. It was found that the morphologies formed were dependent upon pH values, resulting in GA-ZnO hybrids of varying shapes such as micro or nanoplates or fibers. The formed supramolecular GA-ZnO hybrids were found to be luminescent as indicated by confocal microscopy and were utilized for the photocatalytic degradation of the organic dye methylene blue. We also explored the bactericidal effects of the hybrids on Staphylococcus aureus (S. aureus) as well as Escherichia Coli (E. Coli). Thus, we have developed a new class of shape-controlled nanohybrid assemblies via mild, green synthetic methods that may be utilized for photocatalytic degradation for environmental remediation as well as for antibacterial applications.

  7. Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes.

    Science.gov (United States)

    Kato, Shota; Saga, Yutaka; Kojima, Masahiro; Fuse, Hiromu; Matsunaga, Shigeki; Fukatsu, Arisa; Kondo, Mio; Masaoka, Shigeyuki; Kanai, Motomu

    2017-02-15

    Hybrid catalyst systems to achieve acceptorless dehydrogenation of N-heterocycles and tetrahydronaphthalenes-model substrates for liquid organic hydrogen carriers-were developed. A binary hybrid catalysis comprising an acridinium photoredox catalyst and a Pd metal catalyst was effective for the dehydrogenation of N-heterocycles, whereas a ternary hybrid catalysis comprising an acridinium photoredox catalyst, a Pd metal catalyst, and a thiophosphoric imide organocatalyst achieved dehydrogenation of tetrahydronaphthalenes. These hybrid catalyst systems allowed for 2 molar equiv of H2 gas release from six-membered N-heterocycles and tetrahydronaphthalenes under mild conditions, i.e., visible light irradiation at rt. The combined use of two or three different catalyst types was essential for the catalytic activity.

  8. for hybrid dynamical systems

    Directory of Open Access Journals (Sweden)

    Wassim M. Haddad

    2001-01-01

    Full Text Available In this paper we develop a unified dynamical systems framework for a general class of systems possessing left-continuous flows; that is, left-continuous dynamical systems. These systems are shown to generalize virtually all existing notions of dynamical systems and include hybrid, impulsive, and switching dynamical systems as special cases. Furthermore, we generalize dissipativity, passivity, and nonexpansivity theory to left-continuous dynamical systems. Specifically, the classical concepts of system storage functions and supply rates are extended to left-continuous dynamical systems providing a generalized hybrid system energy interpretation in terms of stored energy, dissipated energy over the continuous-time dynamics, and dissipated energy over the resetting events. Finally, the generalized dissipativity notions are used to develop general stability criteria for feedback interconnections of left-continuous dynamical systems. These results generalize the positivity and small gain theorems to the case of left-continuous, hybrid, and impulsive dynamical systems.

  9. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Rönnkö, M.; Ravn, Anders Peter; Sere, K.

    2003-01-01

    In this paper we investigate the use of action systems with differential actions in the specifcation of hybrid systems. As the main contribution we generalize the definition of a differential action, allowing the use of arbitrary relations over model variables and their time-derivatives in modell......In this paper we investigate the use of action systems with differential actions in the specifcation of hybrid systems. As the main contribution we generalize the definition of a differential action, allowing the use of arbitrary relations over model variables and their time...... parallel composition. Moreover, as the strength of the action system formalism is the support for stepwise development by refinement, we investigate refinement involving a differential action. We show that, due to the predicate transformer semantics, standard action refinement techniques apply also...... to the differential action, thus, allowing stepwise development of hybrid systems Udgivelsesdato: JAN 1...

  10. Conditional Hybrid Nonclassicality

    Science.gov (United States)

    Agudelo, E.; Sperling, J.; Costanzo, L. S.; Bellini, M.; Zavatta, A.; Vogel, W.

    2017-09-01

    We derive and implement a general method to characterize the nonclassicality in compound discrete- and continuous-variable systems. For this purpose, we introduce the operational notion of conditional hybrid nonclassicality which relates to the ability to produce a nonclassical continuous-variable state by projecting onto a general superposition of discrete-variable subsystem. We discuss the importance of this form of quantumness in connection with interfaces for quantum communication. To verify the conditional hybrid nonclassicality, a matrix version of a nonclassicality quasiprobability is derived and its sampling approach is formulated. We experimentally generate an entangled, hybrid Schrödinger cat state, using a coherent photon-addition process acting on two temporal modes, and we directly sample its nonclassicality quasiprobability matrix. The introduced conditional quantum effects are certified with high statistical significance.

  11. Porosity in hybrid materials

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, D.W.; Beaucage, G.; Loy, D. [Sandia National Labs., Albuquerque, NM (United States)

    1995-12-31

    Multicomponent, or hybrid composites are emerging as precursors to porous materials. Sacrifice of an ephemeral phase can be used to generate porosity, the nature of which depends on precursor structure. Retention of an organic constituent, on the other hand, can add desirable toughness to an otherwise brittle ceramic. We use small-angle x-ray and neutron scattering to examine porosity in both simple and hybrid materials. We find that microphase separation controls porosity in almost all systems studied. Pore distributions are controlled by the detailed bonding within and between phases as well as the flexibility of polymeric constituents. Thus hybridization opens new regions of pore distributions not available in simple systems. We look at several sacrificial concepts and show that it is possible to generate multimodal pore size distributions due to the complicated phase structure in the precursor.

  12. Photoproduction of Hybrid Mesons

    CERN Document Server

    Barnes, T

    1998-01-01

    In this contribution I discuss prospects for photoproducing hybrid mesons at CEBAF, based on recent model results and experimental indications of possible hybrids. One excellent opportunity appears to be a search for the I=1, JPC=2+-, neutral "(b2)o" hybrid in (a2 pi)o through diffractive photoproduction. Other notable possibilities accessible through pi+ or pio exchange photoproduction are I=1, JPC=1-+, charged "pi1+" in f1 pi+, (b1 pi)+ and (rho pi)+; piJ(1770)+ in f2 pi+ and (b1 pi)+; pi(1800)+ in f0 pi+, f2 pi+, omega rho+ and (rho pi)+; a1 in f1 pi+ and f2 pi+; and omega in (rho pi)o, omega eta and (K1 K)o.

  13. Self-Assembled PbSe Nanowire:Perovskite Hybrids.

    Science.gov (United States)

    Yang, Zhenyu; Yassitepe, Emre; Voznyy, Oleksandr; Janmohamed, Alyf; Lan, Xinzheng; Levina, Larissa; Comin, Riccardo; Sargent, Edward H

    2015-12-02

    Inorganic semiconductor nanowires are of interest in nano- and microscale photonic and electronic applications. Here we report the formation of PbSe nanowires based on directional quantum dot alignment and fusion regulated by hybrid organic-inorganic perovskite surface ligands. All material synthesis is carried out at mild temperatures. Passivation of PbSe quantum dots was achieved via a new perovskite ligand exchange. Subsequent in situ ammonium/amine substitution by butylamine enables quantum dots to be capped by butylammonium lead iodide, and this further drives the formation of a PbSe nanowire superlattice in a two-dimensional (2D) perovskite matrix. The average spacing between two adjacent nanowires agrees well with the thickness of single atomic layer of 2D perovskite, consistent with the formation of a new self-assembled semiconductor nanowire:perovskite heterocrystal hybrid.

  14. Self-Assembled PbSe Nanowire:Perovskite Hybrids

    KAUST Repository

    Yang, Zhenyu

    2015-12-02

    © 2015 American Chemical Society. Inorganic semiconductor nanowires are of interest in nano- and microscale photonic and electronic applications. Here we report the formation of PbSe nanowires based on directional quantum dot alignment and fusion regulated by hybrid organic-inorganic perovskite surface ligands. All material synthesis is carried out at mild temperatures. Passivation of PbSe quantum dots was achieved via a new perovskite ligand exchange. Subsequent in situ ammonium/amine substitution by butylamine enables quantum dots to be capped by butylammonium lead iodide, and this further drives the formation of a PbSe nanowire superlattice in a two-dimensional (2D) perovskite matrix. The average spacing between two adjacent nanowires agrees well with the thickness of single atomic layer of 2D perovskite, consistent with the formation of a new self-assembled semiconductor nanowire:perovskite heterocrystal hybrid.

  15. Biomarkers for dementia and mild cognitive impairment in Parkinson's disease.

    Science.gov (United States)

    Delgado-Alvarado, Manuel; Gago, Belén; Navalpotro-Gomez, Irene; Jiménez-Urbieta, Haritz; Rodriguez-Oroz, María C

    2016-06-01

    Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's disease. Around 30% of patients with Parkinson's disease experience mild cognitive impairment, a well-established risk factor for the development of dementia. However, mild cognitive impairment in patients with Parkinson's disease is a heterogeneous entity that involves different types and extents of cognitive deficits. Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions. In this sense, the identification among patients with Parkinson's disease and mild cognitive impairment of biomarkers associated with dementia would allow the early detection of this process. This review summarizes studies from the past 25 years that have assessed the potential biomarkers of dementia and mild cognitive impairment in Parkinson's disease patients. Despite the potential importance, no biomarker has as yet been validated. However, features such as low levels of epidermal and insulin-like growth factors or uric acid in plasma/serum and of Aß in CSF, reduction of cerebral cholinergic innervation and metabolism measured by PET mainly in posterior areas, and hippocampal atrophy in MRI might be indicative of distinct deficits with a distinct risk of dementia in subgroups of patients. Longitudinal studies combining the existing techniques and new approaches are needed to identify patients at higher risk of dementia. © 2016 International Parkinson and Movement Disorder Society.

  16. Smart hybrid rotary damper

    Science.gov (United States)

    Yang, C. S. Walter; DesRoches, Reginald

    2014-03-01

    This paper develops a smart hybrid rotary damper using a re-centering smart shape memory alloy (SMA) material as well as conventional energy-dissipating metallic plates that are easy to be replaced. The ends of the SMA and steel plates are inserted in the hinge. When the damper rotates, all the plates bend, providing energy dissipating and recentering characteristics. Such smart hybrid rotary dampers can be installed in structures to mitigate structural responses and to re-center automatically. The damaged energy-dissipating plates can be easily replaced promptly after an external excitation, reducing repair time and costs. An OpenSEES model of a smart hybrid rotary was established and calibrated to reproduce the realistic behavior measured from a full-scale experimental test. Furthermore, the seismic performance of a 3-story moment resisting model building with smart hybrid rotary dampers designed for downtown Los Angeles was also evaluated in the OpenSEES structural analysis software. Such a smart moment resisting frame exhibits perfect residual roof displacement, 0.006", extremely smaller than 18.04" for the conventional moment resisting frame subjected to a 2500 year return period ground motion for the downtown LA area (an amplified factor of 1.15 on Kobe earthquake). The smart hybrid rotary dampers are also applied into an eccentric braced steel frame, which combines a moment frame system and a bracing system. The results illustrate that adding smart hybrid rotaries in this braced system not only completely restores the building after an external excitation, but also significantly reduces peak interstory drifts.

  17. Design and synthesis of organic-inorganic hybrid capsules for biotechnological applications.

    Science.gov (United States)

    Shi, Jiafu; Jiang, Yanjun; Wang, Xiaoli; Wu, Hong; Yang, Dong; Pan, Fusheng; Su, Yanlei; Jiang, Zhongyi

    2014-08-07

    Organic-inorganic hybrid capsules, which typically possess a hollow lumen and a hybrid wall, have emerged as a novel and promising class of hybrid materials and have attracted enormous attention. In comparison to polymeric capsules or inorganic capsules, the hybrid capsules combine the intrinsic physical/chemical properties of the organic and inorganic moieties, acquire more degrees of freedom to manipulate multiple interactions, create hierarchical structures and integrate multiple functionalities. Thus, the hybrid capsules exhibit superior mechanical strength (vs. polymeric capsules) and diverse functionalities (vs. inorganic capsules), which may give new opportunities to produce high-performance materials. Much effort has been devoted to exploring innovative and effective methods for the synthesis of hybrid capsules that exhibit desirable performance in target applications. This tutorial review firstly presents a brief description of the capsular structure and hybrid materials in nature, then classifies the hybrid capsules into molecule-hybrid capsules and nano-hybrid capsules based upon the size of the organic and inorganic moieties in the capsule wall, followed by a detailed discussion of the design and synthesis of the hybrid capsules. For each kind of hybrid capsule, the state-of-the-art synthesis methods are described in detail and a critical comment is embedded. The applications of these hybrid capsules in biotechnological areas (biocatalysis, drug delivery, etc.) have also been summarized. Hopefully, this review will offer a perspective and guidelines for the future research and development of hybrid capsules.

  18. Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database

    Science.gov (United States)

    Lee, Hyun; Rhee, Chin Kook; Lee, Byung-Jae; Choi, Dong-Chull; Kim, Jee-Ae; Kim, Sang Hyun; Jeong, Yoolwon; Kim, Tae-Hyung; Chon, Gyu Rak; Jung, Ki-Suck; Lee, Sang Haak; Price, David; Yoo, Kwang Ha; Park, Hye Yun

    2016-01-01

    Background Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD. Methods Patients with mild-to-moderate COPD (≥40 years) were extracted from Korean National Health and Nutrition Examination Survey data (2007–2012) and were linked to the national health insurance reimbursement database to obtain medical service utilization records. Results Of the 2,397 patients with mild-to-moderate COPD, 111 (4.6%) had severe exacerbations over the 6 years (0.012/person-year). Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only COPD patients (P<0.001). A multiple logistic regression presented that asthma was an independent risk factor of severe exacerbations in patients with mild-to-moderate COPD regardless of adjustment for all possible confounding factors (adjusted odds ratio, 1.67; 95% confidence interval, 1.002–2.77, P=0.049). In addition, age, female, poor lung function, use of inhalers, and low EuroQoL five dimensions questionnaire index values were independently associated with severe exacerbation in patients with mild-to-moderate COPD. Conclusion In this population-based study, the prevalence of severe exacerbations in patients with mild-to-moderate COPD was relatively low, compared with previous clinical interventional studies. Coexisting asthma significantly impacted the frequency of severe exacerbations in patients with mild-to-moderate COPD, suggesting application of an exacerbation preventive strategy in these patients. PMID:27143869

  19. Analog and hybrid computing

    CERN Document Server

    Hyndman, D E

    2013-01-01

    Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

  20. Hybrid Weyl semimetal

    Science.gov (United States)

    Li, Fei-Ye; Luo, Xi; Dai, Xi; Yu, Yue; Zhang, Fan; Chen, Gang

    2016-09-01

    We construct a tight-binding model realizing one pair of Weyl nodes and three distinct Weyl semimetals. In the type-I (type-II) Weyl semimetal, both nodes belong to type-I (type-II) Weyl nodes. In addition, there exists a third type, previously undiscovered and dubbed "hybrid Weyl semimetal", in which one Weyl node is of type I while the other is of type II. For the hybrid Weyl semimetal, we further demonstrate the bulk Fermi surfaces and the topologically protected surface states, analyze the unique Landau-level structure and quantum oscillation, and discuss the conditions for possible material realization.