Sample records for milan komrek vladimr
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Optimal football strategies: AC Milan versus FC Barcelona
Papahristodoulou, Christos
2012-01-01
In a recent UEFA Champions League game between AC Milan and FC Barcelona, played in Italy (final score 2-3), the collected match statistics, classified into four offensive and two defensive strategies, were in favour of FC Barcelona (by 13 versus 8 points). The aim of this paper is to examine to what extent the optimal game strategies derived from some deterministic, possibilistic, stochastic and fuzzy LP models would improve the payoff of AC Milan at the cost of FC Barcelona.
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Milan Kundera poeediparukaga faun / Kärt Hellerma
Hellerma, Kärt, 1956-
1996-01-01
Arvustus: Kundera, Milan. Surematus. Tln. : Monokkel, 1995. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 176-179
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Zemřel JUDr. Milan Princ (1926-2016)
Czech Academy of Sciences Publication Activity Database
Nechvátal, Bořivoj; Šlesingerová, Lada
2016-01-01
Roč. 76, č. 5 (2016), s. 554-556 ISSN 1210-5538 Institutional support: RVO:67985912 Keywords : Milan Princ * archaeology * historic preservation * obituary * personal bibliography Subject RIV: AC - Archeology, Anthropology, Ethnology
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„Diderot miloval mystifikace“, a co Milan Kundera?
Czech Academy of Sciences Publication Activity Database
Jungmannová, Lenka
2017-01-01
Roč. 65, č. 2 (2017), s. 235-256 ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : Czech drama * Kundera, Milan * Steigerwald, Karel Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Specific literatures
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Evolution of Milan microclimate in XX century
International Nuclear Information System (INIS)
Schieroni, A.
1993-01-01
Within the framework of studies to correlate the use of fossil fuels with urban area thermal pollution, this article examines the local microclimate of Milan, describing the main features of the so-called 'heat island' phenomenon and analyzing the evolution of ambient temperatures. Two different kinds of data on urban temperatures were employed: the hourly measurements taken by the Multinational Presidium for Hygiene and Prevention, run by the Local Sanitary Unit No. 75 of Milan, in the period ranging from 1985 to 1990, and the maximum and minimum daily values referring to the period between 1909 and 1991 (data supplied by the Meteorologic Observatory of Brera-Duomo). The standard year, worked out in the framework of the C. N. R. (National Research Centre) Finalized Energy Project and referring to the meteorological station of Linate Airport, was employed in order to highlight the difference between the thermal behaviour of the urban and the extra-urban area
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Early Greek Typography in Milan: A Historical Note on a New Greek Typeface.
Wallraff, Martin
1997-01-01
Discusses the history of Greek typography, focusing on the first book to be entirely printed in Greek in 1476 and the series of new typefaces that resulted. Cites Milan as a center of Greek printing in the early history of Greek typography. Describes a revival of one of these typefaces created under the name of Milan Greek. (PA)
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[Public food service in Milan city and Hinterland: GMP application (Part 1)].
Pontello, M; Dal Vecchio, A; Bertini, I; Valerio, E
2005-01-01
Food service establishments are recognized as a critical sector concerning foodborne diseases occurrence, that is associated to contributing factors such as the anticipated preparation of meals that are often highly handled, and long-time distributed. A survey has been planned to evaluate the application of HACCP plan, in order to select a statistically representative sample of food services (restaurant, pizza-shop, bar, ..) in two Milan area' Public Health Units (PHU). During the inspections a proper check-list has been filled up in order to give a conformity evaluation about the global situation and about three specific sections: hygiene of food-handlers, procedures control, temperatures management. The food services have been found satisfactory in 9/106 and 5/54 cases in Milan City and in hinterland, respectively; among the two areas, highly significant differences have been revealed about temperatures management (68% and 28% unsatisfactory, respectively). In Milan City restaurants provided with HACCP plan scores are significantly different from unprovided restaurants scores (global and the three sections' evaluation); in Milan hinterland differences between provided and unprovided HACCP plan restaurants regard temperature management scores only. Useful suggestions to improve the quality of surveillance activity come from complex and heterogeneous findings shown in this study.
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Mass gatherings in Italy: a study from the 2015 Milan Expo
Directory of Open Access Journals (Sweden)
Pietro Marino
2016-07-01
Full Text Available Introduction. A mass gathering (MG is when a large number of people come together in a particular location for a specific purpose. Expo 2015 was an universal exposition hosted by Milan, Italy. The Pre-Hospital Emergency Company (AREU of Lombardy Region (Milan-Italy was involved in planning and managing the emergency rescue response inside the Expo 2015 area in Milan. In this paper, we review the AREU medical and public health response for the 2015 Milan Expo. Methods. Existing risk-assessment processes for MGs were used (the Arbon Predictive Score and Maurer Score to define the expected resources and the impact on the health systems. The objective of the plan was to reduce the impact of the event by adopting the model of First Aid Points (advanced medical posts deployed in the event site acting as ‘first health filters’ for the hospital network in Milan. Results. Our data indicate that 13,579 visitors were rescued in the ‘Red Area’ from 1 May to 31 October (with an average of 73 cases per day; 9,501 of them needed initial treatment or observation time at the First Aid Points, 1,289 of them were hospitalised (1% Red code, 29% Yellow code, 70% Green code; 65% of patients (57% female, with a mean age of 37 years old had medical problems. Fatigue, light- headedness, dizziness, syncope, loss of consciousness and headache were the prevalent medical diagnoses. Conclusions. Our study confirms that environmental factors, such as the weather, can contribute to large numbers of ill people at MGs. Overall, the AREU of Lombardy Region demonstrated excellent preparation for the Expo 2015 MG. Flexibility, integration and strong cooperation between the pre-hospital settings and hospitals were incorporated into the application of the plan. The final data showed the effectiveness of the adopted model and the reduced impact on the hospital network.
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Turistički značaj galerije 'Milan Konjović' u Somboru
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Besermenji Snežana
2008-01-01
Full Text Available A gallery 'Milan Konjović' in Sombor is a culture establishment in which there are exhibited works of a famous impressionist Milan Konjovic. It was opened in 1966 and it is placed in a Galley house, on the Square of Holy Three. Works of Milan Konjović are presented by chronological productions and occasional thematic exhibitions, and a collection consists of 1060 works today. In order to notice the tourist importance of this establishment, in this work there will be done a SWOT analysis which will point to internal abilities and internal weakness on one hand and, on the other hand, there will be analyzed exterior possibilities and those are chances and threats from the surroundings. Considering the fact that conditions in our institutions of culture are on unsatisfactory level, in this paper two affirmed galleries in London will be presented: the Tate Gallery and the Tate Modern, which represent positive example of successful management in cultural institutions.
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Altered Rhythms. Urban façades in post-war Milan
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Magda Mària Serrano
2017-10-01
Full Text Available Urban façades are the outward manifestation of the character of a city, and are composed of elements that respond to rhythmic sequences in consonance with the internal order of the rooms behind them. In post-war Milan, façades were used as a field of experimentation by a group of architects, some of whom were also artists and designers, who saw themselves and can be seen as ambassadors for the future modernity of a city devastated by war. This article explains how the urban façades of Milan, based as they were on the themes drawn from the Italian compositional tradition, offer a wide variety of elements, figures and rhythms, altering and transgressing the compositional canons through the use of mechanisms that in some cases are closer to painting or sculpture than to architecture.
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Progress report on the Milan superconducting cyclotron
International Nuclear Information System (INIS)
Acerbi, E.; Alessandria, F.; Baccaglioni, G.; Bellomo, G.; Birattari, C.; Bosotti, A.; Broggi, F.; Cortesi, G.; DeMartinis, C.; Fabrici, E.; Ferrari, A.; Giove, D.; Giussani, A.; Giussani, W.; Michelato, P.; Pagani, C.; Rivoltella, G.; Rossi, L.; Serafini, L.; Sussetto, A.; Torri, V.; Varisco, G.; Cuttone, G.; Raia, G.; Kai, L.
1988-01-01
This paper reports on the construction of the K800 superconducting cyclotron at the University of Milan underway since February 1981. The delay in the construction of the new building and a defect of the weldings of the helium vessel have caused a shift in the project schedule of about two years. Currently, the cyclotron magnet and the cryogenic plant have been completed and installed. First operation of the magnet and magnetic field mapping are to begin shortly
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Radiation protection courses in the Milan Copic Nuclear Training Centre
International Nuclear Information System (INIS)
Kozelj, M.; Stritar, A.
1998-01-01
We have briefly described the legal framework for the radiation protection training in Slovenia. The history of that activity at the Milan Copic Nuclear Training Center in Ljubljana is than described with the detailed description and summary of all performed courses.(author)
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Kim, Young; Stahl, Christopher C; Makramalla, Abouelmagd; Olowokure, Olugbenga O; Ristagno, Ross L; Dhar, Vikrom K; Schoech, Michael R; Chadalavada, Seetharam; Latif, Tahir; Kharofa, Jordan; Bari, Khurram; Shah, Shimul A
2017-12-01
Orthotopic liver transplantation is a curative treatment for hepatocellular carcinoma within Milan criteria, but these criteria preclude many patients from transplant candidacy. Recent studies have demonstrated that downstaging therapy can reduce tumor burden to meet conventional criteria. The present study reports a single-center experience with tumor downstaging and its effects on post-orthotopic liver transplantation outcomes. All patients with hepatocellular carcinoma who were evaluated by our multidisciplinary liver services team from 2012 to 2016 were identified (N = 214). Orthotopic liver transplantation candidates presenting outside of Milan criteria at initial radiographic diagnosis and/or an initial alpha-fetoprotein >400 ng/mL were categorized as at high risk for tumor recurrence and post-transplant mortality. Of the 214 patients newly diagnosed with hepatocellular carcinoma, 73 (34.1%) eventually underwent orthotopic liver transplantation. The majority of patients who did not undergo orthotopic liver transplantation were deceased or lost to follow-up (47.5%), with 14 of 141 (9.9%) currently listed for transplantation. Among transplanted patients, 21 of 73 (28.8%) were considered high-risk candidates. All 21 patients were downstaged to within Milan criteria with an alpha-fetoprotein hepatocellular carcinoma was higher but acceptable between downstaged high-risk and traditional candidates (9.5% vs 1.9%; P > .05) at a median follow-up period of 17 months. Downstaged high-risk candidates had a similar overall survival compared with those transplanted within Milan criteria (log-rank P > .05). In highly selected cases, patients with hepatocellular carcinoma outside of traditional criteria for orthotopic liver transplantation may undergo downstaging therapy in a multidisciplinary fashion with excellent post-transplant outcomes. These data support an aggressive downstaging approach for selected patients who would otherwise be deemed ineligible for
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Hearn, Elizabeth H.; Koltermann, Christine; Rubinstein, Justin R.
2018-01-01
We have developed groundwater flow models to explore the possible relationship between wastewater injection and the 12 November 2014 Mw 4.8 Milan, Kansas earthquake. We calculate pore pressure increases in the uppermost crust using a suite of models in which hydraulic properties of the Arbuckle Formation and the Milan earthquake fault zone, the Milan earthquake hypocenter depth, and fault zone geometry are varied. Given pre‐earthquake injection volumes and reasonable hydrogeologic properties, significantly increasing pore pressure at the Milan hypocenter requires that most flow occur through a conductive channel (i.e., the lower Arbuckle and the fault zone) rather than a conductive 3‐D volume. For a range of reasonable lower Arbuckle and fault zone hydraulic parameters, the modeled pore pressure increase at the Milan hypocenter exceeds a minimum triggering threshold of 0.01 MPa at the time of the earthquake. Critical factors include injection into the base of the Arbuckle Formation and proximity of the injection point to a narrow fault damage zone or conductive fracture in the pre‐Cambrian basement with a hydraulic diffusivity of about 3–30 m2/s. The maximum pore pressure increase we obtain at the Milan hypocenter before the earthquake is 0.06 MPa. This suggests that the Milan earthquake occurred on a fault segment that was critically stressed prior to significant wastewater injection in the area. Given continued wastewater injection into the upper Arbuckle in the Milan region, assessment of the middle Arbuckle as a hydraulic barrier remains an important research priority.
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The Milan Project: a newborn hearing screening programme.
Pastorino, Giancarlo; Sergi, Paola; Mastrangelo, Massimo; Ravazzani, Paolo; Tognola, Gabriella; Parazzini, Marta; Mosca, Fabio; Pugni, Lorenza; Grandori, Ferdinando
2005-04-01
Since 1997 a newborn hearing screening programme has been implemented by the U.O. Neurologia-Neurofisiopatologia and Dipartimento di Neonatologia of the Istituti Clinici di Perfezionamento ICP in Milan for both babies with no risk and those at risk of hearing impairment. This programme was named the Milan Project. The protocol for no-risk babies consisted of three stages: in the first two stages, newborns were tested with transient click-evoked otoacoustic emissions (TEOAE), in the third one with conventional auditory brainstem responses (ABR). The first TEOAE test was performed by 36 h of age, before discharge, the second one after 15-30 d in case of referral, and the third one, by ABR, for those babies who failed the second TEOAE stage. Newborns at audiological risk were submitted to conventional ABR before the third month of corrected age. Some of this latter population was also submitted to the TEOAE test. The entire tested population (no-risk babies and newborns at audiological risk) consisted of 19 777 babies: 19 290 without risk ("no risk") and 487 at risk ("at risk"). During the course of the Milan Project, hearing impairment (ABR threshold equal to or greater than 40 dB nHL) was identified in 63 newborns (19 from the no-risk and 44 from the at-risk population), with a prevalence of 0.32%. Bilateral hearing impairment (BHI) was found in 33 newborns (10 from the no-risk and 23 from the at-risk population), corresponding to 0.17%. Among infants with bilateral hearing impairment, 30.3% had no risk factors. The prevalence of hearing impairment was determined on days 15-30 after birth. The results show that the implementation of a hospital-based, universal neonatal hearing screening programme for babies with and without audiological risk is feasible and effective. The effectiveness of the programme has increased as a function of the years since its inception, with a strong decrease in the referral rate. Further improvement is obtained if the TEOAE measurements
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Violencia y memoria en Milan Kundera
Tafalla, Marta
2007-01-01
Partiendo de la filosofía de la memoria de T. W. Adorno, este artículo defiende la tesis de que la literatura tiene una mayor capacidad que la historia o la filosofía para explicar en qué consisten los regímenes totalitarios y para salvaguardar la memoria de sus víctimas. Con este propósito, toma como ejemplo la literatura del escritor checo Milan Kundera y analiza algunas de sus obras, especialmente El libro de la risa y el olvido, La insoportable levedad del ser y su ensayo El arte de la no...
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Active and passive monitoring of benzene in Milan from 1992 up to today
International Nuclear Information System (INIS)
Lerda, D.; Robles, P.; Astori, M.; Barletta, M.; Canzi, R.; Barilli, L.
1999-01-01
The air quality degradation in large urban areas, mainly due to the traffic, is evaluated through the measurement of pollutants coming, directly or indirectly, from the traffic itself. Due to its cancerogenicity, a quality standard for benzene has been settled by D.M.25/11/1994, which obliges this measure in towns having more than 150.000 inhabitants.Starting from 1992, Milan P.M.I.P. has been controlling benzene and other homologues concentrations in air with routine and campaign measurements. Concentrations change depends both on variations of fuel formulation and on the renewal of the cars fleet. As a matter of fact, the lower benzene percentage in fuels and the use of tailpipes with catalytic converter greatly reduced the emission of these compounds in air, giving an estimate annual average lower than the impose limit. In an urban area, an estimate of an average concentration starting from the three sampling points according to the low can give a value far from the real average level; to solve this problem Milan P.M.I.P. programmed an annual campaign with daily sampling in 24 sites homogeneously located in Milan territory [it
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Milan Rezo, PhD in Technical Sciences
Directory of Open Access Journals (Sweden)
Tomislav Bašić
2010-12-01
Full Text Available On October, 7th 2010, Milan Rezo defended his dissertation The Meaning and the Application of Physical Parameters in Modern Approach in State Survey at the Faculty of Geodesy of the University of Zagreb, and in front of the Commission consisting of Assoc. Prof. Dr. Željko Bačić, Prof. Dr. Tomislav Bašić (mentor, both from the Faculty of Geodesy, University of Zagreb, and Assist. Prof. Božo Soldo from the Faculty of Geotechnical Engineering Varaždin of University of Zagreb.
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International Nuclear Information System (INIS)
Bagli, S.; Pistocchi, A.; Mazzoli, P.; Valentini, P.
2006-01-01
The paper demonstrates an application of advanced decision support tools within the framework of the environmental information system of the Province of Milan. These tools include environmental simulation models, multi criteria analysis, risk analysis and environmental accounting for marketable emission permits. After describing the general structure of the system, three demonstrational case studies are introduced concerning: groundwater pollution management; atmospheric pollution management; urban environmental quality perception and management. In the conclusion, potential use of tools like the ones implemented by the province of Milan within the framework of Local Agenda 21 processes is recalled [it
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Directory of Open Access Journals (Sweden)
Giuliana Albini
2011-04-01
Full Text Available The history of charity and assistance in Milan at the end of the Middle Ages has as basic term of reference the documentary sources of the Ospedale Maggiore, the new great hospital result of a long process of reform that took place in the course of the 15th century. The Chapter of the Ospedale Maggiore became a management centre which planned and controlled the activities of other charitable-attendance structures, the most important of them represented in the corporative administrative body of the Ospedale Maggiore itself. The Ospedale Maggiore Chapter left evidence of its meetings and decisions in more than 3000 proceedings, registered in seven records. The board resolutions of the Ospedale Maggiore of Milan are a basic source for the history of hospitals of all Lombardy. Moreover, they shed light on economic, social and political dynamics of the Duchy of Milan at the end of Quattrocento: the organization of the Ospedale Maggiore board highlights on politics and strategies of the ruling groups of Milan and of the Sforza dynasty as well. Object of this work is the edition, in the form of regestum, of the Ospedale Maggiore Chapter resolutions; a map of the country estate, land, farms, mills, of the Ospedale Maggiore, is edited too.
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Cradles of industry and occupational medicine in the modern world: Milan 1906 -- Annus Mirabilis.
Baldasseroni, A; Carnevale, F; Tomassini, L
2013-01-01
The example examined is Milan, Italy's main industrial city, where the great International Exhibition was held in 1906. This was the culmination of a period of accelerated industrial growth that modern-day historiography considers to be when Italy's first real industrial revolution began. The twenty-five years between the National Industrial Exhibition of 1881, which was also held in Milan, and the 1906 Exhibition truly reflected a period which was crucial for this transformation to take of. Alongside industry, which was then going through a phase of reorganization and development, Milanese civil society was increasingly turning its interest and attention to what was called the "social question". In an atmosphere of debate and exchange of ideas and experience with Turin, another major industrial city of the north and the birthplace of the Italian engineering and automobile industries, social organizations, political parties and trade unions began to be established thus heralding the Italian approach towards twentieth-century welfare. This is the context in which the first International Congress on Occupational Diseases was held in Milan from 9 to 14 June 1906 within the framework of the International Exhibition. The success achieved with this initiative. organized by Luigi Devoto and Malachia De Cristoforis, which was to continue with the founding of the International Permanent Commission on Occupational Health, showed that the time was ripe for a new subject to appear on the scene--the occupational health physician--who from then on was to play an important role in the promotion of workers' health. The article outlines the main features of the Italian industrial transformation at the turn of the new century with special attention focused on Milan, the capital of industry in Italy. It also describes the impact on public opinion caused by the events surrounding the epic construction of the transalpine railway tunnels which began in 1856 with the Mont Cenis tunnel
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Preliminary Statistics from the NASA Alphasat Beacon Receiver in Milan, Italy
Nessel, James; Zemba, Michael; Morse, Jacquelynne; Luini, Lorenzo; Riva, Carlo
2015-01-01
NASA Glenn Research Center (GRC) and the Politecnico di Milano (POLIMI) have initiated a joint propagation campaign within the framework of the Alphasat propagation experiment to characterize rain attenuation, scintillation, and gaseous absorption effects of the atmosphere in the 40 gigahertz band. NASA GRC has developed and installed a K/Q-band (20/40 gigahertz) beacon receiver at the POLIMI campus in Milan, Italy, which receives the 20/40 gigahertz signals broadcast from the Alphasat Aldo Paraboni TDP no. 5 beacon payload. The primary goal of these measurements is to develop a physical model to improve predictions of communications systems performance within the Q-band. Herein, we provide an overview of the design and data calibration procedure, and present 6 months of preliminary statistics of the NASA propagation terminal, which has been installed and operating in Milan since May 2014. The Q-band receiver has demonstrated a dynamic range of 40 decibels at an 8-hertz sampling rate. A weather station with an optical disdrometer is also installed to characterize rain drop size distribution for correlation with physical based models.
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1997-09-01
91-D-0012 Task Order No. 0007 2.4.7 Milan Army Ammunition Plant, Phytoremediation Pilot Study, USAEC, 1996 .. .............................. 2-28 2.5...indicated that heavy metal contamination (lead, chromium, and mercury ) was present at relatively low levels, and explosive contamination was limited to...and MI172 where lead was found at 22.9 j.g/1 and 18.4 Ig/l, respectively. 2.4.7 Milan Army Ammunition Plant, Phytoremediation Pilot Study, USAEC, 1996
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Directory of Open Access Journals (Sweden)
Teng Chieh-Lin
2012-02-01
Full Text Available Abstract Background Orthotopic liver transplantation (OLT is one of the most effective treatments for patients with hepatocellular carcinoma (HCC within the Milan criteria. However, for patients beyond these criteria, the recurrence rate is higher and the prognosis is worse. Sorafenib is the only drug showing survival benefits in advanced HCC patients; however, its role in patients beyond the Milan criteria after OLT remains unclear and requires further investigation. Methods As a case-control study, we retrospectively analyzed 17 Chinese patients beyond Milan criteria undergoing OLT for HCC. These patients were stratified into adjuvant (n = 5, palliative (n = 6, and control groups (n = 6. Results Nine of 11 patients who received sorafenib after OLT needed dose reduction due to more than grade 2 side effects. The disease-free survival rates for patients with or without adjuvant sorafenib were 100% versus 37.5% (p = 0.034 at 6 months, 66.7% versus 9.4% (p = 0.026 at 12 months, and 66.7% versus 0.0% (p = 0.011 at 18 months, respectively. The overall survival rates for patients in palliative and control groups were 66.7% versus 40.0% (p = 0.248 at 6 months, 66.7% versus 40.0% (p = 0.248 at 12 months, and 50.0% versus 20.0% (p = 0.17 at 18 months, respectively. Patients in the adjuvant group had better overall survival rates than those in the palliative and control groups (p = 0.031 at 24-month follow-up. Conclusions Adjuvant sorafenib could possibly extend both disease-free and overall survival for HCC patients beyond Milan criteria after OLT.
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Satellite air temperature estimation for monitoring the canopy layer heat island of Milan
DEFF Research Database (Denmark)
Pichierri, Manuele; Bonafoni, Stefania; Biondi, Riccardo
2012-01-01
across the city center from June to September confirming that, in Milan, urban heating is not an occasional phenomenon. Furthermore, this study shows the utility of space missions to monitor the metropolis heat islands if they are able to provide nighttime observations when CLHI peaks are generally......In this work, satellite maps of the urban heat island of Milan are produced using satellite-based infrared sensor data. For this aim, we developed suitable algorithms employing satellite brightness temperatures for the direct air temperature estimation 2 m above the surface (canopy layer), showing...... 2007 and 2010 were processed. Analysis of the canopy layer heat island (CLHI) maps during summer months reveals an average heat island effect of 3–4K during nighttime (with some peaks around 5K) and a weak CLHI intensity during daytime. In addition, the satellite maps reveal a well defined island shape...
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Religious tolerance in the Edict of Milan and in the Constitution of Medina
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Đurić Drago
2013-01-01
Full Text Available In this paper, we will try to offer a blueprint for a more general discussion of the relation of how the question of religious tolerance appears in two documents that the Christian and Islamic traditions recognize and celebrate: namely, the Edict of Milan and the Constitution of Medina. These documents were revolutionary for their time. However, these documents alone, as well as religious teachings, on which they are based, cannot be the measure of relations in our time. They are presented in the conceptual framework and value system that prevailed at the time when these teachings and documents were created. Many relations the documents refer to no longer exist. For example, while the Edict of Milan affirms the general right to religion, and the Constitution of Medina affirms the mutual tolerance for Abrahamic, monotheistic religions - people who now declare themselves as atheists or agnostics are not even mentioned.
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Ärimees ootab annetuse eest Keskerakonnalt vastuteenet / Dannar Leitmaa, Erik Rand, Milan Bališ
Leitmaa, Dannar, 1982-
2009-01-01
Slovakkia ärimehed annetasid Eesti Keskerakonnale 1,4 mln. krooni, avaliku teenistuse eetikakoodeksi autor Ivar Tallo peab välismaistelt annetajatelt raha saamist taunitavaks. Annetustest teistele erakondadele I kvartalis. Vt. samas lühiintervjuud Milan Bališiga
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Construction and assembling of the trim coils for the Milan superconducting cyclotron
International Nuclear Information System (INIS)
Baccaglioni, G.; Cartegni, G.C.; Fusetti, M.; Gini, L.; Grilli, L.
1986-01-01
This paper presents the main characteristics of the trim coils realized for the heavy ions superconducting cyclotron under construction at the Milan University. The guidelines in the choice of the conductor size, of the insulation and cooling parameters are discussed in some details. The main operations in the coils construction, as winding, impregnation, electrical tests and assembling, are described
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Energy Technology Data Exchange (ETDEWEB)
Bova, Valentina; Miraglia, Roberto, E-mail: rmiraglia@ismett.edu; Maruzzelli, Luigi [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Diagnostic and Interventional Radiology (Italy); Vizzini, Giovanni Battista [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Hepatology (Italy); Luca, Angelo [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Diagnostic and Interventional Radiology (Italy)
2013-04-15
This study was designed to analyze the clinical results in patients suitable for liver transplantation with hepatocellular carcinoma (HCC) who exceeded Milan criteria, which underwent intra-arterial therapies (IAT), to determine predictive factors of successful downstaging. A total of 277 consecutive patients with cirrhosis and HCC were treated by IAT (transarterial oily chemoembolization, transarterial chemoembolization, transarterial embolization) in a single center. Eighty patients exceed the Milan criteria. Patients with infiltrative HCC, hypovascular HCC, and portal vein thrombosis were excluded, with a final study population of 48 patients. Tumor response to IAT was evaluated with CT and/or MRI according to modified RECIST criteria. Successful downstaging was defined as a reduction in the number and size of viable tumors to within the Milan criteria, and serum alpha-fetoprotein (AFP) <100 ng/mL, for at least 6 months. Nineteen patients (39 %) had their tumors successfully downstaged; 29 patients (61 %) did not. Multivariate analysis showed that AFP level <100 ng/mL and 3-year calculated survival probability using the Metroticket calculator were the only independent predictors of successful downstaging (p < 0.023 and p < 0.049 respectively). Biological characteristics of HCC as AFP levels <100 ng/mL and high 3-year calculated survival probability may predict a good response to downstage after IAT.
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Follow-up of 53 Alzheimer patients with the MODA (Milan Overall Dementia Assessment).
Capitani, E; Manzoni, L; Spinnler, H
1997-01-01
Fifty-three patients affected by Alzheimer's disease entered a longitudinal survey aimed at studying which factors influence the rate of progression, assessed by means of the Milan Overall Dementia Assessment (MODA). The second examination was carried out, on average, after 16 months from the first assessment. Only age proved to influence the decline rate, which was faster in elders.
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Malacarne, Mara; Lesma, Alessandro; Madera, Angelo; Malfatti, Eugenio; Castelli, Alberto; Lucini, Daniela; Pizzinelli, Paolo; Pagani, Massimo
2004-01-01
This paper describes preliminary experience in shared clinical management of patients located in Pointe Noire, Africa, and a referral center, Sacco University Hospital, located in Milan, Italy. The employed infrastructure INteractive TeleConsultation Network for Worldwide HealthcAre Services (INCAS) jointly developed by CEFRIEL (Center of Excellence For Research, Innovation, Education & Industrial Labs partnership) and ENI (Ente Nazionale Idrocarburi) is based on commercial off-the-shelf technology. This minimizes maintenance problems, while permitting a simple and friendly sharing of data using the telephone and e-mail for store-and-forward applications. The critical aspect of the flow of events comprising the exchange of information is discussed. In 60% of cases, only one telemedicine consultation was required. In the remainder 40%, a number of telemedicine consultations were required for appropriate management of clinical cases. The project demonstrated flexibility as documented by the wide range of pathologies that can be dealt with it. Finally the possibility of using shared clinical management as a learning tool is highlighted by the steep and rising learning curve. We conclude, however, that the patient, although handled in a "virtual" manner, should be viewed as very "real," as some of them elected to close the gap physically between Pointe Noire and Milan, and chose to be treated at the referral site.
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Directory of Open Access Journals (Sweden)
Monica Lavagna
2014-05-01
Full Text Available Politecnico di Milano University worked for the Italian Ministry of Environment, land and sea on the sustainability assessment of Expo Milan 2015 self-built temporary pavilions. The work has been focused on the improvement of the buildings environmental performances. Given the buildings short durability in place (Expo lasts for 6 months, the strategies for their end of life are of great importance for the carbon footprint reduction. Starting from the specific work on Expo Milan 2015, the Politecnico di Milano working group proceeded with the methodology research about this issue, applicable also to future events. This paper presents the different relevant aspects of mega events temporary buildings end of life management; dealing with methodological, technical and managerial aspects.
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Treatment Algorithm for the Hypertension Specialist after the Milan Meeting in 2007
Czech Academy of Sciences Publication Activity Database
Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana
2007-01-01
Roč. 30 (2007), s. 374-374 ISSN 1420-4096. [Central European Meeting on Hypertension and Cardiovascular Disease Prevention. 11.10.2007-13.10.2007, Kraków] R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : hypertension specialist * treatment algorithm for the hypertension * treatment after the Milan Meeting in 2007 Subject RIV: FA - Cardiovascular Disease s incl. Cardiotharic Surgery
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The radioactive cloud on Milan and other neighbouring sites
International Nuclear Information System (INIS)
Capra, D.; Facchini, U.; Gianelle, V.; Marcazzan, G.M.; Ravasini, G.; Carreri, V.; Gualdi, R.; Sgorbati, G.; Tebaldi, G.
1986-01-01
The radioelements spread from the nuclear disaster in Ukraina reached the Milan atmosphere the evening of April, 30. A number of measurements started on air particulate; a number of radioelements was evidenced: Iodine, Tellerium, Cesium, Ruthenium and other. Then the presence of radioelements have been found in rain, in the first days of May, and consequently in the soil. Different samples show that the level of radioactivity in the Como lake area was greater than the average levels in Lombardy by a factor 2 or 3. Direct measurements of the gamma level on the ground give more evidence to this fact. The role of the rainfalls is discussed
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National Research Council Canada - National Science Library
Kedem, Zvi
2000-01-01
The MILAN project, a joint effort involving Arizona State University and New York University, has produced and validated fundamental techniques for the realization of efficient, reliable, predictable...
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Sound quality indicators for urban places in Paris cross-validated by Milan data.
Ricciardi, Paola; Delaitre, Pauline; Lavandier, Catherine; Torchia, Francesca; Aumond, Pierre
2015-10-01
A specific smartphone application was developed to collect perceptive and acoustic data in Paris. About 3400 questionnaires were analyzed, regarding the global sound environment characterization, the perceived loudness of some emergent sources and the presence time ratio of sources that do not emerge from the background. Sound pressure level was recorded each second from the mobile phone's microphone during a 10-min period. The aim of this study is to propose indicators of urban sound quality based on linear regressions with perceptive variables. A cross validation of the quality models extracted from Paris data was carried out by conducting the same survey in Milan. The proposed sound quality general model is correlated with the real perceived sound quality (72%). Another model without visual amenity and familiarity is 58% correlated with perceived sound quality. In order to improve the sound quality indicator, a site classification was performed by Kohonen's Artificial Neural Network algorithm, and seven specific class models were developed. These specific models attribute more importance on source events and are slightly closer to the individual data than the global model. In general, the Parisian models underestimate the sound quality of Milan environments assessed by Italian people.
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Violència i memòria en Milan Kundera
Tafalla, Marta
2007-01-01
Partint de la filosofia de la memòria de TW Adorno, aquest article defensa la tesi deque la literatura té una major capacitat que la història o la filosofia per explicar Enquin consisteixen els règims totalitaris i per salvaguardar la memòria de les seves víctimes. Amb aquest propòsit, pren com a exemple la literatura de l'escriptor txec Milan Kundera yanaliza algunes de les seves obres, especialment El llibre del riure i l'oblit, La insoportablelevedad l'ésser i el seu assaig L'art de...
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Directory of Open Access Journals (Sweden)
Andrea Rolando
2014-12-01
Full Text Available This paper aims at understanding how a better relationship between infrastructures and landscapes can be established, by encouraging new ways to experience and effectively use the places that are located near the infrastructural nodes. The work starts from the identification of a specific case study: the landscape in-between the cities of Milan and Turin, that are connected by the infrastructural bundle made of the three lines of the regional / historical railways, the motorway and the new tracks of the high speed train. The research highlights cultural heritage sites and places of interest, points out a series of areas and routes that connect them with the infrastructure. The Milan 2015 Expo could in this sense be a very powerful catalyst, by encouraging these intermodal uses of the infrastructural bundle to reach and truly experience the agricultural and cultural landscapes located around it.
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Energy Technology Data Exchange (ETDEWEB)
Clini, V.; Pozzi, G.; Ferrara, A.
1985-01-01
Research has been carried out in the town area of Milan on 275 subjects. For each patient the following data have been measured: ventilatory profile, aspecific bronchial reactivity, arterial concentration in CO and acid-base balance. The results obtained have been divided into four groups, according to the level of SO/sub 2/ in the area of residence of the subjects, who have also been studied with reference to the habit of smoking. The data obtained have shown (1) an alteration of the ventilatory function, with decrease of oxygen tension in arterial blood in all subjects. (2) Increase of bronchial irritability and CO concentration in arterial blood have been found in these subjects. (3) The division of the results according to the level of SO/sub 2/ pollution in the areas of residence of the patients showed the presence, in the most polluted areas of Milan (NE and SW), of higher levels of bronchial irritability and higher CO rates in arterial blood. (4) Cigarette smoking does not seem to play a major role in causing bronchial irritability. It certainly increases CO concentration: smokers have HbCO concentration higher than nonsmokers in all four areas. (5) Air pollution is more important than cigarette smoking in determining CO saturation of blood. Nonsmokers living in the most polluted areas of Milan (NE) show a higher concentration of CO in arterial blood than smokers living in the less polluted areas (SW).
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Directory of Open Access Journals (Sweden)
Katia Razzini
2015-08-01
Full Text Available The regulatory framework of the official controls on food safety, the criteria and methods from the planning of interventions in the field of official control to the management of information flows, and the standards described in the operation manual of the local competent authorities drafted by the Lombardy Region (2011 were evaluated. A questionnaire consisting of n. 10 questions with multiple answers draft in partnership with EPAM (the Association of Provincial Public Retail and catering businesses in Milan to n. 107 Food service establishments of Milan shows that 92% of managers approve the introduction of a grading system. The regulatory framework is planned to support the implementation of risk assignment, unfortunately the attribution of risk category of retail and catering businesses is still different among regions.
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Living like a king? The entourage of Odet de Foix, vicomte de Lautrec, governor of Milan.
Directory of Open Access Journals (Sweden)
Philippa Woodcock
2015-11-01
Full Text Available In the early sixteenth century, the de Foix family were both kin and intimate councillors to the Valois kings, Louis XII and François I. With a powerbase in Guyenne, the de Foix tried to use their connections at court to profit from the French conquest of Milan, 1499-1522. This paper will explore the career of one prominent family member, Odet de Foix, vicomte de Lautrec (1483-1528. Lautrec was a Marshal of France, who served in Italy as a soldier and governor. He was key to the royal entourage, amongst François I’s intimates at the Field of the Cloth of Gold. His sister, Françoise, was also the king’s mistress. The paper will examine Lautrec’s entourage from two aspects. Firstly, it asks how Lautrec established his entourage from his experience in Navarre and Italy and as a member of the royal retinue. It establishes the importance of familial and regional ties, but also demonstrates the important role played by men of talent. Secondly, it explores Lautrec's relationship to his entourage once governor of Milan. Were ties of blood, career or positions of Italian prestige the most important for a governor when he chose his intimates? Were compromises made with Italian traditions and elites to sustain his rule? Did he learn from the experience and failures of previous governors? The article contributes to a gap in scholarship for the later period of French Milan from 1515-1522. It also adds to our knowledge of the behaviour and ambitions of early modern governors.
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Ferroli, Paolo; Broggi, Morgan; Schiavolin, Silvia; Acerbi, Francesco; Bettamio, Valentina; Caldiroli, Dario; Cusin, Alberto; La Corte, Emanuele; Leonardi, Matilde; Raggi, Alberto; Schiariti, Marco; Visintini, Sergio; Franzini, Angelo; Broggi, Giovanni
2015-12-01
OBJECT The Milan Complexity Scale-a new practical grading scale designed to estimate the risk of neurological clinical worsening after performing surgery for tumor removal-is presented. METHODS A retrospective study was conducted on all elective consecutive surgical procedures for tumor resection between January 2012 and December 2014 at the Second Division of Neurosurgery at Fondazione IRCCS Istituto Neurologico Carlo Besta of Milan. A prospective database dedicated to reporting complications and all clinical and radiological data was retrospectively reviewed. The Karnofsky Performance Scale (KPS) was used to classify each patient's health status. Complications were divided into major and minor and recorded based on etiology and required treatment. A logistic regression model was used to identify possible predictors of clinical worsening after surgery in terms of changes between the preoperative and discharge KPS scores. Statistically significant predictors were rated based on their odds ratios in order to build an ad hoc complexity scale. For each patient, a corresponding total score was calculated, and ANOVA was performed to compare the mean total scores between the improved/unchanged and worsened patients. Relative risk (RR) and chi-square statistics were employed to provide the risk of worsening after surgery for each total score. RESULTS The case series was composed of 746 patients (53.2% female; mean age 51.3 ± 17.1). The most common tumors were meningiomas (28.6%) and glioblastomas (24.1%). The mortality rate was 0.94%, the major complication rate was 9.1%, and the minor complication rate was 32.6%. Of 746 patients, 523 (70.1%) patients improved or remained unchanged, and 223 (29.9%) patients worsened. The following factors were found to be statistically significant predictors of the change in KPS scores: tumor size larger than 4 cm, cranial nerve manipulation, major brain vessel manipulation, posterior fossa location, and eloquent area involvement
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ESO Council Visits First VLT Unit Telescope Structure in Milan
1995-12-01
As the ESO Very Large Telescope (VLT) rapidly takes on shape, Europe has just come one step closer to the realisation of its 556 million DEM astronomical showcase project. Last week, the ESO Council held its semi-annual meeting in Milan (Italy) [1]. During a break in the long agenda list, Council members had the opportunity to visit the Ansaldo factory in the outskirts of this city and to see for the first time the assembled mechanical structure of one of the four 8.2-metre VLT Unit telescopes. This Press Release is accompanied by a photo that shows the ESO Council delegates in front of the giant telescope. After a long climb up the steep staircase to the large Nasmyth platform at the side of the telescope where the astronomical instruments will later be placed, Dr. Peter Creola (Switzerland) , President of the ESO Council and a mechanics expert, grabbed the handrail and surveyed the structure with a professional eye: `I knew it was going to be big, but not that enormous!', he said. Other delegates experienced similar feelings, especially when they watched the 430 tonnes of steel in the 24-metre tall and squat structure turn smoothly and silently around the vertical axis. The Chairman of the ESO Scientific Technical Committee (STC), Dr. Johannes Andersen (Denmark) , summarized his first, close encounter with the VLT by `This is great fun!' and several of his colleague astronomers were soon seen in various corners of the vast structure, engaged in elated discussions about the first scientific investigations to be done with the VLT in two years' time. The VLT Main Structures The visit by Council took place at the invitation of Ansaldo Energia S.p.A. (Genova), EIE-European Industrial Engineering S.r.I. (Venice) and SOIMI-Societa Impianti Industriale S.p.A. (Milan), the three Italian enterprises responsible for the construction of the main structures of the VLT 8.2-metre Unit telescopes. Short speeches were given on this occasion by Drs. Ferruccio Bressani (Ansaldo
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Italy on the spotlight: Expo Milan 2015 and Italian Journal of Food Science
Directory of Open Access Journals (Sweden)
P. Fantozzi
2015-12-01
Full Text Available The year 2015 will certainly be remembered as the Year of the Universal Exposition (EXPO hosted in Milan, Italy, focusing on a hot theme in the current scenario: “Feeding the Planet, Energyfor Life”.This event has drawn a wide international attention towards Italy as a country with peculiar and valuable food traditions, thus strengthening its reputation as “gastronomic capital of theworld” rich in protected designation of origin products (PDOs and characterised by a longstanding food culture.
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Directory of Open Access Journals (Sweden)
G. D’Anna
2009-09-01
Full Text Available The demand of short food supply chains is becoming more pressing by consumers, especially in the largest school catering. The implementation of the short chain in a large catering company of Milan, is described in this practical contribution. Several aspects of short food chains sustainability: legal, commercial and economic sustainability, hygienic and gastronomic sustainability, are discussed.
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Evolution of traffic emissions in European urban areas: Milan case study
International Nuclear Information System (INIS)
Giugliano, M.; Cemin, A.; Cernuschi, S.
1992-01-01
The worldwide increasing role of mobile sources on the air quality of urban areas requires a careful evaluation of all the potential intervention policies for the reduction of traffic related emissions. The accurate description of the evolution of the source, following the renewal of the fleet with vehicles regulated by stricter emission standards, represents the basic premise for this evaluation. This paper outlines a proposed methodology for the evaluation of the trend of mobile source emissions, implemented on the calculation program EMISMOB, and reports the results obtained with its application to predict the evolution of traffic emissions in the urban area of Milan (Italy) until the year 2010
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Pollution by lead near the Turin--Milan highway
Energy Technology Data Exchange (ETDEWEB)
Sapetti, C; Arduino, E
1973-10-01
Soil samples taken at 5 to 50 m from the Turin-Milan highway at depths ranging from 0 to 30 cm on two different sites were analyzed for lead residues by atomic absorption spectrophotometry following extraction by means of ammoniacal EDTA at pH 9. Soil samples from the surface layer taken in one well-ventilated site contained 11.5 to 12.4 ppM lead, while subsoil samples had 5.7 to 9.8 ppM. Soil samples taken in the other site with poor ventilation contained 23.5 to 43.3 ppM lead in the surface layer, and 9.2 to 15.4 ppM in the subsoil. Decrease of the lead concentrations in the soil with increasing depth and distance from the highway was noted. Plant samples taken from the same sites contained 6.4 to 32.2 ppM lead. Lead was fixed predominantly to the exchange complex; partly to the clay fraction, and partly to the humic fraction.
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Binder characterisation of mortars used at different ages in the San Lorenzo church in Milan
International Nuclear Information System (INIS)
Bertolini, Luca; Carsana, Maddalena; Gastaldi, Matteo; Lollini, Federica; Redaelli, Elena
2013-01-01
The paper describes a study on the mortars of the basilica of San Lorenzo in Milan, which was carried out to support an archaeological study aimed at dating and documenting the construction techniques used throughout the centuries. The church, which was founded between the 4th and 5th century, at the end of the period when Milan was the capital of the Roman Empire, was subjected in time to extensions, collapses and reconstructions that lasted until the Renaissance period and even later on. Thanks to the good state of conservation, San Lorenzo church is a collection of materials and construction techniques throughout a period of more than a millennium. Mortars were investigated in order to compare the binders used for structural elements built in different historical ages. From an archaeological study, samples of mortars attributed to the late Roman period, the Middle Ages and the Renaissance were available. The binder of each sample was separated by the aggregates and it was characterised on the basis of X-ray diffraction analysis, thermogravimetric analysis and scanning electron microscopy. Constituents of the binder were identified and their origin is discussed in order to investigate if they could be attributed to the original composition of the binder or to possible alteration in time due to atmospheric pollution. Results show that, even though the binder is mainly based on magnesian lime, there are significant differences in the microstructure of the binding matrix used in mortars ascribed to the different historical periods. In the Roman period, in correspondence of the structural elements that required higher strength, also hydraulic cocciopesto mortars were detected. Gypsum was found in most samples, which was maybe added intentionally. - Highlights: • Binders of mortars of San Lorenzo church in Milan were investigated. • Roman, Middle Ages and Renaissance samples were studied by XRD, TG and SEM. • Magnesian-lime binders containing silico
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Seror, Olivier; N'Kontchou, Gisèle; Nault, Jean-Charles; Rabahi, Yacine; Nahon, Pierre; Ganne-Carrié, Nathalie; Grando, Véronique; Zentar, Nora; Beaugrand, Michel; Trinchet, Jean-Claude; Diallo, Abou; Sellier, Nicolas
2016-08-01
Purpose To assess the long-term outcome in 108 consecutive patients treated with no-touch multibipolar radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) that met the Milan criteria. Materials and Methods This retrospective study was approved by the ethical review board, and the need to obtain informed consent was waived. Between November 1, 2006, and December 31, 2011, 132 HCC tumors (diameter, 10-45 mm; 39 tumors ≥ 30 mm) in 108 consecutive patients (106 with cirrhosis) that met Milan criteria were treated with no-touch multibipolar RFA, which consisted of activating, in bipolar mode, three or four electrodes inserted just beyond the tumor margins. Follow-up was performed every 3 months for 2 years and every 6 months thereafter with computed tomographic or magnetic resonance imaging. Survival probabilities were computed by using the Kaplan-Meier method. Predictive factors of tumor progression and overall survival were assessed by using the Cox proportional hazard model. Results No technical failure occurred, and complete ablation was achieved for all the nodules. After a median of 40.5 months (range, 2-84 months) of follow-up, 3- and 5-year local and overall tumor progression-free survival were 96%, 94%, 52%, and 32%, respectively. Neither tumor diameter greater than 30 mm nor location abutting a large vessel were associated with local tumor progression. Tumor diameter greater than 30 mm was the only parameter predictive of overall tumor progression (P = .0036). Independent factors associated with shorter overall survival were Child-Pugh class B disease, age greater than 65 years, and platelet count of less than 150 g/L (P touch multibipolar RFA for HCC tumors that meet Milan criteria provides a high local tumor progression-free survival rate. An ongoing randomized trial might help to clarify the role of this new approach for the treatment of early HCC. (©) RSNA, 2016 Online supplemental material is available for this article. An earlier
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Long-lived 222Rn progeny concentrations in ground level air of Milan
International Nuclear Information System (INIS)
Marcazzan, G.M.; Valli, G.; Vecchi, R.; Bocelli, R.
2002-01-01
Short-lived (2 18P o, 2 14P b, 2 14B i, 2 14P o) as well as long-lived (2 10P b, 2 10B i, 2 10P o) Radon's decay products in atmosphere are due to the 2 22R n exhalation from the continental Earth's crust, where it is generated in the 2 38U decay series. The measurement of the radionuclides concentration in the atmosphere - in addition to yielding valuable data for radioprotection purposes and for assessing the environmental impact of natural radioactivity - can provide information on atmospheric thermodynamic conditions as well as on atmospheric processes that involve aerosols such as transport, dispersion, removal rates and residence time. In particular, the concentration ratio of 2 10P b with other Radon's daughters can be used to obtain information on mean residence time of aerosols (Poet et al., 1972; Rangarajan, 1992; Gaggeler et al., 1995). Continuous measurements of hourly concentration of Radon and its short-lived progeny are routinely carried out in Milan by our group, and the temporal behaviour comes out a suitable tracer of atmospheric stability conditions and a local index of the evolution of the mixing layer height (Marcazzan et al., 1993; Marcazzan et al., 1997). The aim of this work was to measure the concentration and temporal behaviour of 2 10P b on a weekly and a monthly scale at ground level in the urban area of Milan and to get reliable measurements on the annual average concentration for the implementation of the existing data base (Preiss et al., 1996)
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Preliminary design of the beam transport system for the Milan biomedical cyclotron
International Nuclear Information System (INIS)
Silari, M.
1988-01-01
This report illustrates the preliminary design of the beam transport system for the Scanditronix MC40 cyclotron to be installed in Milan. The Cyclotron will be dedicated to biomedical research and the different experimental conditions that could occur will require a beam transport system flexible enough so as to deliver beams with the specified characteristics. The report describes the computer codes used, the calculations performed and the results obtained. The complete configuration of the beam lines serving the first two target rooms is given, together with typical beam profiles and the emittance ellipse variation along the transfer channels
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Santus Pierachille; Russo Antonio; Madonini Enzo; Allegra Luigi; Blasi Francesco; Centanni Stefano; Miadonna Antonio; Schiraldi Gianfranco; Amaducci Sandro
2012-01-01
Abstract Background Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy. Methods We collected data from 45770 ERAs for respiratory diseases. A time-stratified case-crossover design was used to investigate the association bet...
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Amendola, Antonella; Bianchi, Silvia; Frati, Elena R; Ciceri, Giulia; Faccini, Marino; Senatore, Sabrina; Colzani, Daniela; Lamberti, Anna; Baggieri, Melissa; Cereda, Danilo; Gramegna, Maria; Nicoletti, Loredana; Magurano, Fabio; Tanzi, Elisabetta
2017-08-17
A large measles outbreak has been ongoing in Milan and surrounding areas. From 1 March to 30 June 2017, 203 measles cases were laboratory-confirmed (108 sporadic cases and 95 related to 47 clusters). Phylogenetic analysis revealed the co-circulation of two different genotypes, D8 and B3. Both genotypes caused nosocomial clusters in two hospitals. The rapid analysis of epidemiological and phylogenetic data allowed effective surveillance and tracking of transmission pathways. This article is copyright of The Authors, 2017.
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Directory of Open Access Journals (Sweden)
Magni MC
2015-08-01
Full Text Available Maria Chiara Magni,1 Laura Veneroni,1 Carlo Alfredo Clerici,2 Tullio Proserpio,3 Giovanna Sironi,1 Michela Casanova,1 Stefano Chiaravalli,1 Maura Massimino,1 Andrea Ferrari1 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 3Pastoral Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Abstract: Adolescence is a particularly complex time of life, entailing physiological, psychological, and social changes that further the individual's cognitive, emotional, and social growth. Being diagnosed with cancer at this time can have important consequences on an individual's emotional and physical development, and adolescent and young adult cancer patients have particular medical and psychosocial needs. Patient–physician communications are important in any clinical relationship, but fundamental in the oncological sphere because their quality can affect the patient–physician relationship, the therapeutic alliance, and patient compliance. A major challenge when dealing with adolescent and young adult patients lies in striking the right balance between their need and right to understand their disease, treatment, and prognosis, and the need for them to remain hopeful and to protect their emotional sensitivity. We herein describe the activities of the Youth Project of the Istituto Nazionale Tumori in Milan, Italy in order to share a possible model of interaction with these special patients and the tactics our group has identified to help them communicate and share their thoughts. This model implies not only the involvement of a multidisciplinary team, including psychologists and spirituality experts, but also the constitution of dedicated creative activities to give patients the opportunity to express feelings they would otherwise never feel at ease putting into words. These efforts seek the goal to minimize the potentially
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Czech Academy of Sciences Publication Activity Database
Hladký, Ladislav; Škerlová, Jana; Cibulka, Pavel
2016-01-01
Roč. 102, č. 3 (2016), s. 393-422 ISSN 0037-6922 Institutional support: RVO:67985963 Keywords : T. G. Masaryk * South Slavs * correspondence * Milan Pribićević * Czech-South Slavs relations Subject RIV: AB - History
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Cappitelli, Francesca; Nosanchuk, Joshua D.; Casadevall, Arturo; Toniolo, Lucia; Brusetti, Lorenzo; Florio, Sofia; Principi, Pamela; Borin, Sara; Sorlini, Claudia
2007-01-01
Monuments and artistic stone surfaces are often consolidated and protected with synthetic polymers, in particular, acrylics. Although it is generally thought that acrylic polymers are resistant to biodeterioration, we report for the first time the systematic occurrence of dematiaceous meristematic fungi on many marble samples of the cathedral in Milan (Italy) previously treated with this material. Fourier transform infrared spectroscopy applied to the Milan cathedral stone samples revealed characteristic features of biodeteriorated synthetic resins that differentiated them from the aged but nonbiodeteriorated samples. Samples showing biological colonization were analyzed for the presence of fungi. Cultivation and morphological characterization and methods independent from cultivation, such as denaturing gradient gel electrophoresis coupled with partial 18S rRNA gene sequencing and immunofluorescence staining with melanin-binding antibodies, showed that melanin-producing species are heavily present on stone surfaces protected with acrylic resins. This observation raises the question of the effectiveness of acrylics in protecting stone artworks. PMID:17071788
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Cappitelli, Francesca; Nosanchuk, Joshua D; Casadevall, Arturo; Toniolo, Lucia; Brusetti, Lorenzo; Florio, Sofia; Principi, Pamela; Borin, Sara; Sorlini, Claudia
2007-01-01
Monuments and artistic stone surfaces are often consolidated and protected with synthetic polymers, in particular, acrylics. Although it is generally thought that acrylic polymers are resistant to biodeterioration, we report for the first time the systematic occurrence of dematiaceous meristematic fungi on many marble samples of the cathedral in Milan (Italy) previously treated with this material. Fourier transform infrared spectroscopy applied to the Milan cathedral stone samples revealed characteristic features of biodeteriorated synthetic resins that differentiated them from the aged but nonbiodeteriorated samples. Samples showing biological colonization were analyzed for the presence of fungi. Cultivation and morphological characterization and methods independent from cultivation, such as denaturing gradient gel electrophoresis coupled with partial 18S rRNA gene sequencing and immunofluorescence staining with melanin-binding antibodies, showed that melanin-producing species are heavily present on stone surfaces protected with acrylic resins. This observation raises the question of the effectiveness of acrylics in protecting stone artworks.
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Stones used in Milan architecture
Directory of Open Access Journals (Sweden)
Folli, Luisa
2008-06-01
Full Text Available The city of Milan lies in a plain with clayey soil well suited to brick-making, but no stone deposits. An ample supply of stone is available, however, in the surrounding hills and mountains, which are connected to the city via both natural and artificial waterways. The types of stone used since Roman times include: granite, marble and gneiss from Ossola Valley; dolomite from Lake Maggiore; detrital limestone from Ceresio Valley; sandstone from the Brianza Hills; black limestone and marble from Lake Como; and conglomerate and sandstone from the Adda River basin. Traditionally, the chief uses have been dimension stone (all stones, column shafts (granite, slabs (marble, moulding (dolomite, limestone and ornamental (marble, dolomite, limestone.La ciudad de Milán se encuentra en una llanura de suelo arcilloso adecuado para la fabricación de ladrillos pero en la cual no hay yacimientos de rocas. No obstante, en las colinas y montañas circundantes, que están comunicadas con la ciudad mediante vías navegables naturales y artificiales, sí existe una abundante cantidad de piedra. Entre los tipos de piedra utilizados desde la época de los romanos se encuentran granitos, mármoles y gneises del valle de Ossola, dolomías del lago Mayor, calizas detríticas del valle de Ceresio (Lugano, areniscas de las colinas de la Brianza, calizas negras y mármoles del lago Como y conglomerados y areniscas de la cuenca del río Adda. Tradicionalmente, los principales usos han sido la piedra de fábrica (todas ellas, fustes de columnas (granito, losas (mármol, molduras (dolomía, caliza y ornamental (mármol, dolomía, caliza.
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Directory of Open Access Journals (Sweden)
Lenka Žehrová
2015-12-01
Full Text Available Franz Kafka is undoubtebly an important part of the literary canon of the Central Europe and especially of the canon formed by Milan Kundera in his works. Kundera considers Kafka to be one of his principal masters. He sees Kafka as an antecendent of surrealism and existencialism. According to his collection of essays The Art of the Novel, Kafka is the prototype of the ideal author who invites us to cross the border of the probable showing us the world from the other side. Thus, we can observe the human existence in different and better way. By showing this, he fills up the main task of every novelist. The contribution will analyze the alludes of Kafka in the work of Kundera and will try to describe their character and explain how Kundera works with examples of Kafka and his work in his own books.
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Integrating Laser Scanner and Bim for Conservation and Reuse: "the Lyric Theatre of Milan"
Utica, G.; Pinti, L.; Guzzoni, L.; Bonelli, S.; Brizzolari, A.
2017-12-01
The paper underlines the importance to apply a methodology that integrates the Building Information Modeling (BIM), Work Breakdown Structure (WBS) and the Laser Scanner tool in conservation and reuse projects. As it is known, the laser scanner technology provides a survey of the building object which is more accurate rather than that carried out using traditional methodologies. Today most existing buildings present their attributes in a dispersed way, stored and collected in paper documents, in sheets of equipment information, in file folders of maintenance records. In some cases, it is difficult to find updated technical documentation and the research of reliable data can be a cost and time-consuming process. Therefore, this new survey technology, embedded with BIM systems represents a valid tool to obtain a coherent picture of the building state. The following case consists in the conservation and reuse project of Milan Lyric Theatre, started in 2013 from the collaboration between the Milan Polytechnic and the Municipality. This project first attempts to integrate these new techniques which are already professional standards in many other countries such as the US, Norway, Finland, England and so on. Concerning the methodology, the choice has been to use BIM software for the structured analysis of the project, with the aim to define a single code of communication to develop a coherent documentation according to rules in a consistent manner and in tight schedules. This process provides the definition of an effective and efficient operating method that can be applied to other projects.
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International Nuclear Information System (INIS)
Cappitelli, Francesca; Principi, Pamela; Pedrazzani, Roberta; Toniolo, Lucia; Sorlini, Claudia
2007-01-01
Surfaces are continuously exposed to physical, chemical and biological degradation. Among the biological agents that cause deterioration, microorganisms are of critical importance. This work is part of a research programme for the characterisation of the alterations of the Milan Cathedral (Italy). Four stone samples of the Milan Cathedral were chemically analysed and the microbiological growth assessed. X-ray diffraction (XRD) showed that calcite was always present in each sample and one sample was also characterised by the chemical form of alteration gypsum. Using Fourier Transform Infrared Spectroscopy (FTIR) together with Scanning Electron Microscopy (SEM), it was possible to prove that the samples were consolidated with the synthetic acrylics and epoxy resins. The green-black biological patinas of the specimens were studied using cultivation, microscope observations and a method for single-cell detection. Sampling for fluorescent in-situ hybridisation (FISH), with ribosomal RNA targeted oligonucleotide probes, was also performed using adhesive tapes. The bulk of the prokaryotes were Bacteria but some Archaea were also found. The bacterial cells were further characterised using specific probes for Cyanobacteria, and α-, β-and γ-Proteobacteria. In addition, black fungi isolated from the stone and the fungi of the standard ASTM G21-96(2002) method were employed to test if the detected synthetic resins could be used as the sole source of carbon and energy. One isolated Cladosporium sp. attacked the freshly dried acrylic resin. Results show that the detected bacteria and fungi can cause severe damage both to the stone monument and its synthetic consolidants
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Cappitelli, Francesca; Principi, Pamela; Pedrazzani, Roberta; Toniolo, Lucia; Sorlini, Claudia
2007-10-15
Surfaces are continuously exposed to physical, chemical and biological degradation. Among the biological agents that cause deterioration, microorganisms are of critical importance. This work is part of a research programme for the characterisation of the alterations of the Milan Cathedral (Italy). Four stone samples of the Milan Cathedral were chemically analysed and the microbiological growth assessed. X-ray diffraction (XRD) showed that calcite was always present in each sample and one sample was also characterised by the chemical form of alteration gypsum. Using Fourier Transform Infrared Spectroscopy (FTIR) together with Scanning Electron Microscopy (SEM), it was possible to prove that the samples were consolidated with the synthetic acrylics and epoxy resins. The green-black biological patinas of the specimens were studied using cultivation, microscope observations and a method for single-cell detection. Sampling for fluorescent in-situ hybridisation (FISH), with ribosomal RNA targeted oligonucleotide probes, was also performed using adhesive tapes. The bulk of the prokaryotes were Bacteria but some Archaea were also found. The bacterial cells were further characterised using specific probes for Cyanobacteria, and alpha-, beta-and gamma-Proteobacteria. In addition, black fungi isolated from the stone and the fungi of the standard ASTM G21-96(2002) method were employed to test if the detected synthetic resins could be used as the sole source of carbon and energy. One isolated Cladosporium sp. attacked the freshly dried acrylic resin. Results show that the detected bacteria and fungi can cause severe damage both to the stone monument and its synthetic consolidants.
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Energy Technology Data Exchange (ETDEWEB)
Cappitelli, Francesca [Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, University of Milan, Via Celoria 2, 20133 Milan (Italy)], E-mail: francesca.cappitelli@unimi.it; Principi, Pamela [Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, University of Milan, Via Celoria 2, 20133 Milan (Italy); Pedrazzani, Roberta [Dipartimento di Ingegneria Meccanica, University of Brescia, Via Branze 38, 25123 Brescia (Italy); Toniolo, Lucia [Dipartimento di Chimica, Materiali e Ingegneria Chimica ' Giulio Natta' , Politecnico di Milano, Via Mancinelli 7, 20133 Milan (Italy); Sorlini, Claudia [Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, University of Milan, Via Celoria 2, 20133 Milan (Italy)
2007-10-15
Surfaces are continuously exposed to physical, chemical and biological degradation. Among the biological agents that cause deterioration, microorganisms are of critical importance. This work is part of a research programme for the characterisation of the alterations of the Milan Cathedral (Italy). Four stone samples of the Milan Cathedral were chemically analysed and the microbiological growth assessed. X-ray diffraction (XRD) showed that calcite was always present in each sample and one sample was also characterised by the chemical form of alteration gypsum. Using Fourier Transform Infrared Spectroscopy (FTIR) together with Scanning Electron Microscopy (SEM), it was possible to prove that the samples were consolidated with the synthetic acrylics and epoxy resins. The green-black biological patinas of the specimens were studied using cultivation, microscope observations and a method for single-cell detection. Sampling for fluorescent in-situ hybridisation (FISH), with ribosomal RNA targeted oligonucleotide probes, was also performed using adhesive tapes. The bulk of the prokaryotes were Bacteria but some Archaea were also found. The bacterial cells were further characterised using specific probes for Cyanobacteria, and {alpha}-, {beta}-and {gamma}-Proteobacteria. In addition, black fungi isolated from the stone and the fungi of the standard ASTM G21-96(2002) method were employed to test if the detected synthetic resins could be used as the sole source of carbon and energy. One isolated Cladosporium sp. attacked the freshly dried acrylic resin. Results show that the detected bacteria and fungi can cause severe damage both to the stone monument and its synthetic consolidants.
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National Research Council Canada - National Science Library
Best, Elly
1998-01-01
The present study was performed to elucidate the environmental behavior and fate of TNT and RDX in aquatic and wetland plants collected from a field-scale wetland demonstration deployed at Milan Army...
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D'Orso, M I; Giuliani, C; Assini, R; Riva, M A; Cesana, G
2012-01-01
Our research describes activities of Occupational Health carried out during last year in University of Milan Bicocca by Occupational Doctors. We describe results of medical surveillance in 1153 employees or students exposed to occupational risks for health and safety. We report results obtained, technical difficulties, organizational problems, and preventive actions decided to improve functionality of our activity. Students seem to be less protected and consequently seem to have higher professional safety and health risks.
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Tereanu, Carmen; Bettega, Silvia; Regalia, Enrico; Mazza, Roberto; Greco, Margherita; Lozza, Laura; Saita, Luigi; Borreani, Claudia; Quattrocolo, Alberto
2014-01-01
The "Fondazione IRCCS Istituto Nazionale dei Tumori" ( National Tumour Institute) in Milan (Italy) offers mediation services aimed at restoring communication between patients and healthcare professionals, when their relationship has been altered by a conflict during the diagnosis or treatment process. A method derived from transformative mediation is used. The purpose of mediation is not to examine clinical aspects, nor to identify who is right and who is wrong. Individual sessions are often sufficient to reduce litigation.
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The area of "Porta Vittoria” in Milan L'area “Porta Vittoria” a Milano
Directory of Open Access Journals (Sweden)
Fulvia Pinto
2011-02-01
Full Text Available The transformation of Milan, to be realized completely, needs of transport infrastructure as well as major European cities. The Rail “Passante” is a trasport infrastructure almost entirely underground and it crosses the city of Milan from north-west to south-east. The "Passante" represents the structure on which to build the urban development of the "Greater Milan" and plays a strategic role in the choice of location, facilitating the creation of an urban system integrated and competitive. The "Passante" connects the central parts of the city with suburbs that are already taking advantage of the presence of the infrastructure to renew their image. The study area was originally occupied by a station of the State Railways, now is a new station of the railway "Passante". The context of urban transformation "Porta Vittoria" is located in a central area of Milan, just beyond the first “circumvallazione”, on the connecting axis the airport of Linate. The strategic location of the area, very accessible, has determined the choice of the functions that must be kept. The regeneration is characterized by two important projects, one public and one private. The public intervention concerns the BEIC - European Library of Information and Culture, the private action relates to the new district "Porta Vittoria", with mixed-use residences, offices, malls, hotels and cinemas. The project for the European Library of Information and Culture, developed many years ago, intended to give Milan an "infrastructure" for culture considered the largest of Europe. The lack of funding has led to long interruptions and long delays in implementation. The project pays particular attention to the sustainability of the building, using energy energy-efficient systems with heat pumps (with exploiting groundwater, rather superficial in that area, solar collectors and photovoltaic panels. The hypothesis expresses the desire to create a relationship between the winning project
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Amadasi, Alberto; Boracchi, Michele; Gentile, Guendalina; Maciocco, Francesca; Maghin, Francesca; Zoja, Riccardo
2018-01-01
Self-incineration is one of the most dramatic and lethal suicide methods. It is rarely reported in Western countries and is more frequent in developing regions. We illustrate the forensic cases of self-immolation occurring over 24 years in the city of Milan, Italy, highlighting the main issues of such a complex and rare suicide. We selected 33 cases of self-incineration among 23,417 autopsies (4022 suicides) performed at the Department of Legal Medicine of the University of Milan over a period of 24 years (1993-2016). Several parameters were included and analysed: gender and age of the victims, pathological history, previous suicide intentions/attempts, duration of burning, place of death or discovery of the corpse, circumstantial data of fatal events and autopsy findings, with particular attention to thermal injuries. Self-incineration was found in 0.8% of total suicides and 0.14% of total autopsies. One of these cases involved a complex modality (association with plastic-bag suffocation). The typical characteristics of the victim were an Italian man with psychiatric illness, frequently moved by passion, existential discomfort and economic problems. During the 24-year period, the number of cases of self-incineration progressively reduced. This study provides a general overview in one of the biggest metropolitan Italian areas and is one of the few works performed on this topic. It may be helpful in understanding and studying such an unusual manner of suicide.
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Values of HbCO in 1000 inhabitants of Milan non exposed to occupational absorption of CO
Energy Technology Data Exchange (ETDEWEB)
Grisler, R.; Gobbi, A.; Giavardi, C.; Caimmi, G.; Soverini, R.; Botta, A.
1975-01-01
Carboxyhemoglobin levels for 1000 non-occupationally exposed inhabitants of Milan were determined. The study group consisted of smokers and non-smokers; among the former, only individuals refraining from smoking for at least 10 hr were tested. The upper limit of the normal range for HbCO values among non-smokers was 2.85%, while among heavy smokers it was 4.59%. Heavy smokers also showed higher HbCO levels than did moderate smokers. Elevated HbCO values were also observed among residents living in carbon monoxide-polluted urban areas as compared with those living in unpolluted rural areas.
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International Nuclear Information System (INIS)
De Martinis, C.; Ferrari, A.
1987-01-01
The electrostatic deflectors for the extraction of the beam from the Milan Superconducting Cyclotron are presently under development. The early tests showed that major troubles arise from the modifications induced in the discharge mechanism by the presence of the magnetic field, resulting in a drastic reduction of the deflector performances. Therefore a detailed analysis of the electric field configuration of the deflector has been carried out in order to improve its performances. In this paper the results so far obtained in the optimization of the shape of the electrode and insulator fixing are reported
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Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study
DEFF Research Database (Denmark)
Ogliari, Giulia; Westendorp, Rudi G J; Muller, Majon
2015-01-01
BACKGROUND: optimal blood pressure targets in older adults are controversial. OBJECTIVE: to investigate whether the relation of blood pressure with mortality in older adults varies by age, functional and cognitive status. DESIGN: longitudinal geriatric outpatient cohort. SETTING: Milan Geriatrics...... 75+ Cohort Study. SUBJECTS: one thousand five hundred and eighty-seven outpatients aged 75 years and over. METHODS: the relations of systolic (SBP) and diastolic blood pressure (DBP) with mortality risk were analysed using Cox proportional hazards models. Blood pressure, Mini-Mental State Examination......: the correlations of SBP and DBP with mortality were U-shaped. Higher SBP is related to lower mortality in subjects with impaired ADL and MMSE. ADL and MMSE may identify older subjects who benefit from higher blood pressure....
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Hong, Geun; Suh, Kyung-Suk; Suh, Suk-Won; Yoo, Tae; Kim, Hyeyoung; Park, Min-Su; Choi, YoungRok; Paeng, Jin Chul; Yi, Nam-Joon; Lee, Kwang-Woong
2016-04-01
Given the organ shortage for liver transplantation (LT) and the limitations of the current morphology-based selection criteria, improved criteria are needed to achieve the maximum benefit of LT for hepatocellular carcinoma (HCC). We hypothesized that a combination of biological markers may better predict the prognosis than the Milan criteria. HCC patients (n=123) with preoperative data on serum alpha-fetoprotein (AFP) levels and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) positivity underwent live-donor LT between January 2003 and December 2009. The cut-off values for serum AFP levels (200 ng/ml) and (18)F-FDG PET positivity (1.10) for tumor recurrence were determined by c-statistics using receiver operating characteristic curves. Univariate and multivariate analyses with preoperative variables were performed to find pre-transplant prognostic factors. Disease-free survival rates and overall survival rates were analysed with regard to serum AFP levels and (18)F-FDG PET positivity. The 5-year disease-free survival rates and overall survival rates were 80.3% and 81.6% respectively. (18)F-FDG PET positivity (hazard ratio (HR) 9.766, 95% CI 3.557-26.816; p<0.001) and serum AFP level (HR 6.234, 95% CI 2.643-14.707; p<0.001) were the only significant pre-transplant prognostic factors in the multivariate analysis; tumor number and size were not significant. A combination of criteria showed that the biologically high-risk group (AFP level ⩾200 ng/ml and PET-positive) had an HR of 29.069 (95% CI 8.797-96.053; p<0.001) compared with the double-negative group. Use of the Milan criteria yielded an HR of 1.351 (95% CI 0.500-3.652; p=0.553). The combination of the serum AFP level and (18)F-FDG PET data predicted better outcomes than those using the Milan criteria, improving objectivity when adult-to-adult living donor LT is contemplated. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.
Segré, C
2010-01-01
The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19-21 May 2010 http://www.semm.it/events_researchPast.phpThe Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe.THE CORE PARTICIPANTING INSTITUTES INCLUDED: European School of Molecular Medicine (SEMM)-IFOM-IEO Campus, MilanBeatson Institute for Cancer Research (BICR), GlasgowCambridge Research Institute (CRI), Cambridge, UKMRC Gray Institute of Radiation Biology (GIROB), OxfordLondon Research Institute (LRI), LondonPaterson Institute for Cancer Research (PICR), ManchesterThe Netherlands Cancer Institute (NKI), Amsterdam'You organizers have crushed all my prejudices towards Italians. Congratulations, I enjoyed the conference immensely!' Even if it might have sounded like rudeness for sure this was supposed to be a genuine compliment (at least, that's how we took it), also considering that it was told by a guy who himself was the fusion of two usually antithetical concepts: fashion style and English nationality.The year 2010 has marked an important event for Italian research in the international scientific panorama: the European School of Molecular Medicine (SEMM) had the honour to host the 4th International PhD Student Cancer Conference, which was held from 19-21 May 2010 at the IFOM-IEO-Campus (http://www.semm.it/events_researchPast.php) in Milan.The conference was attended by more than one hundred students, coming from a selection of cutting edge European institutes devoted to cancer research. The rationale behind it is the promotion of cooperation among young scientists across Europe to debate about science and to exchange ideas and experiences. But that is not all, it is also designed for PhD students to get in touch
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Choy, George; Rubinstein, Justin L.; Yeck, William; McNamara, Daniel E.; Mueller, Charles; Boyd, Oliver
2016-01-01
The largest recorded earthquake in Kansas occurred northeast of Milan on 12 November 2014 (Mw 4.9) in a region previously devoid of significant seismic activity. Applying multistation processing to data from local stations, we are able to detail the rupture process and rupture geometry of the mainshock, identify the causative fault plane, and delineate the expansion and extent of the subsequent seismic activity. The earthquake followed rapid increases of fluid injection by multiple wastewater injection wells in the vicinity of the fault. The source parameters and behavior of the Milan earthquake and foreshock–aftershock sequence are similar to characteristics of other earthquakes induced by wastewater injection into permeable formations overlying crystalline basement. This earthquake also provides an opportunity to test the empirical relation that uses felt area to estimate moment magnitude for historical earthquakes for Kansas.
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Linde, Cristina I.; Karashima, Eiji; Raina, Hema; Zulian, Alessandra; Wier, Withrow G.; Hamlyn, John M.; Ferrari, Patrizia; Blaustein, Mordecai P.
2012-01-01
The Milan hypertensive strain (MHS) rats are a genetic model of hypertension with adducin gene polymorphisms linked to enhanced renal tubular Na+ reabsorption. Recently we demonstrated that Ca2+ signaling is augmented in freshly isolated mesenteric artery myocytes from MHS rats. This is associated with greatly enhanced expression of Na+/Ca2+ exchanger-1 (NCX1), C-type transient receptor potential (TRPC6) protein, and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) compared with arteries from Milan normotensive strain (MNS) rats. Here, we test the hypothesis that the enhanced Ca2+ signaling in MHS arterial smooth muscle is directly reflected in augmented vasoconstriction [myogenic and phenylephrine (PE)-evoked responses] in isolated mesenteric small arteries. Systolic blood pressure was higher in MHS (145 ± 1 mmHg) than in MNS (112 ± 1 mmHg; P arteries from MHS rats had significantly augmented myogenic tone and reactivity and enhanced constriction to low-dose (1–100 nM) PE. Isolated MHS arterial myocytes exhibited approximately twofold increased peak Ca2+ signals in response to 5 μM PE or ATP in the absence and presence of extracellular Ca2+. These augmented responses are consistent with increased vasoconstrictor-evoked sarcoplasmic reticulum (SR) Ca2+ release and increased Ca2+ entry, respectively. The increased SR Ca2+ release correlates with a doubling of inositol 1,4,5-trisphosphate receptor type 1 and tripling of SERCA2 expression. Pressurized MHS arteries also exhibited a ∼70% increase in 100 nM ouabain-induced vasoconstriction compared with MNS arteries. These functional alterations reveal that, in a genetic model of hypertension linked to renal dysfunction, multiple mechanisms within the arterial myocytes contribute to enhanced Ca2+ signaling and myogenic and vasoconstrictor-induced arterial constriction. MHS rats have elevated plasma levels of endogenous ouabain, which may initiate the protein upregulation and enhanced Ca2+ signaling. These
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International Nuclear Information System (INIS)
Cesareo, R.; Marabelli, M.; Bandera, S.; Fiorini, C.; Gatti, E.; Leutenegger, P.; Longoni, A.; Gigante, G.E.
1999-01-01
The golden altar of S. Ambrogio in Milan is considered one of the most important goldsmith's work never realized. It was constructed in the period between 824 and 859 A.C. approximately. From the metallurgical point of view, ancient gold is composed, besides gold, of silver, copper, iron (< 1%), lead (< 1%) and in some cases of platinum, at trace level. Ancient silver is usually composed by copper, lead, gold (<1%) and iron (< 1%) and in some cases tin, nickel and zinc (at level of traces). The golden altar of S. Ambrogio in Milan was analyzed by means of a portable apparatus using an EDXRF-spectrometer composed by: a) the measuring head composed of a small low-power X-ray tube with a W-anode and working at 30 kV and 0.1 mA, and a thermometrically cooled small size Si-PIN X-ray detector; b) two small boxes for the bias of X-ray tube and detector respectively; c) a multi channel analyzer. For an EDXRF-analysis the measuring head simply touches the surface to be analyzed (approximately 1 cm2 ). The altar of Volvinius was analyzed in about 200 areas; some of them were analyzed twice and at different times, in order to verify the reliability of the apparatus. The four panels of the altar were then analyzed in more than 150 points, in two different sets of measurements. Standard samples were first analyzed, in order to verify the correlation between counts and concentration. Values obtained from the measurements are well comparable with standard values, within the experimental errors. This work was partially supported by the Progetto finalizzato Beni Culturali of the Consiglio Nazionale delle Ricerche
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Hitt, William D.; And Others
Existing education and training (E&T) programs at the Terre Haute Penitentiary, Indiana, and the Milan Federal Correctional Institution, Michigan, were described and evaluated. Needs, objectives, inmate classification and placement, staff, and other aspects were covered. Reports, staff and inmate interviews, study of instructional materials, and…
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MOBILE APPLICATIONS AS TOOL FOR EXPLOITING CULTURAL HERITAGE IN THE REGION OF TURIN AND MILAN
Directory of Open Access Journals (Sweden)
A. Rolando
2013-07-01
, analysis and visualization of data flows. In the current research, the field of investigation refers both to the territorial scale of Turin – Milan axis, and to the local scale of small cities localized in the territories in between. The research has been applied to Turin – Milan infrastructural axis, with the aim to represent the relationships that can be established between mobility infrastructure and cultural heritage. Such relationships should be intended in terms of accessibility from mobility infrastructure (motorway exit, service areas, railways stations to cultural heritage localized in the surrounding landscape. The richness of cultural heritage and landscape along the chosen infrastructural bundle represent a great opportunity for territorial development in terms of attractiveness, both for local inhabitants and for tourists. Nowadays, the use of tracking technologies can be applied to investigate tourist flows, behaviors of local inhabitants in the historic city centre, number of visitors in the city and so on. In this sense it is possible to apply these technologies, which are particularly relevant in urban studies, extending them to the territorial scale of the Turin – Milan region. The large amount of available geo-referenced data can be used in different ways and it is very potential for different kind of analysis: it is possible to show tourist flows in the territory, receive information about more visited places, obtain interaction from users and cultural heritage in terms of visitors opinion about the places, give information to tourists about cultural places, monitor the accessibility to the places, understand the use of means of transport and keep under control the impacts of tourism (social, cultural, environmental on territory. Applications based on smartphones can be considered a powerful device for visitors but also for institutions that are involved in tourism and cultural heritage management. In fact, the use of mobile applications it can
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Mobile Applications as Tool for Exploiting Cultural Heritage in the Region of Turin and Milan
Rolando, A.; Scandiffio, A.
2013-07-01
visualization of data flows. In the current research, the field of investigation refers both to the territorial scale of Turin - Milan axis, and to the local scale of small cities localized in the territories in between. The research has been applied to Turin - Milan infrastructural axis, with the aim to represent the relationships that can be established between mobility infrastructure and cultural heritage. Such relationships should be intended in terms of accessibility from mobility infrastructure (motorway exit, service areas, railways stations) to cultural heritage localized in the surrounding landscape. The richness of cultural heritage and landscape along the chosen infrastructural bundle represent a great opportunity for territorial development in terms of attractiveness, both for local inhabitants and for tourists. Nowadays, the use of tracking technologies can be applied to investigate tourist flows, behaviors of local inhabitants in the historic city centre, number of visitors in the city and so on. In this sense it is possible to apply these technologies, which are particularly relevant in urban studies, extending them to the territorial scale of the Turin - Milan region. The large amount of available geo-referenced data can be used in different ways and it is very potential for different kind of analysis: it is possible to show tourist flows in the territory, receive information about more visited places, obtain interaction from users and cultural heritage in terms of visitors opinion about the places, give information to tourists about cultural places, monitor the accessibility to the places, understand the use of means of transport and keep under control the impacts of tourism (social, cultural, environmental) on territory. Applications based on smartphones can be considered a powerful device for visitors but also for institutions that are involved in tourism and cultural heritage management. In fact, the use of mobile applications it can produce a real time data
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Aerosol removal due to precipitation and wind forcings in Milan urban area
Cugerone, Katia; De Michele, Carlo; Ghezzi, Antonio; Gianelle, Vorne
2018-01-01
Air pollution represents a critical issue in Milan urban area (Northern Italy). Here, the levels of fine particles increase, overcoming the legal limits, mostly in wintertime, due to favourable calm weather conditions and large heating and vehicular traffic emissions. The main goal of this work is to quantify the aerosol removal effect due to precipitation at the ground. At first, the scavenging coefficients have been calculated for aerosol particles with diameter between 0.25 and 3 μm. The average values of this coefficient vary between 2 ×10-5 and 5 ×10-5 s-1. Then, the aerosol removal induced separately by precipitation and wind have been compared through the introduction of a removal index. As a matter of fact, while precipitation leads to a proper wet scavenging of the particles from the atmosphere, high wind speeds cause enhanced particle dispersion and dilution, that locally bring to a tangible decrease of aerosol particles' number. The removal triggered by these two forcings showed comparable average values, but different trends. The removal efficiency of precipitation lightly increases with the increase of particle diameters and vice versa happens with strong winds.
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Hameed, Bilal; Mehta, Neil; Sapisochin, Gonzalo; Roberts, John P; Yao, Francis Y
2014-08-01
Serum alpha-fetoprotein (AFP) has been increasingly recognized as a marker for a poor prognosis after liver transplantation (LT) for hepatocellular carcinoma (HCC). Many published reports, however, have included a large proportion of patients with HCC beyond the Milan criteria, and the effects of incorporating AFP as an exclusion criterion for LT remain unclear. We studied 211 consecutive patients undergoing LT for HCC within the Milan criteria according to imaging under the Model for End-Stage Liver Disease organ allocation system between June 2002 and January 2009. The majority (93.4%) had locoregional therapy before LT. The median follow-up was 4.5 years (minimum = 2 years). The Kaplan-Meier 1- and 5-year patient survival rates were 94.3% and 83.4%, respectively. In a univariate analysis, significant predictors of HCC recurrence included vascular invasion [hazard ratio (HR) = 10, 95% confidence interval (CI) = 3.9-26, P 1000 ng/mL (HR = 4.5, 95% CI = 1.3-15.3, P = 0.02), and an AFP level > 500 ng/mL (HR = 3.1, 95% CI = 1.04-9.4, P = 0.04). In a multivariate analysis, vascular invasion was the only significant predictor of tumor recurrence (HR = 5.6, 95% CI = 1.9-19, P = 0.02). An AFP level > 1000 ng/mL was the strongest pretransplant variable predicting vascular invasion (odds ratio = 6.8, 95% CI = 1.6-19.1, P = 0.006). The 1- and 5-year rates of survival without recurrence were 90% and 52.7%, respectively, for patients with an AFP level > 1000 ng/mL and 95% and 80.3%, respectively, for patients with an AFP level ≤ 1000 ng/mL (P = 0.026). Applying an AFP level > 1000 ng/mL as a cutoff would have resulted in the exclusion of 4.7% of the patients fr m LT and a 20% reduction in HCC recurrence. In conclusion, an AFP level > 1000 ng/mL may be a surrogate for vascular invasion and may be used to predict posttransplant HCC recurrence. Incorporating an AFP level > 1000 ng/mL as an exclusion criterion for LT within the Milan criteria may further improve posttransplant
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A multi-source dataset of urban life in the city of Milan and the Province of Trentino.
Barlacchi, Gianni; De Nadai, Marco; Larcher, Roberto; Casella, Antonio; Chitic, Cristiana; Torrisi, Giovanni; Antonelli, Fabrizio; Vespignani, Alessandro; Pentland, Alex; Lepri, Bruno
2015-01-01
The study of socio-technical systems has been revolutionized by the unprecedented amount of digital records that are constantly being produced by human activities such as accessing Internet services, using mobile devices, and consuming energy and knowledge. In this paper, we describe the richest open multi-source dataset ever released on two geographical areas. The dataset is composed of telecommunications, weather, news, social networks and electricity data from the city of Milan and the Province of Trentino. The unique multi-source composition of the dataset makes it an ideal testbed for methodologies and approaches aimed at tackling a wide range of problems including energy consumption, mobility planning, tourist and migrant flows, urban structures and interactions, event detection, urban well-being and many others.
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Model of care for adolescents and young adults with cancer: the Youth Project in Milan
Directory of Open Access Journals (Sweden)
Chiara Magni
2016-08-01
Full Text Available Adolescents and young adults (AYA with cancer form a particular group of patients with unique characteristics, who inhabit a so-called no man’s land between pediatric and adult services. In the last ten years, the scientific oncology community has started to pay attention to these patients, implementing dedicated programs. A standardized model of care directed towards patients in this age range has yet to be developed and neither the pediatric nor the adult oncologic systems perfectly fit these patients’ needs. The Youth Project of the Istituto Nazionale Tumori in Milan, dedicated to adolescents and young adults with pediatric-type solid tumors, can be seen as a model of care for AYA patients, with its heterogeneous multidisciplinary staff and close cooperation with adult medical oncologists and surgeons. Further progress in the care of AYA cancer patients is still needed to improve their outcomes.
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Martín Jiménez, Alfonso
1993-01-01
En su novela "La inmortalidad", Milan Kundera trata el tema de la adaptación de la novela al cine, desarrollando una serie de estrategias encaminadas a volver imposible la adaptación de su novela al cine, como había ocurrido con su obra anterior, "La insoportable levedad del ser". Sin embargo, solo la extensa representación del componente ensayístico-argumentativo propio del mundo del autor, común a muchas de sus novelas, garantiza que la adaptación al cine sea imposible. El cine puede repres...
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International Nuclear Information System (INIS)
Acerbi, E.; Rossi, L.
1988-01-01
The coils of the Milan Superconducting Cyclotron are the largest superconducting devices built up to now in Italy and constitute the first superconducting magnet for accelerator in Europe. Because of the large stored energy (more than 40 MJ), of the high stresses and of of the need of reliability, a lot of measurements were carried out as well on materials used for the coils, both on superconducting cable and structural materials, as on the main components of the coils and on two double pancakes prototypes (wound with full copper cable). In this paper the results on these measurements are reported and the results of tests on the prototypes are discussed. The aim is to provide an easy source of data for superconducting coils useful to verify calculations or to improve the performances
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Bombino, T; Fava, E; Giampieri, E; Santinello, M
1990-01-01
The Maslach Burn Out Inventory (1981) has been applied to a group of workers at three Psychosocial Centres at Milan and Trieste characterised by differing work styles. Point scores were related to a number of variables relative to the professional situation and work organisation. The same scores were related to the results of a questionnaire (Contessa 1987) on the operator's perception of his activity and on motivational factors with respect to the professional choice in actuality and at the beginning of the career. It was therefore possible to identify a set of positive correlations that indicate the presence of factors which increase or reduce B.O. Level.
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Energy Technology Data Exchange (ETDEWEB)
Alessio, R
1973-01-01
Studies on the effects of air pollution on the respiratory tract are reviewed, and an epidemiological survey conducted in Milan, Italy, during the winters of 1969, 1970, and 1971 on 5708 hospitalized patients is presented. In this patient material, bronchopneumopathy accounted for 28 percent. Significant correlation between the respiratory morbidity and the increased air pollution levels, especially the sulfur dioxide and dust concentrations, was established. The reduction of the ambient temperature was accompanied by an increase in the SO/sub 2/ and dust concentrations, and indirectly by a reduction in the rate of recovery of the patients. Studies on the effects of air pollution on the respiratory tract revealed irritation of the respiratory mucosa, bronchial spasms, edema, granulocyte infiltration and sometimes hemorrhge of the bronchial mucosa, hypersecretion, inversion of the direction of fibrillation of the ciliary epithelium, and aggravation of preexisting respiratory affections by SO/sub 2/. Nitrogen oxides, ozone, and automotive exhaust increased the susceptibility of rats to Klebsiella pneumoniae.
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International Nuclear Information System (INIS)
Gardani, G.; Bertoli, M.A.; Bellomi, M.
1987-01-01
Computerised instruction means teaching by computer using a program that alternates information with self-checking multiple choice questions. This system was used to create a fully computerized lesson on the diagnosis and treatment of breast cancer which was then tested on a small group of madical students attending the Radiology School of the Milan University Institute of Radiological Sciences. At the end of the test, the students were asked to complete a questionnaire which was then analysed. The computer lesson consisted of 66 text messages and 21 self-checking questions. It aroused considerable interest, though the most common reason was curiosity about a novel system. The degree of fatigue caused was modest despite the fact that the computer lesson was at least as demanding as a traditional lesson, if not more so. The level of learning was considered high and optimised by the use of self-checking questions that were considered an essential element. However no student agreed to sit an official examination, even interactively, using the computer
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Directory of Open Access Journals (Sweden)
Gabriele Guidi
2017-09-01
Full Text Available This paper presents the methodological approach and the actual workflow for creating the 3D digital reconstruction in time of the ancient Roman Circus of Milan, which is presently covered completely by the urban fabric of the modern city. The diachronic reconstruction is based on a proper mix of quantitative data originated by current 3D surveys and historical sources, such as ancient maps, drawings, archaeological reports, restrictions decrees, and old photographs. When possible, such heterogeneous sources have been georeferenced and stored in a GIS system. In this way the sources have been analyzed in depth, allowing the deduction of geometrical information not explicitly revealed by the material available. A reliable reconstruction of the area in different historical periods has been therefore hypothesized. This research has been carried on in the framework of the project Cultural Heritage Through Time—CHT2, funded by the Joint Programming Initiative on Cultural Heritage (JPI-CH, supported by the Italian Ministry for Cultural Heritage (MiBACT, the Italian Ministry for University and Research (MIUR, and the European Commission.
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Kornberg, A.
2014-01-01
The implementation of the Milan criteria (MC) in 1996 has dramatically improved prognosis after liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Liver transplantation has, thereby, become the standard therapy for patients with “early-stage” HCC on liver cirrhosis. The MC were consequently adopted by United Network of Organ Sharing (UNOS) and Eurotransplant for prioritization of patients with HCC. Recent advancements in the knowledge about tumor biology, radiographic imaging techniques, locoregional interventional treatments, and immunosuppressive medications have raised a critical discussion, if the MC might be too restrictive and unjustified keeping away many patients from potentially curative LT. Numerous transplant groups have, therefore, increasingly focussed on a stepwise expansion of selection criteria, mainly based on tumor macromorphology, such as size and number of HCC nodules. Against the background of a dramatic shortage of donor organs, however, simple expansion of tumor macromorphology may not be appropriate to create a safe extended criteria system. In contrast, rather the implementation of reliable prognostic parameters of tumor biology into selection process prior to LT is mandatory. Furthermore, a multidisciplinary approach of pre-, peri-, and posttransplant modulating of the tumor and/or the patient has to be established for improving prognosis in this special subset of patients. PMID:27335840
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Ruprecht, Ario A; Invernizzi, Giovanni
2009-01-01
the city of Milan introduced a traffic charging zone in city center in January 2008, named Ecopass. to compare PM1, PM2,5 and PM10 levels in and outside the restricted area before and after the enforcement of the charging scheme. PM1, PM2,5 and PM10 exposures were measured by means of pre-calibrated portable laser-operated particle analyzers. PM10 data from the ARPA official monitoring stations were also evaluated. during a walking trip from Piazza Loreto (outside) to Piazza Duomo (inside Ecopass zone) and back, mean (SD) PM1, PM2,5 and PM10 were 31 (6), 68 (24) and 93 (37) microg/m3 inside the Ecopass zone, and 32 (6), 70 (37), 98 (48) microg/m3 in the outer area, respectively (not significant, ns). In another trip walking from Piazza Buonarroti to Piazza Duomo and back, PM1, PM2,5 and PM10 levels were 56 (2), 183 (14) and 245 (28) microg/m3 inside the Ecopass zone, and 58 (3), 197 (13) and 247 (24) microg/m3 in the outer area, respectively (ns). In the measurements taken from a car moving in three ring belts--one inside the restricted zone, and two outer radial orbitals--PM1, PM2,5 and PM10 levels were found 41 (1), 110 (8) and 148 (16) microg/m3 inside the Ecopass area, 42 (3), 116 (14) and 152 (28) microg/m3 along the middle belt, and 39 (4), 102 (15) and 127 (23) microg/m3 along the greater Milan orbital ("Tangenziale"), respectively (ns). Mean (SD) PM10 levels from ARPA in the two months before the enforcement were 71.2 (32.6) and 74.8 (38.4) microg/m3, in the Ecopass zone and outside, respectively while after the enforcement were 67.3 (36.4) and 70.9 (38.3) microg/m3 of PM10, respectively (ns). no signficant improvement in air quality was observed after the enforcement of the Ecopass charging zone in Milan. In spite of their limitations, the present data confirm that small scale reductions in particle emissions are not sufficient to reach the goal of an improvement in air quality. Large scale, coordinated interventions on an inter-regional basis are
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Directory of Open Access Journals (Sweden)
Claudio Giorgione
2009-06-01
Full Text Available Drawing on the example of Leonardo da Vinci, who was able to combine arts and science in his work, the National Museum of Science and Technology of Milan has always pursued the blending and the dialogue of humanistic and scientific knowledge. It has employed this approach in all of its activities, from the set design of exhibition departments to the acquisition of collections and, more recently, in the dialogue with the public. Now more than ever, following a renewal path for the Museum, these guidelines are being subject to research to achieve a new and more up-to-date interpretation.
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大谷, 毅; 池田, 和子; 伊崎, 晴子; 正田, 康博; 森川, 英明
2012-01-01
The Japanese fashion business has a low international presence. While it had been skillful in the import and licensing businesses, these businesses do not involve schemes for selling fashion goods on the global market through proactive entrepreneurial creativity. For this reason, one of the research themes of this study is to clarify the features of the design and manufacturing processes in a Milan fashion house (couture-maison) built on a high level of creativity. The following findings were...
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Adverse biological effects of Milan urban PM looking for suitable molecular markers of exposure
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Mantecca Paride
2012-01-01
Full Text Available The results presented summarise the ones obtained in the coordinated research project Tosca, which extensively analysed the impact of Milan urban PM on human health. The molecular markers of exposure and effects of seasonally and size-fractionated PMs (summer and winter PM10, PM2.5 were investigated in in vitro (human lung cell lines and in vivo (mice systems. The results obtained by the analyses of cytotoxic, pro-inflammatory and genotoxic parameters demonstrate that the biological responses are strongly dependent upon the PM samples seasonal and dimensional variability, that ultimately reflect their chemical composition and source. In fact summer PM10, enriched in crustal elements and endotoxins, was the most cytotoxic and pro-inflammatory fraction, while fine winter PMs induced genotoxic effects and xenobiotic metabolizing enzymes (like CYP1B1 production, likely as a consequence of the higher content in combustion derived particles reach in PAHs and heavy toxic metals. These outcomes outline the need of a detailed knowledge of the PMs physico-chemical composition on a local scale, coupled with the biological hazard directly associated to PM exposure. Apparently this is the only way allowing scientists and police-makers to establish the proper relationships between the respirable PM quantity/quality and the health outcomes described by clinicians and epidemiologists.
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Milan PM1 induces adverse effects on mice lungs and cardiovascular system.
Farina, Francesca; Sancini, Giulio; Longhin, Eleonora; Mantecca, Paride; Camatini, Marina; Palestini, Paola
2013-01-01
Recent studies have suggested a link between inhaled particulate matter (PM) exposure and increased mortality and morbidity associated with cardiorespiratory diseases. Since the response to PM1 has not yet been deeply investigated, its impact on mice lungs and cardiovascular system is here examined. A repeated exposure to Milan PM1 was performed on BALB/c mice. The bronchoalveolar lavage fluid (BALf) and the lung parenchyma were screened for markers of inflammation (cell counts, tumor necrosis factor-α (TNF-α); macrophage inflammatory protein-2 (MIP-2); heme oxygenase-1 (HO-1); nuclear factor kappa-light-chain-enhancer of activated B cells p50 subunit (NFκB-p50); inducible nitric oxide synthetase (iNOS); endothelial-selectin (E-selectin)), cytotoxicity (lactate dehydrogenase (LDH); alkaline phosphatase (ALP); heat shock protein 70 (Hsp70); caspase-8-p18), and a putative pro-carcinogenic marker (cytochrome 1B1 (Cyp1B1)). Heart tissue was tested for HO-1, caspase-8-p18, NFκB-p50, iNOS, E-selectin, and myeloperoxidase (MPO); plasma was screened for markers of platelet activation and clot formation (soluble platelet-selectin (sP-selectin); fibrinogen; plasminogen activator inhibitor 1 (PAI-1)). PM1 triggers inflammation and cytotoxicity in lungs. A similar cytotoxic effect was observed on heart tissues, while plasma analyses suggest blood-endothelium interface activation. These data highlight the importance of lung inflammation in mediating adverse cardiovascular events following increase in ambient PM1 levels, providing evidences of a positive correlation between PM1 exposure and cardiovascular morbidity.
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Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System
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Francesca Farina
2013-01-01
Full Text Available Recent studies have suggested a link between inhaled particulate matter (PM exposure and increased mortality and morbidity associated with cardiorespiratory diseases. Since the response to PM1 has not yet been deeply investigated, its impact on mice lungs and cardiovascular system is here examined. A repeated exposure to Milan PM1 was performed on BALB/c mice. The bronchoalveolar lavage fluid (BALf and the lung parenchyma were screened for markers of inflammation (cell counts, tumor necrosis factor-α (TNF-α; macrophage inflammatory protein-2 (MIP-2; heme oxygenase-1 (HO-1; nuclear factor kappa-light-chain-enhancer of activated B cells p50 subunit (NFκB-p50; inducible nitric oxide synthetase (iNOS; endothelial-selectin (E-selectin, cytotoxicity (lactate dehydrogenase (LDH; alkaline phosphatase (ALP; heat shock protein 70 (Hsp70; caspase-8-p18, and a putative pro-carcinogenic marker (cytochrome 1B1 (Cyp1B1. Heart tissue was tested for HO-1, caspase-8-p18, NFκB-p50, iNOS, E-selectin, and myeloperoxidase (MPO; plasma was screened for markers of platelet activation and clot formation (soluble platelet-selectin (sP-selectin; fibrinogen; plasminogen activator inhibitor 1 (PAI-1. PM1 triggers inflammation and cytotoxicity in lungs. A similar cytotoxic effect was observed on heart tissues, while plasma analyses suggest blood-endothelium interface activation. These data highlight the importance of lung inflammation in mediating adverse cardiovascular events following increase in ambient PM1 levels, providing evidences of a positive correlation between PM1 exposure and cardiovascular morbidity.
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Lust, Teresa A; Paris, Harry S
2016-07-01
Summer squash, the young fruits of Cucurbita pepo, are a common, high-value fruit vegetable. Of the summer squash, the zucchini, C. pepo subsp. pepo Zucchini Group, is by far the most cosmopolitan. The zucchini is easily distinguished from other summer squash by its uniformly cylindrical shape and intense colour. The zucchini is a relatively new cultivar-group of C. pepo, the earliest known evidence for its existence having been a description in a book on horticulture published in Milan in 1901. For this study, Italian-language books on agriculture and cookery dating from the 16th to 19th centuries have been collected and searched in an effort to follow the horticultural development and culinary use of young Cucurbita fruits in Italy. The results indicate that Cucurbita fruits, both young and mature, entered Italian kitchens by the mid-16th century. A half-century later, round and elongate young fruits of C. pepo were addressed as separate cookery items and the latter had largely replaced the centuries-old culinary use of young, elongate bottle gourds, Lagenaria siceraria Allusion to a particular, extant cultivar of the longest fruited C. pepo, the Cocozelle Group, dates to 1811 and derives from the environs of Naples. The Italian diminutive word zucchini arose by the beginning of the 19th century in Tuscany and referred to small, mature, desiccated bottle gourds used as containers to store tobacco. By the 1840s, the Tuscan word zucchini was appropriated to young, primarily elongate fruits of C. pepo The Zucchini Group traces its origins to the environs of Milan, perhaps as early as 1850. The word zucchini and the horticultural product zucchini arose contemporaneously but independently. The results confirm that the Zucchini Group is the youngest of the four cultivar-groups of C. pepo subsp. pepo but it emerged approximately a half-century earlier than previously known. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany
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Monitoring emerging contaminants in the drinking water of Milan and assessment of the human risk.
Riva, Francesco; Castiglioni, Sara; Fattore, Elena; Manenti, Angela; Davoli, Enrico; Zuccato, Ettore
2018-04-01
Emerging Contaminants (ECs) are ubiquitous in waters, arousing concern because of their potential risks for human health and the environment. This study investigated the presence of multiple classes of ECs in 21 wells over the drinking water network of Milan, in the most inhabited and industrialized area of Italy, and assessed the risks for consumers. Samples were analyzed using liquid chromatography coupled to mass spectrometry. Human risk assessment (HRA) was conducted by comparing the measured concentrations with drinking water thresholds from guidelines or calculated in this study; first considering the exposure to each single EC and then the entire mixture. Thirteen ECs were measured in the low ng/L range, and were generally detected in less than half of the wells. Pharmaceuticals, perfluorinated substances, personal care products, and anthropogenic markers were the most frequently detected. The results of the HRA excluded any risks for consumers in each scenario considered. This is one of the most comprehensive studies assessing the presence of a large number of ECs in the whole drinking water network of a city, and the risks for human health. Results improve the limited information on ECs sources and occurrence in drinking water and help establishing guidelines for regulatory purposes. Copyright © 2018 Elsevier GmbH. All rights reserved.
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Surveillance of Mosquitoes and Selected Arthropod-Borne Viruses in the Context of Milan EXPO 2015
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Mario Chiari
2016-07-01
Full Text Available From 1 May 2015 to 31 October 2015 over 20 million visitors from all over the world visited the Universal Exhibition (EXPO hosted by Milan (Lombardy region, Italy, raising concerns about the possible introduction of mosquito-borne diseases from endemic countries. The entomological surveillance protocol performed in Lombardy over the last three years was implemented in the EXPO area and in the two major regional airports using both Center for Disease Control CO2 and Biogents Sentinel traps. This surveillance aimed to estimate the presence and densities of putative vectors, and also to support investigations, including the vector species involved and area of diffusion, on the local spread of Chikungunya, Dengue and West Nile viruses (WNV by competent vectors. From 3544 mosquitoes belonging to five different species, 28 pools of Culex spp. and 45 pools of Aedes spp. were screened for the presence of WNV, and for both Chikungunya and flaviviruses, respectively. The entomological surveillance highlighted a low density of potential vectors in the surveyed areas and did not reveal the presence of Chikungunya or Dengue viruses in the local competent vectors inside the EXPO area or in the two airports. In addition, the surveillance reported a low density of Culex spp. mosquitoes, which all tested negative for WNV.
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Assessing Natural Background Levels of aquifers in the Metropolitan Area of Milan (Lombardy)
De Caro, Mattia; Crosta, Giovanni; Frattini, Paolo
2016-04-01
The European Water Framework Directive (WFD 2000/60/CE) requires Member States to evaluate the status of groundwater bodies in order to reach a good water quality for human consumption. One of the preliminary steps for defining the status of groundwater bodies consists in the definition and evaluation of the so-called Natural Background Levels (NBL). The NBL or Baseline level can be defined as "the range of concentration of a given element, isotope or chemical compound in solution, derived entirely from natural, geological, biological or atmospheric sources, under conditions not perturbed by anthropogenic activity" (Edmund and Shand, 2009). The qualitative analysis for a large area (ca 4500 Km2) of the Po Plain around the Milan Metropolitan area (Lombardy, Italy) is presented in this study. Despite the aquifers in the Milan metropolitan area are an incredible groundwater resource for a very large population (3.195.629 inhabitants in the metropolitan area, data at November 2014) and a highly industrialized area, a groundwater baseline characterization is still missing. In order to attain the hydro-geochemical characterization a complete geodatabase was built (120.655 chemical samples from 1980 to 2014). This database has been explored by classical and multivariate statistical analyses to provide relationships among the more influential lithological, hydrogeological and hydro-chemical variables. Finally, the NBLs of different chemical species which may be anthropogenic sensitive (Na, Cl, K, NO3, SO4, NH4, As, Fe, Cr, Fe, Mn, Zn) and for multiple aquifer bodies (phreatic, semi-confined and confined aquifer) are evaluated. Two different approaches are applied: the Pre-Selection method (BRIDGE, 2006) and the Component-Separation method. The first one (PS) consists in the exclusion of samples from the available dataset that could indicate human activities then deriving the NBL as the 90th percentile of the remaining data. The second one (CS) consists in the fitting of
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Directory of Open Access Journals (Sweden)
Claudio Giorgione
2009-06-01
Full Text Available Drawing on the example of Leonardo da Vinci, who was able to combine arts and science in his work, the National Museum of Science and Technology of Milan has always pursued the blending and the dialogue of humanistic and scientific knowledge. It has employed this approach in all of its activities, from the set design of exhibition departments to the acquisition of collections and, more recently, in the dialogue with the public. Now more than ever, following a renewal path for the Museum, these guidelines are being subject to research to achieve a new and more up-to-date interpretation.
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A developmental theory of synaesthesia, with long historical roots: a comment on Hochel & Milan.
Holcombe, Alex O; Altschuler, Eric L; Over, Harriet J
2009-03-01
The recent surge of scientific investigation into synaesthesia, ably reviewed by Hochel and Milan (2008), is representative of an increasing recognition that our various sensory modalities are intimately interconnected rather than separate. The origin of these interconnections is the subject of an intriguing theory by Maurer and Maurer (1988). They suggest that all of us begin life as synaesthetes, with subsequent neural development reducing the connections among the senses. We present some historical roots of the idea that human life begins with the senses intertwined. The influential 18th-century philosopher Jean-Jacques Rousseau described an early theory of child development in his book Emile (1762), hypothesizing that if "a child had at its birth the stature and strength of a man ... all his sensations would be united in one place, they would exist only in the common 'sensorium'." A half-century later, a young Mary Shelley (1818) brought this idea into popular culture with the Frankenstein creature's recollection of his early experience: "A strange multiplicity of sensations seized me, and I saw, felt, heard, and smelt, at the same time; and it was, indeed, a long time before I learned to distinguish between the operations of my various senses." William James in The Principles of Psychology (1890) expressed a similar idea. In this context, the assumption of many 20th-century scientists that the senses were largely separate appears to be an historical aberration.
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[The written nursing reports of the asylum "Paolo Pini" of Milan, from 1944 to 1947].
Negri, Marina; Marchesini, Vanna; De Valerio, Silvio; Soro, Emiliana
2017-01-01
The work provides the analysis of the nursing reports written by the nursing staff on duty at the asylum "Paolo Pini" from 1944 to 1947. description of the nursing report evolution, analyses of the quantitative and qualitative matters. Study of the evolution of the records: enhancement of the description of the patient, integration between medical and nursing assistance, assumption of responsi- bility (for instance through the signature). A sampling of 355 medical records has been analysed. The nursing records have been identified according to the theoretical model of Marisa Cantarelli. They have been compared with the current standard reported in literature. If recognizable signatures were present, they have been checked in the archives of the Province of Milan. 219 records concerning nursing assistance have been selected. The record changed during the years assuming a definite structure, and became a pre printed form; its use spread in all the wards of the hospital. The record deals with nursing assistance needs, and improves during the years becoming more and more detailed and regular. During the analysed time frame, the nursing reports at "Paolo Pini" improve and become more exhaustive and regular; they prove to be part of the medical record, showing a good integration between doctors and nurses activities. The evolution of this tool confirms the need of highlighting and improving the assistance practice.
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Sangiorgi, G; Ferrero, L; Perrone, M G; Bolzacchini, E; Duane, M; Larsen, B R
2011-12-01
A novel approach for measuring vertical profiles of HCs and particle number concentrations was described and applied in the low troposphere over Milan (Italy) during typical spring and summer days. Particle profiles yielded nearly homogeneous concentrations below the mixing height, with level-to-ground concentration ratios of 92-97%, while HCs showed a more pronounced decrease (74-95%). Vertical mixing and photochemical loss of HCs were demonstrated to cause these gradients. Much lower concentrations were observed for the profiles above the mixing height, where the HC mixtures showed also a different composition, which was partially explained by the horizontal advection of air with HC sources different to those prevailing at the site. The application of pseudo-first order kinetics for reactions between HCs and the hydroxyl radical allowed for the estimation of the vertical mixing time scale in the order of 100 ± 20 min. Copyright © 2011 Elsevier Ltd. All rights reserved.
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International Nuclear Information System (INIS)
Chiesa, M.; Perrone, M.G.; Cusumano, N.; Ferrero, L.; Sangiorgi, G.; Bolzacchini, E.; Lorenzoni, A.; Ballarin Denti, A.
2014-01-01
Highlights: • PM10 and NO x emission reduction by different policies have been estimated. • Various actions have been considered, in the transport and residential sectors. • Environmental, economic and socio-political data were jointly evaluated. • Results are reported for the case study of the Province of Milan (Northern Italy). • Bike use fostering best matches cost–benefit results and socio-political acceptance. - Abstract: In the frame of urban air-pollution reduction policies, economic costs and environmental benefits of a variety of actions have been quantitatively assessed for the Province of Milan (Northern Italy), focusing on PM10 and NO x emission sources. Short-to-mid-term interventions that have been taken into consideration include reduction of inner temperature in residential buildings, banning of residential biomass heating systems, banning of diesel fuelled domestic boilers, night-time streets washing, speed limit reduction on highways, circulation restrictions of oldest EURO vehicles, conversion of diesel buses to natural gas, car sharing/biking promotion, DPF adoption in diesel vehicles, extension of road lanes for urban buses, energy efficiency refurbishment in residential buildings. Re*sults emerged from the cost–benefit analysis integrated with socio-political indicators obtained through direct surveys, will contribute, with an holistic and multidisciplinary approach, to drive the local administrators to implement the most suitable actions in one of the most polluted areas in west-Europe
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Solís de la Paz, Dayma; Peñate Brito, Jayne Bárbara
2011-01-01
La magnetoterapia, aunque ha sido utilizada para diversas afecciones ortopédicas, no se ha empleado en la tendinitis asociada al láser y a los ejercicios terapéuticos, por lo que se realizó un estudio explicativo, experimental, tipo ensayo clínico terapéutico, para comprobar la eficacia de esta terapia en pacientes con tendinitis en el Servicio de Rehabilitación Integral José Jacinto Milanés. Se conformaron dos grupos con 42 pacientes, uno experimental con aplicación local de campos magnético...
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Enterovirus D68-associated community-acquired pneumonia in children living in Milan, Italy.
Esposito, Susanna; Zampiero, Alberto; Ruggiero, Luca; Madini, Barbara; Niesters, Hubert; Principi, Nicola
2015-07-01
An increasing number of children infected by enterovirus D68 (EV-D68) and affected by severe respiratory illness, muscle weakness and paralysis were described in the USA and Canada in 2014 OBJECTIVES: To investigate the potential involvement of EV-D68 in determining community-acquired pneumonia (CAP) in hospitalised children in order to acquire information concerning the clinical problems associated with EV-D68 in Italy. This prospective study of children hospitalised for CAP in the largest Pediatric Department in Milan, Italy, was carried out between 1 June and 31 December 2014. All of the children's admission nasopharyngeal swabs were investigated for the presence of EV-D68. One hundred and seventy-six children with radiographically confirmed CAP were hospitalised during the 7-month study period: 97 (55.1%) had enterovirus/rhinovirus-positive nasopharyngeal samples, including four (2.3%) positive for EV-D68. These four samples were collected between 9 and 21 October, a month in which 21 cases of CAP were recorded. Phylogenetic analysis showed that all of the sequences fell into clade B. The most severe case was diagnosed in a 14-year-old girl with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS syndrome), who died after 12 days of hospitalisation. EV-D68 was detected in few children with usually mild-to-moderate lower respiratory tract infection, although the disease lead to the death of a girl with a severe chronic underlying disease. Further studies capable of better defining the epidemiological, genetic and pathogenetic characteristics of the virus are required in order to be able to prepare appropriate preventive and therapeutic measures. Copyright © 2015 Elsevier B.V. All rights reserved.
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Milan hypertensive rat as a model for studying cation transport abnormality in genetic hypertension
International Nuclear Information System (INIS)
Ferrari, P.; Barber, B.R.; Torielli, L.; Ferrandi, M.; Salardi, S.; Bianchi, G.
1987-01-01
Environmental factors, genetic polymorphisms, and different experimental designs have been the main impediments to evaluating a genetic association between cell membrane cation transport abnormalities and human essential or genetic hypertension. We review the results obtained in the Milan hypertensive strain of rats (MHS) and in its appropriate control normotensive strain (MNS) to illustrate our approach to defining the role of cation transport abnormality in a type of genetic hypertension. Before the development of a difference in blood pressure between the two strains, the comparison of kidney and erythrocyte functions showed that MHS had an increased glomerular filtration rate and urinary output, and lower plasma renin and urine osmolality. Kidney cross-transplantation between the strains showed that hypertension is transplanted with the kidney. Proximal tubular cell volume and sodium content were lower in MHS while sodium transport across the brush border membrane vesicles of MHS was faster. Erythrocytes in MHS were smaller and had lower sodium concentration, and Na+-K+ cotransport and passive permeability were faster. The differences in volume, sodium content, and Na+-K+ cotransport between erythrocytes of the two strains persisted after transplantation of bone marrow to irradiated F1 (MHS X MNS) hybrids. Moreover, in normal segregating F2 hybrid populations there was a positive correlation between blood pressure and Na+-K+ cotransport. These results suggest a genetic and functional link in MHS between cell membrane cation transport abnormalities and hypertension. Thus, erythrocyte cell membrane may be used for approaching the problem of defining the genetically determined molecular mechanism underlying the development of a type of essential hypertension. 35 references
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Prunas, Antonio; Clerici, Carlo Alfredo; Gentile, Guendalina; Muccino, Enrico; Veneroni, Laura; Zoja, Riccardo
2015-10-01
In Europe, 71 murders resulting in the death of transgendered persons were reported between 2008 and 2013, 20 of which perpetrated in Italy, the second highest rate in Europe after Turkey. We retrospectively analyzed the homicides of transgender people recorded at the Medicolegal Bureau in Milan from January 1993 to December 2012. First we considered the sociodemographic data of 20 victims and the circumstantial details of their deaths, then we examined the data related to the cause of death from the autopsy reports. Our data show that victims are mostly immigrants, biological males presenting with a feminine attire and with varying degrees of feminization. The large majority of the victims were sex workers from South America. As for murderers, they were unknown in 7 cases (35%); all the 13 murderers identified were males, aged between 17 and 63 (M age = 31 years). In 38% of the cases, the murderer was the victim's current or former partner. For half of the homicides, it was possible to identify at least one primary indicator of lesbian, gay, bisexual, and transgender (LGBT) hate crime. Our findings call for the need to make explicit in Italian legislation that a crime perpetrated on the ground of sexual orientation and gender identity constitutes a hate crime. © The Author(s) 2014.
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Panteghini, Mauro; Ceriotti, Ferruccio; Jones, Graham; Oosterhuis, Wytze; Plebani, Mario; Sandberg, Sverre
2017-10-26
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications. The laboratory community has used different models to set performance specifications (PS). Recently, it was felt that there was a need to revisit different models and, at the same time, to emphasize the presuppositions for using the different models. Therefore, in 2014 the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) organized a Strategic Conference in Milan. It was felt that there was a need for more detailed discussions on, for instance, PS for EQAS, which measurands should use which models to set PS and how to set PS for the extra-analytical phases. There was also a need to critically evaluate the quality of data on biological variation studies and further discussing the use of the total error (TE) concept. Consequently, EFLM established five Task Finish Groups (TFGs) to address each of these topics. The TFGs are finishing their activity on 2017 and the content of this paper includes deliverables from these groups.
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Punzi, Silvia; Cassitto, Maria Grazia; Castellini, Giovanna; Costa, G; Gilioli, R
2007-01-01
There is increasing interest in research, prevention and management of mobbing in the field of occupational psychosocial risks. To describe mobbing and its health effects by analysis of the cases examined from 1997 to 2003 at the Department of Occupational Health "Clinica del Lavoro Luigi Devoto" in Milan. A total of 226 clinical records of patients who reported a mobbing situation when undergoing medical examination were selected out of 2455 patients examined for stress-related disorders. The percentage of women was higher (53.1%) than in men (46.9%) with a prevalent age range of 35-54 years. There was a great variety of jobs, especially white-collars and workers in large service companies. In one third of the cases, mobbing occurred within 4 years from beginning of employment and mostly after company reorganization and management changes. The most frequent negative acts included social isolation and demotion. The most frequent symptoms were exhaustion, sleep, mood and sexual disorders. The number of symptoms was not related to the duration of mobbing but to the number and frequency of negative actions. 61.1% of the subjects took psychotropic drugs. Occupational health physicians play an essential role in primary prevention (information on occupational risks) and in early diagnosis and rehabilitation and could act as mediators between workers and enterprises.
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From groundwater baselines to numerical groundwater flow modelling for the Milan metropolitan area
Crosta, Giovanni B.; Frattini, Paolo; Peretti, Lidia; Villa, Federica; Gorla, Maurizio
2015-04-01
Contamination of major aquifers in highly densely populated areas is a major concern for stakeholders involved in the use and protection of groundwater resources. Sustainable groundwater withdrawal and management, and the identification of trends in groundwater contamination require a careful hydrochemical baseline characterization. This characterization is fundamental to investigate the presence and evolutionary trend of contaminants. In fact, it allows recovering and understanding: the spatial-temporal trend of contamination; the relative age of the contamination episodes; the reasons for anomalous behavior of some compounds during migration to and in the groundwater; the associations with which some contaminants can be found; the different behaviors in phreatic and semi-confined and confined aquifers. To attain such a characterization for the Milan metropolitan area (about 2,500 km2, ca 4.000.000 inhabitants, Lombardy, Italy), we carried out three main activities. (1) Collection of complete and reliable datasets concerning the geological, hydrogeological and hydrochemical (over 60,000 chemical analysis since 2003 to 2013) characteristics of the area and of the involved aquifers. This activity was very demanding because the available data are provided by different authorities (Lombardy Region, Provinces, Lombardy Environmental Agency - ARPA Lombardia, public own companies in charge of water system managements) in raw format and with different database standard, which required a large effort of manual verification and harmonization. (2) Completion of a hydrochemical characterization of the metropolitan area aquifers by classical statistical and multivariate statistical analyses, in order to define a baseline both for some major physical chemical characteristics and for the most relevant contaminants. (3) Development of a three dimensional hydrogeological model for the metropolitan area starting from the above listed datasets and existing models. This model will
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Santus, Pierachille; Russo, Antonio; Madonini, Enzo; Allegra, Luigi; Blasi, Francesco; Centanni, Stefano; Miadonna, Antonio; Schiraldi, Gianfranco; Amaducci, Sandro
2012-10-18
Environmental pollution is a known risk factor for multiple diseases and furthermore increases rate of hospitalisations. We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy. We collected data from 45770 ERAs for respiratory diseases. A time-stratified case-crossover design was used to investigate the association between air pollution levels and ERAs for acute respiratory conditions. The effects of air pollutants were investigated at lag 0 to lag 5, lag 0-2 and lag 3-5 in both single and multi-pollutant models, adjusted for daily weather variables. An increase in ozone (O(3)) levels at lag 3-5 was associated with a 78% increase in the number of ERAs for asthma, especially during the warm season. Exposure to carbon monoxide (CO) proved to be a risk factor for pneumonia at lag 0-2 and in the warm season increased the risk of ERA by 66%. A significant association was found between ERAs for COPD exacerbation and levels of sulphur dioxide (SO(2)), CO, nitrate dioxide (NO(2)), and particulate matter (PM(10) and PM(2.5)). The multipollutant model that includes all pollutants showed a significant association between CO (26%) and ERA for upper respiratory tract diseases at lag 0-2. For chronic obstructive pulmonary disease (COPD) exacerbations, only CO (OR 1.19) showed a significant association. Exposure to environmental pollution, even at typical low levels, can increase the risk of ERA for acute respiratory diseases and exacerbation of obstructive lung diseases in the general population.
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International Nuclear Information System (INIS)
Robinson, W.P.
1998-01-01
Since as early as 1975, groundwater contamination from New Mexico uranium mill tailings has been investigated with two sites -Homestake-Milan and United Nuclear-Church Rock -showing severe enough groundwater damage to merit listing on the US Environmental Protection Agency's (EPA) Superfund National Priority List -a nationwide list based on severity of pollution and water resource usefulness. These two sites provide valuable case studies for the first - 1950s -and second - 1970s -generations of uranium mill tailings facilities demonstrating the severity of contamination which ineffective control can allow and the challenge of full scale groundwater restoration. While the groundwater restoration at these sites began in the 1970s and 1980s, active treatment is anticipated into the 21st century. This paper summarizes the groundwater restoration programs at two of these sites - Homestake Mining Company's (HMC) Milan Mill (now called the ''Grants Project'') and United Nuclear Corporation's (UNC) Church Rock Mill. The two sites are summarized with respect to operations, groundwater impact, tailings disposal systems, hydrogeological characteristics of the site and affected areas, applicable standards, and remedial technology applied. This review provides a basis for initial comparisons with uranium mill tailings groundwater restoration challenges outside the USA. These sites provide an important benchmark the complexity of restoration at for large-scale uranium mill tailings sites. The longevity of the restoration efforts demonstrate the results of low-intensity responses to contamination upon detection and delayed enforcement actions. These ''witnesses'' to the value of effective pollution prevention in tailings design and full review and monitoring of tailings operations, have potential to be models of effective groundwater restoration. (orig.)
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Zanzani, Sergio Aurelio; Di Cerbo, Anna Rita; Gazzonis, Alessia Libera; Genchi, Marco; Rinaldi, Laura; Musella, Vincenzo; Cringoli, Giuseppe
2014-01-01
Intestinal parasites of dogs represent a serious threat to human health due to their zoonotic potential. Thus, metropolitan areas presenting high concentrations of pets and urban fecal contamination on public areas are at sanitary risk. Major aim of this survey was to determine prevalence of zoonotic parasites in dog fecal samples collected from public soil of Milan (north-western Italy). Differences in parasites prevalence distribution were explored by a geographical information system- (GIS-) based approach, and risk factors (human density, sizes of green parks, and dog areas) were considered. The metropolitan area was divided into 157 rectangular subareas and sampling was performed following a 1-kilometer straight transect. A total of 463 fecal samples were analyzed using centrifugation-flotation technique and ELISA to detect Giardia and Cryptosporidium coproantigens. A widespread fecal contamination of soil was highlighted, being fecal samples found in 86.8% of the subareas considered. The overall prevalence of intestinal parasites was 16.63%. Zoonotic parasites were found, such as Trichuris vulpis (3.67%), Toxocara canis (1.72%), Strongyloides stercoralis (0.86%), Ancylostomatidae (0.43%), and Dipylidium caninum (0.43%). Giardia duodenalis was the most prevalent zoonotic protozoa (11.06%), followed by Cryptosporidium (1.10%). Faeces from subareas characterized by broad green areas showed to be particularly prone to infection. PMID:25478583
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Directory of Open Access Journals (Sweden)
Sergio Aurelio Zanzani
2014-01-01
Full Text Available Intestinal parasites of dogs represent a serious threat to human health due to their zoonotic potential. Thus, metropolitan areas presenting high concentrations of pets and urban fecal contamination on public areas are at sanitary risk. Major aim of this survey was to determine prevalence of zoonotic parasites in dog fecal samples collected from public soil of Milan (north-western Italy. Differences in parasites prevalence distribution were explored by a geographical information system- (GIS- based approach, and risk factors (human density, sizes of green parks, and dog areas were considered. The metropolitan area was divided into 157 rectangular subareas and sampling was performed following a 1-kilometer straight transect. A total of 463 fecal samples were analyzed using centrifugation-flotation technique and ELISA to detect Giardia and Cryptosporidium coproantigens. A widespread fecal contamination of soil was highlighted, being fecal samples found in 86.8% of the subareas considered. The overall prevalence of intestinal parasites was 16.63%. Zoonotic parasites were found, such as Trichuris vulpis (3.67%, Toxocara canis (1.72%, Strongyloides stercoralis (0.86%, Ancylostomatidae (0.43%, and Dipylidium caninum (0.43%. Giardia duodenalis was the most prevalent zoonotic protozoa (11.06%, followed by Cryptosporidium (1.10%. Faeces from subareas characterized by broad green areas showed to be particularly prone to infection.
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Energy Technology Data Exchange (ETDEWEB)
Sangiorgi, G., E-mail: giorgia.sangiorgi1@unimib.it [POLARIS Research Centre, Department of Environmental Sciences, University of Milano-Bicocca, piazza della Scienza 1, 20126 Milano (Italy); Ferrero, L.; Perrone, M.G.; Bolzacchini, E. [POLARIS Research Centre, Department of Environmental Sciences, University of Milano-Bicocca, piazza della Scienza 1, 20126 Milano (Italy); Duane, M. [Institute for Environment and Sustainability, EU Joint Research Centre Ispra, 21020 Ispra, Varese (Italy); Larsen, B.R. [Institute for Health and Consumer Protection, EU Joint Research Centre Ispra, 21020 Ispra, Varese (Italy)
2011-12-15
A novel approach for measuring vertical profiles of HCs and particle number concentrations was described and applied in the low troposphere over Milan (Italy) during typical spring and summer days. Particle profiles yielded nearly homogeneous concentrations below the mixing height, with level-to-ground concentration ratios of 92-97%, while HCs showed a more pronounced decrease (74-95%). Vertical mixing and photochemical loss of HCs were demonstrated to cause these gradients. Much lower concentrations were observed for the profiles above the mixing height, where the HC mixtures showed also a different composition, which was partially explained by the horizontal advection of air with HC sources different to those prevailing at the site. The application of pseudo-first order kinetics for reactions between HCs and the hydroxyl radical allowed for the estimation of the vertical mixing time scale in the order of 100 {+-} 20 min. - Graphical abstract: Display Omitted Highlights: > Experimental vertical profiles of HCs and particle concentration by tethered balloon. > Effect of mixing height on the vertical distribution of HCs and particles. > Effect of tropospheric reactivity on vertical profiles of HCs. > Pseudo-first order kinetic reaction of HCs in convective systems. - Vertical transport and photochemical loss of HCs below and above the mixing height were studied by means of a novel and simple approach.
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Training and Public Information Activities of the Milan Copic Nuclear Training Centre
International Nuclear Information System (INIS)
Jencic, I.
2006-01-01
The mission of the Milan Copic Nuclear Training Centre is training in the field of nuclear technologies and radioactivity. In addition we are actively informing general public about those technologies. Activities can be divided into four areas: training in the area of nuclear technologies, radiological protection training, organization of international training courses and public information. Training in the area of nuclear technologies is the primary mission. Two types of courses are regularly offered: The Theory of nuclear technology is the initial training of future control room operators, and the Basics of nuclear technology is intended for non-control room personnel of Krsko NPP and for staff of some other organizations. Each year there are also some specific courses in this area, mainly for the regulatory body and for the NPP. Jozef Stefan Institute is one of the two institutions in Slovenia, authorized for radiological protection training and the training centre is the actual performer. About 15 courses yearly are organized for people from medicine, industry and science courses about open, closed and industrial sources of ionizing radiation. We are also responsible for the training of NPP Krsko personnel in that area. Organization of international courses is a usually a collaboration with the International Atomic Energy Agency (IAEA), but we have worked also with other international organizations, such as European Commission, US Department of Energy etc. The topics of international courses and workshops cover a wide range from nuclear safety to radiological protection or illegal trafficking of nuclear materials etc. Depending on the subject, part of lectures on these courses is given by domestic experts. 6 - 10 international courses are organized yearly. Very important is the area of public information. Groups of school children and other visitors are coming regularly to listen to a lecture and to visit the exhibition. In 2005, both the lecture and the
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Directory of Open Access Journals (Sweden)
Arnot Komárek
2014-09-01
Full Text Available R package mixAK originally implemented routines primarily for Bayesian estimation of finite normal mixture models for possibly interval-censored data. The functionality of the package was considerably enhanced by implementing methods for Bayesian estimation of mixtures of multivariate generalized linear mixed models proposed in Komrek and Komrkov (2013. Among other things, this allows for a cluster analysis (classification based on multivariate continuous and discrete longitudinal data that arise whenever multiple outcomes of a different nature are recorded in a longitudinal study. This package also allows for a data-driven selection of a number of clusters as methods for selecting a number of mixture components were implemented. A model and clustering methodology for multivariate continuous and discrete longitudinal data is overviewed. Further, a step-by-step cluster analysis based jointly on three longitudinal variables of different types (continuous, count, dichotomous is given, which provides a user manual for using the package for similar problems.
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International Nuclear Information System (INIS)
Sangiorgi, G.; Ferrero, L.; Perrone, M.G.; Bolzacchini, E.; Duane, M.; Larsen, B.R.
2011-01-01
A novel approach for measuring vertical profiles of HCs and particle number concentrations was described and applied in the low troposphere over Milan (Italy) during typical spring and summer days. Particle profiles yielded nearly homogeneous concentrations below the mixing height, with level-to-ground concentration ratios of 92-97%, while HCs showed a more pronounced decrease (74-95%). Vertical mixing and photochemical loss of HCs were demonstrated to cause these gradients. Much lower concentrations were observed for the profiles above the mixing height, where the HC mixtures showed also a different composition, which was partially explained by the horizontal advection of air with HC sources different to those prevailing at the site. The application of pseudo-first order kinetics for reactions between HCs and the hydroxyl radical allowed for the estimation of the vertical mixing time scale in the order of 100 ± 20 min. - Graphical abstract: Display Omitted Highlights: → Experimental vertical profiles of HCs and particle concentration by tethered balloon. → Effect of mixing height on the vertical distribution of HCs and particles. → Effect of tropospheric reactivity on vertical profiles of HCs. → Pseudo-first order kinetic reaction of HCs in convective systems. - Vertical transport and photochemical loss of HCs below and above the mixing height were studied by means of a novel and simple approach.
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Directory of Open Access Journals (Sweden)
Consolo Silvia
2010-06-01
Full Text Available Abstract Background In order to be widely accepted by users, the implementation of a new health intervention requires them to be adequately informed about its clinical importance, benefits and risks. The aim of this study was to provide data on the knowledge of Italian adolescents and parents concerning human papillomavirus (HPV infection and its prevention in order to allow the development of adequate training programmes. Methods Between 2 May and 15 June 2008, we made a cross-sectional survey of 863 high school students and 2,331 parents of middle and high school students using two anonymously completed questionnaires covering the knowledge of HPV infection and related diseases, and attitudes to vaccinations. The approached schools were a convenience sample of the schools of the greater Milan area, Northern Italy. Results More mothers than fathers were aware that HPV infection could concern their children (58% vs 53%; p = 0.004 and were favourable towards vaccinating their children against HPV (68% vs 65%; p = 0.03; among the students, more females than males were aware that HPV infection could concern themselves (45% vs 26%; p vs 40%; p Conclusions Both students and parents seem to underestimate the likelihood of HPV infection, and this is associated with a lower propensity for vaccination. This is an important indication for future training programmes concerning HPV prevention designed to increase the acceptance of HPV vaccine in families.
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Ferrero, L; Mocnik, G; Ferrini, B S; Perrone, M G; Sangiorgi, G; Bolzacchini, E
2011-06-15
Vertical profiles of aerosol number-size distribution and black carbon (BC) concentration were measured between ground-level and 500m AGL over Milan. A tethered balloon was fitted with an instrumentation package consisting of the newly-developed micro-Aethalometer (microAeth® Model AE51, Magee Scientific, USA), an optical particle counter, and a portable meteorological station. At the same time, PM(2.5) samples were collected both at ground-level and at a high altitude sampling site, enabling particle chemical composition to be determined. Vertical profiles and PM(2.5) data were collected both within and above the mixing layer. Absorption coefficient (b(abs)) profiles were calculated from the Aethalometer data: in order to do so, an optical enhancement factor (C), accounting for multiple light-scattering within the filter of the new microAeth® Model AE51, was determined for the first time. The value of this parameter C (2.05±0.03 at λ=880nm) was calculated by comparing the Aethalometer attenuation coefficient and aerosol optical properties determined from OPC data along vertical profiles. Mie calculations were applied to the OPC number-size distribution data, and the aerosol refractive index was calculated using the effective medium approximation applied to aerosol chemical composition. The results compare well with AERONET data. The BC and b(abs) profiles showed a sharp decrease at the mixing height (MH), and fairly constant values of b(abs) and BC were found above the MH, representing 17±2% of those values measured within the mixing layer. The BC fraction of aerosol volume was found to be lower above the MH: 48±8% of the corresponding ground-level values. A statistical mean profile was calculated, both for BC and b(abs), to better describe their behaviour; the model enabled us to compute their average behaviour as a function of height, thus laying the foundations for valid parametrizations of vertical profile data which can be useful in both remote sensing
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[Manual handling of loads in the hotel trade: the experience of the ASL (Local Health Unit) Milan].
Fontani, S; Mercuri, Irene; Salicco, R; Veratti, Silvia; Sorrentino, L
2010-01-01
There are over 400 hotels in Milan with a guest capacity of about 62,000 and employing more than 10,000 workers. In 2008/09 the Occupational Health and Safety Service of A.S.L. Milano (Local Health Unit) carried out research into the hotel trade to ascertain the development of this commercial sector, also in view of EXPO 2015. The aim of the project was to improve hygiene and safety conditions and carry out preventive measures. A specific purpose was to study manual handling of loads and repetitive movements risk. The study covered 30 hotels and 7 temporary staff cooperatives. We acquired the Risk Evaluation Document, the Health Surveillance Programme and Registers of Labour Accidents to analyze manual handling of loads and repetitive movements. In the investigations and assessments on hotels we used currently available scientific tools--NIOSH Lifting Index, Push and Pulling Analysis, OC.R.A. Check-List--to study risks related to handling loads and upper limb mechanical overload, which revealed a specific occupational risk that requires a fresh approach to prevention and safety in the entire sector. Chambermaid: LI (Range): 0.57-2.75; Push and Pulling Actions: Fi 0.66-Fm 1.5 and Fi 0.76-Fm 1.33 respectively; OC.R.A. Check-List: 21. Porter: LI (Range): 0.77-3.75. Maintenance staff LI (Range): 0.57-2.75. The study highlighted the presence of risk due to manual handling of loads and repetitive movements in porters, maintenance personnel and particularly in chambermaids that up to now have been poorly assessed by safety experts. Analysis of the information contained in the registers of labour accidents suggests that a significant number of accidents can be related to muscular-skeletal disorders that affect especially cleaning, portering and kitchen staff
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Directory of Open Access Journals (Sweden)
Giovanni Zambon
2016-10-01
Full Text Available Il questa memoria sono riportati i primi risultati del progetto Dynamap relativi all’area pilota di Milano. Il progetto sviluppa un approccio alla rappresentazione del rumore derivante da traffico stradale che consenta una mappatura acustica dinamica attraverso la scalatura di mappe precalcolate mediante un collegamento diretto con un numero limitato di stazioni di monitoraggio. La possibilità di controllare la mappa acustica di una rete stradale estesa mediante pochi punti di controllo si attua mediante una necessaria aggregazione degli archi stradali in gruppi omogenei. ------ This memory reports the first results of Dynamap project related to the Milan pilot area. The project develops an approach to represent road traffic noise with the outcome of a dynamic noise mapping achieved through the scaling of precalculated maps; scaling is based upon a direct connection to a limited number of noise monitoring stations. The possibility of controlling the acoustic map of an extended road network by means of a few monitoring sites is implemented through a preliminary aggregation of road stretches into homogeneous groups.
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Energy Technology Data Exchange (ETDEWEB)
Fontaras, Georgios, E-mail: georgios.fontaras@jrc.ec.europa.eu [Institute for Energy and Transport, Joint Research Centre, Ispra (Italy); Martini, Giorgio; Manfredi, Urbano; Marotta, Alessandro; Krasenbrink, Alois [Institute for Energy and Transport, Joint Research Centre, Ispra (Italy); Maffioletti, Francesco; Terenghi, Roberto; Colombo, Mauro [AMSA, Azienda Milanese Servizi Ambientali, Milano (Italy)
2012-06-01
This paper summarizes the results of an extensive experimental study aiming to evaluate the performance and pollutant emissions of diesel and CNG waste collection trucks under realistic and controlled operating conditions in order to support a fleet renewal initiative in the city of Milan. Four vehicles (1 diesel and 3 CNG) were tested in two phases using a portable emission measurement system. The first phase included real world operation in the city of Milan while the second involved controlled conditions in a closed track. Emissions recorded from the diesel truck were on average 2.4 kg/km for CO{sub 2}, 0.21 g/km for HC, 7.4 g/km for CO, 32.3 g/km for NO{sub x} and 46.4 mg/km for PM. For the CNG the values were 3.6 kg/km for CO{sub 2}, 2.19 g/km for HC, 15.8 g/km for CO, 4.38 g/km for NO{sub x} and 11.4 mg/km for PM. CNG vehicles presented an important advantage with regards to NO{sub x} and PM emissions but lack the efficiency of their diesel counterparts when it comes to CO, HC and particularly greenhouse gas emissions. This tradeoff needs to be carefully analyzed prior to deciding if a fleet should be shifted towards either technology. In addition it was shown that existing emission factors, used in Europe for environmental assessment studies, reflect well the operation for CNG but were not so accurate when it came to the diesel engine truck particularly for CO{sub 2} and NO{sub x}. With regard to NO{sub x}, it was also shown that the limits imposed by current emission standards are not necessarily reflected in real world operation, under which the diesel vehicle presented almost 4 times higher emissions. Regarding CO{sub 2}, appropriate use of PEMS data and vehicle information allows for accurate emission monitoring through computer simulation. - Highlights: Black-Right-Pointing-Pointer Investigated diesel and CNG Euro V waste collection vehicles for municipal use Black-Right-Pointing-Pointer NO{sub x}-GhG emission trade-off should be considered prior to
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The fate of the postmodern world: On melancholy and rebellion by Milan Mihajlović
Directory of Open Access Journals (Sweden)
Vuksanović Ivana
2016-01-01
Full Text Available The musical oeuvre of Milan Mihajlović (b. 1945 enjoys a high reputation and position in contemporary Serbian music. This has been proven by the many awards he has received, countless performances of his compositions at home and abroad, and especially by the warm and approving reactions of the audience. The stylistic consistency in his oeuvre is a result of his creative use of Scriabin’s scale. The concept of this scale was first theoretically elaborated in an extensive study written by Mihajlović in 1980 and, since then the scale has been functioning as a crucial cohesive element in all Mihajlović’s compositions. The novelty in his oeuvre, composed during the 1990s, were intertextual references made by using citations from his own works and those of other composers (Monteverdi, Mozart, Stravinsky, Rachmaninov, Vasilije Mokranjac. The most characteristic features of his mature style are also recognizable in his recent works Melancholy (2014 and Rebellion (2015. The interval structure of Skriabin’s scale is projected along the horizontal (melodical and vertical (harmonical axes of the both works while the formal design resulted from shifts of tensions and relaxations. Developmental sections are based on variation and improvisation of the small number of different motifs (three basic ones in Melancholy, four in Rebellion above the metrically moveable ostinato layers and the releases are marked by change of tempo, dynamic, meter and texture. The most significant and radical release is the one which marks the abrupt ending of Rebellion by the physical gesture of slamming down the keyboard lid. As the composition was written for the BUNT festival (Belgrade it fits the festival’s idea of expressing resistance to the government’s neglect of academic musicians and institutions. In the wider sense, it becomes a sign of the resistance to the world we live in, and that is the world of lost ideals. Both works are composed for the wind
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Source Hierarchy List. Volume 2. E through N
1994-07-01
OEPT OE FISIOLOGIA 02 UNIVERSIDAD COMPLL- -i <SE DE MADRID (SPAIN) OEPT DE fcsf^.URGIA 02 UNIVERSIDAD COMPLUTENSE DE MADRID (SPAIN) FACULTAD...MILAN UNIV (ITALY) ISTITUTO DI FISIOLOGIA UMANA 01 MILAN UNIV (ITALY) ISTITUTO DI PATOLOGIA MEOICA 01 MILAN UNIV UTALY) ISTITUTO DI SCIENZE
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Oreni, D.; Karimi, G.; Barazzetti, L.
2017-08-01
This paper presents the development of a BIM model for a stratified historic structure characterized by a complex geometry: Filarete's Ospedale Maggiore ice house, one of the few remaining historic ice houses in Milan (Fig. 1). Filarete, a well-known Renaissance architect and theorist, planned the hospital in the 15th century, but the ice house was built two centuries later with a double-storey irregular octagonal brick structure, half under and half above ground, that enclosed another circular structure called the ice room. The purpose of the double-walled structure was to store ice in the middle and store and preserve perishable food and medicine at the outer side of the ice room. During World War II, major portions of the hospital and the above-ground section of the ice house was bombed and heavily damaged. Later, in 1962, the hospital was restored and rehabilitated into a university, with the plan to conceal the ice house's remaining structure in the courtyard, which ultimately was excavated and incorporated into a new library for the university. A team of engineers, architects, and students from Politecnico di Milano and Carleton University conducted two heritage recording surveys in 2015 and 2016 to fully document the existing condition of the ice house, resulting in an inclusive laser scanner and photogrammetric point cloud dataset. The point cloud data was consolidated and imported into two leading parametric modelling software, Autodesk Revitand Graphisoft ArchiCAD©, with the goal to develop two BIMs in parallel in order to study and compare the software BIM workflow, parametric capabilities, attributes to capture the complex geometry with high accuracy, and the duration for parametric modelling. The comparison study of the two software revealed their workflow limitations, leading to integration of the BIM generative process with other pure modelling software such as Rhinoceros©. The integrative BIM process led to the production of a comprehensive BIM
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Directory of Open Access Journals (Sweden)
C. Stanga
2017-08-01
Full Text Available This essay describes the combination of 3D solutions and software techniques with traditional studies and researches in order to achieve an integrated digital documentation between performed surveys, collected data, and historical research. The approach of this study is based on the comparison of survey data with historical research, and interpretations deduced from a data cross-check between the two mentioned sources. The case study is the Basilica of S. Ambrogio in Milan, one of the greatest monuments in the city, a pillar of the Christianity and of the History of Architecture. It is characterized by a complex stratification of phases of restoration and transformation. Rediscovering the great richness of the traditional architectural notebook, which collected surveys and data, this research aims to realize a virtual notebook, based on a 3D model that supports the dissemination of the collected information. It can potentially be understandable and accessible by anyone through the development of a mobile app. The 3D model was used to explore the different historical phases, starting from the recent layers to the oldest ones, through a virtual subtraction process, following the methods of Archaeology of Architecture. Its components can be imported into parametric software and recognized both in their morphological and typological aspects. It is based on the concept of LoD and ReverseLoD in order to fit the accuracy required by each step of the research.
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Stanga, C.; Spinelli, C.; Brumana, R.; Oreni, D.; Valente, R.; Banfi, F.
2017-08-01
This essay describes the combination of 3D solutions and software techniques with traditional studies and researches in order to achieve an integrated digital documentation between performed surveys, collected data, and historical research. The approach of this study is based on the comparison of survey data with historical research, and interpretations deduced from a data cross-check between the two mentioned sources. The case study is the Basilica of S. Ambrogio in Milan, one of the greatest monuments in the city, a pillar of the Christianity and of the History of Architecture. It is characterized by a complex stratification of phases of restoration and transformation. Rediscovering the great richness of the traditional architectural notebook, which collected surveys and data, this research aims to realize a virtual notebook, based on a 3D model that supports the dissemination of the collected information. It can potentially be understandable and accessible by anyone through the development of a mobile app. The 3D model was used to explore the different historical phases, starting from the recent layers to the oldest ones, through a virtual subtraction process, following the methods of Archaeology of Architecture. Its components can be imported into parametric software and recognized both in their morphological and typological aspects. It is based on the concept of LoD and ReverseLoD in order to fit the accuracy required by each step of the research.
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Directory of Open Access Journals (Sweden)
L. Ferrero
2010-04-01
Full Text Available Vertical aerosol profiles were directly measured over the city of Milan during three years (2005–2008 of field campaigns. An optical particle counter, a portable meteorological station and a miniaturized cascade impactor were deployed on a tethered balloon. More than 300 vertical profiles were measured, both in winter and summer, mainly in conditions of clear, dry skies.
The mixing height was determined from the observed vertical aerosol concentration gradient, and from potential temperature and relative humidity profiles. Results show that inter-consistent mixing heights can be retrieved highlighting good correlations between particle dispersion in the atmosphere and meteorological parameters. Mixing height growth speed was calculated for both winter and summer showing the low potential atmospheric dispersion in winter.
Aerosol number size distribution and chemical composition profiles allowed us to investigate particle behaviour along height. Aerosol measurements showed changes in size distribution according to mixing height. Coarse particle profiles (dp>1.6 μm were distributed differently than the fine ones (dp<1.6 μm were, at different heights of the mixing layer. The sedimentation process influenced the coarse particle profiles, and led to a reduction in mean particle diameter for those particles observed by comparing data above the mixing height with ground data (−14.9±0.6% in winter and −10.7±1.0% in summer. Conversely, the mean particle diameter of fine particles increased above the mixing height under stable atmospheric conditions; the average increase, observed by comparing data above the mixing height with ground data, was +2.1±0.1% in winter and +3.9±0.3% in summer. A hierarchical statistical model was created to describe the changes in the size distribution of fine particles along height. The proposed model can be used to estimate the typical vertical -
Directory of Open Access Journals (Sweden)
Serena Falasca
2018-02-01
Full Text Available The Urban Heat Island (UHI is a well-known phenomenon concerning an increasing percentage of the world’s population due to the growth rates of metropolitan areas. Given the health and economic implications of UHIs, several mitigation techniques are being evaluated and tested. In this study, we consider the use of highly reflective materials for urban surfaces, and we carried out numerical experiments using the Weather Research and Forecasting model coupled with the CHIMERE model in order to investigate the effects of these materials on the meteorology and air quality in the urban area of Milan (Italy. Results show that an increase in albedo from 0.2 to 0.7 for urban roofs, walls and streets leads to a decrease in UHI intensity by up to 2–3 °C and of the planetary boundary layer (PBL height of about 500 m. However, the difference of PM10 and ozone between urban and surrounding areas increases by a factor of about 2, attributable to the reduction of PBL height and wind speed and to the increased reflected solar radiation that may enhance photochemical production during the daytime. Therefore, if anthropogenic emissions are held at the same levels, the potential benefit to the UHI in terms of thermal discomfort may have negative repercussions on air quality.
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Menon, K V; Hakeem, A R; Heaton, N D
2014-10-01
Liver transplantation (LT) plays an important role in the management of patients with hepatocellular carcinoma (HCC). Although early results following LT for HCC were poor, since the introduction of the Milan criteria in 1996 morphological criteria have since been well established. Thereafter, various expansions of the Milan criteria were introduced worldwide. Listing criteria for LT for HCC in the United Kingdom (UK) initially conformed to the Milan criteria but were re-defined in 2009 by expansion of the Milan criteria. To look at the evidence in literature on listing criteria and management of HCC worldwide in comparison with the UK. Secondly, we aim to review worldwide vs. UK literature on prioritisation models, loco-regional therapy protocols and role of alpha-fetoprotein (AFP) in LT for HCC. An electronic literature search with Medline was carried out to identify articles related to LT for HCC. Although various expansions of the Milan criteria have been described, they remain the gold standard against which other criteria are measured. The UK criteria are an expansion of the Milan criteria that go beyond Milan and University of California, San Francisco (UCSF) criteria. The current UK listing criteria for LT for HCC when compared to the worldwide criteria have a worse survival benefit (projected 5-year survival between 35-50%) when plotted on the metroticket calculator. In keeping with most transplant centres worldwide, the UK have adopted expansions to Milan to allow more patients to benefit from LT. However, currently, as it stands the UK criteria when plotted in the modification of the Metroticket model project worse survival that would seem unjustified. © 2014 John Wiley & Sons Ltd.
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Boscovich and the Brera Observatory .
Antonello, E.
In the mid 18th century both theoretical and practical astronomy were cultivated in Milan by Barnabites and Jesuits. In 1763 Boscovich was appointed to the chair of mathematics of the University of Pavia in the Duchy of Milan, and the following year he designed an observatory for the Jesuit Collegium of Brera in Milan. The Specola was built in 1765 and it became quickly one of the main european observatories. We discuss the relation between Boscovich and Brera in the framework of a short biography. An account is given of the initial research activity in the Specola, of the departure of Boscovich from Milan in 1773 and his coming back just before his death.
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International Nuclear Information System (INIS)
Perujo, Adolfo; Ciuffo, Biagio
2010-01-01
The study analyses the possible impact of the electric vehicles' recharging activities on the electric supply system for the Province of Milan and on the global environment with a 2030 time horizon. In particular, the impact on the electric grid is seen both in terms of total electric energy consumption and in power requested to the grid. Because of the long recharging time required by the car batteries, the probability to have thousands of cars contemporary plugged-in at a given time is not negligible. On the other hand, the impact on the environment is seen in terms of CO 2 emissions reduction. Even if, at the moment, the Italian electric energy mix is mainly generated by means of thermal power stations making use of not renewable fossil fuels, the efficiency of these plants is much higher than the efficiency of a vehicle's engine. Results obtained clearly show that electric vehicles can contribute to the overall CO 2 abatement strategy in the transport sector but at the same time without an appropriate regulation (e.g. the intelligent integration of electric vehicles into the existing power grid as decentralised and flexible energy storage asset), electric vehicles could heavily impact on the daily requested electric power.
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Directory of Open Access Journals (Sweden)
D. Oreni
2017-08-01
Full Text Available This paper presents the development of a BIM model for a stratified historic structure characterized by a complex geometry: Filarete’s Ospedale Maggiore ice house, one of the few remaining historic ice houses in Milan (Fig. 1. Filarete, a well-known Renaissance architect and theorist, planned the hospital in the 15th century, but the ice house was built two centuries later with a double-storey irregular octagonal brick structure, half under and half above ground, that enclosed another circular structure called the ice room. The purpose of the double-walled structure was to store ice in the middle and store and preserve perishable food and medicine at the outer side of the ice room. During World War II, major portions of the hospital and the above-ground section of the ice house was bombed and heavily damaged. Later, in 1962, the hospital was restored and rehabilitated into a university, with the plan to conceal the ice house’s remaining structure in the courtyard, which ultimately was excavated and incorporated into a new library for the university. A team of engineers, architects, and students from Politecnico di Milano and Carleton University conducted two heritage recording surveys in 2015 and 2016 to fully document the existing condition of the ice house, resulting in an inclusive laser scanner and photogrammetric point cloud dataset. The point cloud data was consolidated and imported into two leading parametric modelling software, Autodesk Revit© and Graphisoft ArchiCAD©, with the goal to develop two BIMs in parallel in order to study and compare the software BIM workflow, parametric capabilities, attributes to capture the complex geometry with high accuracy, and the duration for parametric modelling. The comparison study of the two software revealed their workflow limitations, leading to integration of the BIM generative process with other pure modelling software such as Rhinoceros©. The integrative BIM process led to the production
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Directory of Open Access Journals (Sweden)
Lisa Lucia Chenal
2011-06-01
Full Text Available In the spring of 2009, a new variant of influenza A/H1N1 virus that had never been isolated before, was identified. From April 27 to December 31, 2009 the respiratory samples of 974 patients, obtained from suspected cases of pandemic influenza A virus infection, were analyzed at the Clinical Microbiology Laboratory of the “L. Sacco” University Hospital in Milan. The diagnosis of influenza A/H1N1 infection was performed initially through the use of different molecular biological methods: Seeplex® RV12 ACE Detection (Seegene, NUCLISENS® EASYQ® INFLUENZA A/B (bioMérieux, Influenza A/B Q-PCR Alert (Nanogen running in parallel with rRT-PCR (CDC to confirm the positivity to the new influenza virus, then was used a single specific test, Fast set H1N1v (Arrow Diagnostics. Retrospective study of data showed that 293 (30.1% patients were positive for the new strain of influenza A/H1N1 virus and 8 (0.8% for influenza A other than H1N1 virus.The distribution of influenza A/H1N1 cases showed two peaks, one on July (62.9% and the other one on October (36%, moreover we observed that 155 patients (53% out of 293 positive for influenza A/H1N1 virus aged under 20 years old. The first positivity peak was found in travelers and the second one, occurred 2-3 months prior to the classic seasonal epidemic influenza, was attributed to autochthonous cases , by which the virus had spread worldwide. The highest proportion of cases were among subjects aged from 0 to 20 years and, over this age the positivity rate decreased proportionally with increasing age, in agreement with data reported in other countries.
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Directory of Open Access Journals (Sweden)
Elena Casotto
2013-11-01
due città ha delle ripercussioni anche sul linguaggio artistico dei veronesi, il quale si differenzia dalla restante arte veneta – in massima parte influenzata dalla tradizione veneziana – proprio per una certa affinità con la pittura lombarda. The study aims to illustrate (when it is possible also through artists’ writings the stories of the Verona’s painters who, in the nineteenth century, seek their fortune in Milan, which was the most updated artistic center in North Italy, especially beaucase of its Academy and its frequented exhibitions. This "migration" occurs because, during the Hapsburg’s rule (1815 - 1866, Verona becomes the pivot of the military system of the Regno Lombardo - Veneto and, consequently, the development of the city is subordinated to the needs of the military companies that stay or transit through its territory. Therefore military buildings and the means for long distance communications are increased, but the development of the city and the creation of small industries and businesses, that can help Verona’s people, are disregarded. In this situation, the art market is slack, both for the lack of public and private buyers, and for the few exhibitions organized during these difficult years. Also the Verona’s Academy experiences hard tiemes, due to outdated teaching methods and to the lack of money: in this situation the quality of teaching gets worse, so the artists, who have studied at this school, are unprepared to compete with painters coming from other italian Academies. After the unification of Italy and especially after the reform of the School of fine art of Verona (1873, the relationship between Verona and Milan becomes more complex: not only Verona’s painters go to Milan for studing and exhibiting their works of art, but also the authors from Lombardia do not disdain the shows of the Venetian city and even they aim at the direction of Verona’s Academy. Finally, it should be noted that the link between the two
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Surface modification of RuO2 electrodes by laser irradiation and ion ...
Indian Academy of Sciences (India)
Administrator
Indian Academy of Sciences. 639. †. Dedicated to the ... Department of Physical Chemistry and Electrochemistry, University of Milan,. Via Venezian 21, 20133 Milan, ..... Soc. 129 1689. 21. Parsons R 1961 In Advances in electrochemistry and.
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Decaens, Thomas; Roudot-Thoraval, Françoise; Hadni-Bresson, Solange; Meyer, Carole; Gugenheim, Jean; Durand, Francois; Bernard, Pierre-Henri; Boillot, Olivier; Sulpice, Laurent; Calmus, Yvon; Hardwigsen, Jean; Ducerf, Christian; Pageaux, Georges-Philippe; Dharancy, Sebastien; Chazouilleres, Olivier; Cherqui, Daniel; Duvoux, Christophe
2006-12-01
Orthotopic liver transplantation (OLT) indication for hepatocellular carcinoma (HCC) is currently based on the Milan criteria. The University of California, San Francisco (UCSF) recently proposed an expansion of the selection criteria according to tumors characteristics on the explanted liver. This study: 1) assessed the validity of these criteria in an independent large series and 2) tested for the usefulness of these criteria when applied to pre-OLT tumor evaluation. Between 1985 and 1998, 479 patients were listed for liver transplantation (LT) for HCC and 467 were transplanted. According to pre-OLT (imaging at date of listing) or post-OLT (explanted liver) tumor characteristics, patients were retrospectively classified according to both the Milan and UCSF criteria. The 5-yr survival statistics were assessed by the Kaplan-Meier method and compared by the log-rank test. Pre-OLT UCSF criteria were analyzed according to an intention-to-treat principle. Based on the pre-OLT evaluation, 279 patients were Milan+, 44 patients were UCSF+ but Milan- (subgroup of patients that might benefit from the expansion), and 145 patients were UCSF- and Milan-. With a short median waiting time of 4 months, 5-yr survival was 60.1 +/- 3.0%, 45.6 +/- 7.8%, and 34.7 +/- 4.0%, respectively (P OLT evaluation, the UCSF criteria are associated with a 5-yr survival below 50%. Their applicability is therefore limited, despite similar survival rates compared to the Milan criteria, when the explanted liver is taken into account.
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Antimicrobial Synergic Effect of Allicin and Silver Nanoparticles on ...
African Journals Online (AJOL)
Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran, 4Department of ... Milan State University, Via G. Celoria 2, 20133, Milan, Italy .... on solid nutrient agar by making streaks on the surface of .... personnel in a Burn center.
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Petit, Jean Yves; Lohsiriwat, Visnu; Clough, Krishna B; Sarfati, Isabelle; Ihrai, Tarik; Rietjens, Mario; Veronesi, Paolo; Rossetto, Fabio; Scevola, Anna; Delay, Emmanuel
2011-08-01
Lipofilling is now performed to improve the breast contour, after both breast-conserving surgery and breast reconstruction. However, injection of fat into a previous tumor site may create a new environment for cancer and adjacent cells. There is also no international agreement regarding lipofilling after breast cancer treatment. The authors included three institutions specializing in both breast cancer treatment and breast reconstruction (European Institute of Oncology, Milan, Italy; Paris Breast Center, Paris, France; and Leon Berard Centre, Lyon, France) for a multicenter study. A collective chart review of all lipofilling procedures after breast cancer treatment was performed. From 2000 to 2010, the authors reviewed 646 lipofilling procedures from 513 patients. There were 370 mastectomy patients and 143 breast-conserving surgery patients. There were 405 patients (78.9 percent) with invasive carcinoma and 108 (21.1 percent) with carcinoma in situ. The average interval between oncologic surgical interventions and lipofilling was 39.7 months. Average follow-up after lipofilling was 19.2 months. The authors observed a complication rate of 2.8 percent (liponecrosis, 2.0 percent). Twelve radiologic images appeared after lipofilling in 119 breast-conserving surgery cases (10.1 percent). The overall oncologic event rate was 5.6 percent (3.6 percent per year). The locoregional event rate was 2.4 percent (1.5 percent per year). Lipofilling after breast cancer treatment leads to a low complication rate and does not affect radiologic follow-up after breast-conserving surgery. A prospective clinical registry including high-volume multicenter data with a long follow-up is warranted to demonstrate the oncologic safety. Until then, lipofilling should be performed in experienced hands, and a cautious oncologic follow-up protocol is advised. Therapeutic, IV [corrected].
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Toniolo, L.; Gulotta, D.; Bertoldi, M.; Bortolotto, S.
2012-04-01
The Richini courtyard is a masterpiece of northern Italy baroque and it is part of the complex that currently hosts the "Università degli Studi" of Milan. Its four internal façades are based on a double arcade structure with granitic columns along a rectangular plan. The architectural elements are enriched by an outstanding sculpted decoration made of Angera stone (a typical Lombard dolostone) with bas-relief panels, high-relief figures, mouldings and voussoirs. The courtyard suffers the consequences of a troubled conservation history: the Second World War bombardment caused devastating damages to both the structure and the sculpted surfaces, so that an extensive restoration was carried out during the early fifties. Moreover, a further and massive conservative intervention was required during the nineties due to the increasing degradation rate of the Angera stone subjected to severely polluted environmental conditions. The overall durability of this last intervention, as well as the long-term compatibility of the restoration materials, has been evaluated almost twenty years later, in 2011. A thorough study of representative areas of the courtyard has been conducted by a multi-disciplinary research group. The aim of the study was the evaluation of the state of conservation of the ancient and restoration materials, as well as the identification of the decay phenomena. A high-accurate 3D laser scanner survey of the courtyard has been performed as well. The results of the diagnostic activity has been summarised in the present work. The wide range of different type of data (analytical and geometrical data, historical records, photographic documentation) have been managed by the latest release of a web-GIS software specifically designed for the application in the built heritage conservation. A new data structure has been purposely designed in order to maximize the efficiency for what concerning data entry, data query and data updating. The enhanced web-GIS software has
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Directory of Open Access Journals (Sweden)
Mathias Balbi
2014-05-01
Full Text Available Our contribution concentrates on the processes of cataloguing and digitising of hand–written letters and business documents belonging to the ''Ricordi Historical Archive'' in Milan, which is at present housed in the Braidense National Library; the archive possesses documents referring to the history of the publishing company covering the two centuries of its activities. Starting from the ledgers compiled by Giovanni Ricordi, which cover a period from 1814 up to the middle of the 19th century to the documents relative to the school of engraving, the archive also houses a large number of editorial catalogues, published by Ricordi and by other publishing houses which it took over, as well as the original contracts stipulated with composers and librettists from Giuseppe Verdi and Giacomo Puccini to Arrigo Boito. The collection of about 15,000 hand–written letters covers the period from the beginning of the 19th century to the end of the 20th century and includes documents sent to Ricordi from writers, singers authors, and composers such as Giuseppe Verdi, Giacomo Puccini and Ottorino Respighi and librettists Luigi Illica, Giuseppe Giacosa and Arrigo Boito. The second part of the correspondence is made up letter–books and business correspondence which were kept intact from 1888 to 1962, except for the period from 1944 to 1953. Since 2006, work has been carried out to catalogue and digitise the Ricordi Archive based on the standards set out by the National Library Service (Servizio Bibliotecario Nazionale – SBN which is head of the Central Institute for the Single Catalogue (ICCU. The structure and use of the archive and the external transmission of its contents are safeguarded and enhanced thanks to the combined work of cataloguing and digitisation of this heritage: the preliminary cataloguing of the documents uses a simplified model of the scheme adopted in the description of the manuscript according to sw Manus, elaborated by ICCU: the
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Morandi, Antonio; Tosto, Carmen; Sartori, Guido; Roberti di Sarsina, Paolo
2011-01-01
The First International Congress on Ayurveda was held in Milan, Italy in March 2009 and it has been the first scientific event of this kind in western world. This groundbreaking international congress was devoted to human being as the product of interactions between Awareness, Environment and Health, subjects that the West tends to consider separate and independent, but that are believed deeply connected in Ayurveda, whose interdependence defines “The Meaning of Life”. The Congress established a bridge between indian and western philosophy, scientific and biomedical thinking in order to expand knowledge and healthcare. Main attention and address of the invited speakers was on the concept of “relationships” that, connecting living beings with environment, shape Nature itself. This concept is central in Ayurveda but is also common to other western scientific disciplines such as quantum physics and epigenetics that, in the four Sessions of the Congress, were represented by eminent experts. The importance of this event was underlined by the attendance of more than 400 participants and by noteworthy institutional endorsements, that added a significative political dimension of high social impact due to the topical period for CAM acceptance and integration in Europe. PMID:20981327
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Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Journal of Chemical Sciences. Milan Kanti Naskar. Articles written in Journal of Chemical Sciences. Volume 120 Issue 1 January 2008 pp 181-186. Significant improvement in the pore properties of SBA-15 brought about by carboxylic acids and hydrothermal treatment · Milan Kanti Naskar M ...
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Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Author Affiliations. Carmem L P S Zanta1 C A Martínez-Huitle2. Departamento de Química da Universidade Federal de Alagoas, Campus A.C. Simões, Tabuleiro do Martins, Maceió-AL 57072-970, Brazil; University of Milan, Department of Chemistry, Celoria 2, 20133 Milan, Italy ...
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Energy Technology Data Exchange (ETDEWEB)
Gualtieri, Maurizio [Applied Cell Biology and Particles Effects, Department of Environmental Science, University Milano-Bicocca, Piazza della Scienza 1, 20126 Milano (Italy); Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo (Norway); Ovrevik, Johan [Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo (Norway); Mollerup, Steen [Section for Toxicology, National Institute of Occupational Health, N-0033 Oslo (Norway); Asare, Nana [Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo (Norway); Longhin, Eleonora [Applied Cell Biology and Particles Effects, Department of Environmental Science, University Milano-Bicocca, Piazza della Scienza 1, 20126 Milano (Italy); Dahlman, Hans-Jorgen [Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo (Norway); Camatini, Marina [Applied Cell Biology and Particles Effects, Department of Environmental Science, University Milano-Bicocca, Piazza della Scienza 1, 20126 Milano (Italy); Centre Research POLARIS, Department of Environmental Science, University Milano-Bicocca, Piazza della Scienza 1, 20126 Milano (Italy); Holme, Jorn A., E-mail: jorn.holme@fhi.no [Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo (Norway)
2011-08-01
Highlights: {yields} PM2.5 induces mitotic arrest in BEAS-2B cells. {yields} PM2.5 induces DNA damage and activates DNA damage response. {yields} AhR regulated genes (Cyp1A1, Cyp1B1 and AhRR) are upregulated after PM exposure. {yields} Mitotic spindle assembly is perturbed in PM exposed cells. - Abstract: Airborne particulate matter (PM) is considered to be an important contributor to lung diseases. In the present study we report that Milan winter-PM2.5 inhibited proliferation in human bronchial epithelial cells (BEAS-2B) by inducing mitotic arrest. The cell cycle arrest was followed by an increase in mitotic-apoptotic cells, mitotic slippage and finally an increase in 'classical' apoptotic cells. Exposure to winter-PM10 induced only a slight effect which may be due to the presence of PM2.5 in this fraction while pure combustion particles failed to disturb mitosis. Fewer cells expressing the mitosis marker phospho-histone H3 compared to cells with condensed chromosomes, suggest that PM2.5 induced premature mitosis. PM2.5 was internalized into the cells and often localized in laminar organelles, although particles without apparent plasma membrane covering were also seen. In PM-containing cells mitochondria and lysosomes were often damaged, and in mitotic cells fragmented chromosomes often appeared. PM2.5 induced DNA strands breaks and triggered a DNA-damage response characterized by increased phosphorylation of ATM, Chk2 and H2AX; as well as induced a marked increase in expression of the aryl hydrocarbon receptor (AhR)-regulated genes, CYP1A1, CYP1B1 and AhRR. Furthermore, some disturbance of the organization of microtubules was indicated. It is hypothesized that the induced mitotic arrest and following cell death was due to a premature chromosome condensation caused by a combination of DNA, mitochondrial and spindle damage.
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Accessorizing, italian style: creating a market for Milan’s fashion merchandise
Merlo, Elisabetta; Polese, Francesca
2008-01-01
The chapter investigates the early development of the Italian fashion industry by considering the specific case of Milan at the end of the 19th century. It analyzes the emergence of a market for accessories in Milan, drawing on mail-order catalogues published by the Grandi Magazzini "Alle città d'Italia" in the 1880s
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Ferrari, Davide; Manca, Monica; Banfi, Giuseppe; Locatelli, Massimo
2018-01-01
Driving under the influence of alcohol and/or illicit drugs in Italy is regulated by the articles 186 and 187 of the National Street Code. Epidemiological studies on drivers involved in road traffic crashes (RTC) provide useful information about the use/abuse of these substances in the general population. Comparison with case control studies may reveal important information like the cut-off limits adequacy. Data from 1587 blood tests for alcohol and 1258 blood tests for illicit drugs on drivers involved in RTC around Milan between 2012 and 2016, were analyzed and compared with a published random survey (DRUID) from the European Community. Our data from RTC-involved drivers show that alcohol abuse is not age-related whereas illicit drugs are more common in young people. Cannabinoids are frequent among younger drivers (median age 27) whereas cocaine is more often detected in adults (median age 34). The calculated odds ratio after comparison with the DRUID survey shows that a blood alcohol concentration below the legal limit does not represent a risk factor in having a car accident whereas concentrations of cocaine and cannabinoids within the legal limits are associated with being involved in a car accident. Despite authority efforts, the abuse of alcohol and illicit drugs is still common in young drivers. We suspect that the cut-off limits for cannabinoids and cocaine and/or the pre-analytical procedures for these substances are inadequate. We suggest a better standardization of the procedure by shortening the time interval between the request for investigation and blood collection and propose the adoption of more stringent cut-off limits. Copyright © 2017 Elsevier B.V. All rights reserved.
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Directory of Open Access Journals (Sweden)
Santus P
2015-09-01
Full Text Available Pierachille Santus,1,2 Dejan Radovanovic,1,2 Silvia Di Marco,3 Vincenzo Valenti,4,5 Rita Raccanelli,1,2 Francesco Blasi,6,7 Stefano Centanni,8,9 Maurizio Bussotti31Department of Health Sciences, University of Milan, 2Pulmonary Rehabilitation Unit, Fondazione Salvatore Maugeri Scientific Institute of Milan-IRCCS, 3Cardiological Rehabilitation Unit, Fondazione Salvatore Maugeri Rehabilitation Institute of Milan-IRCCS, 4Department of Biomedical Sciences for Health, University of Milan, 5Respiratory Unit, Policlinico San Donato-IRCCS, San Donato Milanese, 6Department of Pathophysiology and Transplantation, University of Milan, 7IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milan, 8Department of Health Sciences, University of Milan, 9Respiratory Unit, Ospedale San Paolo, Milan, ItalyBackground: COPD is often associated with cardiovascular comorbidity. Treatment guidelines recommend therapy with bronchodilators as first choice. We investigated the acute effect of single-dose indacaterol on lung hyperinflation in COPD subjects, for the first time evaluating the potential effects on right heart performance.Methods: In this Phase IV, randomized, interventional, double-blind, crossover clinical study, we recruited 40 patients (50–85 years of age with stable COPD. Patients were treated with 150 µg indacaterol or placebo and after 60 minutes (T60 and 180 minutes (T180 the following tests were performed: trans-thoracic echocardiography (TTE, plethysmography, diffusing capacity of the lung for carbon monoxide, saturation of peripheral oxygen, and visual analog scale dyspnea score. Patients underwent a crossover re-challenge after a further 72 hours of pharmacological washout. All TTE measurements were conducted blindly by the same operator and further interpreted by two different blinded operators. Consensus decisions were taken on every value and parameter. The primary outcome was the effect of the reduction of residual volume and functional
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Piros, L; Fehérvári, I; Görög, D; Nemes, B; Szabó, J; Gerlei, Z; Végső, G; Kóbori, L; Máthé, Z
2015-09-01
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Orthotopic liver transplantation (OLT) is the best therapy of choice for early, unresectable HCC. The Hungarian Liver Transplantation Program was launched in 1995 at the Department of Transplantation and Surgery, Semmelweis University, Budapest. From that time more than 60 patients underwent OLT for hepatic tumors, which in most cases were HCC. Our clinical examination was undertaken to analyze the possible influential factors of outcomes for our series of patients who received OLT for HCC. We performed a review of all patients who underwent OLT for HCC at our department from 1996 to October 1, 2013. Disease extent was determined by preoperative computed tomography or magnetic resonance images. All explants were examined and categorized based on tumor number, size, distribution, HCC histologic grade, and vascular invasion. Patients with HCC were classified as having tumors either meeting Milan criteria, beyond Milan criteria but within UCSF criteria, or exceeding UCSF criteria. OLT was performed using standard techniques including orthotopic implantation with cross-clamp technique or with the piggyback technique. Postoperative immunosuppression included a triple drug regimen of calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and prednisone. mTOR inhibitors have been available since 2004. HCC most commonly occurs in the presence of cirrhosis as a result of longstanding chronic liver disease. Most of our patients who underwent OLT for HCC are 56 to 60 years old, and most also had underlying HCV cirrhosis. As of October 1, 2013, 21 of 49 (42.85%) patients had died after OLT for HCC. The main cause was the recurrence of the HCC in 38%, followed by sepsis in 33%, and HCV recurrence in 19%. One death each (4.7% of the total number of deaths) was caused by primary nonfunction of the graft, acute myocardial infarct, and de novo malignancy, respectively. Overall
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LENUS (Irish Health Repository)
Qasim, A
2012-02-01
BACKGROUND: Hepatic transplantation outcomes for cirrhotic patients with hepatocellular carcinoma (HCC) at a small- to medium-volume centre are not fully known due to relative novelty of patient selection criteria. AIM: To determine hepatic transplantation outcomes for HCC at a small- to medium-volume centre. Patients and methods Hepatocellular carcinoma patients were listed for transplantation according to the International Guideline and further categorized as those fulfilling or exceeding Milan or University of San Francisco (UCSF) criteria on explanted liver morphology. Outcomes including mortality, retransplantation, and tumour recurrence rate were analysed. RESULTS: Twenty-six patients had HCC and on explanted liver morphology, Milan and UCSF criteria met 15 and 18 patients, respectively. Patients and graft survival at 3 months, 1 and 5 years were 100, 96, 84, and 88, 84, 77%, respectively. Outcomes favoured Milan criteria but did not reach statistical significance. CONCLUSIONS: Hepatic transplantation for HCC at a small-to medium-volume transplant centre had comparable survival outcomes to high-volume centres.
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2016-01-01
Guido Vegni, a renowned particle physicist and Professor at the University of Milan, passed away on Thursday, 2 June. Professor Guido Vegni in 1976, at the Institute for High Energy Physics in Protvino, Russia. Italian physicist Guido Vegni passed away on Thursday, 2 June. With his death we have lost a friend, an excellent physicist and a strong supporter of the CERN programme. His long and fruitful involvement in particle physics started in the mid 1950s, when he joined the Milan nuclear emulsion group led by Giuseppe Occhialini in 1956. His thesis aimed to measure the spin-parity assignment of the K+ meson from its decay into three pions, contributing to the study of the famous "tau-theta puzzle", eventually solved by the discovery of the non-conservation of parity in weak interactions. In 1960, Guido was appointed "Assistant" to Professor G. Occhialini in Milan, the first step of a career that led to him eventually becom...
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Club d'orientation
2013-01-01
Relais inter-club/Challenge Carlo Milan Samedi 28 septembre, à Apples-Ballens (Vd), a eu lieu le relais inter-club avec le Challenge Carlo Milan. 32 équipes étaient présentes pour défendre les couleurs de leur club, que se soit sur le relais technique avec trois coureurs ou sur le relais facile avec deux coureurs. La victoire du relais technique revenait à une équipe du CARE Vevey, quant au relais facile, la première place était pour le club Lausanne-Jorat. Le CO CERN avait à cœur de défendre le challenge Carlo Milan remporté l’an dernier mais il n’a pas pu résister au club du O’Jura, qui plaçait notamment quatre de ses équipes sur les six premières places du relais technique. Les rendez-vous de la coupe genevoise pour les deux prochaines semaines seront: - le vendredi 11 octobre aux Evaux pou...
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Ferrero, Luca; Casati, Marco; Nobili, Lara; D'Angelo, Luca; Rovelli, Grazia; Sangiorgi, Giorgia; Rizzi, Cristiana; Perrone, Maria Grazia; Sansonetti, Antonio; Conti, Claudia; Bolzacchini, Ezio; Bernardi, Elena; Vassura, Ivano
2018-04-01
The collection of atmospheric particles on not-filtering substrates via dry deposition, and the subsequent study of the particle-induced material decay, is trivial due to the high number of variables simultaneously acting on the investigated surface. This work reports seasonally resolved data of chemical composition and size distribution of particulate matter deposed on stone and surrogate surfaces obtained using a new method, especially developed at this purpose. A "Deposition Box" was designed allowing the particulate matter dry deposition to occur selectively removing, at the same time, variables that can mask the effect of airborne particles on material decay. A pitched roof avoided rainfall and wind variability; a standardised gentle air exchange rate ensured a continuous "sampling" of ambient air leaving unchanged the sampled particle size distribution and, at the same time, leaving quite calm condition inside the box, allowing the deposition to occur. Thus, the "Deposition Box" represents an affordable tool that can be used complementary to traditional exposure systems. With this system, several exposure campaigns, involving investigated stone materials (ISMs) (Carrara Marble, Botticino limestone, Noto calcarenite and Granite) and surrogate (Quartz, PTFE, and Aluminium) substrates, have been performed in two different sites placed in Milan (Italy) inside and outside the low emission zone. Deposition rates (30-90 μg cm -2 month -1 ) showed significant differences between sites and seasons, becoming less evident considering long-period exposures due to a positive feedback on the deposition induced by the deposited particles. Similarly, different stone substrates influenced the deposition rates too. The collected deposits have been observed with optical and scanning electron microscopes and analysed by ion chromatography. Ion deposition rates were similar in the two sites during winter, whereas it was greater outside the low emission zone during summer and
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Directory of Open Access Journals (Sweden)
Il Comitato di esperti antimafia del Comune di Milano
2016-11-01
Full Text Available La sezione “Il documento” propone due capitoli della Relazione conclusiva redatta dal “Comitato di esperti per lo studio e la promozione di attività finalizzate al contrasto dei fenomeni di stampo mafioso e della criminalità organizzata sul territorio milanese, anche in vista della manifestazione Expo Milano 2015”, consegnata il 28 ottobre 2016 all’ex Sindaco di Milano Giuliano Pisapia e all’attuale Sindaco Giuseppe Sala. Gli estratti qui proposti riguardano le infiltrazioni mafiose in Expo e la presenza mafiosa a Milano. Parole chiave: Comitato di esperti; Expo 2015; Milano; ‘ndrangheta; appalti The section ‘The Document” offers two chapters of the last report issued by the Antimafia Committee of the City Council of Milan (Comitato di esperti per lo studio e la promozione di attività finalizzate al contrasto dei fenomeni di stampo mafioso e della criminalità organizzata sul territorio milanese, anche in vista della manifestazione Expo Milano 2015, and presented on the 28th October 2016 to the former Mayor of Milan, Giuliano Pisapia, and to the actual Mayor Giuseppe Sala. The excerpts here proposed regard the problems faced by the Committee in the years which have led up to Expo 2015 and the new scenarios of the presence of the Mafia in the area of Milan. Keywords: Committee of experts; Expo 2015; Milan; ‘ndrangheta; public procurements
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Clinical and ECG investigations in subjects with acute carbon monoxide poisoning
Energy Technology Data Exchange (ETDEWEB)
Capellini, A; Tomasini, M; Limonta, A
1974-01-01
Research carried out on more than 100 workers hospitalized for acute CO poisoning at the Milan Clinica del Lavoro and some 50 subjects undergoing treatment at the Milan polyclinic. The purpose of the research was to investigate the incidence and frequency of myocardial and coronary impairment in cases of acute CO poisoning. The authors concluded from their clinical and ECG findings that myocardial and coronary impairment in subjects suffering from acute CO poisoning was rarely serious or irreversible unless there was preexistent coronary disease. (CIS Abstr. Vol. 2)
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Nash tshelovek v Milane / Ksenia Repson
Repson, Ksenia
2006-01-01
Eesti Kunstiakadeemia tööstusdisaini eriala III kursuse tudeng Pavel Sidorenko sai I koha ja kursusekaaslane Anna-Maria Einla II koha noorte disainerite konkursil Massimo Martini Design Award Milanos. Konkursi korraldusest, Sidorenko ja Einla konkursitöödest
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Facciuto, Marcelo E; Singh, Manoj K; Lubezky, Nir; Selim, Motaz A; Robinson, Dorothy; Kim-Schluger, Leona; Florman, Sander; Ward, Stephen C; Thung, Swan N; Fiel, MariaIsabel; Schiano, Thomas D
2015-01-01
The role of liver transplantation (LT) in the management of cirrhotic patients with tumors exhibiting intrahepatic bile duct differentiation remains controversial. The objective of this study was to characterize the spectrum of these tumors and analyze post-LT outcomes. Retrospective pathology database search of explant histology analysis of liver transplants between April 1993 and November 2013. Thirty-two patients were analyzed, 75% were men with a mean age of 60 years. Seven patients had nodules demonstrating intrahepatic cholangiocarcinoma (I-CCA), nine had I-CCA nodules occurring concomitantly with hepatocellular carcinoma (HCC), and 16 had mixed HCC-CCA nodules. The median number of tumors was 1 and size was 2.5 cm. Overall patient survival post-LT at 1 and 5 years was 71% and 57%, respectively. Patients within Milan criteria, especially with I-CCA features, showed a 5-year tumor recurrence rate (10%) and 5-year survival rate (78%) comparable with other patients having HCC within Milan criteria. This series showed that patients with CCA within Milan criteria may be able to achieve acceptable long-term post-LT survival.
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In the Footsteps of the Lord of Miracles
DEFF Research Database (Denmark)
Pærregaard, Karsten
2008-01-01
One of South America's most famous Catholic icons is the Lord of Miracles, celebrated annually by more than a million people in Lima. Over the past three decades Peru's fast-growing diaspora in Europe, the US, Japan and Argentina has made the Lord of Miracles the object of a global expatriation....... Thus migrants in such cities as Madrid, Barcelona, Milan, Genoa, Rome, Milan, Los Angeles, New York, Washington DC, Tokyo, Kyoto and Buenos Aires organise annual processions to bring the Lord of Miracles to the streets and other public places. This article compares the different strategies migrants...
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Thèses de doctorat soutenues en 2009
Directory of Open Access Journals (Sweden)
2010-04-01
Full Text Available Andrea Vestrucci, Sujet moral et Sittlichkeit : la théorie de la morale de Agnès Heller. Une comparaison avec Eric Weil.Thèse soutenue le 28 janvier 2009 à l’Université de Milan.Composition du juryMaria Cristina Bartolomei, Professeur à l'Université de Milan, co-directrice de thèse Michel Crubellier, Professeur à l'Université de Lille 3Marco Ravera, Professeur à l'Université de TurinPatrice Canivez, Professeur à l'Université de Lille 3, co-directeur de thèse Nathalie Rubel, Sexe et laïcité - ...
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International Nuclear Information System (INIS)
De Man, K.; Defreyne, L.; Delanghe, E.; Smeets, P.; Verhelst, X.; Geerts, A.; Van Vlierberghe, H.; Rogiers, X.; Troisi, R.; Lambert, B.
2015-01-01
Full text of publication follows. Introduction and aim: in our hospital, patients are referred for intra-arterial treatment with Yttrium-90 microspheres if they present with an HCC confined to the liver, but are ineligible for curative treatment options such as liver transplantation, partial hepatectomy or radio-frequent ablation. Additional eligibility criteria for radio-embolisation consist of Child-P ugh score
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Rhu, Jinsoo; Kim, Jong Man; Choi, Gyu Seong; Kwon, Choon Hyuck David; Joh, Jae-Won
2018-02-20
This study was designed to validate the alpha-fetoprotein model for predicting recurrence after liver transplantation in Korean hepatocellular carcinoma patients. Patients who underwent liver transplantation for hepatocellular carcinoma at Samsung Medical Center between 2007 and 2015 were included. Recurrence, overall survival, and disease-specific survival of patients divided by both the Milan criteria and the alpha-fetoprotein model were compared using Kaplan-Meier log-rank test. The predictability of the alpha-fetoprotein model compared to the Milan criteria was tested by means of net reclassification improvement analysis applied to patients with a follow-up of at least 2 years. A total of 400 patients were included in the study. Patients within Milan criteria had 5-year recurrence, and overall survival rates of 20.9% and 76.3% respectively, compared to corresponding rates of 50.3% and 55.7%, respectively, for patients who were beyond Milan criteria. Alpha-fetoprotein model low risk patients had 5-year recurrence and overall survival rates of 21.1% and 76.2%, respectively, compared to corresponding rates of 57.7% and 52.2%, respectively, in high risk patients (P<0.001, all). Although overall net reclassification improvements were statistically nonsignificant for recurrence (NRI=1.7%, Z=0.30, p=0.7624), and overall survival (NRI=9.0%, Z=1.60, p=0.1098), they were significantly better for predicting no recurrence (NRI=6.6%, Z=3.16, p=0.0016) and no death. (NRI=7.7%, Z=3.65, p=0.0003) CONCLUSIONS: The alpha-fetoprotein model seems to be a promising tool for liver transplantation candidacy, but further investigation is needed.
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Directory of Open Access Journals (Sweden)
Riva S
2015-11-01
Full Text Available Silvia Riva,1 Alessandro Antonietti,2 Paola Iannello,2 Gabriella Pravettoni1–3 1Department of Health Sciences, Faculty of Medicine, University of Milan, Milan, Italy; 2Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy; 3Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology, Milan, Italy Objective: The aim of this review is to summarize current research relating to psychological processes involved in judgment and decision-making (JDM and identify which processes can be incorporated and used in the construct of health literacy (HL in order to enrich its conceptualization and to provide more information about people’s preferences.Methods: The literature review was aimed at identifying comprehensive research in the field; therefore appropriate databases were searched for English language articles dated from 1998 to 2015. Results: Several psychological processes have been found to be constituents of JDM and potentially incorporated in the definition of HL: cognition, self-regulation, emotion, reasoning-thinking, and social perception. Conclusion: HL research can benefit from this JDM literature overview, first, by elaborating on the idea that judgment is multidimensional and constituted by several specific processes, and second, by using the results to implement the definition of “judgment skills”. Moreover, this review can favor the development of new instruments that can measure HL. Practical implications: Future researchers in HL should work together with researchers in psychological sciences not only to investigate the processes behind JDM in-depth but also to create effective opportunities to improve HL in all patients, to promote good decisions, and orient patients’ preferences in all health contexts. Keywords: health literacy, judgment, decision-making, psychological processes, skills, cognitive factors
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Na, Gun Hyung; Kim, Dong Goo; Han, Jae Hyun; Kim, Eun Young; Lee, Soo Ho; Hong, Tae Ho; You, Young Kyoung
2014-06-07
To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT). From October 2000 to November 2011, 224 patients who underwent living donor liver transplantation for HCC at our institution were enrolled in this study. We analyzed disease-free survival (DFS) and overall survival (OS) after LT in patients with HCC and designed a new score model using pretransplant neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP). The DFS and OS in patients with an NLR level ≥ 6.0 or CRP level ≥ 1.0 were significantly worse than those of patients with an NLR level < 6.0 or CRP level < 1.0 (P = 0.049, P = 0.003 for NLR and P = 0.010, P < 0.001 for CRP, respectively). Using a new score model using the pretransplant NLR and CRP, we can differentiate HCC patients beyond the Milan criteria with a good prognosis from those with a poor prognosis. Combined with the Milan criteria, new score model using NLR and CRP represent new selection criteria for LDLT candidates with HCC, especially beyond the Milan criteria.
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The stellar spectroscopy laboratory and curriculum counselling for secondary-school students
International Nuclear Information System (INIS)
Cenadelli, D.
2011-01-01
The stellar spectroscopy laboratory is the flagship of a wide-ranging work of curriculum counselling fostered by the Physics Department of the Milan University and the high school 'G. Parini' in Milan. In time, valuable results were gained in setting up a new way of collaboration between the high school and university worlds and in spurring secondary-school students to embark in a scientific, and more specifically physical, career. The present work briefly discusses the contents of the laboratory, its didactical value, its role of curriculum counselling and its effectiveness in directing students to take into consideration the physical sciences as a possible university choice.
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[The Medical Collections of Milan major hospital].
Galimberti, Paolo M
2009-01-01
This essay shows the uncommon occurrence of collections developed in a Hospital. In the past centuries the obstetrical gynaecological (since 18th Century) and anatomical collections (since 1829) were oriented to medical education, while the Pharmacy had a rich equipment. In the first half of 20th century, a Museum open to the public was planned, but the second World War and the absence of interest induce the loss of a large part of the materials. Since 2002 we had censed, collected, and listed the historical instruments, and in 2005 we realized a permanent exhibition. The collections combine about 1500 items. We have especial care to save also modern objects and equipments, after they are disused. At last we hope to realize a real Museum, and we search to assume peculiarities, goals, strength, potentials users, custom.
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Prognostic Value of EEG in Asphyxiated Newborns Treated with Hypothermia
J Gordon Millichap
2008-01-01
Researchers at Children’s Hospitals in Milan, Italy, determined the prognostic value of electroencephalographic patterns in 23 newborns with severe perinatal hypoxic-ischemic encephalopathy, treated with hypothermia.
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Exposição Universal 2015: luzes e sombras sobre a insegurança e a ajuda alimentar na Europa
Directory of Open Access Journals (Sweden)
Cristina Almeida Cunha Filgueiras
2017-01-01
Full Text Available The central purpose of this paper is to question the low visibility of food insecurity and food aid in the current European political context. At first, the reader is invited to a commented and critic visit to Milan 2015 Universal Exhibition. Also, it is demonstrated that food security and food aid remained in second plan in relation to other themes that rich countries prioritized to show the world. Then, the analysis of the main European Food Aid Program is able to demonstrate the social, political and economical relevance of the food insecurity problem in the continent and particularly in France. In second, the article examines the problems of poverty, food insecurity and waste of food in the European context. Third, it is mentioned the main European program of food aid, which existence shows the social, political and economic relevance of the problem in that continent. The case of France, one of the countries whose pavilion was one of the most visited in Milan 2015, which has a portion of its population living in food insecurity and assisted by food aid. Finally, three reasons for the scarce mention of those themes in the event in Milan are presented.
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2013-02-06
... Dura Automotive Systems Milan, TN December 6, 2011. Cable Operations LLC, Control Systems Div... Corporate Division. 82,304 Tyco Electronics, Telecom Shakopee, MN March 3, 2013. Networks Business Unit. 82...
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Green, R J; Herget, M
1991-09-01
This is the third in a series of reports on a small-sample study of systemic/strategic team consultations. It sheds new light on aspects of the therapeutic alliance in Milan-informed therapy. Ratings of the end-of-session interventions and ratings of the therapist's relationship skills (warmth, active structuring) significantly predicted client improvement at 1-month and 3-year followups. These results dispute the Milan team's idea that an intervention's effects are unpredictable. Also, our findings challenge the way some teams have adopted an impersonal, emotionally unresponsive style under the guise of "neutrality." In view of this and other recent studies, we conclude that systemic/strategic therapists should devote more attention to collaborative and affective qualities of the therapeutic alliance.
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American Joint Helicopter Command: Addressing a Lack of Operational Control of Rotary Assets
National Research Council Canada - National Science Library
Marsowicz, Brandon
2007-01-01
... to achieve unity of effort. Based on the tenets of operational command and control by Milan Vego, across all services, the United States helicopter forces fare lacking operational command and control...
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National Research Council Canada - National Science Library
Mauner, Milan
2002-01-01
Although Dr. Milan Hauner's study 'Stalin's Big Fleet program' has focused primarily on the formation of Big Fleets during the Tsarist and Soviet periods of Russia's naval history, there are important lessons...
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A Musical Italy: Michael W. Balfe’s Italian Experiences
Directory of Open Access Journals (Sweden)
Basil Walsh
2016-06-01
Full Text Available The Dublin-born musician, Michael W. Balfe, was a singer, composerand conductor whose brilliant musical career was heavily influenced byformative experiences in Italy. In 1825, Balfe, interested in broadeninghis musical studies first went to Paris where he was introduced to thegreat composers, Luigi Cherubini and Gioachino Rossini, who took apersonal interest in him and his musical talents. On the advice of Rossinihe spent the next few years in Italy studying singing with the famousRossini singer, Filippo Galli, and taking music composition lessonsfrom Ferdinando Paer, in Rome. Later in Milan he studied harmonyand counterpoint with Vincenzo Federici. By 1831, when he was only23 years old, his first three operas had been produced in Palermo, Pavia,and Milan. He returned to London in August 1835, participatingwith the great Lablache, Tamburini, Rubini and Grisi in a concert inVauxhall Gardens. In 1834 he made his debut at La Scala, Milan, singingopposite the renowned mezzo-soprano, Maria Malibran in Rossini’sOtello. He appeared again with Malibran in Venice early in 1835,singing once more in Rossini and Bellini operas. Balfe worked as a singerand composer throughout the Italian peninsula/states during the years,1825-1835 and this article will chart these experiences and demonstratehow the time he spent in Italy and the people he met, influenced hislife and later career as an important and popular European composer.
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Proportional Systems in the History of Architecture: A Conversation with James S. Ackerman
Directory of Open Access Journals (Sweden)
Matthew A Cohen
2014-06-01
Full Text Available In November 2010, James S. Ackerman, today the only living participant of the conference ‘De divina proportione’, which was held in Milan in 1951, sat for a video interview that was later shown at the conference ‘Proportional Systems in the History of Architecture’ in Leiden in 2011 to mark the sixtieth anniversary of the Milan conference. In this interview, conducted by Matthew A. Cohen, Ackerman discusses how the study of proportional systems has changed over the past six decades, and thereby provides a unique link between the two conferences. The interview begins with Ackerman’s experiences in northern Italy at the close of World War II, and a few years later at the Milan conference. It considers prevailing twentieth-century attitudes toward proportion up to the time of the conference, and compares them with prevailing medieval and Renaissance attitudes. Ackerman then shares his thoughts on the works and legacies of Rudolf Wittkower, Le Corbusier and Colin Rowe, before exploring the influences of architectural proportional theory on architectural design, and possible relationships between proportional systems and architectural beauty. After exploring changes in the uses of proportional systems that accompanied the rise of Abstract Expressionism, the arc of the interview concludes with Ackerman’s thoughts about the future of proportional systems in light of the evolving role of the computer in architectural practice today.
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Jungmann: Byl jako postava z Kundery, intelektuál odsouzený k mytí oken
Czech Academy of Sciences Publication Activity Database
Šámal, Petr; Hartman, I.
2012-01-01
Roč. 56, č. 23 (2012), s. 10-10 ISSN 0862-9587 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * literary criticism * Jungmann, Milan Subject RIV: AJ - Letters, Mass-media, Audiovision
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Space Archaeology for military-agricultural colonies (tuntian) on the ancient Silk Road, NW China
Luo, Lei; Wang, Xinyuan; Guo, Huadong; Liu, Chuansheng
2017-04-01
The ancient Silk Road, a pioneering work in the history of human civilization, contributed greatly to the cultural exchange between China and the West. It is the precious cultural heritage should be shared by the whole humanity. Although there were countless archaeological sites along the ancient Silk Road, most of the existing researches just focused on the sites, lacking the overall understanding of the relationships between sites and their supporting environment. Space archaeology provides a new viewpoint for investigating, discovering, reconstructing and documenting the archaeological sites under different scales. The tuntian system was a state-promoted system of military-agricultural colonies, which originated in the Western Han dynasty (206 BC-9 AD). All the imperial dynasties in Chinese history adopted the practice of tuntian to cultivate and guard frontier areas as an important state policy for developing border areas and consolidating frontier defence. This study describes the use of Chinese GF-1 imagery, LS-7 ETM+ data and ASTER GDEMV2 products to uncover an ancient irrigated canal-based tuntian system located in Milan oasis adjacent to the ancient Kingdom of Loulan at the southern margin of the Tarim Basin. The GF-1 and LS-7 data were first processed following atmospheric and geometric correction and enhanced by Gram Schmidt pansharpening. The linear archaeological traces of tuntian irrigation canals were extracted from the morphologically enhanced GF-1 PAN imagery using our proposed automatic method which adopts mathematical morphological processing and Canny edge operator. Compared with the manual extractions, the overall detection accuracy was better than 90%. In addition, the functions of the trunk, primary, secondary and tertiary canals were each analyzed and the spatial extent of Milan's tuntian landscape were analyzed with the help of the NDVI derived from the GF-1 multispectral imagery. The effective irrigated tuntian area was estimated to be 2
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Modern Milano. A survey about transformation of architectural and urban heritage
Directory of Open Access Journals (Sweden)
Giovanna D’Amia
2009-12-01
Full Text Available The XX Century Milan estate of buildings records the renovation of the culture and the predominance of the Rationalism between the World Wars and the Second postwar. Nevertheless, it is still unknown and poorly documented and it has often suffered radical transformations. Giovanna D’Amia and Luca Tamini formulated an hypothesis of an observatory of the Modern Milan as an interdisciplinary research to deeply know and valorise this estate of buildings, to survey their conditions and to propose guidelines for future interventions. An archive of data and graphic documents of 45 selected buildings has been created by Giovanna D’Amia Course of Contemporary History of Architecture (year 2008/2009 in order to verify the fairness of this approach. Nowadays it is possible to drew up a first balance of the research.
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Knowledge Communication in Green Corporate Marketing
DEFF Research Database (Denmark)
Maier, Carmen Daniela
2011-01-01
This article explores how several types of knowledge are communicated through the simultaneous deployment of two semiotic modes in the Milan video existing on GE Corporation's website. The video is part of the Ecomagination marketing campaign promoting environmentally friendly products and positi......This article explores how several types of knowledge are communicated through the simultaneous deployment of two semiotic modes in the Milan video existing on GE Corporation's website. The video is part of the Ecomagination marketing campaign promoting environmentally friendly products...... and positioning GE as an eco-friendly corporation. The specific aim of my analytical endeavor is to identify how the meaning-making potentials of language and images are integrated, and how this multimodal integration influences the persuasive communication of knowledge types. Key words: multimodal discourse...... analysis; knowledge communication; environmental discourse; green corporate marketing...
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Předmluva k pátému číslu: Pocta Milanu Mrázovi
Czech Academy of Sciences Publication Activity Database
Boháček, Kryštof
2011-01-01
Roč. 3, č. 5 (2011), s. 1-8 ISSN 1803-7860 Institutional research plan: CEZ:AV0Z90090514 Keywords : Aither * Ancient Philosophy * medieval Philosophy * tribute to Milan Mraz Subject RIV: AA - Philosophy ; Religion
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Analysis of only 0-1 min clip or 1-4 min Clip for focal liver lesions ...
African Journals Online (AJOL)
1Department of Medical Ultrasound, 2Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong ... The injection of ultrasound ... Imaging, Milan, Italy), a second generation ... at 7, mechanical index at 0.03, acoustic power at.
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Didattica universitaria a distanza con la telematica e la televisione
Directory of Open Access Journals (Sweden)
Attilio Costa
1993-01-01
Full Text Available Reflections on the experience of the Milan Polytechnic in the field of educational technology. Presents some significant steps in this direction, along with reading grid to outline the possible types of distance learning.
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75 FR 77945 - Qualification of Drivers; Exemption Applications; Vision
2010-12-14
... Christopher J. McCulla Dickie R. Clough Darris Hardwidge Darrell Rogers Scott A. Cole Shawn M. Hebert Karl H. Strangfeld Richard W. Futrell Milan Jokic Jacob E. Wadewitz Carlos R. Galarza Douglas Jones Stephen H. Ward...
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2017-2018 Travel Expense Reports for Dominique Corti, Governor
International Development Research Centre (IDRC) Digital Library (Canada)
SD
07-11. Destination(s):. Kenya, Uganda and Tanzania. Airfare: $5,319.87. Other. Transportation: $82.43. Accommodation: $2,107.26. Meals and. Incidentals: $317.46. Other: $260.82. Total: $8,087.84. Comments: Residence in Milan, Italy.
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1998-12-01
Bromoform Bromomethane iso -Butanol n-Butanol 2-Butanone n-Butylbenzene sec-Butylbenzene tert-Butylbenzene Carbon disulfide Carbon tetrachloride...1994 TABLE 10 DIRECT INJECTION .ANALYSIS OF NEW OIL AT 5 PPM Compound Acetone Benzene n-Butanol*,** iso -Butanol*,** Carbon tetrachlorid Carbon...Sediment 48.0 48.0 2977 16.2 Autocl.sediment 53.7 2.7 15.7 11.0 83.1 12755 16.2 Gravel 53.1 6.8 7.8 8.7 76.4 8583 16.2 Autocl.gravel 11.0 7.7
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Directory of Open Access Journals (Sweden)
LinWei Wu
Full Text Available OBJECTIVE: To summarize the experience with salvage liver transplantation (SLT for patients with recurrent hepatocellular carcinoma (HCC after primary hepatic resection in a single center. METHODS: A total of 376 adult patients with HCC underwent orthotopic liver transplantation (OLT at Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, between 2004 and 2008. Among these patients, 36 underwent SLT after primary liver curative resection due to intrahepatic recurrence. During the same period, one hundred and forty-seven patients with HCC within Milan criteria underwent primary OLT (PLTW group, the intra-operative and post-operative parameters were compared between these two groups. Furthermore, we compared tumor recurrence and patient survival of patients with SLT to 156 patients with HCC beyond Milan criteria (PLTB group. Cox Hazard regression was made to identify the risk factors for tumor recurrence. RESULTS: The median interval between initial liver resection and SLT was 35 months (1-63 months. The intraoperative blood loss (P0.05. When compared to those patients with HCC beyond Milan criteria undergoing primary OLT, patients undergoing SLT achieved a better survival and a lower tumor recurrence. Cox Proportional Hazards model showed that vascular invasion, including macrovascular and microvascular invasion, as well as AFP level >400 IU/L were risk factors for tumor recurrence after LT. CONCLUSIONS: In comparison with primary OLT, although SLT is associated with increased operation difficulties, it provides a good option for patients with HCC recurrence after curative resection.
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Energy Technology Data Exchange (ETDEWEB)
Choi, Tae Won; Kim, Hyo Cheol; Lee, Jeong Hoon; Yu, Su Jong; Kang, Beom Sik; Hur, Sae Beom; Lee, Myung Su; Jae, Hwan Jun; Chung, Jin Wook [Seoul National University College of Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)
2015-12-15
To evaluate the safety and clinical outcomes of chemoembolization in Child-Pugh class C patients with hepatocellular carcinomas (HCC). The study comprised 55 patients with HCC who were classified as Child-Pugh class C and who underwent initial chemoembolization between January 2003 and December 2012. Selective chemoembolization was performed in all technically feasible cases to minimize procedure-related complications. All adverse events within 30 days were recorded using the Common Terminology Criteria for Adverse Events (CTCAE). The tumor response to chemoembolization was evaluated using the modified Response Evaluation Criteria In Solid Tumors. Thirty (54.5%) patients were within the Milan criteria, and 25 (45.5%) were beyond. The mortality of study subjects at 30 days was 5.5%. Major complications were observed in five (9.1%) patients who were all beyond the Milan criteria: two hepatic failures, one hepatic encephalopathy, and two CTCAE grade 3 increases in aspartate aminotransferase/alanine aminotransferase abnormality. The mean length of hospitalization was 6.3 ± 8.3 days (standard deviation), and 18 (32.7%) patients were discharged on the next day after chemoembolization. The tumor responses of the patients who met the Milan criteria were significantly higher (p = 0.014) than those of the patients who did not. The overall median survival was 7.1 months (95% confidence interval: 4.4-9.8 months). Even in patients with Child-Pugh class C, chemoembolization can be performed safely with a selective technique in selected cases with a small tumor burden.
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Practical guidelines for familial combined hyperlipidemia diagnosis: an up-date
Directory of Open Access Journals (Sweden)
Antonio Gaddi
2008-01-01
Full Text Available Antonio Gaddi1, AFG Cicero1, FO Odoo2, A Poli A3, R Paoletti4On behalf of the Atherosclerosis and Metabolic Diseases Study Group 1Center for Metabolic diseases and Atherosclerosis, University of Bologna, Italy; 2Creighton University Medical Center, Omaha, NE, USA; 3Nutrition Foundation of Italy, Milan, Italy; 4Department of Pharmacological Sciences, University of Milan, Milan, ItalyAbstract: Familial combined hyperlidemia (FCH is a common metabolic disorder characterized by: (a increase in cholesterolemia and/or triglyceridemia in at least two members of the same family, (b intra-individual and intrafamilial variability of the lipid phenotype, and (c increased risk of premature coronary heart disease (CHD. FCH is very frequent and is one of the most common genetic hyperlipidemias in the general population (prevalence estimated: 0.5%–2.0%, being the most frequent in patients affected by CHD (10% and among acute myocardial infarction survivors aged less than 60 (11.3%. This percentage increases to 40% when all the myocardial infarction survivors are considered without age limits. However, because of the peculiar variability of laboratory parameters, and because of the frequent overlapping with the features of metabolic syndrome, this serious disease is often not recognized and treated. The aim of this review is to define the main characteristics of the disease in order to simplify its detection and early treatment by all physicians by mean of practical guidelines.Keywords: familial combined hyperlipidemia, guidelines, diagnosis, management
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Normet, Mart, 1979-
2006-01-01
Uutest DVD-dest U2 "ZooTV: Live From Sydney", Cool D "Legaalselt eetris", Pink Floyd "Pulse", Depeche Mode "Touring The Angel: Live In Milan", Rammstein "Völkerball", Metsatöll "Lahinguväljal näeme, raisk"
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Harvesting Collective Trend Observations from Large Scale Study Trips
DEFF Research Database (Denmark)
Eriksen, Kaare; Ovesen, Nis
2014-01-01
To enhance industrial design students’ decoding and understanding of the technological possibilities and the diversity of needs and preferences in different cultures it is not unusual to arrange study trips where such students acquire a broader view to strengthen their professional skills and app...... numbers of students to the annual Milan Design Week and the Milan fair ‘I Saloni’ in Italy. The present paper describes and evaluates the method, the theory behind it, the practical execution of the trend registration, the results from the activities and future perspectives....... and approach, hence linking the design education and the design culture of the surrounding world. To improve the professional learning it is useful, though, to facilitate and organize the trips in a way that involves systematic data collection and reporting. This paper presents a method for facilitating study...
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Histochemistry for the research in veterinary science: the legacy of Giuseppe Aureli
Directory of Open Access Journals (Sweden)
A Lauria
2009-06-01
Full Text Available Twenty years ago, on April 24th 1984, Giuseppe Aureli, Founding Member and President of the Italian Society of Histochemistry from 1971 to 1973, Director of the Institute of Anatomy of Domestic Animals, Histology and Embryology and Dean of the School of Veterinary Medicine of the University of Milan, died suddenly and before his time. Following in the footsteps of Carlo Bignardi, he started from the time he was a student, to deal with the research approaches of Maffo Vialli, founder of histochemistry in Italy Head in Milan of a skilled group of scientists, he developed a sound and reliable research school mainly based on the use of ever more advanced histochemical and cytochemical techniques to study, in the extensive area of veterinary science, different problems aimed at developing either basic knowledge or animal production.
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LCA Comparison of waste incineration in Denmark and Italy
DEFF Research Database (Denmark)
Turconi, Roberto; Butera, Stefania; Boldrin, Alessio
2011-01-01
Every year around 50 millions Mg solid waste are incinerated in Europe. Large differences exist in different regions, mainly regarding energy recovery, flue gas treatment and management of solid residues. This paper aims to identify and quantify those differences, providing a Life Cycle Assessment...... of two incinerator systems that are representative of conditions in Northern and Southern Europe. The two case studies are Aarhus (Denmark) and Milan (Italy). The results show that waste incineration appears more environmentally friendly in the Danish case than in the Italian one, due to the higher...... energy recovery and to local conditions, e.g. substitution of electricity and heat in the area. Focusing on the incineration process, Milan incinerator performs better than Aarhus, since its upstream impacts (related to the production of chemicals used in flue gas cleaning) are more than compensated...
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Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes. Dhananjay Dey Arnab Basu Roy Anandan Ranjani Loganathan Gayathri Saravanan Chandraleka Dharumadurai Dhanasekaran Mohammad Abdulkader Akbarsha Chung-Yu Shen Hui-Lien Tsai Milan Maji Niranjan Kole Bhaskar ...
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Simplified Classification of Focal Cortical Dysplasia
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2002-09-01
Full Text Available Sections of cortex from 52 of 224 (23% patients with cortical dysplasia, operated on for drug-resistant partial epilepsy, were retrospectively re-examined histologically at Niguarda Hospital, and Istituto Nazionale Neurologico ‘C. Besta’, Milan, Italy.
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Ministeeriumi kantslerid tegid kohtumisel 25 000-eurose mürtsu / Kelli Seiton
Seiton, Kelli
2013-01-01
Kaitseministeeriumi korraldatud erinevate ministeeriumite kantslerite kokkusaamisest, mille käigus viidi kaitseväe keskpolügoonil läbi näidislaskmine ning lasti õhku tankitõrjerakett Milan 2, mille maksumus on väidetavalt 25 000 eurot
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CSF Markers in Guillain-Barre Syndrome
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2007-01-01
Full Text Available A positive 14-3-3 protein assay of CSF was observed in 29 of 38 patients with GBS and in 4 with motor neuron disease and other neuropathies studied at Universities of Milan and Verona, Italy.
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1985-12-31
nuts, chestnuts, f ilberts, hazelnuts, pecans , walnuts (all nuts, in %hells). In other countries, the appropriate government regulatory agencies...75012 Paris, France, 10 Rue Villiot .. ...... . . . . . . 347.87-45 NEAR EAST 20124 Milan, Italy , Via Rosellini 12 ... ...... ...... 688.4563 Hemel
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Czech Academy of Sciences Publication Activity Database
Hájková, Dagmara
2017-01-01
Roč. 30, 30. 9. (2017), s. 30 ISSN 0862-5921 Grant - others:AV ČR(CZ) StrategieAV21/12 Program:StrategieAV Institutional support: RVO:67985921 Keywords : Milan Rastislav Štefánik Subject RIV: AB - History
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2013-01-04
... Industries Irvine, CA 12/05/12 12/03/12 (previous name was under (Company). 82215 Sharp Electronics Camas, WA... Springs, AR........ 12/07/12 12/06/12 Stop). 82225 Dura Automotive Systems LLC Milan, TN 12/07/12 12/06/12...
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Marcińczak, S.; Musterd, S.; van Ham, M.; Tammaru, T.; Tammaru, T.; Marcińczak, S.; van Ham, M.; Musterd, S.
2016-01-01
The Socio-Economic Segregation in European Capital Cities: East Meets West project investigates changing levels of socio-economic segregation in 13 major European cities: Amsterdam, Budapest, Vienna, Stockholm, Oslo, London, Vilnius, Tallinn, Prague, Madrid, Milan, Athens and Riga. The two main
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LIBO - boosting medical cyclotron facilities for cancer therapy Exhibition LEPFest 2000
2000-01-01
Length : Energy boost : From 62 to 200 MeVAccelerating gradient : 10 MeV/metreAccelerating frequency : 3 GHz Collaboration : CERN, INFN and University of Milan, INFN and University of Naples and TERA foundation Prototype test in 2001 : SC cyclotron Catania
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Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes · Dhananjay Dey Arnab Basu Roy Anandan Ranjani Loganathan Gayathri Saravanan Chandraleka Dharumadurai Dhanasekaran Mohammad Abdulkader Akbarsha Chung-Yu Shen Hui-Lien Tsai Milan Maji Niranjan Kole Bhaskar ...
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Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Unprecedented hetero-geometric discrete copper(II) complexes: Crystal structure and bio-mimicking of Catecholase activity. ABHRANIL DE DHANANJAY DEY HARE RAM YADAV MILAN MAJI VINAYAK RANE R M KADAM ANGSHUMAN ROY CHOUDHURY BHASKAR BISWAS. Regular Article Volume 128 Issue 11 ...
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Czech Academy of Sciences Publication Activity Database
Monhart, Z.; Faltus, Václav; Grünfeldová, H.; Ryšavá, D.; Velimský, T.; Ballek, J.; Hubač, J.; Janský, P.
2007-01-01
Roč. 25, Suppl. 2 (2007), S 360-S361 ISSN 0952-1178. [European Meeting on Hypertension /17./. 15.06.2007-19.06.2007, Milan] Institutional research plan: CEZ:AV0Z10300504 Keywords : arterial hypertension * myocardial infarction * short-term mortality
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Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease
Directory of Open Access Journals (Sweden)
Santus P
2017-11-01
Full Text Available Pierachille Santus,1 Dejan Radovanovic,1 Andrea Cristiano,1 Vincenzo Valenti,2 Maurizio Rizzi1 1Department of Biomedical and Clinical Sciences (DIBIC, University of Milan, Division of Respiratory Diseases, “L. Sacco” Hospital, ASST Fatebenefratelli Sacco, Milan, Italy; 2Department of Health Bioscience, University of Milan – Respiratory Unit, Policlinico di San Donato, IRCCS – San Donato Milanese, Milan, Italy Abstract: In the upcoming years, the proportion of elderly patients with chronic obstructive pulmonary disease (COPD will increase, according to the progressively aging population and the increased efficacy of the pharmacological treatments, especially considering the management of chronic comorbidities. The issue to prescribe an appropriate inhalation therapy to COPD patients with significant handling or coordination difficulties represents a common clinical experience; in the latter case, the choice of an inadequate inhalation device may jeopardize the adherence to the treatment and eventually lead to its ineffectiveness. Treatment options that do not require particular timing for coordination between activation and/or inhalation or require high flow thresholds to be activated should represent the best treatment option for these patients. Nebulized bronchodilators, usually used only in acute conditions such as COPD exacerbations, could fulfill this gap, enabling an adequate drug administration during tidal breathing and without the need for patients’ cooperation. However, so far, only short-acting muscarinic antagonists have been available for nebulization. Recently, a nebulized formulation of the inhaled long-acting muscarinic antagonist glycopyrrolate, delivered by means of a novel proprietary vibrating mesh nebulizer closed system (SUN-101/eFlow®, has progressed to Phase III trials and is currently in late-stage development as an option for maintenance treatment in COPD. The present critical review describes the current
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Aortic Valve Replacement With the Stentless Freedom SOLO Bioprosthesis: A Systematic Review
Wollersheim, Laurens W.; Li, Wilson W.; Bouma, Berto J.; Repossini, Alberto; van der Meulen, Jan; de Mol, Bas A.
2015-01-01
This systematic review examined the clinical and hemodynamic performance of the stentless Freedom SOLO (Sorin Group, Milan, Italy) aortic bioprosthesis. The occurrence of postoperative thrombocytopenia was also analyzed. The Freedom SOLO is safe to use in everyday practice, with short cross-clamp
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Czech Academy of Sciences Publication Activity Database
Brož, J.; Holubová, A.; Mužík, J.; Oulická, M.; Mužný, M.; Poláček, M.; Fiala, D.; Arsand, E.; Brabec, Marek; Kvapil, M.
2016-01-01
Roč. 18, Suppl. 1 (2016), A70-A70 ISSN 1520-9156. [ATTD 2016. International Conference on Advanced Technologies & Treatments for Diabetes /9./. 03.02.2016-06.02.2016, Milan] Institutional support: RVO:67985807 Subject RIV: BB - Applied Statistics, Operational Research
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Electronic Form of the 1999 WHO/ISH Hypertension Guidelines
Czech Academy of Sciences Publication Activity Database
Peleška, Jan; Anger, Z.; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana
21 Suppl. 4, - (2003), s. 181 ISSN 0263-6352. [European Meeting on Hypertension /13./. 13.06.2003-17.06.2003, Milan] R&D Projects: GA MŠk LN00B107 Keywords : hypertension * WHO/ISH guidelines * electronic guidelines Subject RIV: BA - General Mathematics
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Field Portable GC-MS Unit for Semi-Volatile Compound Analysis in Groundwater
2011-06-01
the size and power consumption compared to standard GC systems. These modifications to the instrument design all serve to decrease the size and...Environment Mass Spectrometry (HEMS) Conference, September 2007, Cocoa Beach, FL. USEPA. 1998. USEPA Superfund Record of Decision, Milan Army
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Indian Academy of Sciences (India)
ABHRANIL DEa, DHANANJAY DEYa, HARE RAM YADAVb, MILAN MAJIc, VINAYAK RANEd, R M KADAMd, ANGSHUMAN ROY CHOUDHURYb and BHASKAR BISWAS*, a. aDepartment of Chemistry, Raghunathpur College, Purulia, West Bengal, 723 133 India. bDepartment of Chemical Sciences, Indian Institute of ...
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Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities
Le Tertre, A; Medina, S; Samoli, E; Forsberg, B; Michelozzi, P; Boumghar, A; Vonk, JM; Bellini, A; Atkinson, R; Ayres, JG; Sunyer, J; Schwartz, J; Katsouyanni, K
2002-01-01
Study objective: As part of the APHEA project this study examined the association between airborne particles and hospital admissions for cardiac causes (ICD9 390-429) in eight European cities (Barcelona, Birmingham, London, Milan, the Netherlands, Paris, Rome, and Stockholm). All admissions were
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Club d'Orientation
2012-01-01
Relais inter-club/Challenge Carlo Milan Samedi dernier, lors de l’épreuve de course d’orientation organisée par le club du O’Jura, le moteur de la discipline était l’esprit d’équipe, puisqu’il était question d’un relais inter-club avec le Challenge Carlo Milan. Les clubs avaient aligné leurs coureurs soit sur le relais technique (trois participants) soit sur le relais facile (deux participants). Côté O’Jura, il fallait noter la participation de François Gonon, champion du monde 2011, côté club du CERN, Marie et Gaëtan Vuitton, jeunes espoirs du club, devaient préparer la piste pour lancer le dernier relayeur. Côté Lausanne-Jorat, il fallait compter sur le très jeune Viktor Kuznetsov. Les 31 équipes engagées n’ont pas m&ea...
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The Castilian Translations of Quintus Curtius in their Manuscript and Cultural Context
DEFF Research Database (Denmark)
Rodríguez Porto, Rosa María; Pascual-Argente, Clara
2018-01-01
In 1438, Milanese humanist Pier Candido Decembrio finished the vernacular translation of Quintus Curtius’s Historiae Alexandre Magni, made at the request of his patron, Duke Filippo Maria Visconti of Milan, and accompanied it with a work of his own, the Comparatione di Cesare et d’Alexandro. Dece......In 1438, Milanese humanist Pier Candido Decembrio finished the vernacular translation of Quintus Curtius’s Historiae Alexandre Magni, made at the request of his patron, Duke Filippo Maria Visconti of Milan, and accompanied it with a work of his own, the Comparatione di Cesare et d...... Castilian version by Aragonese nobleman Alfonso de Liñán; and a Catalan translation printed in 1481. These versions have yet to receive the sustained critical attention they deserve. In this article, we will argue that the Iberian translations of Decembrio’s Alexandrine works are critical to our...
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Study of sulphation of Candoglia marble by means of micro X-ray diffraction experiments
Pedrazzani, R.; Alessandri, I.; Bontempi, E.; Cappitelli, F.; Cianci, M.; Pantos, E.; Toniolo, L.; Depero, L. E.
2006-06-01
This research is aimed at assessing the particular kind of damage caused by the interaction between atmospheric pollution and the marble surface of a magnificent late gothic church, Milan Cathedral, restored in the early 1970s. On the basis of visual inspections and diagnostic investigations the facade appears to be seriously damaged by surface erosion and thick black crusts; biological crusts, micro-fractures and detachments are widely present. This paper reports on SR-μXRD data collected at the Synchrotron Radiation Source (SRS), Daresbury Laboratory, and at the European Synchrotron Radiation Source (ESRF) from selected samples, covered with black crusts, originating from the Milan Cathedral facade. Mineralogical maps of the deterioration layers have been recorded by two spatial resolutions (5-100 μm), from the bulk of the stone material to the outer layer of the black surface. These maps help in elucidating the mechanism of formation of the black crusts.
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Defibrotide in the treatment of hepatic veno-occlusive disease
Directory of Open Access Journals (Sweden)
Fulgenzi A
2016-10-01
Full Text Available Alessandro Fulgenzi, Maria Elena Ferrero Department of Biomedical Sciences for Health, University of Milan, Milan, Italy Abstract: Hepatic veno-occlusive disease (VOD, also known as sinusoidal obstruction syndrome (SOS, represents the most frequent complication in patients in early phase following hematopoietic stem-cell transplantation (HSCT. In its severe form, VOD/SOS can be associated with multiorgan failure and with a mortality rate >80% by day +100. Defibrotide (DF (a mixture of 90% single-stranded phosphodiester oligonucleotides and 10% double-stranded phosphodiester oligonucleotides derived from controlled depolarization of porcine intestinal mucosal DNA has been proposed for the treatment of SOS due to its ability to restore thrombo-fibrinolytic balance and protect endothelial cells. The present review highlights why the mechanisms of action of DF allow its successful use in the prevention and treatment of SOS following HSCT. Keywords: hepatic veno-occlusive disease, hematopoietic stem-cell transplantation, defibrotide
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1998-12-01
recommended to avoid possi- ble contamination.) Use the first 50- 100 mL to rinse the filter flask. Dis- card this portion and collect the...water. Dilute to 1 liter. 6.3.2.13 Starch indicator solution: To 5 grams of starch ( potato , arrowroot, or soluble), add a little cold deionized...treatments. S„^«Ty fta ?e dunng **P°suns. However, the Detailed records of feeding rates and the appearance of addition of the food may alter the
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Lee, Sanghoon; Hyuck David Kwon, Choon; Man Kim, Jong; Joh, Jae-Won; Woon Paik, Seung; Kim, Bong-Wan; Wang, Hee-Jung; Lee, Kwang-Woong; Suh, Kyung-Suk; Lee, Suk-Koo
2014-09-01
Salvage liver transplantation (LT) is considered a feasible option for the treatment of recurrent hepatocellular carcinoma (HCC). We performed this multicenter study to assess the risk factors associated with the recurrence of HCC and patient survival after salvage LT. Between January 2000 and December 2011, 101 patients who had previously undergone liver resection (LR) for HCC underwent LT at 3 transplant centers in Korea. Sixty-nine patients' data were retrospectively reviewed for the analysis. The recurrence of HCC was diagnosed at a median of 10.6 months after the initial LR, and patients underwent salvage LT. Recurrences were within the Milan criteria in 48 cases and were outside the Milan criteria in 21 cases. After salvage LT, 31 patients had HCC recurrence during a median follow-up period of 24.5 months. There were 24 deaths, and 20 were due to HCC recurrence. The 5-year overall survival rate was approximately 54.6%, and the 5-year recurrence-free survival rate was 49.3%. HCC recurrence within the 8 months after LR [hazard ratio (HR) = 3.124, P = 0.009], an alpha-fetoprotein level higher than 200 ng/mL (HR = 2.609, P = 0.02), and HCC outside the Milan criteria at salvage LT (HR = 2.219, P = 0.03) were independent risk factors for poor recurrence-free survival after salvage LT. In conclusion, the timing and extent of HCC recurrence after primary LR both play significant roles in the outcome of salvage LT. © 2014 American Association for the Study of Liver Diseases.
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Cugerone, Katia; De Michele, Carlo; Ghezzi, Antonio; Gianelle, Vorne; Gilardoni, Stefania
2018-04-01
Particle number size distributions (PNSDs) have been collected periodically in the urban area of Milan, Italy, during 2011 and 2012 in winter and summer months. Moreover, comparable PNSD measurements were carried out in the rural mountain site of Oga-San Colombano (2250 m a.s.l.), Italy, during February 2005 and August 2011. The aerosol data have been measured through the use of optical particle counters in the size range 0.3-25 µm, with a time resolution of 1 min. The comparison of the PNSDs collected in the two sites has been done in terms of total number concentration, showing higher numbers in Milan (often exceeding 103 cm-3 in winter season) compared to Oga-San Colombano (not greater than 2×102 cm-3), as expected. The skewness-kurtosis plane has been used in order to provide a synoptic view, and select the best distribution family describing the empirical PNSD pattern. The four-parameter Johnson system-bounded distribution (called Johnson SB or JSB) has been tested for this aim, due to its great flexibility and ability to assume different shapes. The PNSD pattern has been found to be generally invariant under site and season changes. Nevertheless, several PNSDs belonging to the Milan winter season (generally more than 30 %) clearly deviate from the standard empirical pattern. The seasonal increase in the concentration of primary aerosols due to combustion processes in winter and the influence of weather variables throughout the year, such as precipitation and wind speed, could be considered plausible explanations of PNSD dynamics.
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The roots of modern oncology: from discovery of new antitumor anthracyclines to their clinical use.
Cassinelli, Giuseppe
2016-06-02
In May 1960, the Farmitalia CEO Dr. Bertini and the director of the Istituto Nazionale dei Tumori of Milan Prof. Bucalossi (talent scout and city's Mayor) signed a research agreement for the discovery and development up to clinical trials of new natural antitumor agents. This agreement can be considered as a pioneering and fruitful example of a translational discovery program with relevant transatlantic connections. Owing to an eclectic Streptomyces, found near Castel del Monte (Apulia), and to the skilled and motivated participants of both institutions, a new natural antitumor drug, daunomycin, was ready for clinical trials within 3 years. Patent interference by the Farmitalia French partner was overcome by the good quality of the Italian drug and by the cooperation between Prof. Di Marco, director of the Istituto Ricerche Farmitalia Research Laboratories for Microbiology and Chemotherapy, and Prof. Karnofsky, head of the Sloan-Kettering Cancer Institute of New York, leading to the first transatlantic clinical trials. The search for daunomycin's sister anthracyclines led to the discovery and development of adriamycin, one of the best drugs born in Milan. This was the second act prologue of the history of Italian antitumor discovery and clinical oncology, which started in July 1969 when Prof. Di Marco sent Prof. Bonadonna the first vials of adriamycin (doxorubicin) to be tested in clinical trials. This article reviews the Milan scene in the 1960s, a city admired and noted for the outstanding scientific achievements of its private and public institutions in drugs and industrial product discovery.
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Directory of Open Access Journals (Sweden)
Maurizio Gorla
2016-10-01
Full Text Available CAP Group is a public company, supplying the municipalities within the provinces of Milan and Monza/Brianza (Northern Italy with the integrated water service: 197 municipalities and more than 2 million users served, 887 wells, 154 wall-mounted tanks and hubs, a water supply network of over 7500 km, from which approximately 250 million cubic metres of water per year are withdrawn. The drinking water supply comes exclusively from groundwater resources, circulating in several overlapping aquifer systems. Basin-scale water resource management, as required by the European Water Framework Directive (2000/60/EC, is an extremely complex task. In view of this backdrop, CAP is currently developing a project called Infrastructural Aqueduct Plan that relies on a Decision Support System approach. The paper describes the preliminary steps concerning the design of a prototype Decision Support System aiming at the management of groundwater resources on a basin scale (Ticino and Adda rivers area. CAP Group Decision Support System is intended to be a package allowing for water resource assessment, identification of boundary conditions, climatic driving forces and demographic pressures, simulation and investigation of future forecasts and comparison of alternative policy measures. The project has been designed in steps including Geodatabase building, geographic information system (GIS analysis (including multilayer analysis and numerical modelling. The data collected in the geodatabase were analyzed to design GIS quantitative and qualitative thematic maps in order to perform the multilayer analysis of current and future state and impacts, for providing the decision maker with a comprehensive picture of the water system. The multilayer analysis relies on specific indicators based on some quantitative and qualitative data: hydrogeological, chemical, isotopic, soil use and hazards, climatic and demographic. Each parameter belonging to these macro areas were
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Liver transplantation in patients with hepatocellular carcinoma
Polak, Wojciech G.; Soyama, Akihiko; Slooff, Maarten J. H.
2008-01-01
Liver transplantation has a definitive place in the treatment of patients with hepatocellular carcinoma (HCC) in a cirrhotic liver. Patients with a tumor load within the Milan criteria have excellent survival comparable to survival in patients with benign indications. When tumor load exceeds the
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Cognitive Disorders in Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2007-04-01
Full Text Available Intelligence and language functions were examined in 24 children (mean age 9 yrs; range 7-12 yrs with BECTS and compared with a group of 16 controls matched for age and schooling, in a study at the Instituto Nazionale Neurologico, Milan, Italy.
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Löhe, Florian; Angele, Martin K.; Rentsch, Markus; Graeb, Christian; Gerbes, Alexander; Löhrs, Udo; Beuers, Ulrich; Jauch, Karl-Walter
2008-01-01
BACKGROUND AND AIMS: Liver transplantation (OLT) for hepatocellular carcinoma (HCC) improves patient survival when tumor size and number are limited according to the Milan criteria. However, the impact of tumor size vs. the number of lesions for tumor recurrence after OLT is unclear. Microvascular
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Kokk discusses unified foreign service with Czechs / Ella Karapetyan
Karapetyan, Ella
2010-01-01
Välisministeeriumi kantsler Marten Kokk kohtus Tšehhi Euroopa asjade asevälisministri Vladimir Galuska ja haldusküsimuste aseministri Milan Sedlacekiga. Kohtumistel räägiti Euroopa Liidu välisteenistuse loomisest, Euroopa Liidu laienemisest ja idapartnerlusest ning Eesti ja Tšehhi vahelistest suhetest
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Hydroelectric power plants may influence profit of company
International Nuclear Information System (INIS)
Regula, E.
2006-01-01
In this interview with divisional manager of the Division of control of operation of hydroelectric power plants of the Slovenske elektrarne, a.s. Mr. Milan Chudy is published. The effectiveness and its optimisation in hydroelectric power plants of the Slovenske elektrarne, a.s. are discussed
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The Element of Space in Development Planning
L.B.M. Mennes (Loet); J.G. Waardenburg (George); J. Tinbergen (Jan)
1969-01-01
textabstractIn Italian: Lo Spazio nei Piani Economici, Franco Angeli Editore, Milan, 1972, 391 p. In Spanish: El Factor Espacio en la Planificación del Desarollo, Series ‘Fondo de Cultura Económica’, Fondo de Cultura Económica, Mexico, 1980, 405 p.
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2013-12-09
..., Norman, OK; Helicon Chemical Company LLC, Orlando, FL; Lewis Machine & Tool Company, Milan, IL; Lund..., Blackhawk Management, Houston, TX; Blue Juice, Inc., San Rafael, CA; Engineering and Management Executives... FR 52787). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2013-29272...
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Bilge dump detection from SAR imagery using local binary patterns
CSIR Research Space (South Africa)
Mdakane, LW
2015-07-01
Full Text Available 2015: Remote Sensing: Understanding the Earth for a Safer World, Milan, Italy, 26-31 July 2015 Bilge dump detection from SAR imagery using local binary patterns yz L.W. Mdakane,yz W. Kleynhans,yz C.P. Schwegmann yDepartment of Electrical...
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DEFF Research Database (Denmark)
Bazzichelli, Tatiana
of Italian hacker communities. Book written by Tatiana Bazzichelli, with the preface of Derrick De Kerckhove and the epilogue of the videoartist Simonetta Fadda. Costa & Nolan Ed., Milan, Italy, 2006. English edition (2009): Digital Aesthetics Research Center, Aarhus University, Denmark. networkingart.eu/the-book/...
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Anderson, HR; Spix, C; Medina, S; Schouten, JP; Castellsague, J; Rossi, G; Zmirou, D; Touloumi, G; Wojtyniak, B; Ponka, A; Bacharova, L; Schwartz, J; Katsouyanni, K
We investigated the short-term effects of air pollution on hospital admissions for chronic obstructive pulmonary disease (COPD) in Europe. As part of a European project (Air Pollution and Health, a European Approach (APHEA)), we analysed data from the cities of Amsterdam, Barcelona, London, Milan,
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Debates and diatribes in Milanese religious orders at the time of Boscovich.
Buzzi, F.
Many religious orders were involved in education at the time of Boscovich, but I thought that it would be useful to focus on the Barnabites and the Jesuits, which were extremely active in Milan in that period. Debates and diatribes among these two religious orders are discussed.
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77 FR 49436 - 36(b)(1) Arms Sales Notification
2012-08-16
... military modernization program. The Javelin system will replace the Belgium Army's existing MILAN missile system. The proposed sale of the missiles and support will not alter the basic military balance in the... and other related logistics support. (iv) Military Department: Army (WDM) (v) Prior Related Cases, if...
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Teachers' Ideas about Health: Implications for Health Promotion at School
Miglioretti, Massimo; Velasco, Veronica; Celata, Corrado; Vecchio, Luca
2013-01-01
Objectives: The study explores the relationships among teachers' health representations, their ideas about health promotion, their working conditions and their involvement in health-promotion activities at school. Methods: A questionnaire was administered to 107 teachers in 86 schools in Milan (Italy). The questionnaire was structured in four…
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DEFF Research Database (Denmark)
Mehlsen, Camilla; Jensen, Hans Siggaard
2003-01-01
Managing through Variety: The European Style. 3rd European Academy of Management (EURAM) Conference , Milan (Italy). 2003 Short description: This paper focuses on the use of art metaphors in today?s world of management and organizational practice. Abstract: This paper focuses on the use of art me...
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Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group
Sardanelli, Francesco; Boetes, Carla; Borisch, Bettina; Decker, Thomas; Federico, Massimo; Gilbert, Fiona J.; Helbich, Thomas; Heywang-Köbrunner, Sylvia H.; Kaiser, Werner A.; Kerin, Michael J.; Mansel, Robert E.; Marotti, Lorenza; Martincich, Laura; Mauriac, Louis; Meijers-Heijboer, Hanne; Orecchia, Roberto; Panizza, Pietro; Ponti, Antonio; Purushotham, Arnie D.; Regitnig, Peter; del Turco, Marco Rosselli; Thibault, Fabienne; Wilson, Robin
2010-01-01
The use of breast magnetic resonance imaging (MRI) is rapidly increasing. EUSOMA organised a workshop in Milan on 20-21st October 2008 to evaluate the evidence currently available on clinical value and indications for breast MRI. Twenty-three experts from the disciplines involved in breast disease
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Czech Academy of Sciences Publication Activity Database
Procházka, Libor; Kropáček, Martin; Bašta, Jiří; Melichar, František
2012-01-01
Roč. 39, P0310 (2012), S411-S411 ISSN 1619-7070. [25th Annual Congress of the European-Association-of-Nucelar Medicine. 27.10.2012-31.10.2012, Milan] Institutional support: RVO:61389005 Keywords : radiodiagnostic Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders
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FEDERICO BORROMEO E I «RAGIONAMENTI» INTORNO ALLA «FESTA DELLE LINGUE»
Directory of Open Access Journals (Sweden)
Edoardo Buroni
2017-03-01
Full Text Available Figura di spicco della Milano secentesca, il cardinale Federico Borromeo resta legato nell’immaginario collettivo al personaggio del capolavoro manzoniano, mentre più limitati e più recenti sono gli studi che ne hanno analizzato direttamente l’ampia produzione scrittoria. Particolare interesse rivestono in questo senso i Sacri ragionamenti, le prediche tenute dall’arcivescovo e da lui stesso raccolte in lingua italiana, di cui qui si propone un breve studio relativamente alle omelie pentecostali. «Reasoning» regarding the «festival of languages» in 17th century Milan. Notes on the thought and language of Federico Borromeo A leading figure in 17th century Milan, Cardinal Federico Borromeo remains tied to the character in Manzoni's masterpiece in the collective imagination, while fewer, more recent studies have directly analyzed his written production. Of special interest in this regard are his Sacred writings, the sermons given by the Archbishop which he himself collected in Italian. We propose a brief study of the Pentecostal sermons.
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Directory of Open Access Journals (Sweden)
Sanja Petrović Todosijević
2017-09-01
Full Text Available This paper attempts to illustrate the role the municipal authorities in Šabac, which were headed by wartime mayor Branko Petrović, and which were part of Milan Aćimović’s collaborationist administration and Milan Nedić’s government, played in the process of usurping the right to property of the Jewish people from Šabac and from the Kladovo Transport, initially through the Committee for Registration and Evaluation of Jewish Property, and later through the Commissariat for Jewish Property. Article received: May 2, 2017; Article accepted: May 8, 2017; Published online: September 15, 2017 Original scholarly paper How to cite this article: Petrović Todosijević, Sanja. "Holocaust With(out Bullets: The Public and Property of the Jewish People from Šabac and the Kladovo Transport 1941–1944." AM Journal of Art and Media Studies 13 (2017: 5-15. doi: 10.25038/am.v0i13.181
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Le carte del monastero di S. Maria di Chiaravalle milanese. Additiones documentarie (secolo XII
Directory of Open Access Journals (Sweden)
Maria Cristina Piva
2013-01-01
Full Text Available Founded in 1135 in the immediate outskirts of Milan, Cistercian monastery of S. Maria di Chiaravalle was one of the most important ecclesiastical institutions in Lombardy. Since its foundation, it has played a prominent role in the political, religious, social and economic life of the city. In the Middle Ages the abbey distinguished itself with intensive production and preservation of documents, exemplified nowadays by the several hundreds of charterse preserved in the Archivio di Stato of Milan. This research aims to complete the organic reconstruction work, recently carried out by Anna Maria Rapetti and Ada Grossi regarding the XII century tabularium of Chiaravalle, with the critical edition of 28 unreleased documents dated between 1106 and 1164. In the introduction, in addition to the presentation of the documents, a paragraph will outline the historiographical balance of the studies conducted so far on the abbey.
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Simulation Study of Discharging PCM Ceiling Panels through Night - time Radiative Cooling
DEFF Research Database (Denmark)
Bourdakis, Eleftherios; Kazanci, Ongun Berk; Grossule, F.
2016-01-01
demand. In the present simulation study, the coupling of nighttime radiative cooling with PCM for cooling an office room was investigated. For cooling water through nighttime radiative cooling two types of solar panels were utilized, an unglazed solar collector and photovoltaic/thermal (PV/T) panels...... provided by the PV/T panels was 43 W/m2 for Copenhagen, while for Milan and Athens it was 36 W/m2 and 34 W/m2, respectively. The cooling power of the unglazed solar collector was negligible. Finally, the total electricity produced in Copenhagen for the simulated period was 371 kWh, while for Milan...... and increase use of renewable energy sources. The aim is that by 2020 all new buildings should be nearly zero-energy buildings. A solution that could contribute to this is the combination of photovoltaic panels for the production of electricity and phase change material (PCM) for the reduction of peak cooling...
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Super and ferric: the first HL-LHC component is ready
Antonella Del Rosso
2016-01-01
Although the actual installation phase in the tunnel will only start in 2024, the first magnet – a sextupole – of the High-Luminosity LHC (HL-LHC) is ready and working according to specifications. This first component is also rather unique as, unlike the superconducting magnets currently used in the LHC, it relies on a “superferric” heart. An expert in the LASA Laboratory (INFN Milan, Italy) works on assembling the first sextupole corrector of the HL-LHC. (Image: INFN Milan) Although the name might sound completely unfamiliar, superferric magnets were first proposed in the 1980s as a possible solution for high-energy colliders. However, many technical problems had to be overcome before the use of superferric magnets could become a reality. In its final configuration, the HL-LHC will have 36 superferric corrector magnets, of which 4 will be quadrupoles, 8 sextupoles and 24 higher order magnets. In superferric (or “iron-dominated”) magne...
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Directory of Open Access Journals (Sweden)
Ughi N
2016-03-01
Full Text Available Nicola Ughi, Chiara Crotti, Francesca Ingegnoli Division of Rheumatology, Department of Clinical Sciences and Community Health, Gaetano Pini Institute, The University of Milan, Milan, Italy Abstract: Digital ulcers (DUs are a severe and frequent clinical feature of patients with systemic sclerosis (SSc. The presence of DUs may cause severe pain and often lead to impairment of patient’s functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due to pain may be associated with a negative outcome of DU healing. Therefore, pain management has a key role in patients with SSc. These two case reports describe the effectiveness and safety of oxycodone/naloxone in patients with SSc complicated by painful chronic DUs. Such a therapy has provided pain relief and consequently an increased compliance during redressing wounds. Keywords: oxycodone, naloxone, systemic sclerosis, pain, digital ulcer, scleroderma, analgaesia, wound healing, opioids, calcinosis, UCLA-SCTC GIT 2.0
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/sup 123/I production at the Milan AVF cyclotron
Energy Technology Data Exchange (ETDEWEB)
Acerbi, E; Birattari, C; Castiglioni, M; Resmini, F [Milan Univ. (Italy). Istituto di Fisica
1976-01-01
A program is described to make available quantities of at least 20 mCi of /sup 123/I per irradiation, on a weekly routine basis to medical users at the Clinical Physiology Laboratory of Pisa. Contaminants such as /sup 124/I should be kept below 3%. The isotope, or compounds of it, like iodo-antipyrine and ortho-iodohippuric acid, were to be used as scanning agents for pancreas, kidneys, thyroid and for the detection of the aqueous content in the pulmonary region. The production of /sup 123/I from enriched /sup 124/Te is described. Preliminary experiments on a distillation separation of iodine from the Te target have been performed and the method seems promising in comparison to the time-consuming chemical separation technique.
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Excursion to Milan with Cisalpino and Carlson Wagonlit Travel
2009-01-01
Special offer for CERN staff and their family. Offer valid: - from 20th May to 12th July 2009 (last return) - only in first class - on direct trains from Geneva or Lausanne Return price per person: CHF 146.00 from Geneva CHF 130.00 from Lausanne Conditions : - reservation only via Carlson Wagonlit Travel, CERN - return reservation compulsory - reservation at least 3 days before departure - tickets are not changeable and not refundable - CWT agency fee not included: CHF 25.00 per order - maximum 4 persons per order - no other reduction possible - limited number of seats Enjoy your lunch in an exclusive and traditional place : in the 1st floor of "Zucca in Galleria" http://www.caffemiani.it EUR 44.00 per person (instead of about 80 Euros) Included: Aperitif, antipasti, main dish, dessert, wine/water, coffee. (Closed on Mondays) Reservation: mailto:business@cisalpino.com
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Evaluation of 177Lu-nimotuzumab for Targeted Radioimmunotherapy of EGFR Expressing Tumors
Czech Academy of Sciences Publication Activity Database
Beckford, Denis R.; Balogh, L.; Postenyi, Z.; Mathe, D.; Eigner, Sebastian; Eigner-Henke, Kateřina; Montana, R. L.; Melichar, František
2012-01-01
Roč. 39, P0089 (2012), S327-S327 ISSN 1619-7070. [25th Annual Congress of the European-Association-of-Nucelar Medicine. 27.10.2012-31.10.2012, Milan] Institutional support: RVO:61389005 Keywords : radiotherapy * tumor treatment Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders
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Czech Academy of Sciences Publication Activity Database
Janda, Jozef; Roosje, P.; Marti, E.
2013-01-01
Roč. 68, S1 (2013), s. 341-341 ISSN 0105-4538. [World Allergy and Asthma Congress of the European Academy of Allergy and Clinical Immunology and World Allergy Organization. 22.07.2013-26.07.2013, Milan] Institutional support: RVO:67985904 Keywords : recurrent urticaria Subject RIV: EC - Immunology
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77 FR 49432 - 36(b)(1) Arms Sales Notification
2012-08-16
... military modernization program. The Javelin system will replace the Belgian Army's existing MILAN missile system. The proposed sale of the missiles and support will not alter the basic military balance in the... logistics support. (iv) Military Department: Army (WDM) (v) Prior Related Cases, if any: None (vi) Sales...
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A Fruitful Exchange/Conflict: Engineers and Mathematicians in Early Modern Italy
Maffioli, Cesare S.
2013-01-01
Exchanges of learning and controversies between engineers and mathematicians were important factors in the development of early modern science. This theme is discussed by focusing, first, on architectural and mathematical dynamism in mid 16th-century Milan. While some engineers-architects referred to Euclid and Vitruvius for improving their…
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Leonardi, Matilde; Raggi, Alberto; Antozzi, Carlo; Confalonieri, Paolo; Maggi, Lorenzo; Cornelio, Ferdinando; Mantegazza, Renato
2009-01-01
The objective of this study is to describe functional profiles of patients with myasthenia gravis (MG), and the relationships among symptoms, activities and environmental factors (EF), by using WHO's International Classification of Functioning Disability and Health (ICF). Patients were consecutively enrolled at the Besta Institute of Milan, Italy.…
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Nedožité devadesátiny Milana Otáhala
Czech Academy of Sciences Publication Activity Database
Tůma, Oldřich
2017-01-01
Roč. 24, 1/2 (2017), s. 247-251 ISSN 1210-7050 Institutional support: RVO:68378114 Keywords : Milan Otáhal * obituary * historiography Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)
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RETHINKING ROMANZO ROSA: THE FIRST PERSON NARRATOR ...
African Journals Online (AJOL)
User
marketing strategy elaborated during the interwar years and now in full ... For a comprehensive analysis of romanzo rosa, see also Pozzato (1982) and ... position of capturing the changing social climate and women's search for ... its name into Annabella in 1938, as a consequence of the campaign against ...... Milan: Net.
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Directory of Open Access Journals (Sweden)
Papaleo E
2014-06-01
Full Text Available Enrico Papaleo,1 Carlo Alviggi,2 Giorgio Lorenzo Colombo,3,4 Claudio Pisanelli,5,6 Claudio Ripellino,7 Salvatore Longobardi,8 Pier Luigi Canonico91Centro Scienze della Natalità, Gynecological-Obstetrics Department, San Raffaele Hospital, Vita-Salute San Raffaele, Milan, Italy; 2Department of Neuroscience, Reproductive Sciences and Odontostomatology, University “Federico II” of Naples, Naples, Italy; 3Department of Drug Sciences, University of Pavia, Pavia, Italy; 4SAVE Studi Analisi Valutazioni Economiche, Milan, Italy; 5ACO San Filippo Neri, Rome, Italy; 6Società Italiana Di Farmacia Ospedaliera, Milan, Italy; 7CSD Medical Research Srl, Milan, Italy; 8Medical Department, Merck Serono SpA, Rome, Italy; 9Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy Background: Hypogonadotropic hypogonadal women are characterized by ovarian functionality deficiency, caused by low concentrations of follicle-stimulating hormone (FSH and luteinizing hormone (LH. To recover reproduction functionality, recommended therapies for ovarian induction involve injections of FSH and LH medications. Objective: Since important differences exist between recombinant and urinary gonadotropin therapies in terms of efficacy and cost, the objective of this study was to develop a cost-effectiveness model to compare recombinant FSH (rFSH + recombinant LH (rLH and highly purified human menopausal gonadotropin (HP-HMG. Methods: A Markov model was developed, considering three cycles of therapy; probability of pregnancy and miscarriage were considered, and the efficacy was evaluated in terms of pregnancy occurrence. The perspective of the model was that of the Italian Health Service, so only direct cost (drugs, specialist visits, patient examinations, and hospitalizations were included. Results: rFSH + rLH is associated with a higher total cost (€3,453.50 and higher efficacy (0.87 compared with HP-HMG (€2,719.70 and 0.50. rFSH + r
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78 FR 41993 - Ann Arbor Railroad, Inc.-Lease Exemption-Norfolk Southern Railway Company
2013-07-12
... number of carloads interchanged with NSR in a given year.\\1\\ AARR states that the interchange commitment..., Canadian National Railway Company (CN), CSX Transportation, Inc., and Wheeling & Lake Erie Railway in Toledo; the Indiana and Ohio Railway and CN in Diann, Mich.; NSR in Milan, Mich.; and Great Lakes Central...
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Bruno Munari and the invention of modern graphic design in Italy, 1928-1945
Colizzi, Alessandro
2011-01-01
This study examines Bruno Munari’s work as a graphic designer from the late 1920s to mid-1940s, with the aim of understanding the emergence and characteristics of the modernist trend in Italian graphic design. Taking shape in Milan, an original ‘design culture’ eclectically brought together two
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McAllen, I.; Borgo, E.; Violani, C.
2005-01-01
An attempt is made to reconstruct the trail of a collection of birds from the Solomon Islands to museums in Genoa (Museo Civico di Storia Naturale “G. Doria”, Genova), Turin (Museo Regionale di Scienze Naturali, Torino) and Milan (Museo Civico di Storia Naturale, Milano), Italy, with the aid of
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Unusta, säilita, mäleta : kunstnikud materialiseerivad mälu / Laura Põld
Põld, Laura, 1984-
2015-01-01
Rahvusvaheline näitus "Tracing the Memory" Vaal galeriis 17. detsembrist 2014 kuni 17. jaanuarini 2015, kuraatorid Annika Toots ja Slavomira Ondrušová. Eksponeeriti Daniela Krajčová, Jan Nálevka, Katarina Poliačiková, Laura Tootsi ja Milan Vagač'i installatsioone. Kunstnike eluloolisi andmeid
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Collective memory and the Casa della Memoria : on the potential and risk of instant patina
Black, S.E.; Jenniskens, D.P.H.
2017-01-01
This article investigates the way in which instant patina is employed in the Casa della Memoria (House of Memory) in Milan by Baukuh (2015), with reference to Maurice Halbwachs’s theory of collective memory. It observes that the Casa della Memoria uses instant patina with the aim of solidifying a
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Proper comparison among methods using a confusion matrix
CSIR Research Space (South Africa)
Salmon
2015-07-01
Full Text Available -1 IGARSS 2015, Milan, Italy, 26-31 July 2015 Proper comparison among methods using a confusion matrix 1,2 B.P. Salmon, 2,3 W. Kleynhans, 2,3 C.P. Schwegmann and 1J.C. Olivier 1School of Engineering and ICT, University of Tasmania, Australia 2...
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DEFF Research Database (Denmark)
Thomsen, M.R.
2001-01-01
Fremlæggelse af en tese om, at en række værker med vilje har en overflod af referencer - til forfatteren, til historien - for at skjule betydningen af dette. Inddragelse af værker af Svend Åge Madsen, J. P. Jacobsen, Milan Kundera og Jorge Luis Borges....
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Roberts, Janine; And Others
1989-01-01
Describes process that six counselor trainees and two supervisors used with treatment and observation teams to examine their own coevolution as a therapeutic system using the Milan model of family therapy and Ericksonian hypnotherapy. Concludes with a discussion of advantages and pitfalls of this type of dual supervision. (Author/ABL)
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Diurnal, weekly and seasonal air concentrations of PCDD and PCDF in an industrial area
International Nuclear Information System (INIS)
Benfenati, E.; Mariani, G.; Schiavon, G.; Lodi, M.; Fanelli, R.
1994-01-01
Air samples were collected in an industrial area close to Milan in July and in November, day and night for five days and have been analyzed for PCDD and PCDF. Average summer levels were generally lower than winter levels, and average concentrations were higher by night than by day in both months. (orig.)
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2017-2018 Travel Expense Reports for Dominique Corti, Governor
International Development Research Centre (IDRC) Digital Library (Canada)
SD
Purpose: Board Meetings. Date(s):. 2017-06-17 to 2017-06-22. Destination(s):. Ottawa. Airfare: $7,276.00. Other. Transportation: $83.53. Accommodation: $542.78. Meals and. Incidentals: $155.50. Other: $0.00. Total: $8,057.81. Comments: From residence in Milan, Italy. 2017-2018 Travel Expense Reports for. Dominique ...
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2017-2018 Travel Expense Reports for Dominique Corti, Governor
International Development Research Centre (IDRC) Digital Library (Canada)
Lorena Marrero
Purpose: Board Meetings. Date(s):. 2017-11-19 to 2017-11-24. Destination(s):. Ottawa. Airfare: $6,660.28. Other. Transportation: $38.93. Accommodation: $851.24. Meals and. Incidentals: $309.42. Other: $0.00. Total: $7,859.87. Comments: From residence in Milan, Italy. 2017-2018 Travel Expense Reports for. Dominique ...
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Breaking the Patriarchal Vision of Social Science: Lessons from a Family Therapy Model.
McNamee, Sheila
The Milan model of systemic family therapy, developed in Italy and based on G. Bateson's cybernetic epistemology, can help meet the goals of a feminist/systemic epistemology in research by accepting data in its "traditional" form yet also connecting it to the act of researching, itself, thereby merging a feminist perspective with the…
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International Nuclear Information System (INIS)
Barca, Donatella; Comite, Valeria; Belfiore, Cristina M.; Bonazza, Alessandra; La Russa, Mauro F.; Ruffolo, Silvestro A.; Crisci, Gino M.; Pezzino, Antonino; Sabbioni, Cristina
2014-01-01
Highlights: • Geochemical study of black crusts developed on three monuments located in Milan, Florence and Rome. • Trace element composition of the black crusts is greatly influenced by anthropogenic pollution. • Geochemical characterization of black crusts can be used as a reliable indicator of environmental pollution. - Abstract: This work presents results from a petrographic, morphological and chemical study of the black crusts developing on monuments in three Italian cities, the Cathedral of Milan, the Cathedral of St. Maria del Fiore in Florence, and the Vittoriano Monument in Rome. Black crusts (BCs) were studied with traditional techniques such as optical microscopy (OM), scanning electron microscopy coupled with energy-dispersive X-ray spectrometry (SEM-EDS) and infrared spectroscopic techniques (FT-IR), in combination with laser ablation inductively coupled mass spectrometry (LA-ICP-MS), which has shown itself to be particularly useful in determining concentrations of heavy metals in BCs. Although the BCs of the three monuments show general enrichment in heavy metals with respect to the substrate (S), interesting differences were observed among them. The BCs from Milan are the richest in heavy metals, particularly Pb and Zn, reflecting the severe air pollution of this very large city, which, in addition to its intense traffic, is located in the most highly industrialized area of Northern Italy. The BCs from the south-eastern side of the Cathedral of St. Maria del Fiore in Florence, facing a pedestrian area, show little enrichment in heavy metals, and those from the Vittoriano Monument in Rome, which is exposed to intense road traffic, display variable enrichment, attributable to mobile emission sources. Results show that the various enrichment trends in heavy metals observed in the BCs of these three monuments are due to many factors: various sources of anthropogenic pollution, sampling height, exposure, orientation, and the shape of the deposition
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Designing a Strategic Plan through an Emerging Knowledge Generation Process: The ATM Experience
Zanotti, Francesco
2012-01-01
Purpose: The aim of this contribution is to describe a new methodology for designing strategic plans and how it was implemented by ATM, a public transportation agency based in Milan, Italy. Design/methodology/approach: This methodology is founded on a new system theory, called "quantum systemics". It is based on models and metaphors both…
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Periventricular Nodular Heterotopia and Epilepsy
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2006-02-01
Full Text Available The clinical, MRI, and EEG findings in 54 patients (35 female, 19 male; aged 1 to 64 years with periventricular nodular heterotopia (PNH were analyzed in relation to epileptic outcome and genesis of epileptic discharges, in a study at the Neurological Institute and Epilepsy Surgery Center, Niguarda General Hospital, Milan, Italy.
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An Analysis of Students Enrolled to an Undergraduate University Course Offered Also Online
Scarabottolo, Nello
2016-01-01
This paper analyzes the main characteristics of the students enrolled to a three-years undergraduate course on Security of Computer Systems and Networks, offered in traditional, classroom based fashion as well as online at the University of Milan (Italy). This allows to compare classroom and online students from several points of view, and gives…
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Total error vs. measurement uncertainty: revolution or evolution?
Oosterhuis, Wytze P; Theodorsson, Elvar
2016-02-01
The first strategic EFLM conference "Defining analytical performance goals, 15 years after the Stockholm Conference" was held in the autumn of 2014 in Milan. It maintained the Stockholm 1999 hierarchy of performance goals but rearranged them and established five task and finish groups to work on topics related to analytical performance goals including one on the "total error" theory. Jim Westgard recently wrote a comprehensive overview of performance goals and of the total error theory critical of the results and intentions of the Milan 2014 conference. The "total error" theory originated by Jim Westgard and co-workers has a dominating influence on the theory and practice of clinical chemistry but is not accepted in other fields of metrology. The generally accepted uncertainty theory, however, suffers from complex mathematics and conceived impracticability in clinical chemistry. The pros and cons of the total error theory need to be debated, making way for methods that can incorporate all relevant causes of uncertainty when making medical diagnoses and monitoring treatment effects. This development should preferably proceed not as a revolution but as an evolution.
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The mitochondrial genome, a growing interest inside an organelle
Directory of Open Access Journals (Sweden)
Marco Crimi
2008-03-01
Full Text Available Marco Crimi1, Roberta Rigolio21National Institute of Molecular Genetics (INGM, Functional Genomics Unit, Milan, Italy; 2Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, ItalyAbstract: Mitochondria are semi-autonomously reproductive organelles within eukaryotic cells carrying their own genetic material, called the mitochondrial genome (mtDNA. Until some years ago, mtDNA had primarily been used as a tool in population genetics. As scientists began associating mtDNA mutations with dozens of mysterious disorders, as well as the aging process and a variety of chronic degenerative diseases, it became increasingly evident that the information contained in this genome had substantial potential applications to improve human health. Today, mitochondria research covers a wide range of disciplines, including clinical medicine, biochemistry, genetics, molecular cell biology, bioinformatics, plant sciences and physiology. The present review intends to present a summary of the most exiting fields of the mitochondrial research bringing together several contributes in terms of original prospective and future applications.Keywords: mtDNA, heteroplasmy, molecular diagnostics, mitochondriopathies, nanogenomics
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Formalized Combined 2003 European Guidelines on Cardiovascular Disease Prevention and Hypertension
Czech Academy of Sciences Publication Activity Database
Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana
23 Suppl. 2, - (2005), s. 196 ISSN 0263-6352. [European Meeting on Hypertension /15./. 17.06.2005-21.06.2005, Milan] R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : European medical guidelines * formalization of combined guidelines Subject RIV: FA - Cardiovascular Disease s incl. Cardiotharic Surgery
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Lingua franca in Central Europe after the Disappearance of German
Snel, G.
2012-01-01
This chapter discusses a multilingual community of writers and intellectuals who gathered around the idea of a Central European culture in the 1980s, during the last decade of the Cold War. Czesław Miłosz, Danilo Kiš, Milan Kundera, György Konrád and others advocated the idea of a Central European
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Treatment Algorithm of a Hypertension Specialist
Czech Academy of Sciences Publication Activity Database
Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt; Zvárová, Jana
2007-01-01
Roč. 25, Suppl. 2 (2007), S 383-S 383 ISSN 0952-1178. [European Meeting on Hypertension /17./. 15.06.2007-19.06.2007, Milan] R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : treatment algorithm for hypertension * hypertension specialist Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
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Hypertension and other Risk Factors of Atherosclerosis in the Czech Population
Czech Academy of Sciences Publication Activity Database
Tomečková, Marie; Grünfeldová, H.; Peleška, Jan; Hanuš, P.; Marušiaková, Miriam
2007-01-01
Roč. 25, Suppl. 2 (2007), S 353-S 353 ISSN 0952-1178. [European Meeting on Hypertension /17./. 15.06.2007-19.06.2007, Milan] R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : atherosclerosis * risk factors * hypertension Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
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Interoperabilità fra VULCANO e Borsa Lavoro
Ballardini, Luigi; Benedetti, Giovanbattista; Trombetta, Laura
2006-01-01
We briefly describe a project, in the definition phase, between the University of Milan-Bicocca, CILEA and Borsa Lavoro Lombardia (BLL), for the diffusion of information necessary to match job offers and requests. We aim to realise an interexchange and cooperation channel that allows the integration of the databases of the university with that of BLL.
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The Urban Development of Milan in the Early Christian Age
Directory of Open Access Journals (Sweden)
Marco Sannazaro
2015-06-01
Full Text Available Molte testimonianze di contemporanei descrivono le vicende che hanno interessato Milano in età paleocristiana e integrano il quadro offerto dai resti archeologici e dai monumenti superstiti. Ciò nonostante, la ridefinizione in senso cristiano del paesaggio urbano emerge più chiaramente solo con l’età ambrosiana, mentre risulta assai difficile chiarire i precedenti progressi della cristianizzazione e in particolare il contributo di Costantino e dei suoi figli. Essi sono forse intervenuti nell’organizzazione del cimitero ad martyres, principale polo cultuale extramuraneo, ma ignoriamo se ad essi possono essere ricondotti altri interventi edilizi tesi a modificare l’impianto urbanistico di età massimianea.
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Directory of Open Access Journals (Sweden)
Roberto A
2017-09-01
Full Text Available A Roberto,1 MT Greco,2 L Legramandi,3 F Galli,3 M Galli,4 O Corli1 1Pain and Palliative Care Research Unit, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, 2Department of Clinical Sciences and Community, University of Milan, Milan, Italy, 3Methodology for Clinical Research Laboratory, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, 4Scientific Medical Communication srl, Novara, Italy Background: Opioids are the most important pharmacological treatment for moderate-to-severe cancer pain, but side effects limit their use. Transdermal fentanyl (TDF and oral prolonged-release oxycodone-naloxone (OXN-PR are effective in controlling chronic pain, with less constipation compared to other opioids. However, TDF and OXN-PR have never been directly compared.Patients and methods: Cancer patients with moderate-to-severe chronic pain were consecutively enrolled in two prospective 28-day trials, received either TDF or OXN-PR, and were assessed at baseline and after 7, 14, 21, and 28 days. The primary endpoint was 28-day analgesic response rate (average pain intensity decrease ≥30% from baseline. Other outcome measures included opioid daily dose changes over time; need for adjuvant analgesics; number of switches; premature discontinuation; presence and severity of constipation; and other adverse drug reactions. To compare the efficacy and the safety of TDF and OXN-PR, we used the propensity score analysis to adjust for heterogeneity between the two patient groups.Results: Three hundred ten out of 336 patients originally treated (119 TDF and 191 OXN-PR were included in the comparative analysis. The amount of responders was comparable after TDF (75.3% and OXN-PR administration (82.9%, not significant [NS]. The final opioid daily dose expressed as morphine equivalent was 113.6 mg for TDF and 44.5 mg for OXN-PR (p<0.0001. A daily opioid dose escalation >5% was less common after
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L'espansione della criminalità organizzata nell'attività di impresa al Nord
Directory of Open Access Journals (Sweden)
Alberto Alessandri
2016-12-01
Full Text Available La presente ricerca, realizzata nell’ambito del Dipartimento di Studi Giuridici dell’Università Bocconi di Milano, si è proposta lo scopo di accertare empiricamente l’attività di contrasto all’infiltrazione mafiosa nelle attività economiche da parte della Procura e del Tribunale di Milano, nel periodo 2000 – 2015. Sono stati consultati, nella loro interezza, tutti i fascicoli dei procedimenti penali aperti (e accessibili nel periodo e per i quali vi sia stato un provvedimento di chiusura delle indagini preliminari. Poi è stata sono stati seguiti i processi fino in Cassazione. Sono stati inoltre considerati i fascicoli e i provvedimenti definitivi emessi dal Tribale di Prevenzione di Milano, riferiti allo stesso arco temporale, con attenzione centrata alle misure patrimoniali. Si è dato conto anche dei flussi dei procedimenti riguardanti aventi ad oggetto l’art. 416-bis c.p., oltre che del Tribunale di Milano, di quelli di Roma, Napoli, Reggio Calabria, Palermo. I dati ricavati dai fascicoli sono stati elaborati con un apposito software, per ottenere le correlazioni e le statistiche ritenute di maggior interesse, in specie riguardo alla penetrazione nel settore economico e imprenditoriale. Parole chiave: mafia; criminalità organizzata; ‘ndrangheta; attività economiche; Italia settentrionale. This research, conducted within the Department of Law of Bocconi University in Milan, aims to empirically ascertain the actions implemented by the Office of the Public Prosecution and the Court of Milan to counteract the Mafia’s infiltration in economic activities in the period from 2000 to 2015. All the records pertaining to criminal proceedings opened (and accessible in the relevant period - and in relation to which preliminary investigations were closed - were consulted in their entirety. The proceedings were then followed up until the Court of Cassation. In addition, all the records and final decisions issued by the Tribunale di
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A perspective on the U.S. economic outlook and monetary policy
Charles I. Plosser
2013-01-01
Presented by Charles I. Plosser, President and Chief Executive Officer, Federal Reserve Bank of Philadelphia, Global Interdependence Center's Central Banking Series: Recovery 2013 — Strength or Stagnation?, Milan, Italy, May 16, 2013 ; Note: President Plosser presented similar remarks on May 14, 2013, before the SNS (Center for Business and Policy Studies) and the SIFR (The Institute for Financial Research) in Stockholm, Sweden.
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Journal of Biosciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Journal of Biosciences; Volume 36; Issue 1. P1 peptidase – a mysterious protein of family Potyviridae. Jana Rohožková Milan Navrátil ... The coding region for P1 peptidase is located at the very beginning of the viral genome of the family Potyviridae. Until recently P1 was thought of as serine peptidase with ...
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Don Davide Albertario propagandista antiebraico. L'accusa di omicidio rituale
Directory of Open Access Journals (Sweden)
Annalisa Di Fant
2011-05-01
Full Text Available The article analyses the leading role played by the priest/journalist Davide Albertario in the catholic antisemite propaganda of the late 19th century. He was director of "L'Osservatore Cattolico", a Milan-based daily paper belonging to the catholic press network controlled by the Vatican, that published many articles against the Jews, notably involving the blood libel.
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Nitric oxide synthase isoforms in spontaneous and salt hypertension
Czech Academy of Sciences Publication Activity Database
Hojná, Silvie; Kuneš, Jaroslav; Zicha, Josef
2007-01-01
Roč. 25, Suppl. 2 (2007), S 338-S 338 ISSN 0263-6352. [European Meeting on Hypertension /17./. 15.06.2007-19.06.2007, Milan] R&D Projects: GA MŠk(CZ) 1M0510 Institutional research plan: CEZ:AV0Z50110509 Keywords : nitric oxide synthase isoforms * spontaneous and salt hypertension Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
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Funding fears spark Italian protests
Abbott, A
2001-01-01
150 Italian scientists took part in a symbolic funeral in Milan for Italian research. Scientists are worried that the new government will reduce support for basic research. Rumours that budgets will be cut are being confirmed and last week the government rejected the 3-year plan of the National Research Council, which had proposed an expansion of staff (1/2 page).
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6/sup +/ isomer state in /sup 46/Ca
Energy Technology Data Exchange (ETDEWEB)
Bizzeti, P G; Maurenzig, P R; Poggi, G [Florence Univ. (Italy). Istituto di Fisica; Lo Bianco, G [Milan Univ. (Italy). Istituto di Fisica
1975-01-11
The decay of the expected isomer, obtained from the reaction /sup 48/Ca(p,p2n)/sup 46/Ca, has been observed as a delayed activity after bombardment of a 97.2% enriched /sup 48/CaC0/sub 3/ target with 35 MeV protons. The experimental apparatus used at AUF cyclotron of Milan is described. Data are reported and discussed.
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Gesti convenzionali e arte mimica nell’Ottocento italiano
Directory of Open Access Journals (Sweden)
Noemi Massari
2015-03-01
Full Text Available The present essay aims at reviewing the issues and methodologies faced in my PhD research. The first step will be the analysis of the theoretical assumptions that underlie the emergence of ballet pantomime and the rediscovery of classical pantomime. The essay will proceed outlining the artistic and cultural landscapes of the two Italian cities examined, Milan and Naples, aiming at defining, from a didactic viewpoint, the teaching of pantomime in the two largest Italian academies, the Teatro alla Scala in Milan and the Teatro di San Carlo in Naples. The third step will be the recording of the few references to the mime art contained in the treaties and documents relating to the dance in Italy during the Nineteenth century (Carlo Blasis, Vincenzo Buonsignori, Giulio Pompeo Ferrario. These references will be compared to the major mime treatises for actors (Giovanni Emanuele Bideri, Antonio Morrocchesi, Angelo Canova, Alemanno Morelli and opera singers (Manuel Garcia, Fernando Pelzet, Leone Giraldoni, Enrico Serafino Torelli, Augusto Delle Sedie in order to analyze the development of gesture during the Nineteenth century and the different use that each interpreter did of the expressive mime.
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"Tools" for the Development of the Inspection Activity in Archaeological Sites
Directory of Open Access Journals (Sweden)
Susanna Bortolotto
2015-05-01
Full Text Available One of the acquisitions of contemporary conservation philosophy is precisely this: you don’t restore the image but the matter of the work; restoration is first and foremost the conservation of the work’s authenticity. The task of conservation is not returning to an impossible past but rather enabling the work to be handed down to the future. From this standpoint, in today’s conservation language we speak of conservation: guaranteeing through our efforts that the work entrusted to us will still be available for the future, for ourselves and the generations to come, eliminating or slowing down the causes of deterioration that endanger it so that it can be enjoyed and used. The project, "Milan Archaeology for Expo 2015. Towards a valorization of the archaeological heritage of the city", intends - respect to these theoretical and methodological - to develop processes of knowledge and planned conservation of urban archaeological areas with coordinated maintenance actions, promotion and communication of the different sites present in Milan historic centre. All this sites will be connected in a network system built for a larger project that it will increase the accessibility and enhancement.
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International Nuclear Information System (INIS)
Cogliani, E.
2001-01-01
There are many different air pollution indexes which represent the global urban air pollution situation. The daily index studied here is also highly correlated with meteorological variables and this index is capable of identifying those variables that significantly affect the air pollution. The index is connected with attention levels of NO 2 , CO and O 3 concentrations. The attention levels are fixed by a law proposed by the Italian Ministries of Health and Environment. The relation of that index with some meteorological variables is analysed by the linear multiple partial correlation statistical method. Florence, Milan and Vicence were selected to show the correlation among the air pollution index and the daily thermic excursion, the previous day's air pollution index and the wind speed. During the January-March period the correlation coefficient reaches 0.85 at Milan. The deterministic methods of forecasting air pollution concentrations show very high evaluation errors and are applied on limited areas around the observation stations, as opposed to the whole urban areas. The global air pollution, instead of the concentrations at specific observation stations, allows the evaluation of the level of the sanitary risk regarding the whole urban population. (Author)
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International Nuclear Information System (INIS)
Rossi, L.; Volpini, G.
1991-01-01
The precision of I c measurement of straight superconducting cables in solenoids can be limited by the magnetic field inhomogeneity. A solution in order to improve the field homogeneity based on iron shims is presented here. A conceptual design for the experimental lay-out of a test station to be used in connection with the SOLEMI-I solenoid at the Milan INFN Section (LASA Laboratory) is given
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2015-05-01
Keulmann, and Yara Alejandra Montenegro Pinto, who were students and visiting scientists at the University of Delaware, for their contributions to this...metals content (Al, Fe and Mn), were determined by the soil laboratory at the Plant and Soil Science Department at the University of Table 1...Milan Army Ammunition Plant (MAAP). ERDEC-TR-136. Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD. Coleman NT
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Epilepsy course in cerebral gangliogliomas: a study of 16 cases.
Casazza, M; Avanzini, G; Broggi, G; Fornari, M; Franzini, A
1989-01-01
From November 1979 to March 1988, 16 patients with cerebral gangliogliomas were investigated and underwent surgery at the Institute Neurologico "C. Besta" of Milan. Their age varied from 11 to 48 years. 15 of these patients presented with a seizure as the first and often the only neurological symptom. This report deals with the epileptologic and neuroradiologic features of these patients before and after surgical treatment.
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JPRS Report, Science & Technology, Europe & Latin America.
1988-01-22
INDUSTRIA OGGI in Italian Sep 87 p 85 [Interview with Rinaldo Piva, managing direstor of Ceramica Industriale Fer, by Luisella Acquati: "Italy Is...Piva, the dynamic managing director of Ceramica Industriale Fer, which is based in Seregno, Milan, and which for many years has been conducting...eliminating the polluting content of exhaust gases . Numerous families of ceramics lend themselves advantageously to various applications in motors
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2017-12-01
world, there is some ambiguity when discussing the design of a product , and ambiguity driven by market competition focus on a product’s meanings...constrained interpretation of design . One such case is the Artemide manufacturing company based out of Milan, highly awarded and regarded within the...project was a new design strategy radically divergent from convention, differentiating the product from competing groups while developing new
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Global music approach to persons with dementia: evidence and practice
Raglio, Alfredo; Filippi, Stefania; Bellandi, Daniele; Stramba-Badiale, Marco
2014-01-01
Alfredo Raglio,1,2 Stefania Filippi,2 Daniele Bellandi,3 Marco Stramba-Badiale4 1Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; 2APSP “Margherita Grazioli”, Povo, Trento, Italy; 3Geriatric Department, Sospiro Foundation, Sospiro, Cremona, Italy; 4Department of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico Italiano, Milan, Italy Abstract: Music is an important resource for achieving psychological, co...
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Cazzaniga, R; Francescani, A; Saetti, C; Spinnler, H
2003-11-01
The aim of the present study was to provide a statistically sound way of reciprocally converting scores of the mini-mental state examination (MMSE) and the Milan overall dementia assessment (MODA). A consecutive series of 182 patients with "probable" Alzheimer's disease patients was examined with both tests. MODA and MMSE scores proved to be highly correlated. A formula for converting MODA and MMSE scores was generated.
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Development and psychometric testing of a breast cancer patient-profiling questionnaire
Directory of Open Access Journals (Sweden)
Gorini A
2015-06-01
Full Text Available Alessandra Gorini,1,2 Ketti Mazzocco,1,2 Sara Gandini,2 Elisabetta Munzone,2 Gordon McVie,2 Gabriella Pravettoni1,2 1Department of Health Science, University of Milan, Milan, Italy; 2European Institute of Oncology, Milan, Italy Introduction: The advent of “personalized medicine” has been driven by technological advances in genomics. Concentration at the subcellular level of a patient's cancer cells has meant inevitably that the “person” has been overlooked. For this reason, we think there is an urgent need to develop a truly personalized approach focusing on each patient as an individual, assessing his/her unique mental dimensions and tailoring interventions to his/her individual needs and preferences. The aim of this study was to develop and test the psychometric properties of the ALGA-Breast Cancer (ALGA-BC, a new multidimensional questionnaire that assesses the breast cancer patient's physical and mental characteristics in order to provide physicians, prior to the consultation, with a patient's profile that is supposed to facilitate subsequent communication, interaction, and information delivery between the doctor and the patient. Methods: The specific validation processes used were: content and face validity, construct validity using factor analysis, reliability and internal consistency using test–retest reliability, and Cronbach's alpha correlation coefficient. The exploratory analysis included 100 primary breast cancer patients and 730 healthy subjects. Results: The exploratory factor analysis revealed eight key factors: global self-rated health, perceived physical health, anxiety, self-efficacy, cognitive closure, memory, body image, and sexual life. Test–retest reliability and internal consistency were good. Comparing patients with a sample of healthy subjects, we also observed a general ability of the ALGA-BC questionnaire to discriminate between the two. Conclusion: The ALGA-BC questionnaire with 29 items is a valid
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Seasonal changes in nasal cytology in mite-allergic patients
Directory of Open Access Journals (Sweden)
Gelardi M
2014-03-01
Full Text Available Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs are a major cause of allergic rhinitis (AR and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens
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An ecological time-series study of heat-related mortality in three European cities
Directory of Open Access Journals (Sweden)
Russo Antonio
2008-01-01
Full Text Available Abstract Background Europe has experienced warmer summers in the past two decades and there is a need to describe the determinants of heat-related mortality to better inform public health activities during hot weather. We investigated the effect of high temperatures on daily mortality in three cities in Europe (Budapest, London, and Milan, using a standard approach. Methods An ecological time-series study of daily mortality was conducted in three cities using Poisson generalized linear models allowing for over-dispersion. Secular trends in mortality and seasonal confounding factors were controlled for using cubic smoothing splines of time. Heat exposure was modelled using average values of the temperature measure on the same day as death (lag 0 and the day before (lag 1. The heat effect was quantified assuming a linear increase in risk above a cut-point for each city. Socio-economic status indicators and census data were linked with mortality data for stratified analyses. Results The risk of heat-related death increased with age, and females had a greater risk than males in age groups ≥65 years in London and Milan. The relative risks of mortality (per °C above the heat cut-point by gender and age were: (i Male 1.10 (95%CI: 1.07–1.12 and Female 1.07 (1.05–1.10 for 75–84 years, (ii M 1.10 (1.06–1.14 and F 1.08 (1.06–1.11 for ≥85 years in Budapest (≥24°C; (i M 1.03 (1.01–1.04 and F 1.07 (1.05–1.09, (ii M 1.05 (1.03–1.07 and F 1.08 (1.07–1.10 in London (≥20°C; and (i M 1.08 (1.03–1.14 and F 1.20 (1.15–1.26, (ii M 1.18 (1.11–1.26 and F 1.19 (1.15–1.24 in Milan (≥26°C. Mortality from external causes increases at higher temperatures as well as that from respiratory and cardiovascular disease. There was no clear evidence of effect modification by socio-economic status in either Budapest or London, but there was a seemingly higher risk for affluent non-elderly adults in Milan. Conclusion We found broadly consistent
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“The Milan Papyrus” – Seminal Discovery of New Hellenistic Verses
Directory of Open Access Journals (Sweden)
Jelena Isak Kres
2006-07-01
Full Text Available The publication of some newly discovered poems, probably to be attributed to the Hellenistic epigrammatist Posidippus of Pella, is the most significant recent contribution to the corpus of Greek literature. The sheer amount of the poetry and the light which it sheds on our understanding of the literary period makes it the most important discovery in decades, comparable to the papyrus discoveries of Bacchylides, Menander, and Sappho. Moreover, the text is considered to be the earliest collection of Greek poetry organised on aesthetic principles.
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Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice
2001-08-01
developed more slowly by transgenic FVB Anatomia Patologica, Ospedale S.S. Annunziata, Via Valignani, 66100 female mice carrying the wild-type proto...coopted (Pezzella et al., 1997). Anatomia Patologica. Ospedale SS. Annunziata, Via Valignani, 66100 Chieti, Italy. Fax: 39 0871 330471. E-mail: musiani...lo Studio e la Cura dei Tumori, Milan, Italy; and Reprints: Piero Musiani, G. d’ Annunzio University of Chieti, Anatomia Department of Experimental
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Communication helps development of nuclear energy
International Nuclear Information System (INIS)
Kopriva, A.
2007-01-01
In mid-February more than 170 nuclear energy sector communicators from 24 countries all over the world met in Milan, Italy. This year, the whole agenda dealt with the already known phenomenon of nuclear energy sector renaissance and the need for construction of new nuclear power plants, as a clean source of electricity generation without greenhouse emissions, which forms inseparable part of the energy mix in the world. (author)
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Dietary Habits and Cardiometabolic Health in Obese Children
Gilardini, Luisa; Croci, Marina; Pasqualinotto, Lucia; Caffetto, Katherine; Invitti, Cecilia
2015-01-01
Background Prevalence rates of cardiometabolic risk factors vary largely among overweight children. This study investigated the relationships between dietary habits and cardiometabolic health among obese children living in a city of Northern Italy. Methods Dietary habits were collected in 448 obese subjects aged 6-18 years, attending an obesity outpatient center in Milan. Anthropometry, blood pressure (BP), lipids, fasting and post-load glucose, and insulin were measured. Physical activity wa...
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Dual-Use Applications of Infrared Sensitive Materials
1993-06-01
thermography unit by International Products and Services which is produced in Italy . Two additional systems are now being reviewed by the Japanese government...contact thermography companies. Flexi-Therm of Westbury, NY, a subsidiary of E-Z-EM, Incl, and International Products and Services in Milan, Italy ...shelled pecans and walnuts can be inspected to identify shell fragments that remain. A solenoid can be activated upon recognizing a shell, releasing a
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Palmieri, Giancarlo; Contaldi, Paola; Fogliame, Giuseppe
2017-01-01
Giancarlo Palmieri,1,2 Paola Contaldi,1 Giuseppe Fogliame1 1ANARDI Medical and Scientific Association, Scafati, Italy; 2Department of Internal Medicine, Niguarda Cà Granda Hospital, Milan, Italy Background and purpose: Sleep disturbances and related daytime activities impairment are common diseases nowadays. General practitioners are often the first health care professional asked to alleviate sleep disturbances and primary insomnia symptoms. Beyond a wide class of hypnotic drugs, ...
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CTC Sentinel. Volume 7, Issue 3
2014-03-01
Greece, the United Kingdom, Russia, Mexico, Chile , Argentina, Indonesia and other countries.38 In May 2012, two months before the start of the...universities, immigration detention centers and other targets. In particular, in December 2009 a rudimentary bomb partially exploded at night at Bocconi...University, a prestigious private university in Milan,42 while a letter bomb was sent to an immigration detention center in the northeastern town of
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María Luisa: Delirios de vida y muerte
Directory of Open Access Journals (Sweden)
Juan José Jordán
2015-01-01
Full Text Available Esta propuesta consiste en enjuiciar a través de mi texto dramático María Luisa (Ediciones Unicornio, 2013 a María Luisa Milanés(1893-1919 como figura del Bayamo de la naciente República, que se convierte en figura indiscutible de las letras femeninas cubanas. Tomo como punto de partida su opacado perfil histórico-literario, resultado de un contexto sociocultural hostil, decidido a ignorarla.María Luisa es una invitación, también, para los entendidos en literatura al análisis de un incipiente y malogrado discurso narrativo y un más elaborado discurso lírico. Es una pretensión de rescatar a esta escritora en los‹‹ estudios de género››; que mi texto funcione como marco teórico para una profundización crítica, área que carece de un verdadero juicio literario milanesiano . Es un intento por enriquecer la bibliografía al respecto, con un enfoque sociocultural integrador, donde la proyección intragenérica predominante en la obra de María Luisa Milanés transite desde la historia cultural microsocial hacia el discurso femenino, también conformador de lo nacional.
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The effects of atmospheric multipollutants on modern concrete
Energy Technology Data Exchange (ETDEWEB)
Marinoni, N.; Birelli, M.P.; Rostagno, C.; Pavese, A. [University of Milan, Milan (Italy)
2003-10-01
Concrete samples were collected from the indoor walls of a tunnel in Milan (Italy), erected at the beginning of the 20th century for railway subway. Since the second half of the 20th century, during the construction of Stazione Centrale (Central Railway Station) of Milan, the tunnel has been turned into an automobile and railway crossing, thus increasing the deposition of aggressive pollutants on building materials. Weathering layers (commonly known as black crusts) caused by deposition of atmospheric pollutants on concrete surfaces were analysed in order to investigate the main mechanisms responsible for deterioration. A mineralogical and physical-chemical characterisation of the concrete and black crusts was performed by optical microscopy, atomic absorption spectroscopy, X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. The results attest that the main deterioration phenomenon affecting concrete is the sulphation process by dry deposition, leading to secondary salt crystallisation (gypsum formation) on the external surface of the samples. Moreover, concrete samples show widespread micro- and macro-cracking, high porosity, and corrosion phenomena at the aggregate binder interface (AAR). Airborne particulate matter produced by fuel (oil-derived and coal) combustion was found embedded in the gypsum matrix of black crusts, suggesting its catalytic role in sulphation process.
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Barrio residencial de Gratosoglio, Milán
Directory of Open Access Journals (Sweden)
Giannini, Sandro
1967-04-01
Full Text Available The group of 23 buildings in the residential zone of Gratosoglio, which provide space for 1,000 dwellings, has been built by the firm «Fintech Italcamus». This Italian firms applies in Italy the «Raymond Camus» system, which is a positive aid to heavy prefabrication in housing projects. The above group of buildings constitute part of the General Building Scheme so successfully initiated by the Autonomous Building Institute of the Province of Milan, with the purpose of helping to overcome the extensive lack of housing in the Milan region.El grupo de edificios levantado en el Barrio Residencial de Gratosoglio, Milán (23, con un total de 1.000 viviendas, ha sido construido por la firma «Fintech Italcamus», Sociedad italiana que aplica en Italia el sistema «Raymond Camus» y constituye una aportación positiva de la prefabricación pesada a la edificación residencial. Este conjunto forma parte del Plan General de edificación, emprendido con tanto éxito como acierto por el Instituto Autónomo de la Vivienda de la Provincia de Milán, para solucionar los problemas que la gigantesca presión demográfica planteaba en dicha provincia.
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Decisions and involvement of cancer patient survivors: a moral imperative
Directory of Open Access Journals (Sweden)
Pravettoni G
2016-12-01
Full Text Available Gabriella Pravettoni,1,2 Ilaria Cutica,1,2 Simona Righetti,1 Ketti Mazzocco1,2 1Department of Oncology and Hematology, University of Milan, 2Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology, Milan, Italy Purpose: The aim of this study was to review the experiences of direct involvement in patient survivorship for treatment and research. Methods: This is a narrative-focused review of the following two recent experiences of patient involvement: the Chordoma Foundation and the Triple Negative Breast Cancer Foundation. Results: These two examples represent concrete experiences that patients have built to favor a real involvement in the care and treatment of tumors. These experiences are profoundly modifying how cancer research is conducted and draw attention to the psychosocial dimensions of health care. Conclusion: These examples represent the new scenario in which modern medicine faces completely new challenges, copes with new needs, and cooperates with new health care professionals. Implications: Involving patients in a new perspective raises practical and ethical challenges for organizations to work together, for health providers to be professionally skilled and for the government to promote safeguarding policies. Keywords: patient empowerment, patients’ association, empowerment, skills, codesign techniques, cancer
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Analýza vnějšího prostředí pro vybranou firmu
ONDOKOVÁ, Lucie
2012-01-01
The aim of my bachelor thesis was to appreciate the current situation and market position of the building company Milan Hodboď through analysis of external environment.For analyse of external environment I used STEP analyse and Porter´s model of five powers. STEP analyse detects effects from macroenvironment (social and cultural, technical and technological, economic, political and legislative). Porter´s model five forces studies microenvironment (new competition, customers, suppliers, substi...
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Andrea Giacomelli; Letizia Oreni; Marco Franzetti; Valentina Di Cristo; Barbara Vergani; Manuela Morosi; Elisa Colella; Massimo Galli; Stefano Rusconi
2014-01-01
Introduction: Since antiretroviral therapy must be taken lifelong, persistence and safety have become the goals to achieve. Protease inhibitors, in particular atazanavir (ATV) with or without ritonavir (r), represent a highly prescribed class in real life long-term treatment. Methods: We conducted a retrospective cohort study in HIV-1-positive patients who were followed at the Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan. Data regarding viral load, CD4 lymphocytes and the ...
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Mr. Eduard Zeman, Minister of Education, Youth and Sport, Czech Republic
Patrice Loïez
2001-01-01
Mr Eduard Zeman (third from left), Minister of Education, Youth and Sport, Czech Republic, visiting CERN's permanent exhibition, Microcosm, with (from left to right) Dr Rupert Leitner, ATLAS Tile Calorimetry Project Leader; Mr P. Cink, Ministry of Education, Youth and Sport; Dr Ivan Lehraus, Committee for Collaboration of the Czech Republic with CERN; and H.E. Mr Milan Hovorka, Ambassador, permanent representative of the Czech Republic to the United Nations in Geneva.
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Beam diagnostic elements at the Laboratorio Nazionale del Sud
International Nuclear Information System (INIS)
Calabretta, L.; Cuttone, G.; Raia, G.
1988-01-01
The choice of the main beam diagnostic elements at the LNS has to take into account the future installation of the Milan Superconducting Cyclotron and its matching to the MP tandem in Catania. A diagnostic box, consisting of a home-made beam profile monitor, a pair of slits and a Faraday cup, has been designed according to these particular requirements. The main features of these diagnostic elements and preliminary results are described. (orig.)
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Babuder, Maks; Gradnik, Timotej; Končan-Gradnik, Maja
2006-01-01
The paper presents different risk aspects of transformer insulation breakdown caused by ageing of transformer insulation. Evaluation of recent artificial ageing of paper-in-oil transformer insulation results explains the effect of winding temperature on the achievement of the targeted transformer lifetime. These results and findings of two studies made at the Milan Vidmar Electric Power Research Institute (EIMV) in 2004/2005 assessing the ageing and cooling system state of large power transfo...
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Degli Esposti, Luca; Favalli, Ennio Giulio; Sangiorgi, Diego; Di Turi, Roberta; Farina, Giuseppina; Gambera, Marco; Ravasio, Roberto
2016-01-01
Luca Degli Esposti,1 Ennio Giulio Favalli,2 Diego Sangiorgi,1 Roberta Di Turi,3 Giuseppina Farina,4 Marco Gambera,5 Roberto Ravasio,6 1CliCon S.r.l. – Health, Economics & Outcomes Research, Ravenna, 2Department of Rheumatology, Istituto Ortopedico Gaetano Pini, Milan, 3Local Pharmaceutical and Supplementary Assistance Unit, Roma Local Health Authority D, Rome, 4Internal Management Control Unit – Pharmaceutical Spending Control Sector, Caserta Local Health ...
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Sedda, Anna; Bottini, Gabriella
2014-01-01
Anna Sedda,1,2 Gabriella Bottini1,21Department of Behavioral and Brain Sciences, University of Pavia, Pavia, 2Cognitive Neuropsychology Laboratory, Niguarda Ca’ Granda Hospital, Milan, ItalyAbstract: This review summarizes the available studies of a rare condition in which individuals seek the amputation of a healthy limb or desire to be paraplegic. Since 1977, case reports and group studies have been produced, trying to understand the cause of this unusual desire....
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1989-10-30
Effectiveness [RUDE PR.4 VO 12 Jul] 4 Socialist Party Discusses Reactivation [SVOBODNE SLOVO 26 Sep] 5 Air Pollution Still Serious Problem...can get penicillin and painkillers only on the black market." None of the refugees wanted their names or where they came from published since all...changes himself. Regime’s Glasnost Criticized for Lack of Effectiveness 24000162 Prague RUDE PRA VO inCzechU Jul 89 p 3 [Article by Milan Geryk
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Failed back surgery syndrome: review and new hypotheses
Bordoni, Bruno; Marelli,Fabiola
2016-01-01
Bruno Bordoni,1,2 Fabiola Marelli2 1Department of Cardiology, Foundation Don Carlo Gnocchi, IRCCS, Institute of Hospitalization and Care, S Maria Nascente, Milan, 2School CRESO, Osteopathic Centre for Research and Studies, Falconara Marittima, Ancona, Italy Abstract: Failed back surgery syndrome (FBSS) is a term used to define an unsatisfactory outcome of a patient who underwent spinal surgery, irrespective of type or intervention area, with persistent pain in the lumbosacral region with or ...
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Regeneration Through Hidden Historical Landscape of Lecco. Urban Course Design Process
Colucci, Angela; Kolmogorova, Anna; Kraja, Benida; Ziyaee, Maryam
2017-01-01
The article focus on the role of Historical Urban Heritage in Urban Design through the presentation of the integrated learning path developed for Urban Design and Urban Design Studio classes of Lecco Campus of Politecnico of Milan (school of Architecture Urban Planning Construction Engineering, master degree in Building and Architectural Engineering - BAE and Architectural-Engineering– EDA). The first part of paper presents the general learning process characterizing Urban Design course a...
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Italian Foreign Policy: Trends for the Twenty-First Century
2003-06-01
without the love and support of my wife, Dr. Lucia Mariani. While my time at NPS marks only another episode in the unfailing support she has always... della Sinistra). In this transformation, however, the PDS lost support from the hard line Marxists that had supported the PCI. “The split between...Milan, FrancoAngeli, 1998), 95-113. 107 Lucio Caracciolo, Terra Incognita: Le radici geopolitiche della crisi italiana, (Rome, Gius. Laterza and
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Virtual Reality Adaptive Stimulation in Stress Resistance Training
2011-04-01
Kukolja, Branimir Dropuljić University of Zagreb Faculty of Electrical Engineering and Computing, Unska 3, 10000 Zagreb , Croatia Ivica Kostović...Miloš Judaš, Marko Radoš, Milan Radoš, Lana Vasung, Branka Bartolić Spajić University of Zagreb School of Medicine, Croatian Institute for Brain...Research, Šalata 12, 10000 Zagreb , Croatia Svjetlana Doričić, Dalibor Mesić Ministry of Defense, Republic of Croatia ABSTRACT Serious mental health
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Kvantitativní analýza léčiv v biologických materiálech separačními metodami
Maláková, Jana
2012-01-01
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: PharmDr. Jana Maláková Supervisor: Doc. PharmDr. Milan Nobilis, PhD., Associate Professor of Bioorganic Chemistry. Title of Doctoral Thesis: Quantitative measurement of drugs in biological samples using chromatography methods. The thesis deals with the application of instrumental analytical methods to the quantitative measurement of drugs and their metabolites...
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Directory of Open Access Journals (Sweden)
B. Rossaro
2015-08-01
Full Text Available The Journal of Entomological and Acarological Research (JEAR, formerly the Bollettino di Zoologia Agraria e di Bachicoltura of the Institute of Entomology of the University of Milan, was founded in 1928 by Remo Grandori (1928-1955. Prof. Grandori became the first Director of the journal, followed by his wife Luigia Grandori (1956-1957, Minos Martelli (1958-1985 and Luciano Süss (1986-2011. In 2012, the Editor, the Department of Agri-food Systems Protection (DiPSA - University of Milan, come to the decision to move from the paper version to the online open access version of JEAR, with the aim to reach all researchers in the field with a restyled editorial, and with Giuseppe Carlo Lozzia as Editor in Chief (2012-2014. Thanks to the contributions of prestigious scientists and young researchers from all over the world, the Journal published many papers, which were downloaded in numerous countries across the world. Recently, the new Editor, the Department of Food Environmental and Nutritional Sciences - University of Milan, named me as Editor-in-Chief and I happily accepted the invitation with the objective to give new energy to the JEAR through the publication of more and more research papers of recognized scientific quality. The Journal will maintain its actual structure with four subject areas steered by internationally recognized Section Editors, who are now supported by a new and larger Editorial Board. The JEAR publishes papers on systematics, geographical speciation and evolution, aquatic and terrestrial entomology, ecological system dynamics, phenology and modelling for integrated pest control, agricultural and stored product pests, urban veterinary and forensic entomology, plant insect interaction and ecosystems, biological control and agro-ecology, and all other subjects related to the four subject areas. I hope the journal will continue to receive the attention of the researchers, in particular our younger colleagues in whose hands is
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Conference: “Space and Research: Which future for the coming generation” | 18 September | Uni Mail
Stefania Pandolfi
2015-01-01
On Friday, 18 September, Luca Parmitano (Major in the Italian Air Force and European Space Agency astronaut), Guido Tonelli (CERN phycisist) and Amalia Ercoli Finzi (Emeritus Professor in the Aerospace department of the Polytechnic University of Milan and a Principal Investigator of the ESA Rosetta spacecraft) will present their visions of the future of research and space exploration. Free entrance. Limited number of seats - registration is essential, click here. For more information contact fc-italie@unige.ch.
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Regenerative liver surgeries: the alphabet soup of emerging techniques.
Parekh, Maansi; Kluger, Michael D; Griesemer, Adam; Bentley-Hibbert, Stuart
2016-01-01
New surgical procedures taking advantage of the regenerative abilities of the liver are being introduced as potential curative therapies to these patients either to provide auxiliary support while the native liver recovers or undergoes hypertrophy. For patients with hepatocellular carcinoma outside of the Milan criteria or bilobar colorectal metastases liver transplantation is not an option. Fulminant hepatic failure can be treated but requires life-long immunosuppression. These complex surgical procedures require high quality and directed imaging.
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L.O.T.O. - Landscape Opportunities For Territorial Organization
Directory of Open Access Journals (Sweden)
Anna Rossi
2015-11-01
Full Text Available The European Union promoted the transnational cooperation project L.O.T.O. (Landscape Opportunities for Territorial Organization by the program Interreg IIIB CADSES. The project gave up the illustration of some outputs in the seminar Landscape opportunities. Guidelines for the landscape management of the territorial transformations (Milan, 2005, October 6th-7th. This paper is a summary of introduction at the project. The attaches are the original reports of the end seminar.
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Il Grande Oriente d’Italia e l’educazione: l’azione delle logge nelle grandi città (1868-1925
Directory of Open Access Journals (Sweden)
Demetrio Xoccato
2017-01-01
Full Text Available The present paper focuses on the Italian Freemasonry’s engagement in the educational field. From 1868 to 1925, the lodges under the Grand Orient of Italy fostered and helped many educational establishments. The article considers the following three cities: Turin, Milan and Rome. These important urban centres were different but shared a large number of initiatives and were willing to experiment with new secular learning models (Boarding schools, institutes, leisure courses, evening classes and Popular Universities.
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Directory of Open Access Journals (Sweden)
Rohan Wickramasinghe
2007-12-01
Full Text Available The article was published in the Sri Lankan newspaper 'The Island' on the 30th November 2005 after the World Environmental Education Congress (WEEC held in Milan. Author hopes it could provide a base for a project for senior school children or more senior students to devise an Ecological Index and ‘If nothing else, it could help them in thinking out the issues involved!’ Author supposes that could be a form of environmental education.
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Agile working as a key for diversity: the Siemens office project
S. Cuomo; A. Mapelli
2014-01-01
Following directives from corporate headquarters in 2011, the Real Estate Division of Siemens Italia faced the challenge of implementing significant changes in work organisation, which arose from the need to consolidate all the Milan-based offices into a single location; a Green Building, characterised by a reduction of the available floor space, compared to the sum of the local offices. However, this reorganisation was perceived as stimulus to think of this change, not only in relation to sp...
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3cixty: Building comprehensive knowledge bases for city exploration
Troncy, Raphaël; Rizzo, Giuseppe; Jameson, Anthony; Corcho, Oscar; Plu, Julien; Palumbo, Enrico; Ballesteros Hermida, Juan Carlos; Spirescu, Adrian; Kuhn, Kai Dominik; Barbu, Catalin; Rossi, Matteo; Celino, Irene; Agarwal, Rachit; Scanu, Christian; Valla, Massimo
2017-01-01
International audience; Planning a visit to Expo Milano 2015 or simply touring in Milan are activities that require a certain amount of a priori knowledge of the city. In this paper, we present the process of building such comprehensive knowledge bases that contain descriptions of events and activities, places and sights, transportation facilities as well as social activities, collected from numerous static, near-and real-time local and global data providers, including hyper local sources suc...
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VALDALISO CASANOVA, TERESA
2016-01-01
[EN] Studio Azzurro is, probably, the main exponent in the field of research, experimentation and artistic hybridization with regard to the audio-visual language and the new technologies, inside the current Italian scene. Founded in Milan in 1982 by three artists, Paolo Rosa, Fabio Cirifino and Leonardo Sangiorgi, from the beginning they have opted for the collaborative team work, distancing themselves from the opinions of the critique and from the art market. Characterized by a militant past...
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Secondary school teachers and mental health competence: Italy–United Kingdom comparison
Monducci, Elena; Battaglia, Claudia; Forte, Alberto; Masillo, Alice; Telesforo, Ludovica; Carlotto, Alessandra; Piazzi, Gioia; Patanè, Martina; De Angelis, Giulia; Romano, Antonio; Fagioli, Francesca; Girardi, Paolo; Cocchi, Angelo; Meneghelli, Anna; Alpi, Andrea
2016-01-01
Aim: The aim of this study was to evaluate the differences between teachers' knowledge about early psychosis among three different Italian cities and a UK sample.\\ud \\ud \\ud Methods: The sample consisted of 556 secondary school teachers from three different cities in Italy (Milan, Rome and Lamezia Terme) and London (UK). The research was based on the Knowledge and Experience of Social Emotional Difficulties Among Young People Questionnaire. The Italian version of the questionnaire was used in...
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Personal exposure to airborne ultrafine particles in the urban area of Milan
International Nuclear Information System (INIS)
Cattaneo, A; Garramone, G; Taronna, M; Peruzzo, C; Cavallo, D M
2009-01-01
The relevance of health effects related to ultrafine particles (UFPs; aerodynamic diameter 5 particles/cm 3 . UFPs measures were divided on the basis of crossed environments or micro-environments, days of the week and day time (hours). The highest measured mean concentrations and data variability were observed during walking time and moving on motorized vehicles (bus and car), indicating that the highest exposure to UFPs can be reached near motorized traffic. The lowest exposures were observed in green areas and in office microenvironments. An appreciable difference between working and non-working days was observed. Concentration patterns and variation by days of the week and time periods appears related to time trends in traffic intensity.
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Personal exposure to airborne ultrafine particles in the urban area of Milan
Cattaneo, A.; Garramone, G.; Taronna, M.; Peruzzo, C.; Cavallo, D. M.
2009-02-01
The relevance of health effects related to ultrafine particles (UFPs; aerodynamic diameter car), indicating that the highest exposure to UFPs can be reached near motorized traffic. The lowest exposures were observed in green areas and in office microenvironments. An appreciable difference between working and non-working days was observed. Concentration patterns and variation by days of the week and time periods appears related to time trends in traffic intensity.
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Multifocal entrepreneurial practices : the case of Moroccan import/export businesses in Milan
Solano, G.
2016-01-01
In recent years, the topic of cross-border businesses developed by immigrants (transnational entrepreneurship) has emerged as one of the most interesting areas of research in studies on immigrants and their economic activities. From a theoretical standpoint, the paper proposes to use the concept of
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Milan Army Ammunition Plant. Remedial Investigation Report. Volume 4. Appendices M - T
1991-12-01
and it acts as an insulin antagonist in intermediary carbohydrate metabolism (NRC 1980). Ingestion of excess potassium results in hyperkalemia which...LOCALLY PRODUCED BEEF As discussed in Section 9, some beef and dairy cattle are raised in the MAAP area, although beef cattle are more prevalent (personal...in beef. It was assumed that four percent (Fries 1987) of a beef cow’s total dry matter intake would be soil. Not all of the chemical that a beef cow
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Marginal Uncertainties Making a Living and Working on the Outskirts of Milan
Directory of Open Access Journals (Sweden)
Giacomo Pozzi
2017-07-01
Full Text Available In this article we question the meanings and social practices related to living and working in the Social Housing neighbourhoods of Milan’s present-day suburbs. Through the reconstruction of several narratives, we shed light on how uncertainty characterises the professional everyday lives of those social actors who play a particularly significant role in Milan’s complex arena of social housing management (social workers; bailiffs; inspectors; “trouble-solvers”. Isolation, neglect and conflict are the main terms used by the social actors, both to describe the ongoing housing precarity of those who are at risk of losing their homes and to frame the current conditions of social housing. These represent crucial interpretative keys for developing a thick understanding of the housing crisis.
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Directory of Open Access Journals (Sweden)
Matteo Cescon
2010-01-01
Full Text Available Background. Factors affecting outcomes after orthotopic liver transplantation (OLT for hepatocellular carcinoma (HCC have been extensively studied, but some of them have only recently been discovered or reassessed. Methods. We analyzed classical and more recently emerging variables with a hypothetical impact on recurrence-free survival (RFS in a single-center series of 283 patients transplanted for HCC between 1997 and 2009. Results. Five-year patient survival and RFS were 75% and 86%, respectively. Thirty-four (12% patients had HCC recurrence. Elevated preoperative alpha-fetoprotein (AFP levels, preoperative treatments of HCC, unfulfilled Milan and up-to-seven criteria at final histology, poor tumor differentiation, and tumor microvascular invasion negatively affected RFS by univariate analysis. Milan and up-to-seven criteria applied preoperatively, and the use of m-TOR inhibitors did not reach statistical significance. Cox's proportional hazard model showed that only elevated AFP levels (Odds Ratio=2.88; 95% C.I.=1.43–5.80; =.003, preoperative tumor treatments (Odds Ratio=4.84; 95% C.I.=1.42–16.42; =.01, and microvascular invasion (Odds Ratio=4.82; 95% C.I.=1.87–12.41; =.001 were predictors of lower RFS. Conclusions. Biological aggressiveness and preoperative tumor treatment, rather than traditional and expanded dimensional criteria, conditioned the outcomes in patients transplanted for HCC.
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Frati, Elena R; Fasoli, Ester; Martinelli, Marianna; Colzani, Daniela; Bianchi, Silvia; Carnelli, Luciana; Amendola, Antonella; Olivani, Pierfranco; Tanzi, Elisabetta
2017-06-20
Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs) in undocumented migrant women in Milan, Italy. Women (ages 18-65) were enrolled at the NAGA Centre (2012-2013) and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV), Chlamydia trachomatis ( Ct ), Trichomonas vaginalis ( Tv ), Neisseria gonorrhoeae ( Ng )-DNA. Socio-demographic and sexual behavior information were collected. All HPV/ Ct + women were offered Pap tests and/or were prescribed antibiotic treatment. 537/757 women participated in the study (acceptability rate: 70.9%). Most of the women were from Latin America (45.6%) and Eastern Europe (30.7%); >60% of them had stable partners, did not use contraception and had had at least one pregnancy. The prevalence rates of HPV, Ct , Tv and Ng infections were 24.2%, 7.8%, 4.8% and 0%, respectively. In all, 43.2% of the positive women agreed to undergo a gynecological examination and accepted suitable treatment. This study shows an overall high prevalence of STIs in undocumented migrant women in Milan. The screening strategy based on counseling and urine testing contributed to the successfully high acceptability rate. More appropriate health services that adequately address all aspects of women's health are required.
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Zanzani, Sergio Aurelio; Gazzonis, Alessia Libera; Scarpa, Paola; Berrilli, Federica; Manfredi, Maria Teresa
2014-01-01
Intestinal parasites of dogs and cats are cosmopolitan pathogens with zoonotic potential for humans. Our investigation considered their diffusion in dogs and cats from northern Italy areas, specifically the metropolitan area of Milan and two micropolitan areas of neighboring provinces. It included the study of the level of awareness in pet owners of the zoonotic potential from these parasites. A total of 409 fresh fecal samples were collected from household dogs and cats for copromicroscopic analysis and detection of Giardia duodenalis coproantigens. The assemblages of Giardia were also identified. A questionnaire about intestinal parasites biology and zoonotic potential was submitted to 185 pet owners. The overall prevalence of intestinal parasites resulted higher in cats (47.37%-60.42%) and dogs (57.41%-43.02%) from micropolitan areas than that from the metropolis of Milan (dogs: P = 28.16%; cats: P = 32.58 %). The zoonotic parasites infecting pets under investigation were T. canis and T. cati, T. vulpis, Ancylostomatidae, and G. duodenalis assemblage A. Only 49.19% of pet owners showed to be aware of the risks for human health from canine and feline intestinal parasites. Parasitological results in pets and awareness determination in their owners clearly highlight how the role of veterinarians is important in indicating correct and widespread behaviors to reduce risks of infection for pets and humans in urban areas.
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Disease-modifying drugs in Alzheimer's disease
Directory of Open Access Journals (Sweden)
Ghezzi L
2013-12-01
Full Text Available Laura Ghezzi, Elio Scarpini, Daniela Galimberti Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy Abstract: Alzheimer's disease (AD is an age-dependent neurodegenerative disorder and the most common cause of dementia. The early stages of AD are characterized by short-term memory loss. Once the disease progresses, patients experience difficulties in sense of direction, oral communication, calculation, ability to learn, and cognitive thinking. The median duration of the disease is 10 years. The pathology is characterized by deposition of amyloid beta peptide (so-called senile plaques and tau protein in the form of neurofibrillary tangles. Currently, two classes of drugs are licensed by the European Medicines Agency for the treatment of AD, ie, acetylcholinesterase inhibitors for mild to moderate AD, and memantine, an N-methyl-D-aspartate receptor antagonist, for moderate and severe AD. Treatment with acetylcholinesterase inhibitors or memantine aims at slowing progression and controlling symptoms, whereas drugs under development are intended to modify the pathologic steps leading to AD. Herein, we review the clinical features, pharmacologic properties, and cost-effectiveness of the available acetylcholinesterase inhibitors and memantine, and focus on disease-modifying drugs aiming to interfere with the amyloid beta peptide, including vaccination, passive immunization, and tau deposition. Keywords: Alzheimer's disease, acetylcholinesterase inhibitors, memantine, disease-modifying drugs, diagnosis, treatment
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Directory of Open Access Journals (Sweden)
Di Pierro F
2015-09-01
Full Text Available Francesco Di Pierro,1 Daniele Di Pasquale,2 Maurizio Di Cicco2 1Velleja Research, Milan, Italy; 2ORL Department, Ospedale Maggiore Policlinico Ca’ Grande IRCCS, Milan, Italy Abstract: Secretory otitis media (SOM remains a common disease among children. Although its cause is not yet perfectly established, the pathology, often a sequel of acute otitis media (AOM, is mainly characterized by persistent fluid in the middle ear cavity. Twenty-two children with a diagnosis of SOM were treated daily for 90 days with an oral formulation containing the oral probiotic Streptococcus salivarius K12 (Bactoblis®. After treatment, the children were evaluated for AOM episodes and subjected to tone audiometry, tympanometry, endonasal endoscopy, otoscopy, and tonsillar examination. Subject compliance and probiotic tolerability and side effects have also been evaluated. Our results indicate a good safety profile, a substantial reduction of AOM episodes, and a positive outcome from the treatment for all of the clinical outcomes tested. We conclude that strain K12 may have a role in reducing the occurrence and/or severity of SOM in children. From our perspective, this study constitutes a starting point toward the organization of a more extensive placebo-controlled study aimed at critically appraising our preliminary observations. Keywords: BLIS K12, Bactoblis®, acute otitis media, exudative otitis media
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Zanzani, Sergio Aurelio; Gazzonis, Alessia Libera; Berrilli, Federica
2014-01-01
Intestinal parasites of dogs and cats are cosmopolitan pathogens with zoonotic potential for humans. Our investigation considered their diffusion in dogs and cats from northern Italy areas, specifically the metropolitan area of Milan and two micropolitan areas of neighboring provinces. It included the study of the level of awareness in pet owners of the zoonotic potential from these parasites. A total of 409 fresh fecal samples were collected from household dogs and cats for copromicroscopic analysis and detection of Giardia duodenalis coproantigens. The assemblages of Giardia were also identified. A questionnaire about intestinal parasites biology and zoonotic potential was submitted to 185 pet owners. The overall prevalence of intestinal parasites resulted higher in cats (47.37%−60.42%) and dogs (57.41%−43.02%) from micropolitan areas than that from the metropolis of Milan (dogs: P = 28.16%; cats: P = 32.58 %). The zoonotic parasites infecting pets under investigation were T. canis and T. cati, T. vulpis, Ancylostomatidae, and G. duodenalis assemblage A. Only 49.19% of pet owners showed to be aware of the risks for human health from canine and feline intestinal parasites. Parasitological results in pets and awareness determination in their owners clearly highlight how the role of veterinarians is important in indicating correct and widespread behaviors to reduce risks of infection for pets and humans in urban areas. PMID:24883320
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Grieco, Niccolò; Sesana, Giovanni; Corrada, Elena; Ieva, Francesca; Paganoni, Annamaria; Marzegalli, Maurizio
2012-09-01
Since 2001, the urban area of Milan has been operating a network among 23 cardiac care units, the 118 dispatch centre (national free number for medical emergencies), and the county government health agency called Group for Prehospital Cardiac Emergency. In order to monitor the network activity, time to treatment, and clinical outcome, a periodic survey, called MOMI(2), was repeated two or three times a year. Each survey lasted 30 days and was repeated in comparable periods. Data were stratified for hospital admission mode. We collected data concerning 708 consecutive ST-elevation myocardial infarction (STEMI) patients (male 72.6%; mean age 64.4 years). In these six surveys, we observed a high rate of primary percutaneous coronary intervention (73.2%) and a mortality rate of 6.3%. Using advanced statistical models, we identified age, Killip class, and the symptom onset-to-balloon time as most relevant prognostic factors. Nonparametric test showed that the modality of hospital admittance was the most critical determinant of door-to-balloon time. 12-lead ECG tele-transmission and activation of a fast track directly to the catheterization laboratory are easy action to reduce time to treatment. The experience of the Milan network for cardiac emergency shows how a network coordinating the community, rescue units, and hospitals in a complex urban area and making use of medical technology contributes to the health care of patients with STEMI.
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Otcovství v románech Milana Kundery
Labudová, Zuzana
2013-01-01
This thesis discusses the concept of fatherhood in the novels of Milan Kundera. The first part of the analysis focuses on initiation rituals leadings to the construction of the masculine identity and the future quality fatherhood; this thesis discusses unwanted fatherhood, the phenomenon of the missing father and the ethical aspects of the (non)fatherhood and the theme of fatherhood as a coming to terms with the world. I concentrate on the basic models od fatherhood in Kundera's novels, which...
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Future needs in radiation protection training for NPP workers of Slovenia
International Nuclear Information System (INIS)
Kozelj, M.; Bogovic, T.
1999-01-01
Short review of history of radiation protection training for NPP workers in Slovenia and legal requirements regarding this field are presented. Courses developed in co-operation between Milan Copic Nuclear Training Centre and Krsko Nuclear Power Plant are briefly described and their implementation presented. Using available data we have predicted probable number of courses and participants in forthcoming years. Some results from inquiry on courses for regularly exposed workers are presented, enabling us to modify courses according to participants' needs.(author)
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Lugares de la memoria, lugares de la ausencia en la poesía de Fabio Morábito
Fabiola Fernandez Adechedera
2015-01-01
This article proposes interpreting Fabio Morábito’s poetry taking into account its autobiographical features. The author´s biography places him in a geographical and linguistic displacement through Egypt, Italy and Mexico. Thereby, we analyze some poems that allow us to identify the presence of a personal memory referred to specific scenes of his childhood in Milan and his house moving to Mexico City. Such scenes settle the distinctive aspect of Morabito’s discursive identity, marked by uproo...
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Asian market plants for thermo-electric energy generation
International Nuclear Information System (INIS)
Antognazza, E.; Cozzi, G.
1998-01-01
This article synthesizes the analysis results carried out by IEFE (Bocconi University of Milan) on the evolution (1980-1997) and the present situation of industrial equipment orders for power generation in East and South Asia markets. At present these markets are the most important, on world scale, of the analyzed sector. Competitive positions changes have been analyzed, in every market and the whole Asian area, of the most important firms operating on international scale, as well as of the major local makers [it
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The Effects of Noise on Performance
1989-06-01
Performance" by C. S. Harris in W. D. Ward (Ed.) Proceedings of the International Congress on Noise as a Public Health Problem (EPA 550/9-73-008), 1973, U.S...141a duration tracking for primary task. Suggestion 35 at 1-9s Intervals Secondary task-response ot addivity for secondary 55 time task decrement. 95...In G. Rossi (Ed.) Pro eedings of the Fourth International Congress on Noise as a Public Health Problem, Vol- 2. Milan: Centro Ricerche e Studi
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The impact of moderate wine consumption on the risk of developing prostate cancer
Vartolomei,Mihai; Kimura,Shoji; Ferro,Matteo; Foerster,Beat; Abufaraj,Mohammad; Briganti,Alberto; Karakiewicz,Pierre; Shariat,Shahrokh
2018-01-01
Mihai Dorin Vartolomei,1,2,* Shoji Kimura,2,3,* Matteo Ferro,4 Beat Foerster,2,5 Mohammad Abufaraj,2,6 Alberto Briganti,7 Pierre I Karakiewicz,8 Shahrokh F Shariat2,9,10,11 1Department of Cell and Molecular Biology, University of Medicine and Pharmacy, Tirgu Mures, Romania; 2Department of Urology, Medical University of Vienna, Vienna, Austria; 3Department of Urology, Jikei University School of Medicine, Tokyo, Japan; 4Division of Urology, European Institute of Oncology, Milan, Italy;...
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1986-01-01
In June of this year »Migracijske teme« and the Centre for Migration and Nationalities Studies organized a round table on occasion of the Yugoslav publication of Giinter Wallraff's latest book Ganz unten (in Croatian translation: »Na samom dnu« (At the very bottom), Zagreb, Liber, 1986). Besides participants from the host institution (Milan Mesić, Melita Švob, Sreća Perunović), researchers and experts were invited from other Yugoslav centres — Peter Klinar (Faculty of Sociology, Political Sci...
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Tatarin, Milovan
2009-01-01
In the critical publication of Dundo Maroje which in 1930 was edited for the seventh book of the edition Stari pisci hrvatski (Old Croatian writers) by Milan Rešetar, »three Roman innkeepers« are named as dramatis personae. They appear on the stage three times: act one, scene one; act two, scene nine; act four, scene nine. The aim of this work is to establish how many inns and how many innkeepers appear in the comedy and are their lines mixed.
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Evolution of atmospheric radioactivity in Paris region. [In French
Energy Technology Data Exchange (ETDEWEB)
Abribat, M; Pouradier, J; Venet, A M
1953-01-01
Daily measurements of radioactivity have shown the passage of many atomic clouds, and particularly the series of explosions in the US and Russia, while those in the Pacific and Australia have been identified in Milan. For the Australian explosion in October 1953, there was no radioactive increase in the air in the Paris region, while for the Pacific explosion there were measurable fluctuations but very feeble. For the Russian explosions in August 1954, the fluctuations were much greater than for the Pacific ones.
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Anna Poli; Fulvio Benussi
2016-01-01
In Italy, little is being done to promote cinema studies and the ability to analyse films and/or multimedia works among high school students. Although Italian legislation provides guidelines on specific learning objectives, activities and content to be included in high school courses, film and media language is still not encouraged in schools. The pilot introduction of cinema at the C. Tenca High School in Milan had the aim of demonstrating the value of film as an educational and epistemologi...
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Plasmonic Bowtie Antenna Nanolaser
2014-05-06
OL.36.002447 Kang Ding, Zhicheng Liu, Leijun Yin, Hua Wang, Ruibin Liu, Martin T. Hill, Milan J. H. Marell, Peter J. van Veldhoven, Richard No?tzel, C...Eunice S. P. Leong, Barry Smalbrugge, Youcai Zhu, Minghua Sun, Peter J. van Veldhoven, Erik Jan Geluk, Fouad Karouta, Yok-Siang Oei, Richard ...lasers,” Nature Photonics, vol. 4, no. 6, pp. 395–399, Apr. 2010. [8] A. V. Krishnamoorthy, K. W. Goossen , W. Jan, X. Zheng, R. Ho, G. Li, R. Rozier, F
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Directory of Open Access Journals (Sweden)
Roggeri DP
2014-12-01
Full Text Available Daniela Paola Roggeri,1 Mario Cozzolino,2 Sandro Mazzaferro,3 Diego Brancaccio,4 Ernesto Paoletti,5 Alessandro Roggeri,1 Anna Maria Costanzo,6 Umberto di Luzio Paparatti,6 Vincenzo Festa,6 Piergiorgio Messa7 1ProCure Solutions, Nembro, Bergamo, 2Department of Health Sciences, University of Milan, Milan, 3Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, Sapienza University of Rome, Rome, 4Dialysis Unit NephroCare Simone Martini, Milan, 5Department of Nephrology, San Martino Hospital, Genoa, 6AbbVie Italy, Campoverde, Latina, 7Nephrology, Dialysis and Renal Transplant, Fondazione Ca Granda IRCCS Policlinico, Milan, Italy On behalf of the FARO Study Group Background: The aim of this analysis was to estimate biochemical parameters and the costs of treatment of secondary hyperparathyroidism (SHPT in a subpopulation of the FARO-2 study. Methods: The FARO-2 observational study aimed at evaluating the patterns of treatment for SHPT in naïve hemodialysis patients. Data related to pharmacological treatments and biochemical parameters (parathyroid hormone [PTH], calcium, phosphate were recorded at entry to hemodialysis (baseline and 6 months later (second survey. The analysis was performed from the Italian National Health Service perspective. Results: Two prominent treatment groups were identified, ie, one on oral calcitriol (n=105 and the other on intravenous paricalcitol (n=33; the intravenous calcitriol and intravenous paricalcitol + cinacalcet combination groups were not analyzed due to low patient numbers. At baseline, serum PTH levels were significantly higher in the intravenous paricalcitol group (P<0.0001. At the second survey, the intravenous paricalcitol group showed a higher percentage of patients at target for PTH than in the oral calcitriol group without changing the percentage of patients at target for phosphate. Moreover, between baseline and the second survey, intravenous paricalcitol significantly increased
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Directory of Open Access Journals (Sweden)
Colombo GL
2013-12-01
Full Text Available Giorgio L Colombo,1,2 Antonella Castagna,3 Sergio Di Matteo,2 Laura Galli,3 Giacomo Bruno,2 Andrea Poli,3 Stefania Salpietro,3 Alessia Carbone,3 Adriano Lazzarin3,41Department of Drug Sciences, School of Pharmacy, University of Pavia, Italy; 2Studi Analisi Valutazioni Economiche (S.A.V.E., Milan, 3Infectious Diseases Department, San Raffaele Hospital, Milan, 4Vita-Salute San Raffaele University, Milan, ItalyObjective: In the study reported here, single-tablet regimen (STR versus (vs multi-tablet regimen (MTR strategies were evaluated through a cost analysis in a large cohort of patients starting their first highly active antiretroviral therapy (HAART. Adult human immunodeficiency virus (HIV 1-naïve patients, followed at the San Raffaele Hospital, Milan, Italy, starting their first-line regimen from June 2008 to April 2012 were included in the analysis.Methods: The most frequently used first-line HAART regimens (>10% were grouped into two classes: 1 STR of tenofovir disoproxil fumarate (TDF + emtricitabine (FTC + efavirenz (EFV and 2 MTR including TDF + FTC + EFV, TDF + FTC + atazanavir/ritonavir (ATV/r, TDF + FTC + darunavir/ritonavir (DRV/r, and TDF + FTC + lopinavir/ritoavir (LPV/r. Data were analyzed from the point of view of the Lombardy Regional Health Service. HAART, hospitalizations, visits, medical examinations, and other concomitant non-HAART drug costs were evaluated and price variations included. Descriptive statistics were calculated for baseline demographic, clinical, and laboratory characteristics; associations between categorical variables and type of antiretroviral strategy (STR vs MTR were examined using chi-square or Fisher's exact tests. At multivariate analysis, the generalized linear model was used to identify the predictive factors of the overall costs of the first-line HAART regimens.Results: A total of 474 naïve patients (90% male, mean age 42.2 years, mean baseline HIV-RNA 4.50 log10 copies/mL, and cluster of
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1998-05-01
Sulfate Solution By Volume: In a 1 L volumetric flask, dissolve 20 g copper sulfate pentahydrate (CuS04 • 5H20) in about 800 mL water. Dilute to mark with...water. Invert to mix thoroughly. By Weight: To a 1 L container, add 20 g copper sulfate pentahydrate (CuS04 • 5H20) to 991 g water. Stir or shake...100 mL portion of 2% copper sulfate solution (reagent 5) to the cadmium prepared above. Swirl for about 5 minutes, then decant the liquid and
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Electron emission from laser irradiating target normal sheath acceleration (TNSA)
Czech Academy of Sciences Publication Activity Database
Torrisi, L.; Cutroneo, Mariapompea
2016-01-01
Roč. 171, 9-10 (2016), s. 754-765 ISSN 1042-0150. [12th Workshop on European Collaboration for Higher Education and Research in Nuclear Engineering and Radiological Protection. Bologna, Catania, Milan, 30.05.2016-01.06.2016] R&D Projects: GA ČR(CZ) GBP108/12/G108; GA MŠk LM2015056 Institutional support: RVO:61389005 Keywords : electron emission from plasma * TNSA * TOF * SiC * plastic scintillator * Thomson parabola spectrometer Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.443, year: 2016
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Cereda, Emanuele; Cilia, Roberto; Canesi, Margherita; Tesei, Silvana; Mariani, Claudio Bruno; Zecchinelli, Anna Lena; Pezzoli, Gianni
2017-01-01
Monoamine oxidase type B (MAO-B) inhibitors, such as selegiline and rasagiline, can be used as monotherapy or adjuvant therapy to levodopa in Parkinson?s disease (PD). Data on long-term efficacy of MAO-B inhibitors are limited with no head-to-head comparison available to date. The aim of this case?control retrospective study was to analyze data from patients with PD attending the Parkinson Institute (Milan, Italy) over a 6-year period (2009?2015) and compare the effects of selegiline and rasa...
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Assessing the Value of Systematic Cycling in a Polluted Urban Environment
Giorgio Guariso; Giulia Malvestiti
2017-01-01
The positive health effects of systematic cycling are weighted against the negative effects due to higher pollutant inhalation in the actual case of the city of Milan in northern Italy. The paper first evaluates the actual use of bikes in the city, and then considers why and how much such an active mobility style can be expanded. Two models are used to compare the outcome of cycling on the specific population sample with the equivalent path travelled by car. The first model computes the long ...
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Intersection how enterprise design bridges the gap between business, technology, and people
Guenther, Milan
2012-01-01
Many organizations struggle with the dynamics and the complexity of today''s social ecosystems that connect everyone and everything, everywhere and all the time. Facing challenges at the intersection of business models, technical developments, and human needs, modern enterprises must overcome the siloed thinking and isolated efforts of the past, and instead address their relationships to people holistically. In Intersection, Milan Guenther introduces a Strategic Design approach that aligns the overarching efforts of Branding, Enterprise Architecture, and Experience Design, and sets them on a
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[Electromyographic study of mastication muscles in patients with TMG osteoarthrosis].
Silin, A V; Satygo, E A; Semeleva, E I; Lila, A M
2014-01-01
The aim of this study was to determine the functional activity of cranio-mandibular system in patients with TMG osteoarthrosis. The study included 20 patients with TMG osteoarthrosis and 20 healthy subjects representing control group. The EMG examination was performed according to standard protocol developed in Milan University. The symmetry index values in the group with TMG osteoarthrosis were lower than in the control group (78.76±12.29%), while Torque values were higher (8.53±14.62%). EMG standardized indexes allowed differentiating TMG osteoarthrosis.
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The unveiling of life: Liturgy and the lure of kitsch
Directory of Open Access Journals (Sweden)
Johan Cilliers
2010-11-01
Full Text Available This article probes the classic definition of religious aesthetics as related to the notions of beauty, goodness and truth. The phenomenon of kitsch, understood as simulation (or inversion of beauty, goodness and truth, is taken cognisance of, especially in the light of contributions by Milan Kundera, Umberto Eco and Jean Baudrillard. The article briefly reflects on the liturgical consequences when kitsch manifests itself as simulated ‘beauty’, ‘goodness’ and ‘truth’ and concludes with some considerations regarding the characteristics of kitsch.
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Šimek, Milan
2009-01-01
Milan Šimek Pius II. a utrakvismus Pius II. and utraquism Based on sources work - out, the thesis aims the description and analysis of the attitude alternation of Enea Sylvio Piccolomini - Pius II to the utraquism. The conclusions stress the postulate that Pius II. did not change that attitude, but just did not succed in quelling the utraquist movement. In the sense of political background that finally led to fatal dissention among both leaders, king Jiří of Poděbrady and pope Pius II.
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DEFF Research Database (Denmark)
Frank, Søren
We live in an age of migration and more and more authors have migrant backgrounds. Migration and Literature offers a thorough and thought provoking examination of the thematic and formal role of migration in four contemporary and canonized novelists, Günter Grass, Milan Kundera, Salman Rushdie, a......, and Jan Kjærstad. This book examines how these novelists reflect, problematize, and "resolve" the problems set by the migratory world and analyzes how the novels employ discursive strategies which emphasize their migratory and homeless form....
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Life cycle design and design management strategies in fashion apparel manufacturing
Tutia, R.; Mendes, FD; Ventura, A.
2017-10-01
The generation of solid textile waste in the process of development and clothing production is an error that causes serious damages to the environment and must be minimized. The greatest volume of textile residues is generated by the department of cut, such as textiles parings and snips that are not used in the productive process. (MILAN et al, 2007). One way to conceive new products environmently conscious is turned to the adoption of a methodology based on Life Cycle Design (LCD) and Design Management.
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Polilinguismo nella scrittura murale urbana: Note sulla lingua spagnola
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ELena Landone
2016-01-01
Full Text Available Abstract – In this paper I focus on the polylinguistic and polycultural landscape of Milan on the theoretical basis of daily life studies, the sociolinguistics of globalization, and intercultural pragmatics. The relevance of this field is determined by the need for urban anthropology to semiotize the urban spaces as an interpretative bridge between the microsystem (the individual level and the macrosystem (the social level. More concretely, I investigate the presence of the Spanish language in the superdiversity of Milan and, methodologically, I collect ethnographically and interpret qualitatively a corpus of 700 daily life texts of various types of street writing. The results show the significant presence of Spanish in the urban landscape and a high level of hybridism which is, nevertheless, totally functional in communication. I also detect the emergence of linguistic, pragmatic and intercultural awareness in the writers. Finally, with some precautions, I confirm the scientific potential of the daily life documents to investigate complex urban dynamics.Resumen – El tema de este estudio es el panorama polilingüe y policultural de Milán y se plantea a partir de las bases teóricas de los everyday life studies, de la sociolingüistica de la globalización y de la pragmática intercultural. La relevancia del estudio descansa en la necesidad de la antropología urbana de elaborar una interpretación semiótica de los espacios urbanos, puesto que pueden constituir un puente interpretativo entre el microsistema (individuo y el macrosistema (sociedad. Concretamente, el objetivo es investigar el papel del idioma español en la supediversidad milanesa; la metodología es de etnografía urbana con la formación e interpretación cualitativa de un corpus fotográfico de setecientos textos cotidianos de escritura callejera (pintadas, avisos, grafiti, ecc.. Los datos relevan una presencia significativa del español en el landscape milanés, con un
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Frati, Elena R.; Fasoli, Ester; Martinelli, Marianna; Colzani, Daniela; Bianchi, Silvia; Carnelli, Luciana; Amendola, Antonella; Olivani, Pierfranco; Tanzi, Elisabetta
2017-01-01
Background: Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs) in undocumented migrant women in Milan, Italy. Methods: Women (ages 18–65) were enrolled at the NAGA Centre (2012–2013) and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV), Chlamydia trachomatis (Ct), Trichomonas vaginalis (Tv), Neisseria gonorrhoeae (Ng)-DNA. Socio-demographic and sexual behavior information were collected. All HPV/Ct+ women were offered Pap tests and/or were prescribed antibiotic treatment. Results: 537/757 women participated in the study (acceptability rate: 70.9%). Most of the women were from Latin America (45.6%) and Eastern Europe (30.7%); >60% of them had stable partners, did not use contraception and had had at least one pregnancy. The prevalence rates of HPV, Ct, Tv and Ng infections were 24.2%, 7.8%, 4.8% and 0%, respectively. In all, 43.2% of the positive women agreed to undergo a gynecological examination and accepted suitable treatment. Conclusions: This study shows an overall high prevalence of STIs in undocumented migrant women in Milan. The screening strategy based on counseling and urine testing contributed to the successfully high acceptability rate. More appropriate health services that adequately address all aspects of women’s health are required. PMID:28632191
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Löhe, Florian; Angele, Martin K; Rentsch, Markus; Graeb, Christian; Gerbes, Alexander; Löhrs, Udo; Beuers, Ulrich; Jauch, Karl-Walter
2007-01-01
Liver transplantation (OLT) for hepatocellular carcinoma (HCC) improves patient survival when tumor size and number are limited according to the Milan criteria. However, the impact of tumor size vs. the number of lesions for tumor recurrence after OLT is unclear. Microvascular invasion appears to be a significant risk factor for tumor recurrence. Therefore, it was the aim of this study to investigate tumor differentiation and microvascular invasion in relation to tumor number and size and their impact on survival after transplantation. In 97 adult HCC patients who underwent OLT between June 1985 and December 2005 the incidence of microvascular invasion, tumor differentiation, and the number and size of tumor lesions were analyzed retrospectively. Their impact on survival was studied by multivariate analysis. Microvascular invasion was the only independent negative predictor of survival after OLT for HCC (p = 0.025). Tumor size > 5 cm was predictive for microvascular invasion (p = 0.007). In contrast, tumor number did not affect the incidence of microvascular invasion or cumulative survival. The size of the largest HCC lesion, but not the number of tumors, determined microvascular invasion, a predictor of the outcome following OLT for HCC. Thus, the number of HCC lesions should not be applied to patient selection prior to OLT. These data support the extension of the Milan criteria for the selection of HCC patients for OLT with regard to tumor number, but not tumor size.
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Ozone in Lombardy: Years 1998-1999
Sesana, L.; Begnini, S.; Toscani, D.; Facchini, U.; Balasso, A.; Borelli, P.
2003-11-01
Photochemical pollutants, especially ozone, have reached very high levels in Lombardy in recent years, with peaks of up to 150 ppb in late spring and summer. Lombardy, lying on the Po Plain, supports a large number of cities and industries and these, along with heavy traffic, produce copious amounts of primary pollutants such as nitrogen oxides and numerous volatile organic compounds. Furthermore, the peculiar orography of this region fosters the stagnation of air masses on a basin-scale and the presence of diurnal breezes towards northern areas, along with the evolution of the Mixing Layer, spread the polluted air masses over a large territory. Numerous stations in Lombardy give the concentrations of ozone and of nitrogen oxides. In this paper, ozone measurements carried out at the plain area around Milan and at pre-alpine sites in the spring and summer 1998 and 1999 will be shown and discussed, focusing on the months of May and July. The study of temporal and spatial behaviour of ozone goes hand in hand with the analysis of the Boundary Layer's evolution. A number of radon stations were operating in Milan and in other sites in Lombardy. Measurements of atmospheric concentrations of radon yield an index of atmospheric stability, of the formation of thermal inversion, of convective turbulence, and of the movement of air masses, and hence they are very relevant to the understanding of the conditions of atmospheric pollutants.
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Osteopathic manipulative treatment is effective on pain control associated to spinal cord injury.
Arienti, C; Daccò, S; Piccolo, I; Redaelli, T
2011-04-01
This study was designed as an experimental study (trial). To verify the effects of the association between conventional pharmacological treatment and osteopathic manipulative treatment (OMT) for chronic pain management in spinal cord injury (SCI). This study was carried out at Spinal Unit, Ospedale Niguarda Ca' Granda, Milan, Italy. Istituto Superiore di Osteopatia, Milan, Italy. We enrolled 47 patients with SCI, 26 with pain of both nociceptive and neuropathic origin, and 21 with pure neuropathic pain. In all, 33 patients had a complete spinal cord lesion (ASIA level A) and 14 had incomplete lesion (ASIA level B, C and D). The patients were subdivided in a pharmacological group (Ph), a pharmacological osteopathic (PhO) group and a osteopathic (Os) group. The verbal numeric scale (VNS) was used at various time intervals to evaluate treatment outcomes. Ph patients reached a 24% improvement in their pain perception, assessed by the VNS scale after 3 weeks of treatment, whereas Os patients reached a 16% improvement in their pain perception for the same weeks. Both treatments per se failed to induce further improvements at later time points. In contrast, the combination of the two approaches yielded a significantly better pain relief both in patients with nociceptive or pure neuropathic pain in the PhO group. Our results suggest the OMT is a feasible approach in patients in whom available drugs cannot be used. Moreover, a benefit can be expected by the association of OMT in patients treated according to existing pharmacological protocols.
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Are pleiotropic effects of statins real?
Directory of Open Access Journals (Sweden)
Alberto Corsini
2007-11-01
Full Text Available Alberto Corsini, Nicola Ferri, Michele CortellaroDepartment of Pharmacological Sciences and Department of Clinical Sciences, “Luigi Sacco”, University of Milan, Milan, ItalyAbstract: The clinical benefits of statins are strongly related to their low density lipoproteincholesterol (LDL-C lowering properties. However, because mevalonic acid (MVA, the product of 3-hydroxy-3-methyl-3-glutaryl coenzyme A (HMG-CoA reductase reaction, is the precursor not only of cholesterol but also of nonsteroidal isoprenoid compounds, the inhibition of HMG-CoA reductase may result in pleiotropic effects, independent of their hypocholesterolemic properties. The discrimination between the pleiotropic from LDL-C lowering effects may potentially be more evident during the early phase of treatment since plasma MVA levels drop up to 70% within 1–2 hours while a reduction of LDL-C, detectable after 24 hours, became significant after 6–7 days. Therefore, the deprivation of circulating MVA-derived isoprenoids in the early phase of treatment could be the main mechanism responsible for the atheroprotective effect of statins. This early window of protection in the absence of LDL-C lowering suggests that the anti-inflammatory and the pleiotropic properties of statins may have clinical importance. Therefore, acute coronary syndromes could represent a clinical condition for addressing the early benefits of statins therapy, ie, within 24 h of the event, independent of LDL-C lowering.Keywords: anti-inflammatory effects of statins, mevalonate pathway, LDL lowering, acute coronary syndrome, prenylated proteins
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Directory of Open Access Journals (Sweden)
Elena R. Frati
2017-06-01
Full Text Available Background: Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs in undocumented migrant women in Milan, Italy. Methods: Women (ages 18–65 were enrolled at the NAGA Centre (2012–2013 and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV, Chlamydia trachomatis (Ct, Trichomonas vaginalis (Tv, Neisseria gonorrhoeae (Ng-DNA. Socio-demographic and sexual behavior information were collected. All HPV/Ct+ women were offered Pap tests and/or were prescribed antibiotic treatment. Results: 537/757 women participated in the study (acceptability rate: 70.9%. Most of the women were from Latin America (45.6% and Eastern Europe (30.7%; >60% of them had stable partners, did not use contraception and had had at least one pregnancy. The prevalence rates of HPV, Ct, Tv and Ng infections were 24.2%, 7.8%, 4.8% and 0%, respectively. In all, 43.2% of the positive women agreed to undergo a gynecological examination and accepted suitable treatment. Conclusions: This study shows an overall high prevalence of STIs in undocumented migrant women in Milan. The screening strategy based on counseling and urine testing contributed to the successfully high acceptability rate. More appropriate health services that adequately address all aspects of women’s health are required.
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Visualizing the data city social media as a source of knowledge for urban planning and management
Ciuccarelli, Paolo; Simeone, Luca
2014-01-01
This book investigates novel methods and technologies for the collection, analysis, and representation of real-time user-generated data at the urban scale in order to explore potential scenarios for more participatory design, planning, and management processes. For this purpose, the authors present a set of experiments conducted in collaboration with urban stakeholders at various levels (including citizens, city administrators, urban planners, local industries, and NGOs) in Milan and New York in 2012. It is examined whether geo-tagged and user-generated content can be of value in the creation
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Directory of Open Access Journals (Sweden)
Didier Aubert
2011-04-01
Full Text Available When I called him in early February, fine art-documentary-advertising photographer Larry Fink was just returning from men’s fashion week in Milan. The occasion for the trip was an exhibit of his work in collaboration with one of his regular clients, Woolrich Woolen Mills. Fink had shot the clothing company’s catalogue several times, but this was a different project. Documentary pictures of the logging community he had taken in the 1980s were used as background for a fashion show evoking “Man ...
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The idea of education and the contemporary world
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Petrović Aleksandar M.
2016-01-01
Full Text Available In a copious introduction to the very problem of education, the author of the study - The Philosophy of Education (Belgrade: Serbian State Publisher of Textbooks, Belgrade, 2016, Milan Uzelac, describes all the main articulated moments, which formed and directed the development of education on a social and historic level. The bases of his conceptions of education are phenomenological, elaborated in a methodological continuum. Through a thouroughful critical review of the current, in general very disappointing state of education in our country, Uzelac points to new, possible directions of development of education.
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Cappitelli, Francesca; Toniolo, Lucia; Sansonetti, Antonio; Gulotta, Davide; Ranalli, Giancarlo; Zanardini, Elisabetta; Sorlini, Claudia
2007-09-01
This study compares two cleaning methods, one involving an ammonium carbonate-EDTA mixture and the other involving the sulfate-reducing bacterium Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, for the removal of black crust (containing gypsum) on marble of the Milan Cathedral (Italy). In contrast to the chemical cleaning method, the biological procedure resulted in more homogeneous removal of the surface deposits and preserved the patina noble under the black crust. Whereas both of the treatments converted gypsum to calcite, allowing consolidation, the chemical treatment also formed undesirable sodium sulfate.
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Cappitelli, Francesca; Toniolo, Lucia; Sansonetti, Antonio; Gulotta, Davide; Ranalli, Giancarlo; Zanardini, Elisabetta; Sorlini, Claudia
2007-01-01
This study compares two cleaning methods, one involving an ammonium carbonate-EDTA mixture and the other involving the sulfate-reducing bacterium Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, for the removal of black crust (containing gypsum) on marble of the Milan Cathedral (Italy). In contrast to the chemical cleaning method, the biological procedure resulted in more homogeneous removal of the surface deposits and preserved the patina noble under the black crust. Whereas both of the treatments converted gypsum to calcite, allowing consolidation, the chemical treatment also formed undesirable sodium sulfate. PMID:17601804
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Simultaneous PIXE and PIGE analyses of aerosol samples collected in urban areas
International Nuclear Information System (INIS)
Boni, C.; Caruso, E.; Cereda, E.; Marcazzan, G.M.; Redaelli, P.; Bacci, P.
1988-01-01
The paper concerns the simultaneous PIXE (Particle Induced X-ray Emission) and PIGE (Proton Induced Gamma-ray Emission) analyses of aerosol samples collected in urban areas. The results show that PIGE can detect Li, F, Na, Al, and Si in fly ashes and F, Na, Al and Si in atmospheric aerosol. The PIXE-PIGE technique has also been applied to 80 samples of atmospheric particular matter collected above Milan during the winter and summer months of 1986/7, and the average values of concentrations and enrichment factors are given for the detected elements. (U.K.)
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Journal of Air Transportation, Volume 10, No. 2
Bowen, Brent (Editor); Unal, Mehmet (Editor); Gudmundsson, Sveinn Vidar (Editor); Kabashkin, Igor (Editor)
2005-01-01
Topics discussed include: Mitigation Alternatives for Carbon Dioxide Emissions by the Air Transport Industry in Brazil; Air Transport Regulation Under Transformation: The Case of Switzerland; An Estimation of Aircraft Emissions at Turkish Airports; Guide to the Implementation of Iso 14401 at Airports; The Impact of Constrained Future Scenarios on Aviation and Emissions; The Immediate Financial Impact of Transportation Deregulation on the Stockholders of the Airline Industry; Aviation Related Airport Marketing in an Overlapping Metropolitan Catchment Area: The Case of Milan's Three Airports; and Airport Pricing Systems and Airport Deregulation Effects on Welfare.
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Conference Scene: novelties in immunotherapy.
Mitsias, Dimitris I; Kalogiros, Lampros A; Papadopoulos, Nikolaos G
2013-10-01
The only method aiming to permanently cure allergic disorders is allergen immunotherapy. Over the last 20 years there has been great progress in understanding the mechanisms that govern allergen immunotherapy in order to meet three basic prerequisites: safety, effectiveness and compliance. In the present summary report from the European Academy of Allergology and Clinical Immunology-World Allergy Organization Congress held last June in Milan, we review key points concerning the main axes as diagnosis, novel modalities, routes and protocols, as well as two important immunotherapy fields: food and insect venom allergy.
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International Nuclear Information System (INIS)
Petriccione, M.; Raffone, E.; Rega, P.
2004-01-01
The harvest and post-harvest of Annurca apples involves a high utilization of manpower and high production costs. The low yield and the need to also compete on the market, in terms of price, specially in the Spring period, with the fresh apples imported by foreign Countries, has induced the ISF of Caserta, in collaboration with the Istituto per la Valorizzazione dei Prodotti Agricoli of Milan, to promote studies to decrease the costs of production, to improve the quality, to eliminate the necessity of redness or to artificially induce it [it
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Directory of Open Access Journals (Sweden)
Buggio L
2017-05-01
Full Text Available Laura Buggio,1,2 Giussy Barbara,3 Federica Facchin,4 Maria Pina Frattaruolo,1,2 Giorgio Aimi,2 Nicola Berlanda2 1Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 2Departmental Operating Unit of Surgical Gynecology and Endometriosis, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, 3Department of Obstetrics and Gynecology and Service for Sexual and Domestic Violence (SVSeD, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, 4Faculty of Psychology, Catholic University of Milan, Milan, Italy Abstract: Endometriosis has a multifactorial etiology. The onset and progression of the disease are believed to be related to different pathogenic mechanisms. Among them, the environment and lifestyle may play significant roles. Diet, dietary supplements, physical exercise, osteopathy, massage, acupuncture, transcutaneous electrical nerve stimulation, and Chinese herbal medicine may represent a complementary and feasible approach in the treatment of symptoms related to the disease. In this narrative review, we aimed to examine the most updated evidence on these alternative approaches implicated in the self-management of the disease. In addition, several studies have demonstrated that endometriosis may negatively impact mental health and quality of life, suggesting that affected women may have an increased risk of developing psychological suffering as well as sexual problems due to the presence of pain. In light of these findings, we discuss the importance of integrating psychological interventions (including psychotherapy and sexual therapy in endometriosis treatment. Keywords: sexual therapy, diet, physical activity, alternative medicine, psychotherapy
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International Nuclear Information System (INIS)
Bargellini, Irene; Sacco, Rodolfo; Bozzi, Elena; Bertini, Marco; Ginanni, Barbara; Romano, Antonio; Cicorelli, Antonio; Tumino, Emanuele; Federici, Graziana; Cioni, Roberto; Metrangolo, Salvatore; Bertoni, Michele; Bresci, Giampaolo; Parisi, Giuseppe; Altomare, Emanuele; Capria, Alfonso; Bartolozzi, Carlo
2012-01-01
Aim: To assess clinical outcome of transarterial chemoembolization (TACE) in a series of patients with early-stage hepatocellular carcinoma (HCC), within Milan criteria, but clinically unfit for liver transplantation (OLT). Methods: From January 2006 to May 2009, 67 patients (43 males, mean age 70 ± 7.6 years) with very early or early-stage unresectable HCC, within Milan selection criteria but clinically unfit for OLT, underwent TACE. The primary endpoint of the study was overall survival. Secondary endpoints were: safety, liver toxicity, 1-month tumour response according to the amended RECIST criteria, time to local and distant intrahepatic tumour recurrence and time to radiological progression. Results: Two major periprocedural complications occurred (3%), consisting of liver failure. Periprocedural mortality rate was 1.5% (1 patient). A significant increase in ALT and bilirubin levels 24 h after treatment was reported, with progressive decrease at discharge. At 1-month follow-up, complete and partial tumour response rates were 67.2% and 29.8%, respectively, with two cases of progressive disease. Mean follow-up was 37.3 ± 15 months. The 1-, 2-, and 3-year overall survival rates were 90.9%, 86.1%, and 80.5%, respectively. Median expected time to local tumour recurrence and intrahepatic tumour recurrence were 7.9 and 13.8 months, respectively. Radiological disease progression was observed in 12 patients (17.9%) with a mean expected time of 26.5 months. Conclusion: In patients with early-stage HCC, clinically excluded from OLT and unfit for surgery or percutaneous ablation, TACE is a safe and effective option, with favourable long-term survival.
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Phytoremediation of explosives in groundwater using innovative wetlands-based treatment technologies
Energy Technology Data Exchange (ETDEWEB)
Sikora, F.J.; Behrends, L.L.; Coonrod, H.S.; Phillips, W.D. [Tennessee Valley Authority, Muscle Shoals, AL (United States). Environmental Research Center; Bader, D.F. [Army Environmental Center, Aberdeen Proving Ground, MD (United States)
1997-12-31
Many army ammunition plants across the country have problems with groundwater contaminated with explosives. A field demonstration was initiated at the Milan Army Ammunition Plant near Milan, Tennessee early in 1996 to demonstrate the feasibility of treating contaminated groundwater with constructed wetlands. Two different systems were designed and installed. A lagoon system consisted of two cells in series with each cell having dimensions of 24 x 9.4 x 0.6 m (L x W x H). A gravel-bed system consisted of three gravel-beds operated in series with a primary anaerobic cell having dimensions of 32 x 11 x 1.4 m (L x W x H), followed by a pair of secondary cells each with dimensions of 5.5 x 11 x 1.4 m (L x W x H). The primary cell is maintained anaerobic by adding powdered milk to the water every two weeks. The secondary cells are maintained aerobic via reciprocation, whereby water is pumped back and forth from one cell to another to cause a recurrent fill and drain action. The lagoons were planted with sago pond weed, water stargrass, elodea, and parrot feather. The gravel-bed wetlands were planted with canary grass, wool grass, sweet flag, and parrot feather. Water began flowing to each of the wetland treatment systems at 19 L min{sup {minus}1} starting in June 1996. The design hydraulic retention time through each treatment system was approximately 10 days. Influent and effluent water samples were collected every 2 weeks. Intensive sampling of water interior to the wetlands occurred every 2 months.
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Na, Gun Hyung; Hong, Tae Ho; You, Young Kyoung; Kim, Dong Goo
2016-07-07
To evaluated patterns and outcomes of hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT). From 2001 to 2014, 293 patients underwent LDLT for HCC at our transplant center. We retrospectively reviewed 54 (18.4%) patients with HCC recurrence after LDLT. We evaluated patterns and outcomes of HCC recurrence after LDLT, with particular attention to the Milan criteria at transplantation, treatments for HCC-recurrent patients, and factors related to survival after HCC recurrence. Furthermore, we evaluated the efficacy of combination treatment of sorafenib and an mTOR inhibitor. The 1-, 2-, and 3-year overall survival rates after HCC recurrence were 41.1%, 20.5%, and 15.4%, respectively. The median time interval between LDLT and HCC recurrence was 6.5 mo. Although recurrence rates according to the Milan criteria at LDLT were significantly different, HCC recurrence patterns and survival rates after HCC recurrence were not significantly different between the two groups. Time to recurrence < 12 mo (P = 0.048), multiple recurrences at HCC recurrence (P = 0.038), and palliative treatment for recurrent tumors (P = 0.003) were significant independent prognostic factors for poor survival after HCC recurrence in a multivariate analysis. The combination treatment of sorafenib and sirolimus showed survival benefits in the palliative treatment group (P = 0.005). Curative treatment for recurrent HCC after LDLT is the most important factor in survival rates after HCC recurrence and combination treatments of sorafenib and an mTOR inhibitor could have survival benefits in patients with HCC recurrence after LT in the palliative treatment group.
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The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
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Paolo Gelosa
2007-11-01
Full Text Available Paolo Gelosa1, Mauro Cimino2, Alice Pignieri1, Elena Tremoli1,3, Uliano Guerrini1, Luigi Sironi11Department of Pharmacological Sciences, University of Milan, Italy; 2Institute of Pharmacological Sciences, Carlo Bo University of Urbino, Italy; 3Monzino Cardiologic Center IRCCS, Milan, ItalyAbstract: Statin-induced inhibition of HMG-CoA reductase reduces cholesterol production and prevents the formation of many non-steroidal isoprenoid compounds, such as farnesylpyrophosphate and geranylgeranylpyrophosphate, that act as lipid attachments for the post-translational modification of various proteins, including the G-proteins and transcription factors involved in a number of cell processes. However, the blockade of isoprenylation elicited by statin treatment also has biological effects on cell function that go beyond the decrease in cholesterol synthesis: these are the so-called “pleiotropic” effects that mainly relate to vascular function. Endothelial dysfunction is an independent predictor of cardiovascular events that correlates with inflammation markers/mediators and robust predictors of cardiovascular diseases such as increased high-sensitivity C-reactive protein levels. The results of in vivo and in vitro studies indicate that the statins have beneficial effects unrelated to cholesterol lowering, such as improving endothelial function, increasing myocardial perfusion, and enhancing the availability of nitric oxide. This review describes the pleiotropic effects of statins that may be involved in modulating/preventing endothelial dysfunction and inflammatory processes, as well as the cellular and molecular mechanisms through which they improve endothelial function.Keywords: statins; inflammation; endothelial dysfunction; nitric oxide; HMG-CoA reductase
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Performance of the NASA Beacon Receiver for the Alphasat Aldo Paraboni TDP5 Propagation Experiment
Nessel, James; Morse, Jacquelynne; Zemba, Michael; Riva, Carlo; Luini, Lorenzo
2015-01-01
NASA Glenn Research Center (GRC) and the Politecnico di Milano (POLIMI) have initiated a joint propagation campaign within the framework of the Alphasat propagation experiment to characterize rain attenuation, scintillation, and gaseous absorption effects of the atmosphere in the 40 gigahertz band. NASA GRC has developed and installed a K/Q-band (20/40 gigahertz) beacon receiver at the POLIMI campus in Milan, Italy, which receives the 20/40 gigahertz signals broadcast from the Alphasat Aldo Paraboni Technology Demonstration Payload (TDP) no. 5 beacon payload. The primary goal of these measurements is to develop a physical model to improve predictions of communications systems performance within the Q-band. Herein, we describe the design and preliminary performance of the NASA propagation terminal, which has been installed and operating in Milan since June 2014. The receiver is based upon a validated Fast Fourier Transform (FFT) I/Q digital design approach utilized in other operational NASA propagation terminals, but has been modified to employ power measurement via a frequency estimation technique and to coherently track and measure the amplitude of the 20/40 gigahertz beacon signals. The system consists of a 1.2-meter K-band and a 0.6-meter Q-band Cassegrain reflector employing synchronous open-loop tracking to track the inclined orbit of the Alphasat satellite. An 8 hertz sampling rate is implemented to characterize scintillation effects, with a 1-hertz measurement bandwidth dynamic range of 45 decibels. A weather station with an optical disdrometer is also installed to characterize rain drop size distribution for correlation with physical based models.
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Nessel, James; Morse, Jacquelynne; Zemba, Michael; Riva, Carlo; Luini, Lorenzo
2014-01-01
NASA Glenn Research Center (GRC) and the Politecnico di Milano (POLIMI) have initiated a joint propagation campaign within the framework of the Alphasat propagation experiment to characterize rain attenuation, scintillation, and gaseous absorption effects of the atmosphere in the 40 GHz band. NASA GRC has developed and installed a K/Q-band (20/40 GHz) beacon receiver at the POLIMI campus in Milan, Italy, which receives the 20/40 GHz signals broadcast from the Alphasat Aldo Paraboni TDP#5 beacon payload. The primary goal of these measurements is to develop a physical model to improve predictions of communications systems performance within the Q-band. Herein, we describe the design and preliminary performance of the NASA propagation terminal, which has been installed and operating in Milan since May 2014. The receiver is based upon a validated Fast Fourier Transform (FFT) I/Q digital design approach utilized in other operational NASA propagation terminals, but has been modified to employ power measurement via a frequency estimation technique and to coherently track and measure the amplitude of the 20/40 GHz beacon signals. The system consists of a 1.2-m K-band and a 0.6-m Qband Cassegrain reflector employing synchronous open-loop tracking to track the inclined orbit of the Alphasat satellite. An 8 Hz sampling rate is implemented to characterize scintillation effects, with a 1-Hz measurement bandwidth dynamic range of 45 dB. A weather station with an optical disdrometer is also installed to characterize rain drop size distribution for correlation with physical based models.
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Italian neuropsychology in the second half of the twentieth century.
Vallar, Giuseppe; Boller, François; Grossi, Dario; Gainotti, Guido
2015-03-01
Since the early 1960s, human neuropsychology, the study of brain-behavior interrelations, mainly based on the analysis of their pathological variations, brought about by brain damage, has had a remarkable systematical development in Italy. All this started in Milan, with the neurologist Ennio de Renzi, and his collaborators (Luigi Vignolo, then Anna Basso, Pietro Faglioni, Hans Spinnler, François Boller, and, more autonomously, Edoardo Bisiach), in the Clinic of Nervous and Mental Diseases. Scientists of the "Milan group" investigated several neuropsychological deficits caused by focal hemispheric lesions in large series of left- and right-brain-damaged patients, and control participants, comparable for cultural and demographic variables. Standardized tests and advanced statistical methods were used, which also applied to the diagnosis and rehabilitation of aphasia. Subsequently, neuropsychology developed in Italy extensively, reaching high international reputation. Leading neuropsychologists have been the neurologists Guido Gainotti (Rome), and Franco Denes (Padua), the physicians and psychologists Luigi Pizzamiglio (Rome), and Carlo Umiltà (Parma, with fruitful interactions with the neurophysiologists Giovanni Berlucchi, Giacomo Rizzolatti, and Carlo Marzi, from the school of Giuseppe Moruzzi in Pisa) A second scientific generation of neuropsychologists has then developed in the 1970s, trained by the abovementioned scientists, further boosting and spreading high-level basic and applied research (diagnosis and rehabilitation of neuropsychological deficits of patients with brain damage or dysfunction throughout the life span, from childhood to the elderly). Available techniques include structural and functional imaging (CT, PET, SPET, MRI and fMRI Scans, DTI), electrophysiological recording (EEG, ERPs), non-invasive brain stimulation (TMS, tES), and their combined use.
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3D Visualization of Cultural Heritage Artefacts with Virtual Reality devices
Gonizzi Barsanti, S.; Caruso, G.; Micoli, L. L.; Covarrubias Rodriguez, M.; Guidi, G.
2015-08-01
Although 3D models are useful to preserve the information about historical artefacts, the potential of these digital contents are not fully accomplished until they are not used to interactively communicate their significance to non-specialists. Starting from this consideration, a new way to provide museum visitors with more information was investigated. The research is aimed at valorising and making more accessible the Egyptian funeral objects exhibited in the Sforza Castle in Milan. The results of the research will be used for the renewal of the current exhibition, at the Archaeological Museum in Milan, by making it more attractive. A 3D virtual interactive scenario regarding the "path of the dead", an important ritual in ancient Egypt, was realized to augment the experience and the comprehension of the public through interactivity. Four important artefacts were considered for this scope: two ushabty, a wooden sarcophagus and a heart scarab. The scenario was realized by integrating low-cost Virtual Reality technologies, as the Oculus Rift DK2 and the Leap Motion controller, and implementing a specific software by using Unity. The 3D models were implemented by adding responsive points of interest in relation to important symbols or features of the artefact. This allows highlighting single parts of the artefact in order to better identify the hieroglyphs and provide their translation. The paper describes the process for optimizing the 3D models, the implementation of the interactive scenario and the results of some test that have been carried out in the lab.
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3D Visualization of Cultural Heritage Artefacts with Virtual Reality devices
Directory of Open Access Journals (Sweden)
S. Gonizzi Barsanti
2015-08-01
Full Text Available Although 3D models are useful to preserve the information about historical artefacts, the potential of these digital contents are not fully accomplished until they are not used to interactively communicate their significance to non-specialists. Starting from this consideration, a new way to provide museum visitors with more information was investigated. The research is aimed at valorising and making more accessible the Egyptian funeral objects exhibited in the Sforza Castle in Milan. The results of the research will be used for the renewal of the current exhibition, at the Archaeological Museum in Milan, by making it more attractive. A 3D virtual interactive scenario regarding the “path of the dead”, an important ritual in ancient Egypt, was realized to augment the experience and the comprehension of the public through interactivity. Four important artefacts were considered for this scope: two ushabty, a wooden sarcophagus and a heart scarab. The scenario was realized by integrating low-cost Virtual Reality technologies, as the Oculus Rift DK2 and the Leap Motion controller, and implementing a specific software by using Unity. The 3D models were implemented by adding responsive points of interest in relation to important symbols or features of the artefact. This allows highlighting single parts of the artefact in order to better identify the hieroglyphs and provide their translation. The paper describes the process for optimizing the 3D models, the implementation of the interactive scenario and the results of some test that have been carried out in the lab.
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Composição dramática e maiêutica no Teeteto de Platão
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Dennys Garcia Xavier
2007-06-01
Full Text Available My aim in this article is, through a concise analysis of the “socratic” midwifery digression, try to demonstrate the measure in which the Theaetetus characters choice establish the nature of the debate developed in the dialoghe. Emphasizing the Tübigen-Milan ermeneutical criterion, we also try to sketch a biographical profile of those characters – in a complete harmony with Plato´s written theory – to a correct adjustment of perspective on reading the dialoghe and bring into focus some of the mathematical arguments extracted from the VII book of the Republic, essencial to the Theaetetus philosophical drama.
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Cuenca Almenar, Salvador
2012-01-01
Se analiza la relación entre un fragmento de la sexta parte de La insoportable levedad del ser de Milan Kundera y los dos textos que le sirven de fuente: el Peri physeon de Escoto Eriúgena y el De civitate Dei de Agustín de Hipona. Los tres fragmentos analizados en este artículo mantienen una relación de copresencia llamada “alusión” por Genette. Se defiende que el paso de Kundera no es plenamente comprensible sin la intelección de sus fuentes. El problema conceptual desarrollado por los tres...
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THE SOUTH PAYS FOR THE NORTH: FINANCING THE THIRTY YEARS’ WAR FROM NAPLES, 1622-1644
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Antonio Calabria
2002-01-01
Full Text Available This paper examines the severe fiscal offensive which the Spanish Monarchy unleashed in the Kingdom of Naples during the Thirty Years’ War (1618-1648. Though the war was fought far from its borders, Naples was burdened with a whole range of new fiscal measures designed to aid the wareffort in Northern Europe and to protect the state of Milan from the contingencies of war. This paper provides a quantitative analysis of that burden. It uses archival fiscal documents to examine the various expedients Spain used to finance its designs and to plot their incidence from 1622 to1644.
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Scenes of shame, social Roles, and the play with masks
DEFF Research Database (Denmark)
Welz, Claudia
2014-01-01
This article explores various scenes of shame, raising the questions of what shame discloses about the self and how this self-disclosure takes place. Thereby, the common idea that shame discloses the self’s debasement will be challenged. The dramatic dialectics of showing and hiding display a much...... reflected, the self’s active reflections on its shame are to be taken into account. As examples from Milan Kundera, Shakespeare’s King Lear, a line from Kingsley Amis, a speech by Vaclav Havel and Adam Smith’s Theory of Moral Sentiments indicate, self-(re)presentation in the public and the private sphere...
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Directory of Open Access Journals (Sweden)
Mildeová Stanislava
2008-10-01
Full Text Available Title of the monograph: Systems Approach to Knowledge Modelling. Authors: dr. Ludmila Dömeová; dr. Milan Houška; dr. Martina Houšková Beránková. Cover designer: Olga Čermáková. Interior designer: Roman Kvasnička. Publisher: Graphical Studio Olga Čermáková, Czech Republic. Place: Hradec Králové, Czech Republic. Year of publication: 2008. Number of pages: 282. Recommended price of the book: 39.90 EUR. First edition. Reviewer : dr. Stanislava Mildeová; Department of Systems Analysis, Faculty of Informatics and Statistics, University of Economics, Prague.
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Mecanismos discursivos de promoción de eventos en la Web: los titulares de las Expos
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María José Rodrigo Mora
2012-02-01
Full Text Available This paper is in line with a national research project (PRIN about the Language of Tourism in Spanish and Italian: Lexical, Pragmatic and Intercultural Aspects. Our aim is to contribute to the study of digital tourist texts adopting a methodological perspective based on the most recent studies about the rhetoric of advertising, web advertising and institutional communication. We carry out a contrastive analysis of the headlines introducing news and press releases published on line within five promotional and touristic websites, those of the expositions of Sevilla (1992, Zaragoza (2008, Shanghai (2010, Italian pavilion, Shanghai (2010, Spanish pavilion, and Milan (2015.
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Public opinion about nuclear energy. Year 2007 poll
International Nuclear Information System (INIS)
Istenic, R.; Jencic, I.
2007-01-01
Nuclear Training Centre Milan Copic (Izobrazevalni center za jedrsko tehnologijo - ICJT) at Jozef Stefan Institute in Ljubljana incorporates the Information Centre for general public. Most of the visitors are youngsters and almost one half of every generation of schoolchildren in Slovenia is informed on nuclear energy by live lectures, exhibition, publications and laboratory demonstrations. About 1000 visitors are polled every year since 1993 to measure the opinion about nuclear power and get a feed-back for our activities. Continued operation of NPP Krsko is supported by 69% of youngsters (negative trend from the last year's 76%), while opposition remains low. (author)
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Gimnasio Sebastiani. Holy trinity high school - Trinidad, Colorado
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C. Toll, Henry
1959-05-01
Full Text Available Para completar las instalaciones y facilidades de que se ha dotado el Instituto Católico de Segunda Enseñanza de Trinidad, Colorado (Estados Unidos, se proyectó un gimnasio cubierto que podría ser utilizado como campo de deportes para baloncesto, representaciones, audiciones y actos públicos. El proyecto fue redactado por Toll & Milan, arquitectos, entidad disuelta actualmente y de la que el autor formaba parte como proyectista. En la formación de este proyecto se utilizaron las recomendaciones de un buen número de gabinetes de estudio y consulta.
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Building trust with the schoolchildren in the nuclear training centre
International Nuclear Information System (INIS)
Stritar, Andrej; Istenie, Radko
1995-01-01
Although Krsko Nuclear Power Plant has been in operation for more than ten years, comparatively little has been done in the field of systematic education and public information. Deficiencies in this field are causing serious misunderstandings about the role of nuclear power and is having a negative impact on its public acceptance. At The Nuclear Training Centre Milan Copic (NTC) in Ljubljana we have prepared a presentation on nuclear energy encompassing a short description of a PWR nuclear power plant, importance of nuclear power in the world and in Slovenia, basic ideas of nuclear safety and radioactive waste disposal
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The case of Via Barzoni 11. ‘Tailored’ participatory planning of social housing
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Paolo Carli
2012-10-01
Full Text Available The social housing complex located in Via Barzoni 11, Milan, was singled out in 2009 for a demolition and rebuilding plan, featuring a volume growth, strongly opposed by the inhabitants. Between April and June 2012 ALER1 Milano, with the involvement of Comune di Milano – Direzione Casa2, commissioned a working group supervised by Anna Delera, Politecnico di Milano, to devise an alternative plan aiming at preserving the social and typological characteristics of the complex, in order to enforce the sustainability and the direct involvement of the inhabitants in a process of participatory planning.
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A Silicon Hadron Calorimeter Module Operated in a Strong Magnetic Field with VLSI Readout for LHC
2002-01-01
% RD35 \\\\ \\\\ On the basis of a cost optimized Silicon production technology we proposed to build a hadron calorimeter active plane. \\\\ \\\\The production of detectors is closely followed and final quality control is performed according to specifications. \\\\ \\\\The technology designed for the cheap pad detector production is applied for the coarse strip detector manufacturing. These strip detectors will be used in the preshower of the electromagnetic calorimeter of CMS. \\footnote{Research & Prod. Assoc. ELMA, RSFSR} \\footnote{Byelorussian State Univ. Minsk} \\footnote{Research & Prod. Comp. SIAPS, RSFSR} \\footnote{Joffe Physical-Technical Inst. RSFSR} \\footnote{Ansaldo Richerche spa, Genoa} \\footnote{SGS-THOMSON, Castelletto, Milan}
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La dimension symbolique du capital social: les grandes cercles et Rotary clubs de Milan
Cousin, B.; Chauvin, S.
2010-01-01
Les cercles et clubs bourgeois des métropoles européennes ont jusqu'ici surtout fait l'objet de monographies isolées. Le cas milanais permet de passer à une analyse relationnelle : les institutions de gestion collective du capital social des classes dominantes y forment en effet un espace de jeu et
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Directory of Open Access Journals (Sweden)
J. P. Burrows
2010-09-01
Full Text Available Hazardous impact of air pollutant emissions from megacities on atmospheric composition on regional and global scales is currently an important issue in atmospheric research. However, the quantification of emissions and related effects is frequently a difficult task, especially in the case of developing countries, due to the lack of reliable data and information. This study examines possibilities to retrieve multi-annual NOx emissions changes in megacity regions from satellite measurements of nitrogen dioxide and to quantify them in terms of linear and nonlinear trends. By combining the retrievals of the GOME and SCIAMACHY satellite instrument data with simulations performed by the CHIMERE chemistry transport model, we obtain the time series of NOx emission estimates for the 12 largest urban agglomerations in Europe and the Middle East in the period from 1996 to 2008. We employ then a novel method allowing estimation of a nonlinear trend in a noisy time series of an observed variable. The method is based on the probabilistic approach and the use of artificial neural networks; it does not involve any quantitative a priori assumptions. As a result, statistically significant nonlinearities in the estimated NOx emission trends are detected in 5 megacities (Bagdad, Madrid, Milan, Moscow and Paris. Statistically significant upward linear trends are detected in Istanbul and Tehran, while downward linear trends are revealed in Berlin, London and the Ruhr agglomeration. The presence of nonlinearities in NOx emission changes in Milan, Paris and Madrid is confirmed by comparison of simulated NOx concentrations with independent air quality monitoring data. A good quantitative agreement between the linear trends in the simulated and measured near surface NOx concentrations is found in London.
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Energy Technology Data Exchange (ETDEWEB)
Xing, Minzhi [Yale School of Medicine, Interventional Radiology, Department of Radiology and Biomedical Imaging (United States); Sakaria, Sonali [Emory University School of Medicine, Division of Digestive Diseases, Department of Medicine (United States); Dhanasekaran, Renumathy [Stanford University School of Medicine, Division of Gastroenterology and Hepatology (United States); Parekh, Samir; Spivey, James [Emory University School of Medicine, Division of Digestive Diseases, Department of Medicine (United States); Knechtle, Stuart J. [Duke University School of Medicine, Division of Transplant Surgery, Department of Surgery (United States); Zhang, Di [University of Pittsburgh, Department of Biostatistics, Graduate School of Public Health (United States); Kim, Hyun S., E-mail: kevin.kim@yale.edu [Yale School of Medicine, Interventional Radiology, Department of Radiology and Biomedical Imaging (United States)
2017-03-15
Background and AimsTo evaluate the long-term survival benefit of bridging locoregional therapy (LRT) prior to orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria.MethodsOur transplant center registry was studied for all HCC patients within the Milan criteria who were listed for OLT from 1998 to 2013. Baseline clinical characteristics and median overall survival (OS) were calculated and stratified by LRT, OLT status, and wait times. Survival analysis was conducted using Kaplan–Meier estimation and log-rank test.ResultsOf 265 listed, 205 underwent OLT (mean follow-up 7.6 years). Of 205, 111 received bridging LRT (A), and 94 did not (B). Both were similar in demographics and tumor characteristics (p > 0.05). Median OS from HCC for A/B were 86.4 vs. 68.9 months (p = 0.01). Median OS from OLT for A/B were 74.6 vs. 63.6 months (p = 0.03). On multivariate analysis, independent predictors for survival from HCC were bridging LRT (p = 0.002) and high wait time (p = 0.008); independent predictors for survival from OLT were bridging LRT (p = 0.005) and high wait time (p = 0.005). Of 60 who were listed but did not undergo transplant, 44 received LRT (C) and 16 received best supportive care (D). Median OS from HCC for C/D were 37.1 vs. 24.8 months (p = 0.03).ConclusionsBridging LRT and high wait times were independent positive prognostic factors for survival from HCC diagnosis and OLT.
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Directory of Open Access Journals (Sweden)
Banfi P
2018-01-01
Full Text Available Paolo Banfi,1 Antonietta Cappuccio,2 Maura E Latella,3 Luigi Reale,2 Elisa Muscianisi,3 Maria Giulia Marini2 1Pneumological Rehabilitation, IRCCS Fondazione Don Gnocchi Onlus, Milan, Italy; 2Healthcare Area, Fondazione ISTUD, Milan, Italy; 3Medical Department, Novartis Farma Spa, Origgio, Italy Purpose: Poor adherence to therapy and the failure of current smoking cessation programs demonstrate that the current management of COPD can be improved, and it is necessary to educate physicians about new approaches for taking care of patients. Parallel chart is a narrative medicine tool that improves the doctor–patient relationship by asking physicians to write about their patients’ lives, thereby encouraging reflective thoughts on care. Patients and methods: Between October 2015 and March 2016, 50 Italian pulmonologists were involved in the collection of parallel charts of anonymous patients with COPD. The narratives were analyzed according to the Grounded Theory methodology. Results: In the 243 parallel charts collected, the patients (mean age 69 years, 68% men are described as still active and as a resource for their families (71%. The doctor–patient relationship started as difficult in 50% of cases, and younger age and smoking were the main risk factors. The conversations turned positive in 78% of narratives, displaying deeper mutual knowledge, trust for the clinicians’ ability to establish effective therapy (92%, support efforts to quit smoking (63%, or restore patients’ activities (78%.Conclusion: All the physicians concurred that the adoption of innovative parallel charts was useful for improving clinical care and worthy of official inclusion in protocols for the management of COPD. Keywords: narrative medicine, COPD, doctor–patient relationship, quality of life
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International Nuclear Information System (INIS)
Xing, Minzhi; Sakaria, Sonali; Dhanasekaran, Renumathy; Parekh, Samir; Spivey, James; Knechtle, Stuart J.; Zhang, Di; Kim, Hyun S.
2017-01-01
Background and AimsTo evaluate the long-term survival benefit of bridging locoregional therapy (LRT) prior to orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria.MethodsOur transplant center registry was studied for all HCC patients within the Milan criteria who were listed for OLT from 1998 to 2013. Baseline clinical characteristics and median overall survival (OS) were calculated and stratified by LRT, OLT status, and wait times. Survival analysis was conducted using Kaplan–Meier estimation and log-rank test.ResultsOf 265 listed, 205 underwent OLT (mean follow-up 7.6 years). Of 205, 111 received bridging LRT (A), and 94 did not (B). Both were similar in demographics and tumor characteristics (p > 0.05). Median OS from HCC for A/B were 86.4 vs. 68.9 months (p = 0.01). Median OS from OLT for A/B were 74.6 vs. 63.6 months (p = 0.03). On multivariate analysis, independent predictors for survival from HCC were bridging LRT (p = 0.002) and high wait time (p = 0.008); independent predictors for survival from OLT were bridging LRT (p = 0.005) and high wait time (p = 0.005). Of 60 who were listed but did not undergo transplant, 44 received LRT (C) and 16 received best supportive care (D). Median OS from HCC for C/D were 37.1 vs. 24.8 months (p = 0.03).ConclusionsBridging LRT and high wait times were independent positive prognostic factors for survival from HCC diagnosis and OLT.
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International Nuclear Information System (INIS)
Noro, M.; Lazzarin, R.M.
2014-01-01
This paper considers different cooling systems and investigates the most promising alternatives when solar energy is to be used to supply the cooling demand. All the systems are evaluated during a summer cooling season by the energetic and economic point of view by dynamic simulation for two different climates. For Milan (Cfb climate) the highest OSE (overall system efficiency) is reached by LiBr (lithium-bromide) double effect absorption chiller driven by parabolic through collector (0.53). In terms of the collecting surface area, the best systems for Milan feature 0.08 m 2 MJ −1 per day both for electric system (mono-crystalline photovoltaic coupled to water cooled chiller) and thermal system (PTC (parabolic trough collectors) coupled to double effect water-LiBr absorption chiller). Southern latitudes like Trapani (Csa climate) allow a quite better performance for thermal solar cooling solutions. The NPV (net present worths) of electric solar cooling solutions are favorable with respect to the traditional solution and the DPV (discounted payback periods) are all lower than the period of economic analysis above all for water cooled chillers. Finally a sensitivity analysis of the specific investment cost (€ MJ −1 per day) is carried out regarding the investment cost of collectors, the solar ratio and the interest rate. - Highlights: • Solar cooling is obtained with solar thermal or PV (photovoltaic) with easy available equipment. • In the past PV driven systems for solar cooling were not considered as too expensive. • An energy/economic comparison is carried out for the various solar cooling systems. • Sensitivity analyses are carried out varying different parameters
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Giacani, Lorenzo; Ciccarese, Giulia; Puga-Salazar, Christian; Dal Conte, Ivano; Colli, Laura; Cusini, Marco; Ramoni, Stefano; Delmonte, Sergio; DʼAntuono, Antonietta; Gaspari, Valeria; Drago, Francesco
2018-04-01
Although syphilis rates have been relatively high in Italy for more than 15 years, no data on the molecular types of Treponema pallidum subspecies pallidum circulating in this country are yet available. Likewise, no data on how widespread is resistance to macrolide or tetracycline antibiotics in these strains exist. Such data would, however, promote comprehensive studies on the molecular epidemiology of syphilis infections in Italy and inform future interventions aiming at syphilis control in this and other European countries. Swabs from oral, genital, cutaneous, or anal lesions were obtained from 60 syphilis patients attending dermatology clinics in Milan, Turin, Genoa, and Bologna. Molecular typing of T. pallidum DNA was performed to provide a snapshot of the genetic diversity of strains circulating in Northern Italy. Samples were also screened for mutations conferring resistance to macrolides and tetracyclines. T. pallidum DNA was detected in 88.3% (53/60) of the specimens analyzed. Complete and partial T. pallidum typing data were obtained for 77.3% (41/53) and 15.0% (8/53) of samples, respectively, whereas 4 samples could not be typed despite T. pallidum DNA being detected. The highest strain type heterogeneity was seen in samples from Bologna and Milan, followed by Genoa. Minimal diversity was detected in samples from Turin, despite the highest number of typeable samples collected there. Resistance to macrolides was detected in 94.3% (50/53) of the strains, but no known mutations associated with tetracycline resistance were found. Genetic diversity among T. pallidum strains circulating in Northern Italy varies significantly among geographical areas regardless of physical distance. Resistance to macrolides is widespread.
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[Industrial first aid equipment: a historical analysis (1840-1914) ].
Porro, Alessandro; Franchini, Antonia Francesca; Lorusso, Lorenzo; Falconi, Bruno
2015-01-09
Even if references to the tools required to intervene after an accident can be found in the works of Bernardino Ramazzini (1633-1714) or Johann Peter Frank (1745-1821), it was only with the development of industrial manufacturing that the need to study means to prevent and intervene in cases of accident became evident. In October 1894 the III Congrés International des Accidents du Travail et des Assurances Sociales was held in Milan. The following year, the Milanese trade union movement acknowledged the necessity to address the problem of industrial accidents. In 1896 the Association for Medical Assistance in Industrial Accidents was founded in Milan. A specific medical institute was set up, appropriate first aid tools were collected and first aid rooms in the main Milanese factories were inaugurated. Nevertheless, few data seem to be available regarding the manufacture and use of this equipment in industry. We analyzed more than fifty catalogs of European industrial products, between 1843 and 1914, to study the evolution of first aid equipment for industrial use. They reflect and attest to the evolution of medicine and surgery, although some models seem to be related to certain industrial categories (railways, electrical appliances), some were similar to ordinary first aid boxes, others were strictly related to surgery; some could only be used by physicians, and others only by workers. Identification, conservation, and reappraisal of these tools is essential for historians of occupational health because these objects were normally not preserved. The catalogues of industrial production are also precious sources, since they are rarely preserved in public libraries and deserve to be used for historical studies.
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Galassi, Marzia; Iavarone, Massimo; Rossi, Sandro; Bota, Simona; Vavassori, Sara; Rosa, Laura; Leoni, Simona; Venerandi, Laura; Marinelli, Sara; Sangiovanni, Angelo; Veronese, Letizia; Fraquelli, Mirella; Granito, Alessandro; Golfieri, Rita; Colombo, Massimo; Bolondi, Luigi; Piscaglia, Fabio
2013-05-01
Primary aim was to validate the percentage of intrahepatic cholangiocarcinomas (ICC) which have a contrast vascular pattern at contrast enhanced ultrasound (CEUS) at risk of misdiagnosis with hepatocellular carcinoma (HCC) and, secondary aim, to verify if any characteristics in the CEUS pattern helps to identify ICC. All ICC on cirrhosis seen in three Italian centres (Bologna, Milan and Pavia) between 2003 and 2011, in which CEUS and at least another imaging technique (CT or MRI) had been performed, were retrospectively identified. Those patients with ICC size comparable to the early HCC stage (Milan criteria, considered as small ICC) were enrolled for this study. The enhancement pattern at CEUS was analysed and compared with CT or MRI. A total of 25 small ICC made this study group. CEUS was at risk of misdiagnosis of ICC for HCC in a significantly higher number of cases than in CT (performed in 24 ICC) (52% vs. 4.2%, P = 0.009) and MRI (11 ICC) (52% vs. 9.1%, P = 0.02). A different contrast pattern among all techniques was found in 6 of 10 ICC lesions submitted to the three imaging methods. In the arterial phase, ICC lacked global hyperenhacement in approximately 50% of cases at CEUS and the degree of intensity of wash-out in the late phase was marked in 24% of nodules. CEUS misdiagnosed as HCC a significantly higher number of ICC lesions in cirrhotic patients than CT and MRI. However, some CEUS contrast features can help suspect ICC, especially in some cases with inconclusive CT or MRI. © 2013 John Wiley & Sons A/S.
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Therapeutic landscape for ulcerative colitis: where is the Adacolumn® system and where should it be?
Directory of Open Access Journals (Sweden)
D’Incà R
2013-01-01
Full Text Available Maurizio Vecchi,1 Piero Vernia,2 Gabriele Riegler,3 Renata D'Incà,4 Vito Annese,5 Siro Bagnoli51University of Milan, Department of Biomedical Sciences for Health, San Donato Milanese, Milan, 2Sapienza University of Rome, Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Rome, 3Second University of Naples, Gastroenterology and Endoscopy Unit, Naples, 4University of Padua, Department of Surgical and Gastroenterological Science, Gastroenterology Unit, Padua, 5University Hospital Careggi, Gastroenterology Unit, Florence, ItalyAbstract: Granulocyte-monocyte apheresis is a relatively new therapy that has been proposed, sometimes with controversial results, for the treatment of inflammatory bowel disease, particularly ulcerative colitis. The aim of the present study was to perform a thorough review of the literature on the application of this type of treatment in ulcerative colitis and discuss the results, in order to provide an opinion on its use which is shared by the involved experts. The review of the literature was performed by searching PubMed with appropriate key words. The results obtained suggest that the major role for this treatment at this moment is for those patients with steroid dependency or with major contraindications to use of steroids. However, promising, albeit very preliminary, results have also been observed in steroid-naïve subjects, and this is of particular interest in consideration of the safety profile of this therapeutic method. As such, the Adacolumn may prove useful in specific subgroups of patients. Future phenotypic, genotypic, and molecular characterization of patients with inflammatory bowel disease might prove useful in defining better those subjects who might benefit most from this treatment modality.Keywords: ulcerative colitis, inflammatory bowel disease, guidelines, apheresis
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Directory of Open Access Journals (Sweden)
Marta Nobile
2013-07-01
Full Text Available Background. The Center for Transfusion Medicine, Cell Therapy and Cryobiology, Milan, Northern Italy, is the headquarter of the POLI-MI biobank. It co-ordinates the biobank activities of the Fondazione Ca’ Granda Ospedale Maggiore Policlinico of Milan. Such activities require specific safeguarding of donors’ rights and protection of sensitive and genetic data. The Fondazione Ca’ Granda Ospedale Maggiore Policlinico has set up a project on informed consent with the aim of developing awareness and understanding of this issue. Within this project, it has been decided to evaluate how consent for biobanking material is expressed. Design and methods. The aim of the study was to evaluate the quality and completeness of consent to biobanking in the POLI-MI biobank. This was a retrospective study carried out in 2012 on samples of consent declarations collected by biobank units in 2011. Some units used a single, standard consent model available from a previous POLI-MI biobank workgroup. Other units used models which had been previouly formulated. Evaluation was made using a form that indicated the essential elements of consent. Results. A total of 48 consent declarations were collected using the single, standard model and 84 were collected using other models. The consent declarations that used the single, standard model were found to be the most complete and were filled in better than other models. Conclusions. Progressive adoption of a simple, standard consent model is expected to improve the quality of consent acquisition. Regular audit of the compliance of consent practices with ethical and legal requirements is mandatory to improve the quality of research biobanking.
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The correlation between stress and economic crisis: a systematic review
Directory of Open Access Journals (Sweden)
Mucci N
2016-04-01
Full Text Available Nicola Mucci,1 Gabriele Giorgi,2 Mattia Roncaioli,3 Javier Fiz Perez,2 Giulio Arcangeli11Department of Experimental and Clinical Medicine, University of Florence, Florence, 2Department of Psychology, European University of Rome, Rome, 3Department of Biomedical Sciences for Health, University of Milan, Milan, ItalyAbstract: In 2008 a deep economic crisis started in the US and rapidly spread around the world. The crisis severely affected the labor market and employees’ well-being. Hence, the aim of this work is to implement a systematic review of the principal studies that analyze the impact of the economic crisis on the health of workers. We conducted our search on the PubMed database, and a total of 19 articles were selected for review. All studies showed that the economic crisis was an important stressor that had a negative impact on workers’ mental health. Most of the studies documented that a rise in unemployment, increased workload, staff reduction, and wages reduction were linked to an increased rate of mood disorders, anxiety, depression, dysthymia, and suicide. Some studies showed that problems related to the crisis may have also affected the general health of workers by increasing the risk of such health problems as cardiovascular and respiratory diseases. Finally, some studies looked at the impact of the crisis on health care services. These studies demonstrated that the reduction in public expenditure on health care services, and the reduction of public hospital budgets due to the recession, led to organizational problems (eg, medical supply shortages.Keywords: economic crisis, recession, work-related stress, mental health, risks assessment, occupational medicine
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Manzini, Giulia; Henne-Bruns, Doris; Porzsolt, Franz; Kremer, Michael
2017-01-01
Liver resection (LR) and transplantation are the most reliable treatments for hepatocellular carcinoma (HCC). Aim was to compare different guidelines regarding indication for resection and transplantation because of HCC with and without underlying cirrhosis. We compared the following guidelines published after 1 January 2010: American (American Association for the Study of Liver Diseases (AASLD)), Spanish (Sociedad Espanola de Oncologia Medica (SEOM)), European (European Association for the study of liver-European Organization for Research and Treatment of Cancer (EASL-EORTC) and European Society for Medical Oncology-European Society of Digestive Oncology (ESMO-ESDO)), Asian (Asian Pacific Association for the Study of Liver (APASL)), Japanese (Japan Society of Hepatology (JSH)), Italian (Associazione Italiana Oncologia Medica (AIOM)) and German (S3) guidelines. All guidelines recommend resection as therapy of choice in healthy liver. Guidelines based on the Barcelona Clinic Liver Cancer staging system recommend resection for single HCCguidelines recommend LR for patients with Child-Pugh A/B with HCC without tumour size restriction; APASL guidelines in general exclude patients with Child-Pugh A from transplantation. In patients with Child-Pugh B, transplantation is the second-line therapy, if resection is not possible for patients within Milan criteria. German and Italian guidelines recommend transplantation for all patients within Milan criteria. Whereas resection is the standard therapy of HCC in healthy liver, a standard regarding the indication for LR and transplantation for HCC in cirrhotic liver does not exist, although nearly all guidelines claim to be evidence based. Surprisingly, despite European guidelines, Germany and Italy use their own national guidelines which partially differ from the European. Possible solutions of the problems are discussed.
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Ethical and cultural value of the Earth sciences. Interview with Prof. Giulio Giorello
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Silvia Peppoloni
2012-07-01
Full Text Available Prof. Giulio Giorello is amongst the most prominent philosophers of science in Italy and in the world. He is currently Professor of the Philosophy of Science at the University of Milan, Director of the Series ‘Science and Ideas’ (Raffaele Cortina Books Editor, and Literary Journalist of the cultural pages of the Corriere della Sera, one of the most important of the Italian newspapers. In this keynote presentation, in interview form, he talks about the value that the Earth sciences have had through history, framing this group of disciplines in ethical and epistemological terms, and highlighting some important elements that have to be considered in geological activities.
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Weak oil prices seen hindrance to pace of increase in gas use
International Nuclear Information System (INIS)
Anon.
1994-01-01
World demand for gas is expected to rocket, yet future natural gas and liquefied natural gas projects remain threatened by the link of gas prices to crude oil prices. This is the main message that emerged from the 19th World Gas Conference in Milan last week. A number of reports predicted regional demand for gas. All foresaw a rise. International Gas Union (IGU), organizer of the conference, and said world natural gas production has continued to rise despite a significant downturn in industrial production. The paper discusses gas demand in Europe, the correlation between oil and gas prices, the natural gas industry in Indonesia, Russia, and southern Europe
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Clinical applications of an ATM/Ethernet network in departments of neuroradiology and radiotherapy.
Cimino, C; Pizzi, R; Fusca, M; Bruzzone, M G; Casolino, D; Sicurello, F
1997-01-01
An integrated system for the multimedia management of images and clinical information has been developed at the Isituto Nazionale Neurologico C. Besta in Milan. The Institute physicians have the daily need of consulting images coming from various modalities. The high volume of archived material and the need of retrieving and displaying new and past images and clinical information has motivated the development of a Picture Archiving and Communication System (PACS) for the automatic management of images and clinical data, related not only to the Radiology Department, but also to the Radiotherapy Department for 3D virtual simulation, to remote teleconsulting, and in the following to all the wards, ambulatories and labs.
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International Nuclear Information System (INIS)
Galimberti, E.; Baroni, R.; Villa, V.; Sesana, G.
1999-01-01
This paper reports the result concerning the air quality evaluation in an urban centre in the hinterland of Milan., with an high population density and an intense road traffic, relatively to polycyclic aromatic hydrocarbons (PAH) concentration levels. The data, referred to the annual season, indicate that, near high traffic road, the above compounds are always present in the concentration level analytically detectable and that the concentration of benzo(a)pyrene is 2.7 ng/m 3 . The reported study is an useful instruments both for a road town planning, in order to people disease prevention, and for monitoring the evolution of PAH concentration levels in the future [it
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LAZA K. LAZAREVIC, DOCTOR AND WRITER
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Rade R. Babić
2006-04-01
Full Text Available Laza K. Lazarevic was born on the 13th of May in 1851. He died on the 11th of January in 1891 in Belgrade. Laza K. Lazarevic was a Serb, jurist, warrior, doctor and writer. He studied medicine in Berlin and law in Belgrade. He took part in the Serbian-Turkish war and the Serbian-Bulgarian war. He published seventy-two professional and scientific papers on medicine. He gave some explanations on the appearance of pain in sciatica. He wrote nine short stories. He is an Associate Member of the Serbian Royal Academy. He spoke Russian, German and French. He was a personal doctor of King Milan.
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Report on nuclear and radiation safety in Slovenia in 1997
International Nuclear Information System (INIS)
1998-06-01
The Slovenian Nuclear Safety Administration (SNSA), in co-operation with the Health Inspectorate of the Republic of Slovenia, the Administration for Civil Protection and Disaster Relief and the Ministry of the Interior, has prepared a Report on Nuclear and Radiation Safety in the Republic of Slovenia for 1997. This is one of the regular forms of reporting on the work of the Administration to the Government and National Assembly of the Republic of Slovenia. Contributions to the report were furthermore prepared by competent authorities in the field of nuclear safety: the Agency for Radwaste Management (ARAO), the Milan Copic Nuclear Training Centre, etc. The report contains 19 chapters.
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Design, Production, and Installation of Wooden Walls for the Japan Pavilion at Expo 2015
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Matteo Cipollini
2016-10-01
Full Text Available This article illustrates the production process, the structural calculations and the assembly phases of the wooden walls of the Japan Pavilion at Expo 2015 in Milan, designed by Atsushi Kitagawara Architects (AKA. The pavilion, one of the most popular construction of this international event, was built almost exclusively with precast interlocking. The production process and the assembly phases were optimized to construct the wooden walls (with a height of 4–12 m in a short time frame and with a high level of quality. Out-of-plane rocking and other aspects of structural safety were considered, to ensure sufficient stability of the walls.
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Suzana Marjanić
2018-05-01
Full Text Available Speaking in a global context, the media’s sacred trinity, in the sense of gaining publicity and financing their programs, certainly makes up gossip, focuses on war (of course, the American matrix of war against so-called terrorism and finally conspiracy theories. As it is well-known, it is all about content that sells well. The abovementioned triad is presented on the cases of performance art by local artists/ performance artists (on the example of their criticism of the said material – Milan Božić, Boris Demur, Željko Kipke, Tomislav Gotovac aka Antonio G. Lauer i Siniša Labrović.
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Nuclear and radiation safety in Slovenia. Annual report 1997
International Nuclear Information System (INIS)
1998-01-01
The Slovenian Nuclear Safety Administration (SNSA), in co-operation with the Health Inspectorate of the Republic of Slovenia, the Administration for Civil Protection and Disaster Relief and the Ministry of the Interior, has prepared a Report on Nuclear and Radiation Safety in the Republic of Slovenia for 1997. This is one of the regular forms of reporting on the work of the Administration to the Government and National Assembly of the Republic of Slovenia. Contributions to the report were furthermore prepared by competent authorities in the field of nuclear safety: the Agency for Radwaste Management (ARAO), the Milan Copic Nuclear Training Centre, etc. The report contains 17 chapters. (author)
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Lingua, memoria e identità nei racconti dei migranti ispanoamericani
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Maria Vittoria Calvi
2014-06-01
Full Text Available In a wide-ranging theoretical framework, principally based upon discourse analysis and the studies on language and identity, this article explores the construction of identity in a corpus of oral narratives collected among the Spanish speaking communities in Milan, by means of sociolinguistic and biographic interviews, seen as a complex event in which both parties act as active participant-observers. The study focuses on the features of these life stories, taking into account the ways in which the immigrants compare the two worlds an collocates themselves between the two cultures, the function of code-switching, the linguistic expression of ‘agency’ (Giddens 1979 and the use of deictics.
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Public opinion about nuclear energy. Year 2006 poll
International Nuclear Information System (INIS)
Istenic, R.; Jencic, I.; Tkavc, M.
2006-01-01
Public information, one of the important activities of the Nuclear Training Centre Milan Copic at the Jozef Stefan Institute in Ljubljana, is focused on youngsters. Almost one half of every generation of schoolchildren in Slovenia is informed on nuclear energy by live lectures, exhibition, publications and laboratory demonstrations. To measure the opinion of youngsters about nuclear power and get a feed-back for our activities about 1000 youngsters are polled every year since 1993 using the same basic set of questions. Continued operation of the NPP Krsko is supported by 76% of youngsters in Slovenia (slightly positive trend from the last year's 71%). Opposition to NPP Krsko operation remains low. (author)
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Signoles Aude, Le Hamas au pouvoir et après ?, Toulouse, Editions Milan, 2006.
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Jean-François Legrain
2007-11-01
Full Text Available Dans les étroites limites imposées par la collection (absence totale de notes et de bibliographie, 112 p. en format réduit, le petit livre d’Aude Signoles, Le Hamas au pouvoir et après ?, commence à combler un vide de l’édition française. Le seul livre jusque là disponible en français et entièrement consacré à Hamas remonte à 7 années maintenant ; doté de nombreuses erreurs factuelles et faisant comme si Hamas était apparu avec l’autonomie des années 1990, il ignorait tout de son passé d’Ass...
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Solano, G.
2016-01-01
This dissertation investigates the relationship between transnational practices and immigrant entrepreneurship, focusing more closely on immigrant entrepreneurs who own a business spanning across borders (i.e. transnational immigrant entrepreneurship), and comparing them with the general category of
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MOBILE APPLICATIONS AS TOOL FOR EXPLOITING CULTURAL HERITAGE IN THE REGION OF TURIN AND MILAN
A. Rolando; A. Scandiffio
2013-01-01
The current research aims at showing as applications working on personal mobile communication terminals such as smartphones, can be useful for exploration of places and, at the same time, as tools able to develop interaction between cultural heritage and users. In this sense, the use of smartphone applications can be combined with GIS in order to make a platform of knowledge useful to support research studies in the field of cultural heritage, with specific reference to accessibility...
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The "Trotter" Open-Air School, Milan (1922-1977): A City of Youth or Risky Business?
Thyssen, Geert
2009-01-01
This article inserts the concept of risk in the context of open-air schools and investigates its implications, capacities and limits. It is contended that applying at-risk labels to pupils who attended open-air schools is itself a risky business. The category to some extent constitutes an anomaly within most open-air schools' histories, as much of…
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--- Various Authors
2017-09-01
Full Text Available Selected Lectures of the XXIII National Congress of the Italian Society of Neonatology (Società Italiana di Neonatologia, SIN; Milan (Italy; September 25-28, 2017Guest Editor: Mauro StronatiLECT 1. COMPLEMENTARY FEEDING IN PRETERM INFANTS: MYTHS AND FACTS • A. AcetiLECT 2. NEONATAL HYDRONEPHROSIS • R. AgostinianiLECT 3. WHEN A NEWBORN DIES IN NICU • M. Susi, S. Dosso, A. Anselmi, A. Bertolini, P. BibanLECT 4. RED REFLEX TESTING IMPLEMENTATION IN THE NURSERY: COMPARING EXPERIENCES • G. Araimo, S.G. Osnaghi, M. Colombo, G. Regiroli, L. Colombo, F. MoscaLECT 5. PAIN MANAGEMENT IN PREMATURE INFANTS. PAIN SEMIOLOGY AND ASSESSMENT. ANALGESIA FOR SKIN BREAKING PROCEDURES • I. ArengaLECT 6. VISUAL EVOKED POTENTIALS: WHY AND WHEN PERFORM THEM • A. Baldascino, G. Amorelli, D. Lepore, F. Molle, G. D’Amico, A. CaporossiLECT 7. NURSING NEONATES SUPPORTED ON ECMO: ORGANIZATIONAL FEATURES AND CARING ASPECTS • C. Baracetti, G. Cavallaro, G. Raffaeli, L. Plevani, F. MoscaLECT 8. NEONATAL HYPO- AND HYPERGLYCEMIA: WHAT TO KNOW, WHAT TO DO • G. Barera, G. CassanoLECT 9. THE ESSENTIAL CARE LEVELS: INDICATIONS FOR THE NEWBORN • S. BattilomoLECT 10. VITAMIN D: OLD AND NEW • A. Boldrini, M. Del PistoiaLECT 11. NURSING-SENSITIVE OUTCOMES IN NEONATOLOGY • L. Boni, G. GarganoLECT 12. REQUIREMENTS OF MACRONUTRIENTS AND MINERALS IN PARENTERAL NUTRITION OF PRETERM INFANTS • V. Bozzetti, P.E. TagliabueLECT 13. KANGAROO MOTHER CARE (KMC AND NEUROPROTECTION • G. Calciolari, C. Artese, N. Bertoncelli, E. Beccaria, V. Chiandotto, G. Colombo, S. De Marca, R. Montirosso, G. Paterlini, N. Simeone, F. FerrariLECT 14. HEMODYNAMIC PRINCIPLES AND MANAGEMENT OF EXTRACORPOREAL MEMBRANE OXYGENATION SUPPORT • F. Canesi, F. Conigliaro, R. Fierro, G. Cavallaro, G. Raffaeli, F. MoscaLECT 15. THE STABILIZATION OF THE NEWBORN BEFORE THE TRANSPORT • V. Cardilli, P. Repole, S. Caoci, R. CellittiLECT 16. NEONATAL EXTRACORPOREAL MEMBRANE OXYGENATION
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Jones, Graham R D; Albarede, Stephanie; Kesseler, Dagmar; MacKenzie, Finlay; Mammen, Joy; Pedersen, Morten; Stavelin, Anne; Thelen, Marc; Thomas, Annette; Twomey, Patrick J; Ventura, Emma; Panteghini, Mauro
2017-06-27
External Quality Assurance (EQA) is vital to ensure acceptable analytical quality in medical laboratories. A key component of an EQA scheme is an analytical performance specification (APS) for each measurand that a laboratory can use to assess the extent of deviation of the obtained results from the target value. A consensus conference held in Milan in 2014 has proposed three models to set APS and these can be applied to setting APS for EQA. A goal arising from this conference is the harmonisation of EQA APS between different schemes to deliver consistent quality messages to laboratories irrespective of location and the choice of EQA provider. At this time there are wide differences in the APS used in different EQA schemes for the same measurands. Contributing factors to this variation are that the APS in different schemes are established using different criteria, applied to different types of data (e.g. single data points, multiple data points), used for different goals (e.g. improvement of analytical quality; licensing), and with the aim of eliciting different responses from participants. This paper provides recommendations from the European Federation of Laboratory Medicine (EFLM) Task and Finish Group on Performance Specifications for External Quality Assurance Schemes (TFG-APSEQA) and on clear terminology for EQA APS. The recommended terminology covers six elements required to understand APS: 1) a statement on the EQA material matrix and its commutability; 2) the method used to assign the target value; 3) the data set to which APS are applied; 4) the applicable analytical property being assessed (i.e. total error, bias, imprecision, uncertainty); 5) the rationale for the selection of the APS; and 6) the type of the Milan model(s) used to set the APS. The terminology is required for EQA participants and other interested parties to understand the meaning of meeting or not meeting APS.
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Serbs in political and military elites of the Ustaše's Independent State of Croatia
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Atlagić Marko P.
2014-01-01
Full Text Available The phenomenon of Serbian participation in the political and military elites and leadership of the Independent State of Croatia was not enough or rather not at all scientifically analysed and researched. The purpose of this paper is to inspire the historians of our recent past to research and critically evaluate the problems. In the beginning of the war during the establishment of the Independent State of Croatia, the Serbs were not involved in the Home Guard units as regular armed forces of Independent State of Croatia. Along with the development of the Independent Ustaš State of Croatia, the necessity for Serbian participation in Home Guard units arose. The Serbs were mainly educated in Austro-Hungarian schools for officers. They also participated in the armed forces of the Kingdom of Serbs, Croats and Slovenes i.e. the Kingdom of Yugoslavia. The most prominent among them were: Dr Savo Besarović, general Teodor Dragojlov, general Đuro Dragičević, general Đuro Grujić, a knight, general Milan Desović, general Mihailo Lukić, general Dušan Palčić, general Miroslav Opačić (Fridrich, a church official Zvonimir Stimaković, general Miloš Obrknežević, Minister without portfolio Ljubomir Antić, general Lalislav Milić, general Milan Uzelac and others. Apart from being the most prominent ones in the Home Guard units, there were Serbs in the political elites of the Independent State of Croatia, as well as in the Presidency of the Parliament and in the positions of the Ministers in the Independent State of Croatia. This phenomenon should be an example for future generations, in a case of war, not to happen that one part of the people takes the enemy side because the greatest sin ever is to betray its own people and country.
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Impact of Scattering Model on Disdrometer Derived Attenuation Scaling
Zemba, Michael; Luini, Lorenzo; Nessel, James; Riva, Carlo (Compiler)
2016-01-01
NASA Glenn Research Center (GRC), the Air Force Research Laboratory (AFRL), and the Politecnico di Milano (POLIMI) are currently entering the third year of a joint propagation study in Milan, Italy utilizing the 20 and 40 GHz beacons of the Alphasat TDP5 Aldo Paraboni scientific payload. The Ka- and Q-band beacon receivers were installed at the POLIMI campus in June of 2014 and provide direct measurements of signal attenuation at each frequency. Collocated weather instrumentation provides concurrent measurement of atmospheric conditions at the receiver; included among these weather instruments is a Thies Clima Laser Precipitation Monitor (optical disdrometer) which records droplet size distributions (DSD) and droplet velocity distributions (DVD) during precipitation events. This information can be used to derive the specific attenuation at frequencies of interest and thereby scale measured attenuation data from one frequency to another. Given the ability to both predict the 40 GHz attenuation from the disdrometer and the 20 GHz timeseries as well as to directly measure the 40 GHz attenuation with the beacon receiver, the Milan terminal is uniquely able to assess these scaling techniques and refine the methods used to infer attenuation from disdrometer data.In order to derive specific attenuation from the DSD, the forward scattering coefficient must be computed. In previous work, this has been done using the Mie scattering model, however, this assumes a spherical droplet shape. The primary goal of this analysis is to assess the impact of the scattering model and droplet shape on disdrometer derived attenuation predictions by comparing the use of the Mie scattering model to the use of the T-matrix method, which does not assume a spherical droplet. In particular, this paper will investigate the impact of these two scattering approaches on the error of the resulting predictions as well as on the relationship between prediction error and rain rate.
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Moschouris, Hippocrates; Malagari, Katerina; Marinis, Athanasios; Kornezos, Ioannis; Stamatiou, Konstantinos; Nikas, Georgios; Papadaki, Marina Georgiou; Gkoutzios, Panagiotis
2012-01-01
AIM: To evaluate the response of hepatocellular carcinoma (HCC) to transarterial chemoembolization (TACE) using a simplified protocol of parametric contrast-enhanced ultrasound (pCEUS). METHODS: Eighteen patients with HCC (18 target tumors, diameter: 2.8-12 cm) were evaluated before, and 20 d after TACE. The distribution and morphology of TACE-induced necrosis in these tumors precluded accurate evaluation by visual assessment or by simple measurements. For pCEUS, a 4.8 mL bolus of SonoVue (Bracco, Milan, Italy) was intravenously administered and analysis of tumor perfusion during the initial phase of enhancement (0-30 s post injection) was performed with dedicated software (Qontrast, Bracco, Milan, Italy). Time-intensity curves were plotted and three parameters were calculated: peak intensity (PI, in percentage %), time to peak (TTP in seconds, s) and area under the curve during wash-in (AUC-WI, in arbitrary units, a.u). Magnetic resonance imaging was the standard imaging modality for post-treatment evaluation. Changes in tumor size were recorded and response was assessed according to response evaluation criteria in solid tumors criteria. RESULTS: A statistically significant decrease in PI and AUC-WI was observed in the treated tumors post TACE; PIpre: 21.5% ± 8.7% (mean ± SD), PIpost: 12.7% ± 6.7%, P < 0.001, AUC-WI pre: 17493 ± 9563 a.u, AUC-WI post: 9585 ± 5494 a.u, P < 0.001. A slight increase in TTP was noted post TACE, but this was not statistically significant; TTP pre: 13.1 ± 4.3 s, TTP post: 13.6 ± 4.2 s , P = 0.058). The changes in the aforementioned parameters were not accompanied by significant tumor shrinkage. CONCLUSION: pCEUS, even when limited to the study of the arterial phase of tumoral enhancement, can detect and quantify early perfusional changes in HCC post TACE. PMID:22937217
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Surgical Treatment of Hepatocellular Carcinoma
Zamora-Valdes, Daniel; Taner, Timucin; Nagorney, David M.
2017-01-01
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. In select patients, surgical treatment in the form of either resection or transplantation offers a curative option. The aims of this review are to (1) review the current American Association for the Study of Liver Diseases/European Association for the Study of the Liver guidelines on the surgical management of HCC and (2) review the proposed changes to these guidelines and analyze the strength of evidence underlying these proposals. Three authors identified the most relevant publications in the literature on liver resection and transplantation for HCC and analyzed the strength of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification. In the United States, the liver allocation system provides priority for liver transplantation to patients with HCC within the Milan criteria. Current evidence suggests that liver transplantation may also be indicated in certain patient groups beyond Milan criteria, such as pediatric patients with large tumor burden or adult patients who are successfully downstaged. Patients with no underlying liver disease may also benefit from liver transplantation if the HCC is unresectable. In patients with no or minimal (compensated) liver disease and solitary HCC ≥2 cm, liver resection is warranted. If liver transplantation is not available or contraindicated, liver resection can be offered to patients with multinodular HCC, provided that the underlying liver disease is not decompensated. Many patients may benefit from surgical strategies adapted to local resources and policies (hepatitis B prevalence, organ availability, etc). Although current low-quality evidence shows better overall survival with aggressive surgical strategies, this approach is limited to select patients. Larger and well-designed prospective studies are needed to better define the benefits and limits of such approach. PMID:28975836
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Prevalence of child sexual abuse: a comparison among 4 Italian epidemiological studies
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Beatrice Castelli
2015-11-01
Full Text Available Although many epidemiological studies defining child sexual abuse prevalence rates in many countries of the world are now available, Italy presents a lack of data regarding this specific issue. Only recently some attempts to define the epidemiology of this public health problem have been tried. Between 2003 and 2010, the Department of Public Health at University of Milan was in charge of one of the more important study of this kind in Italy, involving almost 3000 students aged 18 attending secondary schools in the City of Milan who filled out an anonymous questionnaire aiming at detecting their previous experiences of sexual victimization during childhood and adolescence. After this first edition, the study was replicated among students attending secondary schools in the city of Varese, in the area of Piedmont and in Basilicata (area of Lauria, using the same investigational model and questionnaire. This paper presents the main data collected through four different epidemiological studies using the same methodology and survey tool. Considering at least one of the five different forms of child sexual abuse surveyed (being exposed to pornography, being touched on private parts, being forced to masturbate an older person, being forced to perform oral sex, or being penetrated, the prevalence rate among our samples ranges between a minimum of 12.5% (Varese and a maximum of 34.1% (Lauria. In Lauria the research reveals a higher prevalence rate of child sexual abuse, especially among the male population, for all typologies of abuse but being touched in their private parts. In all other geographical areas and for all typologies of abuse, there is always a higher prevalence among girls, with the only exception of abuse such as being exposed to pornographic materials.
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Pitfalls in surveillance for hepatocellular carcinoma: How successful is it in the real world?
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Linda L. Wong
2017-09-01
Full Text Available Background/Aims Surveillance for hepatocellular carcinoma (HCC with ultrasound in high-risk populations is generally believed to improve opportunities for treatment. However, tumors are still missed due to various factors. This study explores success versus failure of HCC surveillance. Methods This is a retrospective study of 1,125 HCC cases. Categories considered for successful detection were largest tumor ≤3.0 cm, single tumors ≤3.0 cm and ≤2.0 cm, and adherence to Milan criteria. Examined factors were age <60 years, gender, rural residence, body-mass index (BMI, hepatitis infection, smoking, diabetes, hyperlipidemia, cirrhosis, ascites, and Model for End-Stage Liver Disease <10. Results HCC was found on surveillance in 257 patients with a mean tumor size of 3.17 cm; multiple tumors were seen in 28% of cases, bilateral tumors in 7.4%, and vascular invasion in 3.7%. Surveillance was successful in 61.5% of cases involving a largest tumor ≤3.0 cm, with BMI ≥35 negatively affecting detection (odds ratio [OR] 0.28, P=0.014 and cirrhosis positively affecting detection (OR 2.31, P=0.036. Ultrasound detected 19.1% of single tumors ≤2.0 cm with ascites improving the detection rate (OR 3.89, P=0.001. Finally, adherence to Milan criteria occurred in 75.1% of cases, revealing negative associations with diabetes (OR 0.48, P=0.044 and male gender (OR 0.49, P=0.08. Conclusions Although surveillance is recommended for HCC, not all surveillance ultrasound are ideal. Tumor detection can depend on gender, BMI, diabetes, cirrhosis, and ascites and is achieved in 19.1–75% of cases depending on the definition of success. Closer follow-up or additional imaging might be necessary for some patient subgroups.
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Hudziak, J J; Boffeli, T J; Kreisman, J J; Battaglia, M M; Stanger, C; Guze, S B; Kriesman, J J
1996-12-01
The criteria for borderline personality disorder seem to select patients with very high rates of Briquet's syndrome (hysteria), somatization disorder, antisocial personality disorder, and substance abuse disorders. This study was undertaken to determine whether systematic assessment of patients with borderline personality disorder would reveal characteristic features of that condition which would distinguish it from these other disorders. Eighty-seven white female patients (75 in St. Louis and 12 in Milan, Italy) who had borderline personality disorder according to both the DSM-III-R criteria and the Revised Diagnostic Interview for Borderlines were further examined with the DSM-III-R Checklist and the Perley-Guze Hysteria Checklist to determine their patterns of psychiatric comorbidity. Every patient had at least one additional DSM diagnosis. Patients in St. Louis and Milan averaged five and four additional diagnoses, respectively. Eighty-four percent of the patients in St. Louis met criteria for either somatization disorder, Briquet's syndrome, antisocial personality disorder, or substance abuse disorders. Patterns of comorbidity for panic (51%), generalized anxiety disorder (55%), and major depression (87%) in St. Louis were consistent with those in other studies. The data indicate that the boundaries for the borderline condition are not specific and identify a high percentage of patients with these other disorders. Furthermore, the comorbidity profiles closely resemble the psychiatric profiles of patients with these disorders. If the borderline syndrome is meant to include all of these disorders, its usefulness as a diagnosis is limited. Until the fundamental features of borderline personality disorder that distinguish it from the others are identified, it is recommended that clinicians carefully assess patients for these other diagnoses. Efforts should be made to change the borderline personality disorder criteria by shifting away from overlap with the
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MOBIDIC-U: a watershed-scale model for stormwater attenuation through green infrastructures design
Ercolani, G.; Masseroni, D.; Chiaradia, E. A.; Bischetti, G. B.; Gandolfi, C.; Castelli, F.
2017-12-01
Surface water degradation resulting from the effects of urbanization on hydrology, water quality, habitat as well as ecological and environmental compartments represents an issue of primary focus for multiple agencies at the national, regional and local levels. Many management actions are needed throughout urban watersheds to achieve the desired effects on flow mitigation and pollutant reduction, but no single standardized solution can be effective in all locations. In this work, the distributed hydrological model MOBIDIC, already applied for hydrological balance simulations and flood prevention in different Italian regions, is adapted to the urban context (MOBIDIC-U) in order to evaluate alternative plans for stormwater quality management and flow abatement techniques through the adoption of green infrastructures (GIs). In particular the new modules included in MOBIDIC-U allow to (i) automatically define the upstream flow path as well as watershed boundary starting from a selected watershed closure point on the urban drainage network and (ii) obtain suitable graphical outputs for the visualization of flow peak and volume attenuation at the closure point. Moreover, MOBIDIC-U provides a public domain tool capable of evaluating the optimal location, type, and cost of the stormwater management practices needed to meet water quantity and quality goals. Despite the scalability of the model to different urban contexts, the current version of MOBIDIC-U has been developed for the area of the metropolitan city of Milan, Northern Italy. The model is implemented on a GIS platform, which already contains (i) the structure of the urban drainage network of the metropolitan city of Milan; (ii) the database of actual geomorphological and meteorological data for the previous domain (iii) the list of potential GIs, their standard size, installation and maintenance costs. Therefore, MOBIDIC-U provides an easy to use tool to local professionals to design and evaluate urban stormwater
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Directory of Open Access Journals (Sweden)
Ju-Yeon Cho
2016-12-01
Full Text Available Background/Aims Radiofrequency ablation (RFA is one of the most frequently applied curative treatments in patients with a single small hepatocellular carcinoma (HCC. However, the clinical significance of and risk factors for early massive recurrence after RFA—a dreadful event limiting further curative treatment—have not been fully evaluated. Methods In total, 438 patients with a single HCC of size ≤3 cm who underwent percutaneous RFA as an initial treatment between 2006 and 2009 were included. Baseline patient characteristics, overall survival, predictive factors, and recurrence after RFA were evaluated. In addition, the incidence, impact on survival, and predictive factors of early massive recurrence, and initial recurrence beyond the Milan criteria within 2 years were also investigated. Results During the median follow-up of 68.4 months, recurrent HCC was confirmed in 302 (68.9% patients, with early massive recurrence in 27 patients (6.2%. The 1-, 3-, and 5-year overall survival rates were 95.4%, 84.7%, and 81.8%, respectively, in patients with no recurrence, 99.6%, 86.4%, and 70.1% in patients with recurrence within the Milan criteria or late recurrence, and 92.6%, 46.5%, and 0.05% in patients with early massive recurrence. Multivariable analysis identified older age, Child-Pugh score B or C, and early massive recurrence as predictive of poor overall survival. A tumor size of ≥2 cm and tumor location adjacent to the colon were independent risk factors predictive of early massive recurrence. Conclusions Early massive recurrence is independently predictive of poor overall survival after RFA in patients with a single small HCC. Tumors sized ≥2 cm and located adjacent to the colon appear to be independent risk factors for early massive recurrence.
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Directory of Open Access Journals (Sweden)
Becciolini A
2017-06-01
Full Text Available Andrea Becciolini,1 Maria Gabriella Raimondo,2 Chiara Crotti,2 Elena Agape,2 Martina Biggioggero,2 Ennio Giulio Favalli1 1Department of Rheumatology, 2Department of Clinical Sciences and Health Community, University of Milan, Division of Rheumatology, Gaetano Pini Institute, Milan, Italy Abstract: The introduction of biological agents drastically changed the treatment paradigm of inflammatory arthritides, ameliorating the natural history of the diseases but concomitantly increasing the drug costs due to the manufacturing process. On this concern, biosimilar drugs may represent a valid option for reducing this elevated cost and increasing the availability of these highly effective treatments. Recently, CT-P13, the first biosimilar of infliximab, has been approved with the same indications established for the reference product (RP, and its daily use is progressively increasing. However, the experience with biosimilar drugs in the field of rheumatology is still limited, raising potential doubts and concerns on their correct management in real-life settings. Comparability analysis between CT-P13 and its RP was evaluated in equivalence randomized controlled trials (RCTs – PLANETRA and PLANETAS – performed on patients with rheumatoid arthritis and axial spondylitis, respectively. CT-P13 and RP showed similar profile in terms of quality, biological activity, safety, immunogenicity, and efficacy. However, the interchangeability between infliximab RP and its biosimilar still represents the most challenging issue because of a lack of a long-lasting experience. To date, reassuring preliminary data on this topic were reported in open-label extensions of PLANETRA and PLANETAS RCTs and in ongoing real-life observational studies. These findings, taken all together, significantly affect the landscape of biosimilar regulatory pathways and strongly support CT-P13 introduction as a great opportunity for expanding the accessibility to these very effective and
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Debating as an educational method to science and citizenship
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Sara Calcagnini
2007-09-01
Full Text Available If one of aims of science today is to respond to the real needs of society, it must find a new way to communicate with people and to be acquainted with their opinions and knowledge. Many science museums in Europe are adopting new ways to actively engage the public in the debate on topical scientific issues. The Museum of Science and Technology "Leonardo da Vinci" in Milan (partner of the SEDEC project has thus experimented some formats for dialogue with teachers and with the public in general. Our experience shows that museums can be places where science and the public on the one hand and democracy on the other meet.
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Stergiou, George S; Palatini, Paolo; Asmar, Roland; Bilo, Grzegorz; de la Sierra, Alejandro; Head, Geoff; Kario, Kazuomi; Mihailidou, Anastasia; Wang, Jiguang; Mancia, Giuseppe; O'Brien, Eoin; Parati, Gianfranco
2018-02-01
The European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring and Cardiovascular Variability organized a Teaching Course on 'Blood Pressure Monitoring: Theory and Practice' during the 2017 ESH Meeting in Milan, Italy. This course performed by 11 international BP monitoring experts covered key topics of BP monitoring, including office BP measurement, ambulatory BP monitoring, home BP monitoring, ambulatory versus home BP, white-coat and masked hypertension, cuff use, and BP variability. This article presents a summary of the proceedings of the ESH BP Monitoring Teaching Course, including essential information, practical issues, and recommendations on the clinical application of BP monitoring methods, aiming to the optimal management of patients with suspected or diagnosed hypertension.
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Gastric carcinoma in the dog: a clinicopathological study of 11 cases
International Nuclear Information System (INIS)
Fonda, D.; Gualtieri, M.; Scanziani, E.
1989-01-01
From October 1984 to May 1987, advanced gastric carcinoma was diagnosed in 11 dogs at the University of Milan. All cases were examined clinically, radiologically and endoscopically, and nine dogs were submitted for autopsy. The tumour mass was excised surgically in one case and treated by photodynamic therapy (haematoporphyrins and laser) in one other case. Fiberoptic examination allowed diagnosis in all the subjects. In seven of eight cases, histological diagnosis was achieved by means of transendoscopic biopsy. There appeared to be a breed predisposition to the tumour as eight of 11 tumours affected Belgian shepherd dogs and all these had neoplasms arising from the lesser curvature with prevailing histological features of mucin secreting tumours
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Aortic Valve Replacement With the Stentless Freedom SOLO Bioprosthesis: A Systematic Review.
Wollersheim, Laurens W; Li, Wilson W; Bouma, Berto J; Repossini, Alberto; van der Meulen, Jan; de Mol, Bas A
2015-10-01
This systematic review examined the clinical and hemodynamic performance of the stentless Freedom SOLO (Sorin Group, Milan, Italy) aortic bioprosthesis. The occurrence of postoperative thrombocytopenia was also analyzed. The Freedom SOLO is safe to use in everyday practice, with short cross-clamp times, and postoperative pacemaker implantation is notably lower. Valvular gradients are low and remain stable during short-term follow-up. Thrombocytopenia is more severe than in other aortic prostheses; however, this is without clinical consequences. Within a few years, the 15-year follow-up of this bioprosthesis will be known, which will be key to evaluating its long-term durability. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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Deep brain stimulation as a functional scalpel.
Broggi, G; Franzini, A; Tringali, G; Ferroli, P; Marras, C; Romito, L; Maccagnano, E
2006-01-01
Since 1995, at the Istituto Nazionale Neurologico "Carlo Besta" in Milan (INNCB,) 401 deep brain electrodes were implanted to treat several drug-resistant neurological syndromes (Fig. 1). More than 200 patients are still available for follow-up and therapeutical considerations. In this paper our experience is reviewed and pioneered fields are highlighted. The reported series of patients extends the use of deep brain stimulation beyond the field of Parkinson's disease to new fields such as cluster headache, disruptive behaviour, SUNCt, epilepsy and tardive dystonia. The low complication rate, the reversibility of the procedure and the available image guided surgery tools will further increase the therapeutic applications of DBS. New therapeutical applications are expected for this functional scalpel.
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Project for a renewable energy research centre
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Andrea Giachetta
2011-04-01
Full Text Available In Liguria, where sustainable approaches to the design, construction and management of buildings enjoy scant currency, the idea of a company from Milan (FERA s.r.l. setting up a research centre for studies into renewable energy resources, could well open up very interesting development opportunities.The project includes: environmental rehabilitation (restoration projects; strategies for the protection of water resources and waste management systems; passive and active solar systems (solar thermal and experiments with thermodynamic solar energy; hyperinsulation systems, passive cooling of buildings; use of natural materials; bio-climatic use of vegetation. The author describes the project content within the context of the multidisciplinary work that has gone into it.
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The impact of the economic crisis on Italian young people’s everyday life
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Ariela Mortara
2015-12-01
Full Text Available In Italy, the economic crisis of the last years has been characterized by recession, deflation, and unemployment. In addition to its broader effect on society, the crisis has deeply affected Italians’!everyday practices, their views, and their future goals. This is particularly true for young people, who can no longer rely on rising expectations. The paper presents the preliminary results of a qualitative study aimed at understanding how young people perceive and handle their everyday life in a social and working context so heavily influenced by income uncertainty, job insecurity, and a general lack of confidence in the future. Face-to-face in-depth interviews have been conducted in the metropolitan area of Milan (Italy.
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Clustering and Support Vector Regression for Water Demand Forecasting and Anomaly Detection
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Antonio Candelieri
2017-03-01
Full Text Available This paper presents a completely data-driven and machine-learning-based approach, in two stages, to first characterize and then forecast hourly water demand in the short term with applications of two different data sources: urban water demand (SCADA data and individual customer water consumption (AMR data. In the first case, reliable forecasting can be used to optimize operations, particularly the pumping schedule, in order to reduce energy-related costs, while in the second case, the comparison between forecast and actual values may support the online detection of anomalies, such as smart meter faults, fraud or possible cyber-physical attacks. Results are presented for a real case: the water distribution network in Milan.
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Public opinion about nuclear energy. Year 2005 poll
International Nuclear Information System (INIS)
Istenic, R.; Jencic, I.
2005-01-01
Public information is one of the important permanent activities of the Nuclear Training Centre Milan Copic at Jozef Stefan Institute in Ljubljana. It is focused on youngsters and about one half of every generation of schoolchildren in Slovenia is informed on nuclear energy. Every year since 1993 we poll youngsters using the same basic set of questions. For comparison we also polled professionals (our colleagues at the Jozef Stefan Institute) using the same questionnaire. Opinion of youngsters about nuclear energy in Slovenia can be considered favourable now (71 %), but the trend is negative. The support is dropping from initial 83% for two consecutive years. Opposition to NPP Krsko operation remains low. (author)
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Double system wave energy converter for the breaker zone
International Nuclear Information System (INIS)
Malavasi, Stefano; Negri; Marco
2015-01-01
In this paper a particular type of wave energy converter, namely EDS (Energy Double System) is presented. It is a two-body point absorber composed by a heaving float and a surging paddle, mounted on the same structure and aligned along the wave propagation direction. The system is designed for working in the breaker zone, where waves close to breaking can generate a considerable surging force on the paddle. A scale EDS model has been built and tested in the wave flume of the Hydraulics Laboratory of the 'Politecnico' of Milan. The power absorbed by the system, varying its configuration, position and wave, has been measured, and interesting efficiencies have been found.
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Roberto Ruffilli: 25 Years after his Murder. Forlì 26th April 2013
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Roberto Balzani
2013-07-01
Full Text Available In this article Roberto Balzani, the mayor of Forlì, remembers Roberto Ruffilli, 25 years after his murder. The remembrance reconstructs the steps of his academic career and of his political commitment. Ruffilli graduated at the Catholic University of Milan; his researches in contemporary history placed him in an original position if compared with the Italian studies of the time. The constant attention towards the history of administration and the transformations of the state is the basis on which Ruffilli built his proposals concerning the reform of the insitutional and political system. Balzani concludes the article by affirming that the problems of today aren't any different, that is why Ruffilli's proposals still demonstrate their modernity.
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Carpentiero, L; Costa, G; De Luca, G; Piovanelli, S; Venè, D; Righini, S; Marini, M; Baldanzi, S; Selvi, A; Scalas, S; Cassitto, M G; Sartori, S; Lacangellera, D; Bosco, A
2009-01-01
The research on stress, mobbing, and substance dependence in workers employed in the building of the great infrastructures is part of the project Euridice-Ten. The 75% of the workers employed took part in the research through an anonymous and structured questionnaire. The Clinica del Lavoro of the University of Milan elaborated the data. They point out a high risk of stress, a low level of control, a marked risk of mobbing, a high chronic fatigue in the most exhausting jobs, sleep disorders, problems in the social life as well as at home, in nourishment and at work. Many workers drink too much alcohol and the 9% of the workers know workers who use cocaine.
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Directory of Open Access Journals (Sweden)
Neven Vrček
2012-12-01
Full Text Available József Tar Institute of Intelligent Engineering Systems, BudapestGašper Mušič University of Ljubljana, SloveniaWilliam Steingartner Technical University of Košice, SlovakiaIvana Jugović Institute for Social Research, CroatiaGilda Pecaric University of Zagreb, CroatiaElisabeth Pergler Evolaris next level GmbH, AustriaAlen Lovrenčić University of Zagreb, CroatiaPeter Andreae Victoria University, New ZealandJan Paralic Technical University Kosice, SlovakiaDiana Šimić University of Zagreb, CroatiaNadica Hrgarek MED-EL Medical Electronics, AustriaJadranka Stojanovski Rudjer Boskovic Institute, CroatiaMilan Ambroz Human Resources Professional, SloveniaKatarina Žager University of Zagreb, CroatiaKresimir Fertalj University of Zagreb, Croatia
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Design and Scale Isses in the New Metropolitan City: a study of the south-east homogeneous zone
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Elena Mussinelli
2015-11-01
Full Text Available The establishment of the new Metropolitan City and recent anti-sprawl legislations form part of a new urban regeneration initiative. In this context, the goal of the current research is to provide spatial forecasts, guidelines for governance, and economic feasibility scenarios for revitalisation work. The research is centred on the Milan Metropolitan area. In addition to exploring certain theories of regeneration and resilience, this paper reinstates the practice of spatial analysis of abandoned industrial areas at a metropolitan scale and identifies boundaries, environments, and issues for meta-design testing based on public initiatives aimed at increasing socio-economic resilience for the south-east sector of the Milanese metropolitan area.
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International Nuclear Information System (INIS)
Martin, Valerie; Seguin-Jacques, Catherine; Tappero, Denis
2015-07-01
With six months to go before the Paris climate summit, the MEDCOP21 forum has brought together various players from the Mediterranean civil society in Marseille to discuss current initiatives in place to tackle climate change. ADEME actively contributed to the event. Like other economic sectors, agriculture must rethink its practices in order to contribute effectively to the energy and ecological transitions. Taking an active part in this process, ADEME has been supporting various key players of France's agricultural sector. ADEME team headed to Milan, home of the 2015 Universal Exhibition, during European Sustainable Development Week (ESDW) from 30 May to 5 June, to share its expertise on environmental evaluation of agricultural practices
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Data on occurrence and fate of emerging contaminants in a urbanised area
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Sara Castiglioni
2018-04-01
Full Text Available These data and analyses support the research article “Mass balance of emerging contaminants in the water cycle of an highly urbanized and industrialized area of Italy” by Castiglioni et al. (2018 [1].The occurrence of 80 emerging contaminats in waste and surface water was investigated in an highly urbanised area of Italy, the River Lambro basin. The data presented here include: (1 concentrations in untreated and treated wastewater of different wastewater treatment plants (WWTPs; (2 concentrations in surface water collected along the river Lambro, in the north and south of the city of Milan (main urban center in the area. These concentrations indicate the distribution and fate of emerging contaminats in the environment.
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Cricket Club
2013-01-01
The CERN Cricket Club has played 18 matches so far this season, winning 12 and losing 6, with 12 fixtures remaining before the end of the season. As match reports are too long to be included in the weekly bulletin, the full reports and the schedule, which includes a weekend trip to Milan at the end of September, can be found under “Matches (Fixtures, results, reports)” on the Cricket Club web site at http://cern.ch/Club-Cricket/ Anyone interested in playing cricket is welcome to join us at net practice, which takes place on the Prévessin site each Thursday evening from 18:00 to around 19:30 (weather permitting).
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Revisiting the Performance of MACD and RSI Oscillators
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Terence Tai-Leung Chong
2014-02-01
Full Text Available Chong and Ng (2008 find that the Moving Average Convergence–Divergence (MACD and Relative Strength Index (RSI rules can generate excess return in the London Stock Exchange. This paper revisits the performance of the two trading rules in the stock markets of five other OECD countries. It is found that the MACD(12,26,0 and RSI(21,50 rules consistently generate significant abnormal returns in the Milan Comit General and the S&P/TSX Composite Index. In addition, the RSI(14,30/70 rule is also profitable in the Dow Jones Industrials Index. The results shed some light on investors’ belief in these two technical indicators in different developed markets.
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Expo Milano 2015: The Institutionalization of Working for Free in Italy
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Roberto Ciccarelli
2015-09-01
Full Text Available This essay reports on the temporary and unpaid forms of labour around which the 2015 World’s Fair (Expo 2015 in Milan is organized and upon which it depends. The collective agreement supporting Expo 2015 is especially significant, the paper contends, in that it has been seized upon by the government of Matteo Renzi as a blueprint for the future of labour relations in Italy. Expo 2015 ushers in the institutionalization of unpaid work in the crisis-stricken Italian economy—a transformation approved by the major Italian trade unions that signed off on the collective agreement, but forcefully opposed by social movements who have decried the expansion of unpaid work permitted by the contract.
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Tamura, Sumihito; Sugawara, Yasuhiko; Kokudo, Norihiro
2014-04-27
In Asia, evidence-based guidelines for the management of hepatocellular carcinoma (HCC) have evolved, including the option of liver transplantation. Because of the continuing serious organ shortage, however, living donor liver transplantation (LDLT) remains the mainstream in Japan. Unlike deceased donor transplantation, living donor transplantation is not always limited by the restrictions imposed by the nationwide organ allocation system. The decision for transplantation may depend on institutional or case-by-case considerations, balancing the will of the donor, the operative risk, and the overall survival benefit. Cumulative data from the Japanese national multicenter registry analysis as well as individual center experiences suggest further expanding the criteria for LDLT for HCC from the Milan criteria is feasible with acceptable outcomes.
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Directory of Open Access Journals (Sweden)
Luca Poncellini
2010-06-01
Full Text Available The analysis of natural phenomena applied to architectural planning and design is facing the most fascinating and elusive of the four dimensions through which man attempts to define life within the universe: time. We all know what time is, said St. Augustine, but nobody knows how to describe it. Within architectural projects and representations, time rarely appears in explicit form. This paper presents the results of a research conducted by students of NABA and of the Polytechnic of Milan with the purpose of representing time considered as a key element within architectural projects. Student investigated new approaches and methodologies to represent time using the two-dimensional support of a sheet of paper.
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Analysis of the communities of an urban mobile phone network.
Botta, Federico; Del Genio, Charo I
2017-01-01
Being able to characterise the patterns of communications between individuals across different time scales is of great importance in understanding people's social interactions. Here, we present a detailed analysis of the community structure of the network of mobile phone calls in the metropolitan area of Milan revealing temporal patterns of communications between people. We show that circadian and weekly patterns can be found in the evolution of communities, presenting evidence that these cycles arise not only at the individual level but also at that of social groups. Our findings suggest that these trends are present across a range of time scales, from hours to days and weeks, and can be used to detect socially relevant events.
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Food quality, effects on health and sustainability today: a model case report.
Borroni, Vittorio Natale; Fargion, Silvia; Mazzocchi, Alessandra; Giachetti, Marco; Lanzarini, Achille; Dall'Asta, Margherita; Scazzina, Francesca; Agostoni, Carlo
2017-02-01
The Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico is a five-century institution that, besides the unique clinical role in the center of Milan, may rely on benefactor donations such as fields and farming houses not far from the city, for a total of 8500 ha, all managed by the "Sviluppo Ca' Granda' Foundation". Presently, the main products of these fields are represented by rice and cow's milk. During the latest years, farmers and managers have developed a model of sustainable food production, with great attention to the product quality based on compositional analysis and functional nutritional characteristics. This experience represents a new holistic model of food production and consumption, taking great care of both sustainability and health.
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Directory of Open Access Journals (Sweden)
Restelli U
2014-09-01
Full Text Available Umberto Restelli,1,2 Massimo Andreoni,3 Andrea Antinori,4 Marzia Bonfanti,2 Giovanni Di Perri,5 Massimo Galli,6 Adriano Lazzarin,7 Giuliano Rizzardini,8,9 Davide Croce1,2 1Department of Community Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 2Centro di Ricerca in Economia e Management in Sanità e nel Sociale (CREMS, Università Carlo Cattaneo – LIUC, Castellanza (VA, Italy; 3Clinical Infectious Diseases, Tor Vergata University (PTV, Rome, Italy; 4Clinical Department, National Institute for Infectious Diseases "L. Spallanzani," Rome, Italy; 5Department of Medical Sciences, Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy; 6Third Division of Infectious Diseases, "Luigi Sacco" Hospital, Milan, Italy; 7Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy; 8First and Second Divisions of Infectious Diseases, "Luigi Sacco" Hospital, Milan, Italy; 9School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Background: Deintensification and less drug regimen (LDR antiretroviral therapy (ART strategies have proved to be effective in terms of maintaining viral suppression in human immunodeficiency virus (HIV-positive patients, increasing tolerability, and reducing toxicity of antiretroviral drugs administered to patients. However, the economic impact of these strategies have not been widely investigated. The aim of the study is to evaluate the economic impact that ART LDR could have on the Italian National Health Service (INHS budget. Methods: A budget impact model was structured to assess the potential savings for the INHS by the use of ART LDR for HIV-positive patients with a 3 year perspective. Data concerning ART cost, patient distribution within different ARTs, and probabilities for patients to change ART on a yearly basis were collected within four Italian infectious diseases departments, providing
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Exploiting CReP for Knowledge Retrieval and Use in Complex Domains
Manenti, Lorenza; Sartori, Fabio
Case Based Reasoning (CBR) is a Knowledge Management approach that consists in the development of decision support systems where problem are solved by analogy with similar problem solved in the past. In this way, the system supports users in finding solutions without starting from scratch. CBR has become a very important research topic in Artificial Intelligence, with the definition of methodologies and architectural patterns for supporting developers in the design and implementation of case-based systems. The paper presents one of this frameworks, namely CReP, an on-going research project of the Artificial Intelligence Laboratory (L.Int.Ar.) of University of Milan-Bicocca, focusing on the integration between CBR paradigm and metadata approach to obtain domain-independent case structure and retrieval algorithm definition.
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A Trust-Based Pact in Research Biobanks. From Theory to Practice.
Sanchini, Virginia; Bonizzi, Giuseppina; Disalvatore, Davide; Monturano, Massimo; Pece, Salvatore; Viale, Giuseppe; Di Fiore, Pier Paolo; Boniolo, Giovanni
2016-05-01
Traditional Informed Consent is becoming increasingly inadequate, especially in the context of research biobanks. How much information is needed by patients for their consent to be truly informed? How does the quality of the information they receive match up to the quality of the information they ought to receive? How can information be conveyed fairly about future, non-predictable lines of research? To circumvent these difficulties, some scholars have proposed that current consent guidelines should be reassessed, with trust being used as a guiding principle instead of information. Here, we analyse one of these proposals, based on a Participation Pact, which is already being offered to patients at the Istituto Europeo di Oncologia, a comprehensive cancer hospital in Milan, Italy. © 2015 John Wiley & Sons Ltd.
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Glioblastoma multiforme of the cerebellum: description of three cases.
Luccarelli, G
1980-01-01
Only 43 cases of glioblastoma multiforme of the cerebellum have been reported in the literature. This report is based on the findings of 3 cerebellar glioblastomas in a review of 1,206 consecutive confirmed cases of glioblastoma operated on between 1947 and 1977 at the Istituto Neurologico of Milan, giving an incidence of 0.24%. Clinical features are similar to those of any other fast-growing subtentorial tumour. Neuroradiological studies, including CAT, are of little help in predicting the exact nature of these tumours before surgery. A correct diagnosis can be reached only by microscopic examination. Histological patterns appear in no way to differ from those of cerebral glioblastoma. The biological behaviour of these tumours is in all respects identical to that of glioblastoma of cerebral hemispheres.
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Trends in discovery of new drugs for tuberculosis therapy.
Riccardi, Giovanna; Pasca, Maria Rosalia
2014-09-01
After the introduction of isoniazid and rifampicin, the second one discovered in the Lepetit Research Laboratories (Milan, Italy), under the supervision of Professor Piero Sensi, tuberculosis (TB) was considered an illness of the past. Unfortunately, this infectious disease is still a global health fear, due to the multidrug-resistant Mycobacterium tuberculosis and extensively circulating drug-resistant strains, as well as the unrecognized TB transmission, especially in regions with high HIV incidence. In the last few years, new antitubercular molecules appeared on the horizon both in preclinical and clinical stage of evaluation. In this review, we focus on a few of them and on their mechanism of action. Two new promising drug targets, DprE1 and MmpL3, are also discussed.
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Microbiological Analysis of Surfaces of Leonardo Da Vinci's Atlantic Codex: Biodeterioration Risk.
Tarsitani, Gianfranco; Moroni, Catia; Cappitelli, Francesca; Pasquariello, Giovanna; Maggi, Oriana
2014-01-01
Following the discovery of discoloration on some pages of the Atlantic Codex (AC) of Leonardo da Vinci kept in the Biblioteca Ambrosiana in Milan, some investigations have been carried out to verify the presence of microorganisms, such as bacteria and fungi. To verify the presence of microorganisms a noninvasive method of sampling has been used that was efficient and allowed us to highlight the microbial facies of the material that was examined using conventional microbiological techniques. The microclimatic conditions in the storage room as well as the water content of the volume were also assessed. The combined observations allowed the conclusion that the discoloration of suspected biological origin on some pages of AC is not related to the presence or current attack of microbial agents.
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A wide dynamic range BF3 neutron monitor with front-end electronics based on a logarithmic amplifier
International Nuclear Information System (INIS)
Ferrarini, M.; Varoli, V.; Favalli, A.; Caresana, M.; Pedersen, B.
2010-01-01
This paper describes a wide dynamic range neutron monitor based on a BF 3 neutron detector. The detector is used in current mode, and front-end electronics based on a logarithmic amplifier are used in order to have a measurement capability ranging over many orders of magnitude. The system has been calibrated at the Polytechnic of Milan, CESNEF, with an AmBe neutron source, and has been tested in a pulsed field at the PUNITA facility at JRC, Ispra. The detector has achieved a dynamic range of over 6 orders of magnitude, being able to measure single neutron pulses and showing saturation-free response for a reaction rate up to 10 6 s -1 . It has also proved effective in measuring the PUNITA facility pulse integral fluence.
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La Società Umanitaria e la diffusione del Metodo Montessori (1908-1923
Directory of Open Access Journals (Sweden)
Irene Pozzi
2015-07-01
Full Text Available The Società Umanitaria ofMilan, between 1918 and 1923, played an essential role in spreading and developing the Montessori Method. Studying in the Historical Archive of Società Umanitaria the numerous documents there collected, the author reconstructed the crucial moments of the extremely significant collaboration between Maria Montessori and Augusto Osimo, General Secretary of the Società Umanitaria.This complex and in-depth investigation was guided by the analysis, in specific, of the training courses for Montessori teachers organised by Società Umanitaria, essentially unexamined before this study, that allowed the researcher to have a deep insight into the action of Società Umanitaria aimed to promote and implement the Montessori Method in Italy and all around the world.
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Directory of Open Access Journals (Sweden)
Éric Saunier
2011-01-01
Full Text Available For a long period of time, the slow modernization of social history characterized the masonic historiography and the Napolean period. This paper was presented on the bicentenary of the Grand Orient of Italy in Milan in May 200 and it aims to show the need to target a different perspective on this period. In this regard, several recent studies on this topic show that far from the canonical view, the study of the practices of the Masonic lodges initiated between 1804 and 1815 gave birth to new types of diverse social and political behavior, showing in fact that the Napoleonic period should rather be seen as a time when Masonic national identities were established rather than as a period of manipulation.
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A high-performance network for a distributed-control system
International Nuclear Information System (INIS)
Cuttone, G.; Aghion, F.; Giove, D.
1989-01-01
Local area networks play a central rule in modern distributed-control systems for accelerators. For a superconducting cyclotron under construction at the University of Milan, an optical Ethernet network has been implemented for the interconnection of multicomputer-based stations. Controller boards, with VLSI protocol chips, have been used. The higher levels of the ISO OSI model have been implemented to suit real-time control requirements. The experimental setup for measuring the data throughput between stations will be described. The effect of memory-to-memory data transfer with respect to the packet size has been studied for packets ranging from 200 bytes to 10 Kbytes. Results, showing the data throughput to range from 0.2 to 1.1 Mbit/s, will be discussed. (orig.)
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International Nuclear Information System (INIS)
Bonizzoni, L.; Poldi, G.; Milazzo, M.; Galli, A.
2007-01-01
In this paper, we report a few examples showing how energy dispersive XRF analysis (EDXRF) coupled with visible reflectance spectroscopy (vis-RS) can be successfully applied for the investigation of wood or canvas paintings by performing stratigraphic analyses with non-invasive techniques. The specific aim is to reconstruct layers and their thicknesses. The method has been tested in the laboratory on paint layers similar to traditional Renaissance ones. In situ analyses of a famous wood painting by Andrea Mantegna - 'Madonna col bambino e un coro di cherubini', Pinacoteca di Brera, Milan - were also carried out. While illustrating the results concerning the identification of pigments and the discrimination of layer stratigraphy, advantages and limitation of this method are pointed out. (authors)
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Directory of Open Access Journals (Sweden)
Milan Jesih
1996-12-01
Full Text Available Poeta, dramaturgo y traductor Milan Jesih nació el 14 de abril de 1950. Estudió Literatura comparada en Ljubljana. Ha sido miembro del grupo vanguardista 442. Vive en Ljubljana. Su primer libro de poesía se publica en el año 1972 bajo el título Uran v urinu, gospodar! (iUranio en la orina, señor!. A este le siguen: Legende (1974, Leyendas, Kobalt (1976, Cobalto, Volfram (1980, Volframio, Usta (1985, Boca, Soneti (1989, Sonetos, Soneti drugi (1993, Sonetos segundos. Su poesía se basa en los juegos de palabras, sonoridad enfatizada, ironía, sátira y parodia, sus últimos libros de poesía estan dedicados al soneto
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Typological surveys on the historic city. Actuality of Townhouse
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Michele Caja
2016-11-01
Full Text Available After the rediscovery of the historical city by the Italian urban analysis of the fifties and sixties and the following European urban projects of critical reconstruction, it arises a new awareness of the historical city as an artifact built over time and the possibility of its continuity. This recovered temporal condition of consolidated contexts defines the margin within which it is defined the architectural design of urban living, here exemplified through some didactic experiments carried out in two cities (Berlin and Milan. Among the ways of interventions, almost in a surgical manner, emerges on often-unresolved urban sites the thematic confrontation with the urban block and the townhouse, intended as the minimum element of the architecture of the city.
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Spain's marketing sector seeing more changes
International Nuclear Information System (INIS)
Anon.
1992-01-01
This paper reports that Spain's petroleum marketing sector continues to restructure. Partly state owned Repsol SA and Royal Dutch/Shell Group are discussing supplying each other's retail outlets in the UK and Spain. And Portugal's state owned Petroleos de Portugal (Petrogal), seeking to sharply expand retail operations in Spain, complains of government interference with foreign investment in Spanish marketing. Meantime, Conoco Inc. Has agreed with Saras SpA Raffinerie Sarde, Milan, to set up a network of service stations in northern Spain and Portugal at a cost of 100 billion pesetas (%972 million). The two are considering building an oil terminal at the port city of Gijon in Asturias, Spain, and the Exxon Corp., Total, and Shell are interested in participating in the project
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5th International Workshop on Complex Networks and their Applications
Gaito, Sabrina; Quattrociocchi, Walter; Sala, Alessandra
2017-01-01
This book highlights cutting-edge research in the field of network science, offering scientists, researchers and graduate students a unique opportunity to catch up on the latest advances in theory and a multitude of applications. It presents the peer-reviewed proceedings of the fifth International Workshop on Complex Networks & their Applications (COMPLEX NETWORKS 2016), which took place in Milan during the last week of November 2016. The carefully selected papers are divided into 11 sections reflecting the diversity and richness of research areas in the field. More specifically, the following topics are covered: Network models; Network measures; Community structure; Network dynamics; Diffusion, epidemics and spreading processes; Resilience and control; Network visualization; Social and political networks; Networks in finance and economics; Biological and ecological networks; and Network analysis.
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Update on the management of severe hypertriglyceridemia – focus on free fatty acid forms of omega-3
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Pirillo A
2015-04-01
Full Text Available Angela Pirillo,1,2 Alberico Luigi Catapano2,3 1Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy; 2IRCCS Multimedica, Milan, Italy; 3Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy Abstract: High levels of plasma triglycerides (TG are a risk factor for cardiovascular diseases, often associated with anomalies in other lipids or lipoproteins. Hypertriglyceridemia (HTG, particularly at very high levels, significantly increases also the risk of acute pancreatitis. Thus, interventions to lower TG levels are required to reduce the risk of pancreatitis and cardiovascular disease. Several strategies may be adopted for TG reduction, including lifestyle changes and pharmacological interventions. Among the available drugs, the most commonly used for HTG are fibrates, nicotinic acid, and omega-3 polyunsaturated fatty acids (usually a mixture of eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. These last are available under different concentrated formulations containing high amounts of omega-3 fatty acids, including a mixture of EPA and DHA or pure EPA. The most recent formulation contains a free fatty acid (FFA form of EPA and DHA, and exhibits a significantly higher bioavailability compared with the ethyl ester forms contained in the other formulations. This is due to the fact that the ethyl ester forms, to be absorbed, need to be hydrolyzed by the pancreatic enzymes that are secreted in response to fat intake, while the FFA do not. This higher bioavailability translates into a higher TG-lowering efficacy compared with the ethyl ester forms at equivalent doses. Omega-3 FFA are effective in reducing TG levels and other lipids in hypertriglyceridemic patients as well as in high cardiovascular risk patients treated with statins and residual HTG. Currently, omega-3 FFA formulation is under evaluation to establish whether, in high cardiovascular risk
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Castiglioni, Sara; Davoli, Enrico; Riva, Francesco; Palmiotto, Marinella; Camporini, Paolo; Manenti, Angela; Zuccato, Ettore
2017-12-22
The occurrence of several classes of emerging contaminants (ECs) was assessed in the River Lambro basin, one of the most urbanized and industrialized areas of Italy. The study aims were to identify the main sources of ECs, quantify their amounts circulating in the water cycle, and study their fate in the aquatic environment. More than 80 ECs were selected among pharmaceuticals (PHARM), personal care products (PCPs), disinfectants (DIS), illicit drugs (IDs), perfluorinated compounds (PERF), alkylphenols and bisphenol A (Alk-BPA), and anthropogenic markers (AM). Specific analytical methods were developed for quantitative analysis based on solid phase extraction and liquid chromatography tandem mass spectrometry. ECs were measured in rivers upstream and downstream of the main city (Milan), and in untreated and treated wastewater from Milan to assess the contribution to river contamination, and in superficial and deep groundwater in the city area to study the relationship between river and groundwater contamination. Samples were collected in a two-year monitoring campaign. Almost all ECs were ubiquitous in untreated wastewater, at concentrations up to the μg/L range, and the most abundant classes were PHARM and AM. Removals during different wastewater treatment processes were studied and the most stable substances were PHARM, PCPs and PERF. The mass loads increased for all the classes of ECs along the River Lambro basin. A mass balance was done in the river basin and allowed to identify the main sources of contamination, which were domestic, from treated or untreated wastewater, for PHARM, PCPs and IDs, mainly industrial for PERF, and both industrial and domestic for Alk-BPA. The study of AM helped to identify direct discharges of untreated wastewater. A substantial contribution of surface water to groundwater contamination was observed. This study improves the knowledge on occurrence, sources and fate of multiple classes of ECs in a highly urbanized area providing
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Yoo EJ
2013-06-01
Full Text Available Eun Jin Yoo,1,* Hye Sun Shin,1,* Seung Up Kim,1,2,7 Dong Jin Joo,3,4 Jun Yong Park,1,2,7 Gi Hong Choi,3 Do Young Kim,1,2,7 Sang Hoon Ahn,1,2,7 Jinsil Seong,5 Myung Joo Koh,6 Kwang-Hyub Han,1,2,7 Chae Yoon Chon1,2,7 1Department of Internal Medicine, 2Institute of Gastroenterology, 3Department of Surgery, 4Research Institute for Transplantation, 5Department of Radiation Oncology, 6Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea; 7Liver Cirrhosis Clinical Research Center, Seoul, South Korea *These authors contributed equally to this work Abstract: We herein report a patient with advanced hepatitis B virus-related hepatocellular carcinoma (HCC beyond the Milan criteria. He underwent orthotopic liver transplantation after successful HCC downstaging that satisfied the University of California, San Francisco criteria, using concurrent chemoradiation therapy with a combination of repeated hepatic arterial infusion chemotherapy (HAIC and sorafenib. A 52-year-old male was diagnosed with advanced hepatitis B virus-related HCC beyond the Milan criteria. He underwent concurrent chemoradiation therapy (50 Gy with 20 fractions over 5 weeks with HAIC using 5-fluorouracil at a dose of 500 mg/day, which was administered during the first and fifth weeks of radiation therapy as an initial treatment modality. This was followed by the combined use of HAIC using 5-fluorouracil (500 mg/m2 for 5 hours on days 1–3 and cisplatin (60 mg/m2 for 2 hours on day 2 every 4 weeks (twelve cycles and sorafenib (from the third to the twelfth cycle of HAIC to treat the remaining HCC. Because a remarkable decrease in the tumor burden that satisfied the University of California, San Francisco criteria was observed after these combination treatments, the patient underwent orthotopic liver transplantation with curative aim and survived for 11 months without evidence of HCC recurrence. Keywords: hepatocellular carcinoma, liver transplantation
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Tarlarini C
2012-08-01
Full Text Available Claudia Tarlarini,1 Silvana Penco,1 Massimo Conio,2 Enzo Grossi3 On behalf of the Barrett Italian Study Group 1Department of Laboratory Medicine, Medical Genetics, Niguarda Ca’ Granda Hospital, Milan, Italy; 2Department of Gastroenterology, General Hospital, San Remo, Italy; 3Medical Department, Bracco Imaging SpA, Milan, ItalyBackground: Barrett’s esophagus (BE, a metaplastic premalignant disorder, represents the primary risk factor for the development of esophageal adenocarcinoma. Chronic gastroesophageal reflux disease and central obesity have been associated with BE and esophageal adenocarcinoma, but relatively little is known about the specific genes that confer susceptibility to BE carcinogenesis.Methods: A total of 74 patients with BE and 67 controls coming from six gastrointestinal Italian units were evaluated for six polymorphisms in four genes: XPC, XPD nucleotide excision repair (NER genes, XRCC1 (BER gene, and glutathione S-transferase P1. Smoking status was analyzed together with the genetic data. Statistical analysis was performed through Artificial Neural Networks.Results: Distributions of sex, smoking history, and polymorphisms among BE cases and controls did not show statistically significant differences. The r-value from linear correlation allowed us to identify possible protective factors as well as possible risk factors. The application of advanced intelligent systems allowed for the selection of a subgroup of nine variables. Artificial Neural Networks applied on the final data set reached mean global accuracy of 60%, reaching as high as 65.88%.Conclusion: We report here results from an exploratory study. Results from this study failed to find an association among the tested single nucleotide polymorphisms and BE phenotype through classical statistical methods. On the contrary, advanced intelligent systems are really able to handle the disease complexity, not treating the data with reductionist approaches unable to detect
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Sacchi M
2014-07-01
Full Text Available Matteo Sacchi, Edoardo Villani, Francesca Gilardoni, Paolo Nucci University Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy Background: Macular edema is a known complication even after uneventful cataract surgery. The chronic use of prostaglandin analogs is a risk factor for the development of pseudophakic cystoid macular edema (CME. Nonsteroidal anti-inflammatory drugs (NSAIDs are considered first-line therapy but refractory postsurgical CME represents a therapeutic challenge, as there is not an evidence-based treatment.Objective: To report the use of a single implant of intravitreal dexamethasone for tafluprost-associated pseudophakic CME refractory to NSAIDs and to sub-Tenon’s corticosteroid injections.Case report: A 64-year-old female with ocular hypertension treated with tafluprost experienced decreased vision (visual acuity 20/60 and metamorphopsia 2 months after uneventful cataract extraction. Spectral domain optical coherence tomography (SD-OCT revealed CME. After 1 month of topical and oral NSAIDs, CME was still evident on SD-OCT (visual acuity 20/50. Two sub-Tenon’s betamethasone injections were performed at a 2-week interval. As CME was still present, 2 months after the diagnosis of CME (visual acuity 20/40, the patient underwent a single dexamethasone intravitreal implant. One month later, macular appearance was normal, and visual acuity increased to 20/30. This result was maintained throughout the 6 months of follow-up.Conclusion: In this report, a single implant of intravitreal dexamethasone successfully treated pseudophakic CME associated with the use of prostaglandin analogs unresponsive to NSAIDs and sub-Tenon’s betamethasone. The results of this report need to be corroborated by powered, prospective, randomized trials. The need for repeated treatments as well as the retreatment interval in patients requiring more than a single injection are issues still needing further investigations. Keywords
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Marzorati C
2017-03-01
Full Text Available Chiara Marzorati,1,2 Gabriella Pravettoni2,3 1Foundations of the Life Sciences, Bioethics and Cognitive Science, European School of Molecular Medicine (SEMM, 2Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology, 3Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy Abstract: In the last 10 years, value has played a key role in the health care system. In this concept, innovations in medical practice and the increasing importance of patient centeredness have contributed to draw the attention of the medical community. Nonetheless, a large consensus on the meaning of “value” is still lacking: patients, physicians, policy makers, and other health care professionals have different ideas on which component of value may play a prominent role. Yet, shared clinical decision-making and patient empowerment have been recognized as fundamental features of the concept of value. Different paradigms of health care system embrace different meanings of value, and the absence of common and widely accepted definition does not help to identify a unique model of care in health care system. Our aim is to provide an overview of those paradigms that have considered value as a key theoretical concept and to investigate how the presence of value can influence the medical practice. This article may contribute to draw attention toward patients and propose a possible link between health care system based on “value” and new paradigms such as patient-centered system (PCS, patient empowerment, and P5 medicine, in order to create a predictive, personalized, preventive, participatory, and psycho-cognitive model to treat patients. Indeed, patient empowerment, value-based system, and P5 medicine seem to shed light on different aspects of a PCS, and this allows a better understanding of people under care. Keywords: health care system, value, value-based medicine, patient empowerment, clinical decision
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Coronary artery disease in Africa and the Middle East
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Kurdi MI
2012-02-01
Full Text Available Wael Almahmeed1, Mohamad Samir Arnaout2, Rafik Chettaoui3, Mohsen Ibrahim4, Mohamed Ibrahim Kurdi5, Mohamed Awad Taher6, Giuseppe Mancia71Heart and Vascular Institute, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates; 2American University of Beirut Medical Center, Beirut, Lebanon; 3General and Cardiovascular Clinic of Tunis, Tunisia; 4Cairo University, Cairo, Egypt; 5King Khalid University Hospital and The Kingdom Hospital, Saudi Arabia; 6Ain Shams University School of Medicine, Cairo, Egypt; 7University of Milan, Bicocca, Milan, ItalyAbstract: Countries in Africa and the Middle East bear a heavy burden from cardiovascular disease. The prevalence of coronary heart disease is promoted in turn by a high prevalence of cardiovascular risk factors, particularly smoking, hypertension, dyslipidemia, diabetes, and sedentary lifestyles. Patients in Africa and the Middle East present with myocardial infarction at a younger age, on average, compared with patients elsewhere. The projected future burden of mortality from coronary heart disease in Africa and the Middle East is set to outstrip that observed in other geographical regions. Recent detailed nationally representative epidemiological data are lacking for many countries, and high proportions of transient expatriate workers in countries such as Saudi Arabia and the United Arab Emirates complicate the construction of such datasets. However, the development of national registries in some countries is beginning to reveal the nature of coronary heart disease. Improving lifestyles (reducing calorie intake and increasing physical activity in patients in the region will be essential, although cultural and environmental barriers will render this difficult. Appropriate prescribing of pharmacologic treatments is essential in the prevention and management of cardiovascular disease. In particular, recent controversies relating to the therapeutic profile of beta-blockers may have reduced their use. The
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Cognitive behavioral therapy to aid weight loss in obese patients: current perspectives
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Castelnuovo G
2017-06-01
Full Text Available Gianluca Castelnuovo,1,2 Giada Pietrabissa,1,2 Gian Mauro Manzoni,1,3 Roberto Cattivelli,1,2 Alessandro Rossi,1 Margherita Novelli,1 Giorgia Varallo,1 Enrico Molinari1,2 1Psychology Research Laboratory, Istituto Auxologico Italiano IRCCS, San Giuseppe Hospital, Verbania, 2Department of Psychology, Catholic University of Milan, Milan, 3Faculty of Psychology, eCampus University, Novedrate, Italy Abstract: Obesity is a chronic condition associated with risk factors for many medical complications and comorbidities such as cardiovascular diseases, some types of cancer, osteoarthritis, hypertension, dyslipidemia, hypercholesterolemia, type-2 diabetes, obstructive sleep apnea syndrome, and different psychosocial issues and psychopathological disorders. Obesity is a highly complex, multifactorial disease: genetic, biological, psychological, behavioral, familial, social, cultural, and environmental factors can influence in different ways. Evidence-based strategies to improve weight loss, maintain a healthy weight, and reduce related comorbidities typically integrate different interventions: dietetic, nutritional, physical, behavioral, psychological, and if necessary, pharmacological and surgical ones. Such treatments are implemented in a multidisciplinary context with a clinical team composed of endocrinologists, nutritionists, dietitians, physiotherapists, psychiatrists, psychologists, and sometimes surgeons. Cognitive behavioral therapy (CBT is traditionally recognized as the best established treatment for binge eating disorder and the most preferred intervention for obesity, and could be considered as the first-line treatment among psychological approaches, especially in a long-term perspective; however, it does not necessarily produce a successful weight loss. Traditional CBT for weight loss and other protocols, such as enhanced CBT, enhanced focused CBT, behavioral weight loss treatment, therapeutic education, acceptance and commitment therapy
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Nocturnal drainage wind characteristics in two converging air sheds
International Nuclear Information System (INIS)
Gedayloo, T.; Clements, W.E.; Barr, S.; Archuleta, J.A.
1980-01-01
During the short experimental period in the Grants Basin of Northeastern New Mexico a survey was conducted on the complex meteorology of this area. Emphasis was placed on the nocturnal drainage flow because of the potential hazards to the populated areas of Milan and Grants from the effluents of the uranium mining and milling operation in this area. This investigation has shown that the nocturnal drainage flow patterns agree with the winds predicted on the basis of the complex terrain of the area. Because of the surface cooling at night (over 25 0 C during summer and about 20 0 C during winter), air from elevated surrounding areas flows to the low lying regions consequently setting up a nocturnal drainage flow. This regime exists over 60% of the time during summer months and over 65% of the time during winter months with a depth generally less than 200 m. In the San Mateo air shed the drainage flow is east northeast, and in the Ambrosia Lake air shed it is from northwest. The confluence of these two air flows contributes mainly to the drainage flow through the channel formed by La Ja Mesa and Mesa Montanosa. The analysis of data collected by the recording Flats Station confirms the prediction that although the area south of the channel region broadens considerably causing a reduction in flow speed, contributions from the southside of La Jara Mesa and Mesa Montanosa partly compensate for this reduction. The position of this recording station is 15 to 20 km from the populated towns of Milan and Grants. A drainage flow speed of approximately 2.2 m s -1 and the duration of over 11 hours as recorded by this station indicates that air from the San Mateo and Ambrosia Lake regions may be transported southwards to these population centers during a nocturnal period. In order to test this prediction, a series of multi-atmospheric tracer experiments were conducted in the Grants Basin
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Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study
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Maramaldi G
2016-02-01
Full Text Available Giada Maramaldi,1 Stefano Togni,1 Ivan Pagin,1 Luca Giacomelli,2 Roberta Cattaneo,3 Roberto Eggenhöffner,2 Samuele E Burastero4 1Indena S.p.A, Milan, 2Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, 3Abich Srl, Verbania, 4San Raffaele Scientific Institute, Milan, ItalyBackground: We evaluated the ability of quercetin, a natural antioxidant formulated in a specific delivery system, to reduce skin inflammation induced by a variety of stimuli, including UV radiation, stimulation with a histamine solution, or contact with chemical irritants. In particular, we tested the soothing and anti-itch effect of Quercevita®, 1% cream for external use, a formulation characterized by a phospholipids-based delivery system.Patients and methods: The study was a monocentric, single blind trial that enrolled a group of 30 healthy volunteers. The back of each subject was examined to identify four quadrants with no previous skin damage or naevi that were treated in order to induce a controlled and reversible form of skin stress. The areas were treated as follows: no product; Quercevita® 1% cream, 2 mg/cm2; placebo; positive control (a commercially available topical formulation containing 1% dexchlorpheniramine.Results: Only quercetin phospholipids 1% and dexchlorpheniramine 1% achieved a significant reduction in erythema with comparable results: (–10.05% [P=0.00329] for quercetin phospholipids 1% vs –14.05% [P=0.00046] for the positive control. Moreover, quercetin phospholipids 1% and dexchlorpheniramine 1% were both associated with a significant decrease in mean wheal diameter: (–13.25% and –12.23% for dexchlorpheniramine 1%, respectively. Similar findings were reported for the other tested parameters.Conclusion: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able
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[Influence of implants prepared by selective laser melting on early bone healing].
Liu, J Y; Chen, F; Ge, Y J; Wei, L; Pan, S X; Feng, H L
2018-02-18
To evaluate the influence of the rough surface of dental implants prepared by selective laser melting (SLM) on early bone healing around titanium implants. A total of sixteen titanium implants were involved in our research, of which eight implants were prepared by SLM (TIXOS Cylindrical, Leader-Novaxa, Milan, Italy; 3.3 mm×10 mm, internal hex) and the other eight were sandblasted, large-grit and acid-etched (SLA) implants (IMPLUS Cylindrical, Leader-Novaxa, Milan, Italy; 3.3 mm×10 mm, internal hex). All of the dental implants were inserted into the healed extraction sockets of the mandible of two adult male Beagle dogs. Half of the dental implants were designed to be healed beneath the mucosa and the other half were intended to be healed transgingivally and were immediately loaded by acrylic resin bridge restoration. Three types of tetracycline fluorescent labels, namely calcein blue, alizarin complexone and calcein, were administered into the veins of the Beagle dogs 2, 4, and 8 weeks after implant placement respectively for fluorescent evaluation of newly formed bone peri-implant. Both Beagle dogs were euthanized 12 weeks after implant insertion and the mandible block specimens containing the titanium implants and surrounding bone and soft tissue of each dog were carefully sectioned and dissected. A total of 16 hard tissue slices were obtained and stained with toluidine blue for microscopic examination and histomorphometric measurements. Histological observation was made for each slice under light microscope and laser scanning confocal microscope (LSCM). Comparison on new bone formation around titanium implants of each group was made and mineral apposition rate (MAR) was calculated for each group. Dental implants prepared by selective laser melting had achieved satisfying osseointegration to surrounding bone tissue after the healing period of 12 weeks. Newly formed bone tissue was observed creeping on the highly porous surface of the SLM implant and growing
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A comprehensive cooperative project for children with renal diseases in Nicaragua.
Edefonti, A; Marra, G; Castellón Perez, M; Sandoval Díaz, M; Sereni, F
2010-11-01
In low-income countries renal diseases generally and chronic kidney disease (CKD) in particular represent a wide-spread and often underdiagnosed clinical problem. The aim of the cooperative project between the pediatric nephrology units of Milan, Italy, and Managua, Nicaragua was to improve the diagnosis and treatment of renal diseases and CKD in Nicaraguan children. When the project started, in 2000, there were many constraints in human and material resources in the Children's Hospital in Managua. Since 2001, a specialized Unit of Pediatric Nephrology and Urology has developed, offering free of charge basic clinical assistance to hospitalized children, and training abroad of the whole staff. Shared protocols, renovation of infrastructure and an information technology (IT) program were implemented. In 2003, renal replacement therapy (RRT) for selected children was initiated, along with a network of six department hospitals in 2005 and, in 2007, a CKD prevention program in the most peripheral Health Units, so that 61% of the Nicaraguan pediatric population is now covered by the project. To ensure implementation of the project, applications for funds to Italian private and public institutions were made and a Nicaraguan charity foundation was activated. The Nicaraguan Ministry of Health and the hospital directors were always involved in the plans of the development of the project and accepted the progressive transfer of the costs to the government, throughout the 9-year duration of the project. The IT program, inclusive of a database of children with kidney and other urinary tract (UT) diseases and a web connection between Milan and Managua, was crucial in monitoring the activities and providing epidemiological data, in order to better allocate resources. The clinical activities and the number of children managed in Managua in 2008 are similar to those of pediatric nephrology units worldwide and depict the level of clinical autonomy achieved. The sister-center model
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Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
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Raimondo MG
2017-05-01
Full Text Available Maria Gabriella Raimondo,1 Martina Biggioggero,1 Chiara Crotti,1 Andrea Becciolini,2 Ennio Giulio Favalli2 1Department of Clinical Sciences and Health Community, Division of Rheumatology, University of Milan, 2Department of Rheumatology, Gaetano Pini Institute, Milan, Italy Abstract: In recent years the use of biotechnological agents has drastically revolutionized the therapeutic approach and the progression of rheumatoid arthritis (RA. In particular, interleukin-6 (IL-6 has been demonstrated as a pivotal cytokine in the pathogenesis of the disease by contributing to both the innate and the adaptive immune system perturbation, and to the production of acute-phase proteins involved in the systemic expression of the disorder. The first marketed IL-6 blocker was tocilizumab, a humanized anti-IL-6 receptor (anti-IL-6R monoclonal antibody. The successful use of tocilizumab in RA has encouraged the development of other biologic agents specifically targeting the IL-6 pathway, either directed against IL-6 cytokine (sirukumab, olokizumab, and clazakizumab or IL-6 receptor (sarilumab. One Phase II and six Phase III randomized controlled trials demonstrated a broad efficacy of sarilumab across all RA patient subtypes, ranging from methotrexate (MTX to tumor necrosis factor inhibitor insufficient responders. In particular, sarilumab as monotherapy demonstrated a clear head-to-head superiority over adalimumab in MTX-intolerant subjects. In addition, compared with tocilizumab, sarilumab showed a similar safety profile with significantly higher affinity and longer half-life, responsible for a reduction of the frequency of administration (every other week instead weekly. All these aspects may be important in defining the strategy for positioning sarilumab in the treatment algorithm of RA. Indeed, observational data coming from post-marketing real-life studies may provide crucial additional information for better understanding the role of sarilumab in the
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Mucoceles of the oral cavity: a large case series (1994-2008) and a literature review.
Re Cecconi, Dario; Achilli, Antonio; Tarozzi, Marco; Lodi, Giovanni; Demarosi, Federica; Sardella, Andrea; Carrassi, Antonio
2010-07-01
Evaluating data of patients affected by oral mucoceles, examined at the Unit of Oral Medicine and Pathology of the University of Milan between January 1994 and December 2008. Concise review on oral mucoceles and analysis of the clinical files of patients who underwent excisional biopsy (patient age, medical history, diagnosis, date and site of the biopsy, histopathological diagnosis and recurrences if any). During the period June 1994-December 2008, 158 mucoceles were observed (93 males and 65 females), with the most frequent site being the lower lip (53%) (p=0.001 by Fisher's test). The mean age of the patients was 31.9 years, with a peak of occurrence in the first four decades of life (75%). Mucoceles are lesions commonly seen in an oral medicine service, mainly affecting young people and lower lips.
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Microbiological Analysis of Surfaces of Leonardo Da Vinci’s Atlantic Codex: Biodeterioration Risk
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Gianfranco Tarsitani
2014-01-01
Full Text Available Following the discovery of discoloration on some pages of the Atlantic Codex (AC of Leonardo da Vinci kept in the Biblioteca Ambrosiana in Milan, some investigations have been carried out to verify the presence of microorganisms, such as bacteria and fungi. To verify the presence of microorganisms a noninvasive method of sampling has been used that was efficient and allowed us to highlight the microbial facies of the material that was examined using conventional microbiological techniques. The microclimatic conditions in the storage room as well as the water content of the volume were also assessed. The combined observations allowed the conclusion that the discoloration of suspected biological origin on some pages of AC is not related to the presence or current attack of microbial agents.
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Directory of Open Access Journals (Sweden)
Daniele Villa
2014-05-01
Full Text Available Many new questions arise with regard to Web3.0- based technologies, which are more and more frequently used by non-experts to generate and share geographic information, new collective urban visions and place-based knowledge. This paper discusses the role of participatory planning and mapping practices in the context of Milan metropolitan region. In particular taking into account the collaborative use of new technologies (such as the use of microblogging and geo-social networks within the processes of social sharing of the great urban transformations. Specific attention is given to the problems of perception and definition of shared landscape quality. In this context, the role of expert knowledge in the analysis and definition of the social perception of the urban landscape is now changing rapidly and radically.
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Age- and Functional Status-Dependent Association Between Blood Pressure and Cognition
DEFF Research Database (Denmark)
Ogliari, Giulia; Sabayan, Behnam; Mari, Daniela
2015-01-01
OBJECTIVES: To evaluate whether the relationship between blood pressure (BP) measures and cognitive function is different according to age and functional status in older outpatients. DESIGN: Cross-sectional. SETTING: Outpatient hospital-based Milan Geriatrics 75+ Cohort Study. PARTICIPANTS......: Individuals aged 75 and older (N = 1,540). MEASUREMENTS: Blood pressure, Mini-Mental State Examination (MMSE), basic activities of daily living (ADLs), and instrumental activities of daily living (IADLs) were assessed. Associations between BP measures and MMSE score were first analyzed in the total population...... using linear regression models and were then further examined according to strata of age, ADLs, and IADLs. All analyses were adjusted for sociodemographic factors and presence of comorbidities. RESULTS: In the total population, higher systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean...
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La satira e la storia delle emozioni. Una relazione privilegiata?
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Dario Pasquini
2012-10-01
Full Text Available The present essay discusses interpretations of satire offered by different disciplines. Furthermore it hypothesizes that both verbal and visual satirical texts provide particularly useful evidences of the emotions related to a certain historical period or a certain context. The author analyzes sources from the satirical press, which has been the subject of his PhD research, and from the current affairs in order to proof the abovementioned hypothesis. Examples include articles and cartoons from satirical periodicals of the 1940s such as «Il Bertoldo», which was published in Milan, and «Ulenspiegel», which was published in Berlin. Furthermore the author analyzes comments posted by readers of on-line newspapers in relation to the recent lawsuit taken by Pope Benedict XVI against the German satirical magazines «Titanic».