WorldWideScience

Sample records for microvascular nuestra experiencia

  1. Esclerosis múltiple. : nuestra experiencia

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    Houlne, M.; Zalazar, M.; Sagaz, A.; López Laur, José Daniel

    2006-01-01

    Objetivos: analizar la experiencia obtenida y evaluar los resultados urodinámicos del estudio de 18 pacientes con esclerosis múltiple. Material y Métodos: se estudiaron 18 casos, valorándose la historia clínica, ecografía vesical y renal, analizándolos urodinámicamente con uroflujometría, residuo post miccional (RPM), cistotonometría y electromiografía esfinteriana. Urocultivo y antibiograma de orina. Resultados: del análisis de toda...

  2. Anestesia para colecistectomía laparoscópica: Nuestra experiencia Anesthesia for laparoscopic cholecystectomy: Our experience

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    Raúl García Rojas

    2006-06-01

    Full Text Available La cirugía de mínimo acceso se acompaña de variados cambios fisiopatológicos, por lo que requiere una adecuada monitorización y una atención anestésicas con características especiales. Realizamos un estudio prospectivo analítico con el objetivo de determinar el comportamiento transoperatorio, hemodinámico y respiratorio en este tipo de cirugía, determinar la correlación existente entre la presión arterial de dióxido de carbono (PaCO2 y el dióxido de carbono teleespiratorio (ETCO2 en los pacientes con y sin patologías cardiorrespiratorias previas, así como la morbilidad y la mortalidad asociadas al procedimiento. Observamos un aumento significativo de la presión pico en la vía aérea (f = 32,53; p = 0,0 y de la PaCO2 a los 5 min y a los 30 min después del neumoperitoneo. Existió una fuerte correlación lineal entre la PaCO2 y el ETCO2 en los pacientes sanos, pero no así en los enfermos. La tensión arterial diastólica experimentó un aumento significativo del 12 % y la frecuencia cardíaca una disminución de 7,1 %. Las náuseas y vómitos posoperatorios fueron las complicaciones más frecuentes (10 %. La colecistectomía laparoscópica, en nuestra experiencia, se acompañó de excelente estabilidad cardiorrespiratoria y una reducida morbilidad

  3. Nuestra experiencia en amigdalectomía en los años 2013-2017 en el Hospital Clínico Universitario de Valladolid

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    Ana Sánchez Martínez

    2018-05-01

    Full Text Available Introducción y objetivo: La amigdalectomía es un procedimiento frecuente en otorrinolaringología pediátrica. Actualmente se indica fundamentalmente en hipertrofia amigdalar asociada a trastorno obstructivo del sueño, amigdalitis de repetición o asimetría amigdalina. La hemorragia se considera la mayor complicación tras esta cirugía y la más temida; su incidencia se estima entre un 2 y un 5% pero las series varían bastante, documentándose hasta un 20% en algún estudio. Nuestro objetivo es revisar la experiencia en amigdalectomía durante los años 2013 al 2017.Material y Método: se realiza un estudio prospectivo de 442 pacientes sometidos a amigdalectomía asociada o no a adenoidectomía entre los años 2013-2017 en el Hospital Clínico Universitario de Valladolid. Hemos recogido datos relativos a la edad, sexo, diagnóstico, técnica quirúrgica, días de ingreso, hemorragia posquirúrgica y tratamiento realizado en este caso.Resultados: Hemos obtenido una muestra de 442 pacientes con edades comprendidas desde 1 año hasta los 78 años; el 76,9% fueron pacientes menores de 14 años. Respecto al sexo, el 45.9% fueron del sexo femenino y el 54.1% restante fueron del sexo masculino. Las principales indicaciones de cirugía fueron la amigdalitis de repetición y el síndrome de apnea hipopnea del sueño. Se realizaron un total de 315 adenoamigdalectomías y 121 amigdalectomías. En 6 pacientes la amigdalectomía fue unilateral por sospecha de neoplasia. La estancia media hospitalaria fue de 1,3 días. La técnica mas utilizada en nuestro hospital es disección fría y hemostasia con pinza bipolar  y compresión para las amigdalas y legrado con adenotomo para las adenoides, con compresión posterior para la hemostasia. Del total de pacientes, 20 sufrieron sangrado postquirúrgico (4.52%: 8 fueron inmediatos (primeras 24 horas, en 11 el sangrado fue tardío (a la semana y en un caso el paciente sangró en 2 ocasiones (en las primeras 24

  4. Malaria falciparum y síndrome nefrótico: nuestras experiencias Falciparum malaria and nephrotic Síndrome: Our experience

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    Jesús Juan Rodríguez

    2007-03-01

    Full Text Available Las especies de Plasmodium que infectan al hombre son: P. vivax, P. Malariae, P. Ovale y P. Falciparum. En Mozambique, como en la mayor parte de la llamada África Subsahariana, la especie predominante es P. falciparum cloroquina resistente. La infección por P. falciparum es potencialmente mortal, tiende a manifestarse como una enfermedad febril sin signos localizados o específicos. En los casos más graves, sin embargo puede presentarse asociada a variados síndromes clínicos que plantean serios retos terapéuticos.Es reconocido que la malaria o paludismo puede asociarse a síndrome nefrótico y se han dado explicaciones de esta relación patogénica. En Mozambique, en un período de seis meses, tuvimos la oportunidad de tratar tres casos de Malaria falciparum grave, asociado a síndrome nefrótico.Divulgar y trasmitir las experiencias prácticas y consideraciones teóricas a propósito de uno de estos casos es la motivación de los autores de este trabajo.Plasmodiumspecies infecting man are the following: P.vivax, P. Malariae, P. Ovale and P. Falciparum. In Mozambique, like the biggest area from the so called Subsaharian Africa,the resistent-chloroquine P. Falciparum is the predominating specie in this area. The P. Falciparum infection is potentially fatal, with a trend to show as a febrile condition with no localized or specific signs. In more severe cases, however, it may be presented in association with different clinical syndromes which represent serious therapeutic challenges. It is not unknown that Malaria or Paludism may be associated with the Nephrotic Syndrome, and many explanations have been given on this pathogenic relatioship. In a sixth month's period in Mozambique we had the chance to test three severe cases of Falciparum Malaria associated with a Nephrotic Syndrome. Spreading the practical experience and theoretic considerations on one of these cases is the aim of this work.

  5. Acute appendicitis in an incarcerated crural hernia: analysis of our experience Apendicitis aguda en una hernia crural incarcerada: análisis de nuestra experiencia

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    P. Priego

    2005-10-01

    Full Text Available Introduction: the finding of the vermiform appendix within a crural hernia (Amyand's hernia is a rare entity whose incidence is not described in the literature. Objective: the aim of this study was to report our hospital's experience in this kind of pathology. Material and methods: between 1993 and 2004, 4,572 acute appendicitis and 372 incarcerated crural hernia cases have been operated on in our hospital. We studied 6 cases of incarcerated crural hernia with vermiform appendix inside. We analyzed in retrospect the following parameters: age, sex, personal history, clinical manifestations, preoperative diagnosis, surgical technique, mean hospital stay, and outcome. Results: all patients were women with a mean age of 78.8 years. Most frequent clinical manifestations included pain and a mass in the right inguinocrural region, of variable intensity and duration. No clinical, laboratory, or radiographic signs help in reaching a correct preoperative diagnosis. General anesthesia and a crural approach are used in most surgical operations. In all cases an appendectomy was performed via the hernia sac, thus proving the presence of acute appendicitis in four of them (66.67%. A prosthetic mesh was used in 3 cases, and one case of wound infection was found. In the other cases we sutured the hernia ring using prolene. Conclusion: the finding of the appendix in an incarcerated crural hernia is a rare entity in old women that is difficult to diagnose preoperatively. Treatment includes appendectomy and herniorraphy. The use of prosthetic mesh is controversial.Introducción: la presencia del apéndice vermiforme en el interior de un saco herniario crural (hernia de Amyand constituye una entidad poco frecuente y cuya incidencia no está descrita en la literatura. Objetivo: el objetivo del trabajo es presentar la experiencia de nuestro hospital en este tipo de patología. Material y métodos: entre 1993 y 2004 se han intervenido en nuestro centro 4.572 pacientes

  6. Lipoatrofia semicircular: Nuestra experiencia dos años después (2007-2009 Semicircular Lipoatrophy: Our experience two years later (2007-2009

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    Antonio Ortega Díaz de Cevallos

    2009-12-01

    Full Text Available Fundamento y objetivos: Describir y analizar la presentación clínica y la evolución tras la corrección de determinados factores ambientales, de nuestra serie de casos de lipoatrofia semicircular en el entorno laboral, con especial atención a la resolución de la lesión y valorar la posible asociación con otras patologías desde el punto de vista etiológico o que pudieran formar parte de un síndrome más complejo. Pacientes y método: Trabajadores atendidos entre la primavera de 2007 y el verano de 2009. En la primera consulta se efectúa historia clínica detallada, con medición y localización de la lesión, realización de analítica y de ecografía de la zona supuestamente afecta. Posteriormente tras haberse tomado las medidas recomendadas en las empresas para eliminar la electricidad estática, se incluyen controles cada tres meses con anamnesis, exploración física y ecografía comparativas. Resultados: El 96,7% son mujeres, sin predominio de ninguna edad Todos trabajan en puestos con material informático y abundante cableado eléctrico. Las localizaciones, salvo 3 casos (2 en brazo y uno en región glútea, fueron a nivel de cara anterolateral de muslos y con valores medios de 69x20x73 cm. (altoxanchoxlargo. Evolutivamente a los 6 meses un 93% de casos mostraban remisión clínica (62% completa, 31% parcial; al año solamente 2 casos no han mostrado ninguna variación habiendo un 69% de resoluciones completas. Ningún caso ha presentado otra patología relacionada. En el primer año de control hubo 36 nuevos casos, en el segundo 22 y 4 en los 6 meses trascurridos del tercero. Conclusiones: Las características clínicas son superponibles a las de otras series publicadas en cuanto a manifestaciones, tipo de trabajador afecto y predominio de presentación en mujeres. En cuanto a la evolución una vez modificado el entorno laboral, es evidente la tendencia a la resolución, mucho más rápida que en los casos antiguamente

  7. Terapia fotodinámica (PDT en piel y estética: procedimiento, materiales y método en base a nuestra experiencia Photodinamic therapy in skin and aesthetics: procedure, matherials and method based on our experience

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    S. Mordon

    2012-09-01

    Full Text Available La terapia fotodinámica (PTD es un procedimiento cada vez más utilizado para tratar diversas afecciones dermatológicas y dermatoestéticas. Su aplicación obtiene buenos resultados en casos de carcinoma basocelular, enfermedad de Bowen, queratosis actínica, acné, rosácea y fotoenvejecimiento cutáneo. Los fotosensibilizantes y las fuentes de luz que se pueden utilizar son cada vez más variados, pero aún existe poco consenso en su metodología de aplicación, sistemas de irradiación y dosificaciones. En este artículo describimos los materiales y métodos disponibles en la actualidad y discutimos algunos detalles que, en base a nuestra experiencia, permiten mejorar los resultados. Presentamos también 5 casos clínicos ilustrativos de diferentes patologías.Photo Dynamic Therapy (PTD is an increasingly used technique in Dermatology and Dermocosmetics. PDT has a wide range of medical applications for the treatment of extended cutaneous cancer, offering also very good results in the treatment of basal cell carcinoma, Bowen's disease, actinic keratosis, acne, rosacea and in cutaneous rejuvenation. The sensitizers and light sources used for photoactivation are also more and more varied but there is still no consensus regarding methods and energy dosage. This study describes material and methods which are currently available and discusses a few details, that based on our own experience, can improve results. Five illustrative cases of different conditions are presented.

  8. Nuestra experiencia en el tratamiento de úlceras crónicas mediante PRF-Vivostat®: Serie de 10 casos Our experience in the treatment of chronic ulcers by PRP-Vivostat®: Series of 10 cases

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    E. Monclús Fuertes

    2009-06-01

    Full Text Available Pretendemos mostrar nuestra experiencia clínica en el manejo de úlceras crónicas de distinta etiología, mediante tratamiento conservador con gel rico en fibrina autóloga más factores de crecimiento plaquetarios o PRP, experiencia que reafirma los buenos resultados obtenidos en estudios anteriores referentes a Cirugía Plástica, Estética y Reparadora El hecho diferencial de nuestro estudio es el trato de las lesiones única y exclusivamente con PRP, sin otros tratamientos adyuvantes como es habitual en otros estudios acerca de este tema Entre los años 2002 y 2007 tratamos con PRP 10 pacientes con historia de fallo en los tratamientos convencionales, con una edad media de 65.6 años. Se realizaron entre 3 y 5 sesiones por paciente, espaciadas por una semana. El método de obtención elegido fue el sistema VIVOSTAT® (MBA Group. Se realizó un control fotográfico en cada sesión. Realizamos un seguimiento visual de las lesiones (pretratamiento- postratamiento, valorándolas según una modificación de la escala de Valbonesi et al a la que llamamos "Escala de Zaragoza", siendo el resultado pobre en 1 paciente, regular en 2, bueno en 5 y excelente en 2. El uso de PRP para úlceras crónicas en pacientes refractarios a otro tipo de tratamientos, tanto conservadores como quirúrgicos, es actualmente una alternativa real para conseguir una mejoría evidente e incluso la curación completa de las lesiones.The aim of this study is to evaluate our clinical experience in the management of chronic ulcers by conservative treatment with autologous fibrin-rich gel further platelet growth factors or PRP. This experience reaffirms the good results obtained in earlier studies relating to Plastic, Reconstructive and Aesthetic Surgery; moreover, the strength of our study is the use of PRP as the only treatment of such injuries, without other adjuvant treatments as usual in other works on this topic. From 2002 to 2007, we treated with PRP 10 patients with a

  9. El poder del testimonio, experiencias de mujeres

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    Rosana Paula Rodríguez

    2013-09-01

    experiencia singular. Las palabras de las mujeres que relatan experiencias corporales nombran una dimensión fundamental de nuestra experiencia, la de la diferencia sexual produciendo un dislocamiento en la presunta neutralidad de la lengua. Se trata de una reflexión que abre la posibilidad de poner palabras a lo innombrable.

  10. Elevación de seno maxilar: Análisis clínico de nuestra experiencia en más de 100 casos Clinical analysis of our experience in over 100 cases of maxillary sinus lift

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    Gui-Youn Cho-Lee

    2009-08-01

    Full Text Available Objetivos: La elevación de seno maxilar es uno de los procedimientos más versátiles en cirugía oral, de modo que hay descritos diversos abordajes, tipos de injertos, posibilidad de asociar otras técnicas preprotésicas y colocar implantes de manera simultánea o diferida, dependiendo de la altura ósea inicial. Nuestro propósito es comunicar nuestra experiencia después de intervenir 131 casos. Materiales y métodos: Se analizó una serie de 131 procedimientos llevados a cabo en 91 pacientes consecutivos, entre 1996 y 2007. La edad media fue de 50,43 años (23-69. El control radiológico pre y postoperatorio se realizó mediante ortopantomografía y TC dental. Se analizó la tasa de éxito implantario (implantes osteointegrados y cargados comparando los distintos injertos, el hábito tabáquico, las patologías asociadas y la colocación simultánea o diferida de los implantes. Así mismo, el tiempo (meses necesario para cargar la prótesis se ha comparado entre los diferentes tipos de injerto. Resultados: En las zonas aumentadas se colocaron un total de 228 implantes roscados. La altura preoperatoria media del suelo del seno fue de 6,59±2,11 mm y la postoperatoria de 14,57±2,33 mm. El seguimiento medio fue de 2,94 años (1-12. La tasa de éxito implantario global fue de 96,91%, no habiéndose encontrado diferencias significativas entre los distintos injertos, patologías asociadas o el hábito tabáquico. Conclusiones: En base a este análisis retrospectivo, se concluye que la elevación de seno es una técnica versátil, eficaz, segura y predecible; con una tasa de éxito implantario muy alta independiente del tipo de injerto, comorbilidad, hábito tabáquico y colocación simultánea o diferida de los implantes. El empleo de injerto óseo autólogo requiere un tiempo de espera para la carga protésica significativamente menor.Purpose: Maxillary sinus elevation surgery is one of the most versatile surgical procedures in maxillofacial

  11. NUESTRA PORTADA Juegos infantiles

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    Ramon Balius i Juli

    2008-09-01

    Full Text Available En Nuestra Portada se muestra un fragmento de la obra Juegos Infantiles (Kinderspelen, original del pintor flamenco Pieter Bruegel el Viejo. Pieter Bruegel ha sido un artista de valoración tardía. No fue hasta principios del siglo xx que la grandeza de su arte mereció el reconocimiento de los críticos. Sorprendentemente es prácticamente desconocido en su etapa de formación, porque únicamente existe una corta descripción biográfica publicada en 1604 por Van Manden. En esta bibliografía, Bruegel era presentado como un ignorante dedicado a la pintura cómica y campestre. Según Van Manden, había nacido en Bruegel, un pueblo cercano a Breda, del cual tomó el apellido. Esta afirmación es falsa, porque parece probado que lo había heredado de su padre. La realidad es, como señala en 1567 Ludovic Guicciardini, que “Pietro Brueghel de Breda es un gran imitador de la ciencia y de la fantasía de Hieronymus Bosco”. El año de nacimiento es incierto y se sitúa entre 1525 y 1530.

  12. Gastrojejunal anastomosis stricture after laparoscopic gastric bypass: Our experience with 62 patients Estenosis de la anastomosis gastroyeyunal en el bypass gástrico laparoscópico: Nuestra experiencia con 62 pacientes

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    A. Campillo-Soto

    2010-03-01

    complicación nada desdeñable en la cirugía bariátrica por laparoscopia, llegándose, en algunas series, a alcanzar el 15%. Presentamos nuestra casuística en una serie de 62 casos consecutivos y el manejo realizado. Pacientes y método: desde enero-2004 a septiembre-2006 hemos realizado de manera consecutiva 62 bypass gástricos por laparoscopia según técnica de Wittgrove modificada. La anastomosis gastroyeyunal se realiza con material de autosutura tipo CEAA nº 21 término-lateral (ILS; Ethicon y después de comprobar la estanqueidad anastomótica se dan dos puntos de válvula tipo Hoffmeister a cada lado de la anastomosis. En 4 casos (6,45% se reconvirtió a laparotomía, realizándose la anastomosis de la misma manera. El seguimiento tiene un rango de 3-35 meses, realizado en 61 enfermos, pues un paciente falleció por tromboembolismo pulmonar en el postoperatorio inmediato tras reintervención, a las dos semanas del bypass gástrico, por necrosis de un pequeño fragmento del remanente gástrico. En todos los pacientes con intolerancia persistente a la alimentación se realizó tránsito baritado y/o gastroscopia. Cuando se evidenció estenosis gastroyeyunal se procedió a dilatación neumática endoscópica (recomendando dilatar la anastomosis hasta como máximo 1,5 cm. Resultados: en 5 casos (8,1% se desarrolló una estenosis gastroyeyunal, en 4 de estos casos el diagnóstico inicial fue por tránsito baritado y en 1 caso por endoscopia. Dos pacientes tenían antecedentes de HDA que precisaron esclerosis endoscópica de la lesión sangrante (esclerosis circunferencial a las 48 horas de la cirugía y esclerosis de puntos sangrantes. Todos los casos se resolvieron mediante dilatación endoscópica, precisando en dos casos dos sesiones de dilatación y el resto una. En el seguimiento no se han detectado re-estenosis. Conclusión: la estenosis gastroyeyunal es consecuencia de realizar una anastomosis de pequeño calibre (con vistas a evitar así el r

  13. Parotiditis crónicas recidivantes: Nuestra experiencia

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    Manuel Estrada Sarmiento

    1998-08-01

    Full Text Available Se realizó una investigación observacional, prospectiva y descriptiva de 27 pacientes con el diagnóstico clínico e histopatológico de parotiditis crónica, con el objetivo de conocer su comportamiento en nuestro medio durante el período 1994-1995. De los 27 pacientes, 19 eran femeninos (70,4 % y 8 masculinos. En el 3,7 % se observó una edad inferior a los 10 años; la parótida izquierda fue la más afectada. La técnica quirúrgica de Blair se empleó en 19 pacientes (70,4 % y la mortalidad operativa fue nula. Cuatro pacientes (14,8 % presentaron complicaciones. Esta entidad es frecuente en niños, su cuadro clínico oscila entre meses y años, por lo cual no es poco frecuente después de las primeras décadas de la vida.An observational prospective and descriptive study of 27 patients clinically and histopathologically diagnosed with chronic parotitis was performed with the objective of finding out the behaviour of such disease in our context from 1994- to 1995. 19 were females (70.4 % and 8 were males. 3.7 % were under 10 years and the laft parotid gland was the most affected. Blair’s surgical technique was successfully used in 19 patients (70.4 % and none of them died. Complications occured in 4 patients (14.8 %. This disease is common in children, its clinical pattern ranges from months to years, so, it is not an uncommon disease after the first decades of life.

  14. Postconflicto y justicia transicional en Colombia: balance de nuestra experiencia

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    Carolina Rodríguez Rodríguez

    2011-01-01

    Full Text Available El estudio establece la relación entre el postconĚicto y la justicia transicional, integrando las conceptualizaciones realizadas por los especialistas nacionales e internacionales y los datos históri- cos y empíricos aportados desde las sociedades en transición. El propósito es analizar el caso colombiano a partir de estos refe- rentes, para esclarecer si el país vive una situación postconĚic - to y cuál es el balance de la aplicación de las estrategias de la justicia transicional consagradas en la Ley de Justicia y Paz (Ley 975 de 2005. De esta manera, la investigación articula elementos teóricos y fácticos, con la ęnalidad de generar recomendaciones normativas para la implementación futura de estrategias transi- cionales, teniendo como criterio regulativo el equilibrio entre la política y el derecho y, sobre todo, un papel activo de las víctimas y de la sociedad civil.

  15. La Memoria De Nuestra Tierra: Colorado

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    Baca, Judy

    2005-01-01

    La Memoria de Nuestra Tierra combines a meticulously hand-painted landscape with historic photographs in a seamless blend imprinted on the holographic-like surface of a metallic coated substrate. The mural for the Denver International Airport, entitled La Memoria de Nuestra Tierra is a breakthrough in digital murals, printed digitally on a…

  16. NUESTRA PORTADA. Jugar en la calle

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    Ramon Balius i Juli

    2008-06-01

    Full Text Available Esta vez Nuestra Portada tiene un carácter excepcional. La ocupan dos obras del que fue el “ninotaire” (dibujante de humor inteligente más importante de nuestro país: Francesc Vila i Rufas, conocido por todos como Cesc (1927–2006. Ambos dibujos destacan por sus inconfundibles características de sencillez y, a la vez, de grandeza argumental, que nos han movido a titular este comentario como “Jugar en la calle”. Comenzaré recordando mi precaria experiencia de infancia y primera juventud en esta actividad de índole “suburbana”. Son muchas las personas de mi edad que en algún momento de sus primeros años han jugado en la calle. Recuerdo que la primera vez que lo hice fue hacia 1938, en Sant Boi de Llobregat (denominado entonces Vilaboi, jugando al fútbol. Pasé unos meses en este pueblo huyendo de las bombas que caían sobre Barcelona. También por aquel tiempo, o quizá uno o dos años después, tuve el deseo, que no he podido satisfacer, de deslizarme sobre unos artefactos de madera con ruedas de cojinetes de bolas por la calle de Enric Granados, donde vivía (los construían los chicos del barrio, en formas rudimentarias, que hoy recordarían a los patinetes o los “skateboards”. Durante el bachillerato, al salir de la Escuela Pia de Balmes esquina con Travesera de Gracia, algunas veces había jugado también a fútbol en la calle Tuset, que por aquellos años no estaba bien urbanizada y tenía unas aceras amplísimas sin asfaltar. En los primeros cursos de la carrera de Medicina, participé en unos continuos e inacabables partidos de fútbol que, desde primera hora de la mañana y hasta el mediodía, se organizaban diariamente en el patio claustrado de la Facultad. Generalmente jugábamos entre clase y clase, aunque existía un núcleo de jugadores entusiastas que no entraban en las aulas en ningún momento. Esta competición se clausuró al cabo de bastantes años, cuando el Decano decidió adornar el patio con

  17. Microvascular Cranial Nerve Palsy

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    ... Español Eye Health / Eye Health A-Z Microvascular Cranial Nerve Palsy Sections What Is Microvascular Cranial Nerve Palsy? ... Microvascular Cranial Nerve Palsy Treatment What Is Microvascular Cranial Nerve Palsy? Leer en Español: ¿Qué es una parálisis ...

  18. ¿Cómo y dónde evalúa el cerebro las consecuencias de nuestras decisiones?

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    José L. Pardo-Vázquez

    2010-02-01

    Full Text Available Para aprender de la experiencia y ajustar nuestro comportamiento necesitamos evaluar las consecuencias de nuestra conducta. ¿Cómo y dónde tiene lugar esta evaluación en el cerebro? Recientemente hemos descrito que la información necesaria para alcanzar una decisión y evaluar sus consecuencias está representada en la corteza premotora ventral.

  19. Monólogos: nuestra pequeña esencia

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    Maria del Carmen Chenoll Monzó

    2010-01-01

    Full Text Available La siguiente experiencia práctica trata, como bien dice el título, sobre los monólogos de humor que tan de moda se han puesto últimamente.Muchas veces, cuando nos encontramos ante una clase de extranjeros que quieren estudiar español, se nos plantea el dilema de cómo separar las clases de cultura con las de gramática. ¿Y por qué separarlas? Los monólogos nos permiten combinar varios aspectos, como mostrarles a los alumnos nuestra cultura más de cerca y que ellos nos muestren y comenten la suya (fomentamos de esta manera una conversación espontánea en clase y de la que todos, hasta los más tímidos, suelen participar.Además, obviamente, existe un claro segundo sentido e ironía a la que poco a poco se acostumbran (y que es uno de los aspectos más difíciles para tratar con los alumnos de E/LE y por supuesto, con una acertada elección del monólogo, también podemos clarificar y profundizar en ciertos aspectos gramaticales que nos interesen.

  20. Fortaleciendo nuestra Organización Campesina

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    Van den Eeckhout, Hannes; Carrion, Daniel

    2011-01-01

    Fortalecer las organizaciones de productores es fundamental para la promoción y sustentabilidad de iniciativas tales como el proyecto AGROECO. Por esta razón, este articulo resalta las experiencias de supervisión y evaluación por parte de la Asociación Nacional de Productores Ecológicos (ANPE).

  1. Reconquistando nuestras ciudades históricas

    OpenAIRE

    Bordas Eddy, Marta; Usandizaga Calparsoro, Miguel M.

    2010-01-01

    Se propone una reflexión general sobre la necesidad de recuperar nuestras emblemáticas ciudades históricas y su arquitectura, para que sean devueltas a sus ciudadanos y usuarios. Se detecta una “museización” de dichas ciudades, en las que su carácter histórico y patrimonial parece primar sobre el derecho de libre movilidad y disfrute de las personas, minimizando la vida cotidiana urbana y transformando el entorno en puras imágenes para admirar en la distancia, en una especie de símil de patri...

  2. Simulaciones aumentadas: una experiencia contemporánea del territorio

    OpenAIRE

    Santamarina-Macho, Carlos

    2017-01-01

    Recientemente han comenzado a popularizarse los denominados juegos de realidad aumentada geolocalizada, aplicaciones tecnológicas que ofrecen una experiencia lúdica combinando el mundo real y virtual. El artículo analiza el modo en el que estas herramientas modifican nuestra experiencia territorial. Partiendo de su caracterización teórica, se describen primeramente algunos procesos de creación de “lugar” en el marco de estas realidades mixtas, para continuar con el análisis de su aplicación p...

  3. OBSERVACIONES PRÁCTICAS EN BASE A LA EXPERIENCIA AUDIOLÓGICA EN IMPLANTE COCLEAR

    Directory of Open Access Journals (Sweden)

    TM. Raquel Levy

    2016-11-01

    En base a nuestra experiencia como centro de referencia a nivel nacional en ésta área, deseamos entregar algunas orientaciones y describir las características más relevantes de los pacientes implantados de acuerdo a su rango etario.

  4. Infecciones quirúrgicas en cirugía maxilofacial: Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Jorge Luis Zequeira Peña

    2003-04-01

    Full Text Available Se realiza un estudio estadístico de 1 026 pacientes operados en el Servicio de Cirugía Maxilofacial del Hospital Provincial "Manuel Ascunce Domenech" en el año 2001, donde se constató infección quirúrgica en 35 de ellos (3,41 %; el mayor número de pacientes correspondió a 26 intervenidos de forma ambulatoria (3,39 %. La entidad nosológica más infectiva fue la cirugía ortognática (22,22 %. No se evidenció relación alguna entre los pacientes infectados y las enfermedades predisponentes.A statistical study was conducted among 1 026 patients that were operated on at the Maxillofacial Surgery Service of "Manuel Ascunce Domenech" Provincial Hospital in 2001. Surgical infection was confirmed in 35 of them (3.41 %. The highest number of patients corresponded to those who had undergone ambulatory surgery (3.39 %. The most infective nosological entity was orthognathic surgery (22.22 %. No relation was found between the infected patients and the predisposing diseases.

  5. Conversión de la colecistectomía videoendoscópica: Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Jorge Reyes Cardero

    2003-06-01

    Full Text Available En el período comprendido entre marzo de 1996 y junio de 2002 se operaron 2 508 pacientes de forma electiva, con el diagnóstico de enfermedad orgánica benigna de la vesícula biliar, en el Hospital General de Santiago de Cuba. A todos se les realizó colecistectomía videoendoscópica, de ellos fue necesario convertir a la técnica clásica o tradicional a un total de 57 pacientes, para el 2,2 %. La conversión predominó en los enfermos del sexo masculino, en los mayores de 51 años y como principales causas tenemos la dificultad anatómica plastrón vesicular crónica2 508 patients with the diagnosis of benign organic disease of the gall bladder were electively operated on at the General Hospital of Santiago de Cuba from March, 1996, to June, 2002. All of them underwent video-assisted cholecystectomy. In 57 of these patients, it was necessary to turn it into the classical or traditional technique, accounting for 2.2 %. The conversion predominated in male patients over 51. The chronic vesicular plastron anatomical difficulty was the main cause

  6. Our cumulative experience with transendoscopic miniprobes Nuestra experiencia acumulada con las minisondas transendoscópicas

    Directory of Open Access Journals (Sweden)

    M. J. Varas

    2005-06-01

    Full Text Available Introduction: transendoscopic miniprobes (TEMPs have nowadays precise indications, but may become a diagnostic alternative to both radial and sectorial endoscopic ultrasonography (EUS in the near future. Patients and methods: from November 1996 to July 2004 we carried out 620 examinations using TEMPs (124 during the last 12 months in 2003, with currently a mean of 11 examinations/month. Twenty explorations were performed with radial, 12.5 MHz (20 mm penetration, 6.2 F (2 mm diameter, 950 mm or 2000 mm Microvasive Endosound probes. Twenty explorations were performed using a 12 MHz (29 mm mean penetration or 20 MHz (18 mm penetration Olympus UM-2R/3R, or with a 12 MHz UM-DP12-25R or 20 MHz UM-DP20-25 R DPR-fitted Olympus probe, 2.5 mm in diameter and 2050 mm in length. A 20 MHz, 2.2 mm, wire-guided G20-29R was used for intraductal studies. In all, 580 examinations were carried out with both radial and linear, 12 MHz (240 E or 20 MHz (60 E Fuji probes, 2.6 mm in diameter and 1900 mm in length; and with a 7.5 MHz, 2.6 mm radial balloon microprobe with the well-known "preload" system that we have been using during the 1999-2004 period (280 E. Here we used a 3.2 mm working channel, whereas a 2.8 mm working channel was used with the remaining TEMPs. Results: twenty GI-tract examinations were performed with one Microvasive probe, which broke down when attempting its passage through the papilla. Currently we use a 20 MHz, 2.2 mm Olympus G20-29R guided microprobe for intraductal studies. We performed 100 gut examinations using one single Fuji TEMP (12 or 7.5 MHz. Organs explored included: esophagus and stomach, 60%; rectum and colon, 30%; other (duodenum, papilla, bile ducts, 10%. Indications: cancer staging, 35%; submucosal lesions, 30%; other, 35% (including 20% of esophageal non-tumoral conditions. Complications: aspiration, perforation, and mortality, 0%. Morbidity, 10%, at the expense of abdominal pain as induced by endoscopy itself. All strictures were successfully passed, except for one malignant stenosis in the rectum. Conclusions: during a 93-month period (1996-2004 we performed 620 explorations with TEMPs, with a current average of 11 examinations/month. TEMP durability is around 100 gut explorations. The esophagus and stomach were examined in 60% of cases. Primary indications included gut cancer staging and submucosal lesions (65%. Perforation and mortality rates amounted to 0%.Introducción: las minisondas transendoscópicas (MST poseen hoy en día unas indicaciones precisas, pero podrían ser en el futuro una alternativa a la Ultrasonografía Endoscópica (USE radial y sectorial en el área diagnóstica. Pacientes y método: desde noviembre de 1996 hasta julio del 2004, hemos realizado 620 exploraciones con MST (124 en los últimos 12 meses del año 2003; con una media de 11 exploraciones/mes actualmente. Veinte exploraciones se realizaron con una Microvasive Endosound, radial de 12.5 MHz (20 mm de penetración, de 6.2 F (2 mm de diámetro y de 950 y 2000 mm. Veinte exploraciones con Olympus, UM-2R/3R de 12 (29 mm de penetración media y 20 MHz (18 mm de penetración, UM-DP12-25R y UM-DP20-25 R de 12 y 20 MHz respectivamente y 2,5 mm de diámetro con sistema DPR, y 2050 mm de longitud. Para estudio intraductal se utilizó G20-29R de 20 MHz, 2,2 mm y con guía. Quinientas ochenta exploraciones con MST Fuji, radial y lineal, de 12 MHz (240 E y 20 MHz (60 E, de 2,6 mm de diámetro, y 1900 mm de longitud; y una microsonda radial con balón, de 7,5 MHz y 2,6 mm de diámetro con el sistema conocido de "pre-carga", que utilizamos desde 1999-2004 (280 E. El canal de trabajo utilizado fue de 3,2 mm, mientras que en con el resto de las MST se utilizó un canal de trabajo de 2,8 mm. Resultados: con la misma MST de Microvasive se realizaron 20 exploraciones del tracto digestivo rompiéndose al intentar introducirla por la papila. Actualmente utilizamos Olympus G20-29R de 20 MHz, 2,2 mm, con guía, para el estudio intraductal. Con la misma MST de Fuji (12 ó 7,5 MHz hemos realizado 100 exploraciones del tracto digestivo. Órgano a explorar: el esófago y el estómago 60%, el recto y el colon el 30%, miscelánea (duodeno, papila, vía biliar 10%. Indicación: estadificación del cáncer 35%, lesión submucosa 30%, miscelánea 35% (incluyendo un 20% de patología esofágica no tumoral. Complicaciones: aspiración, perforación y mortalidad del 0%. Morbilidad del 10% a expensas del dolor abdominal provocado por la realización de la endoscopia. Todas las estenosis se pudieron atravesar, menos una estenosis maligna rectal. Conclusiones: en un periodo de 93 meses (1996-2004 hemos realizado 620 exploraciones con MST, actualmente con un promedio de 11 exploraciones/mes. La durabilidad de la MST está alrededor de las 100 exploraciones del tracto digestivo. En el 60% de los casos se exploró el esófago y el estómago. La indicaciones fundamentales fueron la estadificación del cáncer del tubo digestivo y las lesiones submucosas (65%. Los porcentajes de perforación y mortalidad fueron del 0%.

  7. Morbilidad y mortalidad por afecciones benignas del sistema biliar: Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Jorge Reyes Cardero

    1997-04-01

    Full Text Available Se realizó un estudio descriptivo y prospectivo sobre morbilidad y mortalidad por enfermedades benignas del sistema biliar en 4 266 pacientes operados en el Hospital Provincial Clinicoquirúrgico Docente "Saturnino Lora" de Santiago de Cuba, en el que se precisó la incidencia de diferentes variables. Las enfermedades más frecuentes fueron las colecistitis y colecistosis, en pacientes del sexo femenino, y un número importante de operados superaba los 60 años. Las complicaciones más comúnmente halladas en el período preoperatorio fueron: la litiasis coledociana y la pancreatitis aguda; en el peroperatorio: sobre la vesícula, la vía biliar y el hígado y en el posoperatorio inmediato las inespecíficas, que prevalecieron sobre las específicas. La mortalidad se consideró dentro de límites aceptables, y como causa fundamental de muerte en los ancianos se destaca el síndrome de disfunción múltiple de órganosA descriptive and prospective study on morbidity and mortality of bening diseases of the biliary tract was performed on 4 266 patients operated on at "Saturnino Lora" Provincial Teaching hospital, Santiago de Cuba with the aim of assessing the incidence of different variables. The most frequent diseases were found to be cholecystitis and cholecystosis in female patients, and a great number of surgically treated patients were over 60 years of age. The most frequently complications found within the preoperative period were: cholelithiasis and acute pancreatitis; during the perioperative period the most common were the complications of the gall bladder, the bile duct, and the liver, and during the immediate portoperative period the most frequent complications were found to be nonspecific which prevailed over the specific ones. Mortality rate was considered to be within acceptable limits, and the syndrome of multiple organ failure was found to be the principal cause of death among aged patients

  8. Manejo de la Gangrena de Fournier: Nuestra experiencia / Fourniers Gangrene Management: Our Experience

    OpenAIRE

    Etcheverry MG; Pierini A; Brosutti O; Ruiz G; Canga V

    2015-01-01

    Fournier ‘s gangrene (GF) is an infection that rapidly expands and affects the perineum, perianal region and the external genitalia. Without early treatment, based on life support, antibiotics and surgery it has a high mortality, even today. A retrospective, observational study was performed. All patients treated for GF in General Surgery third level hospital for the period between January 2002 and April 2014 were included. 23 patients are described and several variables regarding the diag...

  9. Manejo de la Gangrena de Fournier: Nuestra experiencia / Fourniers Gangrene Management: Our Experience

    Directory of Open Access Journals (Sweden)

    Etcheverry MG

    2015-11-01

    Full Text Available Fournier ‘s gangrene (GF is an infection that rapidly expands and affects the perineum, perianal region and the external genitalia. Without early treatment, based on life support, antibiotics and surgery it has a high mortality, even today. A retrospective, observational study was performed. All patients treated for GF in General Surgery third level hospital for the period between January 2002 and April 2014 were included. 23 patients are described and several variables regarding the diagnosis, treatment and monitoring of these patients were analized.

  10. Construyendo nuestra felicidad para ayudar a construirla

    Directory of Open Access Journals (Sweden)

    María Rosario Fernández Domínguez

    2009-01-01

    Full Text Available A lo largo de este trabajo se ofrece una visión de la felicidad y del bienestar como un proceso, como algo a construir a través de una dinámica de desarrollo y crecimiento personal que conduzca, a través del autoconocimiento, a ser más equilibrados, serenos y capaces de disfrutar de lo que hacemos y de lo que vivimos. Analizamos qué es para nosotros la felicidad, insistiendo en que ésta no consiste en tenerlo todo, o en no tener problemas ni dificultades, que, en definitiva, no reside en el exterior sino que está en nuestro interior, resaltando que es posible conquistarla. Situándonos en la perspectiva de la psicología humanista, la conectamos con la psicología positiva, cuyos orígenes se remontan a aquella, y hacemos una breve revisión del concepto de felicidad a través de diferentes autores, representantes de la psicología humanista. Finalmente, terminamos centrándonos en la perspectiva de Personalidad y Relaciones Humanas (PRH, muy cercana a la visión rogeriana. Para Personalidad y Relaciones Humanas la felicidad se puede ir conquistando poco a poco, estando muy ligada a un proceso de crecimiento interior que conduzca a la persona a ser cada vez más ella misma, desplegando todas sus potencialidades, a no vivir pendiente del éxito social o del parecer, a lograr tener el poder sobre su propia vida, sintiéndose cada vez más libre de las ataduras externas e internas; al sentido de la propia existencia, etc. Por ello, analizamos también en qué consiste crecer y qué es lo que favorece y dificulta este proceso de crecimiento interior. Situados en esta perspectiva, defendemos que la felicidad y el optimismo ante la vida es algo que no se adquiere porque sí, o sólo porque queremos. Requiere de un profundo y prolongado trabajo interior, para conocer nuestras potencialidades y límites y poder actualizarlas y ayudar a que crezcan en nuestra vida y relaciones. Pero, para crecer en libertad, alegría, optimismo, capacidad de amar

  11. Visión activa y aprendizaje perceptual: Cómo la experiencia cambia nuestro mundo visual

    Directory of Open Access Journals (Sweden)

    Carlos M. Hamamé

    2011-06-01

    Full Text Available Nuestra experiencia es capaz de modificar el modo en que percibimos. Este tipo de aprendizaje perceptual nos indica la importancia del observador en la construcción de la percepción. En este artículo se examinan evidencias neurofisiológicas recientes que demuestran la presencia, no sólo de procesos perceptuales, sino también atencionales y de actualización de contexto, en el modo en que nuestra percepción visual cambia con la experiencia. Considerar la experiencia sensorial, junto con el estado actual del observador, ayudará a completar los modelos actuales, que son insuficientes para explicar la visión en condiciones naturales.

  12. Microvascular inflammation in atherosclerosis

    Directory of Open Access Journals (Sweden)

    Laura Vitiello

    2014-06-01

    Full Text Available Atherogenesis is the pathogenetic process leading to formation of the atheroma lesion. It is associated to a chronic inflammatory state initially stimulated by an aberrant accumulation of lipid molecules beyond the endothelial barrier. This event triggers a cascade of deleterious events mainly through immune cell stimulation with the consequent liberation of potent pro-inflammatory and tissue damaging mediators. The atherogenetic process implies marked modifications of endothelial cell functions and a radical change in the endothelial–leukocyte interaction pattern. Moreover, accumulating evidence shows an important link between microvascular and inflammatory responses and major cardiovascular risk factors. This review illustrates the current knowledge on the effects of obesity, hypercholesterolemia and diabetes on microcirculation; their pathophysiological implications will be discussed.

  13. Protegiendo Nuestra Comunidad: empowerment participatory education for HIV prevention.

    Science.gov (United States)

    McQuiston, C; Choi-Hevel, S; Clawson, M

    2001-10-01

    To be effective, HIV/AIDS interventions must be culturally and linguistically appropriate and must occur within the context of the specific community in which they are delivered. In this article, the development of a culture-specific lay health advisor (LHA) program, Protegiendo Nuestra Comunidad, for recently immigrated Mexicans is described. This program is one component of a collaborative inquiry research project involving community participants and researchers working as partners in carrying out and assessing a program for the prevention of HIV/AIDS. The collaborative inquiry process was applied as an empowerment philosophy and methodology of Paulo Freire and an ecological framework was used for the development of Protegiendo Nuestra Comunidad. The use of principles of empowerment for curriculum development, teaching methodology, and program delivery are described.

  14. Supervivencia en hemodiálisis vs. diálisis peritoneal y por transferencia de técnica. Experiencia en Ourense 1976-2012

    Directory of Open Access Journals (Sweden)

    Alfonso Otero González

    2015-11-01

    Conclusión: En nuestra experiencia, la SV en TRS es dependiente de la edad y la coexistencia de DM y sería conveniente retomar el concepto de «cuidados integrales» comenzado la TRS por DP y transferir a HD.

  15. Cuerpos del Discurso y Discurso de los Cuerpos. Nietzsche y Bajtin en nuestras relaciones interculturales.

    Directory of Open Access Journals (Sweden)

    José Luis Grosso

    2009-12-01

    Full Text Available

    La lucha cultural en la imposición de sentidos que devela la crítica genealógica nietzscheana encuentra en Bajtin su concreción sociológica en el concepto de “interacción discursiva” y su radical alteridad fundante en el concepto de “discurso ajeno”. Así, la trama cuerpo-sentido-poder es puesta en situación. Las relaciones interculturales en que (convivimos en las diversas regiones latinoamericanas complican aquella trama, volviéndola abigarrada, barroca, anudada de silencios, dolor, autonegaciones, desconocimientos, en la que el elemento festivo esencial de toda cultura da lugar a las maneras singulares de la burla, la risa, el escamoteo y el sacrificio. En este trabajo, luego de presentar algunos conceptos fundamentales de Friedrich Nietzsche (especialmente de La Genealogía de la Moral y de Mijail Bajtin (especialmente de El Marxismo y la Filosofía del Lenguaje, me referiré a la trama constitutiva de nuestras relaciones interculturales en nuestra experiencia colonial y nacional, desde una posición interpretativa poscolonial, y, finalmente, me detendré en esa trama en la socialidad de la risa y la burla y en el sentimiento de “añoranza”, que encuentra su largo y desbordado cauce en la música, como existenciarios que caracterizan y diferencian a los “santiagueños” en Argentina (José Luis Grosso. Indios Muertos, Negros Invisibles. Los santiagueños en Argentina. Dichos existenciarios constituyen las matrices epistémicas, emotivas y políticas de los procesos de subjetivación en el juego identidad/alteridad que van sedimentando en las historias de los cuerpos. Aportes de otros autores, tales como Jacques Derrida, Pierre Bourdieu, Michel de Certeau y Rodolfo Kusch, tendrán también un relieve crítico muy

  16. Cuerpos del Discurso y Discurso de los Cuerpos. Nietzsche y Bajtin en nuestras relaciones interculturales.

    Directory of Open Access Journals (Sweden)

    José Luis Grosso

    2009-12-01

    Full Text Available La lucha cultural en la imposición de sentidos que devela la crítica genealógica nietzscheana encuentra en Bajtin su concreción sociológica en el concepto de “interacción discursiva” y su radical alteridad fundante en el concepto de “discurso ajeno”. Así, la trama cuerpo-sentido-poder es puesta en situación. Las relaciones interculturales en que (convivimos en las diversas regiones latinoamericanas complican aquella trama, volviéndola abigarrada, barroca, anudada de silencios, dolor, autonegaciones, desconocimientos, en la que el elemento festivo esencial de toda cultura da lugar a las maneras singulares de la burla, la risa, el escamoteo y el sacrificio. En este trabajo, luego de presentar algunos conceptos fundamentales de Friedrich Nietzsche (especialmente de La Genealogía de la Moral y de Mijail Bajtin (especialmente de El Marxismo y la Filosofía del Lenguaje, me referiré a la trama constitutiva de nuestras relaciones interculturales en nuestra experiencia colonial y nacional, desde una posición interpretativa poscolonial, y, finalmente, me detendré en esa trama en la socialidad de la risa y la burla y en el sentimiento de “añoranza”, que encuentra su largo y desbordado cauce en la música, como existenciarios que caracterizan y diferencian a los “santiagueños” en Argentina (José Luis Grosso. Indios Muertos, Negros Invisibles. Los santiagueños en Argentina. Dichos existenciarios constituyen las matrices epistémicas, emotivas y políticas de los procesos de subjetivación en el juego identidad/alteridad que van sedimentando en las historias de los cuerpos. Aportes de otros autores, tales como Jacques Derrida, Pierre Bourdieu, Michel de Certeau y Rodolfo Kusch, tendrán también un relieve crítico muy significativo en este trabajo.  Fecha de recepción: 30 octubre 2009. Fecha de aceptación: 05 de diciembre 2009.

  17. Microvascular Recruitment in Insulin Resistance

    DEFF Research Database (Denmark)

    Sjøberg, Kim Anker

    the resonating sound from the microbubbles in the systemic circulation were recorded for determination of microvascular recruitment in designated muscle segments. Results showed that microvascular recruitment increased with insulin stimulation by ~30% in rats and ~40% in humans (study I). Furthermore......, it was observed that muscle contractions increased muscle perfusion rapidly by 3-4 fold and by 1-2 fold compared to basal and insulin, respectively, in both rat and human skeletal muscle (study I). The real-time contrast-enhanced ultrasound method was applied to investigate the vaso-active effect of the incretin...... hormone glucagon-like-peptide-1 (GLP-1) in the microcirculation. Glucagon-like-peptide-1 analogs are drugs used for treatments of insulin resistance and type 2 diabetes but the vascular effects of GLP-1 in vivo are elusive. Here it was shown that GLP-1 rapidly increased the microvascular recruitment...

  18. Nuestra Experiencia con la técnica de Barcat y Godart en el Torticolis Muscular Congénito

    OpenAIRE

    Remartínez Rivares, José María; Latorre Sahún, A.; Castiella Muruzabal, Tomás; Aznar Aznarez, J. Mª; Seral Iñigo, Fernando

    1990-01-01

    Los autores exponen los resultados obtenidos en diez casos de T.M.C. tratados quirúrgicamente con la técnica de Barcat y Godard, tanto estéticos como funcionales. Se analizan los parámetros de sexo, edad de intervención, lado afectado, tipo de parto, anomalías asociadas, y presencia de asimetría facial, movilidad craneal, pérdida de relieve muscular y aparición de bandas laterales postoperatorias. Estos resultados son comparados con los otros autores, mostrándose superiores....

  19. Cirugía coronaria con doble arteria mamaria: nuestra experiencia inicial y resultados a corto plazo

    Directory of Open Access Journals (Sweden)

    Jorge Alcocer-Diéguez

    2017-05-01

    Conclusiones: La cirugía coronaria con doble mamaria es una técnica segura y con excelentes resultados de morbimortalidad a corto plazo. Son necesarios estudios de seguimiento clínico y angiográfico a largo plazo para determinar la mejor estrategia quirúrgica a emplear.

  20. Tumor de Pancoast: nuestra experiencia en 20 años Pancoast tumor: our experience of 20 years

    Directory of Open Access Journals (Sweden)

    Bárbaro Agustín Armas Pérez

    2007-03-01

    Full Text Available Se realizó un estudio descriptivo transversal de 11 pacientes operados por tumor de Pancoast, en el transcurso de dos decenios. Se hizo una revisión bibliográfica amplia del tema haciendo énfasis en el diagnóstico, estadificación y tratamiento. El mayor porcentaje de pacientes era del sexo masculino, fumadores y portadores de masas radiopacas tenues en el vértice, las cuales se acompañaban de dolor en pared costal irradiado a hombro, brazo y cuello. No siempre la resección quirúrgica fue completa y radical y los pacientes que presentaron mejores índices de supervivencia fueron los tratados mediante cirugía excerética amplia y terapia neoadyuvante. La vía de abordaje más utilizada fue la posterolateral y en un sólo caso la anterior-transcervical, que mucho nos satisfizo. La supervivencia fue corta aunque la serie es pequeña y no hubo mortalidad antes de los 30 días tras la operación

  1. Crisis en el gobierno de nuestras universidades públicas

    Directory of Open Access Journals (Sweden)

    Luis Porter Galetar

    1999-11-01

    Full Text Available En este artículo se hace una crítica de la forma en que se gobierna la educación superior, tanto a nivel federal como a nivel institucional, en México. Plantea que ante un futuro demasiado incierto, nuestra desgastada cultura política, sumada al difícil momento de transición histórica que vivimos, podría estar anticipando nuevas "sorpresas" tan graves como el actual caso de la prolongada huelga en la UNAM. El artículo propone el análisis de algunas características de las prácticas de gobierno tradicionales y deterministas, y se recomienda abandonar la actual separación entre el pensar y el actuar, haciendo una reflexión en la acción que ayude a la transformación real de nuestras IES. Se hace un llamado a que los actores de la educación superior recuperen la capacidad de crear un nuevo futuro, con mayor imaginación y con base en las posibilidades que somos capaces de visualizar como posibles. Se hace también un llamado para que el gobierno y sus políticas educativas, en vez de intentar predecir y fantasear con metas y objetivos inverosímiles, sirvan para construir caminos y para transitar por ellos hacia ese futuro cuya creación es resultado de la acción individual y colectiva.

  2. experiencias en el sistema

    Directory of Open Access Journals (Sweden)

    B. Fernández Manjón

    2005-01-01

    Full Text Available En este trabajo se presenta la experiencia de aplicación e implementación del modelo de objetos educativos en el sistema . Se describe una visión práctica de la aplicación de las tecnologías de marcado tanto en la estructuración de los cursos como en el desarrollo de contenidos que pueden ser adaptados al usuario. En se han seguido las especificaciones de IMS, desarrollándose un soporte completo del empaquetamiento de cursos (content packaging reflejado en un sistema de autoría de cursos y una herramienta de importación. Además se ha particularizado un perfil específico de cursos y de objetos educativos que permiten su adaptación al usuario.

  3. Experiencia Educacional en Paraguay.

    Directory of Open Access Journals (Sweden)

    Mari Blanca Pavon.

    Full Text Available La experiencia educacional que presentaré concierne al grupo indígena de los guaraníes del Paraguay que se autodenominan Karaguy  jara, que quiere decir  "dueños del monte". También se denominan Avá chiiripá. Esta etnia vive en la región oriental del Paraguay. en un triángulo que se extiende hacia el Brasil. En este mismo sector viven también los Paitauytera, los Mbya y los llamados Ache o Guayaki o Atchi. Se supone .que existen alrededor de 4.500 Avá Chiripá en la región oriental del Paraguay. Viven en pequeñas comunidades y han perdido su hábitat selvático natural casi en su totalidad.

  4. El tratamiento de los estereotipos en el aula de ELE: una experiencia práctica

    Directory of Open Access Journals (Sweden)

    Elena Jiménez García

    2009-01-01

    Full Text Available En la docencia de español como lengua extranjera es fundamental el tratamiento de los estereotipos con el objetivo de favorecer el reconocimiento del contexto sociocultural de la lengua de aprendizaje y evitar una visión distorsionada que se aleje de la realidad.Nos hemos planteado ofrecer una posible panorámica de cómo enfocar estos aspectos en el aula de E/LE, basándonos en nuestra experiencia práctica con dos grupos de estudiantes de nivel B1: un grupo de nueve estudiantes universitarios alemanes y otro grupo de doce estudiantes preuniversitarios ingleses.

  5. El tratamiento de los estereotipos en el aula de ELE: una experiencia práctica

    Directory of Open Access Journals (Sweden)

    Elena Jiménez García

    2012-08-01

    Full Text Available En la docencia de español como lengua extranjera es fundamental el tratamientode los estereotipos con el objetivo de favorecer el reconocimiento del contextosociocultural de la lengua de aprendizaje y evitar una visión distorsionada que se alejede la realidad.Nos hemos planteado ofrecer una posible panorámica de cómo enfocar estosaspectos en el aula de E/LE, basándonos en nuestra experiencia práctica con dos gruposde estudiantes de nivel B1: un grupo de nueve estudiantes universitarios alemanes y otrogrupo de doce estudiantes preuniversitarios ingleses.

  6. Editorial "Homenaje a una de nuestras más destacadas colaboradoras, la Dra. Ninoska Maneiro Malavé".

    Directory of Open Access Journals (Sweden)

    Ivan Santelices Malfanti

    2011-04-01

    Full Text Available En esta edición de la Revista Ingeniería Industrial sentimos el deber de hacer un paréntesis: rendir un merecido homenaje a una de nuestras más destacadas colaboradoras, la Dra. Ninoska Maneiro Malavé, profesora de la Universidad de Carabobo, Venezuela, recientemente fallecida. La doctora Maneiro, miembro de nuestro Comité Editor, compartió  muchas experiencias con nosotros, demostrando siempre un gran amor por la ciencia, por la investigación y la divulgación de ésta. Cuando hablaba de la revista se refería a ella como si se tratara de su propio hogar, de su familia. Decía sentirnos como sus propios amigos, y veía en esta publicación una parte de su propia patria afectiva. Así la recuerdan hoy sus amigos y colegas. Así la recordamos nosotros: como una gran profesional y, sobre todo, como un gran ser humano. La revista Ingeniería Industrial, en nombre de la ciencia, en nombre de la investigación, y en nombre de todos quienes la hacemos, expresa el más profundo sentimiento de pesar por su ausencia repentina.

  7. La experiencia semestral

    Directory of Open Access Journals (Sweden)

    Heidi Cañón

    2003-11-01

    Full Text Available La Corporación Opción Colombia brinda a los estudiantes universitarios la posibilidad de confrontar la teoría de las aulas con la realidad del país. Quienes aplican al programa reciben talleres de capacitación e información sobre los convenios vigentes y los perfiles requeridos par cada uno de ellos. Superada esta primera etapa y de acuerdo con sus expectativas, el estudiante aplica a algunos de los proyectos y la corporación se encarga de ubicarlo en alguna zona del país. En este artículo, el lector conocerá el caso de una estudiante de la Facultad de Administración de Empresas Turísticas y Hoteleras, quien fue ubicada en los municipios Pijao y La Tebaida (Quindío para desarrollar actividades dentro del programa Computadores para Educar, iniciativa que busca proveer de tecnología a las escuelas públicas. La autora deja entrever sus emociones, su visión antes y después de esta experiencia y los aportes dados y recibidos durante el proceso.

  8. EDITORIAL - NUESTRA RESPONSABILIDAD SOBRE LA GENERACIÓN DE CONOCIMIENTO

    Directory of Open Access Journals (Sweden)

    Carulla Fornaguera Juan Evangelista

    2007-11-01

    Full Text Available El siglo XX se caracterizó por un crecimiento exponencial del conocimiento, caso excepcional en la historia de la humanidad. Los países que han basado su desarrollo en la generación de conocimiento y su aplicación al desenvolvimiento tecnológico lideran el escenario mundial. En este sentido, Colombia esta aún muy rezagada en la generación de conocimiento y desarrollo tecnológico. Es más, podríamos afirmar que estamos menos preparados que hace unos años. El desmonte de las responsabilidades de investigación al Instituto Colombiano Agropecuario para transferirlas a una entidad de carácter mixto como Corpoica ha tenido serias dificultades y no ha arrojado los resultados esperados. El mayor perjuicio de este modelo, emprendido por el país hace más de diez años, ha sido un claro menoscabo del recurso humano de ambas instituciones con consecuencias que apenas empezamos a vislumbrar. Por otro lado, las universidades hemos empezado a asumir responsabilidades en la generación de conocimiento y desarrollo tecnológico. Este modelo de universidad comprometida con el desarrollo de conocimiento merecerá un esfuerzo mayor para que sea exitoso. Hasta hace poco tiempo, nuestras universidades se preocuparon principalmente por la formación de los profesionales sin asumir su responsabilidad en la generación de conocimiento y desarrollo tecnológico, elementos indispensables para dar soluciones a las problemáticas de nuestro sector. Aún más grave, muchas de nuestras universidades no consideran esta función como un elemento central de su política, y tampoco cuentan con el recurso humano o la infraestructura para hacerlo. En la Universidad Nacional hemos asumido este reto como lo demuestra la importante participación en la reciente convocatoria para la “cofinanciación de programas y proyectos de investigación, desarrollo tecnológico e innovación para el sector agropecuario” del Ministerio de Agricultura y Desarrollo Rural, donde

  9. La educación inclusiva es nuestra tarea

    Directory of Open Access Journals (Sweden)

    Meybol Calderón

    2012-06-01

    Full Text Available La educación inclusiva es un tema que se ha venido trabajando desde hace relativamente pocos años en el Perú, pero en otros países se viene realizando desde hace muchos años. Por ello esta investigación busca dar a conocer todos aquellos elementos que son necesarios para lograr una inclusión adecuada de los niños, tomando como centro al niño, reconociéndolo como un ser humano integral que no solo aprende conceptos, sino también aprende a convivir e interactuar con su medio. Es aquí donde debemos tomar en cuenta el respeto a la diversidad que se debe dar en el aula, ya que al convivir se comparten experiencias con personas diferentes, como pueden ser los niños con necesidades especiales o simplemente con las de un niño regular. En esta investigación hemos querido resaltar la importancia de los roles de los agentes educativos para el buen desarrollo de la inclusión de los niños, siendo estos indispensables para lograrlo.

  10. Revascularización miocárdica con uso de doble arteria mamaria interna y morbilidad esternal. Experiencia de un centro

    Directory of Open Access Journals (Sweden)

    Sara Badia

    2017-05-01

    Conclusiones: En nuestra experiencia, la utilización de doble mamaria no se acompañó de mayor incidencia de dehiscencia esternal, pero si con problemas de infección superficial de la herida, sobre todo en el grupo de pacientes mujeres, con insuficiencia renal y transfundidos en quirófano. Para mantener el beneficio de la doble mamaria en estos pacientes, deberíamos ser especialmente cuidadosos e implementar nuevas estrategias de cierre esternal.

  11. Microvascularization on collared peccary placenta

    DEFF Research Database (Denmark)

    Santos, Tatiana Carlesso; Oliveira, Moacir Franco; Dantzer, Vibeke

    2012-01-01

    and fetal compartments of the placentae. The immunolocalization of vimentin in the vascular endothelium and in the smooth muscle cells of blood vessels showed indented capillaries along the uterine epithelium and the trophoblast at the sides of complementary maternal and fetal microfolds, or rugae...... into a microvascular network wall in a basket-like fashion. At the base of these baskets venules were formed. On the fetal side, arterioles branched centrally in the fetal rugae into a capillary network in a bulbous form, complementary to the opposite maternal depressions forming the baskets. At the base...

  12. El afecto y el cuidado como una experiencia de aprendizaje en familias víctimas de violencia intrafamiliar

    Directory of Open Access Journals (Sweden)

    Sandra Posada Bernal

    2013-06-01

    Full Text Available Si desde nuestra infancia aprendemos comportamientos violentos y tendemos a reproducirlos en nuestra adultez con nuestros compañeros, pareja, familia e hijos, podríamos también aprender comportamientos de afecto y cuidado que rompan esa forma de relacionarse con los demás a través del acto violento. En este documento trataremos de mostrar a la luz de los conceptos de familia, violencia intrafamiliar -VIF-, resolución pacífica de conflictos y roles de género, cómo el afecto y el cuidado pueden convertirse en una experiencia de aprendizaje en beneficio de las familias víctimas de violencia.

  13. Experimental diode laser-assisted microvascular anastomosis.

    Science.gov (United States)

    Reali, U M; Gelli, R; Giannotti, V; Gori, F; Pratesi, R; Pini, R

    1993-05-01

    An experimental study to evaluate a diode-laser approach to microvascular end-to-end anastomoses is reported. Studies were carried out on the femoral arteries and veins of Wistar rats, and effective welding of vessel tissue was obtained at low laser power, by enhancing laser absorption with indocyanine green (Cardio-green) solution. The histologic and surgical effects of this laser technique were examined and compared with those of conventional microvascular sutured anastomoses.

  14. Liberación y desautomatización. La experiencia mística en perspectiva naturalizada

    Directory of Open Access Journals (Sweden)

    Lina Marcela Cadavid Ramírez

    2014-01-01

    Full Text Available Tradicionalmente, la experiencia mística tiene como uno de sus propósitos fundamentales alcanzar la liberación. Esta puede entenderse como el resultado de la superación de los condicionamientos del ego que permite el encuentro con nuestra mismidad. Se analiza la liberación desde un discurso epistemológico naturalizado, entendiéndola como un proceso de desautomatización que repercute sobre el sistema nervioso central y que suscita una transformación radical en la relación habitual que el hombre tiene con el mundo.

  15. El trabajo colegiado, un espacio para narrar las experiencias desde la práctica docente

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    Maríadel Rosario Landín Miranda

    2016-01-01

    Full Text Available Gestionar el aprendizaje y reaprendizaje durante el profesorado es todo un reto y todo un campo de estudio, por ello, en este trabajo, presentamos nuestra experiencia en la implementación de un proyecto de intervención que tuvo como propósito principal, generar un espacio colegiado para el aprendizaje de las experiencias docentes. El proyecto se implementó en la Escuela Secundaria Artículo 3° de Poza Rica, Veracruz, México, durante el periodo de agosto de 2014 a julio de 2015. La metodología base usada para el desarrollo del proyecto, fue la metodología APRA (Acceso, Permanencia y Rendimiento Académico, que es una propuesta de intervención que considera los elementos fundamentales que apoyan los procesos sistemáticos de cambio y mejora institucional. La estrategia de trabajo transversal empleada durante la intervención fue la narrativa, apoyada de otras estrategias, como el cuaderno docente, la narración de experiencias docentes, el trabajo colegiado con retroalimentación grupal y la autoevaluación.

  16. Secció Docent i problemes: "La enseñanza del diseño de experimentos en ingeniería: Algunas experiencias prácticas"

    OpenAIRE

    Peña, D.; Molina, C.; Cordero, M.

    1987-01-01

    Este trabajo presenta nuestras experiencias enseñando diseño de experimentos en una Escuela de Ingenieros. Un objetivo del curso ha sido proporcionar a los estudiantes experiencias en la investigación empírica mediante la realización de trabajos elegidos por ellos mismos. Se analiza el papel del diseño de experimentos en la formación estadística de científicos, y la importancia del proceso iterativo en el aprendizaje de cualquier investigación científica. Peer Reviewed

  17. Microvascular pericytes in healthy and diseased kidneys

    Science.gov (United States)

    Pan, Szu-Yu; Chang, Yu-Ting; Lin, Shuei-Liong

    2014-01-01

    Pericytes are interstitial mesenchymal cells found in many major organs. In the kidney, microvascular pericytes are defined anatomically as extensively branched, collagen-producing cells in close contact with endothelial cells. Although many molecular markers have been proposed, none of them can identify the pericytes with satisfactory specificity or sensitivity. The roles of microvascular pericytes in kidneys were poorly understood in the past. Recently, by using genetic lineage tracing to label collagen-producing cells or mesenchymal cells, the elusive characteristics of the pericytes have been illuminated. The purpose of this article is to review recent advances in the understanding of microvascular pericytes in the kidneys. In healthy kidney, the pericytes are found to take part in the maintenance of microvascular stability. Detachment of the pericytes from the microvasculature and loss of the close contact with endothelial cells have been observed during renal insult. Renal microvascular pericytes have been shown to be the major source of scar-forming myofibroblasts in fibrogenic kidney disease. Targeting the crosstalk between pericytes and neighboring endothelial cells or tubular epithelial cells may inhibit the pericyte–myofibroblast transition, prevent peritubular capillary rarefaction, and attenuate renal fibrosis. In addition, renal pericytes deserve attention for their potential to produce erythropoietin in healthy kidneys as pericytes stand in the front line, sensing the change of oxygenation and hemoglobin concentration. Further delineation of the mechanisms underlying the reduced erythropoietin production occurring during pericyte–myofibroblast transition may be promising for the development of new treatment strategies for anemia in chronic kidney disease. PMID:24465134

  18. La experiencia docente en un MOOC

    OpenAIRE

    Ramírez Montoya, María Soledad

    2013-01-01

    1. Objetivo de la conferencia; 2. Antecedentes de experiencias de cursos masivos; 3. Experiencia en un curso MOOC-Proyecto SINED-CLARISE para la educación a distancia; 4. Preparación para un curso MOOC en Coursera

  19. Graft microvascular disease in solid organ transplantation.

    Science.gov (United States)

    Jiang, Xinguo; Sung, Yon K; Tian, Wen; Qian, Jin; Semenza, Gregg L; Nicolls, Mark R

    2014-08-01

    Alloimmune inflammation damages the microvasculature of solid organ transplants during acute rejection. Although immunosuppressive drugs diminish the inflammatory response, they do not directly promote vascular repair. Repetitive microvascular injury with insufficient regeneration results in prolonged tissue hypoxia and fibrotic remodeling. While clinical studies show that a loss of the microvascular circulation precedes and may act as an initiating factor for the development of chronic rejection, preclinical studies demonstrate that improved microvascular perfusion during acute rejection delays and attenuates tissue fibrosis. Therefore, preservation of a functional microvasculature may represent an effective therapeutic strategy for preventing chronic rejection. Here, we review recent advances in our understanding of the role of the microvasculature in the long-term survival of transplanted solid organs. We also highlight microvessel-centered therapeutic strategies for prolonging the survival of solid organ transplants.

  20. ¿Metrópolis ingobernables? Experiencias europeas ¿Metrópolis ingobernables? Experiencias europeas

    Directory of Open Access Journals (Sweden)

    Christian Lefèvre

    2010-12-01

    Full Text Available Las áreas metropolitanas se han convertido en lugares en los que tienen lugar algunos de los mayores desafíos para el gobierno de nuestras sociedades (desigualdades sociales y territoriales, desarrollo económico, la diversidad étnica y cultural, la preservación del medio ambiente, etc.. Sin embargo, a pesar de su relevancia como espacios para el tratamiento de estos problemas, las áreas metropolitanas tienen grandes dificultades para transformarse en territorios políticos, es decir, para alcanzar un nivel de agente político suficiente (como actor colectivo para producir políticas adecuadas que aborden estos problemas y produzcan estrategias colectivas que orienten su desarrollo futuro. Para tratar este tema, este artículo se centrará en primer lugar en los principales obstáculos que les impiden alcanzar el nivel de actor político, que son comunes a la mayoría de los países europeos: la resistencia del Estado a otorgar a estos territorios las funciones y recursos adecuados en el proceso de descentralización y su preferencia por el reforzamiento de los niveles de gobierno existentes; la oposición de estos niveles de gobierno y la falta de apoyo de la sociedad civil (actores económicos y población. En un segundo apartado, este artículo presentará diferentes experiencias que han tenido lugar en la última década para superar estos obstáculos. Centrándose en la pacificación de las relaciones de poder a nivel metropolitano mediante conferencias, cartas y pactos metropolitanos y “políticas procedimentales” como la planificación estratégica, el autor considera que estas experiencias no parecen ofrecer potencialidades para la reducción del conflicto político entre actores y concluye con un tono pesimista sobre la gobernabilidad de las áreas metropolitanas.Metropolitan areas have become places where some of the major issues and stakes for the government of our societies are taking place (social and territorial

  1. Microvascular decompression for trigeminal neuralgia

    International Nuclear Information System (INIS)

    Khan, S.A.; Khan, B.; Khan, A.A.; Afridi, E.A.A.; Mehmood, S.; Muhammad, G.; Hussain, I.; Zadran, K.K.; Bhatti, S.N.

    2015-01-01

    Background: Trigeminal Neuralgia (TGN) is the most frequently diagnosed type of facial pain. In idiopathic type of TGN it is caused by the neuro-vascular conflict involving trigeminal nerve. Microvascular decompression (MVD) aims at addressing this basic pathology in the idiopathic type of TGN. This study was conducted to determine the outcome and complications of patients with idiopathic TGN undergoing MVD. Method: In a descriptive case series patients with idiopathic TGN undergoing MVD were included in consecutive manner. Patients were diagnosed on the basis of detailed history and clinical examination. Retromastoid approach with craniectomy was used to access cerebellopontine angle (CP-angle) and microsurgical decompression was done. Patients were followed up for 6 months. Results: A total of 53 patients underwent MVD with mean age of 51.6±4.2 years and male predominance. In majority of cases (58.4 percentage) both Maxillary and Mandibular divisions were involved. Per-operatively superior cerebellar artery (SCA) was causing the neuro-vascular conflict in 33 (62.2 percentage) of the cases, anterior inferior cerebellar artery (AICA) in 6 (11.3 percentage) cases, both CSA and AICA in 3 (5.6 percentage) cases, venous compressions in only 1 (1.8percentage) patient and thick arachnoid adhesions were seen in 10 (18.9 percentage) patients. Postoperatively, 33 (68 percentage) patients were pain free, in 14 (26.45 percentage) patients pain was significantly improved whereas in 3 (5.6 percentage) patients there was mild improvement in symptoms. Three (5.6 percentage) patients did not improve after the primary surgery. Cerebrospinal fluid (CSF) leak was encountered in 7 (13.2 percentage) patients post-operatively, 4 (7.5 percentage) patients developed wound infection and 1 (1.8 percentage) patient developed aseptic meningitis. Three (5.6 percentage) patients had transient VII nerve palsy while one patient developed permanent VII nerve palsy. Conclusion: MVD is a safe and

  2. Experiencia con el colgajo de Kirschbaum en secuelas de quemaduras cérvico-faciales

    Directory of Open Access Journals (Sweden)

    P. Rossell-Perry

    2014-06-01

    Full Text Available Presentamos nuestra experiencia con el colgajo de Kirschbaum (colgajo en charretera en la corrección de retracciones cicatriciales de la región cervical anterior y del tercio inferior de la cara. Llevamos a cabo un estudio retrospectivo sobre una serie de 63 pacientes con retracciones cicatriciales de la región cervical anterior y del tercio inferior facial, operados por el primer autor entre los años 1996 y 2012 dentro del marco de las campañas quirúrgicas desarrolladas a lo largo del país (Perú en las áreas geográficas con mayor necesidad de atención especializada. En todos los casos empleamos el colgajo en charretera tomado de la región lateral del cuello y de la región deltoidea. Evaluamos a los pacientes mediante el examen físico y la documentación fotográfica obtenida en los periodos pre y postoperatorio. Obtuvimos mejoría en diferentes grados de la limitación funcional de la región cervical y facial en todos los casos operados, con viabilidad total del colgajo en 59 casos (93,65 % y parcial en 4 casos (6,34 % . No hubo ningún caso de pérdida total. Las complicaciones recogidas fueron pocas, principalmente hematomas, 6 casos (9,52 % e infección, 2 casos (3,17 % . Las zonas donantes evolucionaron con cicatriz hipertrófica en 22 de los casos (34,92 % . En conclusión, nuestra experiencia con el uso de esta técnica quirúrgica ha demostrado ser de utilidad en el tratamiento de las secuelas de quemadura con retracción cicatricial cervical y facial, por lo que consideramos que el colgajo de Kirschbaum es seguro y tiene pocas complicaciones.

  3. Imagen y Arte: La Necesidad de la Experiencia por la Sensación

    Directory of Open Access Journals (Sweden)

    Donald Hugh de Barros Kerr Junior (Goy

    2016-02-01

    Full Text Available Muchos procedimientos utilizados en propuestas pedagógicas definen las artes visuales en el cotidiano de escuelas brasileras. Cuestionamos aquellos que, despotencializados, continúan afirmando un carácter meramente instrumental y utilitario del quehacer artístico. Comenzamos la discusión tomando procedimientos que acaban confirmando que la imagen en la escuela, en gran parte, es tratada como ilustración y no como productora de pensamiento. Preguntamos: ¿qué alternativas pueden ser erguidas en el sentido de actualizar el uso de la imagen artística en el salón de clase? ¿Cómo huir de los estereotipos y modelos? Nos fundamentamos en los conceptos de experiencia y de arte como sensación. Con el concepto e heterotopía provocamos la percepción de algo que puede romper la sintaxis y presentarse por la sensación. Defendemos prácticas que hagan funcionar el arte como sensación y no a través de un lenguaje que fija y codifica lo no codificable de la experiencia artística. La sensación puede romper también con una formación docente apegada a rótulos, modelos y modismos. Abriéndonos al no cliché, nuevas formas de pensar y sentir, nos aproximan de los modos de crear propios del arte. Al dar continuidad a estos modos en nuestras vidas, repetimos en la diferencia rompiendo con aquellos procesos tan gobernados y lineales que se empeñan obstinadamente en permanecer en nuestra cotidianidad.

  4. Virtualización de las ecuaciones diferenciales: Una experiencia nueva.

    Directory of Open Access Journals (Sweden)

    Guerrero Manzano, Mª del Mar

    2004-01-01

    Full Text Available En estos últimos años venimos asistiendo a una gran proliferación del uso de las nuevas tecnologías en la enseñanza universitaria. Teniendo en cuenta que su utilización no es fácil, pero que hoy es una realidad en la Universidad, y cada vez con mayor importancia, un grupo de profesores nos hemos planteado cómo virtualizar una parte de la materia que normalmente impartimos con la asignatura de Matemáticas en los estudios de Economía y Empresa. Las peculiaridades de esta asignatura y las características propias, la hacen especialmente complicada en la enseñanza presencial, por ello parece lógico que nos apoyemos en la enseñanza virtual de la misma. La opción escogida ha sido la de impartir la parte de dinámica económica (Ecuaciones Diferenciales de nuestra asignatura♣ en un campus virtual, compartido entre nueve universidades españolas (Grupo 9 de Universidades. Se van a poner de manifiesto los resultados de nuestra experiencia, indicando tanto las ventajas como los inconvenientes con los que nos hemos encontrado.

  5. Microvascular Anastomosis Training in Neurosurgery: A Review

    Directory of Open Access Journals (Sweden)

    Vadim A. Byvaltsev

    2018-01-01

    Full Text Available Cerebrovascular diseases are among the most widespread diseases in the world, which largely determine the structure of morbidity and mortality rates. Microvascular anastomosis techniques are important for revascularization surgeries on brachiocephalic and carotid arteries and complex cerebral aneurysms and even during resection of brain tumors that obstruct major cerebral arteries. Training in microvascular surgery became even more difficult with less case exposure and growth of the use of endovascular techniques. In this text we will briefly discuss the history of microvascular surgery, review current literature on simulation models with the emphasis on their merits and shortcomings, and describe the views and opinions on the future of the microvascular training in neurosurgery. In “dry” microsurgical training, various models created from artificial materials that simulate biological tissues are used. The next stage in training more experienced surgeons is to work with nonliving tissue models. Microvascular training using live models is considered to be the most relevant due to presence of the blood flow. Training on laboratory animals has high indicators of face and constructive validity. One of the future directions in the development of microsurgical techniques is the use of robotic systems. Robotic systems may play a role in teaching future generations of microsurgeons. Modern technologies allow access to highly accurate learning environments that are extremely similar to real environment. Additionally, assessment of microsurgical skills should become a fundamental part of the current evaluation of competence within a microneurosurgical training program. Such an assessment tool could be utilized to ensure a constant level of surgical competence within the recertification process. It is important that this evaluation be based on validated models.

  6. Timectomía como tratamiento de miastenia gravis: Experiencia en el Hospital Nacional Dos de Mayo. Lima, Perú

    Directory of Open Access Journals (Sweden)

    Julio VASQUEZ KOBASHIGAWA

    2006-10-01

    Full Text Available La timectomía es una opción terapéutica en el manejo de la miastenia gravis (MG. Aunque existe controversia sobre las indicaciones quirúrgicas y el mejor momento para operar, la timectomía se mantiene como un procedimiento seguro y efectivo para el tratamiento de MG. Aquí revisamos nuestra experiencia con esta operación en pacientes con esta enfermedad, y comparamos nuestros resultados con aquellos publicados en la literatura.

  7. La Formación del profesor en NTIC como reto en el contexto de la convergencia europea. La Experiencia de la Universidad de Murcia

    Directory of Open Access Journals (Sweden)

    Mª Paz PRENDES ESPINOSA

    2005-01-01

    Full Text Available El presente documento pretende mostrar la experiencia y la evolución de los programas de formación dirigidos al profesorado de la Universidad de Murcia en los últimos años, relacionados con la integración de nuevos canales de aprendizaje y las Nuevas Tecnologías aplicadas a los modelos de enseñanza. Todo ello desde la perspectiva de la apuesta común europea y en el marco de las medidas que, a este respecto, se están tomando desde nuestra universidad.

  8. NUESTRA AMÉRICA COMO PLATAFORMA DE LA EDUCACIÓN EN EL CONTINENTE

    Directory of Open Access Journals (Sweden)

    Elmys Escribano Hervis

    2012-01-01

    Full Text Available En enero de 1891 José Martí publicó el ensayo "Nuestra América", obra esencial de su prosa. Se establece como hipótesis que esta obra es poseedora de una notable significación para la educación y la cultura en Latinoamérica. El objetivo de este trabajo es valorar el ensayo de referencia en estrecha relación con el contexto histórico social que lo condicionó y en consonancia con la integralidad del discurso de su autor. La metodología empleada se sustenta en la revisión, análisis e interpretación de las fuentes bibliográficas disponibles, en este caso la totalidad de la obra escrita de José Martí, ubicada en la edición de 1963, organizadas en 28 tomos. Se trabajó con la edición crítica de este ensayo editada en el año 2000 sobre la base de la investigación y las notas aportadas por CintioVitier. Se concluye que la concepción y escritura de Nuestra América a fines de la penúltima década del siglo XIX, es un hito esencial para el estudio del desarrollo histórico de la educación y la cultura latinoamericanas. Nuestra América convida a hacer causa común con los oprimidos y conceptualiza en el mestizaje, la esencialidad de nuestra cultura. Concibe la educación del hombre natural de América en acomodo con la Naturaleza, con la cultura, con su tiempo y aspiraciones de libertad y desarrollo de nuestras naciones. Es un discurso auténtico y coherente que favorece la determinación de referentes culturales necesarios para la educación del hombre latinoamericano.

  9. Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

    International Nuclear Information System (INIS)

    Gutiérrez-Barrios, Alejandro; Camacho-Jurado, Francisco; Díaz-Retamino, Enrique; Gamaza-Chulián, Sergio; Agarrado-Luna, Antonio; Oneto-Otero, Jesús; Del Rio-Lechuga, Ana; Benezet-Mazuecos, Javier

    2015-01-01

    Summary: We present a review of microvascular dysfunction in hypertrophic cardiomyopathy (HCM) and an interesting case of a symptomatic familial HCM patient with inducible ischemia by single photon emission computed tomography. Coronary angiography revealed normal epicardial arteries. Pressure wire measurements of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) demonstrated a significant microcirculatory dysfunction. This is the first such case that documents this abnormality invasively using the IMR. The measurement of IMR, a novel marker of microcirculatory dysfunction, provides novel insights into the pathophysiology of this condition. - Highlights: • Microvascular dysfunction is a common feature in hypertrophic cardiomyopathy (HCM) and represents a strong predictor of unfavorable outcome and cardiovascular mortality. • The index of microvascular resistance (IMR) is a new method for invasively assessing the state of the coronary microcirculation using a single pressure-temperature sensor-tipped coronary wire. • However assessment of IMR in HCM has not been previously reported. We report a case in which microvascular dysfunction is assessed by IMR. This index may be useful in future researches of HCM.

  10. Invasive assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: the index of microvascular resistance

    Energy Technology Data Exchange (ETDEWEB)

    Gutiérrez-Barrios, Alejandro, E-mail: aleklos@hotmail.com [Cardiology Department, Jerez Hospital, Jerez (Spain); Camacho-Jurado, Francisco [Cardiology Department, Punta Europa Hospital, Algeciras (Spain); Díaz-Retamino, Enrique; Gamaza-Chulián, Sergio; Agarrado-Luna, Antonio; Oneto-Otero, Jesús; Del Rio-Lechuga, Ana; Benezet-Mazuecos, Javier [Cardiology Department, Jerez Hospital, Jerez (Spain)

    2015-10-15

    Summary: We present a review of microvascular dysfunction in hypertrophic cardiomyopathy (HCM) and an interesting case of a symptomatic familial HCM patient with inducible ischemia by single photon emission computed tomography. Coronary angiography revealed normal epicardial arteries. Pressure wire measurements of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) demonstrated a significant microcirculatory dysfunction. This is the first such case that documents this abnormality invasively using the IMR. The measurement of IMR, a novel marker of microcirculatory dysfunction, provides novel insights into the pathophysiology of this condition. - Highlights: • Microvascular dysfunction is a common feature in hypertrophic cardiomyopathy (HCM) and represents a strong predictor of unfavorable outcome and cardiovascular mortality. • The index of microvascular resistance (IMR) is a new method for invasively assessing the state of the coronary microcirculation using a single pressure-temperature sensor-tipped coronary wire. • However assessment of IMR in HCM has not been previously reported. We report a case in which microvascular dysfunction is assessed by IMR. This index may be useful in future researches of HCM.

  11. Microvascular lesions of the true vocal fold.

    Science.gov (United States)

    Postma, G N; Courey, M S; Ossoff, R H

    1998-06-01

    Microvascular lesions, also called varices or capillary ectasias, in contrast to vocal fold polyps with telangiectatic vessels, are relatively small lesions arising from the microcirculation of the vocal fold. Varices are most commonly seen in female professional vocalists and may be secondary to repetitive trauma, hormonal variations, or repeated inflammation. Microvascular lesions may either be asymptomatic or cause frank dysphonia by interrupting the normal vibratory pattern, mass, or closure of the vocal folds. They may also lead to vocal fold hemorrhage, scarring, or polyp formation. Laryngovideostroboscopy is the key in determining the functional significance of vocal fold varices. Management of patients with a varix includes medical therapy, speech therapy, and occasionally surgical vaporization. Indications for surgery are recurrent hemorrhage, enlargement of the varix, development of a mass in conjunction with the varix or hemorrhage, and unacceptable dysphonia after maximal medical and speech therapy due to a functionally significant varix.

  12. Diagnóstico ultrasonográfico de malformaciones congénitas: Nuestra experiencia en el período 1983-1995

    OpenAIRE

    Pérez Ramírez, Miguel; Mulet Matos, Eusebio; Hartmann Guilarte, Armando

    1997-01-01

    Se hizo un resumen del trabajo realizado durante 13 años con ecografía bidimensional en el Departamento de ultrasonido de nuestro hospital, motivados por la importancia de la detección intraútero, cada vez más precoz, de las malformaciones congénitas, con el propósito de demostrar el valor de la ecografía bidimensional para el diagnóstico de éstas. Revisamos los expedientes clínicos de las pacientes con malformaciones diagnosticadas y analizamos variables como: positividad del diagnóstico, pr...

  13. Gestión de la información: Implementando las bases para la Investigación Científica desde nuestra experiencia

    Directory of Open Access Journals (Sweden)

    María Vallejos Atalaya

    2014-05-01

    Full Text Available The globalization of the economy and the level of technological development and communications have opened the borders of countries and knowledge, this social change is necessary to develop in students skills to participate in the information culture, in such a way that future generations possess skills and abilities to access, manage, integrate, evaluate, create and communicate information according to ethical principles. This paper aims to describe and analyze the experience of teachers in the Peruvian Union University, involved in a process of implementing powers to provide students the ability to manage information so that a reflective, autonomous and critical learning has required development of scientific research. The experience is to develop connections and interdisciplinary links between courses throughout the curriculum, making use of information technology and communication (ICT to support the learning process, reflection and collaboration across the educational environment. The results show the relationship between information management skills, research, learning and professional development processes

  14. Nuestra experiencia con el minivástago femoral de disco a compresión y el cotilo Hedrocel (tantalio)

    OpenAIRE

    Acosta Fle, José María; Alonso Barrio, José Antonio; Mencía Barrio, Ricardo; Fernández Hernández, O.; González Fernández, J.J.; Sánchez Herráez, S.

    2005-01-01

    Durante los años 2000 a 2002 intervinimos 18 pacientes de artrosis o necrosis sintomática de cadera, con minivástago de fijación metafisiaria de Disco a Compresión (Sulzer) y cotilo monobloque de tantalio Hedrocel (Zimmer), con par de fricción alúmina-polietileno. La edad media de los pacientes fue de 46,7 años (rango 35-61), y el seguimiento medio de 42 meses. La valoración clínica se realizó con la escala de Merle D'Augbigné Postel obteniendo 38,8% de resultados excelentes, 22,2 de resultad...

  15. Optimization of radiotherapeutic treatment with means scarcity: our two years experience; Optimizacion del tratamiento radioterapico con carestia de medios: nuestra experiencia de dos anios

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez M, S.; Carrera M, F.; Gomez-Millan B, J.; Bayo L, E.; Gutierrez B, L. [Hospital Juan Ramon Jimenez, Ronda Norte s/n, 21005 Huelva (Spain)

    1998-12-31

    The objectives of this work are to present solutions adopted with the purpose to improve the technical quality of our treatments. It is described the ICRU-50 nomenclature employed in our department, the application of the linear quadratic radiobiological model for the non conventional division into fractions calculations and some proposals from diverse localizations. It is described some techniques for treatments planning, as the use of modulator fields and mobile gaps with hemi-fields. Also it is described some contrivances utilized, such as the shoulders tensor in head and neck tumors. The radiotherapeutic treatment with few sources it is optimized with the personnel effort and the low costs. (Author)

  16. Efecto de la terapia hormonal de reemplazo sobre la mamografía: nuestra experiencia Effect of replacement hormone therapy on mammography: our experience in this field

    Directory of Open Access Journals (Sweden)

    Daysi Navarro Despaigne

    2005-12-01

    Full Text Available Se realizó un estudio retrospectivo, cuyo objetivo fue describir el efecto de la terapia hormonal de reemplazo (THR sobre las mamografías de mujeres de edad mediana que asistieron a la Clínica de Climaterio y Osteoporosis (ClimOs entre enero de 1998 y diciembre de 2003. A cada mujer se le realizó mamografía (Mx inicial y durante el uso de la THR, las cuales fueron informadas como: 1 mamografías sin alteraciones, 2 con cambios menores [densidad irregular y microcalcificaciones] y 3 con cambios mayores [nódulos, quistes u otra alteración]. Como tratamiento recibieron estrógenos solos (E, estrógenos y progestagenos combinados continuos (EP y terapia no estrogénica (fitoestrógenos, tibolona. La muestra estuvo constituida por 112 mujeres, con edades entre 34 y 59 años. La Mx inicial mostró: no alteraciones en el 85,5 %, cambios menores en el 9,1 y cambios mayores en el 5,4. En la posTHR (tiempo promedio entre ambos estudios: 2,5 años, el 66 % continuó con mamografías normales, en el 29,0 hubo cambios menores (pA retrospective study was conducted, with the objective of describing the effect of hormone replacement therapy (HRT on mammography performed on middle-aged females, who had been seen at climacterics and osteoporosis clinics from January 1998 to December 2003. Mammography had been performed on each woman at the beginning and during the use of the HRT, being the results as follows: 1 mammography showing no changes; 2 mammography with slight changes irregular density and microcalcification and 3 mammography with major changes nodules, cysts or any other change . As a treatment, they received estrogen (E, continuos combined estrogen and progestagen (EP and nonestrogen therapy (phytoestrogen, tibolone. The sample was composed of 112 women aged 34 to 59 years. The initial Mx showed no changes in 85,5 %, slight changes in 9,1 and major changes in 5,4 of females. After the application of HRT (average time between both mammographic studies of 2,5 years, 66 % of females continued showing no changes, 29 and 5 % had slight (p<0,05 and major changes respectively. Continuos combined therapy exhibited the highest frequency of changes. Those females without estrogen therapy showed no changes in mammography breast pattern. On balance, the results achieved in our context were comparable to those reported in other parts of the world about the effect of hormone replacement therapy on mammography breast density.

  17. Otitis maligna del diabético: nuestra experiencia y revisión de la literatura Malignant otitis of the diabetic: our experience and literature review

    Directory of Open Access Journals (Sweden)

    Pedro P. Morales Hechevarría

    2002-04-01

    Full Text Available Se realizó un estudio transversal en 22 diabéticos (18 tipo 2 y 4 tipo 1, mayores de 15 años, afectados de otitis maligna del diabético, para conocer las características clínicas y la evolución de estos pacientes. Se les confeccionó historia clínica completa (endocrinólogo y otológica minuciosa (otorrinolaringólogo. Se precisó la edad, sexo, tipo de tratamiento y tiempo de evolución de la DM, valores promedio de las glucemias, resultado del estudio bacteriológico de la secreción ótica, e imagenológico, así como síntomas y signos dependientes de esa otitis, complicaciones y resultado del tratamiento. Se empleó tratamiento insulínico intensivo y antibioticoterapia específica. La Pseudomona aeruginosa fue el germen causal más frecuente. La otalgia, el granuloma del conducto auditivo externo y el compromiso de los pares craneales (VII, IX y X fueron frecuentes. Se comprobó que más de la mitad de los pacientes egresaron mejorados o curados, no hubo fallecidos. Se observaron secuelas en 4 pacientes. Se presentó mayor frecuencia de OMD en los pacientes con DM tipo 2 con evolución mayor de 10 años. La causa más frecuente de indicación quirúrgica fue el granuloma del CAE. Se observaron las secuelas en 4 pacientes (18,2 %. Se concluyó que el diagnóstico precoz de la OMD, el tratamiento insulínico intensivo y una terapia con antibióticos adecuada puede disminuir significativamente la estadía hospitalaria, las secuelas y la mortalidad en estos pacientes.A cross-sectional study was conducted among 22 diabetics (18 type 2 and 4 type 1 over 15 that were affected by malignant otitis of the diabetic in order to know the clinical characteristics and evolution of these patients. A complete medical history (endocrinologist and a detailed otological history (ear, nose and throat specialist were made. Age, sex, type of treatment and time of evolution of diabetes mellitus, mean values of glycaemia, the result of the bacteriological study of otic secretion and of the imaging study, the symptoms and signs depending on that otitis, as well as the complications and the treatment outcome were determined. An intensive insulin treatment and a specific antibiotic therapy were used. The Pseudomona aeruginosa was the most common causal germ. Otalgia, the granuloma of the external auditory meatus and the compromise of the cranial pairs (VII, IX and X were frequent. It was proved that more than half of the patients were better or cured at discharge. There were no deaths. Sequelae were observed in 4 patients. The malignant otitis of the diabetic was more frequent in patients with type 2 DM with an evolution of more than 10 years. The most common cause of surgery indication was the granuloma of the EAM. Sequelae were observed in 4 patients (18.2 %. The early diagnosis of malignant otitis of the diabetic, the intensive insulin treatment and an adequate antibiotic therapy may produce a significant reduction of hospital stay, sequelae and mortality in these patients.

  18. Appendicular pseudodiverticula and acute appendicitis: Our 12-year experience Pseudodivertículos apendiculares y apendicitis aguda: Nuestra experiencia en 12 años

    Directory of Open Access Journals (Sweden)

    María del Carmen Manzanares-Campillo

    2011-11-01

    Full Text Available Introduction: the presence of diverticula and their complications in the cecal appendix is an uncommon disease. We present a series of 13 patients with this condition, and perform a review of the literature. Patients and method: we carried out a retrospective study of patients undergoing appendectomy for acute appendicitis in the last twelve years in our department. The pathological examination of these episodes revealed 13 cases with a diagnosis of diverticular disease, all of them consisting of pseudodiverticula. Their clinical manifestations, laboratory results, imaging tests, and histology were analyzed, and findings were compared to those in the previous literature. Results: the incidence of diverticular disease in our setting was 13 cases (0.8% among 1634 appendectomies for acute appendicitis. Diverticulitis was found in 8 patients (61.5%, and diverticulosis (38.5% in 5. Appendicular perforation was more common in patients with diverticular disease (53.8% as compared to those without this condition (31.1%. Conclusions: complicated diverticular disease in the vermiform appendix of adult patients may result in insidious, recurrent manifestations that may confound preoperative diagnosis. A higher risk for appendicular perforation renders appendectomy the therapy of choice, even prophylactically when the condition is incidentally identified preoperatively.Introducción: la presencia de divertículos y sus complicaciones en el apéndice cecal constituyen una entidad infrecuente. Presentamos una serie de 13 pacientes con esta patología y realizamos una revisión de la literatura. Pacientes y método: realizamos un estudio retrospectivo de los pacientes apendicectomizados por apendicitis aguda en los últimos doce años en nuestro servicio. El examen anatomopatológico de estos episodios reveló el diagnóstico de 13 casos con enfermedad diverticular, todos ellos pseudodivertículos. Se analizaron la clínica, pruebas analíticas, de imagen y la histología de los mismos, comparando los resultados con la literatura precedente. Resultados: la incidencia de enfermedad diverticular en nuestro medio fue de 13 casos (0,8% de 1634 apendicectomías realizadas por apendicitis aguda. En 8 pacientes se halló diverticulitis (61,5% y en 5 diverticulosis (38,5%. La perforación apendicular fue más frecuente en los pacientes con enfermedad diverticular (53,8% que en su ausencia (31,1%. Conclusiones: la enfermedad diverticular complicada en el apéndice vermiforme en pacientes de edad adulta puede originar una clínica insidiosa y recurrente, que dificulta el diagnóstico preoperatorio certero. El mayor riesgo de perforación apendicular relacionado con su presencia sitúa a la apendicectomía como el tratamiento de elección, incluso de forma profiláctica cuando su hallazgo intraoperatorio sea incidental.

  19. Microvascular Anastomosis: Proposition of a Learning Curve.

    Science.gov (United States)

    Mokhtari, Pooneh; Tayebi Meybodi, Ali; Benet, Arnau; Lawton, Michael T

    2018-04-14

    Learning to perform a microvascular anastomosis is one of the most difficult tasks in cerebrovascular surgery. Previous studies offer little regarding the optimal protocols to maximize learning efficiency. This failure stems mainly from lack of knowledge about the learning curve of this task. To delineate this learning curve and provide information about its various features including acquisition, improvement, consistency, stability, and recall. Five neurosurgeons with an average surgical experience history of 5 yr and without any experience in bypass surgery performed microscopic anastomosis on progressively smaller-caliber silastic tubes (Biomet, Palm Beach Gardens, Florida) during 24 consecutive sessions. After a 1-, 2-, and 8-wk retention interval, they performed recall test on 0.7-mm silastic tubes. The anastomoses were rated based on anastomosis patency and presence of any leaks. Improvement rate was faster during initial sessions compared to the final practice sessions. Performance decline was observed in the first session of working on a smaller-caliber tube. However, this rapidly improved during the following sessions of practice. Temporary plateaus were seen in certain segments of the curve. The retention interval between the acquisition and recall phase did not cause a regression to the prepractice performance level. Learning the fine motor task of microvascular anastomosis adapts to the basic rules of learning such as the "power law of practice." Our results also support the improvement of performance during consecutive sessions of practice. The objective evidence provided may help in developing optimized learning protocols for microvascular anastomosis.

  20. Radionuclide assessment of pulmonary microvascular permeability

    Energy Technology Data Exchange (ETDEWEB)

    Groeneveld, A.B.J. [Medical Intensive Care Unit, Department of Internal Medicine, Free University Hospital, De Boelelaan 1117, 1081 HV Amsterdam (Netherlands)

    1997-04-01

    The literature has been reviewed to evaluate the technique and clinical value of radionuclide measurements of microvascular permeability and oedema formation in the lungs. Methodology, modelling and interpretation vary widely among studies. Nevertheless, most studies agree on the fact that the measurement of permeability via pulmonary radioactivity measurements of intravenously injected radiolabelled proteins versus that in the blood pool, the so-called pulmonary protein transport rate (PTR), can assist the clinician in discriminating between permeability oedema of the lungs associated with the adult respiratory distress syndrome (ARDS) and oedema caused by an increased filtration pressure, for instance in the course of cardiac disease, i.e. pressure-induced pulmonary oedema. Some of the techniques used to measure PTR are also able to detect subclinical forms of lung microvascular injury not yet complicated by permeability oedema. This may occur after cardiopulmonary bypass and major vascular surgery, for instance. By paralleling the clinical severity and course of the ARDS, the PTR method may also serve as a tool to evaluate new therapies for the syndrome. Taken together, the currently available radionuclide methods, which are applicable at the bedside in the intensive care unit, may provide a gold standard for detecting minor and major forms of acute microvascular lung injury, and for evaluating the severity, course and response to treatment. (orig.). With 2 tabs.

  1. ¡La historia nuestra, Caballero! Turismo, invisibilidad y gentrificación

    OpenAIRE

    Garcés, Dedtmar

    2015-01-01

    El presente documento propone una lectura sobre la obra ¡La historia nuestra, Caballero! (Cartagena, 2008) del artista afrocartagenero Nelson Fory; para ello se vale de un registro audiovisual que permite contextualizar espacialmente la intervención. El texto, a través de la revisión de algunas fuentes, intenta argumentar la conexión que existe entre la declaración de la ciudad como Patrimonio Cultural de la Humanidad (1984), el enfoque que se le ha dado al tratamiento de su centro histórico,...

  2. Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad.

    OpenAIRE

    Reina de los Ángeles Carballé Piñón

    2015-01-01

    Este trabajo "Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad" resulta de la investigación realizada para tesis de maestría; se realizó el estudio de 2 entidades, nos permitió conocer las principales posiciones que sobre motivación existen, factores que la influencian, cómo incide en el desempeño laboral y que acciones diseñar para elevarla. Las 2 entidades seleccionadas, claves en el desempeño empresarial son un centro de interfase y un...

  3. Curso híbrido y de aula invertida apoyado en MOOC: experiencia de autoevaluación

    Directory of Open Access Journals (Sweden)

    Patricia Salinas Martínez

    2015-04-01

    Full Text Available Este escrito comparte elementos sobre el diseño e implementación del curso híbrido y aula invertida de “Introducción a las matemáticas universitarias”, apoyado en el curso MOOC “Matemáticas y movimiento” en Coursera. La experiencia se realizó en el segundo semestre de 2013 con ocho grupos escolares en una universidad prestigiosa del norte de México. El trabajo fuera del aula y en línea incluye el estudio de videos en preparación para las actividades presenciales en aula, en las que se profundiza en el aprendizaje que los videos promueven. La experiencia considera el trabajo colegiado entre los profesores durante el cual fueron tomadas decisiones a favor de indagar de manera sistemática las bondades de este tipo de formato innovador para el curso. Un estudio diagnóstico se efectúa para valorar varias dimensiones de la experiencia, entre ellas la evaluación, dimensión a la que se dedica este trabajo. La peculiaridad de haber integrado un proceso de autoevaluación por parte de los estudiantes para conformar su calificación del curso invita a la documentación de esta experiencia. Nuestra intención es incitar la reflexión académica acerca del proceso de evaluación ante los cambios de modalidad que se están gestando en la impartición de cursos universitarios.

  4. Marcos, horizontes visuales y experiencia del lugar

    Directory of Open Access Journals (Sweden)

    Enrique de Teresa

    2012-12-01

    Full Text Available

    Resumen

    "Habiendo educado mis ojos en el espectáculo de las cosas, intento deciros lo bello que he encontrado" Le Corbusier (El viaje de Oriente

    Desde la temprana fecha de 1911, en que realiza su viaje a Oriente, Le Corbusier nos muestra la capacidad mediadora que tiene la arquitectura para vincular los espacios, para conectar visualmente interior y exterior, para hacernos redescubrir la naturaleza acentuando nuestra percepción consciente. Sus dibujos sobre Villa Adriana, Pompeya, Atenas, etc., son un ejemplo de cómo percibir y plasmar en croquis su observación de la arquitectura y su ámbito exterior, de la captación del papel mediador entre arquitectura y lugar.
    En sus textos posteriores, y especialmente en "Vers une  architecture" (1923, así como a través de la experiencia de sus casas en los años veinte, nos mostrará el valor de las  operaciones que acotan, enmarcan y proporcionan una   dimensión de los espacios y del paisaje. Lo que hace de manera explícita y precisa en el texto "Une petite maison" (1923.
    Alvar Aalto y, posteriormente, Álvaro Siza, recogerán esta  capacidad de mediación entre arquitectura y lugar, buscando estimular la mirada para alentar la consciencia y el goce de los espacios y de la naturaleza. Las estrategias de la visión que  proponen, sobre todo en el último caso, lo llegan a  emparentar con el compromiso de enseñarnos a mirar y  experimentar del Land Art.
    Más allá de las imágenes expresivas y del lenguaje se tratará de ver, mediante ejemplos concretos, como la arquitectura se configura como vehículo de una percepción renovada y  alentadora de los espacios y del lugar.

    Palabras clave

    percepción, arquitectura, mediación, lugar, espacio

    Abstract

    "Having educated my eyes in the spectacle of things, I try to tell you what I have found beautiful." Le Corbusier (The

  5. El asunto del “Nuestra señora de la Mercedes” (Odyssey

    Directory of Open Access Journals (Sweden)

    F. Jesús Carrera Hernández

    2009-01-01

    Full Text Available Este trabajo constituye, básicamente, una valoración del informe emitido en Estados Unidos por el Juez Pizzo en el que ya podemos calificar como asunto del “Nuestra Señora de La Mercedes”, iniciado hace dos años tras las actividades de expolio desarrolladas por la empresa Odyssey en aguas del Atlántico próximas al Estrecho de Gibraltar. Se trata de un caso que afecta directamente a los intereses españoles en relación con el patrimonio cultural submarino situado en zonas próximas a nuestras costas. De convertirse en jurisprudencia, estaremos dando un paso más en aras de la protección del patrimonio cultural, soslayando la aplicación de legislaciones ancladas enla aplicación de principios de salvamento y hallazgos a bienes que poseen un valor arqueológico, histórico o cultural, y que se encuentran en santuarios de nuestros antepasados.

  6. NUESTRA PORTADA El deporte en la ciudad de Barcelona visto por una ilustradora

    Directory of Open Access Journals (Sweden)

    Ramon Balius i Juli

    2008-03-01

    Full Text Available Desde hace tiempo, en la revista Apunts elegimos y decidimos Nuestra Portada siguiendo la norma de dedicar las cuatro portadas correspondientes a un año a una temática similar. Así, hemos consagrado diferentes grupos de portadas a las obras deportivas de escultores o de pintores catalanes, a trabajos arquitectónicos de Gaudí, a distintos aspectos de la pluralidad de actividades de Leonardo da Vinci y, durante el último año, hemos presentado cuatro carteles de la colección del Biblioteca del Deporte. Por primera vez, Nuestra Portada ha sido encargada a una conocida y prestigiosa ilustradora que ha realizado un dibujo original destinado especialmente a la Monografía que publicamos sobre “El deporte en los espacios públicos urbanos”. Con esta decisión hemos seguido la definición de la Gran Enciclopedia Catalana que describe al ilustrador como “aquella persona que, basándose en el texto de una obra, escoge la ilustración más idónea para complementarla o enriquecerla”.

  7. La cooperación, una estrategia eficiente en el origen evolutivo de nuestra especie

    Directory of Open Access Journals (Sweden)

    Julia Sandra Bernal Crespo

    2012-01-01

    Full Text Available Este artículo propone la hipótesis de que la cooperación en forma de altruismo recíproco generalizado ejerció un papel esencial en el origen biosocial de nuestra especie. Al igual que en otras especies en que bajo condiciones adversas los individuos que se asociaron de forma permanente e incrementaron su eficacia biológica, en el origen de nuestra especie mamífera, primate y gregaria, los individuos con patrones de comportamiento de inversión parental, selección de parentesco y altruismo recíproco se coseleccionaron e incrementaron su eficacia biológica tanto a nivel individual como grupal. Propongo, además, que de las interacciones cooperativas reiteradas entre todos los individuos que son interdependientes surgió un patrón de organización social igualitario de estructuras simétricas, que resultó eficiente al conjugar los intereses individuales y colectivos, y que se mantuvo en equilibrio dinámico con mecanismos de regulación y control de aquellas conductas que pudieron desestabilizar el orden social.

  8. Treatment of Angina and Microvascular Coronary Dysfunction

    Science.gov (United States)

    Samim, Arang; Nugent, Lynn; Mehta, Puja K.; Shufelt, Chrisandra; Merz, C. Noel Bairey

    2014-01-01

    Opinion statement Microvascular coronary dysfunction (MCD) is an increasingly recognized cause of cardiac ischemia and angina, more commonly diagnosed in women. Patients with MCD present with the triad of persistent chest pain, ischemic changes on stress testing, and no obstructive coronary artery disease (CAD) on cardiac catheterization. Data from National Heart, Lung and Blood Institute (NHLBI)-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study has shown that the diagnosis of MCD is not benign, with a 2.5% annual risk of adverse cardiac events including myocardial infarction, stroke, congestive heart failure, or death. The gold standard diagnostic test for MCD is an invasive coronary reactivity test (CRT), which uses acetylcholine, adenosine, and nitroglycerin to test the endothelial dependent and independent, microvascular and macrovascular coronary function. The CRT allows for diagnostic and treatment options as well as further risk stratifying patients for future cardiovascular events. Treatment of angina and MCD should be aimed at ischemia disease management to reduce risk of adverse cardiac events, ameliorating symptoms to improve quality of life, and to decrease the morbidity from unnecessary and repeated cardiac catheterization in patients with open coronary arteries. A comprehensive treatment approach aimed at risk factor managment, including lifestyle counseling regarding smoking cessation, nutrition and physical activity should be initiated. Current pharmacotherapy for MCD can include the treatment of microvascular endothelial dysfunction (statins, angiotensin-converting enzyme inhibitor, low dose aspirin), as well as treatment for angina and myocardial ischemia (beta blockers, calcium channel blockers, nitrates, ranolazine). Additional symptom management techniques can include tri-cyclic medication, enhanced external counterpulsation, autogenic training, and spinal cord stimulation. While our current therapies are effective in the treatment

  9. Una experiencia del atletismo en Cantabria

    OpenAIRE

    Castillo Saornil, Santos

    2017-01-01

    Tesina titulada "Una experiencia del atletismo en Cantabria" del autor Santos Castillo Saornil y dirigida por el profesor Jesús Patricio Durán Piqueras. Instituto Nacional de Educación Física, curso 1983-1984. Consta de los siguientes capítulos: enseñanza del atletismo, iniciación al atletismo, la lección de iniciación al atletismo, iniciación a las carreras, experiencias personales, conclusiones y bibliografía.

  10. Aprendizaje Servicio. Una experiencia en Gobierno TI

    OpenAIRE

    García-Peñalvo, F. J.

    2017-01-01

    La conferencia “Aprendizaje Servicio. Una experiencia en Gobierno TI” fue impartida el día 16 de octubre de 2017 en la II Jornada: Aprendizaje Servicio y otras experiencias de innovación educativa en la UPM, dentro del Ciclo de Jornadas 2017. Tendencias en Innovación Educativa y su implantación en UPM. Presenta cómo se ha aplicado el aprendizaje-servicio en el contexto de la asignatura Gobierno de Tecnologías de la Información, del Máster en Ingeniería Informática de la Universidad ...

  11. Correlates of time to microvascular complications among diabetes ...

    African Journals Online (AJOL)

    Socio-demographic and clinical factors have been known to affect the time to microvascular complications and survival probabilities of diabetes mellitus patients. The objective of this study was to identify risk factors and estimate average survival times for the time to the development of microvascular complications of ...

  12. La Sociedad Española de Cirugía Plástica viaja a África: mi experiencia en Togo y Liberia

    Directory of Open Access Journals (Sweden)

    Elena Lorda-Barraguer

    Full Text Available En este artículo pretendo explicar mi experiencia en 5 campañas quirúrgicas en África. El último de estos viajes en noviembre de 2016 supuso el inicio de la cooperación internacional de la Sociedad Española de Cirugía Plástica, Reparadora y Estética en ese continente. También, dejar constancia de que es posible llevar a cabo una cirugía reconstructiva eficaz con recursos limitados si se cuenta con un buen apoyo logístico local. Y de lo necesaria que es nuestra cirugía capaz de mejorar la calidad de vida de muchos pacientes, lo que se pone de manifiesto incluso en estas expediciones sanitarias aunque sean de corta duración. Una vez registrada nuestra casuística, constatamos que los procesos patológicos intervenidos con más frecuencia son las secuelas de quemaduras, el labio leporino y las úlceras. Describo las condiciones de trabajo que hemos encontrado para facilitar futuras expediciones de otros colegas a quienes recomiendo encarecidamente esta experiencia.

  13. La experiencia de paro La experiencia de paro

    Directory of Open Access Journals (Sweden)

    Enric Sanchis

    2003-01-01

    las implicaciones del paro en contextos caracterizadas por la presencia o ausencia de dispositivos de protección social. Se concluye que los consecuencias no económicas del paro actual pueden ser tan graves como lo fueron durante la Gran Depresión. Dada la relevancia que algunos economistas atribuyen a los sistemas de protección del desempleo en la explicación del nivel y duración del paro europeo, en la segunda porte se analiza la teoría de la búsqueda de empleo y sus implicaciones para la política de mercado de trabajo a la luz de la literatura sobre la experiencia de paro. Se concluye que los recortes en los dispositivos de protección tienen, en el mejor de los casos, efectos positivos muy limitados sobre el paro y que podrían verse contrarrestados por efectos de signo contrario sobre las condiciones de trabajo, localidad de vida de los parados y el grado de cohesión social. En una situación coma la española habría que dar prioridad a las políticas activas de empleo, al tratamiento personalizado de los parados y a la persecución del fraude empresarial a la Seguridad Social

  14. Impaired coronary microvascular function in diabetics

    International Nuclear Information System (INIS)

    Tsujimoto, Go

    2000-01-01

    Global and regional myocardial uptake was determined with technetium-99m tetrofosmin and a 4 hour exercise (370 MBq iv) and rest (740 MBq iv) protocol, in 24 patients with non-insulin dependent diabetes mellitus and in 22 control subjects. The purpose of this study was to evaluate impaired coronary microvascular function in diabetics by measurement of % uptake increase in myocardial counts. The parameter of % uptake increase (ΔMTU) was calculated as the ratio of exercise counts to rest myocardial counts with correction of myocardial uptake for dose administered and physical decay between the exercise study and the rest study. Global ΔMTU was significantly lower in the diabetics than in control subjects (14.4±5.4% vs. 21.7±8.5%, p<0.01). Regional ΔMTU in each of 4 left ventricular regions (anterior, septal, inferior, posterolateral) was significantly lower in the diabetic group than in the control group (p<0.01) respectively, but there were no significant differences between ΔMTU in the 4 left ventricular regions in the same group. ΔMTU was useful as a non-invasive means of evaluating impaired coronary microvascular function in diabetics. (author)

  15. John Dewey: la experiencia estética como experiencia educativa

    Directory of Open Access Journals (Sweden)

    Diana Melisa Paredes Oviedo

    2010-02-01

    Full Text Available La experiencia estética se constituye en un elemento crucial para la obra de John Dewey. En primer lugar, este pensador recupera la idea de experiencia, en sentido amplio, referida a los procesos conscientes realizados por el ser humano. En segundo lugar, esta experiencia aparece como resultado de la interacción de los hombres con su entorno, de tal modo que se amplían las valoraciones que aquellos tienen acerca de éste. En tercer lugar, la experiencia tiene elementos analíticos y sintéticos que posibilitan cualificar los procesos cognitivos y cognoscitivos de los individuos. En cuarto lugar, la experiencia se clasifica de acuerdo a su función en intelectual, práctica y estética, siendo la última la más importante, en tanto que, se muestra como más universal y ampliada frente a las otras, y se comporta como experiencia educativa al ser la que cualifica de manera más profunda los juicios críticos que se hacen frente al mundo.Los anteriores aspectos serán trabajados en este artículo, con miras a explorar la universalidad de la experiencia estética deweyana y sus derivaciones en el campo de una propuesta educativa, en la que resulta de vital importancia la existencia de una experiencia común entre los diferentes grupos humanos para lograr configurar la inteligencia común que es la base para la educación en John Dewey.

  16. La experiencia brasileña

    OpenAIRE

    Barbosa, Phidias

    2011-01-01

    16 transparencias.-- Presentado en: Tercer Seminario internacional TECMERIN "Televisión digital terrestre: confrontando las experiencias brasileña y española", celebrado del 18 al 20 de enero de 2011 en la Universidad Carlos III de Madrid

  17. Differentiation state determines neural effects on microvascular endothelial cells

    International Nuclear Information System (INIS)

    Muffley, Lara A.; Pan, Shin-Chen; Smith, Andria N.; Ga, Maricar; Hocking, Anne M.; Gibran, Nicole S.

    2012-01-01

    Growing evidence indicates that nerves and capillaries interact paracrinely in uninjured skin and cutaneous wounds. Although mature neurons are the predominant neural cell in the skin, neural progenitor cells have also been detected in uninjured adult skin. The aim of this study was to characterize differential paracrine effects of neural progenitor cells and mature sensory neurons on dermal microvascular endothelial cells. Our results suggest that neural progenitor cells and mature sensory neurons have unique secretory profiles and distinct effects on dermal microvascular endothelial cell proliferation, migration, and nitric oxide production. Neural progenitor cells and dorsal root ganglion neurons secrete different proteins related to angiogenesis. Specific to neural progenitor cells were dipeptidyl peptidase-4, IGFBP-2, pentraxin-3, serpin f1, TIMP-1, TIMP-4 and VEGF. In contrast, endostatin, FGF-1, MCP-1 and thrombospondin-2 were specific to dorsal root ganglion neurons. Microvascular endothelial cell proliferation was inhibited by dorsal root ganglion neurons but unaffected by neural progenitor cells. In contrast, microvascular endothelial cell migration in a scratch wound assay was inhibited by neural progenitor cells and unaffected by dorsal root ganglion neurons. In addition, nitric oxide production by microvascular endothelial cells was increased by dorsal root ganglion neurons but unaffected by neural progenitor cells. -- Highlights: ► Dorsal root ganglion neurons, not neural progenitor cells, regulate microvascular endothelial cell proliferation. ► Neural progenitor cells, not dorsal root ganglion neurons, regulate microvascular endothelial cell migration. ► Neural progenitor cells and dorsal root ganglion neurons do not effect microvascular endothelial tube formation. ► Dorsal root ganglion neurons, not neural progenitor cells, regulate microvascular endothelial cell production of nitric oxide. ► Neural progenitor cells and dorsal root

  18. Cobertura de grandes quemados con cultivo de queratinocitos: casuística de nuestra Unidad y protocolo de tratamiento Massive burn coverage with keratinocytes cultured: our casuistry and treatment protocol

    Directory of Open Access Journals (Sweden)

    I. González Alaña

    2012-09-01

    Full Text Available El paciente gran quemado sigue siendo hoy en día un difícil reto al que se enfrentan múltiples profesionales sanitarios. La elevada mortalidad de estos pacientes se justifica por la severa alteración del estado general que sufren, las múltiples complicaciones que se asocian y por la ausencia de piel válida para cubrir las quemaduras, como sucede en el caso de los quemados de gran extensión. Este último inconveniente se solventa de diferentes maneras, siendo una de las más importantes el cultivo de queratinocitos. En la Unidad de Quemados del Hospital Universitario de Cruces en Baracaldo (Vizcaya, España, iniciamos la aplicación de esta técnica en 2001, con una experiencia acumulada en esta década de 14 pacientes. El objetivo de este artículo es mostrar nuestro protocolo de aplicación del procedimiento para la cobertura de quemados extensos, los criterios de inclusión y la terapéutica pre y postaplicación de las láminas de queratinocitos que empleamos en nuestra Unidad. Así mismo, presentamos las características de los pacientes tratados y nuestra propia experiencia en la aplicación de esta técnica que, a pesar de lograr resultados cada vez más satisfactorios y ser en ocasiones la única alternativa para un paciente extensamente quemado, tiene todavía hoy en día tantos detractores.The severe burn patient continues being nowadays a difficult challenge which multiple sanitary professionals face. The high mortality of these patients justifies itself by the severe alteration of the general condition, the multiple complications that they suffer and the absence of skin for their coverage, as is the case of extensive burns. This last disadvantage is settled in different ways, being one of the most important the treatment with keratinocytes culture. In the Cruces Universitary Hospital Burn Unit in Baracaldo (Vizcaya, Spain, we began the clinical application of this technique in 2001, with a 14 patients accumulated experience in

  19. Mandibular reconstruction with composite microvascular tissue transfer

    International Nuclear Information System (INIS)

    Coleman, J.J. III; Wooden, W.A.

    1990-01-01

    Microvascular free tissue transfer has provided a variety of methods of restoring vascularized bone and soft tissue to difficult defects created by tumor resection and trauma. Over 7 years, 26 patients have undergone 28 free flaps for mandibular reconstruction, 15 for primary squamous cell carcinoma of the floor of the mouth or tongue, 7 for recurrent tumor, and 6 for other reasons [lymphangioma (1), infection (1), gunshot wound (1), and osteoradionecrosis (3)]. Primary reconstruction was performed in 19 cases and secondary in 9. All repairs were composite flaps including 12 scapula, 5 radial forearm, 3 fibula, 2 serratus, and 6 deep circumflex iliac artery. Mandibular defects included the symphysis alone (7), symphysis and body (5), symphysis-body-ramus condyle (2), body or ramus (13), and bilateral body (1). Fourteen patients had received prior radiotherapy to adjuvant or curative doses. Eight received postoperative radiotherapy. All patients had initially successful vascularized reconstruction by clinical examination (28) and positive radionuclide scan (22 of 22). Bony stability was achieved in 25 of 26 patients and oral continence in 24 of 26. One complete flap loss occurred at 14 days. Complications of some degree developed in 22 patients including partial skin necrosis (3), orocutaneous fistula (3), plate exposure (1), donor site infection (3), fracture of reconstruction (1), and fracture of the radius (1). Microvascular transfer of bone and soft tissue allows a reliable reconstruction--despite previous radiotherapy, infection, foreign body, or surgery--in almost every situation in which mandible and soft tissue are absent. Bony union, a healed wound, and reasonable function and appearance are likely despite early fistula, skin loss, or metal plate or bone exposure

  20. Mandibular reconstruction with composite microvascular tissue transfer

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, J.J. III; Wooden, W.A. (Emory Univ. School of Medicine, Atlanta, GA (USA))

    1990-10-01

    Microvascular free tissue transfer has provided a variety of methods of restoring vascularized bone and soft tissue to difficult defects created by tumor resection and trauma. Over 7 years, 26 patients have undergone 28 free flaps for mandibular reconstruction, 15 for primary squamous cell carcinoma of the floor of the mouth or tongue, 7 for recurrent tumor, and 6 for other reasons (lymphangioma (1), infection (1), gunshot wound (1), and osteoradionecrosis (3)). Primary reconstruction was performed in 19 cases and secondary in 9. All repairs were composite flaps including 12 scapula, 5 radial forearm, 3 fibula, 2 serratus, and 6 deep circumflex iliac artery. Mandibular defects included the symphysis alone (7), symphysis and body (5), symphysis-body-ramus condyle (2), body or ramus (13), and bilateral body (1). Fourteen patients had received prior radiotherapy to adjuvant or curative doses. Eight received postoperative radiotherapy. All patients had initially successful vascularized reconstruction by clinical examination (28) and positive radionuclide scan (22 of 22). Bony stability was achieved in 25 of 26 patients and oral continence in 24 of 26. One complete flap loss occurred at 14 days. Complications of some degree developed in 22 patients including partial skin necrosis (3), orocutaneous fistula (3), plate exposure (1), donor site infection (3), fracture of reconstruction (1), and fracture of the radius (1). Microvascular transfer of bone and soft tissue allows a reliable reconstruction--despite previous radiotherapy, infection, foreign body, or surgery--in almost every situation in which mandible and soft tissue are absent. Bony union, a healed wound, and reasonable function and appearance are likely despite early fistula, skin loss, or metal plate or bone exposure.

  1. La formación inicial del profesorado de educación infantil: El análisis de materiales como experiencia reflexiva sobre la práctica educativa

    OpenAIRE

    Domínguez Domínguez, Consuelo

    1999-01-01

    El trabajo que presentamos analiza una experiencia sobre el análisis de los materiales didácticos utilizados en las escuelas de Educación Infantil de algunos centros de nuestra comunidad. Ha sido realizada por los alumnos de Magisterio de esta especialidad en su período de formación inicial, desde el ámbito de la Didáctica de las Ciencias Sociales y desde una perspectiva reflexiva y crítica de la enseñanza

  2. Emociones, agencia y experiencia escolar: el papel de los vínculos en los procesos de inclusión escolar en el nivel secundario

    Directory of Open Access Journals (Sweden)

    Mariana Nobile

    2014-04-01

    Full Text Available Desde hace unos años venimos explorando el modo en que la dimensión emocional de la experiencia escolar interviene en los procesos de inclusión-exclusión educativa en el nivelsecundario. Aquí analizamos en profundidad las entrevistas realizadas a 16 jóvenes de sectores populares que han egresado de las llamadas “Escuelas de Reingreso” en las que se indagaron las formas en que ellos enunciaban su experiencia emocional, explorando lasfuentes de dicha emocionalidad. Respeto, entusiasmo y tranquilidad fueron lasformas enunciativas utilizadas para describir sus experiencias. Nuestra hipótesis es que el tipo de vínculos construidos con los docentes en el marco de un formato escolar particular genera una emocionalidad positiva, que permite resignificar la trayectoria escolar personal, reposicionarse frente a la institución escolar y potenciar su sensación de agencia, en términos de sentirse con mayores márgenes de control acerca de su propia vida, permitiéndole de este modo desplegar diferentes tipos de estrategias personales para su integración laboral, educativa y familiar.

  3. Las franjas electorales en la experiencia chilena

    OpenAIRE

    Juan Ignacio García Rodríguez

    2013-01-01

    Expone la experiencia chilena sobre el establecimiento y regulación de las franjas electorales, para lo cual analiza la constitucionalidad de la franja, los principios involucrados, las disposiciones regulatorias, el papel del Consejo Nacional de Televisión, la jurisprudencia que sobre el tema ha sido emitida por el Tribunal Calificador de Elecciones y los retos que el sistema de franjas electorales enfrenta a futuro como lo es su aplicación a las elecciones primarias de los pa...

  4. Renal microvascular disease in an aging population: a reversible process?

    Science.gov (United States)

    Futrakul, Narisa; Futrakul, Prasit

    2008-01-01

    Renal microvascular disease and tubulointerstitial fibrosis are usually demonstrated in aging in humans and animals. It has recently been proposed that renal microvascular disease is the crucial determinant of tubulointerstitial disease or fibrosis. Enhanced circulating endothelial cell loss is a biomarker that reflects glomerular endothelial injury or renal microvascular disease, and fractional excretion of magnesium (FE Mg) is a sensitive biomarker that reflects an early stage of tubulointerstitial fibrosis. In aging in humans, both of these biomarkers are abnormally elevated. In addition, a glomerular endothelial dysfunction determined by altered hemodynamics associated with peritubular capillary flow reduction is substantiated. A correction of such hemodynamic alteration with vasodilators can effectively improve renal perfusion and restore renal function. Thus, anti-aging therapy can reverse the renal microvascular disease and dysfunction associated with the aging process.

  5. Buscando leer la historia mundial desde Nuestra América

    Directory of Open Access Journals (Sweden)

    Hernán G. H. Taboada

    2014-01-01

    Full Text Available Existen en América Latina muchos y ya tradicionales reclamos por el abandono del eurocentrismo historiográfico, y en algún grado se han alcanzado resultados en cuanto a los discursos nacionales y regionales se refiere. Sin embargo, seguimos siendo deudores de la vieja historia “universal” originada en Europa, con su exponente clave que es Hegel pero también una difusión capilar en los libros escolares, enciclopedias y toda obra de vulgarización. Esta persistencia se debe a la hegemonía cultural de los grupos criollos en América Latina, que tienen una muy peculiar relación con Europa y su cultura. Su visión histórica, que hemos denominado “eurocriollismo”, sigue predominando mientras en la misma Europa ya ha sido desplazada. Las propuestas para una historia “mundial” policéntrica, que ya tienen varias décadas en otros países, apenas son conocidas en América Latina. El artículo aspira a definir brevemente dicha historia universal eurocriolla, a presentar brevemente las corrientes de la historia mundial, a criticar algunas lecturas supuestamente alternativas desde Nuestra América (Leopoldo Zea, Enrique Dussel y a señalar el camino que falta recorrer. In Latin America, there are now many traditional protests of the abandonment of historiographical eurocentrism which, to some degree, have achieved national and regional discourse. However, we continue to be indebted to the old “universal” history originated in Europe. It’s key proponent is Hegel, but also the capillary diffusion of school books, encyclopedias, and other vulgar works. This persistence is due to a cultural hegemony of Creole groups in Latin America that have a very particular relationship with Europe and its culture. Their historical vision, which we have denominated “eurocriolism,” continues to dominate, while it has been displaced in Europe itself. The proposals for a polycentric world history which now has been in other countries for decades

  6. Engineering Microvascularized 3D Tissue Using Alginate-Chitosan Microcapsules

    OpenAIRE

    Zhang, Wujie; Choi, Jung K.; He, Xiaoming

    2017-01-01

    Construction of vascularized tissues is one of the major challenges of tissue engineering. The goal of this study was to engineer 3D microvascular tissues by incorporating the HUVEC-CS cells with a collagen/alginate-chitosan (AC) microcapsule scaffold. In the presence of AC microcapsules, a 3D vascular-like network was clearly observable. The results indicated the importance of AC microcapsules in engineering microvascular tissues -- providing support and guiding alignment of HUVEC-CS cells. ...

  7. Expresión de la sexualidad e inteligencia emocional: una experiencia educativa para reflexionar

    Directory of Open Access Journals (Sweden)

    Sonia Carballo-Vargas

    2004-09-01

    Full Text Available Esta experiencia trata sobre un curso taller de educación de la expresión de la sexualidad y de la inteligencia emocional, que se vivió en la Escuela Corazón de María, ubicada dentro del centro Penitenciario que alberga a jóvenes privados de libertad. El reto de liberar el poder constructivo que existe dentro de cada persona es posible sólo mediante la educación que permita admitir la verdad que hay en las concepciones ajenas, elaborar las propias y tener criterio independiente para construir y reconstruir posiciones y actuar con congruencia. El proceso educativo no ha concluido, pero se tiene esperanzas en estos adolescentes, que aunque son como los de nuestras familias, son tan únicos en su personalidad y en las oportunidades que les ha brindado la vida, que no se parecen a ninguno de los y las adolescentes quienes continuamente nos rodean.

  8. ENCUENTROS, NARRATIVAS Y EXPERIENCIAS CON JÓVENES DESVINCULADOS DEL CONFLICTO ARMADO COLOMBIANO

    Directory of Open Access Journals (Sweden)

    Lucas Marín Aponte

    2015-12-01

    Full Text Available El presente texto nos aproxima a la compresión de experiencias y desafíos que viven los jóvenes desvinculados de diferentes grupos armados, luego de egresar de los programas de atención a víctimas, en su proceso de reintegración a la vida civil. A través de diversos encuentros, se propiciaron espacios de diálogos que permitieron conocer sus testimonios, con el objetivo de implementar estrategias pedagógicas para atender estas poblaciones, y ahondar en nuestra realidad nacional. El reclutamiento forzado de menores, es un fenómeno social de impacto internacional que ha motivado múltiples estudios en especial desde las ciencias sociales, este fenómeno se presenta con mayor frecuencia en zonas rurales marginadas por el Estado, dominadas por estados paralelos o repúblicas independientes, dedicadas a actividades ilícitas. Hemos visto la necesidad de promover la creación de redes de apoyo institucionales y comunitarias que fortalezcan dichos procesos de reinserción ante un eventual acuerdo de paz en Colombia.

  9. Sensibilidad y pobreza, entre experiencias y prácticas clasistas

    Directory of Open Access Journals (Sweden)

    Emilio José Seveso Zanin

    2012-08-01

    Full Text Available Apelando a las relaciones de proximidad y distancia, cercanía y apertura, que se enuncia en la experiencia de clase, en este artículo avanzamos sobre la sensibilidad que expresan los sectores de clase media sobre la pobreza. Para ello, proponemos evaluar las percepciones y emociones de los vecinos de la ciudad de San Luis (Argentina sobre los sujetos asistidos por el “Programa de Seguridad Pública y Protección Civil”, privilegiando una comprensión de las formas del mirar en tanto práctica, arquitecta y a la vez expresión de las arquitecturas del mundo. Para ello retomamos el registro de entrevistas en profundidad realizado en ocasión de nuestra investigación doctoral. En primer lugar, mostraremos que más allá de los diferentes relatos existentes, prevalece una convergencia conformada por la propiedad del sentir clasista común. En un segundo momento, apreciamos las relaciones que aquella concierta en sus efectos. Partiendo de este modo de una inquietud que ha buscado dar cuenta del “qué se percibe” y del “qué se siente” en relación a los sujetos asistidos, se nos plantea la doble tarea de centrar la perspectiva del mundo que asumen los sujetos y de evaluar sus posibles consecuencias de estructuración.

  10. Sensibilidad y pobreza, entre experiencias y prácticas clasistas

    Directory of Open Access Journals (Sweden)

    Emilio Seveso Zanin

    2012-08-01

    Full Text Available Apelando a las relaciones de proximidad y distancia, cercanía y apertura, que se enuncian en la experiencia cotidiana, en este artículo avanzamos sobre la sensibilidad que expresan los sectores de clase media sobre la pobreza. Para ello, proponemos evaluar las percepciones y emociones de los vecinos de la ciudad de San Luis (Argentina sobre los sujetos asistidos por el “Programa de Seguridad Pública y Protección Civil”, privilegiando una comprensión de las formas del mirar en tanto práctica, arquitecta y a la vez expresión de las arquitecturas del mundo. Para ello retomamos el registro de entrevistas en profundidad que realizamos en ocasión de nuestra investigación doctoral. En primer lugar, mostraremos que más allá de los diferentes relatos existentes, prevalece una convergencia conformada por la propiedad común del sentir clasista. En un segundo momento, apreciamos las relaciones que esta última concierta en sus efectos. Partiendo de este modo de una inquietud que ha buscado dar cuenta del “qué se percibe” y del “qué se siente”, se nos plantea la doble tarea de centrar la perspectiva del mundo de los sujetos y de evaluar sus posibles consecuencias de estructuración.

  11. Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad.

    Directory of Open Access Journals (Sweden)

    Reina de los Ángeles Carballé Piñón

    2015-12-01

    Full Text Available Este trabajo "Estrategia para elevar la motivación laboral; factor imprescindible para mejorar nuestra productividad" resulta de la investigación realizada para tesis de maestría; se realizó el estudio de 2 entidades, nos permitió conocer las principales posiciones que sobre motivación existen, factores que la influencian, cómo incide en el desempeño laboral y que acciones diseñar para elevarla. Las 2 entidades seleccionadas, claves en el desempeño empresarial son un centro de interfase y un centro generador de conocimientos, nuestro objetivo principal es sugerir propuestas que eleven la motivación de los trabajadores del CIGET(centro de interfase y la Universidad de Sancti Spíritus(centro generador de conocimientos por desempeñar una mejor labor y lograr así aumento de la eficacia, eficiencia y productividad; este se concreta específicamente en determinar qué factores ocasionan desmotivación en los trabajadores del CIGET y la Universidad, identificar aquellos factores que realmente motivan a estas personas, de manera individual como colectivamente y trazar una estrategia con el objetivo de elevar la motivación de los trabajadores hacia la actividad que realizan y dotar a estos de herramientas para la identificación de actitudes positivas o negativas en el ámbito laboral y cómo potenciarlas o minimizarlas según sea el caso.

  12. Ecuador: La experiencia de Radio Latacunga

    Directory of Open Access Journals (Sweden)

    David Silva

    2015-01-01

    Full Text Available En Latacunga - Ecuador es entrevistada Lucelly Villa, de la comunidad Hijas de San Pablo, "Hermanas Paulinas", ella es directora de la Radio y presidenta de la CORAPE (Coordinadora de Radios Populares y Educativas de Ecuador. En la entrevista comenta la experiencia de las emisoras en las zonas campesinas de la provincia cuya población indígena campesina esta geográficamente dispersa en la provincia de Cotopaxi. Habla de las dificultades y logros en once años de labor, informa de cómo funcionan las cabinas y la programación.

  13. Las franjas electorales en la experiencia chilena

    Directory of Open Access Journals (Sweden)

    Juan Ignacio García Rodríguez

    2013-07-01

    Full Text Available Expone la experiencia chilena sobre el establecimiento y regulación de las franjas electorales, para lo cual analiza la constitucionalidad de la franja, los principios involucrados, las disposiciones regulatorias, el papel del Consejo Nacional de Televisión, la jurisprudencia que sobre el tema ha sido emitida por el Tribunal Calificador de Elecciones y los retos que el sistema de franjas electorales enfrenta a futuro como lo es su aplicación a las elecciones primarias de los partidos políticos.

  14. "Nuestra América": José Martí ante la Razón Moderna

    OpenAIRE

    Pedro Pablo Rodríguez

    2015-01-01

    Este artículo es un acercamiento al difícil y singular diálogo con el pensamiento moderno y sus procedimientos del escritor, pensador y político cubano José Martí. La tesis es que el ideario de Martí expresó los intereses y la perspectiva de los pueblos de Hispanoamérica, a la que llamó Nuestra América, por oposición, según escribió ¿a la otra América, que no es nuestra¿. Plenamente consciente de que la identidad de la región se sustentaba en una cultura nueva, mestiza de lo aborigen y lo esp...

  15. Pilot study on microvascular anastomosis: performance and future educational prospects.

    Science.gov (United States)

    Berretti, G; Colletti, G; Parrinello, G; Iavarone, A; Vannucchi, P; Deganello, A

    2017-11-30

    The introduction of microvascular free flaps has revolutionised modern reconstructive surgery. Unfortunately, access to training opportunities at standardised training courses is limited and expensive. We designed a pilot study on microvascular anastomoses with the aim of verifying if a short course, easily reproducible, could transmit microvascular skills to participants; if the chosen pre-test was predictive of final performance; and if age could influence the outcome. A total of 30 participants (10 students, 10 residents and 10 surgeons) without any previous microvascular experience were instructed and tested during a single 3 to 5 hour course. The two microanastomoses evaluated were the first ever performed by each participant. More than the half of the cohort was able to produce both patent microanastomoses in less than 2 hours; two-thirds of the attempted microanastomoses were patent. The pretest predicted decent scores from poor performances with a sensitivity of 61.5%, specificity of 100%, positive predictive value of 100% and negative predictive value of 40%. Students and residents obtained significantly higher scores than surgeons. Since our course model is short, cost-effective and highly reproducible, it could be introduced and implemented anywhere as an educational prospect for preselecting young residents showing talent and natural predisposition and having ambitions towards microvascular reconstructive surgery. © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale.

  16. Brain microvascular function during cardiopulmonary bypass

    International Nuclear Information System (INIS)

    Sorensen, H.R.; Husum, B.; Waaben, J.; Andersen, K.; Andersen, L.I.; Gefke, K.; Kaarsen, A.L.; Gjedde, A.

    1987-01-01

    Emboli in the brain microvasculature may inhibit brain activity during cardiopulmonary bypass. Such hypothetical blockade, if confirmed, may be responsible for the reduction of cerebral metabolic rate for glucose observed in animals subjected to cardiopulmonary bypass. In previous studies of cerebral blood flow during bypass, brain microcirculation was not evaluated. In the present study in animals (pigs), reduction of the number of perfused capillaries was estimated by measurements of the capillary diffusion capacity for hydrophilic tracers of low permeability. Capillary diffusion capacity, cerebral blood flow, and cerebral metabolic rate for glucose were measured simultaneously by the integral method, different tracers being used with different circulation times. In eight animals subjected to normothermic cardiopulmonary bypass, and seven subjected to hypothermic bypass, cerebral blood flow, cerebral metabolic rate for glucose, and capillary diffusion capacity decreased significantly: cerebral blood flow from 63 to 43 ml/100 gm/min in normothermia and to 34 ml/100 gm/min in hypothermia and cerebral metabolic rate for glucose from 43.0 to 23.0 mumol/100 gm/min in normothermia and to 14.1 mumol/100 gm/min in hypothermia. The capillary diffusion capacity declined markedly from 0.15 to 0.03 ml/100 gm/min in normothermia but only to 0.08 ml/100 gm/min in hypothermia. We conclude that the decrease of cerebral metabolic rate for glucose during normothermic cardiopulmonary bypass is caused by interruption of blood flow through a part of the capillary bed, possibly by microemboli, and that cerebral blood flow is an inadequate indicator of capillary blood flow. Further studies must clarify why normal microvascular function appears to be preserved during hypothermic cardiopulmonary bypass

  17. una experiencia de intervención

    Directory of Open Access Journals (Sweden)

    Cecilia Villarreal Montoya

    2007-01-01

    Full Text Available El artículo resume la experiencia de intervención con una familia de la escuela de Villa Esperanza de Pavas. Se trata de un matrimonio con dificultades para disciplinar a sus tres hijos varones de ocho, seis, y cuatro años. En primer lugar, se exponen los principios teóricos y metodológicos, para luego mostrar la aplicación de ellos en el proceso vivido por la familia. Se aplica el modelo de intervención estructural, que busca que la misma familia logre realizar, paso a paso, los cambios requeridos en la dinámica y estructura familiar. En la situación específica de esta familia, se observa el fortalecimiento de la pareja como tal y como madre y padre en la medida que van logrando asumir la autoridad en forma compartida para disciplinar a los hijos. Al compartir esta experiencia, la autora pretende estimular a profesionales en Orientación a asumir el reto de considerar a las familias de la comunidad estudiantil, de las instituciones educativas donde laboran, como parte importante en el quehacer orientador.

  18. Gap filling of 3-D microvascular networks by tensor voting.

    Science.gov (United States)

    Risser, L; Plouraboue, F; Descombes, X

    2008-05-01

    We present a new algorithm which merges discontinuities in 3-D images of tubular structures presenting undesirable gaps. The application of the proposed method is mainly associated to large 3-D images of microvascular networks. In order to recover the real network topology, we need to fill the gaps between the closest discontinuous vessels. The algorithm presented in this paper aims at achieving this goal. This algorithm is based on the skeletonization of the segmented network followed by a tensor voting method. It permits to merge the most common kinds of discontinuities found in microvascular networks. It is robust, easy to use, and relatively fast. The microvascular network images were obtained using synchrotron tomography imaging at the European Synchrotron Radiation Facility. These images exhibit samples of intracortical networks. Representative results are illustrated.

  19. Free and microvascular bone grafting in the irradiated dog mandible

    International Nuclear Information System (INIS)

    Altobelli, D.E.; Lorente, C.A.; Handren, J.H. Jr.; Young, J.; Donoff, R.B.; May, J.W. Jr.

    1987-01-01

    Microvascular and free rib grafts were placed in 4.5 cm defects in an edentate mandibular body defect 18 to 28 days after completion of 50 Gy of irradiation from a 60 Co source. The animals were sacrificed from two to forty weeks postoperatively and evaluated clinically, radiographically, and histologically. There was a marked difference in the alveolar mucosal viability with the two grafts. Mucosal dehiscence was not observed over any of the microvascular grafts, but was present in seven-eighths of the free grafts. Union of the microvascular bone graft to the host bone occurred within six weeks. In contrast, after six weeks the free graft was sequestered in all the animals. An unexpected finding with both types of graft was the marked subperiosteal bone formation. This bone appeared to be derived from the host bed, stabilizing and bridging the defects bilaterally. The results suggest that radiated periosteum may play an important role in osteogenesis

  20. Active cooling of microvascular composites for battery packaging

    Science.gov (United States)

    Pety, Stephen J.; Chia, Patrick X. L.; Carrington, Stephen M.; White, Scott R.

    2017-10-01

    Batteries in electric vehicles (EVs) require a packaging system that provides both thermal regulation and crash protection. A novel packaging scheme is presented that uses active cooling of microvascular carbon fiber reinforced composites to accomplish this multifunctional objective. Microvascular carbon fiber/epoxy composite panels were fabricated and their cooling performance assessed over a range of thermal loads and experimental conditions. Tests were performed for different values of coolant flow rate, channel spacing, panel thermal conductivity, and applied heat flux. More efficient cooling occurs when the coolant flow rate is increased, channel spacing is reduced, and thermal conductivity of the host composite is increased. Computational fluid dynamics (CFD) simulations were also performed and correlate well with the experimental data. CFD simulations of a typical EV battery pack confirm that microvascular composite panels can adequately cool battery cells generating 500 W m-2 heat flux below 40 °C.

  1. Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment

    Directory of Open Access Journals (Sweden)

    Elizabeth P. Moran

    2015-01-01

    Full Text Available Peroxisome-proliferator activated receptor-alpha (PPARα is a broadly expressed nuclear hormone receptor and is a transcription factor for diverse target genes possessing a PPAR response element (PPRE in the promoter region. The PPRE is highly conserved, and PPARs thus regulate transcription of an extensive array of target genes involved in energy metabolism, vascular function, oxidative stress, inflammation, and many other biological processes. PPARα has potent protective effects against neuronal cell death and microvascular impairment, which have been attributed in part to its antioxidant and anti-inflammatory properties. Here we discuss PPARα’s effects in neurodegenerative and microvascular diseases and also recent clinical findings that identified therapeutic effects of a PPARα agonist in diabetic microvascular complications.

  2. De silencios, olvidos y memorias “invisibles”: el caso de las experiencias católicas “liberacionistas” en Rosario

    Directory of Open Access Journals (Sweden)

    López Tessore, Verónica

    2017-06-01

    Full Text Available En este artículo indago las relaciones entre memoria e identidad, específicamente en lo que refiere a los silencios, olvidos y a algunas memorias que caracterizo como “invisibles”, a partir de los testimonios obtenidos y las experiencias vividas a lo largo del trabajo de campo realizado para nuestra tesis doctoral en curso sobre las “memorias locales y construcción de identidades políticas en relación con las rupturas y continuidades dentro del catolicismo en Rosario desde los sesenta a la actualidad”. De este modo es que, en primer término, me detengo en ciertas precisiones teórico- conceptuales acerca de las relaciones entre memoria, historia e identidad conmi objeto de estudio en particular, para luego reflexionar sobre los distintos silencios que se fueron presentando en algunas de las entrevistas realizadas.

  3. Engineering Microvascularized 3D Tissue Using Alginate-Chitosan Microcapsules.

    Science.gov (United States)

    Zhang, Wujie; Choi, Jung K; He, Xiaoming

    2017-02-01

    Construction of vascularized tissues is one of the major challenges of tissue engineering. The goal of this study was to engineer 3D microvascular tissues by incorporating the HUVEC-CS cells with a collagen/alginate-chitosan (AC) microcapsule scaffold. In the presence of AC microcapsules, a 3D vascular-like network was clearly observable. The results indicated the importance of AC microcapsules in engineering microvascular tissues -- providing support and guiding alignment of HUVEC-CS cells. This approach provides an alternative and promising method for constructing vascularized tissues.

  4. Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?

    Directory of Open Access Journals (Sweden)

    Mary N. Rizk

    2013-01-01

    Conclusion Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications.

  5. Experiencia práctica: enseñanza del español como lengua extranjera en un centro educativo. Una mirada crítica

    Directory of Open Access Journals (Sweden)

    Juan Carlos Tordera Yllescas

    2012-01-01

    Full Text Available Nuestra experiencia se deriva de nuestra estancia en el I. E. S. Ausiàs March de (Manises. A este centro, en el que se imparten clases de educación secundaria y bachillerato, asisten alrededor de cuatrocientos alumnos. Entre estos alumnos, un gran índice de alumnado (alrededor de un nada desdeñable 5 % está representado por alumnos de países extranjeros que tienen un ajustado o bien escaso conocimiento del español. Si a este número, se suman los extranjeros con dominio del español, el número de alumnos extranjeros se incrementa considerablemente. De hecho, dada la tradición existente en este pueblo (que los alumnos extranjeros vayan al Ausiàs March, cabe decir que, de los tres centros educativos de enseñanzas secundarias de que dispone Manises, es en el Ausiàs March en el que se concentra el mayor número de extranjeros. Es más, este hecho es auspiciado por la misma administración municipal, ya que a los padres de los alumnos extranjeros que acuden al Ayuntamiento de Manises se les aconseja que matriculen a sus hijos en dicho centro.

  6. Los medios sociales a través de la experiencia web: un análisis de su percepción desde un enfoque relacional

    Directory of Open Access Journals (Sweden)

    José Ramón Sarmiento Guede

    2017-04-01

    Full Text Available La última década se ha caracterizado por la aparición de los Medios Sociales y su influencia en el desarrollo de la actitud y el comportamiento de los consumidores. Ante este contexto, el propósito de esta investigación es conocer en profundidad los diferentes tipos de Medios Sociales que se pueden encontrar en la Web 2.0 y estudiar cómo se utilizan y se perciben a través de la experiencia web. Metodológicamente, hemos procedido por una revisión de la bibliografía y hemos aplicado técnicas cuantitativas con el fin de analizar dicha percepción con base en una serie de variables. En definitiva, hemos podido identificar doce tipos de medios sociales y constatar que forman parte de nuestra vida y están transformando nuestras actitudes y comportamientos respecto de un producto, un servicio o una marca.

  7. Una experiencia lexicográfica

    Directory of Open Access Journals (Sweden)

    José Aldemar Álvarez Valencia

    2006-01-01

    Full Text Available Las dinámicas actuales de las sociedades modernas y postmodernas hacen que haya una constante creación y flujo de unidades léxicas cuyo origen se hace cada vez más difícil de identificar. Este documento se propone reportar una experiencia investigativa en el área de la lexicografía que se llevó a cabo en algunos pueblos de la región de Cundinamarca. A través de grabaciones de audio de conversaciones informales, entrevistas y cuestionarios se buscó elaborar un glosario de naturaleza dialectal. Las conclusiones indican que debido a la movilidad de los habitantes de la ciudad de Bogotá hacia los pueblos de Cundinamarca y viceversa, es difuso determinar un vocabulario específico.

  8. Experiencias y aprendizajes con juegos cooperativos

    Directory of Open Access Journals (Sweden)

    Evelyn Cerdas Agüero

    2013-03-01

    Full Text Available El presente trabajo tiene como objetivo presentar experiencias y aprendizajes que  han logrado algunos grupos de docentes con los que se ha trabajado por medio de talleres de juegos cooperativos para la paz. Los talleres se han facilitado desde la actividad de extensión Aula Activa: juegos cooperativos para la Educación para la Paz que se ha implementado en el  Instituto de Estudios Latinoamericanos (IDELA desde el 2006. En este trabajo  nos enfocamos en el trabajo con docentes del Ministerio de Educación Pública (MEP de Costa Rica, proceso que deja una serie de aprendizajes actitudinales, de valores, habilidades y cognocitivos.

  9. Microvascular imaging: techniques and opportunities for clinical physiological measurements

    International Nuclear Information System (INIS)

    Allen, John; Howell, Kevin

    2014-01-01

    The microvasculature presents a particular challenge in physiological measurement because the vessel structure is spatially inhomogeneous and perfusion can exhibit high variability over time. This review describes, with a clinical focus, the wide variety of methods now available for imaging of the microvasculature and their key applications. Laser Doppler perfusion imaging and laser speckle contrast imaging are established, commercially-available techniques for determining microvascular perfusion, with proven clinical utility for applications such as burn-depth assessment. Nailfold capillaroscopy is also commercially available, with significant published literature that supports its use for detecting microangiopathy secondary to specific connective tissue diseases in patients with Raynaud's phenomenon. Infrared thermography measures skin temperature and not perfusion directly, and it has only gained acceptance for some surgical and peripheral microvascular applications. Other emerging technologies including imaging photoplethysmography, optical coherence tomography, photoacoustic tomography, hyperspectral imaging, and tissue viability imaging are also described to show their potential as techniques that could become established tools for clinical microvascular assessment. Growing interest in the microcirculation has helped drive the rapid development in perfusion imaging of the microvessels, bringing exciting opportunities in microvascular research. (topical review)

  10. "Nuestra América": José Martí ante la Razón Moderna

    Directory of Open Access Journals (Sweden)

    Pedro Pablo Rodríguez

    2015-09-01

    Full Text Available Este artículo es un acercamiento al difícil y singular diálogo con el pensamiento moderno y sus procedimientos del escritor, pensador y político cubano José Martí. La tesis es que el ideario de Martí expresó los intereses y la perspectiva de los pueblos de Hispanoamérica, a la que llamó Nuestra América, por oposición, según escribió “a la otra América, que no es nuestra”. Plenamente consciente de que la identidad de la región se sustentaba en una cultura nueva, mestiza de lo aborigen y lo español, el cubano dedicó su ensayo “Nuestra América” a explicar los factores internos que mantenían las estructuras sociales, políticas y de pensamiento de la época colonial, así como el peligro que representaba el creciente poderío de Estados Unidos.   This article aims to approach Cuban writer, thinker and politician José Martí's harsh, singular dialogue with modern thinking and its procedures. It argues that Martí's set of ideas expressed the interests and viewpoint of the peoples of Hispanic America, which he called Our America, as opposed to, according to his own texts, "the other America, the one that is not ours". Fully conscious of the fact that the region's identity was based on a new culture, resulting from a mix of the indigenous and the Spanish, Martí used his essay "Our America" (originally, "Nuestra América" to explain the internal factors that maintained the colonial social, political and ideological structures, in addition to expressing the threat the growing power of the United States represented.

  11. Verocytotoxin-induced apoptosis of human microvascular endothelial cells.

    Science.gov (United States)

    Pijpers, A H; van Setten, P A; van den Heuvel, L P; Assmann, K J; Dijkman, H B; Pennings, A H; Monnens, L A; van Hinsbergh, V W

    2001-04-01

    The pathogenesis of the epidemic form of hemolytic uremic syndrome is characterized by endothelial cell damage. In this study, the role of apoptosis in verocytotoxin (VT)-mediated endothelial cell death in human glomerular microvascular endothelial cells (GMVEC), human umbilical vein endothelial cells, and foreskin microvascular endothelial cells (FMVEC) was investigated. VT induced apoptosis in GMVEC and human umbilical vein endothelial cells when the cells were prestimulated with the inflammatory mediator tumor necrosis factor-alpha (TNF-alpha). FMVEC displayed strong binding of VT and high susceptibility to VT under basal conditions, which made them suitable for the study of VT-induced apoptosis without TNF-alpha interference. On the basis of functional (flow cytometry and immunofluorescence microscopy using FITC-conjugated annexin V and propidium iodide), morphologic (transmission electron microscopy), and molecular (agarose gel electrophoresis of cellular DNA fragments) criteria, it was documented that VT induced programmed cell death in microvascular endothelial cells in a dose- and time-dependent manner. Furthermore, whereas partial inhibition of protein synthesis by VT was associated with a considerable number of apoptotic cells, comparable inhibition of protein synthesis by cycloheximide was not. This suggests that additional pathways, independent of protein synthesis inhibition, may be involved in VT-mediated apoptosis in microvascular endothelial cells. Specific inhibition of caspases by Ac-Asp-Glu-Val-Asp-CHO, but not by Ac-Tyr-Val-Ala-Asp-CHO, was accompanied by inhibition of VT-induced apoptosis in FMVEC and TNF-alpha-treated GMVEC. These data indicate that VT can induce apoptosis in human microvascular endothelial cells.

  12. Blood-based biomarkers of microvascular pathology in Alzheimer's disease.

    LENUS (Irish Health Repository)

    Ewers, Michael

    2012-02-01

    Sporadic Alzheimer\\'s disease (AD) is a genetically complex and chronically progressive neurodegenerative disorder with molecular mechanisms and neuropathologies centering around the amyloidogenic pathway, hyperphosphorylation and aggregation of tau protein, and neurofibrillary degeneration. While cerebrovascular changes have not been traditionally considered to be a central part of AD pathology, a growing body of evidence demonstrates that they may, in fact, be a characteristic feature of the AD brain as well. In particular, microvascular abnormalities within the brain have been associated with pathological AD hallmarks and may precede neurodegeneration. In vivo assessment of microvascular pathology provides a promising approach to develop useful biological markers for early detection and pathological characterization of AD. This review focuses on established blood-based biological marker candidates of microvascular pathology in AD. These candidates include plasma concentration of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) that are increased in AD. Measures of endothelial vasodilatory function including endothelin (ET-1), adrenomedullin (ADM), and atrial natriuretic peptide (ANP), as well as sphingolipids are significantly altered in mild AD or during the predementia stage of mild cognitive impairment (MCI), suggesting sensitivity of these biomarkers for early detection and diagnosis. In conclusion, the emerging clinical diagnostic evidence for the value of blood-based microvascular biomarkers in AD is promising, however, still requires validation in phase II and III diagnostic trials. Moreover, it is still unclear whether the described protein dysbalances are early or downstream pathological events and how the detected systemic microvascular alterations relate to cerebrovascular and neuronal pathologies in the AD brain.

  13. VIH e infecciones oportunistas: un tema de actualidad y motivo de interés en nuestra familia FELSOCEM.

    Directory of Open Access Journals (Sweden)

    Pedro Felipe Parra Velasco

    2010-08-01

    Full Text Available Me complace observar, la forma en que los estudiantes de medicina se concientizan de problemas grandes de nuestra sociedad, que impactan la salud en términos de mortalidad. Es el caso del VIH; referenciado en un artículo de la edición anterior; denominado “Infecciones oportunistas en individuos VIH hospitalizados. Hospital Vargas de Caracas. 2005 - 2006”, poniendo en manifiesto las infecciones oportunistas como factor determinante en la sobrevida de los pacientes que padecen esta enfermedad (...

  14. Lectura crítica: tres experiencias venezolanas

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    Adolfo Herrera E.

    2015-01-01

    Full Text Available Las tres experiencias seleccionadas tienen que ver con la difusión de mensajes, lo que las introduce en un mecanismo de amplio espectro informativo, y esto podría llamarse el ingrediente popular.

  15. Implementación de un modelo de evaluación en el área de Ciencias de la salud. Experiencia práctica en el máster en Gastronomía, cultura y salud

    OpenAIRE

    Morales Gómez, Patricia; Fernández Ruiz, Virginia; Sánchez Mata, Mª Cortes; Cámara Hurtado, Montaña

    2012-01-01

    El desarrollo e implementación de un sistema evaluativo en el marco del EEES, especialmente en entornos e-learning, si bien es una tarea compleja conlleva claros beneficios para el desarrollo de la docencia y la calidad de las decisiones que debemos tomar como profesores acerca del proceso de aprendizaje de nuestros alumnos. En el presente trabajo mostraremos los resultados obtenidos de nuestra experiencia práctica en la implantación del sistema de evaluación totalmente on-line, llevado a cab...

  16. Experiencia con Nexobrid® para el desbridamiento enzimático de quemaduras faciales seguido de tratamiento conservador con Medihoney®

    Directory of Open Access Journals (Sweden)

    José-Manuel Sampietro-De-Luis

    Full Text Available Introducción y Objetivos. El desbridamiento enzimático de las quemaduras ha sido objeto de estudio durante décadas; en este terreno, NexoBrid® (MediWound Ltd., Israel se postula como una prometedora alternativa al desbridamiento quirúrgico clásico. Por otra parte, las propiedades antibacterianas y promotoras de la cicatrización de la miel también se han evaluado recientemente con buenos resultados clínicos. Describimos nuestra experiencia preliminar con el empleo de NexoBrid® para el tratamiento de quemaduras faciales, seguido de curas tópicas con Medihoney® Wound Gel (Derma Sciences Ltd., EE.UU.. Material y Método. Incluimos en el estudio todos los pacientes atendidos en nuestra Unidad de Quemados con quemaduras faciales dérmicas o subdérmicas que afectaban a 2 o más subunidades estéticas. Realizamos desbridamiento enzimático con NexoBrid® en las primeras 24 horas. Posteriormente, llevamos a cabo tratamiento conservador con curas tópicas con Medihoney® Wound Gel. Recogimos todos los datos de calidad del desbridamiento, necesidad de desbridamiento quirúrgico, tiempo hasta epitelización completa, presencia de infección y necesidad de cirugía correctora de secuelas. Resultados. Tratamos 10 pacientes con quemaduras faciales de etiología diversa (llama, flash eléctrico, deflagración, escaldadura y química. El desbridamiento inicial fue completo en todos los pacientes. Se alcanzó la epitelización completa en una media de 13.88 días (10-20 días. Ningún paciente presentó infección clínicamente manifiesta ni precisó desbridamiento quirúrgico, cobertura mediante autoinjertos o cirugía de secuelas. Conclusiones. Nuestra experiencia preliminar indica que parece factible la aplicación de NexoBrid® y su combinación con Medihoney® para el tratamiento conservador de las quemaduras faciales.

  17. Vivenciando la experiencia de jóvenes con violencia familiar que viven en Hogares protegidos

    Directory of Open Access Journals (Sweden)

    María Julia Calvo-Gil

    Full Text Available El móvil del estudio de las vivencias de jóvenes con maltrato nace al identificar y establecer contacto con víctimas. Otro motivo del fenómeno fue que, no obstante ser un tema de diversas investigaciones y con el que convive día a día nuestra sociedad, es ineficiente el compromiso que adquiere cada ser social con esta problemática. El objetivo de la investigación fue comprender sus vivencias, sus experiencias de vida, cómo ellos perciben las causas que genera la situación y cómo la afrontan, para así ampliar la visión en la atención integral que realiza el profesional de Enfermería al identificar un caso de maltrato. Para el trabajo se utilizó la metodología cualitativa con enfoque fenomenológico, lo cual permitió obtener conocimientos sobre el fenómeno en estudio, lo que se logró a través del análisis de discursos obtenidos de forma voluntaria de jóvenes pertenecientes a un Hogar del Servicio Nacional de Menores (SENAME, Chile, a los cuales se les dio la confidencialidad en el manejo de información y de su identidad. Del análisis de los datos se obtuvieron los siguientes temas: Describiendo sentimientos de abandono; Negándose a asumir la situación de maltrato; Percibiendo el apoyo familiar; Postergando sus necesidades; Expresando rebeldía.

  18. Emociones, agencia y experiencia escolar: el papel de los vínculos en los procesos de inclusión escolar en el nivel secundario

    Directory of Open Access Journals (Sweden)

    Mariana Nobile

    2014-04-01

    Full Text Available Normal 0 false false false ES-TRAD JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin;} Desde hace unos años venimos explorando el modo en que la dimensión emocional de la experiencia escolar interviene en los procesos de inclusión-exclusión educativa en el nivel secundario. Aquí analizamos las entrevistas en profundidad realizadas a 16 jóvenes de sectores populares que han egresado de las llamadas “Escuelas de Reingreso” en las que se indagaron las formas en que enunciaban su experiencia emocional, explorando las fuentes de dicha emocionalidad. Respeto, entusiasmo y tranquilidad fueron las formas enunciativas utilizadas para describir sus experiencias. Nuestra hipótesis es que el tipo de vínculos construidos con los docentes en el marco de un formato escolar particular genera una emocionalidad positiva, que permite resignificar la trayectoria escolar personal, reposicionarse frente a la institución escolar y potenciar su sensación de agencia, en términos de sentirse con mayores márgenes de control acerca de su propia vida, permitiéndole de este modo desplegar diferentes tipos de estrategias personales para su integración laboral, educativa y familiar.

  19. Capacitación-acción participativa: una experiencia de 24 años en las comunidades rurales de Oaxaca, México.

    Science.gov (United States)

    Ysunza, Alberto M; Diez-Urdanivia, Silvia; Pérez-Gil, Sara E

    2017-12-01

    Resumen: En este artículo presentamos el proyecto de capacitación llevado a cabo en comunidades de la sierra y costa de Oaxaca, México, desde 1991, por el Centro de Capacitación Integral para Promotores Comunitarios (CECIPROC). La decisión de hacer este trabajo en Oaxaca responde a que ese estado ocupa uno de los primeros lugares de marginación y de desnutrición en menores de 5 años. El objetivo es describir un modelo de capacitación y compartir parte de las experiencias derivadas, tanto del modelo como del trabajo realizado en las distintas áreas (nutrición y alimentación, salud comunitaria, ecología y etnobotánica, y educación y organización), por promotores mujeres y hombres en sus comunidades. La experiencia obtenida en 24 años muestra la factibilidad técnica y social del proyecto en el ámbito de la salud, el reconocimiento social del proyecto del CECIPROC como un organismo civil que ha aportado alternativas como solución a la problemática de salud, el hacer suyo el proyecto por algunos promotores y los diferentes obstáculos a los que se ha enfrentado. Enfatizamos el hecho de que la situación socioeconómica y política prevaleciente en el estado de Oaxaca es una limitante para el buen desarrollo de los programas colectivos de salud, e insistimos en la necesidad de compartir nuestras experiencias para que puedan ser utilizadas en la planificación y ejecución de otros proyectos.

  20. Una experiencia de asesoramiento colaborativo como estrategia de apoyo a los profesores para la implementación de un programa de tutorías universitarias

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    Adilen Carpio Camacho

    2008-01-01

    Full Text Available El presente trabajo hace referencia a las principales conclusiones obtenidas en el desarrollo de la investigación y el asesoramiento colaborativo realizado durante dos cursos académicos, en la Facultad de Contabilidad y Finanzas del Centro Universitario de Sancti Spíritus en Cuba y que tuvo como objetivo central el diseño e implementación de un programa de tutorías universitarias. Si bien el programa diseñado e implementado es, en sí mismo, una experiencia novedosa que ha introducido una propuesta de cambio e innovación en el ámbito de la orientación y la tutoría, en nuestra comunicación nos vamos a centrar en el proceso de asesoramiento colaborativo a través del cual, se ha desarrollado el programa. Esta experiencia nos permite argumentar la necesidad de poner en marcha estrategias de apoyo a los profesores para el diseño y implementación de proyectos de innovación que apunten a la mejora de la formación y atención global al alumnado. De esta experiencia queremos destacar la importancia de que exista un planteamiento institucional y colectivo que apoye y dé sentido a los esfuerzos que se dedican al asesoramiento y a la formación del profesorado, ya que de otra manera sus efectos siempre serán limitados y de poca continuidad.

  1. EXPERIENCIA INTEGRADORA PARA EDUCACIÓN AMBIENTAL

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    Jorge F. Coronel

    2015-01-01

    Full Text Available En este trabajo se relacionó la práctica experimental de laboratorio co n el análisis de problemas ambientales. El objetivo de este trabajo es analizar una propuesta que vinculó el trabajo experimental con la situación del ambiente local para promover el cuidado de la naturaleza y su uso con sostenibilidad . Esta estrategia brindó un enfoque integrador aportando a los alumnos de profesorado una alternativa de aprendizaje con exper iencias sencillas para el estudio cualitativo de l ambiente local y motivar a l análisis de problemas asociad o s. Las experiencias permitieron caracterizar las muestras de suelo, agua y aire del lugar de residencia de los alumnos. La información experimental obtenida potenció la discusión de la situación ambiental actual. E l enfoque de enseñanza basado en problemas socio - científicos posibilit ó la visión interdisciplinar del tema , redimensionando valores y acciones para el cuidado ambiental y el desarrollo sustentable.

  2. Experiencias de adolescentes embarazadas en control prenatal

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    Hilda Evelia Prías-Vanegas

    2009-01-01

    Full Text Available Objetivo: describir e interpretar las experiencias relacionadas con los sentimientos e ideas experimentados por las adolescentes al conocer su estado de embarazo. Método: se trabajó con un grupo de 22 adolescentes de instituciones públicas de I nivel de salud de Sincelejo, Colombia. El estudio, realizado en 2005, se abordó desde un enfoque cualitativo, con información recogida en entrevistas personales, grabadas con consentimiento de las jóvenes. Resultados: el embarazo genera en la adolescente sentimientos de displacer relacionados con miedo, tristeza, dolor, sufrimiento, culpa, vergüenza y decepción, acompañados de ideas de negación, evasión, duda, arrepentimiento y deseos de abortar, los cuales no aparecen cuando la adolescente cuenta con el apoyo de su compañero sentimental o el de sus padres. Conclusión: las adolescentes necesitan apoyo, comprensión y ayuda, dado que están más sensibles, lábiles, inseguras y con baja autoestima, situación que requiere que el equipo de salud desarrolle y muestre competencias en el área humanística, acercamiento personal, empatía y trato humanizado e individualizado en la atención de la población de adolescentes embarazadas.

  3. LA CONSTRUCCIÓN COLECTIVA DE UN PORTAL WEB DE CENTRO. UNA EXPERIENCIA DE INNOVACIÓN SOSTENIBLE

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    Mª Helena Zapico Barbeito

    2010-01-01

    Full Text Available Presentamos una experiencia que forma parte de un estudio más amplio que analiza los factores que dificultan o aceleran los procesos de cambio e innovación en los centros educativos cuando se incorporan TIC. En el contexto socio político y económico en que vivimos, la demanda de innovación es un imperativo que afecta a todos los ámbitos sociales. El sistema educativo no es una excepción, de manera que las escuelas están llamadas a subirse también en ese carro mostrando que son innovadoras. Por ello, el análisis de las innovaciones que tienen lugar en su seno es una oportunidad inmejorable para visualizar las condiciones en las que se desarrollan los procesos educativos. Se parte de la idea de que el potencial de cambio que la incorporación de las TIC podría generar, reside, sobre todo, en la manera en que están involucradas en el proyecto del centro y en el trabajo de reflexión sobre sus potencialidades educativas. Desde una perspectiva de investigación acción colaborativa, se construyeron cuatro estudios de casos: uno de un Centro de Educación Infantil y Primaria (C.E.I.P., un Instituto de Educación Secundaria (I.E.S., un Colegio Público Integrado (C.P.I. y un Centro Rural Agrupado (C.R.A.. En este trabajo, abordaremos el análisis de una experiencia en un Centro Rural Agrupado (C.R.A. de Galicia, en el que están integradas nueve escuelas, donde se imparte el segundo ciclo de Educación Infantil y primero de Primaria. Nuestra intención es la de dar cuenta de algunos de los significados de innovación sostenible en la experiencia de construcción del portal del centro como un espacio educativo.

  4. Análisis de experiencias de aprendizajes basados en proyectos: prácticas colaborativas B-Learning

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    Juan Manuel Trujillo Torres

    2015-01-01

    Full Text Available Viene sucediendo de manera continuada cierto distanciamiento entre espacio educativo y realidad social afirmándose esa relación antagónica entre ambos. Bajo esta consideración, el cambio didáctico-pedagógico y organizativo se conforma, hoy más que nunca, como un reclamo que al mismo tiempo ambiciona aprovechar la integración de las TIC para establecer significativos los procesos de aprendizaje y enseñanza y considerar la gestión y practicidad del conocimiento. Así, los aprendizajes basados en problemas (PBL se conforman como una oportunidad para la comunicación, la colaboración, el compromiso, el ejercicio de un sentimiento transformacional, la innovación reflexiva y crítica, entre otras. De este modo, nuestra experiencia b-learning con herramientas web 2.0, pretende convertirse en una oportunidad para la expresión compartida que irradie en forma significativa un pensamiento vivido fruto de la interacción efectiva con el medio desde el ejercicio de la competencia emocional.

  5. Preventing microvascular complications in type 1 diabetes mellitus

    OpenAIRE

    Viswanathan, Vijay

    2015-01-01

    Patients with complications of diabetes such as retinopathy, nephropathy, and cardiovascular complications have increased hospital stay with greater economic burden. Prevention of complications should be started before the onset of type 1 diabetes mellitus (T1DM) by working on risk factors and thereafter by intervention upon confirmatory diagnosis which can prevent further damage to β-cells. The actual risk of getting microvascular complications like microalbuminuria and retinopathy progressi...

  6. Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability.

    Science.gov (United States)

    Salmon, Andrew H J; Satchell, Simon C

    2012-03-01

    Appreciation of the glomerular microcirculation as a specialized microcirculatory bed, rather than as an entirely separate entity, affords important insights into both glomerular and systemic microvascular pathophysiology. In this review we compare regulation of permeability in systemic and glomerular microcirculations, focusing particularly on the role of the endothelial glycocalyx, and consider the implications for disease processes. The luminal surface of vascular endothelium throughout the body is covered with endothelial glycocalyx, comprising surface-anchored proteoglycans, supplemented with adsorbed soluble proteoglycans, glycosaminoglycans and plasma constituents. In both continuous and fenestrated microvessels, this endothelial glycocalyx provides resistance to the transcapillary escape of water and macromolecules, acting as an integral component of the multilayered barrier provided by the walls of these microvessels (ie acting in concert with clefts or fenestrae across endothelial cell layers, basement membranes and pericytes). Dysfunction of any of these capillary wall components, including the endothelial glycocalyx, can disrupt normal microvascular permeability. Because of its ubiquitous nature, damage to the endothelial glycocalyx alters the permeability of multiple capillary beds: in the glomerulus this is clinically apparent as albuminuria. Generalized damage to the endothelial glycocalyx can therefore manifest as both albuminuria and increased systemic microvascular permeability. This triad of altered endothelial glycocalyx, albuminuria and increased systemic microvascular permeability occurs in a number of important diseases, such as diabetes, with accumulating evidence for a similar phenomenon in ischaemia-reperfusion injury and infectious disease. The detection of albuminuria therefore has implications for the function of the microcirculation as a whole. The importance of the endothelial glycocalyx for other aspects of vascular function

  7. Microvascular Remodeling and Wound Healing: A Role for Pericytes

    Science.gov (United States)

    Dulmovits, Brian M.; Herman, Ira M.

    2012-01-01

    Physiologic wound healing is highly dependent on the coordinated functions of vascular and non-vascular cells. Resolution of tissue injury involves coagulation, inflammation, formation of granulation tissue, remodeling and scarring. Angiogenesis, the growth of microvessels the size of capillaries, is crucial for these processes, delivering blood-borne cells, nutrients and oxygen to actively remodeling areas. Central to angiogenic induction and regulation is microvascular remodeling, which is dependent upon capillary endothelial cell and pericyte interactions. Despite our growing knowledge of pericyte-endothelial cell crosstalk, it is unclear how the interplay among pericytes, inflammatory cells, glia and connective tissue elements shape microvascular injury response. Here, we consider the relationships that pericytes form with the cellular effectors of healing in normal and diabetic environments, including repair following injury and vascular complications of diabetes, such as diabetic macular edema and proliferative diabetic retinopathy. In addition, pericytes and stem cells possessing “pericyte-like” characteristics are gaining considerable attention in experimental and clinical efforts aimed at promoting healing or eradicating ocular vascular proliferative disorders. As the origin, identification and characterization of microvascular pericyte progenitor populations remains somewhat ambiguous, the molecular markers, structural and functional characteristics of pericytes will be briefly reviewed. PMID:22750474

  8. Preventing microvascular complications in type 1 diabetes mellitus

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    Vijay Viswanathan

    2015-01-01

    Full Text Available Patients with complications of diabetes such as retinopathy, nephropathy, and cardiovascular complications have increased hospital stay with greater economic burden. Prevention of complications should be started before the onset of type 1 diabetes mellitus (T1DM by working on risk factors and thereafter by intervention upon confirmatory diagnosis which can prevent further damage to β-cells. The actual risk of getting microvascular complications like microalbuminuria and retinopathy progression starts at glycated hemoglobin (HbA1c level of 7%. As per the American Diabetes Association, a new pediatric glycemic control target of HbA1c 20 years as compared to patients <10 years of age. Screening of these complications should be done regularly, and appropriate preventive strategies should be followed. Angiotensin converting enzyme inhibitors and angiotensin II receptor blocker reduce progression from microalbuminuria to macroalbuminuria and increase the regression rate to normoalbuminuria. Diabetic microvascular complications can be controlled with tight glycemic therapy, dyslipidemia management and blood pressure control along with renal function monitoring, lifestyle changes, including smoking cessation and low-protein diet. An integrated and personalized care would reduce the risk of development of microvascular complications in T1DM patients. The child with diabetes who receives limited care is more likely to develop long-term complications at an earlier age. Screening for subclinical complications and early interventions with intensive therapy is the need of the hour.

  9. [Microvascular decompression for hemifacial spasm. Ten years of experience].

    Science.gov (United States)

    Revuelta-Gutiérrez, Rogelio; Vales-Hidalgo, Lourdes Olivia; Arvizu-Saldaña, Emiliano; Hinojosa-González, Ramón; Reyes-Moreno, Ignacio

    2003-01-01

    Hemifacial spasm characterized by involuntary paroxistic contractions of the face is more frequent on left side and in females. Evolution is progressive and in a few cases may disappear. Management includes medical treatment, botulinum toxin, and microvascular decompression of the nerve. We present the results of 116 microvascular decompressions performed in 88 patients over 10 years. All patients had previous medical treatment. All patients were operated on with microsurgical technique by asterional craniotomy. Vascular compression was present in all cases with one exception. Follow-up was from 1 month to 133 months. Were achieved excellent results in 70.45% of cases after first operation, good results in 9.09%, and poor results in 20.45% of patients. Long-term results were excellent in 81.82%, good in 6.82%, and poor in 11.36% of patients. Hypoacusia and transitory facial palsy were the main complications. Hemifacial spasm is a painless but disabling entity. Medical treatment is effective in a limited fashion. Injection of botulinum toxin has good response but benefit is transitory. Microvascular decompression is treatment of choice because it is minimally invasive, not destructive, requires minimum technical support, and yields best long-term results.

  10. Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?

    Science.gov (United States)

    Yu, Cai-Guo; Zhang, Ning; Yuan, Sha-Sha; Ma, Yan; Yang, Long-Yan; Feng, Ying-Mei; Zhao, Dong

    2016-01-01

    Despite being featured as metabolic disorder, diabetic patients are largely affected by hyperglycemia-induced vascular abnormality. Accumulated evidence has confirmed the beneficial effect of endothelial progenitor cells (EPCs) in coronary heart disease. However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating the uncertain role of EPCs in the pathogenesis of diabetic microvascular disease. In this review, we first illustrate how hyperglycemia induces metabolic and epigenetic changes in EPCs, which exerts deleterious impact on their number and function. We then discuss how abnormal angiogenesis develops in eyes and kidneys under diabetes condition, focusing on "VEGF uncoupling with nitric oxide" and "competitive angiopoietin 1/angiopoietin 2" mechanisms that are shared in both organs. Next, we dissect the nature of EPCs in diabetic microvascular complications. After we overview the current EPCs-related strategies, we point out new EPCs-associated options for future exploration. Ultimately, we hope that this review would uncover the mysterious nature of EPCs in diabetic microvascular disease for therapeutics.

  11. Microvascular Architecture of Hepatic Metastases in a Mouse Model

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    Darshini Kuruppu

    1997-01-01

    Full Text Available Development of effective treatment for hepatic metastases can be initiated by a better understanding of tumour vasculature and blood supply. This study was designed to characterise the microvascular architecture of hepatic metastases and observe the source of contributory blood supply from the host. Metastases were induced in mice by an intrasplenic injection of colon carcinoma cells (106 cells/ml. Vascularization of tumours was studied over a three week period by scanning electron microscopy of microvascular corrosion casts. Metastatic liver involvement was observed initially within a week post induction, as areas approximately 100 μm in diameter not perfused by the casting resin. On histology these spaces corresponded to tumour cell aggregates. The following weeks highlighted the angiogenesis phase of these tumours as they received a vascular supply from adjacent hepatic sinusoids. Direct sinusoidal supply of metastases was maintained throughout tumour growth. At the tumour periphery most sinusoids were compressed to form a sheath demarcating the tumour from the hepatic vasculature. No direct supply from the hepatic artery or the portal vein was observed. Dilated vessels termed vascular lakes dominated the complex microvascular architecture of the tumours, most tapering as they traversed towards the periphery. Four vascular branching patterns could be identified as true loops, bifurcations and trifurcations, spirals and capillary networks. The most significant observation in this study was the direct sinusoidal supply of metastases, together with the vascular lakes and the peripheral sinusoidal sheaths of the tumour microculature.

  12. Preventing microvascular complications in type 1 diabetes mellitus

    Science.gov (United States)

    Viswanathan, Vijay

    2015-01-01

    Patients with complications of diabetes such as retinopathy, nephropathy, and cardiovascular complications have increased hospital stay with greater economic burden. Prevention of complications should be started before the onset of type 1 diabetes mellitus (T1DM) by working on risk factors and thereafter by intervention upon confirmatory diagnosis which can prevent further damage to β-cells. The actual risk of getting microvascular complications like microalbuminuria and retinopathy progression starts at glycated hemoglobin (HbA1c) level of 7%. As per the American Diabetes Association, a new pediatric glycemic control target of HbA1c 20 years as compared to patients <10 years of age. Screening of these complications should be done regularly, and appropriate preventive strategies should be followed. Angiotensin converting enzyme inhibitors and angiotensin II receptor blocker reduce progression from microalbuminuria to macroalbuminuria and increase the regression rate to normoalbuminuria. Diabetic microvascular complications can be controlled with tight glycemic therapy, dyslipidemia management and blood pressure control along with renal function monitoring, lifestyle changes, including smoking cessation and low-protein diet. An integrated and personalized care would reduce the risk of development of microvascular complications in T1DM patients. The child with diabetes who receives limited care is more likely to develop long-term complications at an earlier age. Screening for subclinical complications and early interventions with intensive therapy is the need of the hour. PMID:25941647

  13. Microvascular transplantation and replantation of the dog submandibular gland.

    Science.gov (United States)

    Su, Wan Fu; Jen, Yee Min; Chen, Shyi Gen; Nieh, Shin; Wang, Chih-Hung

    2006-05-01

    Transplantation and replantation of the submandibular gland with microvascular techniques were demonstrated in a previous study, with good gland survival. The application of radiation on the neck bed was attempted to address an actual clinical scenario in this study. Five canine submandibular glands were transplanted using microvascular techniques to the ipsilateral femoral system. Radiotherapy at a dosage level of 3,600 cGy using 600 cGy q.d was delivered to the nasopharyngeal and neck regions 2 weeks after transplantation. The transferred glands were then reintroduced into the original but radiated neck bed. The glands were harvested for histological examination 8 weeks later. Four of five canine submandibular glands can withstand microvascular transplantation and then replantation into a radiated neck bed for at least 8 weeks. However, the salivary function was depleted. The canine submandibular gland can survive the transplantation and replantation for at least 8 weeks in spite of precipitating radiation insult on the neck bed for 3 weeks. Neurorraphy is, however, essential to maintaining the glandular function.

  14. Cell proliferation along vascular islands during microvascular network growth

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    Kelly-Goss Molly R

    2012-06-01

    Full Text Available Abstract Background Observations in our laboratory provide evidence of vascular islands, defined as disconnected endothelial cell segments, in the adult microcirculation. The objective of this study was to determine if vascular islands are involved in angiogenesis during microvascular network growth. Results Mesenteric tissues, which allow visualization of entire microvascular networks at a single cell level, were harvested from unstimulated adult male Wistar rats and Wistar rats 3 and 10 days post angiogenesis stimulation by mast cell degranulation with compound 48/80. Tissues were immunolabeled for PECAM and BRDU. Identification of vessel lumens via injection of FITC-dextran confirmed that endothelial cell segments were disconnected from nearby patent networks. Stimulated networks displayed increases in vascular area, length density, and capillary sprouting. On day 3, the percentage of islands with at least one BRDU-positive cell increased compared to the unstimulated level and was equal to the percentage of capillary sprouts with at least one BRDU-positive cell. At day 10, the number of vascular islands per vascular area dramatically decreased compared to unstimulated and day 3 levels. Conclusions These results show that vascular islands have the ability to proliferate and suggest that they are able to incorporate into the microcirculation during the initial stages of microvascular network growth.

  15. Aprender a innovar: una experiencia on line

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    Joaquín MORENO MARCHAL

    2014-11-01

    Full Text Available La creatividad y la innovación se han convertido en recursos clave en la denominada sociedad del conocimiento, que bien podría ser también llamada sociedad de la innovación. Pero innovar es una actividad compleja, que integra la aplicación de múltiples capacidades, el pensamiento divergente y convergente, la gestión de equipos humanos, la comunicación. Ahora bien, a innovar se puede, y se debe, aprender. Aprender a innovar es un reto y también una obligación para el conjunto del sistema educativo en todos sus niveles. Partiendo de estas consideraciones este trabajo expone una experiencia de aprendizaje de la creatividad y de la innovación a través de un curso totalmente on line basado en la plataforma MOODLE, en el marco del Programa de Formación Permanente de la Universidad de Cádiz. Se presenta un modelo del proceso de innovación, denominado CREALAB, de elaboración propia. Este modelo se ha utilizado como base del proceso de aprendizaje de la creatividad y de la innovación y en el diseño del curso, está organizado en torno a actividades y tiene un carácter iterativo y realimentado. Se presentan además el conjunto del diseño metodológico y los resultados obtenidos en las dos ediciones celebradas hasta el momento. El diseño del curso totalmente on line y los resultados alcanzados permiten estimar un alto potencial de aplicación, tanto a nivel personal como a nivel organizacional.

  16. ¿ESTÁ PREPARADA NUESTRA ORGANIZACIÓN PARA HACER FRENTE A LOS RETOS DE LA INNOVACIÓN?

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    Sabin Azua

    2007-07-01

    Full Text Available Estamos asistiendo a una auténtica competición para distinguir las organizaciones con base en su nivel de innovación. Aún cuando el concepto no está suficientemente claro y todos tenemos una percepción diferente sobre su significado y sus repercusiones sobre la forma de gestionar nuestras organizaciones, nos hemos instalado en una dinámica tendiente a favorecer la generación de entidades más creativas, que buscan elementos de diferenciación frente a sus competidores y, que hacen de la exploración uno de los principales mecanismos de gestión.

  17. Una experiencia de aprendizaje intergeneracional con alumnos universitarios a través de la novela gráfica = An experience of intergenerational learning with college students through the graphic novel

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    Elisa Larrañaga Rubio

    2017-09-01

    Full Text Available Resumen: Presentamos una experiencia docente realizada conjuntamente con alumnos del Grado de Humanidades y alumnos de la Universidad de Mayores. Nuestra herramienta de trabajo ha sido la novela gráfica Arrugas. La incorporación de la novela gráfica en la docencia universitaria nos está posibilitando el cambio deseado en la mayor autonomía del proceso enseñanza-aprendizaje en nuestro alumnado, permitiendo el traspaso de la tradicional docencia universitaria basada en el rol expositivo del docente, hacia un proyecto común con mayor peso de los discentes. La experiencia desarrollada ha favorecido la interrelación entre los alumnos de la Universidad de Mayores y los alumnos de grado. Relación que se ha mantenido más allá de la experiencia de aula. Es importante destacar la alta satisfacción de todos los estudiantes. Todos mostraron su deseo de continuar la docencia conjunta en otras experiencias.Abstract: We present a teaching experience carried out with the degree of Humanities students and students of the University Programs for Seniors. Our tool has been the graphic novel wrinkles. The incorporation of the graphic novel in university teaching us is enabling the change desired greater autonomy process teaching and learning in our students, allowing the transfer of traditional university teaching based on the expository role of the teacher, towards a common project with greater weight of the learners. The experience developed to favor the interrelation between the senior citizens University students and grade students. The relationship has lasted beyond the classroom experience. It is important to highlight the high satisfaction of all students. All showed their desire to continue the joint teaching in other experiences.

  18. La experiencia de la maternidad en mujeres feministas

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    Natalie Sánchez Benítez

    2016-01-01

    Full Text Available El siguiente artículo sitúa sus relexiones sobre la maternidad desde el feminismo y describe cuáles son las e xperiencias de la maternidad cuando se es mujer feminista, para el caso especí- ico de la organización Casa de la Mujer. Los ejes de análisis son: i la experiencia ambivalente del deseo; ii las experiencias de exclusión y vulneración; iii pareja y crianza, encuentros y desencuentros; y iv autonomía. Se concluye que en la experiencia hay varios elementos que potencian la reconiguración subjetiva de las mujeres madres y no madres, feministas y no feministas.

  19. Anarquismo y la emancipación de la mujer: El movimiento anarquista en Argentina y Nuestra Tribuna (1922-1925

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    Laura Catena

    2014-12-01

    Full Text Available This paper analyses the “Nuestra Tribuna” journal written by a group of anarchist women between 1922 and 1925 in Argentina. Focusing on the concept of “women emancipation”, we consider four areas of analysis: the rationalist education, motherhood and the social role of women, religion and marriage as opposed to“free love”, and the relationship between anarchism and feminism. We intend to demonstrate that women of “Nuestra Tribuna” made a significant contribution to the spread of anarchist ideas concerning the emancipation of women, yet differing from feminism.

  20. Unir Gamificación y Experiencia de Usuario para mejorar la experiencia docente

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    Emiliano Labrador

    2016-06-01

    Full Text Available En unos estudios como son las ingenierías TIC se realiza un tipo de asignatura obligatoria y transversal a todos los alumnos. Es una asignatura que trabaja la parte creativa y la parte crítica del alumno, contando que son alumnos con un tipo de perfil de base principalmente tecnológico. Se trata de una asignatura presencial con soporte de una plataforma online que dispone de todos los recursos necesarios para llevarla a cabo. La gamificación forma parte de la asignatura de primer curso de ingeniería, diseño y usabilidad 1. Su aplicación ha sido diseñada y evaluada para iterar constantemente en la metodología y aplicar cambios continuos que mejoren su diseño y, por lo tanto, que mejoren la aplicación con los alumnos. La gamificación se centra principalmente en respetar el contenido de la asignatura: comunicación, diseño gráfico y usabilidad y experiencia de usuario para tenerlo en cuenta en las mecánicas de juego aplicadas. Tras la gamificación del curso 2013-2014, se realizaron encuestas a los alumnos basadas en técnicas de evaluación de experiencia de usuario para poder obtener datos tanto de la aplicación del contenido académico como de los puntos positivos y negativos de las mecánicas aplicadas. Estas encuestas se contrastaron con los resultados académicos de los alumnos tanto de notas parciales como de notas finales. Este artículo muestra los cambios introducidos en el diseño metodológico, su evaluación y sus posteriores resultados. La pregunta que se pretende responder es: ¿las mejoras introducidas han hecho que mejoren los resultados?

  1. La experiencia de las enfermeras ante la muerte

    OpenAIRE

    Alvarez de Arriba, Daniel

    2016-01-01

    Trabajo fin de grado en Enfermería Introducción: Las enfermeras han heredado de la sociedad un concepto histórico de la muerte que en la actualidad se ha convertido en tabú. Esto produce sentimientos negativos cuando enfrentan la muerte de sus pacientes en la práctica diaria. Esta experiencia es común a todas las enfermeras y se encuentra influenciada por diversos factores: la experiencia laboral, unidad de trabajo, creencias religiosas, educación previa y edad del fallecido. Objetivo: ...

  2. Un nuevo contexto para la experiencia de usuario

    OpenAIRE

    Capossio, Ana Paula

    2014-01-01

    ¿Cómo afecta la incorporación de metodologías de diseño centrado en el usuario (DCU) al momento de diseñar una experiencia para una instalación interactiva? Uno de los factores más importantes para una obra de arte interactivo es el usuario, ya que es el que interactúa directamente con la interfaz de la obra. El desafío del artista es conseguir diseñar una interfaz que los usuarios comprendan y entiendan el significado de la obra. Para poder lograr una mejor experiencia de usuario, el arti...

  3. EXPERIENCIAS CONSTRUCTIVAS DEL TERREMOTO DE LORCA

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    José-Carlos Salcedo Hernández

    2012-01-01

    Full Text Available El terremoto de Lorca del 11 de mayo de 2011 es el más importante que ha sufrido el territorio peninsular español en los últimos 55 años, desde el terremoto de Albolote (Granada de 1956 que, casualmente, fue del mismo tipo y tuvo idéntica magnitud de 5,1 grados en la escala Richter. En estos 55 años, la tipología de los edificios ha cambiado completamente, pasando de edificios de muros de fábrica de hasta dos plantas de altura, a la generalización de edificios de pisos de una media de 6 plantas, de pilares y vigas con nudos rígidos y forjados de hormigón. Es importante extraer experiencias constructivas del comportamiento que han tenido los edificios de Lorca, porque es el único caso real de que disponemos, para la mejora de la seguridad estructural antisísmica de los edificios en España. En Lorca se ha constatado el mal comportamiento de las estructuras de fábrica de ladrillo con las que está construido el patrimonio histórico. Se ha probado que, con la sola excepción de un edificio, las estructuras nuevas de hormigón y acero han superado una aceleración sísmica del triple de la prevista por la norma sismorresistente NCSE-02, con la que fueron calculadas. Por el contrario, se ha constatado un pésimo comportamiento de los elementos de fábrica (petos, cerramientos, tabiques, etc, de ladrillo con fracasos generalizados, que son los que produjeron los enormes daños materiales en las viviendas y los daños personales. Estos elementos no son «estructurales», pero la norma NCSE-02 establecía para ellos unas condiciones que no debieron aplicarse en las construcciones realizadas desde su implantación.

  4. Vitamin D levels and microvascular complications in type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Sarita Bajaj

    2014-01-01

    Full Text Available Background: Vitamin D has important actions on glucose metabolism. These include improved insulin exocytosis, direct stimulation of insulin receptor, improved uptake of glucose by peripheral tissues, improving insulin resistance. It has got various pleiotropic effects like suppression of cell mediated immunity, regulation of cell proliferation, stimulation of neurotropic factors such as nerve growth factor, Glial cell line-derived neurotrophic factor, neurotropin, suppression of RAAS, reduction of albuminuria, immunomodulatory effects, and anti-inflammatory effects. Thus, vitamin D is implicated in many ways in the pathogenesis of retinopathy, neuropathy and nephropathy. Objectives: To study the correlation of vitamin D levels with microvascular complications in type 2 diabetes. Materials and Methods: Cross-sectional case-control study of 18 patients (18-70 years, who met the American Diabetes Association 2011 criteria for type 2 diabetes, was conducted. Age and sex matched healthy controls were taken. Subjects were evaluated for the presence of microvascular complications by clinical evaluation, urine examination, fundus examination, nerve conduction studies, and various biochemical tests. 25-OH cholecalciferol levels were done for each. Cut off level for vitamin D deficiency was 20 ng/ml. Results: Mean vitamin D was lower in type 2 diabetics than healthy subjects (19.046 vs. 27.186 ng/ml. Prevalence of vitamin D deficiency and insufficiency was found to significantly higher in diabetics when compared to healthy subjects (P = 0.0001. Vitamin D deficiency was found to be significantly associated with neuropathy (χ2 = 5.39, df = 1, P = 0.020, retinopathy, (χ2 = 6.6, df = 1, P = 0.010 and nephropathy (χ2 = 10. 52, df = 1, P = 0.001. Lower levels of vitamin D were found to be associated with increasing prevalence of combinations of microvascular complications namely neuropathy with retinopathy (P = 0.036, neuropathy with nephropathy (P = 0

  5. The Ubiquitin-Proteasome System and Microvascular Complications of Diabetes

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    Saeed Yadranji Aghdam

    2013-01-01

    Full Text Available The ubiquitin-proteasome system (UPS is the mainstay of protein quality control which regulates cell cycle, differentiation and various signal transduction pathways in eukaryotic cells. The timely and selective degradation of surplus and/or aberrant proteins by the UPS is essential for normal cellular physiology. Any disturbance, delay or exaggeration in the process of selection, sequestration, labeling for degradation and degradation of target proteins by the UPS will compromise cellular and tissue homeostasis. High blood glucose or hyperglycemia caused by diabetes disrupts normal vascular function in several target organs including the retina and kidney resulting in the development of diabetic retinopathy (DR and diabetic nephropathy (DN. We and others have shown that hyperglycemia and oxidative stress modulate UPS activity in the retina and kidney. The majority of studies have focused on the kidney and provided insights into the contribution of dysregulated UPS to microvascular damage in DN. The eye is a unique organ in which a semi-fluid medium, the vitreous humor, separates the neural retina and its anastomosed blood vessels from the semi-solid lens tissue. The complexity of the cellular and molecular components of the eye may require a normal functioning and well tuned UPS for healthy vision. Altered UPS activity may contribute to the development of retinal microvascular complications of diabetes. A better understanding of the molecular nature of the ocular UPS function under normal and diabetic conditions is essential for development of novel strategies targeting its activity. This review will discuss the association of retinal vascular cell UPS activity with microvascular damage in DR with emphasis on alterations of the PA28 subunits of the UPS.

  6. Sleep quality and duration are related to microvascular function: the Amsterdam Growth and Health Longitudinal Study

    NARCIS (Netherlands)

    Bonsen, T.; Wijnstok, N.J.; Hoekstra, T.; Eringa, E.C.; Serne, E.H.; Smulders, Y.M.; Twisk, J.W.R.

    2015-01-01

    Sleep and sleep disorders are related to cardiovascular disease, and microvascular function is an early cardiovascular disease marker. Therefore, the relationship of sleep (measured in sleep quality and duration) with microvascular function was examined in healthy adults. Sleep quality was assessed

  7. Perioperative antibiotics in the setting of microvascular free tissue transfer: current practices

    NARCIS (Netherlands)

    Reiffel, Alyssa J.; Kamdar, Mehul R.; Kadouch, Daniel J. M.; Rohde, Christine H.; Spector, Jason A.

    2010-01-01

    Microvascular free tissue transfer is a ubiquitous and routine method of restoring anatomic defects. There is a paucity of data regarding the role of perioperative antibiotics in free tissue transfer. We designed a survey to explore usage patterns among microvascular surgeons and thereby define a

  8. Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation

    NARCIS (Netherlands)

    Sinaasappel, M.; van Iterson, M.; Ince, C.

    1999-01-01

    1. The aim of this study was to investigate the relation between microvascular and venous oxygen pressures during haemorrhagic shock and resuscitation in the pig intestine. To this end microvascular PO2 (microPO2) was measured by quenching of Pd-porphyrin phosphorescence by oxygen and validated for

  9. Profile of Microvascular Disease in Type 2 Diabetes in a Tertiary ...

    African Journals Online (AJOL)

    Background: Diabetes mellitus (DM) is a metabolic disorder complicated by microvascular and macrovascular diseases. The clinical profile of these complications has not been adequately studied in many tertiary health care centers in India. Aim: The authors studied the clinical profile of microvascular diabetes ...

  10. Experiencia en el aula de secundaria con fractales

    OpenAIRE

    Gallardo, Sandra; Martínez-Santaolalla, Manuel José; Molina, Marta; Peñas, María; Cañadas, María C.; Crisóstomo, Edson

    2006-01-01

    Presentamos una experiencia docente en un aula de 2º ESO en la que trabajamos los fractales mediante el uso de material de carácter manipulativo. La metodología seguida se basa en la construcción de casos particulares con el fin de llegar al concepto de fractal.

  11. Estudio de Caso de la Experiencia Subjetiva del Cuerpo

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    Edith Flores Pérez

    2007-01-01

    Full Text Available Estudio de caso que explora la experiencia subjetiva del cuerpo en la trayectoria con el uso de drogas a través del relato de vida. Se utilizó la entrevista abierta bajo los supuestos metodológicos del relato autobiográfico. Se propuso al participante “Hablar de sí mismo y contar su experiencia con el uso de drogas”. La estrategia analítica se diseñó con base en la propuesta de Barthes (1990 para el análisis estructural de los relatos. Los resultados muestran que en el relato emerge una subjetividad que articula modos de haber sido y ser cuerpo como instancias constitutivas de la existencia. Desde el punto de vista de la corporalidad, la trayectoria con el uso de drogas deviene en una relación de saber-poder con el propio cuerpo, donde la experiencia subjetiva se entreteje en una red de controles y normas sociales. El análisis del cuerpo como experiencia enriquece la comprensión de prácticas como el uso de drogas.

  12. Craneoplastia en deformidad postraumática y postquirúrgica, 18 años de experiencia en el Hospital General de México: una opción reconstructiva segura

    Directory of Open Access Journals (Sweden)

    Juan-Antonio Ugalde-Vitelly

    Full Text Available Introducción y Objetivos: Los defectos craneales que llegan a nuestro hospital generalmente son secundarios a trauma o bien a su tratamiento neuroquirúrgico. La craneoplastia no suele ser inmediata, sin embargo el síndrome de trepanación o el deseo del paciente por mejorar su apariencia, son mandatorios para poder realizar la reconstrucción. El material ideal para una craneoplastia debe ser biocompatible, fácil de fabricar y biomecánicamente estable. En nuestro Servicio llevamos a cabo la reconstrucción craneal con una prótesis de metil-metacrilato diseñada mediante estereolitografía, cubierta completamente por un injerto de fascia lata. En nuestra experiencia esta nos brinda resultados predecibles, seguros y satisfactorios para los pacientes. Material y Método: Presentamos nuestra experiencia inicial en el uso de esta técnica a través de un análisis retrospectivo sobre 32 pacientes operados por un equipo multidisciplinario entre enero de 1996 y junio de 2014 en el Hospital General de México Dr. Eduardo Liceaga. Resultados: No tuvimos complicaciones importantes relacionadas con infección, hematoma o seroma. Los resultados estéticos obtenidos fueron de aceptables a buenos. Conclusiones: En esta serie de pacientes usando la técnica descrita, recogimos una tasa de complicaciones muy baja y un excelente grado de satisfacción de los pacientes en el seguimiento a largo plazo.

  13. 66. Experiencia de 11 años en el entrenamiento de residentes en procedimientos de ablación quirúrgica concomitante de la fibrilación auricular en nuestra institución

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    E. Martín

    2012-04-01

    Conclusiones: El aprendizaje tutelado de la ablación quirúrgica concomitante por crioablación puede llevarse a cabo de forma segura durante la formación MIR, pudiendo alcanzar resultados asimilables a los de los cirujanos de staff al término de la misma.

  14. Seguimiento a largo plazo de pacientes con disfunción ventricular izquierda intervenidos de sustitución valvular aórtica. Experiencia en nuestra institución

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    Gemma Candela-Navarro

    2016-07-01

    Conclusiones: La sustitución valvular aórtica es una opción segura, eficaz y duradera en pacientes con disfunción ventricular izquierda. Se asocia a una mejoría en la clase funcional y fracción de eyección, con una perspectiva de futuro excelente.

  15. ¿Es necesario disponer de ECMO para reparar cardiopatías congénitas de complejidad elevada? Nuestra experiencia en los últimos 6 años

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    Raúl Sánchez Pérez

    2017-01-01

    Conclusiones: Creemos que actualmente es necesario disponer de la ECMO en el postoperatorio de los pacientes intervenidos de cardiopatías congénitas, dado que parece asociarse a un beneficio en términos de supervivencia.

  16. Laparoscopic cholecystectomy in patients over 70 years of age: review of 176 cases Colecistectomía laparoscópica en pacientes mayores de 70 años: nuestra experiencia en 176 casos

    Directory of Open Access Journals (Sweden)

    F. J. Pérez Lara

    2006-01-01

    Full Text Available Introduction: we assessed the results of laparoscopic cholecystectomy in 176 patients over the age of 70 years. Patients and methods: the study included all patients older than 70 years of age who underwent laparoscopic surgery cholelithiasis during the previous ten years. Variables studied included age, sex, type of operation (programmed/emergency, comorbidity, anesthetic risk, intraoperative cholangiography, conversion to open surgery, number of trocars, reoperation, residual choledocholithiasis, postoperative hospital stay, morbidity and mortality. Results: the study included 176 patients (23.29% men and 76.71% women. The mean age was 74.86 years. The mean hospital stay was 1.27 days, with 16.98% morbidity and 0.56% mortality. Conclusions: laparoscopic cholecystectomy is a safe procedure in older patients. It results in faster recovery, a shorter postoperative stay and lower rates of morbidity and mortality than open bile duct surgery.Objetivo: el objetivo de nuestro estudio es el de evaluar los resultados obtenidos en 176 pacientes mayores de 70 años intervenidos mediante colecistectomía laparoscópica. Pacientes y métodos: se incluyen en el estudio todos los pacientes mayores de 70 años diagnosticados de colelitiasis intervenidos por laparoscopia en los diez últimos años. Analizamos los siguientes parámetros: edad, sexo, tipo de intervención (programada/urgente, comorbilidad, riesgo anestésico, colangiografía intraoperatoria, conversión a cirugía abierta, número de trócares, reintervención, coledocolitiasis residual, estancia hospitalaria postoperatoria y morbimortalidad. Resultados: incluimos en el estudio un total de 176 pacientes, de los cuales el 23,29% son varones y 76,71%, tienen una edad media de 74.86 años. En los resultados globales la estancia media hospitalaria es de 1,27 días, morbilidad 16,98% y mortalidad de 0,57%. Conclusiones: la colecistectomía laparoscópica es un procedimiento seguro en pacientes mayores, ofreciendo una más temprana recuperación, menor estancia postoperatoria, y una menor tasa de morbimortalidad que la cirugía biliar abierta.

  17. Rinorrea traumática de líquido cefalorraquídeo: Nuestra experiencia en su diagnóstico y tratamiento Traumatic cerebrospinal fluid rhinorrhea.: Our experience in diagnosing and treating this illness.

    Directory of Open Access Journals (Sweden)

    Oscar N. García-Roco Pérez

    2006-08-01

    Full Text Available Se realizó un estudio observacional descriptivo longitudinal en el Hospital Clinicoquirúrgico Provincial Docente”Manuel Ascunce Domenech” de Camagüey, en el período de enero a diciembre del 2004, para evaluar el manejo diagnóstico y terapéutico de la rinorrea traumática de líquido cefalorraquídeo (LCR. Se seleccionaron previo consentimiento informado 16 pacientes provenientes del Servicio de Urgencias. De estos, 11 fueron hombres y el 32 % se encontraba en las edades comprendidas entre 15 y 29 años. Se determinaron síntomas asociados, estudios complementarios, tratamiento médico-quirúrgico, complicaciones y evolución. Se realizó estadística descriptiva e inferencial. Los síntomas más frecuentes fueron las cefaleas (87,5 %, anosmia y vértigos. Los métodos diagnósticos más efectivos fueron la inspección visual (100,0 %, la TAC simple y la rinoscopia. Los tratamientos más frecuentes fueron la antibioticoterapia y reducción de fracturas Lefort y nasoetmoidales con 62,5 % y 87,5 %, respectivamente. El 81,3 % de los casos evolucionó favorablemente, solo 2 (12,5 % se complicaron con meningitis.A longitudinal, descriptive and observational study was undertaken from January to December, 2003 at “Manuel Ascunce Domenech” clinical and surgical hospital in Camaguey province, for the purpose of evaluating the diagnostic and therapeutic management of traumatic cerebrospinal fluid rhinorrhea. After obtaining their informed consent, 16 patients from the Emergency Dental Service were selected. Eleven of them were males and 32% was in the 15-29 years old group. Associated symptoms, supplementary studies, medical & surgical treatment, complications and recovery period were considered. Descriptive and inference statistics were used. The most frequent symptoms were headaches (87,5%, anosmia and dizziness. The most effective diagnosing methods were visual survey (100%, simple CT and rhinoscopy. The most common treatment regimes were antibiotic therapy and LeFort and nasoethmoidal fracture reduction with 62,5% and 87,5% of cases respectively. Recovery was satisfactory in 81,3% of cases, although two (12,5% suffered complications from meningitis.

  18. EXPERIENCIAS EXTRASENSORIALES Y EXPERIENCIAS ALUCINATORIAS: EXAMINANDO LA HIPÓTESIS DEL CONTINUO DE EXPERIENCIAS ESQUIZOTÍPICAS/ EXTRASENSORIAL AND HALLUCINATORY EXPERIENCES: EXAMINING THE CONTINUOUS THEORY ON SCHIZOTYPAL EXPERIENCES

    Directory of Open Access Journals (Sweden)

    Alejandro Parra*

    2010-05-01

    Full Text Available RESUMENUna experiencia extrasensorial es aquella en la que parece que la mente de una persona ha adquirido la informaciónremota, es decir, aparentemente sin la mediación de los sentidos humanos conocidos o procesos de inferencia lógica. Portanto, lo «extrasensorial» en la experiencia extrasensorial corresponde a juzgar por las apariencias y no necesariamente a larealidad, mientras que lo «extrasensorial» en la percepcion extrasensorial se refiere a la naturaleza de una presunta realidadparanormal. Se ponen a prueba dos hipótesis específicas: Una muestra de estudiantes argentinos que reportan haber tenidoexperiencias extrasensoriales tienen mayor capacidad de experimentar (1 alucinaciones visuales y táctiles, y (2 propensióna la esquizotipia en comparación con quienes no tuvieron experiencias extrasensoriales. Los resultados mostraron mayornivel de esquizotipia cognitivo-perceptual y propensión a la alucinación en individuos con experiencias que quienes no lastuvieron. Los resultados sugieren que hay procesos disociativos subyacentes, como absorción y propensión a la fantasía,que parecen estar asociadas a las experiencias extrasensoriales.ABSTRACTAn extrasensory experience is one in which it appears that the experient’s mind has acquired information directly, thatis, seemingly without either the mediation of the recognized human senses or the processes of logical inference. The«extrasensory» in extrasensory experience therefore pertains to appearances and not necessarily to reality, whereas the«extrasensory» in extrasensory perception refers to the nature of a hypothesized paranormal reality. Two specific hypothesesare tested: A sample of Argentinean participants who have reported Extrasensorial experiences have a higher capacity for (1visual and tactile hallucination, and (2 schizotypy proneness than non--experients. The results showed a higher level ofcognitive-perceptual schizotypy and hallucination proneness in

  19. METODOLOGÍA DIALÓGICA E INTERDISCIPLINA EN LA EXTENSIÓN UNIVERSITARIA. REFLEXIONES ACERCA DE UNA EXPERIENCIA.

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    Paula Viviana Soza Rossi

    2013-07-01

    Full Text Available El trabajo es el resultado de nuestras reflexiones sobre la metodología dialógica y la conformación de equipos interdisciplinarios en procesos de investigación-acción. Las mismas surgieron a partir de una experiencia de extensión universitaria desarrollada en la Universidad Nacional de La Plata - Argentina en conjunto con la Comisión Provincial por la Memoria (CPM y la Asociación de Trabajadores del Estado- Provincia de Buenos Aires (ATE. El proyecto buscaba un acceso, apropiación y resignificación colectiva de los  documentos pertenecientes al Archivo de la ex – Dirección de Inteligencia de la Policía de la Provincia de Buenos Aires (DIPBA, en guarda de la CPM. Es decir, un encuentro entre esos documentos que contenían parte de la historia argentina de persecución, represión pero también prácticas de resistencias,  y sus protagonistas. El trabajo busca identificar los nudos problemáticos y las potencialidades de la experiencia, así como reconstruir la apuesta metodológica que se constituyó a partir de la disposición al diálogo y de la conformación de un NOS-OTROS. En este proceso se  analiza la presencia de una perspectiva dialógica en la conceptualización de la noción de extensión; en la opción metodológica por la investigación acción-participativa y sus tensiones presentes en el campo; en la forma de pensar y actuar interdisciplinariamente construyendo un otro extensionista; y en la decisión  a partir de las necesidades situadas planteadas por los/as trabajadores de incorporar específicamente el diálogo intergeneracional e intergénero. Una posición que nos permitió un diálogo entre sujetos participantes de la experiencia de extensión y la elaboración colectiva de los denominados procesos de “re” (Vasilachis, 2007. Redefinición de la identidad, redefinición discursiva ante la mirada de los otros (la DIPBA y una redefinición de la memoria colectiva de los/as trabajadores/as del sindicato a

  20. Optically measured microvascular blood flow contrast of malignant breast tumors.

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    Regine Choe

    Full Text Available Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geometry. The probe employs diffuse correlation spectroscopy (DCS, a near-infrared optical method that quantifies deep tissue microvascular blood flow. Tumor-to-normal perfusion ratios are derived from thirty-two human subjects. Mean (95% confidence interval tumor-to-normal ratio using surrounding normal tissue was 2.25 (1.92-2.63; tumor-to-normal ratio using normal tissues at the corresponding tumor location in the contralateral breast was 2.27 (1.94-2.66, and using normal tissue in the contralateral breast was 2.27 (1.90-2.70. Thus, the mean tumor-to-normal ratios were significantly different from unity irrespective of the normal tissue chosen, implying that tumors have significantly higher blood flow than normal tissues. Therefore, the study demonstrates existence of breast cancer contrast in blood flow measured by DCS. The new, optically accessible cancer contrast holds potential for cancer detection and therapy monitoring applications, and it is likely to be especially useful when combined with diffuse optical spectroscopy/tomography.

  1. La experiencia del proyecto EMILIA en Barcelona. El usuario como experto: concepto, modalidades y experiencia desde el Proyecto Emilia.

    OpenAIRE

    Paz Flores; Carmen Masferrer; Eithne Leahy; Roser Izquierdo; Eduard Palomer

    2010-01-01

    Se relata la experiencia del proyecto EMILIA y se ofrece una visión global de qué se entiende por “usuario experto” y “implicación de los usuarios” en salud mental. Se discuten sus implicaciones para los profesionales, usuarios y el sistema sanitario.

  2. The White Male as Narrative Axis in Mayra Santos-Febres’s Nuestra señora de la noche

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    Helene C. Weldt-Basson

    2013-01-01

    Full Text Available Mayra Santos-Febres’s 2006 novel, Nuestra señora de la noche , is based on the life of the Puerto Rican madam, Isabel la Negra, a legendary figure in Puerto Rican culture. Using both Mervin Alleyne’s theory of racial discrimination and Aída Hurtado’s theory of racially-based gender discrimination, which shows how the reactions of white and black females are governed by their relation of dependency on or rejection by the white male, this study illustrates how the character Isabel la Negra evolves as a postmodern, feminist character who opposes racism and gender subordination in Puerto Rico through her role as a prostitute. Conversely, the study also illustrates how madness, associated with both white (Cristina Rangel and black (Montse females in the novel, is a powerless rather than feminist strategy, into which women descend due to their mistreatment by patriarchal society. The study illustrates how Fernando Fornarís, the white male protagonist, serves as the narrative axis for the development of women’s polarized reactions to patriarchal domination in the novel.

  3. Colaborar con África: la experiencia del retorno Work with Africa: The experience of returning

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    Carmen Jerez Molina

    2010-09-01

    Full Text Available El Hospital de San Juan de Dios colabora desde 2002 con el St. John of God Hospital en Mabesseneh (Sierra Leona cuando éste retoma la actividad asistencial tras la guerra civil del 1991. Parte de la colaboración consiste en enviar cada dos meses un pediatra y una enfermera. Todos estos profesionales inician el proyecto con un concepto de salud occidental, con ideas de cambio... Al volver ¿Qué ha sucedido? ¿Han cambiado el mundo africano o éste les ha cambiado? De estos interrogantes parte nuestra investigación. Metodología: Se realizaron entrevistas no directivas a siete enfermeras colaboradoras con el programa. El enfoque utilizado en esta investigación es el fenomenológico. Los datos se analizaron mediante el enfoque de Taylor y Bogdan para el análisis de datos cualitativos. Resultados: las personas entrevistadas dicen que aprendes a valorar lo que existe en el mundo occidental. La práctica enfermera al principio parece que cambia, pero el ser humano se adapta al entorno tanto cuando uno llega a África como cuando retorna. La impregnación de estas experiencias construye la persona. Encontramos escasas diferencias en personas que han ido más de una vez. Conclusiones: Las experiencias de cada persona pueden ser muy distintas teniendo en cuenta los objetivos de los que se parte. Al igual que la impregnación de lo vivido. Pero sí se hace evidente que, tras el tiempo pasado, el cambio en la práctica asistencial no es significativo.The Hospital de San Juan de Dios collaborates since 2002 with the Hospital from St. John of God Hospital in Mabesseneh (Sierra Leone when the last resumed its activity after the Civil war of 1991. A part of this collaboration consists in sending a nurse and a paediatrician every two months. All these professional start the project with a "Western" concept of Health, with some ideas of change.... When they are back at home... What has happened? Have they changed the African world or has it changed then

  4. Nuestra verdad sobre SYNTAX

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    Manuel Carnero-Alcázar

    2017-01-01

    Full Text Available El ensayo clínico Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX ha marcado un hito en la historia de la revascularización miocárdica. El análisis del objetivo primario demostró que la cirugía era capaz de reducir el riesgo de eventos cardiovasculares mayores frente al intervencionismo coronario con stents recubiertos en pacientes con enfermedad multivaso o del tronco coronario. Sin embargo, la interpretación de los análisis de subgrupos y eventos secundarios ha servido para justificar la revascularización con stents recubiertos en grupos seleccionados de enfermos. Las conclusiones de SYNTAX han tenido un gran y discutido impacto en las guías de revascularización miocárdica europeas y en la práctica clínica diaria, forzando nuevas indicaciones, fomentando la reunión del Heart Team y poniendo a nuestro alcance nuevas herramientas como SYNTAX score. Los cirujanos cardiacos y cardiólogos hemos asumido todos estos cambios sin apenas crítica. Pero, ¿cuánta verdad irrefutable hay en SYNTAX?

  5. Revivamos nuestra historia

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    Myriam Bautista

    2015-12-01

    Full Text Available El paraíso del diablo. Roger Casement y el informe del Putumayo, un siglo después. Claudia Steiner Sampedro, Carlos Páramo Bonilla, Roberto Pineda Camacho (Compiladores. Universidad de los Andes, Facultad de Ciencias Sociales, Departamento de Antropología; Universidad Nacional de Colombia, Facultad de Ciencias Humanas, Departamento de Antropología, Bogotá, 2014, 462 págs., il.

  6. Administrando nuestras propias competencias

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    Enrique Louffat

    2013-07-01

    Full Text Available El presente artículo emplea algunas variables de análisis como son: la filosofía laboral, el modelo de organización, la responsabilidad por el manejo de carrera, la evaluación de la carrera, los criterios de satisfacción, el perfil general del funcionario, la movilidad, el riesgo y las competencias. Muestra como la administración individual de carreras ha evolucionado de un contexto tradicional a un contexto moderno, donde se aprecian cambios relevantes que exigen de las personas un nuevo reposicionamiento personal para poder auto-administrar eficientemente su propia carrera. Este contexto moderno, denominado de carreras sin fronteras ni límites, implica tener que quebrar viejos paradigmas e invita a que las personas tengan que desarrollar y/o mejorar nuevas competencias en sus meta-habilidades, beta-habilidades, habilidades operativas, habilidades interpersonales y habilidades directivas con el propósito de alcanzar un eficaz y eficiente “carrera de vida” que involucra el desarrollo integraldel ser humano en sus dimensiones espiritual, emocional, racional y fisiológica.

  7. Una experiencia de innovación docente en el ámbito universitario. Uso de las nuevas tecnologías

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    Sein-Echaluce Lacleta, M.ª Luisa

    2009-09-01

    Full Text Available Several teaching initiatives and experiments, carried out by the authors, are presented in this paper. By means of Moodle (an e-learning platform as a support to on-site teaching, they were applied to some Mathematics subjects of Engineering degrees at the University of Zaragoza. The learning projects, started up over the last few years, have been influenced by the context in which they have been applied. Therefore, we will indicate the strengths and weaknesses which have been detected as influential factors in the design of the courses. Furthermore, our experiments are presented with an explanation of the design of the courses, the methodology and the activities used in the learning units of which they consist as well as of the way to carry out the proactive and reactive tutorial tasks in a blended-learning environment.En este artículo exponemos algunas de las iniciativas docentes y experiencias que hemos llevado a cabo las autoras en algunas asignaturas de Matemáticas de titulaciones de Ingeniería de la Universidad de Zaragoza y dentro del ámbito de la enseñanza presencial con ayuda de la plataforma electrónica de aprendizaje Moodle. Los proyectos de aprendizaje que hemos ido poniendo en marcha durante estos últimos años han estado condicionados por el contexto en el que se están aplicando, por ello indicamos aquí las fortalezas y debilidades que hemos detectado como factores influyentes en el diseño de los cursos. Asimismo, presentamos nuestras experiencias explicando el diseño de los cursos, la metodología y actividades que usamos en las unidades de aprendizaje que los conforman y la forma en que hemos puesto en marcha tutorías proactivas y reactivas en el entorno de aprendizaje semipresencial.

  8. Uterine microvascular sensitivity to nanomaterial inhalation: An in vivo assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stapleton, P.A.; McBride, C.R.; Yi, J.; Nurkiewicz, T.R., E-mail: tnurkiewicz@hsc.wvu.edu

    2015-11-01

    With the tremendous number and diverse applications of engineered nanomaterials incorporated in daily human activity, exposure can no longer be solely confined to occupational exposures of healthy male models. Cardiovascular and endothelial cell dysfunction have been established using in vitro and in situ preparations, but the translation to intact in vivo models is limited. Intravital microscopy has been used extensively to understand microvascular physiology while maintaining in vivo neurogenic, humoral, and myogenic control. However, a tissue specific model to assess the influences of nanomaterial exposure on female reproductive health has not been fully elucidated. Female Sprague Dawley (SD) rats were exposed to nano-TiO{sub 2} aerosols (171 ± 6 nm, 10.1 ± 0.39 mg/m{sup 3}, 5 h) 24-hours prior to experimentation, leading to a calculated deposition of 42.0 ± 1.65 μg. After verifying estrus status, vital signs were monitored and the right horn of the uterus was exteriorized, gently secured over an optical pedestal, and enclosed in a warmed tissue bath using intravital microscopy techniques. After equilibration, significantly higher leukocyte-endothelium interactions were recorded in the exposed group. Arteriolar responsiveness was assessed using ionophoretically applied agents: muscarinic agonist acetylcholine (0.025 M; ACh; 20, 40, 100, and 200 nA), and nitric oxide donor sodium nitroprusside (0.05 M; SNP; 20, 40, and 100 nA), or adrenergic agonist phenylephrine (0.05 M; PE; 20, 40, and 100 nA) using glass micropipettes. Passive diameter was established by tissue superfusion with 10{sup −4} M adenosine. Similar to male counterparts, female SD rats present systemic microvascular dysfunction; however the ramifications associated with female health and reproduction have yet to be elucidated. - Highlights: • Female reproductive health associated with nanomaterial exposure is understudied. • We examined uterine microvascular alterations 24-hours after nano

  9. [Recent advances on pericytes in microvascular dysfunction and traditional Chinese medicine prevention].

    Science.gov (United States)

    Liu, Lei; Liu, Jian-Xun; Guo, Hao; Ren, Jian-Xun

    2017-08-01

    Pericytesis a kind of widespread vascular mural cells embedded within the vascular basement membrane of blood microvessels, constituting the barrier of capillaries and tissue spaces together with endothelial cells. Pericytes communicate with microvascular endothelial cells through cell connections or paracrine signals, playing an important role in important physiological processes such as blood flow, vascular permeability and vascular formation. Pericytes dysfunction may participate in some microvascular dysfunction, and also mediate pathological repair process, therefore pericytes attracted more and more attention. Traditional Chinese medicine suggests that microvascular dysfunction belongs to the collaterals disease; Qi stagnation and blood stasis in collaterals result in function imbalance of internal organs. Traditional Chinese medicine (TCM) has shown effects on pericytes in microvascular dysfunction, for example qi reinforcing blood-circulation activating medicines can reduce the damage of retinal pericytes in diabetic retinopathy. However, there are some limitations of research fields, inaccuracy of research techniques and methods, and lack of mechanism elaboration depth in the study of microvascular lesion pericytes. This paper reviewed the biological characteristics of pericytes and pericytes in microvascular dysfunction, as well as the intervention study of TCM on pericytes. The article aims to provide reference for the research of pericytes in microvascular dysfunction and the TCM study on pericytes. Copyright© by the Chinese Pharmaceutical Association.

  10. LA POSESIÓN DEL ABORIGEN EN NUESTRA SEÑORA DE TALAVERA DE MADRID DE ESTECO (1609-1650

    Directory of Open Access Journals (Sweden)

    Norma Estela Aguilar

    2013-01-01

    Full Text Available Los núcleos urbanos de Talavera y la Villa de Nueva Madrid transitaban, en los primeros años del S. XVII, un proceso de franca decadencia. El traslado y fusión de ambas al sitio de Río de las Piedras, con el nombre de Nuestra Señora de Talavera de Madrid de Esteco, buscaba revertir la tendencia hacia el empobrecimiento. Las acciones llevadas adelante por Alonso de la Ribera, devuelven la imagen de un acto fundacional, en el que la asignación de mercedes, vecindad, aborígenes y tierras, tuvieron como fin incentivar a los pobladores a permanecer en el sitio y a contribuir con la conquista y defensa. El espacio puso en hechos la expresión de Alfaro: “ y faltando indios no hay riquezas, así considerando la causa espiritual como temporalmente”. La disminución de los naturales encomendados señaló de manera inexorable su decadencia, motivada, según los indicios que señalan las fuentes, por la persistencia del servicio personal. La permanencia de este sistema de dominación directa entre el español y el indio se habría dado al amparo de las modificaciones hechas para la Gobernación del Tucumán a las Ordenanzas de Alfaro y de las permisiones dadas por los Gobernadores a los pobladores al momento del traslado, so pretexto de la idiosincrasia particular de los encomendados, entre ellos los Lules.

  11. The Mediated Learning Experience and the Mediator’s Implications La experiencia de aprendizaje mediado y las implicaciones del mediador

    Directory of Open Access Journals (Sweden)

    Fanny Stella Torres Vigoya

    2005-10-01

    Full Text Available It is clear that educators can affect learning positively or negatively, that a personal or professional attitude will immediately change the awareness pupils have toward our classes. Furthermore, as educators, we can not encourage in our pupils the development of good cognitive and socioemotional strategies if we do not constitute ourselves as a model to be followed. On account of these considerations, this article focuses on what Feuerstein (1986 has termed “mediation”, its conditions and the mediator’s profile. Thus, as language teachers, we have to think about the way we could improve and enrich the experience we are offering our pupils in order to make them feel and be intelligent cognitively and emotionally.Es claro que como educadores podemos afectar el aprendizaje de manera positiva o negativa y que una actitud personal o profesional podría cambiar de manera inmediata la disposición que tienen nuestros estudiantes hacia nuestra clase. Además, como educadores no podemos promover en nuestros educandos el desarrollo de estrategias cognitivas y socio-emocionales positivas si nosotros mismos no nos constituimos en un modelo digno de ser seguido. Teniendo en cuenta estas consideraciones, este artículo se enfoca en lo que Feuerstein (1986 llama “mediación”, sus condiciones y el perfil del mediador. Como profesores de idiomas debemos reflexionar acerca de las maneras como podríamos mejorar y enriquecer la experiencia que le estamos ofreciendo a nuestros estudiantes para que ellos se sientan y se hagan inteligentes tanto cognitiva como emocionalmente.

  12. Antes de los Estudios Culturales. Robert Warshow y la experiencia

    Directory of Open Access Journals (Sweden)

    Antonio Lastra

    2008-01-01

    Full Text Available Este artículo estudia la influencia del concepto de experiencia que desarrolla Robert Warshow. Warshow ha supuesto el contrapunto americano a las teorías desarrolladas por Walter Benjamien en Europa. Si bien ambos insistieron en la pobreza de la experiencia, como resultado de la tecnificación de la sociedad, Warshow supo introducir matizaciones que influyeron en todo el círculo de intelectuales concentrados en Nueva York durante la etapa de consolidación de los Estudios Culturales. This paper studies the influence of the experience concept by Robert Warshow. Warshow is the American counterpoint to theories developed by Walter Benjamin in Europe. Although both insisted in the poverty of experience, as a result of technique, Warshow knew how to introduce nuances that influenced intellectuals in New York as Cultural Studies emerged.

  13. Arquitectura para aguijonear la experiencia de conocer en la escuela

    Directory of Open Access Journals (Sweden)

    Diego Emilio Clementin

    2017-09-01

    Full Text Available El presente artículo es una invitación para que los docentes asumamos el desafío de afirmarnos como media­dores de cultura en el marco de un vínculo pedagógico no autoritario, esto significa asumir la responsabilidad de transmitir conocimientos, aguijonear la experiencia de conocer; ulteriormente, el alumno hará con esos co­nocimientos lo que quiera, pueda o necesite, pero luego de haberlos tenido a disposición. Para desarrollar un tema, en el marco de un vínculo pedagógico no autoritario que pueda aguijonear la experiencia de conocer de los alumnos, se sugiere considerar las fases de construcción, elaboración, ejercitación y aplicación durante las clases, no de manera aislada, sino muy articuladas entre sí. 

  14. Oscillations and Multiple Equilibria in Microvascular Blood Flow.

    Science.gov (United States)

    Karst, Nathaniel J; Storey, Brian D; Geddes, John B

    2015-07-01

    We investigate the existence of oscillatory dynamics and multiple steady-state flow rates in a network with a simple topology and in vivo microvascular blood flow constitutive laws. Unlike many previous analytic studies, we employ the most biologically relevant models of the physical properties of whole blood. Through a combination of analytic and numeric techniques, we predict in a series of two-parameter bifurcation diagrams a range of dynamical behaviors, including multiple equilibria flow configurations, simple oscillations in volumetric flow rate, and multiple coexistent limit cycles at physically realizable parameters. We show that complexity in network topology is not necessary for complex behaviors to arise and that nonlinear rheology, in particular the plasma skimming effect, is sufficient to support oscillatory dynamics similar to those observed in vivo.

  15. ABCD1 dysfunction alters white matter microvascular perfusion

    DEFF Research Database (Denmark)

    Lauer, Arne; Da, Xiao; Hansen, Mikkel Bo

    2017-01-01

    Cerebral X-linked adrenoleukodystrophy is a devastating neurodegenerative disorder caused by mutations in the ABCD1 gene, which lead to a rapidly progressive cerebral inflammatory demyelination in up to 60% of affected males. Selective brain endothelial dysfunction and increased permeability...... of the blood–brain barrier suggest that white matter microvascular dysfunction contributes to the conversion to cerebral disease. Applying a vascular model to conventional dynamic susceptibility contrast magnetic reson- ance perfusion imaging, we demonstrate that lack of ABCD1 function causes increased...... capillary flow heterogeneity in asymptom- atic hemizygotes predominantly in the white matter regions and developmental stages with the highest probability for conversion to cerebral disease. In subjects with ongoing inflammatory demyelination we observed a sequence of increased capillary flow hetero...

  16. CMR of microvascular obstruction and hemorrhage in myocardial infarction

    Directory of Open Access Journals (Sweden)

    Wu Katherine C

    2012-09-01

    Full Text Available Abstract Microvascular obstruction (MO or no-reflow phenomenon is an established complication of coronary reperfusion therapy for acute myocardial infarction. It is increasingly recognized as a poor prognostic indicator and marker of subsequent adverse LV remodeling. Although MO can be assessed using various imaging modalities including electrocardiography, myocardial contrast echocardiography, nuclear scintigraphy, and coronary angiography, evaluation by cardiovascular magnetic resonance (CMR is particularly useful in enhancing its detection, diagnosis, and quantification, as well as following its subsequent effects on infarct evolution and healing. MO assessment has become a routine component of the CMR evaluation of acute myocardial infarction and will increasingly play a role in clinical trials of adjunctive reperfusion agents and strategies. This review will summarize the pathophysiology of MO, current CMR approaches to diagnosis, clinical implications, and future directions needed for improving our understanding of this common clinical problem.

  17. Clustering of microvascular complications in Type 1 diabetes mellitus

    DEFF Research Database (Denmark)

    Bjerg, Lasse; Hulman, Adam; Charles, Morten

    2018-01-01

    AIMS: To describe to what extent microvascular complications exhibit clustering in persons with Type 1 diabetes, and to assess whether the presence of one complication modified the strength of the association between the other two. METHODS: We conducted a cross-sectional analysis of the electronic...... medical records of 2276 persons with Type 1 diabetes treated in a specialized care hospital in Denmark in 2013. We used log-linear analysis to describe associations between diabetic kidney disease, neuropathy and retinopathy and logistic regression models to quantify the magnitude of associations...... adjusting for potential confounders. RESULTS: The median duration of diabetes was 24 years and median HbA1c was 63 mmol/mol (7.9%). We found strong indication of clustering and found no evidence that presence of one complication modified the association between the other two. In models adjusted for diabetes...

  18. Statin use before diabetes diagnosis and risk of microvascular disease

    DEFF Research Database (Denmark)

    Nielsen, Sune F; Nordestgaard, Børge G

    2014-01-01

    BACKGROUND: The role of statins in the development of microvascular disease in patients with diabetes is unknown. We tested the hypothesis that statin use increases the risk of diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, and gangrene of the foot in individuals with diabetes...... the cumulative incidence of diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, or gangrene of the foot in statin users versus non-statin users. We analysed data with Cox regression models, adjusted for covariates including sex, age at diabetes diagnosis, and method of diabetes diagnosis. To address...... diabetic neuropathy, 1248 developed diabetic nephropathy, and 2392 developed gangrene of the foot. Compared with non-statin users, statin users had a lower cumulative incidence of diabetic retinopathy (hazard ratio 0·60, 95% CI 0·54-0·66; pdiabetic neuropathy (0·66, 0·57-0·75; p

  19. Videojuegos en redes sociales: aprender desde experiencias óptimas

    OpenAIRE

    Esnaola Horacek, Graciela; Levis, Diego

    2009-01-01

    Desarrollaremos conceptos de interés académico acerca de las posibilidades educativas que actualmente ofrecen los entornos lúdicos en la Web 2.0, capturando el interés generalizado de los estudiantes. Destacaremos una definición particular de videojuego aplicando determinadas categorías de análisis a las propuestas lúdicas que ofrecen las redes sociales, en especial el caso Facebook. La línea que destacamos durante nuestra trayectoria de investigación se ubica en los entrecruzamientos que ...

  20. Smart cities, smart lights. Digital signane y experiencia urbana

    OpenAIRE

    Flore, Giovanni; Pozzoni, Alfio

    2012-01-01

    Este artículo aborda la experiencia lumínica en la ciudad inteligente y digital o, dicho de otro modo, el uso, cada vez mayor, de la digital signane visual en el entorno urbano, al aire libre y en lugares públicos. La investigación se centra en las áreas de la ciudad donde esta "contaminación" digital goza de mayor visibilidad y accesibilidad, es decir, las zonas comerciales.

  1. Immediate pain relief by microvascular decompression for idiopathic trigeminal neuralagia

    International Nuclear Information System (INIS)

    Haq, N.U.; Ali, M.; Khan, H.M.; Ishaq, M.; Khattak, M.I.

    2016-01-01

    Background: Trigeminal neuralgia is a common entity which is managed by neurosurgeons in day to day practice. Up-till now many treatment options have been adopted for it but micro-vascular decompression is much impressive in terms of pain control and recurrence rate in all of them. The objective of study was known the efficacy of micro vascular decompression for idiopathic trigeminal neuralgia by using muscle patch in terms of immediate pain relief. Methods: This descriptive study was carried out in Neurosurgery Department lady reading hospital, Peshawar from January 2010 to December 2012. All patients who underwent micro vascular decompression for idiopathic trigeminal neuralgia were included in the study. Patients were assessed 72 hours after the surgery by borrow neurological institute pain scale (BNIP scale) for pain relief and findings were documented on predesigned proforma. Data was analysed by SPSS-17. Results: Total 52 patients were included in this study. Among these 32 (61.53 percentage) were female and 20 (38.46 percentage) were males having age from 22-76 years (mean 49 years). Right side was involved in 36 (69.23 percentage) and left side in 16 (30.76 percentage) patients. Duration of symptoms ranged from 6 months to 16 years (mean 8 years). History of dental extraction and peripheral neurectomy was present in 20 (38 percentage) and 3(5.76 percentage) patients while V3 was most commonly involved branch with 28(57.69 percentage) frequency and combined V2,V3 involvement was 1 (11.53 percentage). Superior cerebellar artery was most common offending vessel in 46(88.46 percentage) while arachnoid adhesions were in 2(3.84 percentage) patients. We assessed patient immediate postoperatively using BNIP pain scale. Conclusion: Micro-vascular decompression is most effective mode of treatment for trigeminal neuralgia in terms of immediate pain relief. (author)

  2. La Naturaleza de la Experiencia Estética

    Directory of Open Access Journals (Sweden)

    George Herbert Mead

    2001-04-01

    Full Text Available El texto que presentamos en este número de Athenea Digital es "La Naturaleza de la Experiencia Estética" escrito por G.H.Mead en 1926, traducido e introducido por Estaban Laso y Anna Vitores. Como los mismos traductores explican en la introducción que precede al texto de Mead: El artículo ?La Naturaleza de la Experiencia Estética? (1926 que presentamos en este mismo número ?y que como la inmensa mayoría de los escritos de Mead es muy breve? se inscribe dentro de la orientación hacia la crítica cultural de su obra tardía. En tanto que parte de la brecha entre la esfera instrumental y la de los valores que caracteriza a la actividad y al pensamiento humano en la sociedad moderna, ofrece una buena oportunidad para pensar acerca de la tensión meadiana entre creatividad y normatividad. Y quizás también, para ir más allá y reflexionar sobre la tensión entre cambio y reproducción social, y sobre las formas en que podríamos ofrecer un concepto de acción y de experiencia no individualistas que permitieran articular esta tensión.

  3. Museos construidos y reconstruidos. Experiencias educativas para la creatividad

    Directory of Open Access Journals (Sweden)

    Romina Elisondo

    2015-09-01

    Full Text Available Los museos son espacios educativos promisorios para el aprendizaje y la creatividad. En el artículo contamos experiencias vinculadas a la construcción de propuestas educativas en museos, entendidos como construcciones sociales. Específicamente, nos referimos a dos propuestas educativas: un museo construido en el aula y una visita a un museo fuera del aula. Nos interesa describir las propuestas desarrolladas haciendo especial hincapié en las percepciones y valoraciones de los estudiantes respecto de las potencialidades educativas de los museos. Participaron de las experiencias estudiantes de las carreras de Licenciatura en Psicopedagogía y Educación Especial de la Universidad Nacional de Río Cuarto. Los museos, construidos y visitados, generan espacios para aprender y vivenciar experiencias significativas de aprendizaje. También se observan impactos positivos de los museos en la promoción de la creatividad y el desarrollo de innovaciones educativas. Historias personales, grupales y sociales circulan por los museos configurando entornos propicios para construir conocimientos dentro y fuera de las aulas.

  4. La enseñanza de la informática jurídica en nuestra Facultad de Derecho: estrategias didácticas

    OpenAIRE

    María José Viega Rodríguez

    2014-01-01

    Para analizar las estrategias didácticas en una materia nueva, como lo es en nuestra Facultad la Informática Jurídica, creo en primer lugar conveniente establecer su contenido, especificar su objeto y establecer el método apropiado.(...)Contenido: Métodos y técnicas didácticas. Recursos didácticos. Calificación automática. Conclusión

  5. Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet

    NARCIS (Netherlands)

    van Haare, Judith; Kooi, M. Eline; Vink, Hans; Post, Mark J.; van Teeffelen, Jurgen W. G. E.; Slenter, Jos; Munts, Chantal; Cobelens, Hanneke; Strijkers, Gustav J.; Koehn, Dennis; van Bilsen, Marc

    2015-01-01

    It remains to be established if, and to what extent, the coronary microcirculation becomes compromised during the development of obesity and insulin resistance. Recent studies suggest that changes in endothelial glycocalyx properties contribute to microvascular dysfunction under (pre-)diabetic

  6. Targeting the dominant mechanism of coronary microvascular dysfunction with intracoronary physiology tests

    NARCIS (Netherlands)

    Mejia-Renteria, H.; Hoeven, N. van der; Hoef, T.P. van de; Heemelaar, J.; Ryan, N.; Lerman, A.; Royen, N. van; Escaned, J.

    2017-01-01

    The coronary microcirculation plays a key role in modulating blood supply to the myocardium. Several factors like myocardial oxygen demands, endothelial and neurogenic conditions determine its function. Although there is available evidence supporting microvascular dysfunction as an important cause

  7. Insulin-resistant glucose metabolism in patients with microvascular angina--syndrome X

    DEFF Research Database (Denmark)

    Vestergaard, H; Skøtt, P; Steffensen, R

    1995-01-01

    Studies in patients with microvascular angina (MA) or the cardiologic syndrome X have shown a hyperinsulinemic response to an oral glucose challenge, suggesting insulin resistance and a role for increased serum insulin in coronary microvascular dysfunction. The aim of the present study was to exa......Studies in patients with microvascular angina (MA) or the cardiologic syndrome X have shown a hyperinsulinemic response to an oral glucose challenge, suggesting insulin resistance and a role for increased serum insulin in coronary microvascular dysfunction. The aim of the present study...... was to examine whether patients with MA are insulin-resistant. Nine patients with MA and seven control subjects were studied. All were sedentary and glucose-tolerant. Coronary arteriography was normal in all participants, and exercise-induced coronary ischemia was demonstrated in all MA patients. A euglycemic...... metabolism (8.4 +/- 0.9 v 12.5 +/- 1.3 mg.kg FFM-1.min-1, P

  8. [Construction of 2-dimensional tumor microvascular architecture phenotype in non-small cell lung cancer].

    Science.gov (United States)

    Liu, Jin-kang; Wang, Xiao-yi; Xiong, Zeng; Zhou, Hui; Zhou, Jian-hua; Fu, Chun-yan; Li, Bo

    2008-08-01

    To construct a technological platform of 2-dimensional tumor microvascular architecture phenotype (2D-TAMP) expression. Thirty samples of non-small cell lung cancer (NSCLC) were collected after surgery. The corresponding sections of tumor tissue specimens to the slice of CT perfusion imaging were selected. Immunohistochemical staining,Gomori methenamine silver stain, and electron microscope observation were performed to build a technological platform of 2D-TMAP expression by detecting the morphology and the integrity of basement membrane of microvasculature, microvascular density, various microvascular subtype, the degree of the maturity and lumenization of microvasculature, and the characteristics of immunogenetics of microvasculature. The technological platform of 2D-TMAP expression was constructed successfully. There was heterogeneity in 2D-TMAP expression of non-small cell lung cancer. The microvascular of NSCLC had certain characteristics. 2D-TMAP is a key technology that can be used to observe the overall state of micro-environment in tumor growth.

  9. VEGF expression and microvascular density in relation to high-risk ...

    African Journals Online (AJOL)

    Bassma M. El Sabaa

    2012-01-13

    Jan 13, 2012 ... Eleven cases were low grade and 19 were high-grade cases. VEGF expression .... increasing microvascular permeability,26 degradation of extra- ...... soluble receptors in pre-invasive, invasive and recurrent cervical cancer.

  10. Sujetos por su resistencia. Análisis sociológico de una experiencia de trabajo bajo el sistema de producción por micromovimientos

    Directory of Open Access Journals (Sweden)

    Francisco José León Medina

    2008-01-01

    Full Text Available En este artículo presentamos el análisis de una experiencia de trabajo bajo el sistema de producción por micromovimientos (MTM. Este análisis puede ayudarnos a arrojar algo de luz sobre el enigma de cómo y por qué sostenemos con nuestra acción, en determinados contextos, relaciones de sometimiento que experimentamos como hirientes y a las que no reconocemos legitimidad. Defenderemos la tesis de que la especial combinación de compromiso y resistencia ante la producción que desarrollan los trabajadores les constituye como "sujetos" del vínculo productivo, en la medida en que en esa combinación desarrollan y expresan su sentido de la autonomía y de la propia dignidad y respeto. Pero, al mismo tiempo, veremos cómo esa resistencia los sujeta al sometimiento, ya que hace posible y eficiente el orden productivo. Al menos en este caso, si los trabajadores sostienen un vínculo hiriente es porque sus acciones tienen lugar en una auténtica jaula de hierro en la que su dignidad se ha convertido en uno de los pilares básicos de su sometimiento.

  11. Interactions of the gasotransmitters contribute to microvascular tone (dysregulation in the preterm neonate.

    Directory of Open Access Journals (Sweden)

    Rebecca M Dyson

    Full Text Available Hydrogen sulphide (H2S, nitric oxide (NO, and carbon monoxide (CO are involved in transitional microvascular tone dysregulation in the preterm infant; however there is conflicting evidence on the interaction of these gasotransmitters, and their overall contribution to the microcirculation in newborns is not known. The aim of this study was to measure the levels of all 3 gasotransmitters, characterise their interrelationships and elucidate their combined effects on microvascular blood flow.90 preterm neonates were studied at 24h postnatal age. Microvascular studies were performed by laser Doppler. Arterial COHb levels (a measure of CO were determined through co-oximetry. NO was measured as nitrate and nitrite in urine. H2S was measured as thiosulphate by liquid chromatography. Relationships between levels of the gasotransmitters and microvascular blood flow were assessed through partial correlation controlling for the influence of gestational age. Structural equation modelling was used to examine the combination of these effects on microvascular blood flow and derive a theoretical model of their interactions.No relationship was observed between NO and CO (p = 0.18, r = 0.18. A positive relationship between NO and H2S (p = 0.008, r = 0.28 and an inverse relationship between CO and H2S (p = 0.01, r = -0.33 exists. Structural equation modelling was used to examine the combination of these effects on microvascular blood flow. The model with the best fit is presented.The relationships between NO and H2S, and CO and H2S may be of importance in the preterm newborn, particularly as NO levels in males are associated with higher H2S levels and higher microvascular blood flow and CO in females appears to convey protection against vascular dysregulation. Here we present a theoretical model of these interactions and their overall effects on microvascular flow in the preterm newborn, upon which future mechanistic studies may be based.

  12. Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization.

    Science.gov (United States)

    Ladwiniec, Andrew; Cunnington, Michael S; Rossington, Jennifer; Thackray, Simon; Alamgir, Farquad; Hoye, Angela

    2016-05-01

    The aim of this study was to compare microvascular resistance under both baseline and hyperemic conditions immediately after percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) with an unobstructed reference vessel in the same patient Microvascular dysfunction has been reported to be prevalent immediately after CTO PCI. However, previous studies have not made comparison with a reference vessel. Patients with a CTO may have global microvascular and/or endothelial dysfunction, making comparison with established normal values misleading. After successful CTO PCI in 21 consecutive patients, coronary pressure and flow velocity were measured at baseline and hyperemia in distal segments of the CTO/target vessel and an unobstructed reference vessel. Hemodynamics including hyperemic microvascular resistance (HMR), basal microvascular resistance (BMR), and instantaneous minimal microvascular resistance at baseline and hyperemia were calculated and compared between reference and target/CTO vessels. After CTO PCI, BMR was reduced in the target/CTO vessel compared with the reference vessel: 3.58 mm Hg/cm/s vs 4.94 mm Hg/cm/s, difference -1.36 mm Hg/cm/s (-2.33 to -0.39, p = 0.008). We did not detect a difference in HMR: 1.82 mm Hg/cm/s vs 2.01 mm Hg/cm/s, difference -0.20 (-0.78 to 0.39, p = 0.49). Instantaneous minimal microvascular resistance correlated strongly with the length of stented segment at baseline (r = 0.63, p = 0.005) and hyperemia (r = 0.68, p = 0.002). BMR is reduced in a recanalized CTO in the immediate aftermath of PCI compared to an unobstructed reference vessel; however, HMR appears to be preserved. A longer stented segment is associated with increased microvascular resistance. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. GM-CSF ameliorates microvascular barrier integrity via pericyte-derived Ang-1 in wound healing.

    Science.gov (United States)

    Yan, Min; Hu, Yange; Yao, Min; Bao, Shisan; Fang, Yong

    2017-11-01

    Skin wound healing involves complex coordinated interactions of cells, tissues, and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound-area, postinjury. Eventually, vessel integrity has to be reestablished for vascular maturation. Numerous studies have found that granulocyte macrophage colony-stimulating factor (GM-CSF) accelerates wound healing by inducing recruitment of repair cells into the injury area and releases of cytokines. However, whether GM-CSF is involving in the maintaining of microvascular barrier integrity and the underlying mechanism remain still unclear. Aim of this study was to investigate the effects of GM-CSF on modulation of microvascular permeability in wound healing and underlying mechanisms. Wound closure and microvascular leakage was investigated using a full-thickness skin wound mouse model after GM-CSF intervention. The endothelial permeability was measured by Evans blue assay in vivo and in vitro endothelium/pericyte co-culture system using a FITC-Dextran permeability assay. To identify the source of angiopoietin-1 (Ang-1), double staining is used in vivo and ELISA and qPCR are used in vitro. To determine the specific effect of Ang-1 on GM-CSF maintaining microvascular stabilization, Ang-1 siRNA was applied to inhibit Ang-1 production in vivo and in vitro. Wound closure was significantly accelerated and microvascular leakage was ameliorated after GM-CSF treatment in mouse wound sites. GM-CSF decreased endothelial permeability through tightening endothelial junctions and increased Ang-1 protein level that was derived by perictye. Furthermore, applications of siRNAAng-1 inhibited GM-CSF mediated protection of microvascular barrier integrity both in vivo and in vitro. Our data indicate that GM

  14. Improved myocardial perfusion after transmyocardial laser revascularization in a patient with microvascular coronary artery disease

    Directory of Open Access Journals (Sweden)

    Peyman Mesbah Oskui

    2014-03-01

    Full Text Available We report the case of a 59-year-old woman who presented with symptoms of angina that was refractory to medical management. Although her cardiac catheterization revealed microvascular coronary artery disease, her symptoms were refractory to optimal medical management that included ranolazine. After undergoing transmyocardial revascularization, her myocardial ischemia completely resolved and her symptoms dramatically improved. This case suggests that combination of ranolazine and transmyocardial revascularization can be applied to patients with microvascular coronary artery disease.

  15. Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?

    Science.gov (United States)

    Borges, Juliana Pereira; Mendes, Fernanda de Souza Nogueira Sardinha; Lopes, Gabriella de Oliveira; Sousa, Andréa Silvestre de; Mediano, Mauro Felippe Felix; Tibiriçá, Eduardo

    2018-08-15

    Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease. Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh). Peak increase in forearm blood flow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4% vs. ischemic heart disease: 74.1 ± 48.3% and Chagas: 85.1 ± 68.1%; p < 0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin blood flow (p = 0.55). Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy. Copyright © 2018 Elsevier B.V. All rights reserved.

  16. Coherence and Coupling Functions Reveal Microvascular Impairment in Treated Hypertension

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    Valentina Ticcinelli

    2017-10-01

    Full Text Available The complex interactions that give rise to heart rate variability (HRV involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling parameters underlying cardiac, respiratory and vascular regulation have been investigated at both the central and microvascular levels. Hypertension was considered as an example of a globally altered state of the complex dynamics of the cardiovascular system. Its effects were established through analysis of simultaneous recordings of the electrocardiogram (ECG, respiratory effort, and microvascular blood flow [by laser Doppler flowmetry (LDF]. The signals were analyzed by methods developed to capture time-dependent dynamics, including the wavelet transform, wavelet-based phase coherence, non-linear mode decomposition, and dynamical Bayesian inference, all of which can encompass the inherent frequency and coupling variability of living systems. Phases of oscillatory modes corresponding to the cardiac (around 1.0 Hz, respiratory (around 0.25 Hz, and vascular myogenic activities (around 0.1 Hz were extracted and combined into two coupled networks describing the central and peripheral systems, respectively. The corresponding spectral powers and coupling functions were computed. The same measurements and analyses were performed for three groups of subjects: healthy young (Y group, 24.4 ± 3.4 y, healthy aged (A group, 71.1 ± 6.6 y, and aged treated hypertensive patients (ATH group, 70.3 ± 6.7 y. It was established that the degree of coherence between low-frequency oscillations near 0.1 Hz in blood flow and in HRV time series differs markedly between the groups, declining with age and nearly disappearing in treated hypertension. Comparing the two healthy groups it was found that the couplings to the cardiac rhythm from both respiration and

  17. In vitro analysis of human periodontal microvascular endothelial cells.

    Science.gov (United States)

    Tsubokawa, Mizuki; Sato, Soh

    2014-08-01

    Endothelial cells (ECs) participate in key aspects of vascular biology, such as maintenance of capillary permeability, initiation of coagulation, and regulation of inflammation. According to previous reports, ECs have revealed highly specific characteristics depending on the organs and tissues. However, some reports have described the characteristics of the capillaries formed by human periodontal ECs. Therefore, the aim of the present study is to examine the functional characteristics of the periodontal microvascular ECs in vitro. Human periodontal ligament-endothelial cells (HPDL-ECs) and human gingiva-endothelial cells (HG-ECs) were isolated by immunoprecipitation with magnetic beads conjugated to a monoclonal anti-CD31 antibody. The isolated HPDL-ECs and HG-ECs were characterized to definitively demonstrate that these cell cultures represented pure ECs. Human umbilical-vein ECs and human dermal microvascular ECs were used for comparison. These cells were compared according to the proliferation potential, the formation of capillary-like tubes, the transendothelial electric resistance (TEER), and the expression of tight junction proteins. HPDL-ECs and HG-ECs with characteristic cobblestone monolayer morphology were obtained, as determined by light microscopy at confluence. Furthermore, the HPDL-ECs and HG-ECs expressed the EC markers platelet endothelial cell adhesion molecule-1 (also known as CD31), von Willebrand factor, and Ulex europaeus agglutinin 1, and the cells stained strongly positive for CD31 and CD309. In addition, the HPDL-ECs and HG-ECs were observed to form capillary-like tubes, and they demonstrated uptake of acetylated low-density lipoprotein. Functional analyses of the HPDL-ECs and HG-ECs showed that, compared to the control cells, tube formation persisted for only a brief period of time, and TEER was substantially reduced at confluence. Furthermore, the cells exhibited delocalization of zonula occludens-1 and occludin at cell-cell contact sites

  18. EXPERIENCIAS DE GUERRA DESDE LA VOZ DE LAS MUJERES

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    Elsa Blair

    2003-01-01

    Full Text Available El articulo recoge algunas reflexiones en tormo al trabajode campo realizado con mujeres excombatientes de diversos grupos armados colombianos en el marco de la investigación Mujeres en tiempos de guerra: una mirada a lo femenino en el contexto de los grupos armados colombianos. A partir de una concepción de la guerra como construcción cultural, las autoras interrogan los efectos de la misma sobre su identidad femenina, esto es, lo que la guerra ha representado para ellas como mujeres y los efectos que ha tenido en términos de su identidad genérica. Tras una reflexión inicia en torno a los desafíos éticos planteados por el trabajo de campo, las autoras abordan la problemática de la identidad de género a través de dos vías: por una parte, los campos o "nudos¿ temáticos que amarran las narraciones de mujeres entrevistadas -la familia, la maternidad y los hijos, las relaciones con los "otros", las experiencias de muerte y el dolor de la guerra-; y por otra, la forma particular en que ellas construyen sus relatos sobre su experiencia como combatientes. Por último, a partir de esa mirada analítica sobre la manera como estas mujeres han vivido y significado su experiencia como guerreras, las autoras plantean, algunas conclusiones preliminares en torno a dicha problemática.

  19. Equipos docentes : experiencias y resultados (2013-2014)

    OpenAIRE

    Herrero Martín, Ruth; García Martín, Antonio

    2014-01-01

    Los equipos docentes son grupos de trabajo constituidos al amparo del Programa de Redes de Investigación en Docencia Universitaria (2009-2010) de la UPCT y dedicados a reflexionar sobre distintos aspectos de la actividad docente, a intercambiar experiencias y a mejorar la praxis docente de sus integrantes. Este libro recoge el trabajo desarrollado por los equipos docentes durante el curso 2013-2014. Una parte significativa de ese trabajo se orienta a la mejora de la calidad docente y, en el c...

  20. La intimidad y la experiencia en lo público

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    María Teresa Luna

    2007-05-01

    Full Text Available Esta investigación, de corte fenomenológico, se posiciona en los postulados de la fenomenología del mundo social desarrollada por Alfred Schütz; en este sentido se discute la categoría intimidad como experiencia subjetiva en la que se vivencia la configuración del yo y el tú, y en la que se producen y decantan significaciones esenciales para la relación con uno mismo o con una misma, y con los otros u otras, lo cual parece producir esquemas de actuación en lo público, entendido como el espacio físico y simbólico compartido con otros mediatos u otras mediatas. La información fue construida mediante entrevistas conversacionales en las que cuatro profesionales (tres mujeres y un hombre, vinculados a Organizaciones No Gubernamentales de la ciudad de Medellín con un fuerte trabajo en lo público, construyeron narrativas autobiográficas. La unidad de lectura de la información fue el relato –entendido como una historia con un principio, un desarrollo y un final–y el criterio de selección de relatos significativos fue el acontecimiento biográfico, entendido como un evento que produce un quiebre en la propia biografía, sea porque rompe algo o inaugura algo. Los acontecimientos seleccionados fueron aquellos que aportaban información pertinente para comprender la progresiva configuración de la experiencia íntima y su encadenamiento con una cierta forma de experienciar la actuación en lo público. Los resultados muestran que la intimidad es experiencia de posicionamiento en asuntos morales que están en la base de la actuación en lo público, así como también que en las relaciones íntimas –básicamente con los contemporáneos inmediatos como los amigos, las amigas y las parejas– se construyen experiencias como la confianza, el cuidado y el respeto, que son determinantes en la manera de transitar por la esfera pública.

  1. La intimidad y la experiencia en lo público

    Directory of Open Access Journals (Sweden)

    María Teresa Luna C.

    2007-01-01

    Full Text Available Esta investigación, de corte fenomenológico, se posiciona en los postulados de la fenomenología del mundo social desarrollada por Alfred Schütz; en este sentido se discute la categoría intimidad como experiencia subjetiva en la que se vivencia la configuración del yo y el tú, y en la que se producen y decantan significaciones esenciales para la relación con uno mismo o con una misma, y con los otros u otras, lo cual parece producir esquemas de actuación en lo público, entendido como el espacio físico y simbólico compartido con otros mediatos u otras mediatas. La información fue construida mediante entrevistas conversacionales en las que cuatro profesionales (tres mujeres y un hombre, vinculados a Organizaciones No Gubernamentales de la ciudad de Medellín con un fuerte trabajo en lo público, construyeron narrativas autobiográficas. La unidad de lectura de la información fue el relato –entendido como una historia con un principio, un desarrollo y un final–y el criterio de selección de relatos significativos fue el acontecimiento biográfico, entendido como un evento que produce un quiebre en la propia biografía, sea porque rompe algo o inaugura algo. Los acontecimientos seleccionados fueron aquellos que aportaban información pertinente para comprender la progresiva configuración de la experiencia íntima y su encadenamiento con una cierta forma de experienciar la actuación en lo público. Los resultados muestran que la intimidad es experiencia de posicionamiento en asuntos morales que están en la base de la actuación en lo público, así como también que en las relaciones íntimas –básicamente con los contemporáneos inmediatos como los amigos, las amigas y las parejas– se construyen experiencias como la confianza, el cuidado y el respeto, que son determinantes en la manera de transitar por la esfera pública.

  2. Experiencias divertidas de electroquímica casera

    OpenAIRE

    Santiago Heredia-Avalos

    2007-01-01

    La química, dentro de la cual se incluye la electroquímica, es una materia que los estudiantes suelen ver como complicada, aburrida, carente de interés y que, además requiere de material de laboratorio sofisticado y reactivos químicos inaccesibles. Nada más lejos de la realidad, tal y como se pondrá de manifiesto en este trabajo, donde se proponen varias experiencias sencillas usando sustancias baratas, la mayoría de las cuales pueden encontrarse en un supermercado, y utensilio...

  3. Literatura infantil para no lectores. Una experiencia desde la universidad

    OpenAIRE

    Ponce Naranjo, Genoveva

    2016-01-01

    La lectura es un tema de indiscutible importancia, como lo refiere Michèle Petit (1999, p. 19), “la lectura es tanto un medio para elaborar su subjetividad como un medio para acceder al conocimiento”; por eso, la experiencia académica con estudiantes de la Carrera de Ciencias Sociales de la Facultad de Ciencias de la Educación de la Universidad Nacional de Chimborazo,  tuvo como objetivo, resignificar  la lectura como práctica cotidiana, a través de una metodología cualitativa que apoyada en ...

  4. M-Learning - una experiencia colaborativa usando el Software Telegram

    OpenAIRE

    Salas, Marco Antonio; Salas Subía, Juan Carlos

    2018-01-01

    La presente experiencia de aprendizaje colaborativo presenta los resultados  obtenidos  mediante el uso dispositivos de telefonía móvil (Smartphone) cuyo uso se ha generalizado especialmente en la juventud y en consecuencia debe ser aprovechado dentro del ámbito educativo; junto a estos dispositivos se ha difundido el uso de herramientas de comunicación como el sistema mensajería  Telegram, del  que se ha tomado características que permiten  el fomento del aprendizaje...

  5. Experiencias exitosas de e- learning en la universidad gallega

    OpenAIRE

    Gromaz Campos, Manuel; Rodríguez Malmierca, María José; García Tobío, Javier

    2008-01-01

    Este artículo resume la información obtenida en el marco de un proyecto de investigación, denominado "Observatorio gallego de e-learning". Dicha investigación fue dirigida por el Centro de Supercomputación de Galicia, con la participación activa de las tres universidades gallegas. Su principal objetivo fue realizar un análisis en profundidad sobre el estado del e-learning tanto en la universidad como en la empresa gallegas. Entre los elementos analizados, se encuentran algunas experiencias qu...

  6. Cardiac microvascular endothelial cells express a functional Ca+ -sensing receptor.

    Science.gov (United States)

    Berra Romani, Roberto; Raqeeb, Abdul; Laforenza, Umberto; Scaffino, Manuela Federica; Moccia, Francesco; Avelino-Cruz, Josè Everardo; Oldani, Amanda; Coltrini, Daniela; Milesi, Veronica; Taglietti, Vanni; Tanzi, Franco

    2009-01-01

    The mechanism whereby extracellular Ca(2+) exerts the endothelium-dependent control of vascular tone is still unclear. In this study, we assessed whether cardiac microvascular endothelial cells (CMEC) express a functional extracellular Ca(2+)-sensing receptor (CaSR) using a variety of techniques. CaSR mRNA was detected using RT-PCR, and CaSR protein was identified by immunocytochemical analysis. In order to assess the functionality of the receptor, CMEC were loaded with the Ca(2+)-sensitive fluorochrome, Fura-2/AM. A number of CaSR agonists, such as spermine, Gd(3+), La(3+) and neomycin, elicited a heterogeneous intracellular Ca(2+) signal, which was abolished by disruption of inositol 1,4,5-trisphosphate (InsP(3)) signaling and by depletion of intracellular stores with cyclopiazonic acid. The inhibition of the Na(+)/Ca(2+) exchanger upon substitution of extracellular Na(+) unmasked the Ca(2+) signal triggered by an increase in extracellular Ca(2+) levels. Finally, aromatic amino acids, which function as allosteric activators of CaSR, potentiated the Ca(2+) response to the CaSR agonist La(3+). These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores. Copyright 2008 S. Karger AG, Basel.

  7. Quantitative and qualitative retinal microvascular characteristics and blood pressure.

    Science.gov (United States)

    Cheung, Carol Y; Tay, Wan T; Mitchell, Paul; Wang, Jie J; Hsu, Wynne; Lee, Mong L; Lau, Qiangfeng P; Zhu, Ai L; Klein, Ronald; Saw, Seang M; Wong, Tien Y

    2011-07-01

    The present study examined the effects of blood pressure on a spectrum of quantitative and qualitative retinal microvascular signs. Retinal photographs from the Singapore Malay Eye Study, a population-based cross-sectional study of 3280 (78.7% response) persons aged 40-80 years, were analyzed. Quantitative changes in the retinal vasculature (branching angle, vascular tortuosity, fractal dimension, and vascular caliber) were measured using a semi-automated computer-based program. Qualitative signs, including focal arteriolar narrowing (FAN), arteriovenous nicking (AVN), opacification of the arteriolar wall (OAW), and retinopathy (e.g., microaneurysms, retinal hemorrhages), were assessed from photographs by trained technicians. After excluding persons with diabetes and ungradable photographs, 1913 persons provided data for this analysis. In multivariable linear regression models controlling for age, sex, BMI, use of antihypertensive medication, and other factors, retinal arteriolar branching asymmetry ratio, arteriolar tortuosity, venular tortuosity, fractal dimension, arteriolar caliber, venular caliber, FAN, AVN, and retinopathy were independently associated with mean arterial blood pressure. In contrast, arteriolar/venular branching angle, venular branching asymmetry ratio and OAW were not related to blood pressure. Retinal arteriolar caliber (sβ = -0.277) and FAN (sβ = 0.170) had the strongest associations with mean arterial blood pressure, and higher blood pressure levels were associated with increasing number of both quantitative and qualitative retinal vascular signs (P trend qualitative retinal vascular signs, with the number of signs increasing with higher blood pressure levels.

  8. Comparison of tissue processing methods for microvascular visualization in axolotls.

    Science.gov (United States)

    Montoro, Rodrigo; Dickie, Renee

    2017-01-01

    The vascular system, the pipeline for oxygen and nutrient delivery to tissues, is essential for vertebrate development, growth, injury repair, and regeneration. With their capacity to regenerate entire appendages throughout their lifespan, axolotls are an unparalleled model for vertebrate regeneration, but they lack many of the molecular tools that facilitate vascular imaging in other animal models. The determination of vascular metrics requires high quality image data for the discrimination of vessels from background tissue. Quantification of the vasculature using perfused, cleared specimens is well-established in mammalian systems, but has not been widely employed in amphibians. The objective of this study was to optimize tissue preparation methods for the visualization of the microvascular network in axolotls, providing a basis for the quantification of regenerative angiogenesis. To accomplish this aim, we performed intracardiac perfusion of pigment-based contrast agents and evaluated aqueous and non-aqueous clearing techniques. The methods were verified by comparing the quality of the vascular images and the observable vascular density across treatment groups. Simple and inexpensive, these tissue processing techniques will be of use in studies assessing vascular growth and remodeling within the context of regeneration. Advantages of this method include: •Higher contrast of the vasculature within the 3D context of the surrounding tissue •Enhanced detection of microvasculature facilitating vascular quantification •Compatibility with other labeling techniques.

  9. Cardiac microvascular rarefaction in hyperthyroidism-induced left ventricle dysfunction.

    Science.gov (United States)

    Freitas, Felipe; Estato, Vanessa; Carvalho, Vinícius Frias; Torres, Rafael Carvalho; Lessa, Marcos Adriano; Tibiriçá, Eduardo

    2013-10-01

    The pathophysiology underlying hyperthyroidism-induced left ventricle (LV) dysfunction and hypertrophy directly involves the heart and indirectly involves the neuroendocrine systems. The effects of hyperthyroidism on the microcirculation are still controversial in experimental models. We investigated the effects of hyperthyroidism on the cardiac function and microcirculation of an experimental rat model. Male Wistar rats (170-250 g) were divided into two groups: the euthyroid group (n = 10), which was treated with 0.9% saline solution, and the hyperthyroid group (n = 10), which was treated with l-thyroxine (600 μg/kg/day, i.p.) during 14 days. An echocardiographic study was performed to evaluate the alterations in cardiac function, structure and geometry. The structural capillary density and the expression of angiotensin II AT1 receptor in the LV were analyzed using histochemistry and immunohistochemistry, respectively. Hyperthyroidism was found to induce profound cardiovascular alterations, such as systolic hypertension, tachycardia, LV dysfunction, cardiac hypertrophy, and myocardial fibrosis. This study demonstrates the existence of structural capillary rarefaction and the down-regulation of the cardiac angiotensin II AT1 receptor in the myocardium of hyperthyroid rats in comparison with euthyroid rats. Microvascular rarefaction may be involved in the pathophysiology of hyperthyroidism-induced cardiovascular alterations. © 2013 John Wiley & Sons Ltd.

  10. Biomarker for early renal microvascular and diabetic kidney diseases.

    Science.gov (United States)

    Futrakul, Narisa; Futrakul, Prasit

    2017-11-01

    Recognition of early stage of diabetic kidney disease, under common practice using biomarkers, namely microalbuminuria, serum creatinine level above 1 mg/dL and accepted definition of diabetic kidney disease associated with creatinine clearance value below 60 mL/min/1.73 m 2 , is unlikely. This would lead to delay treatment associated with therapeutic resistance to vasodilator due to a defective vascular homoeostasis. Other alternative biomarkers related to the state of microalbuminuria is not sensitive to screen for early diabetic kidney disease (stages I, II). In this regard, a better diagnostic markers to serve for this purpose are creatinine clearance, fractional excretion of magnesium (FE Mg), cystatin C. Recently, renal microvascular disease and renal ischemia have been demonstrated to correlate indirectly with the development of diabetic kidney disease and its function. Among these are angiogenic and anti-angiogenic factors, namely VEGF, VEGF receptors, angiopoietins and endostatin. With respect to therapeutic prevention, implementation of treatment at early stage of diabetic and nondiabetic kidney disease is able to restore renal perfusion and function.

  11. Evolución del concepto de “Estrés Oxidativo”: medio siglo de aportes de nuestra Facultad.

    Directory of Open Access Journals (Sweden)

    Rafael Radi

    2014-12-01

    fenómenos oxidativos asociados a patología. He seleccionado observaciones y trabajos con énfasis bioquímico que considero relevantes a nivel universal, relacionándolos e integrándolos con aportes que se han realizado desde nuestra Facultad en el área de estrés oxidativo.

  12. Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study.

    Science.gov (United States)

    Kim, Dae Hyun; Grodstein, Francine; Newman, Anne B; Chaves, Paulo H M; Odden, Michelle C; Klein, Ronald; Sarnak, Mark J; Lipsitz, Lewis A

    2015-09-01

    To evaluate and compare the associations between microvascular and macrovascular abnormalities and cognitive and physical function Cross-sectional analysis of the Cardiovascular Health Study (1998-1999). Community. Individuals with available data on three or more of five microvascular abnormalities (brain, retina, kidney) and three or more of six macrovascular abnormalities (brain, carotid artery, heart, peripheral artery) (N = 2,452; mean age 79.5). Standardized composite scores derived from three cognitive tests (Modified Mini-Mental State Examination, Digit-Symbol Substitution Test, Trail-Making Test (TMT)) and three physical tests (gait speed, grip strength, 5-time sit to stand) Participants with high microvascular and macrovascular burden had worse cognitive (mean score difference = -0.30, 95% confidence interval (CI) = -0.37 to -0.24) and physical (mean score difference = -0.32, 95% CI = -0.38 to -0.26) function than those with low microvascular and macrovascular burden. Individuals with high microvascular burden alone had similarly lower scores than those with high macrovascular burden alone (cognitive function: -0.16, 95% CI = -0.24 to -0.08 vs -0.13, 95% CI = -0.20 to -0.06; physical function: -0.15, 95% CI = -0.22 to -0.08 vs -0.12, 95% CI = -0.18 to -0.06). Psychomotor speed and working memory, assessed using the TMT, were only impaired in the presence of high microvascular burden. Of the 11 vascular abnormalities considered, white matter hyperintensity, cystatin C-based glomerular filtration rate, large brain infarct, and ankle-arm index were independently associated with cognitive and physical function. Microvascular and macrovascular abnormalities assessed using noninvasive tests of the brain, kidney, and peripheral artery were independently associated with poor cognitive and physical function in older adults. Future research should evaluate the usefulness of these tests in prognostication. © 2015, Copyright the Authors Journal compilation © 2015

  13. Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion.

    Science.gov (United States)

    Zirak, Peyman; Delgado-Mederos, Raquel; Dinia, Lavinia; Martí-Fàbregas, Joan; Durduran, Turgut

    2014-02-01

    In patients with severe internal carotid artery steno-occlusive lesions (ISOL), impaired cerebrovascular reactivity (CVR) is predictive of future ischemic stroke (IS) or transient ischemic attack (TIA). Therefore, the evaluation of CVR in ISOL patients may be a means to evaluate the risk for IS/TIA and decide on an intervention. Our aim was (1) to explore the feasibility of concurrent near-infrared spectroscopy (NIRS-DOS), diffuse correlation spectroscopy, and transcranial Doppler for CVR assessment in ISOL patients, and (2) to compare macrovascular and microvascular CVR in ISOL patients and explore its potential for IS/TIA risk stratification. Twenty-seven ISOL patients were recruited. The changes in continuous microvascular and macrovascular hemodynamics upon acetazolamide injection were used to determine CVR. Oxyhemoglobin (HbO2, by near-infrared spectroscopy), microvascular cerebral blood flow (CBF, by diffuse correlation spectroscopy) and CBF velocity (by transcranial Doppler) showed significant increases upon acetazolamide injection in all subjects (P < .03). Only macrovascular CVR (P = .024) and none of the microvascular measures were significantly dependent on the presence of ISOL. In addition, while CBF was significantly correlated with HbO2, neither of these microvascular measures correlated with macrovascular CBF velocity. We demonstrated the simultaneous, continuous, and noninvasive evaluation of CVR at both the microvasculature and macrovasculature. We found that macrovascular CVR response depends on the presence of ISOL, whereas the microvascular CVR did not significantly depend on the ISOL presence, possibly due to the role of collaterals other than those of the circle of Willis. The concurrent microvascular and macrovascular CVR measurement in the ISOL patients might improve future IS/TIA risk assessment. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

  14. Transfer of Learning from Practicing Microvascular Anastomosis on Silastic Tubes to Rat Abdominal Aorta.

    Science.gov (United States)

    Mokhtari, Pooneh; Tayebi Meybodi, Ali; Lawton, Michael T; Payman, Andre; Benet, Arnau

    2017-12-01

    Learning to perform microvascular anastomosis is difficult. Laboratory practice models using artificial vessels are frequently used for this purpose. However, the efficacy of such practice models has not been objectively assessed for the performance of microvascular anastomosis during live surgical settings. This study was conducted to assess the transfer of learning from practicing microvascular anastomosis on tubes to anastomosing rat abdominal aorta. Ten surgeons without any experience in microvascular anastomosis were randomly assigned to an experimental or a control group. Both groups received didactic and visual training on end-to-end microvascular anastomosis. The experimental group received 24 sessions of hands-on training on microanastomosis using Silastic tubes. Next, both groups underwent recall tests on weeks 1, 2, and 8 after training. The recall test consisted of completing an end-to-end anastomosis on the rat's abdominal aorta. Anastomosis score, the time to complete the anastomosis, and the average time to place 1 stitch on the vessel perimeter were compared between the 2 groups. Compared with the control group, the experimental group did significantly better in terms of anastomosis score, total time, and per-stitch time. The measured variables showed stability and did not change significantly between the 3 recall tests. The skill of microvascular anastomosis is transferred from practicing on Silastic tubes to rat's abdominal aorta. Considering the relative advantages of Silastic tubes to live rodent surgeries, such as lower cost and absence of ethical issues, our results support the widespread use of Silastic tubes in training programs for microvascular anastomosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig.

    Science.gov (United States)

    Dyson, Rebecca M; Palliser, Hannah K; Lakkundi, Anil; de Waal, Koert; Latter, Joanna L; Clifton, Vicki L; Wright, Ian M R

    2014-09-17

    Dysfunction of the transition from fetal to neonatal circulatory systems may be a major contributor to poor outcome following preterm birth. Evidence exists in the human for both a period of low flow between 5 and 11 h and a later period of increased flow, suggesting a hypoperfusion-reperfusion cycle over the first 24 h following birth. Little is known about the regulation of peripheral blood flow during this time. The aim of this study was to conduct a comparative study between the human and guinea pig to characterize peripheral microvascular behavior during circulatory transition. Very preterm (≤28 weeks GA), preterm (29-36 weeks GA), and term (≥37 weeks GA) human neonates underwent laser Doppler analysis of skin microvascular blood flow at 6 and 24 h from birth. Guinea pig neonates were delivered prematurely (62 day GA) or at term (68-71 day GA) and laser Doppler analysis of skin microvascular blood flow was assessed every 2 h from birth. In human preterm neonates, there is a period of high microvascular flow at 24 h after birth. No period of low flow was observed at 6 h. In preterm animals, microvascular flow increased after birth, reaching a peak at 10 h postnatal age. Blood flow then steadily decreased, returning to delivery levels by 24 h. Preterm birth was associated with higher baseline microvascular flow throughout the study period in both human and guinea pig neonates. The findings do not support a hypoperfusion-reperfusion cycle in the microcirculation during circulatory transition. The guinea pig model of preterm birth will allow further investigation of the mechanisms underlying microvascular function and dysfunction during the initial extrauterine period. © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  16. El sentido político de nuestras prácticas. Una psicología de lo comunitario en movimiento

    Directory of Open Access Journals (Sweden)

    Lis Pérez

    2015-11-01

    Full Text Available Este trabajo de revisión teórico-metodológico surge en el marco del proyecto Doctoral, referido a la incidencia de los medios de comunicación en el ejercicio de la ciudadanía, durante la crisis del 2002 en Uruguay. Esta crisis socioeconómica constituyó una oportunidad, para abordar nuevos campos de visibilidad sobre los procesos colectivos desde las voces bajas de la historia (Guha, 2002 en la región de mayor inequidad del mundo. Producir conocimiento desde la legalidad que otorga la academia sin priorizar el sentido político de nuestras prácticas, nos hace correr el riesgo de caer en un cientificismo funcional a las múltiples formas de dominación que padece nuestra Indoafroiberoamérica, como la denominara el literato mexicano Carlos Fuentes. Se propone analizar cómo en lo público de los espacios públicos radica el potencial para la construcción de nos-otros. La intención es ahondar en los intersticios institucionales de esta modernidad posindustrial para contribuir con una psicología de lo comunitario en movimiento. La Psicología Social Comunitaria trabaja para la transformación social, pero la lucha por la inequidad está en la propia lucha epistémica; lo primero es nuestra propia descolonización. El objetivo es contribuir con epistemologías de las resistencias para construir una opción emancipatoria. Construirnos desde el Sur implica generar una nueva perspectiva que valore la heterogeneidad cultural, un Pachakutik donde el norte sea el sur, como pintó el uruguayo Torres García.

  17. Las experiencias extracorpóreas y las experiencias alucinatorias: relación con variables cognitivas y perceptuales

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    Alejandro Parra

    2008-12-01

    Full Text Available RESUMENLa experiencia fuera del cuerpo (EFC se define como un experiencia mediante la cual el “yo” o centro de conciencia parece ocupar una posición remota respecto a su propio cuerpo. Un total de 648 estudiantes de psicología que incluyó 78% de mujeres y 24% de hombres, completaron un número de escalas para comparar los puntajes de ambos grupos (con EFC N = 132 vs sin EFC N = 516. Los resultados mostraron mayor esquizotipia cognitivo-perceptual, absorción, disociación, propensidad a la fantasía, tendencia a alucinar, imaginería visual en individuos que tienen EFC en comparación con un grupo control. La incidencia de tales experiencias incluye a individuos que han señalado los efectos benéficos de lasEFCs como un modo adaptativo al estrés postraumático.ABSTRACTAbstract. An out-of-body experience or OBE is one in which the “self” or center of awareness seems to the experient to occupy temporarily a position that is spatially remote from his or her body. A total of 648 undergraduate students population included 76% females and 24% males, and who completed a number of scales. Data for experients of OBE were compared with data for those who did not (experients N= 132 vs. non‑experients N= 516. The results showed a higher level of cognitive-perceptual schizotypy, absorption, dissociation, fantasy and hallucination proneness, and visual imagery in OBErs than in non-OBErs. This study suggest that the dissociational model of OBE. Anomalous perceptual experiences and some subjects report beneficial effects from OBEs in an adaptive way.

  18. Ganando fuerza para el ejercicio de nuestra ciudadanía: Guía dirigida a mujeres y personas trans que realizan trabajo sexual

    OpenAIRE

    Vargas Valente, María Elizabeth

    2009-01-01

    A partir de 2005 el UNFPA ha asumido la responsabilidad de apoyar los esfuerzos de prevención y acceso a servicios de salud de las poblaciones más vulnerables frente a la epidemia del VIH, particularmente las trabajadoras sexuales, especialmente en países como el Perú donde la epidemia está concentrada en algunos subgrupos de la población. Es por ello que hoy nos complace presentar la Guía de Capacitación Ganando Fuerza para el Ejercicio de Nuestra Ciudadanía, dirigida a mujeres y personas tr...

  19. EXPERIENCIAS PEDAGÓGICAS CON EL PÁRRAFO

    Directory of Open Access Journals (Sweden)

    Ligni Molano Barona

    2010-01-01

    Full Text Available En este documento se compendia la experiencia que tres profesoras de lengua materna han construido a lo largo de su actividad docente, en lo relacionado con el párrafo. Está estructurado en tres puntos. En el primero, ¿Qué es un párrafo?, se abordan elementos de orden teórico, que, a modo de referentes, sustentan la búsqueda de un concepto propio y eficaz a la hora de emprender la escritura con los estudiantes. Con este fin, se realizó un pequeño estado del arte sobre el estudio del párrafo, en el que se escogieron cinco autores, cuya experiencia en la didáctica textual es bastante amplia, y se indagaron a los pares de la Universidad Icesi. En el segundo, ¿Para qué sirve un párrafo?, se reflexiona acerca de la utilidad y la importancia del párrafo en la escritura de cualquier tipo de texto. En el tercero, ¿Cómo se puede enseñar a escribirlo?, se plantea una metodología para el trabajo del párrafo en el aula.

  20. Algunas experiencias de innovación educativa

    Directory of Open Access Journals (Sweden)

    de Haro, J. José

    2009-09-01

    Full Text Available In this article we show some experiences in educational innovation area performed by teachers with students of ESO and Bachelor at Amor de Dios school in Barcelona (www.amordedios. org. We also discuss the characteristics of blogs, wikis and social networks, as well as their potential usage, all based on the experience carried out with the students. We also present some useful guidelines about selection of the various systems depending on teachers’ needs.Se presentan algunas de las experiencias llevadas a cabo en el ámbito de la innovación educativa con alumnos de ESO y Bachillerato en el centro concertado de educación primaria y secundaria Amor de Dios de Barcelona (www.amordedios.org. Se discuten las características de blogs, wikis y redes sociales, así como sus posibilidades de uso, todo ello en base a las experiencias realizadas con los alumnos. Igualmente se presentan algunas directrices que pueden ayudar para la selección de unos sistemas u otros según las necesidades educativas del profesor.

  1. Rentabilidad de hoteles boutique explicada desde la experiencia memorable

    Directory of Open Access Journals (Sweden)

    Driselda Patricia Sánchez Aguirre

    2017-01-01

    Full Text Available Los hoteles boutique representan una tendencia en el sector de alojamiento, son organizaciones de lujo, con pocas habitaciones, que surgen a partir de las preferencias de viajeros irónicos y exigentes, aquellos que buscan un espacio en el que converja el escape de la realidad, pero al mismo tiempo puedan sentirse en casa. Aunque varios hoteles boutique son empresas pequeñas e incluso familiares, los indicadores reportados del segmento en México muestran organizaciones rentables en términos de la industria. El principal objetivo de este artículo es explicar la rentabilidad de estas organizaciones desde una perspectiva teórica, considerando la teoría de economía de la experiencia y su complementariedad con la teoría de recursos y capacidades. La reflexión final hace alusión al servicio superior, la capacidad para sorprender a sus huéspedes y la creatividad de los recursos humanos como los principales factores en la generación de experiencias memorables y que gracias a la reputación que construyen, contribuyen a la rentabilidad de estas organizaciones. |

  2. The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function.

    Science.gov (United States)

    Al-Tahami, Belqes Abdullah Mohammad; Ismail, Ab Aziz Al-Safi; Bee, Yvonne Tee Get; Awang, Siti Azima; Salha Wan Abdul Rani, Wan Rimei; Sanip, Zulkefli; Rasool, Aida Hanum Ghulam

    2015-01-01

    Obesity is associated with impaired microvascular endothelial function. We aimed to determine the effects of orlistat and sibutramine treatment on microvascular endothelial function, anthropometric and lipid profile, blood pressure (BP), and heart rate (HR). 76 subjects were recruited and randomized to receive orlistat 120 mg three times daily or sibutramine 10 mg daily for 9 months. Baseline weight, BMI, BP, HR and lipid profile were taken. Microvascular endothelial function was assessed using laser Doppler fluximetry and iontophoresis process. Maximum change (max), percent change (% change) and peak flux (peak) in perfusion to acetylcholine (ACh) and sodium nitroprusside (SNP) iontophoresis were used to quantify endothelium dependent and independent vasodilatations. 24 subjects in both groups completed the trial. After treatment, weight and BMI were decreased for both groups. AChmax, ACh % change and ACh peak were increased in orlistat-treated group but no difference was observed for sibutramine-treated group. BP and total cholesterol (TC) were reduced for orlistat-treated group. HR was reduced for orlistat-treated group but was increased in sibutramine-treated group. 9 months treatment with orlistat significantly improved microvascular endothelial function. This was associated with reductions in weight, BMI, BP, HR, TC and low density lipoprotein cholesterol. No effect was seen in microvascular endothelial function with sibutramine.

  3. Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.

    Science.gov (United States)

    Deep, Nicholas L; Graffeo, Christopher S; Copeland, William R; Link, Michael J; Atkinson, John L; Neff, Brian A; Raghunathan, Aditya; Carlson, Matthew L

    2017-03-01

    To report two patients with a history of microvascular decompression (MVD) for hemifacial spasm who presented with Teflon granulomas (TG) mimicking cerebellopontine angle (CPA) tumors and to perform a systematic review of the English-language literature. Case series at a single tertiary academic referral center and systematic review. Retrospective chart review with analysis of clinical, radiological, and histopathological findings. Systematic review using PubMed, Embase, MEDLINE, and Web of Science databases. Two patients with large skull base TGs mimicking CPA tumors clinically and radiographically were managed at the authors' institution. The first presented 4 years after MVD with asymmetrical sensorineural hearing loss, multiple progressive cranial neuropathies, and brainstem edema due to a growing TG. Reoperation with resection of the granuloma confirmed a foreign-body reaction consisting of multinucleated giant cells containing intracytoplasmic Teflon particles. The second patient presented 11 years after MVD with asymmetrical sensorineural hearing loss and recurrent hemifacial spasm. No growth was noted over 2 years, and the patient has been managed expectantly. Only one prior case of TG after MVD for hemifacial spasm has been reported in the English literature. TG is a rare complication of MVD for hemifacial spasm. The diagnosis should be suspected in patients presenting with a new-onset enhancing mass of the CPA after MVD, even when performed decades earlier. A thorough clinical and surgical history is critical toward establishing an accurate diagnosis to guide management and prevent unnecessary morbidity. Surgical intervention is not required unless progressive neurologic complications ensue. 4 Laryngoscope, 127:715-719, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  4. Evaluation of Microvascular Perfusion and Resuscitation after Severe Injury.

    Science.gov (United States)

    Lee, Yann-Leei L; Simmons, Jon D; Gillespie, Mark N; Alvarez, Diego F; Gonzalez, Richard P; Brevard, Sidney B; Frotan, Mohammad A; Schneider, Andrew M; Richards, William O

    2015-12-01

    Achieving adequate perfusion is a key goal of treatment in severe trauma; however, tissue perfusion has classically been measured by indirect means. Direct visualization of capillary flow has been applied in sepsis, but application of this technology to the trauma population has been limited. The purpose of this investigation was to compare the efficacy of standard indirect measures of perfusion to direct imaging of the sublingual microcirculatory flow during trauma resuscitation. Patients with injury severity scores >15 were serially examined using a handheld sidestream dark-field video microscope. In addition, measurements were also made from healthy volunteers. The De Backer score, a morphometric capillary density score, and total vessel density (TVD) as cumulative vessel area within the image, were calculated using Automated Vascular Analysis (AVA3.0) software. These indices were compared against clinical and laboratory parameters of organ function and systemic metabolic status as well as mortality. Twenty severely injured patients had lower TVD (X = 14.6 ± 0.22 vs 17.66 ± 0.51) and De Backer scores (X = 9.62 ± 0.16 vs 11.55 ± 0.37) compared with healthy controls. These scores best correlated with serum lactate (TVD R(2) = 0.525, De Backer R(2) = 0.576, P trauma patients, and seems to provide real-time assessment of microcirculatory perfusion. This study suggests that in severe trauma, many indirect measurements of perfusion do not correlate with microvascular perfusion. However, visualized perfusion deficiencies do reflect a shift toward anaerobic metabolism.

  5. [Macrovascular and microvascular complications in type 2 diabetes patients].

    Science.gov (United States)

    Rosolová, H; Petrlová, B; Simon, J; Sifalda, P; Sípová, I; Sefrna, F

    2008-03-01

    The prevalence of chronic vascular complications is higher in patients with type 2 diabetes mellitus (DM2). The objective of our cross-sectional study was to assess the incidence and types of macrovascular (MVC) and microvascular (mvc) complications and to analyse their relation to the different risk factors and biomarkers in order to improve their prevention. 415 patients (219 men and 196 women) with an average age of 66 +/- 9 years enrolled in the study. A total of 95% of patients with DM2 had a history of hypertension, 27% had MVC (of which 55% had ischaemic heart disease), and 54% had mvc (ofwhich 95% had diabetic nephropathy). The patients with vascular complications were significantly older and had a longer history of DM2; they did not differ for their systolic blood pressure, but had a higher pulse pressure and took more antihypertensives. They did not differ for their lipid levels or the respective therapy. Diabetic patients with MVC and mvc had higher insulin resistance, higher plasmatic levels of total homocysteine and a higher incidence ofalbuminuria or proteinuria. The factors which significantly and independently associated with MVC were male gender, age over 60 years, higher hs-C-reactive protein (hs-CRP) exceeding 1 mg/l, glycaemia over 5.6 mmol/l, lower diastolic blood pressure and lower HDL-cholesterol; mvc associated with higher age over 60 years, a history of DM2 exceeding 8 years, and hs-CRP above 1 mg/l. Our results show that patients with DM2 have a high incidence ofvascular complications significantly associated with age, DM2 history and higher hs-CRP, irrespective of the other monitored parametres.

  6. Upcyte® Microvascular Endothelial Cells Repopulate Decellularized Scaffold

    Science.gov (United States)

    Dally, Iris; Hartmann, Nadja; Münst, Bernhard; Braspenning, Joris; Walles, Heike

    2013-01-01

    A general problem in tissue engineering is the poor and insufficient blood supply to guarantee tissue cell survival as well as physiological tissue function. To address this limitation, we have developed an in vitro vascularization model in which a decellularized porcine small bowl segment, representing a capillary network within a collagen matrix (biological vascularized scaffold [BioVaSc]), is reseeded with microvascular endothelial cells (mvECs). However, since the supply of mvECs is limited, in general, and as these cells rapidly dedifferentiate, we have applied a novel technology, which allows the generation of large batches of quasi-primary cells with the ability to proliferate, whilst maintaining their differentiated functionality. These so called upcyte mvECs grew for an additional 15 population doublings (PDs) compared to primary cells. Upcyte mvECs retained endothelial characteristics, such as von Willebrandt Factor (vWF), CD31 and endothelial nitric oxide synthase (eNOS) expression, as well as positive Ulex europaeus agglutinin I staining. Upcyte mvECs also retained biological functionality such as tube formation, cell migration, and low density lipoprotein (LDL) uptake, which were still evident after PD27. Initial experiments using MTT and Live/Dead staining indicate that upcyte mvECs repopulate the BioVaSc Scaffold. As with conventional cultures, these cells also express key endothelial molecules (vWF, CD31, and eNOS) in a custom-made bioreactor system even after a prolonged period of 14 days. The combination of upcyte mvECs and the BioVaSc represents a novel and promising approach toward vascularizing bioreactor models which can better reflect organs, such as the liver. PMID:22799502

  7. Persistent hemifacial spasm after microvascular decompression: a risk assessment model.

    Science.gov (United States)

    Shah, Aalap; Horowitz, Michael

    2017-06-01

    Microvascular decompression (MVD) for hemifacial spasm (HFS) provides resolution of disabling symptoms such as eyelid twitching and muscle contractions of the entire hemiface. The primary aim of this study was to evaluate the predictive value of patient demographics and spasm characteristics on long-term outcomes, with or without intraoperative lateral spread response (LSR) as an additional variable in a risk assessment model. A retrospective study was undertaken to evaluate the associations of pre-operative patient characteristics, as well as intraoperative LSR and need for a staged procedure on the presence of persistent or recurrent HFS at the time of hospital discharge and at follow-up. A risk assessment model was constructed with the inclusion of six clinically or statistically significant variables from the univariate analyses. A receiving operator characteristic curve was generated, and area under the curve was calculated to determine the strength of the predictive model. A risk assessment model was first created consisting of significant pre-operative variables (Model 1) (age >50, female gender, history of botulinum toxin use, platysma muscle involvement). This model demonstrated borderline predictive value for persistent spasm at discharge (AUC .60; p=.045) and fair predictive value at follow-up (AUC .75; p=.001). Intraoperative variables (e.g. LSR persistence) demonstrated little additive value (Model 2) (AUC .67). Patients with a higher risk score (three or greater) demonstrated greater odds of persistent HFS at the time of discharge (OR 1.5 [95%CI 1.16-1.97]; p=.035), as well as greater odds of persistent or recurrent spasm at the time of follow-up (OR 3.0 [95%CI 1.52-5.95]; p=.002) Conclusions: A risk assessment model consisting of pre-operative clinical characteristics is useful in prognosticating HFS persistence at follow-up.

  8. Obesity is associated with lower coronary microvascular density.

    Directory of Open Access Journals (Sweden)

    Duncan J Campbell

    Full Text Available BACKGROUND: Obesity is associated with diastolic dysfunction, lower maximal myocardial blood flow, impaired myocardial metabolism and increased risk of heart failure. We examined the association between obesity, left ventricular filling pressure and myocardial structure. METHODS: We performed histological analysis of non-ischemic myocardium from 57 patients (46 men and 11 women undergoing coronary artery bypass graft surgery who did not have previous cardiac surgery, myocardial infarction, heart failure, atrial fibrillation or loop diuretic therapy. RESULTS: Non-obese (body mass index, BMI, ≤ 30 kg/m(2, n=33 and obese patients (BMI >30 kg/m(2, n=24 did not differ with respect to myocardial total, interstitial or perivascular fibrosis, arteriolar dimensions, or cardiomyocyte width. Obese patients had lower capillary length density (1145 ± 239, mean ± SD, vs. 1371 ± 333 mm/mm(3, P=0.007 and higher diffusion radius (16.9 ± 1.5 vs. 15.6 ± 2.0 μm, P=0.012, in comparison with non-obese patients. However, the diffusion radius/cardiomyocyte width ratio of obese patients (0.73 ± 0.11 μm/μm was not significantly different from that of non-obese patients (0.71 ± 0.11 μm/μm, suggesting that differences in cardiomyocyte width explained in part the differences in capillary length density and diffusion radius between non-obese and obese patients. Increased BMI was associated with increased pulmonary capillary wedge pressure (PCWP, P<0.0001, and lower capillary length density was associated with both increased BMI (P=0.043 and increased PCWP (P=0.016. CONCLUSIONS: Obesity and its accompanying increase in left ventricular filling pressure were associated with lower coronary microvascular density, which may contribute to the lower maximal myocardial blood flow, impaired myocardial metabolism, diastolic dysfunction and higher risk of heart failure in obese individuals.

  9. Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema

    DEFF Research Database (Denmark)

    Jensen, Mads Radmer; Simonsen, Lene; Karlsmark, Tonny

    2013-01-01

    -enhanced ultrasound; venous occlusion strain-gauge plethysmography; lower-body negative pressure; noninvasive blood pressure measurements; and skin (99m)Tc-pertechnetate clearance technique. Measurements were performed bilaterally and simultaneously in the forearms, enabling use of the nonedematous forearm...... relative microvascular volume, forearm blood flow, skin blood flow, or central or local sympathetic vascular reflexes. Forearm microvascular filtration is increased in patients with BCRL, and more so in the edematous arm. The vascular sympathetic control mechanisms seem to be preserved. We propose...... with unilateral BCRL, the following aspects of upper extremity peripheral circulation were examined: muscle relative microvascular volume; capillary filtration coefficient; central and local sympathetic vascular reflexes; skin blood flow; and forearm blood flow. These were studied via real-time, contrast...

  10. Significance of determination of bone mineral density and osteocalcin in diabetic patients with diabetic microvascular complications

    International Nuclear Information System (INIS)

    Kong Xianghui; Mu Junqing; Lu Kuan

    2003-01-01

    Objective: To study the influence of diabetic microvascular complications on bone mineral density (BMI) and osteocalcin (BGP). Methods: 60 patients with type 2 diabetes mellitus were studied, including 33 with microvascular complications (retinopathy, nephropathy, neuropathy) (group 1) and 27 without complications (group 2). Fasting blood glucose, serum fructosamine (GSP), total alkaline phosphatase (TALP), calcium (Ca 2+ ) levels were measured by biochemical method; osteocalcin (BGP) level was detected by RIA. BMD of the lumbar spine and femur was measured by dual energy X-ray absorptiometry in all patients. Body mass index (BMI) was calculated from the height and body weight. Results: The BMI, GSP, FBG, TALP and Ca 2+ values in the two groups were not much different, but BGP and BMD in group 1 were significantly lower than those in group 2. Conclusion: Bone mineral density (BMD) and BGP values were closely related to the microvascular complications in diabetes, which could decrease bone formation and increase the frequency of osteoporosis

  11. Experiencias exitosas de liderazgo en enfermería

    Directory of Open Access Journals (Sweden)

    Mery Luz Valderrama Sanabria

    2014-11-01

    Full Text Available Introducción: El objetivo de la investigación fue describir la experiencia de profesionales de enfermería en cargos administrativos en salud para fomentar el liderazgo en el futuro profesional de enfermería. Materiales y Métodos: Investigación cualitativa tipo descriptivo, con diseño narrativo de tópicos puesto que se enfoca en una temática que hace referencia al liderazgo en enfermería. Resultados: Se obtuvieron tres categorías: Experiencias exitosas, de la cual surgieron dos subcategorías: óptimo uso de los recursos y cuidado desde cargos directivos. Las otras categorías se denominaron; liderazgo en enfermería y   profesional del futuro. Discusión: Los resultados fueron analizados a la luz de la literatura encontrando semejanzas en cuanto a que el mercado laboral solicita del enfermero la aplicación del liderazgo y se debe redimensionar la formación del futuro profesional y nuevos escenarios de práctica para que responda a las necesidades de un país. Conclusiones: Las dificultades se presentan para ejercer liderazgo al inicio de la vida laboral son el temor, desconocimiento de los derechos como empleado y no saber cuánto vale el trabajo de enfermería. Posteriormente se van presentando por malos entendidos, relaciones interpersonales poco adecuadas, ausencia de colegaje y falta de posicionamiento y reconocimiento de la profesión. Ser líder es un proceso casi inherente a enfermería ya sea desde el ámbito clínico, comunitario o a través del ejercicio de cargos administrativos y se debe fomentar y potenciar en el estudiante.Palabras clave: Liderazgo, Enfermeros, Educación Continua, Satisfacción en el Trabajo. (Fuente: DeCS BIREME.Cómo citar este artículo: Valderrama ML. Experiencias exitosas de liderazgo en enfermería. Rev Cuid. 2014; 5(2: 765-73. http://dx.doi.org/10.15649/cuidarte.v5i2.89

  12. El portafolios como herramienta de análisis en experiencias deformación on-line y presenciales

    Directory of Open Access Journals (Sweden)

    María Xesús AGRA PARDIÑAS

    2009-11-01

    Full Text Available RESUMEN: El trabajo que presentamos ofrece algunas consideraciones acerca del uso que hacemos del portafolios en nuestro trabajo como docentes en experiencias de formación on-line y presencial. En los dos casos, los motivos que nos llevaron a tomar la decisión de utilizarlo son coincidentes con nuestra comprensión de la actividad docente como una continua exploración del apoyo que podemos facilitar a otros y a nosotras mismas, persiguiendo nuestra propia autovaloración y la autoestima de cada persona comprometida. Analizamos el sentido del portafolios, los diferentes enfoques desde los que es posible abordarlo, y las diferencias que pueden atribuirse al soporte en el que se desarrolla (on-line o presencial. Asimismo, las posibilidades que ofrece para el desarrollo de propuestas de enseñanza y aprendizaje centradas en los procesos constructivos de los alumnos. Apuntamos también a las cuestiones sobre las que continuar profundizando.ABSTRACT: This paper offers some considerations about the use we make of the portfolio in our teaching experiences when we give on-line and presential training. In both forms of training, the reasons behind that induced us to use portfolios coincide with our understanding of the teaching experience as a continuous exploration of the support we give to the others and to ourselves aiming at our own valuation and each of the people envolved self-esteem. It is examined the sense teaching gets, the different focus from where it is posible to deal with it and the differences due to its presential/on-line support. In adition to it, the posibilities that offers to the development of teaching and learning proposals base don the sutdents constructive processes. Targeting also to questions about which we should continue deepening.RÉSUMÉ: Le travail que nous présentons offre quelques considérations au sujet de l'emploi qu'on fait du portefeuille dans notre tâche en tant qu'enseignants dans des expériences de formation

  13. Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

    NARCIS (Netherlands)

    Calcagno, Claudia; Lobatto, Mark E.; Dyvorne, Hadrien; Robson, Philip M.; Millon, Antoine; Senders, Max L.; Lairez, Olivier; Ramachandran, Sarayu; Coolen, Bram F.; Black, Alexandra; Mulder, Willem J. M.; Fayad, Zahi A.

    2015-01-01

    Atherosclerotic plaques that cause stroke and myocardial infarction are characterized by increased microvascular permeability and inflammation. Dynamic contrast-enhanced MRI (DCE-MRI) has been proposed as a method to quantify vessel wall microvascular permeability in vivo. Until now, most DCE-MRI

  14. Microvascular endothelial function and cognitive performance: The ELSA-Brasil cohort study.

    Science.gov (United States)

    Brant, Luisa; Bos, Daniel; Araujo, Larissa Fortunato; Ikram, M Arfan; Ribeiro, Antonio Lp; Barreto, Sandhi M

    2018-06-01

    Impaired microvascular endothelial function may be implicated in the etiology of cognitive decline. Yet, current data on this association are inconsistent. Our objective is to investigate the relation of microvascular endothelial function to cognitive performance in the ELSA-Brasil cohort study. A total of 1521 participants from ELSA-Brasil free of dementia underwent peripheral arterial tonometry (PAT) to quantify microvascular endothelial function (PAT-ratio and mean baseline pulse amplitude (BPA)) and cognitive tests that covered the domains of memory, verbal fluency, and executive function at baseline. Cognitive tests in participants aged 55 years old and above were repeated during the second examination (mean follow-up: 3.5 (0.3) years). Linear regression and generalized linear models were used to evaluate the association between endothelial function, global cognitive performance, and performance on specific cognitive domains. In unadjusted cross-sectional analyses, we found that BPA and PAT-ratio were associated with worse global cognitive performance (mean difference for BPA: -0.07, 95% CI: -0.11; -0.03, p<0.01; mean difference for PAT-ratio: 0.11, 95% CI: 0.01; 0.20, p=0.02), worse performance on learning, recall, and word recognition tests (BPA: -0.87, 95% CI: -1.21; -0.52, p<0.01; PAT-ratio: 1.58, 95% CI: 0.80; 2.36, p<0.01), and only BPA was associated with worse performance in verbal fluency tests (-0.70, 95% CI: -1.19; -0.21, p<0.01). Adjustments for age, sex, and level of education rendered the associations statistically non-significant. Longitudinally, there was no association between microvascular endothelial and cognitive functions. The associations between microvascular endothelial function and cognition are explained by age, sex, and educational level. Measures of microvascular endothelial function may be of limited value with regard to preclinical cognitive deficits.

  15. Dual energy spectral CT imaging for the evaluation of small hepatocellular carcinoma microvascular invasion.

    Science.gov (United States)

    Yang, Chuang-Bo; Zhang, Shuang; Jia, Yong-Jun; Yu, Yong; Duan, Hai-Feng; Zhang, Xi-Rong; Ma, Guang-Ming; Ren, Chenglong; Yu, Nan

    2017-10-01

    To study the clinical value of dual-energy spectral CT in the quantitative assessment of microvascular invasion of small hepatocellular carcinoma. This study was approved by our ethics committee. 50 patients with small hepatocellular carcinoma who underwent contrast enhanced spectral CT in arterial phase (AP) and portal venous phase (VP) were enrolled. Tumour CT value and iodine concentration (IC) were measured from spectral CT images. The slope of spectral curve, normalized iodine concentration (NIC, to abdominal aorta) and ratio of IC difference between AP and VP (RIC AP-VP : [RIC AP-VP =(IC AP -IC VP )/IC AP ]) were calculated. Tumours were identified as either with or without microvascular invasion based on pathological results. Measurements were statistically compared using independent samples t test. The receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of tumours microvascular invasion assessment. The 70keV images were used to simulate the results of conventional CT scans for comparison. 56 small hepatocellular carcinomas were detected with 37 lesions (Group A) with microvascular invasion and 19 (Group B) without. There were significant differences in IC, NIC and slope in AP and RIC AP-VP between Group A (2.48±0.70mg/ml, 0.23±0.05, 3.39±1.01 and 0.28±0.16) and Group B (1.65±0.47mg/ml, 0.15±0.05, 2.22±0.64 and 0.03±0.24) (all phepatocellular carcinoma with and without microvascular invasion. Quantitative iodine concentration measurement in spectral CT may be used to provide a new method to improve the evaluation for small hepatocellular carcinoma microvascular invasion. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Inhaled nitric oxide pretreatment but not posttreatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak.

    Science.gov (United States)

    Chetham, P M; Sefton, W D; Bridges, J P; Stevens, T; McMurtry, I F

    1997-04-01

    Ischemia-reperfusion (I/R) pulmonary edema probably reflects a leukocyte-dependent, oxidant-mediated mechanism. Nitric oxide (NO) attenuates leukocyte-endothelial cell interactions and I/R-induced microvascular leak. Cyclic adenosine monophosphate (cAMP) agonists reverse and prevent I/R-induced microvascular leak, but reversal by inhaled NO (INO) has not been tested. In addition, the role of soluble guanylyl cyclase (sGC) activation in the NO protection effect is unknown. Rat lungs perfused with salt solution were grouped as either I/R, I/R with INO (10 or 50 ppm) on reperfusion, or time control. Capillary filtration coefficients (Kfc) were estimated 25 min before ischemia (baseline) and after 30 and 75 min of reperfusion. Perfusate cell counts and lung homogenate myeloperoxidase activity were determined in selected groups. Additional groups were treated with either INO (50 ppm) or isoproterenol (ISO-10 microM) after 30 min of reperfusion. Guanylyl cyclase was inhibited with 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ-15 microM), and Kfc was estimated at baseline and after 30 min of reperfusion. (1) Inhaled NO attenuated I/R-induced increases in Kfc. (2) Cell counts were similar at baseline. After 75 min of reperfusion, lung neutrophil retention (myeloperoxidase activity) and decreased perfusate neutrophil counts were similar in all groups. (3) In contrast to ISO, INO did not reverse microvascular leak. (4) 8-bromoguanosine 3',5'-cyclic monophosphate (8-br-cGMP) prevented I/R-induced microvascular leak in ODQ-treated lungs, but INO was no longer effective. Inhaled NO attenuates I/R-induced pulmonary microvascular leak, which requires sGC activation and may involve a mechanism independent of inhibition of leukocyte-endothelial cell interactions. In addition, INO is ineffective in reversing I/R-induced microvascular leak.

  17. Una experiencia de educacion a distancia: Teología a distancia. La educación integral a distancia en el Instituto Internacional de Teología a Distancia (IITD y en el Instituto Superior de Ciencias Religiosas a Distancia San Agustín (ISCRD Madrid, España

    Directory of Open Access Journals (Sweden)

    José Luis Bravo Sánchez

    2006-06-01

    Full Text Available La singularidad de nuestra institución, viene dada por la naturaleza de su objetivo -la enseñanza de contenidos teológico-pastorales y de Ciencias Religiosas- y por el método educativo que utiliza -el método a distancia-. Su nacimiento, a la par que el surgimiento de la Universidad Nacional de Educación a Distancia en España (UNED, dirigido al ámbito exclusivamente eclesiástico, vino a cubrir una exigencia de la fe y un vacío en la formación del pueblo de Dios, especialmente laicos y religiosas. Con un método histórico-descriptivo, presentamos sistemáticamente en este trabajo, los hitos más destacados en estos más de 30 años dedicados a la educación a distancia. La experiencia acumulada, avalada por estudios, reflexiones, investigaciones, trabajos, reuniones y congresos, ha guiado siempre los pasos de nuestra institución que desde sus inicios ha perseguido una meta: la calidad de la enseñanza como el mejor servicio a nuestros alumnos. Calidad de enseñanza que ocupó buena parte de las preocupacio9nes en la década de los 90, y a la que se dedicó un Congreso especial en el año 1999.

  18. Assessment of macrovascular endothelial function using pulse wave analysis and its association with microvascular reactivity in healthy subjects.

    Science.gov (United States)

    Ibrahim, N N I N; Rasool, A H G

    2017-08-01

    Pulse wave analysis (PWA) and laser Doppler fluximetry (LDF) are non-invasive methods of assessing macrovascular endothelial function and microvascular reactivity respectively. The aim of this study was to assess the correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF. 297 healthy and non-smoking subjects (159 females, mean age (±SD) 23.56 ± 4.54 years) underwent microvascular reactivity assessment using LDF followed by macrovascular endothelial function assessments using PWA. Pearson's correlation showed no correlation between macrovascular endothelial function and microvascular reactivity (r = -0.10, P = 0.12). There was no significant correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF in healthy subjects. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

    DEFF Research Database (Denmark)

    Sjøberg, Kim Anker; Holst, Jens Juul; Rattigan, Stephen

    2014-01-01

    The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery...... in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg...

  20. DISCRIMINACION ETNICA EN RELATOS DE LA EXPERIENCIA ESCOLAR MAPUCHE EN PANGUIPULLI (CHILE)

    OpenAIRE

    Poblete S,María Pía

    2003-01-01

    El propósito de este artículo es indagar en las percepciones y valoraciones de la experiencia escolar en un contexto interétnico. Presentamos información proveniente de 30 relatos sobre la educación y la experiencia escolar de personas mapuches de la precordillera de la Comuna de Panguipulli. Los resultados nos muestran que las experiencias en la escuela estuvieron marcadas por la discriminación étnica en la mayoría de los entrevistados. La discriminación se vivió en la interacción con profes...

  1. Experiencias sorprendentes de química con indicadores de pH caseros

    Directory of Open Access Journals (Sweden)

    Heredia Avalos, S.

    2006-01-01

    Full Text Available En este trabajo se describen varias experiencias sencillas relacionadas con las reacciones ácido-base. Todas ellas pueden realizarse con utensilios de cocina y usando sustancias baratas que pueden encontrarse fácilmente en un supermercado, una farmacia o en casa. En concreto, se describe la forma de obtener algunos indicadores de pH a partir de extractos vegetales o de medicamentos. Además, se proponen varias experiencias en las que se hace uso de estos indicadores con el fin de estudiar las reacciones ácido-base. Todas estas experiencias están enfocadas a alumnos de enseñanza secundaria.

  2. Experiencias de haber crecido con un padre/madre con trastorno mental severo (TMS)

    OpenAIRE

    Vivanco B, Gabriela; Grandón F, Pamela

    2016-01-01

    Introducción. La experiencia de vivir con personas que presentan un Trastorno Mental Severo (TMS) es difícil para las familias, en especial para los hijos quienes han sido poco estudiados. El objetivo de la investigación fue conocer cómo la experiencia de haber vivido con un padre o madre con un trastorno mental severo influyó en la infancia, adolescencia y adultez joven de sus hijos e hijas. Método. Se analizan las experiencias de convivencia con un padre/madre con TMS en 10 hijos (6 hombres...

  3. Tiempo de Respuestas y Experiencia de Usuario Estudio Experimental

    Directory of Open Access Journals (Sweden)

    Delvis Echeverria

    2016-12-01

    Full Text Available La investigación está fundamentada por un estudio experimental, enfocado en la evaluación del comportamiento de los usuarios finales interactuando con tiempos de respuestas en aplicaciones reales. Se tomará como base el aporte de los autores Doherty y Thadani, investigadores de IBM relacionado con los tiempos de respuestas, y las investigaciones de Jacob Nielsen. Se llevarán a cabo un test con usuarios finales, y se expondrán optimizaciones a través de del uso de herramientas que contribuirán a mejorar los tiempos de respuestas de las aplicaciones web. Todo esto engloba una primera instancia de un proyecto que se está llevando a cabo en la empresa GeneXus Consulting, pretendiéndose lograr un punto de encuentro entre el rendimiento de las aplicaciones y la experiencia de usuario.

  4. Apuntes sobre historia empresarial: Relatos de algunas experiencias

    Directory of Open Access Journals (Sweden)

    Elber Berdugo Cotera

    2003-10-01

    Full Text Available El presente articulo tiene como objetivo mostrar la importancia de la Historia Empresarial y la constitución de una línea de investigación para el entendimiento de la historia del país y la comprensión de las principales características de nuestros empresarios tanto en el ámbito regional como en el nacional. Se trata igualmente, de dar cuenta de los aspectos teóricos y metodológicos utilizados en la investigación sobre el estudio de caso de Servientrega y sus gestores, lo mismo que de los principales hallazgos encontrados en ella. Por último, señalar cómo ésta clase de experiencias pueden resultar enriquecedoras para aquellas personas que ejercen una función educativa empresarial o pretenden asumir como proyecto personal y familiar de vida ser empresarios.

  5. Mesas de dinero: generalidades y experiencia en Colombia

    Directory of Open Access Journals (Sweden)

    Johnny Alvarez Jaramillo

    1989-04-01

    Full Text Available RESUMEN   Las necesidades de financiamiento de corto plazo, ha determinado el aguzamiento  de la imaginación para garantizar los recursos. Generalmente, las prácticas financieras en Colombia se extienden sin ningún control institucional; hasta que desafortunadamente, las prácticas desleales  o fraudulentas, llevan al estado a intervenir y reglamentar. Las llamadas MESAS DE DINERO, se han generalizado en nuestro medio en la medida en que proveen recursos financieros de corto plazo, difíciles de conseguir por los canales tradicionales. Los recientes escándalos del sector bursátil y anteriormente, la crisis bancaria, desaceleraron el crecimiento del mercado financiero extrainstitucional, pero no lo han acabado  del todo.El presente artículo, pretende informar brevemente sobre las experiencias de las llamadas  MESAS DE DINERO, su práctica y desarrollo.

  6. Experiencia de Uso de un Laboratorio Remoto de Control

    Directory of Open Access Journals (Sweden)

    Nourdine Aliane

    2010-01-01

    Full Text Available Resumen: En los últimos años, hemos asistido a un desarrollo significativo de los laboratorios remotos. Su integración en el ámbito académico ofrece muchas ventajas desde el punto de vista logístico, pero también conlleva un impacto substancial desde el punto de vistas pedagógico. En este trabajo se presenta una experiencia de utilización de un laboratorio remoto de control, cuyo objetivo es mostrar el alcance de la experimentación remota desde el punto de vista de los alumnos así como desde la perspectiva del profesor. Palabras clave: Laboratorios Remotos, Ingeniería de Control, Educación

  7. La experiencia moral: una ética sin verdades absolutas

    Directory of Open Access Journals (Sweden)

    Barroso Fernández, Óscar

    2016-08-01

    Full Text Available The aim of this paper is to reconstruct the Zubirian approach to the moral kind of knowledge. It is, therefore, necessary to examine Zubiri’s writings on moral anthropology from the 1950s, starting from the most complete one, namely Sentient intelligence. If there is the possibility of contemplating a moral knowledge, we should discover its reference system and determine how it is built upon the contents given in the primordial impression of reality, mediated by the logos and its particular form of knowledge, with all the outlines, experiences and truths. On this basis, we prove that is impossible to found morality in a universal and absolute sense. In any case, the possibility of a universal sphere should not be conceived as something a priori, but rather as a regulative ideal of moral experience, that is, something that reason always tends towards, but never reaches.En este trabajo se pretende reconstruir la propuesta zubiriana de un saber de tipo moral. Este objetivo exige mirar los textos de antropología moral escritos por Zubiri en los años cincuenta desde su obra más acabada: Inteligencia sentiente. Si efectivamente se puede hablar de un saber moral, habrá que descubrir cuál es su sistema de referencia, constituido por determinados contenidos dados en impresión primordial de realidad y mediados por el logos, y su forma de conocimiento, con sus esbozos, experiencias y verdades. A partir de aquí, el autor muestra que no es posible, desde la filosofía de Zubiri, proponer una fundamentación de la moral en sentido universal y absoluto. En todo caso, la posibilidad de un ámbito universal de moralidad no puede ser entendida como algo dado a priori, sino más bien como un ideal regulativo de la experiencia moral, algo a lo que la razón apunta pero nunca llega.

  8. Concomitant macro and microvascular complications in diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Alwakeel Jamal

    2009-01-01

    Full Text Available To determine the prevalence of concomitant microvascular and macrovascular complica-tions of diabetic nephropathy we retrospectively reviewed the medical records of all 1,952 type 2 dia-betic patients followed-up at Security Forces Hospital, Riyadh, Saudi Arabia from January 1989 to December 2004. There were 626 (32.1% patients (294 (47% were males who developed diabetic nephropathy. Their mean age was 66.9 ± 11.4 years, mean duration of diabetes was 15.4 ± 7.5 years, mean age at the onset of nephropathy was 61.5 ± 12.4 years, and mean duration of nephropathy was 3.9 ± 3.8 years. Concomitant diabetic complications included cataract (38.2%, acute coronary syndrome (36.1%, peripheral neuropathy (24.9%, myocardial infarction (24.1%, background retinopathy (22.4%, stroke (17.6%, proliferative retinopathy (11.7%, foot infection (7.3%, limb amputation (3.7% and blindness (3%. Hypertension was documented in 577 (92.2% patients, dyslipidemia in 266 (42.5% and mortality from all causes in 86 (13.7%. There were 148 (23.6% patients with one complication, 81 (12.9% with two, 83 (13.3% with three, and 61 (9.7% with four or more. Dete-rioration of glomerular filtration rate was observed in 464 (74% patients and doubling of serum creatinine in 250 (39.9%, while 95 (15.2% developed end-stage renal disease (ESRD at the end of study and 79 (12.6% required dialysis. Complications were significantly more prevalent among males with greater number reaching ESRD level than females (P< 0.05. Relative risks of developing com-plications were significant after the onset of nephropathy; ACS (1.41, MI (1.49, stroke (1.48, diabetic foot (1.6, amputation (1.58 and death (1.93. We conclude that complications of diabetes are aggre-ssive and progressive including high prevalence of diabetic nephropathy. Careful monitoring and proper institution of management protocols should be implemented to identify diabetic patients at high risk for complications and mitigate progression

  9. Concomitant macro and microvascular complications in diabetic nephropathy

    International Nuclear Information System (INIS)

    Alwakeel, Jamal S; AlSuwaida, Abdulkareem; Isnani, Arthur C; AlHarbi, Ali; Alam Awatif

    2009-01-01

    To determine the prevalence of concomitant microvascular and macro vascular complications of diabetic nephropathy we retrospectively reviewed the medical records of all 1,952 type 2 dia-betic patients followed-up at Security Forces Hospital, Riyadh, Saudi Arabia from January 1989 to December 2004. There were 626 (32.1%) patients (294 (47%) were males) who developed diabetic nephropathy. Their mean age was 66.9 + -11.4 years, mean duration of diabetes was 15.4 + -7.5 years, mean age at the onset of nephropathy was 61.5 + - 12.4 years, and mean duration of nephropathy was 3.9 + - 3.8 years. Concomitant diabetic complications included cataract (38.2%), acute coronary syndrome (36.1%), peripheral neuropathy (24.9%), myocardial infarction (24.1%), background retinopathy (22.4%), stroke (17.6%), proliferative retinopathy (11.7%), foot infection (7.3%), limb amputation (3.7%) and blindness (3%). Hypertension was documented in 577 (92.2%) patients, dyslipidemia in 266 (42.5%) and mortality from all causes in 86 (13.7%). There were 148 (23.6%) patients with one complication, 81 (12.9%) with two, 83 (13.3%) with three, and 61 (9.7%) with four or more. Deterioration of glomerular filtration rate was observed in 464 (74%) patients and doubling of serum creatinine in 250 (39.9%), while 95 (15.2%) developed end-stage renal disease (ESRD) at the end of study and 79 (12.6%) required dialysis. Complications were significantly more prevalent among males with greater number reaching ESRD level than females (P< 0.05). Relative risks of developing complications were significant after the onset of nephropathy; ACS (1.41), MI (1.49), stroke (1.48), diabetic foot (1.6), amputation (1.58) and death (1.93). We conclude that complications of diabetes are aggressive and progressive including high prevalence of diabetic nephropathy. Careful monitoring and proper institution of management protocols should be implemented to identify diabetic patients at high risk for complications and mitigate

  10. Concomitant macro and microvascular complications in diabetic nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Alwakeel, Jamal S; AlSuwaida, Abdulkareem [Div. of Nephrology, Dept. of Medicine, King Khalid Univ., Hospital, Riyadh (Saudi Arabia); Isnani, Arthur C [Dept. of Family and Community Medicine, King Khalid Univ. Hospital, Riyadh (Saudi Arabia); AlHarbi, Ali [Coll. of Medicine and Research Center, King Khalid Univ. Hospital, Riyadh (Saudi Arabia); Awatif, Alam [Div. of Nephrology, Dept. of Medicine, Security Forces Hospital, Riyadh (Saudi Arabia)

    2009-07-01

    To determine the prevalence of concomitant microvascular and macro vascular complications of diabetic nephropathy we retrospectively reviewed the medical records of all 1,952 type 2 dia-betic patients followed-up at Security Forces Hospital, Riyadh, Saudi Arabia from January 1989 to December 2004. There were 626 (32.1%) patients (294 (47%) were males) who developed diabetic nephropathy. Their mean age was 66.9 + -11.4 years, mean duration of diabetes was 15.4 + -7.5 years, mean age at the onset of nephropathy was 61.5 + - 12.4 years, and mean duration of nephropathy was 3.9 + - 3.8 years. Concomitant diabetic complications included cataract (38.2%), acute coronary syndrome (36.1%), peripheral neuropathy (24.9%), myocardial infarction (24.1%), background retinopathy (22.4%), stroke (17.6%), proliferative retinopathy (11.7%), foot infection (7.3%), limb amputation (3.7%) and blindness (3%). Hypertension was documented in 577 (92.2%) patients, dyslipidemia in 266 (42.5%) and mortality from all causes in 86 (13.7%). There were 148 (23.6%) patients with one complication, 81 (12.9%) with two, 83 (13.3%) with three, and 61 (9.7%) with four or more. Deterioration of glomerular filtration rate was observed in 464 (74%) patients and doubling of serum creatinine in 250 (39.9%), while 95 (15.2%) developed end-stage renal disease (ESRD) at the end of study and 79 (12.6%) required dialysis. Complications were significantly more prevalent among males with greater number reaching ESRD level than females (P< 0.05). Relative risks of developing complications were significant after the onset of nephropathy; ACS (1.41), MI (1.49), stroke (1.48), diabetic foot (1.6), amputation (1.58) and death (1.93). We conclude that complications of diabetes are aggressive and progressive including high prevalence of diabetic nephropathy. Careful monitoring and proper institution of management protocols should be implemented to identify diabetic patients at high risk for complications and mitigate

  11. Management of colonic volvulus: Experience in 75 patients Manejo del vólvulo de colon: Experiencia en 75 pacientes

    Directory of Open Access Journals (Sweden)

    C. Mulas

    2010-04-01

    Full Text Available Background: the diagnostic and therapeutic management of colonic volvulus remains nowadays controversial. The election of the type of surgery, its timing, or the use of non-operative decompression must be based on the experience of a multidisciplinary team, the clinical condition of the patient, and the type of volvulus. Objectives: the purpose of this study is to review our experience and results in the treatment of patients with colonic volvulus. Material and methods: we performed a retrospective study of patients diagnosed of colonic volvulus between January 1990 and September 2008 in our institution. Results: we included a total of 75 patients with a mean age of 72.7 years and, in most cases, with associated comorbidities and constipation. The most frequently involved segment was sigmoid colon (85.3%. A rectal tube insertion was used as the only therapeutic measure in 17 patients (22.4%, colonoscopic decompression in 17 (22.4%, and surgery in 41 patients (55.2%. Intestinal resection with primary anastomosis was the most common surgical option. Postoperative morbidity was 43%, being wound infections the most frequent complication. In the group of non-surgical treatment morbidity was 26.4%, albeit with a higher and early rate of recurrences. Conclusions: treatment of colonic volvulus present important morbidity and mortality rates, and its treatment must be individualized. Resective surgery with primary anastomosis in clinically stable patients is the most appropriate therapeutic option, offering the lower recurrence rates.Introducción: el manejo diagnóstico-terapéutico del vólvulo de colon continúa siendo un tema controvertido en la actualidad. En base a la situación clínica del paciente, a la experiencia de un equipo multidisciplinar, deben elegirse el tipo de cirugía, momento de su realización y el empleo de otras opciones descompresivas. Objetivos: los objetivos del presente trabajo son revisar nuestra experiencia y resultados en

  12. Experiencia sobre el conocimiento del Lenguaje Matemático

    Directory of Open Access Journals (Sweden)

    Juan Fco. Ortega Dato

    2002-01-01

    Full Text Available El lenguaje utilizado en el estudio y didáctica de las matemáticas, comprende una serie de estructuras de presentación y símbolos propios que contribuyen de forma determinante a la perfecta comprensión de la materia. El desconocimiento del Lenguaje Matemático complica la transmisión de conceptos en esta ciencia por lo que, en nuestra opinión, su estudio debe constituir una tarea primordial en los diferentes niveles académicos. Con el fin de determinar el nivel de conocimiento sobre el Lenguaje Matemático, hemos diseñado una Encuesta-Test, que se ha propuesto a los alumnos de primera matrícula en las licenciaturas y diplomaturas de Economía y Empresa en los diferentes campus de la Universidad de Castilla-La Mancha. En el presente trabajo analizamos los resultados obtenidos, y presentamos unas líneas de acción con el propósito de subsanar las deficiencias observadas.

  13. Instrumentos para la evaluación de experiencias Flipped Learning en el aula de primaria

    OpenAIRE

    Núñez Marín, Anunciación

    2015-01-01

    Instrumentos de evaluación de experiencia de trabajo en el aula con la metodología Flipped Classroom. Se incluyen tres instrumentos: registro de observación, cuestionario familias, cuestionario alumnos.

  14. 310. Experiencia inicial con el uso del sistema zipfix de osteosíntesis esternal

    Directory of Open Access Journals (Sweden)

    E. Monguió

    2012-04-01

    Conclusiones: En esta experiencia inicial, no se detectaron problemas de eficacia o seguridad del cierre esternal mediante el sistema ZipFix. Los resultados fueron comparables al cierre convencional con alambres de acero. Es necesario un subsiguiente estudio comparativo.

  15. Control social en el asentamiento colonial Nuestra Señora Santa María de los Remedios del Cabo de la Vela

    Directory of Open Access Journals (Sweden)

    Marcela Bernal Arévalo

    2015-01-01

    Full Text Available El asentamiento colonial para la extracción de perlas Nuestra Señora Santa María de los Remedios del Cabo de la Vela fue fundado durante la primera mitad del siglo XVI. Su estudio se ha enfocado en determinar si se presentaron prácticas segregacionistas en - tre los grupos que estuvieron en contacto en este enclave español. Pese a que la Co - rona española impuso políticas de división espacial y control de los diferentes grupos socioculturales dentro de la colonia, los re - sultados preliminares sugieren que no siem - pre se hicieron efectivas.

  16. Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, Gui-Zhen [Department of Health, Linyi People' s Hospital, Shandong University, Shandong (China); Tian, Wei [Department of Nursing, Linyi Oncosurgical Hospital, Shandong (China); Fu, Hai-Tao [Department of Ophthalmology, Linyi People' s Hospital, Shandong University, Shandong (China); Li, Chao-Peng, E-mail: lcpcn@163.com [Eye Institute of Xuzhou, Jiangsu (China); Liu, Ban, E-mail: liuban@126.com [Department of Cardiology, Shanghai Tenth People' s Hospital, Tongji University School of Medicine, Shanghai (China)

    2016-02-26

    Microvascular dysfunction is an important characteristic of diabetic retinopathy. Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. In this study, we investigated the role of lncRNA-MEG3 in diabetes-related microvascular dysfunction. We show that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress. MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation. MEG3 knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro. The role of MEG3 in endothelial cell function is mainly mediated by the activation of PI3k/Akt signaling. MEG3 up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications. - Highlights: • LncRNA-MEG3 level is down-regulated upon diabetic stress. • MEG3 knockdown aggravates retinal vascular dysfunction in vivo. • MEG3 regulates retinal endothelial cell function in vitro. • MEG3 regulates endothelial cell function through PI3k/Akt signaling.

  17. Pathways for insulin access to the brain: the role of the microvascular endothelial cell.

    Science.gov (United States)

    Meijer, Rick I; Gray, Sarah M; Aylor, Kevin W; Barrett, Eugene J

    2016-11-01

    Insulin affects multiple important central nervous system (CNS) functions including memory and appetite, yet the pathway(s) by which insulin reaches brain interstitial fluid (bISF) has not been clarified. Recent studies demonstrate that to reach bISF, subarachnoid cerebrospinal fluid (CSF) courses through the Virchow-Robin space (VRS) which sheaths penetrating pial vessels down to the capillary level. Whether insulin predominantly enters the VRS and bISF by local transport through the blood-brain barrier, or by being secreted into the CSF by the choroid plexus, is unknown. We injected 125 I-TyrA14-insulin or regular insulin intravenously and compared the rates of insulin reaching subarachnoid CSF with its plasma clearance by brain tissue samples (an index of microvascular endothelial cell binding/uptake/transport). The latter process was more than 40-fold more rapid. We then showed that selective insulin receptor blockade or 4 wk of high-fat feeding each inhibited microvascular brain 125 I-TyrA14-insulin clearance. We further confirmed that 125 I-TyrA14-insulin was internalized by brain microvascular endothelial cells, indicating that the in vivo tissue association reflected cellular transport, not simply microvascular tracer binding. Copyright © 2016 the American Physiological Society.

  18. Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction

    International Nuclear Information System (INIS)

    Qiu, Gui-Zhen; Tian, Wei; Fu, Hai-Tao; Li, Chao-Peng; Liu, Ban

    2016-01-01

    Microvascular dysfunction is an important characteristic of diabetic retinopathy. Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. In this study, we investigated the role of lncRNA-MEG3 in diabetes-related microvascular dysfunction. We show that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress. MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation. MEG3 knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro. The role of MEG3 in endothelial cell function is mainly mediated by the activation of PI3k/Akt signaling. MEG3 up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications. - Highlights: • LncRNA-MEG3 level is down-regulated upon diabetic stress. • MEG3 knockdown aggravates retinal vascular dysfunction in vivo. • MEG3 regulates retinal endothelial cell function in vitro. • MEG3 regulates endothelial cell function through PI3k/Akt signaling.

  19. Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

    Science.gov (United States)

    Zhao, Lina; Fu, Zhuo; Wu, Jing; Aylor, Kevin W.; Barrett, Eugene J.; Cao, Wenhong

    2015-01-01

    Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance and metabolic insulin resistance. We assessed insulin responses in all arterial segments, including aorta, distal saphenous artery and the microvasculature, as well as the metabolic insulin responses in muscle in rats fed on a high-fat diet (HFD) for various durations ranging from 3 days to 4 weeks with or without sodium salicylate treatment. Compared with controls, HFD feeding significantly blunted insulin-mediated Akt (protein kinase B) and eNOS [endothelial nitric oxide (NO) synthase] phosphorylation in aorta in 1 week, blunted vasodilatory response in small resistance vessel in 4 weeks and microvascular recruitment in as early as 3 days. Insulin-stimulated whole body glucose disposal did not begin to progressively decrease until after 1 week. Salicylate treatment fully inhibited vascular inflammation, prevented microvascular insulin resistance and significantly improved muscle metabolic responses to insulin. We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. Our data suggest microvascular insulin resistance contributes to the development of metabolic insulin resistance in muscle and muscle microvasculature is a potential therapeutic target in the prevention and treatment of diabetes and its related complications. PMID:26265791

  20. Hemifacial spasm : Intraoperative electromyographic monitoring as a guide for microvascular decompression

    NARCIS (Netherlands)

    Mooij, JJA; Mustafa, MK; van Weerden, TW

    2001-01-01

    OBJECTIVE: Microvascular decompression is the logical and well-accepted treatment of choice for hemifacial spasm (HFS). In experienced hands, good to excellent results can be obtained. However, sometimes the exact site of the vascular compression is unclear. The aim of this study was to analyze

  1. My First 100 Consecutive Microvascular Free Flaps: Pearls and Lessons Learned in First Year of Practice

    Directory of Open Access Journals (Sweden)

    Edward I. Chang, MD

    2013-07-01

    Conclusions: As a young plastic surgeon embarking in reconstructive plastic surgery at an academic institution, the challenges and dilemmas presented in the first year of practice have been daunting but also represent opportunities for learning and improvement. Skills and knowledge acquired from time, experience, and mentors are invaluable in optimizing outcomes in microvascular free flap reconstruction.

  2. Tumor microvascular changes in antiangiogenic treatment : Assessment by magnetic resonance contrast media of different molecular weights

    NARCIS (Netherlands)

    Turetschek, K; Preda, A; Novikov, [No Value; Brasch, RC; Weinmann, HJ; Wunderbaldinger, P; Roberts, TPL

    Purpose: To test magnetic resonance (MR) contrast media of different molecular weights (MWs) for their potential to characterize noninvasively microvascular changes in an experimental tumor treatment model. Materials and Methods: MD-MBA-435, a poorly differentiated human breast cancer cell line, was

  3. Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels.

    Science.gov (United States)

    Cuchiara, Michael P; Gould, Daniel J; McHale, Melissa K; Dickinson, Mary E; West, Jennifer L

    2012-11-07

    Despite tremendous efforts, tissue engineered constructs are restricted to thin, simple tissues sustained only by diffusion. The most significant barrier in tissue engineering is insufficient vascularization to deliver nutrients and metabolites during development in vitro and to facilitate rapid vascular integration in vivo. Tissue engineered constructs can be greatly improved by developing perfusable microvascular networks in vitro in order to provide transport that mimics native vascular organization and function. Here a microfluidic hydrogel is integrated with a self-assembling pro-vasculogenic co-culture in a strategy to perfuse microvascular networks in vitro. This approach allows for control over microvascular network self-assembly and employs an anastomotic interface for integration of self-assembled micro-vascular networks with fabricated microchannels. As a result, transport within the system shifts from simple diffusion to vessel supported convective transport and extra-vessel diffusion, thus improving overall mass transport properties. This work impacts the development of perfusable prevascularized tissues in vitro and ultimately tissue engineering applications in vivo.

  4. Adipose tissue-derived microvascular fragments from aged donors exhibit an impaired vascularisation capacity

    Directory of Open Access Journals (Sweden)

    MW Laschke

    2014-10-01

    Full Text Available Adipose tissue-derived microvascular fragments are promising vascularisation units for applications in the field of tissue engineering. Elderly patients are the major future target population of such applications due to an increasing human life expectancy. Therefore, we herein investigated the effect of aging on the fragments’ vascularisation capacity. Microvascular fragments were isolated from epididymal fat pads of adult (8 months and aged (16 months C57BL/6 donor mice. These fragments were seeded onto porous polyurethane scaffolds, which were implanted into dorsal skinfold chambers to study their vascularisation using intravital fluorescence microscopy, histology and immunohistochemistry. Scaffolds seeded with fragments from aged donors exhibited a significantly lower functional microvessel density and intravascular blood flow velocity. This was associated with an impaired vessel maturation, as indicated by vessel wall irregularities, constantly elevated diameters and a lower fraction of CD31/α-smooth muscle actin double positive microvessels in the implants’ border and centre zones. Additional in vitro analyses revealed that microvascular fragments from adult and aged donors do not differ in their stem cell content as well as in their release of angiogenic growth factors, survival and proliferative activity under hypoxic conditions. However, fragments from aged donors exhibit a significantly lower number of matrix metalloproteinase -9-positive perivascular cells. Taken together, these findings demonstrate that aging is a crucial determinant for the vascularisation capacity of isolated microvascular fragments.

  5. Improving diagnosis and treatment of women with angina pectoris and microvascular disease

    DEFF Research Database (Denmark)

    Prescott, Eva; Abildstrøm, Steen Zabell; Aziz, Ahmed

    2014-01-01

    BACKGROUND: The iPOWER study aims at determining whether routine assessment of coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease is feasible and identifies women at risk. METHODS: All women with angina referred to invasive angiographic assess...

  6. Uptake of Single-Walled Carbon Nanotubes Conjugated with DNA by Microvascular Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Joseph Harvey

    2012-01-01

    Full Text Available Single-walled carbon nanotubes (SWCNTs have been proposed to have great therapeutic potential. SWCNTs conjugated with drugs or genes travel in the systemic circulation to reach target cells or tissues following extravasation from microvessels although the interaction between SWCNT conjugates and the microvascular endothelial cells (ECs remains unknown. We hypothesized that SWCNT-DNA conjugates would be taken up by microvascular ECs and that this process would be facilitated by SWCNTs compared to facilitation by DNA alone. ECs were treated with various concentrations of SWCNT-DNA-FITC conjugates, and the uptake and intracellular distribution of these conjugates were determined by a confocal microscope imaging system followed by quantitative analysis of fluorescence intensity. The uptake of SWCNT-DNA-FITC conjugates (2 μg/mL by microvascular ECs was significantly greater than that of DNA-FITC (2 μg/mL, observed at 6 hrs after treatment. For the intracellular distribution, SWCNT-DNA-FITC conjugates were detected in the nucleus of ECs, while DNA-FITC was restricted to the cytoplasm. The fluorescence intensity and distribution of SWCNTs were concentration and time independent. The findings demonstrate that SWCNTs facilitate DNA delivery into microvascular ECs, thus suggesting that SWCNTs serving as drug and gene vehicles have therapeutic potential.

  7. Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia

    NARCIS (Netherlands)

    Johannes, Tanja; Mik, Egbert G.; Nohé, Boris; Raat, Nicolaas J. H.; Unertl, Klaus E.; Ince, Can

    2006-01-01

    INTRODUCTION: Septic renal failure is often seen in the intensive care unit but its pathogenesis is only partly understood. This study, performed in a normotensive rat model of endotoxemia, tests the hypotheses that endotoxemia impairs renal microvascular PO2 (microPO2) and oxygen consumption

  8. PATENCY AND HEALING OF MICROVASCULAR PROSTHESES - A REVIEW OF 10 YEARS OF EXPERIMENTAL WORK IN GRONINGEN

    NARCIS (Netherlands)

    VANDERLEI, B; ROBINSON, PH

    1993-01-01

    From 1982 onwards, in Groningen, The Netherlands, we have worked on the experimental evaluation and development of microvascular prostheses in rats and rabbits. In this review article a systematic overview of this experimental work is presented and the results are discussed with regard to the

  9. Effect of Antimicrobial Compounds on Balamuthia mandrillaris Encystment and Human Brain Microvascular Endothelial Cell Cytopathogenicity▿

    OpenAIRE

    Siddiqui, Ruqaiyyah; Matin, Abdul; Warhurst, David; Stins, Monique; Khan, Naveed Ahmed

    2007-01-01

    Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.

  10. Hepatitis B and C seroprevalence in patients with diabetes mellitus and its relationship with microvascular complications

    Directory of Open Access Journals (Sweden)

    Kadir Gisi

    2016-12-01

    Full Text Available Introduction: Diabetic patients are susceptible to bacterial, viral and fungal infections because of various deficiencies in the immune system. Aim: To investigate a possible link between hepatitis B/C prevalence and microvascular complications as well as duration of diabetes. Material and methods: In total 1263 diabetic patients (1149 type 2, 114 type 1 were enrolled in the study. The control group consisted of 1482 healthy blood donors who were over 40 years old. All diabetic patients were tested for HBsAg, anti-HBs and anti-HCV beside routine laboratory tests. Diabetic patients were divided into three groups according to their diabetes duration, and all of the patients were scanned for microvascular complications. Demographic data of all patients were recorded. Results : HBsAg seropositivity was 3.7% in diabetic patients and 1.08% in the control group; this difference was statistically significant (p < 0.001. HBsAg positivity rates in type 1 and type 2 diabetics were 0.8% and 4%, respectively (p = 0.09. HCV seropositivity was 2.2% for diabetics and 0.5% for the control group; this difference was statistically significant (p 0.05. Also, no relationship was found between microvascular complications of diabetes and hepatitis B/C seropositivity. Conclusions : Hepatitis B and C seroprevalence was found to be increased in diabetes mellitus; however, there was no relationship between hepatitis seroprevalence and the duration or microvascular complications of diabetes.

  11. The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction

    NARCIS (Netherlands)

    Buise, Marc P.; Ince, Can; Tilanus, Hugo W.; Klein, Jan; Gommers, Diederik; van Bommel, Jasper

    2005-01-01

    Esophagectomy followed by gastric tube reconstruction is the surgical treatment of choice for patients with esophageal cancer. Complications of the cervical anastomosis are associated with impaired microvascular blood flow (MBF) and ischemia in the gastric fundus. The aim of the present study was to

  12. GLP-1-based therapies have no microvascular effects in type 2 diabetes mellitus

    NARCIS (Netherlands)

    Smits, Mark M.; Tonneijck, Lennart; Muskiet, Marcel H.A.; Hoekstra, Trynke; Kramer, Mark H.H.; Diamant, Michaela; Serné, Erik H.; Van Raalte, Daniël H.

    2016-01-01

    Objective - To assess the effects of glucagon-like peptide (GLP)-1-based therapies (ie, GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) on microvascular function in patients with type 2 diabetes mellitus. Approach and Results - We studied 57 patients with type 2 diabetes mellitus

  13. MICROVASCULAR CHANGES IN AGED RAT FOREBRAIN - EFFECTS OF CHRONIC NIMODIPINE TREATMENT

    NARCIS (Netherlands)

    de Jong, Giena; Weerd, H. de; Schuurman, T.; Traber, J.; Luiten, P.G.M.

    1990-01-01

    In the present study the effects of long-term treatment with the 1,4-dihydropyridine calcium antagonist nimodipine on ultrastructural alterations of the microvascular morphology were examined in the frontoparietal cortex, entorhinal cortex and CA1 of the hippocampus in the aged rat. Qualitative

  14. Preservation of intestinal microvascular Po2 during normovolemic hemodilution in a rat model

    NARCIS (Netherlands)

    van Bommel, J.; Siegemund, M.; Henny, C. P.; van den Heuvel, D. A.; Trouwborst, A.; Ince, C.

    2000-01-01

    The effect of hemodilution on the intestinal microcirculatory oxygenation is not clear. The aim of this study was to determine the effect of moderate normovolemic hemodilution on intestinal microvascular partial oxygen pressure (Po2) and its relation to the mesenteric venous Po2 (Pmvo2).

  15. SENDEROS DE REPOSICIONAMIENTO A LA COMPLEJIDAD PRAXIOLÓGICA DEL TRABAJO SOCIAL: PATRIMONIO DISCIPLINAR EN CLAVE EXPERIENCIA DE FUSIÓN TEORÍA-PRÁCTICA

    Directory of Open Access Journals (Sweden)

    Víctor R. Yáñez Pereira

    2015-01-01

    Full Text Available Este artículo parte del entendido de que la realidad se va formando como una trama que urde cosas con semánticas, configurando a nivel de la conciencia y del lenguaje una densidad discursiva que devela el contenido de verdad situado en la zona de nuestras experiencias. Veremos que el pensamiento debe traducir las lógicas de trabajo social en una expresión de ruptura ante la totalización impositiva de cánones ideologizantes y deterministas, contenidos en el conocimiento heredado desde la tradición viejo europea del siglo XVII, y que en su condición moderna, con extremada violencia, han incrustado y naturalizado poderosas polarizaciones binarias, como ha sido el caso de la segregación entre los núcleos de teoría respecto de los de práctica y viceversa. Por lo mismo, la disciplina debe relevar una comprensión mediada por el cuestionamiento de una realidad que, también, le interroga, en cuanto movimiento socio-histórico. Ello se erige en la contradicción contingente y dinamizante de las contemporáneas relaciones sociales y su conflictiva manifestación; «imágenes que piensan », como el producto de unas semánticas que entrelazan el potencial enunciativo con el acto proposicional de los trabajadores y las trabajadoras sociales sobre fenómenos en realización, trayendo como resultado la capacidad de nombrar aquello que da sentido a reales oportunidades de cambio o transformación en diversos contextos y espacios sociales.

  16. Adquisición de competencias transversales en alumnos de pregrado de Ciencias de la Salud en la Universidad Complutense: una experiencia positiva

    Directory of Open Access Journals (Sweden)

    L.A. Arráez-Aybar

    Full Text Available Introducción. Presentamos los resultados de la evaluación de las Jornadas Complutenses de Investigación para alumnos de pregrado en Ciencias de la Salud, una actividad académica con dos años de experiencia y una participación de 1.434 alumnos, creada en nuestra universidad para impulsar en los alumnos de pregrado habilidades comunicativas y de metodología en investigación. Sujetos y métodos. Mediante una encuesta anónima se evaluó en los alumnos el grado de satisfacción e interés (aprender metodología científica, aprender a hablar en público, etc. y también en los moderadores de mesas (originalidad, planteamiento metodológico, presentación iconográfica, exposición oral, viabilidad y relevancia de las comunicaciones presentadas. Resultados. En las I Jornadas se inscribieron 500 alumnos, todos de la Universidad Complutense de Madrid (UCM, y se presentaron un total de 169 comunicaciones (129 orales, 40 pósters. En las II Jornadas lo hicieron 934 alumnos, 838 de la UCM y 96 de otras nueve universidades, y se presentaron un total de 286 comunicaciones (180 orales, 106 pósteres. Conclusiones. Es una actividad en la que el alumno pasa a ser un gestor activo y difusor de aprendizaje, y potencia de una manera dinámica habilidades en comunicación científica. También tiene beneficios para el profesorado y la institución universitaria, que la convierten en una ‘terapia pedagógica holística'.

  17. JOSÉ MARTÍ - život a dílo se zaměřením na jeho eseje Madre América a Nuestra América

    OpenAIRE

    Bočková, Sandra

    2015-01-01

    In my Bachelor thesis entitled "JOSÉ MARTÍ - life and work with orientation to his essays Madre América and Nuestra América" I am going to pursue two of his principal essays titled Madre América and Nuestra América which contain Marti's ideas related to the self- determination of the nations of Latin America. In order to analyse the respective themes, I consider necessary to introduce the author first. In my opinion, José Martí is one of the most important figures in the Cuban colonial era; h...

  18. Dysregulation of coronary microvascular reactivity in asymptomatic patients with type 2 diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Momose, Mitsuru; Neverve, Jodi; Nekolla, Stephan G.; Schwaiger, Markus; Bengel, Frank M. [Nuklearmedizinische Klinik und Poliklinik der Technischen Universitaet Muenchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich (Germany); Abletshauser, Claudia [Department of Medicine, Novartis Pharma GmbH, Nuernberg (Germany); Schnell, Oliver; Standl, Eberhard [Institut fuer Diabetesforschung, Munich (Germany)

    2002-12-01

    In diabetic patients, a number of studies have suggested an impairment of vascular reactivity in response to vasodilatory stimuli. The pattern of dysregulation at the coronary microcirculatory level, however, has not been clearly defined. Thus, it was the aim of this study to characterise coronary microvascular function non-invasively in a homogeneous group of asymptomatic type 2 diabetic patients. In 46 patients with type 2 diabetes, myocardial blood flow (MBF) was quantified at baseline, in response to cold pressor test (CPT) and during adenosine-mediated vasodilation using positron emission tomography and nitrogen-13 ammonia. None of the patients had been treated with insulin, and none had symptoms of cardiac disease. Decreased MBF during CPT, indicating microvascular dysregulation, was observed in 16 patients (CPT-), while 30 patients demonstrated increased MBF during CPT (CPT+). Response to CPT was mildly, but significantly correlated with response to adenosine (r=0.44, P=0.0035). There was no difference in HbA1c, serum lipid levels or serum endothelial markers between the groups. Microvascular dysregulation in the CPT- group was associated with elevated baseline MBF (P<0.0001), reduced baseline vascular resistance (P=0.0026) and an abnormal increase in resistance during CPT (P=0.0002). In conclusion, coronary microvascular dysregulation is present in approximately one-third of asymptomatic, non-insulin-treated type 2 diabetic patients. Elevated baseline blood flow and reduced microvascular resistance at rest are characteristics of this dysregulation. These data suggest a state of activation of endothelial-dependent vasodilation at baseline which appears to limit the flow response to stress conditions. (orig.)

  19. Acute limb heating improves macro- and microvascular dilator function in the leg of aged humans.

    Science.gov (United States)

    Romero, Steven A; Gagnon, Daniel; Adams, Amy N; Cramer, Matthew N; Kouda, Ken; Crandall, Craig G

    2017-01-01

    Local heating of an extremity increases blood flow and vascular shear stress throughout the arterial tree. Local heating acutely improves macrovascular dilator function in the upper limbs of young healthy adults through a shear stress-dependent mechanism but has no such effect in the lower limbs of this age group. The effect of acute limb heating on dilator function within the atherosclerotic prone vasculature of the lower limbs of aged adults is unknown. Therefore, the purpose of this study was to test the hypothesis that acute lower limb heating improves macro- and microvascular dilator function within the leg vasculature of aged adults. Nine young and nine aged adults immersed their lower limbs at a depth of ~33 cm into a heated (~42°C) circulated water bath for 45 min. Before and 30 min after heating, macro (flow-mediated dilation)- and microvascular (reactive hyperemia) dilator functions were assessed in the lower limb, following 5 min of arterial occlusion, via Doppler ultrasound. Compared with preheat, macrovascular dilator function was unchanged following heating in young adults (P = 0.6) but was improved in aged adults (P = 0.04). Similarly, microvascular dilator function, as assessed by peak reactive hyperemia, was unchanged following heating in young adults (P = 0.1) but was improved in aged adults (P lower limb heating improves both macro- and microvascular dilator function in an age dependent manner. We demonstrate that lower limb heating acutely improves macro- and microvascular dilator function within the atherosclerotic prone vasculature of the leg in aged adults. These findings provide evidence for a potential therapeutic use of chronic lower limb heating to improve vascular health in primary aging and various disease conditions. Copyright © 2017 the American Physiological Society.

  20. Design, manufacture and in-vitro evaluation of a new microvascular anastomotic device.

    Science.gov (United States)

    Huang, Shao-Fu; Wang, Tien-Hsiang; Wang, Hsuan-Wen; Huang, Shu-Wei; Lin, Chun-Li; Kuo, Hsien-Nan; Yu, Tsung-Chih

    2013-01-01

    Many microvascular anastomoses have been proposed for use with physical assisted methods, such as cuff, ring-pin, stapler, clip to the anastomose blood vessel. The ring-pin type anastomotic device (e.g., 3M Microvascular Anastomotic System) is the most commonly used worldwide because the anastomotic procedure can be conducted more rapidly and with fewer traumas than using sutures. However, problems including vessel leakage, ring slippage, high cost and high surgical skill demand need to be resolved. The aim of this study is to design and manufacture a new anastomotic device for microvascular anastomosis surgery and validate the device functions with in-vitro testing. The new device includes one pair of pinned rings and a set of semi-automatic flap apparatus designed and made using computer-aided design / computer-aided manufacture program. A pair of pinned rings was used to impale vessel walls and establish fluid communication with rings joined. The semi-automatic flap apparatus was used to assist the surgeon to invert the vessel walls and impale onto each ring pin, then turning the apparatus knob to bring the rings together. The device was revised until it became acceptable for clinical requires. An in-vitro test was performed using a custom-made seepage micro-fluid system to detect the leakage of the anastomotic rings. The variation between input and output flow for microvascular anastomoses was evaluated. The new microvascular anastomotic device was convenient and easy to use. It requires less time than sutures to invert and impale vessel walls onto the pinned rings using the semi-automatic flap apparatus. The in-vitro test data showed that there were no tears from the joined rings seam during the procedures. The new anastomotic devices are effective even with some limitations still remaining. This device can be helpful to simplify the anastomosis procedure and reduce the surgery time.

  1. Microvascular Endothelial Dysfunction in Sedentary, Obese Humans is mediated by NADPH Oxidase; Influence of Exercise Training

    Science.gov (United States)

    La Favor, Justin D.; Dubis, Gabriel S.; Yan, Huimin; White, Joseph D.; Nelson, Margaret A.M.; Anderson, Ethan J.; Hickner, Robert C.

    2016-01-01

    Objective The objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on microvascular endothelial function in obese human subjects and to determine the efficacy of an aerobic exercise intervention on alleviating obesity-associated dysfunctionality. Approach and Results Young, sedentary men and women were divided into lean (BMI 18–25; n=14), intermediate (BMI 28–32.5; n=13), and obese (BMI 33–40; n=15) groups. A novel microdialysis technique was utilized to detect elevated interstitial hydrogen peroxide (H2O2) and superoxide levels in the vastus lateralis of obese compared to both lean and intermediate subjects. Nutritive blood flow was monitored in the vastus lateralis via the microdialysis-ethanol technique. A decrement in acetylcholine-stimulated blood flow revealed impaired microvascular endothelial function in the obese subjects. Perfusion of apocynin, an NADPH oxidase (Nox) inhibitor, lowered (normalized) H2O2 and superoxide levels and reversed microvascular endothelial dysfunction in obese subjects. Following 8-weeks of exercise, H2O2 levels were decreased in the obese subjects and microvascular endothelial function in these subjects was restored to levels similar to lean subjects. Skeletal muscle protein expression of the Nox subunits p22phox, p47phox, and p67phox were increased in obese relative to lean subjects, where p22phox and p67phox expression was attenuated by exercise training in obese subjects. Conclusions This study implicates Nox as a source of excessive ROS production in skeletal muscle of obese individuals, and links excessive Nox derived ROS to microvascular endothelial dysfunction in obesity. Furthermore, aerobic exercise training proved to be an effective strategy for alleviating these maladies. PMID:27765769

  2. Actividades en la adolescencia: Experiencias óptimas y autopercepciones

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    Alejandra Daniela Calero

    2016-12-01

    Full Text Available El objetivo de este trabajo fue comparar los niveles de experiencias óptimas (EO que los adolescentes reportan en distintas actividades del contexto escolar y extraescolar y analizar cómo se relacionan estos niveles con el autoconcepto y autoestima en la población adolescente de la Ciudad Autónoma de Buenos Aires, Argentina (CABA-AR. Para ello se administró el Inventario Breve de EO y el Perfil de Autopercepción a 399 adolescentes concurrentes a escuelas de educación media de la CABA-AR. Se realizó un ANOVA de medidas repetidas con efecto principal intrasujeto para comparar las EO en cada actividad y un análisis de correlación para estudiar la relación entre EO y el autoconcepto y autoestima. Entre los resultados se encontró que los adolescentes experimentan mayores niveles de ocurrencia de EO en las actividades extracurriculares. Con respecto al autoconcepto y autoestima, las relaciones halladas fueron en todos los casos positivas y mostraron diferencias según el tipo de actividad en el cual se reportaban las EO.

  3. Teleodontología: Conceptos, experiencias y proyecciones

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    Ricardo Cartes-Velásquez

    Full Text Available Los avances tecnológicos han influenciado la práctica sanitaria de forma radical, teniendo en las últimas décadas especial importancia las “Tecnologías de la Información y Comunicación”, que facilitaron el surgimiento de una nueva modalidad: “la atención a distancia”, generalmente llamada telemedicina y que en nuestro caso ha tenido un desarrollo más reciente en la teleodontología. Nuestro objetivo es hacer una revisión de los conceptos, historia, campos de aplicación y experiencias documentadas alrededor del mundo, consideraciones legales, así como plantear algunas aplicaciones y proyecciones futuras de la teleodontología. En general encontramos un positivo, aunque escaso, desarrollo de la teleodontología bajo sus diversas modalidades, que ha aumentado en los últimos años, superando cuestionamientos clínicos y legales iniciales. El mejoramiento y aparición de nuevas tecnologías, y una actitud creativa por parte de los dentistas se perfilan como los principales sustratos para la expansión de esta práctica

  4. Releyendo Frankfurt: la Experiencia Estética en Adorno

    Directory of Open Access Journals (Sweden)

    Stra, Sebastián Matías

    2013-01-01

    Full Text Available [es]Intentaremos en este trabajo explorar la noción de Experiencia Estética en la obra de Theodor Adorno, entendiéndola como una compleja mediación conceptual que nos puede permitir dar cuenta de las oscuras configuraciones de la relación entre arte, cultura y conocimiento en la producción del pensador de Frankfurt. En este marco, cruzaremos las reflexiones estéticas adornianas con lecturas más cercanas a nuestro campo disciplinar, como la noción de Industria Cultural y la interpretación del mito y su derivación en la conformación de la racionalidad moderna. [en] In this work, we will try to explore the notion of Aesthetic Experience in Theodor Adorno`s work, understanding it as a complex conceptual mediation that can allow us getting in the dark settings of the relationship between art, culture and knowledge in the production of Frankfurt`s thinker. Like this, we are going to cross adornians aesthetic reflections with readings that are going to be closer to our disciplinary field, as the notion of cultural industry and the interpretation of myth and its derivation in the configuration of modern rationality.

  5. Derechos humanos y movimientos sociales: experiencia participativa en la universidad

    Directory of Open Access Journals (Sweden)

    Pablo Álvarez Domínguez

    2011-01-01

    Full Text Available Este artículo recoge una serie de una serie de reflexiones teóricas y prácticas, relacionadas con la necesidad de aprender en una sociedad globalizada sobre Derechos Humanos. Reto que ha de ir ligado a un compromiso de acción que debe desarrollarse en cualquiera de las esferas sociales (movimientos, asociaciones, ONG's, etc. que tenemos a nuestro alcance. Asumimos que en el contexto del proceso de enseñanza y aprendizaje en el contexto universitario, el tema de los Derechos Humanos es una asignatura pendiente a la que ha de dar respuesta la Universidad como institución al servicio de la sociedad y promotora del desarrollo de la justicia social. La enseñanza y el aprendizaje de estos derechos no consiste sólo en darlos a conocer, sino en asimilarlos, asumirlos e integrarlos en el proceso formativo personal, posibilitando que las personas sientan responsabilidad por su desarrollo. Para fomentar la participación social es importante motivarlas desde las emociones, para que sean capaces de implicarse en las circunstancias políticas, sociales y culturales de la sociedad civil. En este trabajo, y con el fin de fundamentar empíricamente nuestro planteamiento, describimos el desarrollo de una experiencia universitaria de participación socioeducativa que nos permite valorar el papel de los movimientos sociales en nuestro actual contexto sociocultural.

  6. Diferencias cualitativas entre experiencias tutoriales para opciones de aprendizaje universitario

    Directory of Open Access Journals (Sweden)

    Ángel J. LÁZARO MARTÍNEZ

    2008-01-01

    Full Text Available Se analiza la tutoría como elemento básico de la excelencia educativa, resaltando su carácter nuclear en todo proceso formativo institucionalizado. Se constata la relación entre los procesos educativos, la orientación y la tutoría, desde el nuevo enfoque de la auténtica orientación. En el contexto universitario se debaten sus competencias, destacando que, desde sus orígenes, la tutoría ha constituido el sentido de la función y el quehacer de la finalidad y optimización de la formación universitaria, tanto en la búsqueda del saber como en la pretensión de aplicación social. Esta situación aboca en el análisis de las opciones de la acción tutorial en la Universidad, sus modalidades y sus posibilidades de intervención, y se plantean, de forma más concreta, recogiendo las experiencias destacables en el ámbito universitario, las estrategias organizativas y de desarrollo en aulas y situaciones individualizadas.

  7. APRENDIZAJE BASADO EN PROBLEMAS (ABP: UNA EXPERIENCIA PEDAGOGICA EN MEDICINA

    Directory of Open Access Journals (Sweden)

    Claudio Lermanda S.

    2007-01-01

    Full Text Available La enseñanza tradicional de la Medicina ha sido cuestionada por el avance tecnológico y el exponencial aumento de información médica accesible, obligando a reformular los curricula médicos bajo la mirada de las reformas educacionales que a escala global vienen desarrollándose desde el Proceso de Bolonia. Una propuesta curricular nueva señalada por Harden (1984 y conocida como modelo SPICES permite incorporar una metodología didáctica más apropiada para el proceso de enseñanza - aprendizaje formativo e integrador que demanda la sociedad actual. En este nuevo escenario, muchas Facultades de Medicina han incorporado el Aprendizaje Basado en Problemas (ABP como herramienta de aproximación al modelo señalado, por su carácter integrador de conocimientos, destrezas y actitudes que facilitan la adquisición de las competencias clínicas necesarias para el ejercicio profesional futuro. Este trabajo resume las consideraciones y sugerencias relativas al modelo y a la metodología tras una experiencia de dos años de ABP en la Facultad de Medicina de la Universidad Católica de la Santísima Concepción.

  8. Crisis e intercooperación. La experiencia uruguaya

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    Siegbert Rippe

    2010-12-01

    Full Text Available La presente colaboración, cuya temática central es exponer la forma, modo y oportunidad en que eventual o potencialmente operó la intercooperación como medio instrumental utilizado para respaldar —y superar en su caso— el impacto de la crisis económica mundial en el espacio geopolítico de la República Oriental del Uruguay, plantea los efectos y secuelas de dicha crisis en dicho país observándose, no obstante, la absoluta relatividad de aquel impacto en ese espacio y en la realidad cooperativa, la práctica inexistencia de casos específicos o constatables de intercooperación, en tanto no fueran estrictamente necesarios a aquella finalidad, las positivas previsiones legales contenidas en la nueva, reciente normativa cooperativa, en relación a la promoción de la intercooperación e integración cooperativas, algunas interesantes experiencias de desarrollo de cooperativas en el crítico período considerado (2008-2009, todo la cual se cierra con algunas consideraciones a modo de conclusión relacionadas con la aptitud de la intercooperación y de la integración como medios —y como fines— para el progreso del cooperativismo en lo económico y en lo social.Recibido: 20.05.10Aceptado: 28.06.10

  9. Referéndum en Costa Rica: la primera experiencia

    Directory of Open Access Journals (Sweden)

    Max Alberto Esquivel Faerron

    2008-07-01

    Full Text Available El artículo aborda los distintos mecanismos de democracia directa regulados en el ordenamiento jurídico costarricense, profundizando en el instituto del referéndum. Se centra en analizar, con apoyo en datos estadísticos, la primera experiencia de la aplicación del referéndum en Costa Rica, relativo a la aprobación del Tratado de Libre Comercio entre República Dominicana, Centroamérica y Estados Unidos. Como parte de este estudio, el autor desarrolla, desde el punto de vista doctrinario y de derecho comparado, temas medulares del referéndum que fueron motivo de amplia discusión, tales como: el carácter excepcional de este instituto -contra poniéndolo con el listado de las solicitudes de recolección de firmas presentadas ante el Tribunal-, la fiscalización del proceso, la posición del Poder Ejecutivo a favor de una de las tesis en contienda, el financiamiento de las campañas propagandísticas, la información ciudadana sobre el tema de la consulta y la participación de los medios de comunicación.

  10. Los valores en el deporte: una experiencia educativa a través del Barça-Madrid Values in sport: a pedagogical experience with the football match Barça-Madrid

    Directory of Open Access Journals (Sweden)

    Xavier Ginesta Portet

    2007-03-01

    Full Text Available El deporte ejerce mucha influencia en nuestra sociedad; y, sobre todo, entre los más jóvenes, quienes consumen deporte no sólo en las escuelas, sino también a través de los medios de comunicación. En algunos casos, los valores que los maestros y entrenadores intentan transmitir a sus alumnos o deportistas son diferentes que los valores que transmite el deporte-espectáculo consumido en directo o a través de los medios. En este artículo se relata, a partir del derbi de fútbol Barça-Madrid, una experiencia para intentar desarrollar la capacidad crítica del alumno respecto al deporte. Sport is very influential in our societies; above all, on youngsters. Young consumers are exposed to sport, not only at school, but also through the mass media. Sometimes, the values that teachers and coaches instil in their young pupils, sportsmen and sportswomen, are not the same values which they receive when they watch sport-entertainment events, through mass media or live. In this paper, we analyse an experience, a Barça-Madrid derby, to try to develop the critical capability of students regarding sport.

  11. Elaboración y trabajo con casos y otras metodologías activas. Cuatro experiencias de un grupo de profesores de la Facultad de Educación de Zaragoza

    Directory of Open Access Journals (Sweden)

    Santos OREJUDO HERNÁNDEZ

    2008-01-01

    Full Text Available La formación del profesorado implica un proceso individual de aprendizaje mediado, que dé lugar a un profesional competente y reflexivo. Requiere, además de la incorporación de un corpus de conocimientos, el desarrollo de habilidades y destrezas propias de la profesión. Aprender a "saber hacer", fuera del contexto real, la escuela, no es una tarea fácil para los estudiantes de magisterio. En este artículo presentamos nuestra experiencia en el desarrollo de competencias en la formación inicial del profesorado usando metodologías activas, basadas en el aprendizaje en grupo cooperativo y en el uso de casos, problemas y proyectos. Describimos el proceso que hemos seguido en cuatro asignaturas en las que partiendo del trabajo previo de cada profesor hemos ido desarrollando distintos aspectos metodológicos a partir del trabajo conjunto de profesores implicados en distintos proyectos de innovación docente. Algunos aspectos que han resultado claves en las nuevas y no tan nuevas propuestas metodológicas han sido atender a los requerimientos profesionales que se pretendían desarrollar con las asignaturas, buscar metodologías que acerquen a los estudiantes a la práctica profesional o mejorar la evaluación y convertirla en una herramienta más de aprendizaje.

  12. Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses

    Science.gov (United States)

    Zhao, Lina; Fu, Zhuo; Wu, Jing; Aylor, Kevin W; Barrett, Eugene J; Cao, Wenhong; Liu, Zhenqi

    2015-01-01

    Abstract Hypoadiponectinaemia is closely associated with endothelial dysfunction and insulin resistance, and microvasculature plays a critical role in the regulation of insulin action in muscle. Here we tested whether adiponectin replenishment could improve metabolic insulin sensitivity in male rats fed a high-fat diet (HFD) via the modulation of microvascular insulin responses. Male Sprague–Dawley rats were fed either a HFD or low-fat diet (LFD) for 4 weeks. Small resistance artery myograph changes in tension, muscle microvascular recruitment and metabolic response to insulin were determined. Compared with rats fed a LFD, HFD feeding abolished the vasodilatory actions of globular adiponectin (gAd) and insulin on pre-constricted distal saphenous arteries. Pretreatment with gAd improved insulin responses in arterioles isolated from HFD rats, which was blocked by AMP-activated protein kinase (AMPK) inhibition. Similarly, HFD abolished microvascular responses to either gAd or insulin and decreased insulin-stimulated glucose disposal by ∼60%. However, supplementing gAd fully rescued insulin’s microvascular action and significantly improved the metabolic responses to insulin in HFD male rats and these actions were abolished by inhibition of either AMPK or nitric oxide production. We conclude that HFD induces vascular adiponectin and insulin resistance but gAd administration can restore vascular insulin responses and improve insulin’s metabolic action via an AMPK- and nitric oxide-dependent mechanism in male rats. Key points Adiponectin is an adipokine with anti-inflammatory and anti-diabetic properties. Hypoadiponectinaemia is closely associated with endothelial dysfunction and insulin resistance in obesity and diabetes. Insulin resistance is present in muscle microvasculature and this may contribute to decreased insulin delivery to, and action in, muscle. In this study we examined whether adiponectin ameliorates metabolic insulin resistance by affecting muscle

  13. Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: a principal component analysis approach.

    Science.gov (United States)

    Panazzolo, Diogo G; Sicuro, Fernando L; Clapauch, Ruth; Maranhão, Priscila A; Bouskela, Eliete; Kraemer-Aguiar, Luiz G

    2012-11-13

    We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements. Data from 189 female subjects (34.0 ± 15.5 years, 30.5 ± 7.1 kg/m2), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical multivariate exploratory tool because it highlights common variation between variables allowing inferences about possible biological meaning of associations between them, without pre-establishing cause-effect relationships. In total, 15 variables were used for PCA: body mass index (BMI), waist circumference, systolic and diastolic blood pressure (BP), fasting plasma glucose, levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), insulin, C-reactive protein (CRP), and functional microvascular variables measured by nailfold videocapillaroscopy. Nailfold videocapillaroscopy was used for direct visualization of nutritive capillaries, assessing functional capillary density, red blood cell velocity (RBCV) at rest and peak after 1 min of arterial occlusion (RBCV(max)), and the time taken to reach RBCV(max) (TRBCV(max)). A total of 35% of subjects had metabolic syndrome, 77% were overweight/obese, and 9.5% had impaired fasting glucose. PCA was able to recognize that functional microvascular variables and clinical-laboratorial-anthropometrical measurements had a similar variation. The first five principal components explained most of the intrinsic variation of the data. For example, principal component 1 was associated with BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP, and TRBCV(max) varying in the same way. Principal component 1 also showed a strong association among HDL-c, RBCV, and RBCV(max), but in the opposite way. Principal component 3 was associated only with microvascular

  14. Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: a principal component analysis approach

    Directory of Open Access Journals (Sweden)

    Panazzolo Diogo G

    2012-11-01

    Full Text Available Abstract Background We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements. Methods Data from 189 female subjects (34.0±15.5 years, 30.5±7.1 kg/m2, who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA. PCA is a classical multivariate exploratory tool because it highlights common variation between variables allowing inferences about possible biological meaning of associations between them, without pre-establishing cause-effect relationships. In total, 15 variables were used for PCA: body mass index (BMI, waist circumference, systolic and diastolic blood pressure (BP, fasting plasma glucose, levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c, low-density lipoprotein cholesterol (LDL-c, triglycerides (TG, insulin, C-reactive protein (CRP, and functional microvascular variables measured by nailfold videocapillaroscopy. Nailfold videocapillaroscopy was used for direct visualization of nutritive capillaries, assessing functional capillary density, red blood cell velocity (RBCV at rest and peak after 1 min of arterial occlusion (RBCVmax, and the time taken to reach RBCVmax (TRBCVmax. Results A total of 35% of subjects had metabolic syndrome, 77% were overweight/obese, and 9.5% had impaired fasting glucose. PCA was able to recognize that functional microvascular variables and clinical-laboratorial-anthropometrical measurements had a similar variation. The first five principal components explained most of the intrinsic variation of the data. For example, principal component 1 was associated with BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP, and TRBCVmax varying in the same way. Principal component 1 also showed a strong association among HDL-c, RBCV, and RBCVmax, but in the opposite way. Principal component 3 was

  15. Microvascular resistance of the culprit coronary artery in acute ST-elevation myocardial infarction

    Science.gov (United States)

    Carrick, David; Haig, Caroline; Carberry, Jaclyn; McCartney, Peter; Welsh, Paul; Ahmed, Nadeem; McEntegart, Margaret; Petrie, Mark C.; Eteiba, Hany; Lindsay, Mitchell; Hood, Stuart; Watkins, Stuart; Rauhalammi, Samuli M.O.; Mordi, Ify; Ford, Ian; Radjenovic, Aleksandra; Sattar, Naveed; Oldroyd, Keith G.

    2016-01-01

    BACKGROUND. Failed myocardial reperfusion is common and prognostically important after acute ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate coronary flow reserve (CFR), a measure of vasodilator capacity, and the index of microvascular resistance (IMR; mmHg × s) in the culprit artery of STEMI survivors. METHODS. IMR (n = 288) and CFR (n = 283; mean age [SD], 60 [12] years) were measured acutely using guide wire–based thermodilution. Cardiac MRI disclosed left ventricular pathology, function, and volumes at 2 days (n = 281) and 6 months after STEMI (n = 264). All-cause death or first heart failure hospitalization was independently adjudicated (median follow-up 845 days). RESULTS. Myocardial hemorrhage and microvascular obstruction occurred in 89 (42%) and 114 (54%) patients with evaluable T2*-MRI maps. IMR and CFR were associated with microvascular pathology (none vs. microvascular obstruction only vs. microvascular obstruction and myocardial hemorrhage) (median [interquartile range], IMR: 17 [12.0–33.0] vs. 17 [13.0–39.0] vs. 37 [21.0–63.0], P < 0.001; CFR: 1.7 [1.4–2.5] vs. 1.5 [1.1–1.8] vs. 1.4 [1.0–1.8], P < 0.001), whereas thrombolysis in myocardial infarction blush grade was not. IMR was a multivariable associate of changes in left ventricular end-diastolic volume (regression coefficient [95% CI] 0.13 [0.01, 0.24]; P = 0.036), whereas CFR was not (P = 0.160). IMR (5 units) was a multivariable associate of all-cause death or heart failure hospitalization (n = 30 events; hazard ratio [95% CI], 1.09 [1.04, 1.14]; P < 0.001), whereas CFR (P = 0.124) and thrombolysis in myocardial infarction blush grade (P = 0.613) were not. IMR had similar prognostic value for these outcomes as <50% ST-segment resolution on the ECG. CONCLUSIONS. IMR is more closely associated with microvascular pathology, left ventricular remodeling, and health outcomes than the angiogram or CFR. TRIAL REGISTRATION. NCT02072850. FUNDING. A

  16. Alcohol consumption and risk of microvascular complications in type 1 diabetes patients; the EURODIAB Prospective Complications study

    NARCIS (Netherlands)

    Beulens, J.W.J.; Kruidhof, J.S.; Grobbee, D.E.; Chaturvedi, N.; Fuller, J.H.; Soedamah-Muthu, S.S.

    2008-01-01

    AIMS/HYPOTHESIS: The aim of this study was to investigate the association between alcohol consumption and risk of microvascular complications (retinopathy, neuropathy, nephropathy) in type 1 diabetes mellitus patients in the EURODIAB Prospective Complications Study. METHODS: The EURODIAB Prospective

  17. Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators.

    Science.gov (United States)

    Ghosh, Anshuman; Freestone, Nicholas S; Anim-Nyame, Nicholas; Arrigoni, Francesca I F

    2017-04-01

    In preeclampsia, maternal microvascular function is disrupted and angiogenesis is dysfunctional. Insulin resistance that occurs in some pregnancies also pathologically affects microvascular function. We wished to examine the relationship of angiogenic mediators and insulin resistance on microvascular health in pregnancy. We performed a nested, case-control study of 16 women who developed preeclampsia with 17 normal pregnant controls. We hypothesized that the impaired microvascular blood flow in preeclamptic women associated with an increased ratio of the antiangiogenic factors; (s-endoglin [sEng] and soluble fms-like tyrosine kinase-1 [sFlt-1]) and proangiogenic molecule (placental growth factor [PlGF]) could be influenced by insulin resistance. Serum samples taken after 28 weeks of gestation were measured for the angiogenic factors, insulin, and glucose alongside the inflammatory marker; tumor necrosis factor-α and endothelial activation, namely; soluble vascular cell adhesion molecule 1, intercellular adhesion molecule-1, and e-selectin. Maternal microvascular blood flow, measured by strain gauge plethysmography, correlated with ratios of pro- and antiangiogenic mediators independently of preeclampsia. Decreased microvascular function measured in preeclampsia strongly correlated with both the antiangiogenic factor (sFlt-1 + sEng): PlGF ratio and high levels of insulin resistance, and combining insulin resistance with antiangiogenic factor ratios further strengthened this relationship. In pregnancy, microvascular blood flow is strongly associated with perturbations in pro- and antiangiogenic mediators. In preeclampsia, the relationship of maternal microvascular dysfunction with antiangiogenic mediators is strengthened when combined with insulin resistance. © 2017 Kingston University. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  18. The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Bianca Harris

    Full Text Available Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1 (P<0.001 and FEV(1/forced vital capacity (FVC ratio (P = 0.04. Albumin-to-creatinine ratio was inversely associated with FEV(1 (P = 0.002 but not FEV(1/FVC. Myocardial blood flow (n = 126 was associated with lower FEV(1 (P = 0.02, lower FEV(1/FVC (P = 0.001 and greater percentage LAA (P = 0.04. Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.

  19. ¿Con qué saboreamos?: tareas y experiencias para un taller de ciencias

    Directory of Open Access Journals (Sweden)

    Sánchez Ramos, M.A.

    2008-04-01

    Full Text Available En un grupo de primero de primaria hicimos una pregunta aparentemente simple: ¿Con qué saboreamos? La respuesta inmediata entre los niños fue “con la lengua” y, aunque ésta no fue totalmente correcta, sirvió para iniciar un proyecto en el que se ofreció a los niños la oportunidad para observar, proponer hipótesis, establecerobjetivos y buscar métodos que les ayudaran a resolver la pregunta. Planteamos 4 experiencias cuya finalidad fue que los niños extendieran sus conocimientos y su comprensión sobre un proceso aparentemente sencillo como es la percepción al sabor. Primero cuestionamos la idea de que fuera la lengua el lugar primordial para la detección del sabor (experiencia 1; después incluimos al sentido del olfato como parte de la percepción del sabor (experiencia 2; tratamos de convencer a los niños de que el olor es el elemento más importante para detectar el sabor (experiencia 3; por último discutimos la posibilidad de que fuera el cerebro el que realmente saborea (experiencia 4.

  20. ¿Con qué saboreamos?: tareas y experiencias para un taller de ciencias

    Directory of Open Access Journals (Sweden)

    Marco A. Sánchez Ramos

    2008-01-01

    Full Text Available En un grupo de primero de primaria hicimos una pregunta aparentemente simple: ¿Con qué saboreamos? La respuesta inmediata entre los niños fue "con la lengua" y, aunque ésta no fue totalmente correcta, sirvió para iniciar un proyecto en el que se ofreció a los niños la oportunidad para observar, proponer hipótesis, establecer objetivos y buscar métodos que les ayudaran a resolver la pregunta. Planteamos 4 experiencias cuya finalidad fue que los niños extendieran sus conocimientos y su comprensión sobre un proceso aparentemente sencillo como es la percepción al sabor. Primero cuestionamos la idea de que fuera la lengua el lugar primordial para la detección del sabor (experiencia 1; después incluimos al sentido del olfato como parte de la percepción del sabor (experiencia 2; tratamos de convencer a los niños de que el olor es el elemento más importante para detectar el sabor (experiencia 3; por último discutimos la posibilidad de que fuera el cerebro el que realmente saborea (experiencia 4.

  1. Fluid resuscitation following a burn injury: implications of a mathematical model of microvascular exchange.

    Science.gov (United States)

    Bert, J; Gyenge, C; Bowen, B; Reed, R; Lund, T

    1997-03-01

    A validated mathematical model of microvascular exchange in thermally injured humans has been used to predict the consequences of different forms of resuscitation and potential modes of action of pharmaceuticals on the distribution and transport of fluid and macromolecules in the body. Specially, for 10 and/or 50 per cent burn surface area injuries, predictions are presented for no resuscitation, resuscitation with the Parkland formula (a high fluid and low protein formulation) and resuscitation with the Evans formula (a low fluid and high protein formulation). As expected, Parkland formula resuscitation leads to interstitial accumulation of excess fluid, while use of the Evans formula leads to interstitial accumulation of excessive amounts of proteins. The hypothetical effects of pharmaceuticals on the transport barrier properties of the microvascular barrier and on the highly negative tissue pressure generated postburn in the injured tissue were also investigated. Simulations predict a relatively greater amelioration of the acute postburn edema through modulation of the postburn tissue pressure effects.

  2. Alternative wavelengths for sutureless laser microvascular anastomosis: a preliminary study on acute samples.

    Science.gov (United States)

    Bass, L S; Oz, M C; Libutti, S K; Treat, M R

    1992-06-01

    Attempts to improve the speed and patency of microvascular anastomosis with laser-assisted techniques have provided a modest reduction in operative time and comparable success rates. Using sutureless microvascular anastomoses, 30 end-to-end anastomoses were created in the rat carotid artery using the gallium-aluminum-arsenide diode laser (808 nm). Indocyanine green and fibrinogen were applied to enhance tissue absorption of the laser energy and strengthen the bond created. These were compared with previously reported welds using the THC:YAG laser (2150 nm). Mean welding times were 140 and 288 s, and mean bursting pressures immediately after welding were 515 and 400 mmHg for the diode and THC:YAG laser groups, respectively. Histologically, both lateral and vertical spread of thermal damage was limited. Since both lasers create welds of adequate initial strength without stay sutures and are faster and easier to use than existing systems, evaluation of long-term patency would be worthwhile.

  3. [Successful microvascular decompression of the medulla oblongata for a case with respiratory failure: case report].

    Science.gov (United States)

    Koguchi, Motofumi; Nakahara, Yukiko; Kawashima, Masatou; Takase, Yukinori; Matsushima, Toshio

    2011-11-01

    We report a case of the medulla oblongata syndrome successfully treated by microvascular decompression surgery. The patient was a 75-year-old woman and had been suffering from gradual progressive dyspnea since July, 2009. Two month later, intubation and medial ventilator treatments were began because of severe respiratory problems. The central respiratory problems were considered in extensive testing by the physician. The head MR imaging showed that the left vertebral artery had markedly compressed the medulla oblongata. We thought that her respiratory problems were associated with this vertebral artery compression of the medulla oblongata. We performed the microvascular decompression surgery by left trans-condylar fossa approach. Her hypoventilation graduately improved after the surgery and she needed neither ventilator nor oxygen in several months. She is able to perform daily activities by herself. We report the case, and discuss the cause of respiratory problems especially by compression of the medulla oblongata.

  4. A model of physical factors in the structural adaptation of microvascular networks in normotension and hypertension

    DEFF Research Database (Denmark)

    Jacobsen, Jens Christian Brings; Gustafsson, Finn; Holstein-Rathlou, N.-H.

    2003-01-01

    Adequate function of the microcirculation is vital to any tissue. To maintain an optimal function, microvascular networks must be able to adapt structurally to changes in the physical environment. Here we present a mathematical network model based on vessel wall mechanics. We assume based...... diameter, until equilibrium is restored. The model explains several of the key features observed experimentally in the microcirculation in normotension and hypertension. Most importantly, it suggests a scenario where overall network structure and network hemodynamics depend on adaptation to local...... hemodynamic stimuli in the individual vessel. Simulated results show emanating microvascular networks with properties similar to those observed in vivo. The model points to an altered endothelial function as a key factor in the development of vascular changes characteristic of hypertension....

  5. Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data

    DEFF Research Database (Denmark)

    Munk, O L; Keiding, S; Bass, L

    2003-01-01

    estimation of parameters in models with more physiological realism. We explore the standard compartmental model and find that incorporation of blood flow leads to paradoxes, such as kinetic rate constants being time-dependent, and tracers being cleared from a capillary faster than they can be supplied...... single- and multi-capillary systems and include effects of non-exchanging vessels. They are suitable for analysing dynamic PET data from any capillary bed using either intravascular or diffusible tracers, in terms of physiological parameters which include regional blood flow. Udgivelsesdato: 2003-Nov-7...... by blood flow. The inability of the standard model to incorporate blood flow consequently raises a need for models that include more physiology, and we develop microvascular models which remove the inconsistencies. The microvascular models can be regarded as a revision of the input function. Whereas...

  6. Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms

    Directory of Open Access Journals (Sweden)

    Karl Heckler

    2017-09-01

    Full Text Available Diabetes mellitus (DM is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today’s medicine. Zebrafish is an upcoming disease model organism in diabetes research. Its glucose metabolism and the pathways of reactive metabolite formation are very similar to those of humans. Moreover, several physiological and pathophysiological pathways that also exist in humans and other mammals have been identified in this species or are currently under intense investigation. Zebrafish offer sophisticated imaging techniques and allow simple and fast genetic and pharmacological approaches with a high throughput. In this review, we highlight achievements and mechanisms concerning microvascular complications discovered in zebrafish, and we discuss the advantages and disadvantages of zebrafish as a model for studying diabetic complications.

  7. Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro: tissue engineering implications.

    Science.gov (United States)

    Fortunato, Tiago M; Beltrami, Cristina; Emanueli, Costanza; De Bank, Paul A; Pula, Giordano

    2016-05-04

    Revascularisation is a key step for tissue regeneration and complete organ engineering. We describe the generation of human platelet lysate gel (hPLG), an extracellular matrix preparation from human platelets able to support the proliferation of endothelial colony forming cells (ECFCs) in 2D cultures and the formation of a complete microvascular network in vitro in 3D cultures. Existing extracellular matrix preparations require addition of high concentrations of recombinant growth factors and allow only limited formation of capillary-like structures. Additional advantages of our approach over existing extracellular matrices are the absence of any animal product in the composition hPLG and the possibility of obtaining hPLG from patients to generate homologous scaffolds for re-implantation. This discovery has the potential to accelerate the development of regenerative medicine applications based on implantation of microvascular networks expanded ex vivo or the generation of fully vascularised organs.

  8. Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

    DEFF Research Database (Denmark)

    Shanbhogue, Vikram Vinod; Hansen, Stinus; Nielsen, Morten Frost Munk

    2016-01-01

    OBJECTIVE AND DESIGN: Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone...... remodeling in T2D patients with and without diabetic microvascular disease (MVD+ and MVD- respectively) and to compare them with healthy controls. METHODS: Fifty-one T2D patients (MVD+ group: n=25) were recruited from Funen Diabetic Database and matched for age, sex and height with 51 healthy subjects. High...... deficits are not a characteristic of all T2D patients but of a subgroup characterized by the presence of microvascular complications. Whether this influences fracture rates in these patients needs further investigation....

  9. Tumor necrosis factor-alpha increases myocardial microvascular transport in vivo

    DEFF Research Database (Denmark)

    Hansen, P R; Svendsen, Jesper Hastrup; Høyer, S

    1994-01-01

    Tumor necrosis factor-alpha (TNF-alpha) is a primary mediator in the pathogenesis of tissue injury, and high circulating levels of TNF-alpha are found in a variety of pathological conditions. In open-chest anesthetized dogs, the effects of intracoronary recombinant human TNF-alpha (rTNF-alpha; 100...... in cardiac output and was associated with the appearance of areas with myocardial necrosis in the regional left ventricular wall. The myocardial plasma flow rate and maximum plasma flow rate in response to a 30-s coronary occlusion were not influenced by rTNF-alpha, although a decrease in the myocardial...... ng/kg for 60 min) on myocardial microvascular transport of a small hydrophilic indicator was examined by the single-injection, residue-detection method. Intracoronary infusion of rTNF-alpha increased myocardial microvascular transport after 120 min. This increase was preceded by a sustained decline...

  10. Time-Dependent Behavior of Microvascular Blood Flow and Oxygenation: A Predictor of Functional Outcomes.

    Science.gov (United States)

    Kuliga, Katarzyna Z; Gush, Rodney; Clough, Geraldine F; Chipperfield, Andrew John

    2018-05-01

    This study investigates the time-dependent behaviour and algorithmic complexity of low-frequency periodic oscillations in blood flux (BF) and oxygenation signals from the microvasculature. Microvascular BF and oxygenation (OXY: oxyHb, deoxyHb, totalHb, and SO 2 %) was recorded from 15 healthy young adult males using combined laser Doppler fluximetry and white light spectroscopy with local skin temperature clamped to 33  °C and during local thermal hyperaemia (LTH) at 43 °C. Power spectral density of the BF and OXY signals was evaluated within the frequency range (0.0095-1.6 Hz). Signal complexity was determined using the Lempel-Ziv (LZ) algorithm. Fold increase in BF during LTH was 15.6 (10.3, 22.8) and in OxyHb 4.8 (3.5, 5.9) (median, range). All BF and OXY signals exhibited multiple oscillatory components with clear differences in signal power distribution across frequency bands at 33 and 43 °C. Significant reduction in the intrinsic variability and complexity of the microvascular signals during LTH was found, with mean LZ complexity of BF and OxyHb falling by 25% and 49%, respectively ( ). These results provide corroboration that in human skin microvascular blood flow and oxygenation are influenced by multiple time-varying oscillators that adapt to local influences and become more predictable during increased haemodynamic flow. Recent evidence strongly suggests that the inability of microvascular networks to adapt to an imposed stressor is symptomatic of disease risk which might be assessed via BF and OXY via the combination signal analysis techniques described here.

  11. Restrictive use of perioperative blood transfusion does not increase complication rates in microvascular breast reconstruction.

    Science.gov (United States)

    O'Neill, Anne C; Barandun, Marina; Cha, Jieun; Zhong, Toni; Hofer, Stefan O P

    2016-08-01

    With increasing appreciation of the possible adverse effects of peri-operative blood transfusion, restrictive policies regarding use of blood products have been adopted in many surgical specialties. Although microvascular breast reconstruction has become a routine procedure, high peri-operative transfusion rates continue to be reported in the literature. In this study we examine the impact of our restrictive approach on blood transfusion rates and postoperative complications in patients undergoing microvascular blood transfusion. A retrospective review of patients undergoing microvascular breast reconstruction with abdominal flaps at a single institution was performed. Patient age and body mass index as well as type, timing and laterality of reconstruction was recorded. Pre-operative and post-operative hemoglobin and hematocrit were recorded. Peri-operative blood transfusion rates were calculated. Post-operative complication rates were compared between patients with higher and lower post-operative hemoglobin levels. Five hundred and twelve patients were included in this study. The peri-operative transfusion rate was 0.98% in this series. There was no significant difference between transfusion rates in unilateral and bilateral reconstructions (0.68 vs 1.36% p = 0.08) or immediate and delayed reconstructions (1.02 vs 0.51% p = 0.72 and 1.01 vs 1.60% p = 0.09 for unilateral and bilateral respectively). Lower post-operative hemoglobin levels were not associated with increased flap related, surgical or medical complications rates. A restrictive approach to peri-operative blood transfusion can be safely adopted in microvascular breast reconstruction without compromising flap viability or overall complication rates. Copyright © 2016 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  12. Microvascular anastomosis simulation using a chicken thigh model: Interval versus massed training.

    Science.gov (United States)

    Schoeff, Stephen; Hernandez, Brian; Robinson, Derek J; Jameson, Mark J; Shonka, David C

    2017-11-01

    To compare the effectiveness of massed versus interval training when teaching otolaryngology residents microvascular suturing on a validated microsurgical model. Otolaryngology residents were placed into interval (n = 7) or massed (n = 7) training groups. The interval group performed three separate 30-minute practice sessions separated by at least 1 week, and the massed group performed a single 90-minute practice session. Both groups viewed a video demonstration and recorded a pretest prior to the first training session. A post-test was administered following the last practice session. At an academic medical center, 14 otolaryngology residents were assigned using stratified randomization to interval or massed training. Blinded evaluators graded performance using a validated microvascular Objective Structured Assessment of Technical Skill tool. The tool is comprised of two major components: task-specific score (TSS) and global rating scale (GRS). Participants also received pre- and poststudy surveys to compare subjective confidence in multiple aspects of microvascular skill acquisition. Overall, all residents showed increased TSS and GRS on post- versus pretest. After completion of training, the interval group had a statistically significant increase in both TSS and GRS, whereas the massed group's increase was not significant. Residents in both groups reported significantly increased levels of confidence after completion of the study. Self-directed learning using a chicken thigh artery model may benefit microsurgical skills, competence, and confidence for resident surgeons. Interval training results in significant improvement in early development of microvascular anastomosis skills, whereas massed training does not. NA. Laryngoscope, 127:2490-2494, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  13. Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.

    Science.gov (United States)

    Stanhewicz, Anna E; Jandu, Sandeep; Santhanam, Lakshmi; Alexander, Lacy M

    2017-08-01

    Women who have had preeclampsia have increased cardiovascular disease risk; however, the mechanism(s) responsible for this association remain unclear. Microvascular damage sustained during a preeclamptic pregnancy may persist postpartum. The putative mechanisms mediating this dysfunction include a reduction in NO-dependent dilation and an increased sensitivity to angiotensin II. In this study, we evaluated endothelium-dependent dilation, angiotensin II sensitivity, and the therapeutic effect of angiotensin II receptor blockade (losartan) on endothelium-dependent dilation in vivo in the microvasculature of women with a history of preeclampsia (n=12) and control women who had a healthy pregnancy (n=12). We hypothesized that preeclampsia would have (1) reduced endothelium-dependent dilation, (2) reduced NO-mediated dilation, and (3) increased sensitivity to angiotensin II. We further hypothesized that localized losartan would increase endothelium-dependent vasodilation in preeclampsia. We assessed microvascular endothelium-dependent vasodilator function by measurement of cutaneous vascular conductance responses to graded infusion of acetylcholine (acetylcholine; 10 -7 -102 mmol/L) and a standardized local heating protocol in control sites and sites treated with 15 mmol/L L-NAME ( N G -nitro-l-arginine methyl ester; NO-synthase inhibitor) or 43 µmol/L losartan. Further, we assessed microvascular vasoconstrictor sensitivity to angiotensin II (10 -20 -10 -4 mol/L). Preeclampsia had significantly reduced endothelium-dependent dilation (-0.3±0.5 versus -1.0±0.4 log EC50 ; P Preeclampsia also had augmented vasoconstrictor sensitivity to angiotensin II (-10.2±1.3 versus -8.3±0.5; P =0.006). Angiotensin II type I receptor inhibition augmented endothelium-dependent vasodilation and NO-dependent dilation in preeclampsia but had no effect in healthy pregnancy. These data suggest that women who have had preeclampsia have persistent microvascular dysfunction postpartum

  14. TRANSFUSION RESTORES BLOOD VISCOSITY AND REINSTATES MICROVASCULAR CONDITIONS FROM HEMORRHAGIC SHOCK INDEPENDENT OF OXYGEN CARRYING CAPACITY

    OpenAIRE

    Cabrales, Pedro; Intaglietta, Marcos; Tsai, Amy G.

    2007-01-01

    Systemic and microvascular hemodynamic responses to transfusion of oxygen using functional and non-functional packed fresh red blood cells (RBCs) from hemorrhagic shock were studied in the hamster window chamber model to determine the significance of RBCs on rheological and oxygen transport properties. Moderate hemorrhagic shock was induced by arterial controlled bleeding of 50% of the blood volume, and a hypovolemic state was maintained for one hour. Volume restitution was performed by infus...

  15. Effect of Antimicrobial Compounds on Balamuthia mandrillaris Encystment and Human Brain Microvascular Endothelial Cell Cytopathogenicity▿

    Science.gov (United States)

    Siddiqui, Ruqaiyyah; Matin, Abdul; Warhurst, David; Stins, Monique; Khan, Naveed Ahmed

    2007-01-01

    Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment. PMID:17875991

  16. Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase.

    Science.gov (United States)

    Kuebler, Wolfgang M; Wittenberg, Claudia; Lee, Warren L; Reppien, Eike; Goldenberg, Neil M; Lindner, Karsten; Gao, Yizhuo; Winoto-Morbach, Supandi; Drab, Marek; Mühlfeld, Christian; Dombrowsky, Heike; Ochs, Matthias; Schütze, Stefan; Uhlig, Stefan

    2016-04-15

    Transcellular albumin transport occurs via caveolae that are abundant in lung microvascular endothelial cells. Stimulation of albumin transcytosis by proinflammatory mediators may contribute to alveolar protein leak in lung injury, yet the regulation of albumin transport and its underlying molecular mechanisms are so far incompletely understood. Here we tested the hypothesis that thrombin may stimulate transcellular albumin transport across lung microvascular endothelial cells in an acid-sphingomyelinase dependent manner. Thrombin increased the transport of fluorescently labeled albumin across confluent human lung microvascular endothelial cell (HMVEC-L) monolayers to an extent that markedly exceeds the rate of passive diffusion. Thrombin activated acid sphingomyelinase (ASM) and increased ceramide production in HMVEC-L, but not in bovine pulmonary artery cells, which showed little albumin transport in response to thrombin. Thrombin increased total caveolin-1 (cav-1) content in both whole cell lysates and lipid rafts from HMVEC-L, and this effect was blocked by inhibition of ASM or de novo protein biosynthesis. Thrombin-induced uptake of albumin into lung microvascular endothelial cells was confirmed in isolated-perfused lungs by real-time fluorescence imaging and electron microscopy of gold-labeled albumin. Inhibition of ASM attenuated thrombin-induced albumin transport both in confluent HMVEC-L and in intact lungs, whereas HMVEC-L treatment with exogenous ASM increased albumin transport and enriched lipid rafts in cav-1. Our findings indicate that thrombin stimulates transcellular albumin transport in an acid sphingomyelinase-dependent manner by inducing de novo synthesis of cav-1 and its recruitment to membrane lipid rafts. Copyright © 2016 the American Physiological Society.

  17. Induction of complement proteins in a mouse model for cerebral microvascular Aβ deposition

    Directory of Open Access Journals (Sweden)

    DeFilippis Kelly

    2007-09-01

    Full Text Available Abstract The deposition of amyloid β-protein (Aβ in cerebral vasculature, known as cerebral amyloid angiopathy (CAA, is a common pathological feature of Alzheimer's disease and related disorders. In familial forms of CAA single mutations in the Aβ peptide have been linked to the increase of vascular Aβ deposits accompanied by a strong localized activation of glial cells and elevated expression of neuroinflammatory mediators including complement proteins. We have developed human amyloid-β precursor protein transgenic mice harboring two CAA Aβ mutations (Dutch E693Q and Iowa D694N that mimic the prevalent cerebral microvascular Aβ deposition observed in those patients, and the Swedish mutations (K670N/M671L to increase Aβ production. In these Tg-SwDI mice, we have reported predominant fibrillar Aβ along microvessels in the thalamic region and diffuse plaques in cortical region. Concurrently, activated microglia and reactive astrocytes have been detected primarily in association with fibrillar cerebral microvascular Aβ in this model. Here we show that three native complement components in classical and alternative complement pathways, C1q, C3, and C4, are elevated in Tg-SwDI mice in regions rich in fibrillar microvascular Aβ. Immunohistochemical staining of all three proteins was increased in thalamus, hippocampus, and subiculum, but not frontal cortex. Western blot analysis showed significant increases of all three proteins in the thalamic region (with hippocampus as well as the cortical region, except C3 that was below detection level in cortex. Also, in the thalamic region (with hippocampus, C1q and C3 mRNAs were significantly up-regulated. These complement proteins appeared to be expressed largely by activated microglial cells associated with the fibrillar microvascular Aβ deposits. Our findings demonstrate that Tg-SwDI mice exhibit elevated complement protein expression in response to fibrillar vascular Aβ deposition that is

  18. Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

    DEFF Research Database (Denmark)

    Sjøberg, Kim Anker; Frøsig, Christian; Kjøbsted, Rasmus

    2017-01-01

    and increased similarly in both legs during the clamp and L-NMMA had no effect on these insulin-stimulated signaling pathways. Therefore, acute exercise increases insulin sensitivity of muscle by a coordinated increase in insulin-stimulated microvascular perfusion and molecular signaling at the level of TBC1D4...... and glycogen synthase in muscle. This secures improved glucose delivery on the one hand and increased ability to take up and dispose of the delivered glucose on the other hand....

  19. Photocoagulation of microvascular and hemorrhagic lesions of the vocal fold with the KTP laser.

    Science.gov (United States)

    Hirano, Shigeru; Yamashita, Masaru; Kitamura, Morimasa; Takagita, Shin-ichi

    2006-04-01

    Ectasias and varices of the vocal fold are microvascular lesions that are often due to chronic abuse of the voice, and are occasionally encountered in association with other disorders such as polyps, Reinke's edema, and hematoma. The KTP laser can be used for photocoagulation of small vascular lesions, because the laser beam is well absorbed by hemoglobin, and damage to the epithelium is minimal. The present pilot study examined how the KTP laser could be used for microvascular lesions and their associated lesions. Twelve patients who had undergone phonomicrosurgery were enrolled in the present study. The microvascular lesions were treated by photocoagulation with the laser set at a low power of 1.5 W in the continuous mode, while preserving the epithelium, and associated lesions were then treated by microdissection with cold instruments. The postoperative phonatory function was assessed by maximum phonation time, a perceptual test rating (GRBAS scale), and stroboscopy. The procedures were completed successfully in all cases. An exceptional case of a small hemorrhagic polyp allowed treatment with the laser only. The postoperative stroboscopic findings, maximum phonation time, and perceptual test rating all showed significant improvement compared with the preoperative state. No adverse effects, such as scarring or reduction of the mucosal wave, were observed in the current series. KTP laser photocoagulation is a relatively simple and safe procedure for treating microvascular lesions of the vocal fold. It is not recommended for photocoagulation of hemorrhagic polyps or hematomas, because such lesions have little blood flow inside and thus photocoagulation is usually impossible or requires too much laser energy. However, photocoagulation of perimeter or feeding vessels of such disorders may facilitate the following procedure by avoiding unnecessary bleeding, as well as preventing recurrence of hemorrhagic lesions.

  20. Barotrauma and microvascular injury in lungs of nonadult rabbits: effect of ventilation pattern.

    Science.gov (United States)

    Peevy, K J; Hernandez, L A; Moise, A A; Parker, J C

    1990-06-01

    To study the pulmonary microvascular injury produced by ventilation barotrauma, the isolated perfused lungs of 4 to 6-wk-old New Zealand white rabbits were ventilated by one of the following methods: peak inspiratory pressure (PIP) 23 cm H2O, gas flow rate 1.1 L/min (group 1); PIP 27 cm H2O, gas flow rate 6.9 L/min (group 2); PIP 50 cm H2O, gas flow rate 1.9 L/min (group 3); or PIP 53 cm H2O, gas flow rate 8.3 L/min (group 4). Microvascular permeability was assessed using the capillary filtration coefficient (Kfc) before and 5, 30, and 60 min after a 15-min period of ventilation. Baseline Kfc was not significantly different between groups. A significant increase over the baseline Kfc was noted at 60 min in group 2 and in all postventilation Kfc values in groups 3 and 4 (p less than .05). Group 1 Kfc values did not change significantly after ventilation. At all post-ventilation times, values for Kfc were significantly greater in groups 3 and 4 than in group 1 (p less than .05). Group 4 Kfc values were significantly greater than those in group 2 at 5 and 30 min postventilation. These data indicate that high PIP, and to a lesser extent, high gas flow rates cause microvascular injury in the compliant nonadult lung and suggest that the combination of high PIP and high gas flow rates are the most threatening to microvascular integrity.

  1. 3D modelling of the Salesian mission Nuestra Señora de la Candelaria cemetery (Río Grande, Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Melisa A. Salerno

    2017-07-01

    Full Text Available The Salesian mission Nuestra Señora de La Candelaria operated between the late 19th and the mid-20th centuries in Río Grande (Tierra del Fuego, Argentina. Its cemetery still holds the remains of indigenous and religious people who lived in the institution, and settlers who lived nearby. For some years, the place has received the attention of a research project interested in discussing the dynamics of colonial relationships in Tierra del Fuego. The cemetery has a long history of changes, and even though it was declared part of the national and provincial heritage, its preservation conditions are relatively poor. In this article we present the work carried out to produce a 3D model of the cemetery, combining information obtained by planialtimetric and photographic survey. The result represents a detailed and photorealistic record of the materiality of the cemetery at present. Therefore, it does not only provide a relevant tool to colaborate in the promotion and protection of the archaeological heritage. It also provides a platform for future 3D modelling of historical images of the cemetery, with different research goals.

  2. Long-term effects of bariatric surgery on peripheral endothelial function and coronary microvascular function.

    Science.gov (United States)

    Tarzia, Pierpaolo; Lanza, Gaetano A; Sestito, Alfonso; Villano, Angelo; Russo, Giulio; Figliozzi, Stefano; Lamendola, Priscilla; De Vita, Antonio; Crea, Filippo

    We previously demonstrated that bariatric surgery (BS) leads to a short-term significant improvement of endothelial function and coronary microvascular function. In this study we assessed whether BS maintains its beneficial effect at long-term follow up. We studied 19 morbidly obese patients (age 43±9years, 12 women) without any evidence of cardiovascular disease who underwent BS. Patients were studied before BS, at 3 months and at 4.0±1.5years follow up. Peripheral vascular function was assessed by flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD), i.e., brachial artery diameter changes in response to post-ischemic forearm hyperhaemia and to nitroglycerin administration, respectively. Coronary microvascular function was assessed by measuring coronary blood flow (CBF) response to intravenous adenosine and to cold pressor test (CPT) in the left anterior descending coronary artery. Together with improvement of anthropometric and metabolic profile, at long-term follow-up patients showed a significant improvement of FMD (6.43±2.88 vs. 8.21±1.73%, p=0.018), and CBF response to both adenosine (1.73±0.48 vs. 2.58±0.54; pfunction and on coronary microvascular dilator function. Copyright © 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

  3. Acute effects of coffee on skin blood flow and microvascular function.

    Science.gov (United States)

    Tesselaar, Erik; Nezirevic Dernroth, Dzeneta; Farnebo, Simon

    2017-11-01

    Studies on the acute effects of coffee on the microcirculation have shown contradicting results. This study aimed to investigate if intake of caffeine-containing coffee changes blood flow and microvascular reactivity in the skin. We measured acute changes in cutaneous vascular conductance (CVC) in the forearm and the tip of the finger, the microvascular response to transdermal iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) and post-occlusive reactive hyperemia (PORH) in the skin, after intake of caffeinated or decaffeinated coffee. Vasodilatation during iontophoresis of ACh was significantly stronger after intake of caffeinated coffee compared to after intake of decaffeinated coffee (1.26±0.20PU/mmHg vs. 1.13±0.38PU/mmHg, Pcoffee. After intake of caffeinated coffee, a more pronounced decrease in CVC in the fingertip was observed compared to after intake of decaffeinated coffee (-1.36PU/mmHg vs. -0.52PU/mmHg, P=0.002). Caffeine, as ingested by drinking caffeinated coffee acutely improves endothelium-dependent microvascular responses in the forearm skin, while endothelium-independent responses to PORH and SNP iontophoresis are not affected. Blood flow in the fingertip decreases markedly during the first hour after drinking caffeinated coffee compared to decaffeinated coffee. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Modeling of pulsatile flow-dependent nitric oxide regulation in a realistic microvascular network.

    Science.gov (United States)

    Wang, Ruofan; Pan, Qing; Kuebler, Wolfgang M; Li, John K-J; Pries, Axel R; Ning, Gangmin

    2017-09-01

    Hemodynamic pulsatility has been reported to regulate microcirculatory function. To quantitatively assess the impact of flow pulsatility on the microvasculature, a mathematical model was first developed to simulate the regulation of NO production by pulsatile flow in the microcirculation. Shear stress and pressure pulsatility were selected as regulators of endothelial NO production and NO-dependent vessel dilation as feedback to control microvascular hemodynamics. The model was then applied to a real microvascular network of the rat mesentery consisting of 546 microvessels. As compared to steady flow conditions, pulsatile flow increased the average NO concentration in arterioles from 256.8±93.1nM to 274.8±101.1nM (Pflow as compared to steady flow conditions. Network perfusion and flow heterogeneity were improved under pulsatile flow conditions, and vasodilation within the network was more sensitive to heart rate changes than pulse pressure amplitude. The proposed model simulates the role of flow pulsatility in the regulation of a complex microvascular network in terms of NO concentration and hemodynamics under varied physiological conditions. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Phase coherence of 0.1 Hz microvascular tone oscillations during the local heating

    Science.gov (United States)

    Mizeva, I. A.

    2017-06-01

    The origin of the mechanisms of blood flow oscillations at low frequencies is discussed. It is known that even isolated arteriole demonstrates oscillations with the frequency close to 0.1 Hz, which is caused by the synchronous activity of myocyte cells. On the other hand, oscillations with close frequency are found in the heart rate, which are associated with quite different mechanism. The main purpose of this work is to study phase coherence of the blood flow oscillations in the peripheral vessels under basal and perturbed conditions. Local heating which locally influences the microvascular tone, as one of currently elucidated in sufficient detail physiological test, was chosen. During such provocation blood flow though the small vessels significantly increases because of vasodilation induced by the local synthesis of nitric oxide. In the first part of the paper microvascular response to the local test is quantified in healthy and pathological conditions of diabetes mellitus type 1. It is obtained that regardless of the pathology, subjects with high basal perfusion had lower reserve for vasodilation, which can be caused by the low elasticity of microvascular structure. Further synchronization of pulsations of the heated and undisturbed skin was evaluated on the base of wavelet phase coherency analysis. Being highly synchronised in basal conditions 0.1 Hz pulsations became more independent during heating, especially during NO-mediated vasodilation.

  6. Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke

    Science.gov (United States)

    Zirak, Peyman; Delgado-Mederos, Raquel; Dinia, Lavinia; Carrera, David; Martí-Fàbregas, Joan; Durduran, Turgut

    2014-01-01

    The ultimate goal of therapeutic strategies for ischemic stroke is to reestablish the blood flow to the ischemic region of the brain. However, currently, the local cerebral hemodynamics (microvascular) is almost entirely inaccessible for stroke clinicians at the patient bed-side, and the recanalization of the major cerebral arteries (macrovascular) is the only available measure to evaluate the therapy, which does not always reflect the local conditions. Here we report the case of an ischemic stroke patient whose microvascular cerebral blood flow and oxygenation were monitored by a compact hybrid diffuse optical monitor during thrombolytic therapy. This monitor combined diffuse correlation spectroscopy and near-infrared spectroscopy. The reperfusion assessed by hybrid diffuse optics temporally correlated with the recanalization of the middle cerebral artery (assessed by transcranial-Doppler) and was in agreement with the patient outcome. This study suggests that upon further investigation, diffuse optics might have a potential for bed-side acute stroke monitoring and therapy guidance by providing hemodynamics information at the microvascular level.

  7. COAGULATION PROFILE IN DIABETES MELLITUS AND ITS ASSOCIATION WITH MICROVASCULAR COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Uma Shankar Mishra

    2017-12-01

    Full Text Available BACKGROUND This study intends to assess the changes in the simple routine coagulation parameters in diabetes mellitus and to investigate whether any relationship exists among changes in these coagulation parameters and development of microvascular complication in diabetes mellitus. MATERIALS AND METHODS Period of study was from 2010-2012. It was done in M.K.C.G. Medical College with the approval from Berhampur University. It is a case control study. 50 diabetic patients and 50 age and sex matched non-diabetic patients were randomly selected. Simple coagulation parameters like Activated Partial Thromboplastin Time (aPTT, Prothrombin Time (PT, serum fibrinogen, platelet count and Plasminogen Activator Inhibitor-1 (PAI-1 were measured. Statistical study was done using unpaired t-test and analysis and calculations were done using GraphPad software. RESULTS Serum fibrinogen was found to be increased in diabetic patients when compared to non-diabetic patients (mean 278 ± 26.9 v/s 232.52 ± 16.5, P value - 0.009, significant. PAI-1 levels was found to be higher among the diabetics when compared to nondiabetics (47.64 ± 8.82 v/s 31.06 ± 7.12, the two-tailed P value is <0.0001, considered extremely significant. Platelet count through within normal limits. It was found to be decreased in diabetic patient when compared to non-diabetic (2.25 ± 0.18 v/s 2.33 ± 0.03, P value - 0.022. Prothrombin Time (PT (13.15 ± 0.52 v/s 13.04 ± 0.49, P value - 0.28 and PTT (33.04 ± 1.31 v/s 32.99 ± 1.29, P value 0.85, found to be statistically insignificant. Among 50 diabetic patients, 24 had neuropathy, 20 had nephropathy, 10 had retinopathy and 21 had none of these complications. On comparing diabetic patients with microvascular complications and without microvascular complications, significant age difference was observed (59.55 ± 5.06 v/s 51.00 ± 3.31, P=0.003. This probably was a reflection of increase in microvascular complications with increasing duration

  8. Transmural Variation and Anisotropy of Microvascular Flow Conductivity in the Rat Myocardium

    KAUST Repository

    Smith, Amy F.

    2014-05-28

    Transmural variations in the relationship between structural and fluid transport properties of myocardial capillary networks are determined via continuum modeling approaches using recent three-dimensional (3D) data on the microvascular structure. Specifically, the permeability tensor, which quantifies the inverse of the blood flow resistivity of the capillary network, is computed by volume-averaging flow solutions in synthetic networks with geometrical and topological properties derived from an anatomically-detailed microvascular data set extracted from the rat myocardium. Results show that the permeability is approximately ten times higher in the principal direction of capillary alignment (the "longitudinal" direction) than perpendicular to this direction, reflecting the strong anisotropy of the microvascular network. Additionally, a 30% increase in capillary diameter from subepicardium to subendocardium is shown to translate to a 130% transmural rise in permeability in the longitudinal capillary direction. This result supports the hypothesis that perfusion is preferentially facilitated during diastole in the subendocardial microvasculature to compensate for the severely-reduced systolic perfusion in the subendocardium.

  9. Quantitative evaluation of capillaroscopic microvascular changes in patients with established coronary heart disease.

    Science.gov (United States)

    Sanchez-Garcia, M Esther; Ramirez-Lara, Irene; Gomez-Delgado, Francisco; Yubero-Serrano, Elena M; Leon-Acuña, Ana; Marin, Carmen; Alcala-Diaz, Juan F; Camargo, Antonio; Lopez-Moreno, Javier; Perez-Martinez, Pablo; Tinahones, Francisco José; Ordovas, Jose M; Caballero, Javier; Blanco-Molina, Angeles; Lopez-Miranda, Jose; Delgado-Lista, Javier

    2018-02-23

    Microcirculation disturbances have been associated to most of the cardiovascular risk factors as well as to multiple inflammatory diseases. However, whether these abnormalities are specifically augmented in patients with coronary heart disease is still unknown. We aimed to evaluate if there is a relationship between the presence of coronary heart disease and the existence of functional and structural capillary abnormalities evaluated in the cutaneous microcirculation by videocapillaroscopy. Two matched samples of 30 participants with and without coronary heart disease but with similar clinical and anthropometric characteristics were evaluated by videocapillaroscopy at the dorsal skin of the third finger of the non-dominant hand. We calculated basal capillary density as well as capillary density after a period of arterial and venous occlusion in order to evaluate functionality and maximum capillary density. We also measured capillary recruitment. Microvascular capillary density at rest was significantly lower in patients suffering from coronary heart disease than in controls. This fact was also found after dynamic tests (arterial and venous occlusion), suggesting functional impairments. Capillary recruitment of the samples was not different in our sample. In our study, patients with coronary heart disease exhibit functional and structural microvascular disturbances. Although this is a very preliminary study, these findings open the door for further studying the microvascular functionality in coronary patients and how it relates to the response to treatment and/or the prognosis of the disease. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  10. Bone marrow blood vessel ossification and "microvascular dead space" in rat and human long bone.

    Science.gov (United States)

    Prisby, Rhonda D

    2014-07-01

    Severe calcification of the bone microvascular network was observed in rats, whereby the bone marrow blood vessels appeared ossified. This study sought to characterize the magnitude of ossification in relation to patent blood vessels and adipocyte content in femoral diaphyses. Additionally, this study confirmed the presence of ossified vessels in patients with arteriosclerotic vascular disease and peripheral vascular disease and cellulitis. Young (4-6 month; n=8) and old (22-24 month; n=8) male Fischer-344 rats were perfused with barium sulfate to visualize patent bone marrow blood vessels. Femoral shafts were processed for bone histomorphometry to quantify ossified (Goldner's Trichrome) and calcified (Alizarin Red) vessels. Adipocyte content was also determined. Additional femora (n=5/age group) were scanned via μCT to quantify microvascular ossification. Bone marrow blood vessels from the rats and the human patients were also isolated and examined via microscopy. Ossified vessels (rats and humans) had osteocyte lacunae on the vessel surfaces and "normal" vessels were transitioning into bone. The volume of ossified vessels was 4800% higher (pnecrosis. Progression of bone microvascular ossification may provide the common link associated with age-related changes in bone and bone marrow. The clinical implications may be evident in the difficulties treating bone disease in the elderly. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Clinical reference value of retinal microvascular changes in patients with cerebral microbleeds

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    Ji-Yuan Guo

    2014-12-01

    Full Text Available AIM: To study clinical reference value of retinal microvascular changes in patients with cerebral microbleeds(CMBsand discuss its clinical significance. METHODS:From January 2012 to December 2013, 125 hospitalized patients were collected, including 81 cases were male, 44 cases were female, mean age 76.3±11.2 years old. For all patients, functions of liver and kidney, blood-lipoids, blood sugar and blood biochemical examination were tested, and fundus photography and cerebral MR was done. According to the fundus camera eyes, retinal arteriolar equivalent(RAE, retinal venular equivalent(RVE, retinal vein diameter ratio(AVRand arteriovenous crossing sign(AVNwere identified, CMBs were classified with cerebral MRI. All the data were processed by SPSS statistical software. RESULTS: The central retinal arteriolar equivalent(CRAE, central retinal venular equivalent(CRVEand AVR values in the eyes were found no statistical difference(PPCOCLUSION: The results show that retinal microvascular changes, especially small retinal vein arteriovenous cross width, and arteriovenous crossing phenomenon, in which CMBs will happen more likely. After sex, age, hypertension and hyperglycemia in patients with traditional cardiovascular risk factors being ruled out, the retinal microvascular changes are still relatively factors of CMB's occurrence.

  12. The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction.

    Science.gov (United States)

    Buise, Marc P; Ince, Can; Tilanus, Hugo W; Klein, Jan; Gommers, Diederik; van Bommel, Jasper

    2005-04-01

    Esophagectomy followed by gastric tube reconstruction is the surgical treatment of choice for patients with esophageal cancer. Complications of the cervical anastomosis are associated with impaired microvascular blood flow (MBF) and ischemia in the gastric fundus. The aim of the present study was to differentiate whether the decrease in MBF is a result of arterial insufficiency or of venous congestion. To do this we assessed MBF, microvascular hemoglobin oxygen saturation (muHbSo(2)), and microvascular hemoglobin concentration (muHbcon) simultaneously during different stages of gastric tube reconstruction. In 14 patients, MBF was determined with laser Doppler flowmetry, and muHbSo(2) and muHbcon were determined with reflectance spectro- photometry. After completion of the anastomosis, nitroglycerin was applied at the fundus. Although MBF did not change significantly in the pylorus, MBF decreased progressively during surgery in the fundus from 210 +/- 18 Arbitrary Units at baseline (normal stomach) to 52 +/- 9 Arbitrary Units after completion of reconstruction (mean +/- sem; P tube reconstruction but that muHbSo(2) and muHbcon do not. This decrease might be the result of venous congestion, which can partly be counteracted by application of nitroglycerin.

  13. Empoderamiento en mujeres mexicanas: Experiencias de mujeres líderes de México

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    Julita Elemí Hernández Sánchez

    2015-06-01

    Full Text Available En artículo analiza el término de empoderamiento, y las experiencias en la vida de mujeres líderes políticas mexicanas, con el fin de determinar cuáles de estas experiencias influyeron  en el  proceso de empoderamiento. Se analiza como las mujeres mismas vivieron ese proceso y que sucesos fueron comunes a ellas, en especial desde los ejes de análisis de educación, crianza, ambiente familiar, religión, entre otras. De acuerdo a lo esperado, se encontró que las mujeres entrevistadas, a pesar de ser de diversos orígenes comparten experiencias que las ayudaron o bien dificultaron su proceso de empoderamiento.

  14. The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies.

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    Reinhold J Medina

    Full Text Available BACKGROUND: Current guidelines encourage the use of statins to reduce the risk of cardiovascular disease in diabetic patients; however the impact of these drugs on diabetic retinopathy is not well defined. Moreover, pleiotropic effects of statins on the highly specialised retinal microvascular endothelium remain largely unknown. The objective of this study was to investigate the effects of clinically relevant concentrations of simvastatin on retinal endothelium in vitro and in vivo. METHODS AND FINDINGS: Retinal microvascular endothelial cells (RMECs were treated with 0.01-10 microM simvastatin and a biphasic dose-related response was observed. Low concentrations enhanced microvascular repair with 0.1 microM simvastatin significantly increasing proliferation (p<0.05, and 0.01 microM simvastatin significantly promoting migration (p<0.05, sprouting (p<0.001, and tubulogenesis (p<0.001. High concentration of simvastatin (10 microM had the opposite effect, significantly inhibiting proliferation (p<0.01, migration (p<0.01, sprouting (p<0.001, and tubulogenesis (p<0.05. Furthermore, simvastatin concentrations higher than 1 microM induced cell death. The mouse model of oxygen-induced retinopathy was used to investigate the possible effects of simvastatin treatment on ischaemic retinopathy. Low dose simvastatin (0.2 mg/Kg promoted retinal microvascular repair in response to ischaemia by promoting intra-retinal re-vascularisation (p<0.01. By contrast, high dose simvastatin(20 mg/Kg significantly prevented re-vascularisation (p<0.01 and concomitantly increased pathological neovascularisation (p<0.01. We also demonstrated that the pro-vascular repair mechanism of simvastatin involves VEGF stimulation, Akt phosphorylation, and nitric oxide production; and the anti-vascular repair mechanism is driven by marked intracellular cholesterol depletion and related disorganisation of key intracellular structures. CONCLUSIONS: A beneficial effect of low

  15. Mi experiencia en COMISEDH - Comisión de Derechos Humanos

    OpenAIRE

    Leal Lillo, María

    2017-01-01

    Treball final de Màster Universitari en Cooperació al Desenvolupament (Pla de 2015). Codi: SRP531. Curs acadèmic 2016-2017 En este trabajo se presenta la experiencia de prácticas externas del Máster en Cooperación al Desarrollo de la Universidad Jaume I, llevada a cabo en COMISEDH-Comisión de Derechos Humanos, una asociación civil sin ánimo de lucro con 38 años de experiencia en la lucha por los derechos humanos en Perú. A lo largo de los distintos apartados se presenta la entidad y el con...

  16. Diseño de una experiencia de tiro parabólico para Bachillerato

    OpenAIRE

    Peña Maniega, Víctor

    2014-01-01

    En este trabajo fin de máster se presenta el diseño de una experiencia de laboratorio de tiro parabólico para alumnos de Bachillerato. El objetivo general es que dicha experiencia sea novedosa, motivante y un ejemplo práctico de la aplicación de las diversas fases del método científico. Para ello, se utiliza un lanzador casero de proyectiles de aire comprimido, y la grabación en video digital como herramienta de trabajo y análisis. También se presentan opciones de cómo realizar...

  17. Papel de la experiencia en la aceptación vs. rechazo del paciente con esquizofrenia

    OpenAIRE

    Carmen Senra-Rivera; Alessandra de Arriba-Rossetto; Gloria Seoane-Pesqueira

    2008-01-01

    En esta investigación se analiza la influencia que pueden tener distintos tipos y grados de experiencia con la enfermedad mental en la aceptación vs. rechazo del paciente con esquizofrenia. Participaron en el estudio 236 estudiantes universitarios que cumplimentaron una escala de distancia social relacionada con una viñeta en la que se describe un episodio psicótico de un paciente (hombre o mujer) con esquizofrenia y una escala que evalúa distintos tipos y grados de experiencia co...

  18. EXAMEN DE POST-EFECTO PARA EXPERIENCIAS ANÓMALO/ PARANORMALES CON UN ABORDAJE HUMANISTA

    OpenAIRE

    PARRA, ALEJANDRO; CORBETTA, JUAN MANUEL

    2014-01-01

    Se presentan los resultados de una investigación que tuvo como objetivos: explorar la utilidad de la terapia grupal para hacer frente a los efectos de las experiencias paranormales y explorar cómo la terapia humanista produce cambios positivos hacia las experiencias anómalo/paranormales. Se les pidió a la muestra (N= 20, rango 22-71 años, M= 45,65, DT= 12,52), 65 % mujeres y 35 % varones, responder un cuestionario autoadministrado de siete preguntas antes y al finalizar su participación en un...

  19. Examen de post-efecto para experiencias anómalo/ paranormales con un abordaje humanista

    OpenAIRE

    Alejandro Parra; Juan Manuel Corbetta

    2014-01-01

    Se presentan los resultados de una investigación que tuvo como objetivos: explorar la utilidad de la terapia grupal para hacer frente a los efectos de las experiencias paranormales y explorar cómo la terapia humanista produce cambios positivos hacia las experiencias anómalo/paranormales. Se les pidió a la muestra (N= 20, rango 22-71 años, M= 45,65, DT= 12,52), 65 % mujeres y 35 % varones, responder un cuestionario autoadministrado de siete preguntas antes y al finalizar su participación en un...

  20. Negociación y diplomacia en las fronteras del Chaco: Nuestra Señora de la Concepción de abipones * Negociação e diplomacia nas fronteiras do Chaco: Nuestra Señora de la Concepción de abipones

    Directory of Open Access Journals (Sweden)

    CARINA PAULA LUCAIOLI

    2014-09-01

    Full Text Available Resumen: A lo largo de estas páginas nos hemos propuesto reconstruir y analizar los procesos históricos que desembocaron en la fundación de la reducción de Nuestra Señora de la Concepción de abipones, fundada en 1749 en los espacios de frontera del Chaco austral. Asimismo, presentamos la trascripción y análisis de las Capitulaciones celebradas como corolario de las negociaciones entabladas entre indígenas e hispanocriollos, con la intención de resaltar los aspectos diplomáticos inherentes a las paces que hicieron posible la fundación de la reducción.Palabras clave: Diplomacia – Reducciones – Tratados de Paz – Acuerdos Coloniales. Resumo: Ao longo destas páginas, propusemos reconstruir e analisar os processos históricos que conduziram à fundação da redução de Nuestra Señora de la Concepción de abipones, fundada em 1749 nas áreas de fronteira do sul do Chaco. Apresentamos também a transcrição e análise das capitulações realizadas como corolário das negociações entre indígenas e hispanocriollos, com a intenção de destacar os aspectos diplomáticos que tornaram possível a fundação da redução.Palavras-chave: Diplomacia – Reduções – Tratado de Paz – Acordos Coloniais.

  1. EXPERIENCIA DEL ENTRENAMIENTO MUSICAL EN UNA UNIVERSIDAD PARTICULAR DE LIMA

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    Daniel Ravelo Franco

    2012-12-01

    Full Text Available RESUMEN: El objetivo de la Revolución del Entrenamiento Musical es aprovechar las modernas herramientas tecnológicas para la educación, aplicándolas al entrenamiento auditivo, dentro de un programa de formación musical profesional. En este trabajo, se presentará la experiencia de transformación del curso presencial de Nivelación en Lectura y Entrenamiento Auditivo, de un pregrado universitario de Música, a la modalidad b-learning. La modalidad b-learning de este curso se estableció sobre un Aula Virtual en una plataforma Moodle. El trabajo en línea, dentro de esta Aula Virtual, incluyó foros de comunicación, foros académicos, recursos autoinstructivos de entrenamiento auditivo y tareas académicas. La estrategia del trabajo online del curso consideró varios aspectos: 1 Estructura del Aula Virtual; 2 Comunicación dentro del Aula Virtual; 3 Administración del Aula Virtual; 4 Creación y organización de contenidos; 5 Planteamiento de una metodología de estudio en línea; 6 Diseño y puesta en marcha de las actividades en línea; 7 Calificación de las actividades realizadas en línea; 8 Evaluación de todo el proceso. Los resultados obligaron a replantear los contenidos del mismo curso en los niveles siguientes debido a los importantes avances alcanzados. ABSTRACT: The aim of the Musical Training Revolution is to take advantage of the modern educational technology tools, to apply them to the auditory training in a professional music training program. In this paper, the experience of transforming the classroom course in Leveling in Reading and Ear Training is presented, from a university undergraduate Music, to a b-learning mode. b-learning mode of this course is set on a virtual classroom on the Moodle platform. Online work within this virtual classroom included communication forums, academic forums, ear training self-instructive resources and academic tasks. The working strategy of on-line courses considered several aspects: 1

  2. Aprendizaje con robótica, algunas experiencias

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    Pedro Antonio López Ramírez

    2013-01-01

    Full Text Available Este artículo presenta el análisis de experiencias, revisadas en diversos artículos, acerca de la implementación de la robótica en la educación, con el fin de obtener referentes pertinentes para la construcción de una propuesta para el aprendizaje de la robótica en la educación básica secundaria y media. Se consideran dos ámbitos de aplicación de la robótica en la educación: el primero es el aprendizaje de la robótica mediante la conceptualización de cada uno de los subsistemas de un robot para luego realizar la construcción de robots con diferentes propósitos, en este ámbito el objetivo es desarrollar las competencias, en los estudiantes, para el diseño y construcción de tecnofactos robóticos, mediante un proceso de construcción del conocimiento necesario para hacerlo; el segundo ámbito de aplicación es la utilización de la robótica como medio que motiva y da sentido a la construcción de conocimiento en diversas áreas, promoviendo habilidades y competencias en los estudiantes. Además, el aprendizaje de la robótica y el aprendizaje con robótica pueden ser mediados por la informática, la cual aporta tecnologías y herramientas software como los lenguajes de modelado matemático y simulación, tutoriales multimediales, laboratorios virtuales y remotos, entre otros. Así, este artículo se propone destacar cómo la robótica en el aula de clase permite, por una parte, el enriquecer estrategias de aprendizaje como apoyo a la formación integral de los estudiantes, y por otra, es un campo que presenta una demanda creciente en la atención de docentes e investigadores, así como en los estímulos para su investigación, desarrollo y divulgación de parte del estado.

  3. La experiencia del Centro Centroamericano de Población

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    Carmen Marín

    2006-01-01

    Full Text Available Introducción.- Las NTIC abren nuevas posibilidades para la educación. Aprender en entornos mediados por NTIC supone flexibilidad en espacio y tiempo e interacción entre los participantes para el aprendizaje significativo. Las universidades al implementar ofertas formativas de carácter virtual deben reconsiderar sus modelos de enseñanza y de aprendizaje e iniciar procesos de análisis y revisión de las experiencias realizadas. El presente artículo pretende sistematizar el accionar del proyecto CapDis del Centro Centroamericano de Población (CCP al introducir el uso de las nuevas tecnologías de información y comunicación en la educación superior en la Universidad de Costa Rica (UCR. Métodos.- Se basa en un estudio de caso que aplica el método cualitativo mediante revisión documental y registro de eventos. Resultados.- En CapDis se identifican las siguientes etapas: I. Páginas web vinculadas; II. Páginas web integradas y III. Learning Management System. En las primeras dos etapas se dio soporte a los profesores y se asumió la mayor parte de las tareas de implementación y mantenimiento. Cuando se incorporó moodle.org, se facilitó la participación de más profesores quienes asumieron un rol más activo en CapDis. A marzo 2005, la comparación de metas y resultados evidencia que fueron superados los resultados esperados. Discusión.- El presente artículo se constituye en un insumo útil en la identificación de las dificultades, alcances y limitaciones de la incorporación de las NTIC en la docencia en educación superior en la Universidad de Costa Rica. Las etapas identificadas en CapDis han sido descritas en términos del alcance de los recursos NTIC puestos en práctica. Más allá de los aspectos tecnológicos y administrativos descritos, el proceso seguido por CapDis logró enriquecer la interacción de una modalidad asíncrona (diferida a una síncrona (inmediata, lo que abre la oportunidad de contribuir a una mejor

  4. Conflicting interactions of apolipoprotein A and high density lipoprotein cholesterol with microvascular complications of type 2 diabetes.

    Science.gov (United States)

    Aryan, Zahra; Afarideh, Mohsen; Ghajar, Alireza; Esteghamati, Sadaf; Esteghamati, Alireza; Nakhjavani, Manouchehr

    2017-11-01

    This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D). A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. A total of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D were included. The associations and interactions of a panel of serum lipid biomarkers with the microvascular complications of T2D were investigated. Serum triglyceride had the strongest association with microvascular complications of T2D (crude model: β=0.632, P value=0.045). Each standard deviation increment in serum TG was associated with 3.7 times increased frequency of microvascular complications. Despite high density lipoprotein cholesterol (HDL-C), serum apolipoprotein A1 (Apo A1) was positively associated with the presence of diabetic neuropathy. Each standard deviation increment in serum ApoA1 was associated with increased frequency of diabetic neuropathy (OR, 1.2, 95% CI, (1.1-1.3), P value=0.006). The frequency of diabetic neuropathy was higher in 2nd and 3rd quartiles of serum Lp(a) compared to diabetic patients in the first quartile (OR, 5.52, 95% (1.17-25.8), P value=0.047). ApoA1 but not HDL-C is straightly associated with diabetic neuropathy. Even Slight rise in serum Lp(a) is associated with increased frequency of diabetic retinopathLipid variables could serve as specific predictors of vascular complications in diabetes. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Impact of an endothelial progenitor cell capturing stent on coronary microvascular function: comparison with drug-eluting stents.

    Science.gov (United States)

    Choi, Woong Gil; Kim, Soo Hyun; Yoon, Hyung Seok; Lee, Eun Joo; Kim, Dong Woon

    2015-01-01

    Although drug-eluting stents (DESs) effectively reduce restenosis following percutaneous coronary intervention (PCI), they also delay re-endothelialization and impair microvascular function, resulting in adverse clinical outcomes. Endothelial progenitor cell (EPC) capturing stents, by providing a functional endothelial layer on the stent, have beneficial effects on microvascular function. However, data on coronary microvascular function in patients with EPC stents versus DESs are lacking. Seventy-four patients who previously underwent PCI were enrolled in this study. Microvascular function was evaluated 6 months after PCI based on the index of microvascular resistance (IMR) and the coronary flow reserve (CFR). IMR was calculated as the ratio of the mean distal coronary pressure at maximal hyperemia to the inverse of the hyperemic mean transit time (hTmn). The CFR was calculated by dividing the hTmn by the baseline mean transit time. Twenty-one patients (age, 67.2 ± 9.6 years; male:female, 15:6) with an EPC stent and 53 patients (age, 61.5 ± 14.7 years; male:female, 40:13) with second-generation DESs were included in the study. There were no significant differences in the baseline clinical and angiographic characteristics of the two groups. Angiography performed 6 months postoperatively did not show significant differences in their CFR values. However, patients with the EPC stent had a significantly lower IMR than patients with second-generation DESs (median, 25.5 [interquartile range, 12.85 to 28.18] vs. 29.0 [interquartile range, 15.42 to 39.23]; p = 0.043). Microvascular dysfunction was significantly improved after 6 months in patients with EPC stents compared to those with DESs. The complete re-endothelialization achieved with the EPC stent may provide clinical benefits over DESs, especially in patients with microvascular dysfunction.

  6. Favoreciendo el acceso a la web: experiencias con usuarios mayores de la región patagónica

    Directory of Open Access Journals (Sweden)

    Diego Vilte

    2014-09-01

    Full Text Available En esta nueva era donde las TICs y la Web evolucionan rápidamente es de vital importancia que estos recursos puedan ser utilizados por todos los usuarios y que no existan barreras que dificulten trabajar con ellos. La accesibilidad y usabilidad, entre otros atributos de calidad, son propiedades que deben estar presentes en estas tecnologías para que puedan ser accedidas con éxito por todos los ciudadanos. Pero, la diversidad humana propone un gran variedad de usuarios Web con diferentes características y problemáticas. Por ejemplo, usuarios con algún tipo de discapacidad (problemas visuales, de motricidad y cognitivos; usuarios comprendidos en diferentes rangos de edades (adultos, adultos mayores, jóvenes y niños, usuarios pertenecientes a diferentes culturas (costumbres e idiomas, etc. También es importante considerar el hecho de que nadie está exento a lo largo de su vida de sufrir algún tipo de discapacidad permanente (o temporal que dificulte el acceso e interación con estas tecnologías y la Web.Numerosos han sido los esfuerzos de los grupos de investigación para contribuir con propuestas a la Usabilidad de la Web. También, desde 1999, año en que se presentan las primeras recomendaciones sobre Accesibilidad Web del consorcio W3C, diferentes organizaciones han propuesto estándares y guías para contribuir a una Web más accesible. Todos estas propuestas y documentos se pueden aplicar para concebir y desarrollar sitios Web nuevos, cómo así también para revisar y mejorar la Accesibilidad de los sitios Web existentes. Si embargo, aportar soluciones para ofrecer sitios Web más accesibles a los diferentes perfiles de usuario, no es un problema trivial.En este trabajo, presentamos dos experiencias con usuarios adultos mayores, para determinar y proponer mejoras que se ajusten a las necesidades de este importante y creciente grupo de usuarios Web. Nuestras propuestas surgen del trabajo conjunto entre los docentes/ investigadores

  7. Histerosonografía experiencia en el Hospital Universitario de Santander Hysterosonography experience in University Hospital of Santander

    Directory of Open Access Journals (Sweden)

    Janer Sepúlveda Agudelo

    2010-12-01

    Full Text Available Introducción: La histerosonografía consiste en la evaluación por ultrasonido de la cavidad uterina después de la insuflación de solución salina. La indicación más común de la histerosonografía es la hemorragia uterina anormal. Objetivo: Los objetivos del presente trabajo son describir los hallazgos de la histerosonografía durante el periodo estudiado en el Hospital Universitario de Santander e incentivar el uso de la histerosonografía en nuestro medio, mediante la enseñanza de la técnica a los nuevos profesionales de ginecología. Materiales y métodos: Se realizó un estudio de serie de casos con pacientes programadas para histerosonografía en el Hospital Universitario de Santander entre Febrero de 2007 y Junio de 2008, a quienes se les evaluó la cavidad uterina mediante histerosonografía, presentando una modificación a la técnica. Las variables a medir son la edad, indicación de histerosonografía, hallazgos intracavitarios, efectos secundarios. Resultados: Las indicaciones de histerosonografía fueron: Hemorragia uterina anormal 43,3%, miomatosis uterina 21,6%, lesión endometrial tipo pólipo 27,0%, infertilidad 5,4% y anomalías müllerianas 2,7%. Los hallazgos intracavitarios más comunes: Histerosonografía Normal 51,4%, pólipo endometrial 32,4% y mioma submucoso 16,2%. Se presentó como efectos secundarios dolor pélvico, episodio de lipotimia y sangrado genital moderado sin compromiso hemodinámico. Conclusión: La histerosonografía es un procedimiento seguro que permite una evaluación de la cavidad uterina, sin efectos secundarios importantes como lo demuestra nuestra experiencia. La modificación a la técnica puede evitar la incomodidad de la paciente, al realizar en una sola ocasión la introducción del transductor transvaginal, pero requiere de estudios aleatorizados controlados para confirmar esta aseveración. Salud UIS 2010; 42: 256-260Introduction: Sonohysterography is an ultrasound evaluation of the

  8. Estrés y desempeño laboral en los docentes del nivel secundario de la Institución Educativa “Nuestra Señora del Carmen” Huaral-2014

    OpenAIRE

    Flores Bazalar, Román Rafael; Gerónimo Santiago, Elizabeth Gladys

    2015-01-01

    El presente trabajo de investigación tuvo como problema general: ¿Cuál es la relación que existe entre Estrés y Desempeño Laboral en los docentes del nivel Secundario de la Institución Educativa “Nuestra Señora del Carmen” Huaral- 2014? y el objetivo general fue: Determinar la relación que existe entre Estrés y el Desempeño Laboral en los docentes del nivel Secundario de la Institución Educativa “Nuestra Señora del Carmen” Huaral-2014. El estudio de esta investigación es de ...

  9. Visão de progresso em José Martí e as raízes ideológicas de Nuestra América

    OpenAIRE

    Barbosa dos Santos, Fabio Luis

    2013-01-01

    Este artículo se enfoca em las raícesideológicas de la propuesta de José Martí(1853-1895) sobre un patrón alternativode modernidad que sustenta su proyectoNuestra América. La visión de progreso queencuadra los ideales humanísticos es resultadode la conjunción de valorar la autoctoníacomo criterio de evolución histórica y desu noción del hombre natural como paradigmade realización humana. Desde esta perspectiva,la realización de Nuestra América no es soloentendida como una estrategia geopolíti...

  10. Data set characterizing the systemic alterations of microvascular reactivity and capillary density, in patients presenting with infective endocarditis.

    Science.gov (United States)

    Tibirica, Eduardo; Barcelos, Amanda; Lamas, Cristiane

    2018-06-01

    This article represents data associated with a prior publication from our research group, under the title: Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy [1]. Patients with definite infective endocarditis, under stable clinical conditions, were prospectively included. The clinical and laboratory features are presented for each of them in raw form. Microvascular reactivity was evaluated using a laser speckle contrast imaging (LSCI) system with a laser wavelength of 785 nm. LSCI was used in combination with the iontophoresis of acetylcholine (ACh) or sodium nitroprusside (SNP) for the noninvasive, continuous measurement of cutaneous microvascular perfusion changes in arbitrary perfusion units (APU). The images were analyzed using the manufacturer's software. One skin site on the ventral surface of the forearm was chosen for the experiment. Microvascular reactivity was also evaluated using post-occlusive reactive hyperemia, whereby arterial occlusion was achieved with supra-systolic pressure (50 mmHg above the systolic arterial pressure) using a sphygmomanometer for three minutes. Following the release of pressure, maximum flux was measured. Data on cutaneous microvascular density were obtained using intravital video-capillaroscopy. The data obtained may be helpful by showing the usefulness of laser-based noninvasive techniques in systemic infectious diseases other than sepsis, in different clinical settings and countries.

  11. Experiencias formativas de jóvenes de la Universidad Intercultural de Chiapas

    Directory of Open Access Journals (Sweden)

    Diego Rodríguez Calderón de la Barca

    2016-04-01

    Full Text Available El presente texto expone las principales experiencias formativas deestudiantes y egresados/as de la Universidad Intercultural de Chiapas,San Cristóbal de las Casas (UNICH, México, en las que está implícita laarticulación de tres instituciones fundamentales en la reproducción social:la familia, la escuela (en este caso la universidad y el trabajo. Así, elobjetivo es reflexionar sobre las experiencias formativas que van marcandoa las y los jóvenes antes, durante y después de que ingresany egresan de la universidad. Son experiencias que están relacionadascon su tránsito y estancia en la universidad, pero también a otras externasal campus universitario, y a partir de las cuales también construyensu condición juvenil (social y subjetivamente. El texto está dividido entres partes. En la primera presento sintéticamente características delcontexto y población de estudio. En la segunda, de manera muy brevemenciono la perspectiva teórica y la metodología. Y en la tercera expongolas experiencias más trascendentes de acuerdo al análisis delestudio y con base en los testimonios de los jóvenes entrevistados.

  12. Pensar la experiencia mística desde la epistemología

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    Lina Marcela Cadavid Ramírez

    2016-06-01

    Full Text Available Con la crisis del paradigma newtoniano a principios del siglo XX, vemos surgir un acercamiento entre la ciencia, la religión y el misticismo, alentado por algunos de los físicos cuánticos más destacados, asimismo, la epistemología se vio afectada y a lo largo del siglo XX se entabló una discusión en torno a la objetividad del conocimiento y la construcción socio-lingüística de la realidad. Con este trasfondo, la experiencia mística será objeto de estudio por la epistemología, que desde una perspectiva constructivista afirmará el carácter mediado de este tipo de experiencias. Sin embargo, una revisión de esta postura muestra que es necesario conceder un carácter singular a la experiencia mística, que a su vez permite una comprensión renovada de la experiencia mística.

  13. Experiencias, Sensaciones y Demandas de (Inseguridad Ciudadana. Configuraciones complejas en la Argentina reciente

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    Daniel Pedro Míguez

    2013-06-01

    Full Text Available En las últimas décadas, el problema de la inseguridad debida al incremento del delito y el posible impacto sobre la estabilidad de las democracias latinoamericanas ha sido objeto de debate recurrente. En este marco, el presente artículo analiza para el caso argentino la relación entre las experiencias y sensaciones de inseguridad, y su vinculación con las demandas de rigor punitivo. El análisis se basa en la combinación de dos aproximaciones metodológicas. Inicialmente, se toman datos estadísticos de encuestas internacionales, como Latinobarómetro. Estos son luego comparados con datos revelados mediante la observación participante en un barrio pobre de una ciudad intermedia de Argentina. La combinación de fuentes alternativas permite ver la complejidad del proceso. Contrario a lo que muchas veces se ha asumido, no existen vínculos lineales que conduzcan de experiencias y sensaciones de seguridad a demandas de rigor punitivo. La manera en que los actores sociales elaboran sus experiencias de inseguridad es fuertemente situacional y, además, poco sistemática. Hemos encontrado que no necesariamente hay procesos consistentes de ‘construcción de sentido’ que articulen las sensaciones y experiencias de inseguridad con demandas políticas.

  14. Estrategias para enriquecer la experiencia de enseñanza-aprendizaje

    OpenAIRE

    Talavera Pedrol, Núria

    2011-01-01

    Este documento tiene como objetivo aportar ideas a considerar en el diseño de programas de formación online o semipresenciales y contribuir a la generación de experiencias de aprendizaje enriquecidas y al uso eficiente de los recursos ofrecidos por la plataforma de e-learning SABENTIS.

  15. Algunas experiencias de aplicación del aprendizaje cooperativo y del aprendizaje basado en proyectos

    OpenAIRE

    García-Almiñana, Daniel; Amante García, Beatriz

    2006-01-01

    En esta comunicación se pretenden presentar algunas experiencias de aplicación del AC y ABP en distintas asignaturas impartidas en la Universidad Europea de Madrid y en la Universidad Politécnica de Catalunya, destacando los aspectos de mejora observados con respecto a la docencia convencional.

  16. El conocimiento profesional adquirido por el entrenador de balonmano: experiencias y formación

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    Sebasti\\u00E1n Feu Molina

    2012-01-01

    Full Text Available El objetivo del estudio fue conocer la procedencia del conocimiento que utilizan los entrenadores de balonmano en su ejercicio profesional. En el estudio participaron 333 entrenadores españoles, 86.8% hombres y 13.2% mujeres. Se diseñó y validó un cuestionario que permitió conocer la influencia del conocimiento profesional en su intervención como entrenador: experiencia como jugador, formación académica o experiencia como entrenador. El análisis estadístico reflejó que los factores de la escala tenían una validez y fiabilidad adecuadas (¿ > .70, acreditando a este cuestionario como una herramienta válida y fiable. Los entrenadores utilizan las tres fuentes de conocimiento (académica, experiencia como jugador y autoformación, existiendo una mayor utilización del conocimiento académico. Los entrenadores con mayor formación utilizan menos las experiencias y conocimientos adquiridos como jugador y utilizan más los conocimientos adquiridos en su vida profesional.

  17. Experiencia de intercambio docente en dos asignaturas de Inteligencia Artificial en universidades argentinas

    OpenAIRE

    Mariño, Sonia Itatí; Rambo, Alice

    2014-01-01

    En ámbitos de Educación Superior se propicia la generación de redes de intercambio y difusión de conocimientos y experiencias. Se describe una iniciativa docente desarrollada en dos asignaturas que abordan temas de Inteligencia Artificial.

  18. Experiencias y vivencias del embarazo en adolescentes explicadas desde lo social

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    VIRGINIA INÉS SOTO

    2008-12-01

    Full Text Available Describir y explicar desde lo social las experiencias y vivencias de las adolescentes embarazadas, como el contexto para una provisión de cuidado integral, individualizado y contextualizado, es necesario para la práctica de enfermería, y tratar este fenómeno como hecho social exige asimilar las realidades del mundo social a las del mundo exterior, adoptando el principio de que se ignora por completo lo que son, reconociendo que el hecho social no puede ser modificado por un simple decreto de la voluntad, sino que exige un esfuerzo laborioso, considerando la experiencia desde los ámbitos interno y externo. Presentar un marco conceptual y referencial desde lo social, interpretando la experiencia y la vivencia, permitirá a la enfermera comprender este fenómeno cuando dichas experiencias involucran o ponen en riesgo la salud de la adolescente gestante, máxime que la práctica clínica de enfermería se ha estudiado primariamente desde una perspectiva sociológica, pues comparte una importancia social destacada y un fin social, centrada en facilitar, apoyar y atender a los individuos, familias, comunidades y/o sociedades para realzar, mantener y recuperar la salud, y reducir y aliviar los efectos de la enfermedad, con el resultado explícito de promover la calidad de vida relacionada con la salud dentro de contextos ambientales inmediatos y más amplios.

  19. Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction: The Maastricht Study.

    Science.gov (United States)

    Sörensen, Ben M; Houben, Alfons J H M; Berendschot, Tos T J M; Schouten, Jan S A G; Kroon, Abraham A; van der Kallen, Carla J H; Henry, Ronald M A; Koster, Annemarie; Sep, Simone J S; Dagnelie, Pieter C; Schaper, Nicolaas C; Schram, Miranda T; Stehouwer, Coen D A

    2016-11-01

    Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease. This can be partly explained by large-artery dysfunction, which already occurs in prediabetes ("ticking clock hypothesis"). Whether a similar phenomenon also applies to microvascular dysfunction is not known. We therefore tested the hypothesis that microvascular dysfunction is already present in prediabetes and is more severe in T2DM. To do so, we investigated the associations of prediabetes, T2DM, and measures of hyperglycemia with microvascular function measured as flicker light-induced retinal arteriolar dilation and heat-induced skin hyperemia. In the Maastricht Study, a T2DM-enriched population-based cohort study (n=2213, 51% men, aged [mean±standard deviation] 59.7±8.2 years), we determined flicker light-induced retinal arteriolar %-dilation (Dynamic Vessel Analyzer), heat-induced skin %-hyperemia (laser-Doppler flowmetry), and glucose metabolism status (oral glucose tolerance test; normal glucose metabolism [n=1269], prediabetes [n=335], or T2DM [n=609]). Differences were assessed with multivariable regression analyses adjusted for age, sex, body mass index, smoking, physical activity, systolic blood pressure, lipid profile, retinopathy, estimated glomerular filtration rate, (micro)albuminuria, the use of lipid-modifying and blood pressure-lowering medication, and prior cardiovascular disease. Retinal arteriolar %-dilation was (mean±standard deviation) 3.4±2.8 in normal glucose metabolism, 3.0±2.7 in prediabetes, and 2.3±2.6 in T2DM. Adjusted analyses showed a lower arteriolar %-dilation in prediabetes (B=-0.20, 95% confidence interval -0.56 to 0.15) with further deterioration in T2DM (B=-0.61 [-0.97 to -0.25]) versus normal glucose metabolism (P for trend=0.001). Skin %-hyperemia was (mean±standard deviation) 1235±810 in normal glucose metabolism, 1109±748 in prediabetes, and 937±683 in T2DM. Adjusted analyses showed a lower %-hyperemia in prediabetes (B=-46

  20. Reconstrucción mamaria con expansor tisular e implante: Indicaciones y experiencia en 24 casos Breast reconstruction with tissue expander: Indications and experience in 24 cases

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    C. Gutiérrez Gómez

    2012-12-01

    Full Text Available En la actualidad, la reconstrucción mamaria forma parte integral del tratamiento del cáncer de mama; la selección de la paciente es crítica para obtener resultados satisfactorios. El presente trabajo recoge nuestra experiencia en reconstrucción mamaria con expansión tisular e implantes, haciendo hincapié en la selección de las pacientes candidatas a este método reconstructivo. Revisamos las reconstrucciones mamarias realizadas en un período comprendido entre los años 1998 y 2008 por la misma cirujana, analizando factores como tipo de mastectomía, edad, tiempo de la reconstrucción (inmediata o diferida, causa de la mastectomía, tipo de expansor y prótesis utilizados, complicaciones y satisfacción de las pacientes. En todas excepto en una, la reconstrucción se realizó en dos tiempos operatorios; durante el primero se hizo la colocación del expansor tisular y en el segundo, el cambio por la prótesis mamaria definitiva. Se realizaron un total de 24 reconstrucciones mamarias en 19 pacientes en el período de 10 años revisado, 14 unilaterales y 5 bilaterales. Las complicaciones presentadas en este grupo de pacientes fueron del 16,6 %. El seguimiento de las pacientes fue de 2 a 10 años. Solamente en 1 caso de cuadrantectomía, se realizó la reconstrucción de forma diferida por antecedente de radioterapia (4,1 %. En nuestra opinión, la reconstrucción mamaria con expansor tisular e implante es un procedimiento seguro, reproducible y con bajo índice de complicaciones, sin el inconveniente añadido de ocasionar morbilidad en el a área donante.Nowadays, breast reconstruction is part of breast carcinoma treatment; patient's selection plays an important role in satisfactory results. The present paper reports our experience in breast reconstruction with tissue expander/implant and emphasizes the importance of choosing the candidates for this method of reconstruction. We review the breast reconstructions realized in a 10 year period

  1. Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms

    Science.gov (United States)

    Dongare, Shirish; Mathur, Rajani; Saxena, Rohit; Mathur, Sandeep; Agarwal, Renu; Nag, Tapas C.; Srivastava, Sushma; Kumar, Pankaj

    2016-01-01

    Purpose Diabetic retinopathy is a common microvascular complication of long-standing diabetes. Several complex interconnecting biochemical pathways are activated in response to hyperglycemia. These pathways culminate into proinflammatory and angiogenic effects that bring about structural and functional damage to the retinal vasculature. Since Zingiber officinale (ginger) is known for its anti-inflammatory and antiangiogenic properties, we investigated the effects of its extract standardized to 5% 6-gingerol, the major active constituent of ginger, in attenuating retinal microvascular changes in rats with streptozotocin-induced diabetes. Methods Diabetic rats were treated orally with the vehicle or the ginger extract (75 mg/kg/day) over a period of 24 weeks along with regular monitoring of bodyweight and blood glucose and weekly fundus photography. At the end of the 24-week treatment, the retinas were isolated for histopathological examination under a light microscope, transmission electron microscopy, and determination of the retinal tumor necrosis factor-α (TNF-α), nuclear factor-kappa B (NF-κB), and vascular endothelial growth factor (VEGF) levels. Results Oral administration of the ginger extract resulted in significant reduction of hyperglycemia, the diameter of the retinal vessels, and vascular basement membrane thickness. Improvement in the architecture of the retinal vasculature was associated with significantly reduced expression of NF-κB and reduced activity of TNF-α and VEGF in the retinal tissue in the ginger extract–treated group compared to the vehicle-treated group. Conclusions The current study showed that ginger extract containing 5% of 6-gingerol attenuates the retinal microvascular changes in rats with streptozotocin-induced diabetes through anti-inflammatory and antiangiogenic actions. Although precise molecular targets remain to be determined, 6-gingerol seems to be a potential candidate for further investigation. PMID:27293376

  2. The relationship between red blood cell deformability metrics and perfusion of an artificial microvascular network.

    Science.gov (United States)

    Sosa, Jose M; Nielsen, Nathan D; Vignes, Seth M; Chen, Tanya G; Shevkoplyas, Sergey S

    2014-01-01

    The ability of red blood cells (RBC) to undergo a wide range of deformations while traversing the microvasculature is crucial for adequate perfusion. Interpretation of RBC deformability measurements performed in vitro in the context of microvascular perfusion has been notoriously difficult. This study compares the measurements of RBC deformability performed using micropore filtration and ektacytometry with the RBC ability to perfuse an artificial microvascular network (AMVN). Human RBCs were collected from healthy consenting volunteers, leukoreduced, washed and exposed to graded concentrations (0-0.08%) of glutaraldehyde (a non-specific protein cross-linker) and diamide (a spectrin-specific protein cross-linker) to impair the deformability of RBCs. Samples comprising cells with two different levels of deformability were created by adding non-deformable RBCs (hardened by exposure to 0.08% glutaraldehyde) to the sample of normal healthy RBCs. Ektacytometry indicated a nearly linear decline in RBC deformability with increasing glutaraldehyde concentration. Micropore filtration showed a significant reduction only for concentrations of glutaraldehyde higher than 0.04%. Neither micropore filtration nor ektacytometry measurements could accurately predict the AMVN perfusion. Treatment with diamide reduced RBC deformability as indicated by ektacytometry, but had no significant effect on either micropore filtration or the AMVN perfusion. Both micropore filtration and ektacytometry showed a linear decline in effective RBC deformability with increasing fraction of non-deformable RBCs in the sample. The corresponding decline in the AMVN perfusion plateaued above 50%, reflecting the innate ability of blood flow in the microvasculature to bypass occluded capillaries. Our results suggest that in vitro measurements of RBC deformability performed using either micropore filtration or ektacytometry may not represent the ability of same RBCs to perfuse microvascular networks. Further

  3. Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction.

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    Maria Giovanna Scioli

    Full Text Available Impaired wound healing represents a high cost for health care systems. Endothelial dysfunction characterizes dermal microangiopathy and contributes to delayed wound healing and chronic ulcers. Endothelial dysfunction impairs cutaneous microvascular blood flow by inducing an imbalance between vasorelaxation and vasoconstriction as a consequence of reduced nitric oxide (NO production and the increase of oxidative stress and inflammation. Propionyl-L-carnitine (PLC is a natural derivative of carnitine that has been reported to ameliorate post-ischemic blood flow recovery.We investigated the effects of PLC in rat skin flap and cutaneous wound healing. A daily oral PLC treatment improved skin flap viability and associated with reactive oxygen species (ROS reduction, inducible nitric oxide synthase (iNOS and NO up-regulation, accelerated wound healing and increased capillary density, likely favoring dermal angiogenesis by up-regulation for iNOS, vascular endothelial growth factor (VEGF, placental growth factor (PlGF and reduction of NADPH-oxidase 4 (Nox4 expression. In serum-deprived human dermal microvascular endothelial cell cultures, PLC ameliorated endothelial dysfunction by increasing iNOS, PlGF, VEGF receptors 1 and 2 expression and NO level. In addition, PLC counteracted serum deprivation-induced impairment of mitochondrial β-oxidation, Nox4 and cellular adhesion molecule (CAM expression, ROS generation and leukocyte adhesion. Moreover, dermal microvascular endothelial cell dysfunction was prevented by Nox4 inhibition. Interestingly, inhibition of β-oxidation counteracted the beneficial effects of PLC on oxidative stress and endothelial dysfunction.PLC treatment improved rat skin flap viability, accelerated wound healing and dermal angiogenesis. The beneficial effects of PLC likely derived from improvement of mitochondrial β-oxidation and reduction of Nox4-mediated oxidative stress and endothelial dysfunction. Antioxidant therapy and

  4. Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk.

    Science.gov (United States)

    Roy, Hemant K; Gomes, Andrew; Turzhitsky, Vladimir; Goldberg, Michael J; Rogers, Jeremy; Ruderman, Sarah; Young, Kim L; Kromine, Alex; Brand, Randall E; Jameel, Mohammed; Vakil, Parmede; Hasabou, Nahla; Backman, Vadim

    2008-10-01

    We previously used a novel biomedical optics technology, 4-dimensional elastically scattered light fingerprinting, to show that in experimental colon carcinogenesis the predysplastic epithelial microvascular blood content is increased markedly. To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo. We developed a novel, endoscopically compatible, polarization-gated, spectroscopic probe that was capable of measuring oxygenated and deoxygenated (Dhb) hemoglobin specifically in the mucosal microcirculation through polarization gating. Microvascular blood content was measured in 222 patients from the endoscopically normal cecum, midtransverse colon, and rectum. If a polyp was present, readings were taken from the polyp tissue along with the normal mucosa 10-cm and 30-cm proximal and distal to the lesion. Tissue phantom studies showed that the probe had outstanding accuracy for hemoglobin determination (r(2) = 0.99). Augmentation of microvasculature blood content was most pronounced within the most superficial ( approximately 100 microm) layer and dissipated in deeper layers (ie, submucosa). EIBS was detectable within 30 cm from the lesion and the magnitude mirrored adenoma proximity. This occurred for both oxygenated hemoglobin and DHb, with the effect size being slightly greater for DHb. EIBS correlated with adenoma size and was not engendered by nonneoplastic (hyperplastic) polyps. We show, herein, that in vivo microvascular blood content can be measured and provides an accurate marker of field carcinogenesis. This technological/biological advance has numerous potential applications in colorectal cancer screening such as improved polyp detection and risk stratification.

  5. Uric acid is associated with inflammation, coronary microvascular dysfunction, and adverse outcomes in postmenopausal women

    Science.gov (United States)

    Prasad, Megha; Matteson, Eric L.; Herrmann, Joerg; Gulati, Rajiv; Rihal, Charanjit S.; Lerman, Lilach O.; Lerman, Amir

    2016-01-01

    Uric acid is a risk factor for coronary artery disease (CAD) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction (CED) is not well-defined. The aim of this study was to determine the relationship of serum uric acid (SUA), inflammatory markers and CED. In this prospective cohort study, serum uric acid, hsCRP levels, and neutrophil count were measured in 229 postmenopausal women who underwent diagnostic catheterization, were found to have no obstructive CAD and underwent coronary microvascular function testing, to measure coronary blood flow (CBF) response to intracoronary acetylcholine. The average age was 58 years (IQR 52, 66) years. Hypertension was present in 48%, type 2 diabetes mellitus in 5.6%, and hyperlipidemia in 61.8%. CED was diagnosed in 59% of postmenopausal women. Mean uric acid level was 4.7 ± 1.3 mg/dL. Postmenopausal women with CED had significantly higher SUA compared to patients without CED (4.9 ± 1.3 vs. 4.4 ± 1.3 mg/dL; p=0.02). There was a significant correlation between SUA and % change in CBF to acetylcholine (p=0.009), and this correlation persisted in multivariable analysis. SUA levels were significantly associated with increased neutrophil count (p=0.02) and hsCRP levels (p=0.006) among patients with CED, but not those without CED. Serum uric acid is associated with coronary microvascular endothelial dysfunction in postmenopausal women and may be related to inflammation. These findings link serum uric acid levels to early coronary atherosclerosis in postmenopausal women. PMID:27993955

  6. The reliability of a single protocol to determine endothelial, microvascular and autonomic functions in adolescents.

    Science.gov (United States)

    Bond, Bert; Williams, Craig A; Barker, Alan R

    2017-11-01

    Impairments in macrovascular, microvascular and autonomic function are present in asymptomatic youths with clustered cardiovascular disease risk factors. This study determines the within-day reliability and between-day reliability of a single protocol to non-invasively assess these outcomes in adolescents. Forty 12- to 15-year-old adolescents (20 boys) visited the laboratory in a fasted state on two occasions, approximately 1 week apart. One hour after a standardized cereal breakfast, macrovascular function was determined via flow-mediated dilation (FMD). Heart rate variability (root mean square of successive R-R intervals; RMSSD) was determined from the ECG-gated ultrasound images acquired during the FMD protocol prior to cuff occlusion. Microvascular function was simultaneously quantified as the peak (PRH) and total (TRH) hyperaemic response to occlusion in the cutaneous circulation of the forearm via laser Doppler imaging. To address within-day reliability, a subset of twenty adolescents (10 boys) repeated these measures 90 min afterwards on one occasion. The within-day typical error and between-day typical error expressed as a coefficient of variation of these outcomes are as follows: ratio-scaled FMD, 5·1% and 10·6%; allometrically scaled FMD, 4·4% and 9·4%; PRH, 11% and 13·3%; TRH, 29·9% and 23·1%; and RMSSD, 17·6% and 17·6%. The within- and between-day test-retest correlation coefficients for these outcomes were all significant (r > 0·54 for all). Macrovascular, microvascular and autonomic functions can be simultaneously and non-invasively determined in adolescents using a single protocol with an appropriate degree of reproducibility. Determining these outcomes may provide greater understanding of the progression of cardiovascular disease and aid early intervention. © 2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  7. Associations between diabetes self-management and microvascular complications in patients with type 2 diabetes

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    Fatemeh Mehravar

    2016-01-01

    Full Text Available OBJECTIVES: Diabetes is a major public health problem that is approaching epidemic proportions globally. Diabetes self-management can reduce complications and mortality in type 2 diabetic patients. The purpose of this study was to examine associations between diabetes self-management and microvascular complications in patients with type 2 diabetes. METHODS: In this cross-sectional study, 562 Iranian patients older than 30 years of age with type 2 diabetes who received treatment at the Diabetes Research Center of the Endocrinology and Metabolism Research Institute of the Tehran University of Medical Sciences were identified. The participants were enrolled and completed questionnaires between January and April 2014. Patients’ diabetes self-management was assessed as an independent variable by using the Diabetes Self-Management Questionnaire translated into Persian. The outcomes were the microvascular complications of diabetes (retinopathy, nephropathy, and neuropathy, identified from the clinical records of each patient. A multiple logistic regression model was used to estimate odds ratios (ORs and 95% confidence intervals (CIs between diabetes self-management and the microvascular complications of type 2 diabetes, adjusting for potential confounders. RESULTS: After adjusting for potential confounders, a significant association was found between the diabetes self-management sum scale and neuropathy (adjusted OR, 0.64; 95% CI, 0.45 to 0.92, p=0.01. Additionally, weak evidence was found of an association between the sum scale score of diabetes self-management and nephropathy (adjusted OR, 0.71; 95% CI, 0.47 to 1.05, p=0.09. CONCLUSIONS: Among patients with type 2 diabetes, a lower diabetes self-management score was associated with higher rates of nephropathy and neuropathy.

  8. Depth-dependent flow and pressure characteristics in cortical microvascular networks.

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    Franca Schmid

    2017-02-01

    Full Text Available A better knowledge of the flow and pressure distribution in realistic microvascular networks is needed for improving our understanding of neurovascular coupling mechanisms and the related measurement techniques. Here, numerical simulations with discrete tracking of red blood cells (RBCs are performed in three realistic microvascular networks from the mouse cerebral cortex. Our analysis is based on trajectories of individual RBCs and focuses on layer-specific flow phenomena until a cortical depth of 1 mm. The individual RBC trajectories reveal that in the capillary bed RBCs preferentially move in plane. Hence, the capillary flow field shows laminar patterns and a layer-specific analysis is valid. We demonstrate that for RBCs entering the capillary bed close to the cortical surface (< 400 μm the largest pressure drop takes place in the capillaries (37%, while for deeper regions arterioles are responsible for 61% of the total pressure drop. Further flow characteristics, such as capillary transit time or RBC velocity, also vary significantly over cortical depth. Comparison of purely topological characteristics with flow-based ones shows that a combined interpretation of topology and flow is indispensable. Our results provide evidence that it is crucial to consider layer-specific differences for all investigations related to the flow and pressure distribution in the cortical vasculature. These findings support the hypothesis that for an efficient oxygen up-regulation at least two regulation mechanisms must be playing hand in hand, namely cerebral blood flow increase and microvascular flow homogenization. However, the contribution of both regulation mechanisms to oxygen up-regulation likely varies over depth.

  9. Rat Pial Microvascular Changes During Cerebral Blood Flow Decrease and Recovery: Effects of Cyanidin Administration

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    Teresa Mastantuono

    2018-05-01

    Full Text Available The reactive oxygen species (ROS are known to play a major role in many pathophysiological conditions, such as ischemia and reperfusion injury. The present study was aimed to evaluate the in vivo cyanidin (anthocyanin effects on damages induced by rat pial microvascular hypoperfusion-reperfusion injury by cerebral blood flow decrease (CBFD and subsequent cerebral blood flow recovery (CBFR. In particular, the main purpose was to detect changes in ROS production after cyanidin administration. Rat pial microvasculature was investigated using fluorescence microscopy through a cranial window (closed; Strahler's method was utilized to define the geometric features of pial vessels. ROS production was investigated in vivo by 2′-7′-dichlorofluorescein-diacetate assay and neuronal damage was measured on isolated brain sections by 2,3,5-triphenyltetrazolium chloride staining. After 30 min of CBFD, induced by bilateral common carotid artery occlusion, and 60 min of CBFR, rats showed decrease of arteriolar diameter and capillary perfusion; furthermore, increase in microvascular leakage and leukocyte adhesion was observed. Conversely, cyanidin administration induced dose-related arteriolar dilation, reduction in microvascular permeability as well as leukocyte adhesion when compared to animals subjected to restriction of cerebral blood flow; moreover, capillary perfusion was protected. ROS generation increase and marked neuronal damage were detected in animals subjected to CBFD and CBFR. On the other hand, cyanidin was able to reduce ROS generation and neuronal damage. In conclusion, cyanidin treatment showed dose-related protective effects on rat pial microcirculation during CBFD and subsequent CBFR, inducing arteriolar dilation by nitric oxide release and inhibiting ROS formation, consequently preserving the blood brain barrier integrity.

  10. Microvascular volume in symptomatic Achilles tendons is associated with VISA-A score.

    Science.gov (United States)

    Praet, S F E; Ong, J H; Purdam, C; Welvaert, M; Lovell, G; Dixon, L; Gaida, J E; Anglim, J; Manzanero, S; Vlahovich, N; Hughes, D; Waddington, G

    2018-05-15

    The role of neovascularisation in tendinopathy is still poorly understood, potentially due to technical limitations of conventional power Doppler ultrasound. This study aimed to investigate the association between contrast-enhanced ultrasound (CEUS) microvascular volume (MV), Victorian Institute of Sports Assessment-Achilles (VISA-A) scores and intrinsic Achilles tendon tenderness, as well as two different Power Doppler modes. Cross-sectional study. 20 individuals with uni- or bilateral Achilles tendinopathy completed a VISA-A questionnaire, and underwent microvascular volume measurements of the Achilles tendon mid-portion using both conventional, ultrasensitive (SMI™) power Doppler ultrasound and CEUS. Intrinsic tendon tenderness was assessed with sensation detection threshold to extracorporeal shock waves (ESW). Linear Mixed Model analysis was used to determine the association between microvascular volume (MV), VISA-A, and ESW-detection threshold for both symptomatic and asymptomatic Achilles tendons. There was a significant association between VISA-A and MV (B=-5.3, 95%CI=[-8.5; -2.0], P=0.0004), and between MV and symptom duration (B=-1.7, 95%CI=[-3.2; -5.0], P=0.023). No significant associations were found between power Doppler ultrasound and CEUS-based MV or between CEUS-based MV and ESW-detection threshold. In comparison with conventional power Doppler ultrasound, SMI™ showed on average similar detection capacity for neovessels in the mid-portion of the Achilles tendon, whilst being superior for detecting neovessels within Kager's fat pad (t=3.46, 95%CI=[0.27; 1.03], P<0.005). Our results indicate that CEUS-based MV of the Achilles tendon is moderately associated with Achilles tendon symptoms. In accordance, CEUS-detected MV could be a novel target for treatment as it seems to be more sensitive than PDU and is correlated with symptoms. Copyright © 2018 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  11. Escleroterapia con bleomicina en malformaciones vasculares de bajo flujo: Experiencia y revisión del tema Bleomycin sclerotherapy for low-flow vascular malformations: our experience and literature review

    Directory of Open Access Journals (Sweden)

    F. Lobo Bailón

    2012-12-01

    Full Text Available Las anomalías vasculares son lesiones típicas de los pacientes pediátricos y se dividen en dos categorías: tumores vasculares y malformaciones vasculares de alto y bajo flujo. Estas últimas pueden tratarse de diversos modos: laserterapia, drenaje, aspiración, cirugía o escleroterapia, dependiendo del tipo de lesión y de su localización. Entre los agentes esclerosantes utilizados, la bleomicina ha demostrado tener buenos resultados en el tratamiento de estas lesiones. En este artículo presentamos nuestra experiencia en el tratamiento de las malformaciones vasculares de bajo flujo mediante escleroterapia con bleomicina intralesional. Desarrollamos un estudio descriptivo retrospectivo sobre 30 pacientes que presentaban malformación vascular de bajo flujo y fueron tratados con bleomicina intralesional. Los resultados fueron buenos o excelentes en 22 pacientes y regulares o malos en los 8 restantes. De acuerdo a nuestra casuística y a la literatura revisada, la escleroterapia con bleomicina es una alternativa terapéutica eficaz y segura en el tratamiento de las malformaciones vasculares de bajo flujo.Vascular anomalies are common in children and can be divided into two categories, vascular tumours and vascular malformations: high-flow or low-flow. The latter can be treated in different ways such as lasertherapy, drainage, aspiration, surgery or sclerotherapy depending on the type and location of the lesion. Among the accepted sclerosing agents, bleomycin has proven good results in the treatment of this condition. Herein we present our experience in the treatment of low-flow vascular malformations with intralesional bleomycin injection. This is a retrospective, descriptive study with 30 patients presenting a low-flow vascular malformation treated with intralesional bleomycin injection. Our results are good or excellent in 22 patients and poor in the other 8. According to our case series and the consulted literature, sclerotherapy with

  12. [Reconstruction of oral mucosa with a micro-vascularized fascia-cutaneous flap from the forearm].

    Science.gov (United States)

    Burgueño García, Miguel; Cebrián Carretero, José Luis; Muñoz Caro, Jesús Manuel; Arias Gallo, Javier

    2002-01-01

    Epidermoid carcinoma of jugal mucosa is an aggressive tumor. Its treatment is based on broad excision and reconstruction in order to avoid fibrosis and restriction of mouth opening. Neck dissection and radiotherapy are indicated in selected cases. We display our experience with microvascularized flaps with the aim of preventing the flaws. We reconsider 8 patients (representing 10 flaps) handle in our Department. Besides we discuss other therapeutic alternatives after the growth's removal. The conclusion reached is that the mucovascularized forearm flaps give a great quantity of thin tissue and therefore so results to be the best option for the reconstruction of the jugal mucosa.

  13. Autologous Latissimus Dorsi Breast Reconstruction Flap Salvage: Microvascular Anastomosis with Serratus Branch

    Directory of Open Access Journals (Sweden)

    Victoria Kuta, BScH

    2017-07-01

    Full Text Available Summary:. Autologous breast reconstruction has become a standard option during the recovery of breast cancer survivors. Although pedicle damage is a rare complication of this procedure, extensive torsion or tension can lead to partial or total flap failure. We report a case of partial flap salvage after accidental transection of the pedicled blood supply within the intramuscular course of a latissimus dorsi musculocutaneous flap. This salvage technique involved microvascular anastomosis between the remaining vasculature of the latissimus dorsi pedicle and the serratus branch of the thoracodorsal artery and vein.

  14. Magnetic alginate microfibers as scaffolding elements for the fabrication of microvascular-like structures.

    Science.gov (United States)

    Sun, Tao; Shi, Qing; Huang, Qiang; Wang, Huaping; Xiong, Xiaolu; Hu, Chengzhi; Fukuda, Toshio

    2018-01-15

    Traditional cell-encapsulating scaffolds may elicit adverse host responses and inhomogeneity in cellular distribution. Thus, fabrication techniques for cellular self-assembly with micro-scaffold incorporation have been used recently to generate toroidal cellular modules for the bottom-up construction of vascular-like structures. The micro-scaffolds show advantage in promoting tissue formation. However, owing to the lack of annular cell micro-scaffolds, it remains a challenge to engineer micro-scale toroidal cellular modules (micro-TCMs) to fabricate microvascular-like structures. Here, magnetic alginate microfibers (MAMs) are used as scaffolding elements, where a winding strategy enables them to be formed into micro-rings as annular cell micro-scaffolds. These micro-rings were investigated for NIH/3T3 fibroblast growth as a function of surface chemistry and MAM size. Afterwards, micro-TCMs were successfully fabricated with the formation of NIH/3T3 fibroblasts and extracellular matrix layers on the three-dimensional micro-ring surfaces. Simple non-contact magnetic assembly was used to stack the micro-TCMs along a micro-pillar, after which cell fusion rapidly connected the assembled micro-TCMs into a microvascular-like structure. Endothelial cells or drugs encapsulated in the MAMs could be included in the microvascular-like structures as in vitro cellular models for vascular tissue engineering, or as miniaturization platforms for pharmaceutical drug testing in the future. Magnetic alginate microfibers functioned as scaffolding elements for guiding cell growth in micro-scale toroidal cellular modules (micro-TCMs) and provided a magnetic functionality to the micro-TCMs for non-contact 3D assembly in external magnetic fields. By using the liquid/air interface, the non-contact spatial manipulation of the micro-TCMs in the liquid environment was performed with a cost-effective motorized electromagnetic needle. A new biofabrication paradigm of construct of microvascular

  15. Optical measurements of microvascular circulatory function in the foot for detection of peripheral neuropathy

    Science.gov (United States)

    Zamora, G.; Chekh, V.; Burge, M.; Barriga, E. S.; Luan, S.; Heintz, P.; Edwards, A.; McGrew, E.; Soliz, P.

    2012-03-01

    The purpose of this research is to quantify functional signals in the microvascular circulation of the plantar. Our device is based on thermal and spectral technologies that can be easily adopted in clinical and tele-screening settings. Eightytwo thousand amputations are performed annually on diabetics in the US. The cost of foot disorder diagnosis and management are estimated at $10.9 billion dollars annually. Our experiments on normal controls and diabetics assess the temperature recovery time characteristics due to cold provocation to the bottom of the foot (plantar). A difference in the nature of the recovery time between normal controls and diabetics was observed.

  16. Longitudinal study of microvascular involvement by nailfold capillaroscopy in children with Henoch-Schönlein purpura.

    Science.gov (United States)

    Zampetti, Anna; Rigante, Donato; Bersani, Giulia; Rendeli, Claudia; Feliciani, Claudio; Stabile, Achille

    2009-09-01

    The aim of this study is to describe by video-nailfold capillaroscopy the microvascular involvement and capillary changes in children with Henoch-Schönlein purpura (HSp) and to establish a possible correlation with clinical outcome. Thirty-one patients underwent capillaroscopic evaluation through a videomicroscope during the acute phase and after 6 months. Twenty sex/age-matched controls were also examined. All capillaroscopic variables were statistically examined in combination with laboratoristic/clinical data. Architectural and morphological changes recorded during the acute phase were statistically significant in comparison to the controls (p capillaroscopy changes, laboratoristic/clinical data, and outcome. Video-nailfold capillaroscopy can be a simple tool to evaluate microvascular abnormalities in the acute phase of HSp, and the persistence of oedema could suggest an incomplete disease resolution at a microvascular level.

  17. Revolución y contrarrevolución en la ciudad global: las expectativas frustradas por la globalización de nuestras ciudades

    Directory of Open Access Journals (Sweden)

    Jordi Borja

    2007-12-01

    Full Text Available El análisis pesimista, incluso catastrófico, prevalece en los estudios sobre la urbanización global. Por ejemplo, los Informes de PNUD-Habkat o del Worldwatch Institut. O los artículos e intervenciones en encuentros intelectuales. Lo cual no obsta que se reconozca el potencial transformador e integrador de las ciudades. El discurso positivo sobre las libertades ciudadanas que la revolución urbana en curso hace posible forma parte de nuestra cultura. Son dos caras de la realidad. Muchas ciudades, europeas y americanas, han promovido la renovación de sus áreas centrales, que, en muchos casos, abarca casi todo el municipio con una revalorización de la ciudad compacta y heterogénea, caracterizada por la calidad del espacio público. Pero los desarrollos urbanos, las regiones metropolitanas, multiplican las desigualdades en el territorio, generan espacios confusos, físicamente fragmentados y socialmente segregadores. La revolución urbana actual es frustrante. El desafío político, urbanístico y cultural es hoy "hacer ciudad" en el conjunto de las regiones caracterizadas por la urbanizaciónA pessimistic analysis, even catastrophic, prevails in studies of global urbanization. For example, the Reports of the UNDP-Habitat or the Worldwatch Institute, or the articles and presentations in intellectual fora. This does not mean that the transformative and integrative potential of cities is not recognized. The positive discourse about citizens' liberties that the urban revolution, currently in process, makes possible forms part of our culture. These are the two sides of this reality. Many cities, European and American, have promoted regeneration of their central areas that, in many cases, deal with almost an entire municipality, with a revaluing of the compact, heterogenous city characterized by the quality of public space. However the urban developments, the metropolitan regions, multiply inequalities over the landscape, generating spaces that

  18. Coronary Microvascular Function and Cardiovascular Risk Factors in Women With Angina Pectoris and No Obstructive Coronary Artery Disease

    DEFF Research Database (Denmark)

    Mygind, Naja Dam; Michelsen, Marie Mide; Peña, Adam

    2016-01-01

    BACKGROUND: The majority of women with angina-like chest pain have no obstructive coronary artery disease when evaluated with coronary angiography. Coronary microvascular dysfunction is a possible explanation and associated with a poor prognosis. This study evaluated the prevalence of coronary...... microvascular dysfunction and the association with symptoms, cardiovascular risk factors, psychosocial factors, and results from diagnostic stress testing. METHODS AND RESULTS: After screening 3568 women, 963 women with angina-like chest pain and a diagnostic coronary angiogram without significant coronary.......01), hypertension (P=0.02), current smoking (Ppain characteristics or results from diagnostic stress testing...

  19. Evaluation of applicability and efficacy of the reconstructive microvascular surgery of advanced cancer of the lower face with mandible infiltration

    International Nuclear Information System (INIS)

    Maciejewski, A.

    2008-01-01

    The aim of this study is to evaluate applicability and efficacy of reconstructive and microvascular surgery for patients with locally advanced cancer of the lower face with mandible infiltration, regarding to various technique of mandible and tongue reconstruction using flaps and to own modifications. Complex quality of life including functional, aesthetic, social and effect has also been evaluated. For patients with advanced cancer of the region infiltrating mandible reconstructive and microvascular surgery as a sole modality or combined with postoperative radiotherapy, is effective method of radical treatment, providing 80% of chance of 3-year disease-free survival and reduces the risk of recurrence by 60%. (author)

  20. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress

    Science.gov (United States)

    Greaney, Jody L; DuPont, Jennifer J; Lennon-Edwards, Shannon L; Sanders, Paul W; Edwards, David G; Farquhar, William B

    2012-01-01

    Animal studies have reported dietary salt-induced reductions in vascular function independent of increases in blood pressure (BP). The purpose of this study was to determine if short-term dietary sodium loading impairs cutaneous microvascular function in normotensive adults with salt resistance. Following a control run-in diet, 12 normotensive adults (31 ± 2 years) were randomized to a 7 day low-sodium (LS; 20 mmol day−1) and 7 day high-sodium (HS; 350 mmol day−1) diet (controlled feeding study). Salt resistance, defined as a ≤5 mmHg change in 24 h mean BP determined while on the LS and HS diets, was confirmed in all subjects undergoing study (LS: 84 ± 1 mmHg vs. HS: 85 ± 2 mmHg; P > 0.05). On the last day of each diet, subjects were instrumented with two microdialysis fibres for the local delivery of Ringer solution and 20 mm ascorbic acid (AA). Laser Doppler flowmetry was used to measure red blood cell flux during local heating-induced vasodilatation (42°C). After the established plateau, 10 mm l-NAME was perfused to quantify NO-dependent vasodilatation. All data were expressed as a percentage of maximal cutaneous vascular conductance (CVC) at each site (28 mm sodium nitroprusside; 43°C). Sodium excretion increased during the HS diet (P sodium loading impairs cutaneous microvascular function independent of BP in normotensive adults and suggest a role for oxidative stress. PMID:22907057

  1. Role of aldose reductase C-106T polymorphism among diabetic Egyptian patients with different microvascular complications

    Directory of Open Access Journals (Sweden)

    Nermine Hossam Zakaria

    2014-04-01

    Full Text Available The aldose reductase pathway proves that elevated blood glucose promotes cellular dysfunction. The polyol pathway converts excess intracellular glucose into alcohols via activity of the aldose reductase. This enzyme catalyzes the conversion of glucose to sorbitol which triggers variety of intracellular changes in the tissues. Among diabetes, activity is drastically increased in association with three main consequences inside the cells. The aim of this study was to detect the association of the C-106 T polymorphism of the aldose reductase gene and its frequency among a sample of 150 Egyptian adults with type 2 diabetic patients having diabetic microvascular. The detection of the aldose reductase C-106 T polymorphism gene was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP. The genotype distribution of the C-106 T polymorphism showed that CC genotype was statistically significantly higher among patients with retinopathy compared to nephropathy. Patients with nephropathy had significant association with the TT genotype when compared with diabetic retinopathy patients. Follow up study after the genotype detection among recently diagnosed diabetic patients in order to give a prophylactic aldose reductase inhibitors; studying the microvascular complications and its relation to the genotype polymorphisms. The study may include multiple gene polymorphisms to make the relation between the gene and the occurrence of these complications more evident.

  2. Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

    Science.gov (United States)

    Huang, Yong; Tong, Dedi; Zhu, Shan; Wu, Lehao; Ibrahim, Zuhaib; Lee, WP Andrew; Brandacher, Gerald; Kang, Jin U.

    2014-03-01

    Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon's observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

  3. Microvascular decompression for the patient with painful tic convulsif after Bell palsy.

    Science.gov (United States)

    Jiao, Wei; Zhong, Jun; Sun, Hui; Zhu, Jin; Zhou, Qiu-Meng; Yang, Xiao-Sheng; Li, Shi-Ting

    2013-05-01

    Painful tic convulsif is referred to as the concurrent trigeminal neuralgia and hemifacial spasm. However, painful tic convulsif after ipsilateral Bell palsy has never been reported before. We report a case of a 77-year-old woman with coexistent trigeminal neuralgia and hemifacial spasm who had experienced Bell palsy half a year ago. The patient underwent microvascular decompression. Intraoperatively, the vertebrobasilar artery was found to deviate to the symptomatic side and a severe adhesion was observed in the cerebellopontine angle. Meanwhile, an ectatic anterior inferior cerebellar artery and 2 branches of the superior cerebellar artery were identified to compress the caudal root entry zone (REZ) of the VII nerve and the rostroventral cisternal portion of the V nerve, respectively. Postoperatively, the symptoms of spasm ceased immediately and the pain disappeared within 3 months. In this article, the pathogenesis of the patient's illness was discussed and it was assumed that the adhesions developed from inflammatory reactions after Bell palsy and the anatomic features of the patient were the factors that generated the disorder. Microvascular decompression surgery is the suggested treatment of the disease, and the dissection should be started from the caudal cranial nerves while performing the operation.

  4. Radioisotope albumin flux measurement of microvascular lung permeability: an independent parameter in acute respiratory failure?

    International Nuclear Information System (INIS)

    Hoegerle, S.; Nitzsche, E.U.; Reinhardt, M.J.; Moser, E.; Benzing, A.; Geiger, K.; Schulte Moenting, J.

    2001-01-01

    Aim: To evaluate the extent to which single measurements of microvascular lung permeability may be relevant as an additional parameter in a heterogenous clinical patient collective with Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Methods: In 36 patients with pneumonia (13), non pneumogenic sepsis (9) or trauma (14) meeting the consensus conference criteria of ALI or ARDS double-isotope protein flux measurements ( 51 Cr erythrocytes as intravascular tracer, Tc-99m human albumin as diffusible tracer) of microvascular lung permeability were performed using the Normalized Slope Index (NSI). The examination was to determine whether there is a relationship between the clinical diagnosis of ALI/ARDS, impaired permeability and clinical parameters, that is the underlying disease, oxygenation, duration of mechanical ventilation and mean pulmonary-artery pressure (PAP). Results: At the time of study, 25 patients presented with increased permeability (NSI > 1 x 10 -3 min -1 ) indicating an exudative stage of disease, and 11 patients with normal permeability. The permeability impairment correlated with the underlying disease (p > 0.05). With respect to survival, there was a negative correlation to PAP (p [de

  5. COMPARISON OF REAL-TIME MICROVASCULAR ABNORMALITIES IN PEDIATRIC AND ADULT SICKLE CELL ANEMIA PATIENTS

    Science.gov (United States)

    Cheung, Anthony T.W.; Miller, Joshua W.; Craig, Sarah M.; To, Patricia L.; Lin, Xin; Samarron, Sandra L.; Chen, Peter C.Y.; Zwerdling, Theodore; Wun, Ted; Li, Chin-Shang; Green, Ralph

    2010-01-01

    The conjunctival microcirculation in 14 pediatric and 8 adult sickle cell anemia (SCA) patients was studied using computer-assisted intravital microscopy. The bulbar conjunctiva in SCA patients in both age groups exhibited a blanched/avascular appearance characterized by decreased vascularity. SCA patients from both age groups had many of the same abnormal morphometric {vessel diameter, vessel distribution, morphometry (shape), tortuosity, arteriole:venule (A:V) ratio, and hemosiderin deposits} and dynamic {vessel sludging/sludged flow, boxcar blood (trickled) flow and abnormal flow velocity} abnormalities. A severity index (SI) was computed to quantify the degree of vasculopathy for comparison between groups. The severity of vasculopathy differed significantly between the pediatric and adult patients (SI: 4.2 ± 1.8 vs 6.6 ± 2.4; p=0.028), indicative of a lesser degree of overall severity in the pediatric patients. Specific abnormalities that were less prominent in the pediatric patients included abnormal vessel morphometry and tortuosity. Sludged flow, abnormal vessel distribution, abnormal A:V ratio, and boxcar flow, appeared in high prevalence in both age groups. The results indicate that SCA microvascular abnormalities develop in childhood and the severity of vasculopathy likely progresses with age. Intervention and effective treatment/management modalities should target pediatric patients to ameliorate, slow down or prevent progressive microvascular deterioration. PMID:20872552

  6. Intractable lung abscess successfully treated with cavernostomy and free omental plombage using microvascular surgery.

    Science.gov (United States)

    Shimizu, Junzo; Arano, Yoshihiko; Adachi, Iwao; Ikeda, Chikako; Ishikawa, Norihiko; Ohtake, Hiroshi

    2009-11-01

    A 68-year-old man, complaining of fever and puriform sputum, was referred to our hospital. A giant abscess was detected in the upper lobe of the right lung. Percutaneous drainage of a lung abscess was carried out. When the pus collected was cultured, Candida was 1+ and Escherichia coli was 2+. Later, it became difficult to control the abscess by drainage, and cavernostomy was selected. The contents of the abscess cavity were removed, and the cavity was opened, followed by exchange of gauze every day. For 14 months after cavernostomy, once-weekly gauze exchange was continued at the outpatient clinic to clean the abscess cavity. Finally, the abscess was filled with a free greater omentum flap, accompanied by microvascular anastomosis. In this way, the intractable lung abscess was successfully cured. Conventionally, surgical treatment, particularly cavernostomy, has been applied only to limited cases when dealing with a lung abscess. Our experience with the present case suggests that surgical treatment, including cavernostomy as one option, should also be considered when dealing with lung abscesses resisting medical treatment and causing compromised respiratory function. To enable maximum utilization of the greater omental flap, which is available in only a limited amount, it seems useful to prepare and graft a free omental flap making use of microvascular surgery.

  7. Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet.

    Science.gov (United States)

    Mastantuono, T; Di Maro, M; Chiurazzi, M; Battiloro, L; Starita, N; Nasti, G; Lapi, D; Iuppariello, L; Cesarelli, M; D'Addio, G; Colantuoni, A

    2016-11-01

    The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in three groups: NW group (n=54), NG (n=54) and HG (n=54) groups were constituted by normal weight, normoglycemic and hyperglycemic obese subjects, respectively. SBF was measured by laser Doppler perfusion monitoring technique and oscillations in blood flow were analyzed by spectral methods under baseline conditions, at 3 and 6 months of dietary treatment. Under resting conditions, SBF was lower in HG group than in NG and NW ones. Moreover, all subjects showed blood flow oscillations with several frequency components. In particular, hyperglycemic obese patients revealed lower spectral density in myogenic-related component than normoglycemic obese and normal weight ones. Moreover, post-occlusive reactive hyperemia (PORH) was impaired in hyperglycemic obese compared to normoglycemic and normal weigh subjects. After hypocaloric diet, in hyperglycemic obese patients there was an improvement in SBF accompanied by recovery in myogenic-related oscillations and arteriolar responses during PORH. In conclusion, hyperglycemia markedly affected peripheral microvascular function; hypocaloric diet ameliorated tissue blood flow.

  8. Study of microvascular non-Newtonian blood flow modulated by electroosmosis.

    Science.gov (United States)

    Tripathi, Dharmendra; Yadav, Ashu; Anwar Bég, O; Kumar, Rakesh

    2018-05-01

    An analytical study of microvascular non-Newtonian blood flow is conducted incorporating the electro-osmosis phenomenon. Blood is considered as a Bingham rheological aqueous ionic solution. An externally applied static axial electrical field is imposed on the system. The Poisson-Boltzmann equation for electrical potential distribution is implemented to accommodate the electrical double layer in the microvascular regime. With long wavelength, lubrication and Debye-Hückel approximations, the boundary value problem is rendered non-dimensional. Analytical solutions are derived for the axial velocity, volumetric flow rate, pressure gradient, volumetric flow rate, averaged volumetric flow rate along one time period, pressure rise along one wavelength and stream function. A plug swidth is featured in the solutions. Via symbolic software (Mathematica), graphical plots are generated for the influence of Bingham plug flow width parameter, electrical Debye length and Helmholtz-Smoluchowski velocity (maximum electro-osmotic velocity) on the key hydrodynamic variables. This study reveals that blood flow rate accelerates with decreasing the plug width (i.e. viscoplastic nature of fluids) and also with increasing the Debye length parameter. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1).

    Science.gov (United States)

    Wieghaus, Kristen A; Nickerson, Meghan M; Petrie Aronin, Caren E; Sefcik, Lauren S; Price, Richard J; Paige, Mikell A; Brown, Milton L; Botchwey, Edward A

    2008-12-01

    Phthalimide neovascular factor (PNF1, formerly SC-3-149) is a potent stimulator of proangiogenic signaling pathways in endothelial cells. In this study, we evaluated the in vivo effects of sustained PNF1 release to promote ingrowth and expansion of microvascular networks surrounding biomaterial implants. The dorsal skinfold window chamber was used to evaluate the structural remodeling response of the local microvasculature. PNF1 was released from poly(lactic-co-glycolic acid) (PLAGA) films, and a transport model was utilized to predict PNF1 penetration into the surrounding tissue. PNF1 significantly expanded microvascular networks within a 2mm radius from implants after 3 and 7 days by increasing microvessel length density and lumenal diameter of local arterioles and venules. Staining of histological sections with CD11b showed enhanced recruitment of circulating white blood cells, including monocytes, which are critical for the process of vessel enlargement through arteriogenesis. As PNF1 has been shown to modulate MT1-MMP, a facilitator of CCL2 dependent leukocyte transmigration, aspects of window chamber experiments were repeated in CCR2(-/-) (CCL2 receptor) mouse chimeras to more fully explore the critical nature of monocyte recruitment on the therapeutic benefits of PNF1 function in vivo.

  10. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: Implications beyond GH release

    International Nuclear Information System (INIS)

    Li Aihua; Cheng Guangli; Zhu Genghui; Tarnawski, Andrzej S.

    2007-01-01

    Ghrelin, a peptide hormone isolated from the stomach, releases growth hormone and stimulates appetite. Ghrelin is also expressed in pancreas, kidneys, cardiovascular system and in endothelial cells. The precise role of ghrelin in endothelial cell functions remains unknown. We examined the expression of ghrelin and its receptor (GHSR1) mRNAs and proteins in human microvascular endothelial cells (HMVEC) and determined whether ghrelin affects in these cells proliferation, migration and in vitro angiogenesis; and whether MAPK/ERK2 signaling is important for the latter action. We found that ghrelin and GHSR1 are constitutively expressed in HMVEC. Treatment of HMVEC with exogenous ghrelin significantly increased in these cells proliferation, migration, in vitro angiogenesis and ERK2 phosphorylation. MEK/ERK2 inhibitor, PD 98059 abolished ghrelin-induced in vitro angiogenesis. This is First demonstration that ghrelin and its receptor are expressed in human microvascular endothelial cells and that ghrelin stimulates HMVEC proliferation, migration, and angiogenesis through activation of ERK2 signaling

  11. Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease.

    Science.gov (United States)

    Hughes, Alun D; Falaschetti, Emanuela; Witt, Nicholas; Wijetunge, Sumangali; Thom, Simon A McG; Tillin, Therese; Aldington, Steve J; Chaturvedi, Nish

    2016-11-01

    Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort. A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured. Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16-1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97-0.99]), fewer symmetrical arteriolar bifurcations (OR, 0.84 [95% CI, 0.75-0.95]), higher arteriolar optimality deviation (OR, 1.16 [95% CI, 1.00-1.34]), and more tortuous venules (OR, 1.20 [95% CI, 1.09-1.32]) were associated with strokes/infarcts and white matter hyperintensities. Associations with quantitative retinal microvascular measures were independent of retinopathy. Abnormalities of the retinal microvasculature are independently associated with stroke, cerebral infarcts, and white matter lesions. © 2016 American Heart Association, Inc.

  12. Microvascular disease in children and adolescents with type 1 diabetes and obesity.

    Science.gov (United States)

    Marcovecchio, M Loredana; Chiarelli, Francesco

    2011-03-01

    The incidence of type 1 diabetes (T1D) is increasing worldwide and is associated with a significant burden, mainly related to the development of vascular complications. Over the last decades, concomitant with the epidemic of childhood obesity, there has been an increasing number of cases of type 2 diabetes (T2D) among children and adolescents. Microvascular complications of diabetes, which include nephropathy, retinopathy and neuropathy, are characterized by damage to the microvasculature of the kidney, retina and neurons. Although clinically evident microvascular complications are rarely seen among children and adolescents with diabetes, there is clear evidence that their pathogenesis and early signs develop during childhood and accelerate during puberty. Diabetic vascular complications are often asymptomatic during their early stages, and once symptoms develop, there is little to be done to cure them. Therefore, screening needs to be started early during adolescence and, in the case of T2D, already at diagnosis. Identification of risk factors and subclinical signs of complications is essential for the early implementation of preventive and therapeutic strategies, which could change the course of vascular complications and improve the prognosis of children, adolescents and young adults with diabetes.

  13. Cyclic adenosine monophosphate levels and the function of skin microvascular endothelial cells.

    Science.gov (United States)

    Tuder, R M; Karasek, M A; Bensch, K G

    1990-02-01

    The maintenance of the normal epithelioid morphology of human dermal microvascular endothelial cells (MEC) grown in vitro depends strongly on the presence of factors that increase intracellular levels of cyclic AMP. Complete removal of dibutyryl cAMP and isobutylmethylxanthine (IMX) from the growth medium results in a progressive transition from an epithelioid to a spindle-shaped cell line. This transition cannot be reversed by the readdition of dibutyryl cAMP and IMX to the growth medium or by addition of agonists that increase cAMP levels. Spindle-shaped MEC lose the ability to express Factor VIII rAG and DR antigens and to bind peripheral blood mononuclear leukocyte (PBML). Ultrastructural analyses of transitional cells and spindle-shaped cells show decreased numbers of Weibel-Palade bodies in transitional cells and their complete absence in spindle-shaped cells. Interferon-gamma alters several functional properties of both epithelioid and spindle-shaped cells. In the absence of dibutyryl cAMP it accelerates the transition from epithelial to spindle-shaped cells, whereas in the presence of cyclic AMP interferon-gamma increases the binding of PBMLs to both epithelioid and spindle-shaped MEC and the endocytic activity of the endothelial cells. These results suggest that cyclic AMP is an important second messenger in the maintenance of several key functions of microvascular endothelial cells. Factors that influence the levels of this messenger in vivo can be expected to influence the angiogenic and immunologic functions of the microvasculature.

  14. Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions

    Directory of Open Access Journals (Sweden)

    Lefeng Wang

    2017-01-01

    Full Text Available Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC, leading to barrier dysfunction and acute respiratory distress syndrome (ARDS. Our recent work identified a strong correlation between PMVEC apoptosis and microvascular leak in septic mice in vivo, but the specific role of apoptosis in septic PMVEC barrier dysfunction remains unclear. Thus, we hypothesize that PMVEC apoptosis is likely required for PMVEC barrier dysfunction under septic conditions in vitro. Septic stimulation (mixture of tumour necrosis factor α, interleukin 1β, and interferon γ [cytomix] of isolated murine PMVEC resulted in a significant loss of barrier function as early as 4 h after stimulation, which persisted until 24 h. PMVEC apoptosis, as reflected by caspase activation, DNA fragmentation, and loss of membrane polarity, was first apparent at 8 h after cytomix. Pretreatment of PMVEC with the pan-caspase inhibitor Q-VD significantly decreased septic PMVEC apoptosis and was associated with reestablishment of PMVEC barrier function at 16 and 24 h after stimulation but had no effect on septic PMVEC barrier dysfunction over the first 8 h. Collectively, our data suggest that early septic murine PMVEC barrier dysfunction driven by proinflammatory cytokines is not mediated through apoptosis, but PMVEC apoptosis contributes to late septic PMVEC barrier dysfunction.

  15. Burocracias penales, administración institucional de conflictos y ciudadanía: Experiencia comparada entre Brasil y Argentina

    OpenAIRE

    Marta Fernández Patallo

    2010-01-01

    TISCORNIA Sofía, KANT DE LIMA Roberto y EILBAUM, Lucía (comp.). 2009. Burocracias penales, administración institucional de conflictos y ciudadanía. Experiencia comparada entre Brasil y Argentina. Buenos Aires: Antropofagia.

  16. Experiencias de la Corporación Universitaria Adventista en la doble titulación académica

    OpenAIRE

    Iglesias, Enoc; Corporación Adventista

    2015-01-01

    En el presente articulo no derivado de investigaciones, se muestran varios aspectos de las experiencias que ha tenido la Corporación Universitaria Adventista en la doble titulación, tema de gran actualidad.

  17. Una visión panorámica de las experiencias de Telesalud en Perú

    Directory of Open Access Journals (Sweden)

    Ernesto Gozzer Infante

    Full Text Available El artículo presenta las principales experiencias de telesalud realizadas en el Perú entre los años 2002 al 2010. Analiza información de literatura publicada y documentos no publicados acerca de experiencias de telesalud públicas y privadas. A partir de esta información se consultó con 26 expertos acerca de las características de las experiencias de telesalud identificadas. Se generó una base de datos de 38 experiencias, que se describen y analizan en esta publicación. Se presenta reflexiones y recomendaciones para ampliar el uso de la telesalud en el Perú

  18. La experiencia escolar más allá de la escuela: notas sobre un estudio de caso acerca de jóvenes y experiencia escolar

    OpenAIRE

    Crego, María Laura

    2014-01-01

    El presente trabajo tiene como objetivo compartir una serie de resultados y reflexiones alcanzados en el desarrollo de la tesina de grado de la carrera de Licenciatura en Sociología. En ella, se abordó la pregunta acerca de cómo construyen su experiencia escolar los y las jóvenes en contextos de pobreza. A este fin se desarrolló un estudio de caso en un barrio periférico de la ciudad de La Plata en el que se optó por estrategias cualitativas. El artículo presenta los principales res...

  19. EXPERIENCIAS PEDAGÓGICAS: Educar en las primeras infancias: una experiencia de formación docente en nutrición y alimentación saludable

    OpenAIRE

    Ravelli, Sandra; Manuale, Marcela

    2017-01-01

    El presente trabajo analiza una experiencia de formación docente centrada en la Educación Alimentaria Nutricional, que permitió fortalecer vínculos entre la universidad y otros nivelesdel sistema educativo, promoviendo intervenciones en la intersección entre educación, salud y primeras infancias. Desde la propuesta del Programa Nacional de Formación Permanente, del Ministerio de Educación de la Nación, se propuso desde la Facultad de  Bioquímica y Ciencias Biológicas (FBCB) de la Universidad ...

  20. Enseñar a aprender con TIC: una experiencia en el marco de un profesorado universitario

    OpenAIRE

    Martín, María Victoria; Vestfrid, Pamela

    2015-01-01

    Se presenta la experiencia llevada adelante en el “Taller Estrategias de trabajo colaborativo para el aula con redes sociales virtuales y otros asistentes online”, optativo para el Profesorado en Comunicación Social de la Facultad de Periodismo y Comunicación Social, UNLP. La misma busca brindar saberes conceptuales pero, fundamentalmente vivenciar experiencias de trabajo colaborativo que impliquen cambios en la esencia de los procesos educativos, modificando las verticales y desiguales relac...

  1. Subjetividad y socialidad en los fotologs. Juventud y nuevas formas de experiencias: la escritura hecha imagen

    Directory of Open Access Journals (Sweden)

    María Belén Espoz

    2011-01-01

    Full Text Available El presente trabajo ensaya algunas interpretaciones para comprender prácticas y experiencias de jóvenes en relación al uso y consumo de TIC, desde un cruce de lecturas que incluyen la semiótica de C. Sanders Peirce y la microsociología de Erving Goffman. ¿Qué tipos de experiencias se están produciendo en el marco de estas nuevas técnicas y como afectan (si lo hacen las formas de socialidad y su constitución subjetiva de los jóvenes en la actualidad? La importancia que los soportes/mediaciones tecnológicas adquieren en la vida cotidiana de los jóvenes abre el campo a nuevas indagaciones.

  2. Las violencias y los jóvenes universitarios, una experiencia para reflexionar

    Directory of Open Access Journals (Sweden)

    Noemí Ehrenfeld Lenkiewicz

    2016-01-01

    Full Text Available Este artículo pone de manifiesto aspectos poco o nada explorados de los estudiantes universitarios en relación con las violencias presentes en su cotidianidad, que afectan el desarrollo de su vida académica. A partir de una investigación sobre la percepción y las experiencias de las violencias en diferentes ámbitos se analiza el contexto que se vive en México y la participación de los jóvenes en las casuísticas. Las respuestas de los entrevistados que abordan experiencias propias brindan elementos que exigen pensar en una transformación educativa y pedagógica basada en la adquisición de habilidades para la vida.

  3. El rol del profesor y la actividad demostrativa: una experiencia de aula empleando Geogebra

    OpenAIRE

    Mejía, Cristina; Molina, Óscar

    2013-01-01

    En esta experiencia de aula presento un ciclo didáctico que forma parte del trabajo de grado que estoy desarrollando para optar por el título de maestría en docencia de las Matemáticas. Pretendo exponer una experiencia en la que se analiza el rol del profesor, bajo la teoría de la mediación semiótica y fundamentado en la aproximación metodológica para la enseñanza del grupo Æ•G. Tal ciclo planteado en un aula de octavo grado, favorece la construcción de un sistema teórico local y se emplea un...

  4. Música y experiencia: De las "sociedades primitivas" a las redes sociales

    Directory of Open Access Journals (Sweden)

    Israel V. Mázquez

    2011-05-01

    Full Text Available El artículo traza un itinerario circular que parte de la experiencia musical en su sentido tradicional de interacción y actividad grupal, sigue con algunas de las características de la figura moderna del oyente solitario y su relación con el espacio público y privado, y termina con las nuevas tecnologías de la información y las redes sociales de la web 2.0, las cuales hacen posible nuevas formas de interactividad y nuevas maneras de fortalecer los lazos de afiliación y sociabilidad a través de la música, hecho que aquí interpretamos como un retorno a los orígenes grupales y comunitarios de la experiencia musical.

  5. Experiencias caseras que muestran aspectos del funcionamiento de la vista, el gusto y el tacto

    Directory of Open Access Journals (Sweden)

    Juan A. Navarro de Tuero

    2011-01-01

    Full Text Available En el laboratorio de Biología explicamos el funcionamiento de algunos de nuestros órganos de los sentidos (vista, olfato, gusto y tacto a través de una serie de experiencias que a lo largo de los años han evidenciado ser muy didácticas. Muestran parte del proceso físico en sí y, al exigir la participación activa del alumnado, permiten que éste aprenda divirtiéndose. Lo fácil y barato que resulta realizar estas experiencias, junto a su gran capacidad de generar asombro, invitan a su difusión y ejecución a todos los niveles.

  6. Experiencias caseras que muestran aspectos del funcionamiento de la vista, el gusto y el tacto

    Directory of Open Access Journals (Sweden)

    Juan A. Navarro de Tuero

    2011-04-01

    Full Text Available En el laboratorio de Biología explicamos el funcionamiento de algunos de nuestros órganos de los sentidos (vista, olfato, gusto y tacto a través de una serie de experiencias que a lo largo de los años han evidenciado ser muy didácticas. Muestran parte del proceso físico en sí y, al exigir la participación activa del alumnado, permiten que éste aprenda divirtiéndose. Lo fácil y barato que resulta realizar estas experiencias, junto a su gran capacidad degenerar asombro, invitan a su difusión y ejecución a todos los niveles.

  7. Experiencias e interpretaciones en performances rituales (Iruya y El Cajón, noroeste argentino

    Directory of Open Access Journals (Sweden)

    Karen Avenburg

    2014-07-01

    Full Text Available Este artículo se propone reflexionar acerca del modo en que dos performances rituales del noroeste argentino recrean en sus puestas en escena diferentes experiencias. Desde un enfoque etnográfico apoyado en los respectivos trabajos de campo de las autoras, se analizan comparativamente la Fiesta Patronal de la Virgen del Rosario de Iruya (Salta y la Semana Santa de El Cajón (Catamarca. En particular, se discuten algunas de las razones por la cuales en un contexto ritual la puesta en escena implica la recreación de su historia sociocultural y política, mientras que en el otro el eje central transcurre reactualizando eventos cosmológicos. El marco teórico utilizado se basa en el concepto de performance y su relación con la experiencia, siguiendo los aportes realizados por Edward Bruner y Victor Turner.

  8. Investigación educativa: la experiencia en el estado de Chihuahua

    Directory of Open Access Journals (Sweden)

    Evangelina Cervantes Holguín

    2016-04-01

    Full Text Available Este ensayo tiene como propósito recuperar las experiencias de investigación de los académicos e instituciones superiores establecidas en la región. Asimismo, permite conocer el estado que guarda esta actividad intelectual y el desarrollo que ha tenido el campo de la educación en el estado de Chihuahua. De manera concreta se establecen cuatro etapas: antecedentes, primeras experiencias de investigación (1984 a 1990; cambios y desafíos (1990 al 2000; crecimiento (2000 al 2009 y apertura y expansión (2009. En esta última fase, se destaca la pertinencia de la Rediech como espacio para generar, desarrollar, fortalecer y difundir la actividad investigativa en esta entidad.

  9. The relationship of body fatness and body fat distribution with microvascular recruitment : The Amsterdam Growth and Health Longitudinal Study

    NARCIS (Netherlands)

    Wijnstok, N.J.; Hoekstra, T.; Eringa, E.C.; Smulders, Y.M.; Twisk, J.W.; Serne, E.H.

    INTRODUCTION: Microvascular function has been proposed to link body fatness to CVD and DM2. Current knowledge of these relationships is mainly based on studies in selected populations of extreme phenotypes. Whether these findings can be translated to the general population remains to be

  10. Functional Response of Tumor Vasculature to PaCO2: Determination of Total and Microvascular Blood Volume by MRI

    Directory of Open Access Journals (Sweden)

    Scott D. Packard

    2003-07-01

    Full Text Available In order to identify differences in functional activity, we compared the reactivity of glioma vasculature and the native cerebral vasculature to both dilate and constrict in response to altered PaCO2. Gliomas were generated by unilateral implantation of U87MGdEGFR human glioma tumor cells into the striatum of adult female athymic rats. Relative changes in total and microvascular cerebral blood volume were determined by steady state contrast agent-enhanced magnetic resonance imaging for transitions from normocarbia to hypercarbia and hypocarbia. Although hypercarbia induced a significant increase in both total and microvascular blood volume in normal brain and glioma, reactivity of glioma vasculature was significantly blunted in comparison to normal striatum; glioma total CBV increased by 0.6±0.1%/mm Hg CO2 whereas normal striatum increased by 1.5±0.2%/mm Hg CO2, (P < .0001, group t-test. Reactivity of microvascular blood volume was also significantly blunted. In contrast, hypocarbia decreased both total and microvascular blood volumes more in glioma than in normal striatum. These results indicate that cerebral blood vessels derived by tumor-directed angiogenesis do retain reactivity to CO2. Furthermore, reduced reactivity of tumor vessels to a single physiological perturbation, such as hypercarbia, should not be construed as a generalized reduction of functional activity of the tumor vascular bed.

  11. Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage

    DEFF Research Database (Denmark)

    Lundblad, Cornelia; Haanes, Kristian A; Grände, Gustaf

    2015-01-01

    , following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage. METHODS: In order to address this issue, we induced local inflammation in male Sprague-Dawley-rats dura mater by the addition of CFA or IS directly on the dural surface...

  12. Post-mortem computed tomography angiography utilizing barium sulfate to identify microvascular structures : a preliminary phantom model and case study

    NARCIS (Netherlands)

    Haakma, Wieke; Rohde, Marianne; Kuster, Lidy; Uhrenholt, Lars; Pedersen, Michael; Boel, Lene Warner Thorup

    2016-01-01

    We investigated the use of computer tomography angiography (CTA) to visualize microvascular structures in a vessel-mimicking phantom and post-mortem (PM) bodies. A contrast agent was used based on 22% barium sulfate, 20% polyethylene glycol and 58% distilled water. A vessel-mimicking phantom

  13. Reconstruction of mandibular defects after radiation, using a free, living bone, graft transferred by microvascular anastomoses. An experimental study

    International Nuclear Information System (INIS)

    Ostrup, L.T.; Fredrickson, J.M.

    1975-01-01

    The replacement of a mandibular defect by a free, composite rib graft, transferred by microvascular anastomoses of the posterior intercostal vessels to donor vessels in the neck was described previously. We now present data which demonstrate that successful results can be achieved even after radical mandibular radiation. This technique, done in dogs, has obvious implications in the management of oral cancer in man

  14. Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation.

    Science.gov (United States)

    Gagnon, Louis; Smith, Amy F; Boas, David A; Devor, Anna; Secomb, Timothy W; Sakadžić, Sava

    2016-01-01

    Oxygen is delivered to brain tissue by a dense network of microvessels, which actively control cerebral blood flow (CBF) through vasodilation and contraction in response to changing levels of neural activity. Understanding these network-level processes is immediately relevant for (1) interpretation of functional Magnetic Resonance Imaging (fMRI) signals, and (2) investigation of neurological diseases in which a deterioration of neurovascular and neuro-metabolic physiology contributes to motor and cognitive decline. Experimental data on the structure, flow and oxygen levels of microvascular networks are needed, together with theoretical methods to integrate this information and predict physiologically relevant properties that are not directly measurable. Recent progress in optical imaging technologies for high-resolution in vivo measurement of the cerebral microvascular architecture, blood flow, and oxygenation enables construction of detailed computational models of cerebral hemodynamics and oxygen transport based on realistic three-dimensional microvascular networks. In this article, we review state-of-the-art optical microscopy technologies for quantitative in vivo imaging of cerebral microvascular structure, blood flow and oxygenation, and theoretical methods that utilize such data to generate spatially resolved models for blood flow and oxygen transport. These "bottom-up" models are essential for the understanding of the processes governing brain oxygenation in normal and disease states and for eventual translation of the lessons learned from animal studies to humans.

  15. Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities : the Hoorn Study

    NARCIS (Netherlands)

    van Hecke, Manon V.; Dekker, Jacqueline M.; Nijpels, Giel; Teeerlink, Tom; Jakobs, Cornelis; Stolk, Ronald P.; Heine, Rob J.; Bouter, Lex M.; Polak, Bettine C. P.; Stehouwer, Coen D. A.

    The aim of the present study was to investigate the relationship between homocysteine and homocysteine metabolism components and retinal microvascular disorders in subjects with and without Type 2 diabetes. In this population-based study of 256 participants, aged 60-85 years, we determined total

  16. Low-dose dexamethasone-supplemented fluid resuscitation reverses endotoxin-induced acute renal failure and prevents cortical microvascular hypoxia

    NARCIS (Netherlands)

    Johannes, Tanja; Mik, Egbert G.; Klingel, Karin; Dieterich, Hans-Jürgen; Unertl, Klaus E.; Ince, Can

    2009-01-01

    There is growing evidence that impairment in intrarenal oxygenation and hypoxic injury might contribute to the pathogenesis of septic renal failure. An important molecule known to act on the renal microvascular tone and therefore consequently being involved in the regulation of intrarenal oxygen

  17. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats

    NARCIS (Netherlands)

    Legrand, Matthieu; Almac, Emre; Mik, Egbert G.; Johannes, Tanja; Kandil, Asli; Bezemer, Rick; Payen, Didier; Ince, Can

    2009-01-01

    Legrand M, Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Am J Physiol Renal Physiol 296: F1109-F1117, 2009. First published February 18, 2009;

  18. Cardiovascular Magnetic Resonance T2-STIR Imaging is Unable to Discriminate Between Intramyocardial Haemorrhage and Microvascular Obstruction

    DEFF Research Database (Denmark)

    Søvsø Szocska Hansen, Esben; Pedersen, Steen Fjord; Pedersen, Steen Bønløkke

    2015-01-01

    Recent studies have used cardiovascular magnetic resonance (CMR) and T2-weighted short tau inversion recovery (T2-STIR) imaging to detect intramyocardial haemorrhage (IMH) as a measure of ischemic/reperfusion injury. We investigated the ability of T2-STIR to differentiate between microvascular...

  19. Esferocitosis hereditaria: experiencia clínica y diagnóstica en Argentina

    OpenAIRE

    Crisp, Renée Leonor; García, Eliana; Solari, Liliana; Rapetti, María Cristina; Nesse, Alcira; Donato, Hugo

    2017-01-01

    Los objetivos del presente estudio fueron: a) Analizar las características demográficas y clínicas de nuestra población al diagnóstico; b) Evaluar si las pruebas más recientes presentan ventajas sobre las tradicionales; c) Confirmar la frecuencia de las distintas deficiencias de proteínas de membrana; d) Establecer la relación entre severidad y resultado de las pruebas o tipo de deficiencia. Se analizaron 359 individuos estudiados desde 2007, cuando se incorporaron criohemólisis hipertónica (...

  20. Traqueostomía en pediatría: experiencia en un año

    OpenAIRE

    Farina Ruiz, María José; Fajre, Darío Alberto

    2009-01-01

    Este es un trabajo retrospectivo donde se analizaron las indicaciones de traqueostomía en nuestra Unidad de Endoscopía durante el período de febrero de 2007 a febrero de 2008. La población total fue de 21 pacientes. El promedio de edad fue de 26 meses (1-168 meses). La mortalidad relacionada con la traqueostomía fue del 0%. Las indicaciones fueron las siguientes: 1) Obstrucción de la vía aérea alta: 7/21 (33,3%); 2) S...

  1. Experiencia sobre desarrollo con Genexus siguiendo prácticas ágiles

    OpenAIRE

    Gimson Saravia, Loraine Elizabeth; Gil, Gustavo Daniel

    2016-01-01

    Este trabajo busca describir la experiencia realizada con alumnos del último año de la Licenciatura en Análisis de Sistemas de la Universidad Nacional de Salta combinando el desarrollo basado en conocimiento (DBC), utilizando Genexus, con un desarrollo ágil. Se pretendió brindarles una práctica real de aplicar los principios ágiles a los alumnos combinando su aplicación con Genexus a dos proyectos concretos.

  2. Experiencias ecológicas del Colegio de la Inmaculada-Jesuitas

    OpenAIRE

    Carbajal Alva, Max Alberto

    2012-01-01

    This article presents a brief systematization about a pioneer experience of Colegio de la Inmaculada-Jesuitas, a private catholic school located in Lima (Peru) in relation to its environmental projects developed as part of its institutional policy since several decades ago. This experience has deserved public acknowledgement by other Peruvian institutions. El presente artículo plantea una breve sistematización de la experiencia pionera del Colegio de la Inmaculada-Jesuitas, escuela privada...

  3. Experiencias y vivencias en la Ingeniería Clínica

    OpenAIRE

    Saldarriaga, O. D. (Óscar Darío)

    2008-01-01

    Comparto con ustedes las experiencias y vivencias en el desarrollo y evolución en la ingeniería en los hospitales y clínicas, en especial la Ingeniería Clínica (IC). Antes, una breve explicación del desarrollo del Departamento de Ingeniería y Mantenimiento en el Hospital Pablo Tobón Uribe (El Hospital).

  4. Esfuerzos nacionales para la implementación de las sentencias interamericanas: La experiencia mexicana

    Directory of Open Access Journals (Sweden)

    Gladys Fabiola Morales Ramírez

    2015-08-01

    Full Text Available El presente artículo está dedicado al análisis de la experiencia de México en el cumplimiento de sentencias emitidas por la Corte Interamericana de Derechos Humanos, específicamente los esfuerzos de las autoridades nacionales en el diseño de instrumentos especializados para la implementación de estas decisiones.

  5. Gestión del marketing sensorial sobre la experiencia del consumidor

    Directory of Open Access Journals (Sweden)

    Leonardo Ortegón-Cortázar

    2016-01-01

    Full Text Available El rápido desarrollo de mercados con productos competitivos de difícil diferenciación y consumidores mejor informados que demandan experiencias memorables, justifican estudiar los elementos sensoriales que pueden potenciar e influir positivamente sobre dichas experiencias. El objetivo de este artículo es analizar el estado del arte respecto a la gestión y uso del marketing sensorial sobre la experiencia del consumidor. El diseño de investigación es no experimental documental, con un tipo de estudio descriptivo, empleando fuentes de recolección de información secundarias, mediante un arqueo bibliográfico de revistas de impacto que figuran en bases de datos de libre acceso. Los resultados revelan la dominancia del sentido de la visión sobre la persuasión y las actividades de marketing, mientras que el sentido del olfato demuestra mayor influencia sobre el nivel de recuerdo y evocación de información. Se concluye la utilidad de jerarquizar por nivel de influencia las actividades de estimulación sensorial en marketing a partir del funcionamiento y participación de los sentidos humanos y poder combinar dichas estimulaciones como medio para maximizar la experiencia del consumidor y distinguir la oferta de valor, considerando el grado de diferenciación, la favorabilidad y la fuerza de la actividad sensorial basada en planeación estratégica empresarial.

  6. Experiencias, sensaciones y demandas de (inseguridad ciudadana: configuraciones complejas en la Argentina reciente

    Directory of Open Access Journals (Sweden)

    Daniel P. Míguez

    2013-06-01

    Full Text Available En las últimas décadas, el problema de la inseguridad debida al incremento del delito y elposible impacto sobre la estabilidad de las democracias latinoamericanas ha sido objeto dedebate recurrente. En este marco, el presente artículo analiza para el caso argentino la relaciónentre las experiencias y sensaciones de inseguridad, y su vinculación con las demandas derigor punitivo. El análisis se basa en la combinación de dos aproximaciones metodológicas.Inicialmente, se toman datos estadísticos de encuestas internacionales, como Latinobarómetro.Estos son luego comparados con datos revelados mediante la observación participante en unbarrio pobre de una ciudad intermedia de Argentina. La combinación de fuentes alternativaspermite ver la complejidad del proceso. Contrario a lo que muchas veces se ha asumido,no existen vínculos lineales que conduzcan de experiencias y sensaciones de seguridad ademandas de rigor punitivo. La manera en que los actores sociales elaboran sus experienciasde inseguridad es fuertemente situacional y, además, poco sistemática. Hemos encontradoque no necesariamente hay procesos consistentes de ‘construcción de sentido’ que articulenlas sensaciones y experiencias de inseguridad con demandas políticas.

  7. El climaterio y las inmigrantes ecuatorianas: una experiencia natural en manos de otros

    Directory of Open Access Journals (Sweden)

    Juan Manuel Leyva-Moral

    Full Text Available Introducción: El modelo biomédico describe la menopausia como un problema de salud. Los científicos sociales sostienen que se trata de un proceso biológico normal individual cuya experiencia viene determinada por factores culturales. Objetivo: Comprender la experiencia de la menopausia entre las inmigrantes ecuatorianas que viven en Barcelona (España. Diseño: Estudio cualitativo fenomenológico hermenéutico. Trece mujeres ecuatorianas menopáusicas fueron entrevistadas en sus hogares durante el período 2008-2009. Las entrevistas fueron transcritas textualmente y analizadas siguiendo el proceso hermenéutico. Resultados: Cuatro dominios interrelacionados fueron identificados: Una experiencia individual natural, ser mujer, mi sexualidad en manos de otros, ser vs. sentirse mayor. Conclusión: la menopausia entre las inmigrantes ecuatorianas aparece como un evento natural repleto de falsos mitos y tabúes en cuya construcción influyen sustancialmente la biomedicina y el contexto social.

  8. (-)-Epicatechin administration and exercising skeletal muscle vascular control and microvascular oxygenation in healthy rats.

    Science.gov (United States)

    Copp, Steven W; Inagaki, Tadakatsu; White, Michael J; Hirai, Daniel M; Ferguson, Scott K; Holdsworth, Clark T; Sims, Gabrielle E; Poole, David C; Musch, Timothy I

    2013-01-15

    Consumption of the dietary flavanol (-)-epicatechin (EPI) is associated with enhanced endothelial function and augmented skeletal muscle capillarity and mitochondrial volume density. The potential for EPI to improve peripheral vascular function and muscle oxygenation during exercise is unknown. We tested the hypothesis that EPI administration in healthy rats would improve treadmill exercise performance secondary to elevated skeletal muscle blood flow and vascular conductance [VC, blood flow/mean arterial pressure (MAP)] and improved skeletal muscle microvascular oxygenation. Rats received water (control, n = 12) or 4 mg/kg EPI (n = 12) via oral gavage daily for 24 days. Exercise endurance capacity and peak O(2) uptake (Vo(2) peak) were measured via treadmill runs to exhaustion. MAP (arterial catheter) and blood flow (radiolabeled microspheres) were measured and VC was calculated during submaximal treadmill exercise (25 m/min, 5% grade). Spinotrapezius muscle microvascular O(2) pressure (Po(2mv)) was measured (phosphorescence quenching) during electrically induced twitch (1 Hz) contractions. In conscious rats, EPI administration resulted in lower (↓~5%) resting (P = 0.03) and exercising (P = 0.04) MAP. There were no differences in exercise endurance capacity, Vo(2) peak, total exercising hindlimb blood flow (control, 154 ± 13; and EPI, 159 ± 8 ml·min(-1)·100 g(-1), P = 0.68), or VC (control, 1.13 ± 0.10; and EPI, 1.24 ± 0.08 ml·min(-1)·100 g(-1)·mmHg(-1), P = 0.21) between groups. Following anesthesia, EPI resulted in lower MAP (↓~16%) but did not impact resting Po(2mv) or any kinetics parameters (P > 0.05 for all) during muscle contractions compared with control. EPI administration (4 mg·kg(-1)·day(-1)) improved modestly cardiovascular function (i.e., ↓MAP) with no impact on exercise performance, total exercising skeletal muscle blood flow and VC, or contracting muscle microvascular oxygenation in healthy rats.

  9. Comparison between invasive and noninvasive techniques of evaluation of microvascular structural alterations.

    Science.gov (United States)

    De Ciuceis, Carolina; Agabiti Rosei, Claudia; Caletti, Stefano; Trapletti, Valentina; Coschignano, Maria A; Tiberio, Guido A M; Duse, Sarah; Docchio, Franco; Pasinetti, Simone; Zambonardi, Federica; Semeraro, Francesco; Porteri, Enzo; Solaini, Leonardo; Sansoni, Giovanna; Pileri, Paola; Rossini, Claudia; Mittempergher, Francesco; Portolani, Nazario; Ministrini, Silvia; Agabiti-Rosei, Enrico; Rizzoni, Damiano

    2018-05-01

    The evaluation of the morphological characteristics of small resistance arteries in humans is challenging. The gold standard method is generally considered to be the measurement by wire or pressure micromyography of the media-to-lumen ratio of subcutaneous small vessels obtained by local biopsies. However, noninvasive techniques for the evaluation of retinal arterioles were recently proposed; in particular, two approaches, scanning laser Doppler flowmetry (SLDF) and adaptive optics, seem to provide useful information; both of them provide an estimation of the wall-to-lumen ratio (WLR) of retinal arterioles. Moreover, a noninvasive measurement of basal and total capillary density may be obtained by videomicroscopy/capillaroscopy. No direct comparison of these three noninvasive techniques in the same population was previously performed; in particular, adaptive optics was never validated against micromyography. In the current study, we enrolled 41 controls and patients: 12 normotensive lean controls, 12 essential hypertensive lean patients, nine normotensive obese patients and eight hypertensive obese patients undergoing elective surgery. All patients underwent a biopsy of subcutaneous fat during surgery. Subcutaneous small resistance artery structure was assessed by wire micromyography and the media-to-lumen ratio was calculated. WLR of retinal arterioles was obtained by SLDF and adaptive optics. Functional (basal) and structural (total) microvascular density was evaluated by capillaroscopy before and after venous congestion. Our data suggest that adaptive optics has a substantial advantage over SLDF in terms of evaluation of microvascular morphology, as WLR measured with adaptive optics is more closely correlated with the M/L of subcutaneous small arteries (r = 0.84, P < 0.001 vs. r = 0.52, P < 0.05, slopes of the relations: P < 0.01 adaptive optics vs. SLDF). In addition, the reproducibility of the evaluation of the WLR with adaptive optics is

  10. Relación entre el liderazgo directivo con el desempeño docente en las Instituciones Educativas Nuestra Señora de la Merced y Juan XXIII del Nivel Secundario - Cajamarca, 2012

    OpenAIRE

    Chávez Álvarez, Marleni

    2017-01-01

    El presente estudio tuvo como propósito determinar la relación entre el liderazgo directivo con el desempeño docente de las Instituciones Educativas Nuestra Señora de La Merced y Juan XXIII del nivel secundario Cajamarca. El estudio es de tipo Descriptivo-correlacional, cuyo diseño fue no experimental de corte transaccional; pues no se manipuló ninguna de sus variables y se midieron en su contexto natural. La muestra estuvo conformada por 98 docentes, de los cuales: 38 docentes pertenecen a l...

  11. Gestión del potencial humano y liderazgo pedagógico de la Institución Educativa Nuestra Señora de Montserrat, Lima, 2016

    OpenAIRE

    Zeña Crisostomo, Beryi Margarita

    2017-01-01

    La presente investigación titulada, “Gestión del potencial humano y liderazgo pedagógico de la Institución Educativa Nuestra Señora de Montserrat, Lima, 2016”, se propuso como objetivo determinar la relación entre la gestión del potencial humano y el liderazgo pedagógico, ante la problemática de la Institución Educativa referente a los recursos docentes y el ejercicio de su liderazgo. La investigación es de tipo básica y de diseño no experimental, de nivel correlacional de c...

  12. La retinopatía diabética como predictor de morbi-mortalidad cardiovascular en pacientes con diabetes mellitus tipo 2 en un área de 70.000 habitantes de nuestra comunidad

    OpenAIRE

    Blasco Lamarca, Yolanda; Gimeno Orna, José Antonio; Faure Nogueras, Eduardo Jaime

    2013-01-01

    El elevado incremento en la morbi-mortalidad cardiovascular de los pacientes diabéticos, ha planteado la necesidad de búsqueda de marcadores de riesgo vascular. La presencia de retinopatía diabética podría ser un predictor independiente de riesgo de enfermedad cardiovascular. En una muestra de 463 pacientes con diabetes mellitus tipo 2 de nuestra comunidad autónoma hemos evaluado la relación entre la valoración inicial del fondo de ojo y la aparición de eventos cardiovasculares. Tras un seg...

  13. Defensa de lo local en Nuestra América y Coney Island de José Martí: el ensayo como un espacio para la ideología dentro de las raíces hispanoamericanas

    OpenAIRE

    Ángel, Roberto

    2015-01-01

    José Martí proposes that for the proper development of the Republic in America it is essential to secure a government that has as the premises of its administration the natural categories of its origin. To evaluate the local characteristics Martí was thinking of I will carry out an analysis of two of his essays: Nuestra América (Martí, 1977) and Coney Island (Martí, 1881), in an attempt to unravel the polarisation strategy which supports his argument. Indeed, through a semantic axis the autho...

  14. Presence of diabetic microvascular complications does not incrementally increase risk of ischemic stroke in diabetic patients with atrial fibrillation

    Science.gov (United States)

    Chou, Annie Y.; Liu, Chia-Jen; Chao, Tze-Fan; Wang, Kang-Ling; Tuan, Ta-Chuan; Chen, Tzeng-Ji; Chen, Shih-Ann

    2016-01-01

    Abstract Conventional stroke risk prediction tools used in atrial fibrillation (AF) incorporate the presence of diabetes mellitus (DM) as a risk factor. However, it is unknown whether this risk is homogenous or dependent on the presence of diabetic microvascular complications, such as diabetic retinopathy, nephropathy, and neuropathy. The present study examined the risk of ischemic stroke in diabetic patients with and without microvascular complications. The present study used the National Health Insurance Research Database in Taiwan with detailed healthcare data on all-comers to the Taiwanese medical system from January 1, 1996 to December 31, 2011. AF and DM were identified when listed as discharge diagnoses or confirmed more than twice in the outpatient department. Patients on antithrombotic agents were excluded. The clinical endpoint was ischemic stroke. Among the 50,180 AF patients with DM, the majority had no microvascular complications (72.7%), while 2.6% had diabetic retinopathy, 8.4% had diabetic nephropathy, and 16.1% had diabetic neuropathy. Ischemic stroke occurred in 6003 patients, with a 4.74% annual risk of ischemic stroke. When compared with DM patients without microvascular complications, those with diabetic retinopathy, nephropathy, or neuropathy had higher incidences of ischemic stroke (4.65 vs 5.07, 4.77, or 5.20 per 100 person-years, respectively). However, after adjusting for confounding factors, the differences were no longer significant. In a large nationwide AF cohort with DM, risk of ischemic stroke was similar between patients with and without microvascular complications, suggesting that risk stratification of these patients does not require inclusion of diabetic retinopathy, nephropathy, and neuropathy. PMID:27399075

  15. ANAEMIA AS A RISK FACTOR FOR MICROVASCULAR COMPLICATIONS IN TYPE 2 DM- A CROSS-SECTIONAL STUDY

    Directory of Open Access Journals (Sweden)

    Kamanuru Ethirajulu Govindarajulu

    2016-11-01

    Full Text Available BACKGROUND It is well known that diabetes adversely affects the kidneys finally leading to anaemia by various mechanisms. Several studies had postulated that anaemia developing before renal complications has an independent association with microvascular complication in type 2 diabetic patients. The aim of the study is to estimate the prevalence of anaemia in persons with type 2 diabetes mellitus and its role as a risk factor for the presence and the severity of microvascular complication in a populationbased study. MATERIALS AND METHODS This is a cross-sectional study conducted in patients coming to OPD of the Department of General Medicine in Government Vellore Medical College for a duration of 3 months from June 01, 2016, to August 31, 2016. Type 2 DM patients between the age group 20-60 years attending our diabetic clinic of both sex were included in our study. RESULTS From a total of 100 patients, 41% had anaemia including 34% with normochromic normocytic, 65.85% with hyperchromic microcytic anaemia and none of the patient had macrocytic anaemia. Patients who are anaemic had more frequent microvascular complications. There was no significant difference between males and females. The average duration of diabetes has a positive correlation with anaemia. All the microvascular complications like neuropathy, nephropathy and retinopathy had significant association with the presence of anaemia in type 2 patients. Nephropathy had a significant higher frequency compared to others as a complication in type 2 DM. CONCLUSION Our study shows that there is increased prevalence of anaemia in type 2 DM patients and the prevalence of microvascular complications is significantly higher among the diabetic patients with anaemia.

  16. La experiencia vivida de la mujer con enfermedad cardiovascular revascularizada: un estudio de caso

    Directory of Open Access Journals (Sweden)

    Inna Elida Florez Torres

    2016-09-01

    Full Text Available Objetivo: Comprender los significados de la experiencia vivida de una mujer revascularizada por enfermedad coronaria. Metodología: Estudio de caso fenomenológico con perspectiva de género, realizado en Cartagena, Colombia, entre febrero y junio de 2015. El análisis temático estuvo guiado por el método de Van Manen.  Resultados: La experiencia del cuerpo vivido significó percibir el anuncio de la enfermedad, prever los estragos sobre la corporeidad y feminidad, y anticiparse al sufrimiento. Las relaciones vividas significaron mantener un diálogo con un ser superior, una conexión de ayuda y dependencia con los cuidadores, Sentirse “al revés”: de cuidadora a cuidada. La experiencia del espacio vivido significó la entrada al quirófano: Atravesar la raya roja; la estancia en la unidad de cuidado intensivo, recibir un cuidado en soledad; salir de ella, la alegría de ganar una lucha. El tiempo vivido significó un punto de quiebre entre el antes y el ahora, un tránsito temporal de la experiencia, y recuperarse para mantener el rol. Las cosas vividas significaron una preocupación anticipada y una  pérdida del dominio del rol. Conclusión: Los significados otorgados a la experiencia permiten comprender su particularidad existencial. Durante la espera para la cirugía, la mujer se anticipa a los efectos sobre el rol social, sus dinámicas e interacciones; al enfrentarse al procedimiento, vive una situación límite. Intervenciones sensibles al género son requeridas para reconocer las necesidades de la mujer en los diferentes contextos de cuidado.

  17. Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications.

    Science.gov (United States)

    Brannick, Ben; Wynn, Anne; Dagogo-Jack, Samuel

    2016-06-01

    Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. Evidence is increasingly demonstrating that prediabetes is a toxic state, in addition to being a harbinger of future development of diabetes mellitus. This minireview discusses the pathophysiology and clinical significance of prediabetes, and approach to its management, in the context of the worldwide diabetes epidemic. The pathophysiologic defects underlying prediabetes include insulin resistance, β cell dysfunction, increased lipolysis, inflammation, suboptimal incretin effect, and possibly hepatic glucose overproduction. Recent studies have revealed that the long-term complications of diabetes may manifest in some people with prediabetes; these complications include classical microvascular and macrovascular disorders, and our discussion explores the role of glycemia in their development. Finally, landmark intervention studies in prediabetes, including lifestyle modification and pharmacologic treatment, are reviewed. © 2016 by the Society for Experimental Biology and Medicine.

  18. Transit time homogenization in ischemic stroke - A novel biomarker of penumbral microvascular failure?

    DEFF Research Database (Denmark)

    Engedal, Thorbjørn S; Hjort, Niels; Hougaard, Kristina D

    2017-01-01

    Cerebral ischemia causes widespread capillary no-flow in animal studies. The extent of microvascular impairment in human stroke, however, is unclear. We examined how acute intra-voxel transit time characteristics and subsequent recanalization affect tissue outcome on follow-up MRI in a historic...... cohort of 126 acute ischemic stroke patients. Based on perfusion-weighted MRI data, we characterized voxel-wise transit times in terms of their mean transit time (MTT), standard deviation (capillary transit time heterogeneity - CTH), and the CTH:MTT ratio (relative transit time heterogeneity), which...... tissue, prolonged mean transit time (>5 seconds) and very low cerebral blood flow (≤6 mL/100 mL/min) was associated with high risk of infarction, largely independent of recanalization status. In the remaining mismatch region, low relative transit time heterogeneity predicted subsequent infarction...

  19. Retinal Vascular Fractals and Microvascular and Macrovascular Complications in Type 1 Diabetes

    DEFF Research Database (Denmark)

    Grauslund, Jakob; Green, Anders; Kawasaki, Ryo

    2010-01-01

    diabetes. DESIGN: Cross-sectional study. PARTICIPANTS: This was a cross-sectional study of 208 long-term surviving type 1 diabetes patients from a population-based Danish cohort identified in 1973. METHODS: Retinal photographs were obtained at a clinical examination in 2007 or 2008. D(f) was measured......, respectively. Median D(f) was 1.4610 (range, 1.3774-1.5188). After adjustments for age, gender, duration of diabetes, systolic blood pressure, and smoking, persons with lower D(f) were more likely to have proliferative retinopathy (odds ratio [OR], 1.45 per standard deviation [SD] decrease in D(f); 95......PURPOSE: Fractal analysis is a method to quantify the geometric pattern and complexity of the retinal vessels. This study examined the association of retinal fractal dimension (D(f)) and microvascular and macrovascular complications in a population-based cohort of Danish patients with type 1...

  20. Skeletal muscle microvascular and interstitial PO2 from rest to contractions.

    Science.gov (United States)

    Hirai, Daniel M; Craig, Jesse C; Colburn, Trenton D; Eshima, Hiroaki; Kano, Yutaka; Sexton, William L; Musch, Timothy I; Poole, David C

    2018-03-01

    Oxygen pressure gradients across the microvascular walls are essential for oxygen diffusion from blood to tissue cells. At any given flux, the magnitude of these transmural gradients is proportional to the local resistance. The greatest resistance to oxygen transport into skeletal muscle is considered to reside in the short distance between red blood cells and myocytes. Although crucial to oxygen transport, little is known about transmural pressure gradients within skeletal muscle during contractions. We evaluated oxygen pressures within both the skeletal muscle microvascular and interstitial spaces to determine transmural gradients during the rest-contraction transient in anaesthetized rats. The significant transmural gradient observed at rest was sustained during submaximal muscle contractions. Our findings support that the blood-myocyte interface provides substantial resistance to oxygen diffusion at rest and during contractions and suggest that modulations in microvascular haemodynamics and red blood cell distribution constitute primary mechanisms driving increased transmural oxygen flux with contractions. Oxygen pressure (PO2) gradients across the blood-myocyte interface are required for diffusive O 2 transport, thereby supporting oxidative metabolism. The greatest resistance to O 2 flux into skeletal muscle is considered to reside between the erythrocyte surface and adjacent sarcolemma, although this has not been measured during contractions. We tested the hypothesis that O 2 gradients between skeletal muscle microvascular (PO2 mv ) and interstitial (PO2 is ) spaces would be present at rest and maintained or increased during contractions. PO2 mv and PO2 is   were determined via phosphorescence quenching (Oxyphor probes G2 and G4, respectively) in the exposed rat spinotrapezius during the rest-contraction transient (1 Hz, 6 V; n = 8). PO2 mv was higher than PO2 is in all instances from rest (34.9 ± 6.0 versus 15.7 ± 6.4) to contractions (28.4 ± 5

  1. Microvascular pressure responses of second-generation rats chronically exposed to 2 g centrifugation

    Science.gov (United States)

    Richardson, D. R.; Knapp, C. F.

    1977-01-01

    Preliminary results are presented for a study aimed at a quantitative comparison of microvascular dynamics in second-generation rats reared in a 2-g force field produced by centrifugation with similar data from animals reared in a centrifuge that produced only a 1-g force. It is shown that the pressure distribution in the mesenteric microvasculature of the second generation of rats reared in a 2-g environment, as well as the animals' blood pressure response to epinephrine, are significantly different compared to their 1-g counterparts. In particular, 1-g and 2-g chronic centrifugation enhances the arterial blood pressure, and the 2-g force field attenuates the pressor effects of norepinephrine.

  2. [Advances in animal model and traditional Chinese medicine prevention in coronary microvascular dysfunction].

    Science.gov (United States)

    Li, Lei; Liu, Jian-Xun; Ren, Jian-Xun; Guo, Hao; Lin, Cheng-Ren

    2017-01-01

    Coronary microvascular dysfunction (CMD) is a common mechanism for some heart disease like cardiac X syndrome and no-reflow phenomenon after percutaneous coronary intervention(PCI). With the development of medical imageology, CMD has received increased attention. Animal model of CMD is indispensable tool for the research of pathogenesis and treatment evaluation, therefor choose an appropriate animal model is the first issue to carry out CMD research. Experimental and clinical studies have shown unique effectiveness of traditional Chinese medicine(TCM) in CMD therapy. Clarifying of the TCM therapeutic effect mechanisms and seeking an optimal solution of combination of traditional Chinese and western medicine will be the focus of future research. This paper reviewed the establishment and evaluation of CMD animal model, as well as the intervention study of TCM on CMD. The article aims to provide reference for the basic research of CMD and the TCM experimental study on CMD. Copyright© by the Chinese Pharmaceutical Association.

  3. Repeated self-healing of microvascular carbon fibre reinforced polymer composites

    International Nuclear Information System (INIS)

    Coope, T S; Trask, R S; Bond, I P; Wass, D F

    2014-01-01

    A self-healing, high performance, carbon fibre reinforced polymer (CFRP) composite is demonstrated by embedding a Lewis-acid catalytic curing agent within a laminate, manufactured using out of autoclave (OOA) composite manufacturing methods. Two configurations of healing agent delivery, pre-mixed and autonomous mixing, are investigated via injection of a healing agent through bio-inspired microvascular channels exposed on Mode I fractured crack planes. Healing is effected when an epoxy resin-solvent healing agent mixture reaches the boundary of embedded solid-state scandium(III) triflate (Sc(OTf) 3 ) catalyst, located on the crack plane, to initiate the ring-opening polymerisation (ROP) of epoxides. Tailored self-healing agents confer high healing efficiency values after multiple healing cycles (69–108%) to successfully mitigate against crack propagation within the composite microstructure. (paper)

  4. Microvascular disease during pregnancy in type 1 diabetes is associated with ambulatory arterial stiffness

    DEFF Research Database (Denmark)

    Tjessem, Ingvild; Al-Far, Hanine M; Fuglsang, Jens

    2017-01-01

    Objectives: The objective of this study was to evaluate the association between the ambulatory arterial stiffness index (AASI) and markers of microvascular disease during pregnancy in women with type 1 diabetes. Study design: A total of 151 women with type 1 diabetes mellitus were recruited...... during pregnancy in women with type 1 diabetes. Together with the flattened circadian rhythm this indicates a pregnancy-related functional change in the vascular bed....... for repeat 24-h BP recordings thrice during pregnancy and once three months post partum. Fifty women without diabetes served as controls. The AASI and pulse pressure (PP) were computed from blood pressure recordings. Repeated measures analysis of variance was used for comparison between groups during...

  5. Outcomes of microvascular free tissue transfer in twice-irradiated patients.

    Science.gov (United States)

    Clancy, Kate; Melki, Sami; Awan, Musaddiq; Li, Shawn; Lavertu, Pierre; Fowler, Nicole; Yao, Min; Rezaee, Rod; Zender, Chad A

    2017-09-01

    Patients may require microvascular free tissue transfer (MFTT) following re-irradiation for recurrent cancer or radiation complications. The objective of this study was to describe the indications for and outcomes of free flaps performed in twice-radiated patients. A retrospective chart review identified the indications for and outcomes of 36 free flaps performed on 29 twice-irradiated patients. The free flap success rate was 92%. The most common indications requiring MFTT were cancer recurrence and osteoradionecrosis. Sixty-one percent experienced postoperative complications, most commonly wound infection (33%). Twenty-five percent of the procedures required return to the operating room due to postoperative complication. MFTT can be successfully performed in the twice-irradiated patient population with a success rate comparable to singly-radiated patients. Despite a high success rate, there is also a high rate of surgical site complications, especially infection. © 2017 Wiley Periodicals, Inc.

  6. Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications

    Science.gov (United States)

    Brannick, Ben; Wynn, Anne

    2016-01-01

    Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. Evidence is increasingly demonstrating that prediabetes is a toxic state, in addition to being a harbinger of future development of diabetes mellitus. This minireview discusses the pathophysiology and clinical significance of prediabetes, and approach to its management, in the context of the worldwide diabetes epidemic. The pathophysiologic defects underlying prediabetes include insulin resistance, β cell dysfunction, increased lipolysis, inflammation, suboptimal incretin effect, and possibly hepatic glucose overproduction. Recent studies have revealed that the long-term complications of diabetes may manifest in some people with prediabetes; these complications include classical microvascular and macrovascular disorders, and our discussion explores the role of glycemia in their development. Finally, landmark intervention studies in prediabetes, including lifestyle modification and pharmacologic treatment, are reviewed. PMID:27302176

  7. The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation.

    Directory of Open Access Journals (Sweden)

    Julie Wheway

    Full Text Available Endothelial cells (EC form the inner lining of blood vessels and are positioned between circulating lymphocytes and tissues. Hypotheses have formed that EC may act as antigen presenting cells based on the intimate interactions with T cells, which are seen in diseases like multiple sclerosis, cerebral malaria (CM and viral neuropathologies. Here, we investigated how human brain microvascular EC (HBEC interact with and support the proliferation of T cells. We found HBEC to express MHC II, CD40 and ICOSL, key molecules for antigen presentation and co-stimulation and to take up fluorescently labeled antigens via macropinocytosis. In co-cultures, we showed that HBEC support and promote the proliferation of CD4(+ and CD8(+ T cells, which both are key in CM pathogenesis, particularly following T cell receptor activation and co-stimulation. Our findings provide novel evidence that HBEC can trigger T cell activation, thereby providing a novel mechanism for neuroimmunological complications of infectious diseases.

  8. Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications.

    Science.gov (United States)

    Smeets, Ralf; Vorwig, Oliver; Wöltje, Michael; Gaudin, Robert; Luebke, Andreas M; Beck-Broichsitter, Benedicta; Rheinnecker, Michael; Heiland, Max; Grupp, Katharina; Gröbe, Alexander; Hanken, Henning

    2016-05-01

    To evaluate a novel microvascular anastomosis technique using N-fibroin stents. Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate. Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%). Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data

    DEFF Research Database (Denmark)

    Munk, O L; Keiding, S; Bass, L

    2003-01-01

    scanners, little use is made of earlier microvascular research in the compartmental models, which have become the standard model by which the vast majority of dynamic PET data are analysed. However, modern PET scanners provide data with a sufficient temporal resolution and good counting statistics to allow...... single- and multi-capillary systems and include effects of non-exchanging vessels. They are suitable for analysing dynamic PET data from any capillary bed using either intravascular or diffusible tracers, in terms of physiological parameters which include regional blood flow. Udgivelsesdato: 2003-Nov-7......Measurement of exchange of substances between blood and tissue has been a long-lasting challenge to physiologists, and considerable theoretical and experimental accomplishments were achieved before the development of the positron emission tomography (PET). Today, when modeling data from modern PET...

  10. Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study.

    Science.gov (United States)

    Hueper, Katja; Vogel-Claussen, Jens; Parikh, Megha A; Austin, John H M; Bluemke, David A; Carr, James; Choi, Jiwoong; Goldstein, Thomas A; Gomes, Antoinette S; Hoffman, Eric A; Kawut, Steven M; Lima, Joao; Michos, Erin D; Post, Wendy S; Po, Ming Jack; Prince, Martin R; Liu, Kiang; Rabinowitz, Dan; Skrok, Jan; Smith, Ben M; Watson, Karol; Yin, Youbing; Zambeli-Ljepovic, Alan M; Barr, R Graham

    2015-09-01

    Smoking-related microvascular loss causes end-organ damage in the kidneys, heart, and brain. Basic research suggests a similar process in the lungs, but no large studies have assessed pulmonary microvascular blood flow (PMBF) in early chronic lung disease. To investigate whether PMBF is reduced in mild as well as more severe chronic obstructive pulmonary disease (COPD) and emphysema. PMBF was measured using gadolinium-enhanced magnetic resonance imaging (MRI) among smokers with COPD and control subjects age 50 to 79 years without clinical cardiovascular disease. COPD severity was defined by standard criteria. Emphysema on computed tomography (CT) was defined by the percentage of lung regions below -950 Hounsfield units (-950 HU) and by radiologists using a standard protocol. We adjusted for potential confounders, including smoking, oxygenation, and left ventricular cardiac output. Among 144 participants, PMBF was reduced by 30% in mild COPD, by 29% in moderate COPD, and by 52% in severe COPD (all P emphysema-950HU and radiologist-defined emphysema, particularly panlobular and centrilobular emphysema (all P ≤ 0.01). Registration of MRI and CT images revealed that PMBF was reduced in mild COPD in both nonemphysematous and emphysematous lung regions. Associations for PMBF were independent of measures of small airways disease on CT and gas trapping largely because emphysema and small airways disease occurred in different smokers. PMBF was reduced in mild COPD, including in regions of lung without frank emphysema, and may represent a distinct pathological process from small airways disease. PMBF may provide an imaging biomarker for therapeutic strategies targeting the pulmonary microvasculature.

  11. Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells.

    Science.gov (United States)

    Wieghaus, Kristen A; Gianchandani, Erwin P; Neal, Rebekah A; Paige, Mikell A; Brown, Milton L; Papin, Jason A; Botchwey, Edward A

    2009-07-01

    We are creating synthetic pharmaceuticals with angiogenic activity and potential to promote vascular invasion. We previously demonstrated that one of these molecules, phthalimide neovascular factor 1 (PNF1), significantly expands microvascular networks in vivo following sustained release from poly(lactic-co-glycolic acid) (PLAGA) films. In addition, to probe PNF1 mode of action, we recently applied a novel pathway-based compendium analysis to a multi-timepoint, controlled microarray data set of PNF1-treated (vs. control) human microvascular endothelial cells (HMVECs), and we identified induction of tumor necrosis factor-alpha (TNF-alpha) and, subsequently, transforming growth factor-beta (TGF-beta) signaling networks by PNF1. Here we validate this microarray data set with quantitative real-time polymerase chain reaction (RT-PCR) analysis. Subsequently, we probe this data set and identify three specific TGF-beta-induced genes with regulation by PNF1 conserved over multiple timepoints-amyloid beta (A4) precursor protein (APP), early growth response 1 (EGR-1), and matrix metalloproteinase 14 (MMP14 or MT1-MMP)-that are also implicated in angiogenesis. We further focus on MMP14 given its unique role in angiogenesis, and we validate MT1-MMP modulation by PNF1 with an in vitro fluorescence assay that demonstrates the direct effects that PNF1 exerts on functional metalloproteinase activity. We also utilize endothelial cord formation in collagen gels to show that PNF1-induced stimulation of endothelial cord network formation in vitro is in some way MT1-MMP-dependent. Ultimately, this new network analysis of our transcriptional footprint characterizing PNF1 activity 1-48 h post-supplementation in HMVECs coupled with corresponding validating experiments suggests a key set of a few specific targets that are involved in PNF1 mode of action and important for successful promotion of the neovascularization that we have observed by the drug in vivo.

  12. Dorsal column sensory axons degenerate due to impaired microvascular perfusion after spinal cord injury in rats

    Science.gov (United States)

    Muradov, Johongir M.; Ewan, Eric E.; Hagg, Theo

    2013-01-01

    The mechanisms contributing to axon loss after spinal cord injury (SCI) are largely unknown but may involve microvascular loss as we have previously suggested. Here, we used a mild contusive injury (120 kdyn IH impactor) at T9 in rats focusing on ascending primary sensory dorsal column axons, anterogradely traced from the sciatic nerves. The injury caused a rapid and progressive loss of dorsal column microvasculature and oligodendrocytes at the injury site and penumbra and a ~70% loss of the sensory axons, by 24 hours. To model the microvascular loss, focal ischemia of the T9 dorsal columns was achieved via phototoxic activation of intravenously injected rose bengal. This caused an ~53% loss of sensory axons and an ~80% loss of dorsal column oligodendrocytes by 24 hours. Axon loss correlated with the extent and axial length of microvessel and oligodendrocyte loss along the dorsal column. To determine if oligodendrocyte loss contributes to axon loss, the glial toxin ethidium bromide (EB; 0.3 µg/µl) was microinjected into the T9 dorsal columns, and resulted in an ~88% loss of dorsal column oligodendrocytes and an ~56% loss of sensory axons after 72 hours. EB also caused an ~72% loss of microvessels. Lower concentrations of EB resulted in less axon, oligodendrocyte and microvessel loss, which were highly correlated (R2 = 0.81). These data suggest that focal spinal cord ischemia causes both oligodendrocyte and axon degeneration, which are perhaps linked. Importantly, they highlight the need of limiting the penumbral spread of ischemia and oligodendrocyte loss after SCI in order to protect axons. PMID:23978615

  13. The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function.

    Science.gov (United States)

    Ljungman, Petter L; Wilker, Elissa H; Rice, Mary B; Austin, Elena; Schwartz, Joel; Gold, Diane R; Koutrakis, Petros; Benjamin, Emelia J; Vita, Joseph A; Mitchell, Gary F; Vasan, Ramachandran S; Hamburg, Naomi M; Mittleman, Murray A

    2016-03-01

    Prior studies including the Framingham Heart Study have suggested associations between single components of air pollution and vascular function; however, underlying mixtures of air pollution may have distinct associations with vascular function. We used a k-means approach to construct five distinct pollution mixtures from elemental analyses of particle filters, air pollution monitoring data, and meteorology. Exposure was modeled as an interaction between fine particle mass (PM2.5), and concurrent pollution cluster. Outcome variables were two measures of microvascular function in the fingertip in the Framingham Offspring and Third Generation cohorts from 2003 to 2008. In 1,720 participants, associations between PM2.5 and baseline pulse amplitude tonometry differed by air pollution cluster (interaction P value 0.009). Higher PM2.5 on days with low mass concentrations but high proportion of ultrafine particles from traffic was associated with 18% (95% confidence interval: 4.6%, 33%) higher baseline pulse amplitude per 5 μg/m and days with high contributions of oil and wood combustion with 16% (95% confidence interval: 0.2%, 34%) higher baseline pulse amplitude. We observed no variation in associations of PM2.5 with hyperemic response to ischemia observed across air pollution clusters. PM2.5 exposure from air pollution mixtures with large contributions of local ultrafine particles from traffic, heating oil, and wood combustion was associated with higher baseline pulse amplitude but not hyperemic response. Our findings suggest little association between acute exposure to air pollution clusters reflective of select sources and hyperemic response to ischemia, but possible associations with excessive small artery pulsatility with potentially deleterious microvascular consequences.

  14. Endothelial network formed with human dermal microvascular endothelial cells in autologous multicellular skin substitutes.

    Science.gov (United States)

    Ponec, Maria; El Ghalbzouri, Abdoelwaheb; Dijkman, Remco; Kempenaar, Johanna; van der Pluijm, Gabri; Koolwijk, Pieter

    2004-01-01

    A human skin equivalent from a single skin biopsy harboring keratinocytes and melanocytes in the epidermal compartment, and fibroblasts and microvascular dermal endothelial cells in the dermal compartment was developed. The results of the study revealed that the nature of the extracellular matrix of the dermal compartments plays an important role in establishment of endothelial network in vitro. With rat-tail type I collagen matrices only lateral but not vertical expansion of endothelial networks was observed. In contrast, the presence of extracellular matrix of entirely human origin facilitated proper spatial organization of the endothelial network. Namely, when human dermal fibroblasts and microvascular endothelial cells were seeded on the bottom of an inert filter and subsequently epidermal cells were seeded on top of it, fibroblasts produced extracellular matrix throughout which numerous branched tubes were spreading three-dimensionally. Fibroblasts also facilitated the formation of basement membrane at the epidermal/matrix interface. Under all culture conditions, fully differentiated epidermis was formed with numerous melanocytes present in the basal epidermal cell layer. The results of the competitive RT-PCR revealed that both keratinocytes and fibroblasts expressed VEGF-A, -B, -C, aFGF and bFGF mRNA, whereas fibroblasts also expressed VEGF-D mRNA. At protein level, keratinocytes produced 10 times higher amounts of VEGF-A than fibroblasts did. The generation of multicellular skin equivalent from a single human skin biopsy will stimulate further developments for its application in the treatment of full-thickness skin defects. The potential development of biodegradable, biocompatible material suitable for these purposes is a great challenge for future research.

  15. Correlation Factor Analysis of Retinal Microvascular Changes in Patients With Essential Hypertension

    Institute of Scientific and Technical Information of China (English)

    Huang Duru; Huang Zhongning

    2006-01-01

    Objectives To investigate correlation between retinal microvascular signs and essential hypertension classification. Methods The retinal microvascular signs in patients with essential hypertension were assessed with the indirect biomicroscopy lens, the direct and the indirect ophthalmoscopes were used to determine the hypertensive retinopathy grades and retinal arteriosclerosis grades.The rank correlation analysis was used to analysis the correlation these grades with the risk factors concerned with hypertension. Results Of 72 cases with essential hypertension, 28 cases complicated with coronary disease, 20 cases diabetes, 41 cases stroke,17 cases renal malfunction. Varying extent retinal arterioscleroses were found in 71 cases, 1 case with retinal hemorrhage, 2 cases with retina edema, 4 cases with retinal hard exudation, 5 cases with retinal hemorrhage complicated by hard exudation, 2 cases with retinal hemorrhage complicated by hard exudation and cotton wool spot, 1 case with retinal hemorrhage complicated by hard exudation and microaneurysms,1 case with retinal edema and hard exudation, 1 case with retinal microaneurysms, 1 case with branch retinal vein occlusion. The rank correlation analysis showed that either hypertensive retinopathy grades or retinal arteriosclerosis grades were correlated with risk factor lamination of hypertension (r=0.25 or 0.31, P<0.05), other correlation factors included age and blood high density lipoprotein concerned about hypertensive retinopathy grades or retinal arteriosclerosis grades, but other parameters, namely systolic or diastolic pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose,blood urea nitrogen and blood creatinine were not confirmed in this correlation analysis (P > 0.05).Conclusions Either hypertensive retinopathy grade or retinal arteriosclerosis grade is close with the hypertension risk factor lamination, suggesting that the fundus examination of patients with

  16. Omega-3 Polyunsaturated Fatty Acids Enriched Hen Eggs Consumption Enhances Microvascular Reactivity in Young Healthy Individuals.

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    Stupin, Ana; Rasic, Lidija; Matic, Anita; Stupin, Marko; Kralik, Zlata; Kralik, Gordana; Grcevic, Manuela; Drenjancevic, Ines

    2018-04-10

    Whilst the beneficial effect of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on cardiovascular (CV) system is well supported in CV patients, the effect of consumption of omega-3 PUFAs enriched functional food in healthy individuals is still not fully elucidated. This study aimed to determine the effect of consumption of omega-3 PUFAs enriched hen eggs on microvascular reactivity (primary outcome), blood pressure (BP) and serum lipid profile in young healthy individuals. Control group (N=16) ate three ordinary hen eggs (277 mg omega-3 PUFAs/day), and OMEGA-3 group (N=20) ate three omega-3 PUFAs enriched eggs containing 259 mg of omega-3 PUFAs/egg daily (ALA 167 mg/egg, EPA 7 mg/egg, DHA 84 mg/egg) for 3 weeks (777 mg omega-3 PUFAs/day). Post-occlusive reactive hyperemia (PORH) in skin microcirculation assessed by laser Doppler flowmetry, serum lipid profile, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP) and arterial BP were measured in all subjects before and after the protocol. PORH was significantly enhanced, and triglycerides, hsCRP and BP were significantly decreased in OMEGA-3 group compared to baseline measurement, while there was no significant difference in Control group after the protocol compared to baseline. This is the first study to demonstrate that consumption of a mixture of omega-3 PUFAs (ALA+EPA+DHA), provided via enriched hen eggs, elicits changes in microvascular reactivity, BP and triglycerides level in healthy subjects that are associated with CV benefits, thus suggesting that daily consumption of omega-3 PUFAs enriched eggs in healthy individuals may potentially contribute to CV risk factors attenuation and disease prevention.

  17. Microvascular anastomosis using the vascular closure device in free flap reconstructive surgery: A 13-year experience.

    Science.gov (United States)

    Reddy, Chaitan; Pennington, David; Stern, Harvey

    2012-02-01

    The achievement of patency of the microvascular anastomosis in free flap surgery is dependent on a number of factors, central to which is atraumatic handling of the vessel lumen, and intimal apposition. Initial laboratory studies demonstrating the superiority of the non-penetrating vascular closure staple (VCS - Anastoclip ®) were followed by our report in 1999 on a series of free flaps. There is still a paucity of data in the literature on the use of non-penetrating devices for microvascular anastomosis, and our review gives evidence to support the routine use of the VCS in microsurgical free flap surgery. We now report on its successful use over a thirteen year period in 819 free flap reconstructions. Our data indicates the VCS device to be as effective as sutured anastomoses in free tissue transfer surgery. There is also statistically significant data (Barnard's Exact Test) to demonstrate a higher vascular patency rate of the VCS device over sutured anastomoses when sub group analysis is performed. 'Take-back' revision rates were lower amongst flaps that employed VCS use. For arterial anastomoses, this equated to 3/654(0.05%) vs 4/170(2.4%) with hand-sewn anastomoses (p = 0.02). Similarly, for venous anastomoses the 'take-back' revision rate was 7/661(1.1%) vs 8/165(4.8%) with hand-sewn anastomoses (p = 0.003). Furthermore, the major advantage of the VCS is reduction in anastomosis time, from approximately 25 min per anastomosis for sutures to between five and 10 min for staples. Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  18. MicroRNA Signature of Human Microvascular Endothelium Infected with Rickettsia rickettsii

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    Abha Sahni

    2017-07-01

    Full Text Available MicroRNAs (miRNAs mediate gene silencing by destabilization and/or translational repression of target mRNA. Infection of human microvascular endothelial cells as primary targets of Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever, triggers host responses appertaining to alterations in cellular gene expression. Microarray-based profiling of endothelial cells infected with R. rickettsii for 3 or 24 h revealed differential expression of 33 miRNAs, of which miRNAs129-5p, 200a-3p, 297, 200b-3p, and 595 were identified as the top five up-regulated miRNAs (5 to 20-fold, p ≤ 0.01 and miRNAs 301b-3p, 548a-3p, and 377-3p were down-regulated (2 to 3-fold, p ≤ 0.01. Changes in the expression of selected miRNAs were confirmed by q-RT-PCR in both in vitro and in vivo models of infection. As potential targets, expression of genes encoding NOTCH1, SMAD2, SMAD3, RIN2, SOD1, and SOD2 was either positively or negatively regulated. Using a miRNA-specific mimic or inhibitor, NOTCH1 was determined to be a target of miRNA 200a-3p in R. rickettsii-infected human dermal microvascular endothelial cells (HMECs. Predictive interactome mapping suggested the potential for miRNA-mediated modulation of regulatory gene networks underlying important host cell signaling pathways. This first demonstration of altered endothelial miRNA expression provides new insights into regulatory elements governing mechanisms of host responses and pathogenesis during human rickettsial infections.

  19. Erythropoietin promotes network formation of transplanted adipose tissue-derived microvascular fragments

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    P Karschnia

    2018-05-01

    Full Text Available The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF is an emerging pre-vascularisation strategy. Ad-MVF rapidly reassemble into new microvascular networks after in vivo implantation. Herein it was analysed whether this process was improved by erythropoietin (EPO. Ad-MVF were isolated from green fluorescent protein (GFP+ as well as wild-type C57BL/6 mice and cultivated for 24 h in medium supplemented with EPO (20 IU/mL or vehicle. Freshly isolated, non-cultivated ad-MVF served as controls. Protein expression, cell viability and proliferation of ad-MVF were assessed by proteome profiler array and fluorescence microscopy. GFP+ ad-MVF were seeded on collagen-glycosaminoglycan matrices, which were implanted into dorsal skinfold chambers of C57BL/6 mice, to analyse their vascularisation over 14 d by intravital fluorescence microscopy, histology and immunohistochemistry. Cultivation up-regulated the expression of pro- and anti-angiogenic factors within both vehicle- and EPO-treated ad-MVF when compared with non-cultivated controls. Moreover, EPO treatment suppressed cultivation-associated apoptosis and significantly increased the number of proliferating endothelial cells in ad-MVF when compared with vehicle-treated and non-cultivated ad-MVF. Accordingly, implanted matrices seeded with EPO-treated ad-MVF exhibited an improved vascularisation, as indicated by a significantly higher functional microvessel density. The matrices of the three groups contained a comparably large fraction of GFP+ microvessels originating from the ad-MVF, whereas the tissue surrounding the matrices seeded with EPO-treated ad-MVF exhibited a significantly increased microvessel density when compared with the other two groups. These findings indicated that EPO represents a promising cytokine to further boost the excellent vascularisation properties of ad-MVF in tissue-engineering applications.

  20. [Evaluation and Optimization of Microvascular Arterial Anastomoses by Transit Time Flow Measurement].

    Science.gov (United States)

    Herberhold, S; Röttker, J; Bartmann, D; Solbach, A; Keiner, S; Welz, A; Bootz, F; Laffers, W

    2016-03-01

    INDRODUCTION: The regular application of transit time flow measurement in microvascular anastomoses during heart surgery has lead to improvements of the outcome of coronary artery bypass grafts. Our study was meant to discover whether this measurement method was also applicable for evaluation and optimization of microvascular arterial anastomoses of radial forearm flaps. In this prospective examination a combining ultrasound imaging and transit time flow measurement device (VeriQ, MediStim) was used during surgery to assess anastomotic quality of 15 radial forearm flaps. Pulsatility index (PI) and mean blood flow were measured immediately after opening the arterial anastomosis as well as 15 min afterwards. Furthermore, application time and description of handling were recorded seperately for every assessment. Mean blood flow immediately after opening the anastomosis and 15 min later were 3.9 and 3.4 ml/min resepectively showing no statistically significant difference (p=0.96). There was no significance in the increase of pulsatility index from 22.1 to 27.2 (p=0.09) during the same time range, either. Due to measurement results showing atypical pulse curves in 2 cases decision for surgical revision of the anastomoses was made. All forearm flaps showed good vascularisation during follow-up. Time for device set up, probe placement and measurements was about 20 min. Handling was described to be uncomplicated without exception. There were no noteworthy problems. Transit time flow measurement contributes to the improvement of anastomotic quality and therefore to the overall outcome of radial forearm flaps. The examined measurement method provides objective results and is useful for documentation purposes. © Georg Thieme Verlag KG Stuttgart · New York.

  1. Microvascular oxygen extraction during maximal isometric contraction in patients with chronic obstructive pulmonary disease

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    Flavia Fernandes Manfredi de Freitas

    Full Text Available Abstract Introduction: COPD presents decrease in oxidative metabolism with possible losses of cardiovascular adjustments, suggesting slow kinetics microvascular oxygen during intense exercise. Objective: To test the hypothesis that chronic obstructive pulmonary disease (COPD patients have lower muscle performance in physical exercise not dependent on central factors, but also greater muscle oxygen extraction, regardless of muscle mass. Methods: Cross-sectional study with 11 COPD patients and nine healthy subjects, male, paired for age. Spirometry and body composition by DEXA were evaluated. Muscular performance was assessed by maximal voluntary isometric contraction (MVIC in isokinetic dynamometer and muscle oxygen extraction by the NIRS technique. Student t-test and Pearson correlation were applied. A significance level of p<0.05 was adopted. Results: Patients had moderate to severe COPD (FEV1 = 44.5 ± 9.6% predicted; SpO2 = 94.6 ± 1.6%. Lean leg mass was 8.3 ± 0.9 vs. 8.9 ± 1.0 kg (p =0.033, when comparing COPD and control patients, respectively. The decreased muscle oxygen saturation corrected by muscle mass was 53.2% higher (p=0.044 in the COPD group in MVIC-1 and 149.6% higher (p=0.006 in the MVIC-2. Microvascular extraction rate of oxygen corrected by muscle mass and total work was found to be 114.5% higher (p=0.043 in the COPD group in MVIC-1 and 210.5% higher (p=0.015 in the MVIC-2. Conclusion: COPD patients have low muscle performance and high oxygen extraction per muscle mass unit and per unit of work. The high oxygen extraction suggests that quantitative and qualitative mechanisms can be determinants of muscle performance in patients with COPD.

  2. Inhalation exposure to three-dimensional printer emissions stimulates acute hypertension and microvascular dysfunction.

    Science.gov (United States)

    Stefaniak, A B; LeBouf, R F; Duling, M G; Yi, J; Abukabda, A B; McBride, C R; Nurkiewicz, T R

    2017-11-15

    Fused deposition modeling (FDM™), or three-dimensional (3D) printing has become routine in industrial, occupational and domestic environments. We have recently reported that 3D printing emissions (3DPE) are complex mixtures, with a large ultrafine particulate matter component. Additionally, we and others have reported that inhalation of xenobiotic particles in this size range is associated with an array of cardiovascular dysfunctions. Sprague-Dawley rats were exposed to 3DPE aerosols via nose-only exposure for ~3h. Twenty-four hours later, intravital microscopy was performed to assess microvascular function in the spinotrapezius muscle. Endothelium-dependent and -independent arteriolar dilation were stimulated by local microiontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP). At the time of experiments, animals exposed to 3DPE inhalation presented with a mean arterial pressure of 125±4mmHg, and this was significantly higher than that for the sham-control group (94±3mmHg). Consistent with this pressor response in the 3DPE group, was an elevation of ~12% in resting arteriolar tone. Endothelium-dependent arteriolar dilation was significantly impaired after 3DPE inhalation across all iontophoretic ejection currents (0-27±15%, compared to sham-control: 15-120±21%). Endothelium-independent dilation was not affected by 3DPE inhalation. These alterations in peripheral microvascular resistance and reactivity are consistent with elevations in arterial pressure that follow 3DPE inhalation. Future studies must identify the specific toxicants generated by FDM™ that drive this acute pressor response. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Rat muscle microvascular PO2 kinetics during the exercise off-transient.

    Science.gov (United States)

    McDonough, P; Behnke, B J; Kindig, C A; Poole, D C

    2001-05-01

    Dependent upon the relative speed of pulmonary oxygen consumption (VO2) and blood flow (Q) kinetics, the exercise off-transient may represent a condition of sub- or supra-optimal perfusion. To date, there are no direct measurements of the dynamics of the VO2/Q relationship within the muscle at the onset of the work/recovery transition. To address this issue, microvascular PO2 (PO2,m) dynamics were studied in the spinotrapezius muscles of 11 female Sprague-Dawley rats (weight approximately 220 g) during and following electrical stimulation (1 Hz) to assess the adequacy of Q. relative to VO2 post exercise. The exercise blood flow response (radioactive microspheres: muscle Q increased approximately 240 %), and post-exercise arterial blood pH (7.40 +/- 0.02) and blood lactate (1.3 +/- 0.4 mM x l(-1)) values were consistent with moderate-intensity exercise. Recovery PO2,m (i.e. off-transient) rose progressively until baseline values were achieved ((Delta)end-recovery exercise PO2,m, 14.0 +/- 1.9 Torr) and at no time fell below exercising PO2,m. The off-transient PO2,m was well fitted by a dual exponential model with both fast (tau = 25.4 +/- 5.1 s) and slow (tau = 71.2 +/- 34.2 s) components. Furthermore, there was a pronounced delay (54.9 +/- 10.7 s) before the onset of the slow component. These data, obtained at the muscle microvascular level, support the notion that muscle VO2 falls with faster kinetics than muscle Q during the off-transient, such that PO2,m increases systematically, though biphasically, during recovery.

  4. Reduced toxicity polyester resins and microvascular pre-preg tapes for advanced composites manufacturing

    Science.gov (United States)

    Poillucci, Richard

    Advanced composites manufacturing broadly encapsulates topics ranging from matrix chemistries to automated machines that lay-up fiber-reinforced materials. Environmental regulations are stimulating research to reduce matrix resin formulation toxicity. At present, composites fabricated with polyester resins expose workers to the risk of contact with and inhalation of styrene monomer, which is a potential carcinogen, neurotoxin, and respiratory irritant. The first primary goal of this thesis is to reduce the toxicity associated with polyester resins by: (1) identification of potential monomers to replace styrene, (2) determination of monomer solubility within the polyester, and (3) investigation of approaches to rapidly screen a large resin composition parameter space. Monomers are identified based on their ability to react with polyester and their toxicity as determined by the Globally Harmonized System (GHS) and a green screen method. Solubilities were determined by the Hoftyzer -- Van Krevelen method, Hansen solubility parameter database, and experimental mixing of monomers. A combinatorial microfluidic mixing device is designed and tested to obtain distinct resin compositions from two input chemistries. The push for safer materials is complemented by a thrust for multifunctional composites. The second primary goal of this thesis is to design and implement the manufacture of sacrificial fiber materials suitable for use in automated fiber placement of microvascaular multifunctional composites. Two key advancements are required to achieve this goal: (1) development of a roll-to-roll method to place sacrificial fibers onto carbon fiber pre-preg tape; and (2) demonstration of feasible manufacture of microvascular carbon fiber plates with automated fiber placement. An automated method for placing sacrificial fibers onto carbon fiber tapes is designed and a prototype implemented. Carbon fiber tows with manual placement of sacrificial fibers is implemented within an

  5. Acute Cutaneous Microvascular Flow Responses to Whole-Body Tilting in Humans

    Science.gov (United States)

    Breit, Gregory A.; Watenpaugh, Donald E.; Ballard, Richard E.; Hargens, Alan R.

    1993-01-01

    The transition from upright to head-down tilt (HDT) posture in humans increases blood pressure superior to the heart and decreases pressure inferior to the heart. Consequently, above heart level, myogenic arteriolar tone probably increases with HDT, in opposition to the withdrawal of baroreceptor-mediated sympathetic tone. We hypothesized that due to antagonism between central and local controls, the response of the facial cutaneous microcirculation to acute postural change will be weaker than that in the leg, where these two mechanisms reinforce each other. Cutaneous microvascular flow was measured by laser Doppler flowmetry simultaneously at the shin and the neck of 7 male and 3 female subjects. Subjects underwent a stepwise tilt protocol from standing control to 54 deg head-up tilt (HUT), 30 deg, 12 deg, O deg, -6 deg (HDT), -12 deg, -6 deg, O deg, 12 deg, 30 deg, 54 deg, and standing, for 30-sec periods with 10-sec transitions between postures. Flows at the shin and the neck increased significantly (P less than 0.05) from standing baseline to 12 deg HUT (252 +/- 55 and 126 +/- 9% (bar X +/- SE) of baseline, respectively). From 12 deg to -12 deg tilt, flows continued to increase at the shin (509 +/- 71% of baseline) but decreased at the neck to baseline levels (100 +/- 15% of baseline). Cutaneous microvascular flow recovered at both sites during the return to standing posture with significant hysteresis. Flow increases from standing to near-supine posture are attributed at both sites to baroreceptor-mediated vasodilation. The great dissimilarity in flow response magnitudes at the two measurement sites may be indicative of central/local regulatory antagonism above heart level and reinforcement below heart level.

  6. Effect of thrombus composition and viscosity on sonoreperfusion efficacy in a model of microvascular obstruction

    Science.gov (United States)

    Black, John J.; Yu, Francois T. H.; Schnatz, Rick G.; Flordeliza, Xucai Chen; Villanueva, S.; Pacella, John J.

    2016-01-01

    Distal embolization of microthrombi during stenting for myocardial infarction (MI) causes microvascular obstruction (MVO). We have previously shown that sonoreperfusion (SRP), a microbubble (MB)-mediated ultrasonic (US) therapy, resolves MVO from venous microthrombi in vitro in saline. However, blood is more viscous than saline and arterial thrombi that embolize during stenting are mechanically distinct from venous clot. Therefore, we tested the hypothesis that MVO created with arterial microthrombi are more resistant to SRP therapy compared with venous microthrombi and higher viscosity further increases the US requirement for effective SRP in an in vitro model of MVO. Lipid MB suspended in plasma with adjusted viscosity (1.1 or 4.0 cP) were passed through tubing bearing a mesh with 40 μm pores to simulate a microvascular cross-section; upstream pressure reflected thrombus burden. To simulate MVO, the mesh was occluded with either arterial or venous microthrombi to increase upstream pressure to 40±5 mmHg. Therapeutic long-tone-burst US was delivered to the occluded area for 20 min. MB activity was recorded with a passive cavitation detector (PCD). MVO caused by arterial microthrombi at either blood or plasma viscosity resulted in less effective SRP therapy, compared to venous thrombi. Higher viscosity further reduced the effectiveness of SRP therapy. PCD showed a decrease in inertial cavitation when viscosity was increased while stable cavitation was affected in a more complex manner. Overall, these data suggest that arterial thrombi may require higher acoustic pressure US than venous thrombi to achieve similar SRP efficacy, increased viscosity decreases SRP efficacy, and both inertial and stable cavitation are implicated in observed SRP efficacy. PMID:27207018

  7. Encouraging effects of a short-term, adapted Nordic diet intervention on skin microvascular function and skin oxygen tension in younger and older adults.

    Science.gov (United States)

    Rogerson, David; McNeill, Scott; Könönen, Heidi; Klonizakis, Markos

    2018-05-01

    The microvascular benefits of regional diets appear in the literature; however, little is known about Nordic-type diets. We investigated the effects of a short-term, adapted, Nordic diet on microvascular function in younger and older individuals at rest and during activity. Thirteen young (mean age: 28 y; standard deviation: 5 y) and 15 older (mean age: 68 y; standard deviation: 6 y) participants consumed a modified Nordic diet for 4 wk. Laser Doppler flowmetry and transcutaneous oxygen monitoring were used to assess cutaneous microvascular function and oxygen tension pre- and postintervention; blood pressure, body mass, body fat percentage, ratings of perceived exertion, and peak heart rate during activity were examined concurrently. Axon-mediated vasodilation improved in older participants (1.17 [0.30] to 1.30 [0.30]; P Nordic diet might improve microvascular health. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Experiencias de vida económica y desarrollo humano de estudiantes universitarios de otras localidades en Barranquilla (Colombia

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    Mayilin Moreno Torres

    2004-01-01

    Full Text Available Esta investigación se propuso indagar si las experiencias económicas vividas en Barranquilla (Colombia por estudiantes universitarios provenientes de otras localidades favorecían su desarrollo humano. Para llevarla a cabo se utilizó un método cualitativo con orientación interpretativa. Los resultados mostraron que las experiencias económicas sí contribuyen notablemente a la construcción de desarrollo humano porque logran tener mucho significado en la vida de estos estudiantes. Es decir, a medida que viven estas experiencias, las decisiones de su vida van teniendo un solo y auténtico sujeto: él mismo. En consecuencia, lo que se impone es su libertad, su autonomía. Estas experiencias económicas, por tanto, no sólo le permiten tomar distancia de sus propios impulsos sino también de la tradición. Ello configura una experiencia de progreso, de ilustración, de modernidad.

  9. Doação de órgãos e tecidos: relação com o corpo em nossa sociedade Donación de órganos y tejidos: relación con el cuerpo en nuestra sociedad Organ and tissues donation: relation with the body in our society

    Directory of Open Access Journals (Sweden)

    Bartira De Aguiar Roza

    2010-06-01

    Full Text Available Este estudo, de revisão bibliográfica, objetivou tecer considerações teóricas sobre doação de órgãos e tecidos e sua relação com o corpo em nossa sociedade. O aumento da taxa de doação depende de um olhar ampliado além das questões técnicas do processo de doação de órgãos e tecidos. Vários países, com larga experiência temporal e, que trabalham sistematicamente nesse processo, incorporaram a abordagem social e a perspectiva ética, baseadas no voluntarismo das famílias e no respeito ao direito de autonomia dos potenciais doadores. O acompanhamento do corpo, pós-doação, solicitado pelas famílias, representa o início do luto pela morte de um parente, parte da prática de ritual fúnebre cultuada em nossa sociedade. As ações que asseguram uma sequência ético-legal, definida na legislação dos transplantes, pressupõem compromisso com a qualidade e segurança do processo de doação de órgãos e tecidos, que deve ser rigorosamente perseguida pelos profissionais que trabalham na área. Espera-se, assim, que essas atitudes construam uma cultura positiva sobre a doação no país, contribuindo, a longo prazo, para o aumento nas taxas de doação.Se trata de un estudio de revisión de literatura dirigida a elaborar consideraciones teóricas sobre la donación de órganos y tejidos y su relación con el cuerpo en nuestra sociedad. El aumento de la tasa de donación depende de una visión que va más allá de las cuestiones técnicas en el proceso de la donación de órganos y tejidos. Varios países con gran tiempo de experiencia, trabajando sistemáticamente en este proceso con un enfoque que incorpora el punto de vista social y ético, basado en voluntarios y respetando en las familias el derecho a la autonomía de los posibles donantes. El acompañamiento del cuerpo, después de la donación, generalmente solicitado por la familia, representa el comienzo del luto por la muerte de un pariente, lo que hace parte del

  10. Experiencias formativas, auto-adscripciones y conflictos ambientales en el sudoeste de Misiones (Argentina

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    Ana Padawer

    2015-04-01

    Full Text Available En este artículo abordaremos cómo se relacionan las experiencias formativas vinculadas al trabajo rural, las identificaciones y los conflictos ambientales en San Ignacio, Misiones (Argentina. Nos interesa problematizar cómo los aprendizajes ligados a las tareas rurales se vinculan con las auto-adscripciones de los sujetos, teniendo como referencia las categorías de actores sociales agrarios regionales y las denominaciones que provienen de agendas estatales de intervención. Estos procesos acontecen en un contexto de creciente concentración de propiedades que se destinan a la explotación forestal, donde observamos, en algunos casos, cierta ambientalización de los históricos conflictos territoriales.Utilizando materiales provenientes de un trabajo de campo etnográfico que iniciamos en 2008, presentaremos a dos familias de pobladores rurales. En ambos casos es posible ver cómo el acceso a la tierra es decisivo para las experiencias formativas en las actividades de reproducción social, y que se liga con identificaciones como “gente de la colonia” y una incipiente referencia a la “agricultura familiar” a partir de las intervenciones del Estado. Estas dos familias permiten mostrar cómo las experiencias e identificaciones se expresan en el contexto de la participación de los sujetos en conflictos sociales, que asumen en un caso la forma histórica de reclamos fundiarios mientras que, en el otro, es posible ver que el ambiente tiene protagonismo incipiente.

  11. LO QUE EL OJO NO VE: ANÁLISIS DE UNA EXPERIENCIA

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    J.A. García-García

    2010-09-01

    Full Text Available Durante diez meses hemos realizado una actividad-exposición en el Parque de las Ciencias de Granada. En el espacio “Ventana a la Ciencia” la exposición “Lo que el ojo no ve” ha pretendido mostrar a la ciudadanía aspectos de la Óptica relacionados conlos límites de la visión humana y los avances científicos que han permitido superar dichos límites. Ha sido una actividad didáctica, divulgativa e interactiva, que ha buscado fomentar la reflexión del visitante.El objetivo fundamental de este trabajo es analizar dicha experiencia, planteándonos si experiencias como ésta contribuyen a fomentar la cultura científica de la ciudadanía. Para realizar la evaluación de la misma se ha aplicado una encuesta a una muestra de los visitantes cuyos resultados muestran que más del 90% consideraque ha aprendido de ella, al tiempo que la valoran como divertida. Así mismo, al pedírseles que la calificaran, lo han hecho con una nota media de 9 sobre 10. Por la experiencia vivida y por los resultados obtenidos, consideramos que actividades como ésta resultan de interés y debieran potenciarse como una vía válida para la divulgación científica.

  12. Inmigrantes colombianos en España. Experiencia parental e inmigración

    Directory of Open Access Journals (Sweden)

    Amparo Micolta León

    2007-01-01

    Full Text Available La parentalidad es una posición dentro de la estructura social, definida por un conjunto de expectativas y tareas socialmente construidas. Son tareas del padre y de la madre atender a los requerimientos tanto afectivos como biológicos de la crianza, el cuidado y la educación de los hijos e hijas. Cuando el padre o la madre –o ambos– emigran hacia otro país pueden dejar a sus hijos e hijas en el país de origen bajo la atención de otros adultos, o llevarlos al lugar de destino. En el presente artículo se analizan las experiencias de colombianos y colombianas que eligieron la segunda opción. En un proceso migratorio internacional se viven nuevas experiencias que pueden llevar a momentos críticos en el desempeño de los roles parentales; porque emigrar hacia el exterior implica, entre otras significaciones, establecerse en un territorio desconocido, y realizar y anticipar funciones novedosas. Padres y madres construyen sueños y esperanzas asociados a la búsqueda de un futuro mejor para sí mismos, para sus hijos e hijas y para su grupo familiar. En el nuevo lugar de residencia, hombres y mujeres, ante la ausencia de redes de apoyo familiar, generan alternativas para asumir la responsabilidad total de sus niñas y niños. En este escrito se analiza lo narrado por los y las informantes, pretendiendo dar respuesta a los siguientes interrogantes: ¿Cuáles fueron las razones que motivaron a los padres y a las madres a llevar a sus hijos a España? ¿Cuáles son sus experiencias frente al desempeño como padres o como madres? ¿Qué expectativas tienen para el futuro de sus hijos e hijas?

  13. Inmigrantes colombianos en España. Experiencia parental e inmigración

    Directory of Open Access Journals (Sweden)

    Amparo Micolta León

    2007-05-01

    Full Text Available La parentalidad es una posición dentro de la estructura social, definida por un conjunto de expectativas y tareas socialmente construidas. Son tareas del padre y de la madre atender a los requerimientos tanto afectivos como biológicos de la crianza, el cuidado y la educación de los hijos e hijas. Cuando el padre o la madre –o ambos– emigran hacia otro país pueden dejar a sus hijos e hijas en el país de origen bajo la atención de otros adultos, o llevarlos al lugar de destino. En el presente artículo se analizan las experiencias de colombianos y colombianas que eligieron la segunda opción.En un proceso migratorio internacional se viven nuevas experiencias que pueden llevar a momentos críticos en el desempeño de los roles parentales; porque emigrar hacia el exterior implica, entre otras significaciones, establecerse en un territorio desconocido, y realizar y anticipar funciones novedosas. Padres y madres construyen sueños y esperanzas asociados a la búsqueda de un futuro mejor para sí mismos, para sus hijos e hijas y para su grupo familiar. En el nuevo lugar de residencia, hombres y mujeres, ante la ausencia de redes de apoyo familiar, generan alternativas para asumir la responsabilidad total de sus niñas y niños. En este escrito se analiza lo narrado por los y las informantes, pretendiendo dar respuesta a los siguientes interrogantes: ¿Cuáles fueron las razones que motivaron a los padres y a las madres a llevar a sus hijos a España? ¿Cuáles son sus experiencias frente al desempeño como padres o como madres? ¿Qué expectativas tienen para el futuro de sus hijos e hijas?

  14. Pisada como trapo de piso: experiencia de violencia hospitalaria en el Nordeste Brasileño

    Directory of Open Access Journals (Sweden)

    Annatália Meneses de Amorim GOMES

    2010-12-01

    Full Text Available A pesar de los recientes esfuerzos para mejorar la calidad de los servicios públicos de salud en el Brasil, iniquidades y violencia institucional persisten en los hospitales. Este estudio antropológico-crítico investiga la experiencia humana de hospitalización del punto de vista del paciente internado en un hospital público, localizado en Fortaleza (Ceará, nordeste brasileño. Un método cualitativo original, “El camino del paciente” fue creado y utilizado, mezclando entrevista etnográfica, narrativa del paciente realizada prospectivamente durante la internación, desde la llegada al hospital hasta el alta, y observación-participante de 13 informantesclaves. Los resultados rebelaran 225 experiencias distintas de hospitalización narrada por los pacientes. La mayoría (83,6% de los hechos fue interpretada como “desprecio” y “humillación”; sólo 16,4% fueron percibidos como “cuidado” por el paciente, contribuyendo para la recuperación de su salud. Mostraron la desmoralización progresiva del “paciente sospechoso” desde la recepción por un guardia uniformado hasta la apropiación de sus pertenencias personales. La hospitalización se caracteriza por abandono, soledad y prisión, por la imposición de normas, reglas y procedimientos que ignoran la autonomía, condiciones personales y subjetividad del paciente. A pesar de la estructura opresiva, los pacientes resisten a las agresiones, utilizando múltiples estrategias: trazos personales, imaginación creativa, solidaridad social y fe religiosa. Humanizar la hospitalización pública en el Nordeste brasileño requiere incluir la voz y la experiencia del paciente, desechando los estigmas que perjudican.

  15. Sobre la desnaturalización de la experiencia escolar: aportes decoloniales y feministas

    Directory of Open Access Journals (Sweden)

    Ana de Anquín

    2015-04-01

    Full Text Available La huella formativa de la experiencia escolar es indeleble, aunque la memoria parezca olvidarla se hace cuerpo y atraviesa contextos y situaciones hasta re-encontrarnos comodocentes. En parte forjados como tales, nuestro material de trabajo son los conocimientos,más o menos delimitados en currículos, programas o planes de estudios en cada país. Perotanto el conocimiento como la escuela y el estado nacional se inscriben en estructuras más amplias de relaciones coloniales entre centros y periferias. Los estudios decoloniales investigan la pervivencia de categorías coloniales modernas que subordinan pensamientos yprácticas a la lógica del conquistador: hombre, blanco, heterosexual, burgués. La lógica dicotómica del iluminismo moderno, que propagó la dominación capitalista, opera como violencia simbólica que divide y jerarquiza la experiencia escolar y la vida. Por lo contrario, desde una lógica interseccional se articulan distintas dimensiones como raza, clase, sexualidad y género, en un acto de pensamiento capaz de desnaturalizar clasificaciones homogéneas y extrañas. Así, el constructo ficcional “raza” tiene vigencia en una forma heredada de pensarnos a nosotros mismos, minusvalorados desde el patrón europeo (Quijano,2000. Tratamos de abrir paso a una transversalidad alternativa, considerando que las prácticas educativas son producciones históricas y la pedagogía no es un resultado a alcanzar sino posibilidad de experiencias.

  16. Examen de post-efecto para experiencias anómalo/ paranormales con un abordaje humanista

    Directory of Open Access Journals (Sweden)

    Alejandro Parra

    2014-07-01

    Full Text Available Se presentan los resultados de una investigación que tuvo como objetivos: explorar la utilidad de la terapia grupal para hacer frente a los efectos de las experiencias paranormales y explorar cómo la terapia humanista produce cambios positivos hacia las experiencias anómalo/paranormales. Se les pidió a la muestra (N= 20, rango 22-71 años, M= 45,65, DT= 12,52, 65 % mujeres y 35 % varones, responder un cuestionario autoadministrado de siete preguntas antes y al finalizar su participación en un grupo. La actividad incluyó tres fases: (1 Exposición, (2 Interpretación y (3 Cierre del grupo. Los participantes indicaron que el grupo ayudó a disminuir su malestar emocional (p = ,001, y lograr una comprensión a sus experiencias (p = ,008. Abstract This article shows the results of an investigation aimed to: explore the usefulness of group therapy to deal with the effects of paranormal experiences and explore how humanistic therapy produces positive changes to the anomalous/paranormal experiences. They were asked to sample (N = 20, range 22-71 years, M = 45.65, SD = 12.52, 65 % female and 35 % male, a self-administered questionnaire to answer seven questions before and after your participation in a group. The activity included three phases: (1 Exposure (2 Interpretation y (3 Close the group. Participants indicated that the group helped reduce their emotional distress (p = .001, and gain an understanding of their experiences (p = .008.

  17. Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease

    DEFF Research Database (Denmark)

    Jürs, Anders; Pedersen, Lene Rørholm; Olsen, Rasmus Huan

    2015-01-01

    BACKGROUND: Coronary artery disease (CAD) has a negative impact on exercise capacity. The aim of this study was to determine how coronary microvascular function, glucose metabolism and body composition contribute to exercise capacity in overweight patients with CAD and without diabetes. METHODS...... by a cardiopulmonary exercise test. Body composition was determined by whole body dual-energy X-ray absorptiometry scan and magnetic resonance imaging. Coronary flow reserve (CFR) assessed by transthoracic Doppler echocardiography was used as a measure of microvascular function. RESULTS: Median BMI was 31.3 and 72...... metabolism and body composition. CFR, EDV and LVEF remained independent predictors of VO2peak in multivariable regression analysis. CONCLUSION: The study established CFR, EDV and LVEF as independent predictors of VO2peak in overweight CAD patients with no or only mild functional symptoms and a LVEF > 35...

  18. [Low-dose aspirin in patients with diabete melitus: risks and benefits regarding macro and microvascular complications].

    Science.gov (United States)

    Camargo, Eduardo G; Gross, Jorge Luiz; Weinert, Letícia S; Lavinsky, Joel; Silveiro, Sandra P

    2007-04-01

    Aspirin is recommended as cardiovascular disease prevention in patients with diabetes mellitus. Due to the increased risk of bleeding and because of the hypothesis that there could be a worsening of microvascular complications related to aspirin, there has been observed an important underutilization of the drug. However, it is now known that aspirin is not associated with a deleterious effect on diabetic retinopathy and there is evidence indicating that it also does not affect renal function with usual doses (150 mg/d). On the other hand, higher doses may prove necessary, since recent data suggest that diabetic patients present the so called "aspirin resistance". The mechanisms of this resistance are not yet fully understood, being probably related to an abnormal intrinsic platelet activity. The employment of alternative antiplatelet strategies or the administration of higher aspirin doses (150-300 mg/d) should be better evaluated regarding effective cardiovascular disease prevention in diabetes as well as the possible effects on microvascular complications.

  19. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography.

    Science.gov (United States)

    Gagnon, Louis; Sakadžić, Sava; Lesage, Fréderic; Mandeville, Emiri T; Fang, Qianqian; Yaseen, Mohammad A; Boas, David A

    2015-01-01

    Computing microvascular cerebral blood flow ([Formula: see text]) in real cortical angiograms is challenging. Here, we investigated whether the use of Doppler optical coherence tomography (DOCT) flow measurements in individual vessel segments can help in reconstructing [Formula: see text] across the entire vasculature of a truncated cortical angiogram. A [Formula: see text] computational framework integrating DOCT measurements is presented. Simulations performed on a synthetic angiogram showed that the addition of DOCT measurements, especially close to large inflowing or outflowing vessels, reduces the impact of pressure boundary conditions and estimated vessel resistances resulting in a more accurate reconstruction of [Formula: see text]. Our technique was then applied to reconstruct microvascular flow distributions in the mouse cortex down to [Formula: see text] by combining two-photon laser scanning microscopy angiography with DOCT.

  20. Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers

    DEFF Research Database (Denmark)

    Munk, O L; Bass, L; Feng, H

    2003-01-01

    Today, the standard approach for the kinetic analysis of dynamic PET studies is compartment models, in which the tracer and its metabolites are confined to a few well-mixed compartments. We examine whether the standard model is suitable for modern PET data or whether theories including more...... physiologic realism can advance the interpretation of dynamic PET data. A more detailed microvascular theory is developed for intravascular tracers in single-capillary and multiple-capillary systems. The microvascular models, which account for concentration gradients in capillaries, are validated and compared...... with the standard model in a pig liver study. METHODS: Eight pigs underwent a 5-min dynamic PET study after (15)O-carbon monoxide inhalation. Throughout each experiment, hepatic arterial blood and portal venous blood were sampled, and flow was measured with transit-time flow meters. The hepatic dual...