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Sample records for micrornas nova classe

  1. Fermi Establishes Classical Novae as a Distinct Class of Gamma-ray Sources

    Science.gov (United States)

    Ackermann, M.; Ajello, M.; Albert, A.; Baldini, L.; Ballet, J.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caragiulo, M.; Caraveo, P. A.; Ferrara, E. C.; Harding, A. K.; Hays, E.; Perkins, J. S.; Thompson, D. J.

    2014-01-01

    A classical nova results from runaway thermonuclear explosions on the surface of a white dwarf that accretes matter from a low-mass main-sequence stellar companion. In 2012 and 2013, three novae were detected in gamma rays and stood in contrast to the first gamma-ray detected nova V407 Cygni 2010, which belongs to a rare class of symbiotic binary systems. Despite likely differences in the compositions and masses of their white dwarf progenitors, the three classical novae are similarly characterized as soft spectrum transient gamma-ray sources detected over 2-3 week durations. The gamma-ray detections point to unexpected high-energy particle acceleration processes linked to the mass ejection from thermonuclear explosions in an unanticipated class of Galactic gamma-ray sources.

  2. Exercício físico e microRNAs: novas fronteiras na insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Miguel Morita Fernandes-Silva

    2012-05-01

    Full Text Available Embora recentemente tenha sido questionado o impacto do exercício na sobrevida de pacientes com insuficiência cardíaca, o treinamento físico melhora a qualidade de vida, a capacidade funcional, a inflamação, a função autonômica e a função endotelial. Nos últimos anos, vem crescendo o interesse em um grupo de pequenos RNAs não codificadores de proteína chamados microRNAs. Estudos têm demonstrado que a expressão dessas moléculas se modifica em diversas condições patológicas, como a hipertrofia miocárdica, a isquemia miocárdica e a insuficiência cardíaca, e, quando ocorre melhora clínica, elas parecem se normalizar. Com o potencial de aplicabilidade prática, já foram identificados marcadores que poderão ser úteis na avaliação diagnóstica e prognóstica da insuficiência cardíaca, como o miR-423-5p. Além disso, resultados de estudos experimentais indicam haver possíveis efeitos terapêuticos dos microRNAs. Implicados na regulação da expressão genética durante o desenvolvimento fetal e no indivíduo adulto, os microRNAs aumentam ou diminuem no coração em resposta a estresse fisiológico, injúria ou sobrecarga hemodinâmica. Assim, o estudo do comportamento dessas moléculas no exercício físico vem trazendo informações importantes quanto aos efeitos dessa modalidade terapêutica e representa uma nova era no entendimento da insuficiência cardíaca. Esta revisão tem por objetivo integrar as evidências sobre microRNAs na insuficiência cardíaca com maior relevância no estudo do exercício físico.

  3. A "nova classe média": repercussões psicossociais em famílias brasileiras

    Directory of Open Access Journals (Sweden)

    Luís Fernando de Oliveira Saraiva

    2015-04-01

    Full Text Available O presente artigo, em uma abordagem ensaística, tem como objetivo analisar efeitos psicossociais na constituição de modos de subjetivação e em famílias a partir da emergência daquilo que vem sendo nomeado de a "nova classe média brasileira". Para isto, primeiramente foi feita revisão bibliográfica de como a sociologia, economia e antropologia vem conceituando e caracterizando esta nova classe social, considerando que não há estudos acerca desse tema na Psicologia. A partir do diálogo com fontes midiáticas, buscou-se pensar como vem sendo operada a construção de um "estilo de vida" marcado pela tentativa de planejamento do futuro, consumo e meritocracia. Tais características mostram-se importantes formas de aproximação com a classe média tradicional. Por fim, buscou-se entender como famílias vêm vivenciando tais mudanças em seu cotidiano, organização e relações.

  4. Uma nova classe média no Brasil da última década?: o debate a partir da perspectiva sociológica

    Directory of Open Access Journals (Sweden)

    Celi Scalon

    2012-08-01

    Full Text Available Este artigo analisa o surgimento de uma nova classe média, como vem sendo proposto pelos economistas brasileiros, à luz da perspectiva sociológica dos Estudos de Classe. Para tanto, recupera o debate da Economia, que se baseia na renda para definir classes, assim como o da Sociologia da Estratificação, de acordo com seus diferentes marcos teóricos. Usando dados das PNADs 2002 e 2009, apresenta o argumento de que as mudanças na estrutura de classes não foram significativas a ponto de apoiar a ideia de uma nova classe, nem houve um crescimento na classe média tradicional.The article analyses, from the perspective of class studies in Sociology, the argument of Brazilian economists about the emergence of a new middle class. To achieve this task, the paper brings the debate conducted in economics, in which class is defined by income, as well as the debate of the Sociology of Stratification, according to its different theoretical frameworks. Using data from PNADs 2002 and 2009, it argues that the changes in the classes structure were not significant to support the idea of existence of a new class, neither that there was a growth in the traditional middle class.

  5. Improving classification of mature microRNA by solving class imbalance problem

    Science.gov (United States)

    Wang, Ying; Li, Xiaoye; Tao, Bairui

    2016-05-01

    MicroRNAs (miRNAs) are ~20–25 nucleotides non-coding RNAs, which regulated gene expression in the post-transcriptional level. The accurate rate of identifying the start sit of mature miRNA from a given pre-miRNA remains lower. It is noting that the mature miRNA prediction is a class-imbalanced problem which also leads to the unsatisfactory performance of these methods. We improved the prediction accuracy of classifier using balanced datasets and presented MatFind which is used for identifying 5‧ mature miRNAs candidates from their pre-miRNA based on ensemble SVM classifiers with idea of adaboost. Firstly, the balanced-dataset was extract based on K-nearest neighbor algorithm. Secondly, the multiple SVM classifiers were trained in orderly using the balance datasets base on represented features. At last, all SVM classifiers were combined together to form the ensemble classifier. Our results on independent testing dataset show that the proposed method is more efficient than one without treating class imbalance problem. Moreover, MatFind achieves much higher classification accuracy than other three approaches. The ensemble SVM classifiers and balanced-datasets can solve the class-imbalanced problem, as well as improve performance of classifier for mature miRNA identification. MatFind is an accurate and fast method for 5‧ mature miRNA identification.

  6. Distribution of microRNA co-targets exhibit universality across a wide class of species

    Science.gov (United States)

    Basu, Mahashweta; Bhattacharyya, Nitai P.; Mohanty, P. K.

    2014-01-01

    MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression by binding to the 3' UTR of the corresponding messenger RNAs. We construct miRNA co-target networks for a wide class of species (22 in total) using a target prediction database, MicroCosm Targets. For each species, miRNA pairs having one or more common target genes are connected and the number of co-targets are assigned as the weight of these links. We show that the link-weight distributions of all the species collapse remarkably onto each other when scaled suitably —the scale-factor turns out to be a measure of complexity of the species. A simple model, where targets are chosen randomly by miRNAs, could provide the correct scaling function and suggest that the increase of species complexity is related to the increase of the fraction of genes typically targeted by their miRNAs.

  7. Circulating microRNAs as a Novel Class of Potential Diagnostic Biomarkers in Neuropsychiatric Disorders

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    Kichukova Tatyana M.

    2015-12-01

    Full Text Available Neuropsychiatric diseases, such as schizophrenia, bipolar disorder (BD, major depressive disorder (MDD and autism spectrum disorder (ASD, are a huge burden on society, impairing the health of those affected, as well as their ability to learn and work. Biomarkers that reflect the dysregulations linked to neuropsychiatric diseases may potentially assist the diagnosis of these disorders. Most of these biomarkers are found in the brain tissue, which is not easily accessible. This is the challenge for the search of novel biomarkers that are present in various body fluids, including serum or plasma. As a group of important endogenous small noncoding RNAs that regulate gene expression at post-transcriptional level, microRNAs (miRNAs play a crucial role in many physiological and pathological processes. Previously, researchers discovered that miRNAs contribute to the neurodevelopment and maturation, including neurite outgrowth, dendritogenesis and dendritic spine formation. These developments underline the significance of miRNAs as potential biomarkers for diagnosing and prognosing central nervous system diseases. Accumulated evidence indicates that there are considerable differences between the cell-free miRNA expression profiles of healthy subjects and those of patients. Therefore, circulating miRNAs are likely to become a new class of noninvasive, sensitive biomarkers. Despite the fact that little is known about the origin and functions of circulating miRNAs, their essential roles in the clinical diagnosis and prognosis of neuropsychiatric diseases make them attractive biomarkers. In this review we cover the increasing amounts of dataset that have accumulated in the last years on the use of circulating miRNAs and their values as potential biomarkers in most areas of neuropsychiatric diseases.

  8. Feature Selection Has a Large Impact on One-Class Classification Accuracy for MicroRNAs in Plants

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    Malik Yousef

    2016-01-01

    Full Text Available MicroRNAs (miRNAs are short RNA sequences involved in posttranscriptional gene regulation. Their experimental analysis is complicated and, therefore, needs to be supplemented with computational miRNA detection. Currently computational miRNA detection is mainly performed using machine learning and in particular two-class classification. For machine learning, the miRNAs need to be parametrized and more than 700 features have been described. Positive training examples for machine learning are readily available, but negative data is hard to come by. Therefore, it seems prerogative to use one-class classification instead of two-class classification. Previously, we were able to almost reach two-class classification accuracy using one-class classifiers. In this work, we employ feature selection procedures in conjunction with one-class classification and show that there is up to 36% difference in accuracy among these feature selection methods. The best feature set allowed the training of a one-class classifier which achieved an average accuracy of ~95.6% thereby outperforming previous two-class-based plant miRNA detection approaches by about 0.5%. We believe that this can be improved upon in the future by rigorous filtering of the positive training examples and by improving current feature clustering algorithms to better target pre-miRNA feature selection.

  9. Nova República: a violência patronal rural como prática de classe New Republic: landowners' violence as a class practice

    Directory of Open Access Journals (Sweden)

    Regina Angela Landim Bruno

    2003-01-01

    Full Text Available Durante a Nova República, disseminou-se junto às associações e sindicatos patronais rurais a certeza de "uma verdadeira guerra no campo" e a "inevitabilidade" da violência como única medida eficaz para conter as ações de ocupação de terras e a demanda por uma reforma agrária. O objetivo deste trabalho é mostrar, tendo como fonte o debate na grande imprensa, que a defesa e a prática da violência pelos grandes proprietários de terra e empresários rurais é estruturante e reflete um habitus que encadeia o passado e o presente numa mesma realidade. A violência revela-nos o conteúdo das relações de classe e expõe os componentes de velhos e novos padrões de conduta. Nos anos 80, ela funcionou como reforço à solidariedade e ao sentimento de pertencimento e serviu também para fortalecer ainda mais a convicção da superioridade dos proprietários sobre os trabalhadores rurais. Não se trata de um ato individual e esporádico; é uma violência ritualizada e institucionalizada, que implica a formação de milícias, a contratação de capangas, a lista dos marcados para morrer e os massacres. E nesse contexto, pouco se distingue o novo empresário do latifundiário tradicional, ou a voz "civilizada das urbes" da "rudeza dos grotões".During the 1980's so-called New Republic in Brazil, a conviction was disseminated throughout rural employers' organizations of "a real rural war" and of the "unavoidability" of violence as the only effective action to stop land occupation and the demand for agrarian reform. The aim of this work is to demonstrate - based on the debate on the mainstream press - that defense and practice of violence by big landowners and rural businessmen is structuring and reflects an habitus that links past and present in one reality. Violence discloses the content of class relations and displays the contents of old and new standards of conduct. In the 1980s, it worked to reinforce solidarity and the sense of

  10. Prosperidade sim, família homossexual, não! A nova classe média evangélica

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    Jung Mo Sung

    2015-04-01

    Full Text Available Dentre a chamada "nova classe média", um grupo social se destaca por sua atuação social e política em defesa do modelo tradicional de família e contra o casamento de pessoas do mesmo sexo e as relações homoafetivas: os evangélicos da linha da teologia da prosperidade. Este artigo pretende mostrar que o conservadorismo moral militante e a adesão aos valores modernos e pós-modernos da cultura de consumo capitalista, por meio da teologia da prosperidade, não são aspectos contraditórios ou um descompasso no processo de modernização desse grupo, mas que são dois lados de um único processo de afirmação de sua dignidade humana.

  11. Novae news

    CERN Multimedia

    2012-01-01

    As announced in the previous Bulletin, Novae has opened a new snack bar on the Flagstaff car park, just a few metres from CERN's reception area (Building 33).   Just a few metres from the CERN Reception, the new Novae snack point welcomes visitors and CERNois. Opening hours Currently: Monday to Friday, 8 a.m. to 4 p.m. From September: Monday to Friday, 7:45 a.m. to 5 p.m.; Saturdays from 8 a.m. to 2 p.m. The snack bar selection includes breakfast, starting at 2.70 CHF, cold dishes from 5 CHF, and hot dishes from 6 CHF.   Novae has also installed a 24-hour-a-day food vending machine in the CERN hostel (Building 39) and in Building 13. You can buy pasta and cooked dishes for 6.50 CHF to 8 CHF. In addition, a groceries vending machine has been installed in the main building, just across from the news kiosk. Nearly 60 different items are available around the clock. Finally, Novae has introduced a new payment system in several buildings on the Meyrin site. It accepts credit ca...

  12. Rumo a uma nova conceituação histórica da classe trabalhadora mundial Towards a new historical conceptualization of the world working class

    Directory of Open Access Journals (Sweden)

    Marcel van der Linden

    2005-01-01

    Full Text Available Este artigo apresenta uma discussão historiográfica sobre o conceito de classe trabalhadora levando em conta as diversas experiências históricas desde o século XIX. A questão a ser enfocada nas páginas seguintes é como podemos visualizar um novo conceito da classe trabalhadora levando em conta as contribuições oferecidas por Breman, Gooptu, Linebaugh e outros. A fim de encontrar uma resposta a essa questão, o artigo realiza uma crítica construtiva do conceito de classe trabalhadora em Marx.This article presents an historiographical discussion about the working class concept, dealing with the historical experiences since XIX century . The question addressed in the following pages is what a new concept of the working class might look like that would take into account the insights offered by Breman, Gooptu, Linebaugh and others. In order to find an answer to this question, it starts off with a constructive critique of Marx' concept of the working class.

  13. Multiple independent analyses reveal only transcription factors as an enriched functional class associated with microRNAs

    Directory of Open Access Journals (Sweden)

    Croft Larry

    2012-07-01

    Full Text Available Abstract Background Transcription factors (TFs have long been known to be principally activators of transcription in eukaryotes and prokaryotes. The growing awareness of the ubiquity of microRNAs (miRNAs as suppressive regulators in eukaryotes, suggests the possibility of a mutual, preferential, self-regulatory connectivity between miRNAs and TFs. Here we investigate the connectivity from TFs and miRNAs to other genes and each other using text mining, TF promoter binding site and 6 different miRNA binding site prediction methods. Results In the first approach text mining of PubMed abstracts reveal statistically significant associations between miRNAs and both TFs and signal transduction gene classes. Secondly, prediction of miRNA targets in human and mouse 3’UTRs show enrichment only for TFs but not consistently across prediction methods for signal transduction or other gene classes. Furthermore, a random sample of 986 TarBase entries was scored for experimental evidence by manual inspection of the original papers, and enrichment for TFs was observed to increase with score. Low-scoring TarBase entries, where experimental evidence is anticorrelated miRNA:mRNA expression with predicted miRNA targets, appear not to select for real miRNA targets to any degree. Our manually validated text-mining results also suggests that miRNAs may be activated by more TFs than other classes of genes, as 7% of miRNA:TF co-occurrences in the literature were TFs activating miRNAs. This was confirmed when thirdly, we found enrichment for predicted, conserved TF binding sites in miRNA and TF genes compared to other gene classes. Conclusions We see enrichment of connections between miRNAs and TFs using several independent methods, suggestive of a network of mutual activating and suppressive regulation. We have also built regulatory networks (containing 2- and 3-loop motifs for mouse and human using predicted miRNA and TF binding sites and we have developed a web server

  14. A chamada "nova classe média": cultura material, inclusão e distinção social

    Directory of Open Access Journals (Sweden)

    Hilaine Yaccoub

    2011-12-01

    Full Text Available O presente artigo tem como objetivo apresentar uma discussão sobre a importância do consumo e cultura material para um determinado estrato social. A partir de uma pesquisa realizada sobre ligações clandestinas de energia elétrica, fenômeno sociotécnico de dimensões culturais conhecido por "gatos", residi por oito meses em um bairro popular na região metropolitana do Rio de Janeiro. Como moradora, pude penetrar na vida do bairro e analisar o estilo de vida de um grupo de moradores considerado a elite local, que, àquela época, fazia parte de um contingente mais amplo da população brasileira que estava adquirindo visibilidade pública, sendo denominado pela mídia como "nova classe média". Devido ao aumento da renda, à política de juros baixos e aos financiamentos facilitados a partir do Plano Real, esses "novos consumidores" obtiveram mais acesso a bens duráveis, especialmente eletroeletrônicos, elevando assim seu status perante seus iguais e muitas vezes adequando através de táticas seu novo padrão de consumo. Por meio do consumo, principalmente de carros e eletroeletrônicos, eles almejam inclusão em outro estrato social, as camadas médias urbanas.The aim of this article is discussing the importance of consuming and material culture for a determined social strata. In order to carry out research on illegal energy hook-ups, a social and technical phenomenon with a strong cultural dimension, I lived for eight months in a lower-class neighborhood in Greater Metropolitan Rio de Janeiro. As a resident of the neighborhood, I had insider access to the way of life there and was thus able to study the lifestyle of the so-called local elite, who were part of the segment of the Brazilian population increasingly acknowledged by the media as the "new middle class". As a result of increased income, low interest rates and greater access to financing created by the Plano Real, these "new consumers" were now able to purchase durable goods

  15. Magnetic novae

    Science.gov (United States)

    Zemko, Polina; Orio, Marina

    2016-07-01

    We present the results of optical and X-ray observations of two quiescent novae, V2491 Cyg and V4743 Sgr. Our observations suggest the intriguing possibility of localization of hydrogen burning in magnetic novae, in which accretion is streamed to the polar caps. V2491 Cyg was observed with Suzaku more than 2 years after the outburst and V4743 Sgr was observed with XMM Newton 2 and 3.5 years after maximum. In the framework of a monitoring program of novae previously observed as super soft X-ray sources we also obtained optical spectra of V4743 Sgr with the SALT telescope 11.5 years after the eruption and of V2491 Cyg with the 6m Big Azimutal Telescope 4 and 7 years post-outburst. In order to confirm the possible white dwarf spin period of V2491 Cyg measured in the Suzaku observations we obtained photometric data using the 90cm WIYN telescope at Kitt Peak and the 1.2 m telescope in Crimea. We found that V4743 Sgr is an intermediate polar (IP) and V2491 Cyg is a strong IP candidate. Both novae show modulation of their X-ray light curves and have X-ray spectra typical of IPs. The Suzaku and XMM Newton exposures revealed that the spectra of both novae have a very soft blackbody-like component with a temperature close to that of the hydrogen burning white dwarfs in their SSS phases, but with flux by at least two orders of magnitude lower, implying a possible shrinking of emitting regions in the thin atmosphere that is heated by nuclear burning underneath it. In quiescent IPs, independently of the burning, an ultrasoft X-ray flux component originates at times in the polar regions irradiated by the accretion column, but the soft component of V4743 Sgr disappeared in 2006, indicating that the origin may be different from accretion. We suggest it may have been due to an atmospheric temperature gradient on the white dwarf surface, or to continuing localized thermonuclear burning at the bottom of the envelope, before complete turn-off. The optical spectra of V2491 Cyg and V

  16. Nova Delphini 2013: Backyard Analysis of a Classical Nova

    Science.gov (United States)

    Reid, Piper

    2014-01-01

    On August 14, 2013, Nova Delphini was discovered by Koichi Itagaki. This nova erupted to a maximum brightness of magnitude 4.4 by August 16, 2013. The extraordinary brightness of this event has allowed many amateur astronomers to have the chance to study it. More than 750 amateur astronomers have contributed to the AAVSO photometry database of Nova Delphini.1 The amount and quality of spectroscopic data gathered is unprecedented as well, as over 700 individual spectra have been collected so far in the ARAS database.2 A nova is a class of variable star that undergoes a cataclysmic eruption, which can be observed through a sudden increase in brightness that declines over a series of months or years. At the center of a nova is an accreting white dwarf star which is collecting hydrogen from its surroundings. The accreting mass causes a nuclear reaction on the surface of the white dwarf and as the pressure increases the reaction becomes super-critical and a thermonuclear runaway is ignited causing the brightness increase as well as triggering the ejection of a shell of material form the star. The stages of a classical nova outburst are outlined along with techniques available to amateur astronomers for study of these phenomena. The author’s equipment and software setup are detailed. Results obtained using a low resolution grating, Schmidt-cassegrain telescope and CCD camera that were acquired while Nova Delphini was in the “fireball stage” 3 and subsequent “iron curtain phase”3 are compared and discussed. Results obtained using a high resolution spectroscope, Schmidt-cassegrain telescope and CCD camera that were acquired during the “lifting of the iron curtain phase”3 are also presented. References 1. Turner, Rebecca. “AAVSO - Nova Del 2013” 20 Aug 2013 Web. 8 Sep 2013 2. Tessier, Francois. “ARAS Spectral Database - Nova-Del-2013” 22 Sep 2013 Web. 22 Sep 2013 3. Shore, Steven N. “Spectroscopy of Novae - A User’s Manual” arXiv:1211.3176 [astro

  17. Multiple independent analyses reveal only transcription factors as an enriched functional class associated with microRNAs

    DEFF Research Database (Denmark)

    Croft, Laurence J; Szklarczyk, Damian; Jensen, Lars J

    2012-01-01

    ABSTRACT: BACKGROUND: Transcription factors (TFs) have long been known to be principally activators of transcription in eukaryotes and prokaryotes. The growing awareness of the ubiquity of microRNAs (miRNAs) as suppressive regulators in eukaryotes, suggests the possibility of a mutual, preferential...

  18. A Spectroscopic and Photometric Survey of Novae in M31

    CERN Document Server

    Shafter, A W; Hornoch, K; Filippenko, A V; Bode, M F; Ciardullo, R; Misselt, K A; Hounsell, R A; Chornock, R; Matheson, T

    2011-01-01

    We report the results of a multi-year spectroscopic and photometric survey of novae in M31 that resulted in a total of 53 spectra of 48 individual nova candidates. Two of these, M31N 1995-11e and M31N 2007-11g, were revealed to be long-period Mira variables, not novae. These data double the number of spectra extant for novae in M31 through the end of 2009 and bring to 91 the number of M31 novae with known spectroscopic classifications. We find that 75 novae (82%) are confirmed or likely members of the Fe II spectroscopic class, with the remaining 16 novae (18%) belonging to the He/N (and related) classes. These numbers are consistent with those found for Galactic novae. We find no compelling evidence that spectroscopic class depends sensitively on spatial position or population within M31 (i.e., bulge vs. disk), although the distribution for He/N systems appears slightly more extended than that for the Fe II class. We confirm the existence of a correlation between speed class and ejection velocity (based on l...

  19. The Wendelstein Calar Alto Pixellensing Project (WeCAPP): the M 31 nova catalogue

    Science.gov (United States)

    Lee, C.-H.; Riffeser, A.; Seitz, S.; Bender, R.; Fliri, J.; Hopp, U.; Ries, C.; Bärnbantner, O.; Gössl, C.

    2012-01-01

    We present light curves from the novae detected in the long-term, M 31-monitoring WeCAPP project. The goal of WeCAPP is to constrain the compact dark matter fraction of the M 31 halo with microlensing observations. As a by product we detected 91 novae benefiting from the high cadence and highly sensitive difference imaging technique required for pixel-lensing. We thus can now present the largest sample of optical/CCD nova lightcurves towards M 31 to date. We also obtained thorough coverage of the light curve before and after the eruption thanks to the long-term monitoring. We apply a nova taxonomy to our nova candidates and found 29 S-class novae, 10 C-class novae, 2 O-class novae, and 1 J-class nova. We investigated a universal decline law on the S-class novae. In addition, we correlated our catalogue with the literature and found 4 potential recurrent novae. Part of our catalogue has been used to search for optical counterparts of the super soft X-ray sources detected in M 31. Optical surveys like WeCAPP, when coordinated with multi-wavelength observation, will continue to shed light on the underlying physical mechanism of novae in the future.

  20. Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases

    Institute of Scientific and Technical Information of China (English)

    Xi Chen; Xing Guo; Qibin Li; Xiaoying Li; Wenjing Wang; Yan Zhang; Jin Wang; Xueyuan Jiang; Yang Xiang; Chen Xu; Pingping Zheng; Yi Ba; Juanbin Zhang; Ruiqiang Li; Hongjie Zhang; Xiaobin Shang; Ting Gong; Guang Ning; Jun Wang; Ke Zen; Junfeng Zhang; Chen-Yu Zhang; Lijia Ma; Xing Cai; Yuan Yin; Kehui Wang; Jigang Guo; Yujing Zhang; Jiangning Chen

    2008-01-01

    Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases,including cancers.Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice,rats,bovine fetuses,calves,and horses.The levels of miRNAs in serum are stable,reproduc ible,and consistent among individuals of the same species.Employing Solexa,we sequenced all serum miRNAs of healthy Chinese subjects and found over 100 and 91 serum miRNAs in male and female subjects,respectively.We also identified specific expression patterns of serum miRNAs for lung cancer,colorectal cancer,and diabetes,provid ing evidence that serum miRNAs contain fingerprints for various diseases.Two non-small cell lung cancer-specific se-rum miRNAs obtained by Solexa were further validated in an independent trial of 75 healthy donors and 152 cancer patients,using quantitative reverse transcription polymerase chain reaction assays.Through these analyses,we conclude that serum miRNAs can serve as potential biomarkers for the detection of various cancers and other diseases.

  1. Recovery of old novae

    Directory of Open Access Journals (Sweden)

    L. Schmidtobreick

    2004-01-01

    Full Text Available Durante un proyecto a largo plazo dedicado a la investigaci on de novas cl asicas con explosiones de grandes amplitudes hemos llevado a cabo fotometr a a m ultiples longitudes de onda y espectroscop a optica de varios candidatos de novas viejas. Introducimos aqu el objetivo del proyecto, la b usqueda de novas con baja trans- ferencia de masa y per odos orbitales cortos, y explicamos el m etodo para recuperar estas novas viejas a trav es de sus caracter sticas de color. Finalmente nos concentramos en los primeros resultados para una selecci on de objetos de nuestra muestra.

  2. Micro-RNAs

    DEFF Research Database (Denmark)

    Taipaleenmäki, H.; Hokland, L. B.; Chen, Li

    2012-01-01

    Osteoblast differentiation and bone formation (osteogenesis) are regulated by transcriptional and post-transcriptional mechanisms. Recently, a novel class of regulatory factors termed microRNAs has been identified as playing an important role in the regulation of many aspects of osteoblast biology...... including proliferation, differentiation, metabolism and apoptosis. Also, preliminary data from animal disease models suggest that targeting miRNAs in bone can be a novel approach to increase bone mass. This review highlights the current knowledge of microRNA biology and their role in bone formation...

  3. Insights into the potential use of microRNAs as a novel class of biomarkers in esophageal cancer.

    Science.gov (United States)

    Wan, J; Wu, W; Che, Y; Kang, N; Zhang, R

    2016-07-01

    MicroRNAs (abbreviated miRNAs) have been demonstrated to be involved in tumorigenesis and cancer development and proposed as promising biomarkers in cancer diagnosis. Numerous studies have observed the aberrant expression of miRNAs in esophageal cancer. However, there are some discrepant results. Thus, we conducted this meta-analysis to identify the overall accuracy of miRNAs in the diagnosis of esophageal cancer. A comprehensive literature search was conducted in PubMed and other databases using combinations of key words. The summary receiver operator characteristic curves were plotted to assess the overall diagnostic performance of miRNAs. Chi-squared and I(2) tests were used to assess the heterogeneity between studies. Additionally, we conducted subgroup and sensitivity analyses to analyze the potential sources of heterogeneity. In total, 33 studies from 12 articles were available in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR) diagnostic odds ratio, and area under the curve were 0.80, 0.80, 4.0, 0.25, 16, and 0.87, respectively. Subgroup analyses based on the sample types (saliva-, serum- and plasma-based) showed no differences in the diagnostic accuracy of each subgroup. An independent meta-analysis of eight articles was conducted to evaluate the diagnostic accuracy of miRNAs in patients with esophageal squamous cell carcinoma, with a pooled sensitivity of 0.77, specificity of 0.83, PLR of 4.4, NLR of 0.27, diagnostic odds ratio of 16, and area under the curve of 0.87. In conclusion, this meta-analysis demonstrates the feasibility of using miRNAs as non-invasive biomarkers to discriminate esophageal cancer from healthy controls. However, further high-quality studies on more clearly defined esophageal cancer patient are needed to confirm our conclusion. © 2015 International Society for Diseases of the Esophagus.

  4. The Wendelstein Calar Alto Pixellensing Project (WeCAPP): the M31 Nova catalogue

    CERN Document Server

    Lee, C -H; Seitz, S; Bender, R; Fliri, J; Hopp, U; Ries, C; Baernbantner, O; Goessl, C

    2011-01-01

    We present light curves from the novae detected in the long-term, M31 monitoring WeCAPP project. The goal of WeCAPP is to constrain the compact dark matter fraction of the M31 halo with microlensing observations. As a by product we have detected 91 novae benefiting from the high cadence and highly sensitive difference imaging technique required for pixellensing. We thus can now present the largest CCD and optical filters based nova light curve sample up-to-date towards M31. We also obtained thorough coverage of the light curve before and after the eruption thanks to the long-term monitoring. We apply the nova taxonomy proposed by Strope et al. (2010) to our nova candidates and found 29 S-class novae, 10 C-class novae, 2 O-class novae and 1 J-class nova. We have investigated the universal decline law advocated by Hachichu and Kato (2006) on the S-class novae. In addition, we correlated our catalogue with the literature and found 4 potential recurrent novae. Part of our catalogue has been used to search for opt...

  5. Radioactive Nova Zembla; Nova Zembla radioactief

    Energy Technology Data Exchange (ETDEWEB)

    Duursma, E.

    1996-10-01

    The former Soviet Union dumped radioactive wastes in the seas around the island Nova Zembla (Novaya Zemlya) for decades. Complete nuclear reactors were sunk down. In this non-specialist article the risks from this Cold War heritage are discussed. 4 figs., 1 tab., 1 ref.

  6. Recurrent Novae - A Review

    CERN Document Server

    Mukai, Koji

    2014-01-01

    In recent years, recurrent nova eruptions are often observed very intensely in wide range of wavelengths from radio to optical to X-rays. Here I present selected highlights from recent multi-wavelength observations. The enigma of T Pyx is at the heart of this paper. While our current understanding of CV and symbiotic star evolution can explain why certain subset of recurrent novae have high accretion rate, that of T Pyx must be greatly elevated compared to the evolutionary mean. At the same time, we have extensive data to be able to estimate how the nova envelope was ejected in T Pyx, and it turns to be a rather complex tale. One suspects that envelope ejection in recurrent and classical novae in general is more complicated than the textbook descriptions. At the end of the review, I will speculate that these two may be connected.

  7. Nova Aquila 1919: a nova after all?

    CERN Document Server

    Lau, Herbert H B; Liu, X W

    2010-01-01

    Nova 1919 Aquila is today widely assumed to have been the result of a final helium shell flash occurring on a single post-asymptotic giant branch star. The fact that the outbursting star is in the middle of an old planetary nebula and that the ejecta associated with the outburst is hydrogen deficient supports this diagnosis. However, the material ejected during that outburst is also extremely neon rich, suggesting that it derives from an oxygen-neon-magnesium star, as is the case in the so-called neon novae. We have therefore attempted to construct a scenario that explains all the observations of the nebula and its central star, including the ejecta abundances. We find two scenarios that have the potential to explain the observations, although neither is a perfect match. The first scenario invokes the merger of a main sequence star and a massive oxygen-neon-magnesium white dwarf. The second invokes an oxygen-neon-magnesium classical nova that takes place shortly after a final helium shell flash. The main draw...

  8. The UBV Color Evolution of Classical Novae. II. Color-Magnitude Diagram

    CERN Document Server

    Hachisu, Izumi

    2016-01-01

    We have examined the outburst tracks of 40 novae in the color-magnitude diagram (intrinsic B-V color versus absolute V magnitude). After reaching the optical maximum, each nova generally evolves toward blue from the upper-right to the lower-left and then turns back toward the right. The 40 tracks are categorized into one of six templates: very fast nova V1500 Cyg; fast novae V1668 Cyg, V1974 Cyg, and LV Vul; moderately fast nova FH Ser; and very slow nova PU Vul. These templates are located from the left (blue) to the right (red) in this order, depending on the envelope mass and nova speed class. A bluer nova has a less massive envelope and faster nova speed class. In novae with multiple peaks, the track of the first decay is more red than that of the second (or third) decay, because a large part of the envelope mass had already been ejected during the first peak. Thus, our newly obtained tracks in the color-magnitude diagram provide useful information to understand the physics of classical novae. We also fou...

  9. MicroRNAs as regulatory elements in psoriasis

    Directory of Open Access Journals (Sweden)

    Liu Yuan

    2016-01-01

    Full Text Available Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis. microRNA participates in nearly all biological processes, such as cell differentiation, development and metabolism. Recent researches reveal that multitudinous novel microRNAs have been identified in skin. Some of these substantial novel microRNAs play as a class of posttranscriptional gene regulator in skin disease, such as psoriasis. In order to insight into microRNAs biological functions and verify microRNAs biomarker, we review diverse references about characterization, profiling and subtype of microRNAs. Here we will share our opinions about how and which microRNAs are as regulatory in psoriasis.

  10. New Novae snack point

    CERN Multimedia

    2012-01-01

    Located next to the car park by the flag poles, a few metres from the Main CERN Reception (building 33), a new snack point catered by Novae will open to the public on Wednesday 8 August. More information will be available in the next issue of the Bulletin!

  11. Aprendizagens e novas tecnologias

    Directory of Open Access Journals (Sweden)

    Pedro Demo*

    2011-06-01

    Full Text Available Pretendo aqui, muito preliminarmente, reunir alguns argumentos favoráveis à multiplicidade de oportunidades de aprender que o aluno pode encontrar hoje em ambientes de aprendizagem mediados por novas tecnologias. Centro-me principalmente na desconstrução de algumas resistências pedagógicas (EVANS, 2001 ainda persistentes entre nós como “transmissão de conteúdos”; agarramento a uma única teoria; fixação na aula instrucionista; extirpação/endeusamento de processos avaliativos, etc. Procuro ver, em um vasto âmbito de ofertas teóricas, componentes atualmente ressaltados na discussão tecnológica em vigor, com o objetivo de indicar oportunidades de reconstrução muito aproveitável de autores e clássicos, uma vez que aprender bem não foi algo inventado pelas novas tecnologias; sempre existiu e os grandes pedagogos tiveram consciência disso, insinuando infinitas maneiras de aprender bem (DEMO, 2008. As novas tecnologias proporcionam oportunidades ainda mais ampliadas, em meio também a enormes riscos e desacertos. O que menos interessa aqui é incidir em panaceias tecnológicas, bem a gosto do consumismo neoliberal. Interessa, porém, explorar novas oportunidades de aprendizagem, bem mais centradas na atividade dos alunos, flexíveis, motivadoras e capazes de sustentar processos de autoria e autonomia.

  12. The Galactic Nova Rate Revisited

    CERN Document Server

    Shafter, A W

    2016-01-01

    Despite its fundamental importance, a reliable estimate of the Galactic nova rate has remained elusive. Here, the overall Galactic nova rate is estimated by extrapolating the observed rate for novae reaching $m\\leq2$ to include the entire Galaxy using a two component disk plus bulge model for the distribution of stars in the Milky Way. The present analysis improves on previous work by considering important corrections for incompleteness in the observed rate of bright novae. Several models are considered to account for differences in the assumed properties of bulge and disk nova populations. The simplest models, which assume uniform properties between bulge and disk novae, predict Galactic nova rates between $\\sim$50 to as many as $\\sim$100 per year, depending on the assumed incompleteness at bright magnitudes. Models where the disk novae are assumed to be more luminous than bulge novae are explored, and predict nova rates up to 30% lower, in the range of $\\sim$35 to $\\sim$70 per year. An average of the most p...

  13. Vila Nova de Gaia

    OpenAIRE

    Almeida, Salvador de Pinho Ferreira de

    2012-01-01

    Tese de doutoramento em Geografia, no ramo de Geografia Física, apresentado à Faculdade de Letras da Universidade de Coimbra The Old Historic Centre of Vila Nova de Gaia is a real living document of the life conditions and construction techniques of ancestral generations representative of cultural values, namely historical, architectural, urbanistic or just emotional that cannot be lost by neglect or carelessness, as they constitute a collective memory. It is necessary to draw ...

  14. NOVAS TECNOLOGIAS NO ENVELHECIMENTO

    Directory of Open Access Journals (Sweden)

    Rosa Maria Farah

    2010-02-01

    Full Text Available O Programa de Estudos Pós-Graduados em Gerontologia/PUC-SP desenvolve pesquisas em diversificadas linhas algumas das quais têm em comum o acolhimento à questão das novas tecnologias no envelhecimento. São investigações de caráter interdisciplinar que envolvem docentes-pesquisadores, orientandos de mestrado e de iniciação científica. Na área da educação a distância, a PUC-SP inaugura um trabalho em que o idoso interessado em avançar em seus conhecimentos é recebido em um ambiente virtual de aprendizagem, em que pode participar de cursos avançados de aquisição de novas linguagens e de navegação na Internet, cujas consequências são o investimento em uma via mais digna para o envelhecer no sentido de esse idoso sentir-se um ser ligado aos novos tempos em que a interatividade digital traz-lhe possibilidades ilimitadas de contatos com o outro, com o mundo enfim. A pesquisa sobre a inclusão cibersocial do idoso mostra o que significa colocar o idoso em contato com a Internet, quando este recebe, por meio das redes sociais, ofertas de várias ordens, e equipamentos que contornam limitações de ordem física ou motora. Além disso, o registro digital da memória do idoso, de sua história e referências também podem constituir conteudos preciosos para pesquisas. A relação do idoso com a informática pode situá-lo como um ator, produtor e reprodutor no ciberespaço. Isso significa que as vantagens do uso do computador fazem o idoso ganhar novo sentido na vida, na medida em que pode assim preencher o vazio causado pelas perdas que lhe vão ocorrendo, possibilitando que ele redimensione seu olhar para o presente e futuro. Palavras-chave: o sujeito-idoso nas novas tecnologias; novas tecnologias e envelhecimento; o idoso na educação a distância; internet na velhice.

  15. Recurrent Novae in M31

    CERN Document Server

    Shafter, A W; Rector, T A; Schweizer, F; Hornoch, K; Orio, M; Pietsch, W; Darnley, M J; Williams, S C; Bode, M F; Bryan, J

    2014-01-01

    The reported positions of 964 suspected nova eruptions in M31 recorded through the end of calendar year 2013 have been compared in order to identify recurrent nova candidates. To pass the initial screen and qualify as a recurrent nova candidate two or more eruptions were required to be coincident within 0.1', although this criterion was relaxed to 0.15' for novae discovered on early photographic patrols. A total of 118 eruptions from 51 potential recurrent nova systems satisfied the screening criterion. To determine what fraction of these novae are indeed recurrent the original plates and published images of the relevant eruptions have been carefully compared. This procedure has resulted in the elimination of 27 of the 51 progenitor candidates (61 eruptions) from further consideration as recurrent novae, with another 8 systems (17 eruptions) deemed unlikely to be recurrent. Of the remaining 16 systems, 12 candidates (32 eruptions) were judged to be recurrent novae, with an additional 4 systems (8 eruptions) b...

  16. Franchising in Nova Scotia

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, G. [Nova Scotia Petroleum Directorate, Halifax, NS (Canada)

    1998-09-01

    Opportunities for the local distribution of natural gas in Nova Scotia were reviewed, with special emphasis on franchising. Franchising in Nova Scotia began in 1980, made possible by the passage of the Gas Utilities Act and the Pipeline Act which promised western Canadian natural gas to eastern Canada. However, proposals for franchisees to distribute natural gas in the province were abandoned as the hope for natural gas transmission service to the province faded. The plummeting of world oil prices by the mid-1980s was also a contributory factor. Discovery and development of natural gas facilities around Sable Island led to the September 1997 proclamation of the Gas Distribution Act, which also led to the revival of interest in franchising. The Act provides for the competitive marketing of natural gas as a commodity and the regulation of the gas delivery system under a franchise agreement. Competitive applications are expected early in 1998, with awards of franchises in late 1998. Construction and gas delivery services should begin operations late in 1999.

  17. Terra Nova update

    Energy Technology Data Exchange (ETDEWEB)

    Carrick, G. [Petro-Canada, Inc. (Canada)

    2002-07-01

    This power point presentation shows a location map of the offshore oil and gas fields found off the Grand Banks of Newfoundland. It depicts the proximity of the Terra Nova oil field to Hibernia, White Rose, and the Hebron/Ben Nevis oil fields. The progress of the Terra Nova project since 2001 is described along with the commissioning challenges regarding turret and moorings as well as its modules, underwater components, flow lines, offshore marine operation, well construction and offshore start up. The 2002 operations schedule is also presented, along with production performance, and drilling/completions performance. A chart depicting environment, health and safety (EHS) indicators show that the current focus is on achieving superior environmental performance, injury free and to achieve the EHS performance target in the leading/lagging indicator ratio. Other current issues include the achievement of stable gas compression and sustained production, and to test the full capacity of the FPSO up to 150,000 barrels per day. The drivers of the first quartile performance include unit lifting costs, operating costs, and production efficiency. Operating costs include maintenance, platform support, logistics, onshore support, and well work. The project signifies tremendous growth opportunities for the east coast offshore petroleum industry. tabs., figs.

  18. Nova Mus 2008 = QY Mus

    Science.gov (United States)

    Templeton, Matthew R.

    2008-10-01

    Nova Mus 2008 = QY Mus was discovered by William Liller, Vina del Mar, Chile, on 2008 September 28.998 UT at magnitude 8.6 (Tech Pan film + orange filter). The position is RA = 13h 16m 36.44s , Dec = -67d 36m 47.8s (from P. Nelson). This object was announced as a nova in IAU Circular 8990 (Daniel W.E. Green, editor). The nova classification was determined using low-resolution spectra by W. Liller indicating the presence of broad H-alpha lines at least 2300 angstroms wide. Several observers confirmed the nova and provided photometry. The position above was provided by Peter Nelson (Ellinbank, Vic., Aus.), and is averaged from four separate exposures (rms error approx. 0.4 arcseconds). The GCVS team have formally designated Nova Mus 2008 as QY MUS. Observations should be reported to the AAVSO International Database as QY MUS.

  19. Nova KT Eri 2009: Infrared studies of a very fast and small amplitude He/N nova

    CERN Document Server

    Raj, Ashish; Ashok, N M

    2013-01-01

    We present near-infrared spectroscopic and photometric observations of the nova KT Eridani taken during the first 100 days following its discovery in 2009 November. The JHK spectra of the object have been taken from the Mount Abu Infrared Observatory using the Near-Infrared Imager/Spectrometer. The spectra, typical of the He/N class novae, show strong He I emission lines together with H I and O I emission features. The H I, Pa-beta and Br-gamma spectral lines and the He I line at 2.0581 micron show broad wings with a relatively narrow central component. The broad wings extend to 1900 km/s while the central component has FWHM of 2100 km/s. The V and near-infrared JHK light curves show an additional small amplitude outburst near 40 days after optical maximum. The distance to the nova d = 6.3 +/- 0.1 kpc is derived using the MMRD relation and the estimated value of t2 = 5.7 +/- 0.3 days. The small value of t2 places KT Eri in the class of very fast novae. Using the value of the distance to the nova d, we estimat...

  20. RECURRENT NOVAE IN M31

    Energy Technology Data Exchange (ETDEWEB)

    Shafter, A. W. [Department of Astronomy, San Diego State University, San Diego, CA 92182 (United States); Henze, M. [European Space Astronomy Centre, P.O. Box 78, E-28692 Villanueva de la Cañada, Madrid (Spain); Rector, T. A. [Department of Physics and Astronomy, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508 (United States); Schweizer, F. [Carnegie Observatories, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Hornoch, K. [Astronomical Institute, Academy of Sciences, CZ-251 65 Ondřejov (Czech Republic); Orio, M. [Astronomical Observatory of Padova (INAF), I-35122 Padova (Italy); Pietsch, W. [Max Planck Institute for Extraterrestrial Physics, P.O. Box 1312, Giessenbachstr., D-85741, Garching (Germany); Darnley, M. J.; Williams, S. C.; Bode, M. F. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool L3 5RF (United Kingdom); Bryan, J., E-mail: aws@nova.sdsu.edu [McDonald Observatory, Austin, TX 78712 (United States)

    2015-02-01

    The reported positions of 964 suspected nova eruptions in M31 recorded through the end of calendar year 2013 have been compared in order to identify recurrent nova (RN) candidates. To pass the initial screen and qualify as a RN candidate, two or more eruptions were required to be coincident within 0.′1, although this criterion was relaxed to 0.′15 for novae discovered on early photographic patrols. A total of 118 eruptions from 51 potential RN systems satisfied the screening criterion. To determine what fraction of these novae are indeed recurrent, the original plates and published images of the relevant eruptions have been carefully compared. This procedure has resulted in the elimination of 27 of the 51 progenitor candidates (61 eruptions) from further consideration as RNe, with another 8 systems (17 eruptions) deemed unlikely to be recurrent. Of the remaining 16 systems, 12 candidates (32 eruptions) were judged to be RNe, with an additional 4 systems (8 eruptions) being possibly recurrent. It is estimated that ∼4% of the nova eruptions seen in M31 over the past century are associated with RNe. A Monte Carlo analysis shows that the discovery efficiency for RNe may be as low as 10% that for novae in general, suggesting that as many as one in three nova eruptions observed in M31 arise from progenitor systems having recurrence times ≲100 yr. For plausible system parameters, it appears unlikely that RNe can provide a significant channel for the production of Type Ia supernovae.

  1. Olivier Chesneau's Work on Novae

    Science.gov (United States)

    Millour, F.; Lagadec, E.

    2015-12-01

    Olivier Chesneau founded a brand new field of observational astrophysics with his attempts to resolve the novae expanding fireball from the very first days of the explosion. With the images he could get, he showed that novae do indeed explode in an aspherical way, leading to a change of paradigm for the physics of these yet-poorly understood catastrophic systems. He also set the stage for a new way of estimating novae distances, by directly measuring the sky-size of the fireball and comparing it with spectroscopic scales, taking into account the tremendous effects of the fireball geometry.

  2. Olivier Chesneau's work on novae

    CERN Document Server

    Millour, Florentin

    2016-01-01

    Olivier Chesneau founded a brand new field of observational astrophysics with his attempts to resolve the novae expanding fireball from the very first days of the explosion. With the images he could get, he showed that novae do indeed explode in an aspherical way, leading to a change of paradigm for the physics of these yet-poorly understood catastrophic systems. He also set the stage for a new way of estimating novae distances, by directly measuring the sky-size of the fireball and comparing it with spectroscopic scales, taking into account the tremendous effects of the fireball geometry.

  3. Recurrent Novae — A Review

    Directory of Open Access Journals (Sweden)

    K. Mukai

    2015-02-01

    Full Text Available In recent years, recurrent nova eruptions are often observed very intensely in wide range of wavelengths from radio to optical to X-rays. Here I present selected highlights from recent multi-wavelength observations. The enigma of T Pyx is at the heart of this paper. While our current understanding of CV and symbiotic star evolution can explain why certain subset of recurrent novae have high accretion rate, that of T Pyx must be greatly elevated compared to the evolutionary mean. At the same time, we have extensive data to be able to estimate how the nova envelope was ejected in T Pyx, and it turns to be a rather complex tale. One suspects that envelope ejection in recurrent and classical novae in general is more complicated than the textbook descriptions. At the end of the review, I will speculate that these two may be connected.

  4. Fermi Reveals New Light on Novae in Gamma rays

    CERN Document Server

    Cheung, C C; Shore, S N; Grove, J E; Leising, M

    2016-01-01

    Novae are now firmly established as a high-energy (>100 MeV) gamma-ray source class by the Fermi Large Area Telescope (LAT). In symbiotic binary systems such as V407 Cyg 2010, there is a firm theoretical framework for the production of shock-accelerated particles in the nova ejecta from interactions with the dense wind of the red giant companion. Yet, the high-energy gamma-ray emission detected in classical novae involving less evolved stellar companions cannot be explained in the same way and could instead be produced in internal shocks in the ejecta. We summarize the Fermi-LAT gamma-ray observations of novae, highlighting the main properties that will guide further studies. Additionally, we report on the soft gamma-ray (~0.1 MeV) continuum detection of the oxygen-neon type classical nova V382 Vel 1999 with the OSSE detector aboard the Compton Gamma Ray Observatory in light of its Fermi-era analog, V959 Mon 2012.

  5. Modelling nova populations in galaxies

    CERN Document Server

    Chen, Hai-Liang; Yungelson, L R; Gilfanov, M; Han, Zhanwen

    2016-01-01

    Theoretical modelling of the evolution of classical and recurrent novae plays an important role in studies of binary evolution, nucleosynthesis and accretion physics. However, from a theoretical perspective the observed statistical properties of novae remain poorly understood. In this paper, we have produced model populations of novae using a hybrid binary population synthesis approach for differing star formation histories (SFHs): a starburst case (elliptical-like galaxies), a constant star formation rate case (spiral-like galaxies) and a composite case (in line with the inferred SFH for M31). We found that the nova rate at 10\\;Gyr in an elliptical-like galaxy is $\\sim 10-20$ times smaller than a spiral-like galaxy with the same mass. The majority of novae in elliptical-like galaxies at the present epoch are characterized by low mass white dwarfs (WDs), long decay times, relatively faint absolute magnitudes and long recurrence periods. In contrast, the majority of novae in spiral-like galaxies at 10\\;Gyr hav...

  6. A custom microarray platform for analysis of microRNA gene expression.

    Science.gov (United States)

    Thomson, J Michael; Parker, Joel; Perou, Charles M; Hammond, Scott M

    2004-10-01

    MicroRNAs are short, noncoding RNA transcripts that post-transcriptionally regulate gene expression. Several hundred microRNA genes have been identified in Caenorhabditis elegans, Drosophila, plants and mammals. MicroRNAs have been linked to developmental processes in C. elegans, plants and humans and to cell growth and apoptosis in Drosophila. A major impediment in the study of microRNA function is the lack of quantitative expression profiling methods. To close this technological gap, we have designed dual-channel microarrays that monitor expression levels of 124 mammalian microRNAs. Using these tools, we observed distinct patterns of expression among adult mouse tissues and embryonic stem cells. Expression profiles of staged embryos demonstrate temporal regulation of a large class of microRNAs, including members of the let-7 family. This microarray technology enables comprehensive investigation of microRNA expression, and furthers our understanding of this class of recently discovered noncoding RNAs.

  7. Four unusual novae observed in Torun: V2362 Cyg, V2467 Cyg, V458 Vul, V2491 Cyg

    CERN Document Server

    Ragan, E; Tomov, T; Dimitrow, W; Fagas, M; Kwiatkowski, T; Schwarzenberg-Czerny, A; Buil, Ch; Swierczynski, E; Brozek, T; Cikala, M; Czart, K; Fidos, A; Frackowiak, S; Galan, C; Karska, A; Klosinska, M; Lewandowski, M; Radomski, T; Rozanski, P; Wiecek, M; Wychudzki, P; Zajczyk, A; Zielinska, M

    2010-01-01

    We present photometric and spectral observation for four novae: V2362 Cyg, V2467 Cyg, V458 Vul, V2491 Cyg. All objects belongs to the "fast novae" class. For these stars we observed different departures from a typical behavior in the light curve and spectrum.

  8. MicroRNAs, cancer and ionizing radiation: Where are we?

    Directory of Open Access Journals (Sweden)

    Gustavo Nader Marta

    2015-06-01

    Full Text Available Summary The aim of this study is to describe the biogenesis of microRNA, its relations with carcinogenesis, and the correlation between microRNA and ionizing radiation (IR, focusing on radioresponsiveness. It is known that microRNA biogenesis is well established and involves different enzymatic cleavages, resulting in the production of mature microRNA. MicroRNAs are involved in carcinogenesis. Their interaction is related to the genetic and epigenetic changes associated with activation of proto-oncogenes or inactivation of tumor suppressor genes. Several studies have shown that the levels of expression of some microRNAs vary significantly after irradiation. There are evidences that microRNAs can influence cellular response after IR. In addition, microRNAs are related to modulation of the expression of several post-transcriptional targets in DNA damage response pathways, and to the DNA damage repair regulation mechanism. Future studies can clarify a possible clinical use of microRNAs as a new class of radiosensitive agents.

  9. A nova ordem repressiva

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Ceccarelli

    Full Text Available Segundo o autor, a humanidade sempre foi marcada por alguma forma de controle de acordo com o discurso do momento sociohistórico que atravessa: esse texto discute alguns instrumentos de controle e repressão da contemporaneidade. Se, por séculos, foi a religião que ditou as normas sociais, na modernidade, as verdades religiosas foram substituídas por enunciados científicos que sugeriam uma linearidade histórica e propunham uma compreensão determinista do mundo, baseada na capacidade da ciência em dar respostas. As certezas da modernidade foram radicalmente questionadas na pósmodernidade, fazendo surgir outros mecanismos de controle. Para o autor, a necessidade do ser humano de criar representações e dispositivos para suportar e nomear a angústia inerente ao desamparo que lhe é próprio o leva a submeter-se aos mais variados discursos repressivos. O discurso científico atual vem sendo transformado em instrumento ideológico que, com as inúmeras expressões do politicamente correto, traduzem uma busca de normatização e de padronização de comportamentos, gerando uma nova ordem repressiva. No que diz respeito à saúde psíquica, os manuais de diagnóstico, financiados pela indústria farmacêutica, transformam comportamentos, individualidades e diversidades em patologias: as singularidades tornam-se anormalidades. Qual é o compromisso social dos psicólogos nesse debate?

  10. Nova LMC 1990 no. 1: The first extragalactic neon nova

    Science.gov (United States)

    Sonneborn, George; Shore, Steven N.; Starrfield, Sumner G.

    1990-01-01

    International Ultraviolet Explorer (IUE) observations of nova LMC (Large Magellanic Cloud) 1990 No. 1, the first neon (or ONeMg) nova observed outside the Galaxy are presented. The observations were obtained from 17 Jan. to Mar. 1990, with especially dense coverage during the first 25 days of the outburst. (The neon nova categorization is based on the detection of forbidden Ne 3-4 lines in optical spectra; the ultraviolet neon lines were not detected.) During the first 30 days of the outburst, the radiative losses were dominated by the N 5 delta 1240 and C 4 delta 1550 lines. The maximum ejection velocity was approximately 8000 km/s, based on the blue absorption edge of the C 4 P-Cygni profile. Early in the outburst of Nova LMC 1990 No. 1 the UV luminosity alone was approximately 3 times 10 to the 38th power erg/sec, implying that the bolometric luminosity was well in excess of the Eddington luminosity for a one solar mass object.

  11. MicroRNA and gynecological reproductive diseases.

    Science.gov (United States)

    Santamaria, Xavier; Taylor, Hugh

    2014-06-01

    MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies.

  12. Status for CASA NOVA konsortiet

    DEFF Research Database (Denmark)

    Bonke, Sten

    1997-01-01

    The report reviews the development projects and the results hitherto achieved by the design and build organisation CASA NOVA which is one of four consortia within the R&D programme "Process and Product Development in Building", financed by the Ministry of Industry and the Ministry of Housing....

  13. Status for CASA NOVA konsortiet

    DEFF Research Database (Denmark)

    Bonke, Sten

    1997-01-01

    The report reviews the development projects and the results hitherto achieved by the design and build organisation CASA NOVA which is one of four consortia within the R&D programme "Process and Product Development in Building", financed by the Ministry of Industry and the Ministry of Housing....

  14. Novae in gamma-rays

    CERN Document Server

    Hernanz, M

    2013-01-01

    Classical novae produce radioactive nuclei which are emitters of gamma-rays in the MeV range. Some examples are the lines at 478 and 1275 keV (from 7Be and 22Na) and the positron-electron annihilation emission (511 keV line and a continuum below this energy, with a cut-off at 20-30 keV). The analysis of gamma-ray spectra and light curves is a potential unique and powerful tool both to trace the corresponding isotopes and to give insights on the properties of the expanding envelope determining its transparency. Another possible origin of gamma-rays is the acceleration of particles up to very high energies, so that either neutral pions or inverse Compton processes produce gamma-rays of energies larger than 100 MeV. MeV photons during nova explosions have not been detected yet, although several attempts have been made in the last decades; on the other hand, GeV photons from novae have been detected in some particular novae, in symbiotic binaries, where the companion is a red giant with a wind, instead of a main ...

  15. MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality

    Directory of Open Access Journals (Sweden)

    Giordano Antonio

    2011-09-01

    Full Text Available Abstract There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small regulatory RNA molecules controls developmental programs by modulating gene expression through post-transcriptional silencing of target mRNAs. During myogenesis, muscle-specific and ubiquitously-expressed microRNAs tightly control muscle tissue differentiation. In recent years, microRNAs have emerged as prominent players in cancer as well. Rhabdomyosarcoma is a pediatric skeletal muscle-derived soft-tissue sarcoma that originates from myogenic precursors arrested at different stages of differentiation and that continue to proliferate indefinitely. MicroRNAs involved in muscle cell fate determination appear down-regulated in rhabdomyosarcoma primary tumors and cell lines compared to their normal counterparts. More importantly, they behave as tumor suppressors in this malignancy, as their re-expression is sufficient to restore the differentiation capability of tumor cells and to prevent tumor growth in vivo. In addition, up-regulation of pro-oncogenic microRNAs has also been recently detected in rhabdomyosarcoma. In this review, we provide an overview of current knowledge on microRNAs de-regulation in rhabdomyosarcoma. Additionally, we examine the potential of microRNAs as prognostic and diagnostic markers in this soft-tissue sarcoma, and discuss possible therapeutic applications and challenges of a "microRNA therapy".

  16. MicroRNAs as potential therapeutics for treating spinal cord injury

    Institute of Scientific and Technical Information of China (English)

    Hualin Yan; Peiwei Hong; Mei Jiang; Hedong Li

    2012-01-01

    MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

  17. Functional microRNA screening using a comprehensive lentiviral human microRNA expression library

    NARCIS (Netherlands)

    Poell, J.B.; van Haastert, R.J.; Cerisoli, F.; Bolijn, A.S.; Timmer, L.M.; Diosdado-Calvo, B.; Meijer, G.A.; van Puijenbroek, A.A.; Berezikov, E.; Schaapveld, R.Q.; Cuppen, E.

    2011-01-01

    ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) are a class of small regulatory RNAs that target sequences in messenger RNAs (mRNAs) to inhibit their protein output. Dissecting the complexities of miRNA function continues to prove challenging as miRNAs are predicted to have thousands of targets, and mRNAs

  18. AT Cnc: A SECOND DWARF NOVA WITH A CLASSICAL NOVA SHELL

    Energy Technology Data Exchange (ETDEWEB)

    Shara, Michael M.; Mizusawa, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024-5192 (United States); Wehinger, Peter [Steward Observatory, the University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Martin, Christopher D.; Neill, James D.; Forster, Karl [Department of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Mail Code 405-47, Pasadena, CA 91125 (United States); Seibert, Mark [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2012-10-20

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented 'shell', 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of {approx}5 Multiplication-Sign 10{sup -5} M {sub Sun }, typical of classical novae.

  19. Identifying and Quantifying Recurrent Novae Masquerading as Classical Novae

    CERN Document Server

    Pagnotta, Ashley

    2014-01-01

    Recurrent novae (RNe) are cataclysmic variables with two or more nova eruptions within a century. Classical novae (CNe) are similar systems with only one such eruption. Many of the so-called 'CNe' are actually RNe for which only one eruption has been discovered. Since RNe are candidate Type Ia supernova progenitors, it is important to know whether there are enough in our galaxy to provide the supernova rate, and therefore to know how many RNe are masquerading as CNe. To quantify this, we collected all available information on the light curves and spectra of a Galactic, time-limited sample of 237 CNe and the 10 known RNe, as well as exhaustive discovery efficiency records. We recognize RNe as having (a) outburst amplitude smaller than 14.5 - 4.5 * log(t_3), (b) orbital period >0.6 days, (c) infrared colors of J-H > 0.7 mag and H-K > 0.1 mag, (d) FWHM of H-alpha > 2000 km/s, (e) high excitation lines, such as Fe X or He II near peak, (f) eruption light curves with a plateau, and (g) white dwarf mass greater tha...

  20. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms

    Directory of Open Access Journals (Sweden)

    Davis Brandi N

    2009-08-01

    Full Text Available Abstract microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.

  1. AT Cnc: A Second Dwarf Nova with a Classical Nova Shell

    CERN Document Server

    Shara, Michael M; Wehinger, Peter; Zurek, David; Martin, Christopher D; Neill, James D; Forster, Karl; Seibert, Mark

    2012-01-01

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented "shell", 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [NII] emission. Galex FUV imagery reveals a ...

  2. Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.

    Science.gov (United States)

    Shen, Tian; Sanchez, Helia N; Zan, Hong; Casali, Paolo

    2015-01-01

    As we have suggested, epigenetic factors, such as microRNAs (miRNAs), can interact with genetic programs to regulate B cell functions, thereby informing antibody and autoantibody responses. We have shown that histone deacetylase (HDAC) inhibitors (HDI) inhibit the differentiation events critical to the maturation of the antibody response: class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, by modulating intrinsic B cell mechanisms. HDI repress the expression of AID and Blimp-1, which are critical for CSR/SHM and plasma cell differentiation, respectively, in mouse and human B cells by upregulating selected miRNAs that silenced AICDA/Aicda and PRDM1/Prdm1 mRNAs, as demonstrated by multiple qRT-PCRs (J Immunol 193:5933-5950, 2014). To further define the selectivity of HDI-mediated modulation of miRNA and gene expression, we performed genome-wide miRNA-Seq and mRNA-Seq analysis in B cells stimulated by LPS plus IL-4 and treated with HDI or nil. Consistent with what we have shown using qRT-PCR, these HDI-treated B cells displayed reduced expression of Aicda and Prdm1, and increased expression of miR-155, miR-181b, and miR-361, which target Aicda, and miR-23b, miR-30a, and miR-125b, which target Prdm1. In B cells induced to undergo CSR and plasma cell differentiation, about 23% of over 22,000 mRNAs analyzed were expressed at a significantly high copy number (more than 20 copies/cell). Only 18 (0.36%) of these highly expressed mRNAs, including Aicda, Prdm1, and Xbp1, were downregulated by HDI by 50% or more. Further, only 16 (0.30%) of the highly expressed mRNAs were upregulated (more than twofold) by HDI. The selectivity of HDI-mediated modulation of gene expression was emphasized by unchanged expression of the genes that are involved in regulation, targeting, or DNA repair processes of CSR, as well as unchanged expression of the genes encoding epigenetic regulators and factors that are important for cell signaling or

  3. Genome-wide analysis reveals selective modulation of microRNAs and mRNAs by histone deacetylase inhibitor in B cells induced to undergo class switch DNA recombination and plasma cell differentiation

    Directory of Open Access Journals (Sweden)

    Tian eShen

    2015-12-01

    Full Text Available As we have suggested, epigenetic factors, such as microRNAs (miRNAs, can interact with genetic programs to regulate B cell functions, thereby informing antibody and autoantibody responses. We have shown that histone deacetylase inhibitors (HDI inhibit the differentiation events critical to the maturation of the antibody response: class-switch DNA recombination (CSR, somatic hypermutation (SHM and plasma cell differentiation, by modulating intrinsic B cell mechanisms. HDI repress the expression of AID and Blimp-1, which are critical for CSR/SHM and plasma cell differentiation, respectively, in mouse and human B cells by upregulating selected miRNAs that silenced AICDA/Aicda and PRDM1/Prdm1 mRNAs, as demonstrated by multiple qRT-PCRs (J. Immunol. 193:5933-5950, 2014. To further define the selectivity of HDI-mediated modulation of miRNA and gene expression, we performed genome-wide miRNA-Seq and mRNA-Seq analysis in B cells stimulated by LPS plus IL-4 and treated with HDI or nil. Consistent with what we have shown using qRT-PCR, these HDI-treated B cells displayed reduced expression of Aicda and Prdm1, and increased expression of miR-155, miR-181b and miR-361, which target Aicda, and miR-23b, miR-30a and miR-125b, which target Prdm1. In B cells induced to undergo CSR and plasma cell differentiation, about 23% of over 22,000 mRNAs analyzed were expressed at a significantly high copy number (more than 20 copies/cell. Only 18 (0.36% of these highly expressed mRNAs, including Aicda, Prdm1 and Xbp1, were downregulated by HDI by 50% or more. Further, only 16 (0.30% of the highly expressed mRNAs were upregulated (more than twofold by HDI. The selectivity of HDI-mediated modulation of gene expression was emphasized by unchanged expression of the genes that are involved in regulation, targeting or DNA repair processes of CSR, as well as unchanged expression of the genes encoding epigenetic regulators and factors that are important for cell signaling or

  4. Nova Scotia offshore renewal plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-10-15

    Increase in global exploration and production have caused a reduction in offshore exploration licences. This paper outlined the government of Nova Scotia's offshore renewal plan. The plan was designed to clarify the role of the government and the Canada-Nova Scotia Offshore Petroleum Board (CNSOPB) and federal government. The plan was comprised of 4 different sections, including (1) geoscience, (2) new policy, (3) regulation, and (4) investment abstraction. Requests for proposals are now being designed to develop a better understanding of the geology of offshore Nova Scotia, including the shelf slope and deep water areas in the vicinity of Sable Island. A code of practice is currently being developed to minimize the impact of resource development on the marine environment while supporting the economic development of smaller oil and gas discoveries. Resource and analysis packages are currently being developed to help investors compute the risks associated with developing offshore sites. It was concluded that early action is required to address challenges and knowledge gaps related to geological data, regulatory efficiency, policy, and marketing strategies. Success of the plan will require the continued cooperation, and support of various governmental agencies. Details of regulatory renewal initiative projects were included. 1 fig.

  5. Erupting Dwarf Novae in the Large Magellanic Cloud

    CERN Document Server

    Shara, M M; Zurek, D R; Shara, Michael M.; Hinkley, Sasha; Zurek, David R.

    2003-01-01

    We report the first likely detections of erupting Dwarf Novae (DN) in an external galaxy: the Large Magellanic Cloud. Six candidates were isolated from approximately a million stars observed every second night over 11 nights with the CTIO 8K x 8K Mosaic2 CCD imager. Artificial dwarf nova and completeness tests suggest that we are seeing only the brightest of the LMC DN, probably SS Cygni-like CVs, but possibly SU UMa-type cataclysmics undergoing superoutbursts. We derive crude but useful limits on the LMC DN surface density, and on the number of DN in the LMC. Many thousands of cataclysmic variables in the Magellanic Clouds can be discovered and characterized with 8 meter class telescopes.

  6. MicroRNAs

    DEFF Research Database (Denmark)

    Devaux, Yvan; Stammet, Pascal; Friberg, Hans

    2015-01-01

    cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential...... biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may...

  7. MicroRNA gene expression in malignant lymphoproliferative disorders

    Institute of Scientific and Technical Information of China (English)

    XU Wei; LI Jian-yong

    2007-01-01

    Objective To review the recent studies about microRNAs and advances in malignant lymphoproliferative disorders.Data sources Published articles (2001-2006) about microRNAs and malignant iymphoproliferative disorders were selected using MEDLINE.Study selection After independent review by two observers, 43 of 421 originally identified articles were selected that specifically addressed the stated purpose.Results Two observers independently assessed studies using explicit methodological criteria for evaluating microRNAs in malignant lymphoproliferative disorders. Recent work has revealed a class of small noncoding RNA species,microRNAs, which affect various biological processes. MicroRNAs inhibit the expression of protein encoding genes at the posttranscriptional level in a variety of eukaryotic organisms. In this review, we focused on the biogenetic pathways of microRNAs (miR-15a, miR-16-1, miR-155, miR-17-92 cluster, miR-142) and discussed the implications for human malignant lymphoproliferative disorders.Conclusions microRNAs are involved in tumorigenesis and mediate gene regulation as a fundamental genetic program at the posttranscriptional level. Further study of microRNAs may lead to novel concepts in the diagnosis and treatment of malignant lymphoproliferative disorders.

  8. MicroRNA signatures in liver diseases

    OpenAIRE

    Chen, Xian-Ming

    2009-01-01

    MicroRNAs (miRNAs) are an emerging class of highly conserved non-coding small RNAs that regulate gene expression at the post-transcriptional level. It is now clear that miRNAs can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorigenesis. Recent studies provide clear evidence that miRNAs are abundant in the liver and modulate a diverse spectrum of liver functions. Deregu...

  9. MicroRNAs as Novel Regulators of Neuroinflammation

    Directory of Open Access Journals (Sweden)

    Dominika Justyna Ksiazek-Winiarek

    2013-01-01

    Full Text Available MicroRNAs are relatively recently discovered class of small noncoding RNAs, which function as important regulators of gene expression. They fine-tune protein expression either by translational inhibition or mRNA degradation. MicroRNAs act as regulators of diverse cellular processes, such as cell differentiation, proliferation, and apoptosis. Their defective biogenesis or function has been identified in various pathological conditions, like inflammation, neurodegeneration, or autoimmunity. Multiple sclerosis is one of the predominated debilitating neurological diseases affecting mainly young adults. It is a multifactorial disorder of as yet unknown aetiology. As far, it is suggested that interplay between genetic and environmental factors is responsible for MS pathogenesis. The role of microRNAs in this pathology is now extensively studied. Here, we want to review the current knowledge of microRNAs role in multiple sclerosis.

  10. Predicting a Luminous Red Nova

    Science.gov (United States)

    Van Noord, Daniel; Molnar, Larry; Kinemuchi, Karen; Steenwyk, Steven; Alexander, Cara; Spedden, Chris; Kobulnicky, Henry

    2016-05-01

    Luminous Red Novae (LRN) are rare transient events believed to be caused by the merger of a main sequence contact binary. Since the discovery of the prototype, V838 Mon, only a handful of LRN events have been observed. Tylenda et al. (2011) analyzed the OGLE data preceding the 2008 Novae of V1309 Sco and found that it exhibited a similar light curve to that of a contact binary with one interesting exception, the orbital period of V1309 Sco showed exponential period change going to zero. Unfortunately the system was discovered to be a binary after the merger, preventing any targeted observations to narrow down how the system entered this unusual state. However the extreme period change observed in V1309 Sco gives us a signature to look for in other contact binaries, allowing the discovery of merger candidates for follow up. We will present an analysis of light curves and spectra of KIC 9832227 (NSVS 5597755) that show it is a contact binary system with a negative period derivative that is becoming more extreme with time. These data span more than 15 years and are taken from the NSVS, ASAS, WASP, and Kepler surveys, with ongoing measurements from the Calvin College Observatory and the Apache Point Observatory. The ongoing period change observed in the system is consistent with the exponential model fit from V1309 Sco and the rate of period change has surpassed that of all other measured contact binaries with the exception of V1309 Sco. If the exponential period decay continues the system will likely merge between 2019 and 2022 resulting in a naked eye nova. If this event occurs, this star will present the unprecedented opportunity to study a LRN progenitor and to follow the evolution of the merger.

  11. V5852 Sgr: An Unusual Nova Possibly Associated with the Sagittarius Stream

    CERN Document Server

    Aydi, E; Whitelock, P A; Mohamed, S; Wyrzykowski, Ł; Udalski, A; Vaisanen, P; Nagayama, T; Dominik, M; Scholz, A; Onozato, H; Williams, R E; Hodgkin, S T; Nishiyama, S; Yamagishi, M; Smith, A M S; Ryu, T; Iwamatsu, A; Kawamata, I

    2016-01-01

    We report spectroscopic and photometric follow-up of the peculiar nova V5852~Sgr (discovered as OGLE-2015-NOVA-01), which exhibits a combination of features from different nova classes. The photometry shows a flat-topped light curve with quasi-periodic oscillations, then a smooth decline followed by two fainter recoveries in brightness. Spectroscopy with the Southern African Large Telescope shows first a classical nova with an Fe II or Fe IIb spectral type. In the later spectrum, broad emissions from helium, nitrogen and oxygen are prominent and the iron has faded which could be an indication to the start of the nebular phase. The line widths suggest ejection velocities around $1000\\,{\\rm km\\,s^{-1}}$. The nova is in the direction of the Galactic bulge and is heavily reddened by an uncertain amount. The $V$ magnitude 16 days after maximum enables a distance to be estimated and this suggests that the nova may be in the extreme trailing stream of the Sagittarius dwarf spheroidal galaxy. If so it is the first no...

  12. A transitoriedade: uma nova leitura

    Directory of Open Access Journals (Sweden)

    José Otávio de Vasconcellos Naves

    2008-12-01

    Full Text Available Neste trabalho, o texto de Freud Vergänglichkeit (1916 ganha uma nova perspectiva: é a consciência, transitória, que se ocupa do importante intercâmbio entre o eu e o mundo. Entretanto, ela e a sua transitoriedade adoecem. Na paranóia, ela se perde num futuro aterrador para se reencontrar numa realidade delirante. Na melancolia, a consciência se perde no passado, exaurindo-se na reconstituição de um objeto de desejo impossível de ser considerado como perdido.

  13. Near-infrared studies of V2944 Ophiuchi (Nova Ophiuchi 2015)

    Science.gov (United States)

    Srivastava, Mudit K.; Banerjee, D. P. K.; Ashok, N. M.; Venkataraman, V.; Sand, D.; Diamond, T.

    2016-10-01

    We present multi-epoch near-infrared observations of Nova Ophiuchi 2015 which was discovered during outburst in March 2015. This nova showed a few special properties viz. (i) it displayed an unusual prolonged flat-top light curve which does not easily fit into known classes of nova light curves, (ii) it showed evidence for possessing an evolved secondary in the outbursting binary system, and (iii) it made a rare reverse hybrid transition from the He/N class to Fe II class early during its outburst. The present studies focus on the spectroscopic evolution of the object around maximum light and early decline. We show that there was a unique, rapid strengthening and decline in the He 1.0831, 2.0581 μm line strengths during this stage, wherein the nova combined the traits of both the He/N and Fe II classes. Possible causes for this behaviour are discussed. The relative strengths of the Lyβ fluoresced O I 0.8446, 1.1287 μm lines are used to estimate the reddening to the nova. A recombination Case B analysis of the early spectra is used to set constraints on the electron density and emission measure, and a later time spectrum when the ejecta were optically thin is used to estimate the ejecta mass to be (0.95-1.9) × 10-4 M⊙. Power-law fits made to study the evolution of the continuum, show a fairly constant slope which differs from the trend generally expected during a nova's evolution viz. beginning with a blackbody and evolving to a free-free distribution at later stages.

  14. On the Progenitors of Galactic Novae

    CERN Document Server

    Darnley, M J; Bode, M F; Hounsell, R A; Williams, R P

    2011-01-01

    Of the approximately 400 known Galactic classical novae, only ten of them, the recurrent novae, have been seen to erupt more than once. At least eight of these recurrents are known to harbor evolved secondary stars, rather than the main sequence secondaries typical in classical novae. In this paper, we propose a new nova classification system, based solely on the evolutionary state of the secondary, and not (like the current schemes) based on the properties of the outbursts. Using archival optical and near-infrared photometric observations of a sample of thirty eight quiescent Galactic novae we show that the evolutionary state of the secondary star in a quiescent system can predicted and several objects are identified for follow-up observations; CI Aql, V2487 Oph, DI Lac and EU Sct.

  15. Language Awareness in Nova Scotia Schools: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    David Piper

    2010-05-01

    Full Text Available The author conducted a questionnaire survey of language awareness in 358 students studying in Grades 8, 10, and 12 English classes in three rural and three urban schools in Nova Scotia. The main objectives of the study were to learn just how sensitive these students were to key aspects of language prior to any deliberate instruction in language awareness, to obtain new information about levels of natural language awareness as the basis for curriculum development, to uncover significant subject variables in relation to developing language awareness, and to clarify the theoretical distinction between “ordinary” and “critical” language awareness.

  16. Changes and Possibilities: A Case Study of Nova Scotia Classroom Assessment Policies

    Science.gov (United States)

    Van Zoost, Steven

    2011-01-01

    Although numerous writers have identified a different set of skills needed for employment in New Times, little analytic attention has been paid to how educational assessment policies contribute to envisioning such future citizens. This case study illustrates how Nova Scotia classroom assessment policy for Grades 7-9 English classes envisions young…

  17. RZ Leonis Minoris bridging between ER Ursae Majoris-type dwarf nova and nova-like system

    Science.gov (United States)

    Kato, Taichi; Ishioka, Ryoko; Isogai, Keisuke; Kimura, Mariko; Imada, Akira; Miller, Ian; Masumoto, Kazunari; Nishino, Hirochika; Kojiguchi, Naoto; Kawabata, Miho; Sakai, Daisuke; Sugiura, Yuki; Furukawa, Hisami; Yamamura, Kenta; Kobayashi, Hiroshi; Matsumoto, Katsura; Wang, Shiang-Yu; Chou, Yi; Ngeow, Chow-Choong; Chen, Wen-Ping; Panwar, Neelam; Lin, Chi-Sheng; Hsiao, Hsiang-Yao; Guo, Jhen-Kuei; Lin, Chien-Cheng; Omarov, Chingis; Kusakin, Anatoly; Krugov, Maxim; Starkey, Donn R.; Pavlenko, Elena P.; Antonyuk, Kirill A.; Sosnjvskij, Aleksei A.; Antonyuk, Oksana I.; Pit, Nikolai V.; Baklanov, Alex V.; Babina, Julia V.; Itoh, Hiroshi; Padovan, Stefano; Akazawa, Hidehiko; Kafka, Stella; de Miguel, Enrique; Pickard, Roger D.; Kiyota, Seiichiro; Shugarov, Sergey Yu.; Chochol, Drahomir; Krushevska, Viktoriia; Sekeráš, Matej; Pikalova, Olga; Sabo, Richard; Dubovsky, Pavol A.; Kudzej, Igor; Ulowetz, Joseph; Dvorak, Shawn; Stone, Geoff; Tordai, Tamás; Dubois, Franky; Logie, Ludwig; Rau, Steve; Vanaverbeke, Siegfried; Vanmunster, Tonny; Oksanen, Arto; Maeda, Yutaka; Kasai, Kiyoshi; Katysheva, Natalia; Morelle, Etienne; Neustroev, Vitaly V.; Sjoberg, George

    2016-12-01

    We observed RZ LMi, which is renowned for its extremely short (˜19 d) supercycle and is a member of a small, unusual class of cataclysmic variables called ER UMa-type dwarf novae, in 2013 and 2016. In 2016, the supercycles of this object substantially lengthened in comparison to the previous measurements to 35, 32, and 60 d for three consecutive superoutbursts. We consider that the object virtually experienced a transition to the nova-like state (permanent superhumper). This observed behavior reproduced the prediction of the thermal-tidal instability model extremely well. We detected a precursor in the 2016 superoutburst and detected growing (stage A) superhumps with a mean period of 0.0602(1) d in 2016 and in 2013. Combined with the period of superhumps immediately after the superoutburst, the mass ratio is not as small as in WZ Sge-type dwarf novae, having orbital periods similar to RZ LMi. By using least absolute shrinkage and selection operator (Lasso) two-dimensional power spectra, we detected possible negative superhumps with a period of 0.05710(1) d. We estimated an orbital period of 0.05792 d, which suggests a mass ratio of 0.105(5). This relatively large mass ratio is even above that of ordinary SU UMa-type dwarf novae, and it is also possible that the exceptionally high mass-transfer rate in RZ LMi may be a result of a stripped secondary with an evolved core in a system evolving toward an AM CVn-type object.

  18. The NOvA Technical Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Ayres, D.S.; Drake, G.R.; Goodman, M.C.; Grudzinski, J.J.; Guarino, V.J.; Talaga, R.L.; Zhao, A.; /Argonne; Stamoulis, P.; Stiliaris, E.; Tzanakos, G.; Zois, M.; /Athens U. /Caltech /UCLA /Fermilab /College de France /Harvard U. /Indiana U. /Lebedev Inst. /Michigan State U. /Minnesota U., Duluth /Minnesota U.

    2007-10-08

    Technical Design Report (TDR) describes the preliminary design of the NOvA accelerator upgrades, NOvA detectors, detector halls and detector sites. Compared to the March 2006 and November 2006 NOvA Conceptual Design Reports (CDR), critical value engineering studies have been completed and the alternatives still active in the CDR have been narrowed to achieve a preliminary technical design ready for a Critical Decision 2 review. Many aspects of NOvA described this TDR are complete to a level far beyond a preliminary design. In particular, the access road to the NOvA Far Detector site in Minnesota has an advanced technical design at a level appropriate for a Critical Decision 3a review. Several components of the accelerator upgrade and new neutrino detectors also have advanced technical designs appropriate for a Critical Decision 3a review. Chapter 1 is an Executive Summary with a short description of the NOvA project. Chapter 2 describes how the Fermilab NuMI beam will provide a narrow band beam of neutrinos for NOvA. Chapter 3 gives an updated overview of the scientific basis for the NOvA experiment, focusing on the primary goal to extend the search for {nu}{sub {mu}} {yields} {nu}{sub e} oscillations and measure the sin{sup 2}(2{theta}{sub 13}) parameter. This parameter has not been measured in any previous experiment and NOvA would extend the search by about an order of magnitude beyond the current limit. A secondary goal is to measure the dominant mode oscillation parameters, sin{sup 2}(2{theta}{sub 23}) and {Delta}m{sub 32}{sup 2} to a more precise level than previous experiments. Additional physics goals for NOvA are also discussed. Chapter 4 describes the Scientific Design Criteria which the Fermilab accelerator complex, NOvA detectors and NOvA detector sites must satisfy to meet the physics goals discussed in Chapter 3. Chapter 5 is an overview of the NOvA project. The changes in the design relative to the NOvA CDR are discussed. Chapter 6 summarizes the NOvA

  19. Searching for nova shells around cataclysmic variables

    CERN Document Server

    Sahman, D I; Knigge, C; Marsh, T R

    2015-01-01

    We present the results of a search for nova shells around 101 cataclysmic variables (CVs), using Halpha images taken with the 4.2-m William Herschel Telescope (WHT) and the 2.5-m Isaac Newton Telescope Photometric Halpha Survey of the Northern Galactic Plane (IPHAS). Both telescopes are located on La Palma. We concentrated our WHT search on nova-like variables, whilst our IPHAS search covered all CVs in the IPHAS footprint. We found one shell out of the 24 nova-like variables we examined. The newly discovered shell is around V1315 Aql and has a radius of approx.2.5 arcmin, indicative of a nova eruption approximately 120 years ago. This result is consistent with the idea that the high mass-transfer rate exhibited by nova-like variables is due to enhanced irradiation of the secondary by the hot white dwarf following a recent nova eruption. The implications of our observations for the lifetime of the nova-like variable phase are discussed. We also examined 4 asynchronous polars, but found no new shells around an...

  20. Classical novae from the POINT-AGAPE microlensing survey of M31 -- I. The nova catalogue

    CERN Document Server

    Darnley, Matt J.; Kerins, E.; Newsam, A.M.; An, J.; Baillon, P.; Calchi Novati, S.; Carr, Bernard J.; Creze, M.; Evans, N.W.; Giraud-Heraud, Y.; Gould, A.; Hewett, Paul C.; Jetzer, Ph.; Kaplan, J.; Paulin-Henriksson, S.; Smartt, S.J.; Stalin, C.S.; Tsapras, Y.

    2004-01-01

    The POINT-AGAPE survey is an optical search for gravitational microlensing events towards the Andromeda Galaxy (M31). As well as microlensing, the survey is sensitive to many different classes of variable stars and transients. Here we describe the automated detection and selection pipeline used to identify M31 classical novae (CNe) and we present the resulting catalogue of 20 CN candidates observed over three seasons. CNe are observed both in the bulge region as well as over a wide area of the M31 disk. Nine of the CNe are caught during the final rise phase and all are well sampled in at least two colours. The excellent light-curve coverage has allowed us to detect and classify CNe over a wide range of speed class, from very fast to very slow. Among the light-curves is a moderately fast CN exhibiting entry into a deep transition minimum, followed by its final decline. We have also observed in detail a very slow CN which faded by only 0.01 mag day$^{-1}$ over a 150 day period. We detect other interesting varia...

  1. Medium-band photometry of novae

    Energy Technology Data Exchange (ETDEWEB)

    Yao, B.A.; Mo, J.E.

    1975-06-01

    In the early stage of novae, the conventional method of photometric transformation is accepted. When the novae are in a nebular stage, one cannot assign the observed values as U, B, V, whether one reduces them by photometric transformation or not. A quantitative calculation was made by means of spectral datum. It proves that the result of the observation may lead to unexpected differences. Differential extinction also cannot be corrected by the conventional method. Some suggestions for better observation and reduction of novae photometry are given.

  2. microRNA

    OpenAIRE

    Xin, Xiong; Ning, Zhou

    2007-01-01

    MicroRNAs (miRNAs) are short, 20-22 nucleotide RNA molecules that function as negative regulators of gene expression in eukaryotic organisms. RNA mediated gene silencing pathways have essential roles in development, cell differentiation, proliferation, and cell death. It is becoming clear that microRNAs can play a very important role in regulation of gene expression. Understanding the basic mechanism of miRNA biogenesis is one of the central aims of molecular biologists in the future. MicroRN...

  3. MicroRNA networks direct neuronal development and plasticity

    NARCIS (Netherlands)

    Olde Loohuis, N.F.; Kos, A.; Martens, G.J.; Bokhoven, J.H.L.M. van; Nadif Kasri, N.; Aschrafi, A.

    2012-01-01

    MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal develo

  4. The Multifarious Hippocampal Functions of MicroRNA-137

    NARCIS (Netherlands)

    Kos, A.; Aschrafi, A.; Nadif Kasri, N.

    2016-01-01

    MicroRNAs (miRs) have emerged as a powerful class of endogenous noncoding RNAs involved in posttranscriptional gene expression regulation. miR-137 has repeatedly been associated with schizophrenia and intellectual disability. Recent studies describe the mechanisms of miR-137 in mediating basic synap

  5. The role of microRNA in nutritional control

    NARCIS (Netherlands)

    Nolte - t Hoen, Esther; Van Rooij, E.; Bushell, M.; Zhang, C. Y.; Dashwood, R. H.; James, W. P T; Harris, C.; Baltimore, D.

    2015-01-01

    MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs

  6. MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Shun; Huang, Haijiao; Li, Nanhong; Zhang, Bing; Jia, Yubin; Yang, Yukun; Yuan, Yuan; Xiong, Xing-dong; Wang, Dengchuan; Zheng, Hui-ling [Institute of Aging Research, Guangdong Medical University, Dongguan (China); Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan (China); Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang (China); Liu, Xinguang, E-mail: xgliu64@126.com [Institute of Aging Research, Guangdong Medical University, Dongguan (China); Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan (China); Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang (China)

    2016-05-13

    MicroRNAs are a large class of tiny noncoding RNAs, which have emerged as critical regulators of gene expression, and thus are involved in multiple cellular processes, including cellular senescence. MicroRNA-33 has previously been established to exert crucial effect on cell proliferation, lipid metabolism and cholesterol metabolism. Nonetheless, the association between microRNA-33 and cellular senescence and its underlying molecular mechanism are far to be elucidated. The present study has attempted to probe into the effect of microRNA-33 on MEFs senescence. Our data unveiled that microRNA-33 was dramatically down-regulated in senescent MEFs compared to the young MEFs, and ectopic expression of microRNA-33 promoted MEFs senescence, while knock-down of microRNA-33 exhibited a protective effect against senescence phenotype. Moreover, we verified CDK6 as a direct target of microRNA-33 in mouse. Silencing of CDK6 induced the premature senescence phenotype of MEFs similarly as microRNA-33, while enforced expression of CDK6 significantly reverse the senescence-induction effect of microRNA-33. Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression. -- Highlights: •MicroRNA-33 was dramatically down-regulated in senescent MEF cells. •Altered expression of microRNA-33 exerted a critical role in MEFs senescence. •MicroRNA-33 promoted the replicative senescence of MEFs via targeting of CDK6.

  7. Gendered and cultured relations: exploring African Nova Scotians' perceptions and experiences of breast and prostate cancer.

    Science.gov (United States)

    Evans, Joan; Butler, Lorna; Etowa, Josephine; Crawley, Iona; Rayson, Daniel; Bell, David G

    2005-01-01

    Although breast and prostate cancer are those most frequently diagnosed in Canada, information about the ways in which gender, class, race, culture, and other social determinants impact the experience of African Canadians living with cancer is lacking. This study began to address this gap by exploring cultured and gendered dimensions of African Nova Scotians' experiences of these two cancers. Using a participatory action research approach, data were collected in two phases of focus group discussions in five African Nova Scotian communities from a total of 57 people, including those with breast or prostate cancer and their families and associates. Findings provide insight into how gender and meanings of masculinity and femininity in the African Nova Scotian community unavoidably interact with other social structures such as race and class to affect women and men's perceptions and experiences of these two cancers. These insights point to the need for culturally appropriate and meaningful health interventions. As a prerequisite, health care professionals need to have an understanding of the overlapping and contextualized nature of gender, class, and race and be willing and able to work in partnership with African Nova Scotian communities to identify and develop strategies that reflect the realities of peoples' lives.

  8. An Emerging Wine Region in Nova Scotia, Canada: Terroir Trials and Tribulations

    Science.gov (United States)

    Cameron, B. I.; Ketter, B. S.; Karakis, S.

    2012-12-01

    Nova Scotia, strategically located on Canada's east coast, is an emerging wine region, whose distinctive wines are garnering international acclaim. Nova Scotia has a long and rich tradition of growing grapes for wine dating back as far as 1611. Nova Scotia's mesoclimates, glacial soils, and proximity to the Atlantic Ocean form a complex alliance to create a unique and expressive terroir. Tidal Bay is a new appellation wine for Nova Scotia stylistically defined as a fresh, crisp and high-acid blend of white grapes. There are four main wine-growing regions in Nova Scotia, all influenced by the warming effects of the Bay of Fundy and Atlantic Ocean: Malagash Peninsula, Annapolis Valley, Bear River Valley and the South Shore. Nova Scotia currently has 14 producing wineries with many more in the development stage. Nova Scotia grape growers not only have had success developing mature and consistent hybrids, but in recent years several vinifera have flourished in this cool climate area. The white hybrids include L'Acadie Blanc, New York Muscat, Seyval Blanc, and Vidal Blanc. The white vinifera include chardonnay, riesling, pinot gris, and sauvignon blanc. Red hybrids are Baco Noir, Leon Millet, Lucie Kuhlmann, and Marechal Foch, whereas the only red vinifera is pinot noir. Nova Scotia has nearly perfect climatic conditions for making world class icewines and sparkling wines. A preliminary GIS analysis of climate, topographic, geology and soil data helps to define Nova Scotia's terroir. Annual precipiatation varies from 10 to 21.6 cm/year with a vast majority of the wineries located in regions with the lowest rainfall. Daily average temperature ranges from 5.5 to 7.5°C, degree growing days above 5°C from 1382 to 1991, and mean August temperature from 15.6 to 19.3 °C. Wineries cluster in the warmest regions based on these temperature measures to assist grape ripening. Soils in these diverse wine regions can range from silty, sandy and clay loams to more gravel-rich sandy

  9. Infrared studies of Nova Scorpii 2014: an outburst in a symbiotic system sans an accompanying blast wave

    CERN Document Server

    Joshi, Vishal; Ashok, N M; Venkataraman, V; Walter, F M

    2015-01-01

    Near-IR spectroscopy is presented for Nova Scorpii 2014. It is shown that the outburst occurred in a symbiotic binary system - an extremely rare configuration for a classical nova outburst to occur in but appropriate for the eruption of a recurrent nova of the T CrB class. We estimate the spectral class of secondary as M5III $\\pm$ (two sub-classes). The maximum magnitude versus rate of decline (MMRD) relations give an unacceptably large value of 37.5 kpc for the distance. The spectra are typical of the He/N class of novae with strong HeI and H lines. The profiles are broad and flat topped with full width at zero intensities (FWZIs) approaching 9000-10000 km s$^{-1}$ and also have a sharp narrow component superposed which is attributable to emission from the giant's wind. Hot shocked gas, accompanied by X-rays and $\\gamma$ rays, is expected to form when the high velocity ejecta from the nova plows into the surrounding giant wind. Although X-ray emission was observed no $\\gamma$-ray emission was reported. It is...

  10. On Orbital Period Changes in Nova Outbursts

    CERN Document Server

    Martin, Rebecca G; Schaefer, Bradley E

    2011-01-01

    We propose a new mechanism that produces an orbital period change during a nova outburst. When the ejected material carries away the specific angular momentum of the white dwarf, the orbital period increases. A magnetic field on the surface of the secondary star forces a fraction of the ejected material to corotate with the star, and hence the binary system. The ejected material thus takes angular momentum from the binary orbit and the orbital period decreases. We show that for sufficiently strong magnetic fields on the surface of the secondary star, the total change to the orbital period could even be negative during a nova outburst, contrary to previous expectations. Accurate determinations of pre- and post-outburst orbital periods of recurrent nova systems could test the new mechanism, in addition to providing meaningful constraints on otherwise difficult to measure physical quantities. We apply our mechanism to outbursts of the recurrent nova U Sco.

  11. The Terra Nova oil field development

    Energy Technology Data Exchange (ETDEWEB)

    Bruce, G.C. [Petro-Canada, Inc., St. John' s, NF (Canada)

    2001-07-01

    Before expanding on the development of the Terra Nova oilfield, the author discussed the overall business strategy of Petro-Canada and identified where the Terra Nova and offshore Newfoundland oil have their place within this strategy. The principal basins and oilfields offshore Newfoundland were reviewed, then the emphasis shifted to rest on the Terra Nova development project. A whole range of topics were brought up, including the Floating Production, Storage and Offloading (FPSO) facility, the modules layout, the FPSO located at Bull Arm, and the floating production systems. The physical environment of the Grand Banks was highlighted, and the next few sections were devoted to the Terra Nova FPSO, FPSO and drill centres, the Turret General Arrangement, and Spider buoy including the disconnect/reconnect. The last four sections dealt with the animation of riser movement, the wellhead protection animation, Henry Goodrich, and operations readiness.

  12. Comparison of the NovaSom QSG, a new sleep apnea home-diagnostic system, and polysomnography.

    Science.gov (United States)

    Reichert, James A; Bloch, Daniel A; Cundiff, Elizabeth; Votteri, Bernhard A

    2003-05-01

    Obstructive sleep apnea (OSA) is a serious, common, and underdiagnosed disorder that challenges health care resources. While polysomnography (PSG) represents the standard diagnostic test for OSA, portable devices provide an alternative diagnostic tool when issues of cost, time, geographic availability, or other constraints pose impediments to in-lab testing. This study compares the NovaSom QSG, a new sleep apnea home diagnostic system, to PSG both in the laboratory and in the home. Fifty-one consecutive adults referred to the sleep lab for suspicion of OSA underwent one night of in-lab, simultaneous recording of PSG and NovaSom QSG in addition to using the NovaSom QSG at home for three nights. Two separate comparisons were made using the apnea-hypopnea index (AHI): in-lab PSG to in-lab NovaSom QSG and in-lab PSG to home NovaSom QSG. Using a clinical cut-off of AHI=15, the sensitivity and specificity of the in-lab NovaSom QSG vs. PSG were 95% and 91%, respectively. For home NovaSom QSG vs. in-lab PSG, the sensitivity was 91% and specificity was 83%. The intra-class correlation coefficient for the agreement between three separate nights of NovaSom QSG home data was 0.88. In a patient population suspected of having OSA, the NovaSom QSG demonstrated acceptable sensitivity and specificity both in the lab and self-administered in the home, when compared to PSG.

  13. The Effect of Composition on Nova Ignitions

    CERN Document Server

    Shen, Ken J

    2008-01-01

    The accretion of hydrogen-rich matter onto C/O and O/Ne white dwarfs in binary systems leads to unstable thermonuclear ignition of the accreted envelope, triggering a convective thermonuclear runaway and a subsequent classical, recurrent, or symbiotic nova. Prompted by uncertainties in the composition at the base of the accreted envelope at the onset of convection, as well as the range of abundances detected in nova ejecta, we examine the effects of varying the composition of the accreted material. For high accretion rates and carbon mass fractions 0.002. These different triggering mechanisms, which occur for critical abundances relevant to many nova systems, alter the amount of mass that is accreted prior to a nova, causing the nova rate to depend on accreted composition. Upcoming deep optical surveys such as Pan-STARRS-1, Pan-STARRS-4, and the Large Synoptic Survey Telescope may allow us to detect the dependence of nova rates on accreted composition. Furthermore, the burning and depletion of 3He with a mas...

  14. Ultrasensitive detection of microRNA through rolling circle amplification on a DNA tetrahedron decorated electrode.

    Science.gov (United States)

    Miao, Peng; Wang, Bidou; Meng, Fanyu; Yin, Jian; Tang, Yuguo

    2015-03-18

    MicroRNAs are a class of evolutionally conserved, small noncoding RNAs involved in the regulation of gene expression and affect a variety of biological processes including cellular differentiation, immunological response, tumor development, and so on. Recently, microRNAs have been identified as promising disease biomarkers. In this work, we have fabricated a novel electrochemical method for ultrasensitive detection of microRNA. Generally, a DNA tetrahedron decorated gold electrode is employed as the recognition interface. Then, hybridizations between DNA tetrahedron, microRNA, and primer probe initiate rolling circle amplification (RCA) on the electrode surface. Silver nanoparticles attached to the RCA products provide significant electrochemical signals and a limit of detection as low as 50 aM is achieved. Moreover, homology microRNA family members with only one or two mismatches can be successfully distinguished. Therefore, this proposed method reveals great advancements toward improved disease diagnosis and prognosis.

  15. Atmospheric deposition 2000. NOVA 2003; Atmosfaerisk deposition 2000. NOVA 2003

    Energy Technology Data Exchange (ETDEWEB)

    Ellermann, T.; Hertel, O.; Hovmand, M.F.; Kemp, K.; Skjoeth, C.A.

    2001-11-01

    This report presents measurements and calculations from the atmospheric part of NOVA 2003 and covers results for 2000. It summarises the main results concerning concentrations and depositions of nitrogen, phosphorus and sulphur compounds related to eutrophication and acidification. Depositions of atmospheric compounds to Danish marine waters as well as land surface are presented. Measurements: In 2000 the monitoring program consisted of eight stations where wet deposition of ammonium, nitrate, phosphate (semi quantitatively) and sulphate were measured using bulk precipitation samplers. Six of the stations had in addition measurements of atmospheric content of A, nitrogen, phosphorus, and sulphur compounds in gas and particulate phase carried out by use of filter pack samplers. Filters were analysed at the National Environmental Research Institute. Furthermore nitrogen dioxide were measured using nitrogen dioxide filter samplers and monitors. Model calculations: The measurements in the monitoring program were supplemented with model calculations of concentrations and depositions of nitrogen and sulphur compounds to Danish land surface, marine waters, fjords and bays using the ACDEP model (Atmospheric Chemistry and Deposition). The model is a so-called trajectory model and simulates the physical and chemical processes in the atmosphere using meteorological and emission data as input. The advantage of combining measurements with model calculations is that the strengths of both methods is obtained. Conclusions concerning: 1) actual concentration levels at the monitoring stations, 2) deposition at the monitoring stations, 3) seasonal variations and 4) long term trends in concentrations and depositions are mainly based on the direct measurements. These are furthermore used to validate the results of the model calculations. Calculations and conclusions concerning: 1) depositions to land surface and to the individual marine water, 2) contributions from different emission

  16. Novas tecnologias, novas competências New Tecnologies, new skills

    Directory of Open Access Journals (Sweden)

    Geneviève Jacquinot Delaunay

    2008-01-01

    Full Text Available O texto aborda a relação dos jovens e adolescentes com tecnologias, nem "novas" nem "velhas", e sim instrumentos para informar e comunicar, divertir, auxiliar nos trabalhos escolares. Apesar de reconhecer a familiaridade dessa geração com o que há de mais avançado em termos de tecnologia, aponta a necessidade de se compreender a complexidade desse novo cenário de aprendizagem, que envolve o aprofundamento de conceitos como interatividade e interação, linguagem numérica, multimídia, internet e hipertexto. Na seqüência, faz uma análise do contato dos jovens com essa diversidade de meios, suas implicações no processo cognitivo e suas conseqüências comunicacionais. Finalmente, reconhece que a aprendizagem é hipercomplexa e que - apesar de todo avanço científico - a máquina, mesmo interativa, não pode proporcionar ao indivíduo o aprendizado que lhe proporciona a interação com outras pessoas.The paper discusses how young people relate to technology, not seen as new or old, but as an instrument to communicate and keep informed, amuse and to help in school projects. Although it is clear that the new generations are much more familiarized with new technology, the focus is on the need to understand the complexity of the new scenario, which requires a deeper understanding of the concepts of interactivity, multimedia, internet and hypertext. It is discussed how young people enter in contact with this diversity of instruments. It is stressed, however, that no matter how complex the computer can be, nothing can replace the role of interacting with other people in the learning process.

  17. Identification of plant microRNA homologs.

    Science.gov (United States)

    Dezulian, Tobias; Remmert, Michael; Palatnik, Javier F; Weigel, Detlef; Huson, Daniel H

    2006-02-01

    MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that regulate gene and protein expression in plants and animals. MiRNAs have so far been identified mostly by specific cloning of small RNA molecules, complemented by computational methods. We present a computational identification approach that is able to identify candidate miRNA homologs in any set of sequences, given a query miRNA. The approach is based on a sequence similarity search step followed by a set of structural filters.

  18. MicroRNA Expression Signatures During Malignant Progression From Barrett's Esophagus.

    Science.gov (United States)

    Bansal, Ajay; Gupta, Vijayalaxmi; Wang, Kenneth

    2016-06-01

    The rapid increase and poor survival of esophageal adenocarcinoma (EAC) have led to significant efforts to promote early detection. Given that the premalignant lesion of Barrett's esophagus (BE) is the major known risk factor for EAC, multiple investigators have studied biomarker signatures that can predict malignant progression of BE to EAC. MicroRNAs, a novel class of gene regulators, are small non-coding RNAs and have been associated with carcinogenesis. MicroRNAs are ideal biomarkers because of their remarkable stability in fixed tissues, a common method for collection of clinical specimens, and in blood either within exosomes or as microRNA-protein complexes. Multiple studies show potential of microRNAs as tissue and blood biomarkers for diagnosis and prognosis of EAC but the results need confirmation in prospective studies. Although head-to-head comparisons are lacking, microRNA panels require less genes than messenger RNA panels for diagnosis of EAC in BE. MicroRNA diagnostic panels will need to be compared for accuracy against global measures of genome instability that were recently shown to be good predictors of progression but require sophisticated analytic techniques. Early studies on blood microRNA panels are promising but have found microRNA markers to be inconsistent among studies. MicroRNA expression in blood is different between various microRNA sub-compartments such as exosomes and microRNA-protein complexes and could affect blood microRNA measurements. Further standardization is needed to yield consistent results. We have summarized the current understanding of the tissue and blood microRNA signatures that may predict the development and progression of EAC.

  19. microRNA Therapeutics in Cancer - An Emerging Concept.

    Science.gov (United States)

    Shah, Maitri Y; Ferrajoli, Alessandra; Sood, Anil K; Lopez-Berestein, Gabriel; Calin, George A

    2016-10-01

    MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic.

  20. microRNA Therapeutics in Cancer — An Emerging Concept

    Directory of Open Access Journals (Sweden)

    Maitri Y. Shah

    2016-10-01

    Full Text Available MicroRNAs (miRNAs are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported in several cancers, with several microRNAs playing oncogenic and tumor suppressive roles. Based on these, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we have focused on the roles of miRNAs in tumorigenesis, the miRNA-based therapeutic strategies currently being evaluated for use in cancer, and the advantages and current challenges to their use in the clinic.

  1. MicroRNAs and Cardiovascular Disease in Diabetes Mellitus

    Science.gov (United States)

    Ding, Yue

    2017-01-01

    Cardiovascular disease (CVD) is the major macrovascular complication of diabetes mellitus. Recently, although CVD morbidity and mortality have decreased as a result of comprehensive control of CVD risk factors, CVD remains the leading cause of death of patients with diabetes in many countries, indicating the potential underlying pathophysiological mechanisms. MicroRNAs are a class of noncoding, single-stranded RNA molecules that are involved in β-cell function, insulin secretion, insulin resistance, skeletal muscle, and adipose tissue and which play an important role in glucose homeostasis and the pathogenesis of diabetic complications. Here, we review recent progress in research on microRNAs in endothelial cell and vascular smooth muscle cell dysfunction, macrophage and platelet activation, lipid metabolism abnormality, and cardiomyocyte repolarization in diabetes mellitus. We also review the progress of microRNAs as potential biomarkers and therapeutic targets of CVD in patients with diabetes.

  2. Uma nova forma de Coffea

    Directory of Open Access Journals (Sweden)

    C. A. Krug

    1950-01-01

    Full Text Available Nos extensos trabalhos de melhoramento do cafeeiro, há 18 anos em realização na Subdivisão de Genética do Instituto Agronômico, tem-se dedicado especial atenção à espécie C. arabica L., pelo fato de todos os nossos cafèzais pertencerem a esta espécie que, sem dúvida, fornece o produto de melhor qualidade. Nas regiões de terras extremamente cansadas, um dos principais fatôres levados em consideração no melhoramento é a rusticidade, caráter êsse, entretanto, encontrado de preferência em outras espécies, tais como o C. canephora e C. Dewevrei, cujos cafés são de má qualidade. A hibridação interespecífica, que poderia reunir em uma só planta caraterísticos de rusticidade e boa qualidade de bebida, tem o inconveniente de dar origem a plantas triplóides, que são estéreis. Daí se deduz que a obtenção artificial de formas que combinassem êsses caraterísticos constitui problema, cuja solução é extremamente demorada. No presente trabalho, apresentam-se os caracteres de uma nova forma de Coffea, encontrada em cafèzal da Fazenda Itaporã, em Terra Roxa, município de Viradouro, que, com algumas ressalvas, oferece a desejada combinação de caracteres. Trata-se, provàvelmente, de um híbrido espontâneo entre C. arabica e C. Dewevrei, com 2n = 44 cromosômios, extremamente rústico e produtivo, cujas sementes fornecem uma bebida que pode ser classificada como boa. Apenas apresenta, como principal defeito, uma auto-esterilidade quase completa. Os seus caraterísticos botânicos são descritos em detalhe. Devido ao seu porte elevado, ramos abundantes e folhas grandes e coriáceas, esse cafeeiro se assemelha ao C. Dewevrei. Os frutos são oval-elípticos, de um vermelho bem escuro quando maduros, e as sementes oblongas, constatan-do-se elevada percentagem do tipo "moca" e "chocha". Quanto à constituição citológica, as pesquisas conduziram à hipótese de este cafeeiro possuir 22 cromosômios de C. arabica e 22 (n

  3. Hypoxia-regulated microRNAs in human cancer

    Institute of Scientific and Technical Information of China (English)

    Guomin SHEN; Xiaobo LI; Yong-feng JIA; Gary A PIAZZA; Yaguang XI

    2013-01-01

    Hypoxia plays an important role in the tumor microenvironment by allowing the development and maintenance of cancer cells,but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood.MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes.Studies have shown that hypoxia inducible factor 1 (HIF1) regulates a panel of microRNAs,whereas some of microRNAs target HIF1.The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis,such as angiogenesis,metabolism,apoptosis,cell cycle regulation,proliferation,metastasis,and resistance to anticancer therapy.This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells,It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvironments and thus benefit the development of new anticancer drugs.

  4. When does an old nova become a dwarf nova? Kinematics and age of the nova shell of the dwarf nova AT Cancri

    Science.gov (United States)

    Shara, Michael M.; Drissen, Laurent; Martin, Thomas; Alarie, Alexandre; Stephenson, F. Richard

    2017-02-01

    The Z Cam-type dwarf nova AT Cancri (AT Cnc) displays a classical nova (CN) shell, demonstrating that mass transfer in cataclysmic binaries decreases substantially after a CN eruption. The hibernation scenario of cataclysmic binaries predicts such a decrease, on a time-scale of a few centuries. In order to measure the time since AT Cnc's last CN eruption, we have measured the radial velocities of a hundred clumps in its ejecta with SITELLE, Canada-France-Hawaii Telescope's recently commissioned imaging Fourier transform spectrometer. These range from -455 to +490 km s-1. Coupled with the known distance to AT Cnc of 460 pc, the size of AT Cnc's shell, and a simple model of nova ejecta deceleration, we determine that the last CN eruption of this system occurred 330_{-90}^{+135} yr ago. This is the most rapid transition from a high mass-transfer rate, nova-like variable to a low mass-transfer rate, dwarf nova yet measured, and in accord with the hibernation scenario of cataclysmic binaries. We conclude by noting the similarity in the deduced outburst date (within a century of 1686 CE) of AT Cnc to a `guest star' reported in the constellation Cancer by Korean observers in 1645 CE.

  5. Gamma-ray emission from nova outbursts

    CERN Document Server

    Hernanz, M

    2013-01-01

    Classical novae produce radioactive nuclei which are emitters of gamma-rays in the MeV range. Some examples are the lines at 478 and 1275 keV (from 7Be and 22Na) and the positron-electron annihilation emission, with the 511 keV line and a continuum. Gamma-ray spectra and light curves are potential unique tools to trace the corresponding isotopes and to give insights on the properties of the expanding envelope. Another possible origin of gamma-rays is the acceleration of particles up to very high energies, so that either neutral pions or inverse Compton processes produce gamma-rays of energies larger than 100 MeV. MeV photons during nova explosions have not been detected yet, although several attempts have been made in the last decades; on the other hand, GeV photons from novae have been detected with the Fermi satellite in V407 Cyg, a nova in a symbiotic binary, where the companion is a red giant with a wind, instead of a main sequence star as in the cataclysmic variables hosting classical novae. Two more nov...

  6. Gamma-ray Novae: Rare or Nearby?

    CERN Document Server

    Morris, Paul J; Brown, Anthony M; Chadwick, Paula M

    2016-01-01

    Classical Novae were revealed as a surprise source of gamma-rays in Fermi LAT observations. During the first 8 years since the LAT was launched, 6 novae in total have been detected to > 5 sigma in gamma-rays, in contrast to the 69 discovered optically in the same period. We attempt to resolve this discrepancy by assuming all novae are gamma-ray emitters, and assigning peak one-day fluxes based on a flat distribution of the known emitters to a simulated population. To determine optical parameters, the spatial distribution and magnitudes of bulge and disc novae in M31 are scaled to the Milky Way, which we approximate as a disc with a 20 kpc radius and elliptical bulge with semi major axis 3 kpc and axis ratios 2:1 in the xy plane. We approximate Galactic reddening using a double exponential disc with vertical and radial scale heights of r_d = 5 kpc and z_d = 0.2 kpc, and demonstrate that even such a rudimentary model can easily reproduce the observed fraction of gamma-ray novae, implying that these apparently r...

  7. MicroRNA pharmacogenomics

    DEFF Research Database (Denmark)

    Rukov, Jakob Lewin; Shomron, Noam

    2011-01-01

    polymorphisms, copy number variations or differences in gene expression levels of drug metabolizing or transporting genes and drug targets. In this review paper, we focus instead on microRNAs (miRNAs): small noncoding RNAs, prevalent in metazoans, that negatively regulate gene expression in many cellular...... processes. We discuss how miRNAs, by regulating the expression of pharmacogenomic-related genes, can play a pivotal role in drug efficacy and toxicity and have potential clinical implications for personalized medicine....

  8. Role of microRNAs in the immune system, inflammation and cancer.

    Science.gov (United States)

    Raisch, Jennifer; Darfeuille-Michaud, Arlette; Nguyen, Hang Thi Thu

    2013-05-28

    MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentiation, development and apoptosis. In addition, microRNAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis.

  9. The Expanding Fireball of Nova Delphini 2013

    CERN Document Server

    Schaefer, G H; Gies, D R; Farrington, C D; Kloppenborg, B; Chesneau, O; Monnier, J D; Ridgway, S T; Scott, N; Tallon-Bosc, I; McAlister, H A; Boyajian, T; Maestro, V; Mourard, D; Meilland, A; Nardetto, N; Stee, P; Sturmann, J; Vargas, N; Baron, F; Ireland, M; Baines, E K; Che, X; Jones, J; Richardson, N D; Roettenbacher, R M; Sturmann, L; Turner, N H; Tuthill, P; van Belle, G; von Braun, K; Zavala, R T; Banerjee, D P K; Ashok, N M; Joshi, V; Becker, J; Muirhead, P S

    2015-01-01

    A classical nova occurs when material accreting onto the surface of a white dwarf in a close binary system ignites in a thermonuclear runaway. Complex structures observed in the ejecta at late stages could result from interactions with the companion during the common envelope phase. Alternatively, the explosion could be intrinsically bipolar, resulting from a localized ignition on the surface of the white dwarf or as a consequence of rotational distortion. Studying the structure of novae during the earliest phases is challenging because of the high spatial resolution needed to measure their small sizes. Here we report near-infrared interferometric measurements of the angular size of Nova Delphini 2013, starting from one day after the explosion and continuing with extensive time coverage during the first 43 days. Changes in the apparent expansion rate can be explained by an explosion model consisting of an optically thick core surrounded by a diffuse envelope. The optical depth of the ejected material changes ...

  10. NOVA laser facility for inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, W.W.

    1983-11-30

    The NOVA laser consists of ten beams, capable of concentrating 100 to 150 kJ of energy (in 3 ns) and 100 to 150 TW of power (in 100 ps) on experimental targets by 1985. NOVA will also be capable of frequency converting the fundamental laser wavelength (1.05 ..mu..m) to its second (0.525 ..mu..m) or third (0.35 ..mu..m) harmonic. This additional capability (80 to 120 kJ at 0.525 ..mu..m, 40 to 70 kJ at 0.35 ..mu..m) was approved by the US Department of Energy (DOE) in April 1982. These shorter wavelengths are much more favorable for ICF target physics. Current construction status of the NOVA facility, intended for completion in the autumn of 1984, will be presented.

  11. Enquête de satisfaction Novae

    CERN Multimedia

    2014-01-01

    Novae lance une enquête de satisfaction auprès de ses clients. Vous pouvez accéder au questionnaire au sujet des trois restaurants d’entreprise du CERN en utilisant le lien et les codes ci-dessous. Le délai de réponse est fixé au jeudi 29 mai.   https://survey.mis-trend.ch/NOVAE Voici les codes à introduire (en respectant la casse) pour entrer dans le questionnaire, selon le site : CERN Restaurant n°1 : CERN114 CERN Restaurant n°2 : CERN214 CERN Restaurant n°3 : CERN314   Nous attirons votre attention sur le fait que tout questionnaire rempli sera validé. Nous vous prions donc de ne pas utiliser ce lien pour tester le questionnaire. Merci d’avance pour votre collaboration. L'équipe Novae

  12. Um novo paradigma para uma nova antropologia

    Directory of Open Access Journals (Sweden)

    Susin, Luiz Carlos

    2007-01-01

    Full Text Available Este artigo recolhe relativas à identidade humana no contexto das pesquisas científicas e das transformações ocorridas nos últimos tempos, especialmente no século XX. A nova fisica, com um novo desenho do universo, uma nova cosmologia, radicaliza, por um lado, as questões em torno do humano, e, por outro lado, abre novas possibilidades. Um novo paradigma, mais holístico, incluindo a dimensão ecológica, ou ao menos com cenários mais adequados, pode ser vislumbrado, embora ainda não descrito, por estarmos numa "era de transição". Na parte que nos toca no universo - a terra - o futuro da vida depende, em grande parte, de decisões éticas que somente o ser humano é convocado a assumir

  13. Nova variedade de Menta arvensis

    Directory of Open Access Journals (Sweden)

    Abelardo Rodrigues Lima

    1952-09-01

    Full Text Available No quarto ano dos trabalhos de seleção com a menta japonêsa, foi encontrado um "seedling", o M. A. 701, que se destacou pela resistência à ferrugem e pela sua rusticidade. Os caracteres botânicos dessa variedade comercial, principalmente hábito vegetativo, coloração das fôlhas e das hastes, a tornam completa' mente distinta da variedade original. Esta distinção se confirma e acentua quando se compara a natureza dos componentes do óleo essencial da menta "Campinas" M. A. 701, descrita no presente trabalho, com a menta japonêsa comum. A maior produtividade da nova variedade comparada com a da menta japonesa comum foi desde logo também constatada pelos primeiros lavradores, a quem foram enviadas pequenas quantidades de rizomas, para plantio experimental. Foram cultivados em 1949-50 cêrca de 12 hectares; cm 1950-51, cêrca de 900 ha, e o prognóstico é que essa variedade tende a substituir totalmente a menta japonêsa anteriormente cultivada em São Paulo, devido ao seu maior valor econômico.A seedling, designated M.A.701, remarkable for its vigor and resistance to rust, was discovered during the fourth year of selection of Japanese mint (Mentha arvensis L. subsp. haplocalix Briquet var. piperascens Holmes or forma piperascens Malinvaud. The botanical characters of the variety derived from this seedling, especially the vegetative habit and colouring of leaves and stems, make it quite different from the original variety. This difference is enhanced, when we compare the nature of the essential oil components of "Campinas" M.A.701, as described in the present paper, with that of the common Japanese mint. The higher yield of the new variety, compared with that of the common Japanese mint, was soon confirmed by the first cultivators, to whom small quantities of rhizomes were sent for experimental planting. About 12 hectars were cultivated em 1949/50 and about 900 hectars in 1950/51. It is expected that the new variety will, on account

  14. Novas cartas portuguesas: uma abordagem feminista

    OpenAIRE

    Jesus, Isabel Henriques de

    2012-01-01

    Publicado em 1972 e imediatamente confiscado pela censura, Novas cartas portuguesas apresentam uma simultaneidade temporal com o surgimento de movimentos feministas alicerçados, em grande medida, nas questões do corpo e da escrita das mulheres. Exploram-se alguns aspectos do livro à luz dos feminismos de segunda vaga que enformaram os anos 60 e 70 do séc. XX, embora realçando o carácter actual e perforrnativo da escrita de Novas Cartas Portuguesas na construção de outros modelos não dicotómic...

  15. Nova in Centaurus - ASASSN-17gk

    Science.gov (United States)

    Waagen, Elizabeth O.

    2017-05-01

    AAVSO Alert Notice 578 announces the discovery of a galactic nova in Centaurus - ASASSN-17gk - by the ASAS-SN team at magnitude 10.9 V on 2017 May 17.28 UT. Spectroscopy indicating that ASASSN-17gk is a galactic nova was obtained by P. Luckas (International Centre for Radio Astronomy Research, Univ. Western Australia) on 2017 May 18.0598 UT (ATel #10399). Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.

  16. The peculiar nova V1309 Sco/Nova Sco 2008: A candidate twin of V838 Mon

    CERN Document Server

    Mason, Elena; Williams, Robert E; Preston, George; Bensby, Thomas

    2010-01-01

    Nova Scorpii 2008 was the target of our Directory Discretionary Time proposal at VLT+UVES in order to study the evolution, origin and abundances of the heavy-element absorption system recently discovered in 80% of classical novae in outburst. The early decline of Nova Scorpii 2008 was monitored with high resolution echelle spectroscopy at 5 different epochs. The analysis of the absorption and the emission lines show many unusual characteristics. Nova Scorpii 2008 is confirmed to differ from a common Classical Nova as well as a Symbiotic Recurrent Nova, and it shows characteristics which are common to the so called, yet debated, red-novae. The origin of this new nova remains uncertain.

  17. [MicroRNAs in neurobiology].

    Science.gov (United States)

    Kawahara, Yukio

    2008-12-01

    MicroRNAs have emerged as a new regulatory factor of gene expression. They mediate translational repression or degradation of their target mRNAs by RNA interference (RNAi). The expression of each microRNA is tightly regulated in a development- and cell-specific manner by various mechanisms such as blockade of let-7 family expression by Lin-28 or RNA editing. They also act as regulatory switches for development, organogenesis, and cellular differentiation or for controlling distinct functions that are required for the maintenance of each tissue and cell subtypes. The abundant expression of microRNAs as well as the exclusive expression of certain microRNAs in the central nervous system highlights their biological importance at all stages of neural development and in postmitotic and differentiated neurons. Further, some microRNAs, such as miRNA-134, and miRNA-132 are localized and are synthesized in part at synaptic sites in dendrites to regulate synaptic formation and plasticity. In addition to the imparting of basic knowledge about the biogenesis and mechanism of action of microRNAs, this review focuses on the recent advances in microRNA studies in neurobiology, including the expression pattern of microRNAs in the mammalian brain, the role of microRNAs in neural differentiation and maturation, formation and plasticity of synaptic connections, and maintenance of neural function such as the synthesis of the neurotransmitters in selected neurons. Finally, the possible connection between microRNA dysfunction and neurological diseases, and future implications for diagnosis, and treatment of defects in human brain development and neurodegenerative diseases are discussed.

  18. Targeting of microRNAs for therapeutics

    DEFF Research Database (Denmark)

    Stenvang, Jan; Lindow, Morten; Kauppinen, Sakari

    2008-01-01

    miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer...... and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent...... reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics....

  19. MicroRNAs in Human Pituitary Adenomas

    Directory of Open Access Journals (Sweden)

    Xu-Hui Li

    2014-01-01

    Full Text Available MicroRNAs (miRNAs are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10–15% of diagnosed brain tumors. Deregulated miRNAs and their targets contribute to pituitary adenomas progression and are associated with cell cycle control, apoptosis, invasion, and pharmacological treatment of pituitary adenomas. To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.

  20. Global expression profiling of rice microRNAs by one-tube stem-loop reverse transcription quantitative PCR revealed important roles of microRNAs in abiotic stress responses.

    Science.gov (United States)

    Shen, Jianqiang; Xie, Kabin; Xiong, Lizhong

    2010-12-01

    MicroRNAs are a class of endogenous small RNA molecules (20-24 nucleotides) that have pivotal roles in regulating gene expression mostly at posttranscriptional levels in plants. Plant microRNAs have been implicated in the regulation of diverse biological processes including growth and stress responses. However, the information about microRNAs in regulating abiotic stress responses in rice is limited. We optimized a one-tube stem-loop reverse transcription quantitative PCR (ST-RT qPCR) for high-throughput expression profiling analysis of microRNAs in rice under normal and stress conditions. The optimized ST-RT qPCR method was as accurate as small RNA gel blotting and was more convenient and time-saving than other methods in quantifying microRNAs. With this method, 41 rice microRNAs were quantified for their relative expression levels after drought, salt, cold, and abscisic acid (ABA) treatments. Thirty-two microRNAs showed induced or suppressed expression after stress or ABA treatment. Further analysis suggested that stress-responsive cis-elements were enriched in the promoters of stress-responsive microRNA genes. The expressions of five and seven microRNAs were significantly affected in the rice plant with defects in stress tolerance regulatory genes OsSKIPa and OsbZIP23, respectively. Some of the predicted target genes of these microRNAs were also related to abiotic stresses. We conclude that ST-RT qPCR is an efficient and reliable method for expression profiling of microRNAs and a significant portion of rice microRNAs participate in abiotic stress response and regulation.

  1. Pre-nova X-ray observations of V2491 Cyg (Nova Cyg 2008b)

    CERN Document Server

    Ibarra, A; Osborne, J P; Page, K; Ness, J U; Saxton, R D; Baumgartner, W; Beckmann, V; Bode, M F; Hernanz, M; Mukai, K; Orio, M; Sala, G; Starrfield, S; Wynn, G A

    2009-01-01

    Classical novae are phenomena caused by explosive hydrogen burning on an accreting white dwarf. So far, only one classical nova has been identified in X-rays before the actual optical outburst occurred (V2487 Oph). The recently discovered nova, V2491 Cyg, is one of the fastest (He/N) novae observed so far. Using archival ROSAT, XMM-Newton and Swift data, we show that V2491 Cyg was a persistent X-ray source during its quiescent time before the optical outburst. We present the X-ray spectral characteristics and derive X-ray fluxes. The pre-outburst X-ray emission is variable, and at least in one observation it shows a very soft X-ray source.

  2. Hydrodynamic models for novae with ejecta rich in oxygen, neon and magnesium

    Science.gov (United States)

    Starrfield, S.; Sparks, W. M.; Truran, J. W.

    1985-01-01

    The characteristics of a new class of novae are identified and explained. This class consists of those objects that have been observed to eject material rich in oxygen, neon, magnesium, and aluminum at high velocities. We propose that for this class of novae the outburst is occurring not on a carbon-oxygen white dwarf but on an oxygen-neon-magnesium white dwarf which has evolved from a star which had a main sequence mass of approx. 8 solar masses to approx. 12 solar masses. An outburst was simulated by evolving 1.25 solar mass white dwarfs accreting hydrogen rich material at various rates. The effective enrichment of the envelope by ONeMg material from the core is simulated by enhancing oxygen in the accreted layers. The resulting evolutionary sequences can eject the entire accreted envelope plus core material at high velocities. They can also become super-Eddington at maximum bolometric luminosity. The expected frequency of such events (approx. 1/4) is in good agreement with the observed numbers of these novae.

  3. NOVA Making Stuff Season 2

    Energy Technology Data Exchange (ETDEWEB)

    Leombruni, Lisa; Paulsen, Christine Andrews

    2014-12-12

    Over the course of four weeks in fall 2013, 11.7 million Americans tuned in to PBS to follow host David Pogue as he led them in search of engineering and scientific breakthroughs poised to change our world. Levitating trains, quantum computers, robotic bees, and bomb-detecting plants—these were just a few of the cutting-edge innovations brought into the living rooms of families across the country in NOVA’s four-part series, Making Stuff: Faster, Wilder, Colder, and Safer. Each of the four one-hour programs gave viewers a behind-the-scenes look at novel technologies poised to change our world—showing them how basic research and scientific discovery can hold the keys to transforming how we live. Making Stuff Season 2 (MS2) combined true entertainment with educational value, creating a popular and engaging series that brought accessible science into the homes of millions. NOVA’s goal to engage the public with such technological innovation and basic research extended beyond the broadcast series, including a variety of online, educational, and promotional activities: original online science reporting, web-only short-form videos, a new online quiz-game, social media engagement and promotion, an educational outreach “toolkit” for science educators to create their own “makerspaces,” an online community of practice, a series of nationwide Innovation Cafés, educator professional development, a suite of teacher resources, an “Idealab,” participation in national conferences, and specialized station relation and marketing. A summative evaluation of the MS2 project indicates that overall, these activities helped make a significant impact on the viewers, users, and participants that NOVA reached. The final evaluation conducted by Concord Evaluation Group (CEG) confidently concluded that the broadcast, website, and outreach activities were successful at achieving the project’s intended impacts. CEG reported that the MS2 series and website content were

  4. NOVA making stuff: Season 2

    Energy Technology Data Exchange (ETDEWEB)

    Leombruni, Lisa [WGBH Educational Foundation, Boston, MA (United States); Paulsen, Christine Andrews [Concord Evaluation Group, Concord, MA (United States)

    2014-12-12

    Over the course of four weeks in fall 2013, 11.7 million Americans tuned in to PBS to follow host David Pogue as he led them in search of engineering and scientific breakthroughs poised to change our world. Levitating trains, quantum computers, robotic bees, and bomb-detecting plants—these were just a few of the cutting-edge innovations brought into the living rooms of families across the country in NOVA’s four-part series, Making Stuff: Faster, Wilder, Colder, and Safer. Each of the four one-hour programs gave viewers a behind-the-scenes look at novel technologies poised to change our world—showing them how basic research and scientific discovery can hold the keys to transforming how we live. Making Stuff Season 2 (MS2) combined true entertainment with educational value, creating a popular and engaging series that brought accessible science into the homes of millions. NOVA’s goal to engage the public with such technological innovation and basic research extended beyond the broadcast series, including a variety of online, educational, and promotional activities: original online science reporting, web-only short-form videos, a new online quiz-game, social media engagement and promotion, an educational outreach “toolkit” for science educators to create their own “makerspaces,” an online community of practice, a series of nationwide Innovation Cafés, educator professional development, a suite of teacher resources, an “Idealab,” participation in national conferences, and specialized station relation and marketing. A summative evaluation of the MS2 project indicates that overall, these activities helped make a significant impact on the viewers, users, and participants that NOVA reached. The final evaluation conducted by Concord Evaluation Group (CEG) confidently concluded that the broadcast, website, and outreach activities were successful at achieving the project’s intended impacts. CEG reported that the MS2 series and website content were

  5. ULF fluctuations at Terra Nova Bay (Antarctica

    Directory of Open Access Journals (Sweden)

    A. Meloni

    2000-06-01

    Full Text Available ULF geomagnetic field measurements in Antarctica are a very important tool for better understanding the dynamics of the Earth’s magnetosphere and its response to the variable solar wind conditions. We review the results obtained in the last few years at the Italian observatory at Terra Nova Bay

  6. When does an old nova become a dwarf nova? Kinematics and age of the nova shell of the dwarf nova AT Cnc

    CERN Document Server

    Shara, Michael M; Martin, Thomas; Alarie, Alexandre

    2016-01-01

    The Z Cam-type dwarf nova AT Cnc displays a classical nova (CN) shell, demonstrating that mass transfer in cataclysmic binaries decreases substantially after a CN eruption. The hibernation scenario of cataclysmic binaries predicts such a decrease, on a timescale of a few centuries. In order to measure the time since AT Cnc's last CN eruption, we have measured the radial velocities of a hundred clumps in its ejecta with SITELLE, CFHT's recently commissioned imaging Fourier transform spectrometer. These range from -455 to +490 km/s. Coupled with the known distance to AT Cnc of 460 pc (Shara 2012), the size of AT Cnc's shell, and a simple model of nova ejecta deceleration, we determine that the last CN eruption of this system occurred $330_{-90}^{+135}$ years ago. This is the most rapid transition from a high mass transfer rate, novalike variable to a low mass transfer rate, dwarf nova yet measured, and in accord with the hibernation scenario of cataclysmic binaries. We conclude by noting the similarity in deduc...

  7. The expanding fireball of Nova Delphini 2013.

    Science.gov (United States)

    Schaefer, G H; ten Brummelaar, T; Gies, D R; Farrington, C D; Kloppenborg, B; Chesneau, O; Monnier, J D; Ridgway, S T; Scott, N; Tallon-Bosc, I; McAlister, H A; Boyajian, T; Maestro, V; Mourard, D; Meilland, A; Nardetto, N; Stee, P; Sturmann, J; Vargas, N; Baron, F; Ireland, M; Baines, E K; Che, X; Jones, J; Richardson, N D; Roettenbacher, R M; Sturmann, L; Turner, N H; Tuthill, P; van Belle, G; von Braun, K; Zavala, R T; Banerjee, D P K; Ashok, N M; Joshi, V; Becker, J; Muirhead, P S

    2014-11-13

    A classical nova occurs when material accreting onto the surface of a white dwarf in a close binary system ignites in a thermonuclear runaway. Complex structures observed in the ejecta at late stages could result from interactions with the companion during the common-envelope phase. Alternatively, the explosion could be intrinsically bipolar, resulting from a localized ignition on the surface of the white dwarf or as a consequence of rotational distortion. Studying the structure of novae during the earliest phases is challenging because of the high spatial resolution needed to measure their small sizes. Here we report near-infrared interferometric measurements of the angular size of Nova Delphini 2013, starting one day after the explosion and continuing with extensive time coverage during the first 43 days. Changes in the apparent expansion rate can be explained by an explosion model consisting of an optically thick core surrounded by a diffuse envelope. The optical depth of the ejected material changes as it expands. We detect an ellipticity in the light distribution, suggesting a prolate or bipolar structure that develops as early as the second day. Combining the angular expansion rate with radial velocity measurements, we derive a geometric distance to the nova of 4.54 ± 0.59 kiloparsecs from the Sun.

  8. Cinema Interativo: novas possibilidades de ambientes imersivos

    Directory of Open Access Journals (Sweden)

    Natália Aly Menezes

    2011-12-01

    Full Text Available O texto “Cinema Interativo: novas possibilidades de ambientes imersivos”, sintetiza a pesquisa  de-senvolvida pela autora, como projeto de Pós-Graduação no curso Tecnologia da Inteligência e Design Digital – PUC-SP. A pesquisa busca reunir uma análise atenciosa diante da entrada da tecnologia di-gital, tecnologia esta que interfere inevitavelmente na linguagem cinematográfica, e não apenas em sua estética. Com a abertura do mundo dos números binários (código das informações computacionais, e a possibilidade de digitalização da imagem, o que era matéria se desmaterializa e infinitas possibilidades criacionais surgem, inclusive, abrindo portas para experimentar o cinema de maneira expandida. No-vas formas de construção narrativa, nova relação espectador-cinema, um novo tempo e espaço, novas formas de significações; tudo pode sofrer alterações. O texto parte de estudos feitos com base em teóri-cos como Peter Weibel, Jeffrey Shaw, Lev Manovich, entre outros.

  9. BK Lyncis: The Oldest Old Nova?... And a Bellwether for Cataclysmic-Variable Evolution

    CERN Document Server

    Patterson, Joseph; Kemp, Jonathan; de Miguel, Enrique; Krajci, Thomas; Foote, Jerry; Hambsch, Franz-Josef; Campbell, Tut; Roberts, George; Cejudo, David; Dvorak, Shawn; Vanmunster, Tonny; Koff, Robert; Skillman, David; Harvey, David; Martin, Brian; Rock, John; Boyd, David; Oksanen, Arto; Morelle, Etienne; Ulowetz, Joseph; Kroes, Anthony; Sabo, Richard; Jensen, Lasse

    2012-01-01

    We summarize the results of a 20-year campaign to study the light curves of BK Lyncis, a nova-like star strangely located below the 2-3 hour orbital period gap in the family of cataclysmic variables. Two apparent "superhumps" dominate the nightly light curves - with periods 4.6% longer, and 3.0% shorter, than P_orb. The first appears to be associated with the star's brighter states (V~14), while the second appears to be present throughout and becomes very dominant in the low state (V~15.7). Starting in the year 2005, the star's light curve became indistinguishable from that of a dwarf nova - in particular, that of the ER UMa subclass. Reviewing all the star's oddities, we speculate: (a) BK Lyn is the remnant of the probable nova on 30 December 101, and (b) it has been fading ever since, but has taken ~2000 years for the accretion rate to drop sufficiently to permit dwarf-nova eruptions. If such behavior is common, it can explain other puzzles of CV evolution. One: why the ER UMa class even exists (because all...

  10. The Shape of Long Outbursts in U Gem Type Dwarf Novae from AAVSO Data

    Science.gov (United States)

    Cannizzo, John K.

    2012-01-01

    We search the American Association of Variable Star Observers (AAVSO) archives of the two best studied dwarf novae in an attempt to find light curves for long out bursts that are extremely well-characterized. The systems are U Gem and S8 Cyg. Our goal is to search for embedded precursors such as those that have been found recently in the high fidelity Kepler data for superoutbursts of some members of the 8U UMa subclass of dwarf novae. For the vast majority of AAV80 data, the combination of low data cadence and large errors associated with individual measurements precludes one from making any strong statement about the shape of the long outbursts. However, for a small number of outbursts, extensive long term monitoring with digital photometry yields high fidelity light curves. We report the finding of embedded precursors in two of three candidate long outbursts. This reinforces van Paradijs' finding that long outbursts in dwarf novae above the period gap and superoutbursts in systems below the period gap constitute a unified class. The thermal-tidal instability to account for superoutbursts in the SU UMa stars predicts embedded precursors only for short orbital period dwarf novae, therefore the presence of embedded precursors in long orbital period systems - U Gem and SS Cyg - argues for a more general mechanism to explain long outbursts.

  11. The NOvA software testing framework

    Science.gov (United States)

    Tamsett, M.; C Group

    2015-12-01

    The NOvA experiment at Fermilab is a long-baseline neutrino experiment designed to study vε appearance in a vμ beam. NOvA has already produced more than one million Monte Carlo and detector generated files amounting to more than 1 PB in size. This data is divided between a number of parallel streams such as far and near detector beam spills, cosmic ray backgrounds, a number of data-driven triggers and over 20 different Monte Carlo configurations. Each of these data streams must be processed through the appropriate steps of the rapidly evolving, multi-tiered, interdependent NOvA software framework. In total there are greater than 12 individual software tiers, each of which performs a different function and can be configured differently depending on the input stream. In order to regularly test and validate that all of these software stages are working correctly NOvA has designed a powerful, modular testing framework that enables detailed validation and benchmarking to be performed in a fast, efficient and accessible way with minimal expert knowledge. The core of this system is a novel series of python modules which wrap, monitor and handle the underlying C++ software framework and then report the results to a slick front-end web-based interface. This interface utilises modern, cross-platform, visualisation libraries to render the test results in a meaningful way. They are fast and flexible, allowing for the easy addition of new tests and datasets. In total upwards of 14 individual streams are regularly tested amounting to over 70 individual software processes, producing over 25 GB of output files. The rigour enforced through this flexible testing framework enables NOvA to rapidly verify configurations, results and software and thus ensure that data is available for physics analysis in a timely and robust manner.

  12. Terra Nova development : challenges and lessons learned

    Energy Technology Data Exchange (ETDEWEB)

    Lever, G. [Petro-Canada, Inc. (Canada)

    2001-07-01

    The major oil and gas fields in Canada's east coast were illustrated for this power point presentation which focused on the development concept of the Terra Nova. Terra Nova is the first floating production system (FPSO) development and only the second offshore oil development on the challenging Grand Banks of Newfoundland. It is also the first offshore facility in Canada to be certified to both offshore petroleum and shipping regulations. In addition, it represents the first fully-automated disconnectable turret, riser and mooring system on an FPSO, and the first to have glory holes for protecting subsea equipment from iceberg damage. The FPSO can withstand an impact with a 100,000 tonne iceberg. The Terra Nova project also represents the first attempt at trenching in stiff hard pan soil conditions which are typical of the Grand Banks. The physical environment design criteria for the Terra Nova in terms of water depth, air temperature, water temperature, icebergs, current, wind and waves were provided along with the functional requirements in terms of oil production, gas compression, total fluids, water injection, produced water, gas injection and water injection. An illustration of the FPSO topsides modules layout was also provided. The alliance-based contracting approach was adopted in 1995 and gave Petro-Canada access to the collective capability of major contractors that were able to face the technical challenges on Terra Nova. Some of the lessons learned from this contracting approach are that a strong central technical integration team should be implemented early and maintained through to project completion and that interfaces must be identified early and managed in a manner according to risk associated with the cost and schedule. tabs., figs.

  13. Mechanisms of control of microRNA biogenesis

    OpenAIRE

    Davis-Dusenbery, Brandi N.; Hata, Akiko

    2010-01-01

    MicroRNAs (miRNAs) are a class of ∼22 nt non-coding RNAs that control diverse biological functions in animals, plants and unicellular eukaryotes by promoting degradation or inhibition of translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated. Aberrant expression of miRNAs has been linked to developmental abnormalities and human diseases, including cancer and cardiovascular disorders. The recent identification of mechanisms of miRNA biogenesis regu...

  14. Overview of MicroRNA Biology

    OpenAIRE

    2015-01-01

    In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of mRNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA (siRNA). However, microRNA function is more complicated and nuanced than this ‘on-off’ model would suggest. Further, many microRNA targets are t...

  15. MicroRNA and cancer

    National Research Council Canada - National Science Library

    Jansson, Martin D; Lund, Anders H

    2012-01-01

    .... The best characterized non‐coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human...

  16. A unified model for the spectrophotometric development of classical and recurrent novae: the role of asphericity of the ejecta

    CERN Document Server

    Shore, Steven N

    2013-01-01

    There is increasing evidence that the geometry, and not only the filling factors, of nova ejecta is important in the interpretation of their spectral and photometric developments. Ensembles of spectra and light curves have provided general typographies. This Letter suggests how these can be unified.The observed spread in the maximum magnitude - rate of decline (MMRD) relation is argued to result from the range of opening angles and inclination of the ejecta, and not only to their masses and velocities. The spectroscopic classes can be similarly explained and linked to the behavior of the light curves. The secondary maximum observed in some dust forming novae is a natural consequence of the asphericity. Neither secondary ejections nor winds are needed to explain the phenomenology. The spectrophotometric development of classical novae can be understood within a single phenomenological model with bipolar, although not jet-like, mass ejecta. High resolution spectropolarimetry will be an essential analytical tool.

  17. The awakening of a classical nova from hibernation

    Science.gov (United States)

    Mróz, Przemek; Udalski, Andrzej; Pietrukowicz, Paweł; Szymański, Michał K.; Soszyński, Igor; Wyrzykowski, Łukasz; Poleski, Radosław; Kozłowski, Szymon; Skowron, Jan; Ulaczyk, Krzysztof; Skowron, Dorota; Pawlak, Michał

    2016-09-01

    Cataclysmic variable stars—novae, dwarf novae, and nova-likes—are close binary systems consisting of a white dwarf star (the primary) that is accreting matter from a low-mass companion star (the secondary). From time to time such systems undergo large-amplitude brightenings. The most spectacular eruptions, with a ten-thousandfold increase in brightness, occur in classical novae and are caused by a thermonuclear runaway on the surface of the white dwarf. Such eruptions are thought to recur on timescales of ten thousand to a million years. In between, the system’s properties depend primarily on the mass-transfer rate: if it is lower than a billionth of a solar mass per year, the accretion becomes unstable and the matter is dumped onto the white dwarf during quasi-periodic dwarf nova outbursts. The hibernation hypothesis predicts that nova eruptions strongly affect the mass-transfer rate in the binary, keeping it high for centuries after the event. Subsequently, the mass-transfer rate should significantly decrease for a thousand to a million years, starting the hibernation phase. After that the nova awakes again—with accretion returning to the pre-eruption level and leading to a new nova explosion. The hibernation model predicts cyclical evolution of cataclysmic variables through phases of high and low mass-transfer. The theory gained some support from the discovery of ancient nova shells around the dwarf novae Z Camelopardalis and AT Cancri, but direct evidence for considerable mass-transfer changes prior, during and after nova eruptions has not hitherto been found. Here we report long-term observations of the classical nova V1213 Cen (Nova Centauri 2009) covering its pre- and post-eruption phases and precisely documenting its evolution. Within the six years before the explosion, the system revealed dwarf nova outbursts indicative of a low mass-transfer rate. The post-nova is two orders of magnitude brighter than the pre-nova at minimum light with no trace of

  18. The awakening of a classical nova from hibernation.

    Science.gov (United States)

    Mróz, Przemek; Udalski, Andrzej; Pietrukowicz, Paweł; Szymański, Michał K; Soszyński, Igor; Wyrzykowski, Łukasz; Poleski, Radosław; Kozłowski, Szymon; Skowron, Jan; Ulaczyk, Krzysztof; Skowron, Dorota; Pawlak, Michał

    2016-09-29

    Cataclysmic variable stars-novae, dwarf novae, and nova-likes-are close binary systems consisting of a white dwarf star (the primary) that is accreting matter from a low-mass companion star (the secondary). From time to time such systems undergo large-amplitude brightenings. The most spectacular eruptions, with a ten-thousandfold increase in brightness, occur in classical novae and are caused by a thermonuclear runaway on the surface of the white dwarf. Such eruptions are thought to recur on timescales of ten thousand to a million years. In between, the system's properties depend primarily on the mass-transfer rate: if it is lower than a billionth of a solar mass per year, the accretion becomes unstable and the matter is dumped onto the white dwarf during quasi-periodic dwarf nova outbursts. The hibernation hypothesis predicts that nova eruptions strongly affect the mass-transfer rate in the binary, keeping it high for centuries after the event. Subsequently, the mass-transfer rate should significantly decrease for a thousand to a million years, starting the hibernation phase. After that the nova awakes again-with accretion returning to the pre-eruption level and leading to a new nova explosion. The hibernation model predicts cyclical evolution of cataclysmic variables through phases of high and low mass-transfer. The theory gained some support from the discovery of ancient nova shells around the dwarf novae Z Camelopardalis and AT Cancri, but direct evidence for considerable mass-transfer changes prior, during and after nova eruptions has not hitherto been found. Here we report long-term observations of the classical nova V1213 Cen (Nova Centauri 2009) covering its pre- and post-eruption phases and precisely documenting its evolution. Within the six years before the explosion, the system revealed dwarf nova outbursts indicative of a low mass-transfer rate. The post-nova is two orders of magnitude brighter than the pre-nova at minimum light with no trace of dwarf

  19. MicroRNA and Brain Tumors

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    MicroRNAs (miRNAs) were first described in 1993 by Lee and colleagues, and the term microRNA was only introduced in 2001 in a set of three articles in Science[1]. One of the biggest surprises in the past few years has been the emergence of miRNAs as a major new class of gene expression regulators. Recent studies suggest that miRNA alterations are involved in the initiation and progression of human cancer. The brain tumor,glioblastoma multiforme, is the most malignant and deadly form of gliomas.The prognosis is poor and the median survival with combined radiotherapy and chemotherapy is only 14.6 months. With the discovery of miRNA, the miRNA profiles may become useful biomarkers for brain tumor diagnostics,and miRNA therapy could be a powerful tool for brain tumor prevention and therapeutics. This review outlines the background of miRNA and its expression and therapeutic potential for brain tumors.

  20. microRNA expression profile of peripheral blood mononuclear cells of Klinefelter syndrome.

    Science.gov (United States)

    Sui, Weiguo; Ou, Minglin; Chen, Jiejing; Li, Huan; Lin, Hua; Zhang, Yue; Li, Wuxian; Xue, Wen; Tang, Donge; Gong, Weiwei; Zhang, Ruohan; Li, Fengyan; Dai, Yong

    2012-11-01

    microRNAs are a type of small non-coding RNAs which play important roles in post-transcriptional gene regulation, and the characterization of microRNA expression profiling in peripheral blood mononuclear cells (PBMCs) from patients with Klinefelter syndrome requires further investigation. In this study, PBMCs were obtained from patients with Klinefelter syndrome and normal controls. After preparation of small RNA libraries, the two groups of samples were sequenced simultaneously using next generation high-throughput sequencing technology, and novel and known microRNAs were analyzed. A total of 9,772,392 and 9,717,633 small RNA reads were obtained; 8,014,466 (82.01%) and 8,104,423 (83.40%) genome-matched reads, 64 and 49 novel microRNAs were identified in the library of Klinefelter syndrome and the library of healthy controls, respectively. There were 71 known microRNAs with differential expression levels between the two libraries. Clustering of over-represented gene ontology (GO) classes in predicted targets of novel microRNAs in the Klinefelter syndrome library showed that the most significant GO terms were genes involved in the endomembrane system, nucleotide binding and kinase activity. Our data revealed that there are a large number of microRNAs deregulated in PBMCs taken from patients with Klinefelter syndrome, of which certain novel and known microRNAs may be involved in the pathological process of Klinefelter syndrome. Further studies are necessary to determine the roles of microRNAs in the pathological process of Klinefelter syndrome in the future.

  1. Dwarf Nova Outbursts with Magnetorotational Turbulence

    CERN Document Server

    Coleman, M S B; Blaes, O; Lasota, J -P; Hirose, S

    2016-01-01

    The phenomenological Disc Instability Model has been successful in reproducing the observed light curves of dwarf nova outbursts by invoking an enhanced Shakura-Sunyaev $\\alpha$ parameter $\\sim0.1-0.2$ in outburst compared to a low value $\\sim0.01$ in quiescence. Recent thermodynamically consistent simulations of magnetorotational (MRI) turbulence with appropriate opacities and equation of state for dwarf nova accretion discs have found that thermal convection enhances $\\alpha$ in discs in outburst, but only near the hydrogen ionization transition. At higher temperatures, convection no longer exists and $\\alpha$ returns to the low value comparable to that in quiescence. In order to check whether this enhancement near the hydrogen ionization transition is sufficient to reproduce observed light curves, we incorporate this MRI-based variation in $\\alpha$ into the Disc Instability Model, as well as simulation-based models of turbulent dissipation and convective transport. These MRI-based models can successfully r...

  2. Tycho Brahe and the Nova of 1572

    Science.gov (United States)

    Gingerich, O.

    2005-12-01

    The brilliant Nova of 1572 marked the beginning of the end of Aristotelian cosmology and provided the defining moment when the young Tycho Brahe became a professional astronomer. He received more than a ton of gold from the Danish king to build his Uraniborg Observatory. His instruments, the finest produced in the pre-telescopic age, enabled him to establish that both the nova and the Comet of 1577 lay beyond the moon, contrary to Aristotle's teaching. His major attempt to establish the distance to Mars (in order to distinguish between the Ptolemaic and Copernican cosmologies) failed, but left in its wake a magnificently accurate set of data that enabled Kepler to make the greatest advance in celestial mechanics since Copernicus himself.

  3. Quark Nova Model for Fast Radio Bursts

    CERN Document Server

    Shand, Zachary; Koning, Nico; Ouyed, Rachid

    2015-01-01

    FRBs are puzzling, millisecond, energetic radio transients with no discernible source; observations show no counterparts in other frequency bands. The birth of a quark star from a parent neutron star experiencing a quark nova - previously thought undetectable when born in isolation - provides a natural explanation for the emission characteristics of FRBs. The generation of unstable r-process elements in the quark nova ejecta provides millisecond exponential injection of electrons into the surrounding strong magnetic field at the parent neutron star's light cylinder via $\\beta$-decay. This radio synchrotron emission has a total duration of hundreds of milliseconds and matches the observed spectrum while reducing the inferred dispersion measure by approximately 200 cm$^{-3}$ pc. The model allows indirect measurement of neutron star magnetic fields and periods in addition to providing astronomical measurements of $\\beta$-decay chains of unstable neutron rich nuclei. Using this model, we can calculate expected FR...

  4. Neutrino Oscillation Results from NOvA

    CERN Document Server

    CERN. Geneva

    2016-01-01

    NOvA is an accelerator long-baseline neutrino oscillation experiment optimised to measure electron neutrino appearance in a high-purity beam of muon neutrinos from Fermilab. The exciting discovery of the theta13 neutrino mixing angle in 2012 has opened a door to making multiple new measurements of neutrinos. These include leptonic CP violation, the neutrino mass ordering and the octant of theta23. NOvA with its 810km baseline and higher energy beam has about triple the matter effect of T2K which opens a new window on the neutrino mass ordering. With about 20% of our design beam exposure and significant analysis improvements we have recently released updated results. I will present both our disappearance and appearance measurements.

  5. Discovery of an eclipsing dwarf nova in the ancient nova shell Te 11

    CERN Document Server

    Miszalski, Brent; Littlefair, Stuart P; Warner, Brian; Boffin, Henri M J; Corradi, Romano L M; Jones, David; Motsoaledi, Mokhine; Rodríguez-Gil, Pablo; Sabin, Laurence; Santander-García, Miguel

    2015-01-01

    We report on the discovery of an eclipsing dwarf nova (DN) inside the peculiar, bilobed nebula Te 11. Modelling of high-speed photometry of the eclipse finds the accreting white dwarf to have a mass 1.18 M$_\\odot$ and temperature 13 kK. The donor spectral type of M2.5 results in a distance of 330 pc, colocated with Barnard's loop at the edge of the Orion-Eridanus superbubble. The perplexing morphology and observed bow shock of the slowly-expanding nebula may be explained by strong interactions with the dense interstellar medium in this region. We match the DN to the historic nova of 483 CE in Orion and postulate that the nebula is the remnant of this eruption. This connection supports the millennia time scale of the post-nova transition from high to low mass-transfer rates. Te 11 constitutes an important benchmark system for CV and nova studies as the only eclipsing binary out of just three DNe with nova shells.

  6. The SuperNova Early Warning System

    OpenAIRE

    Scholberg, K.

    2008-01-01

    A core collapse in the Milky Way will produce an enormous burst of neutrinos in detectors world-wide. Such a burst has the potential to provide an early warning of a supernova's appearance. I will describe the nature of the signal, the sensitivity of current detectors, and SNEWS, the SuperNova Early Warning System, a network designed to alert astronomers as soon as possible after the detected neutrino signal.

  7. Nova pulse power system description and status

    Energy Technology Data Exchange (ETDEWEB)

    Holloway, R.W.; Whitham, K.; Merritt, B.T.; Gritton, D.G.; Oicles, J.A.

    1981-06-01

    The Nova laser system is designed to produce critical data in the nation's inertial confinement fusion effort. It is the world's largest peak power laser and presents various unique pulse power problems. In this paper, pulse power systems for this laser are described, the evolutionary points from prior systems are pointed out, and the current status of the hardware is given.

  8. /sup 7/Li production in Nova explosions

    Energy Technology Data Exchange (ETDEWEB)

    Starrfield, S.; Truran, J.W.; Sparks, W.M.; Arnould, M.

    1978-06-01

    Calculations of /sup 7/Li production occurring as a concomitant of thermonuclear runaways in hydrogen envelopes of white dwarfs are reported. It is found that sufficient /sup 7/Li can be produced in models displaying fast--nova-like features to suggest that the corresponding objects represent significant contributors to the /sup 7/Li enrichment of galactic matter. The sensitivities of these results to various assumptions and uncertainties are discussed.

  9. Shocks in nova outflows. I. Thermal emission

    CERN Document Server

    Metzger, Brian D; Vurm, Indrek; Beloborodov, Andrei M; Chomiuk, Laura; Sokoloski, J L; Nelson, Thomas

    2014-01-01

    Evidence for shocks in nova outflows include (1) multiple velocity components in the optical spectra; (2) keV X-ray emission weeks to months after the outburst; (3) early radio flare on timescales of months, in excess of that predicted from the freely expanding photo-ionized gas; and (4) ~ GeV gamma-rays. We present a 1D model for the shock interaction between the fast nova outflow and a dense external shell (DES) and its associated thermal X-ray, optical, and radio emission. The forward shock is radiative initially when the density of shocked gas is highest, at which times radio emission originates from the dense cooling layer immediately downstream of the shock. The radio light curve is characterized by sharper rises to maximum and later peak times at progressively lower frequencies, with a peak brightness temperature that is approximately independent of frequency. We apply our model to the recent gamma-ray classical nova V1324 Sco, obtaining an adequate fit to the early radio maximum for reasonable assumpt...

  10. Introduction to the Nova technical contract

    Energy Technology Data Exchange (ETDEWEB)

    Lindl, J.D.; Kilkenny, J.D.

    1996-06-01

    The 1990 National Academy of Sciences (NAS) final report recommended proceeding with the construction of a 1-to 2-MJ Nd-doped glass laser designed to achieve ignition in the laboratory (a laser originally called the Nova Upgrade, but now called the National Ignition Facility, or NIF, and envisioned as a national user facility). As a prerequisite, the report recommended completion of a series of target physics objectives on the Nova laser in use at the Lawrence Livermore National Laboratory (LLNL). Meeting these objectives, which were called the Nova Technical Contract (NTC), would demonstrate (the Academy committee believed) that the physics of ignition targets was understood well enough that the laser requirements could be accurately specified. Completion of the NTC objectives was given the highest priority (it was Recommendation 1.1) in the NAS report. The NAS committee also recommended a concentrated effort on advanced target design for ignition. As recommended in the report, completion of these objectives has been the joint responsibility of LLNL and the Los Alamos National Laboratory. Most of the articles in this issue of the ICF Quarterly were written jointly by scientists from both institutions. The original NTC objectives have been largely met. This Introduction summarizes those objectives and their motivation in the context of the requirements for ignition.

  11. Dwarf nova outbursts with magnetorotational turbulence

    Science.gov (United States)

    Coleman, M. S. B.; Kotko, I.; Blaes, O.; Lasota, J.-P.; Hirose, S.

    2016-11-01

    The phenomenological disc instability model has been successful in reproducing the observed light curves of dwarf nova outbursts by invoking an enhanced Shakura-Sunyaev α parameter ˜0.1-0.2 in outburst compared to a low value ˜0.01 in quiescence. Recent thermodynamically consistent simulations of magnetorotational instability (MRI) turbulence with appropriate opacities and equation of state for dwarf nova accretion discs have found that thermal convection enhances α in discs in outburst, but only near the hydrogen ionization transition. At higher temperatures, convection no longer exists and α returns to the low value comparable to that in quiescence. In order to check whether this enhancement near the hydrogen ionization transition is sufficient to reproduce observed light curves, we incorporate this MRI-based variation in α into the disc instability model, as well as simulation-based models of turbulent dissipation and convective transport. These MRI-based models can successfully reproduce observed outburst and quiescence durations, as well as outburst amplitudes, albeit with different parameters from the standard disc instability models. The MRI-based model light curves exhibit reflares in the decay from outburst, which are not generally observed in dwarf novae. However, we highlight the problematic aspects of the quiescence physics in the disc instability model and MRI simulations that are responsible for this behaviour.

  12. A Thousand and One Nova Outbursts

    CERN Document Server

    Epchtein, N; Kovetz, A; Prialnik, D

    2006-01-01

    Multicycle nova evolution models have been calculated over the past twenty years, the number being limited by numerical constraints. Here we present a long-term evolution code that enables a continuous calculation through an unlimited number of nova cycles for an unlimited evolution time, even up to (or exceeding) a Hubble time. Starting with two sets of the three independent nova parameters -- the white dwarf mass, the temperature of its isothermal core, and the rate of mass transfer on to it -- we have followed the evolution of two models, with initial masses of 1 and 0.65 solar masses, accretion rates (constant throughout each calculation) of 1e-11 and 1e-9 solar-masses/yr, and relatively high initial temperatures (as they are likely to be at the onset of the outburst phase), through over 1000 and over 3000 cycles, respectively. The results show that although on the short-term consecutive outbursts are almost identical, on the long-term scale the characteristics change. This is mainly due to the changing c...

  13. Isolation of microRNA targets using biotinylated synthetic microRNAs

    DEFF Research Database (Denmark)

    Ørom, Ulf Andersson; Lund, Anders H

    2007-01-01

    MicroRNAs are small regulatory RNAs found in multicellular organisms where they post-transcriptionally regulate gene expression. In animals, microRNAs bind mRNAs via incomplete base pairings making the identification of microRNA targets inherently difficult. Here, we present a detailed method...... for experimental identification of microRNA targets based on affinity purification of tagged microRNAs associated with their targets. Udgivelsesdato: 2007-Oct...

  14. MicroRNA biomarkers in glioblastoma

    DEFF Research Database (Denmark)

    Hermansen, Simon Kjær; Kristensen, Bjarne Winther

    2013-01-01

    Recent research suggests that deregulation of microRNAs (miRNAs) is involved in initiation and progression of many cancers, including gliomas and that miRNAs hold great potential as future diagnostic and therapeutic tools in cancer. MiRNAs are a class of short non-coding RNA sequences (18......-24 nucleotides), which base-pair to target messenger RNA (mRNA) and thereby cause translational repression or mRNA degradation based on the level of complementarity between strands. Profiling miRNAs in clinical glioblastoma samples has shown aberrant expression of numerous miRNAs when compared to normal brain...... tissues. Understanding these alterations is key to developing new biomarkers and intelligent treatment strategies. This review presents an overview of current knowledge about miRNA alterations in glioblastoma while focusing on the clinical future of miRNAs as biomarkers and discussing the strengths...

  15. MicroRNA in Human Glioma

    Energy Technology Data Exchange (ETDEWEB)

    Li, Mengfeng, E-mail: limf@mail.sysu.edu.cn [Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China); Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Li, Jun [Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China); Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Lei; Li, Wei [Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China); Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Yang, Yi [Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China); Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Yuan, Jie [Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China); Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080 (China)

    2013-10-23

    Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy.

  16. MicroRNA Implication in Cancer

    Directory of Open Access Journals (Sweden)

    Iker BADIOLA

    2010-03-01

    Full Text Available MicroRNAs (miRNA are a new class of posttranscriptional regulators. These small non-coding RNAs regulate the expression of target mRNA transcripts and are linked to several human disease such as Alzheimer, cancer or heart disease. But it has been the cancer disease which has experimented the major number of studies of miRNA linked to the disease progression. In the last years it has been reported the deregulation pattern of the miRNAs in malignant cells which have disrupted the control of the proliferation, differentiation or apoptosis. The evidence of the presence of specific miRNA deregulated in concrete cancer types has become the miRNAs like possible biomarkers and therapeutic targets. The specific miRNA patterns deregulated in concrete cancer cell types open new opportunities to the diagnosis and therapy.

  17. [MicroRNAs and kidneys].

    Science.gov (United States)

    Stříteská, Jana; Nekvindová, Jana; Cerný, Vladimír; Palička, Vladimír

    2014-01-01

    MicroRNAs are short non-coding ribonucleic acid molecules that regulate gene expression at the post-transcriptional level thus affecting important physiological as well as pathophysiological processes in the organism, for example cell differentiation, proliferation, apoptosis, and metabolism. They are involved in pathogenesis of many diseases including cancer. Many microRNAs are tissue or organ-specific which implies their possible potential as biomarkers or maybe even therapeutical agents as documented by microRNA research interest rising exponentially during last years. Among all, microRNAs are important also for physiological function of the kidney and they are involved in various renal disorders. Today research is focused mainly on renal and urinary tract carcinogenesis, acute kidney injury, chronic renal diseases (polycystic kidney disease) or renal complications of systemic diseases such as diabetic or hypertension nephropathy and autoimmune kidney injury including acute allograft rejection after kidney transplantation. The review summarizes current information about microRNA effect on kidney development and function and also on the most common kidney diseases.

  18. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?

    Directory of Open Access Journals (Sweden)

    Enikö Sonkoly

    Full Text Available MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema. Among the psoriasis-specific microRNAs, we identified leukocyte-derived microRNAs and one keratinocyte-derived microRNA, miR-203. In a panel of 21 different human organs and tissues, miR-203 showed a highly skin-specific expression profile. Among the cellular constituents of the skin, it was exclusively expressed by keratinocytes. The up-regulation of miR-203 in psoriatic plaques was concurrent with the down-regulation of an evolutionary conserved target of miR-203, suppressor of cytokine signaling 3 (SOCS-3, which is involved in inflammatory responses and keratinocyte functions. Our results suggest that microRNA deregulation is involved in the pathogenesis of psoriasis and contributes to the dysfunction of the cross talk between resident and infiltrating cells. Taken together, a new layer of regulatory mechanisms is involved in the pathogenesis of chronic inflammatory skin diseases.

  19. Bossa Nova: Introducing modularity into the Bossa Nova domain-specific language

    DEFF Research Database (Denmark)

    Lawall, Julia Laetitia; Duschene, Hervé; Muller, Gilles;

    2005-01-01

    Domain-specific languages (DSLs) have been proposed as a solution to ease the development of programs within a program family. Sometimes, however, experience with the use of a DSL reveals the presence of subfamilies within the family targeted by the language. We are then faced with the question...... modular language, Bossa Nova, and assess the language quantitatively and qualitatively....

  20. Nova como sistema operativo embebido para hardware cubano Nova as embedded operating system for cuban hardware

    Directory of Open Access Journals (Sweden)

    José Ernesto Torres Sánchez

    2012-05-01

    Full Text Available Este trabajo expone los resultados de construir un sistema operativo embebido basado en Nova, el cual brinda las funcionalidades necesarias para crear el Cliente Ligero Cubano, utilizando como componente de hardware, la Computadora en una Tarjeta CID 300/9 diseñada por el Instituto Central de Investigación Digital. Obteniéndose la primera versión de Nova para la arquitectura de computadora Advanced RISC Machine y el primer sistema operativo base, estable y de propósito general para la CID 300/9. Se expone un estado del arte de los sistemas operativos embebidos más utilizados actualmente; la estructura de la solución, los métodos y herramientas empleados para obtenerla.This paper presents the results of the construction a an embedded operating system based on Nova, which provides the needed features to create the Cuban Thin Client, using as hardware component the Computer on a CID 300/9 Board designed by the Central Institute for Digital Research, obtaining the first version of Nova for the Advance RISC Machine  computer architecture and the first base operating system, stable and for general purposes for the CID 300/9. A state of the art of the currently most used embedded operating systems, the solution's structure, the methods and tools used for its development are presented.

  1. Nova as embedded operating system for cuban hardware Nova como sistema operativo embebido para hardware cubano

    Directory of Open Access Journals (Sweden)

    Mijail Hurtado Fedorovich

    2012-05-01

    Full Text Available This paper presents the results of the construction a an embedded operating system based on Nova, which provides the needed features to create the Cuban Thin Client, using as hardware component the Computer on a CID 300/9 Board designed by the Central Institute for Digital Research, obtaining the first version of Nova for the Advance RISC Machine  computer architecture and the first base operating system, stable and for general purposes for the CID 300/9. A state of the art of the currently most used embedded operating systems, the solution's structure, the methods and tools used for its development are presented. Este trabajo expone los resultados de construir un sistema operativo embebido basado en Nova, el cual brinda las funcionalidades necesarias para crear el Cliente Ligero Cubano, utilizando como componente de hardware, la Computadora en una Tarjeta CID 300/9 diseñada por el Instituto Central de Investigación Digital. Obteniéndose la primera versión de Nova para la arquitectura de computadora Advanced RISC Machine y el primer sistema operativo base, estable y de propósito general para la CID 300/9. Se expone un estado del arte de los sistemas operativos embebidos más utilizados actualmente; la estructura de la solución, los métodos y herramientas empleados para obtenerla.

  2. Explosive lithium production in the classical nova V339 Del (Nova Delphini 2013)

    CERN Document Server

    Tajitsu, Akito; Naito, Hiroyuki; Arai, Akir; Aoki, Wako

    2015-01-01

    The origin of lithium (Li) and its production process have long been an unsettled question in cosmology and astrophysics. Candidates environments of Li production events or sites suggested by previous studies include big bang nucleosynthesis, interactions of energetic cosmic rays with interstellar matter, evolved low mass stars, novae, and supernova explosions. Chemical evolution models and observed stellar Li abundances suggest that at least half of the present Li abundance may have been produced in red giants, asymptotic giant branch (AGB) stars, and novae. However, no direct evidence for the supply of Li from stellar objects to the Galactic medium has yet been found. Here we report on the detection of highly blue-shifted resonance lines of the singly ionized radioactive isotope of beryllium, $^{7}$Be, in the near ultraviolet (UV) spectra of the classical nova V339 Del (Nova Delphini 2013). Spectra were obtained 38 to 48 days after the explosion. $^{7}$Be decays to form $^{7}$Li within a short time (half-li...

  3. V4743 Sgr, a magnetic nova?

    Science.gov (United States)

    Zemko, P.; Orio, M.; Mukai, K.; Bianchini, A.; Ciroi, S.; Cracco, V.

    2016-08-01

    Two XMM-Newton observations of Nova V4743 Sgr (Nova Sgr 2002) were performed shortly after it returned to quiescence, 2 and 3.5 yr after the explosion. The X-ray light curves revealed a modulation with a frequency of ≃0.75 mHz, indicating that V4743 Sgr is most probably an intermediate polar (IP). The X-ray spectra have characteristics in common with known IPs, with a hard thermal plasma component that can be fitted only assuming a partially covering absorber. In 2004, the X-ray spectrum had also a supersoft blackbody-like component, whose temperature was close to that of the white dwarf (WD) in the supersoft X-ray phase following the outburst, but with flux by at least two orders of magnitude lower. In quiescent IPs, a soft X-ray flux component originates at times in the polar regions irradiated by an accretion column, but the supersoft component of V4743 Sgr disappeared in 2006, indicating a possible origin different from accretion. We suggest that it may have been due to an atmospheric temperature gradient on the WD surface, or to continuing localized thermonuclear burning at the bottom of the envelope, before complete turn-off. An optical spectrum obtained with Southern African Large Telescope (SALT) 11.5 yr after the outburst showed a prominent He II λ4686 line and the Bowen blend, which reveal a very hot region, but with peak temperature shifted to the ultraviolet range. V4743 Sgr is the third post-outburst nova and IP candidate showing a low-luminosity supersoft component in the X-ray flux a few years after the outburst.

  4. ECONOMIA SOCIAL INCORPORATIVA (e as novas linguagens

    Directory of Open Access Journals (Sweden)

    Welinton dos Santos

    2017-05-01

    Full Text Available A inovação tecnológica aliada à interação de comunicação sem limites, chamada de “Economia Social Incorporativa”, sendo uma rede integrada e sociável as populações do mundo. Baseada em uma pesquisa bibliográfica de caráter qualitativo e documental mostrando que a comunicação, informações e tecnologias evoluem surgindo novos materiais em destaque o grafeno, composto por átomos de carbono com alta condutividade térmica e elétrica, flexível e resistente, material que pode substituir o silício e permitir a segunda revolução tecnológica e levando consigo a economia. Com esses feitos tecnológicos a humanidade tende a estar mais do que nunca com uma ligação inseparável das novas tecnologias que vem aparecendo de forma exponencial no mercado estimulando assim mais do que nunca a economia social. O futuro visa uma nova economia que está em transformação, provocando mudanças significativas na política econômica mundial, e por isso, todos os esforços nesta nova dinâmica de conscientização do comportamento social integrativo auxilia numa política estratégica global mais justa e igualitária.

  5. Supernova hydrodynamics experiments using the Nova laser

    Energy Technology Data Exchange (ETDEWEB)

    Remington, B.A.; Glendinning, S.G.; Estabrook, K.; Wallace, R.J.; Rubenchik, A. [Lawrence Livermore National Lab., CA (United States); Kane, J.; Arnett, D. [Arizona Univ., Tucson, AZ (United States). Stewart Observatory; Drake, R.P. [Michigan Univ., Ann Arbor, MI (United States); McCray, R. [Colorado Univ., Boulder, CO (United States)

    1997-04-01

    We are developing experiments using the Nova laser to investigate two areas of physics relevant to core-collapse supernovae (SN): (1) compressible nonlinear hydrodynamic mixing and (2) radiative shock hydrodynamics. In the former, we are examining the differences between the 2D and 3D evolution of the Rayleigh-Taylor instability, an issue critical to the observables emerging from SN in the first year after exploding. In the latter, we are investigating the evolution of a colliding plasma system relevant to the ejecta-stellar wind interactions of the early stages of SN remnant formation. The experiments and astrophysical implications are discussed.

  6. As novas estruturas organizacionais das bolsas

    OpenAIRE

    Marcos Galileu Lorena Dutra

    2008-01-01

    O presente trabalho investiga as novas estruturas organizacionais das bolsas de valores e das bolsas de mercadorias e futuros, implementadas após os processos de desmutualização. É feita uma análise da importância das bolsas para o desenvolvimento econômico, bem como do seu papel de entidades auto-reguladoras. São ainda apresentados os principais fatores que motivaram a conversão das bolsas de associações mutualísticas para sociedades anônimas, bem como as conseqüências dessa alteração organi...

  7. 10% discount at Novae restaurants for students

    CERN Multimedia

    2016-01-01

    A 10% discount will be granted for students dining in restaurants 1 and 2 (on the Meyrin site) during the summer from 15 June 2016 to 15 September 2016.   A special badge will be issued by the respective secretariats if the student fulfils the following criteria:  Is under 25 years old; Is in possession of a student card issued by a University or college; Has a CERN contract > 1 month (Users, Summer Students, Trainees, etc). This badge and the CERN access card will have to be shown at the Novae restaurants in order to benefit from this discount.

  8. As novas estruturas organizacionais das bolsas

    OpenAIRE

    Marcos Galileu Lorena Dutra

    2008-01-01

    O presente trabalho investiga as novas estruturas organizacionais das bolsas de valores e das bolsas de mercadorias e futuros, implementadas após os processos de desmutualização. É feita uma análise da importância das bolsas para o desenvolvimento econômico, bem como do seu papel de entidades auto-reguladoras. São ainda apresentados os principais fatores que motivaram a conversão das bolsas de associações mutualísticas para sociedades anônimas, bem como as conseqüências dessa alteração organi...

  9. Combinatorial microRNA target predictions

    DEFF Research Database (Denmark)

    Krek, Azra; Grün, Dominic; Poy, Matthew N.

    2005-01-01

    MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3' untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript1, 2, 3. Different combinations of microRNAs are expressed...... in different cell types and may coordinately regulate cell-specific target genes. Here, we present PicTar, a computational method for identifying common targets of microRNAs. Statistical tests using genome-wide alignments of eight vertebrate genomes, PicTar's ability to specifically recover published micro......RNA targets, and experimental validation of seven predicted targets suggest that PicTar has an excellent success rate in predicting targets for single microRNAs and for combinations of microRNAs. We find that vertebrate microRNAs target, on average, roughly 200 transcripts each. Furthermore, our results...

  10. Novas Perspectivas em Educação e Saúde

    Directory of Open Access Journals (Sweden)

    Ivonaldo Leite

    2010-11-01

    Full Text Available

    class="MsoNormal" style="text-align: justify;">O artigo tem como objetivo descrever as novas relações entre educação e saúde. Assim, metodologicamente, é feita uma revisão bibliográfica de livros e artigos sobre esse tema. Como resultado, constata-se que têm sido desenvolvidas novas perspectivas sobre a formação profissional em saúde. Por exemplo, há uma tendência de aumento da oferta da formação contínua. Entre as suas conclusões, o artigo afirma que as novas perspectivas acerca da formação profissional em saúde valorizam a contribuição acadêmica das ciências humanas. 

  11. Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice

    NARCIS (Netherlands)

    Bluml, S.; Bonelli, M.; Niederreiter, B.; Puchner, A.; Mayr, G.; Hayer, S.; Koenders, M.I.; Berg, W.B. van den; Smolen, J.; Redlich, K.

    2011-01-01

    OBJECTIVE: MicroRNAs (miRNA) are a new class of regulatory elements. Altered expression of miRNA has been demonstrated in the inflamed joints of patients with rheumatoid arthritis (RA). The aim of this study was to examine the role of miRNA in the pathogenesis of autoimmune arthritis, using 2 murine

  12. Cardiac Regeneration and microRNAs : Regulators of Pluripotency, Reprogramming, and Cardiovascular Lineage Commitment

    NARCIS (Netherlands)

    Doeleman, Martijn J. H.; Feyen, DAM; de Veij Mestdagh, Christina F.; Sluijter, JPG

    2016-01-01

    microRNAs (miRNAs) are a small class of ~22 nucleotide long RNAs, which control gene expression through repression of mRNA translation and induction of mRNA decay. One miRNA can potentially target up to several hundred mRNAs, which makes miRNAs powerful regulators of gene expression patterns rather

  13. Cardiac Regeneration and microRNAs : Regulators of Pluripotency, Reprogramming, and Cardiovascular Lineage Commitment

    NARCIS (Netherlands)

    Doeleman, Martijn J. H.; Feyen, DAM; de Veij Mestdagh, Christina F.; Sluijter, JPG

    2016-01-01

    microRNAs (miRNAs) are a small class of ~22 nucleotide long RNAs, which control gene expression through repression of mRNA translation and induction of mRNA decay. One miRNA can potentially target up to several hundred mRNAs, which makes miRNAs powerful regulators of gene expression patterns rather

  14. The Nova Rate in M94 (NGC4736)

    CERN Document Server

    Gueth, T; Misselt, K A

    2010-01-01

    A multi-epoch H$\\alpha$ survey of the early-type spiral galaxy M94 (NGC 4736) has been completed as part of a program to establish the galaxy's nova rate. A total of 4 nova candidates were discovered in 7 epochs of observation during the period from 2005 to 2007. After making corrections for temporal coverage and spatial completeness, a global nova rate of 5.0$^{+1.8}_{-1.4}$ yr$^{-1}$ was determined. This rate corresponds to a specific-luminosity nova rate of 1.4 $\\pm$ 0.5 novae per year per 10$^{10} L_{\\odot,K}$ when the K luminosity is determined from the B - K color, or 1.5 $\\pm$ 0.4 novae per year per 10$^{10} L_{\\odot,K}$ when the K luminosity is derived from the Two Micron All Sky Survey. These values are slightly lower than that of other galaxies with measured nova rates, which typically lie in the range of 2-3 novae per year per 10$^{10} L_{\\odot}$ in the K band.

  15. The progenitor of Nova Cygni 2006 (=V2362 Cyg)

    NARCIS (Netherlands)

    Steeghs, D.; Greimel, R.; Drew, J.; Irwin, M.; Gaensicke, B.; Groot, P.J.; Knigge, C.

    2006-01-01

    We report on the detection of the likely progenitor to Nova Cygni 2006 = V2362 Cyg (IAUC #8697, #8698, ATel #792) using images from the INT Photometric H-Alpha Survey (IPHAS; http://www.iphas.org). The field containing the classical nova was observed as part of our galactic plane survey on Aug. 3rd

  16. Some misapplied nomina nova in reef coral taxonomy (Scleractinia)

    NARCIS (Netherlands)

    Hoeksema, B.W.

    1993-01-01

    Nomina nova should be used only to denote replacement names for preoccupied names, i.e. in the case of homonymy. Three examples of incorrect applications of nomina nova in scleractinian taxonomy are given. Coincidentally, in the cases discussed each wrongly proposed nomen novum concerns a new specie

  17. Results of Statewide TerraNova Testing, Fall 1998.

    Science.gov (United States)

    La Marca, Paul M.

    This summary provides key findings about state, district, and school level performance on the TerraNova examinations (CTB/McGraw Hill) in Nevada in 1998-1999. The TerraNova tests are used to assess students in grades 4, 8, and 10 as stipulated by Nevada law. Within this summary, a description of performance as measured by national percentile…

  18. NOVA: a software to analyze complexome profiling data

    NARCIS (Netherlands)

    Giese, H.; Ackermann, J.; Heide, H.; Bleier, L.; Drose, S.; Wittig, I.; Brandt, U.; Koch, I.

    2015-01-01

    SUMMARY: We introduce nova, a software for the analysis of complexome profiling data. nova supports the investigation of the composition of complexes, cluster analysis of the experimental data, visual inspection and comparison of experiments and many other features. AVAILABILITY AND IMPLEMENTATION:

  19. Legislating Interprofessional Regulatory Collaboration in Nova Scotia

    Directory of Open Access Journals (Sweden)

    William Lahey

    2013-10-01

    Full Text Available To shift health professions regulation from traditional to ‘collaborative’ self-regulation, Nova Scotia has adopted legislation which will: make all self-regulating health professions members of the Regulated Health Professions Network; mandate the Network to facilitate voluntary collaboration among its members; and enable regulators to work together on investigations of patient complaints, to adjust scopes of practice on an ongoing basis and to adjudicate appeals of unsuccessful applicants for registration. The goals are to give health professions regulation the capacity to enable and support the functioning of interprofessional teams. The legislation was adopted primarily for two reasons: collaborative development and unanimous support by all of the province’s self-regulating professions; and alignment with the government’s health care reform agenda and its emphasis on collaborative team-based care. Contrary to the approach of several other provinces, the legislation will enable but not require regulators to collaborate on the premise that consensual collaboration is more likely to happen, to be meaningful and to yield tangible benefits. Support for this approach can be taken from the impressive collaborative work on which the legislation is based. Evaluation will be critical, and the five-year review required by the legislation will give Nova Scotia the opportunity to test not only the legislation but the ideas on which it is based. The extent of the legislation’s reliance on voluntary process will prove to be either its greatest strength or its greatest weakness.

  20. Characterization of Dwarf Novae Using SDSS Colors

    CERN Document Server

    Kato, Taichi; Uemura, Makoto

    2011-01-01

    We have developed a method for estimating orbital periods of dwarf novae from SDSS colors in quiescence using an artificial neural network. For typical objects below the period gap with good photometric accuracy, we could estimate orbital periods to a 1-sigma error of 22%. The error of estimation is worse for systems with longer periods. We have also developed a neural network-based method for categorical classification. This method has been proven to be efficient in classifying objects into three categories (WZ Sge-type, SU UMa-type and SS Cyg/Z Cam-type) and works for very faint objects down to g=21. Using these methods, we have investigated the distribution of orbital periods of dwarf novae from a modern transient survey (Catalina Real-Time Survey). Using Bayesian analysis developed by Uemura et al. (2010, arXiv:1003.0945), the present sample tends to give a flatter distribution toward the shortest period and a shorter estimate of the period minimum, which may have been resulted from the uncertainties in t...

  1. The nature and evolution of Nova Cygni 2006

    CERN Document Server

    Munari, U; Henden, A; Cardarelli, G; Cherini, G; Dallaporta, S; Via, G Dalla; Frigo, A; Jurdana-Sepic, R; Moretti, S; Ochner, P; Tomaselli, S; Tomasoni, S; Valisa, P; Navasardyan, H; Valentini, M

    2008-01-01

    AIMS: Nova Cyg 2006 has been intensively observed throughout its full outburst. We investigate the energetics and evolution of the central source and of the expanding ejecta, their chemical abundances and ionization structure, and the formation of dust. METHOD: We recorded low, medium, and/or high-resolution spectra (calibrated into accurate absolute fluxes) on 39 nights, along with 2353 photometric UBVRcIc measures on 313 nights, and complemented them with IR data from the literature. RESULTS: The nova displayed initially the normal photometric and spectroscopic evolution of a fast nova of the FeII-type. Pre-maximum, principal, diffuse-enhanced, and Orion absorption systems developed in a normal way. After the initial outburst, the nova progressively slowed its fading pace until the decline reversed and a second maximum was reached (eight months later), accompanied by large spectroscopic changes. Following the rapid decline from second maximum, the nova finally entered the nebular phase and formed optically ...

  2. The Early Spectral Evolution of the Classical Nova ASASSN-15th in M33

    Science.gov (United States)

    Wagner, R. Mark; Neric, Marko; Darnley, Matt J.; Williams, Steven; Starrfield, Sumner; Woodward, Charles E.; Prieto, Jose Luis

    2016-06-01

    During the course of the All Sky Automated Survey for SuperNovae (ASAS-SN) a new transient source designated ASASSN-15th was identified on images of the nearby galaxy M33 obtained with the 14 cm Brutus telescope in Haleakala, Hawaii on 2015 Dec 1.4 UT at V ~ 16.5 mag. Given the location of the transient in M33 and its apparent V magnitude at discovery, the implied absolute visual magnitude was about -8.5 mag suggesting that the transient was a new classical nova outburst in M33. Optical spectroscopy obtained by us on 2015 Dec 2.3 showed broad emission lines of Balmer, Fe II, and Na I D with P Cygni-type line profiles superposed on a blue continuum. The spectrum was consistent with a Fe II-type classical nova in M33 discovered early in the outburst. Subsequent spectra obtained by us on 2015 Dec 10.9 UT showed significant evolution since our first spectrum in that the deep P Cygni-type line profiles seen earlier were now extremely shallow or had almost completely disappeared with the emission component growing in strength. Additional emission lines from O I, Si II, and possibly He I were also present. We obtained optical spectroscopy of ASASSN-15th on 17 epochs between 2015 Dec 1 and 2016 Feb 11 UT with the 2.4 m Hiltner telescope (+OSMOS) of the MDM Observatory, the 2 m fully robotic Liverpool Telescope (+SPRAT), and the 2 x 8.4 m Large Binocular Telescope (+MODS). We will present our spectroscopy and discuss the early evolution of ASASSN-15th in the context of Galactic Fe II-class novae.

  3. The enigmatic outburst of V445 Puppis - A possible helium nova?

    Science.gov (United States)

    Ashok, N. M.; Banerjee, D. P. K.

    2003-10-01

    JHK spectroscopic and photometric observations are reported for the enigmatic, nova-like, variable V445 Puppis which erupted at the end of 2000. The near-IR spectra are hydrogen-deficient and unusually rich in CI lines. The important CI lines are found to be positioned at 1.133, 1.166, 1.175, 1.189, 1.26 and 1.689 mu m. Model calculations for the CI lines are done to make the identification of the lines secure. Photometric data, taken on January 2.90 UT, 2001 shortly after the outburst, show the formation of an optically thin dust shell around V445 Puppis. The temperature and upper limit for the mass of the dust shell are estimated to be 1800 K and Mdust ~ 10-9 Msun respectively. A subsequent episode of massive dust formation - indicated by the observed, deep visual dimming - is also seen in JHK images of early November 2001. V445 Puppis has shown two unusual properties for a nova: (i) the hydrogen-deficiency and He/C enrichment of the object as seen from optical and IR data and (ii) synchrotron radio emission which was detected nearly a year after its outburst by other workers. The strange nature of the object is discussed and it is shown that it is difficult to place it in the known categories of eruptive variables viz. novae (classical, recurrent or symbiotic); born-again AGB stars; the new class of eruptive variables like V838 Mon; and RCB/HdC stars. Tentative evidence for an accretion disk and binarity of the V445 Puppis system is presented. It is debated whether V445 Puppis is a rare helium nova or a unique object.

  4. Observations and simulations of nova Vul 1984 no. 2: A nova with ejecta rich in oxygen, neon, and magnesium

    Science.gov (United States)

    Starrfield, S.; Sonneborn, G.; Stryker, L. L.; Sparks, Warren M.; Truran, James W.; Ferland, Gary; Wagner, R. M.; Gallagher, J. S.; Wade, R.; Williams, R. E.

    1988-01-01

    Nova Vul 1984 no. 2 was observed with IUE from Dec. 1984 through Nov. 1987. The spectra are characterized by strong lines from Mg, Ne, C, Si, O, N, and other elements. Data obtained in the ultraviolet, infrared, and optical show that this nova is ejecting material rich in oxygen, neon, and magnesium.

  5. Identification of Novel and Conserved microRNAs in Homalodisca vitripennis, the Glassy-Winged Sharpshooter by Expression Profiling.

    Directory of Open Access Journals (Sweden)

    Raja Sekhar Nandety

    Full Text Available The glassy-winged sharpshooter (GWSS Homalodisca vitripennis (Hemiptera: Cicadellidae, is a xylem-feeding leafhopper and an important vector of the bacterium Xylella fastidiosa; the causal agent of Pierce's disease of grapevines. MicroRNAs are a class of small RNAs that play an important role in the functional development of various organisms including insects. In H. vitripennis, we identified microRNAs using high-throughput deep sequencing of adults followed by computational and manual annotation. A total of 14 novel microRNAs that are not found in the miRBase were identified from adult H. vitripennis. Conserved microRNAs were also found in our datasets. By comparison to our previously determined transcriptome sequence of H. vitripennis, we identified the potential targets of the microRNAs in the transcriptome. This microRNA profile information not only provides a more nuanced understanding of the biological and physiological mechanisms that govern gene expression in H. vitripennis, but may also lead to the identification of novel mechanisms for biorationally designed management strategies through the use of microRNAs.

  6. The panchromatic spectroscopic evolution of the classical CO nova V339 Del (Nova Del 2013) until X-ray turnoff

    CERN Document Server

    Shore, S N; Schwarz, G J; Teyssier, F M; Buil, C; Aquino, I De Gennaro; Page, K L; Osborne, J P; Scaringi, S; Starrfield, S; van Winckel, H; Williams, R E; Woodward, C E

    2016-01-01

    Classical novae are the product of thermonuclear runaway-initiated explosions occurring on accreting white dwarfs. V339 Del (Nova Delphinus 2013) was one of the brightest classical novae of the last hundred years. Spectroscopy and photometry are available from $\\gamma$-rays through infrared at stages that have frequently not been well observed. The complete data set is intended to provide a benchmark for comparison with modeling and for understanding more sparsely monitored historical classical and recurrent novae. This paper is the first in the series of reports on the development of the nova. We report here on the early stages of the outburst, through the X-ray active stage. A time sequence of optical, flux calibrated high resolution spectra was obtained with the Nordic Optical Telescope (NOT) using FIES simultaneously, or contemporaneously, with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope during the early stages of the outburst. These were supplemented with MERCATOR/HE...

  7. Regulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy.

    Science.gov (United States)

    Klimczak, Dominika; Jazdzewski, Krystian; Kuch, Marek

    2017-02-01

    Multiple factors underlie the pathophysiology of hypertension, involving endothelial dysregulation, vascular smooth muscle dysfunction, increased oxidative stress, sympathetic nervous system activation and altered renin -angiotensin -aldosterone regulatory activity. A class of non-coding RNA called microRNA, consisting of 17-25 nucleotides, exert regulatory function over these processes. This paper summarizes the currently available data from preclinical and clinical studies on miRNA in the development of hypertension as well as the impact of anti-hypertensive treatment on their plasma expression. We present microRNAs' characteristics, their biogenesis and role in the regulation of blood pressure together with their potential diagnostic and therapeutic application in clinical practice.

  8. Nova Scotia Power response to Hurricane Juan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-10-01

    Hurricane Juan hit the Halifax Regional Municipality on September 28, 2003, creating the largest outage in Nova Scotia Power's history. This detailed report documents the extensive damage that Hurricane Juan caused to the power transmission and distribution system in Nova Scotia. It also reviews the massive power restoration effort, with reference to numerous interviews, computer records and data logs which offer a wide range of observations, statistics and insights into the preparation and performance of Nova Scotia Power Inc. (NSPI) and the efforts of other key organizations following the storm. NSPI organized a recovery effort that matched the intensity of the hurricane. A fire in the Scotia Square Office Tower caused the evacuation of the company's call centre. The Tufts Cove station in Dartmouth, which generates 400 megawatts of power, was forced to shut down. Excess electricity was moved into New Brunswick and other jurisdictions to maintain system stability. The main priority was to restore customers back to service. Within 5 days of the hurricane, 95 per cent of those who lost power had service restored. Hurricane Juan caused the most damage to the transmission and distribution system in NSPI's history. Three out of five high capacity transmission lines were put out of service. Three 120-foot high transmission towers fell, and 17 main transmission lines were damaged and put out of service. Forty-five major substations were affected and 145 distribution feeders were damaged or tripped off, including 106 in the Halifax Regional Municipality. Large portions of 4,500 kilometres of local distribution lines in the Halifax Regional Municipality were damaged, including thousands of kilometers across the Northeast. The power crew, consisting of 2,000 individuals from the region and neighbouring utilities in New Brunswick and Maine, worked for 15 consecutive days to replace 275 transformers, 760 power poles, and 125,000 metres of conductor wire. NSPI

  9. Ciberespaço: nova realidade, novos perigos, novas formas de defesa

    Directory of Open Access Journals (Sweden)

    Ana Maria Nicolaci-da-Costa

    Full Text Available A mídia, nacional e internacional, vem divulgando à exaustão vários tipos de perigo que supostamente rondam a utilização da Internet. Por trás dessa divulgação, parece estar um pressuposto que desafia a Psicologia: o de que somos indefesos para lidar com a nova realidade do ciberespaço. Resultados inesperados de uma pesquisa sobre o uso intensivo da Internet, no entanto, mostram o contrário. A partir destes, novas estratégias de auto-proteção online, que visam principalmente à preservação da intimidade, puderam ser identificadas. Essas estratégias envolvem diferentes formas de utilização, por parte dos usuários, dos próprios programas e recursos tecnológicos disponíveis.

  10. Urinary microRNA can be concentrated, dried on membranes and stored at room temperature in vacuum bags

    Directory of Open Access Journals (Sweden)

    Fanshuang Zhang

    2015-07-01

    Full Text Available Urine accumulates traces of changes that occur in the body and can potentially serve as a better biomarker source. Urinary microRNA is a promising class of non-invasive disease biomarkers. However, long-term frozen human urine samples are not a good source for the extraction of urinary microRNA. In this paper, we demonstrate that urinary microRNA can be concentrated, dried on membranes and stored in vacuum bags at room temperature for several months. The amount of total RNA on the membranes after storage at room temperature for three months was unchanged. The levels of miR-16 and miR-21 exhibited no significant differences (P = 0.564, 0.386. This simple and economical method makes the large-scale storage of clinical samples of urinary microRNA or other nucleic acids possible.

  11. The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright.

    Science.gov (United States)

    Yu, Kangkang; Shi, Guangfeng; Li, Ning

    2015-01-01

    MicroRNAs represent a class of non-coding RNA molecules that negatively regulate gene expression either by repressing translation or by inducing degradation of messenger RNA. Studies have shown that, as regulators of gene expression, microRNAs are widely involved in various human diseases, including hepatitis B virus-related liver diseases. By modulating hepatitis B virus replication, regulating extracellular matrix formation, as well as silencing tumor suppressor genes, these small molecules are implicated in the development of chronic hepatitis, liver fibrosis/cirrhosis, and hepatocellular carcinoma caused by hepatitis B virus infection. In addition, current researches indicated a potential role of microRNA as diagnostic markers and therapeutic targets. In conclusion, microRNAs are promising tools in the diagnosis and treatment of hepatitis B virus -related liver diseases.

  12. Laying the foundation for a digital Nova Scotia

    Science.gov (United States)

    Bond, J.

    2016-04-01

    In 2013, the Province of Nova Scotia began an effort to modernize its coordinate referencing infrastructure known as the Nova Scotia Coordinate Referencing System (NSCRS). At that time, 8, active GPS stations were installed in southwest Nova Scotia to evaluate the technology's ability to address the Province's coordinate referencing needs. The success of the test phase helped build a business case to implement the technology across the entire Province. It is anticipated that by the end of 2015, 40 active GPS stations will be in place across Nova Scotia. This infrastructure, known as the Nova Scotia Active Control Stations (NSACS) network, will allow for instantaneous, centimetre level positioning across the Province. Originally designed to address the needs of the surveying community, the technology has also proven to have applications in mapping, machine automation, agriculture, navigation, emergency response, earthquake detection and other areas. In the foreseeable future, all spatial data sets captured in Nova Scotia will be either directly or indirectly derived from the NSACS network. The technology will promote high accuracy and homogenous spatial data sets across the Province. The technology behind the NSACS and the development of the system are described. Examples of how the technology is contributing to a digital Nova Scotia are presented. Future applications of the technology are also considered.

  13. OGLE Atlas of Classical Novae II. Magellanic Clouds

    CERN Document Server

    Mroz, P; Poleski, R; Soszynski, I; Szymanski, M K; Pietrzynski, G; Wyrzykowski, L; Ulaczyk, K; Kozlowski, S; Pietrukowicz, P; Skowron, J

    2016-01-01

    The population of classical novae in the Magellanic Clouds was poorly known because of a lack of systematic studies. There were some suggestions that nova rates per unit mass in the Magellanic Clouds were higher than in any other galaxy. Here, we present an analysis of data collected over sixteen years by the OGLE survey with the aim of characterizing nova population in the Clouds. We found twenty eruptions of novae, half of them are new discoveries. We robustly measure the nova rates of $2.4 \\pm 0.8$ yr$^{-1}$ (LMC) and $0.9 \\pm 0.4$ yr$^{-1}$ (SMC) and confirm that K-band luminosity-specific nova rates in both Clouds are 2-3 times higher than in other galaxies. This can be explained by the star formation history in the Magellanic Clouds, specifically a re-ignition of the star formation rate a few Gyr ago. We also present the discovery of an intriguing system OGLE-MBR133.25.1160 which mimics recurrent nova eruptions.

  14. OGLE Atlas of Classical Novae. II. Magellanic Clouds

    Science.gov (United States)

    Mróz, P.; Udalski, A.; Poleski, R.; Soszyński, I.; Szymański, M. K.; Pietrzyński, G.; Wyrzykowski, Ł.; Ulaczyk, K.; Kozłowski, S.; Pietrukowicz, P.; Skowron, J.

    2016-01-01

    The population of classical novae in the Magellanic Clouds was poorly known because of a lack of systematic studies. There were some suggestions that nova rates per unit mass in the Magellanic Clouds were higher than in any other galaxy. Here, we present an analysis of data collected over 16 years by the OGLE survey with the aim of characterizing the nova population in the Clouds. We found 20 eruptions of novae, half of which are new discoveries. We robustly measure nova rates of 2.4 ± 0.8 yr-1 (LMC) and 0.9 ± 0.4 yr-1 (SMC) and confirm that the K-band luminosity-specific nova rates in both Clouds are 2-3 times higher than in other galaxies. This can be explained by the star formation history in the Magellanic Clouds, specifically the re-ignition of the star formation rate a few Gyr ago. We also present the discovery of the intriguing system OGLE-MBR133.25.1160, which mimics recurrent nova eruptions.

  15. The Unusually Luminous Extragalactic Nova SN 2010U

    CERN Document Server

    Czekala, Ian; Chornock, R; Pastorello, A; Marion, G H; Margutti, R; Botticella, M T; Challis, P; Ergon, M; Smartt, S; Sollerman, J; Vinkó, J; Wheeler, J C

    2012-01-01

    We present observations of the unusual optical transient SN 2010U, including spectra taken 1.03 days to 15.3 days after maximum light that identify it as a fast and luminous Fe II type nova. Our multi-band light curve traces the fast decline (t_2 = 3.5 days) from maximum light (M_V = -10.2 mag), placing SN 2010U in the top 0.5% of the most luminous novae ever observed. We find typical ejecta velocities of approximately 1100 km/s and that SN 2010U shares many spectral and photometric characteristics with two other fast and luminous Fe II type novae, including Nova LMC 1991 and M31N-2007-11d. For the extreme luminosity of this nova, the maximum magnitude vs. rate of decline relationship indicates a massive white dwarf progenitor with a low pre-outburst accretion rate. However, this prediction is in conflict with emerging theories of nova populations, which predict that luminous novae from massive white dwarfs should preferentially exhibit an alternate spectral type (He/N) near maximum light.

  16. CLIP Identifies Nova-Regulated RNA Networks in the Brain

    Science.gov (United States)

    Ule, Jernej; Jensen, Kirk B.; Ruggiu, Matteo; Mele, Aldo; Ule, Aljaž; Darnell, Robert B.

    2003-11-01

    Nova proteins are neuron-specific antigens targeted in paraneoplastic opsoclonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhibition. Nova proteins regulate neuronal pre-messenger RNA splicing by directly binding to RNA. To identify Nova RNA targets, we developed a method to purify protein-RNA complexes from mouse brain with the use of ultraviolet cross-linking and immunoprecipitation (CLIP). Thirty-four transcripts were identified multiple times by Nova CLIP. Three-quarters of these encode proteins that function at the neuronal synapse, and one-third are involved in neuronal inhibition. Splicing targets confirmed in Nova-/- mice include c-Jun N-terminal kinase 2, neogenin, and gephyrin; the latter encodes a protein that clusters inhibitory γ-aminobutyric acid and glycine receptors, two previously identified Nova splicing targets. Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA.

  17. MESA and NuGrid Simulations of Classical Nova Outbursts: ONe Nova and Nucleosynthesis

    CERN Document Server

    Denissenkov, Pavel A; Pignatari, Marco; Trappitsch, Reto; Ritter, Christian; Herwig, Falk; Battino, Umberto; Setoodehnia, Kiana

    2013-01-01

    Classical novae are the result of thermonuclear flashes of H accreted by CO or ONe white dwarfs, leading eventually to the dynamic ejection of the surface layers. These are observationally known to be enriched in heavy elements, such as C, O and Ne that must originate in layers below the H-flash convection zone. Building on our previous work we now present stellar evolution simulations of ONe nova, and provide a comprehensive comparison of our models with previous work. Some of our models include exponential convective boundary mixing model to account for the observed enrichment of the ejecta even when accreting material with a solar abundance distribution. Our models produce maximum temperature evolution profiles and nucleosynthesis yields in good agreement with models that generate enriched ejecta by assuming that the accreted material was pre-enriched. We confirm for ONe nova the result we reported previously, i.e. we found that 3He can be produced in situ in solar-composition envelopes accreted with slow ...

  18. Experimental identification of microRNA targets

    DEFF Research Database (Denmark)

    Ørom, Ulf Andersson; Lund, Anders H

    2009-01-01

    microRNAs are small RNAs that regulate protein synthesis post-transcriptionally. Animal microRNAs recognize their targets by incomplete base pairing to sequence motifs most often present in the 3' untranslated region of their target mRNAs. This partial complementarity vastly expands the repertoire...... of potential targets and constitutes a problem for computational target prediction. Although computational analyses have shed light on important aspects of microRNA target recognition, several questions remain regarding how microRNAs can recognize and regulate their targets. Forward experimental approaches...... allow for an unbiased study of microRNA target recognition and may unveil novel, rare or uncommon target binding patterns. In this review we focus on animal microRNAs and the experimental approaches that have been described for identification of their targets....

  19. Nova abordagem no tratamento da esquizofrenia

    Directory of Open Access Journals (Sweden)

    Walter Speltri

    1966-12-01

    Full Text Available Foram tratados 11 casos de esquizofrenia com a guanetidina, substância considerada, do ponto de vista farmacodinâmico, como simpaticoplégica. Na opinião do autor, os surpreendentes e significativos resultados obtidos autorizam uma nova abordagem nas pesquisas à procura da etiopatogenia da esquizofrenia e, a partir dos elementos colhidos, considera plausível uma "teoria psicossomática da esquizofrenia". Recusa-se, entretanto, a cair no atraente, mas inútil, terreno especulativo. Prefere aguardar que os farmacologistas e fisiologistas forneçam dados pais precisos sobre o mecanismo de ação da guanetidina e que novos estudos confirmem seus resultados para, depois, dar publicidade à sua teoria.

  20. Novas tecnologias: Novos Professores? Novos Saberes?

    Directory of Open Access Journals (Sweden)

    Daniele Cristina Mendes

    2008-11-01

    Full Text Available RESUMO:A integração da educação com a informação-comunicação precisa ter seu lugar repensado dentro das escolas. Neste artigo tento instigar reflexões no trato das questões referentes às novas tecnologias e suas implicações na leitura, na linguagem e na formação dos professores.PALAVRAS-CHAVE: Leitura, Internet, Formação DocenteABSTRACT:The integration of education with the information and communication, must have rethought its place within the schools. In this article I try to instigate reflections on issues concerning the treatment of new technologies and their implications for reading, in language and training of teachers.KEYWORDS: Reading, Internet, Teacher educationRecebido: 30/10/2008     Aceito:30/11/2008

  1. La nova identitat visual de la EAP

    Directory of Open Access Journals (Sweden)

    Dario D. Aguillón Gutiérrez

    2015-01-01

    Full Text Available L'Escola d'Arts Plàstiques de la Universitat Autònoma de Coahuila, a Mèxic, ha estat durant dècades una de les institucions d'ensenyament d'art i disseny més importants al nord del país. Les seves necessitats de comunicació actuals, així com la seva constant creixement, van fer necessari el disseny d'una nova identitat visual, coherent amb la seva personalitat i conscient de l'entorn en què es desenvolupa. Aquest projecte va ser realitzat entre directius, docents i estudiants de l'Escola d'Arts Plàstiques, amb l'objectiu de dotar la institució d'una identitat pròpia i professional.

  2. MiR-181b-5p downregulates NOVA1 to suppress proliferation, migration and invasion and promote apoptosis in astrocytoma.

    Directory of Open Access Journals (Sweden)

    Feng Zhi

    Full Text Available MicroRNAs (miRNAs are small, short noncoding RNAs that modulate the expression of numerous genes by targeting their mRNA. Numerous abnormal miRNA expression patterns are observed in various human malignancies, and certain miRNAs can act as oncogenes or tumor suppressors. Astrocytoma, the most common neuroepithelial cancer, represents the majority of malignant brain tumors in humans. In our previous studies, we found that the downregulation of miR-181b-5p in astrocytomas is associated with a poor prognosis. The aim of the present study was to investigate the functional role of miR-181b-5p and its possible target genes. miR-181b-5p was significantly downregulated in astrocytoma specimens, and the reduced expression of miR-181b-5p was inversely correlated with the clinical stage. The ectopic expression of miR-181b-5p inhibited proliferation, migration and invasion and induced apoptosis in astrocytoma cancer cells in vitro. The NOVA1 (neuro-oncological ventral antigen 1 gene was further identified as a novel direct target of miR-181b-5p. Specifically, miR-181b-5p bound directly to the 3'-untranslated region (UTR of NOVA1 and suppressed its expression. In clinical specimens, NOVA1 was overexpressed, and its protein levels were inversely correlated with miR-181b-5p expression. Furthermore, the changing level of NOVA1 was significantly associated with a poor survival outcome. Similar to restoring miR-181b-5p expression, downregulating NOVA1 inhibited cell growth, migration and invasion. Overexpression of NOVA1 reversed the inhibitory effects of miR-181b-5p. Our results indicate that miR-181b-5p is a tumor suppressor in astrocytoma that inhibits tumor progression by targeting NOVA1. These findings suggest that miR-181b-5p may serve as a novel therapeutic target for astrocytoma.

  3. MiR-181b-5p downregulates NOVA1 to suppress proliferation, migration and invasion and promote apoptosis in astrocytoma.

    Science.gov (United States)

    Zhi, Feng; Wang, Qiang; Deng, Danni; Shao, Naiyuan; Wang, Rong; Xue, Lian; Wang, Suinuan; Xia, Xiwei; Yang, Yilin

    2014-01-01

    MicroRNAs (miRNAs) are small, short noncoding RNAs that modulate the expression of numerous genes by targeting their mRNA. Numerous abnormal miRNA expression patterns are observed in various human malignancies, and certain miRNAs can act as oncogenes or tumor suppressors. Astrocytoma, the most common neuroepithelial cancer, represents the majority of malignant brain tumors in humans. In our previous studies, we found that the downregulation of miR-181b-5p in astrocytomas is associated with a poor prognosis. The aim of the present study was to investigate the functional role of miR-181b-5p and its possible target genes. miR-181b-5p was significantly downregulated in astrocytoma specimens, and the reduced expression of miR-181b-5p was inversely correlated with the clinical stage. The ectopic expression of miR-181b-5p inhibited proliferation, migration and invasion and induced apoptosis in astrocytoma cancer cells in vitro. The NOVA1 (neuro-oncological ventral antigen 1) gene was further identified as a novel direct target of miR-181b-5p. Specifically, miR-181b-5p bound directly to the 3'-untranslated region (UTR) of NOVA1 and suppressed its expression. In clinical specimens, NOVA1 was overexpressed, and its protein levels were inversely correlated with miR-181b-5p expression. Furthermore, the changing level of NOVA1 was significantly associated with a poor survival outcome. Similar to restoring miR-181b-5p expression, downregulating NOVA1 inhibited cell growth, migration and invasion. Overexpression of NOVA1 reversed the inhibitory effects of miR-181b-5p. Our results indicate that miR-181b-5p is a tumor suppressor in astrocytoma that inhibits tumor progression by targeting NOVA1. These findings suggest that miR-181b-5p may serve as a novel therapeutic target for astrocytoma.

  4. Newly Identified Rydberg Emission Lines in Novae

    Science.gov (United States)

    Lynch, David K.; Rudy, R. J.; Bernstein, L. S.

    2008-09-01

    Newly Identified Rydberg Emission Lines in Novae David K. Lynch, Richard. J. Rudy (The Aerospace Corporation) & Lawrence S. Bernstein (Spectral Sciences, Inc.) Novae spectra in the near infrared frequently show a set of six emission lines that have not been positively identified (Williams, Longmore, & Geballe 1996, MNRAS, 279, 804; Lynch et al. 2001, AJ, 122, 2013; Rudy et al. 2002 ApJ, 573, 794; Lynch et al. 2004 Astron. J. 127, 1089-1097). These lines are at 0.8926, 1.1114, 1.1901, 1.5545, 2.0996 and 2.425 µm ± 0.005 µm. Krautter et al. (1984 A&A 137, 304) suggested that three of the lines were due to rydberg (hydrogenic) transitions in an unspecified atomic species that was in the 4th or 5th ionization stage (core charge = 4 & 5). We believe that Krautter et al.'s explanation is correct based on 4 additional lines that we have identified in the visible and near infrared spectrum of V723 Cassiopeiae. The observed Rydberg lines appear to originate from high angular momentum states with negligible quantum defects. The species cannot be determined with any certainty because in rydberg states, the outer electron sees a nucleus shielded by the inner electrons and together the inner atom appears to have a charge of +1, like hydrogen. As a result, the atom looks hydrogenic and species such as CV, NV, OV, MgV, SiV, etc. have their rydberg transitions at very similar wavelengths. All the lines represent permitted transitions, most likely formed by recombination. Atoms with core charges 4, 5 & 6 are rarely seen in the astrophysical environment because an extremely hot radiation field is necessary to ionize them. Thermonuclear runaways on the surface of a white dwarf can reach millions of degrees K, and thus there are enough X-ray photons available to achieve the necessary high ionization levels.

  5. Light Curve Analysis of Neon Novae

    CERN Document Server

    Hachisu, Izumi

    2015-01-01

    We analyzed light curves of five neon novae, QU Vul, V351 Pup, V382 Vel, V693 CrA, and V1974 Cyg, and determined their white dwarf (WD) masses and distance moduli on the basis of theoretical light curves composed of free-free and photospheric emission. For QU Vul, we obtained a distance of d~2.4 kpc, reddening of E(B-V)~0.55, and WD mass of M_WD=0.82-0.96 M_sun. This suggests that an oxygen-neon WD lost a mass of more than ~0.1 M_sun since its birth. For V351 Pup, we obtained d~5.5 kpc, E(B-V)~0.45, and M_WD=0.98-1.1 M_sun. For V382 Vel, we obtained d~1.6 kpc, E(B-V)~0.15, and M_WD=1.13-1.28 M_sun. For V693 CrA, we obtained d~7.1 kpc, E(B-V)~0.05, and M_WD=1.15-1.25 M_sun. For V1974 Cyg, we obtained d~1.8 kpc, E(B-V)~0.30, and M_WD=0.95-1.1 M_sun. For comparison, we added the carbon-oxygen nova V1668 Cyg to our analysis and obtained d~5.4 kpc, E(B-V)~0.30, and M_WD=0.98-1.1 M_sun. In QU Vul, photospheric emission contributes 0.4-0.8 mag at most to the optical light curve compared with free-free emission only....

  6. Therapeutic implications of microRNAs in human cancer

    OpenAIRE

    Michael Rossbach

    2011-01-01

    MicroRNAs (miRNAs) are a class of highly evolutionarily conserved non-coding RNAs (ncRNAs) that modulate gene expression. Several studies have shown that the expression of miRNAs is deregulated in human malignancies. For ncRNAs and miRNAs, such gene-profiling studies in tumorigenic tissues have identified significant signatures that are of both diagnostic and prognostic value. Addressing the functions of ncRNAs not only give insights into the molecular mechanisms that underlie complex genetic...

  7. Tumor suppressor p53 meets microRNAs

    OpenAIRE

    2011-01-01

    Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function through transcription regulation of its target genes to initiate various cellular responses. To maintain its proper function, p53 is tightly regulated by a wide variety of regulators in cells. Thus, p53, its regulators and regulated genes form a complex p53 network which is composed of hundreds of genes and their products. microRNAs (miRNAs) are a class of endogenously expr...

  8. A Mathematical Model for MicroRNA in Lung Cancer

    OpenAIRE

    Kang, Hye-Won; Crawford, Melissa; Fabbri, Muller; Nuovo, Gerard; Garofalo, Michela; Nana-Sinkam, S Patrick; Friedman, Avner

    2013-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. Lack of early detection and limited options for targeted therapies are both contributing factors to the dismal statistics observed in lung cancer. Thus, advances in both of these areas are likely to lead to improved outcomes. MicroRNAs (miRs or miRNAs) represent a class of non-coding RNAs that have the capacity for gene regulation and may serve as both diagnostic and prognostic biomarkers in lung cancer. Abnormal expression ...

  9. Micromanagement of the immune system by microRNAs.

    Science.gov (United States)

    Lodish, Harvey F; Zhou, Beiyan; Liu, Gwen; Chen, Chang-Zheng

    2008-02-01

    MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved small non-coding RNAs that are thought to control gene expression by targeting mRNAs for degradation or translational repression. Emerging evidence suggests that miRNA-mediated gene regulation represents a fundamental layer of genetic programmes at the post-transcriptional level and has diverse functional roles in animals. Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses.

  10. MicroRNAs of parasites: current status and future perspectives.

    Science.gov (United States)

    Liu, Quan; Tuo, Wenbin; Gao, Hongwei; Zhu, Xing-Quan

    2010-08-01

    MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs regulating gene expression in eukaryotes at the post-transcriptional level. The complex life cycles of parasites may require the ability to respond to environmental and developmental signals through miRNA-mediated gene expression. Over the past 17 years, thousands of miRNAs have been identified in the nematode Caenorhabditis elegans and other parasites. Here, we review the current status and potential functions of miRNAs in protozoan, helminths, and arthropods, and propose some perspectives for future studies.

  11. Circulating microRNAs: Novel biomarkers for esophageal cancer

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Esophageal carcinogenesis is a multi-stage process, involving a variety of changes in gene expression and physiological structure change. MicroRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules. Recent innovation in miRNAs profiling technology have shed new light on the pathology of esophageal carcinoma (EC), and also heralded great potential for exploring novel biomarkers for both EC diagnosis and treatment. Frequent dysregulation of miRNA in malignancy highlights the study of molecular...

  12. Ultraviolet spectroscopy of old novae and symbiotic stars

    Science.gov (United States)

    Lambert, D. L.; Slovak, M. H.; Shields, G. A.; Ferland, G. J.

    1981-01-01

    The IUE spectra are presented for two old novae and for two of the symbiotic variables. Prominent emission line spectra are revealed as a continuum whose appearance is effected by the system inclination. These data provide evidence for hot companions in the symbiotic stars, making plausible the binary model for these peculiar stars. Recent IUE spectra of dwarf novae provide additional support for the existence of optically thick accretion disks in active binary systems. The ultraviolet data of the eclipsing dwarf novae EX Hya and BV Cen appear flatter than for the noneclipsing systems, an effect which could be ascribed to the system inclination.

  13. Distributed computer control system in the Nova Laser Fusion Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    1985-09-01

    The EE Technical Review has two purposes - to inform readers of various activities within the Electronics Engineering Department and to promote the exchange of ideas. The articles, by design, are brief summaries of EE work. The articles included in this report are as follows: Overview - Nova Control System; Centralized Computer-Based Controls for the Nova Laser Facility; Nova Pulse-Power Control System; Nova Laser Alignment Control System; Nova Beam Diagnostic System; Nova Target-Diagnostics Control System; and Nova Shot Scheduler. The 7 papers are individually abstracted.

  14. Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae

    Directory of Open Access Journals (Sweden)

    Podolska Agnieszka

    2012-09-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are a class of non-protein-coding genes that play a crucial regulatory role in mammalian development and disease. Whereas a large number of miRNAs have been annotated at the structural level during the latest years, functional annotation is sparse. Actinobacillus pleuropneumoniae (APP causes serious lung infections in pigs. Severe damage to the lungs, in many cases deadly, is caused by toxins released by the bacterium and to some degree by host mediated tissue damage. However, understanding of the role of microRNAs in the course of this infectious disease in porcine is still very limited. Results In this study, the RNA extracted from visually unaffected and necrotic tissue from pigs infected with Actinobacillus pleuropneumoniae was subjected to small RNA deep sequencing. We identified 169 conserved and 11 candidate novel microRNAs in the pig. Of these, 17 were significantly up-regulated in the necrotic sample and 12 were down-regulated. The expression analysis of a number of candidates revealed microRNAs of potential importance in the innate immune response. MiR-155, a known key player in inflammation, was found expressed in both samples. Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection. Conclusions This is the first study revealing significant differences in composition and expression profiles of miRNAs in lungs infected with a bacterial pathogen. Our results extend annotation of microRNA in pig and provide insight into the role of a number of microRNAs in regulation of bacteria induced immune and inflammatory response in porcine lung.

  15. MicroRNAs take part in pathophysiology and pathogenesis of Male Pattern Baldness.

    Science.gov (United States)

    Goodarzi, Hamed R; Abbasi, Ali; Saffari, Mojtaba; Tabei, Mohammad B; Noori Daloii, Mohammad R

    2010-07-01

    Male Pattern Baldness (MPB) or androgenetic alopecia is a common form of hair loss with androgens and genetics having etiological significance. Androgens are thought to pathophysiologically power on cascades of chronically dramatic alterations in genetically susceptible scalp dermal papillas, specialized cells in hair follicles in which androgens react, and finally resulting in a patterned alopecia. However, the exact mechanisms through which androgens, positive regulators of growth and anabolism in most body sites, paradoxically exert their effects on balding hair follicles, are not yet known. The role of microRNAs, a recently discovered class of non-coding RNAs, with a wide range of regulatory functions, has been documented in hair follicle formation and their deregulation in cancer of prostate, a target organ of androgens has also been delineated. Yet, there is a lack of knowledge in agreement with microRNAs' contribution in pathophysiology of MPB. To investigate the role of microRNAs in pathogenesis of MPB, we selected seven microRNAs, predicted bioinformatically on a reverse engineering basis, from previously published microarray gene expression data and analyzed their expression in balding relative to non-balding dermal papillas. We found for the first time upregulation of four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB. Regarding microRNAs' therapeutic potential and accessibility of hair follicles for gene therapy, these microRNAs can be considered as good candidates for a new revolutionized generation of treatments.

  16. Very high energy gamma-ray follow-up observations of novae and dwarf novae with the MAGIC telescopes

    CERN Document Server

    López-Coto, R; Bednarek, W; Desiante, R; Longo, F

    2015-01-01

    In the last few years the Fermi-LAT instrument has detected GeV gamma-ray emission from several novae. Such GeV emission can be interpreted in terms of inverse Compton emission from electrons accelerated in the shock or in terms of emission from hadrons accelerated in the same conditions. The latter might reach much higher energies and could produce a second component in the gamma-ray spectrum at TeV energies. We perform follow-up observations of selected novae and dwarf novae in search of the second component in TeV energy gamma rays. This can shed light on the acceleration process of leptons and hadrons in nova explosions. We have performed observations with the MAGIC telescopes of 3 sources, a symbiotic nova YY Her, a dwarf nova ASASSN-13ax and a classical nova V339 Del, shortly after their outbursts. We did not detect TeV gamma-ray emission from any of the objects observed. The TeV upper limits from MAGIC observations and the GeV detection by Fermi constrain the acceleration parameters for electrons and h...

  17. Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae

    DEFF Research Database (Denmark)

    Podolska, Agnieszka; Anthon, Christian; Bak, Mads

    2012-01-01

    Background: MicroRNAs (miRNAs) are a class of non-protein-coding genes that play a crucial regulatory role in mammalian development and disease. Whereas a large number of miRNAs have been annotated at the structural level during the latest years, functional annotation is sparse. Actinobacillus...... pleuropneumoniae (APP) causes serious lung infections in pigs. Severe damage to the lungs, in many cases deadly, is caused by toxins released by the bacterium and to some degree by host mediated tissue damage. However, understanding of the role of microRNAs in the course of this infectious disease in porcine......R-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection. Conclusions: This is the first study revealing significant differences in composition and expression profiles of miRNAs in lungs infected with a bacterial pathogen. Our results extend...

  18. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

    OpenAIRE

    Chen, Jian-Fu; Mandel, Elizabeth M.; Thomson, J. Michael; WU, QIULIAN; Callis, Thomas E.; Hammond, Scott M.; Conlon, Frank L.; Wang, Da-Zhi

    2005-01-01

    Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class of regulatory RNAs of ~22 nucleotides that post-transcriptionally regulate gene expression1,2. Increasing evidence points to the potential role of miRNAs in various biological processes3–8. Here we show that miRNA-1 (miR-1) and miRNA-133 (miR-133), which are clustered on the same chromosomal loci, are transcribed together i...

  19. "Racializing" Class

    Science.gov (United States)

    Hatt-Echeverria, Beth; Urrieta, Luis, Jr.

    2003-01-01

    In an effort to explore how racial and class oppressions intersect, the authors use their autobiographical narratives to depict cultural and experiential continuity and discontinuity in growing up white working class versus Chicano working class. They specifically focus on "racializing class" due to the ways class is often used as a copout by…

  20. Clinical applications of microRNAs [v2; ref status: indexed, http://f1000r.es/1o3

    Directory of Open Access Journals (Sweden)

    Per Hydbring

    2013-08-01

    Full Text Available MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. The primary transcript forms one or several bulging double stranded hairpins which are processed by Drosha and Dicer into hetero-duplexes. The targeting microRNA strand of the duplex is incorporated into the RNA Induced Silencing Complex from where it silences up to hundreds of mRNA transcript by inducing mRNA degradation or blocking protein translation. Apart from involvement in a variety of biological processes, microRNAs were early recognized for their potential in disease diagnostics and therapeutics. Due to their stability, microRNAs could be used as biomarkers. Currently, there are microRNA panels helping physicians determining the origins of cancer in disseminated tumors. The development of microRNA therapeutics has proved more challenging mainly due to delivery issues. However, one drug is already in clinical trials and several more await entering clinical phases. This review summarizes what has been recognized pre-clinically and clinically on diagnostic microRNAs. In addition, it highlights individual microRNA drugs in running platforms driven by four leading microRNA-therapeutic companies.

  1. MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    C. Nelson Hayes

    2016-02-01

    Full Text Available Serum levels of liver enzymes, such as alanine transaminase, aspartate transaminase, and α-fetoprotein, provide insight into liver function and are used during treatment of liver disease, but such information is limited. In the case of hepatocellular carcinoma (HCC, which is often not detected until an advanced stage, more sensitive biomarkers may help to achieve earlier detection. Serum also contains microRNAs, a class of small non-coding RNAs that play an important role in regulating gene expression. miR-122 is specific to the liver and correlates strongly with liver enzyme levels and necroinflammatory activity, and other microRNAs are correlated with the degree of fibrosis. miR-122 has also been found to be required for hepatitis C virus (HCV infection, whereas other microRNAs have been shown to play antiviral roles. miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV transcripts, and others are up- or down-regulated in infected individuals. MicroRNA profiles also differ in the case of HBV and HCV infection as well as between HBeAg-positive and negative patients, and in patients with occult versus active HBV infection. In such patients, monitoring of changes in microRNA profiles might provide earlier warning of neoplastic changes preceding HCC.

  2. The Role of microRNAs in the Biology of Rare Diseases

    Directory of Open Access Journals (Sweden)

    Domenica Taruscio

    2011-10-01

    Full Text Available Rare diseases (RD are characterized by low prevalence and affect not more than five individuals per 10,000 in the European population; they are a large and heterogeneous group of disorders including more than 7,000 conditions and often involve all organs and tissues, with several clinical subtypes within the same disease. Very often information concerning either diagnosis and/or prognosis on many RD is insufficient. microRNAs are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level by either degrading or blocking translation of messenger RNA targets. Recently, microRNA expression patterns of body fluids underscored their potential as noninvasive biomarkers for various diseases. The role of microRNAs as potential biomarkers has become particularly attractive. The identification of disease-related microRNAs is essential for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. Computational analysis of microRNA-disease associations is an important complementary means for prioritizing microRNAs for further experimental examination. In this article, we explored the added value of miRs as biomarkers in a selected panel of RD hitting different tissues/systems at different life stages, but sharing the need of better biomarkers for diagnostic and prognostic purposes.

  3. Ontology-oriented retrieval of putative microRNAs in Vitis vinifera via GrapeMiRNA: a web database of de novo predicted grape microRNAs

    Directory of Open Access Journals (Sweden)

    Fontana Paolo

    2009-06-01

    Full Text Available Abstract Background Two complete genome sequences are available for Vitis vinifera Pinot noir. Based on the sequence and gene predictions produced by the IASMA, we performed an in silico detection of putative microRNA genes and of their targets, and collected the most reliable microRNA predictions in a web database. The application is available at http://www.itb.cnr.it/ptp/grapemirna/. Description The program FindMiRNA was used to detect putative microRNA genes in the grape genome. A very high number of predictions was retrieved, calling for validation. Nine parameters were calculated and, based on the grape microRNAs dataset available at miRBase, thresholds were defined and applied to FindMiRNA predictions having targets in gene exons. In the resulting subset, predictions were ranked according to precursor positions and sequence similarity, and to target identity. To further validate FindMiRNA predictions, comparisons to the Arabidopsis genome, to the grape Genoscope genome, and to the grape EST collection were performed. Results were stored in a MySQL database and a web interface was prepared to query the database and retrieve predictions of interest. Conclusion The GrapeMiRNA database encompasses 5,778 microRNA predictions spanning the whole grape genome. Predictions are integrated with information that can be of use in selection procedures. Tools added in the web interface also allow to inspect predictions according to gene ontology classes and metabolic pathways of targets. The GrapeMiRNA database can be of help in selecting candidate microRNA genes to be validated.

  4. MicroRNA and cancer

    DEFF Research Database (Denmark)

    Jansson, Martin D; Lund, Anders H

    2012-01-01

    biological phenomena and pathologies. The best characterized non-coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human diseases such as cancer. In this review, we...... summarize the current knowledge and concepts concerning the involvement of microRNAs in cancer, which have emerged from the study of cell culture and animal model systems, including the regulation of key cancer-related pathways, such as cell cycle control and the DNA damage response. Importantly, microRNA......With the advent of next generation sequencing techniques a previously unknown world of non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential...

  5. The spectroscopic evolution of the $\\gamma$-ray emitting classical nova Nova Mon 2012. I. Implications for the ONe subclass of classical novae

    CERN Document Server

    Shore, S N; Schwarz, G J; Augusteijn, T; Cheung, C C; Walter, F M; Starrfield, S

    2013-01-01

    Nova Mon 2012 was the first classical nova to be detected as a high energy $\\gamma$-ray transient, by Fermi-LAT, before its optical discovery. We study a time sequence of high resolution optical echelle spectra (Nordic Optical Telescope) and contemporaneous NOT, STIS UV, and CHIRON echelle spectra (Nov 20/21/22). We use [O III] and H$\\beta$ line fluxs to constrain the properties of the ejecta. We derive the structure from the optical and UV line profiles and compare our measured line fluxes for with predictions using Cloudy with abundances from other ONe novae. Mon 2012 is confirmed as an ONe nova. We find E(B-V)=0.85$\\pm$0.05 and hydrogen column density $\\approx 5\\times 10^{21}$ cm$^{-2}$. The corrected continuum luminosity is nearly the same in the entire observed energy range as V1974 Cyg, V382 Mon, and Nova LMC 2000 at the same epoch after outburst. The distance, about 3.6 kpc, is quite similar to V1974 Cyg. The line profiles can be modeled using an axisymmetric bipolar geometry for the ejecta with variou...

  6. Ocean and Coastal Acidification off New England and Nova Scotia

    Science.gov (United States)

    New England coastal and adjacent Nova Scotia shelf waters have a reduced buffering capacity because of significant freshwater input, making the region’s waters potentially more vulnerable to coastal acidification. Nutrient loading and heavy precipitation events further acid...

  7. Gamma-ray emission from individual classical novae

    CERN Document Server

    Gómez-Gomar, J; José, J; Isern, J

    1997-01-01

    Classical novae are important producers of radioactive nuclei, such as be7, n13, f18, na22 and al26. The disintegration of these nuclei produces positrons (except for be7) that through annihilation with electrons produce photons of energies 511 keV and below. Furthermore, be7 and na22 decay producing photons with energies of 478 keV and 1275 keV, respectively, well in the gamma-ray domain. Therefore, novae are potential sources of gamma-ray emission. The properties of gamma-ray spectra and gamma-ray light curves (for the continuum and for the lines at 511, 478 and 1275 keV) have been analyzed, with a special emphasis on the difference between carbon-oxygen and oxygen-neon novae. Predictions of detectability of individual novae by the future SPI spectrometer on board the INTEGRAL satellite are made.

  8. Ocean and Coastal Acidification off New England and Nova Scotia

    Science.gov (United States)

    New England coastal and adjacent Nova Scotia shelf waters have a reduced buffering capacity because of significant freshwater input, making the region’s waters potentially more vulnerable to coastal acidification. Nutrient loading and heavy precipitation events further acid...

  9. A Comprehensive Review of Nova-Like Variable Stars

    Science.gov (United States)

    Sion, Edward

    2016-07-01

    A comprehensive review of nova-like variable stars of the VY Sculptoris and UX Ursa Majoris subtypes is presented. All that has been learned, up to the present time, from observations in the X-ray, far ultraviolet, optical and infrared bandpasses will be discussed. Spectroscopic analyses of high optical brightness states and low optical brightness states of nova-like variables will be summarized. The application of standard and non-standard accretion disk models as well as boundary layer structure will be discussed. The results of searches for nova shells, the evolutionary state of nova-likes as well as new spectroscopic results on BZ Cam (the bow shock CV) and BB Dor will also be included. This work is supported by NASA ADP grants NNX13AF12G and NNX13AF11G to Villanova University.

  10. The Place of Recurrent Novae among the Symbiotic Stars

    CERN Document Server

    Mikolajewska, Joanna

    2008-01-01

    The observational properties of recurrent novae indicate that they can be divided into two subclasses:systems with a dwarf and a red giant secondary, respectively. The second type -- which includes RS Oph -- bears many similarities to symbiotic stars.

  11. Quark nova inside supernova: Application to GRBs and XROs

    CERN Document Server

    Staff, Jan

    2010-01-01

    In this paper we consider a quark nova occurring inside an exploding star. The quark nova ejecta will shock when interacting with the stellar envelope. When this shock reaches the surface of the star, the energy is radiated away. We suggest that this energy may be seen in X-rays, and show here that this may explain some flares seen in the X-ray afterglow of long gamma ray bursts (GRBs). A quark nova inside an exploding star need not be followed by a GRB, or the GRB may not be beamed towards us. However, the shock breakout is likely not beamed and could be seen even in the absence of a GRB. We suggest that XRO 080109 is such an event in which a quark nova occurs inside an exploding star. No GRB is formed, but the break out of the shock leads to the XRO.

  12. Toward the promise of microRNAs - Enhancing reproducibility and rigor in microRNA research.

    Science.gov (United States)

    Witwer, Kenneth W; Halushka, Marc K

    2016-11-01

    The fields of applied and translational microRNA research have exploded in recent years as microRNAs have been implicated across a spectrum of diseases. MicroRNA biomarkers, microRNA therapeutics, microRNA regulation of cellular physiology and even xenomiRs have stimulated great interest, which have brought many researchers into the field. Despite many successes in determining general mechanisms of microRNA generation and function, the application of microRNAs in translational areas has not had as much success. It has been a challenge to localize microRNAs to a given cell type within tissues and assay them reliably. At supraphysiologic levels, microRNAs may regulate hosts of genes that are not the physiologic biochemical targets. Thus the applied and translational microRNA literature is filled with pitfalls and claims that are neither scientifically rigorous nor reproducible. This review is focused on increasing awareness of the challenges of working with microRNAs in translational research and recommends better practices in this area of discovery.

  13. AAS Nova and Astrobites: Making current astronomy research accessible

    Science.gov (United States)

    Kohler, Susanna; Astrobites Team

    2016-10-01

    AAS Nova and Astrobites are two resources available for astronomers, astronomy students, and astronomy enthusiasts to keep up with some of the most recent research published across the field of astronomy. Both supported by the AAS, these two daily astrophysical literature blogs provide accessible summaries of recent publications on the arXiv and in AAS journals. We present the goals, content, and readership of AAS Nova and Astrobites, and discuss how they might be used as tools in the undergraduate classroom.

  14. Synthesis of C-rich dust in CO nova outbursts

    Science.gov (United States)

    José, Jordi; Halabi, Ghina M.; El Eid, Mounib F.

    2016-09-01

    Context. Classical novae are thermonuclear explosions that take place in the envelopes of accreting white dwarfs in stellar binary systems. The material transferred onto the white dwarf piles up under degenerate conditions, driving a thermonuclear runaway. In these outbursts, about 10-7-10-3 M⊙, enriched in CNO and sometimes other intermediate-mass elements (e.g., Ne, Na, Mg, or Al for ONe novae) are ejected into the interstellar medium. The large concentrations of metals spectroscopically inferred in the nova ejecta reveal that the solar-like material transferred from the secondary mixes with the outermost layers of the underlying white dwarf. Aims: Most theoretical models of nova outbursts reported to date yield, on average, outflows characterized by O > C, from which, in principle, only oxidized condensates (e.g., O-rich grains) would be expected. Methods: To specifically address whether CO novae can actually produce C-rich dust, six different hydrodynamic nova models have been evolved, from accretion to the expansion and ejection stages, with different choices for the composition of the substrate with which the solar-like accreted material mixes. Updated chemical profiles inside the H-exhausted core have been used, based on stellar evolution calculations for a progenitor of 8 M⊙ through H- and He-burning phases. Results: We show that these profiles lead to C-rich ejecta after the nova outburst. This extends the possible contribution of novae to the inventory of presolar grains identified in meteorites, particularly in a number of carbonaceous phases (i.e., nanodiamonds, silicon carbides, and graphites).

  15. Dwarf nova-type cataclysmic variable stars are significant radio emitters

    CERN Document Server

    Coppejans, Deanne L; Miller-Jones, James C A; Rupen, Michael P; Sivakoff, Gregory R; Knigge, Christian; Groot, Paul J; Woudt, Patrick A; Waagen, Elizabeth O; Templeton, Matthew

    2016-01-01

    We present 8--12\\,GHz radio light curves of five dwarf nova (DN) type Cataclysmic Variable stars (CVs) in outburst (RX And, U Gem and Z Cam), or superoutburst (SU UMa and YZ Cnc), increasing the number of radio-detected DN by a factor of two. The observed radio emission was variable on time-scales of minutes to days, and we argue that it is likely to be synchrotron emission. This sample shows no correlation between the radio luminosity and optical luminosity, orbital period, CV class, or outburst type; however higher-cadence observations are necessary to test this, as the measured luminosity is dependent on the timing of the observations in these variable objects. The observations show that the previously detected radio emission from SS Cyg is not unique in type, luminosity (in the plateau phase of the outburst), or variability time-scales. Our results prove that DN, as a class, are radio emitters in outburst.

  16. Synthesis of C-rich dust in CO nova ourbursts

    CERN Document Server

    Jose, Jordi; Eid, Mounib F El

    2016-01-01

    Context. Classical novae are thermonuclear explosions that take place in the envelopes of accreting white dwarfs in stellar binary systems. The material transferred onto the white dwarf piles up under degenerate conditions, driving a thermonuclear runaway. In those outbursts, about 10-7 - 10-3 Msun, enriched in CNO and, sometimes, other intermediate-mass elements (e.g., Ne, Na, Mg, or Al, for ONe novae) are ejected into the interstellar medium. The large concentrations of metals spectroscopically inferred in the nova ejecta reveal that the (solar-like) material transferred from the secondary mixes with the outermost layers of the underlying white dwarf. Aims. Most theoretical models of nova outbursts reported to date yield, on average, outflows characterized by O > C, from which only oxidized condensates (e.g, O-rich grains) would be expected, in principle. Methods. To specifically address whether CO novae can actually produce C-rich dust, six different hydrodynamic nova models have been evolved, from accreti...

  17. Another neon nova - Early infrared photometry and spectroscopy of Nova Cygni 1992

    Science.gov (United States)

    Hayward, T. L.; Gehrz, R. D.; Miles, J. W.; Houck, J. R.

    1992-01-01

    Infrared photometry and spectrophotometry of Nova Cygni 1992 taken within 54 days of its eruption show a strong 12.8-micron Ne II forbidden emission line as well as hydrogen recombination lines. Spectra with lambda/Delta lambda of about 2000 resolve the Ne II forbidden and 12.37-micron Hu-alpha lines with about 2200 km/s (FWHM). The Ne II forbidden line shows multiple velocity components. The amount of forbidden Ne II required to produce the observed emission feature exceeds the solar abundance of neon by at least a factor of 4.

  18. SIRT1 and microRNA

    Directory of Open Access Journals (Sweden)

    Munekazu eYamakuchi

    2012-03-01

    Full Text Available SIRT1 is an NAD-dependent deacetylase that regulates the cellular response to stressors. SIRT1 is intensively studied as a potental regulator of cellular metabolism and longevity. Pathways of SIRT1 regulation may lead to a greater understanding of metabolism and aging. Post-transcriptional regulation of SIRT1 is mediated by two classes of molecules, RNA-binding proteins and non-coding small RNAs. MicroRNAs (miRNAs are short non-coding RNAs that regulate target gene expression in a post-transcriptional manner. More than 10 miRNAs modulate SIRT1 expression, including miR-34a. MiR-34a induces colon cancer apoptosis through SIRT1, and miR-34a also promotes senescence in endothelial cells via SIRT1. In this review, I describe the impact of miRNAs on SIRT1. First I outline the background of SIRT1 and miRNAs, then I demonstrate the mechanism by which several key miRNAs alter SIRT1 levels. I focus on the modulation of SIRT1 function by these miRNAs in the cardiovascular systems, metabolic pathway and cancer. Next I address the regulatory mechanism of SIRT1 by another important molecule, a RNA-binding protein HuR, which associates with SIRT1 mRNA and regulates its expression.

  19. Cancer Cachexia and MicroRNAs.

    Science.gov (United States)

    Camargo, Rodolfo Gonzalez; Quintas Teixeira Ribeiro, Henrique; Geraldo, Murilo Vieira; Matos-Neto, Emídio; Neves, Rodrigo Xavier; Carnevali, Luiz Carlos; Donatto, Felipe Fedrizzi; Alcântara, Paulo S M; Ottoch, José P; Seelaender, Marília

    2015-01-01

    Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment.

  20. MicroRNAs regulate osteogenesis and chondrogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Shiwu, E-mail: shiwudong@gmail.com [Laboratory of Biomechanics, Department of Anatomy, The Third Military Medical University, Chongqing (China); Yang, Bo; Guo, Hongfeng; Kang, Fei [Laboratory of Biomechanics, Department of Anatomy, The Third Military Medical University, Chongqing (China)

    2012-02-24

    Highlights: Black-Right-Pointing-Pointer To focus on the role of miRNAs in chondrogenesis and osteogenesis. Black-Right-Pointing-Pointer Involved in the regulation of miRNAs in osteoarthritis. Black-Right-Pointing-Pointer To speculate some therapeutic targets for bone diseases. -- Abstract: MicroRNAs (miRNAs) are a class of small molecules and non-coding single strand RNAs that regulate gene expression at the post-transcriptional level by binding to specific sequences within target genes. miRNAs have been recognized as important regulatory factors in organism development and disease expression. Some miRNAs regulate the proliferation and differentiation of osteoblasts, osteoclasts and chondrocytes, eventually influencing metabolism and bone formation. miRNAs are expected to provide potential gene therapy targets for the clinical treatment of metabolic bone diseases and bone injuries. Here, we review the recent research progress on the regulation of miRNAs in bone biology, with a particular focus on the miRNA-mediated control mechanisms of bone and cartilage formation.

  1. The microRNA toolkit of insects

    Science.gov (United States)

    Ylla, Guillem; Fromm, Bastian; Piulachs, Maria-Dolors; Belles, Xavier

    2016-01-01

    Is there a correlation between miRNA diversity and levels of organismic complexity? Exhibiting extraordinary levels of morphological and developmental complexity, insects are the most diverse animal class on earth. Their evolutionary success was in particular shaped by the innovation of holometabolan metamorphosis in endopterygotes. Previously, miRNA evolution had been linked to morphological complexity, but astonishing variation in the currently available miRNA complements of insects made this link unclear. To address this issue, we sequenced the miRNA complement of the hemimetabolan Blattella germanica and reannotated that of two other hemimetabolan species, Locusta migratoria and Acyrthosiphon pisum, and of four holometabolan species, Apis mellifera, Tribolium castaneum, Bombyx mori and Drosophila melanogaster. Our analyses show that the variation of insect miRNAs is an artefact mainly resulting from poor sampling and inaccurate miRNA annotation, and that insects share a conserved microRNA toolkit of 65 families exhibiting very low variation. For example, the evolutionary shift toward a complete metamorphosis was accompanied only by the acquisition of three and the loss of one miRNA families. PMID:27883064

  2. T Pyxidis: Death by a Thousand Novae

    CERN Document Server

    Patterson, Joseph; Kemp, Jonathan; Monard, Berto; Rea, Robert; Hambsch, Franz-Josef; McCormick, Jennie; Nelson, Peter; Allen, William; Krajci, Thomas; Lowther, Simon; Dvorak, Shawn; Borgman, Jordan; Richards, Thomas; Myers, Gordon; Harlingten, Caisey; Bolt, Greg

    2016-01-01

    We report a 20-year campaign to track the 1.8 hour photometric wave in the recurrent nova T Pyxidis, using the global telescope network of the Center for Backyard Astrophysics. During 1996-2011, that wave was highly stable in amplitude and waveform, resembling the orbital wave commonly seen in supersoft binaries. The period, however, was found to increase on a timescale P/P-dot=3x10^5 years. This suggests a mass transfer rate in quiescence of ~10^-7 M_sol/yr, in substantial agreement with the accretion rate based on the star's luminosity. This is ~2000x greater than is typical for cataclysmic variables of that orbital period. During the post-eruption quiescence (2012-2016), the star continued on its merry but mysterious way - similar luminosity, similar P/P-dot (2.4x10^5 years). The orbital signal became vanishingly weak (300 years of accretion at the pre-outburst rate, but the time between outbursts was only 45 years. Thus the erupting white dwarf seems to have ejected at least 6x more mass than it accreted....

  3. On Heavy Element Enrichment in Classical Novae

    CERN Document Server

    Alexakis, A; Heger, A; Brown, E F; Dursi, L J; Truran, J W; Rosner, R; Lamb, D Q; Timmes, F X; Fryxell, B; Zingale, M A; Ricker, P M; Olson, K

    2004-01-01

    Many classical nova ejecta are enriched in CNO and Ne. Rosner et al. recently suggested that the enrichment might originate in the resonant interaction between large-scale shear flows in the accreted H/He envelope and gravity waves at the interface between the envelope and the underlying C/O white dwarf. The shear flow amplifies the waves, which eventually form cusps and break. This wave breaking injects a spray of C/O into the superincumbent H/He. Using two-dimensional simulations, we formulate a quantitative expression for the amount of C/O that can be entrained into the H/He at saturation. The fraction of the envelope that is enriched depends on the shear velocity and density contrast between the C/O white dwarf and the H/He layer but is roughly independent of the shape of the shear profile. Using this parameterization for the mixed mass, we then perform several one-dimensional Lagrangian calculations of an accreting white dwarf envelope and consider two scenarios: that the wave breaking and mixing is driv...

  4. T Pyxidis: death by a thousand novae

    Science.gov (United States)

    Patterson, Joseph; Oksanen, Arto; Kemp, Jonathan; Monard, Berto; Rea, Robert; Hambsch, Franz-Josef; McCormick, Jennie; Nelson, Peter; Allen, William; Krajci, Thomas; Lowther, Simon; Dvorak, Shawn; Borgman, Jordan; Richards, Thomas; Myers, Gordon; Harlingten, Caisey; Bolt, Greg

    2017-04-01

    We report a 20-yr campaign to track the 1.8 h photometric (and orbital) wave in the recurrent nova T Pyxidis. Before and after the 2011 eruption, the period increased on a time-scale P/dot{P} = 3 × 105 yr. This suggests a mass transfer rate in quiescence of ˜10-7 M⊙ yr-1, in substantial agreement with the accretion rate based on the star's luminosity. During the eruption itself, a rapid period increase of 0.0054(7) per cent occurred. This is probably a measure of the mass ejected in the outburst. For a plausible choice of binary parameters, that mass is at least 3 × 10-5 M⊙, and probably more. This represents >300 yr of accretion at the pre-outburst rate, but the time between outbursts was only 45 yr. Thus, the erupting white dwarf (WD) seems to have ejected at least six times more mass than it accreted. If this eruption is typical, the WD must be eroding, rather than growing, in mass. Unless the present series of eruptions is a short-lived episode, the binary dynamics will evaporate the secondary in ˜105 yr. This could be a major channel by which short-period cataclysmic variables are removed from the population.

  5. Carnaval da Nova Consciência

    Directory of Open Access Journals (Sweden)

    Elisete Schwade

    2011-06-01

    Full Text Available Neste artigo faço uma descrição etnográfica do "Encontro Para a Nova Consciência" - ENC, que acontece anualmente em Campina Grande-PB, no período do carnaval, desde 1992. Um evento que promove o contato inter-religioso, ao mesmo tempo em que divulga uma "leitura" de realidades com conotação terapêutica. Propõe o diálogo de práticas religiosas com temas de amplo interesse na atualidade, tais como tolerância, paz, diversidade, questões ambientais, entre outros. Um espaço aberto que incorpora a cada edição novos diálogos, o que contribui para sua permanência. O texto sublinha interações e diálogos entre atores no ENC, por meio de referências associadas à religiosidade, enquanto vivência e partilha, num horizonte de produção e difusão de práticas e conteúdos que ganham expressividade pelo reconhecimento coletivo.

  6. Dysregulated microRNAs in neurodegenerative disorders.

    Science.gov (United States)

    Lau, Pierre; de Strooper, Bart

    2010-09-01

    The complexity of the nervous system arises in part, from the large diversity of neural cell types that support the architecture of neuronal circuits. Recent studies have highlighted microRNAs as important players in regulating gene expression at the post-transcriptional level and therefore the phenotype of neural cells. A link between microRNAs and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease is becoming increasingly evident. Here, we discuss microRNAs in neurodegeneration, from the fruit fly and mouse utilized as experimental models to dysregulated microRNAs in human neurodegenerative disorders. We propose that studying microRNAs and their mRNA targets in the context of neurodegeneration will significantly contribute to the identification of proteins important for neuronal function and might reveal underlying molecular networks that drive these diseases.

  7. Dependent Classes

    DEFF Research Database (Denmark)

    Gasiunas, Vaidas; Mezini, Mira; Ostermann, Klaus

    2007-01-01

    Virtual classes allow nested classes to be refined in subclasses. In this way nested classes can be seen as dependent abstractions of the objects of the enclosing classes. Expressing dependency via nesting, however, has two limitations: Abstractions that depend on more than one object cannot...... be modeled and a class must know all classes that depend on its objects. This paper presents dependent classes, a generalization of virtual classes that expresses similar semantics by parameterization rather than by nesting. This increases expressivity of class variations as well as the flexibility...... of their modularization. Besides, dependent classes complement multi-methods in scenarios where multi-dispatched abstractions rather than multi-dispatched method are needed. They can also be used to express more precise signatures of multi-methods and even extend their dispatch semantics. We present a formal semantics...

  8. microRNA Decay: Refining microRNA Regulatory Activity.

    Science.gov (United States)

    Pepin, Genevieve; Gantier, Michael P

    2016-01-01

    MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.

  9. Outburst of the recurrent nova V745 Sco

    Science.gov (United States)

    Waagen, Elizabeth O.

    2014-02-01

    The outburst of the recurrent nova V745 Sco (Nova Sco 1937) by Rod Stubbings (Tetoora Road, VIC, Australia) at visual magnitude 9.0 on 2014 February 6.694 UT is reported. This recurrent nova is fading quickly. Follow-up observations of all types (visual, CCD, DSLR) are strongly encouraged, as is spectroscopy; fast time-series of this nova may be useful to detect possible flaring activity as was observed during the outburst of U Scorpii in 2010. Coincident time-series by multiple observers would be most useful for such a study, with a V-filter being preferred. Observations reported to the AAVSO International Database show V745 Sco at visual mag. 10.2 on 2014 Feb. 07.85833 UT (A. Pearce, Nedlands, W. Australia). Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. Previous outbursts occurred in 1937 and 1989. The 1937 outburst was detected in 1958 (in decline at magnitude 11.0 on 1937 May 11.1 UT; outburst had occurred within the previous 19 days) by Lukas Plaut on plates taken by Hendrik van Gent at the Leiden Observatory; the object was announced as Nova Sco 1937 and later assigned the GCVS name V745 Sco. The 1989 outburst was detected on 1989 August 1.55 UT by Mati Morel (MMAT, Thornton, NSW, Australia) at visual magnitude 10.4 and in decline. Dr. Bradley Schaefer (Louisiana State University) reports (2010ApJS..187..275S) in his comprehensive analysis of the 10 known galactic recurrent novae (including V745 Sco) that the median interval between recurrent novae outbursts is 24 years. The interval since the 1989 outburst of V745 Sco is 24.10 years. See the Alert Notice for additional visual and multicolor photometry and for more details.

  10. MAPEAMENTO DAS ÁREAS SUSCETÍVEIS À EROSÃO HÍDRICA NOS MUNICÍPIOS DE CALDAS NOVAS, NOVA AMÉRICA E RIO QUENTE (GO MAPPING THE EROSION SUSCEPTIBLE AREAS OF CALDAS NOVAS, NOVA AMÉRICA AND RIO QUENTE, GOIÁS - BRASIL

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Coutinho de Oliveira

    2007-09-01

    Full Text Available

    class="western" align="justify">A importância de mapear as áreas suscetíveis à erosão hídrica nos municípios de Caldas Novas, Nova América e Rio Quente deve-se ao fato de que eles apresentaram os maiores índices de precipitação pluviométrica e pelo potencial que os mesmos representam para o estado de Goiás, principalmente o turístico. Na elaboração desses mapas, estabeleceram-se preliminarmente os planos de informação referentes às classes de solo, à declividade e ao uso do solo através de digitalização, empregando o software SGI/INPE, e a espacialização da intensidade de precipitação com duração de 30 minutos sobre a base cartográfica dos municípios, obtendo assim os mapas temáticos. Através do cruzamento dos mapas temáticos, foram classificadas e mapeadas as áreas suscetíveis à erosão hídrica. A metodologia empregada mostrou-se satisfatória, permitindo gerar os mapas temáticos das áreas suscetíveis à erosão hídrica nos municípios estudados que servirão de orientação para os trabalhos de campo.

    class="western" align="justify">PALAVRAS-CHAVE: Erosão; sistema de informação geográfica; conservação do solo.

    class="western" align="justify">The importance of mapping the erosion susceptible areas of Caldas Novas, Nova América and Rio Quente is that these municipalities present high rainfall rates and the potential they represent for the Goiás state, mostly for tourism. As a preliminary to elaborate these maps the soil type, slope and use of classes information were planned through digitalization using the SGI/INPE software, and a spatialization of the 30 minutes rainfall intensity over the municipalities cartographic base, obtaining the thematic maps. Through thematic maps crossing, the erosion susceptible areas were classified and mapped. The methodology used was considered satisfactory and generated the thematic

  11. Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing

    Science.gov (United States)

    Background: MicroRNAs (miRNAs), a class of small non-coding endogenous RNAs that regulate gene expression post-transcriptionally, play multiple key roles in plant growth and development and in biotic and abiotic stress response. Knowledge and roles of miRNAs in pomegranate fruit development have not...

  12. Preliminary analysis of microRNA transcriptome altered by vaccine and Marek’s disease virus in chickens

    Science.gov (United States)

    MicroRNAs are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level and play important roles in many biological processes such as development, cell signaling and immune response. Mature miRNAs are about 22 nucleotides in length. Reportedly, the growth of v...

  13. Phenotypic MicroRNA Microarrays

    OpenAIRE

    2013-01-01

    Microarray technology has become a very popular approach in cases where multiple experiments need to be conducted repeatedly or done with a variety of samples. In our lab, we are applying our high density spots microarray approach to microscopy visualization of the effects of transiently introduced siRNA or cDNA on cellular morphology or phenotype. In this publication, we are discussing the possibility of using this micro-scale high throughput process to study the role of microRNAs in the bio...

  14. Terra Nova Environmental effects monitoring program

    Energy Technology Data Exchange (ETDEWEB)

    Williams, U. [Petro-Canada Inc., St. John' s, NF (Canada); Murdoch, M. [Jacques Whitford Environmental Limited (Canada)

    2000-07-01

    Elements of the environmental effects monitoring program in the Terra Nova oil field, about 350 km east-southeast of St. John's, Newfoundland, are described. This oilfield is being developed using a floating production storage and offloading (FPSO) facility. A total of 24 wells are expected to be drilled through seven subsea templates located in four glory holes to protect them from icebergs. Subsea installations will be linked to the FPSO by trenched flowlines connected to flexible risers. The FPSO will offload to shuttle tankers. First oil is expected in 2001. The environmental effects monitoring program will be conducted annually for the first two years beginning in 2000. Subsequent scheduling will be determined after a review of monitoring data collected during the first three years. Input to the design of the monitoring program was provided by all stakeholders, i. e. owners, local public, government agencies and regional and international experts. A model was developed linking project discharges and possible effects to the environment, including marine resources in the area, and the information derived from these activities was used to generate a set of predictions and hypotheses to be tested in the monitoring program. The monitoring program will use two spatial models: a regression or gradient design and a control-impact design. The gradient design will monitor water column and sediment chemistry, sediment toxicity and benthic invertebrate communities. The control-impact design will be used to monitor larger and more mobile fish or shellfish. The evaluated results will serve as the basis for determining impact predictions and to provide information to allow for decisions pertaining to the protection of the marine environment.

  15. Massive NLTE models for X-ray novae with PHOENIX

    CERN Document Server

    van Rossum, Daniel R

    2012-01-01

    X-ray grating spectra provide the confirmation of continued mass loss from novae in the super-soft source (SSS) phase of the outburst. In this work expanding nova atmosphere models are developed and used to study the effect of mass loss on the SSS spectra. The very high temperatures combined with high expansion velocities and large radial extension make nova in the SSS phase very interesting but also difficult objects to model. The radiation transport code PHOENIX was applied to SSS novae before, but careful analysis of the old results has revealed a number of problems which lead to new methods and improvements to the code: 1) an improved NLTE module (a new opacity formalism, rate matrix solver, global iteration scheme, and temperature correction method); 2) a new hybrid hydrostatic-dynamic nova atmosphere setup; 3) the models are treated in pure NLTE (no LTE approximation for any opacity). With the new framework a modest amount of models (limited by computation time) are calculated. These show: 1) systematic...

  16. π0 mass reconstruction in NOvA Far Detector.

    Science.gov (United States)

    Edayath, Sijith

    2017-01-01

    NOvA is a long-baseline neutrino oscillation experiment with functionally identical, segmented, tracking calorimeter Near and Far detectors. The detectors lie 14.6 mrad off-axis from the Fermilab NuMI beam, with a well-defined peak in neutrino energy at 2 GeV. The absolute calibration of the energy scale of the detectors is a major systematic uncertainty in long-baseline oscillation search in NOvA. Neutrino detectors make use of some standard candles for absolute energy calibration. Stopping muon energy distributions, Michel electron energy distributions, and invariant π0 mass are among them. In this talk, we cover NOvA's use of a new method to identify π0 with cosmic origins in the NOvA Far Detector. We employ a computer vision based particle identifier using convolutional neural networks (CVN) to identify π0s, complementing an existing strategy to identify π0 from the neutrino beam using more traditional methods in the Near Detector. Registered for PhD at Cochin University of Science and Technology, India and doing research in NOvA experiment at Fermilab.

  17. RZ Leonis Minoris Bridging between ER Ursae Majoris-Type Dwarf Nova and Novalike System

    CERN Document Server

    Kato, Taichi; Isogai, Keisuke; Kimura, Mariko; Imada, Akira; Miller, Ian; Masumoto, Kazunari; Nishino, Hirochika; Kojiguchi, Naoto; Kawabata, Miho; Sakai, Daisuke; Sugiura, Yuki; Furukawa, Hisami; Yamamura, Kenta; Kobayashi, Hiroshi; Matsumoto, Katsura; Wang, Shiang-Yu; Chou, Yi; Ngeow, Chow-Choong; Chen, Wen-Ping; Panwar, Neelam; Lin, Chi-Sheng; Hsiao, Hsiang-Yao; Guo, Jhen-Kuei; Lin, Chien-Cheng; Omarov, Chingis; Kusakin, Anatoly; Krugov, Maxim; Starkey, Donn R; Pavlenko, Elena P; Antonyuk, Kirill A; Sosnjvskij, Aleksei A; Antonyuk, Oksana I; Pit, Nikolai V; Baklanov, Alex V; Babina, Julia V; Itoh, Hiroshi; Padovan, Stefano; Akazawa, Hidehiko; Kafka, Stella; de Miguel, Enrique; Pickard, Roger D; Kiyota, Seiichiro; Shugarov, Sergey Yu; Chochol, Drahomir; Krushevska, Viktoriia; Sekeras, Matej; Pikalova, Olga; Sabo, Richard; Dubovsky, Pavol A; Kudzej, Igor; Ulowetz, Joseph; Dvorak, Shawn; Stone, Geoff; Tordai, Tamas; Dubois, Franky; Logie, Ludwig; Rau, Steve; Vanaverbeke, Siegfried; Vanmunster, Tonny; Oksanen, Arto; Maeda, Yutaka; Kasai, Kiyoshi; Katysheva, Natalia; Morelle, Etienne; Neustroev, Vitaly V; Sjoberg, George

    2016-01-01

    We observed RZ LMi, which is renowned for the extremely (~19d) short supercycle and is a member of a small, unusual class of cataclysmic variables called ER UMa-type dwarf novae, in 2013 and 2016. In 2016, the supercycles of this object substantially lengthened in comparison to the previous measurements to 35, 32, 60d for three consecutive superoutbursts. We consider that the object virtually experienced a transition to the novalike state (permanent superhumper). This observed behavior extremely well reproduced the prediction of the thermal-tidal instability model. We detected a precursor in the 2016 superoutburst and detected growing (stage A) superhumps with a mean period of 0.0602(1)d in 2016 and in 2013. Combined with the period of superhumps immediately after the superoutburst, the mass ratio is not as small as in WZ Sge-type dwarf novae, having orbital periods similar to RZ LMi. By using least absolute shrinkage and selection operator (Lasso) two-dimensional power spectra, we detected possible negative ...

  18. Birthing Classes

    Science.gov (United States)

    ... first birth and hope to have a vaginal delivery this time, there is a class for that, too. Choose ... t covered in your birthing class, it’s a good idea to take an individual class on it, especially if you are a first-time mother. The health benefits of breastfeeding your baby ...

  19. The MicroRNA Pathway and Fragile X Mental Retardation Protein

    OpenAIRE

    Li, Yujing; Lin, Li; Jin, Peng

    2008-01-01

    Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). MicroRNAs (miRNAs), a newly discovered class of small noncoding RNAs, have been implicated in multiple biological processes through posttranscriptional gene regulation. Recent evidence supports this view in terms of the biochemical and genetic interaction found between FMRP and the miRNA pathway, providing deeper insight into the mo...

  20. The Star of Bethlehem is Not the Nova DO Aquilae (Nor Any Other Nova, Supernova, or Comet)

    CERN Document Server

    Schaefer, Bradley E

    2013-01-01

    The Star of Bethlehem is only known from a few verses in the Gospel of Matthew, with the Star inspiring and leading the Magi (i.e., Persian astrologers) to Jerusalem and ultimately worshipping the young Jesus Christ in Bethlehem. In the last four centuries, astronomers have put forth over a dozen greatly different naturalistic explanations, all involving astronomical events, often a bright nova, supernova, or comet. This paper will evaluate one prominent recent proposal, that the Star was a 'recurrent nova' now catalogued as DO Aquilae, and provide three refutations. In particular, (1) DO Aql is certainly not a recurrent nova, but rather an ordinary nova with a recurrence time scale of over a million years, (2) in its 1925 eruption, DO Aql certainly never got brighter than 8.5 mag, and the physics of the system proves that it could never get to the required luminosity of a supernova, and (3) the Magi were astrologers who had no recognition or interpretation for novae (or supernovae or comets) so any such even...

  1. Very-high-energy {\\gamma}-ray observations of novae and dwarf novae with the MAGIC telescopes

    CERN Document Server

    Ahnen, M L; Antonelli, L A; Antoranz, P; Babic, A; Banerjee, B; Bangale, P; de Almeida, U Barres; Barrio, J A; González, J Becerra; Bednarek, W; Bernardini, E; Biasuzzi, B; Biland, A; Blanch, O; Bonnefoy, S; Bonnoli, G; Borracci, F; Bretz, T; Carmona, E; Carosi, A; Chatterjee, A; Clavero, R; Colin, P; Colombo, E; Contreras, J L; Cortina, J; Covino, S; Da Vela, P; Dazzi, F; De Angelis, A; De Caneva, G; De Lotto, B; Wilhelmi, E de Oña; Mendez, C Delgado; Di Pierro, F; Prester, D Dominis; Dorner, D; Doro, M; Einecke, S; Glawion, D Eisenacher; Elsaesser, D; Fernández-Barral, A; Fidalgo, D; Fonseca, M V; Font, L; Frantzen, K; Fruck, C; Galindo, D; López, R J García; Garczarczyk, M; Terrats, D Garrido; Gaug, M; Giammaria, P; Godinović, N; Muñoz, A González; Guberman, D; Hanabata, Y; Hayashida, M; Herrera, J; Hose, J; Hrupec, D; Hughes, G; Idec, W; Kellermann, H; Kodani, K; Konno, Y; Kubo, H; Kushida, J; La Barbera, A; Lelas, D; Lewandowska, N; Lindfors, E; Lombardi, S; Longo, F; López, M; López-Coto, R; López-Oramas, A; Lorenz, E; Majumdar, P; Makariev, M; Mallot, K; Maneva, G; Manganaro, M; Mannheim, K; Maraschi, L; Marcote, B; Mariotti, M; Martínez, M; Mazin, D; Menzel, U; Miranda, J M; Mirzoyan, R; Moralejo, A; Nakajima, D; Neustroev, V; Niedzwiecki, A; Rosillo, M Nievas; Nilsson, K; Nishijima, K; Noda, K; Orito, R; Overkemping, A; Paiano, S; Palacio, J; Palatiello, M; Paneque, D; Paoletti, R; Paredes, J M; Paredes-Fortuny, X; Persic, M; Poutanen, J; Moroni, P G Prada; Prandini, E; Puljak, I; Reinthal, R; Rhode, W; Ribó, M; Rico, J; Garcia, J Rodriguez; Saito, T; Saito, K; Satalecka, K; Scapin, V; Schultz, C; Schweizer, T; Sillanpää, A; Sitarek, J; Snidaric, I; Sobczynska, D; Stamerra, A; Steinbring, T; Strzys, M; Takalo, L; Takami, H; Tavecchio, F; Temnikov, P; Terzić, T; Tescaro, D; Teshima, M; Thaele, J; Torres, D F; Toyama, T; Treves, A; Verguilov, V; Vovk, I; Will, M; Zanin, R; Desiante, R; Hays, E

    2015-01-01

    Context. In the last five years the Fermi Large Area Telescope (LAT) instrument detected GeV {\\gamma}-ray emission from five novae. The GeV emission can be interpreted in terms of an inverse Compton process of electrons accelerated in a shock. In this case it is expected that protons in the same conditions can be accelerated to much higher energies. Consequently they may produce a second component in the {\\gamma}-ray spectrum at TeV energies. Aims. We aim to explore the very-high-energy domain to search for {\\gamma}-ray emission above 50 GeV and to shed light on the acceleration process of leptons and hadrons in nova explosions. Methods. We have performed observations with the MAGIC telescopes of the classical nova V339 Del shortly after the 2013 outburst, triggered by optical and subsequent GeV {\\gamma}-ray detec- tions. We also briefly report on VHE observations of the symbiotic nova YY Her and the dwarf nova ASASSN-13ax. We complement the TeV MAGIC observations with the analysis of con- temporaneous Fermi-...

  2. Ultrastructure of extrusomes in hypotrichous ciliate Pseudourostyla nova

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yao; WANG Zhengjun; ZHANG Jun; GU Fukang

    2011-01-01

    The ultrastructure of extrusomes of the hypotrichous ciliate Pseudourostyla nova was observed in scanning and transmission electron microscopy and enzyme-cytochemistry. The results show that the distribution, morphological characteristics, morphogenesis process, and extrusive process of the extrusomes in P. nova are different from the trichocysts in Paramecium, suggesting that the extrusomes of P. nova can respond to environmental stimuli, play an important role in the defense of this species, and cannot be regarded as "trichocysts". The results also suggest that the extrusomes might be originated from the Golgi apparatus and mature in the cytoplasm; after the extrusion of mature extrusomes, the residual substance might be reabsorbed and reused by the ciliate cell via food vacuoles, and take part in material recycling of the cell.

  3. First Neutrino Oscillation Results from the NOvA experiment

    Energy Technology Data Exchange (ETDEWEB)

    Sachdev, Kanika [Fermilab

    2016-11-29

    NOvA is a long-baseline neutrino oscillation experiment on the NuMI muon neutrino beam at Fermilab. It consists of two functionally identical, nearly fully-active liquid-scintillator tracking calorimeters. The Near Detector (ND) at Fermilab is used to study the neutrino beam spectrum and composition before oscillations occur. The Far Detector in northern Minnesota, 810 km away, observes the oscillated beam and is used to extract the oscillation parameters. NOvA is designed to observe oscillations in two channels: disappearance channel ( ν μ → ν μ ) and ν e appearance channel ( ν μ → ν e ). This paper reports the measurements of both these channels based on the first NOvA data taken from February 16, 2014 till May 15, 2015

  4. Liquid scintillator production for the NOvA experiment

    CERN Document Server

    Mufson, S; Bower, C; Coan, T; Cooper, J; Corwin, L; Karty, J; Mason, P; Pla-Dalmau, A; Proudfoot, M

    2015-01-01

    The NOvA collaboration blended and delivered 8.8 kt (2.72M gal) of liquid scintillator to its detectors as its active detector medium. The composition of the scintillator was developed to meet the requirements of the experiment. The scintillator was shipped to the NOvA near and far detectors using dedicated stainless steel tanker trailers. A rigorous set of quality control procedures were put in place to assure that the liquid scintillator was blended to satisfy the transparency, light yield, and conductivity requirements. The incoming components, the blended scintillator, and the scintillator in the transport tanker trailers were all qualified with these procedures, which ensured that the NOvA scintillator was high quality and met its performance requirements.

  5. Identification of microRNAs in the coral Stylophora pistillata.

    KAUST Repository

    Liew, Yi Jin

    2014-03-21

    Coral reefs are major contributors to marine biodiversity. However, they are in rapid decline due to global environmental changes such as rising sea surface temperatures, ocean acidification, and pollution. Genomic and transcriptomic analyses have broadened our understanding of coral biology, but a study of the microRNA (miRNA) repertoire of corals is missing. miRNAs constitute a class of small non-coding RNAs of ∼22 nt in size that play crucial roles in development, metabolism, and stress response in plants and animals alike. In this study, we examined the coral Stylophora pistillata for the presence of miRNAs and the corresponding core protein machinery required for their processing and function. Based on small RNA sequencing, we present evidence for 31 bona fide microRNAs, 5 of which (miR-100, miR-2022, miR-2023, miR-2030, and miR-2036) are conserved in other metazoans. Homologues of Argonaute, Piwi, Dicer, Drosha, Pasha, and HEN1 were identified in the transcriptome of S. pistillata based on strong sequence conservation with known RNAi proteins, with additional support derived from phylogenetic trees. Examination of putative miRNA gene targets indicates potential roles in development, metabolism, immunity, and biomineralisation for several of the microRNAs. Here, we present first evidence of a functional RNAi machinery and five conserved miRNAs in S. pistillata, implying that miRNAs play a role in organismal biology of scleractinian corals. Analysis of predicted miRNA target genes in S. pistillata suggests potential roles of miRNAs in symbiosis and coral calcification. Given the importance of miRNAs in regulating gene expression in other metazoans, further expression analyses of small non-coding RNAs in transcriptional studies of corals should be informative about miRNA-affected processes and pathways.

  6. Identification of microRNAs in the coral Stylophora pistillata.

    Directory of Open Access Journals (Sweden)

    Yi Jin Liew

    Full Text Available Coral reefs are major contributors to marine biodiversity. However, they are in rapid decline due to global environmental changes such as rising sea surface temperatures, ocean acidification, and pollution. Genomic and transcriptomic analyses have broadened our understanding of coral biology, but a study of the microRNA (miRNA repertoire of corals is missing. miRNAs constitute a class of small non-coding RNAs of ∼22 nt in size that play crucial roles in development, metabolism, and stress response in plants and animals alike. In this study, we examined the coral Stylophora pistillata for the presence of miRNAs and the corresponding core protein machinery required for their processing and function. Based on small RNA sequencing, we present evidence for 31 bona fide microRNAs, 5 of which (miR-100, miR-2022, miR-2023, miR-2030, and miR-2036 are conserved in other metazoans. Homologues of Argonaute, Piwi, Dicer, Drosha, Pasha, and HEN1 were identified in the transcriptome of S. pistillata based on strong sequence conservation with known RNAi proteins, with additional support derived from phylogenetic trees. Examination of putative miRNA gene targets indicates potential roles in development, metabolism, immunity, and biomineralisation for several of the microRNAs. Here, we present first evidence of a functional RNAi machinery and five conserved miRNAs in S. pistillata, implying that miRNAs play a role in organismal biology of scleractinian corals. Analysis of predicted miRNA target genes in S. pistillata suggests potential roles of miRNAs in symbiosis and coral calcification. Given the importance of miRNAs in regulating gene expression in other metazoans, further expression analyses of small non-coding RNAs in transcriptional studies of corals should be informative about miRNA-affected processes and pathways.

  7. Identification of microRNAs in the coral Stylophora pistillata.

    Science.gov (United States)

    Liew, Yi Jin; Aranda, Manuel; Carr, Adrian; Baumgarten, Sebastian; Zoccola, Didier; Tambutté, Sylvie; Allemand, Denis; Micklem, Gos; Voolstra, Christian R

    2014-01-01

    Coral reefs are major contributors to marine biodiversity. However, they are in rapid decline due to global environmental changes such as rising sea surface temperatures, ocean acidification, and pollution. Genomic and transcriptomic analyses have broadened our understanding of coral biology, but a study of the microRNA (miRNA) repertoire of corals is missing. miRNAs constitute a class of small non-coding RNAs of ∼22 nt in size that play crucial roles in development, metabolism, and stress response in plants and animals alike. In this study, we examined the coral Stylophora pistillata for the presence of miRNAs and the corresponding core protein machinery required for their processing and function. Based on small RNA sequencing, we present evidence for 31 bona fide microRNAs, 5 of which (miR-100, miR-2022, miR-2023, miR-2030, and miR-2036) are conserved in other metazoans. Homologues of Argonaute, Piwi, Dicer, Drosha, Pasha, and HEN1 were identified in the transcriptome of S. pistillata based on strong sequence conservation with known RNAi proteins, with additional support derived from phylogenetic trees. Examination of putative miRNA gene targets indicates potential roles in development, metabolism, immunity, and biomineralisation for several of the microRNAs. Here, we present first evidence of a functional RNAi machinery and five conserved miRNAs in S. pistillata, implying that miRNAs play a role in organismal biology of scleractinian corals. Analysis of predicted miRNA target genes in S. pistillata suggests potential roles of miRNAs in symbiosis and coral calcification. Given the importance of miRNAs in regulating gene expression in other metazoans, further expression analyses of small non-coding RNAs in transcriptional studies of corals should be informative about miRNA-affected processes and pathways.

  8. Novas drogas no tratamento da dispepsia funcional New drugs for the treatment of functional dyspepsia

    Directory of Open Access Journals (Sweden)

    Luiz Ernesto de Almeida TRONCON

    2001-09-01

    Full Text Available Racional — A dispepsia funcional caracteriza-se pela ocorrência de sintomas digestivos altos, na ausência de qualquer evidência de doença orgânica ou anormalidade estrutural. O tratamento farmacológico atual desta condição é feito empiricamente com agentes anti-secretores ou drogas pró-cinéticas. Objetivos - Rever os avanços recentes nos conhecimentos sobre os mecanismos responsáveis pelo aparecimento dos sintomas, bem como o desenvolvimento de novas drogas capazes de interferir nestes mecanismos, que abrem a perspectiva de tratamento farmacológico mais racional e efetivo da dispepsia funcional. Método - Revisão sistemática do trabalhos publicados em língua inglesa, nos últimos 10 anos. Resultados - Novas drogas que aumentam a propulsão gastroduodenal incluem: derivados benzamídicos análogos da cisaprida, antagonistas dos receptores A da colecistocinina, agonistas de receptores opióides e uma nova classe de agonistas da motilina, semelhantes à eritromicina. Drogas agonistas dos receptores serotoninérgicos do plexo mioentérico, como o sumatriptano e a buspirona, podem aumentar a capacidade de acomodação do bolo alimentar. Por fim, novas drogas, de grupos farmacológicos diversos, estão sendo avaliadas quanto a sua capacidade de reduzir ou modificar a percepção sensorial visceral. Inclui este grupo a octreotida, a loxiglumida, o ondansetron e seus análogos, a fedotozina e os anti-depressivos tricíclicos, em doses baixas. Conclusões - Ainda que as novas drogas apresentem alto potencial de aperfeiçoar o tratamento da dispepsia funcional, há a necessidade de ensaios controlados, com número adequado de pacientes, para se comprovar a eficácia desses medicamentos. Além disso, as dificuldades em determinar o mecanismo subjacente aos sintomas pode limitar o impacto positivo das novas drogas no tratamento da dispepsia funcional.Background — Functional dyspepsia is defined by upper gastrointestinal symptoms without

  9. A Decade of Progress in Understanding the Eruptions of Classical Novae

    Science.gov (United States)

    Shara, M. M.

    2014-12-01

    During the 11 years since the 2002 Sitges Nova conference, over 700 refereed papers dealing with classical novae have been published. Rather than spend 2.3 seconds reviewing each one, I've tried to focus on the main themes that have captured the interests of most researchers. I've also used, as examples, the most influential and cited papers in each subfield, though a decade from now some of my choices may seem dated, provincial, or flat-out wrong. The key topics that I address include theory and simulations of nova explosions; the recurrent novae; observations of ejecta; symbiotic novae; connections between novae and type Ia supernovae; connections between classical and dwarf novae; extragalactic novae; the maximum magnitude - rate of decline relationship; and a set of challenges and unanswered questions that I hope we will have made much progress on by the time we reassemble around 2024.

  10. The geographic accessibility of pharmacies in Nova Scotia

    Science.gov (United States)

    Heard, Deborah; Fisher, Judith; Douillard, Jay; Muzika, Greg; Sketris, Ingrid S.

    2013-01-01

    Introduction: Geographic proximity is an important component of access to primary care and the pharmaceutical services of community pharmacies. Variations in access to primary care have been found between rural and urban areas in Canadian and international jurisdictions. We studied access to community pharmacies in the province of Nova Scotia. Methods: We used information on the locations of 297 community pharmacies operating in Nova Scotia in June 2011. Population estimates at the census block level and network analysis were used to study the number of Nova Scotia residents living within 800 m (walking) and 2 km and 5 km (driving) distances of a pharmacy. We then simulated the impact of pharmacy closures on geographic access in urban and rural areas. Results: We found that 40.3% of Nova Scotia residents lived within walking distance of a pharmacy; 62.6% and 78.8% lived within 2 km and 5 km, respectively. Differences between urban and rural areas were pronounced: 99.2% of urban residents lived within 5 km of a pharmacy compared with 53.3% of rural residents. Simulated pharmacy closures had a greater impact on geographic access to community pharmacies in rural areas than urban areas. Conclusion: The majority of Nova Scotia residents lived within walking or short driving distance of at least 1 community pharmacy. While overall geographic access appears to be lower than in the province of Ontario, the difference appears to be largely driven by the higher proportion of rural dwellers in Nova Scotia. Further studies should examine how geographic proximity to pharmacies influences patients’ access to traditional and specialized pharmacy services, as well as health outcomes and adherence to therapy. Can Pharm J 2013;146:39-46. PMID:23795168

  11. X-ray Observations of Novae with Swift

    Science.gov (United States)

    Page, Kim

    2016-07-01

    The rapid response capabilities of the Swift satellite, together with the daily planning of its observing schedule, make it an ideal mission for following novae in the X-ray and UV bands, particularly during their early phases of rapid evolution. A number of both classical and recurrent novae have been extensively monitored by Swift throughout their super-soft phase and later decline. We report results from these observations, including the high-amplitude flux variation often see at the start of the super-soft emission, the differing relationships between the X-ray and UV variability, and the spectral evolution seen in the X-ray band.

  12. V445 Puppis, a first identified helium nova

    Directory of Open Access Journals (Sweden)

    Mariko Kato

    2004-01-01

    Full Text Available La explosi on de 2001 de V445 Puppis ha mostrado que se trata de un objeto unico que presenta ausencia de hidr ogeno, enriquecimiento de helio y carbono y una lenta ca da de la curva de luz con una amplitud peque~na. Hemos calculado curvas de luz te oricas de novas de helio para con rmar que V445 Pup es el primer ejemplo de una nova de helio. Del ajuste de la curva de luz podemos concluir que la enana blanca es muy masiva 1:33M .

  13. Nova in Ophiuchus - TCP J17394608-2457555

    Science.gov (United States)

    Waagen, Elizabeth O.

    2017-05-01

    AAVSO Alert Notice 576 announces the discovery of a galactic nova in Ophiuchus, TCP J17394608-2457555, by Koichi Itagaki (Yamagata, Japan) at unfiltered CCD magnitude 13.6 on 2017 May 08.7511 UT. Spectroscopy indicating that TCP J17394608-2457555 is an FeII nova (highly reddened) was obtained 2017 May 11.15 UT by S. C. Wiliams (Lancaster) and M. J. Darnley (LJMU) (ATel #10366). Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.

  14. Liquid scintillator production for the NOvA experiment

    Energy Technology Data Exchange (ETDEWEB)

    Mufson, S., E-mail: mufson@indiana.edu [Indiana University, Bloomington, IN 47405 (United States); Baugh, B.; Bower, C. [Indiana University, Bloomington, IN 47405 (United States); Coan, T.E. [Southern Methodist University, Dallas, TX 75275 (United States); Cooper, J. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Corwin, L. [South Dakota School of Mines and Technology, Rapid City, SD 57701 (United States); Karty, J.A. [Indiana University, Bloomington, IN 47405 (United States); Mason, P. [University of Tennessee, Knoxville, TN 37916 (United States); Messier, M.D. [Indiana University, Bloomington, IN 47405 (United States); Pla-Dalmau, A. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Proudfoot, M. [Renkert Oil, Morgantown, PA 19543 (United States)

    2015-11-01

    The NOvA collaboration blended and delivered 8.8 kt (2.72M gal) of liquid scintillator as the active detector medium to its near and far detectors. The composition of this scintillator was specifically developed to satisfy NOvA's performance requirements. A rigorous set of quality control procedures was put in place to verify that the incoming components and the blended scintillator met these requirements. The scintillator was blended commercially in Hammond, IN. The scintillator was shipped to the NOvA detectors using dedicated stainless steel tanker trailers cleaned to food grade.

  15. The unreasonable effectiveness of experiments in constraining nova nucleosynthesis

    Directory of Open Access Journals (Sweden)

    Parikh Anuj

    2014-01-01

    Full Text Available Classical nova explosions arise from thermonuclear ignition in the envelopes of accreting white dwarfs in close binary star systems. Detailed observations of novae have stimulated numerous studies in theoretical astrophysics and experimental nuclear physics. These phenomena are unusual in nuclear astrophysics because most of the thermonuclear reaction rates thought to be involved are constrained by experimental measurements. This situation allows for rather precise statements to be made about which measurements are still necessary to improve the nuclear physics input to astrophysical models. We briefly discuss desired measurements in these environments with an emphasis on recent experimental progress made to better determine key rates.

  16. Optical Spectroscopy of the Classical Novae V339 Del (2013) and V5668 Sgr (2015 No. 2)

    Science.gov (United States)

    Wagner, R. Mark; Woodward, Charles E.; Starrfield, Sumner; Ilyin, Ilya; Strassmeier, Klaus G.; Page, Kim; Osborne, Julian P.; Beardmore, Andrew P.

    2016-01-01

    We report the results of optical spectroscopy of the gamma-ray classical novae V339 Del (2013) and V5668 Sgr (PNV J18365700-2855420/Nova Sgr 2015 No. 2) supplemented by UV and X-ray observations obtained with Swift. Our spectra were obtained with the Steward Observatory Bok 2.3 m telescope (+B&C), the MDM 2.4 m Hiltner telescope (+OSMOS), the 6.5 m MMT (+BlueChannel), and the 2 x 8.4 m Large Binocular Telescope (+MODS1 and PEPSI) between 2013 August and 2015 September. The PEPSI spectra cover all or part of the 384-907 nm spectral region at a resolution of up to 270,000 (1 km/s). This is the highest resolution available on any 8-10 m class telescope. V339 Del was discovered on 2015 August 14.58 by Itagaki at V about 6.8. This nova reached a peak magnitude of about 4.3 making it one of the brightest novae of this century. Because of its exceptional brightness it has been observed at a variety of wavelengths and by a host of observatories both on the ground and in space. V5668 Sgr was discovered on 2015 March 15.634 by Seach at a magnitude of 6.0. It subsequently reached a maximum brightness of about 4.0 in late March. High resolution PEPSI spectra obtained in early April show dramatic variations in the multi-component P Cygni-type line profiles. V5668 Sgr was observed to form dust in June thereafter fading to about 13th magnitude. Our recent observations show that it has now evolved into the nebular phase. SS acknowledges partial support from NSF and NASA grants to ASU. CEW acknowledges support from NASA.

  17. Geostatistical modelling of arsenic in drinking water wells and related toenail arsenic concentrations across Nova Scotia, Canada.

    Science.gov (United States)

    Dummer, T J B; Yu, Z M; Nauta, L; Murimboh, J D; Parker, L

    2015-02-01

    Arsenic is a naturally occurring class 1 human carcinogen that is widespread in private drinking water wells throughout the province of Nova Scotia in Canada. In this paper we explore the spatial variation in toenail arsenic concentrations (arsenic body burden) in Nova Scotia. We describe the regional distribution of arsenic concentrations in private well water supplies in the province, and evaluate the geological and environmental features associated with higher levels of arsenic in well water. We develop geostatistical process models to predict high toenail arsenic concentrations and high well water arsenic concentrations, which have utility for studies where no direct measurements of arsenic body burden or arsenic exposure are available. 892 men and women who participated in the Atlantic Partnership for Tomorrow's Health Project provided both drinking water and toenail clipping samples. Information on socio-demographic, lifestyle and health factors was obtained with a set of standardized questionnaires. Anthropometric indices and arsenic concentrations in drinking water and toenails were measured. In addition, data on arsenic concentrations in 10,498 private wells were provided by the Nova Scotia Department of Environment. We utilised stepwise multivariable logistic regression modelling to develop separate statistical models to: a) predict high toenail arsenic concentrations (defined as toenail arsenic levels ≥0.12 μg g(-1)) and b) predict high well water arsenic concentrations (defined as well water arsenic levels ≥5.0 μg L(-1)). We found that the geological and environmental information that predicted well water arsenic concentrations can also be used to accurately predict toenail arsenic concentrations. We conclude that geological and environmental factors contributing to arsenic contamination in well water are the major contributing influences on arsenic body burden among Nova Scotia residents. Further studies are warranted to assess appropriate

  18. NovaNET User Manual for C-Router Instructors. Second Edition Revised.

    Science.gov (United States)

    Fortner, Monica B.; Davis, Dennis M.

    The NovaNET computer system is a mainframe system with a large network of users sharing the same computer. This manual is intended to teach instructors how to use the NovaNET system to deliver instruction to their students. The manual is divided into four main sections, each of which teaches a group of skills needed by NovaNET instructors. The…

  19. NovaNET User Manual for C-Router Instructors. Second Edition Revised.

    Science.gov (United States)

    Fortner, Monica B.; Davis, Dennis M.

    The NovaNET computer system is a mainframe system with a large network of users sharing the same computer. This manual is intended to teach instructors how to use the NovaNET system to deliver instruction to their students. The manual is divided into four main sections, each of which teaches a group of skills needed by NovaNET instructors. The…

  20. Swift X-Ray Observations of Classical Novae. II. The Super Soft Source sample

    CERN Document Server

    Schwarz, Greg J; Osborne, J P; Page, K L; Evans, P A; Beardmore, A P; Walter, Frederick M; Helton, L Andrew; Woodward, Charles E; Bode, Mike; Starrfield, Sumner; Drake, Jeremy J

    2011-01-01

    The Swift GRB satellite is an excellent facility for studying novae. Its rapid response time and sensitive X-ray detector provides an unparalleled opportunity to investigate the previously poorly sampled evolution of novae in the X-ray regime. This paper presents Swift observations of 52 Galactic/Magellanic Cloud novae. We included the XRT (0.3-10 keV) X-ray instrument count rates and the UVOT (1700-8000 Angstroms) filter photometry. Also included in the analysis are the publicly available pointed observations of 10 additional novae the X-ray archives. This is the largest X-ray sample of Galactic/Magellanic Cloud novae yet assembled and consists of 26 novae with super soft X-ray emission, 19 from Swift observations. The data set shows that the faster novae have an early hard X-ray phase that is usually missing in slower novae. The Super Soft X-ray phase occurs earlier and does not last as long in fast novae compared to slower novae. All the Swift novae with sufficient observations show that novae are highly v...

  1. HUVEC respond to radiation by inducing the expression of pro-angiogenic microRNAs.

    Science.gov (United States)

    Vincenti, Sara; Brillante, Nadia; Lanza, Vincenzo; Bozzoni, Irene; Presutti, Carlo; Chiani, Francesco; Etna, Marilena Paola; Negri, Rodolfo

    2011-05-01

    MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by targeting mRNAs and triggering either repression of translation or RNA degradation. They have been shown to be involved in a variety of biological processes such as development, differentiation and cell cycle control, but little is known about their involvement in the response to irradiation. We showed here that in human umbilical vein endothelial cells (HUVEC) some miRNAs previously shown to have a crucial role in vascular biology are transiently modulated in response to a clinically relevant dose of ionizing radiation. In particular we identified an early transcriptional induction of several members of the microRNA cluster 17-92 and other microRNAs already known to be related to angiogenesis. At the same time we observed a peculiar behavior of the miR-221/222 cluster, suggesting an important role of these microRNAs in HUVEC homeostasis. We observed an increased efficiency in the formation of capillary-like structures in irradiated HUVEC. These results could lead to a new interpretation of the effect of ionizing radiation on endothelial cells and on the response of tumor endothelial bed cells to radiotherapy.

  2. A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

    Energy Technology Data Exchange (ETDEWEB)

    Powell, Joshua D.; Chen, Qiang; Mason, Hugh S.

    2016-08-01

    Abstract Key message nta-miR-398 is significantly up-regulated while nta-miR-428d is significantly down-regulated in tobacco after agroinfiltration AbstractMicroRNAs are a class of non-coding regulatory RNAs that can modulate development as well as alter innate antiviral defenses in plants. In this study we explored host changes at the microRNA level within tobacco (Nicotiana benthamiana) after expression of a recombinant anti-Ebola GP1 antibody through Agrobacterium tumefaciens agroinfiltration delivery. A multiplex nanoparticle-based cytometry assay tracked the host expression changes of 53 tobacco microRNAs. Our results revealed that the most abundant microRNAs in actively growing leaves corresponded to nanoparticle probes specific to nta-mir-6149 and nta-miR-168b. After agroinfiltration, probes targeting nta-mir-398 and nta-mir-482d were significantly altered in their respective expression levels and were further verified through RT-qPCR analysis. To our knowledge this study is the first to profile microRNA expression in tobacco after agroinfiltration using a multiplex nanoparticle approach.

  3. Micro-RNA - A potential for forensic science?

    Science.gov (United States)

    Courts, Cornelius; Madea, Burkhard

    2010-12-15

    Micro-RNAs (miRNAs) are a class of small non-coding RNA (ncRNA) molecules with a length of 18 to 24 nucleotides which play an essential regulative role for many cellular processes. Whereas mRNA-analysis has become a well established technique in many forensic laboratories, micro-RNA has only recently been introduced to forensic science. Herein we provide a short outline of biogenesis, mode of function and regulation of miRNAs and take a look at tissue and cell specific miRNA expression. After recapitulating the role of mRNA analysis in forensic science we compare it to miRNA analysis and discuss the results of two recent studies applying miRNA analysis to a forensic research setting. We conclude that analysis of miRNA and perhaps small non-coding RNAs in general clearly has potential for forensic applications and merits attention of forensic scientists. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  4. Plastic ingestion by fulmars and shearwaters at Sable Island, Nova Scotia, Canada.

    Science.gov (United States)

    Bond, Alexander L; Provencher, Jennifer F; Daoust, Pierre-Yves; Lucas, Zoe N

    2014-10-15

    Plastic pollution is widespread in the marine environment, and plastic ingestion by seabirds is now widely reported for dozens of species. Beached Northern Fulmars, Great Shearwaters, Sooty Shearwaters and Cory's Shearwaters are found on Sable Island, Nova Scotia, Canada regularly, and they can be used to assess plastic pollution. All species except Cory's Shearwaters contained plastic debris in their gastrointestinal tracts. Northern Fulmars, Sooty Shearwaters and Great Shearwaters all showed high prevalence of plastic ingestion (>72%), with Northern Fulmars having the highest number and mass of plastics among the species examined. There was no difference in plastic ingestion between sexes or age classes. In all species user plastics made up the majority of the pieces found, with industrial pellets representing only a small proportion in the samples. Sable Island could be an important monitoring site for plastic pollution in Atlantic Canada.

  5. Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer.

    Science.gov (United States)

    Halvorsen, Ann Rita; Helland, Åslaug; Gromov, Pavel; Wielenga, Vera Timmermans; Talman, Maj-Lis Møller; Brunner, Nils; Sandhu, Vandana; Børresen-Dale, Anne-Lise; Gromova, Irina; Haakensen, Vilde D

    2017-02-01

    It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cross-talk that exists among cells in a tumor microenvironment. Matched tumor interstitial fluid samples (TIF, n = 60), normal interstitial fluid samples (NIF, n = 51), corresponding tumor tissue specimens (n = 54), and serum samples (n = 27) were collected from patients with breast cancer, and detectable microRNAs were analyzed and compared. In addition, serum data from 32 patients with breast cancer and 22 healthy controls were obtained for a validation study. To identify potential serum biomarkers of breast cancer, first the microRNA profiles of TIF and NIF samples were compared. A total of 266 microRNAs were present at higher level in the TIF samples as compared to normal counterparts. Sixty-one of these microRNAs were present in > 75% of the serum samples and were subsequently tested in a validation set. Seven of the 61 microRNAs were associated with poor survival, while 23 were associated with the presence of immune cells and adipocytes. To our knowledge, these data demonstrate for the first time that profiling of microRNAs in TIF can identify novel biomarkers for the prognostic classification and detection of breast cancer. In addition, the present findings demonstrate that microRNAs may represent the cross-talk that occurs between tumor cells and their surrounding stroma. © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

  6. MicroRNA Regulation in Renal Pathophysiology

    Directory of Open Access Journals (Sweden)

    Jianghui Hou

    2013-06-01

    Full Text Available MicroRNAs are small, noncoding RNA molecules that regulate a considerable amount of human genes on the post-transcriptional level, and participate in many key biological processes. MicroRNA deregulation has been found associated with major kidney diseases. Here, we summarize current knowledge on the role of microRNAs in renal glomerular and tubular pathologies, with emphasis on the mesangial cell and podocyte dysfunction in diabetic nephropathy, the proximal tubular cell survival in acute kidney injury, the transport function of the thick ascending limb in Ca++ imbalance diseases, and the regulation of salt, K+ and blood pressure in the distal tubules. Identification of microRNAs and their target genes provides novel therapeutic candidates for treating these diseases. Manipulation of microRNA function with its sense or antisense oligonucleotide enables coordinated regulation of the entire downstream gene network, which has effectively ameliorated several renal disease phenotypes. The therapeutic potentials of microRNA based treatments, though promising, are confounded by major safety issues related to its target specificity, which remain to be fully elucidated.

  7. A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions

    Science.gov (United States)

    Creighton, Chad J.; Nagaraja, Ankur K.; Hanash, Samir M.; Matzuk, Martin M.; Gunaratne, Preethi H.

    2008-01-01

    MicroRNAs are short (∼22 nucleotides) noncoding RNAs that regulate the stability and translation of mRNA targets. A number of computational algorithms have been developed to help predict which microRNAs are likely to regulate which genes. Gene expression profiling of biological systems where microRNAs might be active can yield hundreds of differentially expressed genes. The commonly used public microRNA target prediction databases facilitate gene-by-gene searches. However, integration of microRNA–mRNA target predictions with gene expression data on a large scale using these databases is currently cumbersome and time consuming for many researchers. We have developed a desktop software application which, for a given target prediction database, retrieves all microRNA:mRNA functional pairs represented by an experimentally derived set of genes. Furthermore, for each microRNA, the software computes an enrichment statistic for overrepresentation of predicted targets within the gene set, which could help to implicate roles for specific microRNAs and microRNA-regulated genes in the system under study. Currently, the software supports searching of results from PicTar, TargetScan, and miRanda algorithms. In addition, the software can accept any user-defined set of gene-to-class associations for searching, which can include the results of other target prediction algorithms, as well as gene annotation or gene-to-pathway associations. A search (using our software) of genes transcriptionally regulated in vitro by estrogen in breast cancer uncovered numerous targeting associations for specific microRNAs—above what could be observed in randomly generated gene lists—suggesting a role for microRNAs in mediating the estrogen response. The software and Excel VBA source code are freely available at http://sigterms.sourceforge.net. PMID:18812437

  8. A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions.

    Science.gov (United States)

    Creighton, Chad J; Nagaraja, Ankur K; Hanash, Samir M; Matzuk, Martin M; Gunaratne, Preethi H

    2008-11-01

    MicroRNAs are short (approximately 22 nucleotides) noncoding RNAs that regulate the stability and translation of mRNA targets. A number of computational algorithms have been developed to help predict which microRNAs are likely to regulate which genes. Gene expression profiling of biological systems where microRNAs might be active can yield hundreds of differentially expressed genes. The commonly used public microRNA target prediction databases facilitate gene-by-gene searches. However, integration of microRNA-mRNA target predictions with gene expression data on a large scale using these databases is currently cumbersome and time consuming for many researchers. We have developed a desktop software application which, for a given target prediction database, retrieves all microRNA:mRNA functional pairs represented by an experimentally derived set of genes. Furthermore, for each microRNA, the software computes an enrichment statistic for overrepresentation of predicted targets within the gene set, which could help to implicate roles for specific microRNAs and microRNA-regulated genes in the system under study. Currently, the software supports searching of results from PicTar, TargetScan, and miRanda algorithms. In addition, the software can accept any user-defined set of gene-to-class associations for searching, which can include the results of other target prediction algorithms, as well as gene annotation or gene-to-pathway associations. A search (using our software) of genes transcriptionally regulated in vitro by estrogen in breast cancer uncovered numerous targeting associations for specific microRNAs-above what could be observed in randomly generated gene lists-suggesting a role for microRNAs in mediating the estrogen response. The software and Excel VBA source code are freely available at http://sigterms.sourceforge.net.

  9. MicroRNAs in neurodegeneration.

    Science.gov (United States)

    Bushati, Natascha; Cohen, Stephen M

    2008-06-01

    microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal survival, and potentially also in plasticity and learning. The absence of miRNAs in a variety of specific postmitotic neurons can lead to progressive loss of these neurons and behavioral defects reminiscent of the phenotypes seen in the pathologies of neurodegenerative diseases. Here, we review recent studies which provide a link between miRNA function and neurodegeneration. We also discuss evidence which might suggest involvement of miRNAs in the emergence or progression of neurodegenerative diseases.

  10. Dique seco de carena. Génova

    Directory of Open Access Journals (Sweden)

    Gai, Luigi

    1965-02-01

    Full Text Available After elaborate planning, the building, towing and sinking of the ship repairing dry dock at Genoa has now been completed. The dock is 260x52x21.5 m in size. Its structure is cellular and it is made of reinforced and prestressed concrete. A special feature of this dock is that it rests on a flexible bed of sand, dredged from the sea bed. To prepare this, the following operations were carried out: mud was first dredged away, the stony outcrops were levelled off, the spaces in between the rocks were filled with concrete, then the layer of sand was placed, and finally a surface of larger aggregate was prepared on top. The method of attaching the dock to the sea bed to ensure its stability is also noteworthy. After much thought, it was decided that once the dock was sunk at its final emplacement, if its cellular compartments were filled with sand ballast, its own weight would ensure its permanent stability in the face of rough seas. The maneuvers for floating the dock, and sinking it, were also complex, since it was essential to take carefully into account the state of the weather. Any storm might have severely damaged the dock's cellular structure. The prefabrication of the caissons, the jointing of them into a large structure, the construction of enclosing walls, the provision of galleries, companionways, and housing facilities inside the dock, and the towing, sinking and ballasting of this large and heavy structure, constitute a series of building and navigational operations of great complexity, which have tested the ability of the firm Fincosit, who specialise in hydraulic projects.Después de profundos estudios se ha terminado recientemente la construcción, remolque y hundimiento del dique seco de carena del puerto de Génova, cuyas dimensiones son: 260x52x21,5 metros. Es de estructura celular, y de hormigón armado y pretensado. La particularidad de la obra estriba en el apoyo de la plataforma sobre un lecho flexible de arena dragada del mar

  11. Development of the Hα profile in Nova Del 2013

    Science.gov (United States)

    Storrs, Alex; Mahmoudian, T.

    2014-01-01

    We report observations of the Hα profile of Nova Del 2013, with resolving power R = 3000. Starting in late August the expected P Cygni profile (blueshifted absorption) was observed. Beginning in September a redshifted absorption appears and strengthens through the month. We will report observations through fall and discuss possible causes of these features.

  12. 3D Hydrodynamic Simulation of Classical Novae Explosions

    Science.gov (United States)

    Kendrick, Coleman J.

    2015-01-01

    This project investigates the formation and lifecycle of classical novae and determines how parameters such as: white dwarf mass, star mass and separation affect the evolution of the rotating binary system. These parameters affect the accretion rate, frequency of the nova explosions and light curves. Each particle in the simulation represents a volume of hydrogen gas and are initialized randomly in the outer shell of the companion star. The forces on each particle include: gravity, centrifugal, coriolis, friction, and Langevin. The friction and Langevin forces are used to model the viscosity and internal pressure of the gas. A velocity Verlet method with a one second time step is used to compute velocities and positions of the particles. A new particle recycling method was developed which was critical for computing an accurate and stable accretion rate and keeping the particle count reasonable. I used C++ and OpenCL to create my simulations and ran them on two Nvidia GTX580s. My simulations used up to 1 million particles and required up to 10 hours to complete. My simulation results for novae U Scorpii and DD Circinus are consistent with professional hydrodynamic simulations and observed experimental data (light curves and outburst frequencies). When the white dwarf mass is increased, the time between explosions decreases dramatically. My model was used to make the first prediction for the next outburst of nova DD Circinus. My simulations also show that the companion star blocks the expanding gas shell leading to an asymmetrical expanding shell.

  13. Sorveglianza sistematica dell'ex-nova GK Persei.

    Science.gov (United States)

    Dalmeri, I.; Favero, G.; Milani, G. A.; Tonello, A.; Monella, R.

    The 1983 and 1986 optical outbursts of the old-nova GK Per (1901) obeyed to the rule of quasi-periodicity proposed by Sabbadin and Bianchini. During the outbursts the colour indexes (U-B), (B-V) and (V-R) showed a behaviour opposite to the luminosity of the star.

  14. Optical spectroscopy of the dwarf nova U Geminorum

    NARCIS (Netherlands)

    Unda-Sanzana, E.; Marsh, T.R.; Morales-Rueda, L.

    2006-01-01

    The dwarf nova U Gem is unique in having a direct measurement of the K velocity of its white dwarf from Hubble Space Telescope (HST) spectra (K1 = 107 +/- 2kms-1 from Long et al.). We present high-resolution optical spectra of U Gem in quiescence taken to test the accuracy to w

  15. The Formation of Cataclysmic Variables: The Influence of Nova Eruptions

    Science.gov (United States)

    Nelemans, G.; Siess, L.; Repetto, S.; Toonen, S.; Phinney, E. S.

    2016-01-01

    The theoretical and observed populations of pre-cataclysmic variables are dominated by systems with low-mass white dwarfs (WDs), while the WD masses in cataclysmic variables (CVs) are typically high. In addition, the space density of CVs is found to be significantly lower than in the theoretical models. We investigate the influence of nova outbursts on the formation and initial evolution of CVs. In particular, we calculate the stability of the mass transfer in the case where all of the material accreted on the WD is lost in classical novae and part of the energy to eject the material comes from a common-envelope-like interaction with the companion. In addition, we study the effect of an asymmetry in the mass ejection that may lead to small eccentricities in the orbit. We find that a common-envelope-like ejection significantly decreases the stability of the mass transfer, particularly for low-mass WDs. Similarly, the influence of asymmetric mass loss can be important for short-period systems and even more so for low-mass WDs; however, this influence likely disappears long before the next nova outburst due to orbital circularization. In both cases the mass-transfer rates increase, which may lead to observable (and perhaps already observed) consequences for systems that do survive to become CVs. However, a more detailed investigation of the interaction between nova ejecta and the companion and the evolution of slightly eccentric CVs is needed before definite conclusions can be drawn.

  16. Parasites of red foxes in New Brunswick and Nova Scotia.

    Science.gov (United States)

    Smith, H J

    1978-07-01

    Sixty-one red foxes from New Brunswick and Nova Scotia were examined for helminths. Alaria americana, A. arisaemoides, A. mustelae, Cryptocotyle lingua, Echinostoma revolution and Metorchis conjunctus, Capillaria aerophila, Crenosoma vulpis, Toxocara canis, Uncinaria stenocephala and Taenia crassiceps were found. Approximately 67% of the foxes examined were clinically affected with Sarcoptes scabiei mange.

  17. The awakening of a classical nova from hibernation

    CERN Document Server

    Mroz, P; Pietrukowicz, P; Szymanski, M K; Soszynski, I; Wyrzykowski, L; Poleski, R; Kozlowski, S; Skowron, J; Ulaczyk, K; Skowron, D; Pawlak, M

    2016-01-01

    Cataclysmic variable stars (CVs) are close binary systems consisting of a white dwarf (primary) that is accreting matter from a low-mass companion star (secondary). From time to time such systems undergo large-amplitude brightenings. The most spectacular eruptions, over $10^4$ times in brightness, occur in classical novae and are caused by a thermonuclear runaway on the surface of the white dwarf. Such eruptions are thought to recur on timescales of $10^4-10^6$. In between, the system's properties depend primarily on the mass-transfer rate: if it is lower than a $10^{-9} M_{\\odot}$/year, the accretion becomes unstable and the matter is dumped onto the white dwarf during quasi-periodic dwarf nova outbursts. The hibernation hypothesis predicts that nova eruptions strongly affect the mass-transfer rate, keeping it high for centuries after the event. Subsequently, the mass-transfer rate should significantly decrease for $10^3-10^6$ years, starting the hibernation phase. After that the nova awakes again - with acc...

  18. Luminous Red Nova 2015 in the Galaxy M101

    CERN Document Server

    Goranskij, V P; Spiridonova, O I; Valeev, A F; Fatkhullin, T A; Moskvitin, A S; Vozyakova, O V; Cheryasov, D V; Safonov, B S; Zharova, A V; Hancock, T

    2016-01-01

    We present the results of the study of the red nova PSN J14021678+5426205 based on the observations carried out with the Russian 6-m telescope (BTA) along with other telescopes of SAO RAS and SAI MSU. To investigate the nova progenitor, we used the data from the Digital Sky Survey and amateur photos available on the internet. In the period between April 1993 and July 2014, the brightness of the progenitor gradually increased by 2.2 mag in the V band. At the peak of the first outburst in mid-November of 2014, the star reached an absolute visual magnitude of -12.75 mag but was discovered later, in February 2015, in a repeated outburst at the absolute magnitude of -11.65 mag. The amplitude of the outburst was minimum among the red novae, only 5.6 mag in the V band. The H alpha emission line and the continuum of a cool supergiant with a gradually decreasing surface temperature were observed in the spectra. Such process is typical for red novae, although the object under study showed extreme parameters: maximum lu...

  19. A Dwarf Nova in the Globular Cluster M13

    NARCIS (Netherlands)

    Servillat, M.; Webb, N.A.; Lewis, F.; Knigge, C.; van den Berg, M.C.; Dieball, A.; Grindlay, J.E.

    2011-01-01

    Dwarf novae (DNe) in globular clusters (GCs) seem to be rare with only 13 detections in the 157 known Galactic GCs. We report the identification of a new DN in M13, the 14th DN identified in a GC to date. Using the 2 m Faulkes Telescope North, we conducted a search for stars in M13 that show variabi

  20. Parnassiana nova : XVII. Kritische Revision der Gattung Parnassius (Fortsetzung 12)

    NARCIS (Netherlands)

    Eisner, C.

    1957-01-01

    Meine in Parnassiana Nova VIII wiedergegebene Beurteilung der spanischen apollo-subspecies muss ich aufgrund der grossen Serien davon, die ich aus Sammlung R. Oberthür erworben habe, und aufgrund des Gedankenaustausches mit Dr. W. Marten teilweise berichtigen. subsp. chrysophorus Fruhst., die

  1. TV review: Nova scienceNOW - Season 2, Episode 4

    CERN Document Server

    Lasser, Josh

    2007-01-01

    "Sitting down to watch the fourth episode of the second season of Nova ScienceNOW I'm mainly struck by one thought: why have they only put out four epidoses nearly nine months into their second season? The second story is all about CERN and the LHC. (2 pages)

  2. Parnassiana nova : XVII. Kritische Revision der Gattung Parnassius (Fortsetzung 12)

    NARCIS (Netherlands)

    Eisner, C.

    1957-01-01

    Meine in Parnassiana Nova VIII wiedergegebene Beurteilung der spanischen apollo-subspecies muss ich aufgrund der grossen Serien davon, die ich aus Sammlung R. Oberthür erworben habe, und aufgrund des Gedankenaustausches mit Dr. W. Marten teilweise berichtigen. subsp. chrysophorus Fruhst., die niedri

  3. Discovery of a Probable Nova in M81

    Science.gov (United States)

    Hornoch, K.; Vaduvescu, O.; Mocnik, T.

    2014-09-01

    We report the discovery of a probable nova in M81 on a co-added 1440-s narrow-band H-alpha CCD image taken with the 2.5-m Isaac Newton Telescope (INT) + WFC at La Palma under ~2.2" seeing on 2014 Sep.

  4. Hydrodynamic studies of oxygen, neon, and magnesium novae

    Science.gov (United States)

    Starrfield, Sumner; Sparks, W. M.; Truran, J. W.

    1987-01-01

    Results are presented from recent theoretical studies that have examined the properties of nova outbursts on ONeMg white dwarfs. These outbursts are much more violent and occur much more frequently than outbursts on CO white dwarfs. Hydrodynamic simulations of both kinds of outbursts are in excellent agreement with the observations.

  5. The Present Status of the Antigonish Movement in Nova Scotia.

    Science.gov (United States)

    Sowder, Ellie Mae

    A comprehensive case study is presented of the Antigonish Movement in eastern Nova Scotia. Originally founded to combat poverty and exploitation, it has functioned since 1929 under the extension department of St. Francis Xavier University, Antigonish. The Movement brought education into the lives of ordinary working people and introduced group…

  6. The Nova Upgrade Facility for ICF ignition and gain

    Science.gov (United States)

    Lowdermilk, W. H.; Campbell, E. M.; Hunt, J. T.; Murray, J. R.; Storm, E.; Tobin, M. T.; Trenholme, J. B.

    1992-01-01

    Research on Inertial Confinement Fusion (ICF) is motivated by its potential defense and civilian applications, including ultimately the generation of electric power. The U.S. ICF Program was reviewed recently by the National Academy of Science (NAS) and the Fusion Policy Advisory Committee (FPAC). Both committees issued final reports in 1991 which recommended that first priority in the ICF program be placed on demonstrating fusion ignition and modest gain (G less than 10). The U.S. Department of Energy and Lawrence Livermore National Laboratory (LLNL) have proposed an upgrade of the existing Nova Laser Facility at LLNL to accomplish these goals. Both the NAS and FPAC have endorsed the upgrade of Nova as the optimal path to achieving ignition and gain. Results from Nova Upgrade Experiments will be used to define requirements for driver and target technology both for future high-yield military applications, such as the Laboratory Microfusion Facility (LMF) proposed by the Department of Energy, and for high-gain energy applications leading to an ICF engineering test facility. The central role and modifications which Nova Upgrade would play in the national ICF strategy are described.

  7. Role of microRNAs on adipogenesis, chronic low-grade inflammation, and insulin resistance in obesity.

    Science.gov (United States)

    Cruz, Kyria Jayanne Clímaco; de Oliveira, Ana Raquel Soares; Morais, Jennifer Beatriz Silva; Severo, Juliana Soares; Marreiro PhD, Dilina do Nascimento

    2017-03-01

    The aim of this review was to convey updated information on the role of microRNAs in adipogenesis, chronic low-grade inflammation, and insulin resistance in obesity. Obesity is a chronic disease characterized by the presence of metabolic disorders (e.g., low-grade chronic inflammation), which contributes to the manifestation of insulin resistance. Diverse molecular mechanisms have been implicated in the development of these disorders, and microRNAs stand out as a contributing factor. They are a class of noncoding RNAs that regulate the expression of genes by inducing cleavage of mRNAs or via inhibition of protein translation. It is important to point out that obese individuals show alterations in the expression of microRNAs favoring manifestation of the metabolic disorders present in these patients, and these alterations may be reversed by the loss of weight. Therefore, microRNAs may be regarded as potential biomarkers of obesity-related disorders. Further studies on this topic may advance the understanding of the molecular basis of obesity, including the participation of microRNAs in the pathogenesis of this disease.

  8. Radiative shocks create environments for dust formation in classical novae

    Science.gov (United States)

    Derdzinski, Andrea M.; Metzger, Brian D.; Lazzati, Davide

    2017-08-01

    Classical novae commonly show evidence of rapid dust formation within months of the outburst. However, it is unclear how molecules and grains are able to condense within the ejecta, given the potentially harsh environment created by ionizing radiation from the white dwarf. Motivated by the evidence for powerful radiative shocks within nova outflows, we propose that dust formation occurs within the cool, dense shell behind these shocks. We incorporate a simple molecular chemistry network and classical nucleation theory with a model for the thermodynamic evolution of the post-shock gas, in order to demonstrate the formation of both carbon and forsterite (Mg2SiO4) grains. The high densities due to radiative shock compression (n ∼ 1014 cm-3) result in CO saturation and rapid dust nucleation. Grains grow efficiently to large sizes ≳ 0.1 μm, in agreement with IR observations of dust-producing novae, and with total dust masses sufficient to explain massive extinction events such as V705 Cas. As in dense stellar winds, dust formation is CO-regulated, with carbon-rich flows producing carbon-rich grains and oxygen-rich flows primarily forming silicates. CO is destroyed by non-thermal particles accelerated at the shock, allowing additional grain formation at late times, but the efficiency of this process appears to be low. Given observations showing that individual novae produce both carbonaceous and silicate grains, we concur with previous works attributing this bimodality to chemical heterogeneity of the ejecta. Nova outflows are diverse and inhomogeneous, and the observed variety of dust formation events can be reconciled by different abundances, the range of shock properties, and the observer viewing angle. The latter may govern the magnitude of extinction, with the deepest extinction events occurring for observers within the binary equatorial plane.

  9. Are presolar dust grains from novae actually from supernovae?

    Science.gov (United States)

    Nittler, L. R.; Hoppe, P.

    2005-05-01

    Meteorites contain presolar stardust grains that formed in prior generations of stars and exhibit large isotopic anomalies reflecting the nuclear processes that occurred in their individual parent stars. RGB and AGB stars and supernovae are well established as sources of many of these grains. Novae have been proposed as sources for a few SiC and graphite grains with low 12}C/{13C and 14}N/{15N ratios and unusual Si isotopic ratios (Amari et al., ApJ, 551, 1065). We have found three SiC grains from the Murchison meteorite with C and N isotopic ratios similar to the previously-reported putative nova grains. However, the isotopic signatures of Si, Ca, Al and Ti in one of the grains (334-2) clearly indicate a supernova origin, especially excess 28Si correlated with excess 44Ca. The latter signature is attributable to in situ decay of (half-life=50yr) 44Ti. Another 13C- and 15N-rich grain (151-4) has a large 47Ti enrichment. This signature is not expected for nova nucleosynthesis. Thus, the new isotopic data raise the possibility that the grains previously reported to have formed in novae actually formed in supernovae, and that novae have not left a record in the presolar grain populations that have been so far studied. Moreover, the results in grain 334-2 indicate that supernovae contain regions highly enriched in both 13C and 15N. This is not predicted by current models but may bear on the cosmic origin of 15N. This work was funded in part by NASA.

  10. MicroRNA: Biogenesis, Function and Role in Cancer

    OpenAIRE

    2010-01-01

    MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA. The conventional biogenesis pathway consists of two cleavage events, one nuclear and one cytoplasmic. However, alternative biogenesis pathways exist that differ in the number of cleavage events and enzymes responsible. How microRNA precursors...

  11. Expression profiling identifies microRNA signature in pancreatic cancer

    OpenAIRE

    Lee, Eun Joo; Gusev, Yuriy; Jiang, Jinmai; Gerard J Nuovo; Lerner, Megan R; Frankel, Wendy L.; Morgan, Daniel L.; Postier, Russell G.; Brackett, Daniel J; Schmittgen, Thomas D.

    2007-01-01

    microRNAs are functional, 22 nt, noncoding RNAs that negatively regulate gene expression. Disturbance of microRNA expression may play a role in the initiation and progression of certain diseases. A microRNA expression signature has been identified that is associated with pancreatic cancer. This has been accomplished with the application of real-time PCR profiling of over 200 microRNA precursors on specimens of human pancreatic adenocarcinoma, paired benign tissue, normal pancreas, chronic pan...

  12. Role of MicroRNA in Aggressive Prostate Cancer

    Science.gov (United States)

    2014-07-01

    AD_________________ Award Number: W81XWH-11-1-0491 TITLE: Role of MicroRNA in Aggressive Prostate... MicroRNA in Aggressive Prostate Cancer 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0491 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jer...action is not fully characterized. Using microRNA microarray screening, we found microRNA -363 (miR363) is significantly down regulated in several

  13. Implications of micro-RNA profiling for cancer diagnosis.

    Science.gov (United States)

    Cummins, J M; Velculescu, V E

    2006-10-09

    Micro-RNAs (miRNAs) are a large class of small non-coding RNAs that regulate protein expression in eucaryotic cells. Initially believed to be unique to the nematode Caenorhabditis elegans, miRNAs are now recognized to be important gene regulatory elements in multicellular organisms and have been implicated in a variety of disease processes, including cancer. Advances in expression technologies have facilitated the high-throughput analysis of small RNAs, identifying novel miRNAs and showing that these genes may be aberrantly expressed in various human tumors. These studies suggest that miRNA expression profiling can be correlated with disease pathogenesis and prognosis, and may ultimately be useful in the management of human cancer.

  14. Silencing human cancer: identification and uses of microRNAs.

    Science.gov (United States)

    Nicolas, Francisco E; Lopez-Gomollon, Sara; Lopez-Martinez, Alfonso F; Dalmay, Tamas

    2011-01-01

    MicroRNAs (miRNAs) are a new class of negative regulators that repress gene expression by pairing with their target messenger RNAs (mRNAs). There are hundreds of miRNAs coded in the human genome and thousands of target mRNAs participating in a wide variety of physiological processes such as development and cell identity. It is therefore not surprising that several recent reports involved deregulated miRNAs in the complex mechanism of human carcinogenesis, and proposed them as new key regulators to correct the unbalanced expression of oncogenes and tumour suppressor genes exhibited in cancer cells. This review summarises most of the recent patents related to the use of miRNA signatures in cancer diagnosis and prognosis, the detection and profiling of miRNAs from tumour samples and the identification of oncogenes and tumour suppressor genes targeted by miRNAs, as well as new cancer therapies based on miRNA modulators.

  15. The application of microRNAs in cancer diagnostics

    DEFF Research Database (Denmark)

    Sørensen, Karina Dalsgaard; Ostenfeld, Marie Stampe; Kristensen, Helle

    2012-01-01

    MicroRNAs (miRNAs) play important biological roles in cancer development and progression. During the past decade, widespread use of novel high-throughput technologies for miRNA profiling (e.g., microarrays and next-generation sequencing) has revealed deregulation of miRNA expression as a common...... hallmark of human cancer. Furthermore, miRNAs have been found to be a new class of promising cancer biomarkers with potential to improve the accuracy of diagnosis and prognosis in several hematologic and solid malignancies, as well as to predict response to specific treatments. Recent studies have...... identified exosome-associated tumor-derived miRNAs in, e.g., blood samples from cancer patients, suggesting that miRNAs may be useful as circulation biomarkers for noninvasive diagnostic testing. In this chapter, we review the current state of development of miRNAs as cancer biomarkers with examples from...

  16. Computational prediction of microRNA genes in silkworm genome

    Institute of Scientific and Technical Information of China (English)

    TONG Chuan-zhou; JIN Yong-feng; ZHANG Yao-zhou

    2006-01-01

    MicroRNAs (miRNAs) constitute a novel, extensive class of small RNAs (~21 nucleotides), and play important gene-regulation roles during growth and development in various organisms. Here we conducted a homology search to identify homologs of previously validated miRNAs from silkworm genome. We identified 24 potential miRNA genes, and gave each of them a name according to the common criteria. Interestingly, we found that a great number of newly identified miRNAs were conserved in silkworm and Drosophila, and family alignment revealed that miRNA families might possess single nucleotide polymorphisms. miRNA gene clusters and possible functions of complement miRNA pairs are discussed.

  17. MicroRNA therapeutics: principles, expectations, and challenges

    Institute of Scientific and Technical Information of China (English)

    Rajesha Rupaimoole; Hee-Dong Han; Gabriel Lopez-Berestein; Anil K. Sood

    2011-01-01

    MicroRNAs (miRNAs) are a class of highly abundant non-coding RNA molecules that are involved in several biological processes. Many miRNAs are often deregulated in several diseases including cancer. There is substantial interest in exploiting miRNAs for therapeutic applications. In this editorial, we briefly review current advances in the use of miRNAs or antisense oligonucleotides (antagomirs) for such therapies. One of the key issues related to therapy using miRNAs is degradation of naked particles in vivo. To overcome this limitation, delivery systems for miRNA-based therapeutic agents have been developed, which hold tremendous potential for improving therapeutic outcome of cancer patients.

  18. MicroRNAs: new players in the DNA damage response

    Institute of Scientific and Technical Information of China (English)

    Hailiang Hu; Richard A. Gatti

    2011-01-01

    The DNA damage response (DDR) is a signal transduction pathway that decides the cell's fate either to repair DNA damage or to undergo apoptosis if there is too much damage. Post-translational modifications modulate the assembly and activity of protein complexes during the DDR pathways. MicroRNAs (miRNAs) are emerging as a class of endogenous gene modulators that control protein levels, thereby adding a new layer of regulation to the DDR. In this review, we describe a new role for miRNAs in regulating the cellular response to DNA damage with a focus on DNA double-strand break damage. We also discuss the implications of miRNA's role in the DDR to stem cells, including embryonic stem cells and cancer stem cells, stressing the potential applications for miRNAs to be used as sensitizers for cancer radiotherapy and chemotherapy.

  19. Could MicroRNAs be Regulators of Gout Pathogenesis?

    Directory of Open Access Journals (Sweden)

    Yangang Wang

    2015-07-01

    Full Text Available MicroRNAs (miRNAs are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout.

  20. [Progress of research on microRNAs of parasites].

    Science.gov (United States)

    Zhou, Qing-Xin; Zhou, Yong-Hua; Zhang, Ying; Zhao, Zhong-Xi; Fan, Hong-Jie; Yao, Huo-Chun

    2013-04-01

    microRNAs (miRNAs) are small molecules of non-coding RNA, a class size of about 21-25 nt widespread in eukaryotes, resulting from single-stranded RNA precursors with the size of 70-90 bases of a hairpin structure generated after dicer enzyme processing. They play an important role in eukaryotic gene regulation, widely involved in cell proliferation, differentiation, development, metabolism, apoptosis and other physiological activities. miRNA extensively involved in the physiological and metabolic processes of the parasite development process, but the key miRNA relevant to parasite invasion of a host still lacks reports. This paper summarizes the miRNA analytical methods and the progress on its researches in parasitology.

  1. Plant microRNAs: master regulator of gene expression mechanism.

    Science.gov (United States)

    Datta, Riddhi; Paul, Soumitra

    2015-11-01

    Several signaling molecules critically regulate the physiological responses in plants. Among them, miRNAs, generally 21-24 nucleotides long, are widely distributed in different plant species and play as key signaling intermediates in diverse physiological responses. The mature miRNAs are synthesized from MIR genes by RNA polymerase II and processed by Dicer-like (DCL) protein family members associated with some accessory protein molecules. The processed miRNAs are transported to the cytoplasm from the nucleus by specific group of transporters and incorporated into RNA-induced silencing complex (RISC) for specific mRNA cleavage. MicroRNAs can suppress the diverse gene expression, depending on the sequence complementarity of the target transcript except of its own gene. Besides, miRNAs can modulate the gene expression by DNA methylation and translational inhibition of the target transcript. Different classes of DCLs and Argonaute proteins (AGOs) help the miRNAs-mediated gene silencing mechanism in plants.

  2. MicroRNAs and Type 2 Diabetes/Obesity

    Institute of Scientific and Technical Information of China (English)

    Mustafa Abdo Saif Dehwah; Aimin Xu; Qingyang Huang

    2012-01-01

    MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity.Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models.Emerging evidences suggest that miRNAs play significant roles in insulin production,secretion and actions,as well as in diverse aspects of glucose homeostasis and adipocyte differentiation.The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.

  3. MicroRNAs and type 2 diabetes/obesity.

    Science.gov (United States)

    Dehwah, Mustafa Abdo Saif; Xu, Aimin; Huang, Qingyang

    2012-01-01

    MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.

  4. Tallinna Ülikooli Balti Filmi- ja Meediakooli õppehoone Nova = Tallinn University Baltic Film and Media School "Nova"

    Index Scriptorium Estoniae

    2015-01-01

    Tallinna Ülikooli Balti Filmi- ja Meediakooli õppehoone "Nova" Narva maantee 27, valminud 2012. Arhitektuuri sihtkapitali arhitektuuripreemia 2012 ja Arhitektuuri sihtkapitali sisearhitektuuripreemia 2013. Arhitektid Maarja Kask, Karli Luik, Ralf Lõoke, Pelle-Sten Viiburg (Salto Arhitektid). Sisearhitektid Ville Lausmäe, Kadi Karmann (VLS). Mööbel Ville Lausmäe, Tõnis Kalve. Konstruktor Jaanus Natka (EA Reng)

  5. Tallinna Ülikooli Balti Filmi- ja Meediakooli õppehoone Nova = Tallinn University Baltic Film and Media School "Nova"

    Index Scriptorium Estoniae

    2015-01-01

    Tallinna Ülikooli Balti Filmi- ja Meediakooli õppehoone "Nova" Narva maantee 27, valminud 2012. Arhitektuuri sihtkapitali arhitektuuripreemia 2012 ja Arhitektuuri sihtkapitali sisearhitektuuripreemia 2013. Arhitektid Maarja Kask, Karli Luik, Ralf Lõoke, Pelle-Sten Viiburg (Salto Arhitektid). Sisearhitektid Ville Lausmäe, Kadi Karmann (VLS). Mööbel Ville Lausmäe, Tõnis Kalve. Konstruktor Jaanus Natka (EA Reng)

  6. The repertoire and features of human platelet microRNAs.

    Directory of Open Access Journals (Sweden)

    Hélène Plé

    Full Text Available Playing a central role in the maintenance of hemostasis as well as in thrombotic disorders, platelets contain a relatively diverse messenger RNA (mRNA transcriptome as well as functional mRNA-regulatory microRNAs, suggesting that platelet mRNAs may be regulated by microRNAs. Here, we elucidated the complete repertoire and features of human platelet microRNAs by high-throughput sequencing. More than 492 different mature microRNAs were detected in human platelets, whereas the list of known human microRNAs was expanded further by the discovery of 40 novel microRNA sequences. As in nucleated cells, platelet microRNAs bear signs of post-transcriptional modifications, mainly terminal adenylation and uridylation. In vitro enzymatic assays demonstrated the ability of human platelets to uridylate microRNAs, which correlated with the presence of the uridyltransferase enzyme TUT4. We also detected numerous microRNA isoforms (isomiRs resulting from imprecise Drosha and/or Dicer processing, in some cases more frequently than the reference microRNA sequence, including 5' shifted isomiRs with redirected mRNA targeting abilities. This study unveils the existence of a relatively diverse and complex microRNA repertoire in human platelets, and represents a mandatory step towards elucidating the intraplatelet and extraplatelet role, function and importance of platelet microRNAs.

  7. Em busca da nova pequena burguesia brasileira

    Directory of Open Access Journals (Sweden)

    Grün Roberto

    2000-01-01

    Full Text Available The article describes some new ways in which the Brazilian middle classes fit socially into the "world of neoliberalism". In recent years these layers of society have been prompted to believe that the traditional civil service job or, more recently, careers with large companies are no longer possible or desirable. These former pretensions have been replaced by the idea that franchising is the thing of the future. On the other side, the notion of "employability" has gained ground: through carefully thought-out career management and the accumulation of knowledge and skills, the agent can become "economically viable". In cognitive terms, the latter trend is the opposite of the former and gains stability through its negation. In analyzing the evidence, the author focuses on the historical antecedents and symbolic operations that work to lend the situation coherence. He also endeavors to identify connections with the economic sphere.

  8. Integrated analysis of microRNA and mRNA expression: Adding biological significance to microRNA target predictions

    NARCIS (Netherlands)

    M. van Iterson (Mat); S. Bervoets (Sander); E.J. de Meijer (Emile); H.P. Buermans (Henk); P.A.C. 't Hoen (Peter); R.X. Menezes (Renée); J.M. Boer (Judith)

    2013-01-01

    textabstractCurrent microRNA target predictions are based on sequence information and empirically derived rules but do not make use of the expression of microRNAs and their targets. This study aimed to improve microRNA target predictions in a given biological context, using in silico predictions, mi

  9. Word classes

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2007-01-01

    This article provides an overview of recent literature and research on word classes, focusing in particular on typological approaches to word classification. The cross-linguistic classification of word class systems (or parts-of-speech systems) presented in this article is based on statements found...... a parts-of-speech system that includes the categories Verb, Noun, Adjective and Adverb, other languages may use only a subset of these four lexical categories. Furthermore, quite a few languages have a major word class whose members cannot be classified in terms of the categories Verb – Noun – Adjective...

  10. Identification of conserved microRNAs and their targets in chickpea (Cicer arietinum L.).

    Science.gov (United States)

    Hu, Jihong; Sun, Lulu; Ding, Yi

    2013-04-01

    The microRNAs (miRNAs) are a new class of non-protein coding small RNAs that regulate gene expression at the post-transcriptional level in plants. Although thousands of miRNAs have been identified in many plant species, little studies have been reported about chickpea microRNAs. In this study, 28 potential miRNA candidates belonging to 20 families were identified from 16 ESTs and 12 GSSs in chickpea using a comparative genome-based computational analysis. A total of 664 miRNA targets were predicted and some of them encoded transcription factors as well as genes that function in stress response, signal transduction, methylation and a variety of other metabolic processes. These findings lay the foundation for further understanding of miRNA function in the development of chickpea.

  11. Roles of microRNAs in the life cycles of mammalian viruses.

    Science.gov (United States)

    Gottwein, Eva

    2013-01-01

    MicroRNAs (miRNAs) are a class of small noncoding RNAs expressed by plants, animals, and some viruses. miRNAs generally function as part of miRNA-induced silencing complexes to modestly repress mRNAs with imperfect sequence complementarity. Over the last years, many different roles of miRNA mediated regulation in the life cycles of mammalian viruses have been uncovered. In this chapter, I will mainly explore four different examples of how cellular miRNAs interact with viruses: the role of miR-155 in viral oncogenesis, viral strategies to eliminate cellular miR-27, the contribution of miR-122 to the replication of hepatitis C virus, and miRNAs as an experimental tool to control virus replication and vector transgene expression. In the final part of this chapter, I will give a brief overview of virally encoded microRNAs.

  12. MicroRNA Expression Profiling of the Porcine Developing Brain

    DEFF Research Database (Denmark)

    Podolska, Agnieszka; Kaczkowski, Bogumil; Busk, Peter Kamp

    2011-01-01

    MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most microRNA...... and the growth curve when compared to humans. Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain....

  13. MicroRNAs, epigenetics and disease

    DEFF Research Database (Denmark)

    Silahtaroglu, Asli; Stenvang, Jan

    2010-01-01

    Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules...... which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation...... diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer....

  14. Epigenetic microRNA Regulation

    DEFF Research Database (Denmark)

    Wiklund, Erik Digman

    2011-01-01

    MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that negatively regulate gene expression post-transcriptionally by binding to complementary sequences in the 3’UTR of target mRNAs in the cytoplasm. However, recent evidence suggests that certain miRNAs are enriched in the nucleus......, and their targets do not seem restricted to mRNA 3’UTRs. Therefore, miRNAs are predicted to have a variety functions throughout mammalian cells. MiRNA genes appear to be regulated in much the same way as coding genes, but current insight into transcriptional miRNA control lacks detail, as mapping miRNA promoters...... and confirming transcriptional start sites can be difficult. Epigenetics, gene regulatory and DNA modification mechanisms not involving a change to the primary sequence, have been implied in the regulation of a number of miRNA loci. Both epigenetic and miRNA signatures are broadly altered in cancer...

  15. MicroRNAs and spermatogenesis.

    Science.gov (United States)

    Kotaja, Noora

    2014-06-01

    In mammals, male gametes are produced inside the testis by spermatogenesis, which has three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid differentiation of spermatids. The genome of male germ cells is actively transcribed to produce phase-specific gene expression patterns. Male germ cells have a complex transcriptome. In addition to protein-coding messenger RNAs, many noncoding RNAs, including microRNAs (miRNAs), are produced. The miRNAs are important regulators of gene expression. They function mainly post-transcriptionally to control the stability or translation of their target messenger RNAs. The miRNAs are expressed in a cell-specific manner during spermatogenesis to participate in the control of each step of male germ cell differentiation. Genetically modified mouse models have demonstrated the importance of miRNA pathways for normal spermatogenesis, and functional studies have been designed to dissect the roles of specific miRNAs in distinct cell types. Clinical studies have exploited the well-defined expression profiles of miRNAs, and human spermatozoal or seminal plasma miRNAs have been explored as potential biomarkers for male factor infertility. This review article discusses the current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility.

  16. MicroRNAs in Metabolism

    DEFF Research Database (Denmark)

    Vienberg, Sara; Geiger, Julian; Madsen, Søren

    2017-01-01

    MicroRNAs (miRNAs) have within the past decade emerged as key regulators of metabolic homeostasis. Major tissues in intermediary metabolism important during development of the metabolic syndrome, such as β-cells, liver, skeletal and heart muscle as well as adipose tissue have all been shown to be...... diabetes and atherosclerosis stresses their potential as therapeutic targets. This review emphasizes current ideas and controversies within miRNA research in metabolism. This article is protected by copyright. All rights reserved.......MicroRNAs (miRNAs) have within the past decade emerged as key regulators of metabolic homeostasis. Major tissues in intermediary metabolism important during development of the metabolic syndrome, such as β-cells, liver, skeletal and heart muscle as well as adipose tissue have all been shown...... to be affected by miRNAs. In the pancreatic β-cell a number of miRNAs are important in maintaining the balance between differentiation and proliferation (miR-200 and miR-29 families) and insulin exocytosis in the differentiated state is controlled by miR-7, miR-375 and miR-335. MiR-33a and -33b play crucial...

  17. The Inter-Eruption Timescale of Classical Novae from Expansion of the Z Camelopardalis Shell

    CERN Document Server

    Shara, Michael M; Zurek, David; Martin, Christopher D; Neill, James D; Seibert, Mark

    2012-01-01

    The dwarf nova Z Camelopardalis is surrounded by the largest known classical nova shell. This shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts. The current size of the shell, its known distance, and the largest observed nova ejection velocity set a lower limit to the time since Z Cam's last outburst of 220 years. The brightest part of the Z Cam shell's radius is currently p ~ 1690 pixels. No expansion of the radius of the brightest part of the ejecta was detected, with an upper limit of pdot 5,000 years ago. However, including the important effect of deceleration as the ejecta sweeps up interstellar matter in its snowplow phase reduces the lower limit to 1300 years. This is the first strong test of the prediction of nova thermonuclear runaway theory that the inter-outburst times of classical novae are longer than 1000 yr. The intriguing suggestion ...

  18. Association of single nucleotide polymorphisms in the microRNA miR-1596 locus with residual feed intake in chickens.

    Science.gov (United States)

    Luo, C; Sun, L; Ma, J; Wang, J; Qu, H; Shu, D

    2015-06-01

    MicroRNAs are an abundant class of small non-coding RNAs that regulate gene expression. Genetic variations in microRNA sequences may be associated with phenotype differences by influencing the expression of microRNAs and/or their targets. This study identified two single nucleotide polymorphisms (SNPs) in the genomic region of the microRNA miR-1596 locus of chicken. Of the two SNPs, one was 95 bp upstream of miR-1596 (g.5678784A>T) and the other was in the middle of the sequence producing the mature microRNA gga-miR-1596-3p (g.5678944A>G). Genotypic distribution of the two SNPs had large differences among 12 chicken breeds (lines), especially between the fast-growing commercial lines and the slow-growing Chinese indigenous breeds for the g.5678784A>T SNP. Only the g.5678784A>T SNP was significantly associated with residual feed intake (RFI) in the F2 population derived from a fast-growing and a slow-growing broiler as well as in the pure Huiyang bearded chicken. The birds with the AA genotype of the g.5678784A>T SNP had lower RFI and higher expression of the mature gga-miR-1596-3p microRNA of miR-1596 than did those with the other genotypes of the same SNP. We also found that the expression of the mature gga-miR-1596-3p microRNA of miR-1596 was significantly associated with RFI. These findings suggest that miR-1596 can become a candidate gene related to RFI, and its genetic variation may contribute to changes in RFI by altering expression levels of the mature gga-miR-1596-3p microRNA in chicken. © 2015 Stichting International Foundation for Animal Genetics.

  19. SWIFT X-RAY OBSERVATIONS OF CLASSICAL NOVAE. II. THE SUPER SOFT SOURCE SAMPLE

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Greg J. [American Astronomical Society, 2000 Florida Avenue, NW, Suite 400, Washington, DC 20009-1231 (United States); Ness, Jan-Uwe [XMM-Newton Science Operations Centre, ESAC, Apartado 78, 28691 Villanueva de la Canada, Madrid (Spain); Osborne, J. P.; Page, K. L.; Evans, P. A.; Beardmore, A. P. [Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH (United Kingdom); Walter, Frederick M. [Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794-3800 (United States); Andrew Helton, L. [SOFIA Science Center, USRA, NASA Ames Research Center, M.S. N211-3, Moffett Field, CA 94035 (United States); Woodward, Charles E. [Minnesota Institute of Astrophysics, 116 Church Street S.E., University of Minnesota, Minneapolis, MN 55455 (United States); Bode, Mike [Astrophysics Research Institute, Liverpool John Moores University, Birkenhead CH41 1LD (United Kingdom); Starrfield, Sumner [School of Earth and Space Exploration, Arizona State University, P.O. Box 871404, Tempe, AZ 85287-1404 (United States); Drake, Jeremy J., E-mail: Greg.Schwarz@aas.org [Smithsonian Astrophysical Observatory, 60 Garden Street, MS 3, Cambridge, MA 02138 (United States)

    2011-12-01

    The Swift gamma-ray burst satellite is an excellent facility for studying novae. Its rapid response time and sensitive X-ray detector provides an unparalleled opportunity to investigate the previously poorly sampled evolution of novae in the X-ray regime. This paper presents Swift observations of 52 Galactic/Magellanic Cloud novae. We included the X-Ray Telescope (0.3-10 keV) instrument count rates and the UltraViolet and Optical Telescope (1700-8000 A) filter photometry. Also included in the analysis are the publicly available pointed observations of 10 additional novae the X-ray archives. This is the largest X-ray sample of Galactic/Magellanic Cloud novae yet assembled and consists of 26 novae with Super Soft X-ray emission, 19 from Swift observations. The data set shows that the faster novae have an early hard X-ray phase that is usually missing in slower novae. The Super Soft X-ray phase occurs earlier and does not last as long in fast novae compared to slower novae. All the Swift novae with sufficient observations show that novae are highly variable with rapid variability and different periodicities. In the majority of cases, nuclear burning ceases less than three years after the outburst begins. Previous relationships, such as the nuclear burning duration versus t{sub 2} or the expansion velocity of the eject and nuclear burning duration versus the orbital period, are shown to be poorly correlated with the full sample indicating that additional factors beyond the white dwarf mass and binary separation play important roles in the evolution of a nova outburst. Finally, we confirm two optical phenomena that are correlated with strong, soft X-ray emission which can be used to further increase the efficiency of X-ray campaigns.

  20. 2-phenylbenzotriazoles (PBTAs): a new class of environmental contaminants; 2-fenilbenzotriazois (PBTA): uma nova classe de contaminantes ambientais

    Energy Technology Data Exchange (ETDEWEB)

    Kummrow, Fabio [Universidade Federal de Alfenas, MG (Brazil). Dept. de Analises Clinicas e Toxicologicas]. E-mail: fabiok@unifal-mg.edu.br; Umbuzeiro, Gisela de Aragao [Companhia de Tecnologia de Saneamento Ambiental (CETESB), SP (Brazil). Div. de Toxicologia, Genotoxicidade e Microbiologia Ambiental

    2008-07-01

    This work is a literature review of PBTAs, the phenylbenzotriazoles generated from the reduction and chlorination of azo dyes. The PBTAs and the nonchlorinated PBTAs were isolated for the first time from river blue rayon organic extracts that showed high mutagenic activity in the Salmonella/microsome genotoxicity assay. To date, 8 PBTAs have been identified and beside their mutagenic activity in bacteria they cause genotoxic effects in fish and mammalian cell cultures. Due to the large number of textile dyeing facilities in Brazil, studies to determine them in the aquatic environment seem to be relevant. (author)

  1. A new twist in the microRNA pathway: Not Dicer but Argonaute is required for a microRNA production

    Institute of Scientific and Technical Information of China (English)

    Gabriel D Bossé; Martin J Simard

    2010-01-01

    @@ Found in all metazoans, microRNAs or miRNAs are small non-coding RNA of~22 nucleotides in length that completely reshaped our understanding of gene regulation. This new class of gene regulator is mostly transcribed by the RNA polymerase Ⅱ producing a long stem-loop structure, called primary-or pri-miRNA, that will first be processed in the cell nucleus by a multiprotein complex called microprocessor to generate a shorter RNA structure called precursor-or pre-miRNA.

  2. Psicologia Positiva: uma nova abordagem para antigas questões

    Directory of Open Access Journals (Sweden)

    Simone dos Santos Paludo

    2007-04-01

    Full Text Available Historicamente, a Psicologia preocupou-se em investigar patologias, negligenciado os aspectos saudáveis dos seres humanos. Mas, a partir de 1998, assumindo a presidência da American Psychological Association, Seligman iniciou movimento denominado Psicologia Positiva, que visa oferecer nova abordagem às potencialidades e virtudes humanas, estudando as condições e processos que contribuem para a prosperidade dos indivíduos e comunidades. Este artigo apresenta e discute essa nova proposta científica, que promete melhorar a qualidade de vida dos indivíduos e prevenir patologias; também as lacunas existentes nas investigações em Ciências Humanas, as contribuições teóricas e empíricas e as possíveis aplicações desse conhecimento.

  3. Nocardia nova mycetoma over forehead in a lepromatous leprosy patient.

    Science.gov (United States)

    Dhingra, M; Kaistha, N; Bansal, N; Solanki, L S; Chander, J; Thami, G P; van de Sande, W W

    2012-07-15

    We present a case of a 31-year-old male, a known patient with lepromatous leprosy with a type 2 lepra reaction, who presented with a slowly growing asymptomatic swelling with multiple discharging sinuses over the forehead that developed over 6 months. Smears of the serosanguinous discharge on Gram staining showed Gram-positive branching filamentous bacilli, which on culture on blood agar showed chalky-white colonies. Histology of the lesion showed suppurative granulomas with polymorphs surrounding characteristic grains. The isolate was identified as Nocardia nova by gene sequencing and the patient was started on combined antibiotic therapy that resulted in complete resolution of the infection in six months. To the best of our knowledge, this is the first report of mycetoma related to Nocardia nova in association with leprosy.

  4. Message Correlation Analysis Tool for NOvA

    CERN Document Server

    CERN. Geneva

    2012-01-01

    A complex running system, such as the NOvA online data acquisition, consists of a large number of distributed but closely interacting components. This paper describes a generic realtime correlation analysis and event identification engine, named Message Analyzer. Its purpose is to capture run time abnormalities and recognize system failures based on log messages from participating components. The initial design of analysis engine is driven by the DAQ of the NOvA experiment. The Message Analyzer performs filtering and pattern recognition on the log messages and reacts to system failures identified by associated triggering rules. The tool helps the system maintain a healthy running state and to minimize data corruption. This paper also describes a domain specific language that allows the recognition patterns and correlation rules to be specified in a clear and flexible way. In addition, the engine provides a plugin mechanism for users to implement specialized patterns or rules in generic languages such as C++.

  5. VERITAS OBSERVATIONS OF THE NOVA IN V407 CYGNI

    Energy Technology Data Exchange (ETDEWEB)

    Aliu, E. [Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027 (United States); Archambault, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Arlen, T. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Aune, T.; Bouvier, A. [Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Beilicke, M.; Buckley, J. H.; Bugaev, V.; Dickherber, R. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Benbow, W. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Bradbury, S. M. [School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT (United Kingdom); Byrum, K. [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Cannon, A.; Collins-Hughes, E. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Cesarini, A.; Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Ciupik, L. [Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605 (United States); Cui, W. [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Decerprit, G. [DESY, Platanenallee 6, 15738 Zeuthen (Germany); Duke, C., E-mail: daniel-d-gall@uiowa.edu, E-mail: kazuma-tsurusaki@uiowa.edu [Department of Physics, Grinnell College, Grinnell, IA 50112-1690 (United States); and others

    2012-07-20

    We report on very high energy (E > 100 GeV) gamma-ray observations of V407 Cygni, a symbiotic binary that underwent a nova outburst producing 0.1-10 GeV gamma rays during 2010 March 10-26. Observations were made with the Very Energetic Radiation Imaging Telescope Array System during 2010 March 19-26 at relatively large zenith angles due to the position of V407 Cyg. An improved reconstruction technique for large zenith angle observations is presented and used to analyze the data. We do not detect V407 Cygni and place a differential upper limit on the flux at 1.6 TeV of 2.3 Multiplication-Sign 10{sup -12} erg cm{sup -2} s{sup -1} (at the 95% confidence level). When considered jointly with data from Fermi-LAT, this result places limits on the acceleration of very high energy particles in the nova.

  6. VERITAS Observations of the Nova in V407 Cygni

    Science.gov (United States)

    Aliu, E.; Archambault, S.; Arlen, T.; Aune, T.; Beilicke, M.; Benbow, W.; Bouvier, A.; Bradbury, S. M.; Buckley, J. H.; Bugaev, V.; Byrum, K.; Cannon, A.; Cesarini, A.; Ciupik, L.; Collins-Hughes, E.; Connolly, M. P.; Cui, W.; Decerprit, G.; Dickherber, R.; Perkins, J. S.

    2012-01-01

    We report on very high energy (E > 100 GeV) gamma-ray observations of V407 Cygni, a symbiotic binary that underwent a nova outburst producing 0.1- 10 GeV gamma rays during 2010 March 10-26. Observations were made with the Very Energetic Radiation Imaging Telescope Array System during 2010 March 19-26 at relatively large zenith angles, due to the position of V407 Cyg. An improved reconstruction technique for large zenith angle observations is presented and used to analyze the data. We do not detect V407 Cygni and place a differential upper limit on the flux at 1.6 TeV of 2.3 10(exp -12) erg/sq cm/s (at the 95% confidence level). When considered jointly with data from Fermi-LAT, this result places limits on the acceleration of very high energy particles in the nova.

  7. VERITAS Observations of the Nova in V407 Cygni

    CERN Document Server

    Aliu, E; Arlen, T; Aune, T; Beilicke, M; Benbow, W; Bouvier, A; Bradbury, S M; Buckley, J H; Bugaev, V; Byrum, K; Cannon, A; Cesarini, A; Ciupik, L; Collins-Hughes, E; Connolly, M P; Cui, W; Decerprit, G; Dickherber, R; Duke, C; Dumm, J; Dwarkadas, V V; Errando, M; Falcone, A; Feng, Q; Finley, J P; Finnegan, G; Fortson, L; Furniss, A; Galante, N; Gall, D; Godambe, S; Griffin, S; Grube, J; Gyuk, G; Hanna, D; Holder, J; Huan, H; Hughes, G; Humensky, T B; Kaaret, P; Karlsson, N; Kertzman, M; Khassen, Y; Kieda, D; Krawczynski, H; Krennrich, F; Lang, M J; Lee, K; Maier, G; Majumdar, P; McArthur, S; McCann, A; Millis, J; Moriarty, P; Mukherjee, R; Nuñez, P D; Ong, R A; Orr, M; Otte, A N; Pandel, D; Park, N; Perkins, J S; Pohl, M; Prokoph, H; Quinn, J; Ragan, K; Reyes, L C; Reynolds, P T; Roache, E; Rose, H J; Ruppel, J; Saxon, D B; Schroedter, M; Sembroski, G H; Skole, C; Smith, A W; Staszak, D; Telezhinsky, I; Tešić, G; Theiling, M; Thibadeau, S; Tsurusaki, K; Tyler, J; Varlotta, A; Vincent, S; Vivier, M; Wakely, S P; Ward, J E; Weekes, T C; Weinstein, A; Weisgarber, T; Welsing, R; Williams, D A; Zitzer, B

    2012-01-01

    We report on very high energy (E > 100 GeV) gamma-ray observations of V407 Cygni, a symbiotic binary that underwent a nova outburst producing 0.1-10 GeV gamma rays during 2010 March 10-26. Observations were made with the Very Energetic Radiation Imaging Telescope Array System during 2010 March 19-26 at relatively large zenith angles, due to the position of V407 Cyg. An improved reconstruction technique for large zenith angle observations is presented and used to analyze the data. We do not detect V407 Cygni and place a differential upper limit on the flux at 1.6 TeV of 2.3 \\times 10^(-12) erg cm^(-2) s^(-1) (at the 95% confidence level). When considered jointly with data from Fermi-LAT, this result places limits on the acceleration of very high energy particles in the nova.

  8. Morpho-Kinematical Modelling of Nova Eridani 2009 (KT Eri)

    CERN Document Server

    Ribeiro, V A R M; Darnley, M J; Barnsley, R M; Munari, U; Harman, D J

    2013-01-01

    Modelling the morphology of a nova outburst provides valuable information on the shaping mechanism in operation at early stages following the outburst. We performed morpho-kinematical studies, using {\\sc shape}, of the evolution of the H\\alpha\\ line profile following the outburst of the nova KT Eridani. We applied a series of geometries in order to determine the morphology of the system. The best fit morphology was that of a dumbbell structure with a ratio between the major to minor axis of 4:1, with an inclination angle of 58$^{+6}_{-7}$ degrees and a maximum expansion velocity of 2800$\\pm$200 km/s. Although, we found that it is possible to define the overall structure of the system, the radial density profile of the ejecta is much more difficult to disentangle. Furthermore, morphology implied here may also be consistent with the presence of an evolved secondary as suggested by various authors.

  9. Nietzsche e a perspectiva de uma nova ética

    Directory of Open Access Journals (Sweden)

    Vânia Dutra de Azevedo

    2009-07-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2009v8n1p85Este artigo apresenta as possibilidades de uma nova perspectiva ética a partir do pensamento de Nietzsche.Essa nova ética tem como especifi cidade o fato de considerar as determinações profundas não conscientescomo prioritárias na defi nição do agir e por entender as éticas como construções explicativas e imposiçõesde uma dada interpretação que remetem a impulsos, forças e vontades de potência.

  10. The Thermonuclear Runaway and the Classical Nova Outburst

    CERN Document Server

    Starrfield, S; Hix, W R

    2016-01-01

    Nova explosions occur on the white dwarf component of a Cataclysmic Variable binary stellar system that is accreting matter lost by its companion. When sufficient material has been accreted by the white dwarf, a thermonuclear runaway occurs and ejects material in what is observed as a Classical Nova explosion. We describe both the recent advances in our understanding of the progress of the outburst and outline some of the puzzles that are still outstanding. We report on the effects of improving both the nuclear reaction rate library and including a modern nuclear reaction network in our one-dimensional, fully implicit, hydrodynamic computer code. In addition, there has been progress in observational studies of Supernovae Ia with implications about the progenitors and we discuss that in this review.

  11. Nova Centauri 2013 = PNV J13544700-5909080

    Science.gov (United States)

    Waagen, Elizabeth O.

    2013-12-01

    Announces the discovery of V1369 Cen = Nova Cen 2013 = PNV J13544700-5909080 by John Seach (Chatsworth Island, NSW, Australia) at unfiltered magnitude 5.5 on 2013 December 02.692 UT. Low-resolution spectra obtained by Locke on Dec. 03.3776 UT and by Kaufman on Dec. 03.621 UT show strong Ha and Hb emission lines, indicating the object is a nova. Announced on IAU CBAT Central Bureau Electronic Telegram 3732 (Daniel W. E. Green, ed.). Finder charts with sequences may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details and observations.

  12. Equation of state measurements of hydrogen isotopes on Nova

    Energy Technology Data Exchange (ETDEWEB)

    Collins, G.W.; Celliers, P.; Da Silva, L.B.; Cauble, R.; Gold, D.; Foord, M.; Budil, K.S.; Stewart, R.; Holmes, N.C.; Ross, M.; Hammel, B.A.; Kilkenny, J.D.; Wallace, R.J. [Lawrence Livermore National Laboratory, Livermore, California94550 (United States); Ng, A. [University of British Columbia, Vancouver, British Columbia (Canada)

    1998-05-01

    The Nova laser [E. M. Campbell, Laser Part. Beams {bold 9}, 209 (1991)] was used to shock-compress liquid deuterium and obtain new principal Hugoniot measurements of density and pressure between 0.3 and 2.1 Mbar. In this pressure-density region, deuterium is predicted to transform from a molecular insulating fluid to an atomic conducting fluid. Nova data show a rapid increase in density from 0.6 g/cc at 0.3 Mbar, to 1 g/cc at 0.6 Mbar, suggestive of such a transition. The observed sixfold compression near 1 Mbar is larger than predicted by many widely used equation of state models.

  13. Thermal stability and nova cycles in permanent superhump systems

    CERN Document Server

    Retter, A

    2000-01-01

    Archival data on permanent superhump systems are compiled to test the thermal stability of their accretion discs. We find that their discs are almost certainly thermally stable as expected. This result confirms Osaki's suggestion (1996) that permanent superhump systems form a new subclass of cataclysmic variables (CVs), with relatively short orbital periods and high mass transfer rates. We note that if the high accretion rates estimated in permanent superhump systems represent their mean secular values, then their mass transfer rates cannot be explained by gravitational radiation, therefore, either magnetic braking should be extrapolated to systems below the period gap or they must have mass transfer cycles. Alternatively, a new mechanism that removes angular momentum from CVs below the gap should be invoked. We suggest applying the nova cycle scenarios offered for systems above the period gap to the short orbital period CVs. Permanent superhumps have been observed in the two non-magnetic ex-novae with binary...

  14. High Energy Neutrino Physics with NOvA

    Energy Technology Data Exchange (ETDEWEB)

    Coan, Thomas [Southern Methodist Univ. , Dallas, TX (United States)

    2016-09-09

    Knowledge of the position of energy deposition in “hit” detector cells of the NOvA neutrino detector is required by algorithms for pattern reconstruction and particle identification necessary to interpret the raw data. To increase the accuracy of this process, the majority of NOvA's 350 000 far detector cell shapes, including distortions, were measured as they were constructed. Using a special laser scanning system installed at the site of the NOvA far detector in Ash River, MN, we completed algorithmic development and measured shape parameters for the far detector. The algorithm and the measurements are “published” in NOνA’s document database (doc #10389, “Cell Center Finder for the NOνA Far Detector Modules”).

  15. Functional MicroRNA Involved in Endometriosis

    Science.gov (United States)

    Creighton, Chad J.; Han, Derek Y.; Zariff, Azam; Anderson, Matthew L.; Gunaratne, Preethi H.; Matzuk, Martin M.

    2011-01-01

    Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we describe the first transcriptome-microRNAome analysis of endometriomas and eutopic endometrium using next-generation sequencing technology. Using this approach, we generated a total of more than 54 million independent small RNA reads from our 19 clinical samples. At the microRNA level, we found 10 microRNA that were up-regulated (miR-202, 193a-3p, 29c, 708, 509-3-5p, 574-3p, 193a-5p, 485-3p, 100, and 720) and 12 microRNA that were down-regulated (miR-504, 141, 429, 203, 10a, 200b, 873, 200c, 200a, 449b, 375, and 34c-5p) in endometriomas compared with endometrium. Using in silico prediction algorithms, we correlated these microRNA with their corresponding differentially expressed mRNA targets. To validate the functional roles of microRNA, we manipulated levels of miR-29c in an in vitro system of primary cultures of human endometrial stromal fibroblasts. Extracellular matrix genes that were potential targets of miR-29c in silico were significantly down-regulated using this biological in vitro system. In vitro functional studies using luciferase reporter constructs further confirmed that miR-29c directly affects specific extracellular matrix genes that are dysregulated in endometriomas. Thus, miR-29c and other abnormally regulated microRNA appear to play important roles in the pathophysiology of uterine function and dysfunction. PMID:21436257

  16. Novel role of microRNAs in prostate cancer

    Institute of Scientific and Technical Information of China (English)

    YU Jun-jie; XIA Shu-jie

    2013-01-01

    Objective To discuss the novel biomarkers of microRNAs in prostate cancer.Data sources The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012.Study selection Original articles regarding the novel role of microRNAs in prostate cancer were selected.Results MicroRNAs play an important role in prostate cancer such as cell differentiation,proliferation,apoptosis,and invasion.Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT),cancer stem cells (CSCs),drug sensitivity,cancer microenvironment,energy metabolism,androgen independence transformation,and diagnosis prediction.Conclusions MicroRNAs are involved in various aspects of prostate cancer biology.The role of microRNA in the initiation and development of prostate cancer deserves further study.

  17. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... bias from omitted variables, the preferred IV results indicate considerable negative effects due to larger class sizes and larger numbers of overage-for-grade peers. The latter, driven by the highly prevalent practices of grade repetition and academic redshirting, should be considered an important...

  18. Le stelle di Beatrice. Astronomia e astrologia nella "Vita Nova"

    OpenAIRE

    Maraldi, Elisa

    2015-01-01

    Ci sono due luoghi astronomici nella Vita Nova con i quali Dante calcola il tempo in cui si verificano gli episodi principali della storia narrata. Queste nozioni scientifiche contengono implicito un significato astrologico, connesso all’influsso del segno zodiacale dei Gemelli, configurazione astrologica che torna ad ogni anniversario. I Gemelli è il segno zodiacale di Dante, come il poeta afferma nella Commedia: l’invocazione del pellegrino alla costellazione omonima, alla cui influenza egl...

  19. Three new optical nova candidates in M 31

    Science.gov (United States)

    Pietsch, W.; Henze, M.; Burwitz, V.; Kaur, A.; Hartmann, D. H.; Williams, G.; Milne, P.

    2011-06-01

    We report the discovery of three nova candidates in M 31 on 7x60s stacked R filter CCD images obtained with the robotic 60cm telescope with an E2V CCD (2kx2k, 13.5 micron sq. pixels) of the Livermore Optical Transient Imaging System (Super-LOTIS, located at Steward Observatory, Kitt Peak, Arizona, USA) on 2011 June 7.418 UT. The objects are visible on all individual images.

  20. Online resources for microRNA analysis

    Directory of Open Access Journals (Sweden)

    Panagiotis Alexiou

    2011-02-01

    Full Text Available The use of online tools for bioinformatics analyses is becoming increasingly widespread. Resources specific to the field of microRNAs are available, varying in scope and usability. Online tools are the most useful for casual as well as power users since they need no installation, are hardware independent and are used mostly through graphic user interfaces and links to external sources. Here, we present an overview of useful online resources that have to do with microRNA genomics, gene finding, target prediction and functional analysis.

  1. A class of generalized beta distributions, Pareto power series and Weibull power series

    OpenAIRE

    Lemos de Morais, Alice

    2009-01-01

    Nesta dissertação trabalhamos com três classes de distribuições de probabilidade, sendo uma já conhecida na literatura, a Classe de Distribuições Generalizadas Beta (Beta-G) e duas outras novas classes introduzidas nesta tese, baseadas na composição das distribuições Pareto e Weibull com a classe de distribuições discretas power series. Fazemos uma revisão geral da classe Beta-G e introduzimos um caso especial, a distribuição beta logística generalizada do tipo IV (BGL(IV)). In...

  2. An evaluation of Nova Scotia's alcohol ignition interlock program.

    Science.gov (United States)

    Vanlaar, Ward G M; Mainegra Hing, Marisela; Robertson, Robyn D

    2017-03-01

    Alcohol ignition interlock programs for offenders aim to reduce recidivism among convicted drink drivers. This study presents an evaluation of Nova Scotia's interlock program implemented in 2008 in order to assess its effectiveness to reduce impaired driving and to help identify areas for improvement. Data used include conviction and crash records of individual participants; provincial monthly counts of alcohol-related charges, convictions and fatal and serious crashes; and interlock logged events. Methods used include descriptive statistics, survival analysis, time series and logistic regression analysis. With respect to specific deterrence (i.e., preventing recidivism) there was a 90% reduction in recidivism among voluntary participants since participation in the interlock program and a 79% reduction after these participants exited from the program. With respect to general deterrence (i.e., referring to a preventative effect on the entire population of drivers in Nova Scotia) there were temporary decreases in the numbers of alcohol-related charges (13.32%) and convictions (9.93%) and a small significant decrease in the number of fatal and serious injury alcohol-related crashes, following the implementation of the program. The evidence suggests the interlock program was better at preventing harm due to alcohol-impaired driving than the alternative of not using the interlock program. Recommendations were formulated supporting the continuation of the interlock program in Nova Scotia.

  3. Novae as Tevatrons: Prospects for CTA and IceCube

    CERN Document Server

    Metzger, Brian D; Vurm, Indrek; Beloborodov, Andrei; Bartos, Imre; Vlasov, Andrey

    2015-01-01

    The discovery of novae as sources of ~GeV gamma-rays highlights the key role of shocks and relativistic particle acceleration in these transient systems. Although there is evidence for a spectral cut-off above energies ~1-100 GeV at particular epochs in some novae, the maximum particle energy achieved in these accelerators has remained an open question. The high densities of the nova ejecta (~10 orders of magnitude larger than in supernova remnants) render the gas far upstream of the shock neutral and shielded from ionizing radiation. The amplification of the magnetic field needed for diffusive shock acceleration requires ionized gas, thus confining the acceleration process to a narrow photo-ionized layer immediately ahead of the shock. Based on the growth rate in this layer of the hybrid non-resonant cosmic ray current-driven instability (considering also ion-neutral damping), we quantify the maximum particle energy, Emax, across the range of shock velocities and upstream densities of interest. We find value...

  4. Nova Scotia S-2000 monitoring project. Vol. 1, Performance summary

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, P.; Harrison, S.J. [Queen`s Univ., Kingston, ON (Canada). Solar Calorimetry Lab.

    1994-12-01

    Electric utility companies have increasingly been evaluating and implementing demand management and conservation. As a result there has been growing interest in potential energy savings and capacity benefits of Solar Domestic Hot Water (SDHW) technologies. A computer simulation study showed that SDHW can provide significant savings in hot water heating. Natural Resources Canada through the Canada Centre for Mineral and Energy Technology (CANMET) initiated the S-2000 program. The S-2000 program was initiated to promote cooperation between CANMET, electric utilities and provincial governments interested in determining whether SDHW systems can reduce peak energy demand and pollution emissions. 60 SDHW systems were installed in Nova Scotia. Systems were monitored by Thermo Dynamics Limited and analyzed by the Solar Calorimetry Laboratory at Queen`s University. Results were produced for the monitoring period from October 1993 to August 1994. Results for 32 of the Nova Scotia systems showed winter and summer solar energy supplies of 14.8 MWh and 30 MWh respectively. The system efficiency was determined to be 28.4%. The system performance was consistent with predictions made from computer simulations, with the exception of an unexpectedly severe winter. The solar energy contribution during the winter was lower than that predicted for typical weather conditions. Of the systems monitored daily average hot water use was lower than the reference 239 L/day value. Monitoring of the Nova Scotia systems will continue through 1995 and strategies will be investigated. 15 figs., 5 tables

  5. Shocks in nova outflows. II. Synchrotron radio emission

    CERN Document Server

    Vlasov, Andrey Dmitrievich; Metzger, Brian David

    2016-01-01

    The discovery of GeV gamma-rays from classical novae indicates that shocks and relativistic particle acceleration are energetically key in these events. Further evidence for shocks comes from thermal keV X-ray emission and an early peak in the radio light curve on a timescale of months with a brightness temperature which is too high to result from freely expanding photo-ionized gas. Paper I developed a one dimensional model for the thermal emission from nova shocks. This work concluded that the shock-powered radio peak cannot be thermal if line cooling operates in the post-shock gas at the rate determined by collisional ionization equilibrium. Here we extend this calculation to include non-thermal synchrotron emission. Applying our model to three classical novae, we constrain the amplification of the magnetic field $\\epsilon_B$ and the efficiency $\\epsilon_e$ of accelerating relativistic electrons of characteristic Lorentz factor $\\gamma \\sim 100$. If the shocks are radiative (low velocity $v_{\\rm sh} \\lesssi...

  6. Observational Report of the Classical Nova KT Eridani

    CERN Document Server

    Imamura, Kazuyoshi

    2012-01-01

    A report on the spectroscopic and multi-color photometric observations of high galactic latitude classical nova KT Eridani (Nova Eridani 2009) is presented. After 12.2 days from maximum light, broad and prominent emission lines of Balmer series, He I, He II, N II, N III and O I can be seen on the spectra. The FWHM of H${\\alpha}$ line yields an expansion velocity of approximately 3400 km s$^{-1}$. After 279.4 days from maximum light, we can see prominent emission lines of He II and [O III] on the spectrum. Among them, [O III] (4959, 5007) lines show multiple peaks. From the obtained light curve, KT Eri is classified to be a very fast nova, with a decline rate by two magnitude of $6.2 \\pm 0.3$ days and three of $14.3 \\pm 0.7$ days. We tried to estimate the absolute magnitude ($M_V$) using the Maximum Magnitude versus Rate of Decline relationship and distance of KT Eri. The calculated $M_V$ is approximately -9. Accordingly, the distance and galactic height are approximately 7 kpc and 4 kpc, respectively. Hence, ...

  7. Searching for magnetar powered merger-novae from short GRBs

    CERN Document Server

    Gao, He; Lü, Hou-Jun; Li, Ye

    2016-01-01

    The merger of a double neutron star (NS-NS) binary may result in a rapidly rotating massive NS with an extremely strong magnetic field (i.e., a millisecond magnetar). In this case, the magnetic spin-down of the NS remnant provides an additional source of sustained energy injection, which would continuously power the merger ejecta. The thermal emission from the merger ejecta would give rise to a bright optical "magnetar-powered merger-nova". In this work, we carry out a complete search for magnetar-powered merger-nova from \\emph{Swift} short gamma-ray burst (SGRB) sample. We focus on short GRBs with extended emission or internal plateau, which may signify the presence of magnetars as the central engine. We eventually find three candidates of "magnetar-powered merger-nova" from the late observations of GRB 050724, GRB 070714B and GRB 061006. With standard parameter values, the magentar remnant scenario could well interpret the multi-band data of all three bursts, including the extended emission and their late c...

  8. Spectral Evolution of the Unusual Slow Nova V5558 Sgr

    CERN Document Server

    Tanaka, Jumpei; Fujii, Mitsugu; Ayani, Kazuya; Kato, Taichi; Maehara, Hiroyuki; Kiyota, Seiichiro; Nakajima, Kazuhiro

    2011-01-01

    We report on the spectral evolution of the enigmatic, very slow nova V5558 Sgr, based on the low-resolution spectra obtained at the Fujii-Bisei Observatory and the Bisei Astronomical Observatory, Japan during a period of 2007 April 6 to 2008 May 3. V5558 Sgr shows a pre-maximum halt and then several flare-like rebrightenings, which is similar to another very slow nova V723 Cas. In our observations, the spectral type of V5558 Sgr evolved from the He/N type toward the Fe II type during the pre-maximum halt, and then toward the He/N type again. This course of spectral transition was observed for the first time in the long history of the nova research. In the rebrightening stage after the initial brightness maximum, we could identify many emission lines accompanied by a stronger absorption component of the P-Cygni profile at the brightness maxima. We found that the velocity of the P-Cygni absorption component measured from the emission peak decreased at the brightness maxima. Furthermore, we compared the spectra ...

  9. Direct Three-body Triple-$\\alpha$ in Helium Novae

    CERN Document Server

    Connolly, Ryan; Brown, Edward F

    2016-01-01

    In AM CVn binaries, a white dwarf primary accretes material from a helium-rich white dwarf or stellar companion. The unstable ignition of nuclear burning via the $3\\alpha$ reaction in an accumulated helium layer powers a thermonuclear runaway near accretion rates $\\dot{M} \\lesssim 10^{-6} \\, \\mathrm{M_{\\odot} \\ yr^{-1}}$ that may be observed as helium nova or .Ia supernova. Helium burning in the primary's envelope at temperatures $T \\lesssim 10^{8} \\, \\mathrm{K}$ may proceed via the direct three-body fusion of $\\alpha$-particles. Here we show that the direct three-body rate by Nguyen et al. (2012) -- which is reduced relative to the extrapolated resonant rate at temperatures $T \\gtrsim 5 \\times 10^{7} \\, \\mathrm{K}$ -- results in novae with longer recurrence times and larger ignition masses. By contrast, we find that the enhancement in the direct three-body rate at temperatures below $T \\lesssim 5 \\times 10^{7} \\, \\mathrm{K}$ does not result in significant differences in nova outburst properties. The most mas...

  10. Intial performance from the NOvA surface prototype detector

    Energy Technology Data Exchange (ETDEWEB)

    Muether, M.; /Fermilab

    2011-09-01

    NOvA, the NuMI Off-Axis {nu}{sub e} Appearance experiment, will study {nu}{sub {mu}} {yields} {nu}{sub e} oscillations characterized by the mixing angle {Theta}{sub 13}. Provided {Theta}{sub 13} is large enough, NOvA may ultimately determine the ordering of the neutrino masses and measure CP violation in neutrino oscillations. A complementary pair of detectors will be constructed {approx}14 mrad off beam axis to optimize the energy profile of the neutrinos. This system consists of a surface based 14 kTon liquid scintillator tracking volume located 810 km from the main injector source (NuMI) in Ash River, Minnesota and a smaller underground 222 Ton near detector at the Fermilab. The first neutrino signals at the Ash River Site are expected prior to the 2012 accelerator shutdown. In the meantime, a near detector surface prototype has been completed and neutrinos from two Fermilab sources have been observed using the same highly segmented PVC and liquid scintillator detector system that will be deployed in the full scale experiment. Design and initial performance characteristics of this prototype system are being fed back into the design for the full NOvA program.

  11. Radiative shocks create environments for dust formation in novae

    CERN Document Server

    Derdzinski, Andrea M; Lazzati, Davide

    2016-01-01

    Classical novae commonly show evidence of rapid dust formation within months of the outburst. However, it is unclear how molecules and grains are able to condense within the ejecta given the potentially harsh environment created by ionizing radiation from the white dwarf. Motivated by the evidence for powerful radiative shocks within nova outflows, we propose that dust formation occurs within the cool, dense shell behind these shocks. We incorporate a simple molecular chemistry network and classical nucleation theory with a model for the thermodynamic evolution of the post-shock gas to demonstrate the formation of both carbon and forsterite ($\\rm Mg_2SiO_4$) grains. The high densities due to radiative shock compression ($n \\sim 10^{14}$ cm$^{-3}$) result in CO saturation and rapid dust nucleation. Grains grow efficiently to large sizes $\\gtrsim 0.1\\mu$m, in agreement with IR observations of dust-producing novae, and with total dust masses sufficient to explain massive extinction events such as V705 Cas. As in...

  12. Prediction of viral microRNA precursors based on human microRNA precursor sequence and structural features.

    Science.gov (United States)

    Kumar, Shiva; Ansari, Faraz A; Scaria, Vinod

    2009-08-20

    MicroRNAs (small approximately 22 nucleotide long non-coding endogenous RNAs) have recently attracted immense attention as critical regulators of gene expression in multi-cellular eukaryotes, especially in humans. Recent studies have proved that viruses also express microRNAs, which are thought to contribute to the intricate mechanisms of host-pathogen interactions. Computational predictions have greatly accelerated the discovery of microRNAs. However, most of these widely used tools are dependent on structural features and sequence conservation which limits their use in discovering novel virus expressed microRNAs and non-conserved eukaryotic microRNAs. In this work an efficient prediction method is developed based on the hypothesis that sequence and structure features which discriminate between host microRNA precursor hairpins and pseudo microRNAs are shared by viral microRNA as they depend on host machinery for the processing of microRNA precursors. The proposed method has been found to be more efficient than recently reported ab-initio methods for predicting viral microRNAs and microRNAs expressed by mammals.

  13. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byeong-Moo [Department of Medicine/GI Unit, Massachusetts General Hospital, Boston, MA 02114 (United States); Department of Medicine, Harvard Medical School, Boston, MA 02115 (United States); Choi, Michael Y., E-mail: mchoi@partners.org [Department of Medicine/GI Unit, Massachusetts General Hospital, Boston, MA 02114 (United States); Department of Medicine, Harvard Medical School, Boston, MA 02115 (United States); Harvard Stem Cell Institute, Boston, MA 02114 (United States)

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  14. Evolution of Nova TrA 2008 into a High Mass-Accretion Rate Post-Nova

    Science.gov (United States)

    Walter, Frederick M.

    2015-06-01

    NR TrA (Nova TrA 2008) was a normal slow Fe II novae for its first year of evolution. During its third year eclipses appeared, and optical spectra revealed the presence of hot permitted lines of C IV, N V, and O VI in addition to the usual nebular lines. The light curve and spectra resemble those of the V Sge stars. The orbital period is 5.25 hours. The time-resolved spectra show a prominent S-wave in the hot lines with an amplitude of about 100 km/s. We conclude that the system is a CV with a high mass accretion rate that has persisted for some 6 years after the explosion.

  15. Optical spectral evolution of Nova Cygni 1992 = V 1974 Cygni

    Science.gov (United States)

    Rafanelli, P.; Rosino, L.; Radovich, M.

    1995-02-01

    We report the results of the optical spectrophotometric observations of N Cyg 1992 = V 1974 Cyg performed at Asiago between 6 and 670 days after its visual maximum (1992 February 22, mv approximately 4.4). On 1992 February 28, during the first decline the spectrum of the nova was characterized by the presence over a strong continuum of wide emission lines of HI (Balmer), FeII, NaI, CaII, flanked by two systems of P Cyg absorptions with mean radial velocities of -1250 and -1900 km/s. The transition phase was reached at the beginning of April with a gradual fading of the lines of lower ionization potential and the emerging of the HeI, NII, NIII lines. P Cygni absorption features with radial velocity higher than in February were still perceptible. The nova entered the nebular stage some weeks later, at the end of April. The presence in the spectrum, besides (OIII) lambda lambda 4959, 5007, of strong forbidden lines of (NeIII) at lambda lambda 3869, 3968, left no doubt of its classification as a 'neon nova' similar to QU Vul. The evolution of the spectrum in the next months was characterized by the progressive growth of the ionization degree. Following the forbidden lines of (NeIII) and (OIII), also those of (NeIV), (FeVI), (FeVII) and (NeV) became outstanding. The highest degree of ionization was attained on 1993 July, about 500 days from visual maximum, when the coronal lines of (FeX), (FeXI), (AX) reached their highest strength. The steadily decline of the degree of ionization began about one-hundred days later, with the rapid disappearance of the coronal lines and the progressive fading of the lines of highest ionization potential. The intensities of the emission lines during the nova evolution are reported. The discussion concerns the determination of: color excess, absolute magnitude and distance (2.8 kpc) of the nova; effective temperature of the contracting photosphere; and abundance in the ejecta of He, O, N, and Ne, relative to H.

  16. Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum.

    Science.gov (United States)

    Leite, Daniel J; Ninova, Maria; Hilbrant, Maarten; Arif, Saad; Griffiths-Jones, Sam; Ronshaugen, Matthew; McGregor, Alistair P

    2016-08-03

    MicroRNAs are small (∼22 nt) noncoding RNAs that repress translation and therefore regulate the production of proteins from specific target mRNAs. microRNAs have been found to function in diverse aspects of gene regulation within animal development and many other processes. Among invertebrates, both conserved and novel, lineage specific, microRNAs have been extensively studied predominantly in holometabolous insects such as Drosophila melanogaster However little is known about microRNA repertoires in other arthropod lineages such as the chelicerates. To understand the evolution of microRNAs in this poorly sampled subphylum, we characterized the microRNA repertoire expressed during embryogenesis of the common house spider Parasteatoda tepidariorum We identified a total of 148 microRNAs in P. tepidariorum representing 66 families. Approximately half of these microRNA families are conserved in other metazoans, while the remainder are specific to this spider. Of the 35 conserved microRNAs families 15 had at least two copies in the P. tepidariorum genome. A BLAST-based approach revealed a similar pattern of duplication in other spiders and a scorpion, but not among other chelicerates and arthropods, with the exception of a horseshoe crab. Among the duplicated microRNAs we found examples of lineage-specific tandem duplications, and the duplication of entire microRNA clusters in three spiders, a scorpion, and in a horseshoe crab. Furthermore, we found that paralogs of many P. tepidariorum microRNA families exhibit arm switching, which suggests that duplication was often followed by sub- or neofunctionalization. Our work shows that understanding the evolution of microRNAs in the chelicerates has great potential to provide insights into the process of microRNA duplication and divergence and the evolution of animal development.

  17. MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma.

    Science.gov (United States)

    Sandoval, Juan; Díaz-Lagares, Angel; Salgado, Rocío; Servitje, Octavio; Climent, Fina; Ortiz-Romero, Pablo L; Pérez-Ferriols, Amparo; Garcia-Muret, Maria P; Estrach, Teresa; Garcia, Mar; Nonell, Lara; Esteller, Manel; Pujol, Ramon M; Espinet, Blanca; Gallardo, Fernando

    2015-04-01

    MicroRNAs usually regulate gene expression negatively, and aberrant expression has been involved in the development of several types of cancers. Microarray profiling of microRNA expression was performed to define a microRNA signature in a series of mycosis fungoides tumor stage (MFt, n=21) and CD30+ primary cutaneous anaplastic large cell lymphoma (CD30+ cALCL, n=11) samples in comparison with inflammatory dermatoses (ID, n=5). Supervised clustering confirmed a distinctive microRNA profile for cutaneous T-cell lymphoma (CTCL) with respect to ID. A 40 microRNA signature was found in MFt including upregulated onco-microRNAs (miR-146a, miR-142-3p/5p, miR-21, miR-181a/b, and miR-155) and downregulated tumor-suppressor microRNAs (miR-200ab/429 cluster, miR-10b, miR-193b, miR-141/200c, and miR-23b/27b). Regarding CD30+ cALCL, 39 differentially expressed microRNAs were identified. Particularly, overexpression of miR-155, miR-21, or miR-142-3p/5p and downregulation of the miR-141/200c clusters were observed. DNA methylation in microRNA gene promoters, as expression regulatory mechanism for deregulated microRNAs, was analyzed using Infinium 450K array and approximately one-third of the differentially expressed microRNAs showed significant DNA methylation differences. Two different microRNA methylation signatures for MFt and CD30+ cALCL were found. Correlation analysis showed an inverse relationship for microRNA promoter methylation and microRNA expression. These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.

  18. A micro-RNA expression signature for human NAFLD progression.

    Science.gov (United States)

    Guo, Yan; Xiong, Yanhua; Sheng, Quanghu; Zhao, Shilin; Wattacheril, Julia; Flynn, Charles Robb

    2016-10-01

    The spectrum of nonalcoholic fatty liver disease (NAFLD) describes disease conditions deteriorating from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to cirrhosis (CIR) to hepatocellular carcinoma (HCC). From a molecular and biochemical perspective, our understanding of the etiology of this disease is limited by the broad spectrum of disease presentations, the lack of a thorough understanding of the factors contributing to disease susceptibility, and ethical concerns related to repeat sampling of the liver. To better understand the factors associated with disease progression, we investigated by next-generation RNA sequencing the altered expression of microRNAs (miRNAs) in liver biopsies of class III obese subjects (body mass index ≥40 kg/m(2)) biopsied at the time of elective bariatric surgery. Clinical characteristics and unbiased RNA expression profiles for 233 miRs, 313 transfer RNAs (tRNAs), and 392 miscellaneous small RNAs (snoRNAs, snRNAs, rRNAs) were compared among 36 liver biopsy specimens stratified by disease severity. The abundances of 3 miRNAs that were found to be differentially regulated (miR-301a-3p and miR-34a-5p increased and miR-375 decreased) with disease progression were validated by RT-PCR. No tRNAs or miscellaneous RNAs were found to be associated with disease severity. Similar patterns of increased miR-301a and decreased miR-375 expression were observed in 134 hepatocellular carcinoma (HCC) samples deposited in The Cancer Genome Atlas (TCGA). Our analytical results suggest that NAFLD severity is associated with a specific pattern of altered hepatic microRNA expression that may drive the hallmark of this disorder: altered lipid and carbohydrate metabolism. The three identified miRNAs can potentially be used as biomarkers to access the severity of NAFLD. The persistence of this miRNA expression pattern in an external validation cohort of HCC samples suggests that specific microRNA expression patterns may permit and

  19. Fermi-LAT detection of the Galactic nova TCP J18102829-2729590

    Science.gov (United States)

    Li, Kwan-Lok; Chomiuk, Laura

    2016-11-01

    Fermi-LAT detection of the Galactic nova TCP J18102829-2729590 Following the discovery of the nova in Sagittarius TCP J18102829-2729590 (CBAT 2016 10 20.383; ATel #9658), we triggered an one-week Fermi ToO (observation number: 090603-1-1; PI: Laura Chomiuk) from 2016-10-25 as part of our Fermi-LAT monitoring campaign for Galactic novae (ATel #9311).

  20. THE INTER-ERUPTION TIMESCALE OF CLASSICAL NOVAE FROM EXPANSION OF THE Z CAMELOPARDALIS SHELL

    Energy Technology Data Exchange (ETDEWEB)

    Shara, Michael M.; Mizusawa, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024-5192 (United States); Martin, Christopher D.; Neill, James D. [Department of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Mail Code 405-47, Pasadena, CA 91125 (United States); Seibert, Mark [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2012-09-10

    The dwarf nova Z Camelopardalis is surrounded by the largest known classical nova shell. This shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts. The current size of the shell, its known distance, and the largest observed nova ejection velocity set a lower limit to the time since Z Cam's last outburst of 220 years. The radius of the brightest part of Z Cam's shell is currently {approx}880 arcsec. No expansion of the radius of the brightest part of the ejecta was detected, with an upper limit of {<=}0.17 arcsec yr{sup -1}. This suggests that the last Z Cam eruption occurred {>=}5000 years ago. However, including the important effect of deceleration as the ejecta sweeps up interstellar matter in its snowplow phase reduces the lower limit to 1300 years. This is the first strong test of the prediction of nova thermonuclear runaway theory that the interoutburst times of classical novae are longer than 1000 years. The intriguing suggestion that Z Cam was a bright nova, recorded by Chinese imperial astrologers in October-November 77 B.C.E., is consistent with our measurements. If Z Cam was indeed the nova of 77 B.C.E. we predict that its ejecta are currently expanding at 85 km s{sup -1}, or 0.11 arcsec yr{sup -1}. Detection and measurement of this rate of expansion should be possible in just a few years.

  1. MicroRNA transcriptome profiles during swine skeletal muscle development

    Directory of Open Access Journals (Sweden)

    Sonstegard Tad S

    2009-02-01

    Full Text Available Abstract Background MicroRNA (miR are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts. To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, three stages of fetal growth, day-old neonate, and the adult. Results Twelve potential novel miR were detected that did not match previously reported sequences. In addition, a number of miR previously reported to be expressed in mammalian muscle were detected, having a variety of abundance patterns through muscle development. Muscle-specific miR-206 was nearly absent in proliferating satellite cells in culture, but was the highest abundant miR at other time points evaluated. In addition, miR-1 was moderately abundant throughout developmental stages with highest abundance in the adult. In contrast, miR-133 was moderately abundant in adult muscle and either not detectable or lowly abundant throughout fetal and neonate development. Changes in abundance of ubiquitously expressed miR were also observed. MiR-432 abundance was highest at the earliest stage of fetal development tested (60 day-old fetus and decreased throughout development to the adult. Conversely, miR-24 and miR-27 exhibited greatest abundance in proliferating satellite cells and the adult, while abundance of miR-368, miR-376, and miR-423-5p was greatest in the neonate. Conclusion These data present a complete set of transcriptome profiles to evaluate miR abundance at specific stages of skeletal muscle growth in swine. Identification of these miR provides an initial group of miR that may play a vital role in muscle development and growth.

  2. Deregulated microRNAs in multiple myeloma.

    Science.gov (United States)

    Benetatos, Leonidas; Vartholomatos, George

    2012-02-15

    MicroRNAs are short noncoding RNAS involved in gene expression regulation under physiological and pathological situations. They bind to mRNA of target genes and are potential regulators of gene expression at a post-transcription level through the RNA interference pathway. They are estimated to represent 1% to 2% of the known eukaryotic genome, and it has been demonstrated that they are involved in the pathogenesis of neurodegenerative diseases, cancer, metabolism disorders, and heart disease. MicroRNAs are known to act as tumor suppressors or oncogenes in cancer biology. The authors describe the current knowledge on microRNA involvement in regulatory pathways that characterize multiple myeloma pathogenesis gained from in vitro and in vivo studies. These small molecules interact with important factors such as p53, SOCS1, IGF-1, IGF-1R, vascular endothelial growth factor, NF-κB, and others. As such, microRNAs represent an attractive therapeutic target in the context of multiple myeloma interfering with the myeloma regulatory networks. Further studies are needed to better understand their role in myelomagenesis and their therapeutic potential.

  3. microRNA in Human Reproduction.

    Science.gov (United States)

    Eisenberg, Iris; Kotaja, Noora; Goldman-Wohl, Debra; Imbar, Tal

    2015-01-01

    microRNAs constitute a large family of approximately 21-nucleotide-long, noncoding RNAs. They emerged more than 20 years ago as key posttranscriptional regulators of gene expression. The regulatory role of these small RNA molecules has recently begun to be explored in the human reproductive system. microRNAs have been shown to play an important role in control of reproductive functions, especially in the processes of oocyte maturation, folliculogenesis, corpus luteum function, implantation, and early embryonic development. Knockout of Dicer, the cytoplasmic enzyme that cleaves the pre-miRNA to its mature form, results in postimplantation embryonic lethality in several animal models, attributing to these small RNA vital functions in reproduction and development. Another intriguing characteristic of microRNAs is their presence in body fluids in a remarkably stable form that is protected from endogenous RNase activity. In this chapter we will describe the current knowledge on microRNAs, specifically relating to human gonadal cells. We will focus on their role in the ovarian physiologic process and ovulation dysfunction, regulation of spermatogenesis and male fertility, and putative involvement in human normal and aberrant trophoblast differentiation and invasion through the process of placentation.

  4. Studying microRNAs in lymphoma

    NARCIS (Netherlands)

    Kluiver, Joost; Slezak-Prochazka, Izabella; van den Berg, Anke

    2013-01-01

    MicroRNAs (miRNAs) play important roles in development, differentiation, homeostasis, and also in diseases such as lymphoma. This chapter describes methods to study the role of miRNAs in lymphoma. First, we describe a multiplex RT reaction followed by qPCR that can be used to determine differential

  5. MicroRNA mimicry blocks pulmonary fibrosis

    NARCIS (Netherlands)

    Montgomery, Rusty L; Yu, Guoying; Latimer, Paul A; Stack, Christianna; Robinson, Kathryn; Dalby, Christina M; Kaminski, Naftali; van Rooij, Eva

    2014-01-01

    Over the last decade, great enthusiasm has evolved for microRNA (miRNA) therapeutics. Part of the excitement stems from the fact that a miRNA often regulates numerous related mRNAs. As such, modulation of a single miRNA allows for parallel regulation of multiple genes involved in a particular diseas

  6. Beginning to understand microRNA function

    Institute of Scientific and Technical Information of China (English)

    Tingting Du; Phillip D Zamore

    2007-01-01

    @@ MicroRNAs (miRNAs) are -22 nt small RNAs expressed by plants, animals, viruses and at least one unicellular organism, the green alga, Chlamydomonas reinhardtii [1]. Most miRNAs are transcribed as primary miRNAs (pri-miRNAs) by RNA polymerase Ⅱ, although a few are transcribed by RNA polymerase Ⅲ.

  7. Classical Novae in Andromeda: Light Curves from the Palomar Transient Factory and GALEX

    CERN Document Server

    Cao, Yi; Neill, James D; Kulkarni, S R; Lou, Yu-Qing; Ben-Ami, Sagi; Bloom, Joshua S; Cenko, S Bradley; Law, Nicholas M; Nugent, Peter E; Ofek, Eran O; Poznanski, Dovi; Quimby, Robert M

    2012-01-01

    We present optical light curves of twenty-nine novae in M31 during the 2009 and 2010 observing seasons of the Palomar Transient Factory (PTF). The dynamic and rapid cadences in PTF monitoring of M31, from one day to even ten minutes, provide excellent temporal coverage of nova light curves, enabling us to record the photometric evolution of M31 novae in unprecedented detail. We also detect eight of these novae in the near ultraviolet (UV) band with the Galaxy Evolution Explorer (GALEX) satellite. Novae M31N2009-10b and 2010-11a show prominent UV emission peaking a few days prior to their optical maxima, possibly implying aspherical outbursts. Additionally, our blue-shifted spectrum of the recent outburst of PT And (M31N2010-12a) indicates that it is a recurrent nova in M31 and not a dwarf nova in the Milky Way as was previously assumed. Finally, we systematically searched for novae in all confirmed globular clusters of M31 and found only M31N 2010-10f associated with Bol 126. The specific nova rate in the M31...

  8. CLASSICAL NOVAE IN ANDROMEDA: LIGHT CURVES FROM THE PALOMAR TRANSIENT FACTORY AND GALEX

    Energy Technology Data Exchange (ETDEWEB)

    Cao Yi; Lou Yuqing [Tsinghua Center for Astrophysics (THCA), Department of Physics, Tsinghua University, Beijing 100084 (China); Kasliwal, Mansi M.; Neill, James D.; Kulkarni, S. R.; Quimby, Robert M. [Astronomy Department, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Ben-Ami, Sagi [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel); Bloom, Joshua S.; Cenko, S. Bradley; Nugent, Peter E. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Law, Nicholas M. [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, M5S 3H4 Ontario (Canada); Ofek, Eran O. [Benoziyo Center for Astrophysics, Faculty of Physics, Weizmann Institute of Science, Rehovot 76100 (Israel); Poznanski, Dovi, E-mail: ycao@astro.caltech.edu [School of Physics and Astronomy, Tel-Aviv University, Tel Aviv 69978 (Israel)

    2012-06-20

    We present optical light curves of 29 novae in M31 during the 2009 and 2010 observing seasons of the Palomar Transient Factory (PTF). The dynamic and rapid cadences in PTF monitoring of M31, from one day to ten minutes, provide excellent temporal coverage of nova light curves, enabling us to record the photometric evolution of M31 novae in unprecedented detail. We also detect eight of these novae in the near-ultraviolet (UV) band with the Galaxy Evolution Explorer (GALEX) satellite. Novae M31N 2009-10b and M31N 2010-11a show prominent UV emission peaking a few days prior to their optical maxima, possibly implying aspherical outbursts. Additionally, our blueshifted spectrum of the recent outburst of PT And (M31N 2010-12a) indicates that it is a recurrent nova in M31 and not a dwarf nova in the Milky Way as was previously assumed. Finally, we systematically searched for novae in all confirmed globular clusters (GCs) of M31 and found only M31N 2010-10f associated with Bol 126. The specific nova rate in the M31 GC system is thus about one per year, which is not enhanced relative to the rate outside the GC system.

  9. Binary Orbits as the Driver of Gamma-Ray Emission and Mass Ejection in Classical Novae

    Science.gov (United States)

    Chomiuk, Laura; Linford, Justin D.; Yang, Jun; O'Brien, T. J.; Paragi, Zsolt; Mioduszewski, Amy J.; Beswick, R. J.; Cheung, C. C.; Mukai, Koji; Nelson, Thomas

    2014-01-01

    Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10 (sup -4) solar masses of material at velocities exceeding 1,000 kilometers per second.However, the mechanism of mass ejection in novae is poorly understood, and could be dominated by the impulsive flash of thermonuclear energy, prolonged optically thick winds or binary interaction with the nova envelope. Classical novae are now routinely detected at giga-electronvolt gamma-ray wavelengths, suggesting that relativistic particles are accelerated by strong shocks in the ejecta. Here we report high-resolution radio imaging of the gamma-ray-emitting nova V959 Mon. We find that its ejecta were shaped by the motion of the binary system: some gas was expelled rapidly along the poles as a wind from the white dwarf, while denser material drifted out along the equatorial plane, propelled by orbital motion..At the interface between the equatorial and polar regions, we observe synchrotron emission indicative of shocks and relativistic particle acceleration, thereby pinpointing the location of gamma-ray production. Binary shaping of the nova ejecta and associated internal shocks are expected to be widespread among novae, explaining why many novae are gamma-ray emitters.

  10. MicroRNA: an Emerging Therapeutic Target and Intervention Tool

    Directory of Open Access Journals (Sweden)

    Decheng Yang

    2008-06-01

    Full Text Available MicroRNAs (miRNAs are a class of short non-coding RNAs with posttranscriptional regulatory functions. To date, more than 600 human miRNAs have been experimentally identified, and estimated to regulate more than one third of cellular messenger RNAs. Accumulating evidence has linked the dysregulated expression patterns of miRNAs to a variety of diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases and viral infections. MiRNAs provide its particular layer of network for gene regulation, thus possessing the great potential both as a novel class of therapeutic targets and as a powerful intervention tool. In this regard, synthetic RNAs that contain the binding sites of miRNA have been shown to work as a “decoy” or “miRNA sponge” to inhibit the function of specific miRNAs. On the other hand, miRNA expression vectors have been used to restore or overexpress specific miRNAs to achieve a long-term effect. Further, double-stranded miRNA mimetics for transient replacement have been experimentally validated. Endogenous precursor miRNAs have also been used as scaffolds for the induction of RNA interference. This article reviews the recent progress on this emerging technology as a powerful tool for gene regulation studies and particularly as a rationale strategy for design of therapeutics.

  11. Comparison of microRNA expression levels between initial and recurrent glioblastoma specimens.

    Science.gov (United States)

    Ilhan-Mutlu, Aysegül; Wöhrer, Adelheid; Berghoff, Anna Sophie; Widhalm, Georg; Marosi, Christine; Wagner, Ludwig; Preusser, Matthias

    2013-05-01

    Glioblastoma is the most frequent primary brain tumour in adults. Recent therapeutic advances increased patient's survival, but tumour recurrence inevitably occurs. The pathobiological mechanisms involved in glioblastoma recurrence are still unclear. MicroRNAs are small RNAs proposed o have important roles for cancer including proliferation, aggressiveness and metastases development. There exist only few data on the involvement of microRNAs in glioblastoma recurrence. We selected the following 7 microRNAs with potential relevance for glioblastoma pathobiology by means of a comprehensive literature search: microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222. We further selected 15 primary glioblastoma patients, of whom formalin fixed and paraffin embedded tissue (FFPE) of the initial and recurrence surgery were available. All patients had received first line treatment consisting of postoperative combined radiochemotherapy with temozolomide (n = 15). Non-neoplastic brain tissue samples from 3 patients with temporal lobe epilepsy served as control. The expression of the microRNAs were analysed by RT-qPCR. These were correlated with each other and with clinical parameters. All microRNAs showed detectable levels of expressions in glioblastoma group, whereas microRNA-10b was not detectable in epilepsy patients. MicroRNAs except microRNA-21 showed significantly higher levels in epilepsy patients when compared to the levels of first resection of glioblastoma. Comparison of microRNA levels between first and second resections revealed no significant change. Cox regression analyses showed no significant association of microRNA expression levels in the tumor tissue with progression free survival times. Expression levels of microRNA-10b, microRNA-21, microRNA-181b, microRNA-181c, microRNA-195, microRNA-221 and microRNA-222 do not differ significantly between initial and recurrent glioblastoma.

  12. Chandra Discovers Eruption and Pulsation in Nova Outburst

    Science.gov (United States)

    2001-09-01

    NASA's Chandra X-ray Observatory has discovered a giant outburst of X-rays and unusual cyclical pulsing from a white dwarf star that is closely orbiting another star -- the first time either of these phenomena has been seen in X-rays. The observations are helping scientists better understand the thermonuclear explosions that occur in certain binary star systems. The observations of Nova Aquilae were reported today at the "Two Years of Science with Chandra" symposium by an international team led by Sumner Starrfield of Arizona State University. "We found two important results in our Chandra observations. The first was an underlying pulsation every 40 minutes in the X-ray brightness, which we believe comes from the cyclical expansion and contraction of the outer layers of the white dwarf," said Starrfield. "The other result was an enormous flare of X-rays that lasted for 15 minutes. Nothing like this has been seen before from a nova, and we don't know how to explain it." Novas occur on a white dwarf (a star which used up all its nuclear fuel and shrank to roughly the size of the Earth) that is orbiting a normal size star. Strong gravity tides drag hydrogen gas off the normal star and onto the white dwarf, where it can take more than 100,000 years for enough hydrogen to accumulate to ignite nuclear fusion reactions. Gradually, these reactions intensify until a cosmic-sized hydrogen bomb blast results. The outer layers of the white dwarf are then blown away, producing a nova outburst that can be observed for a period of months to years as the material expands into space. "Chandra has allowed us to see deep into the gases ejected by this giant explosion and extract unparalleled information on the evolution of the white dwarf whose surface is exploding," said Jeremy Drake of the Harvard-Smithsonian Center for Astrophysics. The brightening of Nova Aquilae was first detected by optical astronomers in December 1999. "Although this star is at a distance of more than 6

  13. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... outcomes. This study uses new microdata from East Africa, incorporating test score data for over 250,000 children, to compare the likely efficacy of these two types of interventions. Endogeneity bias is addressed via fixed effects and instrumental variables techniques. Although these may not fully mitigate...

  14. Profiling of microRNAs in tumor interstitial fluid of breast tumors – a novel resource to identify biomarkers for prognostic classification and detection of cancer

    OpenAIRE

    Halvorsen, Ann Rita; Helland, Åslaug; Gromov, Pavel; Wielenga, Vera Timmermans; Talman, Maj-Lis Møller; Brünner, Nils; Sandhu, Vandana; Børresen-Dale, Anne-Lise; Gromova, Irina; Haakensen, Vilde D

    2017-01-01

    It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cross-talk that exists among cells in a tumor microenvironment. Matched tumor interstitial fluid samples (TIF, n = 60), normal interstitial fluid samples (NIF, n = 51), correspondi...

  15. Human papillomavirus 16 E5 modulates the expression of host microRNAs.

    Directory of Open Access Journals (Sweden)

    Dario Greco

    Full Text Available Human papillomavirus (HPV infection is a prerequisite of developing cervical cancer, approximately half of which are associated with HPV type 16. HPV 16 encodes three oncogenes, E5, E6, and E7, of which E5 is the least studied so far. Its roles in regulating replication and pathogenesis of HPV are not fully understood. Here we utilize high-throughput screening to coordinately investigate the effect of E5 on the expression of host protein-coding and microRNA genes. MicroRNAs form a class of 22nt long noncoding RNAs with regulatory activity. Among the altered cellular microRNAs we focus on the alteration in the expression of miR-146a, miR-203 and miR-324-5p and their target genes in a time interval of 96 hours of E5 induction. Our results indicate that HPV infection and subsequent transformation take place through complex regulatory patterns of gene expression in the host cells, part of which are regulated by the E5 protein.

  16. MicroRNAs: A Puzzling Tool in Cancer Diagnostics and Therapy.

    Science.gov (United States)

    D'Angelo, Barbara; Benedetti, Elisabetta; Cimini, Annamaria; Giordano, Antonio

    2016-11-01

    MicroRNAs (miRNAs) constitute a dominating class of small RNAs that regulate diverse cellular functions. Due the pivotal role of miRNAs in biological processes, a deregulated miRNA expression is likely involved in human cancers. MicroRNAs possess tumor suppressor capability, as well as display oncogenic characteristics. Interestingly, miRNAs exist in various biological fluids as circulating entities. Changes in the profile of circulating miRNAs are indicative of pathophysiological conditions in human cancer. This concept has led to consider circulating miRNAs valid biomarkers in cancer diagnostics. Furthermore, current research promotes the use of miRNAs as a target in cancer therapy. However, miRNAs are an evolving research field. Although miRNAs have been demonstrated to be potentially valuable tools both in cancer diagnosis and treatment, a greater effort should be made to improve our understanding of miRNAs biology. This review describes the biology of microRNAs, emphasizing on the use of miRNAs in cancer diagnostics and therapy.

  17. MicroRNA signature of the human developing pancreas

    Directory of Open Access Journals (Sweden)

    Correa-Medina Mayrin

    2010-09-01

    Full Text Available Abstract Background MicroRNAs are non-coding RNAs that regulate gene expression including differentiation and development by either inhibiting translation or inducing target degradation. The aim of this study is to determine the microRNA expression signature during human pancreatic development and to identify potential microRNA gene targets calculating correlations between the signature microRNAs and their corresponding mRNA targets, predicted by bioinformatics, in genome-wide RNA microarray study. Results The microRNA signature of human fetal pancreatic samples 10-22 weeks of gestational age (wga, was obtained by PCR-based high throughput screening with Taqman Low Density Arrays. This method led to identification of 212 microRNAs. The microRNAs were classified in 3 groups: Group number I contains 4 microRNAs with the increasing profile; II, 35 microRNAs with decreasing profile and III with 173 microRNAs, which remain unchanged. We calculated Pearson correlations between the expression profile of microRNAs and target mRNAs, predicted by TargetScan 5.1 and miRBase altgorithms, using genome-wide mRNA expression data. Group I correlated with the decreasing expression of 142 target mRNAs and Group II with the increasing expression of 876 target mRNAs. Most microRNAs correlate with multiple targets, just as mRNAs are targeted by multiple microRNAs. Among the identified targets are the genes and transcription factors known to play an essential role in pancreatic development. Conclusions We have determined specific groups of microRNAs in human fetal pancreas that change the degree of their expression throughout the development. A negative correlative analysis suggests an intertwined network of microRNAs and mRNAs collaborating with each other. This study provides information leading to potential two-way level of combinatorial control regulating gene expression through microRNAs targeting multiple mRNAs and, conversely, target mRNAs regulated in

  18. MicroRNAs in neural cell development and brain diseases.

    Science.gov (United States)

    Feng, Wei; Feng, Yue

    2011-12-01

    MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation and/or promoting mRNA degradation. Importantly, biogenesis of microRNAs displays specific temporal and spatial profiles in distinct cell and tissue types and hence affects a broad spectrum of biological functions in normal cell growth and tumor development. Recent discoveries have revealed sophisticated mechanisms that control microRNA production and homeostasis in response to developmental and extracellular signals. Moreover, a link between dysregulation of microRNAs and human brain disorders has become increasingly evident. In this review, we focus on recent advances in understanding the regulation of microRNA biogenesis and function in neuronal and glial development in the mammalian brain, and dysregulation of the microRNA pathway in neurodevelopmental and neurodegenerative diseases.

  19. Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell

    Science.gov (United States)

    Sotiropoulou, Georgia; Pampalakis, Georgios; Lianidou, Evi; Mourelatos, Zissimos

    2009-01-01

    Transformation of normal cells into malignant tumors requires the acquisition of six hallmark traits, e.g., self-sufficiency in growth signals, insensitivity to antigrowth signals and self-renewal, evasion of apoptosis, limitless replication potential, angiogenesis, invasion, and metastasis, which are common to all cancers (Hanahan and Weinberg 2000). These new cellular traits evolve from defects in major regulatory microcircuits that are fundamental for normal homeostasis. The discovery of microRNAs (miRNAs) as a new class of small non-protein-coding RNAs that control gene expression post-transcriptionally by binding to various mRNA targets suggests that these tiny RNA molecules likely act as molecular switches in the extensive regulatory web that involves thousands of transcripts. Most importantly, accumulating evidence suggests that numerous microRNAs are aberrantly expressed in human cancers. In this review, we discuss the emergent roles of microRNAs as switches that function to turn on/off known cellular microcircuits. We outline recent compelling evidence that deregulated microRNA-mediated control of cellular microcircuits cooperates with other well-established regulatory mechanisms to confer the hallmark traits of the cancer cell. Furthermore, these exciting insights into aberrant microRNA control in cancer-associated circuits may be exploited for cancer therapies that will target deregulated miRNA switches. PMID:19561119

  20. Genome-wide identification of bone metastasis-related microRNAs in lung adenocarcinoma by high-throughput sequencing.

    Directory of Open Access Journals (Sweden)

    Lin Xie

    Full Text Available BACKGROUND: MicroRNAs (miRNAs are a class of small noncoding RNAs that regulate gene expression at the post-transcriptional level. They participate in a wide variety of biological processes, including apoptosis, proliferation and metastasis. The aberrant expression of miRNAs has been found to play an important role in many cancers. RESULTS: To understand the roles of miRNAs in the bone metastasis of lung adenocarcinoma, we constructed two small RNA libraries from blood of lung adenocarcinoma patients with and without bone metastasis. High-throughput sequencing combined with differential expression analysis identified that 7 microRNAs were down-regulated and 21 microRNAs were up-regulated in lung adenocarcinoma with bone metastasis. A total of 797 target genes of the differentially expressed microRNAs were identified using a bioinformatics approach. Functional annotation analysis indicated that a number of pathways might be involved in bone metastasis, survival of the primary origin and metastatic angiogenesis of lung adenocarcinoma. These include the MAPK, Wnt, and NF-kappaB signaling pathways, as well as pathways involving the matrix metalloproteinase, cytoskeletal protein and angiogenesis factors. CONCLUSIONS: This study provides some insights into the molecular mechanisms that underlie lung adenocarcinoma development, thereby aiding the diagnosis and treatment of the disease.

  1. A LIGHT CURVE ANALYSIS OF CLASSICAL NOVAE: FREE-FREE EMISSION VERSUS PHOTOSPHERIC EMISSION

    Energy Technology Data Exchange (ETDEWEB)

    Hachisu, Izumi [Department of Earth Science and Astronomy, College of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kato, Mariko, E-mail: hachisu@ea.c.u-tokyo.ac.jp, E-mail: mariko@educ.cc.keio.ac.jp [Department of Astronomy, Keio University, Hiyoshi, Kouhoku-ku, Yokohama 223-8521 (Japan)

    2015-01-10

    We analyzed light curves of seven relatively slower novae, PW Vul, V705 Cas, GQ Mus, RR Pic, V5558 Sgr, HR Del, and V723 Cas, based on an optically thick wind theory of nova outbursts. For fast novae, free-free emission dominates the spectrum in optical bands rather than photospheric emission, and nova optical light curves follow the universal decline law. Faster novae blow stronger winds with larger mass-loss rates. Because the brightness of free-free emission depends directly on the wind mass-loss rate, faster novae show brighter optical maxima. In slower novae, however, we must take into account photospheric emission because of their lower wind mass-loss rates. We calculated three model light curves of free-free emission, photospheric emission, and their sum for various white dwarf (WD) masses with various chemical compositions of their envelopes and fitted reasonably with observational data of optical, near-IR (NIR), and UV bands. From light curve fittings of the seven novae, we estimated their absolute magnitudes, distances, and WD masses. In PW Vul and V705 Cas, free-free emission still dominates the spectrum in the optical and NIR bands. In the very slow novae, RR Pic, V5558 Sgr, HR Del, and V723 Cas, photospheric emission dominates the spectrum rather than free-free emission, which makes a deviation from the universal decline law. We have confirmed that the absolute brightnesses of our model light curves are consistent with the distance moduli of four classical novae with known distances (GK Per, V603 Aql, RR Pic, and DQ Her). We also discussed the reason why the very slow novae are about ∼1 mag brighter than the proposed maximum magnitude versus rate of decline relation.

  2. LABORATORY ANALYSIS OF PRESOLAR SILICATE STARDUST FROM A NOVA

    Energy Technology Data Exchange (ETDEWEB)

    Leitner, J.; Kodolanyi, J.; Hoppe, P. [Max Planck Institute for Chemistry, Particle Chemistry Department, Hahn-Meitner-Weg 1, D-55128 Mainz (Germany); Floss, C., E-mail: jan.leitner@mpic.de [Laboratory for Space Sciences and Physics Department, Washington University, One Brookings Drive, St. Louis, MO 63130 (United States)

    2012-08-01

    We report the major element as well as the oxygen, magnesium, and silicon isotope composition of a unique presolar silicate grain found in the fine-grained fraction of the Antarctic CR2 chondrite Graves Nunataks 95229. The grain is characterized by an extremely high {sup 17}O/{sup 16}O ratio (6.3 {+-} 0.2 Multiplication-Sign 10{sup -3}) relative to solar values, whereas its {sup 18}O/{sup 16}O ratio is solar within measurement uncertainty. It also shows enrichments in {sup 25,26}Mg and a significant excess in {sup 30}Si relative to solar system compositions, with {delta}{sup 25}Mg = 79 {+-} 21 per mille , {delta}{sup 26}Mg = 70 {+-} 20 per mille , and {delta}{sup 30}Si = 379 {+-} 92 per mille . This isotopic composition is consistent with an origin in the ejecta of a {approx}1.3-1.4 M{sub Sun} ONe nova with large contributions of material from a main-sequence companion star of roughly solar metallicity. However, many details of the stellar source remain undetermined, owing to the uncertainties of current nova nucleosynthesis models. Auger electron spectroscopic analyses identify O, Mg, Si, and Fe as the grain's major constituents. Its (Mg+Fe)/Si atomic ratios are lower than that of olivine and correspond on average to Fe-Mg-pyroxene. A complex texture and heterogeneous major element distribution within the grain attest to condensation under non-equilibrium conditions, which is consistent with the proposed nova origin.

  3. Novae as Tevatrons: prospects for CTA and IceCube

    Science.gov (United States)

    Metzger, B. D.; Caprioli, D.; Vurm, I.; Beloborodov, A. M.; Bartos, I.; Vlasov, A.

    2016-04-01

    The discovery of novae as sources of ˜0.1-1 GeV gamma-rays highlights the key role of shocks and relativistic particle acceleration in these transient systems. Although there is evidence for a spectral cut-off above energies ˜1-100 GeV at particular epochs in some novae, the maximum particle energy achieved in these accelerators has remained an open question. The high densities of the nova ejecta (˜10 orders of magnitude larger than in supernova remnants) render the gas far upstream of the shock neutral and shielded from ionizing radiation. The amplification of the magnetic field needed for diffusive shock acceleration requires ionized gas, thus confining the acceleration process to a narrow photoionized layer immediately ahead of the shock. Based on the growth rate of the hybrid non-resonant cosmic ray current-driven instability (considering also ion-neutral damping), we quantify the maximum particle energy, Emax, across the range of shock velocities and upstream densities of interest. We find values of Emax ˜ 10 GeV-10 TeV, which are broadly consistent with the inferred spectral cut-offs, but which could also in principle lead to emission extending to ≳ 100 GeV accessible to atmosphere Cherenkov telescopes, such as the Cherenkov Telescope Array (CTA). Detecting TeV neutrinos with IceCube is more challenging, although the prospects are improved for a nearby event (≲ kpc) or if the shock power during the earliest, densest phases of the outburst is higher than implied by the GeV light curves, due to downscattering of the gamma-rays within the ejecta.

  4. Recurrent Novae as a progenitor system of Type Ia Supernovae

    Science.gov (United States)

    Hachisu, Izumi; Kato, Mariko

    2002-11-01

    Theoretical light curves of 8 recurrent novae in outburst are modeled to obtain various physical parameters. Light curve calculation includes reflection effects of the companion star and the accretion disk by the photosphere of the white dwarf (WD). We also include a radiation-induced warping instability of the accretion disk in order to reproduce the second peak of T CrB outbursts. The early visual light curves are well reproduced with an expanded WD photosphere of a thermonuclear runaway model on a very massive WD close to the Chandrasekhar mass limit, i.e., MWD = 1.35 - 1.37 Msolar except for CI Aql. The white dwarf mass of CI Aql is estimated to be MWD = 1.2 +/- 0.05 Msolar. Optically thick winds, which blow from the WDs during the outbursts, play a key role in determining the nova duration and the speed of decline because the wind quickly reduces the envelope mass on the WD. Each envelope mass at the optical maximum is estimated, which indicates an average mass accretion rate on to the WDs during the quiescent phase before the last outburst. Although a large part of the envelope mass is blown in the wind, each WD can retain a substantial part of the envelope mass after hydrogen burning ends. Thus, we have obtained net mass-increasing rates of the WDs. These obtained values strongly indicate that the WDs in the recurrent novae have now grown up to near the Chandrasekhar mass limit and will soon explode as a Type Ia supernova if the WDs consist of carbon and oxygen. We have also clarified the reason why only T CrB shows a secondary maximum.

  5. Hydrodynamic Studies of the Evolution of Recurrent, Symbiotic, and Dwarf Novae: The White Dwarf Components are Growing in Mass

    CERN Document Server

    Starrfield, S; Iliadis, C; Hix, W R; Arnett, W D; Meakin, C; Sparks, W M

    2012-01-01

    Symbiotic binaries are systems containing white dwarfs (WDs) and red giants. Symbiotic novae are those systems in which thermonuclear eruptions occur on the WD components. These are to be distinguished from events driven by accretion disk instabilities analogous to dwarf novae eruptions in cataclysmic variable outbursts. Another class of symbiotic systems are those in which the WD is extremely luminous and it seems likely that quiescent nuclear burning is ongoing on the accreting WD. A fundamental question is the secular evolution of the WD. Do the repeated outbursts or quiescent burning in these accreting systems cause the WD to gain or lose mass? If it is gaining mass, can it eventually reach the Chandrasekhar Limit and become a supernova (a SN Ia if it can hide the hydrogen and helium in the system)? In order to better understand these systems, we have begun a new study of the evolution of Thermonuclear Runaways (TNRs) in the accreted envelopes of WDs using a variety of initial WD masses, luminosities and ...

  6. MicroRNA silencing in primates: towards development of novel therapeutics

    DEFF Research Database (Denmark)

    Petri, Andreas; Lindow, Morten; Kauppinen, Sakari

    2009-01-01

    MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic ...... intervention. Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such compounds in the development of miRNA-based cancer therapeutics....

  7. Export of microRNAs and microRNA-protective protein by mammalian cells

    OpenAIRE

    Wang, Kai; Zhang, Shile; Weber, Jessica; Baxter, David; Galas, David J.

    2010-01-01

    The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has triggered an explosion of research activities, but has left many unanswered questions about how this regulation functions and how it is integrated with other regulatory mechanisms. A number of miRNAs have been found to be present in plasma and other body fluids of humans and mice in surprisingly high concentrations. This observation was unexpected in two respects: first, the fact that these molecules are p...

  8. Micro-RNA profiling in kidney and bladder cancers.

    Science.gov (United States)

    Gottardo, Fedra; Liu, Chang Gong; Ferracin, Manuela; Calin, George A; Fassan, Matteo; Bassi, Pierfrancesco; Sevignani, Cinzia; Byrne, Dolores; Negrini, Massimo; Pagano, Francesco; Gomella, Leonard G; Croce, Carlo M; Baffa, Raffaele

    2007-01-01

    Micro-RNAs are a group of small noncoding RNAs with modulator activity of gene expression. Recently, micro-RNA genes were found abnormally expressed in several types of cancers. To study the role of the micro-RNAs in human kidney and bladder cancer, we analyzed the expression profile of 245 micro-RNAs in kidney and bladder primary tumors. A total of 27 kidney specimens (20 carcinomas, 4 benign renal tumors, and 3 normal parenchyma) and 27 bladder specimens (25 urothelial carcinomas and 2 normal mucosa) were included in the study. Total RNA was used for hybridization on an oligonucleotide microchip for micro-RNA profiling developed in our laboratories. This microchip contains 368 probes in triplicate, corresponding to 245 human and mouse micro-RNA genes. A set of 4 human micro-RNAs (miR-28, miR-185, miR-27, and let-7f-2) were found significantly up-regulated in renal cell carcinoma (P micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P micro-RNA expression across various stages, whereas with increasing tumor-nodes-metastasis staging in bladder cancer, miR-26b showed a moderate decreasing trend (P = 0.082). Our results show that different micro-RNAs are deregulated in kidney and bladder cancer, suggesting the involvement of these genes in the development and progression of these malignancies. Further studies are needed to clarify the role of micro-RNAs in neoplastic transformation and to test the potential clinical usefulness of micro-RNAs microarrays as diagnostic and prognostic tool.

  9. Discovery of an Apparent Nova in M81

    Science.gov (United States)

    Hornoch, K.; Vaduvescu, O.; Gonzalez, A.

    2013-04-01

    We report the discovery of an apparent nova in the M81 galaxy on a co-added 2000-s narrow-band H-alpha CCD image taken with the 2.5-m Isaac Newton Telescope (INT) + WFC at La Palma in ~1.4" seeing on Apr. 5.946 UT. The new object is visible on individual 400-s frames and well visible on the co-added image (see the finding chart linked below), but is not present on numerous narrow-band H-alpha archival images from the INT down to limiting magnitude as faint as H-alpha = 21.7.

  10. Equation of State measurements of hydrogen isotopes on Nova

    Energy Technology Data Exchange (ETDEWEB)

    Collins, G. W., LLNL

    1997-11-01

    High intensity lasers can be used to perform measurements of materials at extremely high pressures if certain experimental issues can be overcome. We have addressed those issues and used the Nova laser to shock-compress liquid deuterium and obtain measurements of density and pressure on the principal Hugoniot at pressures from 300 kbar to more than 2 Mbar. The data are compared with a number of equation of state models. The data indicate that the effect of molecular dissociation of the deuterium into a monatomic phase may have a significant impact on the equation of state near 1 Mbar.

  11. A nova mobilidade populacional: circulação integral

    OpenAIRE

    Lopes, Policarpo

    1998-01-01

    A mundialização crescente dos mercados, da informação, do turismo e da chamada circulação integral veio dar uma nova amplitude e consistência ao regime de mobilidade generalizada à escala planetária. Os movimentos de população dele emergentes alimentam todo um sistema de transacções particularmente intenso e diversificado entre montante e jusante das populações em mobilidade. Observemos a evolução destes movimentos, na sua pluriformidade, fluxos e(i)migratórios e movimentos turísticos, a part...

  12. Miroljubivi uspon – nova kineska vanjskopolitička teorija

    OpenAIRE

    Baković, Ozren

    2004-01-01

    Kao izraz težnje za osuvremenjivanjem kineske vanjske politike u promijenjenim globalnim uvjetima na početku 21. stoljeća, pojavila se nova službena kineska vanjskopolitička teorija – teorija “miroljubivog uspona”. Nakon što je naviše kinesko rukovodstvo usvojilo teoriju, ona se sad nastoji objasniti međunarodnoj javnosti. Osnovna je postavka teorije “miroljubivog uspona” da snažan dugoročni rast kineskoga gospodarstva i afirmacija Kine u međunarodnim odnosima nije ni regionalna ni globalna p...

  13. Corpos e Corporeidade no Universo da Nova Era no Brasil

    OpenAIRE

    Amurabi Oliveira

    2012-01-01

    O presente trabalho busca explorar a dimensão corpórea enquanto central para a compreensão do fenômeno religioso, em especial do universo Nova Era – NE, em nossa interpretação o corpo apresenta-se enquanto estrutura estruturada estruturante que possibilita aos sujeitos vivenciar e interpretar o mundo, neste sentido, a experiência de imersão e de vivência das práticas da NE são, essencialmente, experiências corpóreas. No decorrer deste trabalho buscaremos dar destaque aos aspect...

  14. CCD Photometry of Dwarf Nova AL Com in Superoutburst

    OpenAIRE

    Pych, W.; Olech, A.

    1995-01-01

    We report a CCD optical photometry of a dwarf nova AL Com in superoutburst. Before superhumps occurred the light curve was highly variable with dominant periods about 41 minutes and 81.5 minutes for different nights. The period of observed superhumps is 82.5 minutes and seems to be stable. The first harmonic of the basic period is also present. We detected a weak signal corresponding to period 78.1 minutes. One of the periods 78.1 or 81.5 is suspected to be a possible signature of orbital mot...

  15. Brief outbursts in the dwarf nova V1316 Cygni

    CERN Document Server

    Shears, J; Poyner, G; Shears, Jeremy; Boyd, David; Poyner, Gary

    2006-01-01

    Several brief outbursts were detected in the dwarf nova V1316 Cyg during 2005. These events have an average amplitude of 1.4 magnitude and a duration of <1 to 2 days. Whilst no outburst period could be confirmed, the shortest period between detected events is 10 days. These curious brief outbursts appear to be the normal pattern of behaviour for this system. They are of smaller amplitude and shorter duration than normal outbursts previously reported in this star. V1316 Cyg appears to be a very unusual system and we suggest that further observations by both amateur and professional astronomers could yield important information about the underlying mechanism.

  16. Guanosina : uma nova abordagem do sistema purinérgico

    OpenAIRE

    Felix Alexandre Antunes Soares

    2005-01-01

    Durante as últimas décadas os estudos do sistema purinérgico concentraram seu foco de atenção nas ações dos derivados da adenina (como adenosina e o ATP). Seus efeitos, receptores, agonistas e antagonistas encontram-se muito bem estabelecidos dentro do sistema nervoso central. Os resultados obtidos com os diversos estudos dos derivados da guanina trazem uma nova perspectiva para o estudo do sistema purinérgico. Os nucleotídeos derivados da guanina são classicamente associados ao sistema de tr...

  17. Novas tecnologias aplicadas às embalagens de alimentos

    OpenAIRE

    Flávia De Floriani Pozza Rebello

    2009-01-01

    Com o desenvolvimento da indústria de alimentos, as embalagens têm se aperfeiçoado, indo além de sua função básica de proteger o alimento contra danos mecânicos e contaminações químicas e microbiológicas. Elas têm cada vez mais desempenhando papel de destaque, contribuindo ativamente para a venda de um produto. Assim, as indústrias de embalagens têm procurado atender aos consumidores mais exigentes e juntamente aos centros de pesquisa e universidades, têm investido mais em estudos de novas te...

  18. Psicofarmacogenética: uma nova abordagem terapêutica

    Directory of Open Access Journals (Sweden)

    Vallada Filho Homero Pinto

    1999-01-01

    Full Text Available A psicofarmacogenética é uma nova área de investigação derivada da psicofarmacologia e da genética. Esta disciplina procura identificar genes de suscetibilidade associados a diferentes padrões de resposta terapêutica e/ou ao variado grau de efeitos colaterais dos psicofármacos. O presente artigo discorrerá, após um breve histórico, sobre alguns exemplos de variantes genéticas relacionadas com a resposta terapêutica de antipsicóticos e antidepressivos.

  19. Orbital period determination in an eclipsing dwarf nova HT Cas

    Science.gov (United States)

    Bąkowska, Karolina; Olech, Arkadiusz

    2014-09-01

    HT Cassiopeiae was discovered over seventy years ago (Hoffmeister 1943). Unfortunately, for 35 years this object did not receive any attention, until the eclipses of HT Cas were observed by Bond. After a first analysis, Patterson (1981) called HT Cas "a Rosetta stone among dwarf novae". Since then, the literature on this star is still growing, reaching several dozens of publications. We present an orbital period determination of HT Cas during the November 2010 super-outburst, but also during a longer time span, to check its stability.

  20. Nova control system: goals, architecture, and system design

    Energy Technology Data Exchange (ETDEWEB)

    Suski, G.J.; Duffy, J.M.; Gritton, D.G.; Holloway, F.W.; Krammen, J.R.; Ozarski, R.G.; Severyn, J.R.; Van Arsdall, P.J.

    1982-05-19

    The control system for the Nova laser must operate reliably in a harsh pulse power environment and satisfy requirements of technical functionality, flexibility, maintainability and operability. It is composed of four fundamental subsystems: Power Conditioning, Alignment, Laser Diagnostics, and Target Diagnostics, together with a fifth, unifying subsystem called Central Controls. The system architecture utilizes a collection of distributed microcomputers, minicomputers, and components interconnected through high speed fiber optic communications systems. The design objectives, development strategy and architecture of the overall control system and each of its four fundamental subsystems are discussed. Specific hardware and software developments in several areas are also covered.

  1. A nova alfabetização por (em) computador

    OpenAIRE

    Reinking, David

    2013-01-01

    Neste artigo o autor apresenta argumentos para ampliar os conceitos de alfabetização no intuito de dar espaço para a escrita e a leitura de textos eletrônicos. Relaciona quatro características dos texto eletrônicos que subjazem à nova alfabetização por(em) computador. Os textos eletrônicos (a) facilitam uma interação entre leitores e textos. (b) podem influenciar a leitura pelo fato de limitar o acesso ao texto, (c) podem apresentar uma estrutura diferente do que os textos impressos, e (d) em...

  2. MicroRNA expression profiling of the porcine developing brain

    DEFF Research Database (Denmark)

    Podolska, Agnieszka; Kaczkowski, Bogumil; Busk, Peter Kamp;

    2011-01-01

    MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most micro...... and the growth curve when compared to humans. Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain....

  3. MicroRNAs: Emerging Novel Clinical Biomarkers for Hepatocellular Carcinomas

    Directory of Open Access Journals (Sweden)

    Sumadi Lukman Anwar

    2015-08-01

    Full Text Available The discovery of small non-coding RNAs known as microRNAs has refined our view of the complexity of gene expression regulation. In hepatocellular carcinoma (HCC, the fifth most frequent cancer and the third leading cause of cancer death worldwide, dysregulation of microRNAs has been implicated in all aspects of hepatocarcinogenesis. In addition, alterations of microRNA expression have also been reported in non-cancerous liver diseases including chronic hepatitis and liver cirrhosis. MicroRNAs have been proposed as clinically useful diagnostic biomarkers to differentiate HCC from different liver pathologies and healthy controls. Unique patterns of microRNA expression have also been implicated as biomarkers for prognosis as well as to predict and monitor therapeutic responses in HCC. Since dysregulation has been detected in various specimens including primary liver cancer tissues, serum, plasma, and urine, microRNAs represent novel non-invasive markers for HCC screening and predicting therapeutic responses. However, despite a significant number of studies, a consensus on which microRNA panels, sample types, and methodologies for microRNA expression analysis have to be used has not yet been established. This review focuses on potential values, benefits, and limitations of microRNAs as new clinical markers for diagnosis, prognosis, prediction, and therapeutic monitoring in HCC.

  4. O Transito e o Turismo na Cidade de caldas Novas - GO / TRAFFIC AND TOURISM IN THE CALDAS NOVAS CITY - BRAZIL

    Directory of Open Access Journals (Sweden)

    Norma Urban Gomes

    2010-05-01

    Full Text Available Resumo: Este trabalho tem como objetivo, mostrar a relação intrínseca entre o trânsito e o turismo na cidade de Caldas Novas – GO. Deste modo, para estudarmos o trânsito e seus elementos, bem como todos os fatores positivos e negativos do mesmo na cidade teremos necessariamente que falar a respeito do turismo, pois é partir dessa premissa que se molda a questão da Geografia dos Transportes em Caldas Novas,cidade esta que se destaca pelo apelo turístico de suas águas termais. A Geografia se preocupa com o inter-relacionamento ambiental e humano em um contexto espacial, e Geografia dos Transportes é o estudo dos sistemas de transportes e seus impactos espaciais. Os meios de transporte são essenciais em uma cidade turística, pois o fluxo de pessoas, bens e serviços dependem substancialmente da condição de circulação. Esse trabalho justifica-se pela necessidade de compreender e avaliar a situação do trânsito na cidade de Caldas Novas nos períodos de alta temporada, quando a cidade sofre intensa movimentação turística,causando um grande acumulo de veículos e pessoas nas vias de circulação. Isso dificulta além obviamente da circulação das pessoas como a circulação de bens e serviços essenciais para que a atividade turística se desenvolva satisfatoriamente. O estudo dos transportes é, sobretudo, multidisciplinar por natureza, e algumas vezes também interdisciplinar.

  5. Library Cooperation at the NOVA University--the Nordic University in Agriculture, Forestry and Veterinary Medicine.

    Science.gov (United States)

    Myllys, Heli

    The Nordic University in Agriculture, Forestry and Veterinary Medicine--the NOVA University-was established in 1995 to increase the cooperation between the Nordic agricultural universities. The NOVA libraries of the seven institutions and facilities involved wanted to show that they are a very useful partner in launching new ideas. They have the…

  6. A Light Curve Analysis of Classical Novae: Free-free Emission vs. Photospheric Emission

    CERN Document Server

    Hachisu, Izumi

    2014-01-01

    We analyzed light curves of seven relatively slower novae, PW Vul, V705 Cas, GQ Mus, RR Pic, V5558 Sgr, HR Del, and V723 Cas, based on an optically thick wind theory of nova outbursts. For fast novae, free-free emission dominates the spectrum in optical bands rather than photospheric emission and nova optical light curves follow the universal decline law. Faster novae blow stronger winds with larger mass loss rates. Since the brightness of free-free emission depends directly on the wind mass loss rate, faster novae show brighter optical maxima. In slower novae, however, we must take into account photospheric emission because of their lower wind mass loss rates. We calculated three model light curves of free-free emission, photospheric emission, and the sum of them for various WD masses with various chemical compositions of their envelopes, and fitted reasonably with observational data of optical, near-IR (NIR), and UV bands. From light curve fittings of the seven novae, we estimated their absolute magnitudes,...

  7. 大豆microRNA基因GmMIR160A负调控植物叶片衰老进程%GmMIR1 60A,a class of soybean microRNA gene, negatively regulates progress of leaf senescence

    Institute of Scientific and Technical Information of China (English)

    李小平; 曾庆发; 张根生; 赵娟

    2015-01-01

    Leaf senescence is known to be a genetic programmed process regulated by the interior and/or exterior fac-tors.Plant hormones including cytokinins,ethylene and auxin directly or indirectly regulate leaf senescence as pivotal interior factors through their redistribution and local concentration gradient by long and/or short distance transport. The molecular genetics study has shown that the cytokinins work as a repressor and the ethylene as a positive regula-tor respectively during the processes of leaf senescence.However,the molecular mechanism of auxin involved in regu-lating leaf senescence is largely unknown.The mature microRNAs are a kind of small and short double-strand RNA molecules with 21-23 bp length,which are first transcripted from mircroRNA (miRNA)genes and then processed by the special enzymes.These small RNAs are proved to be involved in many plant growth and development proces-ses by matching their specific targets in an inaccuracy manner.However,there is no evidence that the specific microR-NA could regulate plant leaf senescence in soybean so far.Soybean is a both oil crop and the classical seed-setting de-pendent aging species.To uncover the molecular mechanism of soybean leaf senescence should have both the impor-tant scientific significance and the profound application value in the future.In this report,we used real-time fluores-cence quantitative PCR (qPCR)approach to explore the expression pattern ofGmMIR160A gene during the develop-ment of the first trifoliage soybean leaves.We found that the messenger RNA of GmMIR160A was rapidly induced by both exogenous applied auxin and darkness treatment,suggesting that this gene could be both an immediate auxin-responsive gene and leaf senescence-associated gene.To further investigate the role of GmMIR160A gene during the soybean leaf development,the binary vector over-expressing GmMIR160A induced by glucocorticoid-like chemical, dexamethasone (DEX),was constructed and then transformed into wild

  8. Class distinction

    Science.gov (United States)

    White, M. Catherine

    Typical 101 courses discourage many students from pursuing higher level science and math courses. Introductory classes in science and math serve largely as a filter, screening out all but the most promising students, and leaving the majority of college graduates—including most prospective teachers—with little understanding of how science works, according to a study conducted for the National Science Foundation. Because few teachers, particularly at the elementary level, experience any collegiate science teaching that stresses skills of inquiry and investigation, they simply never learn to use those methods in their teaching, the report states.

  9. Novas Cartas Portuguesas: The Making of a Reputation

    Directory of Open Access Journals (Sweden)

    Ana Margarida Dias Martins

    2012-05-01

    Full Text Available Novas Cartas Portuguesas (New Portuguese Letters, co-authored by Maria Isabel Barreno, Maria Teresa Horta, and Maria Velho da Costa, was banned in 1972 in Portugal for exploring sensitive issues such as women's oppression under the Catholic patriarchy. Given that police action against the authors soon became the focus of an international feminist protest in 1972-73, existing discussions of the book's reception often focus almost exclusively on what may be called its political life. I propose to approach the book from a new angle, with the purpose of uncovering its theoretical dimension as a literary-critical text that may have played an important role in helping to shape feminist intellectual directions of the 1970s. Specifically, I analyze how a general insistence on the political life of Novas Cartas contributed to marginalizing the work on a theoretical level, transforming it into a "strange" (Ahmed textual body out of place. In a manner similar to what would later happen to the Brazilian writer Clarice Lispector as a result of Hélène Cixous's feminist sponsorship of her work, this marginalization helped define the boundaries of "international feminism" as opposed to "Portuguese anti-fascism," according to a conception of the Lusophone cultural sphere as an anachronistic feminine space for political action, entirely disconnected from the centers where feminist theory is made.

  10. The unusual Nova Cygni 2006 (V2362 Cyg)

    CERN Document Server

    Kimeswenger, S; Knapp, A; Schafer, J; Unterguggenberger, S; Weiss, S

    2008-01-01

    Context: Optical nova lightcurves often have structures, such as rapid declines and recoveries, due to nebular or dusty phases of the ejecta. Nova Cygni 2006 (V2362 Cyg) underwent an unusual brightening after an early rapid decline. The shape of the lightcurve can be compared to that of V1493 Aql, but the whole event in that case was not as bright and only lasted a couple of weeks. V2362 Cyg had a moderately fast decline of t_2 = 9.0 before rebrightening, which lasted 250 days after maximum. Aims: We present an analysis of our own spectroscopic investigations in combination with AAVSO photometric data covering the whole rebrightening phase until the return to the final decline. Methods: We used the medium resolution spectroscopy obtained in ten nights over a period of 79 nights to investigate the change of the velocity structure of the ejecta. The publicly available AAVSO photometry was used to analyze the overall properties and the energy of the brightening. Results: Although the behavior of the main outburs...

  11. Mixing in classical novae: a 2-D sensitivity study

    CERN Document Server

    Casanova, Jordi; Garcia-Berro, Enrique; Calder, Alan; Shore, Steven N

    2010-01-01

    Classical novae are explosive phenomena that take place in stellar binary systems. They are powered by mass transfer from a low-mass, main sequence star onto a white dwarf. The material piles up under degenerate conditions and a thermonuclear runaway ensues. The energy released by the suite of nuclear processes operating at the envelope heats the material up to peak temperatures of ~ (1 - 4) \\times 108 K. During these events, about 10-4 - 10-5 M\\odot, enriched in CNO and other intermediate-mass elements, are ejected into the interstellar medium. To account for the gross observational properties of classical novae (in particular, a metallicity enhancement in the ejecta above solar values), numerical models assume mixing between the (solar-like) material transferred from the companion and the outermost layers (CO- or ONe-rich) of the underlying white dwarf. The nature of the mixing mechanism that operates at the core-envelope interface has puzzled stellar modelers for about 40 years. Here we investigate the rol...

  12. The formation of Cataclysmic Variables: the influence of nova eruptions

    CERN Document Server

    Nelemans, G; Repetto, S; Toonen, S; Phinney, E S

    2015-01-01

    The theoretical and observed populations of pre-cataclysmic variables (pre-CVs) are dominated by systems with low-mass white dwarfs (WDs), while the WD masses in CVs are typically high. In addition, the space density of CVs is found to be significantly lower than theoretical models. We investigate the influence of nova outbursts on the formation and (initial) evolution of CVs. In particular, we calculate the stability of the mass transfer in case all the material accreted on the WD is lost in classical novae, and part of the energy to eject the material comes from a common-envelope like interaction with the companion. In addition, we study the effect of an asymmetry in the mass ejection, that may lead to small eccentricities in the orbit. We find that a common-envelope like ejection significantly decreases the stability of the mass transfer, in particular for low-mass WD. Similarly, the influence of asymmetric mass loss can be important for short-period systems and even more so for low-mass WD, but likely dis...

  13. IX Draconis - a curious ER UMa-type dwarf nova

    CERN Document Server

    Otulakowska-Hypka, M; de Miguel, E; Rutkowski, A; Koff, R; B\\kakowska, K

    2012-01-01

    We report results of an extensive world-wide observing campaign devoted to a very active dwarf nova star - IX Draconis. We investigated photometric behaviour of the system to derive its basic outburst properties and understand peculiarities of IX Dra as well as other active cataclysmic variables, in particular dwarf novae of the ER Uma-type. In order to measure fundamental parameters of the system, we carried out analyses of the light curve, O-C diagram, and power spectra. During over two months of observations we detected two superoutbursts and several normal outbursts. The V magnitude of the star varied in the range 14.6 - 18.2 mag. Superoutbursts occur regularly with the supercycle length of 58.5+/-0.5 d. When analysing data over the past 20 years, we found that the supercycle length is increasing at a rate of P_dot = 1.8 * 10^{-3}. Normal outbursts appear to be irregular, with typical occurrence times in the range 3.1 - 4.1 d. We detected a double-peaked structure of superhumps during superoutburst, with ...

  14. A remarkable recurrent nova in M31 - The optical observations

    CERN Document Server

    Darnley, M J; Bode, M F; Henze, M; Ness, J -U; Shafter, A W; Hornoch, K; Votruba, V

    2014-01-01

    Context. In late November 2013 a fourth outburst in five years of the M31 recurrent nova M31N 2008-12a was announced. Aims. In this Letter we address the optical lightcurve and progenitor system of M31N 2008-12a. Methods. Optical imaging data of the 2013 outburst from the Liverpool Telescope, La Palma, and Danish 1.54m Telescope, La Silla, and archival Hubble Space Telescope near-IR, optical and near-UV data are astrometrically and photometrically analysed. Results. Photometry of the 2013 outburst, combined with the previous three, enabled construction of a template lightcurve of a very fast nova (t2 (V) ~4 days). The archival data allowed recovery of the progenitor system in optical and near-UV data, indicating a red-giant secondary with bright accretion disk, or alternatively a system with a sub-giant secondary but dominated by a disk. Conclusions. The outbursts of M31N 2008-12a, plus a number of historic X-ray detections, indicate a unique system with a recurrence timescale of ~1 year. This implies the pre...

  15. The NOvA νe Appearance Analysis

    Science.gov (United States)

    Colo, Marco; NOvA Collaboration

    2017-01-01

    Since neutrino oscillations were first detected, oscillation experiments have managed to measure most of the parameters that govern this phenomenon. Major unknowns remain: the mass ordering - whether ν3 is the heaviest neutrino state, or the lightest; CP Violation - whether neutrino oscillation violate CP symmetry, and, if so, how big is the CP-violating phase δCP; and, the θ23 octant - whether the value of θ23 resides in the lower octant (θ23 45°) or is exactly maximal (θ23 =45°). NOvA, with its 810 km baseline, the longest of any currently running experiment, and its capability to switch between a νμ source and a νμ source, is extremely well positioned to address these questions. In this talk, I will discuss the νe appearance analysis in NOvA: I will illustrate the analysis method, discuss the results that we have obtained in the latest round of analysis, and talk about what we expect from future runs.

  16. A study of the shell of Nova V2659 Cyg

    Science.gov (United States)

    Tarasova, T. N.

    2016-12-01

    Results of a study of the shell of Nova V2659 Cyg based on spectrophotometric observations carried out over a year and a half after its eruption are presented. The physical conditions in the nova shell have been studied. The electron temperature (9000 K) and density (5 × 106 cm-3) in the nebular stage have been estimated, together with the abundances of helium, oxygen, nitrogen, neon, argon, and iron. The abundances of nitrogen, oxygen, neon, and argon are enhanced relative to the solar values. The relative abundances are [N/H] = 2.26 ± 0.25 dex, [O/H] = 1.66 ± 0.35 dex, [Ne/H] = 0.78 ± 0.25 dex, and [Ar/H] = 0.32 ± 0.38 dex. The estimated mass of oxygen and total mass of the emitting shell are ≈1 × 10-4 M ⊙ and ≈3 × 10-4 M ⊙, respectively. In the period of chaotic brightness oscillations, the maximum velocity of the shell expansion derived from the radial velocities of the absorption components of the HI and FeII line profiles increased by ≈400 km/s 41 days after the maximum, and by ≈200 km/s 101 days after the maximum, reaching 1600 km/s in both cases.

  17. Optical spectroscopy of the dwarf nova U Geminorum

    CERN Document Server

    Morales-Rueda, T R

    2006-01-01

    U Gem is unique in having a direct measurement of K1 = 107 +- 2 km/s, Long et al. 1999). We present high-resolution optical spectra of the dwarf nova U Gem in quiescence taken to test the accuracy to which the HST value can be recovered from optical data. We find that, even with data of very high S/N we cannot recover Long et al.'s value to better than about 20% by any method. Contamination by neighbouring emission lines seems a likely culprit. Our data reveal a number of new features: Doppler tomograms show emission at low velocity, close to the centre of mass, and a transient, narrow absorption feature is seen in the Balmer lines near the line centres at the time of eclipse. We suggest that stellar prominences, as previously invoked for the dwarf novae IP Peg and SS Cyg in outburst, may explain both of these features. The He II 4686.75 A line emission is dominated by the gas stream/disc impact region. Two distinct spots are seen in Doppler maps, the first being very narrow and showing a velocity close to th...

  18. Pan-chromatic observations of the remarkable nova LMC 2012

    CERN Document Server

    Schwarz, Greg J; Page, Kim L; Osborne, Julian P; Beardmore, Andrew P; Walter, Frederick M; Bode, Michael F; Drake, Jeremy J; Ness, Jan-Uwe; Starrfield, Sumner; Van Rossum, Daniel R; Woodward, Charles E

    2014-01-01

    We present the results of an intensive multiwavelength campaign on nova LMC 2012. This nova evolved very rapidly in all observed wavelengths. The time to fall two magnitudes in the V band was only 2 days. In X-rays the super soft phase began 13$\\pm$5 days after discovery and ended around day 50 after discovery. During the super soft phase, the \\Swift/XRT and \\Chandra\\ spectra were consistent with the underlying white dwarf being very hot, $\\sim$ 1 MK, and luminous, $\\sim$ 10$^{38}$ erg s$^{-1}$. The UV, optical, and near-IR photometry showed a periodic variation after the initial and rapid fading had ended. Timing analysis revealed a consistent 19.24$\\pm$0.03 hr period in all UV, optical, and near-IR bands with amplitudes of $\\sim$ 0.3 magnitudes which we associate with the orbital period of the central binary. No periods were detected in the corresponding X-ray data sets. A moderately high inclination system, $i$ = 60$\\pm$10$^{\\arcdeg}$, was inferred from the early optical emission lines. The {\\it HST}/STIS ...

  19. Guerra do Golfo: a crise da nova ordem mundial

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2004-06-01

    Full Text Available Este artigo, tomando como ponto de partida as Guerras do Golfo, traça o perfil da nova ordem mundial formada com a derrocada da União Soviética e o fim da Guerra Fria, e a ascensão dos Estados Unidos como única superpotência no século XXI. O autor também afirma que a nova ordem mundial, proclamada com vistas à promoção permanente do desenvolvimento e da paz, residiria no binômio político-econômico da democracia neoliberal.This article, taking as a starting point the Gulf Wars, traces the profile of the new world order that took shape with the end of Cold War and the Soviet Union, and the raise of the United States as the major power in the 21st century. The author also affirms that the new world order, proclaimed in order to promote permanent development and peace, combines the economic-politic binomial of the neo-liberal democracy.

  20. Uma nova cidade para as águas urbanas

    Directory of Open Access Journals (Sweden)

    Renato Luiz Sobral Anelli

    2015-08-01

    Full Text Available O artigo apresenta os paradigmas que podem ser revistos para que no futuro não se repita a grave crise de abastecimento de água nas grandes regiões metropolitanas da macrometrópole paulista. Inicia por um breve histórico do desenvolvimento urbano da Região Metropolitana de São Paulo e sua relação com os recursos hídricos, destacando os planos e projetos que servem de exemplos para uma nova concepção urbanística para as águas urbanas. Destaca as oportunidades abertas pela revisão do aparato de ordenação urbana de São Paulo, iniciada pelo novo Plano Diretor Estratégico, no qual estão propostos instrumentos de planejamento e gestão capazes de amparar uma nova forma de cidade para as águas urbanas.

  1. The astronomizings of Dr. Anderson and the curious case of his disappearing nova

    CERN Document Server

    Shears, Jeremy

    2012-01-01

    Dr. Thomas David Anderson (1853-1932) was a Scottish amateur astronomer famed for his discovery of two bright novae: Nova Aurigae 1891 and Nova Persei 1901. He also discovered more than 50 variable stars as well as making independent discoveries of Nova Aquilae 1918 and comet 17P/Holmes in 1892. At the age of seventy, in 1923, he reported his discovery of a further nova, this time in Cygnus. This was set to be the culmination of a lifetime devoted to scanning the night sky, but unfortunately no one was able to confirm it. This paper discusses Anderson's life leading up to the discovery and considers whether it was real or illusory.

  2. MicroRNAs, epigenetics and disease

    DEFF Research Database (Denmark)

    Silahtaroglu, Asli; Stenvang, Jan

    2010-01-01

    Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules...... which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation......, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other...

  3. Scleral micro-RNA signatures in adult and fetal eyes.

    Science.gov (United States)

    Metlapally, Ravikanth; Gonzalez, Pedro; Hawthorne, Felicia A; Tran-Viet, Khanh-Nhat; Wildsoet, Christine F; Young, Terri L

    2013-01-01

    In human eyes, ocular enlargement/growth reflects active extracellular matrix remodeling of the outer scleral shell. Micro-RNAs are small non-coding RNAs that regulate gene expression by base pairing with target sequences. They serve as nodes of signaling networks. We hypothesized that the sclera, like most tissues, expresses micro-RNAs, some of which modulate genes regulating ocular growth. In this study, the scleral micro-RNA expression profile of rapidly growing human fetal eyes was compared with that of stable adult donor eyes using high-throughput microarray and quantitative PCR analyses. Scleral samples from normal human fetal (24 wk) and normal adult donor eyes were obtained (n=4 to 6, each group), and RNA extracted. Genome-wide micro-RNA profiling was performed using the Agilent micro-RNA microarray platform. Micro-RNA target predictions were obtained using Microcosm, TargetScan and PicTar algorithms. TaqMan® micro-RNA assays targeting micro-RNAs showing either highest significance, detection, or fold differences, and collagen specificity, were applied to scleral samples from posterior and peripheral ocular regions (n=7, each group). Microarray data were analyzed using R, and quantitative PCR data with 2^-deltaCt methods. Human sclera was found to express micro-RNAs, and comparison of microarray results for adult and fetal samples revealed many to be differentially expressed (pmicro-RNA expression has been catalogued in human sclera. Some micro-RNAs show age-related differential regulation, higher in the sclera of rapidly growing fetal eyes, consistent with a role in ocular growth regulation. Thus micro-RNAs represent potential targets for ocular growth manipulation, related to myopia and/or other disorders such as scleral ectasia.

  4. The nova-like variable KQ Mon and the nature of the UX Ursa Majoris stars

    Science.gov (United States)

    Sion, E. M.; Guinan, E. F.

    1982-01-01

    The KQ Mon is a UX UMa type nova-like variable discovered by Howard Bond. Optical spectra taken by Bond in 1978 reveal very shallow Balmer absorption lines and He I absorption. Bond also did UBV and high speed photometry in 1978 and early 1981. There has been no evidence of orbital variations but the appearance of the optical spectrum and the presence of low amplitude flickering suggested a strong similarity to CD-42-14462 (=V3885 Sgr) and other members of the UX UMa class. Low dispersion observations of KQ Mon were made with the International Ultraviolet Explorer satellite. Six spectra taken with the shot wavelength prime camera are dominated by strong broad absorption lines due to N V, O I, Si III, Si IV, C IV, He II, N IV, and Al III. There is little evidence of orbital phase modulation over the time baseline of the observations. Unlike UV observations of other UX UMa type objects, KQ Mon exhibits no emission lines or P Cygni type profiles and the velocity displacements appear to be smaller, suggesting the absence of a hot, high velocity wind characterizing other UX UMa stars. The relationship of KQ Mon to other UX UMa disk stars is discussed and a model is suggested to explain their observed properties and the lack of major outbursts.

  5. Inferring data-specific micro-RNA function through the joint ranking of micro-RNA and pathways from matched micro-RNA and gene expression data.

    Science.gov (United States)

    Patrick, Ellis; Buckley, Michael; Müller, Samuel; Lin, David M; Yang, Jean Y H

    2015-09-01

    In practice, identifying and interpreting the functional impacts of the regulatory relationships between micro-RNA and messenger-RNA is non-trivial. The sheer scale of possible micro-RNA and messenger-RNA interactions can make the interpretation of results difficult. We propose a supervised framework, pMim, built upon concepts of significance combination, for jointly ranking regulatory micro-RNA and their potential functional impacts with respect to a condition of interest. Here, pMim directly tests if a micro-RNA is differentially expressed and if its predicted targets, which lie in a common biological pathway, have changed in the opposite direction. We leverage the information within existing micro-RNA target and pathway databases to stabilize the estimation and annotation of micro-RNA regulation making our approach suitable for datasets with small sample sizes. In addition to outputting meaningful and interpretable results, we demonstrate in a variety of datasets that the micro-RNA identified by pMim, in comparison to simpler existing approaches, are also more concordant with what is described in the literature. This framework is implemented as an R function, pMim, in the package sydSeq available from http://www.ellispatrick.com/r-packages. jean.yang@sydney.edu.au Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  6. MicroRNA and metabolism regulation%MicroRNA在调控物质代谢方面的作用

    Institute of Scientific and Technical Information of China (English)

    李明; 谢慧清; 熊武; 徐丹; 曹科; 刘睿; 周建大; 罗成群

    2013-01-01

    MicroRNAs have been identified as a new class of regulatory molecules that affect many biological funtions by interferring the target gene expressions. Latest studies demostrate that microRNAs can influence many pivotal bio-processes and deeply involve in the metabolism of glucose, lipid and amino acid and biological oxidation. For glucose metabolism, microRNAs are related to insulin secretion, insulin sensitivity, glucose uptake, glycolysis, oxidation and mitochondrial function. For lipid matebolism, microRNAs can regulate the target genes related to lipid biosynthesis, catabolism and transportation. MicroRNAs can influence glutamine catabolism.%MicroRNA通过干预靶基因表达水平构建了复杂的调控网络,调控生命活动的进行.目前已发现microRNA广泛参与葡萄糖、脂类、氨基酸的代谢及生物氧化过程,在一些重要位点上发挥调控作用.在人体摄取和利用葡萄糖过程中,microRNA参与调控胰岛素分泌、胰岛素敏感性、细胞对葡萄糖摄取、细胞内糖酵解途径等,并可影响线粒体功能及有氧氧化.在脂类代谢中,microRNA作用于脂类合成、分解及转运相关的靶基因,调控体内脂类代谢.此外,microRNA还与谷氨酰胺异化代谢有关.

  7. Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells.

    Directory of Open Access Journals (Sweden)

    Beatrice Cardinali

    Full Text Available BACKGROUND: MicroRNAs (miRNAs are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation. METHODOLOGY/PRINCIPAL FINDINGS: By comparing miRNA expression profiling of proliferating myoblasts versus differentiated myotubes, a number of modulated miRNAs, not previously implicated in regulation of myogenic differentiation, were identified. Among these, miR-221 and miR-222 were strongly down-regulated upon differentiation of both primary and established myogenic cells. Conversely, miR-221 and miR-222 expression was restored in post-mitotic, terminally differentiated myotubes subjected to Src tyrosine kinase activation. By the use of specific inhibitors we provide evidence that expression of miR-221 and miR-222 is under the control of the Ras-MAPK pathway. Both in myoblasts and in myotubes, levels of the cell cycle inhibitor p27 inversely correlated with miR-221 and miR-222 expression, and indeed we show that p27 mRNA is a direct target of these miRNAs in myogenic cells. Ectopic expression of miR-221 and miR-222 in myoblasts undergoing differentiation induced a delay in withdrawal from the cell cycle and in myogenin expression, followed by inhibition of sarcomeric protein accumulation. When miR-221 and miR-222 were expressed in myotubes undergoing maturation, a profound alteration of myofibrillar organization was observed. CONCLUSIONS/SIGNIFICANCE: miR-221 and miR-222 have been found to be modulated during myogenesis and to play a role both in the progression from myoblasts to myocytes and in the achievement of the fully differentiated phenotype. Identification of miRNAs modulating muscle gene expression is crucial for the understanding of the circuits

  8. The panchromatic spectroscopic evolution of the classical CO nova V339 Delphini (Nova Del 2013) until X-ray turnoff

    Science.gov (United States)

    Shore, S. N.; Mason, E.; Schwarz, G. J.; Teyssier, F. M.; Buil, C.; De Gennaro Aquino, I.; Page, K. L.; Osborne, J. P.; Scaringi, S.; Starrfield, S.; van Winckel, H.; Williams, R. E.; Woodward, C. E.

    2016-05-01

    Context. Classical novae are the product of thermonuclear runaway-initiated explosions occurring on accreting white dwarfs. Aims: V339 Del (Nova Delphinus 2013) was one of the brightest classical novae of the last hundred years. Spectroscopy and photometry are available from γ-rays through infrared at stages that have frequently not been observed well. The complete data set is intended to provide a benchmark for comparison with modeling and for understanding more sparsely monitored historical classical and recurrent novae. This paper is the first in the series of reports on the development of the nova. We report here on the early stages of the outburst, through the X-ray active stage. Methods: A time sequence of optical, flux calibrated high resolution spectra was obtained with the Nordic Optical Telescope (NOT) using FIES simultaneously, or contemporaneously, with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope during the early stages of the outburst. These were supplemented with Mercator/HERMES optical spectra. High resolution IUE ultraviolet spectra of OS And 1986, taken during the Fe curtain phase, served as a template for the distance determination. We used standard plasma diagnostics (e.g., [O III] and [N II] line ratios, and the Hβ line flux) to constrain electron densities and temperatures of the ejecta. Using Monte Carlo modeling of the ejecta, we derived the structure, filling factor, and mass from comparisons of the optical and ultraviolet line profiles. Results: We derive an extinction of E(B - V) = 0.23 ± 0.05 from the spectral energy distribution, the interstellar absorption, and H I emission lines. The distance, about 4-4.5 kpc, is in agreement with the inferred distance from near infrared interferometry. The maximum velocity was about 2500 km s-1, measured from the UV resonance and optical profiles. The ejecta showed considerable fine structure in all transitions, much of which persisted as emission knots. The

  9. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

    NARCIS (Netherlands)

    Berezikov, Eugene; van Tetering, Geert; Verheul, Mark; van de Belt, Jose; van Laake, Linda; Vos, Joost; Verloop, Robert; van de Wetering, Marc; Guryev, Victor; Takada, Shuji; van Zonneveld, Anton Jan; Mano, Hiroyuki; Plasterk, Ronald; Cuppen, Edwin

    2006-01-01

    MicroRNAs are 20- to 23-nucleotide RNA molecules that can regulate gene expression. Currently > 400 microRNAs have been experimentally identified in mammalian genomes, whereas estimates go up to 1000 and beyond. Here we show that many more mammalian microRNAs exist. We discovered novel microRNA cand

  10. Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer

    DEFF Research Database (Denmark)

    Winther, Mette; Alsner, Jan; Sørensen, Brita Singers

    2016-01-01

    BACKGROUND/AIM: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). MATERIALS AND METHODS: microRNA expression changes induced by hypoxia in human GEC cell lines were...

  11. Hypoxia-regulated MicroRNAs in gastroesophageal cancer

    DEFF Research Database (Denmark)

    Winther, M.; Alsner, J.; Sørensen, B.S.

    2016-01-01

    Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were...

  12. Semiconserved regulation of mesendoderm differentiation by microRNAs.

    NARCIS (Netherlands)

    Ketting, R.F.

    2009-01-01

    MicroRNAs are known to play important roles in many different processes. However, their roles in shaping the early steps in embryogenesis have remained largely hidden. In this issue of Developmental Cell, Rosa et al. show that the miR-430/427/302 family of microRNAs has a distinct effect on Nodal

  13. Next-generation sequencing of the porcine skeletal muscle transcriptome for computational prediction of microRNA gene targets.

    Directory of Open Access Journals (Sweden)

    Tara G McDaneld

    Full Text Available BACKGROUND: MicroRNA are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts through targeting of a microRNA-protein complex by base-pairing of the microRNA sequence to cognate recognition sequences in the 3' untranslated region (UTR of the mRNA. Target identification for a given microRNA sequence is generally accomplished by informatics analysis of predicted mRNA sequences present in the genome or in databases of transcript sequence for the tissue of interest. However, gene models for porcine skeletal muscle transcripts in current databases, specifically complete sequence of the 3' UTR, are inadequate for this exercise. METHODOLOGY/PRINCIPAL FINDINGS: To provide data necessary to identify gene targets for microRNA in porcine skeletal muscle, normalized cDNA libraries were sequenced using Roche 454 GS-FLX pyrosequencing and de novo assembly of transcripts enriched in the 3' UTR was performed using the MIRA sequence assembly program. Over 725 million bases of sequence were generated, which assembled into 18,202 contigs. Sequence reads were mapped to a 3' UTR database containing porcine sequences. The 3' UTR that mapped to the database were examined to predict targets for previously identified microRNA that had been separately sequenced from the same porcine muscle sample used to generate the cDNA libraries. For genes with microRNA-targeted 3' UTR, KEGG pathways were computationally determined in order to identify potential functional effects of these microRNA-targeted transcripts. CONCLUSIONS: Through next-generation sequencing of transcripts expressed in skeletal muscle, mapping reads to a 3' UTR database, and prediction of microRNA target sites in the 3' UTR, our results identified genes expressed in porcine skeletal muscle and predicted the microRNA that target these genes. Additionally, identification of pathways regulated by these microRNA-targeted genes provides us with a set of

  14. MicroRNA-126 inhibits the proliferation of lung cancer cell line A549

    Institute of Scientific and Technical Information of China (English)

    Xun Yang; Bei-Bei Chen; Ming-Hua Zhang; Xin-Rong Wang

    2015-01-01

    Objective:To study the role of microRNA-126 in the development of lung cancer.Methods:The biological function of microRNA-126 was detected using EdU assay and CCK-8 assay;the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.Results: In A549 cell line, overexpression of microRNA-126 inhibits the proliferation rate; VEGF is the target gene of microRNA-126; microRNA-126 exerts its function via regulating VEGF protein level.Conclusions: microRNA-126 inhibits the proliferation in A549 cell line.

  15. Complicated evolutionary patterns of microRNAs in vertebrates

    Institute of Scientific and Technical Information of China (English)

    WANG XiaoWo; ZHANG XueGong; LI YanDa

    2008-01-01

    MicroRNAs (miRNAs) are a class of~22 nt long endogenous non-coding RNAs that play important regulatory roles in diverse organisms. Up to now, little is known about the evolutionary properties of these crucial regulators. Most miRNAs were thought to be phylogenetically conserved, but recently, a number of poorly-conserved miRNAs have been reported and miRNA innovation is shown to be an ongoing process. In this work, through the characterization of an miRNA super family, we studied the evolutionary patterns of miRNAs in vertebrates. Recently generated miRNAs seem to evolve rapidly during a certain period following their emergence. Multiple lineage-specific expansions were observed. Homolgous premiRNAs may produce mature products from the opposite stem arms following tandem duplications, which may have important contribution to miRNA innovation. Our observations of miRNAs' complicated evolutionary patterns support the notion that these key regulatory molecules may play very active roles in evolution.

  16. MicroRNA networks direct neuronal development and plasticity.

    Science.gov (United States)

    Olde Loohuis, N F M; Kos, A; Martens, G J M; Van Bokhoven, H; Nadif Kasri, N; Aschrafi, A

    2012-01-01

    MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation.

  17. Alzheimer's disease: presence and role of microRNAs

    Science.gov (United States)

    Basavaraju, Manasa; de Lencastre, Alexandre

    2016-01-01

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050. AD is characterized by the accumulation of dense plaques of β-amyloid peptide (Aβ) and neurofibrillary tangles of hyperphosphorylated tau that cause impairment in memory, cognition, and daily activities. Although early-onset AD has been linked to several mutations, reliable genetic markers for late-onset AD are lacking. Further, the diagnosis of AD biomarkers has its limitations and cannot detect early-stage AD. The identification of accurate, early, and non-invasive biomarkers for AD is, therefore, an unmet challenge. Recently, micro-RNAs (miRNAs) have emerged as a novel class of gene regulatory elements with conserved roles in development and disease. Recent discoveries have uncovered roles of miRNAs in several model organisms during aging and have identified potential miRNAs biomarkers of AD. Here we will discuss this emerging field of miRNAs associated with AD and prospects for the future. PMID:27505094

  18. Decoding the ubiquitous role of microRNAs in neurogenesis.

    Science.gov (United States)

    Nampoothiri, Sreekala S; Rajanikant, G K

    2017-04-01

    Neurogenesis generates fledgling neurons that mature to form an intricate neuronal circuitry. The delusion on adult neurogenesis was far resolved in the past decade and became one of the largely explored domains to identify multifaceted mechanisms bridging neurodevelopment and neuropathology. Neurogenesis encompasses multiple processes including neural stem cell proliferation, neuronal differentiation, and cell fate determination. Each neurogenic process is specifically governed by manifold signaling pathways, several growth factors, coding, and non-coding RNAs. A class of small non-coding RNAs, microRNAs (miRNAs), is ubiquitously expressed in the brain and has emerged to be potent regulators of neurogenesis. It functions by fine-tuning the expression of specific neurogenic gene targets at the post-transcriptional level and modulates the development of mature neurons from neural progenitor cells. Besides the commonly discussed intrinsic factors, the neuronal morphogenesis is also under the control of several extrinsic temporal cues, which in turn are regulated by miRNAs. This review enlightens on dicer controlled switch from neurogenesis to gliogenesis, miRNA regulation of neuronal maturation and the differential expression of miRNAs in response to various extrinsic cues affecting neurogenesis.

  19. Tumor suppressor p53 meets microRNAs

    Institute of Scientific and Technical Information of China (English)

    Zhaohui Feng; Cen Zhang; Rui Wu; Wenwei Hu

    2011-01-01

    Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function through transcription regulation of its target genes to initiate various cellular responses. To maintain its proper function, p53 is tightly regulated by a wide variety of regulators in cells. Thus, p53, its regulators and regulated genes form a complex p53 network which is composed of hundreds of genes and their products. microRNAs (miRNAs) are a class of endogenously expressed, small non-coding RNA molecules which play a key role in regulation of gene expression at the post-transcriptional level. Recent studies have demonstrated that miRNAs interact with p53 and its network at multiple levels. p53 regulates the transcription expression and the maturation of a group of miRNAs. On the other hand, miRNAs can regulate the activity and function of p53 through direct repression of p53 or its regulators in cells. These findings have demonstrated that miRNAs are important components in the p53 network, and also added another layer of complexity to the p53 network.

  20. Regulatory roles of microRNAs in human dental tissues.

    Science.gov (United States)

    Sehic, Amer; Tulek, Amela; Khuu, Cuong; Nirvani, Minou; Sand, Lars Peter; Utheim, Tor Paaske

    2017-01-05

    MicroRNAs (miRNAs) are a class of small, non-coding RNAs that provide an efficient pathway for regulation of gene expression at a post-transcriptional level. Tooth development is regulated by a complex network of cell-cell signaling during all steps of organogenesis. Most of the congenital dental defects in humans are caused by mutations in genes involved in developmental regulatory networks. Whereas the developmental morphological stages of the tooth development already are thoroughly documented, the implicated genetic network is still under investigation. The involvement of miRNAs in the regulation of tooth genetic network was suggested for the first time in 2008. MiRNAs regulate tooth morphogenesis by fine-tuning the signaling networks. Unique groups of miRNAs are expressed in dental epithelium compared with mesenchyme, as well as in molars compared with incisors. The present review focuses on the current state of knowledge on the expression and function of miRNAs in human dental tissues, including teeth and the surrounding structures. Herein, we show that miRNAs exhibit specific roles in human dental tissues and are involved in gingival and periodontal disease, tooth movement and eruption, dental pulp physiology including repair and regeneration, differentiation of dental cells, and enamel mineralization. In light of similarities between the tooth development and other organs originating from the epithelium, further understanding of miRNAs` function in dental tissues may have wide biological relevance. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. microRNAs in Pancreatic β-Cell Physiology.

    Science.gov (United States)

    Özcan, Sabire

    2015-01-01

    The β-cells within the pancreas are responsible for production and secretion of insulin. Insulin is released from pancreatic β-cells in response to increasing blood glucose levels and acts on insulin-sensitive tissues such as skeletal muscle and liver in order to maintain normal glucose homeostasis. Therefore, defects in pancreatic β-cell function lead to hyperglycemia and diabetes mellitus. A new class of molecules called microRNAs has been recently demonstrated to play a crucial role in regulation of pancreatic β-cell function under normal and pathophysiological conditions. miRNAs have been shown to regulate endocrine pancreas development, insulin biosynthesis, insulin exocytosis, and β-cell expansion. Many of the β-cell enriched miRNAs have multiple functions and regulate pancreas development as well as insulin biosynthesis and exocytosis. Furthermore, several of the β-cell specific miRNAs have been shown to accumulate in the circulation before the onset of diabetes and may serve as potential biomarkers for prediabetes. This chapter will focus on miRNAs that are enriched in pancreatic β-cells and play a critical role in modulation of β-cell physiology and may have clinical significance in the treatment of diabetes.

  2. microRNA expression in the aging mouse lung

    Directory of Open Access Journals (Sweden)

    Moschos Sterghios A

    2007-06-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are a novel class of short double stranded RNA that mediate the post-transcriptional regulation of gene expression. Previous studies have implicated changes in miRNA expression in the regulation of development and the induction of diseases such as cancer. However, although miRNAs have been implicated in the process of aging in C. elegans, nothing is known of their role in mammalian tissues. Results To address this question, we have used a highly-sensitive, semi-quantitative RT-PCR based approach to measure the expression profile of 256 of the 493 currently identified miRNAs in the lungs from 6 month (adult and 18 month (aged old female BALB/c mice. We show that, despite the characteristic changes in anatomy and gene expression associated with lung aging, there were no significant changes in the expression of 256 miRNAs. Conclusion Overall, these results show that miRNA transcription is unchanged during lung aging and suggests that stable expression of miRNAs might instead buffer age related changes in the expression of protein-encoding genes.

  3. MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy.

    Science.gov (United States)

    Simpson, Kate; Wonnacott, Alexa; Fraser, Donald J; Bowen, Timothy

    2016-03-01

    Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes are limited and can be invasive, and interventions to delay progression are challenging. MicroRNAs (miRNAs) are a recently described class of molecular regulators found ubiquitously in human tissues and bodily fluids, where they are highly stable. Alterations in miRNA expression profiles have been observed in numerous diseases. Blood and tissue miRNAs are already established cancer biomarkers, and cardiovascular, metabolic and immune disease miRNA biomarkers are under development. Urinary miRNAs represent a potential novel source of non-invasive biomarkers for kidney diseases, including DN. In addition, recent data suggest that miRNAs may have therapeutic applications. Here, we review the utility of miRNAs as biomarkers for the early detection and progression of DN, assess emerging data on miRNAs implicated in DN pathology and discuss how the data from both fields may contribute to the development of novel therapeutic agents.

  4. Circulating MicroRNAs as Potential Biomarkers of Exercise Response

    Directory of Open Access Journals (Sweden)

    Mája Polakovičová

    2016-10-01

    Full Text Available Systematic physical activity increases physical fitness and exercise capacity that lead to the improvement of health status and athletic performance. Considerable effort is devoted to identifying new biomarkers capable of evaluating exercise performance capacity and progress in training, early detection of overtraining, and monitoring health-related adaptation changes. Recent advances in OMICS technologies have opened new opportunities in the detection of genetic, epigenetic and transcriptomic biomarkers. Very promising are mainly small non-coding microRNAs (miRNAs. miRNAs post-transcriptionally regulate gene expression by binding to mRNA and causing its degradation or inhibiting translation. A growing body of evidence suggests that miRNAs affect many processes and play a crucial role not only in cell differentiation, proliferation and apoptosis, but also affect extracellular matrix composition and maintaining processes of homeostasis. A number of studies have shown changes in distribution profiles of circulating miRNAs (c-miRNAs associated with various diseases and disorders as well as in samples taken under physiological conditions such as pregnancy or physical exercise. This overview aims to summarize the current knowledge related to the response of blood c-miRNAs profiles to different modes of exercise and to highlight their potential application as a novel class of biomarkers of physical performance capacity and training adaptation.

  5. Urinary exosomal microRNAs in incipient diabetic nephropathy.

    Science.gov (United States)

    Barutta, Federica; Tricarico, Marinella; Corbelli, Alessandro; Annaratone, Laura; Pinach, Silvia; Grimaldi, Serena; Bruno, Graziella; Cimino, Daniela; Taverna, Daniela; Deregibus, Maria Chiara; Rastaldi, Maria Pia; Perin, Paolo Cavallo; Gruden, Gabriella

    2013-01-01

    MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Results showed that miR-130a and miR-145 were enriched, while miR-155 and miR-424 reduced in urinary exosomes from patients with microalbuminuria. Similarly, in an animal model of early experimental diabetic nephropathy, urinary exosomal miR-145 levels were increased and this was paralleled by miR-145 overexpression within the glomeruli. Exposure of cultured mesangial cells to high glucose increased miR-145 content in both mesangial cells and mesangial cells-derived exosomes, providing a potential mechanism for diabetes-induced miR-145 overexpression. In conclusion, urinary exosomal miRNA content is altered in type 1 diabetic patients with incipient diabetic nephropathy and miR-145 may represent a novel candidate biomarker/player in the complication.

  6. Urinary exosomal microRNAs in incipient diabetic nephropathy.

    Directory of Open Access Journals (Sweden)

    Federica Barutta

    Full Text Available MicroRNAs (miRNAs, a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Results showed that miR-130a and miR-145 were enriched, while miR-155 and miR-424 reduced in urinary exosomes from patients with microalbuminuria. Similarly, in an animal model of early experimental diabetic nephropathy, urinary exosomal miR-145 levels were increased and this was paralleled by miR-145 overexpression within the glomeruli. Exposure of cultured mesangial cells to high glucose increased miR-145 content in both mesangial cells and mesangial cells-derived exosomes, providing a potential mechanism for diabetes-induced miR-145 overexpression. In conclusion, urinary exosomal miRNA content is altered in type 1 diabetic patients with incipient diabetic nephropathy and miR-145 may represent a novel candidate biomarker/player in the complication.

  7. Circulating MicroRNAs and Life Expectancy Among Identical Twins.

    Science.gov (United States)

    Wu, Shenghui; Kim, Taek-Kyun; Wu, Xiaogang; Scherler, Kelsey; Baxter, David; Wang, Kai; Krasnow, Ruth E; Reed, Terry; Dai, Jun

    2016-09-01

    Human life expectancy is influenced not only by longevity assurance mechanisms and disease susceptibility loci but also by the environment, gene-environment interactions, and chance. MicroRNAs (miRNAs) are a class of small noncoding RNAs closely related to genes. Circulating miRNAs have been shown as promising noninvasive biomarkers in the development of many pathophysiological conditions. However, the concentration of miRNA in the circulation may also be affected by environmental factors. We used a next-generation sequencing platform to assess the association of circulating miRNA with life expectancy, for which deaths are due to all causes independent of genes. In addition, we showed that miRNAs are present in 41-year archived plasma samples, which may be useful for both life expectancy and all-cause mortality risk assessment. Plasma miRNAs from nine identical male twins were profiled using next-generation sequencing. The average absolute difference in the minimum life expectancy was 9.68 years. Intraclass correlation coefficients were above 0.4 for 50% of miRNAs. Comparing deceased twins with their alive co-twin brothers, the concentrations were increased for 34 but decreased for 30 miRNAs. Identical twins discordant in life expectancy were dissimilar in the majority of miRNAs, suggesting that environmental factors are pivotal in miRNAs related to life expectancy.

  8. Role of microRNA machinery in kidney fibrosis.

    Science.gov (United States)

    Wang, Bo; Ricardo, Sharon

    2014-08-01

    MicroRNAs (miRNAs) are small non-coding RNAs that are critical regulators of gene expression at the post-transcriptional level. The miRNAs constitute an abundant class of RNAs conserved from plants to animals and, as such, play key roles in diverse biological processes, including inflammation, development, differentiation and apoptosis. More recently, it has become apparent that changes in miRNA expression contribute to a wide spectrum of human pathologies, including heart and kidney disease, organ developmental abnormalities and neuronal degeneration. Moreover, inflammation and the development of kidney fibrosis is accompanied by changes in miRNA expression. This review summarizes the emerging field deciphering the complex connections between human miRNA biology and different aspects of kidney injury, focusing on kidney fibrosis. The miRNA-regulated fibrosis is discussed based on the classification of pivotal mechanisms, notably involving the transforming growth factor-β1 signalling pathway. In addition, the challenge of miRNA delivery vehicles as mechanisms of cellular transfer are reviewed, as is the use of miRNA as a potential biomarker for disease.

  9. microRNAs- powerful repression comes from small RNAs

    Institute of Scientific and Technical Information of China (English)

    MA Cong; LIU YuFei; HE Lin

    2009-01-01

    microRNAs (miRNAs) encode a novel class of small, non-coding RNAs that regulate gene expression post-trancriptionally, miRNAs comprise one of the major non-coding RNA families, whose diverse bio-logical functions and unusual capacity for gene regulation have attracted enormous interests in the RNA world. Over the past 16 years, genetic, biochemical and computational approaches have greatly shaped the growth of the field, leading to the identification of thousands of miRNA genes in nearly all metazoans. The key molecular machinery for miRNA biogenesis and silencing has been identified, yet the precise biochemical and regulatory mechanisms still remain elusive. However, recent findings have shed new light on how miRNAs are generated and how they function to repress gene expression.miRNAs provide a paradigm for endogenous small RNAs that mediate gene silencing at a genome-wide level. The gene silencing mediated by these small RNAs constitutes a major component of gene regu-lation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a now dimension to our understanding about the complex gene regulatory networks.

  10. MicroRNAs: an epigenetic tool to study celiac disease

    Directory of Open Access Journals (Sweden)

    Karla A. Bascuñán-Gamboa

    2014-05-01

    Full Text Available This article summarizes recent findings on the role of microRNAs (miRNAs in biological processes associated with the regulation of chronic inflammation and autoimmunity. miRNAs are small non-coding RNA molecules that have been recently emerged as a new class of modulators of gene expression at the post-transcriptional level. MiRNAs bind to complementary sequences of specific targets of messengers RNA, which can interfere with protein synthesis. We reviewed studies that evaluated the expression patterns of miRNAs in different autoimmune diseases, especially in celiac disease (CD. CD is a chronic enteropathy triggered by gluten proteins, characterized by altered immune responses in genetically susceptible individuals that results in damage to the bowel mucosa. CD has a high prevalence and an effective treatment by a specific diet ("gluten free diet". Genetic factors confer susceptibility but do not explain the whole disease, suggesting that environmental factors do play a relevant role in the development of the condition. The evaluation of the potential role of miRNA is of particular interest in CD given that these epigenetic mechanisms in the pathogenesis of autoimmune and inflammatory diseases have been recently described. Improving our understanding of miRNAs in CD will contribute to clarify the role of altered epigenetic regulation in the development and course of this disease.

  11. MicroRNAs in NF-κB signaling

    Institute of Scientific and Technical Information of China (English)

    Xiaodong Ma; Lindsey E. Becker Buscaglia; Juanita R. Barker; Yong Li

    2011-01-01

    Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor development. MicroRNAs (miRNAs) are short RNA molecules of 20-25nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3' untranslated regions of mRNAs. In this work, we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases, particularly in cancer. The function of miR-146, miR-155, miR-181b, miR-21, and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed. Given that over 1000 human miRNAs have been identified, rendering miRNAs one of the most abundant classes of regulatory molecules, deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer.

  12. Circulating microRNAs as Potential Biomarkers of Infectious Disease

    Science.gov (United States)

    Correia, Carolina N.; Nalpas, Nicolas C.; McLoughlin, Kirsten E.; Browne, John A.; Gordon, Stephen V.; MacHugh, David E.; Shaughnessy, Ronan G.

    2017-01-01

    microRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules that regulate a wide range of biological processes by post-transcriptionally regulating gene expression. Thousands of these molecules have been discovered to date, and multiple miRNAs have been shown to coordinately fine-tune cellular processes key to organismal development, homeostasis, neurobiology, immunobiology, and control of infection. The fundamental regulatory role of miRNAs in a variety of biological processes suggests that differential expression of these transcripts may be exploited as a novel source of molecular biomarkers for many different disease pathologies or abnormalities. This has been emphasized by the recent discovery of remarkably stable miRNAs in mammalian biofluids, which may originate from intracellular processes elsewhere in the body. The potential of circulating miRNAs as biomarkers of disease has mainly been demonstrated for various types of cancer. More recently, however, attention has focused on the use of circulating miRNAs as diagnostic/prognostic biomarkers of infectious disease; for example, human tuberculosis caused by infection with Mycobacterium tuberculosis, sepsis caused by multiple infectious agents, and viral hepatitis. Here, we review these developments and discuss prospects and challenges for translating circulating miRNA into novel diagnostics for infectious disease. PMID:28261201

  13. MicroRNAs in dysfunctional adipose tissue: cardiovascular implications.

    Science.gov (United States)

    Icli, Basak; Feinberg, Mark W

    2017-07-01

    In this review, we focus on the emerging role of microRNAs, non-coding RNAs that regulate gene expression and signaling pathways, in dysfunctional adipose tissue. We highlight current paradigms of microRNAs involved in adipose differentiation and function in depots such as white, brown, and beige adipose tissues and potential implications of microRNA dysregulation in human disease such as obesity, inflammation, microvasculature dysfunction, and related cardiovascular diseases. We highlight accumulating studies indicating that adipocyte-derived microRNAs may not only serve as biomarkers of cardiometabolic disease, but also may directly regulate gene expression of other tissues. Finally, we discuss the future prospects, challenges, and emerging strategies for microRNA delivery and targeting for therapeutic applications in cardiovascular disease states associated with adipocyte dysfunction. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

  14. MicroRNA-146a: A dominant, negative regulator of the innate immune response

    Directory of Open Access Journals (Sweden)

    Stephanie eBooth

    2014-11-01

    Full Text Available MicroRNAs (miRNAs are a class of small non-coding RNA molecules that can play critical roles as regulators of numerous pathways and biological processes including the immune response. Emerging as one of the most important miRNAs to orchestrate immune and inflammatory signaling, often through its recognized target genes, IRAK1 and TRAF6, is microRNA-146a (miR-146a. MiR-146a is one, of a small number of miRNAs, whose expression is strongly induced following challenge of cells with bacterial endotoxin, and prolonged expression has been linked to immune tolerance, implying that it acts as a fine tuning mechanism to prevent an overstimulation of the inflammatory response. In other cells, miR-146a has been shown to play a role in the control of the differentiation of megakaryocytic and monocytic lineages, adaptive immunity and cancer. In this review, we discuss the central role prescribed to miR-146a in innate immunity. We particularly focus on the role played by miR-146a in the regulation and signaling mediated by one of the main pattern recognition receptors, Toll/IL-1 receptors (TLRs. Additionally, we also discuss the role of miR-146a in several classes of autoimmune pathologies where this miRNA has been shown to be dysregulated, as well as its potential role in the pathobiology of neurodegenerative diseases.

  15. The Radio Light Curve of the Gamma-Ray Nova in V407 CYG: Thermal Emission from the Ionized Symbiotic Envelope, Devoured from Within by the Nova Blast

    Science.gov (United States)

    Chomiuk, Laura; Krauss, Miriam I.; Rupen, Michael P.; Nelson, Thomas; Roy, Nirupam; Sokoloski, Jennifer L.; Mukai, Koji; Munari, Ulisse; Mioduszewski, Amy; Weston, Jeninfer; O'Brien, Tim J.; Eyres, Steward P. S.; Bode, Michael F.

    2012-01-01

    We present multi-frequency radio observations of the 2010 nova event in the symbiotic binary V407 Cygni, obtained with the Karl G. Jansky Very Large Array (VLA) and spanning 1.45 GHz and 17.770 days following discovery. This nova.the first ever detected in gamma rays.shows a radio light curve dominated by the wind of the Mira giant companion, rather than the nova ejecta themselves. The radio luminosity grewas the wind became increasingly ionized by the nova outburst, and faded as the wind was violently heated from within by the nova shock. This study marks the first time that this physical mechanism has been shown to dominate the radio light curve of an astrophysical transient. We do not observe a thermal signature from the nova ejecta or synchrotron emission from the shock, due to the fact that these components were hidden behind the absorbing screen of the Mira wind. We estimate a mass-loss rate for the Mira wind of .Mw approximately equals 10(exp -6) Solar mass yr(exp -1). We also present the only radio detection of V407 Cyg before the 2010 nova, gleaned from unpublished 1993 archival VLA data, which shows that the radio luminosity of the Mira wind varies by a factor of 20 even in quiescence. Although V407 Cyg likely hosts a massive accreting white dwarf, making it a candidate progenitor system for a Type Ia supernova, the dense and radially continuous circumbinary material surrounding V407 Cyg is inconsistent with observational constraints on the environments of most Type Ia supernovae.

  16. MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG.

    Science.gov (United States)

    Chen, Xiao-Ping; Chen, You-Guo; Lan, Jian-Yun; Shen, Zong-Ji

    2014-10-28

    MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally inhibit gene expression. In this study, we discovered that microRNA-370 (miR-370) was down-regulated in endometrioid ovarian cancer cells. In IGROV1 and TOV112D endometrioid ovarian cancer cells, miR-370 suppressed cellular viability and colony formation. miR-370 also enhanced endometrioid ovarian cancer cell chemosensitivity to cDDP. Endoglin (ENG) was directly and negatively regulated by miR-370. In addition, hypermethylation was a potential mechanism of miR-370 epigenetic silencing. We conclude that miR-370 acts as a tumor suppressor in endometrioid ovarian cancer via ENG regulation. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. Development and validation of a microRNA based diagnostic assay for primary tumor site classification of liver core biopsies

    DEFF Research Database (Denmark)

    Perell, Katharina; Vincent, Martin; Vainer, Ben;

    2015-01-01

    negatively affect the accuracy and usability of molecular classifiers. We have developed and validated a microRNA-based classifier, which predicts the primary tumor site of liver biopsies, containing a limited number of tumor cells. Concurrently we explored the influence of surrounding normal tissue...... for normal liver tissue contamination. Performance was estimated by cross-validation, followed by independent validation on 55 liver core biopsies with a tumor content as low as 10%. A microRNA classifier developed, using the statistical contamination model, showed an overall classification accuracy of 74...... on classification. MicroRNA profiling was performed using quantitative Real-Time PCR on formalin-fixed paraffin-embedded samples. 278 primary tumors and liver metastases, representing nine primary tumor classes, as well as normal liver samples were used as a training set. A statistical model was applied to adjust...

  18. The local stellar population of novae regions in the Large Magellanic Cloud

    CERN Document Server

    Subramanian, A; Subramaniam, Annapurni

    2002-01-01

    The distribution of novae across the face of the Large Magellanic Cloud (LMC) and star formation history (SFH) of nearby regions around them are presented using photometric data of stars and star clusters in the OGLE II survey and star cluster catalogues. The nova population in the LMC belong, predominantly to the fast category, with only 11.8% belonging to the slow nova population. All the novae detected within the Bar are fast novae.The age of the stellar population within a few arcmin around novae regions are estimated using isochrone fits to the V vs (V-I) colour-magnitude diagrams. Of the 15 regions studied, excepting the one around the slow nova, all the other regions do not show stellar population in the range 4 - 10 Gyr and the star formation is found to have started between 4 - 2.0 Gyr, with a majority of regions starting the star formation at 3.2 Gyr. This star formation event lasted until 1.6 - 1.8 Gyr. Based on the SFH, it is estimated that the parent population of the fast and moderately fast nov...

  19. Constraining nova observables: direct measurements of resonance strengths in 33S(p,\\gamma)34Cl

    CERN Document Server

    Fallis, J; Bertone, P F; Bishop, S; Buchmann, L; Chen, A A; Christian, G; Clark, J A; D'Auria, J M; Davids, B; Deibel, C M; Fulton, B R; Greife, U; Guo, B; Hager, U; Herlitzius, C; Hutcheon, D A; José, J; Laird, A M; Li, E T; Li, Z H; Lian, G; Liu, W P; Martin, L; Nelson, K; Ottewell, D; Parker, P D; Reeve, S; Rojas, A; Ruiz, C; Setoodehnia, K; Sjue, S; Vockenhuber, C; Wang, Y B; Wrede, C

    2013-01-01

    The 33S(p,\\gamma)34Cl reaction is important for constraining predictions of certain isotopic abundances in oxygen-neon novae. Models currently predict as much as 150 times the solar abundance of 33S in oxygen-neon nova ejecta. This overproduction factor may, however, vary by orders of magnitude due to uncertainties in the 33S(p,\\gamma)34Cl reaction rate at nova peak temperatures. Depending on this rate, 33S could potentially be used as a diagnostic tool for classifying certain types of presolar grains. Better knowledge of the 33S(p,\\gamma)34Cl rate would also aid in interpreting nova observations over the S-Ca mass region and contribute to the firm establishment of the maximum endpoint of nova nucleosynthesis. Additionally, the total S elemental abundance which is affected by this reaction has been proposed as a thermometer to study the peak temperatures of novae. Previously, the 33S(p,\\gamma)34Cl reaction rate had only been studied directly down to resonance energies of 432 keV. However, for nova peak temper...

  20. The 30P(p, γ31S reaction in classical novae: progress and prospects

    Directory of Open Access Journals (Sweden)

    C. Wrede

    2014-01-01

    Full Text Available The unknown thermonuclear rate of the 30P(p, γ31S reaction at classical-nova temperatures currently prohibits the accurate modeling of nova nucleosynthesis in the A ⩾ 30 region. This is hindering the calibration of nova thermometers based on observed O/S, S/Al, O/P, and P/Al abundance ratios in nova ejecta, the calibration of a meter to probe mixing at the core-envelope interface in novae based on the observed Si/H abundance ratio, and the identification of candidate pre-solar nova grains found in primitive meteorites based on laboratory measurements of their 30Si/28Si isotopic ratios. Each of these diagnostics could address key questions in our understanding of classical novae if the 30P(p, γ31S rate were known. We review progress on the determination of the 30P(p, γ31S rate leading to a critical assessment of current interpretations of published data and prospects for future work.

  1. First Measurement of Electron Neutrino Appearance in NOvA.

    Science.gov (United States)

    Adamson, P; Ader, C; Andrews, M; Anfimov, N; Anghel, I; Arms, K; Arrieta-Diaz, E; Aurisano, A; Ayres, D S; Backhouse, C; Baird, M; Bambah, B A; Bays, K; Bernstein, R; Betancourt, M; Bhatnagar, V; Bhuyan, B; Bian, J; Biery, K; Blackburn, T; Bocean, V; Bogert, D; Bolshakova, A; Bowden, M; Bower, C; Broemmelsiek, D; Bromberg, C; Brunetti, G; Bu, X; Butkevich, A; Capista, D; Catano-Mur, E; Chase, T R; Childress, S; Choudhary, B C; Chowdhury, B; Coan, T E; Coelho, J A B; Colo, M; Cooper, J; Corwin, L; Cronin-Hennessy, D; Cunningham, A; Davies, G S; Davies, J P; Del Tutto, M; Derwent, P F; Deepthi, K N; Demuth, D; Desai, S; Deuerling, G; Devan, A; Dey, J; Dharmapalan, R; Ding, P; Dixon, S; Djurcic, Z; Dukes, E C; Duyang, H; Ehrlich, R; Feldman, G J; Felt, N; Fenyves, E J; Flumerfelt, E; Foulkes, S; Frank, M J; Freeman, W; Gabrielyan, M; Gallagher, H R; Gebhard, M; Ghosh, T; Gilbert, W; Giri, A; Goadhouse, S; Gomes, R A; Goodenough, L; Goodman, M C; Grichine, V; Grossman, N; Group, R; Grudzinski, J; Guarino, V; Guo, B; Habig, A; Handler, T; Hartnell, J; Hatcher, R; Hatzikoutelis, A; Heller, K; Howcroft, C; Huang, J; Huang, X; Hylen, J; Ishitsuka, M; Jediny, F; Jensen, C; Jensen, D; Johnson, C; Jostlein, H; Kafka, G K; Kamyshkov, Y; Kasahara, S M S; Kasetti, S; Kephart, K; Koizumi, G; Kotelnikov, S; Kourbanis, I; Krahn, Z; Kravtsov, V; Kreymer, A; Kulenberg, Ch; Kumar, A; Kutnink, T; Kwarciancy, R; Kwong, J; Lang, K; Lee, A; Lee, W M; Lee, K; Lein, S; Liu, J; Lokajicek, M; Lozier, J; Lu, Q; Lucas, P; Luchuk, S; Lukens, P; Lukhanin, G; Magill, S; Maan, K; Mann, W A; Marshak, M L; Martens, M; Martincik, J; Mason, P; Matera, K; Mathis, M; Matveev, V; Mayer, N; McCluskey, E; Mehdiyev, R; Merritt, H; Messier, M D; Meyer, H; Miao, T; Michael, D; Mikheyev, S P; Miller, W H; Mishra, S R; Mohanta, R; Moren, A; Mualem, L; Muether, M; Mufson, S; Musser, J; Newman, H B; Nelson, J K; Niner, E; Norman, A; Nowak, J; Oksuzian, Y; Olshevskiy, A; Oliver, J; Olson, T; Paley, J; Pandey, P; Para, A; Patterson, R B; Pawloski, G; Pearson, N; Perevalov, D; Pershey, D; Peterson, E; Petti, R; Phan-Budd, S; Piccoli, L; Pla-Dalmau, A; Plunkett, R K; Poling, R; Potukuchi, B; Psihas, F; Pushka, D; Qiu, X; Raddatz, N; Radovic, A; Rameika, R A; Ray, R; Rebel, B; Rechenmacher, R; Reed, B; Reilly, R; Rocco, D; Rodkin, D; Ruddick, K; Rusack, R; Ryabov, V; Sachdev, K; Sahijpal, S; Sahoo, H; Samoylov, O; Sanchez, M C; Saoulidou, N; Schlabach, P; Schneps, J; Schroeter, R; Sepulveda-Quiroz, J; Shanahan, P; Sherwood, B; Sheshukov, A; Singh, J; Singh, V; Smith, A; Smith, D; Smolik, J; Solomey, N; Sotnikov, A; Sousa, A; Soustruznik, K; Stenkin, Y; Strait, M; Suter, L; Talaga, R L; Tamsett, M C; Tariq, S; Tas, P; Tesarek, R J; Thayyullathil, R B; Thomsen, K; Tian, X; Tognini, S C; Toner, R; Trevor, J; Tzanakos, G; Urheim, J; Vahle, P; Valerio, L; Vinton, L; Vrba, T; Waldron, A V; Wang, B; Wang, Z; Weber, A; Wehmann, A; Whittington, D; Wilcer, N; Wildberger, R; Wildman, D; Williams, K; Wojcicki, S G; Wood, K; Xiao, M; Xin, T; Yadav, N; Yang, S; Zadorozhnyy, S; Zalesak, J; Zamorano, B; Zhao, A; Zirnstein, J; Zwaska, R

    2016-04-15

    We report results from the first search for ν_{μ}→ν_{e} transitions by the NOvA experiment. In an exposure equivalent to 2.74×10^{20} protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99±0.11(syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07±0.14(syst). The 3.3σ excess of events observed in the primary analysis disfavors 0.1π<δ_{CP}<0.5π in the inverted mass hierarchy at the 90% C.L.

  2. First Measurement of Electron Neutrino Appearance in NOvA

    Science.gov (United States)

    Adamson, P.; Ader, C.; Andrews, M.; Anfimov, N.; Anghel, I.; Arms, K.; Arrieta-Diaz, E.; Aurisano, A.; Ayres, D. S.; Backhouse, C.; Baird, M.; Bambah, B. A.; Bays, K.; Bernstein, R.; Betancourt, M.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Biery, K.; Blackburn, T.; Bocean, V.; Bogert, D.; Bolshakova, A.; Bowden, M.; Bower, C.; Broemmelsiek, D.; Bromberg, C.; Brunetti, G.; Bu, X.; Butkevich, A.; Capista, D.; Catano-Mur, E.; Chase, T. R.; Childress, S.; Choudhary, B. C.; Chowdhury, B.; Coan, T. E.; Coelho, J. A. B.; Colo, M.; Cooper, J.; Corwin, L.; Cronin-Hennessy, D.; Cunningham, A.; Davies, G. S.; Davies, J. P.; Del Tutto, M.; Derwent, P. F.; Deepthi, K. N.; Demuth, D.; Desai, S.; Deuerling, G.; Devan, A.; Dey, J.; Dharmapalan, R.; Ding, P.; Dixon, S.; Djurcic, Z.; Dukes, E. C.; Duyang, H.; Ehrlich, R.; Feldman, G. J.; Felt, N.; Fenyves, E. J.; Flumerfelt, E.; Foulkes, S.; Frank, M. J.; Freeman, W.; Gabrielyan, M.; Gallagher, H. R.; Gebhard, M.; Ghosh, T.; Gilbert, W.; Giri, A.; Goadhouse, S.; Gomes, R. A.; Goodenough, L.; Goodman, M. C.; Grichine, V.; Grossman, N.; Group, R.; Grudzinski, J.; Guarino, V.; Guo, B.; Habig, A.; Handler, T.; Hartnell, J.; Hatcher, R.; Hatzikoutelis, A.; Heller, K.; Howcroft, C.; Huang, J.; Huang, X.; Hylen, J.; Ishitsuka, M.; Jediny, F.; Jensen, C.; Jensen, D.; Johnson, C.; Jostlein, H.; Kafka, G. K.; Kamyshkov, Y.; Kasahara, S. M. S.; Kasetti, S.; Kephart, K.; Koizumi, G.; Kotelnikov, S.; Kourbanis, I.; Krahn, Z.; Kravtsov, V.; Kreymer, A.; Kulenberg, Ch.; Kumar, A.; Kutnink, T.; Kwarciancy, R.; Kwong, J.; Lang, K.; Lee, A.; Lee, W. M.; Lee, K.; Lein, S.; Liu, J.; Lokajicek, M.; Lozier, J.; Lu, Q.; Lucas, P.; Luchuk, S.; Lukens, P.; Lukhanin, G.; Magill, S.; Maan, K.; Mann, W. A.; Marshak, M. L.; Martens, M.; Martincik, J.; Mason, P.; Matera, K.; Mathis, M.; Matveev, V.; Mayer, N.; McCluskey, E.; Mehdiyev, R.; Merritt, H.; Messier, M. D.; Meyer, H.; Miao, T.; Michael, D.; Mikheyev, S. P.; Miller, W. H.; Mishra, S. R.; Mohanta, R.; Moren, A.; Mualem, L.; Muether, M.; Mufson, S.; Musser, J.; Newman, H. B.; Nelson, J. K.; Niner, E.; Norman, A.; Nowak, J.; Oksuzian, Y.; Olshevskiy, A.; Oliver, J.; Olson, T.; Paley, J.; Pandey, P.; Para, A.; Patterson, R. B.; Pawloski, G.; Pearson, N.; Perevalov, D.; Pershey, D.; Peterson, E.; Petti, R.; Phan-Budd, S.; Piccoli, L.; Pla-Dalmau, A.; Plunkett, R. K.; Poling, R.; Potukuchi, B.; Psihas, F.; Pushka, D.; Qiu, X.; Raddatz, N.; Radovic, A.; Rameika, R. A.; Ray, R.; Rebel, B.; Rechenmacher, R.; Reed, B.; Reilly, R.; Rocco, D.; Rodkin, D.; Ruddick, K.; Rusack, R.; Ryabov, V.; Sachdev, K.; Sahijpal, S.; Sahoo, H.; Samoylov, O.; Sanchez, M. C.; Saoulidou, N.; Schlabach, P.; Schneps, J.; Schroeter, R.; Sepulveda-Quiroz, J.; Shanahan, P.; Sherwood, B.; Sheshukov, A.; Singh, J.; Singh, V.; Smith, A.; Smith, D.; Smolik, J.; Solomey, N.; Sotnikov, A.; Sousa, A.; Soustruznik, K.; Stenkin, Y.; Strait, M.; Suter, L.; Talaga, R. L.; Tamsett, M. C.; Tariq, S.; Tas, P.; Tesarek, R. J.; Thayyullathil, R. B.; Thomsen, K.; Tian, X.; Tognini, S. C.; Toner, R.; Trevor, J.; Tzanakos, G.; Urheim, J.; Vahle, P.; Valerio, L.; Vinton, L.; Vrba, T.; Waldron, A. V.; Wang, B.; Wang, Z.; Weber, A.; Wehmann, A.; Whittington, D.; Wilcer, N.; Wildberger, R.; Wildman, D.; Williams, K.; Wojcicki, S. G.; Wood, K.; Xiao, M.; Xin, T.; Yadav, N.; Yang, S.; Zadorozhnyy, S.; Zalesak, J.; Zamorano, B.; Zhao, A.; Zirnstein, J.; Zwaska, R.; NOvA Collaboration

    2016-04-01

    We report results from the first search for νμ→νe transitions by the NOvA experiment. In an exposure equivalent to 2.74 ×1020 protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99 ±0.11 (syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07 ±0.14 (syst) . The 3.3 σ excess of events observed in the primary analysis disfavors 0.1 π <δC P<0.5 π in the inverted mass hierarchy at the 90% C.L.

  3. NSV 1907 - A new eclipsing, nova-like cataclysmic variable

    CERN Document Server

    Hümmerich, Stefan; Hambsch, Franz-Josef; Dubois, Franky; Ashley, Richard; Gänsicke, Boris T; Vanaverbeke, Siegfried; Bernhard, Klaus; Wils, Patrick

    2016-01-01

    NSV 1907, formerly listed as an irregular variable in variability catalogues, was classified as an Algol-type eclipsing binary in the Catalina Surveys Periodic Variable Star Catalogue. We have identified NSV 1907 as an ultraviolet (UV) bright source using measurements from the GALEX space telescope and detected obvious out-of-eclipse variability in archival photometric data from the Catalina Sky Survey, which instigated a closer examination of the object. A spectrum and extensive multicolour photometric observations were acquired, from which we deduce that NSV 1907 is a deeply eclipsing, nova-like cataclysmic variable. Apart from the orbital variations (deep eclipses with a period of P ~ 6.63 hours), changes in mean brightness and irregular short-term variability (flickering) were observed. The presence of a secondary minimum at phase phi ~ 0.5 was established, which indicates a significant contribution of the companion star to the optical flux of the system. We find possible evidence for sinusoidal variation...

  4. Do policial ao noir: as novas faces da narrativa violenta

    Directory of Open Access Journals (Sweden)

    Paulo Sesar Pimentel

    2014-01-01

    Full Text Available O presente artigo se propõe a, num primeiro momento, descrever a evolução do gênero policial, do seu surgimento até sua transformação, numa nova categoria, designada por noir. Partindo deste ponto, trabalham-se as especificidades do chamado romance negro, suas motivações e suas peculiaridades, inseridas na estrutura social contemporânea, discutindo, por sua relação intrínseca, a violência e a morte. A fim de exemplificar esta construção narrativa, usa-se o conto "Tempestade sobre a Montanha", de Wander Antunes, numa análise que permite vislumbrar as manifestações temáticas e estruturais deste novo gênero adaptadas à realidade brasileira.

  5. Corpos e Corporeidade no Universo da Nova Era no Brasil

    Directory of Open Access Journals (Sweden)

    Amurabi Oliveira

    2012-08-01

    Full Text Available O presente trabalho busca explorar a dimensão corpórea enquanto central para a compreensão do fenômeno religioso, em especial do universo Nova Era – NE, em nossa interpretação o corpo apresenta-se enquanto estrutura estruturada estruturante que possibilita aos sujeitos vivenciar e interpretar o mundo, neste sentido, a experiência de imersão e de vivência das práticas da NE são, essencialmente, experiências corpóreas. No decorrer deste trabalho buscaremos dar destaque aos aspectos singulares da NE brasileira, em especial no que tange à dimensão do êxtase sagrado, principalmente a partir do diálogo com as religiões afro-brasileiras.

  6. NOVA: Program Summaries of New Science TV Series.

    Science.gov (United States)

    1974-03-22

    A new science television series now broadcast over the Public Broadcasting Service (PBS) will be of special interest to members of AAAS. The series, called NOVA, is produced by WGBH-TV, Boston, for PBS. The series has been created and produced with the advice and cooperation of AAAS, especially its Committee on the Public Understanding of Science and the Office of Communications Programs, as a major new effort at expanding the public's understanding of science and scientific processes. The series is financed by grants from the Carnegie Corporation of New York, the Corporation for Public Broadcasting, the National Science Foundation, and Polaroid. A list of program descriptions in the current series with network air dates follows. Consult your local listings for local times.

  7. On The Nature Of Superoutbursts In Dwarf Novae

    CERN Document Server

    Truss, M R; Wynn, G A; Truss, Michael; Murray, James; Wynn, Graham

    2001-01-01

    We present the first detailed hydrodynamic simulation of a superoutburst to incorporate the full tidal potential of a binary system. A two-dimensional smoothed particle hydrodynamics code is used to simulate a superoutburst in a binary with the parameters of the SU UMa system Z Chamaeleontis. The simulated light curves shows all the features observed in such systems. Analysis of the mass flux through the disc and the growth rate of the superhumps and disc eccentricity show that the superoutburst-superhump phenomenon is a direct result of tidal instability. No enhanced mass transfer from the secondary is required to initiate or sustain these phenomena. Comparisons of superoutbursts with normal outbursts are made and we show that the model can be reconciled with the behavior of U Geminorum type dwarf novae, which show no superoutbursts.

  8. O superego: em busca de uma nova abordagem

    Directory of Open Access Journals (Sweden)

    Marta Rezende Cardoso

    Full Text Available Este artigo apresenta a proposição de uma nova concepção do superego, segundo a qual os imperativos superegóicos seriam comparáveis, em todos os indivíduos, a um “enclave psicótico”. Trata-se aqui de aprofundar aspectos fundamentais da questão do superego, numa tentativa de elaborar alguns pontos que ficaram problemáticos em Freud, Melanie Klein e outros autores pós-freudianos. A obra de Jean Laplanche foi útil como fonte principal na formulação das hipóteses apresentadas cuja incidência na clínica psicanalítica parece inegável.

  9. High resolution spectra of novae and the quadratic zeeman effect

    Directory of Open Access Journals (Sweden)

    Robert Williams

    2006-01-01

    Full Text Available Los espectros de alta resoluci on de novas despu es de las erupciones revelan caracter sticas distintivas en los per les e intensidades de las l neas. Las l neas de Balmer m as altas son frecuentemente m as anchas que los miembros m as bajos de la serie, y los per les e intensidades relativos del doblete [O I] 6300, 6364 di eren de los valores normales. Nosotros sugerimos que estos aspectos pueden ser producidos por el efecto cuadr atico Zeeman desde campos magn eticos que exceden B=106 gauss. Tomadas juntas, las l neas de emisi on y absorci on indican m ultiples or genes para los materiales expulsados, tanto en las enanas blancas eruptivas como en las estrellas secundarias fr as.

  10. Regulation of cardiac microRNAs by serum response factor

    Directory of Open Access Journals (Sweden)

    Wei Jeanne Y

    2011-02-01

    Full Text Available Abstract Serum response factor (SRF regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in cardiac hypertrophy has not been well established. In this report, we employed two distinct transgenic mouse models to study the impact of SRF on cardiac microRNA expression and microRNA biogenesis. Cardiac-specific overexpression of SRF (SRF-Tg led to altered expression of a number of microRNAs. Interestingly, downregulation of miR-1, miR-133a and upregulation of miR-21 occurred by 7 days of age in these mice, long before the onset of cardiac hypertrophy, suggesting that SRF overexpression impacted the expression of microRNAs which contribute to cardiac hypertrophy. Reducing cardiac SRF level using the antisense-SRF transgenic approach (Anti-SRF-Tg resulted in the expression of miR-1, miR-133a and miR-21 in the opposite direction. Furthermore, we observed that SRF regulates microRNA biogenesis, specifically the transcription of pri-microRNA, thereby affecting the mature microRNA level. The mir-21 promoter sequence is conserved among mouse, rat and human; one SRF binding site was found to be in the mir-21 proximal promoter region of all three species. The mir-21 gene is regulated by SRF and its cofactors, including myocardin and p49/Strap. Our study demonstrates that the downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF. These results may help to develop novel therapeutic interventions targeting microRNA biogenesis.

  11. Rapid Generation of MicroRNA Sponges for MicroRNA Inhibition

    NARCIS (Netherlands)

    Kluiver, Joost; Gibcus, Johan H.; Hettinga, Chris; Adema, Annelies; Richter, Mareike K. S.; Halsema, Nancy; Slezak-Prochazka, Izabella; Ding, Ye; Kroesen, Bart-Jan; van den Berg, Anke

    2012-01-01

    MicroRNA (miRNA) sponges are transcripts with repeated miRNA antisense sequences that can sequester miRNAs from endogenous targets. MiRNA sponges are valuable tools for miRNA loss-of-function studies both in vitro and in vivo. We developed a fast and flexible method to generate miRNA sponges and tes

  12. Rapid Generation of MicroRNA Sponges for MicroRNA Inhibition

    NARCIS (Netherlands)

    Kluiver, Joost; Gibcus, Johan H.; Hettinga, Chris; Adema, Annelies; Richter, Mareike K. S.; Halsema, Nancy; Slezak-Prochazka, Izabella; Ding, Ye; Kroesen, Bart-Jan; van den Berg, Anke

    2012-01-01

    MicroRNA (miRNA) sponges are transcripts with repeated miRNA antisense sequences that can sequester miRNAs from endogenous targets. MiRNA sponges are valuable tools for miRNA loss-of-function studies both in vitro and in vivo. We developed a fast and flexible method to generate miRNA sponges and

  13. MicroRNA in 2012: Biotherapeutic potential of microRNAs in rheumatic diseases.

    Science.gov (United States)

    Pers, Yves-Marie; Jorgensen, Christian

    2013-02-01

    A number of microRNAs have been implicated in the pathogenesis of various rheumatic diseases, and evidence in support of the therapeutic potential of microRNA-based strategies for these conditions is growing, as demonstrated by several new findings published in 2012.

  14. Ten-year literature review of global endometrial ablation with the NovaSure® device

    Directory of Open Access Journals (Sweden)

    Gimpelson RJ

    2014-03-01

    Full Text Available Richard J Gimpelson Mercy Clinic, Minimally Invasive Gynecology, Department of Obstetrics and Gynecology, Mercy Hospital St Louis, St Louis, MO, USA Abstract: This review examines the peer-reviewed literature describing prospective studies that report amenorrhea rates, patient satisfaction, and surgical reintervention rates following the NovaSure® endometrial ablation procedure. A search of the English-language literature published from 2000 to 2011 was conducted using PubMed. Ten prospective studies, six single-arm NovaSure trials, and four randomized controlled trials comparing the NovaSure procedure with other global endometrial ablation modalities met the inclusion criteria and were reviewed. The follow-up periods ranged from 6 to 60 months. Amenorrhea rates for the NovaSure procedure ranged from 30.0% to 75.0%. Patients who reported being satisfied with the NovaSure procedure ranged from 85.0% to 94.0%. In randomized controlled trials with other global endometrial ablation modalities, amenorrhea rates at 12 months with the NovaSure procedure ranged from 43.0% to 56.0%, while other modalities ranged from 8% to 24%. In addition, this manuscript reviews the following: the NovaSure technology; use of the NovaSure procedure in the office setting; intraoperative and postoperative pain; effects on premenstrual syndrome (PMS; dysmenorrhea; special circumstances, including presence of uterine disease, history of cesarean delivery, coagulopathy, or use of anticoagulant medication; post-procedure uterine cavity assessment and cancer risk; contraception and pregnancy; and safety. Keywords: abnormal uterine bleeding, menorrhagia, endometrial ablation, NovaSure®

  15. Sobre el Grup de Sabadell y los Nova Novorum

    Directory of Open Access Journals (Sweden)

    Pego Puigbó, Armando

    2011-12-01

    Full Text Available In the present paper, from a comparative point of view, the literary roots of two of the most outstanding proposals for the renewal of the Spanish and Catalan narratives in the twenties and thirties are tried to describe. It is possible to find out the parallelisms between the work of Antonio Espina and Francesc Trabal in the dialogue with the aesthetical experience of the European vanguards to which they are linked by the narrative folly of their own contracdictions. Having in consideration the possibilities offered by the poem in prose or the microromance, similar responses could be traced between the «Grup of Sabadell» and the «Nova Novarum». In this way, Pájaro Pinto (1927 and Luna de copas (1929, by Espina, and L’ home que es va perdre (1929 or Judita (1939 by Trabal will be analyzed together.En el presente artículo se pretende describir, de manera comparada, las raíces literarias de dos de las propuestas más renovadoras de las narrativas española y catalana de los años veinte y treinta del siglo XX. Cabe buscar los posibles paralelismos entre la obra de Antonio Espina y Francesc Trabal en el diálogo con la experiencia estética de las vanguardias europeas en las que se insertaban y en la exasperación narrativa de sus propias contradicciones. Teniendo en cuenta las posiblilidades que ofrecía el poema en prosa o el microrrelato, será posible rastrear una similitud de respuestas que entrelaza la reflexión del «Grup de Sabadell» con la de los «Nova Novorum». A tal fin, se analizarán conjuntamente Pájaro Pinto (1927 y Luna de copas (1929, de Espina, y L’ home que es va perdre (1929 y Judita (1939 de Trabal.

  16. Novas tecnologias aplicadas às embalagens de alimentos

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    Flávia De Floriani Pozza Rebello

    2009-12-01

    Full Text Available Com o desenvolvimento da indústria de alimentos, as embalagens têm se aperfeiçoado, indo além de sua função básica de proteger o alimento contra danos mecânicos e contaminações químicas e microbiológicas. Elas têm cada vez mais desempenhando papel de destaque, contribuindo ativamente para a venda de um produto. Assim, as indústrias de embalagens têm procurado atender aos consumidores mais exigentes e juntamente aos centros de pesquisa e universidades, têm investido mais em estudos de novas tecnologias, a fim de prolongar as características de qualidade do alimento, conferir melhor aparência, maior proteção mecânica no embarque, transporte, desembarque e nos supermercados, oferecer embalagens mais compactas, que ocupem menos espaço na geladeira, com abertura e fechamento mais fáceis, e que utilizem materiais de fácil reciclagem ou decomposição no ambiente. Com o objetivo de atender às novas expectativas das indústrias de alimentos e dos consumidores, surgem as embalagens ativas e as embalagens inteligentes. As embalagens ativas são aquelas que interagem de alguma forma com o alimento, seja liberando substâncias conservantes ao longo da vida de prateleira do produto, ou “corrigindo” alguns problemas naturais do alimento, como sabor amargo por exemplo, em que algumas enzimas podem ser adicionadas ao material de embalagem, minimizando este problema e tornando o produto mais saboroso. Já as embalagens inteligentes indicam as modificações químicas às quais os alimentos estão passando, como mudanças de pH, por exemplo, indicando alterações na qualidade do produto.

  17. Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization

    OpenAIRE

    2008-01-01

    For many microRNAs, in many normal tissues and in cancer cells, the cellular levels of mature microRNAs are not simply determined by transcription of microRNA genes. This mini-review will discuss how microRNA biogenesis and function can be regulated by various nuclear and cytoplasmic processing events, including emerging evidence that microRNA pathway components can be selectively regulated by control of their subcellular localization and by modifications that occur during dynamic cellular si...

  18. MicroRNAs in Sjögren’s syndrome as a prototypic autoimmune disease

    OpenAIRE

    Alevizos, Ilias; Illei, Gabor G.

    2010-01-01

    MicroRNAs are endogenous non-coding RNAs, approximately 22 nucleotides in length. They regulate gene expression and are important in a wide range of physiological and pathological processes. MicroRNA expression is tightly regulated during hematopoiesis and lymphoid cell differentiation and disruption of the entire microRNA network or selected microRNAs may lead to dysregulated immune responses. Abnormalities in microRNA expression related to inflammatory cytokines, Th-17 and regulatory T cell...

  19. MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression

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    Pedro M. Costa

    2013-09-01

    Full Text Available The discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA stability and translation (and consequently protein synthesis has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs, an evolutionarily conserved class of small noncoding RNAs that regulate gene expression post-transcriptionally by base pairing to complementary sequences in the 3' untranslated regions of target mRNAs, are part of this modulatory RNA network playing a pivotal role in cell fate. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway, while changes in miRNA expression are associated with several human pathologies, including cancer. By targeting oncogenes and tumor suppressors, miRNAs have the ability to modulate key cellular processes that define the cell phenotype, making them highly promising therapeutic targets. Over the last few years, miRNA-based anti-cancer therapeutic approaches have been exploited, either alone or in combination with standard targeted therapies, aiming at enhancing tumor cell killing and, ideally, promoting tumor regression and disease remission. Here we provide an overview on the involvement of miRNAs in cancer pathology, emphasizing the mechanisms of miRNA regulation. Strategies for modulating miRNA expression are presented and illustrated with representative examples of their application in a therapeutic context.

  20. MicroRNAs associated with metastatic prostate cancer.

    Directory of Open Access Journals (Sweden)

    Akira Watahiki

    Full Text Available OBJECTIVE: Metastasis is the most common cause of death of prostate cancer patients. Identification of specific metastasis biomarkers and novel therapeutic targets is considered essential for improved prognosis and management of the disease. MicroRNAs (miRNAs form a class of non-coding small RNA molecules considered to be key regulators of gene expression. Their dysregulation has been shown to play a role in cancer onset, progression and metastasis, and miRNAs represent a promising new class of cancer biomarkers. The objective of this study was to identify down- and up-regulated miRNAs in prostate cancer that could provide potential biomarkers and/or therapeutic targets for prostate cancer metastasis. METHODS: Next generation sequencing technology was applied to identify differentially expressed miRNAs in a transplantable metastatic versus a non-metastatic prostate cancer xenograft line, both derived from one patient's primary cancer. The xenografts were developed via subrenal capsule grafting of cancer tissue into NOD/SCID mice, a methodology that tends to preserve properties of the original cancers (e.g., tumor heterogeneity, genetic profiles. RESULTS: Differentially expressed known miRNAs, isomiRs and 36 novel miRNAs were identified. A number of these miRNAs (21/104 have previously been reported to show similar down- or up-regulation in prostate cancers relative to normal prostate tissue, and some of them (e.g., miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis, supporting the validity of the analytical approach. CONCLUSIONS: The use of metastatic and non-metastatic prostate cancer subrenal capsule xenografts derived from one patient's cancer makes it likely that the differentially expressed miRNAs identified in this study include potential biomarkers and/or therapeutic targets for human prostate cancer metastasis.