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Sample records for microfabricated fountain pens

  1. Progression in the Fountain Pen Approach: From 2D Writing to 3D Free-Form Micro/Nanofabrication.

    Science.gov (United States)

    Je, Jung Ho; Kim, Jong-Man; Jaworski, Justyn

    2017-01-01

    The fountain pen approach, as a means for transferring materials to substrates, has shown numerous incarnations in recent years for creating 2D micro/nanopatterns and even generating 3D free-form nanostructures using a variety of material "inks". While the idea of filled reservoirs used to deliver material to a substrate via a capillary remains unchanged since antiquity, the advent of precise micromanipulation systems and functional material "inks" allows the extension of this mechanism to more high-tech applications. Herein, the recent growth in meniscus guided fountain pen approaches for benchtop micro/nanofabrication, which has occurred in the last decade, is discussed. Particular attention is given to the theory, equipment, and experimentation encompassing this unique direct writing approach. A detailed exploration of the diverse ink systems and functional device applications borne from this strategy is put forth to reveal its rapid expansion to a broad range of scientific and engineering disciplines. As such, this informative review is provided for researchers considering adoption of this recent advancement of a familiar technology.

  2. The analysis of fountain pen inks by capillary electrophoresis with ultraviolet/visible absorbance and laser-induced fluorescence detection.

    Science.gov (United States)

    Rohde, E; Vogt, C; Heineman, W R

    1998-01-01

    Information on the identity of inks adds to the circumstantial evidence in legal cases involving fraudulent documents. In combination with optical methods, multiple thin-layer chromatography (TLC) is currently the analytical tool used by forensic chemists to separate, compare and distinguish inks based on their dye composition. In our studies, capillary electrophoresis (CE) was used for the analysis of water-soluble fountain pen inks. Inks are complex mixtures of synthetic organic and inorganic dyes, surfactants, resins and other components. The investigations included the development of an electrophoretic separation method, the optimization of an extraction procedure for inks from paper as well as the evaluation of ultraviolet/visible (UV/VIS) absorbance and laser-induced fluorescence (LIF) detection for the analysis of inks by CE. Good results for the separation of 17 blue and black inks of different manufacturers and countries of origin were obtained with 100 mM borate buffer, pH 8.0, containing 20% methanol. The electropherograms of the inks and their extracts from paper showed patterns that were in most cases distinctly different from each other. Ultraviolet/visible scans can be used to compare spectra of the separated main and trace components of inks. Fluorescence detection at different excitation and emission wavelengths was more sensitive, but added to the complexity of the electropherograms due to the excitation of coextracted fluorescing paper components. The resolution power of CE combined with the information content provided by the detection modes investigated prove CE to be a powerful tool for the identification of water-soluble inks used on paper documents.

  3. Magic Fountain

    Institute of Scientific and Technical Information of China (English)

    AARON; A.VESSUP

    2011-01-01

    We’ve all heard the tales surrounding past legends of people motivated by special quests.King Arthur sought the holy grail,Christopher Columbus sought a magic way to India for riches,and Ponce de Leon searched for the fountain of youth.Fables,

  4. Molecular fountain.

    Energy Technology Data Exchange (ETDEWEB)

    Strecker, Kevin E.; Chandler, David W.

    2009-09-01

    A molecular fountain directs slowly moving molecules against gravity to further slow them to translational energies that they can be trapped and studied. If the molecules are initially slow enough they will return some time later to the position from which they were launched. Because this round trip time can be on the order of a second a single molecule can be observed for times sufficient to perform Hz level spectroscopy. The goal of this LDRD proposal was to construct a novel Molecular Fountain apparatus capable of producing dilute samples of molecules at near zero temperatures in well-defined user-selectable, quantum states. The slowly moving molecules used in this research are produced by the previously developed Kinematic Cooling technique, which uses a crossed atomic and molecular beam apparatus to generate single rotational level molecular samples moving slowly in the laboratory reference frame. The Kinematic Cooling technique produces cold molecules from a supersonic molecular beam via single collisions with a supersonic atomic beam. A single collision of an atom with a molecule occurring at the correct energy and relative velocity can cause a small fraction of the molecules to move very slowly vertically against gravity in the laboratory. These slowly moving molecules are captured by an electrostatic hexapole guiding field that both orients and focuses the molecules. The molecules are focused into the ionization region of a time-of-flight mass spectrometer and are ionized by laser radiation. The new molecular fountain apparatus was built utilizing a new design for molecular beam apparatus that has allowed us to miniaturize the apparatus. This new design minimizes the volumes and surface area of the machine allowing smaller pumps to maintain the necessary background pressures needed for these experiments.

  5. Molecular Fountain

    Science.gov (United States)

    Cheng, Cunfeng; van der Poel, Aernout P. P.; Jansen, Paul; Quintero-Pérez, Marina; Wall, Thomas E.; Ubachs, Wim; Bethlem, Hendrick L.

    2016-12-01

    The resolution of any spectroscopic or interferometric experiment is ultimately limited by the total time a particle is interrogated. Here we demonstrate the first molecular fountain, a development which permits hitherto unattainably long interrogation times with molecules. In our experiments, ammonia molecules are decelerated and cooled using electric fields, launched upwards with a velocity between 1.4 and 1.9 m/s and observed as they fall back under gravity. A combination of quadrupole lenses and bunching elements is used to shape the beam such that it has a large position spread and a small velocity spread (corresponding to a transverse temperature of free fall, while being strongly focused at the detection region. The molecules are in free fall for up to 266 ms, making it possible, in principle, to perform sub-Hz measurements in molecular systems and paving the way for stringent tests of fundamental physics theories.

  6. Carbon Dioxide Fountain

    Science.gov (United States)

    Kang, Seong-Joo; Ryu, Eun-Hee

    2007-01-01

    This article presents the development of a carbon dioxide fountain. The advantages of the carbon dioxide fountain are that it is odorless and uses consumer chemicals. This experiment also is a nice visual experiment that allows students to see evidence of a gaseous reagent being consumed when a pressure sensor is available. (Contains 3 figures.)…

  7. The USNO rubidium fountains

    CERN Document Server

    Peil, Steven; Swanson, Thomas B; Taylor, Jennifer; Ekstrom, Christopher R

    2016-01-01

    Four rubidium fountains at the U.S. Naval Observatory (USNO) have been in operation for 4.5 years. Each fountain has demonstrated periods of stability marked by Total or Theo deviation below 10^-16. Occasional frequency changes, on order of 1.5 times per year per fountain, introduce deviations from white-frequency noise behavior. Averaged together, the four fountains form an ensemble with a white-frequency noise level of 10^-13 and excellent long-term stability as compared to the primary frequency standards contributing to TAI. Progress on using the clocks at USNO for improving limits on coupling of fundamental constants to gravity by measuring the universality of the gravitational redshift for different types of clocks is discussed.

  8. [Misting-fountain-alveolitis].

    Science.gov (United States)

    Koschel, D; Sennekamp, J; Schurz, C; Müller-Wening, D

    2004-09-01

    A 22-year-old woman developed recurrent episodes of fever, cough and dyspnea after repeated exposure to a misting fountain at home. A diagnosis of extrinsic allergic alveolitis (EAA) was made by detection of serum antibodies against the fountain water, by culture of Bacillus subtilis, Mucor racemosus, Mucor mucedo, and Saccharomyces cerevisiae from the water, and by detection of specific IgG antibodies against Bacillus subtilis and the Mucores. The diagnosis was confirmed by a restrictive lung function pattern, and a highly increased total cell count with a lymphocytosis of 39 % in the bronchoalveolar lavage. An inhalation challenge with the misting fountain resulted in a positive reaction. Because this humidifier system has recently become widespread at home, clinicians should be aware of this specific type of EAA which may be called "misting fountain alveolitis".

  9. Microfabricated thermionic detector

    Science.gov (United States)

    Lewis, Patrick R; Manginell, Ronald P; Wheeler, David R; Trudell, Daniel E

    2012-10-30

    A microfabricated TID comprises a microhotplate and a thermionic source disposed on the microhotplate. The microfabricated TID can provide high sensitivity and selectivity to nitrogen- and phosphorous-containing compounds and other compounds containing electronegative function groups. The microfabricated TID can be microfabricated with semiconductor-based materials. The microfabricated TID can be combined with a microfabricated separation column and used in microanalytical system for the rapid on-site detection of pesticides, chemical warfare agents, explosives, pharmaceuticals, and other organic compounds that contain nitrogen or phosphorus.

  10. Understanding the Chain Fountain

    CERN Document Server

    Biggins, John Simeon

    2013-01-01

    If a chain is initially at rest in a beaker at a height h1 above the ground, and the end of the chain is pulled over the rim of the beaker and down towards the ground and then released, the chain will spontaneously "flow" out of the beaker under gravity. Furthermore, if h1 is sufficient, the beads do not simply drag over the edge of the beaker but form a fountain reaching a height h2 above it. We show that the formation of a fountain requires that the beads come into motion not only by being pulled upwards by the part of the chain immediately above the pile, but also by being pushed upwards by an anomalous reaction force from the pile of stationary chain. We propose possible origins for this force, argue that its magnitude will be proportional to the square of the chain velocity, and predict and verify experimentally that h2 is proportional to h1.

  11. Introduction to microfabrication

    CERN Document Server

    Franssila, Sami

    2005-01-01

    Microfabrication is the key technology behind integrated circuits, microsensors, photonic crystals, ink jet printers, solar cells and flat panel displays. Microsystems can be complex, but the basic microstructures and processes of microfabrication are fairly simple. Introduction to Microfabrication shows how the common microfabrication concepts can be applied over and over again to create devices with a wide variety of structures and functions.Featuring:* A comprehensive presentation of basic fabrication processes* An emphasis on materials and microstructures, rather than devic

  12. Short Global History of Fountains

    Directory of Open Access Journals (Sweden)

    Petri S. Juuti

    2015-05-01

    Full Text Available Water fountains are part of every human settlement, and historical and mythological stories. They are the source from which life-sustaining water was distributed to people until piped systems started providing fresh tap water inside buildings. In many places, people visit fountains to experience the freshness of running water, to prepare for prayers, or to make a wish. Fountains have also provided water for the people of cities under siege, and purified believers as part of holy rites. The Castalia shrine in Delphi, Greece, for its part, is a spot where various groups of people come to socialize, which greatly improves the quality of their lives. This paper is a look back through the history of fountains in various parts of the world. Experts from various areas have identified the historic, cultural, and ritualistic aspects of fountains and their findings are summarized. The paper concludes by providing a glimpse into the role of fountains in modern society and their continued influence in our lives today.

  13. a Molecular Fountain

    Science.gov (United States)

    Cheng, Cunfeng; van der Poel, Aernout P. P.; Ubachs, Wim; Bethlem, Hendrick

    2017-06-01

    The resolution of any spectroscopic experiment is limited by the coherent interaction time between the probe radiation and the particle that is being studied. The introduction of cooling techniques for atoms and ions has resulted in a dramatic increase of interaction times and accuracy, it is hoped that molecular cooling techniques will lead to a similar increase. Here we demonstrate the first molecular fountain, a development which permits hitherto unattainably long interrogation times with molecules. In our experiment, beams of ammonia molecules are decelerated, trapped and cooled using inhomogeneous electric fields and subsequently launched. Using a combination of quadrupole lenses and buncher elements, the beam is shaped such that it has a large position spread and a small velocity spread (corresponding to a transverse temperature of less than 10μK and a longitudinal temperature of less than 1μK) while the molecules are in free fall, but strongly focused at the detection region. The molecules are in free fall for up to 266 milliseconds, making it possible, in principle, to perform sub-Hz measurements in molecular systems and paving the way for stringent tests of fundamental physics theories.

  14. A molecular fountain

    CERN Document Server

    Cheng, Cunfeng; Jansen, Paul; Quintero-Pérez, Marina; Wall, Thomas E; Ubachs, Wim; Bethlem, Hendrick L

    2016-01-01

    The resolution of any spectroscopic or interferometric experiment is ultimately limited by the total time a particle is interrogated. We here demonstrate the first molecular fountain, a development which permits hitherto unattainably long interrogation times with molecules. In our experiments, ammonia molecules are decelerated and cooled using electric fields, launched upwards with a velocity between 1.4 and 1.9\\,m/s and observed as they fall back under gravity. A combination of quadrupole lenses and bunching elements is used to shape the beam such that it has a large position spread and a small velocity spread (corresponding to a transverse temperature of $<$10\\,$\\mu$K and a longitudinal temperature of $<$1\\,$\\mu$K) when the molecules are in free fall, while being strongly focused at the detection region. The molecules are in free fall for up to 266\\,milliseconds, making it possible to perform sub-Hz measurements in molecular systems and paving the way for stringent tests of fundamental physics theorie...

  15. Fountain pen nanochemistry: Atomic force control of chrome etching

    Science.gov (United States)

    Lewis, Aaron; Kheifetz, Yuri; Shambrodt, Efim; Radko, Anna; Khatchatryan, Edward; Sukenik, Chaim

    1999-10-01

    In this report we demonstrate a general method for affecting chemical reactions with a high degree of spatial control that has potentially wide applicability in science and technology. Our technique is based on complexing the delivery of liquid or gaseous materials through a cantilevered micropipette with an atomic force microscope that is totally integrated into a conventional optical microscope. Controlled etching of chrome is demonstrated without detectable effects on the underlying glass substrate. This simple combination allows for the nanometric spatial control of the whole world of chemical reactions in defined regions of surfaces. Applications of the technique in critical areas such as mask repair are likely.

  16. Neutral hydrogen in galactic fountains

    CERN Document Server

    Booth, C M

    2007-01-01

    Simulations of an isolated Milky Way-like galaxy, in which supernovae power a galactic fountain, reproduce the observed velocity and 21cm brightness statistics of galactic neutral hydrogen (HI). The simulated galaxy consists of a thin HI disk, similar in extent and brightness to that observed in the Milky Way, and extra-planar neutral gas at a range of velocities due to the galactic fountain. Mock observations of the neutral gas resemble the HI flux measurements from the Leiden-Argentine-Bonn (LAB) HI, survey, including a high-velocity tail which matches well with observations of high-velocity clouds. The simulated high-velocity clouds are typically found close to the galactic disk, with a typical line-of-sight distance of 13kpc from observers on the solar circle. The fountain efficiently cycles matter from the centre of the galaxy to its outskirts at a rate of around 0.5 M_sun/yr

  17. Microfabricated Waveguide Atom Traps.

    Energy Technology Data Exchange (ETDEWEB)

    Jau, Yuan-Yu

    2017-09-01

    A nano - scale , microfabricated waveguide structure can in - principle be used to trap atoms in well - defined locations and enable strong photon - atom interactions . A neutral - atom platf orm based on this microfabrication technology will be pre - aligned , which is especially important for quantum - control applications. At present, there is still no reported demonstration of evanescent - field atom trapping using a microfabricated waveguide structure. We described the capabilities established by our team for future development of the waveguide atom - trapping technology at SNL and report our studies to overcome the technical challenges of loading cold atoms into the waveguide atom traps, efficient and broadband optical coupling to a waveguide, and the waveguide material for high - power optical transmission. From the atomic - physics and the waveguide modeling, w e have shown that a square nano - waveguide can be utilized t o achieve better atomic spin squeezing than using a nanofiber for first time.

  18. Microfabricated ion trap array

    Science.gov (United States)

    Blain, Matthew G.; Fleming, James G.

    2006-12-26

    A microfabricated ion trap array, comprising a plurality of ion traps having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale ion traps to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The reduced electrode voltage enables integration of the microfabricated ion trap array with on-chip circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of the microfabricated ion trap array can be realized in truly field portable, handheld microanalysis systems.

  19. Progress of the ~(87)Rb Fountain Clock

    Institute of Scientific and Technical Information of China (English)

    ZHOU Zi-Chao; WEI Rong; SHI Chun-Yan; LV De-Sheng; LI Tang; WANG Yu-Zhu

    2009-01-01

    A fountain atomic clock based on cold ~(87)Rb atoms has been in operation in our laboratory for several months.We therefore report the design of the rubidium fountain clock including its physical package,optical system and daily operation.Ramsey fringes have been attained with the signal to noise ratio of about 100.

  20. Theory of Adiabatic Fountain Resonance

    Science.gov (United States)

    Williams, Gary A.

    2017-01-01

    The theory of "Adiabatic Fountain Resonance" with superfluid ^4{He} is clarified. In this geometry a film region between two silicon wafers bonded at their outer edge opens up to a central region with a free surface. We find that the resonance in this system is not a Helmholtz resonance as claimed by Gasparini et al., but in fact is a fourth sound resonance. We postulate that it occurs at relatively low frequency because the thin silicon wafers flex appreciably from the pressure oscillations of the sound wave.

  1. Introduction to microfabrication

    CERN Document Server

    Franssila, Sami

    2010-01-01

    This accessible text is now fully revised and updated, providing an overview of fabrication technologies and materials needed to realize modern microdevices. It demonstrates how common microfabrication principles can be applied in different applications, to create devices ranging from nanometer probe tips to meter scale solar cells, and a host of microelectronic, mechanical, optical and fluidic devices in between. Latest developments in wafer engineering, patterning, thin films, surface preparation and bonding are covered. This second edition includes:expanded sections on MEMS

  2. Laser precision microfabrication

    CERN Document Server

    Sugioka, Koji; Pique, Alberto

    2010-01-01

    Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.

  3. An all-at-once factorial method to optimize dip-pen deposition of liquid protein inks

    Science.gov (United States)

    Henning, A. K.; Rozhok, S.; Fragala, J.; Shile, R.; Ouyang, K.

    2013-03-01

    An all-at-once factorial method is presented, which optimizes protein ink deposition using microfabricated pens by identifying the pen design which writes the greatest number of uniform-size spots or droplets without re-inking. Pen features associated with capillary ink transport are varied according to statistical design-of-experiment (SDOE) principles, and evaluated using a special 1D pen array of twelve pens. Variable parameter pens are bracketed by control pens. Each pen array element embodies one component of the SDOE matrix. All parameters are evaluated simultaneously with a single droplet writing pass. Results can also be evaluated simultaneously, leading to rapid choice of those pen parameters which deliver the greatest number of printed features having the smallest coefficient of variation.

  4. Microfabricated Formaldehyde Gas Sensors

    Directory of Open Access Journals (Sweden)

    Karen C. Cheung

    2009-11-01

    Full Text Available Formaldehyde is a volatile organic compound that is widely used in textiles, paper, wood composites, and household materials. Formaldehyde will continuously outgas from manufactured wood products such as furniture, with adverse health effects resulting from prolonged low-level exposure. New, microfabricated sensors for formaldehyde have been developed to meet the need for portable, low-power gas detection. This paper reviews recent work including silicon microhotplates for metal oxide-based detection, enzyme-based electrochemical sensors, and nanowire-based sensors. This paper also investigates the promise of polymer-based sensors for low-temperature, low-power operation.

  5. Fountain Codes: LT And Raptor Codes Implementation

    Directory of Open Access Journals (Sweden)

    Ali Bazzi, Hiba Harb

    2017-01-01

    Full Text Available Digital fountain codes are a new class of random error correcting codes designed for efficient and reliable data delivery over erasure channels such as internet. These codes were developed to provide robustness against erasures in a way that resembles a fountain of water. A digital fountain is rateless in a way that sender can send limitless number of encoded packets. The receiver doesn’t care which packets are received or lost as long as the receiver gets enough packets to recover original data. In this paper, the design of the fountain codes is explored with its implementation of the encoding and decoding algorithm so that the performance in terms of encoding/decoding symbols, reception overhead, data length, and failure probability is studied.

  6. Cesium Atomic Fountain Clocks at NMIJ

    Science.gov (United States)

    2010-11-01

    Wynands and S. Weyers, 2005, “Atomic fountain clocks,” Metrologia , 42, S64-S79. [2] M. Takamoto, F. L. Hong, R. Higashi, et al., 2005, “An optical...beam of laser-cooled cesium atoms,” Physical Review, A 60, R4241-R4244. [13] V. Gerginov, N. Nemitz, S. Weyers, et al., 2010, “Uncertainty evaluation of the caesium fountain clock PTB-CSF2,” Metrologia , 47, 65-79.

  7. Silicon microfabricated beam expander

    Science.gov (United States)

    Othman, A.; Ibrahim, M. N.; Hamzah, I. H.; Sulaiman, A. A.; Ain, M. F.

    2015-03-01

    The feasibility design and development methods of silicon microfabricated beam expander are described. Silicon bulk micromachining fabrication technology is used in producing features of the structure. A high-precision complex 3-D shape of the expander can be formed by exploiting the predictable anisotropic wet etching characteristics of single-crystal silicon in aqueous Potassium-Hydroxide (KOH) solution. The beam-expander consist of two elements, a micromachined silicon reflector chamber and micro-Fresnel zone plate. The micro-Fresnel element is patterned using lithographic methods. The reflector chamber element has a depth of 40 µm, a diameter of 15 mm and gold-coated surfaces. The impact on the depth, diameter of the chamber and absorption for improved performance are discussed.

  8. Microfabricated ion frequency standard

    Science.gov (United States)

    Schwindt, Peter; Biedermann, Grant; Blain, Matthew G.; Stick, Daniel L.; Serkland, Darwin K.; Olsson, III, Roy H.

    2010-12-28

    A microfabricated ion frequency standard (i.e. an ion clock) is disclosed with a permanently-sealed vacuum package containing a source of ytterbium (Yb) ions and an octupole ion trap. The source of Yb ions is a micro-hotplate which generates Yb atoms which are then ionized by a ultraviolet light-emitting diode or a field-emission electron source. The octupole ion trap, which confines the Yb ions, is formed from suspended electrodes on a number of stacked-up substrates. A microwave source excites a ground-state transition frequency of the Yb ions, with a frequency-doubled vertical-external-cavity laser (VECSEL) then exciting the Yb ions up to an excited state to produce fluorescent light which is used to tune the microwave source to the ground-state transition frequency, with the microwave source providing a precise frequency output for the ion clock.

  9. Silicon microfabricated beam expander

    Energy Technology Data Exchange (ETDEWEB)

    Othman, A., E-mail: aliman@ppinang.uitm.edu.my; Ibrahim, M. N.; Hamzah, I. H.; Sulaiman, A. A. [Faculty of Electrical Engineering, Universiti Teknologi MARA Malaysia, 40450, Shah Alam, Selangor (Malaysia); Ain, M. F. [School of Electrical and Electronic Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300,Nibong Tebal, Pulau Pinang (Malaysia)

    2015-03-30

    The feasibility design and development methods of silicon microfabricated beam expander are described. Silicon bulk micromachining fabrication technology is used in producing features of the structure. A high-precision complex 3-D shape of the expander can be formed by exploiting the predictable anisotropic wet etching characteristics of single-crystal silicon in aqueous Potassium-Hydroxide (KOH) solution. The beam-expander consist of two elements, a micromachined silicon reflector chamber and micro-Fresnel zone plate. The micro-Fresnel element is patterned using lithographic methods. The reflector chamber element has a depth of 40 µm, a diameter of 15 mm and gold-coated surfaces. The impact on the depth, diameter of the chamber and absorption for improved performance are discussed.

  10. Microfabricated triggered vacuum switch

    Science.gov (United States)

    Roesler, Alexander W.; Schare, Joshua M.; Bunch, Kyle

    2010-05-11

    A microfabricated vacuum switch is disclosed which includes a substrate upon which an anode, cathode and trigger electrode are located. A cover is sealed over the substrate under vacuum to complete the vacuum switch. In some embodiments of the present invention, a metal cover can be used in place of the trigger electrode on the substrate. Materials used for the vacuum switch are compatible with high vacuum, relatively high temperature processing. These materials include molybdenum, niobium, copper, tungsten, aluminum and alloys thereof for the anode and cathode. Carbon in the form of graphitic carbon, a diamond-like material, or carbon nanotubes can be used in the trigger electrode. Channels can be optionally formed in the substrate to mitigate against surface breakdown.

  11. Growth and Shape of a Chain Fountain

    CERN Document Server

    Biggins, John S

    2014-01-01

    If a long chain is held in a pot elevated a distance h_1 above the floor, and the end of the chain is then dragged over the rim of the pot and released, the chain flows under gravity down into a pile on the floor. Not only does the chain flow out of the pot, it also leaps above the pot in a "chain-fountain". I predict and observe that if the pot is held at an angle to the vertical the steady state shape of the fountain is an inverted catenary, and discuss how to apply boundary conditions to this solution. In the case of a level pot, the fountain shape is completely vertical. In this case I predict and observe both how fast the fountain grows to its steady state hight, and how it grows quadratically in time if there is no floor. The fountain is driven by an anomalous push force from the pot that acts on the link of chain about to come into motion. I confirm this by designing two new chains, one consisting of hollow cylinders threaded on a string and one consisting of heavy beads separated by long flexible thre...

  12. Is there a stratospheric fountain?

    Directory of Open Access Journals (Sweden)

    J.-P. Pommereau

    2007-06-01

    by irreversible mixing of convective overshoots as proposed by Danielsen (1982 do not appear as episodic isolated features, but common and systematic events over a land convective area, that is a Stratospheric Fountain. Though the two-stages process proposed by Sherwood (2000 may also be operative, it offers a mechanism for producing the chemical, moisture and thermal properties observed in the stratosphere. The consistency between convective cooling of the TTL and weather radar echoes heights observed during the summer over South-East Brazil and the TRMM radar OPFs and LIS lightning events maximum frequencies, the latter showing also maximum events over Africa, South-East Asia, the Indonesian Islands and Northern Australia depending on the season (Liu and Zipser, 2005, suggests the existence of several "Stratospheric Fountains" over continents instead of the oceanic area of Micronesia as proposed by Newell and Gould-Stewart (1982, which appears a region of little overshoot.

  13. Extrinsic allergic alveolitis caused by misting fountains.

    Science.gov (United States)

    Koschel, Dirk; Stark, Wolfram; Karmann, Fritz; Sennekamp, Jochen; Müller-Wening, Dietrich

    2005-08-01

    Recently, an increasing number of patients were presented to our clinics with febrile and respiratory symptoms associated with exposure to a new type of domestic ultrasonic humidifier. We report on 11 patients who developed recurrent episodes of fever, cough and dyspnea after repeated exposure to ultrasonic misting fountains at home. A diagnosis of extrinsic allergic alveolitis (EAA) or toxic alveolitis was made on the basis of the history and the clinical, radiological, laboratory and immunological findings. Eight patients were subjected to inhalative challenge tests with their own ultrasonic misting fountains, and all of them exhibited positive reactions. Nine patients were diagnosed with an EAA (humidifier lung) and two patients with a toxic alveolitis (humidifier fever). This study demonstrates the potential for ultrasonic misting fountains to cause illness in the home. In view of the increasing popularity of these devices, humidifier lung and humidifier fever should be considered in the differential diagnosis of patients with unexplained pulmonary or flu-like illnesses with fever.

  14. Legionellosis Outbreak Associated With a Hotel Fountain.

    Science.gov (United States)

    Smith, Shamika S; Ritger, Kathy; Samala, Usha; Black, Stephanie R; Okodua, Margaret; Miller, Loretta; Kozak-Muiznieks, Natalia A; Hicks, Lauri A; Steinheimer, Craig; Ewaidah, Saadeh; Presser, Lance; Siston, Alicia M

    2015-12-01

    Background.  In August 2012, the Chicago Department of Public Health (CDPH) was notified of acute respiratory illness, including 1 fatality, among a group of meeting attendees who stayed at a Chicago hotel during July 30-August 3, 2012. Suspecting Legionnaires' disease (LD), CDPH advised the hotel to close their swimming pool, spa, and decorative lobby fountain and began an investigation. Methods.  Case finding included notification of individuals potentially exposed during July 16-August 15, 2012. Individuals were interviewed using a standardized questionnaire. An environmental assessment was performed. Results.  One hundred fourteen cases were identified: 11 confirmed LD, 29 suspect LD, and 74 Pontiac fever cases. Illness onsets occurred July 21-August 22, 2012. Median age was 48 years (range, 22-82 years), 64% were male, 59% sought medical care (15 hospitalizations), and 3 died. Relative risks for hotel exposures revealed that persons who spent time near the decorative fountain or bar, both located in the lobby were respectively 2.13 (95%, 1.64-2.77) and 1.25 (95% CI, 1.09-1.44) times more likely to become ill than those who did not. Legionella pneumophila serogroup 1 was isolated from samples collected from the fountain, spa, and women's locker room fixtures. Legionella pneumophila serogroup 1 environmental isolates and a clinical isolate had matching sequence-based types. Hotel maintenance records lacked a record of regular cleaning and disinfection of the fountain. Conclusions.  Environmental testing identified Legionella in the hotel's potable water system. Epidemiologic and laboratory data indicated the decorative fountain as the source. Poor fountain maintenance likely created favorable conditions for Legionella overgrowth.

  15. Miniaturized optical system for atomic fountain clock

    Institute of Scientific and Technical Information of China (English)

    Lü De-Sheng; Qu Qiu-Zhi; Wang Bin; Zhao Jian-Bo; Li Tang; Liu Liang; Wang Yu-Zhu

    2011-01-01

    Using modularized components, we have built a miniaturized optical system for 87Rb atomic fountain clock that is fitted on an 80 cm × 60 cm optical breadboard. Compared with the conventional optical setup on the table, our system is more compact, more robust and miniaturized. Taking advantage of this system, laser beams are transmitted through eight optical fibre patch cords from the optical breadboard to an ultra high vacuum system. This optical setup has operated for five months in our fountain system and required no alignment.

  16. 3D microfabrication technology

    Science.gov (United States)

    Tang, Esheng; FuTing, Yi; Tian, Yangchao; Liang, Jingqiu; Xian, Dingchang

    1998-08-01

    In the late of this century the great success of VSIC impacts into almost every fields of our social. Following this idea people starts to integrate microsensor microprocessor and microactuators into a small space to forming a Micro Electro and Mechanical System. Such small robot parts are applied to including satellites, computer communication, medical, chemical, biological and environment and so on research fields. The development of MEMS would strongly influence industrial revolution in the next century. LIGA technology including X-ray deep etching lithography; electroplating and plastic molding developed by Karlsruhe Nuclear Research Center, Germany since the beginning of 1980. Its advantages are: it could make three-dimensional microstructures with lateral dimension in several micron range and thickness of several hundred microns with sub-micron precision. In principle all kinds of materials such as polymer, metal and ceramic could be used as microcomponents and could be mass- produced by plastic molding to a commercially available fabrication. LIGA process has become one of the most promising Microfabrication technologies for producing micromechanical, microfluid and micro-optical elements. It opens an additional field in the microstructure market.

  17. Fountains and water culture in Byzantium

    NARCIS (Netherlands)

    Shilling, B.L.; Stephenson, P.A.

    2016-01-01

    This book restores the fountains of Roman Byzantium, Byzantine Constantinople and Ottoman Istanbul, reviving the sounds, shapes, smells and sights of past water cultures. Constantinople, the capital of the Byzantine and Ottoman Empires, is surrounded on three sides by sea, and has no major river to

  18. Microfabrication of Laser-Driven Accelerator Structures

    Energy Technology Data Exchange (ETDEWEB)

    Cowan, Benjamin M

    2003-04-07

    We discuss the potential for using microfabrication techniques for laser-driven accelerator construction. We introduce microfabrication processes in general, and then describe our investigation of a particular trial process. We conclude by considering the issues microfabrication raises for possible future structures.

  19. Computer Aided Design System for Developing Musical Fountain Programs

    Institute of Scientific and Technical Information of China (English)

    刘丹; 张乃尧; 朱汉城

    2003-01-01

    A computer aided design system for developing musical fountain programs was developed with multiple functions such as intelligent design, 3-D animation, manual modification and synchronized motion to make the development process more efficient. The system first analyzed the music form and sentiment using many basic features of the music to select a basic fountain program. Then, this program is simulated with 3-D animation and modified manually to achieve the desired results. Finally, the program is transformed to a computer control program to control the musical fountain in time with the music. A prototype system for the musical fountain was also developed. It was tested with many styles of music and users were quite satisfied with its performance. By integrating various functions, the proposed computer aided design system for developing musical fountain programs greatly simplified the design of the musical fountain programs.

  20. Can soda fountains be recommended in hospitals?

    Science.gov (United States)

    Chaberny, Iris F; Kaiser, Peter; Sonntag, Hans-Günther

    2006-09-01

    Mineral water (soda water) is very popular in Germany. Therefore, soda fountains were developed as alternatives to the traditional deposit bottle system. Nowadays, different systems of these devices are commercially available. For several years, soda fountains produced by different companies have been examined at the University Hospital of Heidelberg. In 1998, it was possible for the first time to observe and evaluate one of these systems over a period of 320 days in a series of microbiological examinations. The evaluation was implemented on the basis of the German drinking water regulation (Anonymous, 1990. Gesetz über Trinkwasser und Wasser für Lebensmittelbetriebe (Trinkwasserverordnung - TrinkwV) vom 12. Dezember 1990. Bundesgesetzblatt 66, 2613ff). Initially, the bacteria counts exceeded the reference values imposed by the German drinking water regulation in almost 50% of the analyses. Pseudomonas aeruginosa was also detected in almost 38% of the samples. After a re-arrangement of the disinfection procedure and the removal of the charcoal filter, Pseudomonas aeruginosa was not detectable any more. However, the bacteria counts still frequently exceeded the reference values of the German drinking water regulation. Following our long-term analysis, we would not recommend soda fountains in high-risk areas of hospitals. If these devices are to be used in hospitals, the disinfection procedures should be executed in weekly or fortnightly intervals and the water quality should be examined periodically.

  1. Evaluation of Long Term Performance of Continuously Running Atomic Fountains

    Science.gov (United States)

    2014-05-28

    Observatory (USNO). These fountains are used as continuous clocks in the manner of commercial caesium beams and hydrogen masers for the purpose of improved...clock, rubidium fountain, operational atomic fountain (Some figures may appear in colour only in the online journal) 1. Introduction: beyond caesiums ...and masers The performance of atomic clocks has improved more than seven orders of magnitude since the first caesium clock was demonstrated by Essen

  2. Fountain Codes with Multiplicatively Repeated Non-Binary LDPC Codes

    CERN Document Server

    Kasai, Kenta

    2010-01-01

    We study fountain codes transmitted over the binary-input symmetric-output channel. For channels with small capacity, receivers needs to collects many channel outputs to recover information bits. Since a collected channel output yields a check node in the decoding Tanner graph, the channel with small capacity leads to large decoding complexity. In this paper, we introduce a novel fountain coding scheme with non-binary LDPC codes. The decoding complexity of the proposed fountain code does not depend on the channel. Numerical experiments show that the proposed codes exhibit better performance than conventional fountain codes, especially for small number of information bits.

  3. Three-Dimensional Evolution of the Galactic Fountain

    CERN Document Server

    D'Avillez, M A

    1999-01-01

    Gas that escapes from the Galactic disk, rises into the halo, cools and falls back, constitutes a "Galactic Fountain". Three-Dimensional simulations show that such a fountain model reproduces many of the features that have been observed in the Galaxy and other galaxies such as M31 and M33. Here, these results are reported.

  4. Evaluation of Long Term Performance of Continuously Running Atomic Fountains

    CERN Document Server

    Peil, Steven; Swanson, Thomas B; Taylor, Jennifer; Ekstrom, Christopher R

    2014-01-01

    An ensemble of rubidium atomic fountain clocks has been put into operation at the U.S. Naval Observatory (USNO). These fountains are used as continuous clocks in the manner of commercial cesium beams and hydrogen masers for the purpose of improved timing applications. Four fountains have been in operation for more than two years and are included in the ensemble used to generate the USNO master clock. Individual fountain performance is characterized by a white-frequency noise level below $2\\times 10^{-13}$ and fractional-frequency stability routinely reaching the low $10^{-16}$s. The highest performing pair of fountains exhibits stability consistent with each fountain integrating as white frequency noise, with Allan deviation surpassing $6\\times 10^{-17}$ at $10^7$~s, and with no relative drift between the fountains at the level of $7.5 \\times 10^{-19}$/day. As an ensemble, the fountains generate a timescale with white-frequency noise level of $1\\times 10^{-13}$ and long-term frequency stability consistent wit...

  5. Simulation of the formation and characteristics of ultrasonic fountain.

    Science.gov (United States)

    Xu, Zheng; Yasuda, Keiji; Liu, Xiaojun

    2016-09-01

    In order to design an ultrasonic apparatus with a high throughput rate for generating atomization, the mechanism of fountain characteristics is important because the throughput rate of the ultrasonic atomization is decided by the area of the fountain surface. The formation of the fountain can be numerically studied by taking into account the effect of surface tension and radiation pressure. We have investigated the shape of the fountain with different ultrasound parameters or different kinds of solutions. When the amplitude of input sound pressure is higher than 1.3×10(5)Pa, the liquid separates from the ultrasonic fountain after irradiation for a very short period. It is further found that the area of the fountain surface increases with the concentration of the ethanol due to its low surface tension, density and sound speed. Finally, we discuss the difference between the ultrasonic fountain and the pump fountain, and find that the velocity field in the reactor induced by the pump is higher than that by the ultrasound.

  6. Fountain-Gould Left Orders for Associative Pairs

    Institute of Scientific and Technical Information of China (English)

    José A. ANQUELA; Teresa CORT(E)S; Miguel G(O)MEZ LOZANO; Mercedes SILES MOLINA

    2006-01-01

    In this paper, we introduce a notion of weak Fountain-Gould left order for associative pairs and give a Goldie-like theory of associative pairs which are weak Fountain-Gould left orders in semiprime pairs coinciding with their socles.

  7. Optical Stabilization of a Microwave Oscillator for Fountain Clock Interrogation

    CERN Document Server

    Lipphardt, Burghard; Weyers, Stefan

    2016-01-01

    We describe an optical frequency stabilization scheme of a microwave oscillator that is used for the interrogation of primary caesium fountain clocks. Because of its superior phase noise properties, the new scheme, which is based on an ultrastable laser and a femtosecond laser frequency comb, overcomes the fountain clock frequency instability limitations given by the previously utilized quartz oscillator based frequency synthesis. The presented scheme combines the transfer of the short-term frequency instability of an optical cavity and the long-term frequency instability of a hydrogen maser to the microwave oscillator and is designed to provide continuous long-term operation for extended measurement periods of weeks. The utilization of the twofold stabilization scheme on the one hand ensures referencing of the fountain frequency to the hydrogen maser frequency and on the other hand results in a phase noise level of the fountain interrogation signal, which enables quantum projection noise limited fountain fre...

  8. SUPERNOVA EXPLOSIONS AND THE TRIGGERING OF GALACTIC FOUNTAINS AND OUTFLOWS

    Directory of Open Access Journals (Sweden)

    E. M. de Gouveia Dal Pino

    2009-01-01

    the gas in the fountains. Due to angular momentum losses (of 10¿15% to the halo, we find that the fountain material falls back to smaller radii and is not largely spread over the galactic disk, as previously expected, but falls near the region where the fountain was produced This result is consistent with the metal distribution derived from recent chemical models of the galaxy. We also find that after about 150 Myr, the gas circulation between the halo and the disk in the fountains reaches a steady state regime, and this is relatively insensitive to the galacto-centric distance where the fountains are produced. The fall back material leads to the formation of new generations of complex structures that help to feed the supersonic turbulence in the disk.

  9. Penning trap at IGISOL

    Energy Technology Data Exchange (ETDEWEB)

    Szerypo, J. E-mail: jerzy.szerypo@phys.jyu.fi; Jokinen, A.; Kolhinen, V.S.; Nieminen, A.; Rinta-Antila, S.; Aeystoe, J

    2002-04-22

    The IGISOL facility at the Department of Physics of the University of Jyvaeskylae (JYFL) is delivering radioactive beams of short-lived exotic nuclei, in particular the neutron-rich isotopes from the fission reaction. These nuclei are studied with the nuclear spectroscopy methods. In order to substantially increase the quality and sensitivity of such studies, the beam should undergo beam handling: cooling, bunching and isobaric purification. The first two processes are performed with the use of an RFQ cooler/buncher. The isobaric purification will be made by a Penning trap placed after the RF-cooler element. This contribution describes the current status of the Penning trap project and its future prospects. The latter comprise the precise nuclear mass measurements, nuclear spectroscopy in the Penning trap interior as well as the laser spectroscopy on the extracted beams.

  10. Progress in atomic fountains at LNE-SYRTE.

    Science.gov (United States)

    Guéna, Jocelyne; Abgrall, Michel; Rovera, Daniele; Laurent, Philippe; Chupin, Baptiste; Lours, Michel; Santarelli, Giorgio; Rosenbusch, Peter; Tobar, Michael; Li, Ruoxin; Gibble, Kurt; Clairon, Andre; Bize, Sebastien

    2012-03-01

    We give an overview of the work done with the Laboratoire National de Métrologie et d'Essais-Systèmes de Référence Temps-Espace (LNE-SYRTE) fountain ensemble during the last five years. After a description of the clock ensemble, comprising three fountains, FO1, FO2, and FOM, and the newest developments, we review recent studies of several systematic frequency shifts. This includes the distributed cavity phase shift, which we evaluate for the FO1 and FOM fountains, applying the techniques of our recent work on FO2. We also report calculations of the microwave lensing frequency shift for the three fountains, review the status of the blackbody radiation shift, and summarize recent experimental work to control microwave leakage and spurious phase perturbations. We give current accuracy budgets. We also describe several applications in time and frequency metrology: fountain comparisons, calibrations of the international atomic time, secondary representation of the SI second based on the (87)Rb hyperfine frequency, absolute measurements of optical frequencies, tests of the T2L2 satellite laser link, and review fundamental physics applications of the LNE-SYRTE fountain ensemble. Finally, we give a summary of the tests of the PHARAO cold atom space clock performed using the FOM transportable fountain.

  11. My New Pen Pal

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This is my new pen pal. Her name is Annie. She is 14 years old. Her birthday is in August. She is from China. What does she look like? She is of medium height and thin. Site has beautiful long black hair. She can speak Chinese and a little English.

  12. 笔%Pen

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Small as it is,the pen has changed the course of history,shaped the destiny of nations,facilitated the commerce of peoples,imprisoned the elusive thoughts of man,recorded events,carried news,and done more work for mankind than all other tools or weapons.

  13. Efficient and Universal Corruption Resilient Fountain Codes

    CERN Document Server

    Cohen, Asaf; Tzachar, Nir

    2011-01-01

    In this paper, we present a new family of fountain codes which overcome adversarial errors. That is, we consider the possibility that some portion of the arriving packets of a rateless erasure code are corrupted in an undetectable fashion. In practice, the corrupted packets may be attributed to a portion of the communication paths which are controlled by an adversary or to a portion of the sources that are malicious. The presented codes resemble and extend LT and Raptor codes. Yet, their benefits over existing coding schemes are manifold. First, to overcome the corrupted packets, our codes use information theoretic techniques, rather than cryptographic primitives. Thus, no secret channel between the senders and the receivers is required. Second, the encoders in the suggested scheme are oblivious to the strength of the adversary, yet perform as if its strength was known in advance. Third, the sparse structure of the codes facilitates efficient decoding. Finally, the codes easily fit a decentralized scenario wi...

  14. Microfabrication materials for biomedical microdevices

    Science.gov (United States)

    Hansford, Derek James

    Major hurdles to the implementation of microfabricated devices for therapeutic applications include materials processing and biocompatibility issues. This dissertation reports research on improving the materials selection and fabrication for biomedical microdevices, using a microfabricated immunoisolation biocapsule as an example. Two material classes in the microfabrication protocol were examined based on the requirements determined for biomedical microdevices: the adhesive layer for bonding devices to encapsulate delicate biological substances and the thin film structural materials for surface structures, such as the biocapsule membrane. The major requirements for the adhesive layer material included non-cytotoxicity during bonding, adhesive strength, and durability under physiological conditions. Low glassy-phase transition temperature (Tg) methacrylates were found to be suitable candidates for adhesives of biomedical microdevices. A comparison study of poly propy1methacrylate (PPMA), poly (butyl, ethyl) methacrylate (PBEMA), and the higher Tg PMMA showed that all of the methacrylates had similar biocompatibility, adhesive strength, and durability. The adhesive strengths were found to be suitable for the adhesion of biomedical microdevices, as shown by measurement using a pressurized plate test and the current use of PMMA as bone cement. None of the methacrylates showed evidence of cytotoxicity, as measured by both optical and cytometric cell culture cytotoxicity tests. A protocol for the selective placement of smooth, thin films of PPMA using a Gel-PakTM transfer substrate was developed and demonstrated. The major requirements determined for the thin film structural materials were based on processing, mechanical, and biological parameters. Several candidates were identified as for structural materials based on these requirements: polycrystalline silicon. silicon nitride, fluoropolymers, PMMA, and silicone. A new fabrication protocol was developed to allow the

  15. CW fountain of laser-cooled Yb atoms

    CERN Document Server

    Rathod, K D; Natarajan, Vasant

    2013-01-01

    We demonstrate launching of laser-cooled Yb atoms in a continuous atomic fountain. The continuous fountain has significant advantages over the more common pulsed fountain, which was also demonstrated by us recently. The fountain is formed in the following steps---(i) Atoms from a thermal beam are first Zeeman slowed to a small final velocity, (ii) the slowed atoms are captured in a two-dimensional magneto-optic trap (2D-MOT), and (iii) atoms are launched {\\em continuously} in the vertical direction using two sets of moving-molasses beams, inclined at $\\pm 15^\\circ$ to the vertical. The cooling transition used is the strongly-allowed ${^1S}_0 \\rightarrow {^1P}_1$ transition at 399 nm. We capture about $7 \\times 10^6$ atoms in the 2D-MOT, and then launch them with a vertical velocity of 13 m/s at a longitudinal temperature of 125(6) mK.

  16. Final Critical Habitat for the Fountain darter (Etheostoma fonticola)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — To provide the user with a general idea of areas where final critical habitat for Fountain darter (Etheostoma fonticola) occur based on the description provided in...

  17. Microfabricated fuel heating value monitoring device

    Science.gov (United States)

    Robinson, Alex L.; Manginell, Ronald P.; Moorman, Matthew W.

    2010-05-04

    A microfabricated fuel heating value monitoring device comprises a microfabricated gas chromatography column in combination with a catalytic microcalorimeter. The microcalorimeter can comprise a reference thermal conductivity sensor to provide diagnostics and surety. Using microfabrication techniques, the device can be manufactured in production quantities at a low per-unit cost. The microfabricated fuel heating value monitoring device enables continuous calorimetric determination of the heating value of natural gas with a 1 minute analysis time and 1.5 minute cycle time using air as a carrier gas. This device has applications in remote natural gas mining stations, pipeline switching and metering stations, turbine generators, and other industrial user sites. For gas pipelines, the device can improve gas quality during transfer and blending, and provide accurate financial accounting. For industrial end users, the device can provide continuous feedback of physical gas properties to improve combustion efficiency during use.

  18. Colloidal pen lithography.

    Science.gov (United States)

    Xue, Mianqi; Cai, Xiaojing; Chen, Ghenfu

    2015-02-04

    Colloidal pen lithography, a low-cost, high-throughput scanning probe contact printing method, has been developed, which is based on self-assembled colloidal arrays embedded in a soft elastomeric stamp. Patterned protein arrays are demonstrated using this method, with a feature size ranging from 100 nm to several micrometers. A brief study into the specificity reorganization of protein gives evidence for the feasibility of this method for writing protein chips. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Microfabricated electroactive carbon nanotube actuators

    Science.gov (United States)

    Ahluwalia, Arti; Baughman, Ray H.; De Rossi, Danilo; Mazzoldi, Alberto; Tesconi, Mario; Tognetti, Alessandro; Vozzi, Giovanni

    2001-07-01

    A variety of microfabrication techniques have been developed at the University of Pisa. They are based either on pressure or piston actuated microsyringes or modified ink-jet printers. This work present the results of a study aimed at fabricating carbon nanotube (NT) actuators using micro-syringes. In order to prevent the nanotubes from aggregating into clumps, they were enclosed in a partially cross-linked polyvinylalcohol - polyallylamine matrix. After sonication the solution remained homogenously dispersed for about 40 minutes, which was sufficient time for deposition. Small strips of NT, about 5 mm across and 15 mm long were deposited. Following deposition, the films were baked at 80 degree(s)C and their thickness, impedance and mechanical resistance measured. The results indicate that 50 minutes of baking time is sufficient to give a constant resistivity of 1.12 x 10-2 (Omega) m per layer similar to a typical semiconductor, and each layer has a thickness of about 6 micrometers .

  20. Microfabrication of fiber optic scanners

    Science.gov (United States)

    Fauver, Mark; Crossman-Bosworth, Janet L.; Seibel, Eric J.

    2002-06-01

    A cantilevered optical fiber is micromachined to function as a miniature resonant opto-mechanical scanner. By driving the base of the cantilevered fiber at a resonance frequency using a piezoelectric actuator, the free end of the cantilever beam becomes a scanned light source. The fiber scanners are designed to achieve wide field-of-view (FOV) and high scan frequency. We employ a non-linearly tapered profile fiber to achieve scan amplitudes of 1 mm at scan frequencies above 20 KHz. Scan angles of over 120 degree(s) (full angle) have been achieved. Higher order modes are also employed for scanning applications that require compactness while maintaining large angular FOV. Etching techniques are used to create the non-linearly tapered sections in single mode optical fiber. Additionally, micro-lenses are fabricated on the tips of the etched fibers, with lens diameters as small as 15 microns. Such lenses are capable of reducing the divergence angle of the emitted light to 5 degree(s) (full angle), with greater reduction expected by employing novel lens shaping techniques. Microfabricated optical fiber scanners have display applications ranging from micro-optical displays to larger panoramic displays. Applications for micro-image acquisition include small barcode readers to medical endoscopes.

  1. Progress in Atomic Fountains at LNE-SYRTE

    CERN Document Server

    Guéna, Jocelyne; Rovera, Daniele; Laurent, Philippe; Chupin, Baptiste; Lours, Michel; Santarelli, Giorgio; Rosenbusch, Peter; Tobar, Michael E; Li, Ruoxin; Gibble, Kurt; Clairon, André; Bize, Sébastien; 10.1109/TUFFC.2012.2208

    2012-01-01

    We give an overview of the work done with the Laboratoire National de M\\'etrologie et d'Essais-Syst\\`emes de R\\'ef\\'erence Temps-Espace (LNE-SYRTE) fountain ensemble during the last five years. After a description of the clock ensemble, comprising three fountains, FO1, FO2, and FOM, and the newest developments, we review recent studies of several systematic frequency shifts. This includes the distributed cavity phase shift, which we evaluate for the FO1 and FOM fountains, applying the techniques of our recent work on FO2. We also report calculations of the microwave lensing frequency shift for the three fountains, review the status of the blackbody radiation shift, and summarize recent experimental work to control microwave leakage and spurious phase perturbations. We give current accuracy budgets. We also describe several applications in time and frequency metrology: fountain comparisons, calibrations of the international atomic time, secondary representation of the SI second based on the 87Rb hyperfine freq...

  2. UKRAINIAN FOUNTAINS OPEN HEARTH INFECTIOUS DISEASES: CAUSES, SITUATION ANALYSIS, SOLUTION

    Directory of Open Access Journals (Sweden)

    Moskovkin V.M.

    2011-06-01

    Full Text Available The paper examined the causal links that explain the pattern of contamination of water systems of water recycling fountains by pathogens and proved the rreversibility of the formation of the path of infection of domestic population of by airborne droplets, formed by microbial fogs. Studies of microbiolodical contamination of water allowed to obtain informative features for preliminary analysis of epidemiological danger of fountains and provided an opportunity to identify the dominant factor – high levels of Mycobacterium tuberculosis in aerosol droplets. On the basis of the collected databases were formulated technical conditions to ensure the security of the collected databases were formulated technical conditions to ensure the security of citizens from all possible negative impacts of fountains, realized in the form of water disinfection technology working with silver and copper, which consistent with international sanitary rules, regulations Ministry of Health Care of Ukraine and environmental legislation.

  3. Galactic dynamo and helicity losses through fountain flow

    CERN Document Server

    Shukurov, A; Subramanian, K; Brandenburg, A; Shukurov, Anvar; Sokoloff, Dmitry; Subramanian, Kandaswamy; Brandenburg, Axel

    2006-01-01

    Nonlinear behaviour of galactic dynamos is studied, allowing for magnetic helicity removal by the galactic fountain flow. A suitable advection speed is estimated, and a one-dimensional mean-field dynamo model with dynamic alpha-effect is explored. It is shown that the galactic fountain flow is efficient in removing magnetic helicity from galactic discs. This alleviates the constraint on the galactic mean-field dynamo resulting from magnetic helicity conservation and thereby allows the mean magnetic field to saturate at a strength comparable to equipartition with the turbulent kinetic energy.

  4. Improvement of penning ion sources

    CERN Document Server

    Bizyukov, A A; Kashaba, A Y; Sereda, K N

    2000-01-01

    It is shown that the loss of a longitudinal symmetry of magnetic field distribution in respect to the centre of the Penning discharge system causes change of electrostatic potential distribution in the discharge gap leads to appearance of asymmetry of current magnitude to the cathodes of the Penning cell,change of magnitude of current density and energy distribution of the ion beam extracted in a longitudinal direction.The use of an inhomogeneous magnetic field which is longitudinally asymmetrical concerning electrodes of the system allows to increase current efficiency of Penning ion sources from 0,2 to 0,55.

  5. Realisation of a Frequency Standard Using an Atomic Fountain

    CERN Document Server

    Michaud, A; Zetie, K P; Cooper, C J; Hillenbrand, G; Lorent, V; Steane, A; Foot, C J

    2005-01-01

    We report the realisation and preliminary study of a frequency standard using a fountain of laser cooled caesium atoms. Our apparatus uses a magneto-optical trap as a source of cold atoms and optical pumping to prepare the atoms in the correct state before they enter the microwave cavity.

  6. The Ammonia Smoke Fountain: An Interesting Thermodynamic Adventure.

    Science.gov (United States)

    Alexander, M. Dale

    1999-01-01

    Describes a new demonstration that uses an apparatus like the ammonia-fountain apparatus but with modifications designed to produce ammonium-chloride smoke. This demonstration is easy to perform, interesting to observe, and allows demonstration of the solubility of ammonia in water, the basic nature of ammonia, the acidic nature of hydrogen…

  7. Performance and Applications of an Ensemble of Atomic Fountains

    Science.gov (United States)

    2012-01-01

    clock based time scale,” Metrologia 49, pp. 180-188 (2012). [2] T. Parker, S. Jefferts, T. Heavner, and E. Donley, “Operation of the NIST-F1 caesium...fountain primary standard with a maser ensemble, including the impact of frequency transfer noise,” Metrologia 42, pp. 423-430 (2005). [3] J. Guéna, et

  8. The Fountain of Living Water and the Deceitful Brook

    DEFF Research Database (Denmark)

    Holt, Else Kragelund

    2005-01-01

    The metaphor "God is Water" is distinctive for the Book of Jeremiah in different variants. The core metaphor is found in Jer 2:13, it is elaborated in other instances as: "God is a fountain", or "God is not a wasteland" (chapter 2), and it is gainsaid in 15:18 which reads: "You are to me like a d...

  9. Effects of PCB thickness on adjustable fountain wave soldering

    Indian Academy of Sciences (India)

    M S Abdul Aziz; M Z Abdullah; C Y Khor; A Jalar; M A Bakar; W Y W Yusoff; F Che Ani; Nobe Yan; M Zhou; C Cheok

    2015-10-01

    This study investigates the effects of printed circuit board (PCB) thickness on adjustable fountain and conventional wave soldering. The pin-through-hole (PTH) vertical fill is examined with three PCBs of different thicknesses (i.e., 1.6, 3.1, and 6.0 mm) soldered through adjustable fountain and conventional wave soldering at conveyor angles of 0° and 6°. The vertical fill of each PCB is the focus. The PTH solder profile is inspected with a non-destructive X-ray computed tomography scanning machine. The percentages of the PTH vertical fill of both soldering processes are also estimated and compared. The aspect ratio of the PCB is also investigated. Experimental results reveal that adjustable fountain wave soldering yields better vertical fill than conventional wave soldering. The vertical fill level of adjustable fountain wave soldering is 100%, 90%, and 50% for the 1.6, 3.1, and 6.0 mm PCB thickness, respectively. FLUENT simulation is conducted for the vertical fill of the solder profile. Simulation and experimental results show that the PTH solder profiles of the two soldering processes are almost identical. The effect of PCB thickness on PTH voiding is also discussed.

  10. Fold optics path: an improvement for an atomic fountain

    Institute of Scientific and Technical Information of China (English)

    Wei Rong; Zhou Zi-Chao; Shi Chun-Yan; Zhao Jian-Bo; Li Tang; Wang Yu-zhu

    2011-01-01

    A fold optical path is utilized to capture and launch atoms in the atomic fountain.This improved technique reduces the laser power needed by 60 percent,facilitates suppression of the laser power fluctuations,and leads to a more simple and stable system.

  11. Processing of Nanostructured Devices Using Microfabrication Techniques

    Science.gov (United States)

    Hunter, Gary W (Inventor); Xu, Jennifer C (Inventor); Evans, Laura J (Inventor); Kulis, Michael H (Inventor); Berger, Gordon M (Inventor); Vander Wal, Randall L (Inventor)

    2014-01-01

    Systems and methods that incorporate nanostructures into microdevices are discussed herein. These systems and methods can allow for standard microfabrication techniques to be extended to the field of nanotechnology. Sensors incorporating nanostructures can be fabricated as described herein, and can be used to reliably detect a range of gases with high response.

  12. Optical pumping in a microfabricated Rb vapor cell using a microfabricated Rb discharge light source

    Energy Technology Data Exchange (ETDEWEB)

    Venkatraman, V.; Kang, S.; Affolderbach, C.; Mileti, G., E-mail: gaetano.mileti@unine.ch [Laboratoire Temps-Fréquence, University of Neuchâtel, Neuchâtel 2000 (Switzerland); Shea, H. [Microsystems for Space Technologies Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), Neuchâtel 2002 (Switzerland)

    2014-02-03

    Miniature (microfabricated alkali vapor resonance cell using (1) a microfabricated Rb discharge lamp light source, as well as (2) a conventional glass-blown Rb discharge lamp. The microfabricated Rb lamp cell is a dielectric barrier discharge (DBD) light source, having the same inner cell volume of around 40 mm{sup 3} as that of the resonance cell, both filled with suitable buffer gases. A miniature (∼2 cm{sup 3} volume) test setup based on the M{sub z} magnetometer interrogation technique was used for observation of optical-radiofrequency double-resonance signals, proving the suitability of the microfabricated discharge lamp to introduce efficient optical pumping. The pumping ability of this light source was found to be comparable to or even better than that of a conventional glass-blown lamp. The reported results indicate that the micro-fabricated DBD discharge lamp has a high potential for the development of a new class of miniature atomic clocks, magnetometers, and quantum sensors.

  13. Microfabricated bulk wave acoustic bandgap device

    Science.gov (United States)

    Olsson, Roy H.; El-Kady, Ihab F.; McCormick, Frederick; Fleming, James G.; Fleming, Carol

    2010-06-08

    A microfabricated bulk wave acoustic bandgap device comprises a periodic two-dimensional array of scatterers embedded within the matrix material membrane, wherein the scatterer material has a density and/or elastic constant that is different than the matrix material and wherein the periodicity of the array causes destructive interference of the acoustic wave within an acoustic bandgap. The membrane can be suspended above a substrate by an air or vacuum gap to provide acoustic isolation from the substrate. The device can be fabricated using microelectromechanical systems (MEMS) technologies. Such microfabricated bulk wave phononic bandgap devices are useful for acoustic isolation in the ultrasonic, VHF, or UHF regime (i.e., frequencies of order 1 MHz to 10 GHz and higher, and lattice constants of order 100 .mu.m or less).

  14. Using Moeller PLC in automation of an artesian fountains

    Science.gov (United States)

    Barz, C.; Latinovic, T.; Deaconu, S.; Preradović, D.; Pop, P. P.; Pop-Vadean, A.

    2017-01-01

    The paper presents the use of a Moeller PLC in the automation of an artesian fountains from Baia Mare. The application is developed in Ladder Diagram and contains two modes of operation. The first mode is the Automatic Mode in which are defines certain operating times of the artesian fountains pumps. These set times make recurrence of the operation. The second mode is the Manual Mode in which each pump is operated independently. Manual mode is only active for service personal, according to the user accounts and authorization rights of its. All orders are made with a touch screen Weintek in menus that are created for application. Using the Service Menu can visualize defects occurred during the regime of operation, which is recorded.

  15. Atomic fountains and optical clocks at SYRTE: status and perspectives

    CERN Document Server

    Abgrall, M; De Sarlo, L; Guéna, J; Laurent, Ph; Coq, Y Le; Targat, R Le; Lodewyck, J; Lours, M; Rosenbusch, P; Rovera, D; Bize, S

    2015-01-01

    In this article, we report on the work done with the LNE-SYRTE atomic clock ensemble during the last 10 years. We cover progress made in atomic fountains and in their application to timekeeping. We also cover the development of optical lattice clocks based on strontium and on mercury. We report on tests of fundamental physical laws made with these highly accurate atomic clocks. We also report on work relevant to a future possible redefinition of the SI second.

  16. Ultrasonic atomization of liquids in drop-chain acoustic fountains

    OpenAIRE

    Simon, Julianna C.; Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Crum, Lawrence A.; Bailey, Michael R.

    2015-01-01

    When focused ultrasound waves of moderate intensity in liquid encounter an air interface, a chain of drops emerges from the liquid surface to form what is known as a drop-chain fountain. Atomization, or the emission of micro-droplets, occurs when the acoustic intensity exceeds a liquid-dependent threshold. While the cavitation-wave hypothesis, which states that atomization arises from a combination of capillary-wave instabilities and cavitation bubble oscillations, is currently the most accep...

  17. Carbon dioxide heat pump for dual-temperature drinking fountain

    Institute of Scientific and Technical Information of China (English)

    杨大章; 吕静; 何哲彬; 黄秀芝

    2009-01-01

    Carbon dioxide trans-critical heat pump system for heating and cooling water was designed,and its thermodynamic steady-state concentration model was established. Based on the steady-state model,parameters of the carbon dioxide trans-critical heat pump were calculated by computer programming. According to these parameters,the effects and application prospect of the heat pump system were analyzed for dual-temperature drinking fountains.

  18. Adventures of a Pen Pal

    Institute of Scientific and Technical Information of China (English)

    Myrtle"Cookie"Potter; 谢琼

    2000-01-01

    By the time I was in junior high schoolI had 15 pen pals with whom I correspond-ed faithfully. I found that being a pen palwas a nonthreatening way of makingfriends. All my correspondents lived in SanFrancisco, while I was about 15 miles south inBurlingame. They were all too young to drive,so the chances we d meet were slim. Since Iwas extremely bashful, this suited me fine. I found my correspondents in the 1928 San

  19. Mylan to Offer Generic EpiPen

    Science.gov (United States)

    ... news/fullstory_160669.html Mylan to Offer Generic EpiPen Manufacturer responds to mounting criticism about price hikes ... cheaper generic version of the emergency allergy treatment EpiPen will be made available within the next few ...

  20. 9 CFR 89.5 - Feeding pens.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Feeding pens. 89.5 Section 89.5... TWENTY-EIGHT HOUR LAW § 89.5 Feeding pens. (a) Stock pens and other enclosures for feeding, watering, and... same time, (2) properly designed facilities for feeding and watering the livestock, (3) reasonably...

  1. Planar Ion Trap Geometry for Microfabrication

    CERN Document Server

    Madsen, M J; Stick, D; Rabchuk, J A; Monroe, C

    2004-01-01

    We describe a novel high aspect ratio radiofrequency linear ion trap geometry that is amenable to modern microfabrication techniques. The ion trap electrode structure consists of a pair of stacked conducting cantilevers resulting in confining fields that take the form of fringe fields from parallel plate capacitors. The confining potentials are modeled both analytically and numerically. This ion trap geometry may form the basis for large scale quantum computers or parallel quadrupole mass spectrometers. PACS: 39.25.+k, 03.67.Lx, 07.75.+h, 07.10+Cm

  2. Trends in Microfabrication Capabilities & Device Architectures.

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Todd [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Adam [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lentine, Tony [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mudrick, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Okandan, Murat [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rodrigues, Arun [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-06-01

    The last two decades have seen an explosion in worldwide R&D, enabling fundamentally new capabilities while at the same time changing the international technology landscape. The advent of technologies for continued miniaturization and electronics feature size reduction, and for architectural innovations, will have many technical, economic, and national security implications. It is important to anticipate possible microelectronics development directions and their implications on US national interests. This report forecasts and assesses trends and directions for several potentially disruptive microfabrication capabilities and device architectures that may emerge in the next 5-10 years.

  3. Trends in Microfabrication Capabilities & Device Architectures.

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Todd [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Adam [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lentine, Anthony L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mudrick, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Okandan, Murat [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rodrigues, Arun F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-06-01

    The last two decades have seen an explosion in worldwide R&D, enabling fundamentally new capabilities while at the same time changing the international technology landscape. The advent of technologies for continued miniaturization and electronics feature size reduction, and for architectural innovations, will have many technical, economic, and national security implications. It is important to anticipate possible microelectronics development directions and their implications on US national interests. This report forecasts and assesses trends and directions for several potentially disruptive microfabrication capabilities and device architectures that may emerge in the next 5-10 years.

  4. 3D laser microfabrication principles and applications

    CERN Document Server

    Misawa, Hiroaki

    2006-01-01

    A thorough introduction to 3D laser microfabrication technology, leading readers from the fundamentals and theory to its various potent applications, such as the generation of tiny objects or three-dimensional structures within the bulk of transparent materials. The book also presents new theoretical material on dielectric breakdown, allowing a better understanding of the differences between optical damage on surfaces and inside the bulk, as well as a look into the future.Chemists, physicists, materials scientists and engineers will find this a valuable source of interdisciplinary know

  5. Microfabrication of hybrid fluid membrane for microengines

    Science.gov (United States)

    Chutani, R.; Formosa, F.; de Labachelerie, M.; Badel, A.; Lanzetta, F.

    2015-12-01

    This paper describes the microfabrication and dynamic characterization of thick membranes providing a technological solution for microengines. The studied membranes are called hybrid fluid-membrane (HFM) and consist of two thin membranes that encapsulate an incompressible fluid. This work details the microelectromechanical system (MEMS) scalable fabrication and characterization of HFMs. The membranes are composite structures based on Silicon spiral springs embedded in a polymer (RTV silicone). The anodic bonding of multiple stacks of Si/glass structures, the fluid filling and the sealing have been demonstrated. Various HFMs were successfully fabricated and their dynamic characterization demonstrates the agreement between experimental and theoretical results.

  6. Microfabricated linear Paul-Straubel ion trap

    Science.gov (United States)

    Mangan, Michael A.; Blain, Matthew G.; Tigges, Chris P.; Linker, Kevin L.

    2011-04-19

    An array of microfabricated linear Paul-Straubel ion traps can be used for mass spectrometric applications. Each ion trap comprises two parallel inner RF electrodes and two parallel outer DC control electrodes symmetric about a central trap axis and suspended over an opening in a substrate. Neighboring ion traps in the array can share a common outer DC control electrode. The ions confined transversely by an RF quadrupole electric field potential well on the ion trap axis. The array can trap a wide array of ions.

  7. A Microfabricated Inductively Coupled Plasma Excitation Source

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-Qing; PU Yong-Ni; SUN Rong-Xia; TANG Yu-Jun; CHEN Wen-Jun; LOU Jian-Zhong; MA Wen

    2008-01-01

    A novel miniaturization of inductively coupled plasma(ICP)source based on printed circuit produced using micro-fabrication techniques is presented.The basic parameters of the novel ICP,including its radio frequency,power loss,size,and argon consumption are less than 1% of that for the case of atmospheric pressure ICP source.For example,at 100 Pa of argon gas pressure,the present ICP source can be ignited by using the rf power less than 3.5 W.Potential applications of the ICP is discussed.

  8. Fountain Set Limited Launched New Products of 2011 Autumn-Winter Collections:Eco-friendliness and Multi-category

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Fountain Set Limited announced that its branch brand"Fountain Set" was producing 2011 autumn-winter collections on the 2010 Intertextile Shanghai Apparel Fabrics Trade Fair,displaying new products embraced

  9. VLA observations of the "water fountain" IRAS 16552-3050

    OpenAIRE

    Suárez, Olga; Gómez, J. F.; Miranda, L. F.

    2008-01-01

    We present Very Large Array (VLA) observations of the water maser emission towards IRAS 16552-3050. The maser emission shows a velocity spread of ~170 km/s, and a bipolar distribution with a separation between the red and blueshifted groups of ~0.08". These observations and the likely post-AGB nature of the source indicate that IRAS 16552-3050 can be considered as a member of the "water fountain" class of sources (evolved stars showing H2O maser emission with a velocity spread $\\ga$ 100 km/s,...

  10. Fountain-driven gas accretion by the Milky Way

    Directory of Open Access Journals (Sweden)

    Ciotti L.

    2012-02-01

    Full Text Available Accretion of fresh gas at a rate of ∼ 1M☉yr−1 is necessary in star-forming disc galaxies, such as the Milky Way, in order to sustain their star-formation rates. In this work we present the results of a new hydrodynamic simulation supporting the scenario in which the gas required for star formation is drawn from the hot corona that surrounds the star-forming disc. In particular, the cooling of this hot gas and its accretion on to the disc are caused by the passage of cold galactic fountain clouds through the corona.

  11. Conservation of the stone in Cibeles Fountain, Madrid , Spain

    Directory of Open Access Journals (Sweden)

    López de Azcona, M. C.

    2002-03-01

    Full Text Available The water in Cibeles Fountain flows in a closed circuit and is replaced every 6 months. After this period of time, an increase in bicarbonate, sulfate, calcium and magnesium contents is registered in the water, as well as a slight increase in its acidity. This acidity, favored by atmospheric pollution, is the main cause for the process of dissolution that marble used in the ornamental sections of the fountain undergoes. Calcite-based marble, from the Carrara quarries in Italy, of the cherubs suffers the most acute dissolution processes, while dolomite-based marble, used for the main sculpture body is less affected by these processes. Dissolved materials fall on certain sections of the sculpture and of the fountain forming dirt crusts and inlaid soiling. In order to prevent decay of the fountain building materials, periodical control of water composition is necessary, with a view to stabilizing water pH level at around 7.8. It is likewise necessary to add chemicals that prevent bacteria and algae proliferation, thus improving water quality.

    El agua de la Fuente de Cibeles funciona en un circuito cerrado, con cambio cada seis meses del agua. Al final de un periodo el agua tiende a incrementar su contenido en bicarbonatos, sulfatos, calcio y magnesio, con una ligero aumento de su acidez, con respecto al agua original. Esta acidez, favorecida por la acción de la contaminación atmosférica, genera procesos de disolución en los mármoles con los que está esculpida la parte escultórica de la Fuente. Son los mármoles calcíticos, procedentes de las canteras de Carrara (Italia, de los amorcillos, los que tienen un mayor proceso de disolución, mientras que los mármoles dolomíticos, con los que está esculpido el conjunto escultórico principal, presentan menos procesos de disolución. Los elementos en disolución precipitan en zonas determinadas del conjunto escultórico y en elementos de la Fuente, dando la formación de costras e

  12. Microfabrication and nanotechnology in stent design.

    Science.gov (United States)

    Martinez, Adam W; Chaikof, Elliot L

    2011-01-01

    Intravascular stents were first introduced in the 1980s as an adjunct to primary angioplasty for management of early complications, including arterial dissection, or treatment of an inadequate technical outcome due to early elastic recoil of the atherosclerotic lesion. Despite the beneficial effects of stenting, persistent high rates of restenosis motivated the design of drug-eluting stents for delivery of agents to limit the proliferative and other inflammatory responses within the vascular wall that contribute to the development of a restenotic lesion. These strategies have yielded a significant reduction in the incidence of restenosis, but challenges remain, including incomplete repair of the endothelium at the site of vascular wall injury that may be associated with a late risk of thrombosis. A failure of vessel wall healing has been attributed primarily to the use of polymeric stent coatings, but the effects of the eluted drug and other material properties or design features of the stent cannot be excluded. Improvements in stent microfabrication, as well as the introduction of alternative materials may help to address those limitations that inhibit stent performance. This review describes the application of novel microfabrication processes and the evolution of new nanotechnologies that hold significant promise in eliminating existing shortcomings of current stent platforms.

  13. Microfabricated wire arrays for Z-pinch.

    Energy Technology Data Exchange (ETDEWEB)

    Spahn, Olga Blum; Rowen, Adam M.; Cich, Michael Joseph; Peake, Gregory Merwin; Arrington, Christian L.; Nash, Thomas J.; Klem, John Frederick; Romero, Dustin Heinz

    2008-10-01

    Microfabrication methods have been applied to the fabrication of wire arrays suitable for use in Z. Self-curling GaAs/AlGaAs supports were fabricated as an initial route to make small wire arrays (4mm diameter). A strain relief structure that could be integrated with the wire was designed to allow displacements of the anode/cathode connections in Z. Electroplated gold wire arrays with integrated anode/cathode bus connections were found to be sufficiently robust to allow direct handling. Platinum and copper plating processes were also investigated. A process to fabricate wire arrays on any substrate with wire thickness up to 35 microns was developed. Methods to handle and mount these arrays were developed. Fabrication of wire arrays of 20mm diameter was demonstrated, and the path to 40mm array fabrication is clear. With some final investment to show array mounting into Z hardware, the entire process to produce a microfabricated wire array will have been demonstrated.

  14. Hard Transparent Arrays for Polymer Pen Lithography.

    Science.gov (United States)

    Hedrick, James L; Brown, Keith A; Kluender, Edward J; Cabezas, Maria D; Chen, Peng-Cheng; Mirkin, Chad A

    2016-03-22

    Patterning nanoscale features across macroscopic areas is challenging due to the vast range of length scales that must be addressed. With polymer pen lithography, arrays of thousands of elastomeric pyramidal pens can be used to write features across centimeter-scales, but deformation of the soft pens limits resolution and minimum feature pitch, especially with polymeric inks. Here, we show that by coating polymer pen arrays with a ∼175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (∼40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. With these new arrays, patterns with as many as 5.9 billion features in a 14.5 cm(2) area were written using a four hundred thousand pyramid pen array. Furthermore, a new method is demonstrated for patterning macroscopic feature size gradients that vary in feature diameter by a factor of 4. Ultimately, this form of polymer pen lithography allows for patterning with the resolution of dip-pen nanolithography across centimeter scales using simple and inexpensive pen arrays. The high resolution and density afforded by this technique position it as a broad-based discovery tool for the field of nanocombinatorics.

  15. The Galactic fountain as an origin for the Smith Cloud

    Science.gov (United States)

    Marasco, A.; Fraternali, F.

    2017-01-01

    The recent discovery of an enriched metallicity for the Smith high-velocity H I Cloud (SC) lends support to a Galactic origin for this system. We use a dynamical model of the galactic fountain to reproduce the observed properties of the SC. In our model, fountain clouds are ejected from the region of the disc spiral arms and move through the halo interacting with a pre-existing hot corona. We find that a simple model where cold gas outflows vertically from the Perseus spiral arm reproduces the kinematics and the distance of the SC, but is in disagreement with the cloud's cometary morphology, if this is produced by ram-pressure stripping by the ambient gas. To explain the cloud morphology, we explore two scenarios: (i) the outflow is inclined with respect to the vertical direction and (ii) the cloud is entrained by a fast wind that escapes an underlying superbubble. Solutions in agreement with all observational constraints can be found for both cases, the former requires outflow angles >40° while the latter requires ≳1000 km s-1 winds. All scenarios predict that the SC is in the ascending phase of its trajectory and has large - but not implausible - energy requirements.

  16. The Galactic fountain as an origin for the Smith Cloud

    CERN Document Server

    Marasco, Antonino

    2016-01-01

    The recent discovery of an enriched metallicity for the Smith high-velocity HI cloud (SC) lends support to a Galactic origin for this system. We use a dynamical model of the galactic fountain to reproduce the observed properties of the SC. In our model, fountain clouds are ejected from the region of the disc spiral arms and move through the halo interacting with a pre-existing hot corona. We find that a simple model where cold gas outflows vertically from the Perseus spiral arm reproduces the kinematics and the distance of the SC, but is in disagreement with the cloud's cometary morphology, if this is produced by ram-pressure stripping by the ambient gas. To explain the cloud morphology we explore two scenarios: a) the outflow is inclined with respect to the vertical direction; b) the cloud is entrained by a fast wind that escapes an underlying superbubble. Solutions in agreement with all observational constraints can be found for both cases, the former requires outflow angles >40 deg while the latter require...

  17. Micro Penning Trap for Continuous Magnetic Field Monitoring in High Radiation Environments

    Science.gov (United States)

    Latorre, Javiera; Bollen, Georg; Gulyuz, Kerim; Ringle, Ryan; Bado, Philippe; Dugan, Mark; Lebit Team; Translume Collaboration

    2016-09-01

    As new facilities for rare isotope beams, like FRIB at MSU, are constructed, there is a need for new instrumentation to monitor magnetic fields in beam magnets that can withstand the higher radiation level. Currently NMR probes, the instruments used extensively to monitor magnetic fields, do not have a long lifespans in radiation-high environments. Therefore, a radiation-hard replacement is needed. We propose to use Penning trap mass spectrometry techniques to make high precision magnetic field measurements. Our Penning microtrap will be radiation resistant as all of the vital electronics will be at a safe distance from the radiation. The trap itself is made from materials not subject to radiation damage. Penning trap mass spectrometers can determine the magnetic field by measuring the cyclotron frequency of an ion with a known mass and charge. This principle is used on the Low Energy Beam Ion Trap (LEBIT) minitrap at NSCL which is the foundation for the microtrap. We have partnered with Translume, who specialize in glass micro-fabrication, to develop a microtrap in fused-silica glass. A microtrap is finished and ready for testing at NSCL with all of the electronic and hardware components setup. DOE Phase II SBIR Award No. DE-SC0011313, NSF Award Number 1062410 REU in Physics, NSF under Grant No. PHY-1102511.

  18. Microfabricated high-throughput electronic particle detector

    Science.gov (United States)

    Wood, D. K.; Requa, M. V.; Cleland, A. N.

    2007-10-01

    We describe the design, fabrication, and use of a radio frequency reflectometer integrated with a microfluidic system, applied to the very high-throughput measurement of micron-scale particles, passing in a microfluidic channel through the sensor region. The device operates as a microfabricated Coulter counter [U.S. Patent No. 2656508 (1953)], similar to a design we have described previously, but here with significantly improved electrode geometry as well as including electronic tuning of the reflectometer; the two improvements yielding an improvement by more than a factor of 10 in the signal to noise and in the diametric discrimination of single particles. We demonstrate the high-throughput discrimination of polystyrene beads with diameters in the 4-10μm range, achieving diametric resolutions comparable to the intrinsic spread of diameters in the bead distribution, at rates in excess of 15×106beads/h.

  19. Non-planar microfabricated gas chromatography column

    Science.gov (United States)

    Lewis, Patrick R.; Wheeler, David R.

    2007-09-25

    A non-planar microfabricated gas chromatography column comprises a planar substrate having a plurality of through holes, a top lid and a bottom lid bonded to opposite surfaces of the planar substrate, and inlet and outlet ports for injection of a sample gas and elution of separated analytes. A plurality of such planar substrates can be aligned and stacked to provide a longer column length having a small footprint. Furthermore, two or more separate channels can enable multi-channel or multi-dimensional gas chromatography. The through holes preferably have a circular cross section and can be coated with a stationary phase material or packed with a porous packing material. Importantly, uniform stationary phase coatings can be obtained and band broadening can be minimized with the circular channels. A heating or cooling element can be disposed on at least one of the lids to enable temperature programming of the column.

  20. Micromanipulation and microfabrication for optical microrobotics

    DEFF Research Database (Denmark)

    Palima, Darwin; Bañas, Andrew Rafael; Vizsnyiczai, Gaszton

    2012-01-01

    to microfabricated, free-standing waveguides can be used not only to redirect light for targeted delivery of optical energy but can also for targeted delivery of optical force, which can serve to further extend the manipulation arms in optical robotics. Moreover, light deflection with waveguide also creates a recoil......Robotics can use optics feedback in vision-based control of intelligent robotic guidance systems. With light’s miniscule momentum, shrinking robots down to the microscale regime creates opportunities for exploiting optical forces and torques in microrobotic actuation and control. Indeed...... and fabricated them by two-photon polymerization. These microstructures were then handled using our biophotonics workstation (BWS) for proof-of-principle demonstrations of optical actuation, akin to 6DOF actuation of robotic micromanipulators. Furthermore, we also show an example of dynamic behavior...

  1. Microfabricated biomaterials for engineering 3D tissues.

    Science.gov (United States)

    Zorlutuna, Pinar; Annabi, Nasim; Camci-Unal, Gulden; Nikkhah, Mehdi; Cha, Jae Min; Nichol, Jason W; Manbachi, Amir; Bae, Hojae; Chen, Shaochen; Khademhosseini, Ali

    2012-04-10

    Mimicking natural tissue structure is crucial for engineered tissues with intended applications ranging from regenerative medicine to biorobotics. Native tissues are highly organized at the microscale, thus making these natural characteristics an integral part of creating effective biomimetic tissue structures. There exists a growing appreciation that the incorporation of similar highly organized microscale structures in tissue engineering may yield a remedy for problems ranging from vascularization to cell function control/determination. In this review, we highlight the recent progress in the field of microscale tissue engineering and discuss the use of various biomaterials for generating engineered tissue structures with microscale features. In particular, we will discuss the use of microscale approaches to engineer the architecture of scaffolds, generate artificial vasculature, and control cellular orientation and differentiation. In addition, the emergence of microfabricated tissue units and the modular assembly to emulate hierarchical tissues will be discussed. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. A microfabricated optically-pumped magnetic gradiometer

    Science.gov (United States)

    Sheng, D.; Perry, A. R.; Krzyzewski, S. P.; Geller, S.; Kitching, J.; Knappe, S.

    2017-01-01

    We report on the development of a microfabricated atomic magnetic gradiometer based on optical spectroscopy of alkali atoms in the vapor phase. The gradiometer, which operates in the spin-exchange relaxation free regime, has a length of 60 mm and cross sectional diameter of 12 mm, and consists of two chip-scale atomic magnetometers which are interrogated by a common laser light. The sensor can measure differences in magnetic fields, over a 20 mm baseline, of 10 fT/ Hz1 /2 at frequencies above 20 Hz. The maximum rejection of magnetic field noise is 1000 at 10 Hz. By use of a set of compensation coils wrapped around the sensor, we also measure the sensor sensitivity at several external bias field strengths up to 150 mG. This device is useful for applications that require both sensitive gradient field information and high common-mode noise cancellation.

  3. Microfabricated, 94 GHz, 25 W, Helical Traveling Wave Tube Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Teraphysics Corporation proposes to design and develop a microfabricated, 94 GHz, 25 W traveling wave tube (TWT) with 53% efficiency for NASA applications. In Phase...

  4. Nosocomial outbreak of Pseudomonas aeruginosa associated with a drinking water fountain.

    Science.gov (United States)

    Costa, D; Bousseau, A; Thevenot, S; Dufour, X; Laland, C; Burucoa, C; Castel, O

    2015-11-01

    Over a four-month period, ten patients were suspected of having acquired nosocomial infection to P. aeruginosa in the ear, nose, and throat department. Environmental and clinical isolates were compared. Only water from a drinking water fountain was contaminated by P. aeruginosa. This isolate and those of three patients had indistinguishable random amplified polymorphic DNA profiles. These patients had serious oncology diseases. The drinking water fountain was used for their alimentation by percutaneous endoscopic gastrostomy and was the origin of the outbreak. Another type of drinking fountain with a terminal ultraviolet treatment was installed, following which no new infections linked to drinking water were identified.

  5. Complex fragmentation and silicification structures in fault zones: quartz mineralization and repeated fragmentation along the Fountain Range Fault (Mt. Isa Inlier, Australia)

    Science.gov (United States)

    Seybold, Lina; Blenkinsop, Tom; Heuss, Soraya; Ord, Alison; Kruhl, Jörn H.

    2015-04-01

    In large-scale fault zones fracture networks are commonly generated by high volumes of pressurized fluids, followed by quartz precipitation. In this way large amounts of quartz are formed as microcrystalline masses and as complex vein systems, with partly highly different textures, as a result of different formation processes. Based on field and microstructural data and the quantification of vein patterns, the spatial and temporal connection between fragmentation, quartz crystallization and fluid and material flow along the Fountain Range Fault at Fountain Springs was investigated. Dextral strike-slip led to up to 25 km horizontal displacement along the fault. Due to various fragmentation and quartz formation processes, a ca. 100 m high, 80 - 100 m wide and km-long quartz ridge with numerous vein systems and variable microfabrics was formed. Locally, lenses of highly altered metamorphic wall-rocks occur in the quartz zone. Where exposed, the contact to wall rocks is sharp. Millimetre- to decimetre-thick quartz veins penetrate the wall-rocks only within metre distance from the contact. Several clearly distinguishable fine-grained reddish, brownish to dark and pigment-rich quartz masses form up to 50 m wide and up to several 100 m long steep lenses that build the major part of the silicified fault zone. A chronology can be established. Some of these lenses are oriented slightly oblique to the general trend of the quartz zone, in agreement with the supposed dextral strike slip along the fault. Numerous generations of typically µm-cm thick quartz veins transect the microcrystalline quartz masses and, locally, form anisotropic networks. In the quartz masses, angular fragments often composed of quartz with, again, internal fragmentation structures, indicate earlier fracturing and silicification events. Within the veins, quartz forms geodes, locally filled with fine-grained reddish quartz and palisade structures with feathery textures and fluid-inclusion zoning

  6. Operating characteristics of isocaloric fountain-effect pumps

    Science.gov (United States)

    Kittel, Peter

    1988-01-01

    The governing equations of thermomechanical (fountain-effect) pumps are usually given for pumps operating at a constant temperature difference. These are the thermomechanical and mechanocaloric effects in which the pressure head and mass flow are independent of each other. Here, these equations are recast for a pump operating at a constant heat input (isocaloric). This form more closely represents how such pumps are likely to be used. Under these conditions, the pressure head and mass flow are shown to be related. For ideal pumps, the head and flow are related by a universal curve. For real pumps (those that have normal fluid leakage), a family of curves is developed. These curves approach the curve for an ideal pump at high flow rates. The isocaloric equations are also extended to multistage pumps.

  7. Vegetation survey of PEN Branch wetlands

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    A survey was conducted of vegetation along Pen Branch Creek at Savannah River Site (SRS) in support of K-Reactor restart. Plants were identified to species by overstory, understory, shrub, and groundcover strata. Abundance was also characterized and richness and diversity calculated. Based on woody species basal area, the Pen Branch delta was the most impacted, followed by the sections between the reactor and the delta. Species richness for shrub and groundcover strata were also lowest in the delta. No endangered plant species were found. Three upland pine areas were also sampled. In support of K Reactor restart, this report summarizes a study of the wetland vegetation along Pen Branch. Reactor effluent enters Indian Grove Branch and then flows into Pen Branch and the Pen Branch Delta.

  8. Application of Video Spectral Comparator (absorption spectra) for establishing the chronological order of intersecting printed strokes and writing pen strokes.

    Science.gov (United States)

    Kaur, Ridamjeet; Saini, Komal; Sood, N C

    2013-06-01

    The sequence of intersecting strokes of laser printers (black, blue, red and green) and typewriter ink (black) with the strokes of gel pen ink, ballpoint pen ink and fountain pen ink (black, blue, red and green) has been determined by studying their absorption spectra. The absorption spectra have been generated for each of the two pure inks (i.e. A and B) and points of their intersections (i.e. A over B and B over A) by using Video Spectral Comparator (VSC-2000-HR). The study was carried out with an assumption that the peak characteristics of spectra from the point of intersection should correspond to the peak characteristics of pure ink which was executed later. It was observed that the absorption spectrum of intersection corresponds with either the laser printer or the typewriter ink stroke, whether these strokes were executed earlier or later than the writing instrument strokes. As the results obtained from the study were negative, the FDEs are advised against the practice of this technique in the examination of the sequence of intersecting strokes for these specified inks.

  9. Improvements and New Evaluation of NIM4 Caesium Fountain Clock at NIM in 2005-2006

    Institute of Scientific and Technical Information of China (English)

    LI Tian-Chu; LI Ming-Shou; LIN Ping-Wei; WANG Ping; CHEN Wei-Liang; LIU Nian-Feng; LIN Yi-Ge

    2007-01-01

    The NIM4 caesium fountain clock has been operating stably and sub-continually since August 2003. We present our improvements on NIM4 in 2005-06 and the most recent evaluation for its frequency shifts with an uncertainty of 5×10-15. A 203-day comparison between NIM4 and GPS time shows an agreement of 2×10-14. Finally the construction of the NIM5 transportable caesium fountain clock is briefly reported.

  10. Study of cell migration in microfabricated channels.

    Science.gov (United States)

    Vargas, Pablo; Terriac, Emmanuel; Lennon-Duménil, Ana-Maria; Piel, Matthieu

    2014-02-21

    The method described here allows the study of cell migration under confinement in one dimension. It is based on the use of microfabricated channels, which impose a polarized phenotype to cells by physical constraints. Once inside channels, cells have only two possibilities: move forward or backward. This simplified migration in which directionality is restricted facilitates the automatic tracking of cells and the extraction of quantitative parameters to describe cell movement. These parameters include cell velocity, changes in direction, and pauses during motion. Microchannels are also compatible with the use of fluorescent markers and are therefore suitable to study localization of intracellular organelles and structures during cell migration at high resolution. Finally, the surface of the channels can be functionalized with different substrates, allowing the control of the adhesive properties of the channels or the study of haptotaxis. In summary, the system here described is intended to analyze the migration of large cell numbers in conditions in which both the geometry and the biochemical nature of the environment are controlled, facilitating the normalization and reproducibility of independent experiments.

  11. Research highlights: printing the future of microfabrication.

    Science.gov (United States)

    Tseng, Peter; Murray, Coleman; Kim, Donghyuk; Di Carlo, Dino

    2014-05-07

    In this issue we highlight emerging microfabrication approaches suitable for microfluidic systems with a focus on "additive manufacturing" processes (i.e. printing). In parallel with the now-wider availability of low cost consumer-grade 3D printers (as evidenced by at least three brands of 3D printers for sale in a recent visit to an electronics store in Akihabara, Tokyo), commercial-grade 3D printers are ramping to higher and higher resolution with new capabilities, such as printing of multiple materials of different transparency, and with different mechanical and electrical properties. We highlight new work showing that 3D printing (stereolithography approaches in particular) has now risen as a viable technology to print whole microfluidic devices. Printing on 2D surfaces such as paper is an everyday experience, and has been used widely in analytical chemistry for printing conductive materials on paper strips for glucose and other electrochemical sensors. We highlight recent work using electrodes printed on paper for digital microfluidic droplet actuation. Finally, we highlight recent work in which printing of membrane-bound droplets that interconnect through bilayer membranes may open up an entirely new approach to microfluidic manufacturing of soft devices that mimic physiological systems.

  12. Microfabricated adhesive mimicking gecko foot-hair

    Science.gov (United States)

    Geim, A. K.; Dubonos, S. V.; Grigorieva, I. V.; Novoselov, K. S.; Zhukov, A. A.; Shapoval, S. Yu.

    2003-07-01

    The amazing climbing ability of geckos has attracted the interest of philosophers and scientists alike for centuries. However, only in the past few years has progress been made in understanding the mechanism behind this ability, which relies on submicrometre keratin hairs covering the soles of geckos. Each hair produces a miniscule force ~10-7 N (due to van der Waals and/or capillary interactions) but millions of hairs acting together create a formidable adhesion of ~10 N cm-2: sufficient to keep geckos firmly on their feet, even when upside down on a glass ceiling. It is very tempting to create a new type of adhesive by mimicking the gecko mechanism. Here we report on a prototype of such 'gecko tape' made by microfabrication of dense arrays of flexible plastic pillars, the geometry of which is optimized to ensure their collective adhesion. Our approach shows a way to manufacture self-cleaning, re-attachable dry adhesives, although problems related to their durability and mass production are yet to be resolved.

  13. Microfabrication of microchannels for fuel cell plates.

    Science.gov (United States)

    Jang, Ho Su; Park, Dong Sam

    2010-01-01

    Portable electronic devices such as notebook computers, PDAs, cellular phones, etc., are being widely used, and they increasingly need cheap, efficient, and lightweight power sources. Fuel cells have been proposed as possible power sources to address issues that involve energy production and the environment. In particular, a small type of fuel-cell system is known to be suitable for portable electronic devices. The development of micro fuel cell systems can be achieved by the application of microchannel technology. In this study, the conventional method of chemical etching and the mechanical machining method of micro end milling were used for the microfabrication of microchannel for fuel cell separators. The two methods were compared in terms of their performance in the fabrication with regards to dimensional errors, flatness, straightness, and surface roughness. Following microchannel fabrication, the powder blasting technique is introduced to improve the coating performance of the catalyst on the surface of the microchannel. Experimental results show that end milling can remarkably increase the fabrication performance and that surface treatment by powder blasting can improve the performance of catalyst coating.

  14. Microfabricated instrument for tissue biopsy and analysis

    Science.gov (United States)

    Krulevitch, Peter A.; Lee, Abraham P.; Northrup, M. Allen; Benett, William J.

    1999-01-01

    A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 .mu.m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a "cheese-grater" style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate. For automation purposes, microvalves and micropumps may be incorporated. Also, specimens in parallel may be cut and treated with identical or varied chemicals. The instrument is disposable due to its low cost and thus could replace current expensive microtome and histology equipment.

  15. Study of Cell Migration in Microfabricated Channels

    Science.gov (United States)

    Vargas, Pablo; Terriac, Emmanuel; Lennon-Duménil, Ana-Maria; Piel, Matthieu

    2014-01-01

    The method described here allows the study of cell migration under confinement in one dimension. It is based on the use of microfabricated channels, which impose a polarized phenotype to cells by physical constraints. Once inside channels, cells have only two possibilities: move forward or backward. This simplified migration in which directionality is restricted facilitates the automatic tracking of cells and the extraction of quantitative parameters to describe cell movement. These parameters include cell velocity, changes in direction, and pauses during motion. Microchannels are also compatible with the use of fluorescent markers and are therefore suitable to study localization of intracellular organelles and structures during cell migration at high resolution. Finally, the surface of the channels can be functionalized with different substrates, allowing the control of the adhesive properties of the channels or the study of haptotaxis. In summary, the system here described is intended to analyze the migration of large cell numbers in conditions in which both the geometry and the biochemical nature of the environment are controlled, facilitating the normalization and reproducibility of independent experiments. PMID:24637569

  16. Microfabrication of Microchannels for Fuel Cell Plates

    Directory of Open Access Journals (Sweden)

    Ho Su Jang

    2009-12-01

    Full Text Available Portable electronic devices such as notebook computers, PDAs, cellular phones, etc., are being widely used, and they increasingly need cheap, efficient, and lightweight power sources. Fuel cells have been proposed as possible power sources to address issues that involve energy production and the environment. In particular, a small type of fuel-cell system is known to be suitable for portable electronic devices. The development of micro fuel cell systems can be achieved by the application of microchannel technology. In this study, the conventional method of chemical etching and the mechanical machining method of micro end milling were used for the microfabrication of microchannel for fuel cell separators. The two methods were compared in terms of their performance in the fabrication with regards to dimensional errors, flatness, straightness, and surface roughness. Following microchannel fabrication, the powder blasting technique is introduced to improve the coating performance of the catalyst on the surface of the microchannel. Experimental results show that end milling can remarkably increase the fabrication performance and that surface treatment by powder blasting can improve the performance of catalyst coating.

  17. Negative Ion Sources: Magnetron and Penning

    CERN Document Server

    Faircloth, D C

    2013-01-01

    The history of the magnetron and Penning electrode geometry is briefly outlined. Plasma generation by electrical discharge-driven electron impact ionization is described and the basic physics of plasma and electrodes relevant to magnetron and Penning discharges are explained. Negative ions and their applications are introduced, along with their production mechanisms. Caesium and surface production of negative ions are detailed. Technical details of how to build magnetron and Penning surface plasma sources are given, along with examples of specific sources from around the world. Failure modes are listed and lifetimes compared.

  18. Scanning Electron Microscopy and Petrography of Glassy Particles Produced by Lava Fountain Eruptions. Ph.D. Thesis - Final Report

    Science.gov (United States)

    Ladle, G. H.

    1978-01-01

    A conceptual model of a lava fountain consists of a vent, spatter ramparts, fountain column, downwind plume and associated pumice deposits. Glassy particles produced by lava fountain eruptions consist primarily of sideromelane glass and minor to moderate amounts of vesicles and crystals. Particles are classified on the basis of morphology as: (1) spherical, (2) elongate, (3) glass-coated mineral grain, (4) shard, (5) reticulite, (6) composite particle, and (7) lithic fragment.

  19. Telomeres and telomerase: a modern fountain of youth?

    Science.gov (United States)

    de Magalhães, João Pedro; Toussaint, Olivier

    2004-01-01

    Since ageing is a universal human feature, it is not surprising that, from the Babylonian epic of Gilgamesh to Ponce de Leon seeking the "Fountain of Youth," countless people have dreamed of finding a way to avoid ageing, to no avail. Yet the search continues. In this review, we present one of the latest candidates: the enzyme telomerase, capable of elongating the tips of chromosomes, the telomeres. Research into the causes of cellular ageing established the telomeres as the molecular clock that counts the number of times cells divide and triggers cellular senescence. Herein, we review arguments both in favor and against the use of telomerase as an anti-ageing therapy. The importance of the telomeres in cellular ageing, the low or non-existent levels of telomerase activity in human tissues, and the ability of telomerase to immortalize human cells suggest that telomerase can be used as an anti-ageing therapy. On the other hand, recent experiments in mice have raised doubts whether telomerase affects organismal ageing. Results from human cells expressing telomerase have also suggested telomerase may promote tumorigenesis. We conclude that, though telomerase may be used in regenerative medicine and to treat specific diseases, it is unlikely to become a source of anti-ageing therapies.

  20. Biotechnology workshops for secondary education: antioxidants, the fountain of youth?

    Directory of Open Access Journals (Sweden)

    Diorge Jônatas Marmitt

    2016-12-01

    Full Text Available Theory and practice about biotechnology-related issues have been topics of workshops for students and teachers of the Post Graduate in Biotechnology UNIVATES to secondary education students. We held ten different workshops aimed at the food production and health, among which stands out in this study, the workshop entitled "Antioxidants: the fountain of youth?", which evaluated the antioxidant potential of natural juice orange select and pearl pineapple. Previously, a protocol was structured on the practice, which aimed to evaluate the juice antioxidant potential of the fruit orange select and pearl pineapple, which was compared with the antioxidant reference compound, ascorbic acid, with adaptations according to spectrophotometric method in vitro DPPH. The workshops about antioxidants have 180 minutes duration and have been taught by three monitors responsible for assisting students throughout the activity. The workshops involved 388 students from seven schools in six municipalities of Taquari-RS Valley, and the workshop about antioxidants had 62 participants. This activity aimed to promote interaction and diffusion of knowledge among students of higher education and secondary education.

  1. Tips for Traveling with HomePEN

    Science.gov (United States)

    ... the Fullest Coping Strategies Emergency Preparedness Ideas & Products Restaurant/Bathroom Cards Swimming Travel Medical Air Transport Serivces ... experience a difficulties with your homePEN. For your convenience and peace of mind, Oley produces a complication ...

  2. Magnetic Torque of Microfabricated Elements and Magnetotactic Bacteria

    CERN Document Server

    Zondervan, Lars; Khalil, Islam S M; Pichel, Marc P; Misra, Sarthak; Abelmann, Leon

    2014-01-01

    We present a thorough theoretical analysis of the magnetic torque on microfabricated elements with dimensions in the range of 100 to 500 {\\mu}m and magneto-somes of magnetotactic bacteria of a few {\\mu}m length. We derive simple equations for field dependent torque and magnetic shape anisotropy that can be readily used to replace the crude approximations commonly used. We illustrate and verify the theory on microfabricated elements and magnetotactic bacteria, by field depedent torque magnetometry and by observing their rotation in water under application of a rotating magnetic field. The maximum rotation frequency of the largest microfabricated elements agrees within error boundaries with theory. For smaller, and especially thinner, elements the measured frequencies are a factor of three to four too low. We suspect this is caused by incomplete saturation of the magnetisation in the elements, which is not incorporated in our model. The maximum rotation frequency of magnetotactic bacteria agrees with our model ...

  3. Microfabricated Segmented-Involute-Foil Regenerator for Stirling Engines

    Science.gov (United States)

    Ibrahim, Mounir; Danila, Daniel; Simon, Terrence; Mantell, Susan; Sun, Liyong; Gedeon, David; Qiu, Songgang; Wood, Gary; Kelly, Kevin; McLean, Jeffrey

    2010-01-01

    An involute-foil regenerator was designed, microfabricated, and tested in an oscillating-flow test rig. The concept consists of stacked involute-foil nickel disks (see figure) microfabricated via a lithographic process. Test results yielded a performance of about twice that of the 90-percent random-fiber currently used in small Stirling converters. The segmented nature of the involute- foil in both the axial and radial directions increases the strength of the structure relative to wrapped foils. In addition, relative to random-fiber regenerators, the involute-foil has a reduced pressure drop, and is expected to be less susceptible to the release of metal fragments into the working space, thus increasing reliability. The prototype nickel involute-foil regenerator was adequate for testing in an engine with a 650 C hot-end temperature. This is lower than that required by larger engines, and high-temperature alloys are not suited for the lithographic microfabrication approach.

  4. Open-path FTIR spectroscopy of magma degassing processes during eight lava fountains on Mount Etna

    Science.gov (United States)

    La Spina, Alessandro; Burton, Mike; Allard, Patrick; Alparone, Salvatore; Murè, Filippo

    2016-04-01

    In June-July 2001 a series of 16 discrete lava fountain paroxysms occurred at the Southeast summit crater (SEC) of Mount Etna, preceding a 28-day long violent flank eruption. Each paroxysm was preceded by lava effusion, growing seismic tremor and a crescendo of Strombolian explosive activity culminating into powerful lava fountaining up to 500m in height. During 8 of these 16 events we could measure the chemical composition of the magmatic gas phase (H2O, CO2, SO2, HCl, HF and CO), using open-path Fourier transform infrared (OP-FTIR) spectrometry at ˜1-2km distance from SEC and absorption spectra of the radiation emitted by hot lava fragments. We show that each fountaining episode was characterized by increasingly CO2-rich gas release, with CO2/SO2and CO2/HCl ratios peaking in coincidence with maxima in seismic tremor and fountain height, whilst the SO2/HCl ratio showed a weak inverse relationship with respect to eruption intensity. Moreover, peak values in both CO2/SO2ratio and seismic tremor amplitude for each paroxysm were found to increase linearly in proportion with the repose interval (2-6 days) between lava fountains. These observations, together with a model of volatile degassing at Etna, support the following driving process. Prior to and during the June-July 2001 lava fountain sequence, the shallow (˜2km) magma reservoir feeding SEC received an increasing influx of deeply derived carbon dioxide, likely promoted by the deep ascent of volatile-rich primitive basalt that produced the subsequent flank eruption. This CO2-rich gas supply led to gas accumulation and overpressure in SEC reservoir, generating a bubble foam layer whose periodical collapse powered the successive fountaining events. The anti-correlation between SO2/HCl and eruption intensity is best explained by enhanced syn-eruptive degassing of chlorine from finer particles produced during more intense magma fragmentation.

  5. Pen- Name in Persian and Arabic Poetry

    Directory of Open Access Journals (Sweden)

    Ebrahim Khodayar

    2012-04-01

    Full Text Available Abstract Pen-name (Takhalloss is one of the main features of Persian poetry. It has been a matter of concern among many of Persian language geography poets in the orient at least up to the Mashrouteh era. Pen-name has been promoted among the other Muslim nations throuph Persian poetry. Although it is not as famous in the Arab nations as in the Persian speaking nations, it is known as “Alqab-o-shoara” among the Arab nations and, through this way, it has affected the poetrical wealth of the Arabic poets.   The Present paper, using description-analystic approach, compares the pen-names of Persian and Arabic poets under the title of “pen-names” and investigates their features in both cultures. The main research question is: What are the similarities and differences of poetic-names, in Persian and Arabic poets in terms of the type of name, position and importance? The results showed that Pseudonym by its amazing expansion in Persian poetry has also influenced Arabic poetry. In addition to the factors affecting in the choice of pen-names (like pseudonym, pen-name, nickname..., sometimes such external factors as events, commends, community benefactors and climate, as well as internal factors including the poets’ inner beliefs are associated too. .

  6. Marker Pen Lithography for Flexible and Curvilinear On-Chip Energy Storage

    KAUST Repository

    Jiang, Qiu

    2015-07-14

    On-chip energy storage using microsupercapacitors can serve the dual role of supplementing batteries for pulse power delivery, and replacement of bulky electrolytic capacitors in ac-line filtering applications. Despite complexity and processing costs, microfabrication techniques are being employed in fabricating a great variety of microsupercapacitor devices. Here, a simple, cost-effective, and versatile strategy is proposed to fabricate flexible and curvilinear microsupercapacitors (MSCs). The protocol involves writing sacrificial ink patterns using commercial marker pens on rigid, flexible, and curvilinear substrates. It is shown that this process can be used in both lift-off and etching modes, and the possibility of multistack design of active materials using simple pen lithography is demonstrated. As a prototype, this method is used to produce conducting polymer MSCs involving both poly(3,4-ethylenedioxythiophene), polyaniline, and metal oxide (MnO2) electrode materials. Typical values of energy density in the range of 5-11 mWh cm-3 at power densities of 1-6 W cm-3 are achieved, which is comparable to thin film batteries and superior to the carbon and metal oxide based microsupercapacitors reported in the literature. The simplicity and broad scope of this innovative strategy can open up new avenues for easy and scalable fabrication of a wide variety of on-chip energy storage devices. © 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

  7. Copper dimer interactions on a thermomechanical superfluid {sup 4}He fountain

    Energy Technology Data Exchange (ETDEWEB)

    Popov, Evgeny; Eloranta, Jussi, E-mail: Jussi.Eloranta@csun.edu [Department of Chemistry and Biochemistry, California State University at Northridge, 18111 Nordhoff St., Northridge, California 91330 (United States)

    2015-05-28

    Laser induced fluorescence imaging and frequency domain excitation spectroscopy of the copper dimer (B{sup 1}Σ{sub g}{sup +}←X{sup 1}Σ{sub u}{sup +}) in thermomechanical helium fountain at 1.7 K are demonstrated. The dimers penetrate into the fountain provided that their average propagation velocity is ca. 15 m/s. This energy threshold is interpreted in terms of an imperfect fountain liquid-gas interface, which acts as a trap for low velocity dimers. Orsay-Trento density functional theory calculations for superfluid {sup 4}He are used to characterize the dynamics of the dimer solvation process into the fountain. The dimers first accelerate towards the fountain surface and once the surface layer is crossed, they penetrate into the liquid and further slow down to Landau critical velocity by creating a vortex ring. Theoretical lineshape calculations support the assignment of the experimentally observed bands to Cu{sub 2} solvated in the bulk liquid. The vibronic progressions are decomposed of a zero-phonon line and two types of phonon bands, which correlate with solvent cavity interface compression (t < 200 fs) and expansion (200 < t < 500 fs) driven by the electronic excitation. The presented experimental method allows to perform molecular spectroscopy in bulk superfluid helium where the temperature and pressure can be varied.

  8. Microfabricated Silicon Microneedle Array for Transdermal Drug Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Ji, J [Mechanical Engineering National University of Singapore, 119260, Singapore (Singapore); Tay, F E [Mechanical Engineering National University of Singapore, 119260, Singapore (Singapore); Miao Jianmin [MicroMachines Center, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 (Singapore); Iliescu, C [Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Nanos, 04-01, 138669 (Singapore)

    2006-04-01

    This paper presents developed processes for silicon microneedle arrays microfabrication. Three types of microneedles structures were achieved by isotropic etching in inductively coupled plasma (ICP) using SF{sub 6}/O{sub 2} gases, combination of isotropic etching with deep etching, and wet etching, respectively. A microneedle array with biodegradable porous tips was further developed based on the fabricated microneedles.

  9. Microfabricated Silicon Microneedle Array for Transdermal Drug Delivery

    Science.gov (United States)

    Ji, Jing; Tay, Francis Eh; Miao, Jianmin; Iliescu, Ciprian

    2006-04-01

    This paper presents developed processes for silicon microneedle arrays microfabrication. Three types of microneedles structures were achieved by isotropic etching in inductively coupled plasma (ICP) using SF6/O2 gases, combination of isotropic etching with deep etching, and wet etching, respectively. A microneedle array with biodegradable porous tips was further developed based on the fabricated microneedles.

  10. Microfabricated palladium-based membranes for hydrogen separation

    NARCIS (Netherlands)

    Tong, Duy Hien

    2004-01-01

    The goal of this project was to fabricate thin and defect-free Pd-based membranes. This is thought to be accomplished by using techniques of microfabrication technology [60-62]. In order to show their potential, the fabricated membranes are then used as hydrogen purifiers to get high quality hydroge

  11. Concentrating Genomic Length DNA in a Microfabricated Array

    DEFF Research Database (Denmark)

    Chen, Yu; Abrams, Ezra S.; Boles, T. Christian

    2015-01-01

    We demonstrate that a microfabricated bump array can concentrate genomic-length DNA molecules efficiently at continuous, high flow velocities, up to 40 μm=s, if the single-molecule DNA globule has a sufficiently large shear modulus. Increase in the shear modulus is accomplished by compacting...

  12. Application of femtosecond laser pulses for microfabrication of transparent media

    Science.gov (United States)

    Juodkazis, S.; Matsuo, S.; Misawa, H.; Mizeikis, V.; Marcinkevicius, A.; Sun, H.-B.; Tokuda, Y.; Takahashi, M.; Yoko, T.; Nishii, J.

    2002-09-01

    Femtosecond laser microfabrication of 3D optical memories and photonic crystal (PhC) structures in solid glasses and liquid resins are demonstrated. The optical memories can be read out from both transmission and emission images. The PhC structures reveal clear signatures of photonic bandgap (PBG) and microcavity formation.

  13. Perceptions of Tap Water and School Water Fountains and Association with Intake of Plain Water and Sugar-Sweetened Beverages

    Science.gov (United States)

    Onufrak, Stephen J.; Park, Sohyun; Sharkey, Joseph R.; Merlo, Caitlin; Dean, Wesley R.; Sherry, Bettylou

    2014-01-01

    Background: Little is known regarding youth perceptions of tap water and school water fountains and how these relate to water and sugar-sweetened beverage (SSB) intake. Methods: We used national 2010 YouthStyles data to assess perceptions of tap water and school water fountains and associations with water and SSB intake. Results: Nearly 1 in 5…

  14. Eruption dynamics of Hawaiian-style fountains: The case study of episode 1 of the Kilauea Iki 1959 eruption

    Science.gov (United States)

    Stovall, W.K.; Houghton, B.F.; Gonnermann, H.; Fagents, S.A.; Swanson, D.A.

    2011-01-01

    Hawaiian eruptions are characterized by fountains of gas and ejecta, sustained for hours to days that reach tens to hundreds of meters in height. Quantitative analysis of the pyroclastic products from the 1959 eruption of K??lauea Iki, K??lauea volcano, Hawai'i, provides insights into the processes occurring during typical Hawaiian fountaining activity. This short-lived but powerful eruption contained 17 fountaining episodes and produced a cone and tephra blanket as well as a lava lake that interacted with the vent and fountain during all but the first episode of the eruption, the focus of this paper. Microtextural analysis of Hawaiian fountaining products from this opening episode is used to infer vesiculation processes within the fountain and shallow conduit. Vesicle number densities for all clasts are high (106-107 cm-3). Post-fragmentation expansion of bubbles within the thermally-insulated fountain overprints the pre-fragmentation bubble populations, leading to a reduction in vesicle number density and increase in mean vesicle size. However, early quenched rims of some clasts, with vesicle number densities approaching 107 cm-3, are probably a valid approximation to magma conditions near fragmentation. The extent of clast evolution from low vesicle-to-melt ratio and corresponding high vesicle number density to higher vesicle-to-melt ratio and lower vesicle-number density corresponds to the length of residence time within the fountain. ?? 2010 Springer-Verlag.

  15. Fountain Set Limited Launched New Products of 2011 Autumn-Winter Collections: Eco-friendliness and Multi-category

    Institute of Scientific and Technical Information of China (English)

    LiuYi

    2010-01-01

    @@ Fountain Set Limited announced that its branch brand "Fountain Set" was producing 2011 autumn-winter collections on the 2010 Intertextile Shanghai Apparel Fabrics Trade Fair, displaying new products embraced the concept of environment-friendliness, comfort and special functions like T400, Apexa, Bamboo textile, and a preview of its autumn-winter apparel fabrics was also provided.

  16. A NOVEL APPROACH OF LIMITED-RANDOMNESS FOUNTAIN CODES IN DEEP SPACE COMMUNICATION

    Institute of Scientific and Technical Information of China (English)

    Gu Shushi; Zhang Qinyu; Jiao Jian

    2011-01-01

    Digital fountain is applied into deep space communication for its rateless and non-feedback forward error correction.However,the long code length and encoding overhead are confined factors to guarantee a considerable recovery probability as power and buffer-limited equipment in deep space environment.At the same time,the typical fountain decoding is sub-optimum decoding algorithm.We propose a new approach,Dependent Sequences Compensation Algorithm (DSCA),to improve the encoding efficiency by restricting the randomness in fountain encoding.While decoding algorithm is also optimized by redundant information in stopping set.The results show that the optimized method can obtain a 10-4 decoding failure rate with overhead under 0.20 for code length 500,which indicates the usefulness of the proposed approach in deep space communication.

  17. Loading of a fountain clock with an enhanced Low-Velocity Intense Source of atoms

    CERN Document Server

    Dobrev, Georgi; Weyers, Stefan

    2016-01-01

    We present experimental work for improved atom loading in the optical molasses of a caesium fountain clock, employing a low-velocity intense source of atoms (LVIS) [Lu et al., Phys. Rev. Lett. 77, 3331 (1996)], which we modified by adding a "dark" state pump laser. With this modification the atom source has a mean flux of $4 \\times 10^{8}$ atoms/s at a mean atom velocity of $8.6$ m/s. Compared to fountain operation using background gas loading, we achieved a significant increase of the loaded and detected atom number by a factor of 40. Operating the fountain clock with a total number of detected atoms $N_{\\mathrm{at}}=2.9 \\times 10^6$ in the quantum projection noise-limited regime, a frequency instability $\\sigma_y\\left(1\\text{s}\\right)=2.7 \\times 10^{-14}$ was demonstrated.

  18. Fountain code-based error control scheme for dimmable visible light communication systems

    Science.gov (United States)

    Feng, Lifang; Hu, Rose Qingyang; Wang, Jianping; Xu, Peng

    2015-07-01

    In this paper, a novel error control scheme using Fountain codes is proposed in on-off keying (OOK) based visible light communications (VLC) systems. By using Fountain codes, feedback information is needed to be sent back to the transmitter only when transmitted messages are successfully recovered. Therefore improved transmission efficiency, reduced protocol complexity and relative little wireless link-layer delay are gained. By employing scrambling techniques and complementing symbols, the least complemented symbols are needed to support arbitrary dimming target values, and the value of entropy of encoded message are increased.

  19. On the Concatenation of Non-Binary Random Linear Fountain Codes with Maximum Distance Separable Codes

    CERN Document Server

    Blasco, Francisco Lazaro

    2011-01-01

    A novel fountain coding scheme has been introduced. The scheme consists of a parallel concatenation of a MDS block code with a LRFC code, both constructed over the same field, $F_q$. The performance of the concatenated fountain coding scheme has been analyzed through derivation of tight bounds on the probability of decoding failure as a function of the overhead. It has been shown how the concatenated scheme performs as well as LRFC codes in channels characterized by high erasure probabilities, whereas they provide failure probabilities lower by several orders of magnitude at moderate/low erasure probabilities.

  20. Demonstration of a Dual Alkali Rb/Cs Atomic Fountain Clock

    CERN Document Server

    Guéna, J; Laurent, Ph; Abgrall, M; Rovera, D; Lours, M; Santarelli, G; Tobar, M E; Bize, S; Clairon, A; 10.1109/TUFFC.2010.1461

    2013-01-01

    We report the operation of a dual Rb/Cs atomic fountain clock. 133Cs and 87Rb atoms are cooled, launched, and detected simultaneously in LNE-SYRTE's FO2 double fountain. The dual clock operation occurs with no degradation of either the stability or the accuracy. We describe the key features for achieving such a simultaneous operation. We also report on the results of the first Rb/Cs frequency measurement campaign performed with FO2 in this dual atom clock configuration, including a new determination of the absolute 87Rb hyperfine frequency.

  1. Pen-and-Paper User Interfaces

    CERN Document Server

    Steimle, Jurgen

    2012-01-01

    Even at the beginning of the 21st century, we are far from becoming paperless. Pen and paper is still the only truly ubiquitous information processing technology. Pen-and-paper user interfaces bridge the gap between paper and the digital world. Rather than replacing paper with electronic media, they seamlessly integrate both worlds in a hybrid user interface. Classical paper documents become interactive. This opens up a huge field of novel computer applications at our workplaces and in our homes. This book provides readers with a broad and extensive overview of the field, so as to provide a fu

  2. A Survey of Pen Name (Takhallos in Sonnets (Ghazals

    Directory of Open Access Journals (Sweden)

    Zohreh Ahmadipour

    2010-06-01

    Full Text Available Abstract   The pen name of poet appears in the end of the poem and it is spread from the end of Mogul period. Although before this period, some poets write their pen name in the final verse of the poem too. The literary Restoration Period poets follow Hafiz and saadi in Lyrics. they wanted to imitate their great teachers exactly. so they imitate these two poets in their pen name.   Mostly, the pen name is written in the final verse of the Sonnet, but some time, the poet write the pen name in the previous to last verse of Sonnet because of praising someone else or putting allegory in the final verse. Rarely poet didn't use his pen name in the poem, because of not finishing the poem or the poet did not want to use his name next to the praised name, sometimes they use pronoun "I" instead of their pen name. In this study, also we investigate the point of view in pen name amphibology in pen name, adjectives of pen name, and contents that use with it.   Also in this study pen name in sonnet (Ghazals of the literary Restoration Period are compared with pen name in hafiz and saadi Ghazals, so that the special manners of pen name applications in Lyrics of these two great master sonnet poets identified and the degree of imitation of others get in hand.

  3. Biodeterioration of the Lions Fountain at the Alhambra Palace, Granada (Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Sarro, M. Isabel; Garcia, Ana M.; Rivalta, Victor M.; Moreno, Diego A. [Universidad Politecnica de Madrid, Escuela Tecnica Superior de Ingenieros Industriales, Jose Gutierrez Abascal, Madrid (Spain). Departamento de Ingenieria y Ciencia de los Materiales; Arroyo, Irene [Instituto del Patrimonio Historico Espanol, Ministerio de Cultura, El Greco, Madrid (Spain)

    2006-12-15

    Stone works of art exposed to the environment are liable to be deteriorated by the action of biological agents such as bacteria, fungi, mosses, etc. In ornamental fountains, the microorganisms present in water can contribute to these biodeterioration processes. This paper assesses the biodeterioration experienced by the Lions Fountain at the Alhambra Palace in Granada (Spain). Analyses have been made of the biodeterioration of Lions 4, 5 and 9, the biofouling of the fountain basin, and the water supply system. Conventional and molecular biology techniques have identified microorganisms belonging to various microbial groups ({alpha}-, {beta}- and {gamma}-Protebacteria, Chlamydiae/Verrucomicrobia and Eukaryota). Additionally, on the mortar in the sculptures the presence of algae and bryophytes has been observed. X-ray diffraction allowed both the detection of neoformation mineral products that can be related with the presence of microorganisms and the corrosion products in the Lions Fountain. A number of recommendations are made regarding the prevention and control of biodeterioration in this important work of art. (author)

  4. Three-dimensional microfabrication through a multimode optical fiber

    CERN Document Server

    Morales-Delgado, Edgar E; Conkey, Donald B; Stasio, Nicolino; Psaltis, Demetri; Moser, Christophe

    2016-01-01

    Additive manufacturing, also known as 3D printing, is an advanced manufacturing technique that allows the fabrication of arbitrary macroscopic and microscopic objects. All 3D printing systems require large optical elements or nozzles in proximity to the built structure. This prevents their use in applications in which there is no direct access to the area where the objects have to be printed. Here, we demonstrate three-dimensional microfabrication based on two-photon polymerization (TPP) with sub diffraction-limited resolution through an ultra-thin, 50 mm long printing nozzle of 560 micrometers in diameter. Using wavefront shaping, femtosecond infrared pulses are focused and scanned through a multimode optical fiber (MMF) inside a photoresist that polymerizes via two-photon absorption. We show the construction of arbitrary 3D structures of 500 nm resolution on the other side of the fiber. To our knowledge, this is the first demonstration of microfabrication through a multimode optical fiber. Our work represen...

  5. Hydrogel microfabrication technology toward three dimensional tissue engineering

    Directory of Open Access Journals (Sweden)

    Fumiki Yanagawa

    2016-03-01

    Full Text Available The development of biologically relevant three-dimensional (3D tissue constructs is essential for the alternative methods of organ transplantation in regenerative medicine, as well as the development of improved drug discovery assays. Recent technological advances in hydrogel microfabrication, such as micromolding, 3D bioprinting, photolithography, and stereolithography, have led to the production of 3D tissue constructs that exhibit biological functions with precise 3D microstructures. Furthermore, microfluidics technology has enabled the development of the perfusion culture of 3D tissue constructs with vascular networks. In this review, we present these hydrogel microfabrication technologies for the in vitro reconstruction and cultivation of 3D tissues. Additionally, we discuss current challenges and future perspectives of 3D tissue engineering.

  6. Contact printed masks for 3D microfabrication in negative resists

    DEFF Research Database (Denmark)

    Häfliger, Daniel; Boisen, Anja

    2005-01-01

    We present a process based on contact printed shadow masks for three dimensional microfabrication of soft and sensitive overhanging membranes in SU-8. A metal mask is transferred onto unexposed SU-8 from an elastomer stamp made of polydimethylsiloxane. This mask is subsequently embedded into the ......We present a process based on contact printed shadow masks for three dimensional microfabrication of soft and sensitive overhanging membranes in SU-8. A metal mask is transferred onto unexposed SU-8 from an elastomer stamp made of polydimethylsiloxane. This mask is subsequently embedded...... into the negative resist to protect buried material from UV-exposure. Unlike direct evaporation-deposition of a mask onto the SU-8, printing avoids high stress and radiation, thus preventing resist wrinkling and prepolymerization. We demonstrate effective monolithic fabrication of soft, 4-μm thick and 100-μm long...

  7. In-Vacuum Electronics for Microfabricated Ion Traps

    CERN Document Server

    Guise, Nicholas D; Hayden, Harley; Pai, C-S; Volin, Curtis; Brown, K R; Merrill, J True; Harter, Alexa W; Amini, Jason M; Lust, Lisa M; Muldoon, Kelly; Carlson, Doug; Budach, Jerry

    2014-01-01

    The advent of microfabricated ion traps for the quantum information community has allowed research groups to build traps that incorporate an unprecedented number of trapping zones. However, as device complexity has grown, the number of digital-to-analog converter (DAC) channels needed to control these devices has grown as well, with some of the largest trap assemblies now requiring nearly one hundred DAC channels. Providing electrical connections for these channels into a vacuum chamber can be bulky and difficult to scale beyond the current numbers of trap electrodes. This paper reports on the development and testing of an in-vacuum DAC system that uses only 9 vacuum feedthrough connections to control a 78-electrode microfabricated ion trap. The system is characterized by trapping single and multiple $^{40}$Ca$^+$ ions. The measured axial mode stability, ion heating rates, and transport fidelities for a trapped ion are comparable to systems with external(air-side) National Instruments PXI-6733 DACs.

  8. Microfabricated platforms for the study of neuronal and cellular networks

    Energy Technology Data Exchange (ETDEWEB)

    Berdondini, L; Generelli, S; Kraus, T; Guenat, O T; Koster, S; Linder, V; Koudelka-Hep, M; Rooij, N F de [SAMLAB, Institute of Microtechnology, University of Neuchatel (Switzerland)

    2006-04-01

    In this contribution we present the development of three microfabricated devices for the study of neuronal and cellular networks. Together, these devices form an attractive toolbox, which is useful to stimulate and record signals of both electrical and chemical nature. One approach consist of microelectrode arrays for the study of neuronal networks, and allow for the electrical stimulation of individual cells in the network, while the other electrodes of the array record the electrical activity of the remaining cells of the network. We also present the use of micropipettes that can measure the extra- and intracellular concentrations of ions in cells cultures. A third approach exploits the laminar flows in a microfluidic device, to deliver minute amounts of drug to some cells in a cellular network. These three illustrations show that microfabricated platforms are appealing analytical tools in the context of cell biology.

  9. Determinants of Clay and Shale Microfabric Signatures: Processes and Mechanisms

    Science.gov (United States)

    1991-01-01

    extremely fast and others that progress over eons. As defined in this study, mechanisms are the specific energy sources that drive microfabric development...mechanisms that occur extremely fast and others acoustics, physical and historical geology, waste disposal, h’drol- that progress over cons. As defined in...proteroroic microbiota oft the Nlictia Bit% les. I- A . W Rt Br nt. andi C Wallin. 1969. Microiructure of unconqoli- (Group. Southern British

  10. Bimetallic Thermal Resists for Photomask, Micromachining and Microfabrication

    OpenAIRE

    Tu, Richard Yuqiang

    2004-01-01

    Photoresists and photomasks are two of the most critical materials in microfabrication and micromachining industries. As the shift towards shorter wavelength exposure continues, conventional organic photoresists and chromelquartz photomasks start to encounter problems. This thesis investigates and presents an alternative to organic photoresists and chromium photomasks which overcomes their intrinsic problems. A bimetallic thin film, such as BilIn and SnIIn, creates an inorganic thermal resist...

  11. Practical, microfabrication-free device for single-cell isolation.

    Directory of Open Access Journals (Sweden)

    Liang-I Lin

    Full Text Available Microfabricated devices have great potential in cell-level studies, but are not easily accessible for the broad biology community. This paper introduces the Microscale Oil-Covered Cell Array (MOCCA as a low-cost device for high throughput single-cell analysis that can be easily produced by researchers without microengineering knowledge. Instead of using microfabricated structures to capture cells, MOCCA isolates cells in discrete aqueous droplets that are separated by oil on patterned hydrophilic areas across a relatively more hydrophobic substrate. The number of randomly seeded Escherichia coli bacteria in each discrete droplet approaches single-cell levels. The cell distribution on MOCCA is well-fit with Poisson distribution. In this pioneer study, we created an array of 900-picoliter droplets. The total time needed to seed cells in approximately 3000 droplets was less than 10 minutes. Compared to traditional microfabrication techniques, MOCCA dramatically lowers the cost of microscale cell arrays, yet enhances the fabrication and operational efficiency for single-cell analysis.

  12. Pen of Health Care Worker as Vector of Infection

    Directory of Open Access Journals (Sweden)

    Prashant Patil

    2010-10-01

    Full Text Available Nosocomial infections are the major concern in tertiary hospitals. Health care workers and their belonging are known to act as vector in transmission of infections. In present study, the writing pen of health care workers was worked out for carrying infection. The swab from writing pen of health care workers were cultured for any growth of microorganism and compared with swab from pen of the non health care workers. It was found that the rate of growth of microorganism were more in pen of health care workers. Similarly the organism attributed to the nosocomial infection was grown from the pens of health care workers. These organisms might be transmitted from the hands of health care workers. The writing pen which health care worker are using became the vectors of transmission of infection. So to prevent it, the most important way is to wash the hands and pen properly after examining the patients.

  13. Damping effects in Penning trap mass spectrometry

    CERN Document Server

    George, S; Kowalska, M; Dworschak, M; Neidherr, D; Blaum, K; Schweikhard, L; Ramirez, E M; Breitenfeldt, M; Kretzschmar, M; Herfurth, F; Schwarz, S; Herlert, A

    2011-01-01

    Collisions of ions with residual gas atoms in a Penning trap can have a strong influence on the trajectories of the ions, depending on the atom species and the gas pressure. We report on investigations of damping effects in time-of-flight ion-cyclotron resonance mass spectrometry with the Penning trap mass spectrometers ISOLTRAP at ISOLDE/CERN (Geneva, Switzerland) and SHIPTRAP at GSI (Darmstadt, Germany). The work focuses on the interconversion of the magnetron and cyclotron motional modes, in particular the modification of the resonance profiles for quadrupolar excitation due to the damping effect of the residual gas. Extensive experiments have been performed with standard and Ramsey excitation schemes. The results are in good agreement with predictions obtained by analytical continuation of the formulae for the undamped case.

  14. Nonlinear PIC simulation in a Penning trap

    Science.gov (United States)

    Lapenta, G.; Delzanno, G. L.; Finn, J. M.

    2002-01-01

    We study the nonlinear dynamics of a Penning trap plasma, including the effect of the finite length and end curvature of the plasma column. A new cylindrical PIC code, called KANDINSKY, has been implemented by using a new interpolation scheme. The principal idea is to calculate the volume of each cell from a particle volume, in the same manner as it is done for the cell charge. With this new method, the density is conserved along streamlines and artificial sources of compressibility are avoided. The code has been validated with a reference Eulerian fluid code. We compare the dynamics of three different models: a model with compression effects, the standard Euler model and a geophysical fluid dynamics model. The results of our investigation prove that Penning traps can really be used to simulate geophysical fluids.

  15. Liquid-Phase Beam Pen Lithography.

    Science.gov (United States)

    He, Shu; Xie, Zhuang; Park, Daniel J; Liao, Xing; Brown, Keith A; Chen, Peng-Cheng; Zhou, Yu; Schatz, George C; Mirkin, Chad A

    2016-02-24

    Beam pen lithography (BPL) in the liquid phase is evaluated. The effect of tip-substrate gap and aperture size on patterning performance is systematically investigated. As a proof-of-concept experiment, nanoarrays of nucleotides are synthesized using BPL in an organic medium, pointing toward the potential of using liquid phase BPL to perform localized photochemical reactions that require a liquid medium. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Maximum Likelihood Analysis in the PEN Experiment

    Science.gov (United States)

    Lehman, Martin

    2013-10-01

    The experimental determination of the π+ -->e+ ν (γ) decay branching ratio currently provides the most accurate test of lepton universality. The PEN experiment at PSI, Switzerland, aims to improve the present world average experimental precision of 3 . 3 ×10-3 to 5 ×10-4 using a stopped beam approach. During runs in 2008-10, PEN has acquired over 2 ×107 πe 2 events. The experiment includes active beam detectors (degrader, mini TPC, target), central MWPC tracking with plastic scintillator hodoscopes, and a spherical pure CsI electromagnetic shower calorimeter. The final branching ratio will be calculated using a maximum likelihood analysis. This analysis assigns each event a probability for 5 processes (π+ -->e+ ν , π+ -->μ+ ν , decay-in-flight, pile-up, and hadronic events) using Monte Carlo verified probability distribution functions of our observables (energies, times, etc). A progress report on the PEN maximum likelihood analysis will be presented. Work supported by NSF grant PHY-0970013.

  17. Test on qualitative improvement of reservoir water by fountain. Funsui ni yoru chosuichi suishitsu kaizen no kokoromi

    Energy Technology Data Exchange (ETDEWEB)

    Miyanaga, Y.; Toyota, K. (Central Research Institute of Electric Power Co. Inc., Osaka (Japan)); Kimura, M. (The Chugoku Electric Power Co. Inc., Hiroshima (Japan))

    1993-11-30

    Qualitative improvement of water was tested by fountain as measures for enriching the water reservoir with nurture. Moored at a bank which was 5km upstream from the dam, a fountain unit sucked cold water at a water depth of 10m. Then, a region of 35m in diameter was sprayed with it by 32 nozzles. The flow rate was 5.0m[sup 3]/min. In the region of 30m in distance from the unit, it was confirmed from the experiment that the largest drop in water temperature and that in concentration of chlorophyll-a were 0.9 centigrade and 4.0mg/m[sup 3], respectively. It was also known that a flow existed at a 1m-waterdeep spot which was 20m distant from the unit. Judging from the above, the water was qualitatively improved by the fountain as far as 30m in radius. The field experiment was analyzed by a numerical analysis model which treated the fountain flow as a two-dimensional axially symmetric flow. It was confirmed that the change in water temperature and flow can be roughly evaluated, if the oblique incidence of fountain flow is taken into consideration. It was also known that the fountain flow converges in a 1 to 2m-waterdeep surface layer. Though there is a possibility of amplifying the region to be influenced, it is not a specifically effective method. 5 refs., 10 figs., 2 tabs.

  18. Status of the atomic fountain clock at the National Research Council of Canada

    Science.gov (United States)

    Beattie, S.; Alcock, J.; Jian, B.; Gertsvolf, M.; Bernard, J.

    2016-06-01

    Despite the rapid advances in optical frequency standards, caesium fountain clocks retain a critical role as the most accurate primary frequency standards available. At the National Research Council Canada, we are working to develop a second generation caesium fountain clock. Work is currently underway to improve several systems of FCs1, such as the laser system and microwave local oscillator, which will be incorporated into its refurbished version, FCs2. In addition, we have added an optical pumping stage which has increased the detected atom number by over a factor of six. In collaboration with the National Physical Laboratory (NPL), we are planning on replacing the physics package of FCs1. We will report on several recent improvements to FCs1, along with our progress in the development of FCs2.

  19. In situ x-ray diffraction measurements of the capillary fountain jet produced via ultrasonic atomization

    Science.gov (United States)

    Yano, Yohko F.; Douguchi, Junya; Kumagai, Atsushi; Iijima, Takao; Tomida, Yukinobu; Miyamoto, Toshiaki; Matsuura, Kazuo

    2006-11-01

    In situ x-ray diffraction measurements were carried out for investigating the liquid structure in the ultrasonic fountain jet to consider the mechanism of the "ultrasonic ethanol separation" reported by Sato et al. [J. Chem. Phys. 114, 2382 (2001)]. For pure liquids (water and ethanol), it was found that the high frequency ultrasound does not affect the liquid structure microscopically. For the 20mol% ethanol-water mixture, the estimated ethanol mole fraction in the ultrasonic fountain jet by using the position of the main maximum in the x-ray diffraction profile coincided with that in the reservoir. This result suggests that the ethanol separation is not caused by any distorted liquid structure under the ultrasound irradiation and occurs when or after the generation of the liquid droplet mist.

  20. Towards increasing diversity for the relaying of LT Fountain Codes in Wireless Sensor Networks

    CERN Document Server

    Anya, Apavatjrut; Jaffrès-Runser, Katia; Comaniciu, Cristina; Gorce, Jean-Marie

    2010-01-01

    Diversity is a powerful means to increase the transmission performance of wireless communications. For the case of fountain codes relaying, it has been shown previously that introducing diversity is also beneficial since it counteracts transmission losses on the channel. Instead of simply hop-by-hop forwarding information, each sensor node diversifies the information flow using XOR combinations of stored packets. This approach has been shown to be efficient for random linear fountain codes. However, random linear codes exhibit high decoding complexity. In this paper, we propose diversity increased relaying strategies for the more realistic Luby Transform code in order to maintain high transmission performance with low decoding computational complexity in a linear network. Results are provided herein for a linear network assuming uniform imperfect channel states.

  1. A microfabrication-based approach to quantitative isothermal titration calorimetry.

    Science.gov (United States)

    Wang, Bin; Jia, Yuan; Lin, Qiao

    2016-04-15

    Isothermal titration calorimetry (ITC) directly measures heat evolved in a chemical reaction to determine equilibrium binding properties of biomolecular systems. Conventional ITC instruments are expensive, use complicated design and construction, and require long analysis times. Microfabricated calorimetric devices are promising, although they have yet to allow accurate, quantitative ITC measurements of biochemical reactions. This paper presents a microfabrication-based approach to integrated, quantitative ITC characterization of biomolecular interactions. The approach integrates microfabricated differential calorimetric sensors with microfluidic titration. Biomolecules and reagents are introduced at each of a series of molar ratios, mixed, and allowed to react. The reaction thermal power is differentially measured, and used to determine the thermodynamic profile of the biomolecular interactions. Implemented in a microdevice featuring thermally isolated, well-defined reaction volumes with minimized fluid evaporation as well as highly sensitive thermoelectric sensing, the approach enables accurate and quantitative ITC measurements of protein-ligand interactions under different isothermal conditions. Using the approach, we demonstrate ITC characterization of the binding of 18-Crown-6 with barium chloride, and the binding of ribonuclease A with cytidine 2'-monophosphate within reaction volumes of approximately 0.7 µL and at concentrations down to 2mM. For each binding system, the ITC measurements were completed with considerably reduced analysis times and material consumption, and yielded a complete thermodynamic profile of the molecular interaction in agreement with published data. This demonstrates the potential usefulness of our approach for biomolecular characterization in biomedical applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Beverages obtained from soda fountain machines in the U.S. contain microorganisms, including coliform bacteria.

    Science.gov (United States)

    White, Amy S; Godard, Renee D; Belling, Carolyn; Kasza, Victoria; Beach, Rebecca L

    2010-01-31

    Ninety beverages of three types (sugar sodas, diet sodas and water) were obtained from 20 self-service and 10 personnel-dispensed soda fountains, analyzed for microbial contamination, and evaluated with respect to U.S. drinking water regulations. A follow-up study compared the concentration and composition of microbial populations in 27 beverages collected from 9 soda fountain machines in the morning as well as in the afternoon. Ice dispensed from these machines was also examined for microbial contamination. While none of the ice samples exceeded U.S. drinking water standards, coliform bacteria was detected in 48% of the beverages and 20% had a heterotrophic plate count greater than 500cfu/ml. Statistical analyses revealed no difference in levels of microbial contamination between beverage types or between those dispensed from self-service and personnel-dispensed soda fountains. More than 11% of the beverages analyzed contained Escherichia coli and over 17% contained Chryseobacterium meningosepticum. Other opportunistic pathogenic microorganisms isolated from the beverages included species of Klebsiella, Staphylococcus, Stenotrophomonas, Candida, and Serratia. Most of the identified bacteria showed resistance to one or more of the 11 antibiotics tested. These findings suggest that soda fountain machines may harbor persistent communities of potentially pathogenic microorganisms which may contribute to episodic gastric distress in the general population and could pose a more significant health risk to immunocompromised individuals. These findings have important public health implications and signal the need for regulations enforcing hygienic practices associated with these beverage dispensers. Copyright 2009 Elsevier B.V. All rights reserved.

  3. Non-Linear Dependence of the Height of a Chain Fountain on Drop Height

    Science.gov (United States)

    Andrew, Y.; Kearns, F.; Mustafa, T.; Salih, R.; Ioratim-Uba, A.; Udall, I.; Usama, M.

    2015-01-01

    If the end of a long chain, which is contained in an elevated beaker, is dropped over the edge of the beaker and falls, it is observed that as the speed of the chain increases the chain rises to form a loop well above the top of the beaker. The name "chain fountain" has been applied to this phenomenon. In this study the dependence of the…

  4. First international comparison of fountain primary frequency standards via a long distance optical fiber link

    Science.gov (United States)

    Guéna, J.; Weyers, S.; Abgrall, M.; Grebing, C.; Gerginov, V.; Rosenbusch, P.; Bize, S.; Lipphardt, B.; Denker, H.; Quintin, N.; Raupach, S. M. F.; Nicolodi, D.; Stefani, F.; Chiodo, N.; Koke, S.; Kuhl, A.; Wiotte, F.; Meynadier, F.; Camisard, E.; Chardonnet, C.; Le Coq, Y.; Lours, M.; Santarelli, G.; Amy-Klein, A.; Le Targat, R.; Lopez, O.; Pottie, P. E.; Grosche, G.

    2017-06-01

    We report on the first comparison of distant caesium fountain primary frequency standards (PFSs) via an optical fiber link. The 1415 km long optical link connects two PFSs at LNE-SYRTE (Laboratoire National de métrologie et d’Essais—SYstème de Références Temps-Espace) in Paris (France) with two at PTB (Physikalisch-Technische Bundesanstalt) in Braunschweig (Germany). For a long time, these PFSs have been major contributors to accuracy of the International Atomic Time (TAI), with stated accuracies of around 3× {{10}-16} . They have also been the references for a number of absolute measurements of clock transition frequencies in various optical frequency standards in view of a future redefinition of the second. The phase coherent optical frequency transfer via a stabilized telecom fiber link enables far better resolution than any other means of frequency transfer based on satellite links. The agreement for each pair of distant fountains compared is well within the combined uncertainty of a few 10-16 for all the comparisons, which fully supports the stated PFSs’ uncertainties. The comparison also includes a rubidium fountain frequency standard participating in the steering of TAI and enables a new absolute determination of the 87Rb ground state hyperfine transition frequency with an uncertainty of 3.1× {{10}-16} . This paper is dedicated to the memory of André Clairon, who passed away on 24 December 2015, for his pioneering and long-lasting efforts in atomic fountains. He also pioneered optical links from as early as 1997.

  5. Magnetic separation in microfluidic systems using microfabricated electromagnets - Experiments and simulations

    DEFF Research Database (Denmark)

    Smistrup, Kristian; Hansen, Ole; Bruus, Henrik;

    2005-01-01

    We present experiments and simulations of magnetic separation of magnetic beads in a microfluidic channel. The separation is obtained by microfabricated electromagnets. The results of our simulations using FEMLAB and Mathematica are compared with experimental results obtained using our own microf...... microfabricated systems. (c) 2005 Elsevier B.V. All rights reserved....

  6. Microfabricated palladium-silver alloy membranes and their application in hydrogen separation

    NARCIS (Netherlands)

    Tong, H.D.; Gielens, F.C.; Gardeniers, J.G.E.; Jansen, H.V.; Rijn, van C.J.M.; Elwenspoek, M.C.; Nijdam, W.

    2004-01-01

    A submicron-thick and defect-free palladium-silver (Pd-Ag) alloy membrane is manufactured using microfabrication technology. The microfabrication process creates a robust wafer-scale membrane module, which can easily be integrated into a holder with gastight connections. High separation fluxes of up

  7. RD on 3D Sensors and MicroFabricated Systems

    CERN Document Server

    Da Via, C

    2013-01-01

    The aim of this proposed R&D Collaboration is the design, fabrication and industrialization of a new generation of low mass detector systems based on silicon micro-fabrication techniques. The main objective is the validation of such systems in HL-LHC detectors upgrades. In particular the collaboration would like to focus on the following research topics: • Novel 3D sensors layouts, with enhanced signal properties, high speed and active edges; •Integrated micro-channel cooling for effective low mass module thermal management; •System integration, simulation and reliability studies at experiments’ operational conditions.

  8. A planar microfabricated electrolyzer for hydrogen and oxygen generation

    Science.gov (United States)

    Jiang, L.; Myer, B.; Tellefsen, K.; Pau, S.

    We present the design, fabrication and testing of a microfabricated planar reactor for the hydrogen evolution reaction (HER) using thin film Pt electrodes and polydimethylsiloxane (PDMS) fluidic chamber. The reactor is designed to separate gases by flow dynamics and reactor flow is analyzed by three-dimensional finite element analysis. The planar geometry is scalable, compact and stackable. Using KOH 28 wt% electrolyte, we have achieved a hydrogen generation density of 0.23 kg h -1 m -3 and an efficiency of 48% with a flow rate of 10 ml min -1 and cell voltage of 3 V.

  9. Microfabrication and Applications of Opto-Microfluidic Sensors

    Directory of Open Access Journals (Sweden)

    Daiying Zhang

    2011-05-01

    Full Text Available A review of research activities on opto-microfluidic sensors carried out by the research groups in Canada is presented. After a brief introduction of this exciting research field, detailed discussion is focused on different techniques for the fabrication of opto-microfluidic sensors, and various applications of these devices for bioanalysis, chemical detection, and optical measurement. Our current research on femtosecond laser microfabrication of optofluidic devices is introduced and some experimental results are elaborated. The research on opto-microfluidics provides highly sensitive opto-microfluidic sensors for practical applications with significant advantages of portability, efficiency, sensitivity, versatility, and low cost.

  10. NPL Cs fountain frequency standards and the quest for the ultimate accuracy

    Science.gov (United States)

    Szymaniec, K.; Lea, S. N.; Gibble, K.; Park, S. E.; Liu, K.; Głowacki, P.

    2016-06-01

    NPL operates a system of two primary caesium fountain clocks consisting of a fully characterised standard NPL-CsF2 together with a new standard NPL-CsF3, which has recently become operational. Both fountains feature a single-stage vapour-loaded magneto-optical trap as the source of cold atoms and an approximate cancellation of the potentially large cold collision frequency shift. As a result, the collision-shift type-B uncertainty is less than 10-16. Subsequently, more subtle systematic effects, including the frequency shifts from distributed cavity phase, microwave lensing and collisions with background gas have also been evaluated at the level of 10-16 or below. Now, as several systematic effects contribute to the fountains’ uncertainty budgets similarly, further significant improvement of their accuracies is expected to be even more difficult. The short-term stability of these standards is also a significant factor limiting the overall precision as many days or even weeks of averaging is required for the type-A statistical uncertainty to approach the declared type-B systematic uncertainty. Going forward, further improvements in the reliability and robustness of operation of fountain standards is one of our priorities.

  11. Atomic fountain clock with very high frequency stability employing a pulse-tube-cryocooled sapphire oscillator.

    Science.gov (United States)

    Takamizawa, Akifumi; Yanagimachi, Shinya; Tanabe, Takehiko; Hagimoto, Ken; Hirano, Iku; Watabe, Ken-ichi; Ikegami, Takeshi; Hartnett, John G

    2014-09-01

    The frequency stability of an atomic fountain clock was significantly improved by employing an ultra-stable local oscillator and increasing the number of atoms detected after the Ramsey interrogation, resulting in a measured Allan deviation of 8.3 × 10(-14)τ(-1/2)). A cryogenic sapphire oscillator using an ultra-low-vibration pulse-tube cryocooler and cryostat, without the need for refilling with liquid helium, was applied as a local oscillator and a frequency reference. High atom number was achieved by the high power of the cooling laser beams and optical pumping to the Zeeman sublevel m(F) = 0 employed for a frequency measurement, although vapor-loaded optical molasses with the simple (001) configuration was used for the atomic fountain clock. The resulting stability is not limited by the Dick effect as it is when a BVA quartz oscillator is used as the local oscillator. The stability reached the quantum projection noise limit to within 11%. Using a combination of a cryocooled sapphire oscillator and techniques to enhance the atom number, the frequency stability of any atomic fountain clock, already established as primary frequency standard, may be improved without opening its vacuum chamber.

  12. FOG: Fighting the Achilles' Heel of Gossip Protocols with Fountain Codes

    Science.gov (United States)

    Champel, Mary-Luc; Kermarrec, Anne-Marie; Le Scouarnec, Nicolas

    Gossip protocols are well known to provide reliable and robust dissemination protocols in highly dynamic systems. Yet, they suffer from high redundancy in the last phase of the dissemination. In this paper, we combine fountain codes (rateless erasure-correcting codes) together with gossip protocols for a robust and fast content dissemination in large-scale dynamic systems. The use of fountain enables to eliminate the unnecessary redundancy of gossip protocols. We propose the design of FOG, which fully exploits the first exponential growth phase (where the data is disseminated exponentially fast) of gossip protocols while avoiding the need for the shrinking phase by using fountain codes. FOG voluntarily increases the number of disseminations but limits those disseminations to the exponential growth phase. In addition, FOG creates a split-graph overlay that splits the peers between encoders and forwarders. Forwarder peers become encoders as soon as they have received the whole content. In order to benefit even further and quicker from encoders, FOG biases the dissemination towards the most advanced peers to make them complete earlier.

  13. Fountain-code Aided File Transfer in Vehicular Delay Tolerant Networks

    Directory of Open Access Journals (Sweden)

    YOUSEFI, S.

    2013-11-01

    Full Text Available We propose a mechanism for facilitating file transferring in Vehicular Delay Tolerant Networks. The proposed architecture includes using Fountain coding in the application layer, UDP in the transport layer and a proposed DTN routing algorithm in the network layer. It is assumed that files are coded based on a sample of Fountain codes which does not need in-order reception of packets. As a result, there is no need of using close-loop reliable protocols such as TCP, hence suffering from their different overheads; as a result, UDP can be used in the transport layer. In the network layer, we propose a novel DTN routing algorithm based on AODV and Store-Carry and Forward policy. This algorithm (named as AODV-DTN uses a cross layer interaction between the network and the application layer. Results of extensive simulations study for highway scenarios show that the proposed architecture leads to a better performance in terms of file delivery ratio and byte throughput when compared with FOUNTAIN and classic FTP scenarios. Furthermore, the negative effect of increasing file size is mitigated in comparison to other alternatives. It is also shown that for delay tolerant and long-distanced inter-RSU communications the proposed architecture behaves sufficiently well.

  14. Usability of the Stylus Pen in Mobile Electronic Documentation

    Directory of Open Access Journals (Sweden)

    Eunil Park

    2015-11-01

    Full Text Available Stylus pens are often used with mobile information devices. However, few studies have examined the stylus’ simple movements because the technical expertise to support documentation with stylus pens has not been developed. This study examined the usability of stylus pens in authentic documentation tasks, including three main tasks (sentence, table, and paragraph making with two types of styluses (touchsmart stylus and mobile stylus and a traditional pen. The statistical results showed that participants preferred the traditional pen in all criteria. Because of inconvenient hand movements, the mobile stylus was the least preferred on every task. Mobility does not provide any advantage in using the stylus. In addition, the study also found inconvenient hand support using a stylus and different feedback between a stylus and a traditional pen.

  15. Coefficient of variation and Power Pen's parade computation

    OpenAIRE

    Sadefo Kamdem, Jules

    2011-01-01

    Under the the assumption that income y is a power function of its rank among n individuals, we approximate the coefficient of variation and gini index as functions of the power degree of the Pen's parade. Reciprocally, for a given coefficient of variation or gini index, we propose the analytic expression of the degree of the power Pen's parade; we can then compute the Pen's parade.

  16. Microfabricated Chemical Sensors for Aerospace Fire Detection Applications

    Science.gov (United States)

    Hunter, Gary W.; Neudeck, Philip G.; Fralick, Gustave; Thomas, Valarie; Makel, D.; Liu, C. C.; Ward, B.; Wu, Q. H.

    2001-01-01

    The detection of fires on-board commercial aircraft is extremely important for safety reasons. Although dependable fire detection equipment presently exists within the cabin, detection of fire within the cargo hold has been less reliable and susceptible to false alarms. A second, independent method of fire detection to complement the conventional smoke detection techniques, such as the measurement of chemical species indicative of a fire, will help reduce false alarms and improve aircraft safety. Although many chemical species are indicative of a fire, two species of particular interest are CO and CO2. This paper discusses microfabricated chemical sensor development tailored to meet the needs of fire safety applications. This development is based on progress in three types of technology: 1) Micromachining and microfabrication (Microsystem) technology to fabricate miniaturized sensors. 2) The use of nanocrystalline materials to develop sensors with improved stability combined with higher sensitivity. 3) The development of high temperature semiconductors, especially silicon carbide. The individual sensor being developed and their level of maturity will be presented.

  17. Microfabricated Chemical Gas Sensors and Sensor Arrays for Aerospace Applications

    Science.gov (United States)

    Hunter, Gary W.

    2005-01-01

    Aerospace applications require the development of chemical sensors with capabilities beyond those of commercially available sensors. In particular, factors such as minimal sensor size, weight, and power consumption are particularly important. Development areas which have potential aerospace applications include launch vehicle leak detection, engine health monitoring, and fire detection. Sensor development for these applications is based on progress in three types of technology: 1) Micromachining and microfabrication (Microsystem) technology to fabricate miniaturized sensors; 2) The use of nanocrystalline materials to develop sensors with improved stability combined with higher sensitivity; 3) The development of high temperature semiconductors, especially silicon carbide. This presentation discusses the needs of space applications as well as the point-contact sensor technology and sensor arrays being developed to address these needs. Sensors to measure hydrogen, hydrocarbons, nitrogen oxides (NO,), carbon monoxide, oxygen, and carbon dioxide are being developed as well as arrays for leak, fire, and emissions detection. Demonstrations of the technology will also be discussed. It is concluded that microfabricated sensor technology has significant potential for use in a range of aerospace applications.

  18. Flexible, Penetrating Brain Probes Enabled by Advances in Polymer Microfabrication

    Directory of Open Access Journals (Sweden)

    Ahuva Weltman

    2016-10-01

    Full Text Available The acquisition of high-fidelity, long-term neural recordings in vivo is critically important to advance neuroscience and brain–machine interfaces. For decades, rigid materials such as metal microwires and micromachined silicon shanks were used as invasive electrophysiological interfaces to neurons, providing either single or multiple electrode recording sites. Extensive research has revealed that such rigid interfaces suffer from gradual recording quality degradation, in part stemming from tissue damage and the ensuing immune response arising from mechanical mismatch between the probe and brain. The development of “soft” neural probes constructed from polymer shanks has been enabled by advancements in microfabrication; this alternative has the potential to mitigate mismatch-related side effects and thus improve the quality of recordings. This review examines soft neural probe materials and their associated microfabrication techniques, the resulting soft neural probes, and their implementation including custom implantation and electrical packaging strategies. The use of soft materials necessitates careful consideration of surgical placement, often requiring the use of additional surgical shuttles or biodegradable coatings that impart temporary stiffness. Investigation of surgical implantation mechanics and histological evidence to support the use of soft probes will be presented. The review concludes with a critical discussion of the remaining technical challenges and future outlook.

  19. Microfabricated, amperometric, enzyme-based biosensors for in vivo applications.

    Science.gov (United States)

    Weltin, Andreas; Kieninger, Jochen; Urban, Gerald A

    2016-07-01

    Miniaturized electrochemical in vivo biosensors allow the measurement of fast extracellular dynamics of neurotransmitter and energy metabolism directly in the tissue. Enzyme-based amperometric biosensing is characterized by high specificity and precision as well as high spatial and temporal resolution. Aside from glucose monitoring, many systems have been introduced mainly for application in the central nervous system in animal models. We compare the microsensor principle with other methods applied in biomedical research to show advantages and drawbacks. Electrochemical sensor systems are easily miniaturized and fabricated by microtechnology processes. We review different microfabrication approaches for in vivo sensor platforms, ranging from simple modified wires and fibres to fully microfabricated systems on silicon, ceramic or polymer substrates. The various immobilization methods for the enzyme such as chemical cross-linking and entrapment in polymer membranes are discussed. The resulting sensor performance is compared in detail. We also examine different concepts to reject interfering substances by additional membranes, aspects of instrumentation and biocompatibility. Practical considerations are elaborated, and conclusions for future developments are presented. Graphical Abstract ᅟ.

  20. A Scalable Microfabricated Ion Trap for Quantum Information Processing

    Science.gov (United States)

    Maunz, Peter; Haltli, Raymond; Hollowell, Andrew; Lobser, Daniel; Mizrahi, Jonathan; Rembetski, John; Resnick, Paul; Sterk, Jonathan D.; Stick, Daniel L.; Blain, Matthew G.

    2016-05-01

    Trapped Ion Quantum Information Processing (QIP) relies on complex microfabricated trap structures to enable scaling of the number of quantum bits. Building on previous demonstrations of surface-electrode ion traps, we have designed and characterized the Sandia high-optical-access (HOA-2) microfabricated ion trap. This trap features high optical access, high trap frequencies, low heating rates, and negligible charging of dielectric trap components. We have observed trap lifetimes of more than 100h, measured trap heating rates for ytterbium of less than 40quanta/s, and demonstrated shuttling of ions from a slotted to an above surface region and through a Y-junction. Furthermore, we summarize demonstrations of high-fidelity single and two-qubit gates realized in this trap. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. This work was supported by the Intelligence Advanced Research Projects Activity (IARPA).

  1. Jet Penetration into a Scaled Microfabricated Stirling Cycle Regenerator

    Science.gov (United States)

    Sun, Liyong; Simon, Terrence W.; Mantell, Susan; Ibrahim, Mournir; Gedeon, David; Tew, Roy

    2008-01-01

    The cooler and heater adjacent to the regenerator of a Stirling cycle engine have tubes or channels which form jets that pass into the regenerator while diffusing within the matrix. An inactive part of the matrix, beyond the cores of these jets, does not participate fully in the heat transfer between the flow of working fluid and the regenerator matrix material, weakening the regenerator s ability to exchange heat with the working fluid. The objective of the present program is to document this effect on the performance of the regenerator and to develop a model for generalizing the results. However, the small scales of actual Stirling regenerator matrices (on the order of tens of microns) make direct measurements of this effect very difficult. As a result, jet spreading within a regenerator matrix has not been characterized well and is poorly understood. Also, modeling is lacking experimental verification. To address this, a large-scale mockup of thirty times actual scale was constructed and operated under conditions that are dynamically similar to the engine operation. Jet penetration with round jets and slot jets into the microfabricated regenerator geometry are then measured by conventional means. The results are compared with those from a study of spreading of round jets within woven screen regenerator for further documentation of the comparative performance of the microfabricated regenerator geometry.

  2. Microfabrication of transparent materials using filamented femtosecond laser beams

    Science.gov (United States)

    Butkus, S.; Paipulas, D.; Gaižauskas, Eugenijus; KaškelytÄ--, D.; Sirutkaitis, V.

    2014-05-01

    Glass drilling realized with the help of femtosecond lasers attract industrial attention, however, desired tasks may require systems employing high numerical aperture (NA) focusing conditions, low repetition rate lasers and complex fast motion translation stages. Due to the sensitivity of such systems, slight instabilities in parameter values can lead to crack formations, severe fabrication rate decrement and poor quality overall results. A microfabrication system lacking the stated disadvantages was constructed and demonstrated in this report. An f-theta lens was used in combination with a galvanometric scanner, in addition, a water pumping system that enables formation of water films of variable thickness in real time on the samples. Water acts as a medium for filament formation, which in turn decreases the focal spot diameter and increases fluence and axial focal length. This article demonstrates the application of a femtosecond (280fs) laser towards rapid cutting of different transparent materials. Filament formation in water gives rise to strong ablation at the surface of the sample, moreover, the water, surrounding the ablated area, adds increased cooling and protection from cracking. The constructed microfabrication system is capable of drilling holes in thick soda-lime, hardened glasses and sapphire. The fabrication time varies depending on the diameter of the hole and spans from a few to several hundred seconds. Moreover, complex-shape fabrication was demonstrated.

  3. Instrumentation Upgrades to TITAN's Cooler Penning Trap

    Science.gov (United States)

    Lascar, Daniel; Titan Collaboration

    2016-09-01

    The use of Highly Charged Ions (HCIs) is critical to improving the precision of Penning trap mass measurements of nuclides with half-lives substantially less than 100 ms, but the process of charge breeding imparts an unacceptably high energy spread to the ion bunch sent to TITAN's precision Penning trap for mass measurement. TITAN's Cooler PEnning Trap (CPET) at TRIUMF in Vancouver, Canada was designed to cool HCIs with a plasma of simultaneously trapped electrons. CPET is currently undergoing commissioning offline at TRIUMF. In order to prepare CPET for full operation, several technical challenges associated with the use of electrons in a strong magnetic field had to be overcome. First among these was the detection of electrons outside of CPET. A novel, thin charge-collecting detector was successfully developed. Known as the mesh detector, it is charge-agnostic and can be made effectively transparent to allow for the passage of any charged particle at the user's request. The second challenge, moving CPET's electron source off the central beam axis was overcome by the creation of an electron source which would allow for electron injection into CPET and the passage of cooled ions out of CPET. CPET's 7 T solenoid generates a stray field far outside of the magnet's central bore that forced the design of a set of electron injection optics that bend, steer and focus the beam in three dimensions. Results from the successful installation of these upgrades as well as a report on future work will be discussed. This work was partially supported by NSERC, the CFI and the DFG.

  4. French Pen Pals Made Easy KS3

    CERN Document Server

    Leleu, Sinéad

    2010-01-01

    French Pen Pals Made Easy provides an easy way for pupils to communicate in French with other French speakers. It contains fill-in-the-gap letters, so even pupils just beginning to learn French can have the satisfaction of being able to communicate effectively in French. The format is ideal for non-specialist teachers as it does not require fluency and little or no preparation is required. English translations of the letters are included, as are lists of vocabulary, key grammar points and exten

  5. Microfabricated Instrumentation for Chemical Sensing in Industrial Process Control

    Energy Technology Data Exchange (ETDEWEB)

    Ramsey, J. M.

    2000-06-01

    The monitoring of chemical constituents in manufacturing processes is of economic importance to most industries. The monitoring and control of chemical constituents may be of importance for product quality control or, in the case of process effluents, of environmental concern. The most common approach now employed for chemical process control is to collect samples which are returned to a conventional chemical analysis laboratory. This project attempts to demonstrate the use of microfabricated structures, referred to as 'lab-on-a-chip' devices, that accomplish chemical measurement tasks that emulate those performed in the conventional laboratory. The devices envisioned could be used as hand portable chemical analysis instruments where samples are analyzed in the field or as emplaced sensors for continuous 'real-time' monitoring. This project focuses on the development of filtration elements and solid phase extraction elements that can be monolithically integrated onto electrophoresis and chromatographic structures pioneered in the laboratory. Successful demonstration of these additional functional elements on integrated microfabricated devices allows lab-on-a-chip technologies to address real world samples that would be encountered in process control environments. The resultant technology has a broad application to industrial environmental monitoring problems. such as monitoring municipal water supplies, waste water effluent from industrial facilities, or monitoring of run-off from agricultural activities. The technology will also be adaptable to manufacturing process control scenarios. Microfabricated devices integrating sample filtration, solid phase extraction, and chromatographic separation with solvent programming were demonstrated. Filtering of the sample was accomplished at the same inlet with an array of seven channels each 1 {micro}m deep and 18 {micro}m wide. Sample concentration and separation were performed on channels 5 {micro}m deep

  6. Penning trap for isobaric mass separation at IGISOL

    CERN Document Server

    Kolhinen, V; Hakala, J; Jokinen, A; Kopecky, S; Rinta-Antila, S; Szerypo, J; Äystö, J

    2003-01-01

    A cylindrical Penning trap has been built at the ion guide isotope separator facility IGISOL of the University of Jyvaeskylae. The main goal of the Penning trap application is to purify low-energy radioactive ion beams. The aim is to make isobarically pure beams. The technical description is presented.

  7. Penning trap for isobaric mass separation at IGISOL

    Energy Technology Data Exchange (ETDEWEB)

    Kolhinen, V.S. E-mail: veli.kolhinen@phys.jyu.fi; Eronen, T.; Hakala, J.; Jokinen, A.; Kopecky, S.; Rinta-Antila, S.; Szerypo, J.; Aeystoe, J

    2003-05-01

    A cylindrical Penning trap has been built at the ion guide isotope separator facility IGISOL of the University of Jyvaeskylae. The main goal of the Penning trap application is to purify low-energy radioactive ion beams. The aim is to make isobarically pure beams. The technical description is presented.

  8. Dosing Accuracy of Insulin Pens Versus Conventional Syringes and Vials

    NARCIS (Netherlands)

    Y.M. Luijf; J.H. Devries

    2010-01-01

    Pen injection devices have acquired a pivotal role in insulin delivery, surpassing the use of conventional insulin syringes in many parts of the world. In this review we sought to determine differences in dosing accuracy between insulin pens and conventional syringes and vials, also touching on pati

  9. Microfabricated surface trap for scalable ion-photon interfaces

    CERN Document Server

    Herskind, Peter F; Shi, Molu; Ge, Yufei; Cetina, Marko; Chuang, Isaac L

    2010-01-01

    The combination of high-finesse optical mirrors and ion traps is attractive for quantum light-matter interfaces, which represents an enabling resource for large scale quantum information processing. We report on a scalable approach to ion-photon interfaces based on a surface electrode ion trap that is microfabricated on top of a dielectric mirror, with additional losses due to fabrication as low as 80 ppm for light at 422 nm. Stable trapping of single 88 Sr+ ions is demonstrated and the functionality of the mirror is verified by light collection from, and imaging of, the ion $169 \\pm 4 \\mu$m above the mirror. Sensitivity to laser induced charging of the trap and substrate as well as anomalous heating of the ion at 15 K is evaluated and found comparable to similar traps fabricated on conventional substrates without dielectric mirror coatings.

  10. SU-8 as a Material for Microfabricated Particle Physics Detectors

    CERN Document Server

    Maoddi, Pietro; Jiguet, Sebastien; Renaud, Philippe

    2014-01-01

    Several recent detector te chnologies developed for particle physics applications are based on microfabricated structures. Dete ctors built with this approach generally exhibit the overall best performance in te rms of spatial and time resolution. Many properties of the SU-8 photoepoxy make it suitable for the manufacturing of microstructured particle detectors. This arti cle aims to review some emerging detector technologies making use of SU-8 microstructu ring, namely micropatte rn gaseous detectors and microfluidic scintillation detectors. Th e general working principle and main process steps for the fabrication of each device are reported, with a focus on the advantages brought to the device functionality by the us e of SU-8. A novel process based on multiple bonding steps for the fabrication of thin multila yer microfluidic scin tillation detectors developed by the authors is presented. Finally, a brief overview of the applications for the discussed devices is given.

  11. A Microfabricated Involute-Foil Regenerator for Stirling Engines

    Science.gov (United States)

    Tew, Roy; Ibrahim, Mounir; Danila, Daniel; Simon, Terrence; Mantell, Susan; Sun, Liyong; Gedeon, David; Kelly, Kevin; McLean, Jeffrey; Qiu, Songgang

    2007-01-01

    A segmented involute-foil regenerator has been designed, microfabricated and tested in an oscillating-flow rig with excellent results. During the Phase I effort, several approximations of parallel-plate regenerator geometry were chosen as potential candidates for a new microfabrication concept. Potential manufacturers and processes were surveyed. The selected concept consisted of stacked segmented-involute-foil disks (or annular portions of disks), originally to be microfabricated from stainless-steel via the LiGA (lithography, electroplating, and molding) process and EDM. During Phase II, re-planning of the effort led to test plans based on nickel disks, microfabricated via the LiGA process, only. A stack of nickel segmented-involute-foil disks was tested in an oscillating-flow test rig. These test results yielded a performance figure of merit (roughly the ratio of heat transfer to pressure drop) of about twice that of the 90 percent random fiber currently used in small approx.100 W Stirling space-power convertors-in the Reynolds Number range of interest (50 to 100). A Phase III effort is now underway to fabricate and test a segmented-involute-foil regenerator in a Stirling convertor. Though funding limitations prevent optimization of the Stirling engine geometry for use with this regenerator, the Sage computer code will be used to help evaluate the engine test results. Previous Sage Stirling model projections have indicated that a segmented-involute-foil regenerator is capable of improving the performance of an optimized involute-foil engine by 6 to 9 percent; it is also anticipated that such involute-foil geometries will be more reliable and easier to manufacture with tight-tolerance characteristics, than random-fiber or wire-screen regenerators. Beyond the near-term Phase III regenerator fabrication and engine testing, other goals are (1) fabrication from a material suitable for high temperature Stirling operation (up to 850 C for current engines; up to 1200 C

  12. Microfabrication of Fresnel zone plates by laser induced solid ablation

    Science.gov (United States)

    Rodrigues, Vanessa R. M.; Thomas, John; Santhosh, Chidangil; Ramachandran, Hema; Mathur, Deepak

    2016-07-01

    A novel and simple single-step method of inscribing optical elements on metal-coated transparent substrates is demonstrated. Laser induced solid ablation (LISA) demands very low laser energies (nJ), as can be amply provided by a femtosecond laser oscillator. Here, LISA is used to write Fresnel zone plates on indium and tungsten coated glass. With up to 100 zones, remarkable agreement is obtained between measured and expected values of the focal length. LISA has enabled attainment of focal spot sizes that are 38% smaller than what would be obtained using conventional lenses of the same numerical aperture. The simplicity with which a high degree of automation can readily be achieved using LISA makes this cost-effective method amenable to a wide variety of applications related to microfabrication of optical elements.

  13. How to Concentrate Genomic Length DNA in a Microfabricated Array

    Science.gov (United States)

    Chen, Yu; Abrams, Ezra; Boles, Christian; Pedersen, Jonas; Flyvbjerg, Henrik; Sturm, James; Austin, Robert

    We demonstrate that a microfabricated bump array can concentrate genomic-length DNA molecules efficiently at continuous, high flow velocities, up to 40 ?m/s, if the single-molecule DNA globule has a sufficiently large shear modulus.. Increase in the shear modulus is accomplished by compacting the DNA molecules to minimal coil-size using polyethylene glycol (PEG) derived depletion forces. We map out the sweet spot where concentration occurs as a function of PEG con- centration, flow speed, and bump array parameters using a combination of theoretical analysis and experiment. Purification of DNA from enzymatic reactions for next-generation DNA-sequencing libraries will be an important application of this development.

  14. Beautiful Style of Pen:Three Journeys of the Hero Fountain Pen Design%生花妙笔——英雄金笔设计的三个征程

    Institute of Scientific and Technical Information of China (English)

    李江; 黄德荃

    2015-01-01

    英雄钢笔曾以良好的品质树立了中国钢笔企业的标杆地位,但随着市场的改变,自来水笔行业面临巨大困境.英雄笔厂从设计层面对产品和品牌进行了一系列升级改造,让曾经的国货精品在追求个性、崇尚艺术化生活的今天焕发出新的光彩.

  15. Near-field microscopy with a microfabricated solid immersion lens

    Science.gov (United States)

    Fletcher, Daniel Alden

    2001-07-01

    Diffraction of focused light prevents optical microscopes from resolving features in air smaller than half the wavelength, λ Spatial resolution can be improved by passing light through a sub-wavelength metal aperture scanned close to a sample, but aperture-based probes suffer from low optical throughput, typically below 10-4. An alternate and more efficient technique is solid immersion microscopy in which light is focused through a high refractive index Solid Immersion Lens (SIL). This work describes the fabrication, modeling, and use of a microfabricated SIL to obtain spatial resolution better than the diffraction limit in air with high optical throughput for infrared applications. SILs on the order of 10 μm in diameter are fabricated from single-crystal silicon and integrated onto silicon cantilevers with tips for scanning. We measure a focused spot size of λ/5 with optical throughput better than 10-1 at a wavelength of λ = 9.3 μm. Spatial resolution is improved to λ/10 with metal apertures fabricated directly on the tip of the silicon SIL. Microlenses have reduced spherical aberration and better transparency than large lenses but cannot be made arbitrarily small and still focus. We model the advantages and limitations of focusing in lenses close to the wavelength in diameter using an extension of Mie theory. We also investigate a new contrast mechanism unique to microlenses resulting from the decrease in field-of-view with lens diameter. This technique is shown to achieve λ/4 spatial resolution. We explore applications of the microfabricated silicon SIL for high spatial resolution thermal microscopy and biological spectroscopy. Thermal radiation is collected through the SIL from a heated surface with spatial resolution four times better than that of a diffraction- limited infrared microscope. Using a Fourier-transform infrared spectrometer, we observe absorption peaks in bacteria cells positioned at the focus of the silicon SIL.

  16. DEVELOPMENT OF THE MAIN PROVISIONS OF SANITARY NORMS AND RULES EPIDEMIOLOGICAL SAFETY FOUNTAINS OF UKRAINE AND RUSSIA

    Directory of Open Access Journals (Sweden)

    Manuilov MB

    2013-03-01

    Full Text Available The article presents the main points of sanitary norms and rules of operation of fountains operating in recirculation mode (water recycling and their water supply from water bodies or water supply systems (flow mode, developed on the basis of standards of operation of swimming pools. Based on a proposal formulated standards specifications applicable to the disinfection system and water purification fountains operating in recirculation mode, implemented in the form of technology based on the bactericidal properties of silver ions and copper. The presented approach to biosecurity fountains found support from the Ministry of Health of Ukraine and has been the basis of input sanitary norms and regulations will come into effect in 2013.

  17. The influence of pH/conductivity of fountain solution on dot circularity, line and text raggedness

    Directory of Open Access Journals (Sweden)

    Ivana Oros

    2012-08-01

    Full Text Available The influence of pH and conductivity of fountain solutions on the quality of dot, line and text raggedness was investigated. Physico-chemical parameters of fountain solutions were analyzed by standard methods. Image quality assessment (IQA was carried out using the ISO methodology and ImageJ software. There is a great influence of pH and conductivity of fountain solutions on the final quality of magenta prints. Magenta dot circularity on the printed sheets showed the mutual nonlinear dependence, second-order polynomial, followed by equation: y = 0.00514x2 - 0.07524x + 0.78238. Line analysis pointed out the least raggedly edges of 1pt horizontal and vertical lines. Times printed text had the most raggedly edges in comparison with Arial. The results indicated that the dot circularity, line and text raggedness could be useful attributes in the quality control of offset prints.

  18. NovoPen Echo® insulin delivery device

    Directory of Open Access Journals (Sweden)

    Hyllested-Winge J

    2016-01-01

    Full Text Available Jacob Hyllested-Winge,1 Thomas Sparre,2 Line Kynemund Pedersen2 1Novo Nordisk Pharma Ltd, Tokyo, Japan; 2Novo Nordisk A/S, Søborg, Denmark Abstract: The introduction of insulin pen devices has provided easier, well-tolerated, and more convenient treatment regimens for patients with diabetes mellitus. When compared with vial and syringe regimens, insulin pens offer a greater clinical efficacy, improved quality of life, and increased dosing accuracy, particularly at low doses. The portable and discreet nature of pen devices reduces the burden on the patient, facilitates adherence, and subsequently contributes to the improvement in glycemic control. NovoPen Echo® is one of the latest members of the NovoPen® family that has been specifically designed for the pediatric population and is the first to combine half-unit increment (=0.5 U of insulin dosing with a simple memory function. The half-unit increment dosing amendments and accurate injection of 0.5 U of insulin are particularly beneficial for children (and insulin-sensitive adults/elders, who often require small insulin doses. The memory function can be used to record the time and amount of the last dose, reducing the fear of double dosing or missing a dose. The memory function also provides parents with extra confidence and security that their child is taking insulin at the correct doses and times. NovoPen Echo is a lightweight, durable insulin delivery pen; it is available in two different colors, which may help to distinguish between different types of insulin, providing more confidence for both users and caregivers. Studies have demonstrated a high level of patient satisfaction, with 80% of users preferring NovoPen Echo to other pediatric insulin pens. Keywords: NovoPen Echo®, memory function, half-unit increment dosing, adherence, children, adolescents 

  19. Polymer-Pen Chemical Lift-Off Lithography.

    Science.gov (United States)

    Xu, Xiaobin; Yang, Qing; Cheung, Kevin M; Zhao, Chuanzhen; Wattanatorn, Natcha; Belling, Jason N; Abendroth, John M; Slaughter, Liane S; Mirkin, Chad A; Andrews, Anne M; Weiss, Paul S

    2017-05-10

    We designed and fabricated large arrays of polymer pens having sub-20 nm tips to perform chemical lift-off lithography (CLL). As such, we developed a hybrid patterning strategy called polymer-pen chemical lift-off lithography (PPCLL). We demonstrated PPCLL patterning using pyramidal and v-shaped polymer-pen arrays. Associated simulations revealed a nanometer-scale quadratic relationship between contact line widths of the polymer pens and two other variables: polymer-pen base line widths and vertical compression distances. We devised a stamp support system consisting of interspersed arrays of flat-tipped polymer pens that are taller than all other sharp-tipped polymer pens. These supports partially or fully offset stamp weights thereby also serving as a leveling system. We investigated a series of v-shaped polymer pens with known height differences to control relative vertical positions of each polymer pen precisely at the sub-20 nm scale mimicking a high-precision scanning stage. In doing so, we obtained linear-array patterns of alkanethiols with sub-50 nm to sub-500 nm line widths and minimum sub-20 nm line width tunable increments. The CLL pattern line widths were in agreement with those predicted by simulations. Our results suggest that through informed design of a stamp support system and tuning of polymer-pen base widths, throughput can be increased by eliminating the need for a scanning stage system in PPCLL without sacrificing precision. To demonstrate functional microarrays patterned by PPCLL, we inserted probe DNA into PPCLL patterns and observed hybridization by complementary target sequences.

  20. High Velocity Precessing Jets from the Water Fountain IRAS 18286-0959 Revealed by VLBA Observations

    OpenAIRE

    Yung, Bosco; Nakashima, Jun-ichi; Imai, Hiroshi; Deguchi, Shuji; Diamond, Philip; Kwok, Sun

    2011-01-01

    We report the results of multi-epoch VLBA observations of the 22.2GHz water maser emission associated with the "water fountain" IRAS 18286-0959. We suggest that this object is the second example of a highly collimated bipolar precessing outflow traced by water maser emission, the other is W43A. The detected water emission peaks are distributed over a velocity range from -50km/s to 150km/s. The spatial distribution of over 70% of the identified maser features is found to be highly collimated a...

  1. Distributed cavity phase frequency shifts of the caesium fountain PTB-CSF2

    CERN Document Server

    Weyers, S; Nemitz, N; Li, R; Gibble, K

    2011-01-01

    We evaluate the frequency error from distributed cavity phase in the caesium fountain clock PTB-CSF2 at the Physikalisch-Technische Bundesanstalt with a combination of frequency measurements and ab initio calculations. The associated uncertainty is 1.3E-16, with a frequency bias of 0.4E-16. The agreement between the measurements and calculations explains the previously observed frequency shifts at elevated microwave amplitude. We also evaluate the frequency bias and uncertainty due to the microwave lensing of the atomic wavepackets. We report a total PTB-CSF2 systematic uncertainty of 4.1E-16.

  2. Volatile Organic Compound (VOC) emissions from feedlot pen surface materials as affected by within pen location, moisture, and temperature

    Science.gov (United States)

    A laboratory study was conducted to evaluate the effects of pen location, moisture, and temperature on emissions of volatile organic compounds (VOC) from surface materials obtained from feedlot pens where beef cattle were fed a diet containing 30% wet distillers grain plus solubles. Surface material...

  3. Femtolitre chemistry assisted by microfluidic pen lithography.

    Science.gov (United States)

    Carbonell, Carlos; Stylianou, Kyriakos C; Hernando, Jordi; Evangelio, Emi; Barnett, Sarah A; Nettikadan, Saju; Imaz, Inhar; Maspoch, Daniel

    2013-01-01

    Chemical reactions at ultrasmall volumes are becoming increasingly necessary to study biological processes, to synthesize homogenous nanostructures and to perform high-throughput assays and combinatorial screening. Here we show that a femtolitre reaction can be realized on a surface by handling and mixing femtolitre volumes of reagents using a microfluidic stylus. This method, named microfluidic pen lithography, allows mixing reagents in isolated femtolitre droplets that can be used as reactors to conduct independent reactions and crystallization processes. This strategy overcomes the high-throughput limitations of vesicles and micelles and obviates the usually costly step of fabricating microdevices and wells. We anticipate that this process enables performing distinct reactions (acid-base, enzymatic recognition and metal-organic framework synthesis), creating multiplexed nanoscale metal-organic framework arrays, and screening combinatorial reactions to evaluate the crystallization of novel peptide-based materials.

  4. Femtolitre chemistry assisted by microfluidic pen lithography

    Science.gov (United States)

    Carbonell, Carlos; Stylianou, Kyriakos C.; Hernando, Jordi; Evangelio, Emi; Barnett, Sarah A.; Nettikadan, Saju; Imaz, Inhar; Maspoch, Daniel

    2013-01-01

    Chemical reactions at ultrasmall volumes are becoming increasingly necessary to study biological processes, to synthesize homogenous nanostructures and to perform high-throughput assays and combinatorial screening. Here we show that a femtolitre reaction can be realized on a surface by handling and mixing femtolitre volumes of reagents using a microfluidic stylus. This method, named microfluidic pen lithography, allows mixing reagents in isolated femtolitre droplets that can be used as reactors to conduct independent reactions and crystallization processes. This strategy overcomes the high-throughput limitations of vesicles and micelles and obviates the usually costly step of fabricating microdevices and wells. We anticipate that this process enables performing distinct reactions (acid-base, enzymatic recognition and metal-organic framework synthesis), creating multiplexed nanoscale metal-organic framework arrays, and screening combinatorial reactions to evaluate the crystallization of novel peptide-based materials. PMID:23863998

  5. Response of cyanobacteria to the fountain-based water aeration system in Jeziorak Mały urban lake

    Directory of Open Access Journals (Sweden)

    Zębek Elżbieta

    2014-03-01

    Full Text Available This study of cyanobacteria phytoplankton was conducted from May to August in 2002, 2003 and 2005 during fountain-based water aeration in the pelagial of the Jeziorak Mały urban lake in Poland. Additional water mixing by this installation’s activity changed the cyanobacterial growth conditions. Although less of their proportion was noted in total phytoplankton abundance, higher mean abundance and biomass were recorded at the fountain than at the lake centre. Higher water temperature in the surface layer favoured cyanobacterial growth at the fountain, while higher iron concentration stimulated their development in the lake’s centre. This was supported by positive correlations between their abundance and these water parameters. Moreover, the fountain’s activity contributed to the cyanobacteria sinking in the water column. The higher abundance of cyanobacteria was found at 1m depth in May, July and August than in the fountain surface layer. Additional water mixing during fountain activity caused also a shift in their abundance maximum (C - June and F - August and contributed to intensive organic matter decomposition. These conditions promoted cyanobacterial nutrient uptake from the water at the fountain, and this is supported by the negative correlation between their abundance and orthophosphate and total nitrogen concentrations. Generally, water mixing during the fountain’s activity does not inhibit the growth of cyanobacteria. This phenomenon disturbed abundance dynamics of the cyanobacteria in summer months but didn’t contribute to their abundance decrease. It is important for these results to be considered in future management of shallow urban lakes.

  6. First performance results of PTB's atomic caesium fountain and a study of contributions to its frequency instability.

    Science.gov (United States)

    Weyers, S; Bauch, A; Hubner, U; Schroder, R; Tamm, C

    2000-01-01

    At the Physikalisch-Technische Bundesanstalt (PTB), an atomic caesium fountain was constructed. Ramsey fringes with a full width at half maximum (FWHM) of 0.86 Hz were obtained by launching the atoms to a height of 83 cm above the cooling region (40 cm above the microwave cavity center). A first measurement of the homogeneity of the magnetic flux density yields 0.33 nT (rms), only 0.16% of the mean value of 0.205 muT used in normal operation. The inherent elementary noise contributions of the fountain and of a thermal beam atomic clock are compared in some detail.

  7. Measurement of the magnetic field profile in the atomic fountain clock FoCS-2 using Zeeman spectroscopy

    CERN Document Server

    Laurent, Devenoges; André, Stefanov; Antoine, Jallageas; Jacques, Morel; Thomas, Südmeyer; Pierre, Thomann

    2016-01-01

    We report the evaluation of the second order Zeeman shift in the continuous atomic fountain clock FoCS-2. Because of the continuous operation and its geometrical constraints, the methods used in pulsed fountain are not applicable. We use here time-resolved Zeeman spectroscopy to probe the magnetic field profile in the clock. The pulses of ac magnetic excitation allow us to measure the Zeeman frequency with spatial resolution and to evaluate the Zeeman shift with an uncertainty smaller than 10E-16 in relative units.

  8. DETERMINATION OF HETEROGENEOUS ELECTRON TRANSFER RATE CONSTANTS AT MICROFABRICATED IRIDIUM ELECTRODES. (R825511C022)

    Science.gov (United States)

    There has been an increasing use of both solid metal and microfabricated iridium electrodes as substrates for various types of electroanalysis. However, investigations to determine heterogeneous electron transfer rate constants on iridium, especially at an electron beam evapor...

  9. DETERMINATION OF HETEROGENEOUS ELECTRON TRANSFER RATE CONSTANTS AT MICROFABRICATED IRIDIUM ELECTRODES. (R825511C022)

    Science.gov (United States)

    There has been an increasing use of both solid metal and microfabricated iridium electrodes as substrates for various types of electroanalysis. However, investigations to determine heterogeneous electron transfer rate constants on iridium, especially at an electron beam evapor...

  10. Detection of adsorbed explosive molecules using thermal response of suspended microfabricated bridges

    DEFF Research Database (Denmark)

    Yi, Dechang; Greve, Anders; Hales, Jan Harry;

    2008-01-01

    Here we present a thermophysical technique that is capable of differentiating vapor phase adsorbed explosives from nonexplosives and is additionally capable of differentiating individual species of common explosive vapors. This technique utilizes pairs of suspended microfabricated silicon bridges...

  11. Piezoelectric properties of microfabricated (K,Na)NbO3 thin films

    OpenAIRE

    Wakasa, Yu; Kanno, Isaku; Yokokawa, Ryuji; Kotera, Hidetoshi; Shibata, Kenji; Mishima, Tomoyoshi

    2011-01-01

    A novel microfabrication method of lead-free piezoelectric sodium potassium niobate [(K, Na)NbO3, KNN] thin films was proposed, and the piezoelectric characteristics of the KNN microactuators were evaluated. The KNN thin films were directly deposited on microfabricated Si microcantilevers. The transverse piezoelectric coefficient d31 of the KNN films was calculated as −53.5 pm/V at 20 Vpp from the tip displacement of the microcantilevers. However, the tip displacement showed large electric-fi...

  12. Microfabricated Cantilevers Based on Sputtered Thin-Film Ni50Ti50 Shape Memory Alloy (SMA)

    Science.gov (United States)

    2015-08-01

    Memory Alloy ( SMA ) by Cory R Knick and Christopher J Morris Approved for public release; distribution unlimited...Microfabricated Cantilevers Based on Sputtered Thin-Film Ni50Ti50 Shape Memory Alloy ( SMA ) by Cory R Knick and Christopher J Morris Sensors...2014 – 05/2015 4. TITLE AND SUBTITLE Microfabricated Cantilevers Based on Sputtered Thin-Film Ni50Ti50 Shape Memory Alloy ( SMA ) 5a. CONTRACT NUMBER

  13. Annual Parallax Distance and Secular Motion of the Water Fountain Source IRAS 18286-0959

    CERN Document Server

    Imai, Hiroshi; Honma, Mareki; Miyaji, Takeshi

    2012-01-01

    We report on results of astrometric observations of water vapor masers in the "water fountain" source IRAS 18286-0959 (I18286) with the VLBI Exploration of Radio Astrometry (VERA). These observations yielded an annual parallax of IRAS 18286-0959, pi=0.277+/-0.041 mas, corresponding to a heliocentric distance of D=3.61(+0.63)(-0.47) kpc. The maser feature, whose annual parallax was measured, showed the absolute proper motion of (mu_alpha, mu_delta)=(-3.2 +/- 0.3, -7.2 +/- 0.2) [mas/yr]. The intrinsic motion of the maser feature in the internal motions of the cluster of features in I18286 does not seem to trace the motion of the bipolar jet of I18286. Taking into account this intrinsic motion, the derived motion of the maser feature is roughly equal to that of the maser source I18286 itself. The proximity of I18286 to the Galactic midplane (z~10 pc) suggests that the parental star of the water fountain source in I18286 should be intermediate-mass AGB/post-AGB star, but the origin of a large deviation of the sys...

  14. Historical, Social and Aesthetical Discourse in the Architecture of Vilnius Fountains

    Directory of Open Access Journals (Sweden)

    Antanas Stančius

    2016-04-01

    Full Text Available This article attempts to review connections between Vilnius city culture and water, as an architectural mean. It aims to determine social and aesthetical aspects of water in development of Vilnius architecture in the context of cultural flux and changing urbanistic concepts. The main research methods are the interpretation of texts, historical reflection and analysis of cartographic material. In Vilnius architecture, water reflects functional principles and artistic conceptions of various historical periods. The usage of water as an aesthetic means was commenced in Renaissance Vilnius sculpture fountains. During the Soviet period, regardless of the heritage and historical traditions, geometrically developed city structure destroyed individual character and aesthetic charm. By absolutizing of geometric forms, modern urbanists deprived the city of life and individuality. Aesthetic value of water had been annulled and fountains were designed solely on the basis of technical and ideological considerations. In the discourse of modern Lithuanian urbanism, return to the aesthetic dimension of water is observed along with innovative management schemes and technologies, ecology and art. In the conclusion it is revealed, that throughout history, it has formed only weak link between water and cultural identity. This resulted, that water, as architectural tool for social influence, was used more by external forces, rather than for internal Lithuanian cultural purposes. In the meantime, the discourse is forming, which could result in future developments of the issue.

  15. Shrinking Galaxy Disks with Fountain-Driven Accretion from the Halo

    CERN Document Server

    Elmegreen, Bruce G; Hunter, Deidre A

    2014-01-01

    Star formation in most galaxies requires cosmic gas accretion because the gas consumption time is short compared to the Hubble time. This accretion presumably comes from a combination of infalling satellite debris, cold flows, and condensation of hot halo gas at the cool disk interface, perhaps aided by a galactic fountain. In general, the accretion will have a different specific angular momentum than the part of the disk that receives it, even if the gas comes from the nearby halo. Then the gas disk expands or shrinks over time. Here we show that condensation of halo gas at a rate proportional to the star formation rate in the fountain model will preserve an initial shape, such as an exponential, with a shrinking scale length, leaving behind a stellar disk with a slightly steeper profile of younger stars near the center. This process is slow for most galaxies, producing imperceptible radial speeds, and it may be dominated by other torques, but it could be important for Blue Compact Dwarfs, which tend to have...

  16. Extracellular plant DNA in Geneva groundwater and traditional artesian drinking water fountains.

    Science.gov (United States)

    Poté, John; Mavingui, Patrick; Navarro, Elisabeth; Rosselli, Walter; Wildi, Walter; Simonet, Pascal; Vogel, Timothy M

    2009-04-01

    DNA, as the signature of life, has been extensively studied in a wide range of environments. While DNA analysis has become central to work on natural gene exchange, forensic analyses, soil bioremediation, genetically modified organisms, exobiology, and palaeontology, fundamental questions about DNA resistance to degradation remain. This paper investigated on the presence of plant DNA in groundwater and artesian fountain (groundwater-fed) samples, which relates to the movement and persistence of DNA in the environment. The study was performed in the groundwater and in the fountains, which are considered as a traditional artesian drinking water in Geneva Champagne Basin. DNA from water samples was extracted, analysed and quantified. Plant gene sequences were detected using PCR amplification based on 18S rRNA gene primers specific for eukaryotes. Physicochemical parameters of water samples including temperature, pH, conductivity, organic matter, dissolved organic carbon (DOC) and total organic carbon (TOC) were measured throughout the study. The results revealed that important quantities of plant DNA can be found in the groundwater. PCR amplification based on 18S rDNA, cloning, RFLP analysis and sequencing demonstrated the presence of plant DNA including Vitis rupestris, Vitis berlandieri, Polygonum sp. Soltis, Boopis graminea, and Sinapis alba in the water samples. Our observations support the notion of plant DNA release, long-term persistence and movement in the unsaturated medium as well as in groundwater aquifers.

  17. Fire Fountains At Etna Volcano: What Do We Learn From Acoustic Measurements?

    Science.gov (United States)

    Vergniolle, S.

    Acoustic measurements were performed on Etna volcano (Italy) in July 2001, during two episodes of quasi fire fountains. They last about 4 h, are separated by quiet peri- ods of a few days and consist in a serie of explosions, whose intermittency increases in time from several minutes to several seconds. The waveform of every explosion is very similar to explosions at Stromboli, suggesting that the sound at Etna is also pro- duced by bursting large bubbles. The model for bubble vibration, at work at Stromboli, gives a very good fit between data and theory. When the eruptive episode reaches its climax, a bubble at Etna has a radius of 5 m, a length of 8 m for an overpressure of 0.39 MPa. Rising large expanding bubbles in a conduit distorts the top of the lava column and sloshing waves can be produced. The theoretical frequency is between 0.3 and 0.7 Hz for a radius of 5 m. Recorded acoustic pressure shows these frequen- cies. Their intensity is directly correlated to the intensity for bubble bursting (2 Hz), showing that frequencies between 0.3 Hz and 0.7 Hz are sloshing waves in a conduit radius of 5 m. Furthermore if the source of sound is monopole, gas and ejecta ve- locity is estimated at 92 m/s during episode climax, assuming a conduit radius of 5 m. Simultaneous measurements done with a radar produce exactly the same estimate [Duboclard et al., 2001]. The very good agreement between the synthetic waveform, the theoretical sloshing waves and the estimate of gas velocity shows that fire foun- tains at Etna correspond to a serie of bursting bubbles of radius 5 m, colliding during its climax to form an inner gas jet. The alternance between fire fountains and quiet periods is totally similar between Etna and Kilauea volcanoes (Hawaii). Therefore fire fountains at Etna might also be generated at depth by coalescence of a foam layer trapped at the top of the magma chamber. The total gas volume released by one fire fountain is equal to 7.4 × 106 m3 and has been

  18. Microfabricated structures and devices featuring nanostructured titania thin films

    Science.gov (United States)

    Monkowski, Adam J.

    2007-05-01

    When titanium reacts with hydrogen peroxide at 80°C--100°C, a nanostructured titania (NST) thin film is formed on the titanium surface. This nanostructured film is particularly suited for integration with thin film and bulk microfabrication techniques. The ability to manufacture devices in a batch format is a principal advantage of microfabrication-based production. To reliably produce arrays of micro-patterned NST thin films on the wafer scale, a patterning guideline must be considered. The formation of NST relies on a re-deposition process; adequate ti-peroxo species must be generated and remain at the solid-solution interface. Numerical analysis of the characteristic transient diffusion behavior for various micro-patterns has been compared with experimental data to generate a criterion to guide the design of NST micro-patterns. Wafer scale arrays of NST micro gas-sensors have been fabricated using standard thin film techniques. Sensing elements are 20 mum on a side. High sensitivity to hydrogen is achieved by modification of the sensors with platinum nanoparticles. When exposed to a 10 mT partial pressure of hydrogen at 250°C, the functionalized devices exhibit more than one order of magnitude resistance decrease with a response time of approximately 7 sec. Titanium microstructures formed using the titanium ICP deep etch (TIDE) process have been integrated with NST films to produce an ordered nanostructure-microstructure composite (3D-NST). The process developed allows for the incorporation of a planar top surface, advantageous for bonding and sealing applications, in which the nanostructured thin film is formed only on feature sidewalls and floors. When titanium microstructures are spaced less than 1 mum apart, titania nanostructures bridge adjacent features. NST and 3D-NST structures have been assembled and tested in a dye-sensitized solar cell (DSSC) device. The NST film is approximately 900nm thick; this yielded a DSSC with an efficiency of 1.8%, similar

  19. Three-dimensional microfabrication using two-photon polymerization

    Science.gov (United States)

    Cumpston, Brian H.; Ehrlich, Jeffrey E.; Kuebler, Stephen M.; Lipson, Matthew; Marder, Seth R.; McCord-Maughon, D.; Perry, Joseph W.; Roeckel, Harold; Rumi, Maria Cristina

    1998-09-01

    Photopolymerization initiated by the simultaneous absorption of two photons is unique in its ability to produce complex three-dimensional (3D) structures from a single, thick photopolymer film. Strong 3D confinement of the polymerization process is not possible in other polymer microfabrication techniques such as LIGA, rapid prototyping, and conventional photoresist technology. Two-photon polymerization also permits the fabrication of 3D structures and the definition of lithographic features on non-planar surfaces. We have developed a wide array of chromophores which hold great promise for 3D microfabrication, as well as other applications, such as two-photon fluorescence imaging and 3D optical data storage. These materials are based on a donor- (pi) -donor, donor-acceptor-donor, or acceptor-donor-acceptor structural motif. The magnitude of the two-photon absorption cross-section, (delta) , and the position of the two-photon absorption maximum, (lambda) (2)max, can be controlled by varying the length of the conjugated bridge and by varying the strength of the donor/acceptor groups. In this way, chromophores have been developed which exhibit strong two- photon absorption in the range of 500 - 975 nm, in some cases as high as 4400 X 10-50 cm4 s/photon-molecule. In the case of donor-(pi) -donor structures, quantum-chemical calculations show that the large absorption cross-sections arise from the symmetric re-distribution of charge from the donor end-groups to the conjugated bridge, resulting in an electronic excited-state which is more delocalized than the ground state. For many of these molecules, two-photon excitation populates a state which is sufficiently reducing that a charge transfer reaction can occur with acrylate monomers. The efficiency of these processes can be described using Marcus theory. Under suitable conditions, such reactions can induce radical polymerization of acrylate resins. Polymerization rates have been measured, and we show that these two

  20. Angels with Nanotech Wings: Magic, Medicine and Technology in Aronofksky's The Fountain, Gibson's The Neuromancer and Slonczewski's Brain Plague

    NARCIS (Netherlands)

    Lord, C.M.

    2009-01-01

    Darren Aronofsky's feature film The Fountain (2006), William Gibson's celebrated novel The Neuromancer (1984)and Joan Slonczewski'ls best-seller Brain Plague (2000), all have in common a preoccupation with the neuroscientific secrets of the brain. But more than this, all these works that explore the

  1. Angels with Nanotech Wings: Magic, Medicine and Technology in Aronofksky's The Fountain, Gibson's The Neuromancer and Slonczewski's Brain Plague

    NARCIS (Netherlands)

    Lord, C.M.

    2009-01-01

    Darren Aronofsky's feature film The Fountain (2006), William Gibson's celebrated novel The Neuromancer (1984)and Joan Slonczewski'ls best-seller Brain Plague (2000), all have in common a preoccupation with the neuroscientific secrets of the brain. But more than this, all these works that explore the

  2. Microfabricated Hydrogen Sensor Technology for Aerospace and Commercial Applications

    Science.gov (United States)

    Hunter, Gary W.; Bickford, R. L.; Jansa, E. D.; Makel, D. B.; Liu, C. C.; Wu, Q. H.; Powers, W. T.

    1994-01-01

    Leaks on the Space Shuttle while on the Launch Pad have generated interest in hydrogen leak monitoring technology. An effective leak monitoring system requires reliable hydrogen sensors, hardware, and software to monitor the sensors. The system should process the sensor outputs and provide real-time leak monitoring information to the operator. This paper discusses the progress in developing such a complete leak monitoring system. Advanced microfabricated hydrogen sensors are being fabricated at Case Western Reserve University (CWRU) and tested at NASA Lewis Research Center (LeRC) and Gencorp Aerojet (Aerojet). Changes in the hydrogen concentrations are detected using a PdAg on silicon Schottky diode structure. Sensor temperature control is achieved with a temperature sensor and heater fabricated onto the sensor chip. Results of the characterization of these sensors are presented. These sensors can detect low concentrations of hydrogen in inert environments with high sensitivity and quick response time. Aerojet is developing the hardware and software for a multipoint leak monitoring system designed to provide leak source and magnitude information in real time. The monitoring system processes data from the hydrogen sensors and presents the operator with a visual indication of the leak location and magnitude. Work has commenced on integrating the NASA LeRC-CWRU hydrogen sensors with the Aerojet designed monitoring system. Although the leak monitoring system was designed for hydrogen propulsion systems, the possible applications of this monitoring system are wide ranged. Possible commercialization of the system will also be discussed.

  3. Microfabricated microbial fuel cell arrays reveal electrochemically active microbes.

    Directory of Open Access Journals (Sweden)

    Huijie Hou

    Full Text Available Microbial fuel cells (MFCs are remarkable "green energy" devices that exploit microbes to generate electricity from organic compounds. MFC devices currently being used and studied do not generate sufficient power to support widespread and cost-effective applications. Hence, research has focused on strategies to enhance the power output of the MFC devices, including exploring more electrochemically active microbes to expand the few already known electricigen families. However, most of the MFC devices are not compatible with high throughput screening for finding microbes with higher electricity generation capabilities. Here, we describe the development of a microfabricated MFC array, a compact and user-friendly platform for the identification and characterization of electrochemically active microbes. The MFC array consists of 24 integrated anode and cathode chambers, which function as 24 independent miniature MFCs and support direct and parallel comparisons of microbial electrochemical activities. The electricity generation profiles of spatially distinct MFC chambers on the array loaded with Shewanella oneidensis MR-1 differed by less than 8%. A screen of environmental microbes using the array identified an isolate that was related to Shewanella putrefaciens IR-1 and Shewanella sp. MR-7, and displayed 2.3-fold higher power output than the S. oneidensis MR-1 reference strain. Therefore, the utility of the MFC array was demonstrated.

  4. Integration of micro-fabricated atomic magnetometers on military systems

    Science.gov (United States)

    Schultz, Gregory; Mhaskar, Rahul; Prouty, Mark; Miller, Jonathan

    2016-05-01

    A new generation of ultra-high sensitivity magnetic sensors based on innovative micro-electromechanical systems (MEMS) are being developed and incorporated into military systems. Specifically, we are currently working to fully integrate the latest generation of MicroFabricated Atomic Magnetometers (MFAMs) developed by Geometrics on defense mobility systems such as unmanned systems, military vehicles and handheld units. Recent reductions in size, weight, and power of these sensors has enabled new deployment opportunities for improved sensitivity to targets of interest, but has also introduced new challenges associated with noise mitigation, mission configuration planning, and data processing. Our work is focused on overcoming the practical aspects of integrating these sensors with various military platforms. Implications associated with utilizing these combined sensor systems in working environments are addressed in order to optimize signal-to-noise ratios, detection probabilities, and false alarm mitigation. Specifically, we present collaborative work that bridges the gap between commercial specialists and operation platform integration organizations including magnetic signature characterization and mitigation as well as the development of simulation tools that consider a wide array of sensor, environmental, platform, and mission-level parameters. We discuss unique deployment concepts for explosive hazard target geolocation, and data processing. Applications include configurations for undersea and underground threat detection - particularly those associated with stationary or mobile explosives and compact metallic targets such as munitions, subsea threats, and other hazardous objects. We show the potential of current and future features of miniaturized magnetic sensors including very high magnetic field sensitivities, bandwidth selectivity, and array processing.

  5. Microfabricated Thin Film Impedance Sensor & AC Impedance Measurements

    Directory of Open Access Journals (Sweden)

    Jinsong Yu

    2010-06-01

    Full Text Available Thin film microfabrication technique was employed to fabricate a platinum based parallel-electrode structured impedance sensor. Electrochemical impedance spectroscopy (EIS and equivalent circuit analysis of the small amplitude (±5 mV AC impedance measurements (frequency range: 1 MHz to 0.1 Hz at ambient temperature were carried out. Testing media include 0.001 M, 0.01 M, 0.1 M NaCl and KCl solutions, and alumina (~3 μm and sand (~300 μm particulate layers saturated with NaCl solutions with the thicknesses ranging from 0.6 mm to 8 mm in a testing cell, and the results were used to assess the effect of the thickness of the particulate layer on the conductivity of the testing solution. The calculated resistances were approximately around 20 MΩ, 4 MΩ, and 0.5 MΩ for 0.001 M, 0.01 M, and 0.1 M NaCl solutions, respectively. The presence of the sand particulates increased the impedance dramatically (6 times and 3 times for 0.001 M and 0.1 M NaCl solutions, respectively. A cell constant methodology was also developed to assess the measurement of the bulk conductivity of the electrolyte solution. The cell constant ranged from 1.2 to 0.8 and it decreased with the increase of the solution thickness.

  6. Microfabricated planar glass gas chromatography with photoionization detection.

    Science.gov (United States)

    Lewis, Alastair C; Hamilton, Jacqueline F; Rhodes, Christopher N; Halliday, Jaydene; Bartle, Keith D; Homewood, Philip; Grenfell, Robin J P; Goody, Brian; Harling, Alice M; Brewer, Paul; Vargha, Gergely; Milton, Martin J T

    2010-01-29

    We report the development of a microfabricated gas chromatography system suitable for the separation of volatile organic compounds (VOCs) and compatible with use as a portable measurement device. Hydrofluoric acid etching of 95x95mm Schott B270 wafers has been used to give symmetrical hemi-spherical channels within a glass substrate. Two matching glass plates were subsequently cold bonded with the channels aligned; the flatness of the glass surfaces resulted in strong bonding through van der Waals forces. The device comprised gas fluidic interconnections, injection zone and 7.5 and 1.4m long, 320microm internal diameter capillaries. Optical microscopy confirmed the capillaries to have fully circular channel profiles. Direct column heating and cooling could be achieved using a combination of resistive heaters and Peltier devices. The low thermal conductivity of glass allowed for multiple uniform temperature zones to be achieved within a single glass chip. Temperature control over the range 10-200 degrees C was achieved with peak power demand of approximately 25W. The 7.5m capillary column was static coated with a 2microm film of non-polar dimethylpolysiloxane stationary phase. A standard FID and a modified lightweight 100mW photoionization detector (PID) were coupled to the column and performance tested with gas mixtures of monoaromatic and monoterpene species at the parts per million concentration level. The low power GC-PID device showed good performance for a small set of VOCs and sub ng detection sensitivity to monoaromatics.

  7. Magnetoencephalography of epilepsy with a microfabricated atomic magnetrode.

    Science.gov (United States)

    Alem, Orang; Benison, Alex M; Barth, Daniel S; Kitching, John; Knappe, Svenja

    2014-10-22

    Magnetoencephalography has long held the promise of providing a noninvasive tool for localizing epileptic seizures in humans because of its high spatial resolution compared with the scalp EEG. Yet, this promise has been elusive, not because of a lack of sensitivity or spatial resolution but because the large size and immobility of present cryogenic (superconducting) technology prevent long-term telemetry required to capture these very infrequent epileptiform events. To circumvent this limitation, we used Micro-Electro-Mechanical Systems technology to construct a noncryogenic (room temperature) microfabricated atomic magnetometer ("magnetrode") based on laser spectroscopy of rubidium vapor and similar in size and flexibility to scalp EEG electrodes. We tested the magnetrode by measuring the magnetic signature of epileptiform discharges in a rat model of epilepsy. We were able to measure neuronal currents of single epileptic discharges and more subtle spontaneous brain activity with a high signal-to-noise ratio approaching that of present superconducting sensors. These measurements are a promising step toward the goal of high-resolution noninvasive telemetry of epileptic events in humans with seizure disorders.

  8. Microfabricated silicon gas chromatographic micro-channels: fabrication and performance

    Energy Technology Data Exchange (ETDEWEB)

    Matzke, C.M.; Kottenstette, R.J.; Casalnuovo, S.A.; Frye-Mason, G.C.; Hudson, M.L.; Sasaki, D.Y.; Manginell, R.P.; Wong, C.C.

    1998-11-01

    Using both wet and plasma etching, we have fabricated micro-channels in silicon substrates suitable for use as gas chromatography (GC) columns. Micro-channel dimensions range from 10 to 80 {micro}m wide, 200 to 400 {micro}m deep, and 10 cm to 100 cm long. Micro-channels 100 cm long take up as little as 1 cm{sup 2} on the substrate when fabricated with a high aspect ratio silicon etch (HARSE) process. Channels are sealed by anodically bonding Pyrex lids to the Si substrates. We have studied micro-channel flow characteristics to establish model parameters for system optimization. We have also coated these micro-channels with stationary phases and demonstrated GC separations. We believe separation performance can be improved by increasing stationary phase coating uniformity through micro-channel surface treatment prior to stationary phase deposition. To this end, we have developed microfabrication techniques to etch through silicon wafers using the HARSE process. Etching completely through the Si substrate facilitates the treatment and characterization of the micro- channel sidewalls, which domminate the GC physico-chemical interaction. With this approach, we separately treat the Pyrex lid surfaces that form the top and bottom surfaces of the GC flow channel.

  9. Microfabrication and characterization of porous channels for DNA purification

    Science.gov (United States)

    Chen, Xing; Cui, Da-Fu; Liu, Chang-Chun; Li, Hui

    2007-01-01

    The present work demonstrates the availability of using porous channels of microfluidic chips as a solid phase matrix for extracting DNA from whole blood. Two kinds of porous channels were microfabricated by MEMS technology and anodization technology. The anodization process of porous channels was investigated and optimized. Porous channels were characterized, and a porous rectangle channel showed a more uniform and stable feature related to a porous V-type channel. The optimal porous rectangle channel was further used for purifying DNA, which showed a higher DNA recovery than the non-porous one. Optimization of the DNA elution condition established a higher DNA extracted efficiency at 55 °C than at 25 °C or at 70 °C. The time consumed in the incubation process for eluting DNA could be reduced by increasing the flow rate of the washing step. Compared to commercial kits, the porous rectangle channel under optimal conditions could extract two-fold amounts of PCR-amplifiable DNA from whole blood in 15 min. This highly efficient, effortless and flexible technology can be used as a lab-on-a-chip component for initial biologic sample preparation.

  10. Optimization of nanofountain probe microfabrication enables large-scale nanopatterning

    Science.gov (United States)

    Safi, Asmahan; Kang, Wonmo; Czapleski, David; Divan, Ralu; Moldovan, Nicolae; Espinosa, Horacio D.

    2013-12-01

    A technological gap in nanomanufacturing has prevented the translation of many nanomaterial discoveries into real-world commercialized products. Bridging this gap requires a paradigm shift in methods for fabricating nanoscale devices in a reliable and repeatable fashion. Here we present the optimized fabrication of a robust and scalable nanoscale delivery platform, the nanofountain probe (NFP), for parallel direct-write of functional materials. Microfabrication of a new generation of NFP was realized with the aim of increasing the uniformity of the device structure. Optimized probe geometry was integrated into the design and fabrication process by modifying the precursor mask dimensions and by using an isotropic selective dry etching of the outer shell that defines the protrusion area. Probes with well-conserved sharp tips and controlled protrusion lengths were obtained. Sealing effectiveness of the channels was optimized. A conformal tetraethyl orthosilicate based oxide layer increased the sealing efficacy while minimizing the required thickness. A compensation scheme based on the residual stresses in each layer was implemented to minimize bending of the cantilever after releasing the device. The device was tested by patterning ferritin catalyst arrays on silicon dioxide with sub-100 nm resolution. The optimized probes increased the control over the parallel patterning resolution which enables manufacturing of ordered arrays of nanomaterials.

  11. Microfabricated hydrogen sensor technology for aerospace and commercial applications

    Science.gov (United States)

    Hunter, Gary W.; Bickford, Randall L.; Jansa, E. D.; Makel, Darby B.; Liu, Chung-Chiun; Wu, Q. H.; Powers, William T.

    1994-10-01

    Leaks on the Space Shuttle while on the Launch Pad have generated interest in hydrogen leak monitoring technology. An effective leak monitoring system requires reliable hydrogen sensors, hardware, and software to monitor the sensors. The system should process the sensor outputs and provide real-time leak monitoring information to the operator. This paper discusses the progress in developing such a complete leak monitoring system. Advanced microfabricated hydrogen sensors are being fabricated at Case Western Reserve University (CWRU) and tested at NASA Lewis Research Center (LeRC) and Gencorp Aerojet (Aerojet). Changes in the hydrogen concentrations are detected using a PdAg on silicon Schottky diode structure. Sensor temperature control is achieved with a temperature sensor and heater fabricated onto the sensor chip. Results of the characterization of these sensors are presented. These sensors can detect low concentrations of hydrogen in inert environments with high sensitivity and quick response time. Aerojet is developing the hardware and software for a multipoint leak monitoring system designed to provide leak source and magnitude information in real time. The monitoring system processes data from the hydrogen sensors and presents the operator with a visual indication of the leak location and magnitude. Work has commenced on integrating the NASA LeRC-CWRU hydrogen sensors with the Aerojet designed monitoring system. Although the leak monitoring system was designed for hydrogen propulsion systems, the possible applications of this monitoring system are wide ranged. Possible commercialization of the system will also be discussed.

  12. A microfabricated nanocalorimeter: design, characterization, and chemical calibration.

    Science.gov (United States)

    Xu, Junkai; Reiserer, Ron; Tellinghuisen, Joel; Wikswo, John P; Baudenbacher, Franz J

    2008-04-15

    A microfabricated titration calorimeter having nanowatt sensitivity is presented. The device is achieved by modifying a commercial, suspended-membrane, thin-film thermopile infrared sensor. Chemical reactions are studied by placing a 50.0 nL droplet of one reagent directly on the sensor and injecting nanoliter droplets of a second reagent through a micropipette by means of a pressure-driven droplet injector with 1% reliability in volume delivery. External thermal noise is minimized by a two-layer thermal shielding system. Evaporation is prevented by positioning the micropipette through a tiny hole in a cover glass, sealed by a drop of oil. The device is calibrated using two acid-base reactions: H2SO4 + HEPES buffer, and NaOH + HCl. The measured power sensitivity is 2.90(4) V/W, giving a detection limit of 22 nW. The 1/e time constant for a single injection is 1.1 s. The day-to-day power sensitivity is reproducible to approximately 2%. A computational model of the sensor reproduces the power sensitivity within 10% and the time constant within 20%. For a 50 nL sample and 0.8-1.5 nL titrant injection volumes, the heat uncertainty of 44 nJ corresponds to a 3sigma detection limit of 132 nJ, or the binding energy associated with 2.9 pM of IgG-protein A complex.

  13. Microresonator Brillouin Laser Stabilization Using a Microfabricated Rubidium Cell

    CERN Document Server

    Loh, William; Leopardi, Holly F; Fortier, Tara M; Quinlan, Frank; Kitching, John; Papp, Scott B; Diddams, Scott A

    2016-01-01

    We frequency stabilize the output of a miniature stimulated Brillouin scattering (SBS) laser to rubidium atoms in a microfabricated cell to realize a laser system with frequency stability at the $10^{-11}$ level over seven decades in averaging time. In addition, our system has the advantages of robustness, low cost and the potential for integration that would lead to still further miniaturization. The SBS laser operating at 1560 nm exhibits a spectral linewidth of 820 Hz, but its frequency drifts over a few MHz on the 1 hour timescale. By locking the second harmonic of the SBS laser to the Rb reference, we reduce this drift by a factor of $10^3$ to the level of a few kHz over the course of an hour. For our combined SBS and Rb laser system, we measure a frequency noise of $4\\times10^4$ $Hz^2/Hz$ at 10 Hz offset frequency which rapidly rolls off to a level of 0.2 $Hz^2/Hz$ at 100 kHz offset. The corresponding Allan deviation is $\\leq2\\times10^{-11}$ for averaging times spanning $10^{-4}$ to $10^3$ s. By optical...

  14. Doctor--how do I use my EpiPen?

    Science.gov (United States)

    Mehr, Sam; Robinson, Marnie; Tang, Mimi

    2007-08-01

    Parents and children who have been prescribed an Epipen are often unable to demonstrate its correct administration. One contributory factor may be that doctors are unfamiliar with the EpiPen and are unable to demonstrate the correct administration of the pen to the family. The aim of this study was to determine the rate of correct EpiPen demonstration by junior and Senior Medical Staff at a major tertiary paediatric Hospital. Junior and Senior medical staff were scored on their ability to correctly use the EpiPen trainer. A 6 step scoring system was used. One-hundred doctors were recruited (Residents n = 31, Senior Residents n = 39, Fellow/Consultants n = 30). Junior and Senior Medical staff had similar scores for EpiPen demonstration, the number that needed to read the EpiPen instructions prior to use and the frequancy of accidental self-injection into the thumb. Only two doctors (2%) demonstrated all 6 administration steps correctly. The most frequent errors made were not holding the pen in place for >5 seconds (57%), failure to apply pressure to activate (21%), and self-injection into the thumb (16%). Ninety five doctors needed to read the instructions, and of these, only 39 (41%) then proceeded to correctly demonstrate the remaining 5 steps. Forty-five doctors had previously dispensed an EpiPen, but only three demonstrated its use to parents/children with a trainer. The majority of doctors do not know how to use an Epipen and are unable to provide appropriate education to parents/children. In 37% of cases, the demonstration would not have delivered adrenaline to a patient.

  15. Temporal change in biological community structure in the Fountain Creek basin, Colorado, 2001-2008

    Science.gov (United States)

    Zuellig, Robert E.; Bruce, James F.; Stogner, Robert W.

    2010-01-01

    In 2001, the U.S. Geological Survey, in cooperation with Colorado Springs City Engineering, began a study to better understand the relations between environmental characteristics and biological communities in the Fountain Creek basin in order to aide water-resource management and guide future monitoring activities. To accomplish this task, environmental (streamflow, habitat, and water chemistry) and biological (fish and macroinvertebrate) data were collected annually at 24 sites over a 6- or 8-year period (fish, 2003 to 2008; macroinvertebrates, 2001 to 2008). For this report, these data were first analyzed to determine the presence of temporal change in macroinvertebrate and fish community structure among years using nonparametric multivariate statistics. Where temporal change in the biological communities was found, these data were further analyzed using additional nonparametric multivariate techniques to determine which subset of selected streamflow, habitat, or water-chemistry variables best described site-specific changes in community structure relative to a gradient of urbanization. This study identified significant directional patterns of temporal change in macroinvertebrate and fish community structure at 15 of 24 sites in the Fountain Creek basin. At four of these sites, changes in environmental variables were significantly correlated with the concurrent temporal change identified in macroinvertebrate and fish community structure (Monument Creek above Woodmen Road at Colorado Springs, Colo.; Monument Creek at Bijou Street at Colorado Springs, Colo.; Bear Creek near Colorado Springs, Colo.; Fountain Creek at Security, Colo.). Combinations of environmental variables describing directional temporal change in the biota appeared to be site specific as no single variable dominated the results; however, substrate composition variables (percent substrate composition composed of sand, gravel, or cobble) collectively were present in 80 percent of the environmental

  16. Reticulite‐producing fountains from ring fractures in Kīlauea Caldera ca. 1500 CE: Chapter 16

    Science.gov (United States)

    May, Michael; Carey, Rebecca J.; Swanson, Don; Houghton, Bruce F.; Carey, Rebecca; Cayol, Valérie; Poland, Michael P.; Weis, Dominique

    2015-01-01

    A widely dispersed reticulite bed occurs close to the base of the Keanakākoʻi Tephra at Kīlauea Volcano. It can be divided into six subunits in the northern sector of the volcano; the reticulite also occurs in the southern sector, but outcrops are sparse owing to penecontemporaneous erosion and burial. Multilobate isopachs for each subunit and the total deposit suggest that multiple fountaining vents were distributed in the northern half of the caldera, possibly along ring fractures for the newly formed caldera. Isopach maps also show a sharp decline in thickness along the dispersal axis of each lobe, which could be explained by remobilization of tephra and/or inclined fountains. Despite such isopach characteristics, thinning rates calculated from the isopach data indicate that the fountains were among the most intense and powerful of all studied Kīlauea fountains. Density analyses of the pyroclasts suggest that fountaining was high (>600m) yet complex, possibly due to lava ponding and reentrainment. The calculated volume of the reticulite deposited around the caldera rim is approximately 0.2km3, more voluminous than the deposits of the 1959 Kīlauea Iki eruption; this volume is a minimum, however, as the low-density tephra is easily remobilized, and 600m high caldera walls probably trapped tephra within the caldera, which is deeply buried today and not accounted for in the volume calculations. The duration of this eruption was most likely at least a few days to weeks, based on the calculated volume and estimated discharge rates as seen during the Kīlauea Iki 1959 eruption.

  17. Poly-anion production in Penning and RFQ ion traps

    Energy Technology Data Exchange (ETDEWEB)

    Bandelow, Steffi; Martinez, Franklin; Marx, Gerrit; Schweikhard, Lutz [Institute for Physics, Ernst-Moritz-Arndt University, 17487 Greifswald (Germany)

    2014-07-01

    The poly-anion production is being investigated in Penning and linear radio-frequency quadrupole (RFQ) traps at the ClusterTrap setup. The range of anionic charge states produced with the electron-bath technique in a Penning trap is restricted by the upper mass limit of this trap. By installation of a cylindrical Penning trap with a 12-Tesla superconducting magnet, the mass and thus cluster-size range is enhanced by a factor of 20 compared to the previously used hyperbolic 5-Tesla Penning trap. For first experimental tests with the 12-Tesla cylindrical Penning trap, gold cluster mono-anions Au{sup n-1}, n=330-350, have been exposed to an electron bath. As a result, higher negative charge states up to hexa-anionic clusters have been observed for the first time. In a parallel effort, di- and tri-anionic gold clusters have been produced in an RFQ-trap. To this end, an electron beam is guided through the RFQ-trap, which is operated by 2- or 3-state digital driving voltages. In addition, both polyanion-production techniques have been combined by pre-charging clusters in the RFQ-trap, transferring the resulting dianions into the Penning trap and applying the electron-bath technique to produce higher charge states.

  18. Analysis of roller pen inks by capillary zone electrophoresis

    Institute of Scientific and Technical Information of China (English)

    ZHAO Pengcheng; WANG Yanji; XU Yuanyuan; YAO Lijuan

    2007-01-01

    The analysis of roller pen inks has become more and more important in fraudulent document examination because of the extensive use of roller pens in financial documents.Capillary electrophoresis with powerful resolution was applied for the analysis of roller pen inks.The experiment focused on the optimization of the separation of the extract from commercially available roller pen entries.A better separation electropherogram was obtained when a 20 mM borate buffer at pH 8.5 and a fused silica capillary with an inner diameter of 100 μm with a total length of 47 (40 cm to the detector window)were used.Five inks from roller pens of different manufacturers and countries were analyzed,and their electropherograms showed that most patterns are distinctly different from each other.Capillary with inner diameter of 100 μm increased the intensity of determination;therefore,color dyes were identified in the visible range and were able to provide more information for comparing types of roller pen inks.

  19. The effects of zonation of the pen and grouping in intact litters on use of pen, immune competence and health of pigs

    DEFF Research Database (Denmark)

    Damgaard, B.M.; Studnitz, M.; Nielsen, Jens

    2006-01-01

    The effects of pen design and group composition were examined with respect to activity, use of pen, floor conditions, health condition and immune competence for groups of 60 pigs. The experiment was designed with the two factors with zones/without zones and divided litters/intact litters....... The experiment included a total of 1440 pigs from weaning at the age of 4 weeks to the age of 18 weeks after weaning. In pens with zones, the selection of different areas for different activities was improved. Pens with zones were more dirty in the elimination and open areas than pens without zones. In pens...... to divided litters. The health condition of the pigs was unaffected by pen design, but noninfectious health condition was improved in pens with zones....

  20. Atomic fountain of laser-cooled Yb atoms for precision measurements

    CERN Document Server

    Pandey, Kanhaiya; Singh, Alok K; Natarajan, Vasant

    2010-01-01

    We demonstrate launching of laser-cooled Yb atoms in a cold atomic fountain. Atoms in a collimated thermal beam are first cooled and captured in a magneto-optic trap (MOT) operating on the strongly-allowed ${^1S}_0 \\rightarrow {^1P}_1$ transition at 399~nm (blue line). They are then transferred to a MOT on the weakly-allowed ${^1S}_0 \\rightarrow {^3P}_1$ transition at 556~nm (green line). Cold atoms from the green MOT are launched against gravity at a velocity of around 2.5~m/s using a pair of green beams. We trap more than $10^7$ atoms in the blue MOT and transfer up to 70\\% into the green MOT. The temperature for the odd isotope, $^{171}$Yb, is $\\sim$1~mK in the blue MOT, and reduces by a factor of 40 in the green MOT.

  1. Effect of turbulent fluctuations on the behaviour of fountains in stratified environments

    Science.gov (United States)

    Freire, D.; Cabeza, C.; Pauletti, S.; Sarasúa, G.; Bove, I.; Usera, G.; Martí, A. C.

    2010-09-01

    The interaction between a turbulent fountain and its stratified environment was studied. A heavy fluid, cold water, was injected vertically upwards into a linearly stratified medium. The round heavy-fluid jet reaches a maximum height before it begins to fall due to the effect of gravity. Because of the effects of friction and mixing, the vertical momentum and density of the jet fluid decrease as it submerges to an intermediate height of zero buoyancy. At this point, the jet fluid spreads as a horizontal front, intruding into the stratified environment. The degree of fluctuation in the proximity of the injection point was studied under both unrestricted- and restricted-flow configurations at the injection, using two differently sized stainless-steel woven-wire screens at the injection port as flow-restricting means. Using visualization and velocimetry techniques, both maximum and spreading heights were found to decrease with increasing turbulence at the point of injection.

  2. Art fighting its way back to aesthetics: Revisiting Marcel Duchamp’s Fountain

    Directory of Open Access Journals (Sweden)

    Anne Sejten

    2016-12-01

    Full Text Available When Claire Farago and Donald Preziosi claim that ‘art is not what you think it is,’ aesthetics itself is implicitly challenged, especially aesthetics’ seemingly inherent correlation with art. However, aesthetics, as complex and ambiguous as the concept of art, calls for a similar suspicion. In this essay, ‘Aesthetics is not what you think it is’ is thus an invitation to break through at the very point in which contemporary art seems to state the opposite—that art no longer should be a concern of aesthetics. The iconic example of Marcel Duchamp’s readymade, Fountain, which writes art history at the threshold of contemporary art, is summoned, on the contrary, to give evidence of an intact, though profoundly transformed, aesthetic engagement by the artist.

  3. Doped Fountain Coding for Minimum Delay Data Collection in Circular Networks

    CERN Document Server

    Kokalj-Filipovic, Silvija; Soljanin, Emina

    2010-01-01

    This paper studies decentralized, Fountain and network-coding based strategies for facilitating data collection in circular wireless sensor networks, which rely on the stochastic diversity of data storage. The goal is to allow for a reduced delay collection by a data collector who accesses the network at a random position and random time. Data dissemination is performed by a set of relays which form a circular route to exchange source packets. The storage nodes within the transmission range of the route's relays linearly combine and store overheard relay transmissions using random decentralized strategies. An intelligent data collector first collects a minimum set of coded packets from a subset of storage nodes in its proximity, which might be sufficient for recovering the original packets and, by using a message-passing decoder, attempts recovering all original source packets from this set. Whenever the decoder stalls, the source packet which restarts decoding is polled/doped from its original source node. T...

  4. Stability enhancement by joint phase measurements in a single cold atomic fountain

    CERN Document Server

    Meunier, M; Geiger, R; Guerlin, C; Alzar, C L Garrido; Landragin, A

    2015-01-01

    We propose a method of joint interrogation in a single atom interferometer which overcomes the dead time between consecutive measurements in standard cold atomic fountains. The joint operation enables for a faster averaging of the Dick effect associated with the local oscillator noise in clocks and with vibration noise in cold atom inertial sensors. Such an operation allows achieving the lowest stability limit due to atom shot noise. We demonstrate a multiple joint operation in which up to five clouds of atoms are interrogated simultaneously in a single setup. The essential feature of multiple joint operation, demonstrated here for a micro-wave Ramsey interrogation, can be generalized to go beyond the current stability limit associated with dead times in present-day cold atom interferometer inertial sensors.

  5. Pen Torch Transillumination: Difficult Venepuncture Made Easy.

    Science.gov (United States)

    Cai, Elijah Zhengyang; Sankaran, Kalarani; Tan, Monica; Chan, Yiong Huak; Lim, Thiam Chye

    2017-09-01

    Our novel technique of pen torch transillumination (PTI) uses a cheap and easily available instrument (Penlite-LP212(®), Energizer(®), Missouri, USA) to visualize superficial veins invisible to the naked eye. We evaluate the efficacy of PTI in improving venepuncture success rate (SR) for patients with poor venous access. This prospective randomized controlled trial looked at adult patients (n = 69) aged 21-90 with difficult venous access (history of ≥3 consecutive attempts required for successful cannulation during the current admission) requiring non-emergent venepuncture. Patients underwent venepuncture over the upper-limb using one of the following: conventional venepuncture (control); Veinlite(®) EMS (TransLite(®), Texas, USA), a commercial transillumination device; PTI. Outcome measures were: successful cannulation within 2 attempts and total duration of venepuncture. Fisher's exact and Kruskal-Wallis tests were performed. A significantly larger number of patients had successful venepuncture within 2 attempts using PTI (22/23, 95.7%) and Veinlite (23/23, 100%), compared to the controls (7/23, 30.4%) (p < 0.05). The total duration required for successful venepuncture was significantly shorter for Veinlite (mean 3.7 min, 1.0-5.3 min) and PTI (mean 8.5 min, range 1.08-27 min) compared to the controls (mean 23.2 min, range 1.88-46.5 min) (p < 0.05). PTI allows users to visualize veins invisible to the naked eye. Thrombosed/tortuous veins, branch points and valves, are easily identified and avoided. It has comparable efficacy to Veinlite(®) and is cheaper (Veinlite(®)-USD 227 vs. Penlite-LP212(®)-USD 7.00) and more easily available. PTI improves patient care, especially in developing regions where costs are a concern.

  6. Magma mixing and high fountaining during the 1959 Kīlauea Iki eruption, Hawai‘i

    Science.gov (United States)

    Sides, I.; Edmonds, M.; Maclennan, J.; Houghton, B. F.; Swanson, Don; Steele-MacInnis, M.J.

    2014-01-01

    The 1959 Kīlauea Iki eruption provides a unique opportunity to investigate the process of shallow magma mixing, its impact on the magmatic volatile budget and its role in triggering and driving episodes of Hawaiian fountaining. Melt inclusions hosted by olivine record a continuous decrease in H2O concentration through the 17 episodes of the eruption, while CO2 concentrations correlate with the degree of post-entrapment crystallization of olivine on the inclusion walls. Geochemical data, when combined with the magma budget and with contemporaneous eruption observations, show complex mixing between episodes involving hot, geochemically heterogeneous melts from depth, likely carrying exsolved vapor, and melts which had erupted at the surface, degassed and drained-back into the vent. The drained-back melts acted as a coolant, inducing rapid cooling of the more primitive melts and their olivines at shallow depths and inducing crystallization and vesiculation and triggering renewed fountaining. A consequence of the mixing is that the melts became vapor-undersaturated, so equilibration pressures cannot be inferred from them using saturation models. After the melt inclusions were trapped, continued growth of vapor bubbles, caused by enhanced post-entrapment crystallization, sequestered a large fraction of CO2 from the melt within the inclusions. This study, while cautioning against accepting melt inclusion CO2 concentrations “as measured” in mixed magmas, also illustrates that careful analysis and interpretation of post-entrapment modifications can turn this apparent challenge into a way to yield novel useful insights into the geochemical controls on eruption intensity.

  7. Bioaccumulation of Selenium by the Bryophyte Hygrohypnum ochraceum in the Fountain Creek Watershed, Colorado

    Science.gov (United States)

    Herrmann, S. J.; Turner, J. A.; Carsella, J. S.; Lehmpuhl, D. W.; Nimmo, D. R.

    2012-12-01

    Aquatic bryophytes, Hygrohypnum ochraceum, were deployed "in situ" at 14 sites in the Fountain Creek Watershed, spring and fall, 2007 to study selenium (Se) accumulation. Dissolved, total, and pore (sediment derived) water samples were collected and water quality parameters determined while plants were exposed to the water for 10 days. There was a trend showing plant tissue-Se uptake with distance downstream and we found a strong correlation between Se in the water with total hardness in both seasons. There was a modest association between Se-uptake in plants with hardness in the spring of 2007 but not the fall. Plants bioconcentrated Se from the water by a factor of 5.8 × 103 at Green Mountain Falls and 1.5 × 104 at Manitou Springs in the fall of 2007. Both are examples of the bioconcentration abilities of the plants, primarily in the upper reaches of the watershed where bioconcentration factors were highest. However, the mean minima and maxima of Se in the plants in each of the three watershed segments appeared similar during both seasons. We found direct relationships between the pore and dissolved Se in water in the spring ( R 2 = 0.84) and fall ( R 2 = 0.95) and dissolved Se and total hardness in the spring and fall ( R 2 = 0.92). The data indicate that H. ochraceum was a suitable indicator of Se bioavailability and Se uptake in other trophic levels in the Fountain Creek Watershed based on a subsequent study of Se accumulation in fish tissues at all 14 sites.

  8. Characterization of recombinant shrimp allergen Pen a 1 (tropomyosin).

    Science.gov (United States)

    Reese, G; Jeoung, B J; Daul, C B; Lehrer, S B

    1997-01-01

    Tropomyosin (Pen a 1) from brown shrimp, Penaeus aztecus, has been identified as the only major shrimp allergen. Since beef, pork and chicken are other tropomyosin-containing foods that are not very allergenic, tropomyosins can serve to investigate the contribution of the structural properties of a protein to its allergenicity. The aim of this study was to determine the primary structure of Pen a 1 and to identify IgE-binding epitopes. The screening of a unidirectional expression cDNA library from shrimp tail muscle with the Pen-a-1-specific monoclonal antibody 4.9.5 resulted in 4 positive Escherichia coli clones. Immunoblot analysis with human sera from shrimp-allergic subjects demonstrated IgE binding of all 4 recombinant shrimp proteins. Three of 4 expressed recombinant proteins have a molecular weight of approximately 36 kD, consistent with the molecular weight of natural Pen a 1. The DNA sequence analysis identified these recombinant shrimp proteins as tropomyosin and could be aligned with the sequence of greasyback shrimp (Metapenaeus ensis) tropomyosin (Met e 1). In order to characterize contiguous IgE-binding epitopes of Pen a 1, a peptide library (Novagen epitope mapping system) expressing 10-30 amino-acid-residue-long recombinant Pen a 1 peptides was constructed and screened with human IgE. Four recombinant, IgE-reactive Pen a 1 peptides were selected and sequenced. They show various degrees of sequence identity with tropomyosins of other arthropods, such as fruitfly and house dust mite, helminths and vertebrates.

  9. Microfabricated Arrays for Splitting and Assay of Clonal Colonies

    Science.gov (United States)

    Gach, Philip C.; Xu, Wei; King, Samantha J.; Sims, Christopher E.; Bear, James; Allbritton, Nancy L.

    2012-01-01

    A microfabricated platform was developed for highly parallel and efficient colony picking, splitting and clone identification. A pallet array provided patterned cell colonies which mated to a second printing array composed of bridging microstructures formed by a supporting base and attached post. The posts enabled mammalian cells from colonies initially cultured on the pallet array to migrate to corresponding sites on the printing array. Separation of the arrays simultaneously split the colonies creating a patterned replica. Optimization of array elements provided transfer efficiencies greater than 90% using bridging posts of 30 μm diameter and 100 μm length and total colony numbers of 3000. Studies using five mammalian cell lines demonstrated that a variety of adherent cell types could be cultured and effectively split with printing efficiencies of 78–92%. To demonstrate the technique’s utility, clonal cell lines with siRNA knockdown of Coronin 1B were generated using the arrays and compared to a traditional FACS/Western Blotting-based approach. Identification of target clones required a destructive assay to identify cells with an absence of Coronin 1B brought about by the successful infection of interfering shRNA construct. By virtue of miniaturization and its parallel format, the platform enabled the identification and generation of 12 target clones from a starting sample of only 3900 cells and required only 5-man hours over 11 days. In contrast, the traditional method required 500,000 cells and generated only 5 target clones with 34-man hours expended over 47 days. These data support the considerable reduction in time, manpower and reagents using the miniaturized platform for clonal selection by destructive assay versus conventional approaches. PMID:23153031

  10. The maximum life expectancy for a micro-fabricated diaphragm

    Science.gov (United States)

    Cǎlimǎnescu, Ioan; Stan, Liviu-Constantin; Popa, Viorica

    2015-02-01

    Micro-fabricated diaphragms can be used to provide pumping action in microvalve and microfluidic applications. The functionality of the microdiaphragm in a wirelessly actuated micropump plays a major role in low-powered device actuation. In developing micropumps and their components, it is becoming an increasing trend to predict the performance before the prototype is fabricated. Because performance prediction allows for an accurate estimation of yield and lifetime, in addition to developing better understanding of the device while taking into account the details of the device structure and second order effects. Hence avoid potential pitfalls in the device operation in a practical environment. The goal of this research is to determine via FEA the life expectancy for a corrugated circular diaphragm made out of an aluminum alloy. The geometry of the diaphragm is given below being generated within SolidWorks 2010, all the calculations were made using Ansys 13TM . The sound design of a micropump is heavily depending on the lifetime expectancy of the working part of the device which is the diaphragm. This will be subjected on cyclic loading and the fatigue will limit the life of this part. Once the diaphragm is breaking, the micropump is no more able to fulfill its scope. Any micropump manufacturer will then be very concerned on the life expectancy from the fatigue point of view of the diaphragms. The diaphragm circular and corrugated and made of Al alloy, showed a very good behavior from the fatigue point of view, the maximum life expectancy being 1.9 years of continuous functioning with 100 cycles per second. This work showed an simple and forward application of FEA analysis methods in order to estimate the fatigue behavior of corrugated circular microdiaphragms.

  11. Understanding differences in access to water fountains and sugar-sweetened beverages in children׳s environments: a pilot study in high and low deprivation neighbourhoods.

    Science.gov (United States)

    Pearson, Amber L; de Latour, Phillip; Kemp, Gabrielle; Findlay, Nohoana; Halim, Angela; Atkinson, Nicola; Chong, Mark; Cameron, Rose; Brown, Courtney; Kim, Grace; Campbell, Paul; Hills, Toby; Jayawant, Aditya; Chae, Matthew; Bhagavan, Chiranth; French, Claire; Jenkin, Gabrielle; Smith, Moira; Signal, Louise

    2014-11-01

    Access to water fountains and sugar-sweetened beverages (SSBs) in children׳s environments may impact on child obesity and may vary with neighbourhood deprivation. Our pilot analyses of access to water fountains and SSBs in Wellington, New Zealand revealed that water fountain access was high in school environments and low in recreational environments. There were also differences in water fountain and SSB access points by neighbourhood deprivation. The methods piloted in this study could be translated in a larger study, more capable of detecting significant differences in access and allowing for more sophisticated analyses. Such future studies may provide important evidence for the improvement of children׳s health and well-being.

  12. The LongPen--the world's first original remote signing device.

    Science.gov (United States)

    Kruger, Diane M

    2010-05-01

    The LongPen is a remote-controlled pen and videoconferencing device conceived by Canadian author Margaret Atwood in 2004 and initially intended to bring "live" author signings to far away locations. The LongPen allows for individually inscribed long distance signatures and writing while maintaining an original record, written with pen and ink. LongPen specimens were compared with control specimens using different speeds, pen pressures, and types of pens. Preliminary indications are that LongPen inscriptions can be identified or associated with their author. Size and form are maintained and artifacts are subtle. Some limitations with respect to the capture of long tapered strokes, delicate connecting strokes, and differences in line width were noted. Factors which may impact forensic handwriting examinations include limited amounts of writing, light pen pressure, date of the writing, type of writing instrument, dimensions of the writing, and failure to consider that the device has been used.

  13. Picking among pen-reared quail

    Science.gov (United States)

    Nestler, R.B.; Coburn, D.R.; Titus, H.W.

    1945-01-01

    During five years (1939-43) of nutritional research on pen-reared bobwhite quail at the Patuxent Research Refuge, Bowie, Maryland, observations on picking among birds of all ages showed the following results: 1. Picking occurred on all grains tested: corn, wheat, oats, oat groats, barley, millet, buckwheat, kaffir, and mixtures of cereals. The lowest incidence was with buckwheat as the sole grain in a growing diet....2. Picking occurred on all levels of fiber from one to 11per cent in a growing diet....3. Picking occurred on various grinds of corn, barley, and oats, but was least when these cereals were ground in a hammer mill with 3/32 inch mesh screen....4. The incidence was as high on diets containing animal protein as on those containing no animal protein. ....5. After picking began, the addition of one or two per cent of salt to the diet for several days was effective, in many instances, in checking the disorder. Results at the Refuge and the answers to questionnaires from 222 private propagators of gamebirds showed that in two-thirds. of the cases, treatment with an increased quantity of salt successfully stopped the trouble. As a preventative, however, salt was of little value. Picking occurred on both low and high levels of salt.....6. Supplementing the regular diet with certain feed concentrates such as fishmeal, soybean oil meal, liver meal, or chopped greens offered in a separate feeder for a day or two, was as efficacious as the addition of salt.....7. More picking occurred among quail chicks on a 22 per cent level of protein than on higher levels.....8. There was less picking on diets relished by the birds than on those seemingly unpalatable.....9. There was no correlation. between the amount of floor space per chick and the incidence of picking.....10. Increasing the feeding and drinking space seemed to have a marked beneficial effect.....11. Some adult birds on wire floors resorted to self-picking of their feet after the toes were frost-bitten.

  14. Simulations and design of microfabricated interdigitated electrodes for use in a gold nanoparticle enhanced biosensor.

    Science.gov (United States)

    Hermansen, Peter; MacKay, Scott; Wishart, David; Jie Chen

    2016-08-01

    Microfabricated interdigitated electrode chips have been designed for use in a unique gold-nanoparticle based biosensor system. The use of these electrodes will allow for simple, accurate, inexpensive, and portable biosensing, with potential applications in diagnostics, medical research, and environmental testing. To determine the optimal design for these electrodes, finite element analysis simulations were carried out using COMSOL Multiphysics software. The results of these simulations determined some of the optimal design parameters for microfabricating interdigitated electrodes as well as predicting the effects of different electrode materials. Finally, based on the results of these simulations two different kinds of interdigitated electrode chips were made using photolithography.

  15. Early warning of diarrhea and pen fouling in growing pigs using sensor-based monitoring

    DEFF Research Database (Denmark)

    Jensen, D. B.; Toft, N.; Kristensen, A. R.

    Introduction: Today, pig farmers typically asses the health of their pigs while walking through their herd as part of the daily routine. In modern pig production, however, a herd will consists of thousands of pigs in a few hundred pens. If a farmer were to spend just two minutes observing each pen...... positions per pen (hourly), water flow per double-pen (liters/hour/pig) and drinking frequency per pen (activations/hour/pig). Staff registrations of diarrhea and pen fouling were the events of interest. The data were divided into a learning set (15 events) and a test set (18 events). The data were modeled...

  16. Assessment of drinking-water waste in electric drinking fountains by students of a public school in Cabo Frio, RJ

    Directory of Open Access Journals (Sweden)

    Ocimar Ferreira de Andrade

    2013-01-01

    Full Text Available iscussion of issues aiming at alerting society about factors that cause risks to the biosphere and its inhabitants is extremely important for the development of scientific studies. It is necessary that society be aware of possible actions in order to conserve water and eliminate waste of this precious natural resource. Aiming at cooperating with this process, a research was carried out with 381 students in a public school in Cabo Frio, Rio de Janeiro. The study showed the inadequate use of electric pressure drinking fountains, and the resulting waste of water. Results indicate an annual waste of approximately 47,790 liters of water related to the use of fountains by the 810 students attending morning classes.

  17. Study of Ammonia Emissions in a Ventilated Pig Pen

    DEFF Research Database (Denmark)

    Rong, Li

    Pig productions cause a wide emission of odors, such as ammonia (NH3), hydrogen sulfide (H2S), and methane (CH4). Ammonia is one of the most important emissions for evaluating the air quality either in animal buildings or atmospheric environment. In studies of ammonia emission from animal buildings...... solution temperatures. The results show that the diffusive ceiling ventilation system can provide a relative low velocity in the pig pen and decrease ammonia emissions from the pig pen, but this ventilation system causes high ammonia concentration distribution in the animal occupied zone. Further, our...... reported in literature, little effort has been made to investigate the accuracy of current Henry’s law constant for modeling ammonia mass transfer process and study ammonia emissions in a full scale pig pen from fluid dynamics by CFD simulations. This will be the main objectives of this study. The ammonia...

  18. Fabrication of Luminescent Nanostructures by Dip-Pen Nanolithography

    Energy Technology Data Exchange (ETDEWEB)

    Noy, A; Miller, A E; Klare, J E; Weeks, B L; Woods, B W; DeYoreo, J J

    2002-06-25

    We used a combination of dip-pen nanolithography and scanning optical confocal microscopy to fabricate and visualize luminescent nanoscale patterns of various materials on glass substrates. We show that this method can be used successfully to push the limits of dip-pen nanolithography down to controlled deposition of single molecules. We also demonstrate that this method is able to create and visualize protein patterns on surfaces. Finally, we show that our method can be used to fabricate polymer nanowires of controlled size using conductive polymers. We also present a kinetic model that accurately describes the deposition process.

  19. Lorentz-violating spinor electrodynamics and Penning traps

    CERN Document Server

    Ding, Yunhua

    2016-01-01

    The prospects are explored for testing Lorentz- and CPT-violating quantum electrodynamics in experiments with Penning traps. We present the Lagrange density of Lorentz-violating spinor electrodynamics with operators of mass dimensions up to six, and we discuss some of its properties. The theory is used to derive Lorentz- and CPT-violating perturbative shifts of the energy levels of a particle confined to a Penning trap. Observable signals are discussed for trapped electrons, positrons, protons, and antiprotons. Existing experimental measurements on anomaly frequencies are used to extract new or improved bounds on numerous coefficients for Lorentz and CPT violation, using sidereal variations of observables and comparisons between particles and antiparticles.

  20. Fountain streaming contributes to fast tip-growth through regulating the gradients of turgor pressure and concentration in pollen tubes.

    Science.gov (United States)

    Liu, ShaoBao; Liu, Han; Feng, ShangSheng; Lin, Min; Xu, Feng; Lu, Tian Jian

    2017-04-19

    Fountain streaming is a typical microfluidic pattern in plant cells, especially for cells with a high aspect ratio such as pollen tubes. Although it has been found that fountain streaming plays crucial roles in the transport of nutrients and metabolites, the positioning of organelles and the mixing of cytoplasms, its implications for the fast tip growth of pollen tubes remain a mystery. To address this, based on the observations of asiatic lily Lilium Casablanca, we developed physical models for reverse fountain streaming in pollen tubes and solved the hydrodynamics and advection-diffusion dynamics of viscous Stokes flow in the shank and apical region of pollen tubes. Theoretical and numerical results demonstrated that the gradients of turgor pressure and concentration of wall materials along the length of pollen tubes provide undamped driving force and high-efficiency materials supply, which are supposed to contribute to the fast tip-growth of pollen tubes. The sample experimental results show that the tip-growth will be abnormal when the gradients of turgor pressure change under osmotic stress induced by different concentrations of PEG-6000 (a dehydrant).

  1. Flooding in the South Platte River and Fountain Creek Basins in eastern Colorado, September 9–18, 2013

    Science.gov (United States)

    Kimbrough, Robert A.; Holmes, Jr., Robert R.

    2015-11-25

    On September 9, 2013, rain began to fall in eastern Colorado as a large low-pressure system pulled plumes of tropical moisture northward from the Pacific Ocean and the Gulf of Mexico. By September 16, 2013, as much as 12 to 20 inches of rain had fallen in the foothills of the Front Range of the Southern Rocky Mountains and adjacent plains near Colorado Springs, Colorado, north to the Colorado-Wyoming border. The rain caused major flooding during September 9–18, 2013, in a large part of the South Platte River Basin and in the Fountain Creek Basin. The floods resulted in several fatalities, more than 31,000 damaged or destroyed structures, and an estimated 3 billion dollars in damages. The U.S. Geological Survey (USGS) documented peak stage, streamflow, or both from the flood event for 80 sites located on selected rivers and streams in the South Platte River and Fountain Creek Basins and on the Platte River in Nebraska. The majority of flood-peak streamflows occurred on September 12 or 13, 2013, coinciding with the period of maximum rainfall. The flood resulted in new record peak streamflows at 17 streamgages having at least 10 years of record; 13 in the South Platte River Basin and 4 in the Fountain Creek Basin.

  2. Biological Macro and Micro Systems Co-existing in the “Fountain of the Two Dragons”, Palermo

    Directory of Open Access Journals (Sweden)

    Enza Di Carlo

    2017-06-01

    Full Text Available Stone works of art located outdoors are exposed to natural deterioration, due to several physical, chemical and biological factors. Biological macro- and micro-systems (e.g. weeds, insects, algae, mosses, fungi and bacteria may induce the biodeterioration of stone materials. In February 2014, the state of conservation of the Fountain of the two Dragons in Palermo was examined, during which time biological colonization in some areas of the fountain and statues, was also detected. The monument represents an excellent substrate for the development and growth of microrganisms and organisms that need a continuous supply of water. Direct solar irradiance promotes the development of photoautotrophic organisms, bryophyte flora, in addition to several microbial genera, responsible for pigmentation, discoloring, efflorescence. After autotrophic colonization, some organisms find an ideal habitat also during wintertime, including two species of gastropods and two species of Hemiptera, omnivorous, a species of Collembola, mostly fungivorous. This interdisciplinary study has enabled the detection and identification of different biological communities, providing information for a subsequent project of preventive conservation of the fountain and its surroundings.

  3. Revisiter le renouveau religieux dans le développement : une critique de Philip Fountain

    Directory of Open Access Journals (Sweden)

    Katherine Marshall

    2013-04-01

    Full Text Available L’article de Philip Fountain, complexe s’il en est et profond à bien des égards, aborde un ensemble de questions auxquelles se heurtent aujourd’hui bon nombre d’acteurs dans le large éventail d’institutions et de visions du monde divergentes. Il débute et conclut son article par une réflexion sur la « découverte » de la religion par les communautés du développement. Il affirme que les définitions plus que généralisées, bâclées dirais-je même, de la religion sont monnaie courante. Et de déduire que derrière ces nombreux traitements de la « religion » se cache « une certaine conceptualisation par défaut – substantialiste, essentialisée, sans fondement historique et universelle ». Il propose un argument important : là où les vastes sphères complexes de la religion sont présentes, les catégorisations simplistes sont trompeuses et chargées d’un lourd bagage politique. Si j’abonde totalement dans son sens sur le premier point, je reste par contre bien moins convaincue que des politiques néfastes soient à l’œuvre au niveau qu’il suggère dans ses efforts pour conceptualiser le chevauchement entre les sphères du développement et de la croyance. Je dirais, pour ma part, que les caractérisations simplistes des vastes sphères complexes du développement international sont autant chargées que les grandes généralisations sur la religion. L’article de Philip Fountain pèche à mon sens par sa caractérisation insuffisante du développement. Il appelle à un examen critique du « développement laïque », sans toutefois en préciser les contours. (…

  4. Low voltage electroosmotic pump for high density integration into microfabricated fluidic systems

    NARCIS (Netherlands)

    Heuck, F.C.A.; Staufer, U.

    2011-01-01

    A low voltage electroosmotic (eo) pump suitable for high density integration into microfabricated fluidic systems has been developed. The high density integration of the eo pump required a small footprint as well as a specific on-chip design to ventilate the electrolyzed gases emerging at the platin

  5. MICROFABRICATED ELECTROCHEMICAL ANALYSIS SYSTEM FOR HEAVY METAL DETECTION. (R825511C047)

    Science.gov (United States)

    A low power, hand-held system has been developed for the measurement of heavy metal ions in aqueous solutions. The system consists of an electrode array sensor, a high performance single chip potentiostat and a microcontroller circuit. The sensor is a microfabricated array of ...

  6. A self-assembled monolayer-assisted surface microfabrication and release technique

    NARCIS (Netherlands)

    Kim, B.J.; Liebau, M.; Huskens, J.; Reinhoudt, D.N.; Brugger, J.P.

    2001-01-01

    This paper describes a method of thin film and MEMS processing which uses self-assembled monolayers as ultra-thin organic surface coating to enable a simple removal of microfabricated devices off the surface without wet chemical etching. A 1.5-nm thick self-assembled monolayer of dodecyltrichlorosil

  7. PtRu colloid nanoparticles for CO oxidation in microfabricated reactors

    DEFF Research Database (Denmark)

    Klerke, Asbjørn; Saadi, Souheil; Toftegaard, Maja Bøg

    2006-01-01

    The catalytic activity of PtRu colloid nanoparticles for CO oxidation is investigated in microfabricated reactors. The measured catalytic performance describes a volcano curve as a function of the Pt/Ru ratio. The apparent activation energies for the different alloy catalysts are between 21 and 117...

  8. Early warning of diarrhea and pen fouling in growing pigs using sensor-based monitoring

    DEFF Research Database (Denmark)

    Jensen, D. B.; Toft, N.; Kristensen, A. R.

    as the area under the receiver operating characteristics curve (AUC). Results: We achieved an AUC of 0.83 when all variables were included. Omitting live weight and humidity had no effect. Omitting drinking behavior, temperature, and feed usage reduced the AUC to 0.70, 0.81, and 0.82 respectively. Conclusion...... then identify specific pens in need of extra attention. Here we evaluate the value of monitoring live weight, feed usage, humidity, drinking behavior and pen temperature in relation to early warnings of diarrhea and pen fouling in slaughter pigs. Materials and methods: We used data collected in 16 pens (8...... double-pens) between November 2013 and December 2014 at a commercial Danish farm. During this time, three new batches were inserted. We monitored the mean live weight of the pigs per pen (weekly, only in 4 pens), feed usage per double-pen (daily), humidity per section (daily), temperature at two...

  9. Lonely drinking fountains and comforting coolers: paradoxes of water value and ironies of water use.

    Science.gov (United States)

    Kaplan, Martha

    2011-01-01

    This article focuses ethnographically on Americans and technologies of drinking water, as tokens of and vehicles for health, agency, and surprising kinds of community. Journalists and water scholars have argued that bottled water is a material concomitant of privatization and alienation in U.S. society. But, engaging Latour, this research shows that water technologies and the groups they assemble, are plural. Attention to everyday entwining of workplace lives with drinking fountains, single-serve bottles, and spring water coolers shows us several different quests, some individualized, some alienated, but some seeking health via public, collective care, acknowledgment of stakeholding, and community organizing. Focused on water practices on a college campus, in the roaring 1990s and increasingly sober 2000s in the context of earlier U.S. water histories of inclusion and exclusion, I draw on ethnographic research from the two years that led up to the recession and the presidential election of 2008. I argue for understanding of water value through attention to water use, focusing both on the social construction of water and the use of water for social construction.

  10. UTC(OP) based on LNE-SYRTE atomic fountain primary frequency standards

    Science.gov (United States)

    Rovera, G. D.; Bize, S.; Chupin, B.; Guéna, J.; Laurent, Ph; Rosenbusch, P.; Uhrich, P.; Abgrall, M.

    2016-06-01

    UTC(OP), the French national realization of the international coordinated universal time, was redesigned and rebuilt. The first step was the implementation in October 2012 of a new algorithm based on a H-maser and on atomic fountain data. Thanks to the new implementation, the stability of UTC(OP) was dramatically improved and UTC(OP) competes with the best time scales available today. Then the hardware generation and distribution of the UTC(OP) physical signals were replaced. Part of the new hardware is composed of commercial devices, but the key elements were specifically developed. One of them is a special switch that allows the UTC(OP) signals to be derived from one of two time scales, based on two different H-masers, which are generated simultaneously. This insures the continuity of the UTC(OP) signal even when a change of the reference H-maser is required. With the new hardware implementation, UTC(OP) is made available through three coherent signals: 100 MHz, 10 MHz and 1 PPS. For more than 3 years, UTC(OP) remained well below 10 ns close to UTC, with a difference even less than 5 ns if we except a short period around MJD 56650.

  11. Proper Motions of H2O Masers in the Water Fountain Source IRAS 19190+1102

    CERN Document Server

    Day, F M; Claussen, M J; Sahai, R

    2010-01-01

    We report on the results of two epochs of Very Long Baseline Array (VLBA) observations of the 22 GHz water masers toward IRAS 19190+1102. The water maser emission from this object shows two main arc-shaped formations perpendicular to their NE-SW separation axis. The arcs are separated by ~280 mas in position, and are expanding outwards at an angular rate of 2.35 mas/yr. We detect maser emission at velocities between -53.3 km/s to +78.0 km/s and there is a distinct velocity pattern where the NE masers are blueshifted and the SW masers are redshifted. The outflow has a three-dimensional outflow velocity of 99.8 km/s and a dynamical age of about 59 yr. A group of blueshifted masers not located along the arcs shows a change in velocity of more than 35 km/s between epochs, and may be indicative of the formation of a new lobe. These observations show that IRAS 19190+1102 is a member of the class of "water fountain"' pre-planetary nebulae displaying bipolar structure

  12. Improved tests of Local Position Invariance using 87Rb and 133Cs fountains

    CERN Document Server

    Guéna, Jocelyne; Rovera, Daniele; Rosenbusch, Peter; Tobar, Michael E; Laurent, Philippe; Clairon, André; Bize, Sébastien

    2012-01-01

    We report tests of Local Position Invariance (LPI) based on measurements of the ratio of the ground state hyperfine frequencies of 133Cs and 87Rb in laser-cooled atomic fountain clocks. Measurements extending over 14 years set a stringent limit to a possible variation with time of this ratio: d ln(nu_Rb/nu_Cs)/dt=(-1.39 +/- 0.91)x 10-16 yr-1. This improves by a factor of 7.7 over our previous report (H. Marion et al.}, Phys. Rev. Lett. 90, 150801 (2003)). Our measurements also set the first limit to a fractional variation of the Rb/Cs ratio with gravitational potential at the level of c^2 d ln(nu_Rb/nu_Cs)/dU=(0.11 +/- 1.04)x 10^-6, providing a new stringent differential redshift test. The above limits equivalently apply to the fractional variation of the quantity alpha^{-0.49}x(g_Rb/g_Cs), which involves the fine structure constant alpha and the ratio of the nuclear g-factors of the two alkalis. The link with variations of the light quark mass is also presented together with a global analysis combining with ...

  13. Hierarchical formation of bulgeless galaxies II: Redistribution of angular momentum via galactic fountains

    CERN Document Server

    Brook, C B; Gibson, B K; Roškar, R; Wadsley, J; Quinn, T

    2011-01-01

    Within a fully cosmological hydrodynamical simulation, we form a galaxy which rotates at 140 km/s, and is characterised by two loose spiral arms and a bar, indicative of a Hubble Type SBc/d galaxy. We show that our simulated galaxy has no classical bulge, with a pure disc profile at z=1, well after the major merging activity has ended. A long-lived bar subsequently forms, resulting in the formation of a secularly-formed "pseudo" bulge, with the final bulge-to-total light ratio B/T=0.21. We show that the majority of gas which loses angular momentum and falls to the central region of the galaxy during the merging epoch is blown back into the hot halo, with much of it returning later to form stars in the disc. We propose that this mechanism of redistribution of angular momentum via a galactic fountain, when coupled with the results from our previous study which showed why gas outflows are biased to have low angular momentum, can solve the angular momentum/bulgeless disc problem of the cold dark matter paradigm.

  14. Revisiting the Religious Revival in Development: A Critique of Philip Fountain (abstract

    Directory of Open Access Journals (Sweden)

    Katherine Marshall

    2013-02-01

    Full Text Available Philip Fountain has written a challenging and, in places, thoughtful chapter that touches on a set of issues that currently challenge actors across a wide spectrum of differing institutions and world views. Fountain’s beginning and ending points are his reflections on the ‘discovery’ of religion by development communities. He argues that overgeneralised – I would even say sloppy – definitions of religion are commonplace. He goes on to deduce that what underlies many treatments of ‘religion’ is ‘a default conceptualisation – substantivist, essentialised, ahistorical and universal’. He makes an important argument: that where the vast and complex worlds of religion are involved, simplistic categorisations are misleading and laden with great political baggage. I agree entirely with the first point, but am far less convinced that nefarious politics are at work to the degree he suggests in his efforts to conceptualise the overlap among development and faith worlds. I would argue, in fact, that simplistic characterisations of the vast and complex worlds of international development are as similarly fraught as broad generalisations regarding religion. Fountain’s chapter is weakest, in my view, in its characterisations of development. He calls for a critical examination of ‘secular development’ but gives few indications as to what, precisely, that would involve.(…

  15. Do water fountain jets really indicate the onset of the morphological metamorphosis of circumstellar envelopes?

    Science.gov (United States)

    Yung, Bosco H. K.; Nakashima, Jun-ichi; Hsia, Chih-Hao; Imai, Hiroshi

    2017-03-01

    Small-scale bipolar jets with short dynamical ages from 'water-fountain' (WF) sources are regarded as an indication of the onset of circumstellar envelope morphological metamorphosis of intermediate-mass stars. Such a process usually happens at the end of the asymptotic giant branch (AGB) phase. However, recent studies found that WFs could be AGB stars or even early planetary nebulae. This fact prompted the idea that WFs may not necessarily be objects at the beginning of the morphological transition process. In the present work, we show that WFs could have different envelope morphologies by studying their spectral energy distribution profiles. Some WFs have spherical envelopes that resemble usual AGB stars, while others have aspherical envelopes, which are more common to post-AGB stars. The results imply that WFs may not represent the earliest stage of morphological metamorphosis. We argue further that the dynamical age of a WF jet, which can be calculated from maser proper motions, may not be the real age of the jet. The dynamical age cannot be used to justify the moment when the envelope begins to become aspherical, nor to tell the concrete evolutionary status of the object. A WF jet could be the innermost part of a larger well-developed jet, which is not necessarily a young jet.

  16. Do Water Fountain Jets Really Indicate the Onset of the Morphological Metamorphosis of Circumstellar Envelopes?

    CERN Document Server

    Yung, Bosco H K; Hsia, Chih-Hao; Imai, Hiroshi

    2016-01-01

    The small-scale bipolar jets having short dynamical ages from "water fountain (WF)" sources are regarded as an indication of the onset of circumstellar envelope morphological metamorphosis of intermediate-mass stars. Such process usually happens at the end of the asymptotic giant branch (AGB) phase. However, recent studies found that WFs could be AGB stars or even early planetary nebulae. This fact prompted the idea that WFs may not necessarily be objects at the beginning of the morphological transition process. In the present work, we show that WFs could have different envelope morphologies by studying their spectral energy distribution profiles. Some WFs have spherical envelopes that resembles usual AGB stars, while others have aspherical envelopes which are more common to post-AGB stars. The results imply that WFs may not represent the earliest stage of the morphological metamorphosis. We further argue that the dynamical age of a WF jet, which can be calculated from maser proper motions, may not be the rea...

  17. Strong ambipolar-driven ion upflow within the cleft ion fountain during low geomagnetic activity

    Science.gov (United States)

    Shen, Yangyang; Knudsen, David J.; Burchill, Johnathan K.; Howarth, Andrew; Yau, Andrew; Redmon, Robert J.; Miles, David M.; Varney, Roger H.; Nicolls, Michael J.

    2016-07-01

    We investigate low-energy (CIF) using conjunctions of the Enhanced Polar Outflow Probe (e-POP) satellite, the DMSP F16 satellite, the SuperDARN radar, and the Resolute Bay Incoherent Scatter Radar North (RISR-N). The SEI instrument on board e-POP enables us to derive ion upflow velocities from the 2-D images of ion distribution functions with a frame rate of 100 images per second, and with a velocity resolution of the order of 25 m/s. We identify three cleft ion fountain events with very intense (>1.6 km/s) ion upflow velocities near 1000 km altitude during quiet geomagnetic activity (Kp CIF does not rise by more than 0.3 eV relative to background values, which is consistent with RISR-N observations in the F region. The presence of soft electron precipitation seen by DMSP and lack of significant ion heating indicate that the ion upflows we observe near 1000 km altitude are primarily driven by ambipolar electric fields. DC field-aligned currents (FACs) and convection velocity gradients accompany these events. The strongest ion upflows are associated with downward current regions, which is consistent with some (although not all) previously published results. The moderate correlation coefficient (0.51) between upflow velocities and currents implies that FACs serve as indirect energy inputs to the ion upflow process.

  18. Notas sobre la Penélope de la Odisea

    OpenAIRE

    López Férez, Juan Antonio

    2011-01-01

    27 p. Penélope aparece mencionada ochenta y tres veces en la Odisea. En este artículo se revisan los pasajes más destacados, subrayando los detalles que puedan contribuir a esclarecer la figura de la heroina desde distintos puntos de vista

  19. Testing Lorentz and CPT Symmetries in Penning Traps

    CERN Document Server

    Ding, Yunhua

    2016-01-01

    A modified Dirac equation with general Lorentz- and CPT-violating operators in the electromagnetic field is studied. Constraints on and possible sensitivities to Lorentz-violating coefficients in the nonminimal sector up to mass-dimension six can be obtained by analyzing Penning-trap results involving anomaly frequencies.

  20. Where's your pen pal from?教学设计

    Institute of Scientific and Technical Information of China (English)

    潘淑霞

    2005-01-01

    @@ 教材:新课标七年级(下册) Unit One Where's your pen pal from? Section A 教学目标: 1.学习表示一些国家名称和城市名称的词汇.如:Canada,France,Australia,the United Kingdom,Paris,Toronto,Sydney等.

  1. Le Pen õigustas natside tegevust Prantsusmaal / Margo Pajuste

    Index Scriptorium Estoniae

    Pajuste, Margo

    2005-01-01

    Prantsuse paremäärmusliku partei juht Jean-Marie Le Pen väitis, et Saksa okupatsioon II maailmasõja ajal Prantsusmaal ei olnud eriti ebainimlik ja et kui väited massimõrvade kohta Prantsusmaal vastaksid tõele, poleks olnud vaja luua koonduslaagreid poliitvangidele. Reageeringutest Le Peni väidete kohta Prantsusmaal

  2. Pen-based Interfaces for Engineering and Education

    Science.gov (United States)

    Stahovich, Thomas F.

    Sketches are an important problem-solving tool in many fields. This is particularly true of engineering design, where sketches facilitate creativity by providing an efficient medium for expressing ideas. However, despite the importance of sketches in engineering practice, current engineering software still relies on traditional mouse and keyboard interfaces, with little or no capabilities to handle free-form sketch input. With recent advances in machine-interpretation techniques, it is now becoming possible to create practical interpretation-based interfaces for such software. In this chapter, we report on our efforts to create interpretation techniques to enable pen-based engineering applications. We describe work on two fundamental sketch understanding problems. The first is sketch parsing, the task of clustering pen strokes or geometric primitives into individual symbols. The second is symbol recognition, the task of classifying symbols once they have been located by a parser. We have used the techniques that we have developed to construct several pen-based engineering analysis tools. These are used here as examples to illustrate our methods. We have also begun to use our techniques to create pen-based tutoring systems that scaffold students in solving problems in the same way they would ordinarily solve them with paper and pencil. The chapter concludes with a brief discussion of these systems.

  3. Novel dip-pen nanolithography strategies for nanopatterning

    NARCIS (Netherlands)

    Wu, Chien-Ching

    2010-01-01

    Dip-pen nanolithography (DPN) is an atomic force microscopy (AFM)-based lithography technique offering the possibility of fabricating patterns with feature sizes ranging from micrometers to tens of nanometers, utilizing either top-down or bottom-up strategies. Although during its early development s

  4. Development of a 3-D Pen Input Device

    Science.gov (United States)

    2008-09-01

    other form of eLearning portal. However with a pen-type input device, the professors are saved the trouble of either rewriting their notes or copying...and scanning the notes then uploading them into a form of eLearning , then broadcasting them for the distance learning students. Instead, the

  5. 9 CFR 313.1 - Livestock pens, driveways and ramps.

    Science.gov (United States)

    2010-01-01

    ... animal may be injured shall be repaired. (b) Floors of livestock pens, ramps, and driveways shall be constructed and maintained so as to provide good footing for livestock. Slip resistant or waffled floor... the opinion of the inspector, to protect them from the adverse climatic conditions of the locale...

  6. Applied Geophysics in the world of tomorrow - Microfabrication arrives

    Science.gov (United States)

    Johnson, R. M.

    2012-12-01

    Instrument manufacturers have a unique perspective on the design and use of geophysical equipment. The field instrument must provide reliable and repeatable performance in every climate condition and environmental extreme. The gear must be easy to use and more importantly easy to understand for non-native English speakers. I have traveled the world installing, repairing, commissioning and demonstrating geophysical survey systems. Everywhere I have traveled there is one unassailable fact - our geophysicist compatriots in developed and developing countries are hungry for information and hungry for technology. They want more and better systems to help improve their understanding of the subsurface. And they want to serve their countries by helping to exploit natural resources. I hold up for your review the first highly successful portable magnetometer, the G-856. Designed in 1981 with over 5000 sold, it is still produced in record numbers today for use all over the world. How could it be that a rather simple device could be so long lived, and make such an impact in exploration programs for 32 years? The answer is in producing reliable and easy to use equipment that is affordable. One might compare it to the iPad or Android device of today. The innovative and no-frills interface has attracted users from all markets including mining, oil/gas, archaeology, environmental, UXO/military and forensics. Powerful ancillary software to process the data has always been included at no charge, offering geoscientists a solution rather than a black box. Many of our technologies are poised for dramatic breakthroughs in miniaturization and interconnectivity. I point specifically to the micro-fabrication of the cesium vapor magnetometer. Initiated 5 years ago in conjunction with NIST, Geometrics has embarked on a high stakes game of minimizing size, weight, power consumption and price while eliminating dead zones and maintaining or increasing sensitivity and sample speed. These new

  7. Economic evaluation of the administration of follitropin-beta with a pen device.

    NARCIS (Netherlands)

    Bruynesteyn, K.; Bonsel, G.J.; Braat, D.D.M.; Fauser, B.C.J.M.; Devroey, P.; Genugten, M.L.L van

    2005-01-01

    Previous studies suggest that administration of follitropin-beta with a pen device (Puregon Pen(R)) is more convenient, less painful and 16-18% more efficient. The aim of this study was to perform an economic evaluation of the administration of follitropin-beta by this pen device against follitropin

  8. Possible contamination with clenbuterol from treated veal calves to untreated pen mates

    NARCIS (Netherlands)

    Groot, M.J.; Lasaroms, J.J.P.; Bennekom, van E.O.; Hende, van J.; Nielen, M.W.F.

    2013-01-01

    To investigate whether clenbuterol-treated calves could contaminate untreated pen mates, three animal experiments were performed. (1) One calf of a pen of five was treated with clenbuterol by injection (Ventipulmin injection, REG NL 2532, 2.5 mL/100 kg) twice a day for 10 days. (2) In two pens, one

  9. Economic evaluation of the administration of follitropin-beta with a pen device.

    NARCIS (Netherlands)

    Bruynesteyn, K.; Bonsel, G.J.; Braat, D.D.M.; Fauser, B.C.J.M.; Devroey, P.; Genugten, M.L.L van

    2005-01-01

    Previous studies suggest that administration of follitropin-beta with a pen device (Puregon Pen(R)) is more convenient, less painful and 16-18% more efficient. The aim of this study was to perform an economic evaluation of the administration of follitropin-beta by this pen device against follitropin

  10. Drag coefficient and plant form response to wind speed in three plant species: Burning Bush (Euonymus alatus), Colorado Blue Spruce (Picea pungens glauca.), and Fountain Grass (Pennisetum setaceum)

    Science.gov (United States)

    Gillies, J. A.; Nickling, W. G.; King, J.

    2002-12-01

    Whole-plant drag coefficients (Cd) for three plant species: Burning Bush (Euonymus alatus), Colorado Blue Spruce (Picea pungens glauca.), and Fountain Grass (Pennisetum setaceum) in five different porosity configurations were developed from force versus wind speed data collected with a force balance in a recirculating wind tunnel. The average Cd for the Burning Bush, Colorado Spruce, and Fountain Grass in their untrimmed forms were 0.42 (±0.03), 0.39 (±0.04), and 0.34 (±0.06), respectively. Drag curves (Cd versus flow Reynolds number (Re) function) for the Burning Bush and Colorado Spruce were found to exhibit, for the lower porosity configurations, a rise to a maximum around flow Reynolds numbers (Re = ρuhh/ν) of 2 × 105. Fountain Grass Cd was shown to be dependent upon Re to values >5 × 105. The Burning Bush and Colorado Spruce plants reduced their drag, upon reaching their maxima, by decreasing their frontal area and increasing their porosity. Maximum Cd for these plants occurred at optical porosities of ˜0.20. The Fountain Grass reduced drag at high Re by decreasing frontal area and porosity. The mechanism of drag reduction in Fountain Grass was continual reconfiguration to a more aerodynamic form as evidenced by continual reduction of Cd with Re.

  11. Modified Penning-Malmberg Trap for Storing Antiprotons

    Science.gov (United States)

    Sims, William H.; Martin, James; Lewis, Raymond

    2005-01-01

    A modified Penning-Malmberg trap that could store a small cloud of antiprotons for a relatively long time (weeks) has been developed. This trap is intended for use in research on the feasibility of contemplated future matter/antimatter-annihilation systems as propulsion sources for spacecraft on long missions. This trap is also of interest in its own right as a means of storing and manipulating antiprotons for terrestrial scientific experimentation. The use of Penning-Malmberg traps to store antiprotons is not new. What is new here is the modified trap design, which utilizes state-of-the-art radiofrequency (RF) techniques, including ones that, heretofore, have been used in radio-communication applications but not in iontrap applications. A basic Penning-Malmberg trap includes an evacuated round tube that contains or is surrounded by three or more collinear tube electrodes. A steady axial magnetic field that reaches a maximum at the geometric center of the tube is applied by an external source, and DC bias voltages that give rise to an electrostatic potential that reaches a minimum at the center are applied to the electrodes. The combination of electric and magnetic fields confines the charged particles (ions or electrons) for which it was designed to a prolate spheroidal central region. However, geometric misalignments and the diffusive cooling process prevent the steady fields of a basic Penning- Malmberg trap from confining the particles indefinitely. In the modified Penning-Malmberg trap, the loss of antiprotons is reduced or eliminated by use of a "rotating-wall" RF stabilization scheme that also heats the antiproton cloud to minimize loss by matter/antimatter annihilation. The scheme involves the superposition of a quadrupole electric field that rotates about the cylindrical axis at a suitably chosen radio frequency. The modified Penning-Malmberg trap (see Figure 1) includes several collinear sets of electrodes inside a tubular vacuum chamber. Each set

  12. THE FIRST ''WATER FOUNTAIN'' COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    Energy Technology Data Exchange (ETDEWEB)

    Gómez, José F.; Miranda, Luis F.; Guerrero, Martín A. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Suárez, Olga; Bendjoya, Philippe; Lagadec, Eric [Laboratoire Lagrange, UMR 7293, Université de Nice Sophia-Antipolis, CNRS, Observatoire de la Côte d' Azur, F-06304 Nice (France); Rizzo, J. Ricardo; García-García, Enrique [Centro de Astrobiología (INTA-CSIC), Ctra. M-108, km. 4, E-28850 Torrejón de Ardoz (Spain); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, P.O. Box 76, Epping, NSW 1710 (Australia); Uscanga, Lucero [Institute of Astronomy, Astrophysics, Space Applications and Remote Sensing, National Observatory of Athens, 15236 Athens (Greece); Ramos-Larios, Gerardo [Instituto de Astronomía y Meteorología, Av. Vallarta No. 2602, Col. Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco (Mexico)

    2015-02-01

    ''Water fountains'' (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s{sup –1}) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a ''Hubble-like'' flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase.

  13. The absorption and emission spectrum of radiative cooling galactic fountain gas

    Science.gov (United States)

    Benjamin, Robert A.; Shapiro, Paul R.

    1993-01-01

    We have calculated the time-dependent, nonequilibrium thermal and ionization history of gas cooling radiatively from 10(exp 6) K in a one-dimensional, planar, steady-state flow model of the galactic fountain, including the effects of radiative transfer. Our previous optically thin calculations explored the effects of photoionization on such a flow and demonstrated that self-ionization was sufficient to cause the flow to match the observed galactic halo column densities of C 4, Si 4, and N 5 and UV emission from C 4 and O 3 in the constant density (isochoric) limit, which corresponded to cooling regions homogeneous on scales D less than or approximately equal to 1 kpc. Our new calculations which take full account of radiative transfer confirm the importance of self-ionization in enabling such a flow to match the data but allow a much larger range for cooling region sizes, i.e. D(sub 0) greater than or approximately equal to 15 pc. For an initial flow velocity v(sub 0) approximately equal to 100 km/s, comparable to the sound speed of a 10(exp 6) K gas, the initial density is found to be n(sub h,0) is approximately 2 x 10(exp -2) cm(exp -3), in reasonable agreement with other observation estimates, and D(sub 0) is approximately equal to 40 pc. We also compare predicted H(alpha) fluxes, UV line emission, and broadband x-ray fluxes with observed values. One dimensional numerical hydrodynamical calculations including the effects of radiative cooling are also presented.

  14. Key points of safety design of electrical installation of fountains%喷水池电气安全设计要点

    Institute of Scientific and Technical Information of China (English)

    洪元颐; 卢子涛; 逄京

    2000-01-01

    喷水池的电气安全是一个十分重要的问题。特别是在发生了因喷水池漏电造成数名儿童电击致死的惨痛事故之后,更引起了各方的关注。为了便于电气专业设计人员参照,特编制本要点。%Safety of electrical installation is very important for water fountains.The misery which caused losses of some children?lives because of leakage of fountain electrical equipment has aroused concerns from many parties.The key points on safety design of electrical installation of fountains are compiled for designers?reference.

  15. A Brief Presentation of Lanzhou Penning Trap Control System

    Institute of Scientific and Technical Information of China (English)

    田玉林; 黄文学; 王均英; 孙宇梁; 王玥; 朱志超; 赵建民; 徐瑚珊; 肖国青

    2012-01-01

    LPT (Lanzhou Penning Trap) is an ion-trap facility in Lanzhou, China. As ions can be cooled to an extremely small phase space and can be stored for a very long time, ion traps are a perfect instrument for high precision mass measurements. A system with specialized electronics for LPT is under construction now. This system could be used for voltage and timing control to make ions moving in a special mode, and the data acquisition and analysis online/offline could be achieved in the mean time. The requirements of control system, the distribution of hardware, the overview of software, and the latest progress of LPTCtrlSys (Lanzhou Penning Trap Control System) are presented.

  16. Recent developments in Penning-trap mass spectrometry

    Science.gov (United States)

    Block, M.

    2016-06-01

    Penning-trap mass spectrometry provides atomic masses with the highest precision. At accelerator-based on-line facilities it is applied to investigate exotic radionuclides in the context of tests of fundamental symmetries, nuclear structure studies, and nuclear astrophysics research. Recent progress in slowing down radioactive ion-beams in buffer-gas cells in combination with advanced ion-manipulation techniques has paved the way to reach nuclides ever-more far from stability. In this endeavor many efforts are underway to increase the sensitivity, the efficiency, and the precision of Penning-trap mass spectrometry. In this article some recent experimental developments are addressed with the focus on the phase-imaging ion-cyclotron-resonance technique and the Fourier transform ion-cyclotron-resonance technique.

  17. Penning ionization of doped helium nanodroplets following EUV excitation

    CERN Document Server

    Buchta, D; Brauer, N B; Drabbels, M; O'Keeffe, P; Devetta, M; DiFraia, M; Callegari, C; Richter, R; Coreno, M; Prince, K; Stienkemeier, F; Moshammer, R; Mudrich, M

    2013-01-01

    Helium nanodroplets are widely used as a cold, weakly interacting matrix for spectroscopy of embedded species. In this work we excite or ionize doped He droplets using synchrotron radiation and study the effect onto the dopant atoms depending on their location inside the droplets (rare gases) or outside at the droplet surface (alkali metals). Using photoelectron-photoion coincidence imaging spectroscopy at variable photon energies (20-25 eV), we compare the rates of charge-transfer to Penning ionization of the dopants in the two cases. The surprising finding is that alkali metals, in contrast to the rare gases, are efficiently Penning ionized upon excitation of the (n=2)-bands of the host droplets. This indicates rapid migration of the excitation to the droplet surface, followed by relaxation, and eventually energy transfer to the alkali dopants.

  18. Lorentz-violating spinor electrodynamics and Penning traps

    Science.gov (United States)

    Ding, Yunhua; Kostelecký, V. Alan

    2016-09-01

    The prospects are explored for testing Lorentz- and C P T -violating quantum electrodynamics in experiments with Penning traps. We present the Lagrange density of Lorentz-violating spinor electrodynamics with operators of mass dimensions up to 6, and we discuss some of its properties. The theory is used to derive Lorentz- and C P T -violating perturbative shifts of the energy levels of a particle confined to a Penning trap. Observable signals are discussed for trapped electrons, positrons, protons, and antiprotons. Existing experimental measurements on anomaly frequencies are used to extract new or improved bounds on numerous coefficients for Lorentz and C P T violation, using sidereal variations of observables and comparisons between particles and antiparticles.

  19. Translocation techniques used to establish pen farmed Alaskan reindeer

    Directory of Open Access Journals (Sweden)

    R. A. Dieterich

    1990-09-01

    Full Text Available Small herds of reindeer (Rangifer tarandus frequently have been needed to be established in fenced holding pens for research or commercial reasons in Alaska and other areas. Native ranges of reindeer in Alaska were not on road systems, and the diet of the native reindeer had to be changed when they were translocated to small pens. Economics of transportation and feeding played an important role in the feasibility of translocation. Gathering and holding of reindeer for shipment, transport methods, adjustment of free-ranging reindeer to confinement, and a new diet were primary considerations to insure survival. Minimal psychologic stress of short duration, thermoregulation, and physical comfort were extremely important in carrying out a successful translocation. Receiving facilities, feed, and personnel were equally important. A minimum of one month was required to adjust reindeer to confinement and diet change.

  20. Non-linear PIC simulation in a penning trap

    Energy Technology Data Exchange (ETDEWEB)

    Delzanno, G. L. (Gian L.); Lapenta, G. M. (Giovanni M.); Finn, J. M. (John M.)

    2001-01-01

    We study the non-linear dynamics of a Penning trap plasma, including the effect of the finite length and end curvature of the plasma column. A new cylindrical PIC code, called KANDINSKY, has been implemented by using a new interpolation scheme. The principal idea is to calculate the volume of each cell from a particle volume, in the same manner as it is done for the cell charge. With this new method, the density is conserved along streamlines and artificial sources of compressibility are avoided. The code has been validated with a reference Eulerian fluid code. We compare the dynamics of three different models: a model with compression effects, the standard Euler model and a geophysical fluid dynamics model. The results of our investigation prove that Penning traps can really be used to simulate geophysical fluids.

  1. Determining isotopic distributions of fission products with a penning trap

    Energy Technology Data Exchange (ETDEWEB)

    Penttilae, H.; Karvonen, P.; Eronen, T.; Elomaa, V.V.; Hager, U.; Hakala, J.; Jokinen, A.; Kankainen, A.; Moore, I.D.; Peraejaervi, K.; Rahaman, S.; Rinta-Antila, S.; Saastamoinen, A.; Sonoda, T.; Aeystoe, J. [University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland); Rubchenya, V. [University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland); V.G. Khlopin Radium Institute, St. Petersburg (Russian Federation)

    2010-04-15

    A novel method to determine independent yields in particle-induced fission employing the ion guide technique and ion counting after a Penning trap has been developed. The method takes advantage of the fact that a Penning trap can be used as a precision mass filter, which allows an unambiguous identification of the fission fragments. The method was tested with 25MeV and 50MeV proton-induced fission of {sup 238}U. The data is internally reproducible with an accuracy of a few per cent. A satisfactory agreement was obtained with older ion guide yield measurements in 25MeV proton-induced fission. The results for Rb and Cs yields in 50MeV proton-induced fission agree with previous measurements performed at an isotope separator equipped with a chemically selective ion source. (orig.)

  2. Thermoplastic polymers surfaces for Dip-Pen Nanolithography of oligonucleotides

    Energy Technology Data Exchange (ETDEWEB)

    Suriano, Raffaella [Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Biella, Serena, E-mail: serena.biella@polimi.it [Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Cesura, Federico; Levi, Marinella; Turri, Stefano [Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2013-05-15

    Different thermoplastic polymers were spin-coated to prepare smooth surfaces for the direct deposition of end-group modified oligonucleotides by Dip-Pen Nanolithography. A study of the diffusion process was done in order to investigate the dependence of calibration coefficient and quality of deposited features on environmental parameters (temperature, relative humidity) and ink's molecular weight and functionality. The optimization of the process parameters led to the realization of high quality and density nanoarrays on plastics.

  3. Mass measurements with a Penning trap mass spectrometer at ISOLDE

    CERN Document Server

    Bollen, G; Audi, G; Beck, D; Herfurth, F; Kluge, H J; Kohl, A; Lunney, M D; Moore, R B; De Saint-Simon, M; Schark, E; Schwarz, S; Szerypo, J

    1998-01-01

    Penning trap mass measurements on radioactive isotopes are performed with the ISOLTRAP mass spectrometer at ISOLDE/CERN. In the last years the applicability of the spectrometer has been considerably extended. The most recent measurements were carried out on isotopes of rare earth elements and on isotopes with Z=80-85. An accuracy of $\\delta$ m/m approximately=1$\\cdot$10$^{-7}$was achieved. (19 refs).

  4. Tako-tsubo-like cardiomyopathy after EpiPen administration.

    Science.gov (United States)

    Zubrinich, C M; Farouque, H M Omar; Rochford, S E; Sutherland, M F

    2008-11-01

    Tako-tsubo-like cardiomyopathy is characterized by acute chest pain, electrocardiographic changes and increased cardiac enzymes in the absence of obstructive coronary vessel disease. We describe the development of tako-tsubo-like cardiomyopathy in an elderly woman after the use of an EpiPen for generalized urticaria and angioedema. As adrenaline may participate in the pathogenesis of this condition, the need for careful patient selection and education in the use of adrenaline self-injectors remains imperative.

  5. The EpiPen and the ischaemic finger.

    Science.gov (United States)

    Singh, Talvinder; Randhawa, Susheelwant; Khanna, Rakesh

    2007-08-01

    We present a case of a 24-year-old with a history of accidental injection of adrenaline from an EpiPen into the proximal aspect of her left index finger. Various methods were advocated to treat digital ischaemia but were of no benefit. Topical infiltration of phentolamine in 1 ml of lignocaine 2% was given at the puncture site with immediate results of resolution of digital ischaemia.

  6. Micro-fabricated integrated coil and magnetic circuit and method of manufacturing thereof

    Energy Technology Data Exchange (ETDEWEB)

    Mihailovich, Robert E.; Papavasiliou, Alex P.; Mehrotra, Vivek; Stupar, Philip A.; Borwick, III, Robert L.; Ganguli, Rahul; DeNatale, Jeffrey F.

    2017-03-28

    A micro-fabricated electromagnetic device is provided for on-circuit integration. The electromagnetic device includes a core. The core has a plurality of electrically insulating layers positioned alternatingly between a plurality of magnetic layers to collectively form a continuous laminate having alternating magnetic and electrically insulating layers. The electromagnetic device includes a coil embedded in openings of the semiconductor substrate. An insulating material is positioned in the cavity and between the coil and an inner surface of the core. A method of manufacturing the electromagnetic device includes providing a semiconductor substrate having openings formed therein. Windings of a coil are electroplated and embedded in the openings. The insulating material is coated on or around an exposed surface of the coil. Alternating magnetic layers and electrically insulating layers may be micro-fabricated and electroplated as a single and substantially continuous segment on or around the insulating material.

  7. Micro-fabricated integrated coil and magnetic circuit and method of manufacturing thereof

    Science.gov (United States)

    Mihailovich, Robert E.; Papavasiliou, Alex P.; Mehrotra, Vivek; Stupar, Philip A.; Borwick, III, Robert L.; Ganguli, Rahul; DeNatale, Jeffrey F.

    2017-03-28

    A micro-fabricated electromagnetic device is provided for on-circuit integration. The electromagnetic device includes a core. The core has a plurality of electrically insulating layers positioned alternatingly between a plurality of magnetic layers to collectively form a continuous laminate having alternating magnetic and electrically insulating layers. The electromagnetic device includes a coil embedded in openings of the semiconductor substrate. An insulating material is positioned in the cavity and between the coil and an inner surface of the core. A method of manufacturing the electromagnetic device includes providing a semiconductor substrate having openings formed therein. Windings of a coil are electroplated and embedded in the openings. The insulating material is coated on or around an exposed surface of the coil. Alternating magnetic layers and electrically insulating layers may be micro-fabricated and electroplated as a single and substantially continuous segment on or around the insulating material.

  8. Morphology and size dependence of silver microstructures in fatty salts-assisted multiphoton photoreduction microfabrication

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Yao-Yu.; Dong, Xian-Zi [Chinese Academy of Sciences, Laboratory of Organic NanoPhotonics and Key Laboratory of Photochemical Conversion and Functional Materials, Technical Institute of Physics and Chemistry, Beijing (China); Graduate School of the Chinese Academy of Sciences, Beijing (China); Takeyasu, Nobuyuki [RIKEN (Institute of Physical and Chemical Research), Nanophotonics Laboratory, Wako, Saitama (Japan); Tanaka, Takuo [RIKEN (Institute of Physical and Chemical Research), Metamaterials Laboratory, Wako, Saitama (Japan); Zhao, Zhen-Sheng; Duan, Xuan-Ming [Chinese Academy of Sciences, Laboratory of Organic NanoPhotonics and Key Laboratory of Photochemical Conversion and Functional Materials, Technical Institute of Physics and Chemistry, Beijing (China); Kawata, Satoshi [RIKEN (Institute of Physical and Chemical Research), Nanophotonics Laboratory, Wako, Saitama (Japan); Osaka University, Department of Applied Physics, Graduate School of Engineering, Suita, Osaka (Japan)

    2009-08-15

    The morphology and size dependence of silver microstructures in a novel microfabrication process, fatty salts-assisted multiphoton photoreduction (MPR), were investigated by using the fatty salts with different carbon chain lengths (C{sub n}:n=4,5,7,9) under varied powers and irradiation times of a femtosecond near-infrared laser with the wavelength of 800 nm. Not only the feature size of the silver structures was reduced but also the surface smoothness was improved by increasing the chain length of the fatty salts. The highest resolution of a silver line was obtained to be 285 nm, which exceeded the diffraction limit. The fatty salts-assisted MPR microfabrication approach would provide an efficient protocol for fabricating metallic micro/nanostructures with fine morphology and size and could play an important role in the fabrication of the metallic micro/nanostructures for applications in photonics and electronics as well as in sensors. (orig.)

  9. Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.

    Science.gov (United States)

    Nerger, Bryan A; Siedlik, Michael J; Nelson, Celeste M

    2017-05-01

    Cell-generated forces drive an array of biological processes ranging from wound healing to tumor metastasis. Whereas experimental techniques such as traction force microscopy are capable of quantifying traction forces in multidimensional systems, the physical mechanisms by which these forces induce changes in tissue form remain to be elucidated. Understanding these mechanisms will ultimately require techniques that are capable of quantifying traction forces with high precision and accuracy in vivo or in systems that recapitulate in vivo conditions, such as microfabricated tissues and engineered substrata. To that end, here we review the fundamentals of traction forces, their quantification, and the use of microfabricated tissues designed to study these forces during cell migration and tissue morphogenesis. We emphasize the differences between traction forces in two- and three-dimensional systems, and highlight recently developed techniques for quantifying traction forces.

  10. Controlling trapping potentials and stray electric fields in a microfabricated ion trap through design and compensation

    CERN Document Server

    Doret, S Charles; Wright, Kenneth; Volin, Curtis; Killian, Tyler; Ozakin, Arkadas; Denison, Douglas; Hayden, Harley; Pai, C -S; Slusher, Richart E; Harter, Alexa W

    2012-01-01

    Recent advances in quantum information processing with trapped ions have demonstrated the need for new ion trap architectures capable of holding and manipulating chains of many (>10) ions. Here we present the design and detailed characterization of a new linear trap, microfabricated with scalable complementary metal-oxide-semiconductor (CMOS) techniques, that is well-suited to this challenge. Forty-four individually controlled DC electrodes provide the many degrees of freedom required to construct anharmonic potential wells, shuttle ions, merge and split ion chains, precisely tune secular mode frequencies, and adjust the orientation of trap axes. Microfabricated capacitors on DC electrodes suppress radio-frequency pickup and excess micromotion, while a top-level ground layer simplifies modeling of electric fields and protects trap structures underneath. A localized aperture in the substrate provides access to the trapping region from an oven below, permitting deterministic loading of particular isotopic/eleme...

  11. Pen rearing and imprinting of fall Chinook salmon

    Science.gov (United States)

    Beeman, J.W.; Novotny, J.F.

    1994-01-01

    Results of rearing upriver bright fall chinook salmon juveniles in net pens and a barrier net enclosure in two backwater areas and a pond along the Columbia River were compared with traditional hatchery methods. Growth, smoltification, and general condition of pen-reared fish receiving supplemental feeding were better than those of fish reared using traditional methods. Juvenile fish receiving no supplemental feeding were generally in poor condition resulting in a net loss of production. Rearing costs using pens were generally lower than in the hatchery. However, low adult returns resulted in greater cost per adult recovery than fish reared and released using traditional methods. Much of the differences in recovery rates may have been due to differences in rearing locations, as study sites were as much as 128 mi upstream from the hatcheries and study fish may have incurred higher mortality associated with downstream migration than control fish. Fish reared using these methods could be a cost-effective method of enhancing salmon production in the Columbia River Basin.

  12. Pen harvester for powering a pulse rate sensor

    Energy Technology Data Exchange (ETDEWEB)

    Bedekar, Vishwas [Department of Materials Science and Engineering, UT Arlington, TX 76019 (United States); Oliver, Josiah; Priya, Shashank [CEHMS, Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA 24060 (United States)], E-mail: spriya@mse.vt.edu

    2009-05-21

    Rapid developments in the area of micro-sensors for various applications such as structural health monitoring, bio-chemical sensors and pressure sensors have increased the demand for portable, low cost, high efficiency energy harvesting devices. In this paper, we describe the scheme for powering a pulse rate sensor with a vibration energy harvester integrated inside a pen commonly carried by humans in the pocket close to the heart. Electromagnetic energy harvesting was selected in order to achieve high power at lower frequencies. The prototype pen harvester was found to generate 3 mW at 5 Hz and 1 mW at 3.5 Hz operating under displacement amplitude of 16 mm (corresponding to an acceleration of approximately 1.14 g{sub rms} at 5 Hz and 0.56 g{sub rms} at 3.5 Hz, respectively). A comprehensive mathematical modelling and simulations were performed in order to optimize the performance of the vibration energy harvester. The integrated pen harvester prototype was found to generate continuous power of 0.46-0.66 mW under normal human actions such as jogging and jumping which is enough for a small scale pulse rate sensor.

  13. Pen Branch Delta and Savannah River Swamp Hydraulic Model

    Energy Technology Data Exchange (ETDEWEB)

    Chen, K.F.

    1999-05-13

    The proposed Savannah River Site (SRS) Wetlands Restoration Project area is located in Barnwell County, South Carolina on the southwestern boundary of the SRS Reservation. The swamp covers about 40.5 km2 and is bounded to the west and south by the Savannah River and to the north and east by low bluffs at the edge of the Savannah River floodplain. Water levels within the swamp are determined by stage along the Savannah River, local drainage, groundwater seepage, and inflows from four tributaries, Beaver Dam Creek, Fourmile Branch, Pen Branch, and Steel Creek. Historic discharges of heated process water into these tributaries scoured the streambed, created deltas in the adjacent wetland, and killed native vegetation in the vicinity of the delta deposits. Future releases from these tributaries will be substantially smaller and closer to ambient temperatures. One component of the proposed restoration project will be to reestablish indigenous wetland vegetation on the Pen Branch delta that covers about 1.0 km2. Long-term predictions of water levels within the swamp are required to determine the characteristics of suitable plants. The objective of the study was to predict water levels at various locations within the proposed SRS Wetlands Restoration Project area for a range of Savannah River flows and regulated releases from Pen Branch. TABS-MD, a United States Army Corps of Engineer developed two-dimensional finite element open channel hydraulic computer code, was used to model the SRS swamp area for various flow conditions.

  14. A Two- Photon Femtosecond Laser System for Three-Dimensional Microfabrication and Data Storage

    Institute of Scientific and Technical Information of China (English)

    蒋中伟; 周拥军; 袁大军; 黄文浩; 夏安东

    2003-01-01

    Utilizing the well-focused femtosecond laser with extreme high pulse intensity, we built a two-photon microfabrication and data storage system, which was introduced through several functional parts. Based on this homemade system, several three-dimensional microstructures were fabricated by two-photon polymerization, and three-dimensional data storage of six-layers was achieved by two-photon excitation with a photochromic material.

  15. Design, Microfabrication and Characterization of a Power Delivery System for new Biomedical Applications

    Directory of Open Access Journals (Sweden)

    CARUSO Massimo

    2017-05-01

    Full Text Available This paper presents the design, microfabrication and characterization of a wireless power delivery system capable of driving a surface acoustic wave sensor (SAW for biomedical applications. The system consists of two planar, spiral-square microcoils, which have been geometrically optimized in order to maximize the quality factor Q. The integration of the SAW - microcoil system into artificial implant sites will allow a real-time biofilm growth monitoring and treatment, providing countless advantages to the related medical applications.

  16. UV-LIGA Microfabrication of 220 GHz Sheet Beam Amplifier Gratings with SU-8 Photoresists

    Science.gov (United States)

    2010-01-01

    transconductance amplifier was built to handle the needs of a large-scale (25 l bath) copper electroforming system presently under construction...UV-LIGA microfabrication of 220 GHz sheet beam amplifier gratings with SU-8 photoresists This article has been downloaded from IOPscience. Please...burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA

  17. A System for Trapping Barium Ions in a Microfabricated Surface Trap

    CERN Document Server

    Graham, Richard D; Sakrejda, Tomasz; Wright, John; Zhou, Zichao; Blinov, Boris B

    2013-01-01

    We have developed a vacuum chamber and control system for rapid testing of microfabricated surface ion traps. Our system uses a modular design and is based on an in-vacuum PCB with integrated filters. We have used this system to successfully trap and cool barium ions. We have demonstrated ion 'dark' lifetimes of 31.6 s +- 3.4 s and controlled shuttling of ions using a custom 96 electrode control system with an update rate of 40 kHz.

  18. Microfabricated inserts for magic angle coil spinning (MACS wireless NMR spectroscopy.

    Directory of Open Access Journals (Sweden)

    Vlad Badilita

    Full Text Available This article describes the development and testing of the first automatically microfabricated probes to be used in conjunction with the magic angle coil spinning (MACS NMR technique. NMR spectroscopy is a versatile technique for a large range of applications, but its intrinsically low sensitivity poses significant difficulties in analyzing mass- and volume-limited samples. The combination of microfabrication technology and MACS addresses several well-known NMR issues in a concerted manner for the first time: (i reproducible wafer-scale fabrication of the first-in-kind on-chip LC microresonator for inductive coupling of the NMR signal and reliable exploitation of MACS capabilities; (ii improving the sensitivity and the spectral resolution by simultaneous spinning the detection microcoil together with the sample at the "magic angle" of 54.74° with respect to the direction of the magnetic field (magic angle spinning - MAS, accompanied by the wireless signal transmission between the microcoil and the primary circuit of the NMR spectrometer; (iii given the high spinning rates (tens of kHz involved in the MAS methodology, the microfabricated inserts exhibit a clear kinematic advantage over their previously demonstrated counterparts due to the inherent capability to produce small radius cylindrical geometries, thus tremendously reducing the mechanical stress and tearing forces on the sample. In order to demonstrate the versatility of the microfabrication technology, we have designed MACS probes for various Larmor frequencies (194, 500 and 700 MHz testing several samples such as water, Drosophila pupae, adamantane solid and LiCl at different magic angle spinning speeds.

  19. Direct visualization of clay microfabric signatures driving organic matter preservation in fine-grained sediment

    Science.gov (United States)

    Curry, Kenneth J.; Bennett, Richard H.; Mayer, Lawrence M.; Curry, Ann; Abril, Maritza; Biesiot, Patricia M.; Hulbert, Matthew H.

    2007-04-01

    We employed direct visualization of organic matter (OM) sequestered by microfabric signatures in organo-clay systems to study mechanisms of OM protection. We studied polysaccharides, an abundant class of OM in marine sediments, associated with the nano- and microfabric of clay sediment using a novel application of transmission electron microscopy, histochemical staining (periodic acid-thiosemicarbazide-silver proteinate), and enzymatic digestion techniques. We used two experimental organo-clay sediment environments. First, laboratory-consolidated sediment with 10% chitin (w/w) added was probed for chitin before and after digestion with chitinase. Second, fecal pellets from the polychaete Heteromastus filiformis were used as a natural environment rich in clay and polysaccharides. Sections of this material were probed with silver proteinate for polysaccharides before and after digestion with a mixture of enzymes (amylase, cellulase, chitinase, dextranase, and pectinase). In both environments, chitin or other polysaccharides were found within pores, bridging clay domains, and attached to clay surfaces in undigested samples. Digested samples showed chitin or polysaccharides more closely associated with clay surfaces and in small pores. Our results imply protective roles for both sorption to clay surfaces and encapsulation within clay microfabric signatures.

  20. Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues.

    Science.gov (United States)

    Ramade, Alexandre; Legant, Wesley R; Picart, Catherine; Chen, Christopher S; Boudou, Thomas

    2014-01-01

    Engineered tissues can be used to understand fundamental features of biology, develop organotypic in vitro model systems, and as engineered tissue constructs for replacing damaged tissue in vivo. However, a key limitation is an inability to test the wide range of parameters that might impact the engineered tissue in a high-throughput manner and in an environment that mimics the three-dimensional (3D) native architecture. We developed a microfabricated platform to generate arrays of microtissues embedded within 3D micropatterned matrices. Microcantilevers simultaneously constrain microtissue formation and report forces generated by the microtissues in real time, opening the possibility to use high-throughput, low-volume screening for studies on engineered tissues. Thanks to the micrometer scale of the microtissues, this platform is also suitable for high-throughput monitoring of drug-induced effect on architecture and contractility in engineered tissues. Moreover, independent variations of the mechanical stiffness of the cantilevers and collagen matrix allow the measurement and manipulation of the mechanics of the microtissues. Thus, our approach will likely provide valuable opportunities to elucidate how biomechanical, electrical, biochemical, and genetic/epigenetic cues modulate the formation and maturation of 3D engineered tissues. In this chapter, we describe the microfabrication, preparation, and experimental use of such microfabricated tissue gauges.

  1. Microfabricated BTU monitoring device for system-wide natural gas monitoring.

    Energy Technology Data Exchange (ETDEWEB)

    Einfeld, Wayne; Manginell, Ronald Paul; Robinson, Alex Lockwood; Moorman, Matthew Wallace

    2005-11-01

    The natural gas industry seeks inexpensive sensors and instrumentation to rapidly measure gas heating value in widely distributed locations. For gas pipelines, this will improve gas quality during transfer and blending, and will expedite accurate financial accounting. Industrial endusers will benefit through continuous feedback of physical gas properties to improve combustion efficiency during use. To meet this need, Sandia has developed a natural gas heating value monitoring instrument using existing and modified microfabricated components. The instrument consists of a silicon micro-fabricated gas chromatography column in conjunction with a catalytic micro-calorimeter sensor. A reference thermal conductivity sensor provides diagnostics and surety. This combination allows for continuous calorimetric determination with a 1 minute analysis time and 1.5 minute cycle time using air as a carrier gas. This system will find application at remote natural gas mining stations, pipeline switching and metering stations, turbine generators, and other industrial user sites. Microfabrication techniques will allow the analytical components to be manufactured in production quantities at a low per-unit cost.

  2. Effect of calcium hydroxide application to cattle feedlot pens on Escherichia coli O157:H7 and total E. coli in pen surface manure

    Science.gov (United States)

    Introduction: Cattle and beef products are sources of the pathogen Escherichia coli O157:H7. Lime products have a long history of use in cattle production as disinfectants for sick pens, calving pens, and muddy areas, to control the spread of diseases. Lime may also be useful as a preharvest trea...

  3. Examining Factors That Impact Inpatient Management of Diabetes and the Role of Insulin Pen Devices.

    Science.gov (United States)

    Smallwood, Chelsea; Lamarche, Danièle; Chevrier, Annie

    2017-02-01

    Insulin administration in the acute care setting is an integral component of inpatient diabetes management. Although some institutions have moved to insulin pen devices, many acute care settings continue to employ the vial and syringe method of insulin administration. The aim of this study was to evaluate the impact of insulin pen implementation in the acute care setting on patients, healthcare workers and health resource utilization. A review of published literature, including guidelines, was conducted to identify how insulin pen devices in the acute care setting may impact inpatient diabetes management. Previously published studies have revealed that insulin pen devices have the potential to improve inpatient management through better glycemic control, increased adherence and improved self-management education. Furthermore, insulin pen devices may result in cost savings and improved safety for healthcare workers. There are benefits to the use of insulin pen devices in acute care and, as such, their implementation should be considered.

  4. Demonstration of the Double Penning Trap Technique with a Single Proton

    CERN Document Server

    Mooser, A; Franke, K.; Kracke, H.; Leiteritz, C.; Rodegheri, C.C.; Nagahama, H.; Schneider, G.; Smorra, C.; Blaum, K.; Matsuda, Y.; Quint, W.; Walz, J.; Yamazaki, Y.; Ulmer, S.; Yamazaki, Y; Ulmer, S

    2013-01-01

    Spin flips of a single proton were driven in a Penning trap with a homogeneous magnetic field. For the spin-state analysis the proton was transported into a second Penning trap with a superimposed magnetic bottle, and the continuous Stern-Gerlach effect was applied. This first demonstration of the double Penning trap technique with a single proton suggests that the antiproton magnetic moment measurement can potentially be improved by three orders of magnitude or more.

  5. Arsenic Removal from Drinking Water by Iron Removal - U.S. EPA Demonstration Project at Northeastern Elementary School in Fountain City, IN - Final Performance Evaluation Report

    Science.gov (United States)

    This report documents the activities performed and the results obtained from the arsenic removal treatment technology demonstration project at Northeastern Elementary School in Fountain City, IN. The main objective of the project was to evaluate the effectiveness of US Water Sys...

  6. An evaluation of exercise pen use by circus tigers (Pathera tigris tigris).

    Science.gov (United States)

    Nevill, Christian H; Friend, Ted H; Windom, Amy G

    2010-01-01

    This study quantified the behavior of 11 tigers during periodic access to an exercise pen throughout the day and night. The study determined the amount of time spent in the pen and the percentage of time spent performing stereotypic pacing, normal locomotor behavior, and lying down while in the pen. Average access to the exercise pen was 10 hr 49 min overnight and 5 hr 30 min during the day. At night, the tigers spent 29.1% of their time in the exercise pen, during which they paced 19.6% and performed normal locomotor behavior for 23.1% of that time. By day, they spent 40.4% of their time in the exercise pen, during which they paced 10.0% and performed normal locomotor behavior 35.7% of that time. The tigers spent the rest of the time in the pen lying down. Overall, tigers will utilize an exercise pen, spending a greater percentage of time in the pen during the day than at night and also performing less stereotyped pacing than at night.

  7. Experimental research on showing automatic disappearance pen handwriting based on spectral imaging technology

    Science.gov (United States)

    Su, Yi; Xu, Lei; Liu, Ningning; Huang, Wei; Xu, Xiaojing

    2016-10-01

    Purpose to find an efficient, non-destructive examining method for showing the disappearing words after writing with automatic disappearance pen. Method Using the imaging spectrometer to show the potential disappearance words on paper surface according to different properties of reflection absorbed by various substances in different bands. Results the disappeared words by using different disappearance pens to write on the same paper or the same disappearance pen to write on different papers, both can get good show results through the use of the spectral imaging examining methods. Conclusion Spectral imaging technology can show the disappearing words after writing by using the automatic disappearance pen.

  8. Analysis of the NovoTwist pen needle in comparison with conventional screw-thread needles.

    Science.gov (United States)

    Aye, Tandy

    2011-11-01

    Administration of insulin via a pen device may be advantageous over a vial and syringe system. Hofman and colleagues introduce a new insulin pen needle, the NovoTwist, to simplify injections to a small group of children and adolescents. Their overall preferences and evaluation of the handling of the needle are reported in the study. This new needle has the potential to ease administration of insulin via a pen device that may increase both the use of a pen device and adherence to insulin therapy.

  9. Squid Pen Chitin Chitooligomers as Food Colorants Absorbers

    OpenAIRE

    Tzu-Wen Liang; Chih-Ting Huang; Nguyen Anh Dzung; San-Lang Wang

    2015-01-01

    One of the most promising applications of chitosanase is the conversion of chitinous biowaste into bioactive chitooligomers (COS). TKU033 chitosanase was induced from squid pen powder (SPP)-containing Bacillus cereus TKU033 medium and purified by ammonium sulfate precipitation and column chromatography. The enzyme was relatively more thermostable in the presence of the substrate and had an activity of 93% at 50 °C in a pH 5 buffer solution for 60 min. Furthermore, the enzyme used for the COS ...

  10. Web Mining: Penning an Era of Information Age

    OpenAIRE

    Anshika Goel; Dinesh Sahu; Manish Kumar

    2014-01-01

    Today's age is rightly pronounced as "Information Age" which stands on the edifice of Information Technology and is operated by the Internet through the concept of web mining and is maintained & evolved through the high-speed technology of cloud computing. In short, if we try to summarize the situation, we would find that web mining concept has fuelled the entire process. This paper is an attempt to put light on the aspect of how web mining has penned the information age by co...

  11. Recent results from the Penning trap mass spectrometer ISOLTRAP

    CERN Document Server

    Blaum, Klaus; Beck, D; Bollen, Georg; Delahaye, P; Guenaut, C; Herfurth, F; Kellerbauer, Alban G; Kluge, H J; Lunney, M D; Rodríguez, D; Schwarz, S; Schweikhard, L; Weber, C; Yazidjian, C

    2004-01-01

    In the last few years a number of new scientific highlights have been obtained by ISOLTRAP, the tandem Penning trap mass spectrometer for on-line mass measurements of short-lived radionuclides. The precise determination of nuclear binding energies far from stability includes nuclei that are produced at rates of 100 ions/s and with half-lives below 100 ms. The mass resolving power reaches 10$^{7}$ and the uncertainty of the resulting mass values has been pushed down to $1 \\times 10^{-8}$. In this article recent ISOLTRAP mass measurements are summarized and the current status of ISOLTRAP is presented.

  12. Mechanism of force mode dip-pen nanolithography

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Haijun, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240 (China); Interfacial Water Division and Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, CAS, Shanghai 201800 (China); Xie, Hui; Rong, Weibin; Sun, Lining [State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, Harbin 150080 (China); Wu, Haixia; Guo, Shouwu, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240 (China); Wang, Huabin, E-mail: yanghaijun@sinap.ac.cn, E-mail: swguo@sjtu.edu.cn, E-mail: wanghuabin@cigit.ac.cn [Centre for Tetrahertz Research, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714 (China)

    2014-05-07

    In this work, the underlying mechanism of the force mode dip-pen nanolithography (FMDPN) is investigated in depth by analyzing force curves, tapping mode deflection signals, and “Z-scan” voltage variations during the FMDPN. The operation parameters including the relative “trigger threshold” and “surface delay” parameters are vital to control the loading force and dwell time for ink deposition during FMDPN. A model is also developed to simulate the interactions between the atomic force microscope tip and soft substrate during FMDPN, and verified by its good performance in fitting our experimental data.

  13. Prediction of suspended-sediment concentrations at selected sites in the Fountain Creek watershed, Colorado, 2008-09

    Science.gov (United States)

    Stogner, Robert W.; Nelson, Jonathan M.; McDonald, Richard R.; Kinzel, Paul J.; Mau, David P.

    2013-01-01

    In 2008, the U.S. Geological Survey (USGS), in cooperation with Pikes Peak Area Council of Governments, Colorado Water Conservation Board, Colorado Springs City Engineering, and the Lower Arkansas Valley Water Conservancy District, began a small-scale pilot study to evaluate the effectiveness of the use of a computational model of streamflow and suspended-sediment transport for predicting suspended-sediment concentrations and loads in the Fountain Creek watershed in Colorado. Increased erosion and sedimentation damage have been identified by the Fountain Creek Watershed Plan as key problems within the watershed. A recommendation in the Fountain Creek Watershed plan for management of the basin is to establish measurable criteria to determine if progress in reducing erosion and sedimentation damage is being made. The major objective of this study was to test a computational method to predict local suspended-sediment loads at two sites with different geomorphic characteristics in order to evaluate the feasibility of using such an approach to predict local suspended-sediment loads throughout the entire watershed. Detailed topographic surveys, particle-size data, and suspended-sediment samples were collected at two gaged sites: Monument Creek above Woodmen Road at Colorado Springs, Colorado (USGS gage 07103970), and Sand Creek above mouth at Colorado Springs, Colorado (USGS gage 07105600). These data were used to construct three-dimensional computational models of relatively short channel reaches at each site. The streamflow component of these models predicted a spatially distributed field of water-surface elevation, water velocity, and bed shear stress for a range of stream discharges. Using the model predictions, along with measured particle sizes, the sediment-transport component of the model predicted the suspended-sediment concentration throughout the reach of interest. These computed concentrations were used with predicted flow patterns and channel morphology to

  14. Products of Submarine Fountains and Bubble-burst Eruptive Activity at 1200 m on West Mata Volcano, Lau Basin

    Science.gov (United States)

    Clague, D. A.; Rubin, K. H.; Keller, N. S.

    2009-12-01

    An eruption was observed and sampled at West Mata Volcano using ROV JASON II for 5 days in May 2009 during the NSF-NOAA eruption response cruise to this region of suspected volcanic activity. Activity was focused near the summit at the Prometheus and Hades vents. Prometheus erupted almost exclusively as low-level fountains. Activity at Hades cycled between vigorous degassing, low fountains, and bubble-bursts, building up and partially collapsing a small spatter/scoria cone and feeding short sheet-like and pillow flows. Fire fountains at Prometheus produced mostly small primary pyroclasts that include Pele's hair and fluidal fragments of highly vesicular volcanic glass. These fragments have mostly shattered and broken surfaces, although smooth spatter-like surfaces also occur. As activity wanes, glow in the vent fades, and denser, sometimes altered volcanic clasts are incorporated into the eruption. The latter are likely from the conduit walls and/or vent-rim ejecta, drawn back into the vent by inrushing seawater that replaces water entrained in the rising volcanic plume. Repeated recycling of previously erupted materials eventually produces rounded clasts resembling beach cobbles and pitted surfaces on broken phenocrysts of pyroxene and olivine. We estimate that roughly 33% of near vent ejecta are recycled. Our best sample of this ejecta type was deposited in the drawer of the JASON II ROV during a particularly large explosion that occurred during plume sampling immediately above the vent. Elemental sulfur spherules up to 5 mm in diameter are common in ejecta from both vents and occur inside some of the lava fragments Hades activity included dramatic bubble-bursts unlike anything previously observed under water. The lava bubbles, sometimes occurring in rapid-fire sequence, collapsed in the water-column, producing fragments that are quenched in less than a second to form Pele's hair, limu o Pele, spatter-like lava blobs, and scoria. All are highly vesicular

  15. Upward Bound: An Untapped Fountain Of Youth Wanting To Learn About Math And Science

    Science.gov (United States)

    Gillis-Davis, J. J.; Sherman, S. B.; Gillis-Davis, L. C.; Svelling, K. L.

    2009-12-01

    , physics, math, and engineering. In addition, learning science through inquiry and experimentation lends tangible examples to abstract principles. Our curricula (available on-line for sharing) are comprised of (1) modular classroom lesson plans, (2) teacher tutorials, and (3) hands-on laboratory experiments. Each set of summer classes has a theme; the first set of summer classes centered on factors that affect climate on any planet. For example, students measured solar activity by counting sunspots and learned about the greenhouse effect by conducting experiments with colored bottles. The second summer focused on how the electromagnetic spectrum is fundamental to remote sensing. During our summer 2009 program the Lunar Reconnaissance Orbiter launched, and with its many instruments served as a shining example of how the electromagnetic spectrum is used to study planetary bodies. Thus, NASA archived and student-collected data sets used in a PBL setting provide the basic foundation for helping students learn science and math concepts, while the UB programs ensure sustainability by providing a fountain of youth who want to learn.

  16. Microfabricated modular scale-down device for regenerative medicine process development.

    Directory of Open Access Journals (Sweden)

    Marcel Reichen

    Full Text Available The capacity of milli and micro litre bioreactors to accelerate process development has been successfully demonstrated in traditional biotechnology. However, for regenerative medicine present smaller scale culture methods cannot cope with the wide range of processing variables that need to be evaluated. Existing microfabricated culture devices, which could test different culture variables with a minimum amount of resources (e.g. expensive culture medium, are typically not designed with process development in mind. We present a novel, autoclavable, and microfabricated scale-down device designed for regenerative medicine process development. The microfabricated device contains a re-sealable culture chamber that facilitates use of standard culture protocols, creating a link with traditional small-scale culture devices for validation and scale-up studies. Further, the modular design can easily accommodate investigation of different culture substrate/extra-cellular matrix combinations. Inactivated mouse embryonic fibroblasts (iMEF and human embryonic stem cell (hESC colonies were successfully seeded on gelatine-coated tissue culture polystyrene (TC-PS using standard static seeding protocols. The microfluidic chip included in the device offers precise and accurate control over the culture medium flow rate and resulting shear stresses in the device. Cells were cultured for two days with media perfused at 300 µl.h(-1 resulting in a modelled shear stress of 1.1×10(-4 Pa. Following perfusion, hESC colonies stained positively for different pluripotency markers and retained an undifferentiated morphology. An image processing algorithm was developed which permits quantification of co-cultured colony-forming cells from phase contrast microscope images. hESC colony sizes were quantified against the background of the feeder cells (iMEF in less than 45 seconds for high-resolution images, which will permit real-time monitoring of culture progress in future

  17. Vegetation survey of Pen Branch and Four Mile Creek wetlands

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    One hundred-fifty plots were recently sampled (vegetational sampling study) at the Savannah River Site (SRS). An extensive characterization of the vascular flora, in four predetermined strata (overstory, Understory, shrub layer, and ground cover), was undertaken to determine dominance, co-dominance, and the importance value (I.V.) of each species. These results will be used by the Savannah River Laboratory (SRL) to evaluate the environmental status of Four Mile Creek, Pen Branch, and two upland pine stands. Objectives of this study were to: Describe in detail the plant communities previously mapped with reference to the topography and drainage, including species of plants present: Examine the successional trends within each sampling area and describe the extent to which current vegetation communities have resulted from specific earlier vegetation disturbances (e.g., logging and grazing); describe in detail the botanical field techniques used to sample the flora; describe the habitat and location of protected and/or rare species of plants; and collect and prepare plant species as herbarium quality specimens. Sampling was conducted at Four Mile Creek and Pen Branch, and in two upland pine plantations of different age growth.

  18. Vegetation survey of Pen Branch and Four Mile Creek wetlands

    Energy Technology Data Exchange (ETDEWEB)

    1992-10-01

    One hundred-fifty plots were recently sampled (vegetational sampling study) at the Savannah River Site (SRS). An extensive characterization of the vascular flora, in four predetermined strata (overstory, Understory, shrub layer, and ground cover), was undertaken to determine dominance, co-dominance, and the importance value (I.V.) of each species. These results will be used by the Savannah River Laboratory (SRL) to evaluate the environmental status of Four Mile Creek, Pen Branch, and two upland pine stands. Objectives of this study were to: Describe in detail the plant communities previously mapped with reference to the topography and drainage, including species of plants present: Examine the successional trends within each sampling area and describe the extent to which current vegetation communities have resulted from specific earlier vegetation disturbances (e.g., logging and grazing); describe in detail the botanical field techniques used to sample the flora; describe the habitat and location of protected and/or rare species of plants; and collect and prepare plant species as herbarium quality specimens. Sampling was conducted at Four Mile Creek and Pen Branch, and in two upland pine plantations of different age growth.

  19. Infrared multiple photon dissociation spectroscopy of ions in Penning traps.

    Science.gov (United States)

    Eyler, John R

    2009-01-01

    The ability of Paul and Penning traps to contain ions for time periods ranging from milliseconds to minutes allows the trapped ions to be subjected to laser irradiation for extended lengths of time. In this way, relatively low-powered tunable infrared lasers can be used to induce ion fragmentation when a sufficient number of infrared photons are absorbed, a process known as infrared multiple photon dissociation (IRMPD). If ion fragmentation is monitored as a function of laser wavelength, a photodissociation action spectrum can be obtained. The development of widely tunable infrared laser sources, in particular free electron lasers (FELs) and optical parametric oscillators/amplifiers (OPO/As), now allows spectra of trapped ions to be obtained for the entire "chemically relevant" infrared spectral region. This review describes experiments in which tunable infrared lasers have been used to irradiate ions in Penning traps. Early studies which utilized tunable carbon dioxide lasers with a limited output range are first reviewed. More recent studies with either FEL or OPO/A irradiation sources are then covered. The ionic systems examined have ranged from small hydrocarbons to multiply charged proteins, and they are discussed in approximate order of increasing complexity.

  20. Spontaneous release of bacteriophage particles by Lactobacillus rhamnosus pen.

    Science.gov (United States)

    Jarocki, Piotr; Podleśny, Marcin; Pawelec, Jarosław; Malinowska, Agata; Kowalczyk, Sylwia; Targoński, Zdzisław

    2013-03-01

    The identification of bacteriophage proteins on the surface of Lactobacillus rhamnosus Pen was performed by LC-MS/MS analysis. Among the identified proteins, we found a phage-derived major tail protein, two major head proteins, a portal protein, and a host specificity protein. Electron microscopy of a cell surface extract revealed the presence of phage particles in the analyzed samples. The partial sequence of genes encoding the major tail protein for all tested L. rhamnosus strains was determined with specific primers designed in this study. Next, RT-PCR analysis allowed detection of the expression of the major tail protein gene in L. rhamnosus strain Pen at all stages of bacterial growth. The transcription of genes encoding the major tail protein was also proved for other L. rhamnosus strains used in this study. The present work demonstrates the spontanous release of prophage-encoded particles by a commercial probiotic L. rhamnosus strain, which did not significantly affect the bacterial growth of the analyzed strain.

  1. Development of hollow anode penning ion source for laboratory application

    Science.gov (United States)

    Das, B. K.; Shyam, A.; Das, R.; Rao, A. D. P.

    2012-03-01

    The research work presented here focuses for the development of miniature penning type ion source. One hollow anode penning type ion source was developed in our laboratory. The size of the ion source is 38 mm diameter and 55 mm length. The ion source consists of two cathodes, a hollow anode and one piece of rare earth permanent magnet. The plasma was created in the plasma region between cathodes and the hollow anode. The J × B force in the region helps for efficient ionization of the gas even in the high vacuum region˜1×10 -5 Torr. The ions were extracted in the axial direction with help of the potential difference between the electrodes and the geometry of the extraction angle. The effect of the extraction electrode geometry for efficient extraction of the ions from the plasma region was examined. This ion source is a self extracted ion source. The self extracted phenomena reduce the cost and the size of the ion source. The extracted ion current was measured by a graphite probe. An ion current of more than 200 μA was observed at the probe placed 70 mm apart from the extraction electrode. In this paper, the structure of the ion source, effect of operating pressure, potential difference and the magnetic field on the extracted ion current is reported.

  2. Defining the Pen Islands Caribou Herd of southern Hudson Bay

    Directory of Open Access Journals (Sweden)

    Kenneth F. Abraham

    1998-03-01

    Full Text Available In this paper, we describe the Pen Islands Herd of caribou, the largest aggregation of caribou in Ontario (it also occupies a portion of northeastern Manitoba. Photographic counts showed the herd had a minimum population of 2300 in 1979, 4660 in 1986, 7424 in 1987 and 10 798 in 1994. Throughout the 1980s, the Pen Islands caribou exhibited population behaviour similar to migratory barren-ground caribou herds, although morphology suggests they are woodland caribou or possibly a mixture of subspecies. The herd had well-defined traditional tundra calving grounds, formed nursery groups and large mobile post-calving aggregations, and migrated over 400 km between tundra summer habitats and boreal forest winter habitats. Its migration took it into three Canadian jurisdictions (Ontario, Manitoba, Northwest Territories and it was important to residents of both Manitoba and Ontario. It is clear that the herd should be managed as a migratory herd and the critical importance of both the coastal and variable large winter ranges should be noted in ensuring the herd's habitat needs are secure.

  3. Monte Carlo Simulations for Likelihood Analysis of the PEN experiment

    Science.gov (United States)

    Glaser, Charles; PEN Collaboration

    2017-01-01

    The PEN collaboration performed a precision measurement of the π+ ->e+νe(γ) branching ratio with the goal of obtaining a relative uncertainty of 5 ×10-4 or better at the Paul Scherrer Institute. A precision measurement of the branching ratio Γ(π -> e ν (γ)) / Γ(π -> μ ν (γ)) can be used to give mass bounds on ``new'', or non V -A, particles and interactions. This ratio also proves to be one of the most sensitive tests for lepton universality. The PEN detector consists of beam counters, an active target, a mini-time projection chamber, multi-wire proportional chamber, a plastic scintillating hodoscope, and a CsI electromagnetic calorimeter. The Geant4 Monte Carlo simulation is used to construct ultra-realistic events by digitizing energies and times, creating synthetic target waveforms, and fully accounting for photo-electron statistics. We focus on the detailed detector response to specific decay and background processes in order to sharpen the discrimination between them in the data analysis. Work supported by NSF grants PHY-0970013, 1307328, and others.

  4. Single-mask microfabrication of aspherical optics using KOH anisotropic etching of Si.

    Science.gov (United States)

    de Lima Monteiro, D W; Akhzar-Mehr, O; Sarro, P M; Vdovin, G

    2003-09-08

    We report on the microfabrication of continuous aspherical optical surfaces with a single-mask process, using anisotropic etching of silicon in a KOH water solution. Precise arbitrary aspherical surfaces with lateral scales on the order of several millimeters and a profile depth on the order of several micrometers were fabricated using this process. We discuss the factors defining the precision of the formed component and the resulting surface quality. We demonstrate 1 mm and 5 mm replicated aspherical phase plates, reproducing defocus, tilt, astigmatism and high-order aberrations. The technology has a potential for serial production of reflective and refractive arbitrary aspherical micro-optical components.

  5. Single-mask microfabrication of aspherical optics using KOH anisotropic etching of Si

    Science.gov (United States)

    de Lima Monteiro, D. W.; Akhzar-Mehr, O.; Sarro, P. M.; Vdovin, G.

    2003-09-01

    We report on the microfabrication of continuous aspherical optical surfaces with a single-mask process, using anisotropic etching of silicon in a KOH water solution. Precise arbitrary aspherical surfaces with lateral scales on the order of several millimeters and a profile depth on the order of several micrometers were fabricated using this process. We discuss the factors defining the precision of the formed component and the resulting surface quality. We demonstrate 1 mm and 5 mm replicated aspherical phase plates, reproducing defocus, tilt, astigmatism and high-order aberrations. The technology has a potential for serial production of reflective and refractive arbitrary aspherical micro-optical components.

  6. Microfabrication of an Implantable silicone Microelectrode array for an epiretinal prosthesis

    Energy Technology Data Exchange (ETDEWEB)

    Maghribi, M

    2003-06-10

    Millions of people suffering from diseases such as retinitis pigmentosa and macular degeneration are legally blind due to the loss of photoreceptor function. Fortunately a large percentage of the neural cells connected to the photoreceptors remain viable, and electrical stimulation of these cells has been shown to result in visual perception. These findings have generated worldwide efforts to develop a retinal prosthesis device, with the hope of restoring vision. Advances in microfabrication, integrated circuits, and wireless technologies provide the means to reach this challenging goal. This dissertation describes the development of innovative silicone-based microfabrication techniques for producing an implantable microelectrode array. The microelectrode array is a component of an epiretinal prosthesis being developed by a multi-laboratory consortium. This array will serve as the interface between an electronic imaging system and the human eye, directly stimulating retinal neurons via thin film conducting traces. Because the array is intended as a long-term implant, vital biological and physical design requirements must be met. A retinal implant poses difficult engineering challenges due to the size of the intraocular cavity and the delicate retina. Not only does it have to be biocompatible in terms of cytotoxicity and degradation, but it also has to be structurally biocompatible, with regard to smooth edges and high conformability; basically mimicking the biological tissue. This is vital to minimize stress and prevent physical damage to the retina. Also, the device must be robust to withstand the forces imposed on it during fabrication and implantation. In order to meet these biocompatibility needs, the use of non-conventional microfabrication materials such as silicone is required. This mandates the enhancement of currently available polymer-based fabrication techniques and the development of new microfabrication methods. Through an iterative process, devices

  7. Progressive evolution of microfabrics in high-temperature indentation creep experiments

    Science.gov (United States)

    Wassmann, S.; Dorner, D.; Stoeckhert, B.

    2014-12-01

    Microfabrics of natural rocks as well as of those deformed in laboratory experiments are studied post-mortem, the history of fabric evolution being inferred from a finite state. This is a major drawback when being interested in modification of fabrics related to progressive deformation. Here we present a novel approach to analyze and compare fabrics in different stages of evolution, taking spatial position to mimic a time series. Using this approach, evolution in time can be investigated on one sample deformed in a single indentation creep test. Such experiments at high temperatures and atmospheric pressure provide information on mechanical properties of rock-forming minerals as well as on microfabrics developed during inhomogeneous deformation underneath the indenter. Using a conventional creep apparatus, a cylindrical alumina indenter, 2 mm in diameter, is driven by a dead load into the flat surface of a specimen. A penetration depth of 1 mm is typically reached after hours to days, depending on material, applied temperature, and load. Previous experiments on natural, polycrystalline anhydrite carried out at temperatures between 700°C and 920 °C yield a stress exponent of 3.9 indicating deformation in the dislocation creep regime, consistent with microstructural observations (Dorner et al., 2014; Solid Earth). Within a cone-shaped region in front of the indenter, the original microfabric appears entirely unaffected. The neutral cone is mantled by highly deformed shear zones. During progressive indentation this structure of undeformed cone and shear zones propagates into the specimen. Thus, for a homogeneous starting material, serial sections of the deformed specimen normal to the indenter axis provide insight into fabrics in distinct stages of evolution. Microfabrics developed at different distance in front of the approaching indenter can be taken to represent a time series. A disadvantage of the technique is that the history of shear zone deformation is

  8. Current Developments in Electrophoretic and Chromatographic Separation Methods on Microfabricated Devices

    DEFF Research Database (Denmark)

    Kutter, Jörg Peter

    2000-01-01

    a brief overview of current developments in electrophoretic and chromatographic separation methods on microfabricated devices, and highlight some of the trends emerging from recent research results (published or pre-published before November 1999). (C)2000 Published by Elsevier Science B.V, All rights......Microchip-based separation techniques are essential elements in the development of fully integrated micro-total analysis systems, which are envisioned to become powerful instruments for obtaining and assessing analytical data in research, industry, and everyday life. This article's goal is to give...

  9. High-accuracy measurement of the {sup 87}Rb ground-state hyperfine splitting in an atomic fountain

    Energy Technology Data Exchange (ETDEWEB)

    Bize, S.; Sortais, Y.; Clairon, A. [Observatoire de Paris (France). BNM-LPTF; Santos, M.S. [Inst. de Fisica de Sao Carlos-USP, Dept. de Fisica e Ciencia dos Materiais, Sao Carlos (Brazil); Mandache, C. [Inst. National de Fizica Laserilor, Plasmei si Radiatiei, Bucuresti, Magurele (Romania); Salomon, C. [Lab. Kastler Brossel, Ecole Normale Superieure, Paris (France)

    1999-03-01

    We describe the operation of a laser-cooled rubidium {sup 87}Rb frequency standard. We present a new measurement of the {sup 87}Rb hyperfine frequency with a 1.3 x 10{sup -14} relative accuracy, by comparison with a Cs fountain primary standard. The measured {sup 87}Rb ground-state hyperfine splitting is {nu}{sup {sub 87}}{sub Rb} = 6 834 682 610.90429(9) Hz. This value differs from previously published values (see Essen L., Hope E. G. and Sutcliffe D. (1961); Penselin S., Moran T., Cohen W. and Winkler G. (1962); Arditi M. and Cerez P. (1972)) by about 2-3 Hz and is 10{sup 4} times more accurate. Because of the low collisional shift in {sup 87}Rb, future improvements may lead to a stability of 1 x 10{sup -14}{tau}{sup -1/2} and a relative accuracy in the 10{sup -17} range. (orig.) 23 refs.

  10. Isolation of Legionella pneumophila from cooling towers, public baths, hospitals, and fountains in Seoul, Korea, from 2010 to 2012.

    Science.gov (United States)

    Kim, Changkyu; Jeon, Sujin; Jung, Jihun; Oh, Younghee; Kim, Yeonsun; Lee, Jaein; Choi, Sungmin; Chae, Youngzoo; Lee, Young-Ki

    2015-01-01

    Legionnaire's disease is associated with a high mortality rate. The authors collected 3,495 water samples in Seoul, Korea, between 2010 and 2012 from public facilities (cooling towers, public baths, hospitals, and decorative fountains), which are considered the major habitats of Legionella pneumophila. In all, 527 (15.1%) isolates of L. pneumophila were obtained by microbial culture and polymerase chain reaction. Serological diagnosis and pulsed-field gel electrophoresis (PFGE) analysis were performed for the samples. The authors categorized the samples into four groups (A-D) on the basis of PFGE results. The analysis revealed that cooling towers containing the most samples with L. pneumophila serogroup 1 constituted the highest proportion of isolate. Samples from public facilities and serogroups could be distinctively classified by PFGE patterns. Thus, it is expected that source-specific features revealed through PFGE and serological analyses could serve as the basis for effectively coping with future outbreaks of L. pneumophila.

  11. Assessing usability, label comprehension, pen robustness and pharmacokinetics of a self-administered prefilled autoinjector pen of methotrexate in patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Jaime A Pachon

    2014-12-01

    Full Text Available Objective: To assess usability, bioavailability, and safety of subcutaneous self-administration of 0.3 mL of methotrexate 50 mg/mL solution via a prefilled autoinjector pen (methotrexate pen in patients with rheumatoid arthritis. Methods: The study enrolled methotrexate-naïve and methotrexate-experienced patients aged ≥16 years. Visit 1 (Day 1 included methotrexate pen usage training with documentation, patient self-injection, and a patient-training questionnaire completed by the healthcare professional. Visit 2 (Days 8–10 included evaluation of patient self-injection through four scenarios: holding needle in place for 5 s, confirming methotrexate delivery, skin pinch, and pen disposal. At Visit 2, patient opinion and training retention (since Visit 1 were also assessed. Pharmacokinetic parameters were assessed in 25 patients, who were stratified by body weight and randomized to receive injections in the abdomen or the upper thigh. Results: At Visit 1, 12 of 106 patients had questions about the pen, and 4 required self-injection assistance. At Visit 2, the mean performance rating for all scenarios was ≥9.8 (scale: 1 (very difficult−10 (very easy. Successful completion rates were 96.2%–100%; 91.3%–100% of patients required no assistance. Impressions of the pen were favorable; 98.1% of patients passed the written examination. All methotrexate pens effectively delivered 0.3 mL methotrexate and were intact after use. Body weight >100 kg significantly decreased total and peak methotrexate exposure when administered abdominally. No adverse effects resulted in drug discontinuation. Conclusion: The methotrexate pen was used with a high degree of effectiveness, satisfaction, and safety, indicating that this delivery system may be a viable option for patients requiring subcutaneous methotrexate.

  12. Microfabrication and Performance of Annealed NiTi Shape Memory Thin Films by Sputtering for Microdevice Applications

    Institute of Scientific and Technical Information of China (English)

    GONG Feng-fei.

    2004-01-01

    The microfabrication and performance NiTi shape memory thin films for microdevice applications were studied by microfabrication processes, which were compatible with those of microelectronics fabrication processes. The sputter-deposition conditions, patterning process, and annealing conditions were investigated. The B2 crystal structures of the thin films can be obtained by annealing at 525℃ for 30min. The results from x-ray photoemission spectroscopy indicated that the atomic concentration in the surface of the annealed thin films with preferred structures is comparable with those of the as-deposited films.

  13. Micro-beam and pulsed laser beam techniques for the micro-fabrication of diamond surface and bulk structures

    Energy Technology Data Exchange (ETDEWEB)

    Sciortino, S. [Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Bellini, M. [European Laboratory for Non-Linear Spectroscopy, Via Nello Carrara 1, 50019 Sesto Fiorentino (Italy); Istituto Nazionale di Ottica (INO-CNR), Largo Enrico Fermi 6, 50125 Firenze (Italy); Bosia, F. [Physics Department and “Nanostructured Interfaces and Surfaces” Inter-departmental Centre, University of Torino, via P. Giuria 1, 10125 Torino (Italy); INFN Sezione di Torino, via P. Giuria 1, 10125 Torino (Italy); Calusi, S. [Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Corsi, C. [Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); European Laboratory for Non-Linear Spectroscopy, Via Nello Carrara 1, 50019 Sesto Fiorentino (Italy); Czelusniak, C. [Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Gelli, N. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); and others

    2015-04-01

    Micro-fabrication in diamond is applicable in a wide set of emerging technologies, exploiting the exceptional characteristics of diamond for application in bio-physics, photonics and radiation detection. Micro ion-beam irradiation and pulsed laser irradiation are complementary techniques, which permit the implementation of complex geometries, by modification and functionalization of surface and/or bulk material, modifying the optical, electrical and mechanical characteristics of the material. In this article we summarize the work done in Florence (Italy), concerning ion beam and pulsed laser beam micro-fabrication in diamond.

  14. A Context-Aware Infrastructure for Supporting Applications with Pen-Based Interaction

    Institute of Scientific and Technical Information of China (English)

    LI Yang(栗阳); GUAN ZhiWei(关志伟); DAI GuoZhong(戴国忠); REN XiangShi(任向实); HAN Yong(韩勇)

    2003-01-01

    Pen-based user interfaces which leverage the affordances of the pen provide userswith more flexibility and natural interaction. However, it is difficult to construct usable pen-baseduser interfaces because of the lack of support for their development. Toolkit-level support has beenexploited to solve this problem, but this approach makes it hard to gain platform independence,easy maintenance and easy extension. In this paper a context-aware infrastructure is created,called WEAVER, to provide pen interaction services for both novel pen-based applications andlegacy GUI-based applications. WEAVER aims to support the pen as another standard interactivedevice along with the keyboard and mouse and present a high-level access interface to pen input.It employs application context to tailor its service to different applications. By modeling theapplication context and registering the relevant action adapters, WEAVER can offer services,such as gesture recognition, continuous handwriting and other fundamental ink manipulations, toappropriate applications. One of the distinct features of WEAVER is that off-the-shelf GUI-basedsoftware packages can be easily enhanced with pen interaction without modifying the existing code.In this paper, the architecture and components of WEAVER are described. In addition, examplesand feedbacks of its use are presented.

  15. Submovement organization, pen pressure, and muscle activity are modulated to precision demands in 2D tracking

    NARCIS (Netherlands)

    Huysmans, M.A.; Hoozemans, M.J.M.; Beek, A.J. van der; Looze, M.P. de; Dien, J.H. van

    2012-01-01

    The authors investigated how tracking performance, submovement organization, pen pressure and muscle activity in forearm and shoulder muscles were affected by target size in a 2D tracking task performed with a pen on a digitizer tablet. Twenty-six subjects took part in an experiment, in which either

  16. Lessons from the operation of the `Penning-Fluorescent' TPC and prospects

    CERN Document Server

    Gonzalez-Diaz, Diego; Castel, J; Cebrian, S; Dafni, T; Garcia, J A; Gomez, H; Herrera, D C; Iguaz, F J; Irastorza, I G; Lagraba, A; Luzon, G; Rodriguez, A; Ruiz-Choliz, E; Ferrer-Ribas, A Tomas E; Giomataris, I

    2015-01-01

    We have recently reported the development of a new type of high-pressure Xenon time projection chamber operated with an ultra-low diffusion mixture and that simultaneously displays Penning effect and fluorescence in the near-visible region (300 nm). The concept, dubbed `Penning-Fluorescent' TPC, allows the simultaneous reconstruction of primary charge and scintillation with high topological and calorimetric fidelity.

  17. Rap van tong, scherp van pen. Literaire discussiecultuur in Nederlandse praatjespamfletten (circa 1600-1750)

    NARCIS (Netherlands)

    Dingemanse, C.W.

    2008-01-01

    In the early modern period pamphlets constituted the most important medium to influence public opinion in the Netherlands. The thesis Rap van tong, scherp van pen (Glib tongues, sharp pens) focuses on the literary and rhetorical aspects of a remarkable type of pamphlet called praatje (small-talk), w

  18. Rap van tong, scherp van pen. Literaire discussiecultuur in Nederlandse praatjespamfletten (circa 1600-1750)

    NARCIS (Netherlands)

    Dingemanse, C.W.

    2008-01-01

    In the early modern period pamphlets constituted the most important medium to influence public opinion in the Netherlands. The thesis Rap van tong, scherp van pen (Glib tongues, sharp pens) focuses on the literary and rhetorical aspects of a remarkable type of pamphlet called praatje (small-talk),

  19. Rap van tong, scherp van pen. Literaire discussiecultuur in Nederlandse praatjespamfletten (circa 1600-1750)

    NARCIS (Netherlands)

    Dingemanse, C.W.

    2008-01-01

    In the early modern period pamphlets constituted the most important medium to influence public opinion in the Netherlands. The thesis Rap van tong, scherp van pen (Glib tongues, sharp pens) focuses on the literary and rhetorical aspects of a remarkable type of pamphlet called praatje (small-talk), w

  20. Use of Reading Pen Assistive Technology to Accommodate Post-Secondary Students with Reading Disabilities

    Science.gov (United States)

    Schmitt, Ara J.; McCallum, Elizabeth; Hennessey, Jenna; Lovelace, Temple; Hawkins, Renee O.

    2012-01-01

    Reading pens are a form of assistive technology that may be used to bypass weak word decoding and vocabulary skills of students with reading disabilities. Only two known studies have examined the effects of reading pens on the comprehension of school-aged students, and no known studies have been published regarding post-secondary students. The…

  1. Performance study on touch-pens size in three screen tasks.

    Science.gov (United States)

    Wu, Fong-Gong; Luo, Shuyi

    2006-03-01

    Experiments were aimed at investigating the performance of various sizes of touch-pens. The touch-pens were of three different lengths (80, 110 and 140 mm) and four different diameters (5.5, 8, 11 and 15 mm). Three screen tasks were used for determining a reference of ideal dimensions of a pen-based product. Sixteen subjects used 12 touch-pens to perform pointing-and-clicking, writing and drawing tasks. The subjects were asked to rank their preference after each task in the test. The results showed that the length of touch-pens should be designed to extend beyond the handbreadth when gripped. A touch-pen that facilitates natural pointing-and-clicking, writing and drawing tasks each requires a suitable diameter size. However, these tasks are typically performed together, in particular, the pointing-and-clicking and writing tasks. The recommended diameter for all three combined tasks is 8 mm. This finding indicates that selecting a touch-pen with a diameter of 8 mm and a length of 100 mm or longer is suitable for all pen-based devices.

  2. 9 CFR 309.1 - Ante-mortem inspection in pens of official establishments.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Ante-mortem inspection in pens of... AND VOLUNTARY INSPECTION AND CERTIFICATION ANTE-MORTEM INSPECTION § 309.1 Ante-mortem inspection in...) Such ante-mortem inspection shall be made in pens on the premises of the establishment at which...

  3. Gender Representation in an Electronic City Hall: Female Adoption of Santa Monica's PEN System.

    Science.gov (United States)

    Collins-Jarvis, Lori A.

    1993-01-01

    Discussion of the use of electronic networking systems by women focuses on a study of their use of the Public Electronic Network (PEN) in Santa Monica (California). Characteristics of PEN that contributed to female adoption are described; gender, political participation, and motivation are examined; and future research is suggested. (46…

  4. Reusable and disposable insulin pens for the treatment of diabetes: understanding the global differences in user preference and an evaluation of inpatient insulin pen use.

    Science.gov (United States)

    Perfetti, Riccardo

    2010-06-01

    Insulin is essential for the management of type 1 diabetes and is more commonly being used for the treatment of type 2 diabetes. Insulin pen devices were first introduced over 20 years ago and have evolved to provide significant practical advantages compared with the vial and syringe. Pen devices are now used by patients with diabetes worldwide, but there are marked geographical variations in the use of reusable and disposable pens. In some countries the vial and syringe is still the most popular method of administering insulin, whereas in other countries the use of reusable or disposable pens is more prevalent. Therefore, the aim of this review is to discuss the factors that seem to be involved in these differences, which include patient access to insulin, cost, and physician/patient awareness and preference. Inpatient use of insulin is also common, and the use of insulin pens could offer substantial benefits in this patient population, not only during the admission period but also after discharge from the hospital. However, the evidence base for inpatient use is still weak, and more studies are needed to investigate the use of insulin pens in this patient population.

  5. Dynamic monitoring of weight data at the pen vs at the individual level

    DEFF Research Database (Denmark)

    Jensen, Dan Børge; Toft, Nils; Kristensen, Anders Ringgaard

    recorded weight data from finisher pigs. Data are collected at insertion and at the exit of the first pigs in the pen, and in few pens, the weight is recorded weekly. Dynamic linear models are fitted on the weight data, at the pig level (univariate), at the double pen level using averaged weight...... (univariate) and using individual pig values as parameters in a hierarchical (multivariate) model including section, double pen, and individual level. Variance components of the different models are estimated using the Expectation Maximization algorithm. The difference of information obtained...... at the individual vs. pen level is thereafter assessed. Whereas weight data is usually monitored after a batch is being sent to the slaughter house, this method provides with weekly updating of the data. Perspectives of application include dynamic monitoring of weight data in relation to events such as diarrhoea...

  6. Dynamic monitoring of weight data at the pen vs at the individual level

    DEFF Research Database (Denmark)

    Jensen, Dan; Toft, Nils; Kristensen, A. R. K.

    recorded weight data from finisher pigs. Data are collected at insertion and at the exit of the first pigs in the pen, and in few pens, the weight is recorded weekly. Dynamic linear models are fitted on the weight data, at the pig level (univariate), at the double pen level using averaged weight...... (univariate) and using individual pig values as parameters in a hierarchical (multivariate) model including section, double pen, and individual level. Variance components of the different models are estimated using the Expectation Maximization algorithm. The difference of information obtained...... at the individual vs pen level is thereafter assessed. Whereas weight data is usually monitored after a batch is being sent to the slaughter house, this method provides weekly updating of the data. Perspectives of application include dynamic monitoring of weight data in relation to events such as diarrhoea, tail...

  7. Development of Microfabricated Chemical Gas Sensors and Sensor Arrays for Aerospace Applications

    Science.gov (United States)

    Hunter, G. W.; Neudeck, P. G.; Fralick, G.; Thomas, V.; Liu, C. C.; Wu, W. H.; Ward, B.; Makel, D.

    2002-01-01

    Aerospace applications require the development of chemical sensors with capabilities beyond those of commercially available sensors. In particular, factors such as minimal sensor size, weight, and power consumption are particularly important. Development areas which have potential aerospace applications include launch vehicle leak detection, engine health monitoring, fire detection, and environmental monitoring. Sensor development for these applications is based on progress in three types of technology: 1) Micromachining and microfabrication (Microsystem) technology to fabricate miniaturized sensors. 2) The use of nanocrystalline materials to develop sensors with improved stability combined with higher sensitivity. 3) The development of high temperature semiconductors, especially silicon carbide. However, due to issues of selectivity and cross-sensitivity, individual sensors are limited in the amount of information that they can provide in environments that contain multiple chemical species. Thus, sensor arrays are being developed to address detection needs in such multi-species environments. This paper discusses the needs of space applications as well as the point-contact sensor technology and sensor arrays being developed to address these needs. Sensors to measure hydrogen, hydrocarbons, hydrazine, nitrogen oxides (NO,), carbon monoxide, oxygen, and carbon dioxide are being developed as well as arrays for leak, fire, and emissions detection. Demonstrations of the technology will also be discussed. It is concluded that microfabricated sensor technology has significant potential for use in a range of aerospace applications.

  8. Development and Application of Microfabricated Chemical Gas Sensors For Aerospace Applications

    Science.gov (United States)

    Hunter, G. W.; Neudeck, P. G.; Fralick, G.; Thomas, V.; Liu, C. C.; Wu, Q. H.; Sawayda, M. S.; Jin, A.; Hammond, J.; Makel, D.; Hall, G.

    1990-01-01

    Aerospace applications require the development of chemical sensors with capabilities beyond those of commercially available sensors. In particular, factors such as minimal sensor size, weight, and power consumption are particularly important. Development areas which have potential aerospace applications include launch vehicle leak detection, engine health monitoring and control, and fire detection. Sensor development for these applications is based on progress in three types of technology: 1) Micromachining and microfabrication (Microsystem) technology to fabricate miniaturized sensors. 2) The use of nanocrystalline materials to develop sensors with improved stability combined with higher sensitivity. 3) The development of high temperature semiconductors, especially silicon carbide. Sensor development for each application involves its own challenges in the fields of materials science and fabrication technology. This paper discusses the needs of space applications and the point-contact sensor technology being developed to address these needs. Sensors to measure hydrogen, hydrocarbons, nitrogen oxides (Nox, carbon monoxide, oxygen, and carbon dioxide are being developed. A description is given of each sensor type and its present stage of development. Demonstration and application these sensor technologies will be described. The demonstrations range from use of a microsystem based hydrogen sensor on the Shuttle to engine demonstration of a nanocrystalline based sensor for NO, detection. It is concluded that microfabricated sensor technology has significant potential for use in a range of aerospace applications.

  9. Microfabricated Electrochemical Cell-Based Biosensors for Analysis of Living Cells In Vitro

    Directory of Open Access Journals (Sweden)

    Jun Wang

    2012-04-01

    Full Text Available Cellular biochemical parameters can be used to reveal the physiological and functional information of various cells. Due to demonstrated high accuracy and non-invasiveness, electrochemical detection methods have been used for cell-based investigation. When combined with improved biosensor design and advanced measurement systems, the on-line biochemical analysis of living cells in vitro has been applied for biological mechanism study, drug screening and even environmental monitoring. In recent decades, new types of miniaturized electrochemical biosensor are emerging with the development of microfabrication technology. This review aims to give an overview of the microfabricated electrochemical cell-based biosensors, such as microelectrode arrays (MEA, the electric cell-substrate impedance sensing (ECIS technique, and the light addressable potentiometric sensor (LAPS. The details in their working principles, measurement systems, and applications in cell monitoring are covered. Driven by the need for high throughput and multi-parameter detection proposed by biomedicine, the development trends of electrochemical cell-based biosensors are also introduced, including newly developed integrated biosensors, and the application of nanotechnology and microfluidic technology.

  10. Microfabrication of a High-Throughput Nanochannel Delivery/Filtration System

    Science.gov (United States)

    Ferrari, Mauro; Liu, Xuewu; Grattoni, Alessandro; Fine, Daniel; Hosali, Sharath; Goodall, Randi; Medema, Ryan; Hudson, Lee

    2011-01-01

    A microfabrication process is proposed to produce a nanopore membrane for continuous passive drug release to maintain constant drug concentrations in the patient s blood throughout the delivery period. Based on silicon microfabrication technology, the dimensions of the nanochannel area, as well as microchannel area, can be precisely controlled, thus providing a steady, constant drug release rate within an extended time period. The multilayered nanochannel structures extend the limit of release rate range of a single-layer nanochannel system, and allow a wide range of pre-defined porosity to achieve any arbitrary drug release rate using any preferred nanochannel size. This membrane system could also be applied to molecular filtration or isolation. In this case, the nanochannel length can be reduced to the nanofabrication limit, i.e., 10s of nm. The nanochannel delivery system membrane is composed of a sandwich of a thin top layer, the horizontal nanochannels, and a thicker bottom wafer. The thin top layer houses an array of microchannels that offers the inlet port for diffusing molecules. It also works as a lid for the nanochannels by providing the channels a top surface. The nanochannels are fabricated by a sacrificial layer technique that obtains smooth surfaces and precisely controlled dimensions. The structure of this nanopore membrane is optimized to yield high mechanical strength and high throughput.

  11. Microfabrication, characterization and in vivo MRI compatibility of diamond microelectrodes array for neural interfacing

    Energy Technology Data Exchange (ETDEWEB)

    Hébert, Clément, E-mail: clement.hebert@cea.fr [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble Cedex 9 (France); Warnking, Jan; Depaulis, Antoine [INSERM, U836, Grenoble Institut des Neurosciences, Grenoble (France); Garçon, Laurie Amandine [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble Cedex 9 (France); CEA/INAC/SPrAM/CREAB, 17 rue des Martyrs, 38054 Grenoble Cedex 9 (France); Mermoux, Michel [Université Grenoble Alpes, LEPMI, F-38000 Grenoble (France); CNRS, LEPMI, F-38000 Grenoble (France); Eon, David [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble Cedex 9 (France); Mailley, Pascal [CEA-LETI-DTBS Minatec, 17 rue des Martyres, 38054 Grenoble (France); Omnès, Franck [Institut Néel, CNRS et Université Joseph Fourier, BP 166, F-38042 Grenoble Cedex 9 (France)

    2015-01-01

    Neural interfacing still requires highly stable and biocompatible materials, in particular for in vivo applications. Indeed, most of the currently used materials are degraded and/or encapsulated by the proximal tissue leading to a loss of efficiency. Here, we considered boron doped diamond microelectrodes to address this issue and we evaluated the performances of a diamond microelectrode array. We described the microfabrication process of the device and discuss its functionalities. We characterized its electrochemical performances by cyclic voltammetry and impedance spectroscopy in saline buffer and observed the typical diamond electrode electrochemical properties, wide potential window and low background current, allowing efficient electrochemical detection. The charge storage capacitance and the modulus of the electrochemical impedance were found to remain in the same range as platinum electrodes used for standard commercial devices. Finally we observed a reduced Magnetic Resonance Imaging artifact when the device was implanted on a rat cortex, suggesting that boron doped-diamond is a very promising electrode material allowing functional imaging. - Highlights: • Microfabrication of all-diamond microelectrode array • Evaluation of as-grown nanocrystalline boron-doped diamond for electrical neural interfacing • MRI compatibility of nanocrystalline boron-doped diamond.

  12. Micro-fabricated shunt to mimic arachnoid granulations for the treatment of communicating hydrocephalus.

    Science.gov (United States)

    Kralick, Francis; Oh, Jonghyun; Medina, Tim; Noh, Hongseok Moses

    2012-01-01

    Hydrocephalus is the abnormal accumulation of cerebrospinal fluid (CSF) within the confines of the skull that if left untreated results in significant morbidity and mortality. The treatment for hydrocephalus has remained essentially unchanged for over 50 years. It was a technological advance in materials that allowed John Holter, in conjunction with neurosurgeons Spitzer and Nulsen, to devise a valve and shunt system that diverted excess CSF from the ventricular space to the peritoneum. This ventriculo-peritoneal (VP) shunt is far from ideal, with problems associated with under/over shunting, mechanical mismatch, infection, high failure rates, disconnection and erosion. With the advances in the field of micro-fabrication and micro-machines we propose an innovative shunt system that would mimic the function of arachnoid granulations. This micro-fabricated shunting device, or micro-mechanical arachnoid granulation (MAG), consists of a multiplicity of micro-valves each 210 μm in diameter that each adhere to individual micro-needles. This work demonstrates the design and initial test results of the micro-valve with parameters for low cracking pressure, optimal flow rate, and reflux that would mimic the function of the native arachnoid granulations.

  13. Glass Imprint Templates by Spark Assisted Chemical Engraving for Microfabrication by Hot Embossing

    Directory of Open Access Journals (Sweden)

    Lucas Abia Hof

    2017-01-01

    Full Text Available As the field of microelectromechanical systems (MEMS matures, new demands are being placed on the microfabrication of complex architectures in robust materials, such as hard plastics. Iterative design optimization in a timely manner—rapid prototyping—places challenges on template fabrication, for methods such as injection moulding and hot embossing. In this paper, we demonstrate the possibility of using spark assisted chemical engraving (SACE to produce micro patterned glass templates. The direct, write-based approach enabled the facile fabrication of smooth microfeatures with variations in all three-dimensions, which could be replicated by hot embossing different thermoplastics. As a proof of principle, we demonstrated the technique for a high glass transition temperature polycarbonate. Good fidelity over more than 10 cycles provides evidence that the approach is viable for rapid prototyping and has the potential to satisfy commercial-grade production at medium-level output volumes. Glass imprint templates showed no degradation after use, but care must be taken due to brittleness. The technique has the potential to advance microfabrication needs in academia and could be used by MEMS product developers.

  14. The Penning trap system used by the BASE experiment

    CERN Multimedia

    Marcastel, Fabienne

    2015-01-01

    A cut-away schematic of the Penning trap system used by BASE. The experiment receives antiprotons from CERN's AD; negative hydrogen ions are formed during injection into the apparatus. The set-up works with only a pair of particles at a time, while a cloud of a few hundred others are held in the reservoir trap, for future use. Here, an antiproton is in the measurement trap, while the negative hydyrogen ion is in held by the downstream park electrode. When the antiproton has been measured, it is moved to the upstream park electrode and the hydrogen ion is brought in to the measurement trap. This is repeated thousands of times, enabling a high-precision comparison of the charge-to-mass ratios of the two particles.

  15. Dip-pen nanolithography-assisted protein crystallization.

    Science.gov (United States)

    Ielasi, Francesco S; Hirtz, Michael; Sekula-Neuner, Sylwia; Laue, Thomas; Fuchs, Harald; Willaert, Ronnie G

    2015-01-14

    We demonstrate the use of dip-pen nanolithography (DPN) to crystallize proteins on surface-localized functionalized lipid layer arrays. DOPC lipid layers, containing small amounts of biotin-DOPE lipid molecules, were printed on glass substrates and evaluated in vapor diffusion and batch crystallization screening setups, where streptavidin was used as a model protein for crystallization. Independently of the crystallization system used and the geometry of the lipid layers, nucleation of streptavidin crystals occurred specifically on the DPN-printed biotinylated structures. Protein crystallization on lipid array patches is also demonstrated in a microfluidic chip, which opens the way toward high-throughput screening to find suitable nucleation and crystal growth conditions. The results demonstrate the use of DPN in directing and inducing protein crystallization on specific surface locations.

  16. Mass Measurements with the Canadian Penning Trap at CARIBU

    Science.gov (United States)

    Orford, Rodney

    2017-01-01

    Roughly half of the elements heavier than iron are thought to be produced through the astrophysical r process of nucleosynthesis. Despite its large influence in explaining the observed abundance of heavy elements, much of the r process is still poorly understood. A more thorough library of nuclear data of neutron-rich nuclei is needed to improve the accuracy and progression of r-process calculations. In particular, accurate mass measurements are in demand due to the strong coupling between mass and other nuclear properties such as β-decay and neutron-capture rates. For nearly three decades, direct mass measurements conducted by Penning trap mass spectrometers have proven to be an accurate method of determining masses to a precision suitable for r-process calculations (Δm / m Science User Facility.

  17. Operation of the CSNS Penning surface H~- ion source

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The accelerator complex of the China Spallation Neutron Source (CSNS) consists of a H- linear accelerator (linac) and a rapid cycling synchrotron (RCS). The linac contains a Penning surface H- ion source. The designed energy and the beam current of the source are 50 keV and 20 mA respectively, with a normalized root mean square (norm. rms.) emittance of 0.2π mm mrad. The manufactures and tests of the discharge chamber are in great progress. The construction of H- ion source test stand has been completed, and the operation of the source is also in progress. Stable H- ion beams with energy of 50 keV and current up to 50 mA are attained. Emittance measurement for the H- beam is being prepared.

  18. Fabrication of anode supported PEN for solid oxide fuel cell

    Institute of Scientific and Technical Information of China (English)

    谢淑红; 崔崑; 夏风; 肖建中

    2004-01-01

    Fabrication process for anode supported planar PEN of intermediate temperature solid oxide fuel cell (SOFC) was introduced, in which tape casting and screen printing methods were used. Gd2O3 doped CeO2(GDC) powders were prepared by solid reaction method. Anode tape was produced by tape casting. Electrolyte and cathode were produced by screen printing. The GDC powder's component, thermal expand coefficient, the porosity, density and microstructure of anode and electrolyte were investigated . It was shown that an bi-layer with dense thin electrolyte film and porous anode support and with good coherency of the electrolyte film to the anode could be realized after co-sintering the green tape at 1 350℃ by optimizing the power characteristics of the starting materials in the slurry.

  19. Rapid crystallization of externally produced ions in a Penning trap

    CERN Document Server

    Murboeck, T; Birkl, G; Noertershaeuser, W; Thompson, R C; Vogel, M

    2016-01-01

    We have studied the cooling dynamics, formation process and geometric structure of mesoscopic crystals of externally produced magnesium ions in a Penning trap. We present a cooling model and measurements for a combination of buffer gas cooling and laser cooling which has been found to reduce the ion kinetic energy by eight orders of magnitude from several hundreds of eV to micro-eV and below within seconds. With ion numbers of the order of 1000 to 100000, such cooling leads to the formation of ion Coulomb crystals which display a characteristic shell structure in agreement with theory of non-neutral plasmas. We show the production and characterization of two-species ion crystals as a means of sympathetic cooling of ions lacking a suitable laser-cooling transition.

  20. Resolved-Sideband Laser Cooling in a Penning Trap.

    Science.gov (United States)

    Goodwin, J F; Stutter, G; Thompson, R C; Segal, D M

    2016-04-08

    We report the laser cooling of a single ^{40}Ca^{+} ion in a Penning trap to the motional ground state in one dimension. Cooling is performed in the strong binding limit on the 729-nm electric quadrupole S_{1/2}↔D_{5/2} transition, broadened by a quench laser coupling the D_{5/2} and P_{3/2} levels. We find the final ground-state occupation to be 98(1)%. We measure the heating rate of the trap to be very low with n[over ¯][over ˙]≈0.3(2)  s^{-1} for trap frequencies from 150-400 kHz, consistent with the large ion-electrode distance.

  1. Clickable Antifouling Polymer Brushes for Polymer Pen Lithography.

    Science.gov (United States)

    Bog, Uwe; de Los Santos Pereira, Andres; Mueller, Summer L; Havenridge, Shana; Parrillo, Viviana; Bruns, Michael; Holmes, Andrea E; Rodriguez-Emmenegger, Cesar; Fuchs, Harald; Hirtz, Michael

    2017-04-05

    Protein-repellent reactive surfaces that promote localized specific binding are highly desirable for applications in the biomedical field. Nonspecific adhesion will compromise the function of bioactive surfaces, leading to ambiguous results of binding assays and negating the binding specificity of patterned cell-adhesive motives. Localized specific binding is often achieved by attaching a linker to the surface, and the other side of the linker is used to bind specifically to a desired functional agent, as e.g. proteins, antibodies, and fluorophores, depending on the function required by the application. We present a protein-repellent polymer brush enabling highly specific covalent surface immobilization of biorecognition elements by strain-promoted alkyne-azide cycloaddition click chemistry for selective protein adhesion. The protein-repellent polymer brush is functionalized by highly localized molecular binding sites in the low micrometer range using polymer pen lithography (PPL). Because of the massive parallelization of writing pens, the tunable PPL printed patterns can span over square centimeter areas. The selective binding of the protein streptavidin to these surface sites is demonstrated while the remaining polymer brush surface is resisting nonspecific adsorption without any prior blocking by bovine serum albumin (BSA). In contrast to the widely used BSA blocking, the reactive polymer brushes are able to significantly reduce nonspecific protein adsorption, which is the cause of biofouling. This was achieved for solutions of single proteins as well as complex biological fluids. The remarkable fouling resistance of the polymer brushes has the potential to improve the multiplexing capabilities of protein probes and therefore impact biomedical research and applications.

  2. Two-photon polymerization microfabrication of hydrogels: an advanced 3D printing technology for tissue engineering and drug delivery.

    Science.gov (United States)

    Xing, Jin-Feng; Zheng, Mei-Ling; Duan, Xuan-Ming

    2015-08-07

    3D printing technology has attracted much attention due to its high potential in scientific and industrial applications. As an outstanding 3D printing technology, two-photon polymerization (TPP) microfabrication has been applied in the fields of micro/nanophotonics, micro-electromechanical systems, microfluidics, biomedical implants and microdevices. In particular, TPP microfabrication is very useful in tissue engineering and drug delivery due to its powerful fabrication capability for precise microstructures with high spatial resolution on both the microscopic and the nanometric scale. The design and fabrication of 3D hydrogels widely used in tissue engineering and drug delivery has been an important research area of TPP microfabrication. The resolution is a key parameter for 3D hydrogels to simulate the native 3D environment in which the cells reside and the drug is controlled to release with optimal temporal and spatial distribution in vitro and in vivo. The resolution of 3D hydrogels largely depends on the efficiency of TPP initiators. In this paper, we will review the widely used photoresists, the development of TPP photoinitiators, the strategies for improving the resolution and the microfabrication of 3D hydrogels.

  3. Extremely Strong ^{13}CO J=3-2 Line in the "Water Fountain" IRAS 16342-3814: Evidence for the Hot-Bottom Burning

    CERN Document Server

    Imai, Hiroshi; He, Jin-Hua; Nakashima, Jun-ichi; Hsia, Chih-Hao; Sakai, Takeshi; Deguchi, Shuji; Koning, Nico

    2012-01-01

    We observed four "water fountain" sources in the CO J=3-2 line emission with the Atacama Submillimeter Telescope Experiment (ASTE) 10 m telescope in 2010-2011. The water fountain sources are evolved stars that form high-velocity collimated jets traced by water maser emission. The CO line was detected only from IRAS 16342-3814. The present work confirmed that the ^{12}CO to ^{13}CO line intensity ratio is ~1.5 at the systemic velocity. We discuss the origins of the very low ^{12}CO to ^{13}CO intensity ratio, as possible evidence for the "hot-bottom burning" in an oxygen-rich star, and the CO intensity variation in IRAS 16342-3814.

  4. Identification of colorants in pigmented pen inks by laser desorption mass spectrometry.

    Science.gov (United States)

    Papson, Kaitlin; Stachura, Sylwia; Boralsky, Luke; Allison, John

    2008-01-01

    Pigments are rapidly replacing dyes as colorants in pen and printer inks, due to their superior colors and stability. Unfortunately, tools commonly used in questioned document examination for analyzing pen inks, such as TLC, cannot be used for the analysis of insoluble pigments on paper. Laser desorption mass spectrometry is demonstrated here as a tool for analyzing pigment-based pen inks. A pulsed nitrogen laser can be focused onto a pen stroke from a pigmented ink pen on paper, and positive and negative ions representative of the pigment can be generated for subsequent mass spectrometric analysis. Targeted pens for this work were a set of Uni-ball 207 pigmented ink pens containing blue, light blue, orange, green, violet, red, pink, and black inks. Copper phthalocyanine was identified as the pigment used to make both blue inks. A mixture of halogenated copper phthalocyanines were identified in the green ink. Unexpectedly, the pink ink was found to contain a red pigment, Pigment Red 12, treated with a mixture of water-soluble dyes. Each sample yielded ions representative of the pigments present.

  5. RESEARCHES REGARDING THE MAIN REPRODUCTION INDICATORS DETERMINATED IN SOWS, STAND GESTATION PEN TIPE

    Directory of Open Access Journals (Sweden)

    RAMONA UNTARU

    2013-12-01

    Full Text Available Current researches were carried out with the goal to quantisize the lost from the weaning to early gestation at the sows housed in open pen gestation. In this trail we tested two pen types, different not only by size, but also by feeders’ emplacement. The main reproduction indicators that we calculated until the 28 gestation day were the proportion of sows in heat after weaning, the weaning to estrus interval and the gestation rates. The weaning to estrus interval was about 4 to 7 days, most sows were in heat in the day 5 and 6 days after weaning. The percent of heat detection after weaning was 71.42% for the small pens and 70.71% for the big pens (differences statistically non significant, chi test value was 0.983. The gestation rate at 28 days after insemination was 91.62% for the small pens and 94.72% for the large pens (chi test value 0,959, statistically non significant differences. The overpopulation for heat induction and after that chipping animals together in those pens, show that the lost are up to 40.47%, between weaning – day 28 of gestation.

  6. Tono-Pen XL tonometry during application of a suction ring in rabbits

    Directory of Open Access Journals (Sweden)

    Kounis Georgios A

    2008-07-01

    Full Text Available Abstract Background The purpose of this study is to evaluate the use of Tono-Pen XL in measuring IOP during the application of a suction ring in rabbit eyes with manometrically controlled IOP. Methods Tono-Pen XL was calibrated against direct manometry in 10 rabbit eyes. A suction ring was then applied in 4 rabbit eyes and the IOP was determined manometrically during suction ring application at 350 mmHg vacuum pressure. Finally, in 6 catheterized rabbit eyes the IOP was measured with Tono-Pen XL during suction ring application at suction vacuum from 350 to 650 mmHg, while keeping actual IOP stable at 30 mmHg and 60 mmHg. Results Linear regression analysis revealed that the Tono-pen XL was reliable for IOPs between 10 and 70 mmHg (R2 = 0.9855. Direct manometry during suction ring application showed no statistically significant variation of Tono-Pen XL readings when the incanulation manometry intraocular pressure changed from 30 mmHg to 60 mmHg and no statistically significant correlation between suction vacuum and IOP measurements. Conclusion Tono-Pen XL measurements are unreliable during the application of a suction ring on living rabbit eyes even when the actual IOP is forced to be within the validated range of Tono-Pen XL measurements. This inaccuracy is probably related to altered corneal and scleral geometry and stress.

  7. 智能音乐喷泉的多模型控制%On Multi-model Control of Intelligent Music Fountain

    Institute of Scientific and Technical Information of China (English)

    赵伟

    2016-01-01

    By the fuzzy c-means algorithm,a large amount of data classification are extracted and classified from music files to build a multiple model set of music emotion characteristics;after the expected music feature model is set,multiple control strategies are designed based on multiple music emotion model types of the model set,and the corresponding fountain matrix is worked out.Each MIDI music data cycle will be matched with the model set by fuzzy recognition,and the corresponding matrix fountain will be selected for matrix fountain until the expected music feature model is produced.This control method is implemented in the music fountain model,and has achieved a good control effect.%运用模糊c均值聚类算法,将根据MIDI音乐文件提取的数据进行分类,建立多模型音乐情感特征模型集;设定期望音乐特征模型,并根据音乐情感模型集中的多种类型,设计多种音乐喷泉控制策略,求出相应的喷泉矩阵。每一个MIDI音乐数据周期,采用模糊识别的方法把获得的实时音乐数据与模型集相匹配,进而采用相应的喷泉控制矩阵进行控制,直至达到期望音乐情感特征模型。本控制方法在音乐喷泉模型上得到实施,取得很好的控制效果。

  8. Sensitive CO and 13CO survey of water fountain stars. Detections towards IRAS 18460-0151 and IRAS 18596+0315

    CERN Document Server

    Rizzo, J R; Miranda, L F; Osorio, M; Suarez, O; Duran-Rojas, M C

    2013-01-01

    Water fountain stars represent a stage between the asymptotic giant branch (AGB) and planetary nebulae phases, when the mass loss changes from spherical to bipolar. These types of evolved objects are characterized by high-velocity jets in the 22 GHz water maser emission. We surveyed the CO and 13CO line emission towards a sample of ten water fountain stars through observing the J=1-0 and 2-1 lines of CO and 13CO, using the 30m IRAM radio telescope at Pico Veleta. All the water fountains visible from the observatory were surveyed. Most of the line emission arises from foreground or background Galactic clouds, and we had to thoroughly analyse the spectra to unveil the velocity components related to the stars. In two sources, IRAS 18460-0151 and IRAS 18596+0315, we identified wide velocity components with a width of 35-40 km/s that are centred at the stellar velocities. These wide components can be associated with the former AGB envelope of the progenitor star. A third case, IRAS 18286-0959, is reported as tenta...

  9. Analysis on Causes of Electrical Shock Accident of Fountain%喷水池电击事故起因简析

    Institute of Scientific and Technical Information of China (English)

    王厚余

    2012-01-01

    Electrical shock accident of fountain occurs frequently in China. Electrical equipments with a voltage of 220 V and above should be used for fountain and over-high voltage will result in electrical shock accident underwater. The author believes that different from that above ground, the electrical shock accident of fountain is mainly caused by underground voltage gradient or electric field. Therefore, relevant analysis is conducted and key points to prevent electrical shock accident during electrical design under the current conditions in China are presented.%我国喷水池电击事故屡有发生。喷水池内电气设备需采用220V及以上电压,过高电压在水下很易引发电击事故。作者认为喷水池内电击事故的发生与地面上不同,它主要由水下电压梯度或电场引起。故对此进行分析,并提出在我国现时条件下喷水池电气设计中防电击的要点。

  10. Estimating eruption temperature from thermal emission spectra of lava fountain activity in the Erta'Ale (Ethiopia) volcano lava lake: Implications for observing Io's volcanoes

    Science.gov (United States)

    Davies, Ashley G.; Keszthelyi, Laszlo P.; McEwen, Alfred S.

    2011-01-01

    We have analysed high-spatial-resolution and high-temporal-resolution temperature measurements of the active lava lake at Erta'Ale volcano, Ethiopia, to derive requirements for measuring eruption temperatures at Io's volcanoes. Lava lakes are particularly attractive targets because they are persistent in activity and large, often with ongoing lava fountain activity that exposes lava at near-eruption temperature. Using infrared thermography, we find that extracting useful temperature estimates from remote-sensing data requires (a) high spatial resolution to isolate lava fountains from adjacent cooler lava and (b) rapid acquisition of multi-color data. Because existing spacecraft data of Io's volcanoes do not meet these criteria, it is particularly important to design future instruments so that they will be able to collect such data. Near-simultaneous data at more than two relatively short wavelengths (shorter than 1 μm) are needed to constrain eruption temperatures. Resolving parts of the lava lake or fountains that are near the eruption temperature is also essential, and we provide a rough estimate of the required image scale.

  11. Molecular investigations of PenA-mediated beta-lactam resistance inBurkholderia pseudomallei

    Directory of Open Access Journals (Sweden)

    Drew A Rholl

    2011-07-01

    Full Text Available Burkholderia pseudomallei is the etiological agent of melioidosis. Because of the bacterium’s intrinsic resistance and propensity to establish latent infections, melioidosis therapy is complicated and prolonged. Newer generation b-lactams, specifically ceftazidime, are used for acute phase therapy, but resistance to the drugs has been observed. The chromosomally-encoded penA gene encodes a putative twin arginine translocase (TAT-secreted b-lactamase, and penA mutations have been implicated in ceftazidime resistance in clinical isolates. However, the role of PenA in resistance has not yet been systematically studied in isogenetic B. pseudomallei mutant backgrounds. We investigated the effects of penA deletion, point mutations, and up-regulation, as well as tat operon deletion and PenA TAT signal sequence mutations. These experiments were made possible by employing a B. pseudomallei strain that is excluded from Select Agent regulations. Deletion of penA significantly (>4-fold reduced the susceptibility to six of the nine b-lactams tested and >16-fold for ampicillin, amoxicillin and carbenicillin. Over-expression of penA by single-copy, chromosomal expression of the gene under control of the inducible Ptac promoter, increased resistance levels for all b-lactams tested 2- to 10-fold. Recreation of the C69Y and P167S PenA amino acid substitutions previously observed in resistant clinical isolates increased resistance to ceftazidime by >85 and 5 to 8-fold, respectively. Similarly, a S72F substitution resulted in a 4-fold increase in resistance to amoxicillin + clavulanic acid. Susceptibility assays with PenA TAT signal sequence and tatABC mutants, as well as Western blot analysis, confirmed that PenA is a TAT secreted enzyme and not periplasmic but associated with the spheroplastic cell fraction. Lastly, we determined that two LysR-family regulators encoded by genes adjacent to penA do not play a role in transcriptional regulation of pen

  12. Chitinolytic Bacteria-Assisted Conversion of Squid Pen and Its Effect on Dyes and Pigments Adsorption

    OpenAIRE

    Tzu-Wen Liang; Bo-Chang Lo; San-Lang Wang

    2015-01-01

    The aim of this work was to produce chitosanase by fermenting from squid pen, and recover the fermented squid pen for dye removal by adsorption. One chitosanase induced from squid pen powder (SPP)-containing medium by Bacillus cereus TKU034 was purified in high purification fold (441) and high yield of activity recovery (51%) by ammonium sulfate precipitation and combined column chromatography. The SDS-PAGE results showed its molecular mass to be around 43 kDa. The TKU034 chitosanase used for...

  13. Nest building and posture changes and activity budget of gilts housed in pens and crates

    DEFF Research Database (Denmark)

    Andersen, Inger Lise; Vasdal, Guro; Pedersen, Lene Juul

    2014-01-01

    was born until 8 h after the birth of the first piglet. There was no significant effect of the sows breeding value on any of the sow behaviours. Sows housed in pens spent significantly more time nest building than crated sows from 4 to 12 h prepartum (P ... for the lack of space in the crate compared to the pens. Sows in pens spent more time nest building from 4 to 12 h post partum compared to crated sows, and crated sows showed more behaviours related to frustration and restlessness....

  14. Update on PEN: A Precise Measurement of the π+ ->e+ ν(γ) Decay

    Science.gov (United States)

    Frlez, Emil; PEN Collaboration

    2016-09-01

    The PEN experiment acquired an ensemble of 2 . 1 .107 π+ and 2 . 8 .108 μ+ decays at rest during 2008-2010 data collection at the Paul Scherrer Institute, Switzerland. The PEN detector comprises a non-magnetic 3 π solid-angle pure 240-module CsI calorimeter, supplemented with mini-TPC beam particle tracking, beam degrader and active target counters, 20-stave segmented plastic hodoscope and two concentric MWPCs for charged particle tracking and discrimination. We present an update of the status of the PEN data analysis, and of the associated systematic effects. Work supported by NSF Grants PHY-1307328, 1614839 and others.

  15. Cusp Ion Fountain Observations from the e-POP Suprathermal Electron Imager (SEI) with DMSP and RISR-N conjunctions

    Science.gov (United States)

    Shen, Y.; Knudsen, D. J.; Burchill, J. K.; Howarth, A. D.; Yau, A. W.; Redmon, R. J.

    2015-12-01

    Low-energy (regions are investigated using conjunctions of the Enhanced Polar Outflow Probe (e-POP) satellite, the Resolute Bay Incoherent Scatter Radar (RISR-N) and the DMSP satellites in June 2014. e-POP encountered the cusp/cleft ion fountain at 10-14 MLT and around 1000 km altitude during these experiments. Such intermediate-altitude observations of ion upflow have been sampled only rarely by previous satellite missions and ground-based radars. The Suprathermal Electron Imager (SEI) onboard e-POP measures two-dimensional ion distribution functions with a frame rate of 100 images per second, from which, high-precision energy and angle information of entering ions can be inferred. Large field-aligned ion bulk flow velocities (2.5 km/s) are estimated from the angle information with a resolution of the order of 25 m/s. The ion velocities were, in general, upward in the cusp region and downward in the polar cap region. The ion temperatures have been resolved by investigating the slop shape of the distribution function. It has been found that only weak perpendicular (to B) heating occurred during these events, which when combined with the simultaneous soft electron precipitation observed by the DMSP SSJ/4 instrument, suggests that ambipolar electric fields play a dominant role in accelerating ions upward at and below 1000 km. Also, structured DC field-aligned currents derived from the magnetic field instrument (MGF) onboard e-POP are found to be well-correlated with upflow velocities. In addition, ion composition information is available from e-POP's ion mass spectrometer (IRM). Oxygen ions (O+) were found to dominate (85%) in the identified events, accompanied by a small fraction (15%) of hydrogen ions (H+) and helium ions (He+). We will compare these in situ measurements with RISR-N observations in order to further our understanding of the mechanisms responsible for, and the three-dimensional structure of, the cusp ion fountain. Acknowledgement: This research is

  16. Phase-space properties of magneto-optical traps utilising micro-fabricated gratings

    CERN Document Server

    McGilligan, James P; Riis, Erling; Arnold, Aidan S

    2015-01-01

    We have used diffraction gratings to simplify the fabrication, and dramatically increase the atomic collection efficiency, of magneto-optical traps using micro-fabricated optics. The atom number enhancement was mainly due to the increased beam capture volume, afforded by the large area (4cm^2) shallow etch (200nm) binary grating chips. Here we provide a detailed theoretical and experimental investigation of the on-chip magneto-optical trap temperature and density in four different chip geometries using 87Rb, whilst studying effects due to MOT radiation pressure imbalance. With optimal initial MOTs on two of the chips we obtain both large atom number (2x10^7) _and_ sub-Doppler temperatures (50uK) after optical molasses.

  17. A System for Trapping Barium Ions in a Microfabricated Surface Trap

    Science.gov (United States)

    Zhou, Zichao; Wright, John; Graham, Richard; Sakrejda, Tomasz; Chen, Bing; Blinov, Boris; Musiqc Team

    2013-05-01

    We have developed a vacuum chamber and control system for rapid testing and development of microfabricated surface traps. Barium ions have been successfully cooled and trapped in this system. The dark lifetime of a single 138Ba + in this trap is up to 30s. And we can shuttle of ions at rate of 8 cm/s between different potential zones. Our system uses a modular design and is based on an in-vacuum PCB with integrated filters. Control of up to 96 DC electrodes is achieved with an update rate of 20 kHz using a custom FPGA based control system. Collection of fluorescence light over a numerical aperture of 0.28 has been achieved. This work is supported by IAPRA.

  18. Microfabricated DNA analysis system. Semi-annual report, August 1993--January 1994

    Energy Technology Data Exchange (ETDEWEB)

    Northrup, M.A.

    1994-01-01

    We are miniaturizing instrumentation for the polymerase chain reaction (PCR) -- a bioanalytical technique that amplifies target sections of DNA through thermal cycling. This report focuses on delineating reaction chamber, design parameters through computer modeling and infrared imaging. We have also continued micro-chamber-based PCR experiments and have successfully amplified three different targets from two different biological sources. Specifically, we have amplified DNA from {beta}-globin (a subunit of hemoglobin), and two different-sized targets from the Human Immunodeficiency Virus (HIV). These experiments were performed in newly-designed chambers. Reaction chambers are also being designed with detection in mind, specifically for the detection of fluorescent DNA labels. Finally, some new developments in PCR technology are described as they represent potential biological diagnostics to be evaluated in microfabricated DNA analysis systems.

  19. Reliable transport through a microfabricated X-junction surface-electrode ion trap

    Science.gov (United States)

    Wright, Kenneth; Amini, Jason M.; Faircloth, Daniel L.; Volin, Curtis; Doret, S. Charles; Hayden, Harley; Pai, C.-S.; Landgren, David W.; Denison, Douglas; Killian, Tyler; Slusher, Richart E.; Harter, Alexa W.

    2013-03-01

    We report the design, fabrication and characterization of a microfabricated surface-electrode ion trap that supports controlled transport through the two-dimensional intersection of linear trapping zones arranged in a 90° cross. The trap is fabricated with very large scalable integration techniques which are compatible with scaling to a large quantum information processor. The shape of the radio-frequency electrodes is optimized with a genetic algorithm to reduce axial pseudopotential barriers and minimize ion heating during transport. Seventy-eight independent dc control electrodes enable fine control of the trapping potentials. We demonstrate reliable ion transport between junction legs and determine the rate of ion loss due to transport. Doppler-cooled ions survive more than 105 round-trip transits between junction legs without loss and more than 65 consecutive round trips without laser cooling.

  20. Development and Studies of Novel Microfabricated Radiation Hard Scintillation Detectors With High Spatial Resolution

    CERN Document Server

    Mapelli, A; Haguenauer, M; Jiguet, S; Renaud, P; Vico Triviño, N

    2011-01-01

    A new type of scintillation detector is being developed with standard microfabrication techniques. It consists of a dense array of scintillating waveguides obtained by coupling microfluidic channels filled with a liquid scintillator to photodetectors. Easy manipulation of liquid scintillators inside microfluidic devices allow their flushing, renewal, and exchange making the active medium intrinsically radiation hard. Prototype detectors have been fabricated by photostructuration of a radiation hard epoxy resin (SU-8) deposited on silicon wafers and coupled to a multi-anode photomultiplier tube (MAPMT) to read-out the scintillation light. They have been characterized by exciting the liquid scintillator in the 200 micrometers thick microchannels with electrons from a 90Sr yielding approximately 1 photoelectron per impinging Minimum Ionizing Particle (MIP). These promising results demonstrate the concept of microfluidic scintillating detection and are very encouraging for future developments.

  1. Enhanced sensitivity of a microfabricated resonator using a graphene-polystyrene bilayer membrane

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Minhyuk; Lee, Eunho; Cho, Kilwon; Jeon, Sangmin, E-mail: jeons@postech.ac.kr [Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang (Korea, Republic of)

    2014-08-18

    A graphene layer was synthesized using chemical vapor deposition methods and a polystyrene solution was spin-cast onto the graphene film. The graphene-polystyrene bilayer membrane was attached between the two tines of a microfabricated quartz tuning fork (QTF). The modulus of the graphene-polystyrene bilayer was measured to be twice that of a pristine polystyrene membrane. Exposure of the membrane-coated QTF to ethanol vapor decreased the resonance frequency of the microresonator. The bilayer membrane-coated QTF produced a frequency change that was three times the change obtained using a polystyrene membrane-coated QTF, with a lower degree of degradation in the Q factor. The limit of detection of the bilayer membrane-coated QTF to ethanol vapor was determined to be 20 ppm.

  2. Nucleate pool boiling investigation on a silicon test section with micro-fabricated cavities

    Energy Technology Data Exchange (ETDEWEB)

    Sanna, A.; Kenning, D.B.R.; Karayiannis, T.G. [Brunel University, Uxbridge (United Kingdom); Hutter, C.; Sefiane, K. [University of Edinburgh (United Kingdom); Nelson, R.A. [Los Alamos National Laboratory, Los Alamos, NM (United States)

    2009-07-01

    The basic mechanisms of nucleate boiling are still not completely understood, in spite of the many numerical and experimental studies dedicated to the topic. The use of a hybrid code allows reasonable computational times for simulations of a solid plate with a large population of artificial micro-cavities with fixed distribution. This paper analyses the guidelines for the design, through numerical simulations, of the location and sizes of micro-fabricated cavities on a new silicon test section immersed in FC-72 at the saturation temperature for different pressures with an imposed heat flux applied at the back of the plate. Particular focus is on variations of wall temperature around nucleation sites. (author)

  3. Microfabrication, surface modification, and laser guidance techniques to create a neuron biochip

    Institute of Scientific and Technical Information of China (English)

    Russell Kirk Pirlo; Xiang Peng; Xiaocong Yuan; Bruce Zhi Gao

    2008-01-01

    In this report we illustrate our application of soft lithography-based microfabrication, surface modification, and our unique laser cell-patterning system toward the creation of neuron biochips. We deposited individual forebrain neurons from Day 7 embryonic chicks into two rows of eight in a silicon microstructure aligned over a microelectrode array (MEA). The polydimethylsiloxane (PDMS) membrane with microstructures to confine cells and guide network connectivity was aligned to the electrodes ofa MEA. Both the MEA and the PDMS membrane were treated with O2 plasma, Poly-L-Lysine, and Laminin to aid in cell attachment and survival. The primary advantage of our process is that it is quicker and simpler than previous cell-placement methods and may make highly defined neuronal network biochips more practical

  4. A Microfabricated Segmented-Involute-Foil Regenerator for Enhancing Reliability and Performance of Stirling Engines

    Science.gov (United States)

    Ibrahim, Mounir; Danila, Daniel; Simon, Terrence; Mantell, Susan; Sun, Liyong; Gadeon, David; Qiu, Songgang; Wood, Gary; Kelly, Kevin; McLean, Jeffrey

    2007-01-01

    An actual-size microfabricated regenerator comprised of a stack of 42 disks, 19 mm diameter and 0.25 mm thick, with layers of microscopic, segmented, involute-shaped flow channels was fabricated and tested. The geometry resembles layers of uniformly-spaced segmented-parallel-plates, except the plates are curved. Each disk was made from electro-plated nickel using the LiGA process. This regenerator had feature sizes close to those required for an actual Stirling engine but the overall regenerator dimensions were sized for the NASA/Sunpower oscillating-flow regenerator test rig. Testing in the oscillating-flow test rig showed the regenerator performed extremely well, significantly better than currently used random-fiber material, producing the highest figures of merit ever recorded for any regenerator tested in that rig over its approximately 20 years of use.

  5. The Role of Microfabrication and Nanotechnology in the Development of Microbial Fuel Cells

    KAUST Repository

    Rojas, Jhonathan Prieto

    2015-09-23

    Innovative solutions are paramount to the identification and development of alternative energy resources, specifically for the production of potable water. Microbial fuel cells (MFCs) are a trending emerging technology that promises green energy production while simultaneously treating wastewater. At present, several research efforts are working towards determining which bacteria, fuels, and materials are optimal for developing the most efficient MFCs; microsized MFCs have a key role in this goal. Therefore, in this Review, we summarize recent microfabrication techniques for building microsized cells and elaborate on their advantages and the challenges that need to be overcome. We will then focus on the integration of nanomaterials into MFCs and finish with an overview on the challenges to scale up MFCs and potential uses for these miniature cells.

  6. Solid state synthesis of chitosan and its unsaturated derivatives for laser microfabrication of 3D scaffolds

    Science.gov (United States)

    Akopova, T. A.; Demina, T. S.; Bagratashvili, V. N.; Bardakova, K. N.; Novikov, M. M.; Selezneva, I. I.; Istomin, A. V.; Svidchenko, E. A.; Cherkaev, G. V.; Surin, N. M.; Timashev, P. S.

    2015-07-01

    Chitosans with various degrees of deacetylation and molecular weights and their allyl substituted derivatives were obtained through a solvent-free reaction under shear deformation in an extruder. Structure and physical-chemical analysis of the samples were carried out using nuclear magnetic resonance (NMR), ultraviolet (UV) and infrared radiation (IR) spectroscopy. Photosensitive materials based on the synthesized polymers were successfully used for microfabrication of 3D well-defined architectonic structures by laser stereolithography. Study on the metabolic activity of NCTC L929 cultured in the presence of the cured chitosan extracts indicates that the engineered biomaterials could support adhesion, spreading and growth of adherent-dependent cells, and thus could be considered as biocompatible scaffolds.

  7. Reliable transport through a microfabricated X-junction surface-electrode ion trap

    CERN Document Server

    Wright, Kenneth; Faircloth, Daniel L; Volin, Curtis; Doret, S Charles; Hayden, Harley; Pai, C-S; Landgren, David W; Denison, Douglas; Killian, Tyler; Slusher, Richart E; Harter, Alexa W

    2012-01-01

    We report the design, fabrication, and characterization of a microfabricated surface-electrode ion trap that supports controlled transport through the two-dimensional intersection of linear trapping zones arranged in a ninety-degree cross. The trap is fabricated with very-large-scalable-integration (VLSI) techniques which are compatible with scaling to a larger quantum information processor. The shape of the radio-frequency (RF) electrodes is optimized with a genetic algorithm to minimize axial pseudopotential barriers and to minimize ion heating during transport. Seventy-eight independent DC control electrodes enable fine control of the trapping potentials. We demonstrate reliable ion transport between junction legs, trapping of ion chains with nearly-equal spacing in one of the trap's linear sections, and merging and splitting ions from these chains. Doppler-cooled ions survive more than 10^5 round-trip transits between junction legs without loss and more than sixty-five consecutive round trips without lase...

  8. Microfabrication technology for large LEKID arrays : from NIKA2 to future applications

    CERN Document Server

    Goupy, J; Benoit, A; Bourrion, O; Calvo, M; Catalano, A; Coiffard, G; Hoarau, C; Leclercq, S; Sueur, H Le; Macias-Perez, J; Monfardini, A; Peck, I; Schuster, K

    2016-01-01

    The Lumped Element Kinetic Inductance Detectors (LEKID)demonstrated full maturity in the NIKA (New IRAM KID Arrays)instrument. These results allow directly comparing LEKID performance with other competing technologies (TES, doped silicon) in the mm and sub-mm range. A continuing effort is ongoing to improve the microfabrication technologies and concepts in order to satisfy the requirements of new instruments. More precisely, future satellites dedicated to CMB (Cosmic Microwave Background) studies will require the same focal plane technology to cover, at least, the frequency range of 60 to 600 GHz. Aluminium LEKID developed for NIKA have so far demonstrated, under real telescope conditions, performance approaching photon-noise limitation in the band 120-300 GHz. By implementing superconducting bi-layers we recently demonstrated LEKID arrays working in the range 80-120 GHz and with sensitivities approaching the goals for CMB missions. NIKA itself (350 pixels) is followed by a more ambitious project requiring se...

  9. Attachment of DNA to microfabricated arrays with self-assembled monolayer

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Guojun; Tanii, Takashi; Miyake, Takeo; Funatsu, Takashi; Ohdomari, Iwao

    2004-10-01

    A novel approach of fabricating sub-10-{mu}m patterns on silicon surfaces by electron beam (EB) lithography for attachment of oligonucleotides was described. The shape of the microfabricated arrays was observed to be regular by optical microscopy. An octadecyltrimethoxysilane (ODS) monolayer was deposited on the regions outside the patterned areas to minimize the nonspecific binding of biomolecules. Cy 5-labeled target DNA was hybridized to both complementary and noncomplementary oligonucleotides that were covalently anchored to micropatterns. As a result, the micropatterns where specific binding occurred show strong signals, whereas no signals are observed in the case of nonspecific binding. These data indicate that miniature micro- and nano-arrays will find applications in biochips and biosensors.

  10. Laser micro-fabrication of concave, low-roughness features in silica

    Directory of Open Access Journals (Sweden)

    D. Hunger

    2012-03-01

    Full Text Available We describe a micro-fabrication method to create concave features with ultra-low roughness in silica, either on optical fibers or on flat substrates. The machining uses a single CO2 laser pulse train. Parameters are chosen such that evaporation removes material while a low-viscosity melt layer produces excellent surface quality. A surface roughness σ ∼ 0.2 nm is regularly obtained. The concave depressions are near-spherical close to the center with radii of curvature between 20 and 2000 μm. The method allows fabrication of low-scatter micro-optical devices such as mirror substrates for high-finesse cavities or negative lenses on fiber tips, extending the range of micro-optical components.

  11. Microfabricated rankine cycle steam turbine for power generation and methods of making the same

    Science.gov (United States)

    Frechette, Luc (Inventor); Muller, Norbert (Inventor); Lee, Changgu (Inventor)

    2009-01-01

    In accordance with the present invention, an integrated micro steam turbine power plant on-a-chip has been provided. The integrated micro steam turbine power plant on-a-chip of the present invention comprises a miniature electric power generation system fabricated using silicon microfabrication technology and lithographic patterning. The present invention converts heat to electricity by implementing a thermodynamic power cycle on a chip. The steam turbine power plant on-a-chip generally comprises a turbine, a pump, an electric generator, an evaporator, and a condenser. The turbine is formed by a rotatable, disk-shaped rotor having a plurality of rotor blades disposed thereon and a plurality of stator blades. The plurality of stator blades are interdigitated with the plurality of rotor blades to form the turbine. The generator is driven by the turbine and converts mechanical energy into electrical energy.

  12. Laser micro-fabrication of concave, low-roughness features in silica

    CERN Document Server

    Hunger, David; Barbour, Russell J; Warburton, Richard J; Reichel, Jakob

    2011-01-01

    We describe a micro-fabrication method to create concave features with ultra-low surface roughness in silica, either on the end facets of optical fibers or on flat substrates. The machining uses a single focused CO2 laser pulse. Parameters are chosen such that material is removed by thermal evaporation while simultaneously producing excellent surface quality by surface tension-induced movement in a low-viscosity melt layer. A surface roughness {\\sigma}~0.2nm is regularly obtained. The concave depressions are near-spherical close to the center with radii of curvature between 20 and 2000{\\mu}m. The method allows the fabrication of low-scatter micro-optical devices such as mirror substrates for high-finesse cavities or negative lenses on the tip of optical fibers, extending the range of micro-optical components.

  13. Characterization of spin pumping effect in Permalloy/Cu/Pt microfabricated lateral devices

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Tatsuya, E-mail: tyamamoto@imr.tohoku.ac.jp; Seki, Takeshi; Takanashi, Koki [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); Ono, Shimpei [Central Research Institute of Electric Power Industry, Tokyo 201-8511 (Japan)

    2014-05-07

    We studied ferromagnetic resonance (FMR) for microfabricated lateral devices consisting of a Permalloy (Py) rectangular element and a Pt nano-element bridged by a Cu wire, which were located on a coplanar waveguide. A change in the resonance linewidth (Δf) was observed in the FMR spectra when the distance between Py and Pt (d) was varied. For devices with d < 400 nm, Δf definitely increased, suggesting the enhancement of the Gilbert damping constant (α). We discussed a possible reason for the this enhancement taking into account the increase in the efficiency of spin pumping into Cu due to the spin absorption of the attached Pt.

  14. A forensic laboratory tests the Berkeley microfabricated capillary array electrophoresis device.

    Science.gov (United States)

    Greenspoon, Susan A; Yeung, Stephanie H I; Johnson, Kelly R; Chu, Wai K; Rhee, Han N; McGuckian, Amy B; Crouse, Cecelia A; Chiesl, Thomas N; Barron, Annelise E; Scherer, James R; Ban, Jeffrey D; Mathies, Richard A

    2008-07-01

    Miniaturization of capillary electrophoresis onto a microchip for forensic short tandem repeat analysis is the initial step in the process of producing a fully integrated and automated analysis system. A prototype of the Berkeley microfabricated capillary array electrophoresis device was installed at the Virginia Department of Forensic Science for testing. Instrument performance was verified by PowerPlex 16 System profiling of single source, sensitivity series, mixture, and casework samples. Mock sexual assault samples were successfully analyzed using the PowerPlex Y System. Resolution was assessed using the TH01, CSF1PO, TPOX, and Amelogenin loci and demonstrated to be comparable with commercial systems along with the instrument precision. Successful replacement of the Hjerten capillary coating method with a dynamic coating polymer was performed. The accurate and rapid typing of forensic samples demonstrates the successful technology transfer of this device into a practitioner laboratory and its potential for advancing high-throughput forensic typing.

  15. Enhanced sensitivity of a microfabricated resonator using a graphene-polystyrene bilayer membrane

    Science.gov (United States)

    Yun, Minhyuk; Lee, Eunho; Cho, Kilwon; Jeon, Sangmin

    2014-08-01

    A graphene layer was synthesized using chemical vapor deposition methods and a polystyrene solution was spin-cast onto the graphene film. The graphene-polystyrene bilayer membrane was attached between the two tines of a microfabricated quartz tuning fork (QTF). The modulus of the graphene-polystyrene bilayer was measured to be twice that of a pristine polystyrene membrane. Exposure of the membrane-coated QTF to ethanol vapor decreased the resonance frequency of the microresonator. The bilayer membrane-coated QTF produced a frequency change that was three times the change obtained using a polystyrene membrane-coated QTF, with a lower degree of degradation in the Q factor. The limit of detection of the bilayer membrane-coated QTF to ethanol vapor was determined to be 20 ppm.

  16. A microfabricated fringing field capacitive pH sensor with an integrated readout circuit

    Energy Technology Data Exchange (ETDEWEB)

    Arefin, Md Shamsul, E-mail: md.arefin@monash.edu; Redoute, Jean-Michel; Rasit Yuce, Mehmet [Electrical and Computer Systems Engineering, Monash University, Melbourne (Australia); Bulut Coskun, M.; Alan, Tuncay; Neild, Adrian [Mechanical and Aerospace Engineering, Monash University, Melbourne (Australia)

    2014-06-02

    This work presents a microfabricated fringe-field capacitive pH sensor using interdigitated electrodes and an integrated modulation-based readout circuit. The changes in capacitance of the sensor result from the permittivity changes due to pH variations and are converted to frequency shifts using a crossed-coupled voltage controlled oscillator readout circuit. The shift in resonant frequency of the readout circuit is 30.96 MHz for a change in pH of 1.0–5.0. The sensor can be used for the measurement of low pH levels, such as gastric acid, and can be integrated with electronic pills. The measurement results show high repeatability, low noise, and a stable output.

  17. Metal-Organic Framework Thin Films as Stationary Phases in Microfabricated Gas-Chromatography Columns.

    Energy Technology Data Exchange (ETDEWEB)

    Read, Douglas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sillerud, Colin Halliday [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-01-01

    The overarching goal of this project is to integrate Sandia's microfabricated gas-chromatography ( GC) columns with a stationary phase material that is capable of retaining high-volatility chemicals and permanent gases. The successful integration of such a material with GCs would dramatically expand the repertoire of detectable compounds for Sandia's various microanalysis systems. One such promising class of candidate materials is metal-organic frameworks (MOFs). In this report we detail our methods for controlled deposition of HKUST-1 MOF stationary phases within GC columns. We demonstrate: the chromatographic separation of natural gas; a method for determining MOF film thickness from chromatography alone; and the first-reported GC x GC separation of natural gas -- in general -- let alone for two disparate MOF stationary phases. In addition we determine the fundamental thermodynamic constant for mass sorption, the partition coefficient, for HKUST-1 and several light hydrocarbons and select toxic industrial chemicals.

  18. Detection of functional groups and antibodies on microfabricated surfaces by confocal microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Nashat, A.H.; Ferrari, M. [Univ. of California, Berkeley, CA (United States); Moronne, M. [Lawrence Berkeley National Lab., CA (United States)

    1998-10-20

    Fluorescence confocal microscopy was used to characterize micron-sized microfabricated silicon particles and planar oxides surfaces after silanization and immobilization of IgG antibody. Surfaces treated with amino- and mercaptosilanes were tested by the presence of amine and sulfhydryl groups by labeling with specific fluorescein probes. In addition, human antibody (IgG) was immobilized to the thiol-coated microparticles using the heterobifunctional crosslinker succinimidyl 4-(N-maleimidolmthyl)-cyclohexane-1-carboxylate. Estimates of the surface density of IgG were consistent with 8.3% of a monolayer of covalently-bound antibody. Confocal images confirmed uniform layers of both silanes and antibodies on the microparticles. The sensitivity limit for the confocal measurements was determined to be as low as 1.5 x 10{sup {minus}5} fluors per nm{sup 2}.

  19. Microfabrics in carbonate mylonites along a large-scale shear zone (Helvetic Alps)

    Science.gov (United States)

    Ebert, Andreas; Herwegh, Marco; Evans, Brian; Pfiffner, Adrian; Austin, Nick; Vennemann, Torsten

    2007-11-01

    Carbonate mylonites with varying proportions of second-phase minerals were collected at positions of increasing metamorphic grade along the basal thrust of the Morcles nappe (Helvetic nappes, Switzerland). Variations of temperature, stress, and strain rate, changes in chemistry of solid and fluid phases, and differing degrees of strain localization and annealing were tracked by measuring the shapes, mean sizes, and size distributions of both matrix and second-phase grains, as well as crystal preferred orientation (CPO) of the matrix. Field structures suggest that strain rate was constant along the fault. The mean and distribution of the calcite grain sizes were affected most profoundly by temperature: Increased temperature, presumably accompanied by decreased stress, correlated with larger mean sizes and wider size distributions. At a given location, the matrix grains in mylonites with more second-phase particles are, on average, smaller, have narrower size distributions, and have more elongate shapes. For example, mylonites with 50 vol.% of second phases have matrix grain sizes half that of pure mylonites. Changes in calcite chemistry and the presence of synkinematic fluids seemed to influence microfabric only weakly. Temporal variations in conditions, such as exhumation-induced cooling, apparently provoke changes in temperature, stress, and strain rate along the nappe. These changes result in further strain localization during retrograde conditions and cause the grain size to be reduced by an additional 50%. The matrix CPO strengthens with increasing temperature or strain, but weakens and rotates with increasing second-phase content. These fabric changes suggest differing rates of grain growth, grain size reduction, and development of CPO owing to variations in the deformation conditions and, perhaps, mechanisms. To interpret natural mylonite structures or to extrapolate mechanical data to natural situations requires careful characterization of the microfabric

  20. Rapid microfabrication of transparent materials using a filamented beam of the IR femtosecond laser

    Science.gov (United States)

    Butkus, S.; Paipulas, D.; Viburys, Ž.; Alesenkov, A.; Gaižauskas, E.; KaškelytÄ--, D.; Barkauskas, M.; Sirutkaitis, V.

    2014-03-01

    Glass drilling and welding applications realized with the help of femtosecond lasers attract industrial attention , however, desired tasks may require systems employing high numerical aperture (NA) focusing conditions, low repetition rate lasers and complex fast motion translation stages. Due to the sensitivity of such systems, slight instabilities in parameter values can lead to crack formations, severe fabrication rate decrement and poor quality overall results. A microfabrication system lacking the stated disadvantages was constructed and demonstrated in this report. An f-theta lens was used in combination with a galvanometric scanner, in addition, a water pumping system that enables formation of water films of variable thickness in real time on the samples. Water acts as a medium for filament formation, which in turn decreases the focal spot diameter and increases fluence and axial focal length . This article demonstrates the application of a femtosecond (280fs) laser towards two different micromachining techniques: rapid cutting and welding of transparent materials. Filament formation in water gives rise to strong ablation at the surface of the sample, moreover, the water, surrounding the ablated area, adds increased cooling and protection from cracking. The constructed microfabrication system is capable of drilling holes in thick soda-lime and hardened glasses. The fabrication time varies depending on the diameter of the hole and spans from a few to several hundred seconds. Moreover, complex-shape fabrication was demonstrated. Filament formation at the interface of two glass samples was also used for welding applications. By varying repetition rate, scanning speed and focal position optimal conditions for strong glass welding via filamentation were determined.

  1. Psychometric Assessment of the Injection Pen Assessment Questionnaire (IPAQ: measuring ease of use and preference with injection pens for human growth hormone

    Directory of Open Access Journals (Sweden)

    Pleil Andreas M

    2012-10-01

    Full Text Available Abstract Purpose To examine the psychometric properties of the Injection Pen Assessment Questionnaire (IPAQ including the following: 1 item and scale characteristics (e.g., frequencies, item distributions, and factor structure, 2 reliability, and 3 validity. Methods Focus groups and one-on-one dyad interviews guided the development of the IPAQ. The IPAQ was subsequently tested in 136 parent–child dyads in a Phase 3, 2-month, open-label, multicenter trial for a new Genotropin® disposable pen. Factor analysis was performed to inform the development of a scoring algorithm, and reliability and validity of the IPAQ were evaluated using the data from this two months study. Psychometric analyses were conducted separately for each injection pen. Results Confirmatory factor analysis provides evidence supporting a second order factor solution for four subscales and a total IPAQ score. These factor analysis results support the conceptual framework developed from previous qualitative research in patient dyads using the reusable pen. However, the IPAQ subscales did not consistently meet acceptable internal consistency reliability for some group level comparisons. Cronbach’s alphas for the total IPAQ score for both pens were 0.85, exceeding acceptable levels of reliability for group comparisons. Conclusions The total IPAQ score is a useful measure for evaluating ease of use and preference for injection pens in clinical trials among patient dyads receiving hGH. The psychometric properties of the individual subscales, mainly the lower internal consistency reliability of some of the subscales and the predictive validity findings, do not support the use of subscale scores alone as a primary endpoint.

  2. FROM DOCUMENTATION IMAGES TO RESTAURATION SUPPORT TOOLS: A PATH FOLLOWING THE NEPTUNE FOUNTAIN IN BOLOGNA DESIGN PROCESS

    Directory of Open Access Journals (Sweden)

    F. I. Apollonio

    2017-05-01

    Full Text Available The sixteenth-century Fountain of Neptune is one of Bologna’s most renowned landmarks. During the recent restoration activities of the monumental sculpture group, consisting in precious marbles and highly refined bronzes with water jets, a photographic campaign has been carried out exclusively for documentation purposes of the current state of preservation of the complex. Nevertheless, the highquality imagery was used for a different use, namely to create a 3D digital model accurate in shape and color by means of automated photogrammetric techniques and a robust customized pipeline. This 3D model was used as basic tool to support many and different activities of the restoration site. The paper describes the 3D model construction technique used and the most important applications in which it was used as support tool for restoration: (i reliable documentation of the actual state; (ii surface cleaning analysis; (iii new water system and jets; (iv new lighting design simulation; (v support for preliminary analysis and projectual studies related to hardly accessible areas; (vi structural analysis; (vii base for filling gaps or missing elements through 3D printing; (viii high-quality visualization and rendering and (ix support for data modelling and semantic-based diagrams.

  3. From Documentation Images to Restauration Support Tools: a Path Following the Neptune Fountain in Bologna Design Process

    Science.gov (United States)

    Apollonio, F. I.; Ballabeni, M.; Bertacchi, S.; Fallavollita, F.; Foschi, R.; Gaiani, M.

    2017-05-01

    The sixteenth-century Fountain of Neptune is one of Bologna's most renowned landmarks. During the recent restoration activities of the monumental sculpture group, consisting in precious marbles and highly refined bronzes with water jets, a photographic campaign has been carried out exclusively for documentation purposes of the current state of preservation of the complex. Nevertheless, the highquality imagery was used for a different use, namely to create a 3D digital model accurate in shape and color by means of automated photogrammetric techniques and a robust customized pipeline. This 3D model was used as basic tool to support many and different activities of the restoration site. The paper describes the 3D model construction technique used and the most important applications in which it was used as support tool for restoration: (i) reliable documentation of the actual state; (ii) surface cleaning analysis; (iii) new water system and jets; (iv) new lighting design simulation; (v) support for preliminary analysis and projectual studies related to hardly accessible areas; (vi) structural analysis; (vii) base for filling gaps or missing elements through 3D printing; (viii) high-quality visualization and rendering and (ix) support for data modelling and semantic-based diagrams.

  4. penORNL: a parallel Monte Carlo photon and electron transport package using PENELOPE

    Energy Technology Data Exchange (ETDEWEB)

    Bekar, Kursat B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Patton, Bruce W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Weber, Charles F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    The parallel Monte Carlo photon and electron transport code package penORNL was developed at Oak Ridge National Laboratory to enable advanced scanning electron microscope (SEM) simulations on high-performance computing systems. This paper discusses the implementations, capabilities and parallel performance of the new code package. penORNL uses PENELOPE for its physics calculations and provides all available PENELOPE features to the users, as well as some new features including source definitions specifically developed for SEM simulations, a pulse-height tally capability for detailed simulations of gamma and x-ray detectors, and a modified interaction forcing mechanism to enable accurate energy deposition calculations. The parallel performance of penORNL was extensively tested with several model problems, and very good linear parallel scaling was observed with up to 512 processors. penORNL, along with its new features, will be available for SEM simulations upon completion of the new pulse-height tally implementation.

  5. Multiplexed Dip Pen Nanolithography patterning by simple desktop nanolithography platform

    Science.gov (United States)

    Jang, Jae-Won; Smetana, Alexander; Stiles, Paul

    2010-02-01

    Multiplexed patterning in the micro-scale has been required in order to accomplish functional bio-materials templating on the subcellular length scale. Multiplexed bio-material patterns can be used in several fields: high sensitivity DNA/protein chip development, cell adhesion/differentiation studies, and biological sensor applications. Especially, two or more materials' patterning in subcellular length scale is highly demanding to develop a multi-functional and highintegrated chip device. The multiplexing patterning of two or more materials is a challenge because of difficulty in an alignment and a precision of patterning. In this work, we demonstrate that multiplexed dip pen nanolithography® (DPN®) patterning up to four different material inks by means of using recently developed new generation nanolithography platform (NLP 2000™, NanoInk, Inc., Skokie, IL). Ink materials were prepared by adding different colored fluorescent dyes to matrix carrier materials, such as poly(ethylene glycol) dimethacrylate (PEG-DMA) and lipid material (1,2- dioleoyl-sn-glycero-3-phosphocholine, DOPC). Finally, dot-array patterns of four different inks were obtained in 50 × 50 μm2 area. This lithography platform is capable of patterning 12 separate materials within micrometer areas by efficient use of the available MEMS accessories. This number can be scaled up further with development of new accessories.

  6. Squid pen chitin chitooligomers as food colorants absorbers.

    Science.gov (United States)

    Liang, Tzu-Wen; Huang, Chih-Ting; Dzung, Nguyen Anh; Wang, San-Lang

    2015-01-20

    One of the most promising applications of chitosanase is the conversion of chitinous biowaste into bioactive chitooligomers (COS). TKU033 chitosanase was induced from squid pen powder (SPP)-containing Bacillus cereus TKU033 medium and purified by ammonium sulfate precipitation and column chromatography. The enzyme was relatively more thermostable in the presence of the substrate and had an activity of 93% at 50 °C in a pH 5 buffer solution for 60 min. Furthermore, the enzyme used for the COS preparation was also studied. The enzyme products revealed various mixtures of COS that with different degrees of polymerization (DP), ranging from three to nine. In the culture medium, the fermented SPP was recovered, and it displayed a better adsorption rate (up to 96%) for the disperse dyes than the water-soluble food colorants, Allura Red AC (R40) and Tartrazne (Y4). Fourier transform-infrared spectroscopic (FT-IR) analysis proved that the adsorption of the dyes onto fermented SPP was a physical adsorption. Results also showed that fermented SPP was a favorable adsorber and could be employed as low-cost alternative for dye removal in wastewater treatment.

  7. The global diversity of sea pens (Cnidaria: Octocorallia: Pennatulacea.

    Directory of Open Access Journals (Sweden)

    Gary C Williams

    Full Text Available Recent advances in deep-sea exploration technology coupled with an increase in worldwide biotic surveys, biological research, and underwater photography in shallow water marine regions such as coral reefs, has allowed for a relatively rapid expansion of our knowledge in the global diversity of many groups of marine organisms. This paper is part of the PLoS ONE review collection of WoRMS (the Worldwide Register of Marine Species, on the global diversity of marine species, and treats the pennatulacean octocorals, a group of cnidarians commonly referred to as sea pens or sea feathers. This also includes sea pansies, some sea whips, and various vermiform taxa. Pennatulaceans are a morphologically diverse group with an estimated 200 or more valid species, displaying worldwide geographic and bathymetric distributions from polar seas to the equatorial tropics and from intertidal flats to over 6100 m in depth. The paper treats new discoveries and taxa new to science, and provides greater resolution in geographic and bathymetric distributions data than was previously known, as well as descriptions of life appearances in life and in situ observations at diverse depth.

  8. Cooling of highly charged ions in a Penning trap

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, L

    2000-03-31

    Highly charged ions are extracted from an electron beam ion trap and guided to Retrap, a cryogenic Penning trap, where they are merged with laser cooled Be{sup +} ions. The Be{sup +} ions act as a coolant for the hot highly charged ions and their temperature is dropped by about 8 orders of magnitude in a few seconds. Such cold highly charged ions form a strongly coupled nonneutral plasma exhibiting, under such conditions, the aggregation of clusters and crystals. Given the right mixture, these plasmas can be studied as analogues of high density plasmas like white dwarf interiors, and potentially can lead to the development of cold highly charged ion beams for applications in nanotechnology. Due to the virtually non existent Doppler broadening, spectroscopy on highly charged ions can be performed to an unprecedented precision. The density and the temperature of the Be{sup +} plasma were measured and highly charged ions were sympathetically cooled to similar temperatures. Molecular dynamics simulations confirmed the shape, temperature and density of the highly charged ions. Ordered structures were observed in the simulations.

  9. Robot Guided 'Pen Skill' Training in Children with Motor Difficulties.

    Science.gov (United States)

    Shire, Katy A; Hill, Liam J B; Snapp-Childs, Winona; Bingham, Geoffrey P; Kountouriotis, Georgios K; Barber, Sally; Mon-Williams, Mark

    2016-01-01

    Motor deficits are linked to a range of negative physical, social and academic consequences. Haptic robotic interventions, based on the principles of sensorimotor learning, have been shown previously to help children with motor problems learn new movements. We therefore examined whether the training benefits of a robotic system would generalise to a standardised test of 'pen-skills', assessed using objective kinematic measures [via the Clinical Kinematic Assessment Tool, CKAT]. A counterbalanced, cross-over design was used in a group of 51 children (37 male, aged 5-11 years) with manual control difficulties. Improved performance on a novel task using the robotic device could be attributed to the intervention but there was no evidence of generalisation to any of the CKAT tasks. The robotic system appears to have the potential to support motor learning, with the technology affording numerous advantages. However, the training regime may need to target particular manual skills (e.g. letter formation) in order to obtain clinically significant improvements in specific skills such as handwriting.

  10. Robot Guided 'Pen Skill' Training in Children with Motor Difficulties.

    Directory of Open Access Journals (Sweden)

    Katy A Shire

    Full Text Available Motor deficits are linked to a range of negative physical, social and academic consequences. Haptic robotic interventions, based on the principles of sensorimotor learning, have been shown previously to help children with motor problems learn new movements. We therefore examined whether the training benefits of a robotic system would generalise to a standardised test of 'pen-skills', assessed using objective kinematic measures [via the Clinical Kinematic Assessment Tool, CKAT]. A counterbalanced, cross-over design was used in a group of 51 children (37 male, aged 5-11 years with manual control difficulties. Improved performance on a novel task using the robotic device could be attributed to the intervention but there was no evidence of generalisation to any of the CKAT tasks. The robotic system appears to have the potential to support motor learning, with the technology affording numerous advantages. However, the training regime may need to target particular manual skills (e.g. letter formation in order to obtain clinically significant improvements in specific skills such as handwriting.

  11. Possible ctenophoran affinities of the Precambrian "sea-pen" Rangea.

    Science.gov (United States)

    Dzik, Jerzy

    2002-06-01

    The Namibian Kuibis Quartzite fossils of Rangea are preserved three-dimensionally owing to incomplete collapse of the soft tissues under the load of instantaneously deposited sand. The process of fossilization did not reproduce the original external morphology of the organism but rather the inner surface of collapsed organs, presumably a system of sacs connected by a medial canal. The body of Rangea had tetraradial symmetry, a body plan shared also by the White Sea Russian fossil Bomakellia and possibly some other Precambrian frond-like fossils. They all had a complex internal anatomy, smooth surface of the body, and radial membranes, making their alleged colonial nature unlikely. Despite a different style of preservation, the Middle Cambrian Burgess Shale frond-like Thaumaptilon shows several anatomical similarities to Rangea. The body plan of the Burgess Shale ctenophore Fasciculus, with its numerous, pinnately arranged comb organs, is in many respects transitional between Thaumaptilon and the Early Cambrian ctenophore Maotianoascus from the Chengjiang fauna of South China. It is proposed that the irregularly distributed dark spots on the fusiform units of the petaloid of Thaumaptilon represent a kind of macrocilia and that the units are homologous with the ctenophoran comb organs. These superficial structures were underlain by the complex serial organs, well represented in the fossils of Rangea. The Precambrian "sea-pens" were thus probably sedentary ancestors of the ctenophores.

  12. Squid Pen Chitin Chitooligomers as Food Colorants Absorbers

    Directory of Open Access Journals (Sweden)

    Tzu-Wen Liang

    2015-01-01

    Full Text Available One of the most promising applications of chitosanase is the conversion of chitinous biowaste into bioactive chitooligomers (COS. TKU033 chitosanase was induced from squid pen powder (SPP-containing Bacillus cereus TKU033 medium and purified by ammonium sulfate precipitation and column chromatography. The enzyme was relatively more thermostable in the presence of the substrate and had an activity of 93% at 50 °C in a pH 5 buffer solution for 60 min. Furthermore, the enzyme used for the COS preparation was also studied. The enzyme products revealed various mixtures of COS that with different degrees of polymerization (DP, ranging from three to nine. In the culture medium, the fermented SPP was recovered, and it displayed a better adsorption rate (up to 96% for the disperse dyes than the water-soluble food colorants, Allura Red AC (R40 and Tartrazne (Y4. Fourier transform-infrared spectroscopic (FT-IR analysis proved that the adsorption of the dyes onto fermented SPP was a physical adsorption. Results also showed that fermented SPP was a favorable adsorber and could be employed as low-cost alternative for dye removal in wastewater treatment.

  13. Interdigitated multicolored bioink micropatterns by multiplexed polymer pen lithography.

    Science.gov (United States)

    Brinkmann, Falko; Hirtz, Michael; Greiner, Alexandra M; Weschenfelder, Markus; Waterkotte, Björn; Bastmeyer, Martin; Fuchs, Harald

    2013-10-11

    Multiplexing, i.e., the application and integration of more than one ink in an interdigitated microscale pattern, is still a challenge for microcontact printing (μCP) and similar techniques. On the other hand there is a strong demand for interdigitated patterns of more than one protein on subcellular to cellular length scales in the lower micrometer range in biological experiments. Here, a new integrative approach is presented for the fabrication of bioactive microarrays and complex multi-ink patterns by polymer pen lithography (PPL). By taking advantage of the strength of microcontact printing (μCP) combined with the spatial control and capability of precise repetition of PPL in an innovative way, a new inking and writing strategy is introduced for PPL that enables true multiplexing within each repetitive subpattern. Furthermore, a specific ink/substrate platform is demonstrated that can be used to immobilize functional proteins and other bioactive compounds over a biotin-streptavidin approach. This patterning strategy aims specifically at application by cell biologists and biochemists addressing a wide range of relevant pattern sizes, easy pattern generation and adjustment, the use of only biofriendly, nontoxic chemicals, and mild processing conditions during the patterning steps. The retained bioactivity of the fabricated cm(2) area filling multiprotein patterns is demonstrated by showing the interaction of fibroblasts and neurons with multiplexed structures of fibronectin and laminin or laminin and ephrin, respectively.

  14. Aracnologias - As tecituras de Penélope

    Directory of Open Access Journals (Sweden)

    Cristina Stevens

    2009-12-01

    Full Text Available Análise da personagem Penélope, de Homero, e a transformação ousada de Joyce dessa representação clássica da fidelidade feminina em Molly Bloom, a esposa infiel, sexualizada, trivial, lírica. Essas duas personagens são comparadas com sua mais recente recriação em The Penelopiad (2005, da escritora canadense Margaret Atwood. Uma importante categoria analítica dos estudos feministas e de gênero, a questão da voz é enfatizada na presente análise; essa personagem feminina é objeto da narrativa masculina (A Odisseia e Ulisses, mas no romance de Atwood essa personagem é sujeito de sua narrativa, elaborando uma tecitura “penelopeana” transgressora da versão clássica. Focalizaremos também o poder do silêncio na narrativa de autoria feminina, através do monólogo interior de Molly e da voz que fala do mundo dos mortos em The Penelopiad. Os conceitos de “abjeto” e “linguagem semiótica” de Kristeva são base para nosso trabalho, o qual problematiza a aparente imagem de passividade dessas mulheres que buscam o controle sobre suas vidas.

  15. The early behaviour of cow and calf in an individual calving pen

    DEFF Research Database (Denmark)

    Jensen, Margit Bak

    2011-01-01

    The aim was to investigate the early behaviour in dairy cows and their calves. Thirty-eight multiparous Danish Holstein Frisian cows and their calves were housed in individual calving pens during the first twelve days post-partum and their behaviour was observed during 24 h on days 3, 7 and 11...... studied (P pens during 3 h and subsequently reintroducing them. Behavioural observations during 3 h after reintroduction showed...

  16. 中性笔绿色设计研究%Green Design Study of Gel Pen

    Institute of Scientific and Technical Information of China (English)

    贝广霞; 何盛; 刘世豪

    2015-01-01

    The problems of environmental pollution are increasingly serious with the widely use of Gel Pen,Gel Pen pollution has become a large white pollution as the same as the plastic bag . This paper analyzes the effects of various component and harm on environment of the abandoned Gel Pen, focusing on the structure of Gel pen , the research proposed a green design method . Through the redesign for the structure of Gel Pen , it is convenient to fill ink into the pen and to replace the damaged pen tip ,which can extend the life of Gel Pen , reduce the waste of resources and environmental pollution, and realize the purpose of environmental protection.%随着中性笔的推广,由此带来的环境污染问题也日益严重,“中性笔污染”已经成为继塑料袋之后的又一大白色污染。在分析废弃中性笔各零部件对环境所带来的影响及危害的基础上,从中性笔本身的设计结构出发,提出了中性笔的绿色设计方案。通过对中性笔芯结构的改进,使笔杆和笔头的连接为密封螺纹连接,大大延长了中性笔芯的使用寿命,达到节能减排,保护环境的目的。

  17. Pen size and parity effects on maternal behaviour of Small-Tail Han sheep.

    Science.gov (United States)

    Lv, S-J; Yang, Y; Dwyer, C M; Li, F-K

    2015-07-01

    The aim of this experiment was to study the effects of pen size and parity on maternal behaviour of twin-bearing Small-Tail Han ewes. A total of 24 ewes were allocated to a 2×2 design (six per pen), with parity (primiparous or multiparous) and pen size (large: 6.0×3.0 m; small: 6.0×1.5 m) as main effects at Linyi University, Shandong Province, China. Behaviour was observed from after parturition until weaning. All ewes were observed for 6 h every 5 days from 0700 to1000 h and from 1400 to 1700 h. Continuous focal animal sampling was used to quantify the duration of maternal behaviours: sucking, grooming and following as well as the frequency of udder accepting, udder refusing and low-pitched bleating. Oestradiol and cortisol concentrations in the faeces (collected in the morning every 5 days) were detected using EIA kits. All lambs were weighed 24 h after parturition and again at weaning at 35 days of age. The small pen size significantly reduced following (Pprimiparous ewes (Pprimiparous ewes (P<0.001), and ewes in small pens had higher faecal cortisol levels compared with ewes in larger pens (P<0.001). As lambs increased in age, the duration of maternal grooming, following and suckling as well as frequency of udder acceptance and low-pitched bleating all declined, and the frequency of udder refusing increased (P<0.001 for all). Ewe parity, but not pen size, affected lamb weight gain during the period of observation (P<0.001). This is the first study to show that pen size, interacting with parity, can affect the expression of maternal behaviour in sheep during lactation. The study is also the first to report on the maternal behaviour of Chinese native sheep breeds (Small-Tail Han sheep), with implications for the production of sheep in China.

  18. Verifying the accuracy of the TITAN Penning-trap mass spectrometer

    CERN Document Server

    Brodeur, M; Brunner, T; Ettenauer, S; Gallant, A T; Simon, V V; Smith, M J; Lapierre, A; Ringle, R; Delheij, P; Good, M; Lunney, D; Dilling, J

    2011-01-01

    TITAN (TRIUMF's Ion Traps for Atomic and Nuclear science) is an online facility designed to carry out high-precision mass measurements on singly and highly charged radioactive ions. The TITAN Penning trap has been built and optimized in order to perform such measurements with an accuracy in the sub ppb-range. A detailed characterization of the TITAN Penning trap is presented and a new compensation method is derived and demonstrated, verifying the performance in the range of sub-ppb.

  19. Processing and Analyzing Assessment Test Logs provided by Digital Pen and Paper

    OpenAIRE

    Barhoumi, Zaara; Tort, Françoise

    2011-01-01

    In an educational context, the use of new technologies can influence and change teaching practices. Digital pen and paper, as man-machine interface, appears familiar and do not require any specific training. Analyzing logs recorded by this technology, especially time, seems interesting in order to provide new indicators for evaluation or observation. As far as we know, time stamped logs recorded by digital pen is barely studied in an educational context by researchers. We explore the use of d...

  20. Update on insulin treatment for dogs and cats: insulin dosing pens and more

    Directory of Open Access Journals (Sweden)

    Thompson A

    2015-04-01

    Full Text Available Ann Thompson,1 Patty Lathan,2 Linda Fleeman3 1School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia; 2College of Veterinary Medicine Mississippi State University, Starkville, MS, USA; 3Animal Diabetes Australia, Melbourne, VIC, Australia Abstract: Insulin therapy is still the primary therapy for all diabetic dogs and cats. Several insulin options are available for each species, including veterinary registered products and human insulin preparations. The insulin chosen depends on the individual patient's requirements. Intermediate-acting insulin is usually the first choice for dogs, and longer-acting insulin is the first choice for cats. Once the insulin type is chosen, the best method of insulin administration should be considered. Traditionally, insulin vials and syringes have been used, but insulin pen devices have recently entered the veterinary market. Pens have different handling requirements when compared with standard insulin vials including: storage out of the refrigerator for some insulin preparations once pen cartridges are in use; priming of the pen to ensure a full dose of insulin is administered; and holding the pen device in place for several seconds during the injection. Many different types of pen devices are available, with features such as half-unit dosing, large dials for visually impaired people, and memory that can display the last time and dose of insulin administered. Insulin pens come in both reusable and disposable options. Pens have several benefits over syringes, including improved dose accuracy, especially for low insulin doses. Keywords: diabetes, mellitus, canine, feline, NPH, glargine, porcine lente

  1. RESEARCHES REGARDING THE MAIN REPRODUCTION INDICATORS DETERMINATED IN SOWS, STAND GESTATION PEN TIPE

    Directory of Open Access Journals (Sweden)

    TELEA ADA

    2007-01-01

    Full Text Available Current researches were carried out with the goal to quantisize the lost from the weaning to early gestation at the sows housed in open pen gestation. In this trail wetested two pen types, different not only by size, but also by feeders’ emplacement.The main reproduction indicators that we calculated until the 28 gestation day werethe proportion of sows in heat after weaning, the weaning to estrus interval and thegestation rates. The weaning to estrus interval was about 4 to 7 days, most sowswere in heat in the day 5 and 6 days after weaning. The percent of heat detectionafter weaning was 71.42% for the small pens and 70.71% for the big pens(differences statistically non significant, chi test value was 0.983. The gestation rateat 28 days after insemination was 91.62% for the small pens and 94.72% for thelarge pens (chi test value 0,959, statistically non significant differences. Theoverpopulation for heat induction and after that chipping animals together in thosepens, show that the lost are up to 40.47%, between weaning – day 28 of gestation.

  2. Breakdown Voltage Research of Penning Gas Mixture in Plasma Display Panel

    Institute of Scientific and Technical Information of China (English)

    Guo Bingang; Liu Chunliang; Song Zhongxiao; Fan Yufeng; Xia Xing; Liu Liu; Fan Duowang

    2005-01-01

    Paschen law and equations, which ignore the influence of the Penning ionization on the electron ionization coefficient (α), are always used as the approximation of the breakdown voltage criterion of the Penning gas mixture in current researches of discharge characteristics of the plasma display panel (PDP). It is doubtful that whether their results match the facts. Based on the Townsend gas self-sustaining discharge condition and the chemical kinetics analysis of the Penning gas mixture discharging in PDP, the empirical equation to describe the breakdown of the Penning gas mixture is given. It is used to calculate the breakdown voltage curves of Ne-Xe/MgO and Ne-Ar/MgO in a testing macroscopic discharge cell of AC-PDP. The effective secondary electron emission coefficients (γeff) of the MgO protective layers are derived by comparing the breakdown voltage curves obtained from the empirical equation with the experimental data of breakdown voltages. In comparison with the results calculated by the Paschen law and the equation which ignore the influence of the Penning ionization on α , the results calculated by the empirical equation have better conformity with experimental data. The empirical equation characterizes the breakdown of the Penning gas mixture in PDP effectively, and gives a convenient way to study its breakdown characteristics and the secondary electron emission behaviors.

  3. Usage and perceptions of pen injectors for diabetes management: a survey of type 2 diabetes patients in the United States.

    Science.gov (United States)

    Toscano, Deborah; Brice, Jennifer; Alfaro, Christina

    2012-05-01

    This study was conducted to investigate type 2 diabetes mellitus (T2DM) patient perceptions of their pen injectors and determine which features were deemed most important to overall satisfaction. Frost & Sullivan conducted a Web-based survey of T2DM patients in the United States in November 2010. Survey participants were initially screened prior to full participation. A total of 1002 adult T2DM patients who were using a pen injector on a regular basis to administer their diabetes medication(s) were surveyed. The survey consisted of 24 questions focused on awareness and current usage of pen injectors by type and brand, specific features of pen injectors, and patients' preferences for and satisfaction with pen injectors. The majority of surveyed patients were using prefilled pen injectors as compared with durable pens. The LANTUS SoloSTAR (sanofi-aventis) was reported to be the most commonly used pen. The LANTUS SoloSTAR was also ranked highly for overall satisfaction and likelihood of continued usage. Regardless of brand, most surveyed patients reported that they were likely to continue using their current pen. In general, the single most important feature for user satisfaction was an easy push-button injection. Ease of self-administration is of highest priority to users of pen injectors. Important features facilitating ease of use, such as an easily depressed push-button injection, are likely to minimize the burden on T2DM patients, thereby improving compliance and clinical outcomes. © 2012 Diabetes Technology Society.

  4. Microfabrication of diamond-based slow-wave circuits for mm-wave and THz vacuum electronic sources

    Science.gov (United States)

    Lueck, M. R.; Malta, D. M.; Gilchrist, K. H.; Kory, C. L.; Mearini, G. T.; Dayton, J. A.

    2011-06-01

    Planar and helical slow-wave circuits for THz radiation sources have been made using novel microfabrication and assembly methods. A biplanar slow-wave circuit for a 650 GHz backward wave oscillator (BWO) was fabricated through the growth of diamond into high aspect ratio silicon molds and the selective metallization of the tops and sidewalls of 90 µm tall diamond features using lithographically created shadow masks. Helical slow-wave circuits for a 650 GHz BWO and a 95 GHz traveling wave tube were created through the patterning of trenches in thin film diamond, electroplating of gold half-helices, and high accuracy bonding of helix halves. The development of new techniques for the microfabrication of vacuum electronic components will help to facilitate compact and high-power sources for terahertz range radiation.

  5. Microfabrication of a Segmented-Involute-Foil Regenerator, Testing in a Sunpower Stirling Convertor and Supporting Modeling and Analysis

    Science.gov (United States)

    Ibrahim, Mounir B.; Tew, Roy C.; Gedeon, David; Wood, Gary; McLean, Jeff

    2008-01-01

    Under Phase II of a NASA Research Award contract, a prototype nickel segmented-involute-foil regenerator was microfabricated via LiGA and tested in the NASA/Sunpower oscillating-flow test rig. The resulting figure-of-merit was about twice that of the approx.90% porosity random-fiber material currently used in the small 50-100 W Stirling engines recently manufactured for NASA. That work was reported at the 2007 International Energy Conversion Engineering Conference in St. Louis, was also published as a NASA report, NASA/TM-2007-2149731, and has been more completely described in a recent NASA Contractor Report, NASA/CR-2007-2150062. Under a scaled-back version of the original Phase III plan, a new nickel segmentedinvolute- foil regenerator was microfabricated and has been tested in a Sunpower Frequency-Test-Bed (FTB) Stirling convertor. Testing in the FTB convertor produced about the same efficiency as testing with the original random-fiber regenerator. But the high thermal conductivity of the prototype nickel regenerator was responsible for a significant performance degradation. An efficiency improvement (by a 1.04 factor, according to computer predictions) could have been achieved if the regenerator been made from a low-conductivity material. Also the FTB convertor was not reoptimized to take full advantage of the microfabricated regenerator's low flow resistance; thus the efficiency would likely have been even higher had the FTB been completely reoptimized. This report discusses the regenerator microfabrication process, testing of the regenerator in the Stirling FTB convertor, and the supporting analysis. Results of the pre-test computational fluid dynamics (CFD) modeling of the effects of the regenerator-test-configuration diffusers (located at each end of the regenerator) is included. The report also includes recommendations for accomplishing further development of involute-foil regenerators from a higher-temperature material than nickel.

  6. Micro-fabrication considerations for MEMS-based reconfigurable antenna apertures: with emphasis on DC bias network

    Science.gov (United States)

    Moghadas, Hamid; Mousavi, Pedram; Daneshmand, Mojgan

    2016-11-01

    This note addresses the main challenges involved in monolithic micro-fabrication of large capacitive-MEMS-based reconfigurable electromagnetic apertures in antenna applications. The fabrication of a large DC bias line network, and also the metallic features in such apertures, requires special attention and optimization. It is shown that the choice of DC bias network material can impact DC and RF performance of the structure, and a trade-off between switching time and radiation pattern integrity should be considered.

  7. Microfabrication of chip-sized scaffolds for three-dimensional cell cultivation.

    Science.gov (United States)

    Giselbrecht, Stefan; Gottwald, Eric; Truckenmueller, Roman; Trautmann, Christina; Welle, Alexander; Guber, Andreas; Saile, Volker; Gietzelt, Thomas; Weibezahn, Karl-Friedrich

    2008-05-12

    Using microfabrication technologies is a prerequisite to create scaffolds of reproducible geometry and constant quality for three-dimensional cell cultivation. These technologies offer a wide spectrum of advantages not only for manufacturing but also for different applications. The size and shape of formed cell clusters can be influenced by the exact and reproducible architecture of the microfabricated scaffold and, therefore, the diffusion path length of nutrients and gases can be controlled.1 This is unquestionably a useful tool to prevent apoptosis and necrosis of cells due to an insufficient nutrient and gas supply or removal of cellular metabolites. Our polymer chip, called CellChip, has the outer dimensions of 2 x 2 cm with a central microstructured area. This area is subdivided into an array of up to 1156 microcontainers with a typical dimension of 300 m edge length for the cubic design (cp- or cf-chip) or of 300 m diameter and depth for the round design (r-chip).2 So far, hot embossing or micro injection moulding (in combination with subsequent laborious machining of the parts) was used for the fabrication of the microstructured chips. Basically, micro injection moulding is one of the only polymer based replication techniques that, up to now, is capable for mass production of polymer microstructures.3 However, both techniques have certain unwanted limitations due to the processing of a viscous polymer melt with the generation of very thin walls or integrated through holes. In case of the CellChip, thin bottom layers are necessary to perforate the polymer and provide small pores of defined size to supply cells with culture medium e.g. by microfluidic perfusion of the containers. In order to overcome these limitations and to reduce the manufacturing costs we have developed a new microtechnical approach on the basis of a down-scaled thermoforming process. For the manufacturing of highly porous and thin walled polymer chips, we use a combination of heavy ion

  8. THE ORIGIN OF THE HOT GAS IN THE GALACTIC HALO: TESTING GALACTIC FOUNTAIN MODELS' X-RAY EMISSION

    Energy Technology Data Exchange (ETDEWEB)

    Henley, David B.; Shelton, Robin L. [Department of Physics and Astronomy, University of Georgia, Athens, GA 30602 (United States); Kwak, Kyujin [School of Natural Science, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulju-gun, Ulsan 689-798 (Korea, Republic of); Hill, Alex S. [CSIRO Astronomy and Space Science, Marsfield, NSW (Australia); Mac Low, Mordecai-Mark, E-mail: dbh@physast.uga.edu [Department of Astrophysics, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024 (United States)

    2015-02-20

    We test the X-ray emission predictions of galactic fountain models against XMM-Newton measurements of the emission from the Milky Way's hot halo. These measurements are from 110 sight lines, spanning the full range of Galactic longitudes. We find that a magnetohydrodynamical simulation of a supernova-driven interstellar medium, which features a flow of hot gas from the disk to the halo, reproduces the temperature but significantly underpredicts the 0.5-2.0 keV surface brightness of the halo (by two orders of magnitude, if we compare the median predicted and observed values). This is true for versions of the model with and without an interstellar magnetic field. We consider different reasons for the discrepancy between the model predictions and the observations. We find that taking into account overionization in cooled halo plasma, which could in principle boost the predicted X-ray emission, is unlikely in practice to bring the predictions in line with the observations. We also find that including thermal conduction, which would tend to increase the surface brightnesses of interfaces between hot and cold gas, would not overcome the surface brightness shortfall. However, charge exchange emission from such interfaces, not included in the current model, may be significant. The faintness of the model may also be due to the lack of cosmic ray driving, meaning that the model may underestimate the amount of material transported from the disk to the halo. In addition, an extended hot halo of accreted material may be important, by supplying hot electrons that could boost the emission of the material driven out from the disk. Additional model predictions are needed to test the relative importance of these processes in explaining the observed halo emission.

  9. A Multi-Sensor Approach for Volcanic Ash Cloud Retrieval and Eruption Characterization: The 23 November 2013 Etna Lava Fountain

    Directory of Open Access Journals (Sweden)

    Stefano Corradini

    2016-01-01

    Full Text Available Volcanic activity is observed worldwide with a variety of ground and space-based remote sensing instruments, each with advantages and drawbacks. No single system can give a comprehensive description of eruptive activity, and so, a multi-sensor approach is required. This work integrates infrared and microwave volcanic ash retrievals obtained from the geostationary Meteosat Second Generation (MSG-Spinning Enhanced Visible and Infrared Imager (SEVIRI, the polar-orbiting Aqua-MODIS and ground-based weather radar. The expected outcomes are improvements in satellite volcanic ash cloud retrieval (altitude, mass, aerosol optical depth and effective radius, the generation of new satellite products (ash concentration and particle number density in the thermal infrared and better characterization of volcanic eruptions (plume altitude, total ash mass erupted and particle number density from thermal infrared to microwave. This approach is the core of the multi-platform volcanic ash cloud estimation procedure being developed within the European FP7-APhoRISM project. The Mt. Etna (Sicily, Italy volcano lava fountaining event of 23 November 2013 was considered as a test case. The results of the integration show the presence of two volcanic cloud layers at different altitudes. The improvement of the volcanic ash cloud altitude leads to a mean difference between the SEVIRI ash mass estimations, before and after the integration, of about the 30%. Moreover, the percentage of the airborne “fine” ash retrieved from the satellite is estimated to be about 1%–2% of the total ash emitted during the eruption. Finally, all of the estimated parameters (volcanic ash cloud altitude, thickness and total mass were also validated with ground-based visible camera measurements, HYSPLIT forward trajectories, Infrared Atmospheric Sounding Interferometer (IASI satellite data and tephra deposits.

  10. [Preference for etanercept pen versus syringe in patients with chronic arthritis. Nurse education workshop].

    Science.gov (United States)

    Garcia-Diaz, Silvia; Girabent-Farrés, Montserrat; Roig-Vilaseca, Daniel; Reina, Delia; Cerdà, Dacia; González, Marina; Torrente-Segarra, Vicenç; Fíguls, Ramon; Corominas, Hèctor

    2013-01-01

    The aims of this study are to evaluate the level of fear of post-injection pain prior to the administration, the difficulty in handling the device, and the level of satisfaction of patients using a pre-filled syringe versus an etanercept pen, as well as to evaluate the usefulness of the training given by nursing staff prior to starting with the pen, and the preferences of patients after using both devices. A prospective study was designed to follow-up a cohort of patients during a 6 months period. The data was collected using questionnaires and analyzed with SPSS 18.00. Rank and McNemar tests were performed. Statistical significance was pre-set at an α level of 0.05. A total of 29 patients were included, of whom 69% female, and with a mean age 52.5±10.9 years. Of these, 48% had rheumatoid arthritis, 28% psoriatic arthritis, 21% ankylosing spondylitis, and 3% undifferentiated spondyloarthropathy. There were no statistically significant differences either with the fear or pain or handling of the device between the syringe and the pen (P=.469; P=.812; P=.169 respectively). At 6 months, 59% of patients referred to being satisfied or very satisfied with the pen. Almost all (93%) found useful or very useful the training given by nursing staff prior to using the pen, and 55% preferred the pen over the pre-filled syringe. The etanercept pen is another subcutaneous device option for patients with chronic arthritis. According to the present study, nursing educational workshops before starting this therapy are recommended. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  11. Improved frequency measurement of the $^1S_{0}$-$^3P_{0}$ clock transition in $^{87}$Sr using the Cs fountain clock at NMIJ as a transfer oscillator

    CERN Document Server

    Tanabe, Takehiko; Kobayashi, Takumi; Takamizawa, Akifumi; Yanagimachi, Shinya; Ikegami, Takeshi; Suzuyama, Tomonari; Inaba, Hajime; Okubo, Sho; Yasuda, Masami; Hong, Feng-Lei; Onae, Atsushi; Hosaka, Kazumoto

    2015-01-01

    We performed an absolute frequency measurement of the $^1S_{0}$-$^3P_{0}$ transition in $^{87}$Sr with a fractional uncertainty of $1.2 \\times 10^{-15}$, which is less than one third that of our previous measurement. A caesium fountain atomic clock was used as a transfer oscillator to reduce the uncertainty of the link between a strontium optical lattice clock and the SI second. The absolute value of the transition frequency is 429 228 004 229 873.56(49) Hz.

  12. A novel pen-based Bluetooth-enabled insulin delivery system with insulin dose tracking and advice.

    Science.gov (United States)

    Bailey, Timothy S; Stone, Jenine Y

    2017-05-01

    Diabetes is growing in prevalence internationally. As more individuals require insulin as part of their treatment, technology evolves to optimize delivery, improve adherence, and reduce dosing errors. Insulin pens outperform vial and syringe in simplicity, dosing accuracy, and user preference. Bolus advisors improve dosing confidence and treatment adherence. The InPen System offers a novel approach to treatment via a wireless pen that syncs to a mobile application featuring a bolus advisor, enabling convenient insulin dose tracking and more accurate bolus advice among other features. Areas covered: Existing technology for insulin delivery and bolus advice are reviewed. The mechanics and functionality of the InPen device are delineated. Findings from formative testing and usability studies of the InPen system are reported. Future directions for the InPen system in the treatment of diabetes are discussed. Expert opinion: Diabetes management is complex and largely data-driven. The InPen System offers a promising new opportunity to avail insulin pen-users of features known to improve treatment efficacy, which have otherwise primarily been available to those using pumps. Given that the majority of insulin users do not use insulin pumps, the InPen System is poised to improve glucose control in a significant portion of the diabetes population.

  13. Microfabricated Thin-Film Inductors for High-Frequency DC-DC Power Conversion

    Science.gov (United States)

    Yao, Di

    2011-12-01

    Microfabricated V-groove inductors targeted to operate above 10 MHz are investigated. Multilayer nano-granular Co-Zr-O/ZrO2 magnetic thin films are used as the core material of the inductors to improve the magnetic performance of the films deposited on the sidewalls of V-grooves and to control eddy-current loss in the core, which goes up very quickly as frequency increases. A loss model is developed to estimate eddy-current loss in multilayer magnetic thin films considering the effect of displacement current at high frequencies, and the model is applied in the design of V-groove inductors. V-groove inductors using multilayer magnetic thin films are co-optimized with power MOSFETs for 7-V to 3.3-V, 1-A DC-DC buck converters to maximize power handling capability per unit substrate area for given efficiencies. Prototype V-groove inductors are fabricated based on the optimization results, and measured and predicted performance of the inductors match well. The prototype inductors are a promising candidate for high-power-density high-efficiency DC-DC converters. The 7-V to 3.3-V, 1-A converters using prototype V-groove inductors are expected to exhibit power density of 2.5 W/mm2 and efficiency of 86% at 100 MHz, and power density of 0.36 W/mm2 and efficiency of 91% at 11 MHz.

  14. Comprehensive two-dimensional gas chromatographic separations with a temperature programmed microfabricated thermal modulator.

    Science.gov (United States)

    Collin, William R; Nuñovero, Nicolas; Paul, Dibyadeep; Kurabayashi, Katsuo; Zellers, Edward T

    2016-04-29

    Comprehensive two-dimensional gas chromatography (GC×GC) with a temperature-programmed microfabricated thermal modulator (μTM) is demonstrated. The 0.78 cm(2), 2-stage μTM chip with integrated heaters and a PDMS coated microchannel was placed in thermal contact with a solid-state thermoelectric cooler and mounted on top of a bench scale GC. It was fluidically coupled through heated interconnects to an upstream first-dimension ((1)D) PDMS-coated capillary column and a downstream uncoated capillary or second-dimension ((2)D) PEG-coated capillary. A mixture of n-alkanes C6-C10 was separated isothermally and the full-width-at-half-maximum (fwhm) values of the modulated peaks were assessed as a function of the computer-controlled minimum and maximum stage temperatures of μTM, Tmin and Tmax, respectively. With Tmin and Tmax fixed at -25 and 100°C, respectively, modulated peaks of C6 and C7 had fwhm valuesthermal modulator. Replacing the PDMS phase in the μTM with a trigonal-tricationic room temperature ionic liquid eliminated the bleed observed with the PDMS, but also reduced the capacity for several test compounds. Regardless, the demonstrated capability to independently temperature program this low resource μTM enhances its versatility and its promise for use in bench-scale GC×GC systems.

  15. Micro-fabricated Silicon Devices for Advanced Thermal Management and Integration of Particle Tracking Detectors

    CERN Document Server

    Romagnoli, Giulia; Gambaro, Carla

    Since their first studies targeting the cooling of high-power computing chips, micro-channel devices are proven to provide a very efficient cooling system. In the last years micro-channel cooling has been successfully applied to the cooling of particle detectors at CERN. Thanks to their high thermal efficiency, they can guarantee a good heat sink for the cooling of silicon trackers, fundamental for the reduction of the radiation damage caused by the beam interactions. The radiation damage on the silicon detector is increasing with temperature and furthermore the detectors are producing heat that should be dissipated in the supporting structure. Micro-channels guarantee a distributed and uniform thermal exchange, thanks to the high flexibility of the micro-fabrication process that allows a large variety of channel designs. The thin nature of the micro-channels etched inside silicon wafers, is fulfilling the physics requirement of minimization of the material crossed by the particle beam. Furthermore micro-chan...

  16. Thermo-mechanical properties and microfabric of fly ash-stabilized gold tailings.

    Science.gov (United States)

    Lee, Joon Kyu; Shang, Julie Q; Jeong, Sangseom

    2014-07-15

    This paper studies the changes in thermal conductivity, temperature, and unconfined compressive strength of gold tailings and fly ash mixtures during the curing period of 5 days. The microfabric of the cured mixtures was investigated with mercury intrusion porosimetry (MIP). The mixture samples were prepared at their maximum dry unit weight and optimum moisture content. Effect of adding fly ash to gold tailings (i.e., 0, 20, and 40% of the dry weight of tailings) was examined, and a comparison was made on samples prepared at the same fly ash content by replacing gold tailings with humic acid (i.e., gold tailings and humic acid ratios of 100:0, 90:10, and 80:20 by weight) or by varying pore fluid chemistry (i.e., water and salt solutions of 1M NaCl and CaCl2). The results show that the initial thermal conductivity of the samples is sensitive to the mixture proportion and a declination in the thermal conductivity is observed due to hydration of fly ash and evaporation. Inclusion of fly ash and salts into gold tailings improves the unconfined compressive strength but the presence of humic acid in samples leads to the decrease of the strength. MIP results reveal the pore structure changes associated with the packing states of the samples that reflect the influential factors considered. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Technology for On-Chip Qubit Control with Microfabricated Surface Ion Traps

    Energy Technology Data Exchange (ETDEWEB)

    Highstrete, Clark [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Quantum Information Sciences Dept.; Scott, Sean Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). RF/Optoelectronics Dept.; Nordquist, Christopher D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). RF/Optoelectronics Dept.; Sterk, Jonathan David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photonic Microsystem Technologies Dept.; Maunz, Peter Lukas Wilhelm [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photonic Microsystem Technologies Dept.; Tigges, Christopher P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photonic Microsystem Technologies Dept.; Blain, Matthew Glenn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photonic Microsystem Technologies Dept.; Heller, Edwin J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Microsystems Integration Dept.; Stevens, James E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). MESAFab Operations 2 Dept.

    2013-11-01

    Trapped atomic ions are a leading physical system for quantum information processing. However, scalability and operational fidelity remain limiting technical issues often associated with optical qubit control. One promising approach is to develop on-chip microwave electronic control of ion qubits based on the atomic hyperfine interaction. This project developed expertise and capabilities at Sandia toward on-chip electronic qubit control in a scalable architecture. The project developed a foundation of laboratory capabilities, including trapping the 171Yb+ hyperfine ion qubit and developing an experimental microwave coherent control capability. Additionally, the project investigated the integration of microwave device elements with surface ion traps utilizing Sandia’s state-of-the-art MEMS microfabrication processing. This effort culminated in a device design for a multi-purpose ion trap experimental platform for investigating on-chip microwave qubit control, laying the groundwork for further funded R&D to develop on-chip microwave qubit control in an architecture that is suitable to engineering development.

  18. Microfabrication and Integration of a Sol-Gel PZT Folded Spring Energy Harvester

    Directory of Open Access Journals (Sweden)

    Jonathan Lueke

    2015-05-01

    Full Text Available This paper presents the methodology and challenges experienced in the microfabrication, packaging, and integration of a fixed-fixed folded spring piezoelectric energy harvester. A variety of challenges were overcome in the fabrication of the energy harvesters, such as the diagnosis and rectification of sol-gel PZT film quality and adhesion issues. A packaging and integration methodology was developed to allow for the characterizing the harvesters under a base vibration. The conditioning circuitry developed allowed for a complete energy harvesting system, consisting a harvester, a voltage doubler, a voltage regulator and a NiMH battery. A feasibility study was undertaken with the designed conditioning circuitry to determine the effect of the input parameters on the overall performance of the circuit. It was found that the maximum efficiency does not correlate to the maximum charging current supplied to the battery. The efficiency and charging current must be balanced to achieve a high output and a reasonable output current. The development of the complete energy harvesting system allows for the direct integration of the energy harvesting technology into existing power management schemes for wireless sensing.

  19. Microfabricated engineered particle systems for respiratory drug delivery and other pharmaceutical applications.

    Science.gov (United States)

    Garcia, Andres; Mack, Peter; Williams, Stuart; Fromen, Catherine; Shen, Tammy; Tully, Janet; Pillai, Jonathan; Kuehl, Philip; Napier, Mary; Desimone, Joseph M; Maynor, Benjamin W

    2012-01-01

    Particle Replication in Non-Wetting Templates (PRINT(®)) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.

  20. Heat transfer simulation and thermal measurements of microfabricated x-ray transparent heater stages.

    Science.gov (United States)

    Baldasseroni, C; Queen, D R; Cooke, David W; Maize, K; Shakouri, A; Hellman, F

    2011-09-01

    A microfabricated amorphous silicon nitride membrane-based nanocalorimeter is proposed to be suitable for an x-ray transparent sample platform with low power heating and built-in temperature sensing. In this work, thermal characterization in both air and vacuum are analyzed experimentally and via simulation. Infrared microscopy and thermoreflectance microscopy are used for thermal imaging of the sample area in air. While a reasonably large isothermal area is found on the sample area, the temperature homogeneity of the entire sample area is low, limiting use of the device as a heater stage in air or other gases. A simulation model that includes conduction, as well as radiation and convection heat loss, is presented with radiation and convection parameters determined experimentally. Simulated temperature distributions show that the homogeneity can be improved by using a thicker thermal conduction layer or reducing the pressure of the gas in the environment but neither are good solutions for the proposed use. A new simple design that has improved temperature homogeneity and a larger isothermal area while maintaining a thin thermal conduction layer is proposed and fabricated. This new design enables applications in transmission x-ray microscopes and spectroscopy setups at atmospheric pressure. © 2011 American Institute of Physics

  1. Complex fluids under microflow probed by SAXS: rapid microfabrication and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Hazel P; Luckham, Paul F; Cabral, Joao T [Department of Chemical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Brooks, Nicholas J; Seddon, John M [Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Terrill, Nick J [Diamond Light Source Ltd., Diamond House, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire, OX11 0DE (United Kingdom); Kowalski, Adam J, E-mail: j.cabral@imperial.ac.u [Unilever Research and Development, Port Sunlight Laboratory, Bebington, Wirral, CH63 3JW (United Kingdom)

    2010-10-01

    We report a combined microfluidic and online synchrotron small-angle X-ray scattering (SAXS) study of complex surfactant mixtures under flow. We investigate the influence of a series of flow constrictions, generating well-defined, periodic extensional flow fields, on the microstructure of two model surfactant mixtures containing SDS and CTAC. Specifically, the lamella spacing, orientation and structural order are reported and correlated with the imposed flow field: geometry, flow velocity and residence time. The design, fabrication and operation of a microfluidic system using rapid prototyping is described in detail. We show that polydimethyl siloxane (PDMS), ubiquitous in microfabrication, provides a suitable matrix for SAXS microdevices provided that: (i) PDMS thickness are kept to a minimum while retaining structural integrity ({approx}1000{mu}m) and (ii) scattering from the structure of interest is sufficiently decoupled from the amorphous background scattering. The combination SAXS-microfluidics provides unprecedented opportunities to elucidate the non-equilibrium structure formation and relaxation of complex fluids, demonstrated here for concentrated surfactant mixtures.

  2. A review of microfabrication techniques and dielectrophoretic microdevices for particle manipulation and separation

    Science.gov (United States)

    Li, M.; Li, W. H.; Zhang, J.; Alici, G.; Wen, W.

    2014-02-01

    The development of lab-on-a-chip (LOC) devices over the past decade has attracted growing interest. LOC devices aim to achieve the miniaturization, integration, automation and parallelization of biological and chemical assays. One of the applications, the ability to effectively and accurately manipulate and separate micro- and nano-scale particles in an aqueous solution, is particularly appealing in biological, chemical and medical fields. Among the technologies that have been developed and implemented in microfluidic microsystems for particle manipulation and separation (such as mechanical, inertial, hydrodynamic, acoustic, optical, magnetic and electrical methodologies), dielectrophoresis (DEP) may prove to be the most popular because of its label-free nature, ability to manipulate neutral bioparticles, analyse with high selectivity and sensitivity, compatibility with LOC devices, and easy and direct interface with electronics. The required spatial electric non-uniformities for the DEP effect can be generated by patterning microelectrode arrays within microchannels, or placing insulating obstacles within a microchannel and curving the microchannels. A wide variety of electrode- and insulator-based DEP microdevices have been developed, fabricated, and successfully employed to manipulate and separate bioparticles (i.e. DNA, proteins, bacteria, viruses, mammalian and yeast cells). This review provides an overview of the state-of-the-art of microfabrication techniques and of the structures of dielectrophoretic microdevices aimed towards different applications. The techniques used for particle manipulation and separation based on microfluidics are provided in this paper. In addition, we also present the theoretical background of DEP.

  3. Microfabricated devices for cell biology: all for one and one for all.

    Science.gov (United States)

    Lautenschläger, Franziska; Piel, Matthieu

    2013-02-01

    Individual cells in their native physiological states face a dynamic multi-factorial environment. This is true of both single-celled and multi-cellular organisms. A key challenge in cell biology is the design of experimental methods and specific assays to disentangle the contribution of each of the parameters governing cell behavior. After decades of studying cells cultured in Petri dishes or on glass coverslips, researchers can now benefit from a range of recent technological developments that allow them to study cells in a variety of contexts, with different levels of complexity and control over a range of environmental parameters. These technologies include new types of microscopy for detailed imaging of large cell aggregates or even whole tissues, and the development of cell culture substrates, such as 3D matrices. Here we will review the contribution of a third type of tool, collectively known as microfabricated tools. Derived from techniques originally developed for microelectronics, these tools range in size from hundreds of microns to hundreds of nanometers.

  4. Microfabrication and Characterization of an Integrated 3-Axis CMOS-MEMS Accelerometer

    Directory of Open Access Journals (Sweden)

    Hongwei QU

    2007-10-01

    Full Text Available This paper reports the fabrication and characterization of a monolithically integrated 3-axis CMOS-MEMS accelerometer with a single proof mass. An improved microfabrication process has been developed to solve the structure overheating and particle contamination problems in the plasma etching processes of device fabrication. The whole device is made of bulk silicon except for some short thin films for electrical isolation, allowing large sensing capacitance and flat device structure. A low-noise, low-power amplifier is designed for each axis, which provides 40 dB on-chip amplification and consumes only 1 mW power. Quasi-static and dynamic characterization of the fabricated device has been performed. The measured sensitivities of the lateral- and z-axis accelerometers are 560 mV/g and 320 mV/g, respectively, which can be tuned by simply varying the amplitude of the modulation signal. The over-all noise floors of the lateral- and z-axis are 12 μg/ÖHz and 110 μg/ÖHz, respectively when tested at 200 Hz.

  5. A microfabricated magnetic force transducer-microaspiration system for studying membrane mechanics

    Science.gov (United States)

    Stark, D. J.; Killian, T. C.; Raphael, R. M.

    2011-10-01

    The application of forces to cell membranes is a powerful method for studying membrane mechanics. To apply controlled dynamic forces on the piconewton scale, we designed and characterized a microfabricated magnetic force transducer (MMFT) consisting of current-carrying gold wires patterned on a sapphire substrate. The experimentally measured forces applied to paramagnetic and ferromagnetic beads as a function of applied current agree well with theoretical models. We used this device to pull tethers from microaspirated giant unilamellar vesicles and measure the threshold force for tether formation. In addition, the interlayer drag coefficient of the membrane was determined from the tether-return velocity under magnetic force-free conditions. At high levels of current, vesicles expanded as a result of local temperature changes. A finite element thermal model of the MMFT provided absolute temperature calibration, allowing determination of the thermal expansivity coefficient of stearoyl-oleoyl-phosphatidycholine vesicles (1.7 ± 0.4 × 10-3 K-1) and characterization of the Joule heating associated with current passing through the device. This effect can be used as a sensitive probe of temperature changes on the microscale. These studies establish the MMFT as an effective tool for applying precise forces to membranes at controlled rates and quantitatively studying membrane mechanical and thermo-mechanical properties.

  6. Evaluation of magnetic resonance imaging issues for implantable microfabricated magnetic actuators.

    Science.gov (United States)

    Lee, Hyowon; Xu, Qing; Shellock, Frank G; Bergsneider, Marvin; Judy, Jack W

    2014-02-01

    The mechanical robustness of microfabricated torsional magnetic actuators in withstanding the strong static fields (7 T) and time-varying field gradients (17 T/m) produced by an MR system was studied in this investigation. The static and dynamic mechanical characteristics of 30 devices were quantitatively measured before and after exposure to both strong uniform and non-uniform magnetic fields. The results showed no statistically significant change in both the static and dynamic mechanical performance, which mitigate concerns about the mechanical stability of these devices in association with MR systems under the conditions used for this assessment. The MR-induced heating was also measured in a 3-T/128-MHz MR system. The results showed a minimal increase (1.6 °C) in temperature due to the presence of the magnetic microactuator array. Finally, the size of the MR-image artifacts created by the magnetic microdevices were quantified. The signal loss caused by the devices was approximately four times greater than the size of the device.

  7. Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes

    Science.gov (United States)

    Faivre-Moskalenko, Cendrine; Dogterom, Marileen

    2002-01-01

    Recent in vivo as well as in vitro experiments have indicated that microtubule pushing alone is sufficient to position a microtubule-organizing center within a cell. Here, we investigate the effect of catastrophes on the dynamics of microtubule asters within microfabricated chambers that mimic the confining geometry of living cells. The use of a glass bead as the microtubule-organizing center allows us to manipulate the aster by using optical tweezers. In the case in which microtubules preexist, we show that because of microtubule buckling, repositioning almost never occurs after relocation with the optical tweezers, although initial microtubule growth always leads the aster to the geometrical center of the chamber. When a catastrophe promoter is added, we find instead that the aster is able to efficiently explore the chamber geometry even after being relocated with the optical tweezers. As predicted by theoretical calculations, the results of our in vitro experiments clearly demonstrate the need for catastrophes for proper positioning in a confining geometry. These findings correlate with recent observations of nuclear positioning in fission yeast cells. PMID:12486218

  8. Microfabricated pseudocapacitors using Ni(OH)2 electrodes exhibit remarkable volumetric capacitance and energy density

    KAUST Repository

    Kurra, Narendra

    2014-09-10

    Metal hydroxide based microfabricated pseudocapacitors with impressive volumetric stack capacitance and energy density are demonstrated. A combination of top-down photolithographic process and bottom-up chemical synthesis is employed to fabricate the micro-pseudocapacitors (μ-pseudocapacitors). The resulting Ni(OH)2-based devices show several excellent characteristics including high-rate redox activity up to 500 V s-1 and an areal cell capacitance of 16 mF cm-2 corresponding to a volumetric stack capacitance of 325 F cm-3. This volumetric capacitance is two-fold higher than carbon and metal oxide based μ-supercapacitors with interdigitated electrode architecture. Furthermore, these μ-pseudocapacitors show a maximum energy density of 21 mWh cm-3, which is superior to the Li-based thin film batteries. The heterogeneous growth of Ni(OH)2 over the Ni surface during the chemical bath deposition is found to be the key parameter in the formation of uniform monolithic Ni(OH)2 mesoporous nanosheets with vertical orientation, responsible for the remarkable properties of the fabricated devices. Additionally, functional tandem configurations of the μ-pseudocapacitors are shown to be capable of powering a light-emitting diode.

  9. Cell Sheet-Based Tissue Engineering for Organizing Anisotropic Tissue Constructs Produced Using Microfabricated Thermoresponsive Substrates.

    Science.gov (United States)

    Takahashi, Hironobu; Okano, Teruo

    2015-11-18

    In some native tissues, appropriate microstructures, including orientation of the cell/extracellular matrix, provide specific mechanical and biological functions. For example, skeletal muscle is made of oriented myofibers that is responsible for the mechanical function. Native artery and myocardial tissues are organized three-dimensionally by stacking sheet-like tissues of aligned cells. Therefore, to construct any kind of complex tissue, the microstructures of cells such as myotubes, smooth muscle cells, and cardiomyocytes also need to be organized three-dimensionally just as in the native tissues of the body. Cell sheet-based tissue engineering allows the production of scaffold-free engineered tissues through a layer-by-layer construction technique. Recently, using microfabricated thermoresponsive substrates, aligned cells are being harvested as single continuous cell sheets. The cell sheets act as anisotropic tissue units to build three-dimensional tissue constructs with the appropriate anisotropy. This cell sheet-based technology is straightforward and has the potential to engineer a wide variety of complex tissues. In addition, due to the scaffold-free cell-dense environment, the physical and biological cell-cell interactions of these cell sheet constructs exhibit unique cell behaviors. These advantages will provide important clues to enable the production of well-organized tissues that closely mimic the structure and function of native tissues, required for the future of tissue engineering. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues

    Directory of Open Access Journals (Sweden)

    Zhizhi Zhou

    2017-09-01

    Full Text Available We provide a facile and low-cost method (F-L to fabricate a two-dimensional positive master using a milling technique for polydimethylsiloxane (PDMS-based microchannel molding. This method comprises the following steps: (1 a positive microscale master of the geometry is milled on to an acrylic block; (2 pre-cured PDMS is used to mold the microscale positive master; (3 the PDMS plate is peeled off from the master and punctured with a blunt needle; and (4 the PDMS plate is O2 plasma bonded to a glass slide. Using this technique, we can fabricate microchannels with very simple protocols quickly and inexpensively. This method also avoids breakage of the end mill (ϕ = 0.4 mm of the computerized numerical control (CNC system when fabricating the narrow channels (width < 50 µm. The prominent surface roughness of the milled bottom-layer could be overcomed by pre-cured PDMS with size trade-off in design. Finally, emulsion formation successfully demonstrates the validity of the proposed fabrication protocol. This work represents an important step toward the use of a milling technique for PDMS-based microfabrication.

  11. Microfabricated rubidium vapour cell with a thick glass core for small-scale atomic clock applications

    Science.gov (United States)

    Pétremand, Y.; Affolderbach, C.; Straessle, R.; Pellaton, M.; Briand, D.; Mileti, G.; de Rooij, N. F.

    2012-02-01

    This paper presents a new fabrication method to manufacture alkali reference cells having dimensions larger than standard micromachined cells and smaller than glass-blown ones, for use in compact atomic devices such as vapour-cell atomic clocks or magnetometers. The technology is based on anodic bonding of silicon and relatively thick glass wafers and fills a gap in cell sizes and technologies available up to now: on one side, microfabrication technologies with typical dimensions ≤ 2 mm and on the other side, classical glass-blowing technologies for typical dimensions of about 6-10 mm or larger. The fabrication process is described for cells containing atomic Rb and spectroscopic measurements (optical absorption spectrum and double resonance) are reported. The analysis of the bonding strength of our cells was performed and shows that the first anodic bonding steps exhibit higher bonding strengths than the later ones. The spectroscopic results show a good quality of the cells. From the double-resonance signals, we predict a clock stability of ≈3 × 10-11 at 1 s of integration time, which compares well to the performance of compact commercial Rb atomic clocks.

  12. A Microfabricated 96-Well 3D Assay Enabling High-Throughput Quantification of Cellular Invasion Capabilities

    Science.gov (United States)

    Hao, Rui; Wei, Yuanchen; Li, Chaobo; Chen, Feng; Chen, Deyong; Zhao, Xiaoting; Luan, Shaoliang; Fan, Beiyuan; Guo, Wei; Wang, Junbo; Chen, Jian

    2017-01-01

    This paper presents a 96-well microfabricated assay to study three-dimensional (3D) invasion of tumor cells. A 3D cluster of tumor cells was first generated within each well by seeding cells onto a micro-patterned surface consisting of a central fibronectin-coated area that promotes cellular attachment, surrounded by a poly ethylene glycol (PEG) coated area that is resistant to cellular attachment. Following the formation of the 3D cell clusters, a 3D collagen extracellular matrix was formed in each well by thermal-triggered gelation. Invasion of the tumor cells into the extracellular matrix was subsequently initiated and monitored. Two modes of cellular infiltration were observed: A549 cells invaded into the extracellular matrix following the surfaces previously coated with PEG molecules in a pseudo-2D manner, while H1299 cells invaded into the extracellular matrix in a truly 3D manner including multiple directions. Based on the processing of 2D microscopic images, a key parameter, namely, equivalent invasion distance (the area of invaded cells divided by the circumference of the initial cell cluster) was obtained to quantify migration capabilities of these two cell types. These results validate the feasibility of the proposed platform, which may function as a high-throughput 3D cellular invasion assay. PMID:28240272

  13. Microfabricated sensors for the measurement of electromagnetic fields in biological tissues

    Science.gov (United States)

    Monberg, James; Henning, Albert K.

    1995-09-01

    Public awareness of the risks of exposure to electromagnetic radiation has grown over the past ten yeras. The effects of power lines on human and animal health have drawn particular attention. Some longitudinal studies of cancer rates near power lines show a significant correlation, while others show a null result. The studies have suffered from inadequate sensors for the measurement of electromagnetic radiation in vivo. In this work, we describe the design, construction, and testing of electrically passive, microfabricated single-pole antennas and coils. These sensors will be used in vivo to study the effects of electromagnetic radiation on animals. Our testing to date has been limited to in vitro studies of the magnetic field probes. Magnetic field pickup coils were fabricated with up to 100 turns, over a length of up to 1000 micrometers . Measurements were carried out with the sensors in air, and in water of various saline concentrations. Magnetic fields were applied using a Helmholtz coil. Both dc and ac fields were applied. The results indicate that small-area measurements of electromagnetic fields in vitro can be made successfully, provided adequate shielding and amplification are used.

  14. Towards experimental realization of a scalable ion chain quantum processor in microfabricated surface trap

    Science.gov (United States)

    Baek, So-Young; Mount, Emily; Gaultney, Daniel; Noek, Rachel; Crain, Stephen; van Rynbach, Andre; Maunz, Peter; Kim, Jungsang

    2012-06-01

    Realization of a practical trapped ion quantum information processor is a major technological challenge that requires development of large-scale integration approaches. The integration technology must include scalable solution for both the qubit datapath and classical controllers necessary to manipulate them. Our approach utilizes linear ion chains in microfabricated surface traps as a platform to store Yb ion qubits and operate quantum logic gates on them. The control signals for qubit manipulation include the abilities to direct precisely tailored laser beams to individual ions, re-arranging the ions in the chains, and parallel detection of multiple qubits. We use a frequency comb generated by an off-resonant picosecond pulsed laser with stabilized repetition rate to drive Raman transitions, realizing single qubit and multiple qubit gates in an inherently scalable way. The laser beams will be delivered to individual ions using a microelectromechanical systems-based beam steering system that can easily be extended to multiple beams, and the parallel state detection will be performed using multi-element photomultiplier tube array. We will describe the experimental progress in implementing basic quantum information processing protocols in this system.

  15. Entrapment of bed bugs by leaf trichomes inspires microfabrication of biomimetic surfaces.

    Science.gov (United States)

    Szyndler, Megan W; Haynes, Kenneth F; Potter, Michael F; Corn, Robert M; Loudon, Catherine

    2013-06-06

    Resurgence in bed bug infestations and widespread pesticide resistance have greatly renewed interest in the development of more sustainable, environmentally friendly methods to manage bed bugs. Historically, in Eastern Europe, bed bugs were entrapped by leaves from bean plants, which were then destroyed; this purely physical entrapment was related to microscopic hooked hairs (trichomes) on the leaf surfaces. Using scanning electron microscopy and videography, we documented the capture mechanism: the physical impaling of bed bug feet (tarsi) by these trichomes. This is distinct from a Velcro-like mechanism of non-piercing entanglement, which only momentarily holds the bug without sustained capture. Struggling, trapped bed bugs are impaled by trichomes on several legs and are unable to free themselves. Only specific, mechanically vulnerable locations on the bug tarsi are pierced by the trichomes, which are located at effective heights and orientations for bed bug entrapment despite a lack of any evolutionary association. Using bean leaves as templates, we microfabricated surfaces indistinguishable in geometry from the real leaves, including the trichomes, using polymers with material properties similar to plant cell walls. These synthetic surfaces snag the bed bugs temporarily but do not hinder their locomotion as effectively as real leaves.

  16. Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications

    Directory of Open Access Journals (Sweden)

    Andres Garcia

    2012-01-01

    Full Text Available Particle Replication in Non-Wetting Templates (PRINT® is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.

  17. A microfabricated low-profile wideband antenna array for terahertz communications.

    Science.gov (United States)

    Luk, K M; Zhou, S F; Li, Y J; Wu, F; Ng, K B; Chan, C H; Pang, S W

    2017-04-28

    While terahertz communications are considered to be the future solutions for the increasing demands on bandwidth, terahertz equivalents of radio frequency front-end components have not been realized. It remains challenging to achieve wideband, low profile antenna arrays with highly directive beams of radiation. Here, based on the complementary antenna approach, a wideband 2 × 2 cavity-backed slot antenna array with a corrugated surface is proposed. The approach is based on a unidirectional antenna with a cardiac radiation pattern and stable frequency characteristics that is achieved by integrating a series-resonant electric dipole with a parallel-resonant magnetic dipole. In this design, the slots work as magnetic dipoles while the corrugated surface radiates as an array of electric dipoles. The proposed antenna is realized at 1 THz operating frequency by stacking multiple metallized layers using the microfabrication technology. S-parameter measurements of this terahertz low-profile metallic antenna array demonstrate high efficiency at terahertz frequencies. Fractional bandwidth and gain are measured to be 26% and 14 dBi which are consistent with the simulated results. The proposed antenna can be used as the building block for larger antenna arrays with more directive beams, paving the way to develop high gain low-profile antennas for future communication needs.

  18. Microfabrication Technology for Large Lekid Arrays: From Nika2 to Future Applications

    Science.gov (United States)

    Goupy, J.; Adane, A.; Benoit, A.; Bourrion, O.; Calvo, M.; Catalano, A.; Coiffard, G.; Hoarau, C.; Leclercq, S.; Le Sueur, H.; Macias-Perez, J.; Monfardini, A.; Peck, I.; Schuster, K.

    2016-08-01

    The lumped element kinetic inductance detectors (LEKID) demonstrated full maturity in the New IRAM KID Arrays (NIKA) instrument. These results allow directly comparing LEKID performance with other competing technologies (TES, doped silicon) in the mm and sub-mm range. A continuing effort is ongoing to improve the microfabrication technologies and concepts in order to satisfy the requirements of new instruments. More precisely, future satellites dedicated to cosmic microwave background (CMB) studies will require the same focal plane technology to cover, at least, the frequency range of 60-600 GHz. Aluminium LEKID developed for NIKA have so far demonstrated, under real telescope conditions, a performance approaching photon noise limitation in the band 120-300 GHz. By implementing superconducting bi-layers, we recently demonstrated LEKID arrays working in the range 80-120 GHz and with sensitivities approaching the goals for CMB missions. NIKA itself (350 pixels) is followed by a more ambitious project requiring several thousand (3000-5000) pixels. NIKA2 has been installed in October 2015 at the IRAM 30-m telescope. We will describe in detail the technological improvements that allowed a relatively harmless tenfold up-scaling in pixels count without degrading the initial sensitivity. In particular, we will briefly describe a solution to simplify the difficult fabrication step linked to the slot-line propagation mode in coplanar waveguide.

  19. Microfabrication and integration of a sol-gel PZT folded spring energy harvester.

    Science.gov (United States)

    Lueke, Jonathan; Badr, Ahmed; Lou, Edmond; Moussa, Walied A

    2015-05-26

    This paper presents the methodology and challenges experienced in the microfabrication, packaging, and integration of a fixed-fixed folded spring piezoelectric energy harvester. A variety of challenges were overcome in the fabrication of the energy harvesters, such as the diagnosis and rectification of sol-gel PZT film quality and adhesion issues. A packaging and integration methodology was developed to allow for the characterizing the harvesters under a base vibration. The conditioning circuitry developed allowed for a complete energy harvesting system, consisting a harvester, a voltage doubler, a voltage regulator and a NiMH battery. A feasibility study was undertaken with the designed conditioning circuitry to determine the effect of the input parameters on the overall performance of the circuit. It was found that the maximum efficiency does not correlate to the maximum charging current supplied to the battery. The efficiency and charging current must be balanced to achieve a high output and a reasonable output current. The development of the complete energy harvesting system allows for the direct integration of the energy harvesting technology into existing power management schemes for wireless sensing.

  20. Zinc Detection in Serum by Anodic Stripping Voltammetry on Microfabricated Bismuth Electrodes.

    Science.gov (United States)

    Jothimuthu, Preetha; Wilson, Robert A; Herren, Josi; Pei, Xing; Kang, Wenjing; Daniels, Rodney; Wong, Hector; Beyette, Fred; Heineman, William R; Papautsky, Ian

    2013-02-01

    Zinc (Zn) homeostasis is required for a functional immune system. Critically ill patients often exhibit decreased Zn serum concentrations and could potentially benefit from Zn supplementation as a therapeutic strategy. However, the conventional approaches to monitoring Zn are time consuming and costly. This work reports on detection of Zn by anodic stripping voltammetry (ASV) on bismuth electrodes in a microfabricated electrochemical cell. The working potential window of the electrodeposited bismuth film electrode was investigated by cyclic voltammetry, while square wave ASV was used for measuring Zn in acetate buffer and blood serum. Conditions critical to sensing, such as preconcentration potential, preconcentration time, and buffer pH, were optimized for Zn detection. The sensor was successfully calibrated with pH 6 acetate buffer in the physiologically-relevant range of 5 μM to 50μM Zn and exhibited well-defined and highly repeatable peaks. The sensor was used to demonstrate measurement of Zn in blood serum digested in HCl. The results of this work show that Zn detection in serum is possible with smaller sample volumes (μL vs. μL) and faster turnaround time (hours vs. days) as compared with the conventional spectroscopic methods.

  1. A microfabricated sun sensor using GaN-on-sapphire ultraviolet photodetector arrays

    Science.gov (United States)

    Miller, Ruth A.; So, Hongyun; Chiamori, Heather C.; Suria, Ateeq J.; Chapin, Caitlin A.; Senesky, Debbie G.

    2016-09-01

    A miniature sensor for detecting the orientation of incident ultraviolet light was microfabricated using gallium nitride (GaN)-on-sapphire substrates and semi-transparent interdigitated gold electrodes for sun sensing applications. The individual metal-semiconductor-metal photodetector elements were shown to have a stable and repeatable response with a high sensitivity (photocurrent-to-dark current ratio (PDCR) = 2.4 at -1 V bias) and a high responsivity (3200 A/W at -1 V bias) under ultraviolet (365 nm) illumination. The 3 × 3 GaN-on-sapphire ultraviolet photodetector array was integrated with a gold aperture to realize a miniature sun sensor (1.35 mm × 1.35 mm) capable of determining incident light angles with a ±45° field of view. Using a simple comparative figure of merit algorithm, measurement of incident light angles of 0° and 45° was quantitatively and qualitatively (visually) demonstrated by the sun sensor, supporting the use of GaN-based sun sensors for orientation, navigation, and tracking of the sun within the harsh environment of space.

  2. Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography.

    Science.gov (United States)

    Gauvin, Robert; Chen, Ying-Chieh; Lee, Jin Woo; Soman, Pranav; Zorlutuna, Pinar; Nichol, Jason W; Bae, Hojae; Chen, Shaochen; Khademhosseini, Ali

    2012-05-01

    The success of tissue engineering will rely on the ability to generate complex, cell seeded three-dimensional (3D) structures. Therefore, methods that can be used to precisely engineer the architecture and topography of scaffolding materials will represent a critical aspect of functional tissue engineering. Previous approaches for 3D scaffold fabrication based on top-down and process driven methods are often not adequate to produce complex structures due to the lack of control on scaffold architecture, porosity, and cellular interactions. The proposed projection stereolithography (PSL) platform can be used to design intricate 3D tissue scaffolds that can be engineered to mimic the microarchitecture of tissues, based on computer aided design (CAD). The PSL system was developed, programmed and optimized to fabricate 3D scaffolds using gelatin methacrylate (GelMA). Variation of the structure and prepolymer concentration enabled tailoring the mechanical properties of the scaffolds. A dynamic cell seeding method was utilized to improve the coverage of the scaffold throughout its thickness. The results demonstrated that the interconnectivity of pores allowed for uniform human umbilical vein endothelial cells (HUVECs) distribution and proliferation in the scaffolds, leading to high cell density and confluency at the end of the culture period. Moreover, immunohistochemistry results showed that cells seeded on the scaffold maintained their endothelial phenotype, demonstrating the biological functionality of the microfabricated GelMA scaffolds.

  3. Microfabrication of proangiogenic cell-laden alginate-g-pyrrole hydrogels.

    Science.gov (United States)

    DeVolder, Ross J; Zill, Andrew T; Jeong, Jae H; Kong, Hyunjoon

    2012-11-01

    Cells have been extensively studied for their uses in various therapies because of their capacities to produce therapeutic proteins and recreate new tissues. It has often been suggested that the efficacy of cell therapies can greatly be improved through the ability to localize and regulate cellular activities at a transplantation site; however, the technologies for this control are lacking. Therefore, this study reports a cell-Laden hydrogel patch engineered to support the proliferation and angiogenic growth factor expression of cells adhered to their surfaces, and to further promote neovascularization. Hydrogels consisting of alginate chemically linked with pyrrole units, termed alginate-g-pyrrole, were prepared through an oxidative cross-linking reaction between pyrrole units. Fibroblasts adhered to the alginate-g-pyrrole hydrogels, and exhibited increased proliferation and overall vascular endothelial growth factor (VEGF) expression, compared to those on pyrrole-free hydrogels. Furthermore, the alginate-g-pyrrole hydrogel surfaces were modified to present microposts, subsequently increasing the amount of pyrrole units on their surfaces. Cells adhered to the microfabricated gel surfaces exhibited increased proliferation and overall VEGF expression proportional to the density of the microposts. The resulting micropatterned alginate-g-pyrrole hydrogels exhibited increases in the size and density of mature blood vessels when implanted on chick chorioallantoic membranes (CAMs). The hydrogel system developed in this study will be broadly useful for improving the efficacy of a wide array of cell-based wound healing and tissue regenerative therapies.

  4. A Microfabricated 8-40 GHz Dual-Polarized Reflector Feed

    Science.gov (United States)

    Vanhille, Kenneth; Durham, Tim; Stacy, William; Karasiewicz, David; Caba, Aaron; Trent, Christopher; Lambert, Kevin; Miranda, Felix

    2014-01-01

    Planar antennas based on tightly coupled dipole arrays (also known as a current sheet antenna or CSA) are amenable for use as electronically scanned phased arrays. They are capable of performance nearing a decade of bandwidth. These antennas have been demonstrated in many implementations at frequencies below 18 GHz. This paper describes the implementation using a relatively new multi-layer microfabrication process resulting in a small, 6x6 element, dual-linear polarized array with beamformer that operates from 8 to 40 GHz. The beamformer includes baluns that feed the dual-polarized differential antenna elements and reactive splitter networks that also cover the full frequency range of operation. This antenna array serves as a reflector feed for a multi-band instrument designed to measure snow water equivalent (SWE) from airborne platforms. The instrument has both radar and radiome try capability at multiple frequencies. Scattering-parameter and time-domain measurements have been used to characterize the array feed. Radiation patterns of the antenna have been measured and are compared to simulation. To the best of the authors' knowledge, this work represents the most integrated multi-octave millimeter-wave antenna feed fabricated to date.

  5. Microstructural control over soluble pentacene deposited by capillary pen printing for organic electronics.

    Science.gov (United States)

    Lee, Wi Hyoung; Min, Honggi; Park, Namwoo; Lee, Junghwi; Seo, Eunsuk; Kang, Boseok; Cho, Kilwon; Lee, Hwa Sung

    2013-08-28

    Research into printing techniques has received special attention for the commercialization of cost-efficient organic electronics. Here, we have developed a capillary pen printing technique to realize a large-area pattern array of organic transistors and systematically investigated self-organization behavior of printed soluble organic semiconductor ink. The capillary pen-printed deposits of organic semiconductor, 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS_PEN), was well-optimized in terms of morphological and microstructural properties by using ink with mixed solvents of chlorobenzene (CB) and 1,2-dichlorobenzene (DCB). Especially, a 1:1 solvent ratio results in the best transistor performances. This result is attributed to the unique evaporation characteristics of the TIPS_PEN deposits where fast evaporation of CB induces a morphological evolution at the initial printed position, and the remaining DCB with slow evaporation rate offers a favorable crystal evolution at the pinned position. Finally, a large-area transistor array was facilely fabricated by drawing organic electrodes and active layers with a versatile capillary pen. Our approach provides an efficient printing technique for fabricating large-area arrays of organic electronics and further suggests a methodology to enhance their performances by microstructural control of the printed organic semiconducting deposits.

  6. [Histopathology of meibomian gland abnormalities in experimental PenCB intoxicated beagle treated with squalane].

    Science.gov (United States)

    Kohno, T; Ohnishi, Y

    1989-05-01

    In order to examine the effect of squalane to excrete PCB from the intoxicated animals, histopathological studies of Meibomian gland abnormalities were carried out in experimental PenCB (3,4,5,3',4'-pentachlorobiphenyl) intoxicated beagles treated with squalane. All experimental animals except a control group showed characteristic changes of Meibomian glands: dilation of the duct and squamous metaplasia of the alveolar cells. According to the degree of these findings, five stages were divided in the processes of Medibomian gland changes. The PenCB intoxicated dogs initially showed mild pathological changes of the glands and later moderate to severe degrees of findings. In the PenCB intoxicated animals treated with squalane, severe degree of Meibomian gland findings were found in the early stage and mild to moderate abnormalities in the late stage. The concentration of PenCB in blood varied in each animal, and the animals with advanced Medibomian gland abnormalities tended to have high level of PenCB concentration in blood. In conclusion, the effect of squalane to excrete PCB from the intoxicated animals were not determined in this study.

  7. Behavioral, thermoregulatory, and operational aspects of shallow pool pens used in gilts production

    Directory of Open Access Journals (Sweden)

    Heverton Michael Biazzi

    2014-12-01

    Full Text Available This work was conducted to assess behaviors, thermoregulatory, and operational aspects of gilt breeding (Body weight, 25–110 kg whilst the animals were housed in 2-cm deep shallow pool pens (SPP, without the addition of water, compared to the use of fully compact floor pens (TSF during the winter and summer seasons. Commercial female strains for high lean tissue accretion were used, housed in grower/finisher pens for 108 days (11 animals/pen, 1.2 m2/animal. Instantaneous observations of behavior were carried out every 12 min between 7:00 and 19:00 hours throughout the six days of the raising period. At the end of the raising period, the operational aspects of cleaning the facilities were analyzed. A 2 × 2 factorial scheme design was used, with two types of floors and two seasons, with three replicates. The average temperatures in winter and summer were 19.9 ± 2.2°C and 24.5 ± 2.3°C, respectively. The use of SPP reduced aggressive behavior and increased exploratory behavior, increased the time for the daily cleaning, and reduced the time for the final cleaning of the pens.

  8. Pen-based remote data entry system. A pilot clinical trial.

    Science.gov (United States)

    Beinlich, I; Bokemeyer, C; Räth, U; Walter-Kirst, R; Hartlapp, J; Muschiol, J; Fraass, U; Schneider, H T

    1993-03-01

    This study assesses the feasibility of pen-based remote data entry and measures the acceptance of such systems by patients and physicians. Three clinical investigators participated in a phase-I/II clinical trial of escalated doses of chemotherapy followed by Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The study included 20 patients with testicular cancer who were treated at three university hospitals. The patients' data obtained in this trial were recorded and stored on a pen-based computer system. A total of 798 data points were recorded for each patient using 33 electronic forms resembling the paper forms used during an earlier phase of the study. The data recorded include the past medical history, inclusion/exclusion criteria, disease staging, therapy documentation, laboratory values and side effects. Both physicians and patients were interviewed directly after using the pen-based remote data entry system. Patients accepted that their physician was taking notes on an electronic form rather than on paper. All patients noted that a pen-based system is superior to a desktop computer when used during an interview. For the investigators electronic data entry takes additional effort, but time savings are realized later with less data clearing and increased data quality. These benefits are important for the study sponsor as well. In conclusion, pen-based remote data entry is a feasible new mode of recording clinical data with concrete benefits to both investigators and sponsors.

  9. The Possible Role of Penning Ionization Processes in Planetary Atmospheres

    Directory of Open Access Journals (Sweden)

    Stefano Falcinelli

    2015-03-01

    Full Text Available In this paper we suggest Penning ionization as an important route of formation for ionic species in upper planetary atmospheres. Our goal is to provide relevant tools to researchers working on kinetic models of atmospheric interest, in order to include Penning ionizations in their calculations as fast processes promoting reactions that cannot be neglected. Ions are extremely important for the transmission of radio and satellite signals, and they govern the chemistry of planetary ionospheres. Molecular ions have also been detected in comet tails. In this paper recent experimental results concerning production of simple ionic species of atmospheric interest are presented and discussed. Such results concern the formation of free ions in collisional ionization of H2O, H2S, and NH3 induced by highly excited species (Penning ionization as metastable noble gas atoms. The effect of Penning ionization still has not been considered in the modeling of terrestrial and extraterrestrial objects so far, even, though metastable helium is formed by radiative recombination of He+ ions with electrons. Because helium is the second most abundant element of the universe, Penning ionization of atomic or molecular species by He*(23S1 is plausibly an active route of ionization in relatively dense environments exposed to cosmic rays.

  10. Field-scale evaluation of water fluxes and manure solution leaching in feedlot pen soils.

    Science.gov (United States)

    García, Ana R; Maisonnave, Roberto; Massobrio, Marcelo J; Fabrizio de Iorio, Alicia R

    2012-01-01

    Accumulation of beef cattle manure on feedlot pen surfaces generates large amounts of dissolved solutes that can be mobilized by water fluxes, affecting surface and groundwater quality. Our objective was to examine the long-term impacts of a beef cattle feeding operation on water fluxes and manure leaching in feedlot pens located on sandy loam soils of the subhumid Sandy Pampa region in Argentina. Bulk density, gravimetric moisture content, and chloride concentration were quantified. Rain simulation trials were performed to estimate infiltration and runoff rates. Using chloride ion as a tracer, profile analysis techniques were applied to estimate the soil moisture flux and manure conservative chemical components leaching rates. An organic stratum was found over the surface of the pen soil, separated from the underlying soil by a highly compacted thin layer (the manure-soil interface). The soil beneath the organic layer showed greater bulk density in the A horizon than in the control soil and had greater moisture content. Greater concentrations of chloride were found as a consequence of the partial sealing of the manure-soil interface. Surface runoff was the dominant process in the feedlot pen soil, whereas infiltration was the main process in control soil. Soil moisture flux beneath pens decreased substantially after 15 yr of activity. The estimated minimum leaching rate of chloride was 13 times faster than the estimated soil moisture flux. This difference suggests that chloride ions are not exclusively transported by advective flow under our conditions but also by solute diffusion and preferential flow.

  11. Preferences of lame cows for type of surface and level of social contact in hospital pens

    DEFF Research Database (Denmark)

    Jensen, Margit Bak; Herskin, Mette S; Thomsen, Peter T.

    2015-01-01

    in a neighboring pen. These results suggest that provision of a deep-bedded lying area in hospital pens is important to the welfare of lame cows. We found no evidence of isolation-seeking behavior in animals with these diagnoses (and no systemic symptoms) while they were kept in individual hospital pens.......To investigate preferences of lame cows for flooring and level of social contact, 37 lame, lactating dairy cows (diagnosed with sole ulcer or white line disease) were housed individually for 6 d in experimental hospital pens, where they could choose between 2 equally sized areas (6m × 4.5m......) with either deep-bedded sand or a rubber surface. On both surfaces, cows could choose between 2 equally sized areas either near or away from heifers in a neighboring group pen. Cows spent more time lying on the deep-bedded sand than on the rubber surface (870 vs. 71min/d), whereas they spent less time upright...

  12. A Prototype of Mathematical Treatment of Pen Pressure Data for Signature Verification.

    Science.gov (United States)

    Li, Chi-Keung; Wong, Siu-Kay; Chim, Lai-Chu Joyce

    2017-03-26

    A prototype using simple mathematical treatment of the pen pressure data recorded by a digital pen movement recording device was derived. In this study, a total of 48 sets of signature and initial specimens were collected. Pearson's correlation coefficient was used to compare the data of the pen pressure patterns. From the 820 pair comparisons of the 48 sets of genuine signatures, a high degree of matching was found in which 95.4% (782 pairs) and 80% (656 pairs) had rPA > 0.7 and rPA > 0.8, respectively. In the comparison of the 23 forged signatures with their corresponding control signatures, 20 of them (89.2% of pairs) had rPA values prototype could be used as a complementary technique to improve the objectivity of signature examination and also has a good potential to be developed as a tool for automated signature identification.

  13. Efficacy of monensin against turkey coccidiosis in laboratory and floor-pen experiments.

    Science.gov (United States)

    Anderson, W I; Reid, W M; McDougald, L R

    1976-01-01

    Monensin at 60, 80, or 100 ppm in feed reduced mortality and lesion scores while protecting against weight loss of turkeys infected with the major pathogenic species: Eimeria adenoides, E. meleagrimitis, and E. gallopavonis. With single and mixed infections in battery-cage experiments, the death rate of unmedicated turkey poults was 33-75%. Weight gains were significantly (P is less than or equal to 0.05) better with 100 ppm monensin than 60 ppm, as were also lesion scores. Under floor-pen conditions there were no significant differences among monensin treatments. Moisture content of the litter was significantly lower in all monensin-medicated pens (40%, compared with 52% moisture in pens of unmedicated controls).

  14. Distribución de Arum cylindraceum Gasp. (Araceae en la Península Iberica

    Directory of Open Access Journals (Sweden)

    Draper, David

    1997-12-01

    Full Text Available Following the revisión of herbarium material, a map (CUTM is presented of the distribution on the Iberian Península of Arum cylindraceum Gasp. (Araceae, which is new to Portugal. It is concluded that A. maculatum L. is reponed infrequently on the Península an that detailed studies are necessary to establish its correct distribution.Como resultado de la revisión de materiales de herbario, se presenta un mapa (CUTM con la distribución peninsular de Arum cylindraceum Gasp. (Araceae, el cual es novedad para Portugal. Se concluye que Arum maculatum L. se encuentra muy poco representado en la Península Ibérica y que precisa de estudios más detallados, para poder determinar su correcta distribución.

  15. [Analysis of writing age of ballpoint pen ink by thin-layer chromatography].

    Science.gov (United States)

    Zhao, P C; Wang, Y J; Cui, L; Shi, X F; Wang, Y H

    2001-07-01

    A method based on using a thin-layer chromatographic method (TLC) for determining changes in dye of ballpoint pen ink developed with writing age. An ink drawn line of 1 cm in length was cut and placed in Eppendorf tube. Extraction was performed with 20 microL ethanol at room temperature for 15 min, and heated in steambath for 10 min. The ethanol solution(4 microL) containing the extracted dyes was then spotted on TLC plate by syringe after cooling. The ballpoint pen ink spots were eluted in a solvent of isopropyl alcohol. Using TLC scanner, the spots on TLC plate were scanned at 580 nm. The relations between ratio of peak heights and writing age were attained. Thus, the information on relative writing age can be obtained. And, the powerful evidence for identifying the age of ballpoint pen ink is provided by this method in the field of forensic science.

  16. Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters

    DEFF Research Database (Denmark)

    Præstmark, Kezia Ann; Stallknecht, Bente Merete; Bo Jensen, Casper

    2014-01-01

    Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating...... skin blood perfusion response around needle insertion sites. Three common sized pen needles of 28G, 30G, and 32G as well as hooked 32G needles, were inserted into the neck skin of pigs and then removed. Laser Speckle Contrast Analysis was used to measure skin blood perfusion for 20 minutes after......, but there was a trend of an increased response with increasing needle diameter. Skin blood perfusion response to pen needle insertions rank according to needle diameter, and the tissue response caused by hooked 32G needles corresponds to that of 28G needles. The relation between needle diameter and trauma when...

  17. High resolution, shallow seismic reflection survey of the Pen Branch fault

    Energy Technology Data Exchange (ETDEWEB)

    Stieve, A.

    1991-05-15

    The purpose of this project, at the Savannah River River Site (SRS) was to acquire, process, and interpret 28 km (17.4 miles) of high resolution seismic reflection data taken across the trace of the Pen Branch fault and other suspected, intersecting north-south trending faults. The survey was optimized for the upper 300 ft of geologic strata in order to demonstrate the existence of very shallow, flat lying horizons, and to determine the depth of the fault or to sediments deformed by the fault. Field acquisition and processing parameters were selected to define small scale spatial variability and structural features in the vicinity of the Pen Branch fault leading to the definition and the location of the Pen Branch fault, the shallowest extent of the fault, and the quantification of the sense and magnitude of motion. Associated geophysical, borehole, and geologic data were incorporated into the investigation to assist in the determination of optimal parameters and aid in the interpretation.

  18. Classical calculation of relativistic frequency-shifts in an ideal Penning trap

    CERN Document Server

    Ketter, Jochen; Höcker, Martin; Schuh, Marc; Streubel, Sebastian; Blaum, Klaus

    2013-01-01

    The ideal Penning trap consists of a uniform magnetic field and an electrostatic quadrupole potential. In the classical low-energy limit, the three characteristic eigenfrequencies of a charged particle trapped in this configuration do not depend on the amplitudes of the three eigenmotions. No matter how accurate the experimental realization of the ideal Penning trap, its harmonicity is ultimately compromised by special relativity. Using a classical formalism of first-order perturbation theory, we calculate the relativistic frequency-shifts associated with the motional degrees of freedom for a spinless particle stored in an ideal Penning trap, and we compare the results with the simple but surprisingly accurate model of relativistic mass-increase.

  19. Innovation & evaluation of tangible direct manipulation digital drawing pens for children.

    Science.gov (United States)

    Lee, Tai-Hua; Wu, Fong-Gong; Chen, Huei-Tsz

    2017-04-01

    Focusing on the theme of direct manipulation, in this study, we proposed a new and innovative tangible user interface (TUI) design concept for a manipulative digital drawing pen. Based on interviews with focus groups brainstorming and experts and the results of a field survey, we selected the most suitable tangible user interface for children between 4 and 7 years of age. Using the new tangible user interface, children could choose between the brush tools after touching and feeling the various patterns. The thickness of the brush could be adjusted by changing the tilt angle. In a subsequent experimental process we compared the differences in performance and subjective user satisfaction. A total of sixteen children, aged 4-7 years participated in the experiment. Two operating system experiments (the new designed tangible digital drawing pen and traditional visual interface-icon-clicking digital drawing pens) were performed at random and in turns. We assessed their manipulation performance, accuracy, brush stroke richness and subjective evaluations. During the experimental process we found that operating functions using the direct manipulation method, and adding shapes and semantic models to explain the purpose of each function, enabled the children to perform stroke switches relatively smoothly. By using direct manipulation digital pens, the children could improve their stroke-switching performance for digital drawing. Additionally, by using various patterns to represent different brushes or tools, the children were able to make selections using their sense of touch, thereby reducing the time required to move along the drawing pens and select icons (The significant differences (p = 0.000, p digital drawing pens.

  20. Pen Rearing and Imprinting of Fall Chinook Salmon, 1985 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Novotny, Jerry F.; Macy, Thomas L.; Gardenier, James T.

    1985-05-01

    Upriver bright fall chinook salmon (Oncorhynchus tshawytscha) are being reared in a backwater and a pond along John Day Reservoir to evaluate the benefits of rearing fish and releasing them off-station compared to traditional hatchery procedures. Fish reared in net pens at a density/feeding combination judged to be the economic optimum of those used during 1984 rearing trials exhibited good growth and smolt development. Size of fish averaged 112 fish/lb (4.0g/fish), ATPase activities ranged from 16.4 to 29.5 micromoles Pi/mg prot/hr at release and total mortality of fish was low among pens, ranging from 0.3 to 1.1%. Poor growth and smolt development was observed in fish reared in a large barrier net, especially during the initial two weeks after stocking. In addition, mortality of fish in the barrier net was high (49%) in relation to any of the other treatments tested thus far. The combined effects of generally poor condition of fish at stocking, low zooplankton densities during the initial two weeks of rearing, and losses to predation were thought to be the primary causes of the slow growth rates and high mortality. Unfed fish in pens utilized the available natural food base, but zooplankton densities were apparently not sufficient for growth, and may have been marginal for sustenance, especially at higher density. ATPase activities at release were significantly higher in low-density pens than in higher density pens, but development at all densities was retarded when compared with ATPase activities of fed fish. Preliminary cost estimates for producing fish-using the rearing strategies developed in the current pen-rearing study compared favorably with the average costs of rearing salmonids in a Northwest hatchery.