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Sample records for micheletti federica olivero

  1. Performance Comparison Between FEDERICA Hand and LARM Hand

    OpenAIRE

    Carbone, Giuseppe; Rossi, Cesare; Savino, Sergio

    2015-01-01

    This paper describes two robotic hands that have been\\ud developed at University Federico II of Naples and at the\\ud University of Cassino. FEDERICA Hand and LARM Hand\\ud are described in terms of design and operational features.\\ud In particular, careful attention is paid to the differences\\ud between the above-mentioned hands in terms of transmission\\ud systems. FEDERICA Hand uses tendons and pulleys\\ud to drive phalanxes, while LARM Hand uses cross four-bar\\ud linkages. Results of experime...

  2. Reality and fiction of an educator of the people. Study of the pedagogical mission of Federica Montseny through her autobiographies

    Directory of Open Access Journals (Sweden)

    Michela Caiazzo

    2014-01-01

    Full Text Available In this work we intend to study, through the analysis of the autobiographical works of the anarchist thinker Federica Montseny (1905-1994, the educational context in which the writer was born and her attempt to transform the society through her own example and writings. The anti-authoritarian and freethinker background, the extended family of overtones inspired by Fourier’s ideal, the rational and secular teachings of her mother Teresa Mañé, the full immersion into the world of politics and workers struggles of the early twentieth century shapes the awareness of a child who will devote her life spreading the anarchist model. Deeply aware of the ethical and social potential of art, she puts into practice her ability to become a writer, a speaker and an educator of the people. Fiction and reality blend aiming to create a heroine. Received: 27/05/2013 / Accepted: 20/06/2013 How to reference this article Caiazzo, M. (2014. Realidad y ficción de una educadora del pueblo. Estudio de la misión pedagógica de Federica Montseny a través de sus autobiografías. Espacio, Tiempo y Educación, 1(1, pp. 77-96. doi: http://dx.doi.org/10.14516/ete.2014.001.001.004

  3. An evolution in listening: An analytical and critical study of structural, acoustic, and phenomenal aspects of selected works by Pauline Oliveros

    Science.gov (United States)

    Setar, Katherine Marie

    1997-08-01

    This dissertation analytically and critically examines composer Pauline Oliveros's philosophy of 'listening' as it applies to selected works created between 1961 and 1984. The dissertation is organized through the application of two criteria: three perspectives of listening (empirical, phenomenal, and, to a lesser extent, personal), and categories derived, in part, from her writings and interviews (improvisational, traditional, theatrical, electronic, meditational, and interactive). In general, Oliveros's works may be categorized by one of two listening perspectives. The 'empirical' listening perspective, which generally includes pure acoustic phenomenon, independent from human interpretation, is exemplified in the analyses of Sound Patterns (1961), OH HA AH (1968), and, to a lesser extent, I of IV (1966). The 'phenomenal' listening perspective, which involves the human interaction with the pure acoustic phenomenon, includes a critical examination of her post-1971 'meditation' pieces and an analytical and critical examination of her tonal 'interactive' improvisations in highly resonant space, such as Watertank Software (1984). The most pervasive element of Oliveros's stylistic evolution is her gradual change from the hierarchical aesthetic of the traditional composer, to one in which creative control is more equally shared by all participants. Other significant contributions by Oliveros include the probable invention of the 'meditation' genre, an emphasis on the subjective perceptions of musical participants as a means to greater musical awareness, her musical exploration of highly resonant space, and her pioneering work in American electronic music. Both analytical and critical commentary were applied to selective representative works from Oliveros's six compositional categories. The analytical methods applied to the Oliveros's works include Wayne Slawson's vowel/formant theory as described in his book, Sound Color, an original method of categorizing consonants as

  4. La agresividad y las capacidades del área de matemática en estudiantes del tercero de secundaria de la institución educativa Saco Oliveros – Helicoidal Ate 2011

    OpenAIRE

    Espinoza Chaca, Carmen Ascenciona; Melissa Wendy Zárate Murga, Melissa Wendy

    2016-01-01

    La presente investigación tiene como objetivo determinar la relación que existe entre la agresividad y las capacidades del área de matemática en estudiantes del tercero de secundaria de la institución educativa Saco Oliveros – Helicoidal Ate 2011 . Para la investigación se utilizó un cuestionario para determinar el nivel de autoestima y actas de evaluación aprendizaje de los estudiantes. La muestra estuvo constituida por 109 estudiantes. Se realizaron pruebas estadísticas y ...

  5. Federica: the italian way to open educational resources

    Directory of Open Access Journals (Sweden)

    Rosanna De Rosa

    2011-08-01

    Full Text Available Le università stanno recuperando terreno sul piano dell’innovazione tecnologica e didattica. Esse hanno iniziato ad offrire servizi a valore aggiunto, di alta formazione e di professionalizzazione, destinati a rispondere ad una domanda di formazione continua che proviene dalla società e dal mercato. Partendo da una panoramica sulle risorse educative aperte (Open Educational Resources-OER, questo articolo presenta l’esperienza italiana di “Federica”, la piattaforma web learning dell’Università di Napoli Federico II, un progetto open access nato nell’ambito di una università pubblica del Mezzogiorno che intende promuovere una nuova cultura, una cultura-ponte fra la printing literacy e la digital culture. Attraverso un’analisi delle potenzialità dell’open education e dei fattori di successo dell’esperienza “Federica”, l’articolo spiega i limiti e le opportunità che questa strada traccia per le università.

  6. How Should SOF Be Organized?

    Science.gov (United States)

    2011-06-01

    186 Eric Micheletti, French Special Forces: Special Operations Command (Paris: Histoire & Collections, 1999), 16. 187 NSCC, NATO SOF...University, September 2008. Micheletti, Eric. French Special Forces: Special Operations Command. Paris: Histoire & Collections, 1999. Millet, Allan

  7. The future of olive plantation systems on sloping and mountainous land; scenarios for production and natural resource conservation, First Annual Report. EU project Olivero:

    NARCIS (Netherlands)

    Fleskens, L.; Stroosnijder, L.; Graaff, de J.

    2004-01-01

    The project will devote itself to the future of olive plantation systems on sloping and mountainous land in southern Europe. These systems have been affected by emigration of local populations and fierce competition from low land plantations and from non-EU countries, and are currently neither

  8. New holographic scalar field models of dark energy in non-flat universe

    Energy Technology Data Exchange (ETDEWEB)

    Karami, K., E-mail: KKarami@uok.ac.i [Department of Physics, University of Kurdistan, Pasdaran St., Sanandaj (Iran, Islamic Republic of); Research Institute for Astronomy and Astrophysics of Maragha (RIAAM), Maragha (Iran, Islamic Republic of); Fehri, J. [Department of Physics, University of Kurdistan, Pasdaran St., Sanandaj (Iran, Islamic Republic of)

    2010-02-08

    Motivated by the work of Granda and Oliveros [L.N. Granda, A. Oliveros, Phys. Lett. B 671 (2009) 199], we generalize their work to the non-flat case. We study the correspondence between the quintessence, tachyon, K-essence and dilaton scalar field models with the new holographic dark energy model in the non-flat FRW universe. We reconstruct the potentials and the dynamics for these scalar field models, which describe accelerated expansion of the universe. In the limiting case of a flat universe, i.e. k=0, all results given in [L.N. Granda, A. Oliveros, Phys. Lett. B 671 (2009) 199] are obtained.

  9. New holographic scalar field models of dark energy in non-flat universe

    International Nuclear Information System (INIS)

    Karami, K.; Fehri, J.

    2010-01-01

    Motivated by the work of Granda and Oliveros [L.N. Granda, A. Oliveros, Phys. Lett. B 671 (2009) 199], we generalize their work to the non-flat case. We study the correspondence between the quintessence, tachyon, K-essence and dilaton scalar field models with the new holographic dark energy model in the non-flat FRW universe. We reconstruct the potentials and the dynamics for these scalar field models, which describe accelerated expansion of the universe. In the limiting case of a flat universe, i.e. k=0, all results given in [L.N. Granda, A. Oliveros, Phys. Lett. B 671 (2009) 199] are obtained.

  10. Reference: 712 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available t cell Delledonne Massimo|Dietz Karl-Josef|Finkemeier Iris|Jones Alex M E|Laxa Miriam|Mattè Alessandro|Perazzolli Michele|Romero-Puertas Maria C|Vandelle Elodie|Zaninotto Federica

  11. Riigipööre nurjas teise riigipöörde? / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2009-01-01

    Hondurases valitseb juba neljandat päeva sõjaväe toel võimule tulnud ajutine riigipea Roberto Micheletti. Ameerika Ühendriigid ja ÜRO nõuavad kukutatud presidenti José Manuel Zelaya Rosales'i võimule ennistamist

  12. Science Education in a Secular Age

    Science.gov (United States)

    Long, David E.

    2013-01-01

    A college science education instructor tells his students he rejects evolution. What should we think? The scene unfolds in one of the largest urban centers in the world. If we are surprised, why? Expanding on Federica Raia's (2012) first-hand experience with this scenario, I broaden her discussion by considering the complexity of science education…

  13. Learning at the "Boundaries": Radical Listening, Creationism, and Learning from the "Other"

    Science.gov (United States)

    Alexakos, Konstantinos; Pierwola, Agnieszka

    2013-01-01

    In our forum contribution to Federica Raia's manuscript (2012) on learning at the boundaries, we propose that using radical listening in the science education classroom, especially when contentious issues such as evolution are discussed, helps stakeholders learn from each other's values and viewpoints and contributes to bridging divides.

  14. Effects of Minthostachys mollis essential oil and volatiles on seedlings of lettuce, tomato, cucumbre and Bidens pilosa.

    OpenAIRE

    Alonso Amelot, Miguel; Usubillaga, Alfredo; Avila Nuñez, Jorge Luis; Oliveros Bastidas, Alberto; Avendaño Meza, Marisabel

    2007-01-01

    Effects of Minthostachys mollis essential oil and volatiles on seedlings of lettuce, tomato, cucumbre and Bidens pilosa. (Alonso Amelot, Miguel; Usubillaga, Alfredo; Avila Nuñez, Jorge Luis; Oliveros Bastidas, Alberto y Avendaño Meza, Mairsabel) Abstract The extraction and chemical composition of essential oil of Minthostachys mollis (Kunth) Griseb (Lamiaceae) and its inhibitory effects on germation and shoot/root elongation of lettuce, tomato, cucumber and Bidens pilosa (L...

  15. Chemical and Photochemical Reactivity in Microemulsions and Waterless Microemulsions.

    Science.gov (United States)

    1988-02-10

    virtually the same as that found in the alcohol rich microemulsion A. This value is also close to that found in pure butanol (= 5.0 - table I). It would...formamide or alcohol rich). RESEARCH PATTERN -Supplementing the physical chemical study of the microemulsion medium involving ionic surfactants with density...SAMII (1/02/1988) Ii&N 3 Part II - OXYDATIONS BY HYDROPEROXIDES IN MICROEMULSIONS E. OLIVEROS and M.T. MAURETTE During the past six months, the financial

  16. Memoria y olvido de una ministra anarquista

    Directory of Open Access Journals (Sweden)

    Ángel Herrerín López

    1998-01-01

    Full Text Available Este artículo analiza como la imagen histórica de Federica Montseny ha ido variando con el paso del tiempo. Para dicho análisis se utiliza una doble óptica: por un lado, la visión que nos aportan, a través de sus memorias, sus compañeros libertarios; y por otro, como es tratada, esa imagen, por la empresa publicista.This article analyses Federica Montseny's historical image which has changed throughout time. A double point of view is used to do it: On one, hand the visión that her anarchist colleagues provide thorugh their memories, and on the other hand, we can see the way that her image has been treated by the standard press.

  17. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control

    OpenAIRE

    Di Pierro, Francesco; Villanova,Nicola; Agostini,Federica; Soverini,Valentina; Marchesini,Giulio; Marzocchi,Rebecca

    2012-01-01

    Francesco Di Pierro,1 Nicola Villanova,2 Federica Agostini,2 Rebecca Marzocchi,2 Valentina Soverini,2 Giulio Marchesini21Scientific Department, Velleja Research, Milano, 2Diseases of Metabolism, S Orsola Malpighi Hospital, Bologna, ItalyBackground: Suboptimal glycemic control is a common situation in diabetes, regardless of the wide range of drugs available to reach glycemic targets. Basic research in diabetes is endeavoring to identify new actives working as insulin savers, use of which coul...

  18. Dimensional assessment of DSM-5 social anxiety symptoms among university students and its relationship with functional impairment

    OpenAIRE

    Dell’Osso, Liliana; Abelli, Marianna; Pini, Stefano; Carlini, Marina; Carpita, Barbara; Macchi, Elisabetta; Gorrasi, Federica; Mengali, Francesco; Tognetti, Rosalba; Massimetti, Gabriele

    2014-01-01

    Liliana Dell’Osso,1 Marianna Abelli,1 Stefano Pini,1 Marina Carlini,1 Barbara Carpita,1 Elisabetta Macchi,2 Federica Gorrasi,2 Francesco Mengali,1 Rosalba Tognetti,2 Gabriele Massimetti1 1Department of Clinical and Experimental Medicine, Section of Psychiatry, 2Prorectorate to Students Affairs and Right to Education, University of Pisa, Pisa, Italy Abstract: Social anxiety disorder is a common condition often associated with severe impairment in educational career. The aim of this...

  19. Correction to: Impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in Northern Italy.

    Science.gov (United States)

    Giacobbe, Daniele Roberto; Del Bono, Valerio; Mikulska, Malgorzata; Gustinetti, Giulia; Marchese, Anna; Mina, Federica; Signori, Alessio; Orsi, Andrea; Rudello, Fulvio; Alicino, Cristiano; Bonalumi, Beatrice; Morando, Alessandra; Icardi, Giancarlo; Beltramini, Sabrina; Viscoli, Claudio

    2017-12-01

    A technical error led to incorrect rendering of the author group in this article. The correct authorship is as follows: Daniele Roberto Giacobbe 1 , Valerio Del Bono 1 , Malgorzata Mikulska 1 , Giulia Gustinetti 1 , Anna Marchese 2 , Federica Mina 3 , Alessio Signori 4 , Andrea Orsi 5 , Fulvio Rudello 6 , Cristiano Alicino 5 , Beatrice Bonalumi 3 , Alessandra Morando 7 , Giancarlo Icardi 5 , Sabrina Beltramini 3 , Claudio Viscoli 1 ; On behalf of the San Martino Antimicrobial Stewardship Group.

  20. High performance of low cost soft magnetic materials

    Indian Academy of Sciences (India)

    Author Affiliations. Josefina M Silveyra1 Emília Illeková2 Marco Coïsson3 Federica Celegato3 Franco Vinai3 Paola Tiberto3 Javier A Moya1 Victoria J Cremaschi1. Lab. de Sólidos Amorfos, INTECIN, FIUBA-CONICET, Paseo Colón 850, (C1063ACV) Buenos Aires, Argentina; Institute of Physics SAS, Dúbravská cesta 9, 845 ...

  1. Discrete geometry in honor of W. Kuperberg's 60th birthday

    CERN Document Server

    Bezdek, Andras

    2003-01-01

    Transversal lines to lines and intervals, Jorge L. Arocha, Javier Bracho, and Luis Montejano; on a shortest path problem of G. Fejes, Toth Donald R. Baggett and Andras Bezdek; a short survey of (r,q)-structures, Vojtech Balint; lattice points on the boundary of the integer hull, Imre Barany and Karoly Boroczky, Jr; the Erdos-Szekeres problem for planar points in arbitrary position, Tibor Bisztriczky and Gabor Fejes Toth, separation in totally-sewn 4-polytopes, Tibor Bisztriczky and Deborah Oliveros, on a class of equifacetted polytopes, Gerd Blind and Roswitha Blind; chessboard Ramsey numbers,

  2. Impact of EMS Outreach: Successful Developments in Latin America

    Science.gov (United States)

    Olivero, Ofelia A.; Larramendy, Marcelo; Soloneski, Sonia; Menck, Carlos F.M.; Matta, Jaime; Folle, Gustavo A.; Zamorano-Ponce, Enrique; Spivak, Graciela

    2014-01-01

    This collection of articles was inspired by the long-standing relationship between the Environmental Mutagen Society and Latin American scientists, and by the program for the 39th Environmental Mutagen Society meeting in Puerto Rico in 2008, which included a symposium featuring “South of the border” scientists. This collection, compiled by Graciela Spivak and Ofelia Olivero, both originally from Argentina, highlights scientists who work in or were trained in Latin American countries and in Puerto Rico in a variety of scientific specialties related to DNA repair and cancer susceptibility, genomic organization and stability, genetic diversity, and environmental contaminants. PMID:20213840

  3. The Role of Novel Substituted Diindolyl Methane Analogues in the Treatment of Triple Negative and ErbB2 Positive Breast Cancer

    Science.gov (United States)

    2017-07-01

    0.34, 4.35 ± 0.48 and 5.61 ± 0.30 mm, respectively. All three cell lines showed more potency toward GA and GAL with little variations between their...such variation could be the passage number of injected MDA-MB- 231 cells. We have injected the cells which were freshly cultivated from tumor tissue...anticancer drugs berberine and betulinic acid, PLoS ONE 9 (3) (2014) e89919. [11] A.A. Goldberg , H. Draz, D. Montes-Grajales, J. Olivero-Verbel, S.H. Safe

  4. Trigeminal neuralgia: successful antiepileptic drug combination therapy in three refractory cases

    Directory of Open Access Journals (Sweden)

    Prisco L

    2011-08-01

    Full Text Available Lara Prisco1, Mario Ganau2, Federica Bigotto1, Francesca Zornada11Department of Anaesthesiology, Intensive Care and Emergency Medicine, University Hospital of Cattinara, 2Graduate School of Nanotechnology, University of Trieste, ItalyAbstract: Antiepileptic drug combination therapy remains an empirical second-line treatment approach in trigeminal neuralgia, after treatment with one antiepileptic drug or other nonantiepileptic drugs have failed. The results in three patients followed in our clinic are not sufficient to draw definitive conclusions, but suggest the possibility of developing this type of therapeutic approach further.Keywords: trigeminal neuralgia, antiepileptic drugs, combination therapy

  5. Kes teevad ülikooli keelekeskuse rahvusvaheliseks? Saage tuttavaks!

    Index Scriptorium Estoniae

    2006-01-01

    Küsimustele "Mida Eestis oma keelt õpetades raskeimaks peate?" ja "Mis teid Eestis kõige rohkem üllatas?" vastavad Tartu Ülikooli keelekeskuse läti keele lektor Ilze Zagorska, itaalia keele lektor Federica Bossi, prantsuse keele lektor Charlène Manil, korea keele lektor Jinseok Seo, jaapani keele lektor Eri Miyano, ukraina keele lektor Ljudmilla Dulitšenko, hispaania keele lektor Manuel Neftalí Peral Joris, inglise keele lektor Casey Collins ja türgi keele lektor Hagani Gayibli

  6. Contacto Pele a Pele

    OpenAIRE

    Carvalho, Ana; Zangão, Otília

    2014-01-01

    Introdução: Uma das formas de promover o aleitamento materno consiste em permitir o contacto pele com pele entre a mãe e o bebé após o nascimento. O contacto pele-a- pele ajuda o recém-nascido na transição para a vida extra uterina, na manutenção da temperatura, no processo de vinculação, no início e manutenção prolongada da amamentação, na adaptação ao meio ambiente não estéril e na diminuição da dor, do stress e do choro (Sobel, Silvestre,Mantaring,Oliveros & Nyunt-U, 2011; WABA, 2007).Obje...

  7. A more general interacting model of holographic dark energy

    International Nuclear Information System (INIS)

    Yu Fei; Zhang Jingfei; Lu Jianbo; Wang Wei; Gui Yuanxing

    2010-01-01

    So far, there have been no theories or observational data that deny the presence of interaction between dark energy and dark matter. We extend naturally the holographic dark energy (HDE) model, proposed by Granda and Oliveros, in which the dark energy density includes not only the square of the Hubble scale, but also the time derivative of the Hubble scale to the case with interaction and the analytic forms for the cosmic parameters are obtained under the specific boundary conditions. The various behaviors concerning the cosmic expansion depend on the introduced numerical parameters which are also constrained. The more general interacting model inherits the features of the previous ones of HDE, keeping the consistency of the theory.

  8. Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

    Directory of Open Access Journals (Sweden)

    Rossi L

    2013-11-01

    Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

  9. Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache

    Directory of Open Access Journals (Sweden)

    Chirchiglia D

    2016-07-01

    Full Text Available Domenico Chirchiglia,1 Attilio Della Torre,2 Francesco Signorelli,2 Giorgio Volpentesta,2 Giusy Guzzi,2 Carmelino Angelo Stroscio,2 Federica Deodato,2 Donatella Gabriele,2 Angelo Lavano,2 1Department of Neurosurgery, Neurophysiopathology Unit, 2Department of Neurosurgery, University of Catanzaro “Magna Graecia”, Catanzaro, Italy Abstract: Nummular headache has been recently described as a primary disorder characterized by head pain exclusively felt in a small rounded area typically 2–6 cm in diameter, not attributed to another disorder. Both size and shape of the painful area remain constant since the onset of symptoms. A 57-year-old woman presented with a history of focal episodic pain in a circumscribed area on the right parietal region. The administration of standard oral doses of palmitoylethanolamide and topiramate in combination showed an improvement in pain symptoms and on pain measuring scales. Keywords: algometry, migraine, nummular headache, palmitoylethanolamide, topiramate

  10. Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas

    Directory of Open Access Journals (Sweden)

    De Vita A

    2016-10-01

    Full Text Available Alessandro De Vita,1 Laura Mercatali,1 Federica Recine,1 Federica Pieri,2 Nada Riva,1 Alberto Bongiovanni,1 Chiara Liverani,1 Chiara Spadazzi,1 Giacomo Miserocchi,1 Dino Amadori,1 Toni Ibrahim1 1Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST IRCCS, Meldola, FC, 2Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy Abstract: Sarcomas are a heterogeneous group of mesenchymal tumors arising from soft tissue or bone, with an uncertain etiology and difficult classification. Soft tissue sarcomas (STSs account for around 1% of all adult cancers. Till date, more than 50 histologic subtypes have been identified. Adipocyte sarcoma or liposarcoma (LPS is one of the most common STS subtypes, accounting for 15% of all sarcomas, with an incidence of 24% of all extremity STSs and 45% of all retroperitoneal STSs. The new World Health Organization classification system has divided LPS into four different subgroups: atypical lipomatous tumor/well-differentiated LPS, dedifferentiated LPS, myxoid LPS, and pleomorphic LPS. These lesions can develop at any location and exhibit different aggressive potentials reflecting their morphologic diversity and clinical behavior. Patients affected by LPS should be managed in specialized multidisciplinary cancer centers. Whereas surgical resection is the mainstay of treatment for localized disease, the benefits of adjuvant and neoadjuvant chemotherapy are still unclear. Systemic treatment, particularly chemotherapy, is still limited in metastatic disease. Despite the efforts toward a better understanding of the biology of LPS, the outcome of advanced and metastatic patients remains poor. The advent of targeted therapies may lead to an improvement of treatment options and clinical outcomes. A larger patient enrollment into translational and clinical studies will help increase the knowledge of the biological behavior of LPSs, test new drugs, and introduce new

  11. Metodología para el Escalamiento de Agitadores Mecánicos Utilizados en Procesos con Fluidos No-Newtonianos

    Directory of Open Access Journals (Sweden)

    Oliveros T. Carlos E.

    1997-06-01

    Full Text Available Se determinó experimentalmente la tasa promedia de cortante (TCP generada por dos rotores utilizados para el desmucilaginado mecánico del café en Colombia: El CENICAFE III y El COLMECANO. Los valores experimentales de TCP fueron comparados con datos estimados con un modelo teórico obtenido asumiendo que el campo de flujo generado por el rotor se asemeja al flujo tipo Couette (TCP y un modelo propuesto por Oliveros (1993,1995. Se utilizó la prueba de X^2 (con 5% de significancia para comparar los valores experimentales y teóricos y se observó que hay diferencias entre ellos. A partir del modelo TCP se obtuvo una expresión semiteórica para estimar la TCP generada por el rotor COLMECANO con alta con fiabilidad (r^2 = 0.982. A una misma velocidad de rotación el agitador COLMECANO genera mayores valores de TCP que el rotor CENICAFE 1/1. luego debe generar mayores tasas de desmucilaginado. La potencia requerida para agitar suspensiones de café en baba-mucílago+agua adicionada (1 L/kg de cps. en el rango de 300 a l. 200 rpm, utilizando los rotores CENICAFE III y COLMECANO, fué medida experimentalmente y estimada teóricamente con dos modelos: el modelo propuesto por Oliveros (1993.1995 Y un modelo obtenido asumiendo que el campo de flujo generado por los rotores es del tipo Couette (modelo pc. Los valores experimentales y estimados fueron comparados por medio de la prueba de X^2 (al 5% de significancia observándose diferencias entre ellos. Mediante un análisis de regresión lineal simple aplicado a los valores obtenidos con el modelo pe se obtuvo una expresión semi-teórica la cual permite estimar con alta confiabilidad la potencia para agitar las suspensiones de café en baba-mucílago+agua (r^2 = 0,982 con el rotor COLMECANO. A una misma velocidad de rotación, el rotor COLMECANO requiere menos potencia que el CENICAFE III para agitar suspensiones de café en baba-mucílago+agua (1 litro de agua/kg de cps. Se utilizó el concepto

  12. Susceptibilidad a endosulfan y monitoreo de resistencia en poblaciones de Piezodorus guildinii (Insecta, Heteroptera: Pentatomidae, en cultivos de soja de Argentina Susceptibility to endosulphan and resistance monitoring in «green stinkbug» populations, Piezodorus guildinii (Insecta, Heteroptera: Pentatomidae, in soya crops in Argentina

    Directory of Open Access Journals (Sweden)

    Teodoro Stadler

    2006-12-01

    Full Text Available Se determinó la susceptibilidad a endosulfan en diferentes poblaciones de P. guildinii (Westwood, que afectan los cultivos de soja en las provincias argentinas de Santiago del Estero, Chaco y Santa Fe. Se estableció su estatus de susceptibilidad actual para todas las poblaciones estudiadas, y se monitoreó la resistencia a endosulfan en una población de P. guildinii , de Santiago del Estero desde 2002 a 2005, para detectar los cambios en la respuesta al insecticida, con la finalidad de alertar acerca de posibles fallas de control. Los insectos fueron colectados en plantaciones de soja en las localidades de Oliveros, Reconquista, San Justo, Bandera y Coronel Du Graty. Los bioensayos se desarrollaron en laboratorio por el método del tópico, en el marco de los protocolos de la Organización Mundial de la Salud. El estatus de susceptibilidad actual a endosulfan, en las poblaciones de P. guildinii estudiadas fue de: DL95 = 0,680μg/μL [0,489-1,338] a 2,277μg/μL [1,526-5,418]. De los resultados de los bioensayos se desprende que las poblaciones estudiadas, muy distantes geográficamente unas de otras, muestran algunas diferencias en su tolerancia a endosulfan (capacidad de detoxificación, exhibiendo, además, un incremento gradual de la misma desde la zona sur de Sta. Fe (Oliveros hacia el norte (Bandera - Chaco, que probablemente se relaciona con los factores ambientales propios de cada región, y se pueden deber también a procesos toxicodínámicos o toxicocinéticos. La población de P. guildinii de Coronel Du Graty (Santiago del Estero monitoreada desde 2002 a 2005, no mostró un incremento de tolerancia al endosulfan a lo largo del tiempo, que sugiera la presencia de fenómenos de resistencia. Factores poblacionales y ambientales son corresponsables de las variaciones temporales y espaciales de la susceptibilidad de una población a un biocida, esto hace que los límites entre la plasticidad fenotípica y las diferencias en la

  13. ELECTRICAL CONDUCTIVITY OF SOYBEAN SEED CULTIVARS AND ADJUSTED MODELS OF LEAKAGE CURVES ALONG THE TIME

    Directory of Open Access Journals (Sweden)

    ADRIANA RITA SALINAS

    2010-01-01

    Full Text Available The objective of this work was to study the behavior of ten soybean [Glycine max (L. Merr.] cultivars using the electrical conductivity (EC test by the comparison of curves of the accumulative electrolyte leakage along the time and to establish the statistical model that allow the best adjust of the curves. Ten soybean cultivars were used and they were mechanically harvested in 2004 in the EEA Oliveros, Santa Fe, Argentina. Measurements of EC were made for 100 individual seeds of each cultivar during 20 hours of immersion at intervals of 1 hour using an equipment that permit an individual seed analysis (Seed Automatic Analyzer SAD 9000S. There were proposed two statistical models to study the EC along the time of the 10 cultivars studied using SAS Statistics Program, to select the model that better allow us to understand the EC behavior along the time. Model 1 allowed to make comparisons of EC along the time between cultivars and to study the influence of the production environment on the physiological quality of soybean seeds. The time to reach the stabilization of the EC must not be lower than 19 hours for the different cultivars.

  14. Dimensional assessment of DSM-5 social anxiety symptoms among university students and its relationship with functional impairment

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    Dell’Osso L

    2014-07-01

    Full Text Available Liliana Dell’Osso,1 Marianna Abelli,1 Stefano Pini,1 Marina Carlini,1 Barbara Carpita,1 Elisabetta Macchi,2 Federica Gorrasi,2 Francesco Mengali,1 Rosalba Tognetti,2 Gabriele Massimetti1 1Department of Clinical and Experimental Medicine, Section of Psychiatry, 2Prorectorate to Students Affairs and Right to Education, University of Pisa, Pisa, Italy Abstract: Social anxiety disorder is a common condition often associated with severe impairment in educational career. The aim of this paper was to evaluate prevalence rates and correlates of mild, moderate, and severe forms of social anxiety spectrum in a large sample of university students. Overall, 717 university students were assessed with the Social Anxiety Spectrum Self-Report questionnaire. Using two cut-off scores, 61.4% of subjects were classified as low scorers, 10% as medium scorers, and 28.6% as high scorers. Both high and medium scorers reported fears related to social situations. Interpersonal sensitivity and specific phobias were more common among women with low scores. Childhood/adolescence social anxiety features were more common among males with medium scores. Behavioral inhibition was more common among males with high scores. Functional impairment was severe among high scorers and, to a lesser extent, among medium scorers. Social anxiety spectrum is largely represented among university students. Future studies should investigate whether sufferers of social phobia underachieve or end their professional objectives prematurely. Keywords: social anxiety spectrum, behavioral inhibition, gender, subthreshold, self-rating, DSM-5

  15. Quasielastic neutron scattering in biology: Theory and applications.

    Science.gov (United States)

    Vural, Derya; Hu, Xiaohu; Lindner, Benjamin; Jain, Nitin; Miao, Yinglong; Cheng, Xiaolin; Liu, Zhuo; Hong, Liang; Smith, Jeremy C

    2017-01-01

    Neutrons scatter quasielastically from stochastic, diffusive processes, such as overdamped vibrations, localized diffusion and transitions between energy minima. In biological systems, such as proteins and membranes, these relaxation processes are of considerable physical interest. We review here recent methodological advances and applications of quasielastic neutron scattering (QENS) in biology, concentrating on the role of molecular dynamics simulation in generating data with which neutron profiles can be unambiguously interpreted. We examine the use of massively-parallel computers in calculating scattering functions, and the application of Markov state modeling. The decomposition of MD-derived neutron dynamic susceptibilities is described, and the use of this in combination with NMR spectroscopy. We discuss dynamics at very long times, including approximations to the infinite time mean-square displacement and nonequilibrium aspects of single-protein dynamics. Finally, we examine how neutron scattering and MD can be combined to provide information on lipid nanodomains. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. New generation non-stationary portable neutron generators for biophysical applications of Neutron Activation Analysis.

    Science.gov (United States)

    Marchese, N; Cannuli, A; Caccamo, M T; Pace, C

    2017-01-01

    Neutron sources are increasingly employed in a wide range of research fields. For some specific purposes an alternative to existing large-scale neutron scattering facilities, can be offered by the new generation of portable neutron devices. This review reports an overview for such recently available neutron generators mainly addressed to biophysics applications with specific reference to portable non-stationary neutron generators applied in Neutron Activation Analysis (NAA). The review reports a description of a typical portable neutron generator set-up addressed to biophysics applications. New generation portable neutron devices, for some specific applications, can constitute an alternative to existing large-scale neutron scattering facilities. Deuterium-Deuterium pulsed neutron sources able to generate 2.5MeV neutrons, with a neutron yield of 1.0×10 6 n/s, a pulse rate of 250Hz to 20kHz and a duty factor varying from 5% to 100%, when combined with solid-state photon detectors, show that this kind of compact devices allow rapid and user-friendly elemental analysis. "This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo". Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Colloquia on High Energy Physics: IFAE 2012

    International Nuclear Information System (INIS)

    Barion, L.; Bozzi, C.; Fioravanti, E.; Pagliara, G; Ricci, B.

    2013-01-01

    The 2012 edition of the 'Incontri di Fisica delle Alte Energie' (IFAE2012) was held at the Aula Magna del Rettorato of the Ferrara University from April 11th to 13th. The Conference was attended by more than 150 participants, with about 75 presentations and 35 posters covering the most recent advances in High Energy Physics, Astroparticle and Neutrino Physics, Heavy Ions and Detection Techniques. Only plenary sessions were held, giving young researchers the opportunity to present their work to a large audience, either with talks or posters, which were on permanent display during the entire conference. The scientific program was organized in 7 sessions: 1-Standard Model and beyond; 2-QCD; 3-Heavy Flavour; 4-Heavy Ions; 5-Astro particles; 6-Neutrino Physics; 7-New Technologies. Introductory, state-of-the art talks, opened the Conference and each session. More detailed talks followed, stimulating lively discussions and interactions between the speakers and the participants. Three talks and two posters by young researchers (Matteo Biassoni, Roberta Cardinale, Stefano Perazzini, Federica Primavera and Laura Zotti) were selected for their high quality and awarded a prize money. It would not have been possible to held this conference without the support of INFN Sezione di Ferrara, Universita' di Ferrara and the generous contributions of Hamamatsu, Caen, National Instruments and AdvanSiD, whom we gratefully acknowledge.

  18. L’educatore sociale fra i Servizi e l’intervento di strada.

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    Chiara Giustini

    2007-07-01

    Full Text Available Ci siamo sempre poste molte domande sulla povertà, sulle cause dell'impoverimento, sulle responsabilità di noi “ricchi”, sulle possibilità che ogni persona ha di cambiare le cose. Forse è per questo che tre anni fa abbiamo deciso di aderire alla proposta del prof. Genovese e di partecipare al progetto "Un sacco a pelo per l'inverno" promosso dalla Caritas Diocesana di Bologna: da questa collaborazione è nato il Gruppo Nuove Povertà, tuttora impegnato in attività di ricerca sulla povertà, di impegno concreto e di sensibilizzazione al tema della marginalità nella nostra città e di formazione per gli studenti della Facoltà di Scienze della Formazione. Forse è sempre per questo che per le nostre tesi abbiamo affrontato il problema della povertà e delle nuove povertà, la condizione dei senza dimora e le risposte dei Servizi. Ne sono nati due articoli: il primo, firmato da Federica Filippini, affronta il tema della povertà nella sua multidimensionalità e analizza in particolare la condizione dei senza dimora, il percorso di impoverimento, le difficoltà della vita in strada, il rapporto con la città e i Servizi; il secondo, firmato da Chiara Giustini, si sofferma, invece, sulla figura dell'educatore, sia all'interno dei Servizi rivolti ai senza dimora, sia nel lavoro di strada.

  19. Emission of Polychlorinated Naphthalenes during Thermal Related Processes

    Science.gov (United States)

    Liu, Guorui; Zheng, Minghui; Du, Bing; Liu, Wenbin; Zhang, Bing; Xiao, Ke

    2010-05-01

    Due to the structural similarity of polychlorinated naphthalenes (PCNs) to those of dioxins, PCNs exhibit toxicological properties similar to dioxins (Olivero-Verbel et al., 2004). Based on their high toxicity, persistence, bioaccumulation, and long-distance transmission, PCNs were also selected as a candidate POP for the UN-ECE (United Nations Economic Commission for Europe) POP protocol (Lerche et al., 2002). In addition, some studies suggested that PCNs contributed a greater proportion of the dioxin-like activity than polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) contributed in some locations (Kannan et al., 1998). However, the identification and quantitation for PCN sources are very scarce compared with PCDD/Fs. Understanding the emission levels and developing the emission inventory of PCNs is important for regulatory and source reduction purposes. In this study, several potential sources were preliminarily investigated for PCN release. Coking process (CP), iron ore sintering (IOS), and electric arc furnace steel making units (AF) were selected due to their huge activity level of industrial production in China. Municipal solid waste incineration (MSWI) and medical waste incineration (MWI) were also investigated because of the possible high concentration of PCNs in stack gas. Two plants were investigated for each thermal related process, except for MWI with one incinerator was investigated. The stack gas samples were collected by automatic isokinetic sampling system (Isostack Basic, TCR TECORA, Milan Italy). Isotope dilution high resolution gas chromatography coupled with high resolution mass spectrometry (HRGC/HRMS) technique was used for the identification and quantitation of PCN congeners. The concentrations of PCNs from the selected thermal processes were determined in this study. The average concentrations of total PCNs were 26 ng Nm-3 for CP, 65 ng Nm-3 for IOS, 720 ng Nm-3 for AF, 443 ng Nm-3 for MSWI, and

  20. Evaluating accuracy of DSSAT model for soybean yield estimation using satellite weather data

    Science.gov (United States)

    Ovando, Gustavo; Sayago, Silvina; Bocco, Mónica

    2018-04-01

    Crop models allow simulating the development and yield of the crops, to represent and to evaluate the influence of multiple factors. The DSSAT cropping system model is one of the most widely used and contains CROPGRO module for soybean. This crop has a great importance for many southern countries of Latin America and for Argentina. Solar radiation and rainfall are necessary variables as inputs for crop models; however these data are not as readily available. The satellital products from Clouds and Earth's Radiant Energy System (CERES) and Tropic Rainfall Measurement Mission (TRMM) provide continuous spatial and temporal information of solar radiation and precipitation, respectively. This study evaluates and quantifies the uncertainty in estimating soybean yield using a DSSAT model, when recorded weather data are replaced with CERES and TRMM ones. Different percentages of data replacements, soybean maturity groups and planting dates are considered, for 2006-2016 period in Oliveros (Argentina). Results show that CERES and TRMM products can be used for soybean yield estimation with DSSAT considering that: percentage of data replacement, campaign, planting date and maturity group, determine the amounts and trends of yield errors. Replacements with CERES data up to 30% result in %RMSE lower than 10% in 87% of the cases; while the replacement with TRMM data presents the best statisticals in campaigns with high yields. Simulations based entirely on CERES solar radiation give better results than those with TRMM. In general, similar percentages of replacement show better performance in the estimation of soybean yield for solar radiation than the replacement of precipitation values.

  1. Parámetros químicos y biológicos como indicadores de calidad del suelo en diferentes manejos Chemical and biological parameters as indicators of soil quality under different managements

    Directory of Open Access Journals (Sweden)

    Laura Ferreras

    2009-06-01

    Full Text Available El objetivo del trabajo fue evaluar la sensibilidad de una serie de parámetros químicos y bioquímicos en suelos representativos de la Región Pampeana bajo diferentes manejos con la finalidad de: i establecer los parámetros que reflejen de manera más sensible y tempranamente el grado de degradación o recuperación; ii comparar la información generada de las parcelas bajo cultivo con el mismo tipo de suelo no perturbado, considerado como referencia (T. En ensayos con diferentes manejos localizados en las EEA INTA Oliveros, Marcos Juárez y Rafaela se evaluó: Carbono orgánico total (COT, carbono asociado a la fracción fina (COff, carbono asociado a la fracción gruesa (COfg, carbono de la biomasa microbiana (CBM, actividad respiratoria microbiana (ARM y actividad de las enzimas fosfatasa ácida (Pasa, deshidrogenasa (Dasa y ureasa (Uasa. Se calculó el cociente metabólico microbiano (qCO2, a través de la relación entre ARM y el CBM, como así también las relaciones entre actividades de las enzimas y CBM en función del COT. Para cada sitio, el suelo bajo cultivo presentó en la mayoría de las variables analizadas valores inferiores con respecto a T (pThe aim of the work was to assess the sensitivity of chemical and biochemical parameters in representative soils of the Pampa Region under different managements with the purpose of i establishing the soil parameters that may have a role as early and sensitive indicators of soil ecological stress and restoration; and ii comparing the results from cropped plots with the same undisturbed soil type, considered as reference (T. The experiment was carried out on experimental plots under different soil managements at the INTA Experimental Stations at Oliveros, Marcos Juárez and Rafaela. Total organic carbon (COT, organic carbon associated with the fine fraction (COff and organic carbon associated with the coarse fraction (COfg, microbial biomass carbon (CBM, soil microbial respiration (ARM

  2. Using containerless methods to develop amorphous pharmaceuticals.

    Science.gov (United States)

    Weber, J K R; Benmore, C J; Suthar, K J; Tamalonis, A J; Alderman, O L G; Sendelbach, S; Kondev, V; Yarger, J; Rey, C A; Byrn, S R

    2017-01-01

    bioavailability. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Combination of acoustic levitation with small angle scattering techniques and synchrotron radiation circular dichroism. Application to the study of protein solutions.

    Science.gov (United States)

    Cristiglio, Viviana; Grillo, Isabelle; Fomina, Margarita; Wien, Frank; Shalaev, Evgenyi; Novikov, Alexey; Brassamin, Séverine; Réfrégiers, Matthieu; Pérez, Javier; Hennet, Louis

    2017-01-01

    The acoustic levitation technique is a useful sample handling method for small solid and liquids samples, suspended in air by means of an ultrasonic field. This method was previously used at synchrotron sources for studying pharmaceutical liquids and protein solutions using x-ray diffraction and small angle x-ray scattering (SAXS). In this work we combined for the first time this containerless method with small angle neutron scattering (SANS) and synchrotron radiation circular dichroism (SRCD) to study the structural behavior of proteins in solutions during the water evaporation. SANS results are also compared with SAXS experiments. The aggregation behavior of 45μl droplets of lysozyme protein diluted in water was followed during the continuous increase of the sample concentration by evaporating the solvent. The evaporation kinetics was followed at different drying stage by SANS and SAXS with a good data quality. In a prospective work using SRCD, we also studied the evolution of the secondary structure of the myoglobin protein in water solution in the same evaporation conditions. Acoustic levitation was applied for the first time with SANS and the high performances of the used neutron instruments made it possible to monitor fast container-less reactions in situ. A preliminary work using SRCD shows the potentiality of its combination with acoustic levitation for studying the evolution of the protein structure with time. This multi-techniques approach could give novel insights into crystallization and self-assembly phenomena of biological compound with promising potential applications in pharmaceutical, food and cosmetics industry. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control

    Directory of Open Access Journals (Sweden)

    Di Pierro F

    2012-07-01

    Full Text Available Francesco Di Pierro,1 Nicola Villanova,2 Federica Agostini,2 Rebecca Marzocchi,2 Valentina Soverini,2 Giulio Marchesini21Scientific Department, Velleja Research, Milano, 2Diseases of Metabolism, S Orsola Malpighi Hospital, Bologna, ItalyBackground: Suboptimal glycemic control is a common situation in diabetes, regardless of the wide range of drugs available to reach glycemic targets. Basic research in diabetes is endeavoring to identify new actives working as insulin savers, use of which could delay the introduction of injectable insulin or reduce the insulin dose needed. Commonly available as a nutraceutical, berberine is a potential candidate.Methods and results: Because its low oral bioavailability can be overcome by P-glycoprotein inhibitors like herbal polyphenols, we have tested the nutraceutical combination of Berberis aristata extract and Silybum marianum extract (Berberol® in type 2 diabetes in terms of its additive effect when combined with a conventional oral regimen for patients with suboptimal glycemic control. After 90 days of treatment, the nutraceutical association had a positive effect on glycemic and lipid parameters, significantly reducing glycosylated hemoglobin, basal insulin, homeostatic model assessment of insulin resistance, total and low-density lipoprotein cholesterol, and triglycerides. A relevant effect was also observed in terms of liver function by measuring aspartate transaminase and alanine transaminase. The product had a good safety profile, with distinctive gastrointestinal side effects likely due to its acarbose-like action.Conclusion: Although further studies should be carried out to confirm our data, Berberol could be considered a good candidate as an adjunctive treatment option in diabetes, especially in patients with suboptimal glycemic control.Keywords: berberine, silymarin, glycosylated hemoglobin, diabetes

  5. Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

    Directory of Open Access Journals (Sweden)

    Buggio L

    2017-05-01

    Full Text Available Laura Buggio,1,2 Giussy Barbara,3 Federica Facchin,4 Maria Pina Frattaruolo,1,2 Giorgio Aimi,2 Nicola Berlanda2 1Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 2Departmental Operating Unit of Surgical Gynecology and Endometriosis, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, 3Department of Obstetrics and Gynecology and Service for Sexual and Domestic Violence (SVSeD, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, 4Faculty of Psychology, Catholic University of Milan, Milan, Italy Abstract: Endometriosis has a multifactorial etiology. The onset and progression of the disease are believed to be related to different pathogenic mechanisms. Among them, the environment and lifestyle may play significant roles. Diet, dietary supplements, physical exercise, osteopathy, massage, acupuncture, transcutaneous electrical nerve stimulation, and Chinese herbal medicine may represent a complementary and feasible approach in the treatment of symptoms related to the disease. In this narrative review, we aimed to examine the most updated evidence on these alternative approaches implicated in the self-management of the disease. In addition, several studies have demonstrated that endometriosis may negatively impact mental health and quality of life, suggesting that affected women may have an increased risk of developing psychological suffering as well as sexual problems due to the presence of pain. In light of these findings, we discuss the importance of integrating psychological interventions (including psychotherapy and sexual therapy in endometriosis treatment. Keywords: sexual therapy, diet, physical activity, alternative medicine, psychotherapy 

  6. Triple-negative breast cancer: new perspectives for targeted therapies

    Directory of Open Access Journals (Sweden)

    Tomao F

    2015-01-01

    Full Text Available Federica Tomao,1 Anselmo Papa,2 Eleonora Zaccarelli,2 Luigi Rossi,2 Davide Caruso,2 Marina Minozzi,2 Patrizia Vici,3 Luigi Frati,4 Silverio Tomao21Department of Gynecology and Obstetrics, “Sapienza” University of Rome, Policlinico “Umberto I”, Rome, 2Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Oncology Unit, Istituto Chirurgico Ortopedico Traumatologico, Latina, 3Division of Medical Oncology B, Regina Elena National Cancer Institute, Rome, Italy; 4Department of Molecular Medicine, “Sapienza” University of Rome, Policlinico “Umberto I”, Rome, ItalyAbstract: Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors. It has became apparent that this diversity may be justified by distinct patterns of genetic, epigenetic, and transcriptomic aberrations. The identification of gene-expression microarray-based characteristics has led to the identification of at least five breast cancer subgroups: luminal A, luminal B, normal breast-like, human epidermal growth factor receptor 2, and basal-like. Triple-negative breast cancer is a complex disease diagnosed by immunohistochemistry, and it is characterized by malignant cells not expressing estrogen receptors or progesterone receptors at all, and human epidermal growth factor receptor 2. Along with this knowledge, recent data show that triple-negative breast cancer has specific molecular features that could be possible targets for new biological targeted drugs. The aim of this article is to explore the use of new drugs in this particular setting, which is still associated with poor prognosis and high risk of distant recurrence and death.Keywords: basal-like breast cancer, estrogen–progesterone receptors, gene-expression microarray, human epidermal growth factor receptor 2, chemotherapy, target therapy

  7. Water response to ganglioside GM1 surface remodelling.

    Science.gov (United States)

    Brocca, P; Rondelli, V; Mallamace, F; Di Bari, M T; Deriu, A; Lohstroh, W; Del Favero, E; Corti, M; Cantu', L

    2017-01-01

    Gangliosides are biological glycolipids participating in rafts, structural and functional domains of cell membranes. Their headgroups are able to assume different conformations when packed on the surface of an aggregate, more lying or standing. Switching between different conformations is possible, and is a collective event. Switching can be induced, in model systems, by concentration or temperature increase, then possibly involving ganglioside-water interaction. In the present paper, the effect of GM1 ganglioside headgroup conformation on the water structuring and interactions is addressed. Depolarized Rayleigh Scattering, Raman Scattering, Quasielastic Neutron Scattering and NMR measurements were performed on GM1 ganglioside solutions, focusing on solvent properties. All used techniques agree in evidencing differences in the structure and dynamics of solvent water on different time-and-length scales in the presence of either GM1 headgroup conformations. In general, all results indicate that both the structural properties of solvent water and its interactions with the sugar headgroups of GM1 respond to surface remodelling. The extent of this modification is much higher than expected and, interestingly, ganglioside headgroups seem to turn from cosmotropes to chaotropes upon collective rearrangement from the standing- to the lying-conformation. In a biological perspective, water structure modulation could be one of the physico-chemical elements contributing to the raft strategy, both for rafts formation and persistence and for their functional aspects. In particular, the interaction with approaching bodies could be favoured or inhibited or triggered by complex-sugar-sequence conformational switch. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Contrasting dynamics of fragile and non-fragile polyalcohols through the glass, and dynamical, transitions: A comparison of neutron scattering and dielectric relaxation data for sorbitol and glycerol.

    Science.gov (United States)

    Migliardo, F; Angell, C A; Magazù, S

    2017-01-01

    Glycerol and sorbitol are glass-forming hydrogen-bonded systems characterized by intriguing properties which make these systems very interesting also from the applications point of view. The goal of this work is to relate the hydrogen-bonded features, relaxation dynamics, glass transition properties and fragility of these systems, in particular to seek insight into their very different liquid fragilities. The comparison between glycerol and sorbitol is carried out by collecting the elastic incoherent neutron scattering (EINS) intensity as a function of temperature and of the instrumental energy resolution. Intensity data vs temperature and resolution are analyzed in terms of thermal restraint and Resolution Elastic Neutron Scattering (RENS) approaches. The number of OH groups, which are related to the connecting sites, is a significant parameter both in the glass transition and in the dynamical transition. On the other hand, the disordered nature of sorbitol is confirmed by the existence of different relaxation processes. From the applications point of view, glycerol and sorbitol have remarkable bioprotectant properties which make these systems useful in different technological and industrial fields. Furthermore, polyols are rich in glassforming liquid phenomenology and highly deserving of study in their own right. The comparison of EINS and calorimetric data on glycerol and sorbitol helps provide a connection between structural relaxation, dynamical transition, glass transition, and fragility. The evaluation of the inflection point in the elastic intensity behavior as a function of temperature and instrumental energy resolution provides a confirmation of the validity of the RENS approach. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo. Copyright © 2016. Published by Elsevier B.V.

  9. Economic evaluation of screening programs for hepatitis C virus infection: evidence from literature

    Directory of Open Access Journals (Sweden)

    Coretti S

    2015-04-01

    Full Text Available Silvia Coretti,1 Federica Romano,1 Valentina Orlando,2 Paola Codella,1 Sabrina Prete,1 Eugenio Di Brino,1 Matteo Ruggeri1 1Post-Graduate School of Economics and Management (ALTEMS, Università Cattolica del Sacro Cuore, Rome, Italy; 2Center of Pharmacoeconomics (CIRFF, Department of Pharmacy, Federico II University, Naples, Italy Background: Hepatitis C is a liver infection caused by hepatitis C virus. Its main complications are cirrhosis and liver cancer. According to the World Health Organization (WHO, more than 185 million people worldwide are infected with hepatitis C virus and, of these, 350,000 die every year. Due to the high disease prevalence and the existence of effective (and expensive medical treatments able to dramatically change the prognosis, early detection programs can potentially prevent the development of serious chronic conditions, improve health, and save resources. Objective: To summarize the available evidence on the cost-effectiveness of screening programs for hepatitis C. Methods: A literature search was performed on PubMed and Scopus search engines. Trip database was queried to identify reports produced by the major Health Technology Assessment (HTA agencies. Three reviewers dealt with study selection and data extraction blindly. Results: Ten papers eventually met the inclusion criteria. In studies focusing on asymptomatic cohorts of individuals at general risk the cost/quality adjusted life year of screening programs ranged between US $4,200 and $50,000/quality adjusted life year gained, while in those focusing on specific risk factors the incremental cost-effectiveness ratio ranged between $848 and $128,424/quality adjusted life year gained. Age of the target population and disease prevalence were the main cost-effectiveness drivers. Conclusion: Our results suggest that, especially in the long run, screening programs represent a cost-effective strategy for the management of hepatitis C. Keywords: hepatitis C, screening

  10. Combined Circumferential and Longitudinal Left Ventricular Systolic Dysfunction in Patients with Rheumatoid Arthritis without Overt Cardiac Disease.

    Science.gov (United States)

    Cioffi, Giovanni; Viapiana, Ombretta; Ognibeni, Federica; Dalbeni, Andrea; Gatti, Davide; Mazzone, Carmine; Faganello, Giorgio; Di Lenarda, Andrea; Adami, Silvano; Rossini, Maurizio

    2016-07-01

    Patients with rheumatoid arthritis have an increased risk for cardiovascular disease. Because of accelerated atherosclerosis and changes in left ventricular (LV) geometry, circumferential and longitudinal (C&L) LV systolic dysfunction (LVSD) may be impaired in these patients despite preserved LV ejection fraction. The aim of this study was to determine the prevalence of and factors associated with combined C&L LVSD in patients with rheumatoid arthritis. One hundred ninety-eight outpatients with rheumatoid arthritis without overt cardiac disease were prospectively analyzed from January through June 2014 and compared with 198 matched control subjects. C&L systolic function was evaluated by stress-corrected midwall shortening (sc-MS) and tissue Doppler mitral annular peak systolic velocity (S'). Combined C&L LVSD was defined if sc-MS was cite either of them in the other one and, afterward, we just did not think about this point anymore. Of note, the idea to combine in the analysis longitudinal function came therefore well after the starting process of revision of the paper E and was, in some way inspired by a reviewer's comment. That is why we did not put both findings in the same paper. We think that our explanations provide the broad audience of your journal a perspective of transparency and our respect for the readers' right to understand how the work described in the paper J relates to other work by our research group. Giovanni Cioffi On behalf of all co-authors Ombretta Viapiana, Federica Ognibeni, Andrea Dalbeni, Davide Gatti, Carmine Mazzone, Giorgio Faganello, Andrea Di Lenarda, Silvano Adami, and Maurizio Rossini. Copyright © 2016 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

  11. Risk of Essure microinsert abdominal migration: case report and review of literature

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    Ricci G

    2014-11-01

    Full Text Available Giuseppe Ricci,1,2 Stefano Restaino,2 Giovanni Di Lorenzo,1 Francesco Fanfani,1 Federica Scrimin,1 Francesco P Mangino1 1Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy; 2Department of Medical Sciences, University of Trieste, Trieste, Italy Purpose: To report a case of Essure microinsert abdominal migration and literature review.Methods: A 41-year-old woman was counseled to undergo Essure sterilization. The procedure was hampered by the presence of endometrial cavity adhesions, obscuring left tubal ostium. By using microscissors the adhesions were progressively lysed. Since the procedure had become very painful, the patient required general anesthesia. Once adhesion lysis was completed, the tubal ostium was well visible. Both devices were then easily introduced into the fallopian tubes. At the end of the procedure, five coils were visible on the right side and five coils on the left side, as recommended.Results: The 3-month hysterosalpingogram follow-up suspected abdominal migration of the left device. Laparoscopy confirmed the device displacement in the left lower abdominal quadrant. Both fallopian tubes and the uterus appeared normal. No signs of perforation were detected. The device was embedded into the omentum, but it was easily removed. Bilateral tubal sterilization was performed by bipolar coagulation.Conclusion: There are only 13 cases, including the present, of Essure abdominal migration in the literature. In most cases, abdominal displacement of the microinsert is asymptomatic and does not induce tissue damage. However, in some cases, it may cause a severe adverse event, requiring major surgery. Therefore, removal of the migrated device should be performed as soon as possible. Moreover, during presterilization counseling, the patient should also be correctly informed about the risk of this rare but relevant complication, as well as about the surgical interventions that could be required to solve it

  12. Treatment of refractory uveitic macular edema: results of a first and second implant of long-acting intravitreal dexamethasone

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    Zola M

    2017-11-01

    Full Text Available Marta Zola, Cristina Briamonte, Umberto Lorenzi, Federica Machetta, Federico M Grignolo, Antonio M Fea Ophthalmic Eye Hospital, Department of Surgical Sciences, University of Turin, Italy Purpose: The purpose of this study was to report the functional and anatomical outcomes of a prospective study resulting from repeated dexamethasone intravitreal implants in patients with uveitic refractory macular edema.Methods: Twelve eyes of 9 patients with intermediate and posterior noninfectious inflammatory uveitis complicated with refractory macular edema were regularly reviewed after a dexamethasone intravitreal implant. Patients were examined at baseline, 30, 90, 135, and 180 days with best-corrected visual acuity (BCVA, complete slit-lamp examination, intraocular pressure (IOP, optical coherence tomography, and fluorescein angiography. After 6 months of follow-up, eyes were reassessed to receive a second implant. Results: BCVA significantly improved when comparing the baseline values after the first and second implant (16.2 and 25.8 letters, respectively, 9.6 letters improvements, p<0.05. BCVA was better after the second implant compared to the first one throughout the follow-up, but without statistical significance. Mean central macular thickness (CMT was 446.3±129.9 µm at baseline and was significantly reduced until day 135 (p<0.05. CMT reductions after the second injection showed a similar pattern, though differences were not statistically significant. Cataract progression was observed in 4 of 8 phakic eyes (50% after the first implant, and in 2 of 3 phakic eyes following the second implant, with 1 eye requiring cataract surgery. One eye developed an IOP >30 mmHg 30 days after the second implant, treated topically.Conclusion: Repeated dexamethasone intravitreal implants in uveitic patients with refractory macular edema can be used effectively in a clinical setting with an acceptable safety profile. Keywords: uveitis, macular edema

  13. Topographic changes detection through Structure-from-Motion in agricultural lands affected by erosion processes

    Science.gov (United States)

    Prosdocimi, Massimo; Pradetto Sordo, Nicoletta; Burguet, Maria; Di Prima, Simone; Terol Esparza, Enric; Tarolli, Paolo; Cerdà, Artemi

    2016-04-01

    Throughout the world, soil erosion by water is a serious problem, especially in semi-arid and semi-humid areas (Cerdà et al., 2009; Cerdan et al., 2010; García-Ruiz, 2010). Although soil erosion by water consists of physical processes that vary significantly in severity and frequency according to when and where they occur, they are also strongly influenced by anthropic factors such as land-use changes on large scales and unsustainable farming practices (Boardman et al., 1990; Cerdà 1994; Montgomery, 2007). Tillage operations, combined with weather conditions, are recognized to primarily influence soil erosion rates. If, on one hand, tillage operations cause uniform changes based on the tool used, on the other, weather conditions, such as rainfalls, produce more random changes, less easily traceable (Snapir et al., 2014). Within this context, remote-sensing technologies can facilitate the detection and quantification of these topographic changes. In particular, a real opportunity and challenge is offered by the low-cost and flexible photogrammetric technique, called 'Structure-from-Motion' (SfM), combined with the use of smartphones (Micheletti et al., 2014; Prosdocimi et al., 2015). This represents a significant advance compared with more expensive technologies and applications (e.g. Terrestrial Laser Scanner - TLS) (Tarolli, 2014). This work wants to test the Structure from Motion to obtain high-resolution topography for the detection of topographic changes in agricultural lands affected by erosion processes. Two case studies were selected: i) a tilled plot characterized by bare soil and affected by rill erosion located in the hilly countryside of Marche region (central Italy), and ii) a Mediterranean vineyard located within the province of Valencia (south eastern Spain) where rainfall simulation experiments were carried out. Extensive photosets were obtained by using one standalone reflex digital camera and one smartphone built-in digital camera. Digital

  14. Alexithymia in eating disorders: therapeutic implications

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    Pinna F

    2014-12-01

    Full Text Available Federica Pinna, Lucia Sanna, Bernardo Carpiniello Department of Public Health, Clinical and Molecular Medicine - Unit of Psychiatry, University of Cagliari, Cagliari, Italy Abstract: A high percentage of individuals affected by eating disorders (ED achieve incomplete recovery following treatment. In an attempt to improve treatment outcome, it is crucial that predictors of outcome are identified, and personalized care approaches established in line with new treatment targets, thus facilitating patient access to evidence-based treatments. Among the psychological factors proposed as predictors of outcome in ED, alexithymia is of outstanding interest. The objective of this paper is to undertake a systematic review of the literature relating to alexithymia, specifically in terms of the implications for treatment of ED. In particular, issues concerning the role of alexithymia as a predictor of outcome and as a factor to be taken into account in the choice of treatment will be addressed. The effect of treatments on alexithymia will also be considered. A search of all relevant literature published in English using PubMed, PsycINFO, and Scopus databases was carried out on the basis of the following keywords: alexithymia, anorexia nervosa, bulimia nervosa, eating disorders, and treatment; no time limits were imposed. Despite the clinical relevance of alexithymia, the number of studies published on the above cited aspects is somewhat limited, and these studies are largely heterogeneous and feature significant methodological weaknesses. Overall, data currently available mostly correlate higher levels of alexithymia with a less favorable outcome in ED. Accordingly, alexithymia is seen as a relevant treatment target with the aim of achieving recovery of these patients. Treatments focusing on improving alexithymic traits, and specifically those targeting emotions, seem to show greater efficacy, although alexithymia levels often remain high even after specific

  15. Canonical cortical circuits: current evidence and theoretical implications

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    Capone F

    2016-04-01

    Full Text Available Fioravante Capone,1,2 Matteo Paolucci,1,2 Federica Assenza,1,2 Nicoletta Brunelli,1,2 Lorenzo Ricci,1,2 Lucia Florio,1,2 Vincenzo Di Lazzaro1,2 1Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy; 2Fondazione Alberto Sordi – Research Institute for Aging, Rome, ItalyAbstract: Neurophysiological and neuroanatomical studies have found that the same basic structural and functional organization of neuronal circuits exists throughout the cortex. This kind of cortical organization, termed canonical circuit, has been functionally demonstrated primarily by studies involving visual striate cortex, and then, the concept has been extended to different cortical areas. In brief, the canonical circuit is composed of superficial pyramidal neurons of layers II/III receiving different inputs and deep pyramidal neurons of layer V that are responsible for cortex output. Superficial and deep pyramidal neurons are reciprocally connected, and inhibitory interneurons participate in modulating the activity of the circuit. The main intuition of this model is that the entire cortical network could be modeled as the repetition of relatively simple modules composed of relatively few types of excitatory and inhibitory, highly interconnected neurons. We will review the origin and the application of the canonical cortical circuit model in the six sections of this paper. The first section (The origins of the concept of canonical circuit: the cat visual cortex reviews the experiments performed in the cat visual cortex, from the origin of the concept of canonical circuit to the most recent developments in the modelization of cortex. The second (The canonical circuit in neocortex and third (Toward a canonical circuit in agranular cortex sections try to extend the concept of canonical circuit to other cortical areas, providing some significant examples of circuit functioning in different cytoarchitectonic

  16. Nanotechnology versus stem cell engineering: in vitro comparison of neurite inductive potentials

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    Morano M

    2014-11-01

    Full Text Available Michela Morano,1,* Sandra Wrobel,2,3,* Federica Fregnan,1 Ofra Ziv-Polat,4 Abraham Shahar,4 Andreas Ratzka,2 Claudia Grothe,2,3 Stefano Geuna,1 Kirsten Haastert-Talini2,3 1Department of Clinical and Biological Sciences, Università Degli Studi di Torino, Orbassano, Piemonte, Italy; 2Institute of Neuroanatomy, Hannover Medical School, Hannover, Lower-Saxony, Germany; 3Center for Systems Neuroscience (ZSN, Hannover, Lower-Saxony, Germany; 4NVR Research Ltd, Ness-Ziona, Israel *These authors contributed equally to this work and share first authorship Purpose: Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits via nanotechnology or stem cell engineering and transplantation.Methods: Here, we comparatively investigated the bioactivity of selected neurotrophic factors conjugated to iron oxide nanoparticles (np-NTFs and of bone marrow-derived stem cells genetically engineered to overexpress those neurotrophic factors (NTF-BMSCs. The neurite outgrowth inductive activity was monitored in culture systems of adult and neonatal rat sensory dorsal root ganglion neurons as well as in the cell line from rat pheochromocytoma (PC-12 cell sympathetic culture model system.Results: We demonstrate that np-NTFs reliably support numeric neurite outgrowth in all utilized culture models. In some aspects, especially with regard to their long-term bioactivity, np-NTFs are even superior to free NTFs. Engineered NTF-BMSCs proved to be less effective in induction of sensory neurite outgrowth but demonstrated an increased bioactivity in the PC-12 cell culture system. In contrast, primary nontransfected BMSCs were as effective as np-NTFs in sensory neurite induction and demonstrated an impairment of neuronal differentiation in the PC-12

  17. Critical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia

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    Carpiniello B

    2016-05-01

    Full Text Available Bernardo Carpiniello, Federica Pinna Department of Public Health, Clinical and Molecular Medicine – Psychiatry Research Unit and Psychiatric Clinic, University Hospital, Cagliari, Italy Aims: Three-monthly injections of paliperidone palmitate (PP-3M represent a new and recently introduced long-acting antipsychotic therapeutic option. This review focuses on available data relating to the efficacy and safety of PP-3M and its position in the current therapeutic scenario.Method: An analysis of PubMed, Scopus, and ISI Web of Knowledge databases was conducted, and all available papers on PP-3M, including poster presentations, were selected and considered for the purpose of the present review. Findings: to date, three full papers have been published, the first, a Phase 1 randomized, open label study investigating the pharmacokinetics, safety, and tolerability of the drug; the second, a Phase 3 double blind study vs placebo focusing on efficacy and tolerability; and the last relating to the practical use of PP-3M. The five posters identified describe data reported in the above-cited papers. Overall, the pharmacokinetic findings obtained in these studies highlight the feasibility of administering PP-3M on a 3-monthly basis, subsequent to the administration of four 1-monthly injections of PP at doses 3.5 times higher than the stabilized dose of 1-monthly injections of PP (ie, 175, 300, 450, and 525 mgs. The published studies highlight a significantly longer time to relapse compared to placebo, and significantly better results compared to placebo for all secondary end-points (Positive and Negative Syndrome Scale, Clinical Global Impression-Severity Scale, Personal and Social Performance Scale scores, in addition to reasonably good safety and tolerability profiles.Conclusion: PP-3M emerges as a potential candidate for use as a first-line long-acting agent in the maintenance treatment of patients with schizophrenia. Further studies should however be

  18. Welcome greetings from Biblioteca Nazionale Centrale di Firenze

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    Silvia Alessandri

    2018-01-01

    Full Text Available A nome del direttore, dottor Luca Bellingeri, porto il saluto della Biblioteca Nazionale Centrale di Firenze agli organizzatori, ai relatori e ai presenti a questo importante convegno. Il fatto che  il Convegno annuale di EURIG (il gruppo d'interesse europeo per RDA si tenga per la prima volta in Italia e a Firenze, non può che rivestire un particolare valore e interesse per la Biblioteca Nazionale Centrale di Firenze (BNCF per più motivi. La BNCF, infatti, nella sua duplice funzione di Agenzia bibliografica nazionale con la produzione della BNI (oggi aperta e gratuita, e di elaborazione degli strumenti nazionali aperti di indicizzazione semantica (il Nuovo Soggettario, contribuisce attivamente all'evoluzione dell'universo bibliografico e della scienza dell'informazione, all'interno del quale lo standard internazionale RDA rappresenta un punto di confronto imprescindibile.  Si può ricordare in proposito che la BNCF ha fatto parte (con Francesca Socci e Federica Paradisi, del Gruppo di lavoro tecnico dell'ICCU per la traduzione italiana di RDA, ed ha per prima presentato in sede in forma seminariale il Manuale RDA di Guerrini e Bianchini (4 ottobre 2016. Si può inoltre considerare che lo standard RDA è destinato a descrivere e dare accesso alle risorse in rete di qualsiasi tipologia e natura, fornendo strumenti di relazione fra le raccolte delle biblioteche degli archivi e dei musei: lo stesso terreno  in cui si svolge l'impegno attivo della BNCF all'interno del gruppo toscano Linguaggi del MAB (gruppo nazionale Musei-Archivi-Biblioteche, ed altrettanto avviene per quanto riguarda la tematica dell'Interoperabilità nel Web semantico.  Pur essendo nato in ambito bibliografico -a partire da FRBR- RDA si propone come standard universale di metadatazione non esclusivamente bibliografico, rispetto al quale anche i Codici nazionali di catalogazione possono porsi in modo dialettico e collaborativo per una reciproca evoluzione nell

  19. Polymeric nanoparticles enhance the sonodynamic activity of meso-tetrakis (4-sulfonatophenyl porphyrin in an in vitro neuroblastoma model

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    Canaparo R

    2013-11-01

    Full Text Available Roberto Canaparo,1,* Greta Varchi,2,* Marco Ballestri,2 Federica Foglietta,1 Giovanna Sotgiu,2 Andrea Guerrini,2 Andrea Francovich,3 Pierluigi Civera,3 Roberto Frairia,4 Loredana Serpe1 1Department of Drug Science and Technology, University of Torino, Torino, Italy; 2Institute of the Organic Synthesis and Photoreactivity, National Research Council, Bologna, Italy; 3Departments of Electronics, Politecnico of Torino, Torino, Italy; 4Department of Medical Science, University of Torino, Torino, Italy *These authors contributed equally to this work Purpose: Sonodynamic therapy is a developing noninvasive modality for cancer treatment, based on the selective activation of a sonosensitizer agent by acoustic cavitation. The activated sonosensitizer agent might generate reactive oxygen species leading to cancer cell death. We investigated the potential poly-methyl methacrylate core-shell nanoparticles (NPs loaded with meso-tetrakis (4-sulfonatophenyl porphyrin (TPPS have to function as an innovative sonosensitizing system, ie, TPPS-NPs. Methods: Shockwaves (SWs generated by a piezoelectric device were used to induce acoustic cavitation. The cytotoxic effect of the sonodynamic treatment with TPPS-NPs and SWs was investigated on the human neuroblastoma cell line, SH-SY5Y. Cells were exposed for 12 hours to TPPS-NPs (100 µg/mL and then to SWs (0.43 mJ/mm2 for 500 impulses, 4 impulses/second. Treatment with SWs, TPPS and NPs alone or in combination was carried out as control. Results: There was a statistically significant decrease in SH-SY5Y cell proliferation after the sonodynamic treatment with TPPS-NPs and SWs. Indeed, there was a significant increase in necrotic (16.91% ± 3.89% and apoptotic (27.45% ± 3.03% cells at 48 hours. Moreover, a 15-fold increase in reactive oxygen species production for cells exposed to TPPS-NPs and SWs was observed at 1 hour compared with untreated cells. A statistically significant enhanced mRNA (messenger ribonucleic acid

  20. CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats

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    Meregalli C

    2012-06-01

    Full Text Available Cristina Meregalli,1 Cecilia Ceresa,1 Annalisa Canta,1 Valentina Alda Carozzi,1 Alessia Chiorazzi,1 Barbara Sala,1 Norberto Oggioni,1 Marco Lanza,2 Ornella Letar,i2 Flora Ferrari,2 Federica Avezza,1 Paola Marmiroli,1 GianFranco Caselli,2 Guido Cavaletti11Department of Neuroscience and Biomedical Technologies, University of Milan-Bicocca, 2Pharmacology and Toxicology Department, Rottapharm | Madaus Research Center, Monza, ItalyAbstract: Although bortezomib (BTZ is the frontline treatment for multiple myeloma, its clinical use is limited by the occurrence of painful peripheral neuropathy, whose treatment is still an unmet clinical need. Previous studies have shown chronic BTZ administration (0.20 mg/kg intravenously three times a week for 8 weeks to female Wistar rats induced a peripheral neuropathy similar to that observed in humans. In this animal model of BTZ-induced neurotoxicity, the present authors evaluated the efficacy of CR4056, a novel I2 ligand endowed with a remarkable efficacy in several animal pain models. CR4056 was administered in a wide range of doses (0.6–60 mg/kg by gavage every day for 2–3 weeks in comparison with buprenorphine (Bupre (28.8 µg/kg subcutaneously every day for 2 weeks and gabapentin (Gaba (100 mg/kg by gavage every day for 3 weeks. Chronic administration of BTZ reduced nerve conduction velocity and induced allodynia. CR4056, Bupre, or Gaba did not affect the impaired nerve conduction velocity. Conversely, CR4056 dose-dependently reversed BTZ-induced allodynia (minimum effective dose 0.6 mg/kg. The optimal dose found, 6 mg/kg, provided a constant pain relief throughout the treatment period and without rebound after suspension, being effective when coadministered with BTZ, starting before or after allodynia was established, or when administered alone after BTZ cessation. A certain degree of tolerance was seen after 7 days of administration, but only at the highest doses (20 and 60 mg/kg. Bupre was effective

  1. 5th National Congress of the Italian Society of Physiotherapy

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    Alessandro Aina

    2016-10-01

    Plebani P26 Consistency in locating pressure stimuli over the lumbar spine on a digital body chart: a comparison between chronic low back pain patients and healthy subjects Federica Moresi, Marco Barbero, Matteo Isnardi, Alberto Gallace, Corrado Cescon, Roberto Gatti P27 Malignant Cord Compression in the thoraco-lumbar spine. Early signs and symptoms in the differential diagnosis of low back pain Moretti N, Maselli, Testa M. P28 End growth results of exercise treatment to avoid bracing in adolescents with idiopathic scoliosis: a prospective cohort controlled study Stefano Negrini, Sabrina Donzelli, Francesco Saveri, Alessandra Negrini, Silvana Parzini, Michele Romano, Fabio Zaina P29 Reliability of the Ashworth scale and its modified versions: systematic review and meta-analysis Leonardo Nesi, Francesco Ferrarello, Valeria Anna Maria Bianchi, Matteo Paci P30 Differences in motor recovery between upper and lower limbs in stroke subtypes Matteo Paci, Luca Nannetti, Bruna Lombardi P31 Influence of clinical experience on the reliability of the Salford Gait Tool Giuditta Mini, Mariangela Marchettini, Francesco Ferrarello, Matteo Paci P32 A somatosensory discrimination training induces brain functional changes in healthy young subjects Fabio Piccolo, Federica Agosta, Elisabetta Sarasso, Paola Adamo, Federico Temporiti, Andrea Falini, Roberto Gatti, Massimo Filippi P33 Effects of dynamic tilt-table with integrated robotic stepping associated with functional electrical stimulation: a cross-over study Daniele Piscitelli, Roberto Meroni, Leonardo Pellicciari, Marco A. Mondelli, Thomas Favaron, Cesare G. Cerri, Enrico A. Tallarita P34 Manual therapy techniques in the treatment of whiplash and its associated disorders: a systematic review Ravizzotti Elisa, Vercelli Stefano P35 The Patient and Observer Scar Assessment Scale (POSAS as a screening tool for early detection of pathologic post-surgical scars in physiotherapy Rossetti Sara, Ciceri Matteo, Vercelli Stefano P36 The anatomical

  2. Implementación de la guía de buenas prácticas: valoración del riesgo y prevención de úlceras por presión: experiencia en la Fundación Oftalmológica de Santander (FOSCAL / Implementation of the Good Practices Guide: Risk Assessment and Prevention of Pressure Ulcers, an Experience at “Fundacion Oftalmológica of Santander” (FOSCAL / Implementando do manual de boas práticas: avaliação do risco e prevenção de úlceras de pressão: experiênciana Fundação Oftalmológica do Santander (FOSCAL

    Directory of Open Access Journals (Sweden)

    Maribel Esparza-Bohórquez

    2016-11-01

    porcentaje de valoración del riesgo, seguimiento y revaloración durante la hospitalización. [Esparza-Bohórquez M, Granados-Oliveros LM, Joya-Guevara K. Implementación de la guía de buenas prácticas: valoración del riesgo y prevención de úlceras por presión: experiencia en la Fundación Oftalmológica de Santander (FOSCAL. MedUNAB 2016; 19(2: 115-123].

  3. Ammonium glycyrrhizinate-loaded niosomes as a potential nanotherapeutic system for anti-inflammatory activity in murine models

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    Marianecci C

    2014-01-01

    Full Text Available Carlotta Marianecci,1 Federica Rinaldi,1 Luisa Di Marzio,2 Marica Mastriota,3 Stefano Pieretti,3 Christian Celia,2,4 Donatella Paolino,5 Michelangelo Iannone,6,7 Massimo Fresta,5 Maria Carafa11Department of Drug Chemistry and Technologies, University Sapienza of Rome, Rome, 2Department of Pharmacy, University G d'Annunzio of Chieti of Pescara, Chieti, 3Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy; 4Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA; 5Department of Health Sciences, University Magna Graecia of Catanzaro, University Campus S Venuta, Building of BioSciences, Germaneto, 6ARPA Calabria, Environmental Epidemiology Center, 7CNR, Neuroscience Institute, Pharmacology Section, Complesso "Nini Barbieri", Roccelletta di Borgia, ItalyBackground: Liquorice extracts demonstrate therapeutic efficacy in treating dermatitis, eczema, and psoriasis when compared with corticosteroids. In this work, nonionic surfactant vesicles (niosomes, NSVs containing polysorbate 20 (Tween 20, cholesterol, and cholesteryl hemisuccinate at different molar concentrations were used to prepare monoammonium glycyrrhizinate (AG-loaded NSVs. The anti-inflammatory properties of AG-loaded NSVs were investigated in murine models.Methods: The physicochemical properties of the NSVs were characterized using dynamic light scattering. The fluidity of the lipid bilayer was evaluated by measuring the fluorescence intensity of diphenylhexatriene. The drug entrapment efficiency of AG was assessed using high-performance liquid chromatography. The physicochemical stability of the NSVs was evaluated as a function of time using dynamic light scattering combined with Turbiscan Lab® Expert analysis. Serum stability was determined by incubating the NSVs with 10% v/v fetal bovine serum. The cytotoxic effects of the NSVs were investigated in human dermal fibroblasts using the Trypan blue dye

  4. PREFACE: EPS Euroconference XIX Nuclear Physics Divisional Conference: New Trends in Nuclear Physics Applications and Technology

    Science.gov (United States)

    2006-06-01

    . Role of Nuclear Techniques in Environment Problems. Applications of Nuclear Techniques relevant for Civil Security (contraband and explosive detection, search for Weapons of Mass Destruction, Nuclear Safeguards). Nuclear Applications in Space Research. Material and Structure Testing in Research and Industry. New contributions of Nuclear Techniques to the solution of the Energy Production problems and Nuclear Waste Transmutation. Emerging experimental techniques, new detectors and new modeling tools. During the Monday morning Session of the Conference, the 2005 IBA-EUROPHYSICS PRIZE for Applied Nuclear Science and Nuclear Methods in Medicine, sponsored by the Belgian company IBA, was awarded to the two laureates Werner Heil (Mainz) and Pierre Jean Nacher (Paris) for the development of spin polarized 3He targets by optical pumping and their applications in nuclear science and medicine. The meeting was a real success, with 18 invited talks, 66 contributed talks and 31 posters and an overall participation, during five full days, of around 150 scientists from different European and non-European countries. It also hosted a three day industrial exhibition of a selection of Companies that sponsored the event. The Organisers take thos opportunity to thank the University of Pavia, the Amministrazione Comunale di Pavia and the Provincia di Pavia, as well as all exhibitors (Ametek, Ansaldo Superconduttori, Caen, Else, Hamamatsu, IBA, Micos, Micron Semiconductor), for their support of the Conference. The Organisers finally wish to thank the Scientific Secretary of the Conference, Dr Andrea Fontana of INFN Pavia, for the huge amount of work done in preparing the Conference, Mr Claudio Casella of the Department of Nuclear and Theoretical Physics of the University of Pavia for technical support and the Conference staff, Dr Gaia Boghen and the graduate students Federica Devecchi and Silvia Franchino, for their invaluable help. The very effective and professional work of the staff of

  5. Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice

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    Dell’Osso B

    2015-07-01

    Full Text Available Bernardo Dell’Osso,1,2,* Umberto Albert,3,* Anna Rita Atti,4 Claudia Carmassi,5 Giuseppe Carrà,6 Fiammetta Cosci,7 Valeria Del Vecchio,8 Marco Di Nicola,9 Silvia Ferrari,10 Arianna Goracci,11 Felice Iasevoli,12 Mario Luciano,8 Giovanni Martinotti,13 Maria Giulia Nanni,14 Alessandra Nivoli,15,16 Federica Pinna,17 Nicola Poloni,18 Maurizio Pompili,19 Gaia Sampogna,8 Ilaria Tarricone,20 Sarah Tosato,21 Umberto Volpe,8 Andrea Fiorillo8 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Bipolar Disorders Clinic, Stanford Medical School, Stanford University, CA, USA; 3Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, 4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK; 7Department of Health Sciences, University of Florence, Florence, 8Department of Psychiatry, University of Naples SUN, Naples, 9Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, 10Department of Diagnostic-Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, 11Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, 12Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, 13Department of Neuroscience, Imaging, and Clinical Science, University G.d Annunzio, Chieti-Pescara, 14Section of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 15Psychiatric Institute, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy; 16Bipolar Disorder Unit, CIBERSAM, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain; 17Department of

  6. PhD Dissertations Tesi di dottorato

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    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  7. Environmental change during the Late Berriasian - Early Valanginian: a prelude to the late Early Valanginian carbon-isotope event?

    Science.gov (United States)

    Morales, Chloé; Schnyder, Johann; Spangenberg, Jorge; Adatte, Thierry; Westermann, Stephane; Föllmi, Karl

    2010-05-01

    -746. F^llmi, K.B., Bodin, S., Godet, A., Linder, P. and Van de Schootbrugge, B. (2007). "Unlocking paleo-environmental information from Early Cretaceous shelf sediments in the Helvetic Alps: stratigraphy is the key!" Swiss j. geosci. 100: 349-369. Gr^cke, D.R., Price, G.D., Robinson, S.A., Baraboshkin, E.Y., Mutterlose, J. and Ruffell, A.H. (2005). "The Upper Valanginian (Early Cretaceous) positive carbon-isotope event recorded in terrestrial plants." Earth and Planetary Science Letters 240(2): 495-509. Hallam, A., Grose, J.A. and Ruffell, A.H. (1991). "Palaeoclimatic significance of changes in clay mineralogy across the Jurassic-Cretaceous boundary in England and France." Palaeogeography, Palaeoclimatology, Palaeoecology 81(3-4): 173-187. Hennig, S. (2003). Geochemical and sedimentological evidence for environmental changes in the Valanginian (Early Cretaceous) of the Tethys region, ETH Zurich: 189. Ogg, J.G., Ogg, G., Gradstein, F.M., 2008. The concise geological time scale. Cambridge University Press. 177 pp. Reboulet, S., Mattioli, E., Pittet, B., Baudin, F., Olivero, D. and Proux, O. (2003). "Ammonoid and nannoplankton abundance in Valanginian (early Cretaceous) limestone-marl successions from the southeast France Basin: carbonate dilution or productivity?" Palaeogeography, Palaeoclimatology, Palaeoecology 201(1-2): 113-139. Schnyder, J., Baudin, F. and Deconinck, J.-F. (2009). "Occurrence of organic-matter-rich beds in Early Cretaceous coastal evaporitic setting (Dorset, UK): a link to long-term palaeoclimate changes?" Cretaceous Research 30: 356-366. Van de Schootbrugge, B., Kuhn, O., Adatte, T., Steinmann, P. and F^llmi, K. (2003). "Decoupling of P- and Corg-burial following Early Cretaceous (Valanginian-Hauterivian) platform drowning along the NW Tethyan margin." Palaeogeography, Palaeoclimatology, Palaeoecology 199(3-4): 315-331. Westermann, S., F^llmi, K.B., Adatte, T., Matera, V., Schnyder, J., Fleitmann, D., Fiet, N., Ploch, I. and Duchamp-Alphonse, S. "The

  8. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.

    Science.gov (United States)

    Segré, C

    2010-01-01

    with other prestigious research centres and to create connections for future post docs or job experiences. And last but not least, it is a golden chance for penniless PhD students to spend a couple of extra days visiting a foreign country (this motivation will of course never be voiced to supervisors).The network of participating institutes has a three-nation core, made up of the Netherlands Cancer Institute, the Italian European School of Molecular Medicine (SEMM) and five UK Cancer Research Institutes (The London Research Institute, The Cambridge Research Institute, The Beatson Institute for Cancer Research in Glasgow, The Patterson Institute for Cancer Research in Manchester and the MRC Gray Institute for Radiation Oncology and Biology in Oxford).The conference is hosted and organised every year by one of the core institutes; the first was in Cambridge in 2007, Amsterdam in 2008 and London in 2009, this year was the turn of Milan.In addition to the core institutes, PhD students from several other high-profile institutes are invited to attend the conference. This year participants applied from the Spanish National Cancer Centre (CNIO, Madrid), the German Cancer Research Centre (DKFZ, Heidelberg), the European Molecular Biology Labs (EMBL, Heidelberg) and the San Raffaele Institute (HSR, Milan). Moreover four 'special guests' from the National Centre for Biological Sciences of Bangalore (India) attended the conference in Milan. This represents a first step in widening the horizons beyond Europe into a global worldwide network of talented PhD students in life sciences.The conference spread over two and a half days (Wednesday 19th to Friday 21st May) and touched on a broad spectrum of topics: from basic biology to development, from cancer therapies to modelling and top-down new generation global approaches. The final selection of presentations has been a tough task for us organisers (Chiara Segré, Federica Castellucci, Francesca Milanesi, Gianluca Varetti and Gian

  9. Selected Lectures of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-10-01

    Full Text Available Selected Lectures of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016LECT 1. NEONATAL CONGENITAL HEART DISEASE: WHAT'S NEW? • S. Costa, U. BottoneLECT 2. THE PRETERM NEWBORN INFANT WITH PATENT DUCTUS ARTERIOSUS: TO TREAT IT? HOW TO MANAGE IT? WHEN TO TREAT IT? • C. CavalliLECT 3. CONGENITAL CARDIOPATHies IN CHILDREN WITH DOWN SYNDROME • P. Neroni, R. Pintus, A. Dessì, M. Carboni, S. Floris, G. Ottonello, V. FanosLECT 4. FROM FETUS TO ADULTHOOD: THE YOUNG ADULT WITH CONGENITAL HEART DISEASE (ACHD • M. Chessa, E. Conforti, A. Micheletti, D.G. Negura, L. Giugno, A. Varrica, M. Lorito, A. GiambertiLECT 5. RESEARCH NEWS IN CARDIOLOGY: FROM FETUS TO ADULT PATIENT • P.P. BassareoLECT 6. ADVANCED SIMULATION IN NEONATOLOGY, MARGIN NOTES ON A METICULOUS TAILORING JOB • A. Cuttano, R.T. Scaramuzzo, M. Ciantelli, E. Sigali, A. BoldriniLECT 7. THORACIC ULTRASOUND IN NEONATOLOGY: PRESENT AND FUTURE • D. De LucaLECT 8. MAGNETIC RESONANCE IMAGING IN NEONATAL ASPHYXIA • M. Marras, A. Lai, L. Saba, P.P. Bassareo, L. Scarciolla, D. LongoLECT 9. INTRAOSSEOUS VASCULAR ACCESS IN PRETERM NEONATES • A. Lai, V. Masile, M. MarrasLECT 10. THE EARLY GUT COLONIZATION IN NEWBORNS • G. BiasucciLECT 11. MICROBIOTA AND PROBIOTICS • M. CorpinoLECT 12. ORGANIZATION, TRAINING AND CHARACTERISTICS OF COTTOLENGO VOLUNTEERING • L. MarchisioLECT 13. HEALTH SITUATION AND EPIDEMIOLOGY IN THE COTTOLENGO'S MISSIONS • E. ScalabrinoLECT 14. MATERNAL AND CHILD SERVICES AND CARING NEEDS • I. FarnetaniLECT 15. GIVING BIRTH IN RURAL AFRICA: CHALLENGES AND ADVANCES IN A REFERRAL SITE • G. GaidoLECT 16. COTTOLENGO MISSION HOSPITAL CHAARIA (KENYA: BORN IN A BUSH HOSPITAL • R. CavalliniLECT 17. DENTISTRY IN KENYA, THE STORY OF CHAARIA • G. FarneseLECT 18. VOLUNTEERS NURSES IN CHAARIA • S. FerranteLECT 19. SURGERY IN THIRD WORLD COUNTRIES: THE EXPERIENCE OF THE COTTOLENGO MISSION HOSPITAL • V. RussoLECT 20. THE HUMAN

  10. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

    Science.gov (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François

    2011-07-01

    ESevertsov Inst. of Ecology and Evolution, RU KÜCK AUniv. Bremen, DE KUO Y-MChung Hwa University, TW KVITEK LPalacky Univ., CZ LABILLE JCEREGE, FR LAMMINEN EDekati, FI LARUE CCEA, FR LE BIHAN OINERIS, FR LE DUR DEcomesure, FR LECERF PCILAS, FR LEGRAND MCordouan, FR LELONG CUJF CEA, FR LIMOUSIN SINERIS, FR LINDELOEV JGEA Process Engineering, DK LIU P PChina Jiliang University, CN LIU WCEREGE, FR MACHEREY A-CCNRS, FR MAGGA YCEA, FR MAHLENDORF FUniversity Duisburg-Essen, DE MANIER NINERIS, FR MANZO LUniv. Pavia, IT MARCHETTO ACEA, FR MARCONE GUNICAMP, BR MARI DEPFL, CH MARIE-DESVERGNE CCEA, FR MARIE-LOUISE APSA Peugeot-Citroen, FR MARMUSE LNano-H S.A.S., FR MARRA JPhilips Research Aerasense, NL MASION ACEREGE, FR MATEI EPolitehnica University Bucharest, RO MATSUI YKyoto Univ., JP MATZKE MUniv. Gothenburg, SE MAYNE-L'HERMITE MCEA, FR MELINTE G ABabes-Bolyai University, RO MERINO CGrupo Antolin Ingenieria, ES MICHAUD-SORET ICEA, FR MICHELETTI CJRC, IT MONTIGEL EBasler Versicherungen, CH MONTOYA ERAMEM, ES MOSSUZ VCEA, FR MOTELLIER SCEA, FR MOTZKUS CLNE, FR MUIR BNaneum, GB NAKAMURA KJAPAN NUS CO., JP NEUBAUER NKarlsruhe Institute of Technologie, DE NEUMEISTER LBG ETEM, DE NGUYEN TNIST, US NIORT NINTERTEK, FR NOIRTIN AINTERTEK, FR NOWACK BEmpa, CH NYEMBE DUniv. Johannesburg, ZA Ó CLAONADH NDublin Institute of Technology, IE OBERDÖRSTER GUniv. Rochester, US OGURA IAIST, JP OSTIGUY CIRSST, CA OTSUKA KJFE Techno-Research Corp., JP OUF F-XIRSN, FR OUSACI SALMA, FR PAGET VCEA, FR PAILLEUX MEcole des Mines de Saint Etienne, FR PANDARD PINERIS, FR PANZER OEuropean Research Services, DE PARISELLI FCNRS, FR PERLET JNANO Magazine, GB PETERS RRIKILT, NL PETIT A-NCEA, FR PETKOVIC JNational Institute of Biology, SI PIMENOFF JBeneq, FI PINAULT MCEA, FR PIRET J-PUniv. Namur, BE PONTONE RTekna Plasma Systems, FR POURCHEZ JEcole des Mines de Saint Etienne, FR PRAETORIUS AETH Zurich, CH PRAT OCEA, FR PREVENSLIK TQED Radiations, CN PREVOST CIRSN, FR PROY HUART DFrance Nature Environnement, FR PUI

  11. El proyecto “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA: 15 años construyendo un activo institucional de la Universidad Autónoma de Bucaramanga-UNAB / Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas Disease Project. CHICAMOCHA: 15 Years Building an Asset for The Universidad Autónoma de Bucaramanga-UNAB / O Projeto Cardiovascular Investigação de Saúde e colaboração para avaliar os marcadores e resultados da doença de Chagas CHICAMOCHA: 15 anos construindo um ativo institucional na Universidade Autônoma de Bucaramanga-UNAB

    Directory of Open Access Journals (Sweden)

    Juan Carlos Villar-Centeno, MD., Esp., MSc., PhD

    2015-07-01

    Full Text Available El 3 de mayo del año 2000 asistió a una oficina de la entonces naciente Facultad de Medicina de la Universidad Autónoma de Bucaramanga (UNAB, quien fuera el primer participante de un proyecto llamado “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA. Su estudio piloto, planeado para un año, fue financiado por el departamento de ayudas a la comunidad de ECOPETROL (a través de un convenio con el ISABU, firmado por el entonces director, el actual decano de la facultad, Dr. Juan José Rey. El apoyo dado por el director de investigaciones de la UNAB, Dr. Germán Oliveros, y el decano en la época, Dr. Juan Carlos Mantilla encontró un rector dispuesto, el Dr. Gabriel Burgos Mantilla, que equiparó el apoyo económico con el del patrocinador externo. Con ese soporte, bajo la coordinación del Dr. Luis Ángel Villar, el equipo de trabajo inicial (Víctor Mauricio Herrera, médico, Martha Vásquez, enfermera y Claudia Ríos, secretaria inició este proyecto. CHICAMOCHA fue concebido para que – estudiando donantes de sangre con pruebas de tamización positivas o negativas para Trypanosoma cruzi en una relación 1:4 – se sirvieran dos propósitos: El primero era facilitar el estudio del diagnóstico temprano de la cardiomiopatía de Chagas, por comparación con su contraparte de seronegativos; el segundo, a mayor plazo, era construir una cohorte de adultos jóvenes clínicamente sanos. Esto permitiría, luego de varios años de observación, contribuir al estudio de la enfermedad cardiovascular de origen aterosclerótico y sus factores de riesgo, como aporte al conocimiento de las enfermedades crónicas no transmisibles (ECNT en nuestro medio. En esta editorial haremos énfasis en la segunda meta, cumplida más de una década después. Luego de varios intentos por superar las dificultades logísticas, se logra conseguir financiación de Colciencias para reevaluar los

  12. Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-10-01

    . BiasucciABS 83. PLACENTAL CALCIFICATIONS: OCCURRENCE AND CLINICAL RELEVANCE • A. Locci, A. Pili, F. Frongia, E. Obinu, C. Rossi, D. Fanni, C. GerosaABS 84. METABOLOMICS DIFFERENCES IN PATIENTS WITH BICUSPID AORTIC VALVE WITH AND WITHOUT ASCENDING AORTA DILATATION: A COMPARATIVE PROSPECTIVE STUDY • E. Conforti, A. Dessi, A. Noto, A. Giamberti, A. Varrica, D.G. Negura, A. Micheletti, L. Giugno, A.F. D'Aiello, L. Piazza, G. Butera, M. Carminati, M. ChessaABS 85. THE GREIG CEPHALOPOLYSYNDACTYLY SYNDROME: A SUSPECTED CASE REPORT • A. Murianni, A. Atzei, S. Floris, M.E. Trudu, E. Longobardi, A. Manconi, G. Secci, G. OttonelloABS 86. A NEW APPROACH TO THE DIAGNOSIS OF CONGENITAL TOXOPLASMOSIS IN NEWBORNS • L. Bollani, C. Achille, C. Tzialla, M. Prestia, F. Genco, V. MeroniABS 87. A RARE CASE OF NEONATAL INTUSSUSCEPTION • I. Pezone, G. Della Corte, G. Golia, M. Capasso, M. Sibilio, R. Mormile, C. Fusco, A. Colasanto, C. Cioffi, A. Colella, A. Perrotta, M.T. Russo, R. Coppola, D. PerriABS 88. URINARY GC/MS METABOLOMICS IN ASPHYXIATED NEWBORNS UNDERGOING HYPOTHERMIA: FROM BIRTH TO 72 HOURS OF LIFE • L. Barberini, G. Pomero, C. Dalmazzo, C. Fattuoni, A. Noto, A. Dessì, L. Giua Marassi, R. Pintus, M. Puddu, G. Palmas, V. Fanos, P. GanciaABS 89. PRENATAL SUBSTANCE USE: THE EXPERIENCE LIVED BY THE NEWBORN • A. Murianni, E. Serra, A. Atzei, S. Floris, M.E. Trudu, E. Longobardi, A. Manconi, G. Secci, G. OttonelloABS 90. A RARE CASE OF CONGENITAL EPICRANIAL pPNET: THE IMPORTANCE OF ULTRASOUND FOLLOW-UP • P. Paladini, A. Paladini, G. Sticchi, A. Pauciulo

  13. Selected Abstracts of the 9th International Workshop on Neonatology; Cagliari (Italy; October 23-26, 2013

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2013-06-01

    follow-up path for preterm children • G. Perricone, C. Polizzi, M.R. Morales, A. Faucetta, J. Caldas Luizeiro; Palermo (Italy ABS 53. When breast is not the best: a case of severe allergic proctocolitis • A.P. Pinna, F. Sau, S. Pusceddu, C. Serra, R. Puxeddu, A. Putzu, A.M. Nurchi; Cagliari (Italy ABS 54. Fetal thrombotic vasculopathy (FTV and neonatal outcome: the importance of histological examination • F. Magnetti, G. Botta, R. Bagna, P. Saracco, A. Viano, G. Dorati, S. Carbonati, E. Bobba, C. Tortone, F. Chiale, E. Bertino; Turin (Italy ABS 55. Surveillance of fungal colonizations in surgical neonates in Neonatal Intensive Care Unit • F. Serraino, C. Maida, M. Allegro, F. Nociforo, M. Giuffrè, G. Corsello; Palermo (Italy ABS 56. Fetal maternal alloimmunization: therapy and outcomes in a large cohort study • M. Federica, B. Rossana, P. Saracco, C. Tortone, G. Dorati, M. Mensa, F. Chiale, M. Pavan, D. Peruccio, R. Mazzone, E. Bobba, S. Carbonati; Turin (Italy ABS 57. Correlation between impedance patterns and clinical outcome in newborns with symptoms of gastroesophageal reflux • E. Maggiora, F. Cresi, E. Locatelli, A. Pirra, C. Tortone, F. Chiale, L. Occhi, A. Coscia, S. Borgione, C. Martano, L. Ferrero, E. Bertino; Turin (Italy ABS 58. Urinary excretion of NGAL (neutrophil gelatinase associated lipocalin at birth is predictive of acute kidney injury (AKI in very low birth weight infants • F. Chiale, L. Peruzzi, E. Maggiora, M.E. Donadio, M. Raia, S. Carbonati, R. Camilla, C. Martano, F. Cresi, E. Marcianò, R. Coppo, E. Bertino; Turin (Italy ABS 59. Influence of circadian rhythms on gastroesophageal reflux in newborns • E. Maggiora, F. Cresi, E. Locatelli, E. Cester, E. Marcianò, A. Pirra, F. Chiale, L. Occhi, A. Coscia, L. Di Leo, P. Murru, E. Bertino; Turin (Italy ABS 60. Impact of pregnancy and labour complications on neonatal outcomes: a retrospective cohort study in a rural hospital of Ethiopia • E. Bobba, M. Fascendini, F. Magnetti, M. Raia