Energy Technology Data Exchange (ETDEWEB)
Keriquel, Virginie; Guillemot, Fabien; Arnault, Isabelle; Guillotin, Bertrand; Amedee, Joelle; Fricain, Jean-Christophe; Catros, Sylvain [INSERM, U577, Bordeaux, F-33076 (France) and Universite Victor Segalen Bordeaux 2, UMR-S577 Bordeaux, F-33076 (France); Miraux, Sylvain [Centre de Resonance Magnetique des Systemes Biologiques, UMR 5536 (France)
2010-03-15
We present the first attempt to apply bioprinting technologies in the perspective of computer-assisted medical interventions. A workstation dedicated to high-throughput biological laser printing has been designed. Nano-hydroxyapatite (n-HA) was printed in the mouse calvaria defect model in vivo. Critical size bone defects were performed in OF-1 male mice calvaria with a 4 mm diameter trephine. Prior to laser printing experiments, the absence of inflammation due to laser irradiation onto mice dura mater was shown by means of magnetic resonance imaging. Procedures for in vivo bioprinting and results obtained using decalcified sections and x-ray microtomography are discussed. Although heterogeneous, these preliminary results demonstrate that in vivo bioprinting is possible. Bioprinting may prove to be helpful in the future for medical robotics and computer-assisted medical interventions.
International Nuclear Information System (INIS)
Keriquel, Virginie; Guillemot, Fabien; Arnault, Isabelle; Guillotin, Bertrand; Amedee, Joelle; Fricain, Jean-Christophe; Catros, Sylvain; Miraux, Sylvain
2010-01-01
We present the first attempt to apply bioprinting technologies in the perspective of computer-assisted medical interventions. A workstation dedicated to high-throughput biological laser printing has been designed. Nano-hydroxyapatite (n-HA) was printed in the mouse calvaria defect model in vivo. Critical size bone defects were performed in OF-1 male mice calvaria with a 4 mm diameter trephine. Prior to laser printing experiments, the absence of inflammation due to laser irradiation onto mice dura mater was shown by means of magnetic resonance imaging. Procedures for in vivo bioprinting and results obtained using decalcified sections and x-ray microtomography are discussed. Although heterogeneous, these preliminary results demonstrate that in vivo bioprinting is possible. Bioprinting may prove to be helpful in the future for medical robotics and computer-assisted medical interventions.
Synthesis and preliminary biodistribution studies of [131I]SIB-PEG4-CHC in tumor-bearing mice
International Nuclear Information System (INIS)
Xiaobei Zheng; Jing Yang; Xiaojiang Duan; Tingting Niu; Wangsuo Wu; Jianjun Wang; Feng Dong
2011-01-01
This work reports the synthesis and preliminary biodistribution results of [ 131 I]SIB-PEG 4 -CHC in tumor-bearing mice. The tributylstannyl precursor ATE-PEG 4 -CHC was synthesized by conjugation of ATE to amino pegylated colchicine NH 2 -PEG 4 -CHC. [ 131 I]SIB-PEG 4 -CHC was radiosynthesized by electrophilic destannylation of the precursor with a yield of ∼44%. The radiochemical purity (RCP) appeared to be >95% by a Sep-Pak cartridge purification. [ 131 I]SIB-PEG 4 -CHC was lipophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [ 131 I]SIB-PEG 4 -CHC cleared from background rapidly, and didn't deiodinate in vivo. However, the poor tumor localization excluded it from further investigations as a tumor-targeted radiopharmaceuticals. (author)
New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results.
Madelmont, J C; Godeneche, D; Parry, D; Duprat, J; Chabard, J L; Plagne, R; Mathe, G; Meyniel, G
1985-09-01
Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
Radiolabelling of RC-160: preliminary results
International Nuclear Information System (INIS)
Verdera, E.S.; Balter Binsky, H.S.; Robles, A.M.; Rodriguez, G.; Souto, B.; Laiz, J.; Oliver, P.; Leon, E.
1998-01-01
Vapreotide (RC-160) was labelled with 125 I using Chloramine-T and Iodogen methods and with 99m Tc by a direct method with sodium ditionite as reducing agent in the presence of ascorbic acid. Several methods of purification and quality control were evaluated. Yields of the reactions and of purification steps were calculated. The results obtained for the radioiodination reactions showed higher yields when limiting Chloramine-T method was used. Labelling of RC-160 with 99m Tc indicated better yields when high radioactivity concentration of the radionuclide was used. Stability of the products obtained was assessed at different post-labelling times by selected quality control methods: Sep-Pak cartridge as purification method and chromatography by RP-HPLC and ITLC-SG using saline solution as solvent. It was demonstrated that I-125-RC-160 and Tc-99m-RC-160 were stable during five weeks (at -20 deg. C) and 6 hours (at room temperature) respectively. Preliminary biodistribution of Tc-99m-RC-160 in normal rats and mice were done showing different biological behaviour compared with control animals injected with pertechnetate. In conclusion, RC-160 was successfully labelled with both radionuclides, with radiochemical purity higher than 95%. These results encourage further research work in animal models as well as to investigate the biochemical behaviour of radiolabelled peptide. (author)
Life span studies on mice exposed to heavy charged particles or photons: preliminary results
International Nuclear Information System (INIS)
Ainsworth, E.J.
1980-01-01
This chapter summarizes the results currently available where dose-dependent mortality is compared among the single cohort that received fractionated doses of carbon ions and the first replicate that received single doses. At this time, 17% mortality has occurred in both groups and had enhanced life shortening been produced by fractionation of the carbon ion dose, somewhat higher mortality might be expected. Cautious interpretation of these preliminary results is necessary, but the mortality data available at this time provides no evidence for enhancement by dose fractionation with carbon ions. In sum, at this time, it appears the Q factor used for fission spectrum neutrons could be conservative if it were used for assessment of risk following exposure to 400 MeV carbon ions
Ayanwuyi, Lydia O.; Kwanashie, Helen O.; Hussaini, Isa M.; Yaro, Abdullahi H.
2016-01-01
Background: Leonotis nepetifolia Linn (Lamiaceae) is used in traditional medicine for its calming (tranquilizing) effects. The aim of this study was to determine whether there is any scientific justification for this use. To achieve this purpose, we investigated the behavioural effects of the methanol extract of Leonotis nepetifolia stem (37.5, 75 and 150 mg/kg) in mice. Methods: Acute toxicity studies were carried out on the methanol stem extract of Leonotis nepetifolia to determine the LD50. The behavioural tests employed were diazepam-induced sleep onset and duration, hole board assay for exploratory activity, mouse beam walk assay for motor coordination, and the staircase test for the detection of anxiolytic compounds. Preliminary phytochemical screening was also carried out on the extract. Results: The intraperitoneal LD50 value was found to be 3.8 g/kg. The results showed that the extract significantly prolonged the duration of diazepam-induced sleep at the highest dose (150 mg/kg). There was no observable effect on exploratory activity and motor coordination at the doses tested (37.5, 75 and 150 mg/kg). The extract, however, at 150 mg/kg elicited a significant decrease in the number of rearings in the staircase test, an effect also observed in the group of mice injected with an anxiolytic dose of diazepam. The preliminary phytochemical screening revealed the presence of alkaloids, saponins, glycosides and triterpenoids. Conclusion: The results obtained suggest that the crude methanol extract of Leonotis nepetifolia stem possesses some biologically active constituents with potential anxiolytic activity and thus may justify its traditional use as a tranquilizer. PMID:28852715
Cell emulation and preliminary results.
2016-07-01
This report details preliminary results of the testing plan implemented by the Hawaii Natural Energy Institute to evaluate Electric Vehicle (EV) battery durability and reliability under electric utility grid operations. Commercial EV battery cells ar...
Antares: preliminary demonstrator results
International Nuclear Information System (INIS)
Kouchner, A.
2000-05-01
The ANTARES collaboration is building an undersea neutrino telescope off Toulon (Mediterranean sea) with effective area ∼ 0.1 km 2 . An extensive study of the site properties has been achieved together with software analysis in order to optimize the performance of the detector. Results are summarized here. An instrumented line, linked to shore for first time via an electro-optical cable, has been immersed late 1999. The preliminary results of this demonstrator line are reported. (author)
Directory of Open Access Journals (Sweden)
Aron Baumann
2016-11-01
Full Text Available Apathy is considered to be a core feature of Parkinson’s disease (PD and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction, and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out. In the context of PD only a few studies on toxin-based models (i.e. 6-OHDA or MPTP claimed to have determined apathetic symptoms in animals. The assessment of apathetic symptoms in more elaborated and multifaceted genetic animal models of PD could help to understand the pathophysiological development of apathy in PD and eventually advance specific treatments for afflicted patients. Here we report the presence of behavioral signs of apathy in 12 months old mice that express only ~5% of the vesicular monoamine transporter 2 (VMAT2. Apathetic-like behavior in VMAT2 deficient (LO mice was evidenced by impaired burrowing and nest building skills, and a reduced preference for sweet solution in the saccharin preference test, while the performance in the forced swimming test was normal. Our preliminary results suggest that VMAT2 deficient mice show an apathetic-like phenotype that might be independent of depressive-like symptoms. Therefore VMAT2 LO mice could be a useful tool to study of the pathophysiological substrates of apathy and to test novel treatment strategies for apathy in the context of PD.
Evaluating fatigue in lupus-prone mice: preliminary assessments.
Meeks, Allison; Larson, Susan J
2012-01-01
Fatigue is a debilitating condition suffered by many as the result of chronic disease, yet relatively little is known about its biological basis or how to effectively manage its effects. This study sought to evaluate chronic fatigue by using lupus-prone mice and testing them at three different time periods. Lupus-prone mice were chosen because fatigue affects over half of patients with Systemic Lupus Erythematosus. Eleven MLR⁺/(+) (genetic controls) and twelve MLR/MpJ-Fas/J (MRL/lpr; lupus-prone) mice were tested three times: once at 12, 16 and 20 weeks of age. All mice were subjected to a variety of behavioral tests including: forced swim, post-swim grooming, running wheel, and sucrose consumption; five of the MLR⁺/(+) and five of the MLR/lpr mice were also tested on a fixed ratio-25 operant conditioning task. MRL/lpr mice showed more peripheral symptoms of lupus than controls, particularly lymphadenopathy and proteinuria. Lupus mice spent more time floating during the forced swim test and traveled less distance in the running wheel at each testing period. There were no differences between groups in post-swim grooming or in number of reinforcers earned in the operant conditioning task indicating the behavioral changes were not likely due simply to muscle weakness or motivation. Correlations between performance in the running wheel, forced swim test and sucrose consumption were conducted and distance traveled in the running wheel was consistently negatively correlated with time spent floating. Based on these data, we conclude that the lupus-prone mice were experiencing chronic fatigue and that running wheel activity and floating during a forced swim test can be used to evaluate fatigue, although these data cannot rule out the possibility that both fatigue and a depressive-like state were mediating these effects. Copyright © 2011 Elsevier Inc. All rights reserved.
Directory of Open Access Journals (Sweden)
Arianna B Lovati
Full Text Available BACKGROUND: Implant-related infections are characterized by bacterial colonization and biofilm formation on the prosthesis. Diabetes represents one of the risk factors that increase the chances of prosthetic infections because of related severe peripheral vascular disease. Vasodilatation can be a therapeutic option to overcome diabetic vascular damages and increase the local blood supply. In this study, the effect of a PGE₁ vasodilator on the incidence of surgical infections in diabetic mice was investigated. METHODOLOGY: A S. aureus implant-related infection was induced in femurs of diabetic mice, then differently treated with a third generation cephalosporin alone or associated with a PGE₁ vasodilator. Variations in mouse body weight were evaluated as index of animal welfare. The femurs were harvested after 28 days and underwent both qualitative and quantitative analysis as micro-CT, histological and microbiological analyses. RESULTS: The analysis performed in this study demonstrated the increased host response to implant-related infection in diabetic mice treated with the combination of a PGE₁ and antibiotic. In this group, restrained signs of infections were identified by micro-CT and histological analysis. On the other hand, the diabetic mice treated with the antibiotic alone showed a severe infection and inability to successfully respond to the standard antimicrobial treatment. CONCLUSIONS: The present study revealed interesting preliminary results in the use of a drug combination of antibiotic and vasodilator to prevent implant-related Staphylococcus aureus infections in a diabetic mouse model.
Preliminary results of steel containment vessel model test
International Nuclear Information System (INIS)
Matsumoto, T.; Komine, K.; Arai, S.
1997-01-01
A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11-12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented
Lovati, Arianna B; Romanò, Carlo L; Monti, Lorenzo; Vassena, Christian; Previdi, Sara; Drago, Lorenzo
2014-01-01
Implant-related infections are characterized by bacterial colonization and biofilm formation on the prosthesis. Diabetes represents one of the risk factors that increase the chances of prosthetic infections because of related severe peripheral vascular disease. Vasodilatation can be a therapeutic option to overcome diabetic vascular damages and increase the local blood supply. In this study, the effect of a PGE₁ vasodilator on the incidence of surgical infections in diabetic mice was investigated. A S. aureus implant-related infection was induced in femurs of diabetic mice, then differently treated with a third generation cephalosporin alone or associated with a PGE₁ vasodilator. Variations in mouse body weight were evaluated as index of animal welfare. The femurs were harvested after 28 days and underwent both qualitative and quantitative analysis as micro-CT, histological and microbiological analyses. The analysis performed in this study demonstrated the increased host response to implant-related infection in diabetic mice treated with the combination of a PGE₁ and antibiotic. In this group, restrained signs of infections were identified by micro-CT and histological analysis. On the other hand, the diabetic mice treated with the antibiotic alone showed a severe infection and inability to successfully respond to the standard antimicrobial treatment. The present study revealed interesting preliminary results in the use of a drug combination of antibiotic and vasodilator to prevent implant-related Staphylococcus aureus infections in a diabetic mouse model.
Lovati, Arianna B.; Romanò, Carlo L.; Monti, Lorenzo; Vassena, Christian; Previdi, Sara; Drago, Lorenzo
2014-01-01
Background Implant-related infections are characterized by bacterial colonization and biofilm formation on the prosthesis. Diabetes represents one of the risk factors that increase the chances of prosthetic infections because of related severe peripheral vascular disease. Vasodilatation can be a therapeutic option to overcome diabetic vascular damages and increase the local blood supply. In this study, the effect of a PGE1 vasodilator on the incidence of surgical infections in diabetic mice was investigated. Methodology A S. aureus implant-related infection was induced in femurs of diabetic mice, then differently treated with a third generation cephalosporin alone or associated with a PGE1 vasodilator. Variations in mouse body weight were evaluated as index of animal welfare. The femurs were harvested after 28 days and underwent both qualitative and quantitative analysis as micro-CT, histological and microbiological analyses. Results The analysis performed in this study demonstrated the increased host response to implant-related infection in diabetic mice treated with the combination of a PGE1 and antibiotic. In this group, restrained signs of infections were identified by micro-CT and histological analysis. On the other hand, the diabetic mice treated with the antibiotic alone showed a severe infection and inability to successfully respond to the standard antimicrobial treatment. Conclusions The present study revealed interesting preliminary results in the use of a drug combination of antibiotic and vasodilator to prevent implant-related Staphylococcus aureus infections in a diabetic mouse model. PMID:24718359
Preliminary results from NOAMP deep drifting floats
International Nuclear Information System (INIS)
Ollitrault, M.
1989-01-01
This paper is a very brief and preliminary outline of first results obtained with deep SOFAR floats in the NOAMP area. The work is now going toward more precise statistical estimations of mean and variable currents, together with better tracking to resolve submesoscales and estimate diffusivities due to mesoscale and smaller scale motions. However the preliminary results confirm that the NOAMP region (and surroundings) has a deep mesoscale eddy field that is considerably more energetic that the mean field (r.m.s. velocities are of order 5 cm s -1 ), although both values are diminished compared to the western basin. A data report containing trajectories and statistics is scheduled to be published by IFREMER in the near future. The project main task is to especially study the dispersion of radioactive substances
The friction of polymers around Tg,Tm : Preliminary results
DEFF Research Database (Denmark)
Sivebæk, Ion Marius; Samoilov, V N; Persson, B N J
We present Molecular Dynamics calculations involving polymers of different lengths. Polymers with lengths from 20 to 1400 carbon atoms are considered. The systems are able to simulate friction between polymer surfaces and polymer against metal. The results we present are very preliminary and they......We present Molecular Dynamics calculations involving polymers of different lengths. Polymers with lengths from 20 to 1400 carbon atoms are considered. The systems are able to simulate friction between polymer surfaces and polymer against metal. The results we present are very preliminary...
French 900 MWe PWR PSA preliminary results
International Nuclear Information System (INIS)
Lanore, J.M.; Brisbois, J.
1988-10-01
A PSA is performed by the Safety Assessment Department of CEA for a 900 MWe standardized plant. The paper presents the objectives, the scope of the study and the relative preliminary results. Some general insights are drawn, especially the benefit related to the implementation of emergency procedures
Danish Anaesthesia Allergy Centre - preliminary results
DEFF Research Database (Denmark)
Garvey, L H; Roed-Petersen, J; Menné, T
2001-01-01
BACKGROUND: Anaphylactoid reactions in anaesthesia are rare and should ideally be investigated in specialist centres. At Gentofte University Hospital, we established such a centre in 1998 as a joint venture between the Departments of Anaesthesiology and Dermatology. We present the methodology...... for chlorhexidine. Only one patient has tested positive to a neuromuscular blocking drug (NMBD) so far. DISCUSSION: Our preliminary results appear to differ in two ways from results usually found in this field. Firstly, only one patient has tested positive for a NMBD and secondly, we have had four patients...
Preliminary results from the hierarchical glitch pipeline
International Nuclear Information System (INIS)
Mukherjee, Soma
2007-01-01
This paper reports on the preliminary results obtained from the hierarchical glitch classification pipeline on LIGO data. The pipeline that has been under construction for the past year is now complete and end-to-end tested. It is ready to generate analysis results on a daily basis. The details of the pipeline, the classification algorithms employed and the results obtained with one days analysis on the gravitational wave and several auxiliary and environmental channels from all three LIGO detectors are discussed
Cognitive Task Analysis of Business Jet Pilots' Weather Flying Behaviors: Preliminary Results
Latorella, Kara; Pliske, Rebecca; Hutton, Robert; Chrenka, Jason
2001-01-01
This report presents preliminary findings from a cognitive task analysis (CTA) of business aviation piloting. Results describe challenging weather-related aviation decisions and the information and cues used to support these decisions. Further, these results demonstrate the role of expertise in business aviation decision-making in weather flying, and how weather information is acquired and assessed for reliability. The challenging weather scenarios and novice errors identified in the results provide the basis for experimental scenarios and dependent measures to be used in future flight simulation evaluations of candidate aviation weather information systems. Finally, we analyzed these preliminary results to recommend design and training interventions to improve business aviation decision-making with weather information. The primary objective of this report is to present these preliminary findings and to document the extended CTA methodology used to elicit and represent expert business aviator decision-making with weather information. These preliminary findings will be augmented with results from additional subjects using this methodology. A summary of the complete results, absent the detailed treatment of methodology provided in this report, will be documented in a separate publication.
Preliminary Cluster Size and Efficiencies results of CMS RPC at GIF++
Gonzalez Blanco Gonzalez, Genoveva
2016-01-01
A brief description and first preliminary results of the Efficiencies and Cluster Size measurements of the CMS Resistive Plate Chambers, will be presented inside the Gamma Irradiation Facility GIF++ at CERN. Preliminary studies that sets the base performance measurements of CMS RPC for starting aging studies.
International Nuclear Information System (INIS)
Rutgers, D.H.
1988-01-01
A Cs-137 afterloading technique is described which can be used in experimental tumours. Preliminary results, obtained with the human cervical carcinoma ME-180 xenografted to nude athymic mice, demonstrated that 20 Gy of low dose-rate irradiation induced an important redistribution of cells over cell cycle. The proportion of cells in G2-phase increased from 14.4% to 44.2% at 140 hours after irradiation. This method allows an accurate calculation of the dose-rate distribution in the tumour. Investigations of the cell kinetic effects of low dose-rate irradiation, at different dose-rates and different total doses, are therefore facilitated by the technique. (orig.) [de
Preliminary results on heavy flavor physics at SLD
Energy Technology Data Exchange (ETDEWEB)
Usher, T. [Stanford Univ., CA (United States)
1994-12-01
The author reports on preliminary heavy flavor physics results from the SLD detector at the SLAC Linear Collider. Efficient tagging of b{bar b} events is achieved with an impact parameter technique that takes advantage of the small and stable interaction point of the SLC and all charged tracks in Z{sup 0} decays. This technique is applied to samples of Z{sup 0} events collected during the 1992 and 1993 physics runs. Preliminary measurements of the ratio R{sub b} = {Gamma}(Z{sup 0} {yields} b{bar b})/{Gamma}(Z{sup 0} {yields} hadrons) and the average B hadron lifetime <{tau}{sub B}> are reported. In a sample of 27K Z{sup 0} events, values of R{sub b} = 0.235 {+-} 0.006(stat.) {+-} 0.018(syst.) and <{tau}{sub B}> = 1.53 {+-} 0.006(stat.) {+-} 0.018(syst.) are obtained. In addition, the first measurement of the left-right asymmetry A{sub b} is reported. Using a sample of 38K Z{sup 0} events with a luminosity weighted electron polarization of 62%, the author obtains a preliminary value of A{sub b} = 0.94 {+-} 0.006(stat.) {+-} 0.018(syst.).
Preliminary results from film boiling destabilisation experiments
International Nuclear Information System (INIS)
Naylor, P.
1984-05-01
A series of experiments to investigate the triggered destabilisation of film boiling has been undertaken. Film boiling was established on a polished brass rod immersed in water and the effects of various triggers were investigated. Preliminary results are presented and two thresholds have been observed: an impulse threshold below which triggered destabilisation will not occur and a thermal threshold above which film boiling will re-establish following triggered destabilisation. (author)
Iron in hereditary retinal degeneration: PIXE microanalysis Preliminary results
International Nuclear Information System (INIS)
Sergeant, C.; Gouget, B.; Llabador, Y.; Simonoff, M.; Yefimova, M.; Courtois, Y.; Jeanny, J.C.
1999-01-01
Several types of hereditary retinal degeneration with progressive alteration of photoreceptors exist in men and animals. Recent immunohistochemical results have shown strong degradation of transferrin, the protein responsible for iron transport, in retinas of rats with hereditary retinal degeneration. Freeze-dried thin sections of rat retinas from different stages of the disease, and respective coeval control sections, have been analyzed using nuclear microprobe. In this first part of the study, the rat retinas at post-natal stages of 35 and 45 days have been analyzed. The sample preparation and the post-irradiation staining to determine precisely the retinal layers involved are described. Preliminary results of element distributions (K, Ca, Fe) in the rat retina layers are discussed. A very high content of calcium in the choriocapillaris of dystrophic rat retinas was observed. Preliminary results on iron distribution in the rat retina layers are presented
Preliminary results of the Adone storage ring FEL experiment, LELA
International Nuclear Information System (INIS)
Barbini, R.; Vignola, G.; Trillo, S.
1983-01-01
A short description of the LELA (Free Electron Laser on Adone) experiment is given. Results on the spontaneous radiation angle and energy spectra and preliminary results on optical gain measurements are also discussed
Preliminary results of testing bioassay analytical performance standards
International Nuclear Information System (INIS)
Fisher, D.R.; Robinson, A.V.; Hadley, R.T.
1983-08-01
The analytical performance of both in vivo and in vitro bioassay laboratories is being studied to determine the capability of these laboratories to meet the minimum criteria for accuracy and precision specified in the draft ANSI Standard N13.30, Performance Criteria for Radiobioassay. This paper presents preliminary results of the first round of testing
Preliminary test results from a telescope of Hughes pixel arrays at FNAL
International Nuclear Information System (INIS)
Jernigan, J.G.; Arens, J.; Vezie, D.; Collins, T.; Krider, J.; Skubic, P.
1992-09-01
In December of 1991 three silicon hybrid pixel detectors each having 2.56 x 2.56 pixels 30 μm square, made by the Hughes Aircraft Company, were placed in a high energy muon beam at the Fermi National Accelerator Laboratory. Straight tracks were recorded in these detectors at angles to the normal to the plane of the silicon ranging from 0 to 45 degrees. In this note, preliminary results are presented on the straight through tracks, i.e., those passing through the telescope at normal incidence. Pulse height data, signal-to-noise data, and preliminary straight line fits to the data resulting in residual distributions are presented. Preliminary calculations show spatial resolution of less than 5 μm in two dimensions
Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results
Energy Technology Data Exchange (ETDEWEB)
Chandler, K.; Eudy, L.
2008-10-01
This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.
Preliminary results of a PWA of the centrally produced {phi}{phi} system
Energy Technology Data Exchange (ETDEWEB)
Marco A. Reyes et al.
2001-11-02
The authors present preliminary results of a Partial Wave Analysis of the centrally produced {phi}{phi} system at 800 GeV/c in the reaction pp {yields} p{sub slow} ({phi}{phi})p{sub fast}. The preliminary results with one and two M = 0 waves, indicate that most of the cross section can be described by two waves, with J{sup PC} LS{sup {eta}} = 2{sup 2}02{sup -1}, 0{sup 2}00{sup -1}.
Some effects of irradiation of mice in utero with tritiated compounds
Energy Technology Data Exchange (ETDEWEB)
Lambert, B E; Phipps, M L [Radiobiology Department, The Medical College of Bartholomew' s Hospital, London, UK
1978-01-01
Mice have been exposed continuously, in utero, to tritiated water (via the maternal drinking water) or to tritiated thymidine (infused continuously into the mother). In both cases the patterns of labeling and subsequent loss of tritium over an extended period have been studied. The technique of infusion in unrestrained mice and its application in the production of fully tritium-labeled offspring is described in some detail. These fully labeled mice are being used to study a number of early and late effects, in particular, gonad cell effects and carcinogenesis, following this form of internal irradiation. Some preliminary results are presented. Similar results produced by homogeneous irradiation from tritiated water are also reported.
Some effects of irradiation of mice in utero with tritiated compounds
International Nuclear Information System (INIS)
Lambert, B.E.; Phipps, M.L.
1978-01-01
Mice have been exposed continuously, in utero, to tritiated water (via the maternal drinking water) or to tritiated thymidine (infused continuously into the mother). In both cases the patterns of labeling and subsequent loss of tritium over an extended period have been studied. The technique of infusion in unrestrained mice and its application in the production of fully tritium-labeled offspring is described in some detail. These fully labeled mice are being used to study a number of early and late effects, in particular, gonad cell effects and carcinogenesis, following this form of internal irradiation. Some preliminary results are presented. Similar results produced by homogeneous irradiation from tritiated water are also reported. (Auth.)
Danish Anaesthesia Allergy Centre - preliminary results
DEFF Research Database (Denmark)
Garvey, L H; Roed-Petersen, J; Menné, T
2001-01-01
BACKGROUND: Anaphylactoid reactions in anaesthesia are rare and should ideally be investigated in specialist centres. At Gentofte University Hospital, we established such a centre in 1998 as a joint venture between the Departments of Anaesthesiology and Dermatology. We present the methodology...... of in vitro testing and skin testing. Blood samples for tryptase analysis are taken at the time of reaction and a control sample is taken together with samples for specific IgE analysis 2-4 weeks after the reaction. Subsequent skin testing comprises both prick tests and intradermal tests in most cases...... for chlorhexidine. Only one patient has tested positive to a neuromuscular blocking drug (NMBD) so far. DISCUSSION: Our preliminary results appear to differ in two ways from results usually found in this field. Firstly, only one patient has tested positive for a NMBD and secondly, we have had four patients...
King County Metro Battery Electric Bus Demonstration: Preliminary Project Results
Energy Technology Data Exchange (ETDEWEB)
2017-05-22
The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing next generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.
Structural investigations of biogenic iron oxide samples. Preliminary results
International Nuclear Information System (INIS)
Balasoiu, M.; Kuklin, A.I.; Orelovich, O.L.; Kovalev, Yu.S.; Arzumanyan, G.M.; Kurkin, T.S.; Stolyar, S.V.; Iskhakov, R.S.; Rajkher, Yu.L.
2008-01-01
Some preliminary results on morphology and structure of iron oxide particles formed inside Klebsiella oxytoca bacteria are presented. In particular, by means of optical microscopy, scanning electron microscopy and small-angle X-ray scattering the effect of the bacteria age (the duration of growth) on the nanoparticles properties is studied
Normal Conducting RF Cavity for MICE
International Nuclear Information System (INIS)
Li, D.; DeMello, A.; Virostek, S.; Zisman, M.; Summers, D.
2010-01-01
Normal conducting RF cavities must be used for the cooling section of the international Muon Ionization Cooling Experiment (MICE), currently under construction at Rutherford Appleton Laboratory (RAL) in the UK. Eight 201-MHz cavities are needed for the MICE cooling section; fabrication of the first five cavities is complete. We report the cavity fabrication status including cavity design, fabrication techniques and preliminary low power RF measurements.
Remote sensing using hydroacoustics preliminary results
International Nuclear Information System (INIS)
Hunt, G.; Patrick, P.H.; Sim, B.
1989-01-01
A laboratory investigation was conducted to determine the capability and accuracy of a dual beam sonar system in classifying various targets. The ability to classify fish and/or distinguish fish from debris is essential if hydroacoustics are ever to be used truly remotely for hydroelectric power plant fish passage facilities. Preliminary results indicated that considerable filtering was occurring in the sonar sounder which limited its use in target classification. A wideband sonar detection module was developed which allowed for a more detailed reflected signal which probably will be necessary for fish identification. Another advantage that this modification appears to have over the existing system is an improved spatial resolution of targets, which can be significant if biomass estimates are based on echo counting techniques rather than echo integration ones. Based on the results, it may be possible to filter out or remove the influence of air bubbles in echo returns. As a result echo counts could more accurately be defined as fish counts. Target strengths of sturgeon were estimated using both the modified and original sounder. 12 refs., 11 figs., 2 tabs
Preliminary results of statistical dynamic experiments on a heat exchanger
International Nuclear Information System (INIS)
Corran, E.R.; Cummins, J.D.
1962-10-01
The inherent noise signals present in a heat exchanger have been recorded and analysed in order to determine some of the statistical dynamic characteristics of the heat exchanger. These preliminary results show that the primary side temperature frequency response may be determined by analysing the inherent noise. The secondary side temperature frequency response and cross coupled temperature frequency responses between primary and secondary are poorly determined because of the presence of a non-stationary noise source in the secondary circuit of this heat exchanger. This may be overcome by correlating the dependent variables with an externally applied noise signal. Some preliminary experiments with an externally applied random telegraph type of signal are reported. (author)
Preliminary result and upgrade from WISPDMX Phase II
Energy Technology Data Exchange (ETDEWEB)
Nguyen, Le Hoang; Horns, Dieter [Institut fur Experimentalphysik, Universitat Hamburg (Germany); Lobanov, Andrei [Institut fur Experimentalphysik, Universitat Hamburg (Germany); Max-Planck-Institut fur Radioastronomie, Bonn (Germany)
2016-07-01
The microwave cavity experiment WISPDMX is the first direct WISP (Weakly interactive slim particles) dark matter search experiment probing the particle masses in the 0.8-2.0 eV range. The first stage of WISPDMX measurements has been completed at nominal resonant frequencies of the cavity. The upgrading of the data acquisition and analysing has been done to increase the sensitivity of the experiment. We report preliminary result from the cavity tuning at second stage of WISPDMX.
1ST-TRIMESTER SCREENING FOR FETAL CHROMOSOMAL-ABNORMALITIES - PRELIMINARY-RESULTS
VANLITH, JMM
We have started a multicentre trial to study the possibilities of first-trimester maternal serum screening for fetal chromosomal abnormalities. Maternal blood samples were obtained before 13 weeks of gestation. We present the preliminary results of the first 950 patients on alpha-fetoprotein (AFP).
Preliminary results of neutron production in Sahand plasma focus device
International Nuclear Information System (INIS)
Siahpoush, V.; Mohammadi, M.A.; Khorram, S.; Shabani, I.; Borhanian, J.; Ashrafi, S.; Naghshara, H.; Moslehi-Fard, M.; Sobhanian, S.
2004-01-01
We report in this paper the preliminary results of neutron generation during fusion reaction in deuterium in the Sahand Filipov type plasma focus, recently installed and put in operation at Tabriz University. The special calibration procedure for neutron detection system, using activation method is described
Preliminary Results of the Louisiana Sex Offender Treatment Program
Directory of Open Access Journals (Sweden)
Lee A. Underwood
2015-12-01
Full Text Available The purpose of this study was to offer preliminary support for the Louisiana Sex Offender Treatment Program (LSOTP in addressing the needs of juvenile sex offenders. Research objectives were (1 to offer statistical evidence for reductions in anxiety, depression, cognitive distortion and negative attitudes towards women comparing a group of 21 adolescents, 12 of whom received services as usual and nine of whom participated in the LSOTP. A controlled experimental evaluation design was utilized. The juvenile sex offenders were randomly assigned to the experimental group for 12 weeks receiving treatment services and a control group receiving care “as usual” in a residential group care program. Participants in the experimental group experienced statistically significant decreases in cognitive distortions related specifically to rape and molestation.The results of this study offer preliminary support of the LSOTP as a best practices alternative to other treatment modalities.
Trade-off results and preliminary designs of Near-Term Hybrid Vehicles
Sandberg, J. J.
1980-01-01
Phase I of the Near-Term Hybrid Vehicle Program involved the development of preliminary designs of electric/heat engine hybrid passenger vehicles. The preliminary designs were developed on the basis of mission analysis, performance specification, and design trade-off studies conducted independently by four contractors. THe resulting designs involve parallel hybrid (heat engine/electric) propulsion systems with significant variation in component selection, power train layout, and control strategy. Each of the four designs is projected by its developer as having the potential to substitute electrical energy for 40% to 70% of the petroleum fuel consumed annually by its conventional counterpart.
Preliminary test results for post irradiation examination on the HTTR fuel
International Nuclear Information System (INIS)
Ueta, Shohei; Umeda, Masayuki; Sawa, Kazuhiro; Sozawa, Shizuo; Shimizu, Michio; Ishigaki, Yoshinobu; Obata, Hiroyuki
2007-01-01
The future post-irradiation program for the first-loading fuel of the HTTR is scheduled using the HTTR fuel handling facilities and the Hot Laboratory in the Japan Materials Testing Reactor (JMTR) to confirm its irradiation resistance and to obtain data on its irradiation characteristics in the core. This report describes the preliminary test results and the future plan for a post-irradiation examination for the HTTR fuel. In the preliminary test, fuel compacts made with the same SiC-coated fuel particle as the first loading fuel were used. In the preliminary test, dimension, weight, fuel failure fraction, and burnup were measured, and X-ray radiograph, SEM, and EPMA observations were carried out. Finally, it was confirmed that the first-loading fuel of the HTTR showed good quality under an irradiation condition. The future plan for the post-irradiation tests was described to confirm its irradiation performance and to obtain data on its irradiation characteristics in the HTTR core. (author)
Preliminary results of an oilspill risk analysis for the Bombay High Region
Digital Repository Service at National Institute of Oceanography (India)
Mascarenhas, A.A.M.Q.; Gouveia, A.D.; Sitaraman, R.
oil were analysed, covering estimates of the time between spill occurrence and contact with resources. The combined results yielded estimates of the overall risks associated with production within the developmental area. Preliminary results...
Preliminary Results on Uncertainty Quantification for Pattern Analytics
Energy Technology Data Exchange (ETDEWEB)
Stracuzzi, David John [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Brost, Randolph [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chen, Maximillian Gene [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Malinas, Rebecca [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Peterson, Matthew Gregor [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Phillips, Cynthia A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Robinson, David G. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Woodbridge, Diane [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
2015-09-01
This report summarizes preliminary research into uncertainty quantification for pattern ana- lytics within the context of the Pattern Analytics to Support High-Performance Exploitation and Reasoning (PANTHER) project. The primary focus of PANTHER was to make large quantities of remote sensing data searchable by analysts. The work described in this re- port adds nuance to both the initial data preparation steps and the search process. Search queries are transformed from does the specified pattern exist in the data? to how certain is the system that the returned results match the query? We show example results for both data processing and search, and discuss a number of possible improvements for each.
Authentication by Keystroke Timing: Some Preliminary Results
National Research Council Canada - National Science Library
Gaines, R. S; Lisowski, William; Press, S. J; Shapiro, Norman
1980-01-01
... of an individual seeking access to the computer. This report summarizes preliminary efforts to establish whether an individual can be identified by the statistical characteristics of his or her typing...
Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice
Directory of Open Access Journals (Sweden)
Luis G. Rabaneda
2014-07-01
Full Text Available Autism spectrum disorders (ASDs comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated transgenic βNrx1ΔC mice in which neurexin function is selectively impaired during late postnatal stages. Whole-cell recordings in cortical neurons show an impairment of glutamatergic synaptic transmission in the βNrx1ΔC mice. Importantly, mutant mice exhibit autism-related symptoms, such as increased self-grooming, deficits in social interactions, and altered interaction for nonsocial olfactory cues. The autistic-like phenotype of βNrx1ΔC mice can be reversed after removing the mutant protein in aged animals. The defects resulting from disruption of neurexin function after the completion of embryonic and early postnatal development suggest that functional impairment of mature circuits can trigger autism-related phenotypes.
Preliminary Langmuir probe results on the CTX gun experiment
International Nuclear Information System (INIS)
Tuszewski, M.
1981-12-01
Preliminary results obtained with a double Langmuir probe in the Compact Toroid experiment facility confirm the existence of a gun plasma of n approx. 5 x 10 14 cm -3 and T approx. 10 eV lasting for approx. 250 to 400 μs, which is consistent with interferometry and Thomson scattering data. The probe current characteristics as a function of voltage suggest non-Maxwellian features of the particles distribution functions
Preliminary results of Digital Pulse Shape Acquisition from Chimera
International Nuclear Information System (INIS)
Alderighi, D.M.; Sechi, G.; Anzalone, A.; Cavallaro, S.; Giustolisi, F.; Laguidara, E.; Lanzalone, G.; Porto, F.; Bassini, R.; Boiano, C.; Guazzoni, P.; Russo, S.; Sassi, M.; Zetta, L.; Cardella, G.; Defilippo, S.E.; Lanzano, G.; Paganod, A.; Papa, M.; Pirrone, S.; Politi, G.; Geraci, E.
2003-01-01
A 100 MS/s 14-bit Sampling Analog-to-Digital converter has been used to perform digital pulse-shape acquisition of signals collected from CHIMERA telescopes. The signals from a typical CHIMERA detection cell have been collected using both a standard CHIMERA electronic chain up to the amplifier, and a very simple analog front end, basically reduced to the preamplifier. The preliminary on-beam results are presented. (authors)
Preliminary results of Digital Pulse Shape Acquisition from Chimera
Energy Technology Data Exchange (ETDEWEB)
Alderighi, D.M.; Sechi, G. [INFN Milano and IASF, CNR, Milano (France); Anzalone, A.; Cavallaro, S.; Giustolisi, F.; Laguidara, E.; Lanzalone, G.; Porto, F. [Catania Univ., LNS and Dipartimento di Fisica (France); Bassini, R.; Boiano, C.; Guazzoni, P.; Russo, S.; Sassi, M.; Zetta, L. [Milano Univ., INFN and Dipartimento di Fisica (Italy); Cardella, G.; Defilippo, S.E.; Lanzano, G.; Paganod, A.; Papa, M.; Pirrone, S.; Politi, G. [Catania Univ., INFN and Dipartimento di Fisica (Italy); Geraci, E. [Bologna Univ., INFN and Dipartimento di Fisica (Italy)
2003-07-01
A 100 MS/s 14-bit Sampling Analog-to-Digital converter has been used to perform digital pulse-shape acquisition of signals collected from CHIMERA telescopes. The signals from a typical CHIMERA detection cell have been collected using both a standard CHIMERA electronic chain up to the amplifier, and a very simple analog front end, basically reduced to the preamplifier. The preliminary on-beam results are presented. (authors)
Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010
Maravelias, G.
2011-01-01
Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.
Functional requirements regarding medical registries--preliminary results.
Oberbichler, Stefan; Hörbst, Alexander
2013-01-01
The term medical registry is used to reference tools and processes to support clinical or epidemiologic research or provide a data basis for decisions regarding health care policies. In spite of this wide range of applications the term registry and the functional requirements which a registry should support are not clearly defined. This work presents preliminary results of a literature review to discover functional requirements which form a registry. To extract these requirements a set of peer reviewed articles was collected. These set of articles was screened by using methods from qualitative research. Up to now most discovered functional requirements focus on data quality (e. g. prevent transcription error by conducting automatic domain checks).
Preliminary results of a test of a longitudinal phase-space monitor
International Nuclear Information System (INIS)
Kikutani, Eiji; Funakoshi, Yoshihiro; Kawamoto, Takashi; Mimashi, Toshihiro
1994-01-01
A prototype of a longitudinal phase-space monitor has been developed in TRISTAN Main Ring at KEK. The principle of the monitor and its basic components are explained. Also a result of a preliminary beam test is given. (author)
Preliminary Results on Asymptotic Stabilization of Hamiltonian Systems with Nonholonomic Constraints
Khennouf, H.; Canudas de Wit, C.; Schaft, A.J. van der
1995-01-01
This paper presents some preliminary results on asymptotic stabilization of nonholonomic mechanical systems using the Hamiltonian formulation proposed previously. Our work seeks to establish a general formulation for designing time-varying controllers for some mechanical system described in the
Preliminary Results Of A 600 Joules Small Plasma Focus Device
International Nuclear Information System (INIS)
Lee, S. H.; Yap, S. L.; Wong, C. S.
2009-01-01
Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.
2012-12-06
... Republic of China: Preliminary Results of Antidumping Duty Administrative Review and Preliminary Partial... conducting an administrative review of the antidumping duty order on glycine from the People's Republic of... covers one exporter of subject merchandise, Baoding Mantong Fine Chemistry Co. Ltd. (Baoding Mantong). We...
Preliminary results of the round-robin testing of F82H
Energy Technology Data Exchange (ETDEWEB)
Shiba, K.; Yamanouchi, N.; Tohyama, A.
1996-10-01
Preliminary results of metallurgical, physical and mechanical properties of low activation ferritic steel F82H (IEA heat) were obtained in the round-robin test in Japan. The properties of IEA heat F82H were almost the same as the original F82H.
Radon concentrations in Norwegian kindergartens: survey planning and preliminary results
International Nuclear Information System (INIS)
Birovljev, A.; Strand, T.; Heiberg, A.
1998-01-01
An extensive radon survey in Norwegian kindergartens and schools was started in early 1997; so far 2481 kindergartens were examined. Preliminary results of the first phase of the survey are presented in tabular and graphic form including, among others, the dependence of average radon concentration on the construction year of the kindergartens and on the age of the buildings. (A.K.)
Carr, Alexandria; Zenitsky, Gary; Crowther, Lawrence; Hadimani, Ravi; Anantharam, Vellareddy; Kanthasamy, Anumantha; Jiles, David
2014-03-01
Transcranial magnetic stimulation (TMS) is a non-invasive surgery-free tool used to stimulate the brain by time-varying magnetic fields. TMS is currently being investigated as a treatment for neurological disorders such as depression, Parkinson's disease and TBI. Before moving to human TMS/TBI trials, animal testing should be pursued to determine suitability and adverse effects. As an initial study, four healthy mice were treated with TMS at different power levels to determine short-term behavioral effects and set a control group baseline. The mouse's behavior was studied using the Rotorod test, which measures the animal's latency to fall off a rotating rod, and the Versamax test, which measures horizontal and vertical movement, and total distance traveled. The Rotorod test has shown for TMS power levels >=90% the mice begin to fall directly post-treatment. Similarly, the Versamax test has shown for power levels >=80% the mice are less mobile directly post-treatment. Versamax mobility was found to return to normal the day following treatment. These mice were housed in the facility for 4 months and the behavioral tests were repeated. Versamax results showed there was no significant variation in mobility indicating there are no long-term side effects of TMS treatment on the mice. This work was supported by the Barbara and James Palmer Endowment and the Carver Charitable Trust at the Department of Electrical and Computer Engineering, Iowa State University.
MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms.
Directory of Open Access Journals (Sweden)
Zhou Zhou
Full Text Available Autoimmune gastritis is an organ-specific autoimmune disease of the stomach associated with pernicious anemia. The previous work from us and other groups identified MCPIP1 as an essential factor controlling inflammation and immune homeostasis. MCPIP1(-/- developed severe anemia. However, the mechanisms underlying this phenotype remain unclear. In the present study, we found that MCPIP1 deficiency in mice resulted in severe anemia related to autoimmune mechanisms. Although MCPIP1 deficiency did not affect erythropoiesis per se, the erythropoiesis in MCPIP1(-/- bone marrow erythroblasts was significantly attenuated due to iron and vitamin B12 (VB12 deficiency, which was mainly resulted from autoimmunity-associated gastritis and parietal cell loss. Consistently, exogenous supplement of iron and VB12 greatly improved the anemia phenotype of MCPIP1(-/- mice. Finally, we have evidence suggesting that autoimmune hemolysis may also contribute to anemia phenotype of MCPIP1(-/- mice. Taken together, our study suggests that MCPIP1 deficiency in mice leads to the development of autoimmune gastritis and pernicious anemia. Thus, MCPIP1(-/- mice may be a good mouse model for investigating the pathogenesis of pernicious anemia and testing the efficacy of some potential drugs for treatment of this disease.
The Southern HII Region Discovery Survey: Preliminary Results
Shea, Jeanine; Wenger, Trey; Balser, Dana S.; Anderson, Loren D.; Armentrout, William P.; Bania, Thomas M.; Dawson, Joanne; Miller Dickey, John; Jordan, Christopher; McClure-Griffiths, Naomi M.
2017-01-01
HII regions are some of the brightest sources at radio frequencies in the Milky Way and are the sites of massive O and B-type star formation. They have relatively short (Bank Telescope. Candidate HII regions were selected from mid-infrared emission coincident with radio continuum emission, and confirmed as HII regions by the detection of radio recombination lines. Here we discuss the Southern HII Region Discovery Survey (SHRDS), a continuation of the HRDS using the Australia Telescope Compact Array over the Galactic longitude range 230 to 360 degrees. We have reduced and analyzed a small sub-set of the SHRDS sources and discuss preliminary results, including kinematic distances and metallicities.
Nb/NiCu bilayers in single and stacked superconductive tunnel junctions: preliminary results
International Nuclear Information System (INIS)
Pepe, G.P.; Ruotolo, A.; Parlato, L.; Peluso, G.; Ausanio, G.; Carapella, G.; Latempa, R.
2004-01-01
We present preliminary experimental results concerning both single and stacked tunnel junctions in which one of the electrodes was formed by a superconductor/ferromagnet (S/F) bi-layer. In particular, in the stacked configuration a Nb/NiCu bi-layer was used as the intermediate electrode, and it was probed by tunneling on both sides. Tunnel junctions have been characterized in terms of current-voltage characteristics (IVC), and differential conductance. Preliminary steady-state injection-detection measurements performed in the stacked devices at T=4.2 K are also presented and discussed
Long range radio tracking of sea turtles and polar bear: Instrumentation and preliminary results
Baldwin, H. A.
1972-01-01
Instrumentation developed for studies of path behavior of the green sea turtle and migration movement of polar bear is described. Preliminary results bearing on navigation ability in these species are presented. Both species operate in difficult environments, and the problems faced in the design of electronic instrumentation for these studies are not completely specified at this time. However, the critical factors yet to be understood are primarily related to the behavior of instrumented animals. The data obtained with these experimental techniques are included, first to illustrate the technique and, second to provide initial preliminary results bearing on animal navigation.
Sedimentation on the Valencia Continental Shelf: Preliminary results
Maldonado, Andres; Swift, Donald J. P.; Young, Robert A.; Han, Gregory; Nittrouer, Charles A.; DeMaster, David J.; Rey, Jorge; Palomo, Carlos; Acosta, Juan; Ballester, A.; Castellvi, J.
1983-10-01
Preliminary analysis of data collected during the course of a cooperative Spanish-United States investigation of the Valencia Shelf (western Mediterranean) reveals a storm-dominated, mud-accumulating sedimentary regime. Calcareous mud is accumulating seaward of a narrow band of shoreface sand and gravel. On the outer shelf the mud is enriched by a pelagic calcareous component. Preliminary 210Pb data from vertical profiles of box cores yield nominal accumulation rates from 2.6 mm y -1 near the Ebro Delta to 1.3 mm y -1 on the southern portion of the Valencia Shelf. Storm-current winnowing has resulted in the development of a biogenic lag sand over the mid-shelf mud in the northern part of the study area. Piston cores reveal a basal Holocene sand and gravel facies similar to that presently seen on the inner shelf. Upward-fining sequences on the central and outer shelf are inferred to result from the landward shift of lithotopes during the course of the Holocene transgression. These sequences are locally repeated, perhaps as the consequence of brief, local interludes of coastal progradation. Application of a diagnostic circulation model suggests that intense, downwelling coastal flows occur during winter northeastern storms. Storm activity has induced erosional shoreface retreat during the course of the Holocene transgression and has generated by this means the basal coarse facies observed in the piston cores. In the central part of the study area seaward of the Albufera Lagoon, the mud blanket thins to a layer several centimeters thick which is draped over a thickened (10 m) basal sand. The basal sand is molded into northwest trending ridges. The data are not sufficient to determine whether these are overstepped barriers, or submarine sand ridges formed by storm flows during the shoreface retreat process.
BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice.
Zencak, Dusan; Crippa, Sylvain V; Tekaya, Meriem; Tanger, Ellen; Schorderet, Daniel E; Munier, Francis L; van Lohuizen, Maarten; Arsenijevic, Yvan
2006-01-01
Retinitis pigmentosa (RP) is a heterogeneous group of genetic disorders leading to blindness, which remain untreatable at present. Rd1 mice represent a recognized model of RP, and so far only GDNF treatment provided a slight delay in the retinal degeneration in these mice. Bmi1, a transcriptional repressor, has recently been shown to be essential for neural stem cell (NSC) renewal in the brain, with an increased appearance of glial cells in vivo in Bmi1 knockout (Bmi1-/-) mice. One of the roles of glial cells is to sustain neuronal function and survival. In the view of a role of the retinal Miller glia as a source of neural protection in the retina, the increased astrocytic population in the Bmi1-/- brain led us to investigate the effect of Bmi1 loss in Rd1 mice. We observed an increase of Müller glial cells in Rd1-Bmi1-/- retinas compared to Rd1. Moreover, Rd1-Bmi1-/- mice showed 7-8 rows of photoreceptors at 30 days of age (P30), while in Rd1 littermates there was a complete disruption of the outer nuclear layer (ONL). Preliminary ERG results showed a responsiveness of Rd1-Bmi1-/- mice in scotopic vision at P35. In conclusion, Bmi1 loss prevented, or rescued, photoreceptors from degeneration to an unanticipated extent in Rd1 mice. In this chapter, we will first provide a brief review of our work on the cortical NSCs and introduce the Bmi1 oncogene, thus offering a rational to our observations on the retina.
International Nuclear Information System (INIS)
Wu Shiliang; Liu Chunliang; Xu Lan; Zhao Junyu; Qiu Xiuqin
2009-01-01
Objective: To study on the role of PQQ (pyrroloquinoline quinone) in the γ-ray radiation protection of mice. Methods: 40 Kunming mice were randomly divided into four groups, namely, non-irradiated group, the simple exposure group, exposure to pre-treatment group, treatment group after irradiation. PQQ mice oral administration was given according to the weight of the daily dose of 2 mg/kg, continuous drug delivery for 7 days. 60 Co γ-ray single irradiation, dose 5 Gy. On the 8th day after irradiation, the mice were killed by cervical dislocation. The collection of serum, liver homogenate was for the determination of biochemical indicators. HE staining of liver slices produced. Results: irradiated mouse serum and liver SOD, T-AOC decreased significantly (P<0.05), MDA was significantly higher (P<0.05). Radiation treatment group serum SOD, T-AOC were significantly higher (P<0.05), MDA was significantly reduced (P<0.05); liver SOD content was significantly higher (P<0.05). All irradiated mice liver plate shows liver disorders, edema of liver cells, degeneration and necrosis. Conclusion: γ-irradiation in mice induced systemic oxidative stress. Liver is one of the radiation-sensitive organs. PQQ for γ-ray irradiation-induced oxidative stress in mice has some protective effect. Its mechanism: PQQ can directly scavenge free radicals, at the same time, mobilize the whole body irradiated mice scavenging system, particularly the activity of SOD and reduce the generation of free radicals and the free radical content. (authors)
National Data Center Preparedness Exercise 2015 (NPE 2015): MY-NDC Preliminary Analysis Result
International Nuclear Information System (INIS)
Faisal Izwan Abdul Rashid; Muhammed Zulfakar Zolkaffly
2016-01-01
Malaysia has established the CTBT National Data Centre (MY-NDC) in December 2005. MY-NDC is tasked to perform Comprehensive Nuclear-Test-Ban-Treaty (CTBT) data management as well as provide information for Treaty related events to Nuclear Malaysia as CTBT National Authority. In 2015, MY-NDC has participated in the National Data Centre Preparedness Exercise 2015 (NPE 2015). This paper aims at presenting MY-NDC preliminary analysis result of NPE 2015. In NPE 2015, MY-NDC has performed five different analyses, namely, radionuclide, atmospheric transport modelling (ATM), data fusion, seismic analysis and site forensics. The preliminary findings show the hypothetical scenario in NPE 2015 most probably is an uncontained event resulted high release of radionuclide to the air. (author)
Preliminary Results Of LOCA Problem For APR1400 Reactor
International Nuclear Information System (INIS)
Le Dai Dien; Hoang Minh Giang; Le Thi Thu; Vo Thi Huong; Le Van Hong
2011-01-01
Several features of NPP with APR1400 nuclear reactor during a loss of coolant accident (LOCA) are investigated in this study. The report describes some main design characteristics of an engineering safety systems of APR1400 and the thermal hydraulic calculation results for steady-state using MARS and RELAP/SCDAPSIM codes. Large Break LOCA accident has been analyzed and evaluated based on acceptable criteria for ECCS given by US NRC. The results from cold leg break LOCA with broken area of 0.0465 m 2 in case of high pressure safety injection system (HPSI) failed to operate or 2 and 4 HPSI pumps are activated. The preliminary results of this work is a part of collaboration between INST researchers and KAERI experts in using RELAP tool for safety analysis of NPPs. (author)
The Majorana Demonstrator Status and Preliminary Results
Yu, C.-H.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Green, M.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; Othman, G.; Pettus, W.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Ruof, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yumatov, V.; Zhitnikov, I.; Zhu, B. Z.
2018-05-01
The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors and an unprecedented detector energy resolution of 2.5 keV FWHM at Qββ. The MAJORANA collaboration began taking physics data in 2016. This paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.
Barkhausen Effect and Acoustic Emission in a Metallic Glass - Preliminary Results
International Nuclear Information System (INIS)
Lopez Sanchez, R.; Lopez Pumarega, M.I.; Armeite, M.; Piotrkowski, R.; Ruzzante, J.E.
2004-01-01
Magneto Acoustic Emission, which is Barkhausen Noise (BN) and Acoustic Emission (AE), depends on microstructure and existing residual stresses in magnetic materials. Preliminary results obtained by magnetization along two perpendicular directions on a metal glass foil are presented. Signals were analyzed with Statistic, Fast Fourier and Wavelet methods. Results are part of a Joint Research Project of the Faculty of Science, Cantabria University, Spain, and the Elastic Waves Group of the National Atomic Energy Commission, Argentina
Response to Absorber-Focus Coil Preliminary Safety Review Panel
International Nuclear Information System (INIS)
Barr, Giles; Baynham, Elwyn; Black, Edgar; Bradshaw, Tom; Cummings, Mary Anne; Green, Michael A.; Ishimoto, Shigeru; Ivanyushenkov, Yury; Lau, Wing; Zisman, Michael S.
2004-01-01
In this document we provide responses to the various issues raised in the report of the Preliminary Safety Review Panel (see http://mice.iit.edu/mnp/MICE0069.pdf). In some cases we have made design changes in response to the Panels suggestions. In other cases, we have chosen not to do so. In a few cases, we indicate our plans, although the tasks have not yet been completed. For simplicity, the responses are organized along the same lines as those of the Panel Report
Modelled and Observed Diurnal SST Signals: "SSTDV:R.EX.-IM.A.M." Project Preliminary Results
DEFF Research Database (Denmark)
Karagali, Ioanna; Høyer, Jacob; LeBorgne, Pierre
2013-01-01
This study presents some of the preliminary results from the ESA Support To Science Element (STSE) funded project on the Diurnal Variability of the Sea Surface Temperature, regarding its Regional Extend and Implications in Atmospheric Modelling (SSTDV:R.EX.–IM.A.M.). During this phase of the proj......This study presents some of the preliminary results from the ESA Support To Science Element (STSE) funded project on the Diurnal Variability of the Sea Surface Temperature, regarding its Regional Extend and Implications in Atmospheric Modelling (SSTDV:R.EX.–IM.A.M.). During this phase...
Preliminary results of the Spacelab 2 superfluid helium experiment
International Nuclear Information System (INIS)
Mason, P.V.; Collins, D.J.; Elleman, D.D.; Jackson, H.W.; Wang, T.
1986-01-01
An experiment to investigate the properties of superfluid helium in a microgravity environment flew on the Shuttle on the Spacelab 2 mission in July and August of 1985. This paper summarizes the flight experiment and describes some preliminary results. The experiment comprised an investigation of long-wavelength third-sound waves in micron-thick films, a study of the motions of superfluid helium under milli-g and micro-g accelerations, and measurements of the fluctuations in temperature associated with the small motions of the bulk helium. An additional objective was to qualify and characterize a reflyable, space-compatible cryostat
Preliminary results of natural radioactivity measurements in the southern part of Ethiopia
International Nuclear Information System (INIS)
Wollel Tiruneh, Getachew; Wodaje Kebede, Worku
2008-01-01
The paper presents the first results of natural radioactivity measurements in the Southern part of Ethiopia (Bale Zone-Oromiya Regional State). The preliminary results indicate that radiation levels in the mining areas of Kallido Mountain are elevated compared with those in the town of Negele Borena (background area). Both external gamma radiation and alpha surface contamination levels are significantly elevated above local background levels
Preliminary results of natural radioactivity measurements in the southern part of Ethiopia
Energy Technology Data Exchange (ETDEWEB)
Wollel Tiruneh, Getachew [Ethiopian Radiation Protection Authority, PO Box 20486 code 1000, Addis-Ababa (Ethiopia)], E-mail: gwollel@yahoo.com; Wodaje Kebede, Worku [Ethiopian Radiation Protection Authority, PO Box 20486 code 1000, Addis-Ababa (Ethiopia)
2008-11-15
The paper presents the first results of natural radioactivity measurements in the Southern part of Ethiopia (Bale Zone-Oromiya Regional State). The preliminary results indicate that radiation levels in the mining areas of Kallido Mountain are elevated compared with those in the town of Negele Borena (background area). Both external gamma radiation and alpha surface contamination levels are significantly elevated above local background levels.
Magnetic resonance imaging of the brain in neonates. Preliminary results
International Nuclear Information System (INIS)
Dumoulin, M.; Legrand, M.; Gremillet, C.; Lecouffe, P.; Rousseau, J.; Pruvo, J.P.; Marchandise, X.
1991-01-01
The place of neonatal cerebral MRI and its specific contribution compared with conventional imaging techniques were evaluated in 36 patients. The difficulties specific to the patient population studied met during this preliminary period are described, with their local solutions. A preliminary evaluation of the diagnostic and prognostic value of MRI according to the disease state and gestational age is presented. The specific contribution of MRI compared with transfontanellar ultrasonography and CT scan is discussed [fr
Investigation of polarized-proton target materials by differential calorimetry: preliminary results
International Nuclear Information System (INIS)
Hill, D.A.; Hill, J.J.
1980-01-01
A simple differential calorimeter was designed and operated for an investigation of the thermodynamic properties of polarized target materials. The calibration and use of the calorimeter are discussed, after a brief exposition of our motivation for this work. The results of a preliminary study of target materials is presented with emphasis on the relevance of the glass state to dynamic polarization in chemically-doped targets
Response of lead-acid batteries to chopper-controlled discharge: Preliminary results
Cataldo, R. L.
1978-01-01
The preliminary results of simulated electric vehicle, chopper, speed controller discharge of a battery show energy output losses up to 25 percent compared to constant current discharges at the same average discharge current of 100 amperes. These energy losses are manifested as temperature rises during discharge, amounting to a two-fold increase for a 400-ampere pulse compared to the constant current case. Because of the potentially large energy inefficiency, the results suggest that electric vehicle battery/speed controller interaction must be carefully considered in vehicle design.
Preliminary results of spatially resolved ECR ion beam profile investigations
International Nuclear Information System (INIS)
Panitzsch, L.; Stalder, M.; Wimmer-Schweingruber, R.F.
2012-01-01
The profile of an ion beam produced in an Electron Cyclotron Resonance Ion Source (ECRIS) can vary greatly depending on the source settings and the ion-optical tuning. Strongly focussed ion beams form circular structures (hollow beams) as predicted by simulations and observed in experiments. Each of the rings is predicted to be dominated by ions with same or at least similar m/q-ratios due to ion-optical effects. To check this we performed a series of preliminary investigations to test the required tuning capabilities of our ion source. This includes beam focussing (A) and beam steering (B) using a 3D-movable extraction. Having tuned the source to deliver a beam of strongly focussed ions of different ion species and having steered this beam to match the transmittance area of the sector magnet we also recorded the ion charge state distribution of the strongly focussed beam profile at different, spatially limited positions (C). The preliminary results will be introduced within this paper: it appears that our 3D-movable extraction is very efficient to steer and to focus the beam strongly. The paper is followed by the slides of the presentation. (authors)
Preliminary Results of the CASCADE Hidden Sector Photon Search
Woollett, Nathan; Burt, Graeme; Chattopadhyay, Swapan; Dainton, John; Dexter, Amos; Goudket, Phillipe; Jenkins, Michael; Kalliokoski, Matti; Moss, Andrew; Pattalwar, Shrikant; Thakker, Trina; Williams, Peter
2015-01-01
Light shining through a wall experiments can be used to make measurements of photon-WISP couplings. The first stage of the CASCADE experiment at the Cockcroft Institute of Accelerator Science and Technology is intended to be a proof-of-principle experiment utilising standard microwave technologies to make a modular, cryogenic HSP detector to take advantage of future high-power superconducting cavity tests. In these proceedings we will be presenting the preliminary results of the CASCADE LSW experiment showing a peak expected exclusion of $1.10 \\times 10^{-8}$ in the mass range from 1.96$\\mu$eV to 5.38$\\mu$eV, exceeding current limits.
V and V Efforts of Auroral Precipitation Models: Preliminary Results
Zheng, Yihua; Kuznetsova, Masha; Rastaetter, Lutz; Hesse, Michael
2011-01-01
Auroral precipitation models have been valuable both in terms of space weather applications and space science research. Yet very limited testing has been performed regarding model performance. A variety of auroral models are available, including empirical models that are parameterized by geomagnetic indices or upstream solar wind conditions, now casting models that are based on satellite observations, or those derived from physics-based, coupled global models. In this presentation, we will show our preliminary results regarding V&V efforts of some of the models.
Ambient Assisted Living and ageing: preliminary results of RITA project.
Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara
2012-01-01
The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.
Effect of single and fractionated x-irradiation on maze learning ability of mice
International Nuclear Information System (INIS)
Aoyama, Takashi; Norimura, Toshiyuki; Nakamura, Takeshi; Yoshikawa, Isao
1976-01-01
Fifty-six-day-old male ddk mice at the starting of the investigation were used as subjects through the experiment for 64 weeks. After 15 days' preliminary training, and 16 times of weekly trial training using complete maze, 15 mice received a single 224 rads of x-rays (S group), another 15 mice received two 112 rads spaced two weeks apart (F group) and another 15 mice were sham-irradiated (Control group). Then those mice were tested on the multiple T-maze with nine-choice points and change of performance was observed in terms of errorchoices by giving one test trial a week. We introduced the concept of ''confusional trials'' as an index for surmising to what extent mice failed to exhibit good maze learning habits. In the results, the F group showed significantly worse performance than the two other groups at early stages, opposite to it the S group exhibited the same, but at late stages after irradiation. The worse performance of F group should be considered to be due to the psychological after-effect to fractionated irradiation and that for S group could be assumed to be due to the acceleration of aging by the irradiation. (auth.)
201 MHz Cavity R and D for MUCOOL and MICE
International Nuclear Information System (INIS)
Li, Derun; Virostek, Steve; Zisman, Michael; Norem, Jim; Bross, Alan; Moretti, Alfred; Norris, Barry; Torun, Yagmur; Phillips, Larry; Rimmer, Robert; Stirbet, Mircea; Reep, Michael; Summers, Don
2006-01-01
We describe the design, fabrication, analysis and preliminary testing of the prototype 201 MHz copper cavity for a muon ionization cooling channel. Cavity applications include the Muon Ionization Cooling Experiment (MICE) as well as cooling channels for a neutrino factory or a muon collider. This cavity was developed by the US muon cooling (MUCOOL) collaboration and is being tested in the MUCOOL Test Area (MTA) at Fermilab. To achieve a high accelerating gradient, the cavity beam irises are terminated by a pair of curved, thin beryllium windows. Several fabrication methods developed for the cavity and windows are novel and offer significant cost savings as compared to conventional construction methods. The cavity's thermal and structural performances are simulated with an FEA model. Preliminary high power RF commissioning results will be presented
DECOMPOSITION OF TARS IN MICROWAVE PLASMA – PRELIMINARY RESULTS
Directory of Open Access Journals (Sweden)
Mateusz Wnukowski
2014-07-01
Full Text Available The paper refers to the main problem connected with biomass gasification - a presence of tar in a product gas. This paper presents preliminary results of tar decomposition in a microwave plasma reactor. It gives a basic insight into the construction and work of the plasma reactor. During the experiment, researches were carried out on toluene as a tar surrogate. As a carrier gas for toluene and as a plasma agent, nitrogen was used. Flow rates of the gases and the microwave generator’s power were constant during the whole experiment. Results of the experiment showed that the decomposition process of toluene was effective because the decomposition efficiency attained above 95%. The main products of tar decomposition were light hydrocarbons and soot. The article also gives plans for further research in a matter of tar removal from the product gas.
International Nuclear Information System (INIS)
Liang Minyi; Zhang Jinghong; Zhu Weiyun; Li Yinyan; Liang Yongqing; Zhang Songshuan; Zhu Daming; Li Jinlin; Lu Qingpu
2006-01-01
Objective: To observe the effects of radioactivity of the residential granite building materials on the survival and fertility of mice. Methods: The radioactivities of A, B, C, and D granite building materials were measured and screened by gamma-ray spectrometer, and then these materials were placed into the mice cages. The residential radon was measured with solid state nuclear track detector's and 24-hour continuous measurement. Ninety-six healthy and ablactated mice were randomly selected and put into the four animal cages with different levels of radioactivity, and fed for 120 days. Mice mated and bred naturally. The fertilities and survivals of P, F 1 , and F 2 generation were observed and analyzed. Results: External exposures in the four mice cages were higher than those from the internal exposure. The differences of rates of pregnancy, abortion, and infertility between the P and F 1 generations had no statistical significance among all the groups after being fed for 120 days (P>0.05). There was significant difference among each group in the fertility of F 1 generation (P< 0.001), and the survival rates of the offspring were decreased with increase of radioactivity in granite building materials (P<0.001). Conclusion: Compared with the residential radon, the gamma rays released from the granite building materials had a greater influence on animals. The study suggested that different granite building materials had different influences on the survival and fertility of mice. (authors)
Preliminary results of the alpha particle registration intercomparison ALRIT
International Nuclear Information System (INIS)
Paretzke, H.G.
1976-01-01
In view of the widespread interest in alpha particle registration with solid state nuclear track detectors, an international intercomparison of such measurements has been arranged. Sixteen sets of fourteen detectors each were sent to GSF-Neuherberg, there irradiated carefully with different alpha particle fields, and then returned for evaluation. Fourteen irradiation runs were made for each set simulating seven different irradiation situations commonly encountered in practical applications. The preliminary results of this intercomparison reported in this paper are based on the results of eight sets. They show good agreement with respect to the determination of track densities in the case of vertical incident alpha particles. Also the results obtained for determination of particle energies and angle of incidence in most cases were rather accurate. However, apparently it is still rather difficult to determine accurately and precisely the specific activity of alpha emitters on a thick filter positioned at some distance, i.e. for the case of 2π-incidence and a broad energy spectrum. (orig.) [de
The demand factors for cesareans in Portugal – some preliminary results
Tavares, Aida Isabel; Rocha, Tania
2012-01-01
The aim of this work is to determine the demand factors for cesareans in Portugal. This work is exploratory and preliminary. Data is aggregated in NUTSII , for the period 2002-10. The number of cesareans performed is count data which requires the estimation of this panel data by a negative binomial with fixed effects. The main result is the evidence that there may be induced demand for cesareans in Portugal. Further research is needed.
Preliminary results on the Arecibo Pisces-Perseus Supercluster Survey
Cortes, Rosemary; Lebron, Mayra; Jones, Michael G.; Koopmann, Rebecca A.; Haynes, Martha P.; APPSS Team, Undergraduate ALFALFA Team, and the ALFALFA Team
2018-01-01
The Arecibo Pisces-Perseus Supercluster Survey (APPSS) aims to exploit the Baryonic Tully-Fisher Relation to derive distances and peculiar velocities of galaxies in and near the main ridge of the Pisces-Perseus Supercluster (PPS), one of the most prominent features of the Cosmic Web in the nearby Universe. The sample of galaxies contains ~ 600 sources in the low-mass range (8 Team institutions in which each group contributes to the analysis of a subset of the HI PPS data. In this poster, we will present the contributions of the U.P.R. team to the APPSS project. We will show the procedure used for the Arecibo HI data analysis, including some examples, and will show our preliminary results.
Preliminary results of MR imaging of lymphoma: Distinguishing active tumor from benign residue
International Nuclear Information System (INIS)
Drace, J.; Baker, L.L.; Chang, P.; Castellino, R.A.
1987-01-01
Distinguishing tumor from benign posttreatment tissue based on both morphologic and tissue characteristics is critically important. Patients are studied before, during, and after treatment; at the time of recurrence; and on long-term follow-up. Multisection spin-echo sequences in orthogonal planes and a special single-section tissue characterization matrix of 16 different repetition time/echo time combinations are used. These basic images are used for cluster analysis (approximate fuzzy C means), T1-T2 synthetic images, linear combinations, and comparison with internal standards. Preliminary results in 35 patients imaged before treatment and 12 patients with follow-up examinations consistently show lymphoma masses to have complex architecture with high T2-weighted signal and moderate T1-weighted signal, distinct from posttreatment fibrosis. Uncommon components of active tumor with low T2-weighted signal appear distinct from fibrosis on T1-weighted images. Preliminary cluster analysis results show distinct clustering of active lymphoma versus fibrosis and biopsy-proved cystic degeneration
Dissolved air flotation for treating wastewater of the nuclear industry. Preliminary results
International Nuclear Information System (INIS)
Ortiz-Oliveros, H.B.; Jimenez-Moleon, M.C.; Cruz-Gonzalez, D.
2012-01-01
Preliminary testing of dissolved air flotation (DAF) for wastewater treatment is presented. A combined coagulation-flocculation/DAF column system is used to remove oil and 60 Co from nuclear industry wastewater. In this work, operational conditions and coagulant/flocculant concentrations are optimized by varying pH. Determinations of air-solids ratio (G/S), retention time (θ), pressure (P), volume of depressurized air-water mixture (V), turbidity and 60 Co concentrations are reported. The effect of the treatment on the efficiency of separation of oily residues is also discussed. The results establish that the coagulant/flocculant system, formed by a modified polyamine (25 mgL -1 ) and a slightly cationic polyacrylamide (1.5 mgL -1 ), under specific operational conditions (pH = 7, mixing intensity Im 1 = 300 s -1 and Im 2 = 30 s -1 ), allowed the destabilization of colloidal matter, resulting in resistant flocs. It was concluded that by using G/S = 0.3, θ = 15 min, P = 620 kPa and V = 0.0012 m 3 , the greatest percentage removals of oil, turbidity, total cobalt and 60 Co were obtained. These preliminary results then show that dissolved air flotation represents a good alternative for treatment of nuclear industry wastewater contaminated with radionuclides. (author)
Late effects of chronic low dose-rate γ-rays irradiation on mice
International Nuclear Information System (INIS)
Tanaka, Satoshi; Sasagawa, Sumiko; Ichinohe, Kazuaki; Matsumoto, Tsuneya; Otsu, Hiroshi; Sato, Fumiaki
2002-01-01
To evaluate late biological effects of chronic low dose-rate radiation, we are conducting two experiments. Experiment 1 - Late effects of chronic low dose-rate g-rays irradiation on SPF mice, using life-span and pathological changes as parameters. Continuous irradiation with g-rays for 400 days was performed using 137 Cs γ-rays at dose-rates of 20 mGy/day, 1 mGy/day and 0.05 mGy/day with accumulated doses equivalent to 8,000 mGy, 400 mGy and 20 mGy, respectively. All mice were kept until they died a natural death. As of 2002 March 31, 3,999 of the total 4,000 mice have died. Preliminary analyses of data show that 20 mGy/day suggested a shortened life span in both sexes. Partial results show that the most common lethal neoplasms in the pooled data of non-irradiated control and irradiated male mice, in order of frequency, were neoplasms of the lymphohematopoietic system, liver, and lung. In female mice, neoplasms of the lymphohematopoietic system, soft tissue, and endocrine system were common. Experiment 2 - Effects on the progeny of chronic low dose-rate g-ray irradiated SPF mice: pilot study, was started in 1999 and is currently in progress. (author)
The RPC-based IFR system at BaBar experiment: preliminary results
International Nuclear Information System (INIS)
Piccolo, Davide; Palano, A.; Bagnasco, S.; Buzzo, A.; Contri, R.; Crosetti, G.; Lo Vetere, M.; Macri, M.; Monge, R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Anulli, F.; Baldini, R.; Calcaterra, A.; De Sangro, R.; Falciai, D.; Finocchiaro, G.; Patteri, P.; Peruzzi, I.; Piccolo, M.; Yu, Z.; Zallo, A.; Cavallo, N.; De Nardo, G.; Fabozzi, F.; Gatto, C.; Lista, L.; Paolucci, P.; Sciacca, C.; Bionta, R.; Wright, D.; Band, H.; Johnson, J.
2002-01-01
The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported
The RPC-based IFR system at BaBar experiment preliminary results
Piccolo, D; Bagnasco, S; Baldini, R; Band, H R; Bionta, R; Buzzo, A; Calcaterra, A; Cavallo, N; Contri, R; Crosetti, G; De Nardo, Gallieno; De Sangro, R; Fabozzi, F; Falciai, D; Finocchiaro, G; Gatto, C; Johnson, J; Lista, L; Lo Vetere, M; Macri, M; Monge, R; Palano, A; Paolucci, P; Passaggio, S; Patrignani, C; Patteri, P; Peruzzi, I; Piccolo, M; Robutti, E; Santroni, A; Sciacca, C; Wright, D; Yu, Z; Zallo, A
2002-01-01
The IFR system is a RPC-based detector used to identify muons and neutral hadrons in the BaBar experiment at PEP II machine in SLAC. The RPC system can be used to reconstruct the trajectory of muons, pions and neutral hadrons interacting in the iron of the IFR. The different range and hit pattern allow to discriminate different particles crossing the IFR. An overview of the system design and the preliminary results on the IFR performances are reported.
KEEP Reading Research 1974: Overall Strategy and Preliminary Results. Technical Report No. 23.
Tharp, Roland G.; And Others
Reading research is an important aspect of the Kamehameha Early Education Program. This report describes the overall strategy of the reading research program, which is based on a conceptual framework that divides lines of inquiry into motivation, linguistics, instructional procedures, and correlational analysis. Preliminary results for each of…
A preliminary study on the pathogenicity of Bacillus licheniformis bacteria in immunodepressed mice
DEFF Research Database (Denmark)
Agerholm, J.S.; Jensen, N.E.; Giese, Steen Bjørck
1997-01-01
The pathogenicity of 13 strains of Bacillus licheniformis was studied in immunodepressed mice. The strains had been isolated from cases of bovine abortions (n=5), bovine feedstuffs (n=3), soil (n=l), and grain products (n=2). The origin of two strains was unknown. Groups of 10 mice were inoculated...... intravenously with B. licheniformis bacteria at doses from...
Preliminary investigation into aerosol mobilization resulting from fusion reactor disruptions
International Nuclear Information System (INIS)
Sharpe, J.P.; Bourham, M.A.; Gilligan, J.G.
1996-01-01
An experimental system has been developed to study disruption-induced aerosol mobilization for fusion accident analysis. The SIRENS high heat flux facility at North Carolina State University has been modified to closely simulate disruption conditions expected in tokamak reactors. A hot vapor is formed by an ablation-controlled arc and expansion cooled into a glass chamber, where particle condensation and growth occur. The particles are collected and analyzed for relevant transport properties (e.g. size distribution and shape). Particle characterization methods are discussed, and preliminary results based on simple analysis techniques are given. 2 refs., 6 figs
Escherichia coli O26 IN RAW BUFFALO MILK: PRELIMINARY RESULTS
Directory of Open Access Journals (Sweden)
A. Rella
2013-02-01
Full Text Available Escherichia coli O26 is considered to be one of the most important food-borne pathogen. In this study, 120 buffalo milk samples collected in Lazio and in Apulia regions were tested for the presence of E. coli O26. One buffalo milk sample (0,8% tested positive for E. coli O26; the isolate was positive at the verocytotoxicity test and it showed resistance properties to different antimicrobial classes. These preliminary results highlight the need to monitor the foods of animal origin used for production and eaten by a wide range of persons, respect VTEC organism.
SmallWorld Behavior of the Worldwide Active Volcanoes Network: Preliminary Results
Spata, A.; Bonforte, A.; Nunnari, G.; Puglisi, G.
2009-12-01
We propose a preliminary complex networks based approach in order to model and characterize volcanoes activity correlation observed on a planetary scale over the last two thousand years. Worldwide volcanic activity is in fact related to the general plate tectonics that locally drives the faults activity, that in turn controls the magma upraise beneath the volcanoes. To find correlations among different volcanoes could indicate a common underlying mechanism driving their activity and could help us interpreting the deeper common dynamics controlling their unrest. All the first evidences found testing the procedure, suggest the suitability of this analysis to investigate global volcanism related to plate tectonics. The first correlations found, in fact, indicate that an underlying common large-scale dynamics seems to drive volcanic activity at least around the Pacific plate, where it collides and subduces beneath American, Eurasian and Australian plates. From this still preliminary analysis, also more complex relationships among volcanoes lying on different tectonic margins have been found, suggesting some more complex interrelationships between different plates. The understanding of eventually detected correlations could be also used to further implement warning systems, relating the unrest probabilities of a specific volcano also to the ongoing activity to the correlated ones. Our preliminary results suggest that, as for other many physical and biological systems, an underlying organizing principle of planetary volcanoes activity might exist and it could be a small-world principle. In fact we found that, from a topological perspective, volcanoes correlations are characterized by the typical features of small-world network: a high clustering coefficient and a low characteristic path length. These features confirm that global volcanoes activity is characterized by both short and long-range correlations. We stress here the fact that numerical simulation carried out in
Preliminary results from the MINERvA experiment
International Nuclear Information System (INIS)
Harris, Deborah A.
2011-01-01
The MINERvA experiment, operating since 2009 in the NuMI neutrino beam line at Fermilab, has collected neutrino and antineutrino scattering data on a variety of nuclear targets. The detector is designed to identify events originating in plastic scintillator, lead, carbon, iron, water, and liquid helium. The goal of the experiment is to measure inclusive and exclusive cross sections for neutrino and antineutrino with much greater precision than previous experiments. We present preliminary kinematic distributions for charged current quasi-elastic scattering and other processes.
Antihyperglycemic and subchronic toxicity study of Moringa stenopetala leaves in mice
Directory of Open Access Journals (Sweden)
Tesemma Sileshi
2014-03-01
Full Text Available Objective: To evaluate the antihyperglycemic activity and subchronic toxicity of an extract of Moringa stenopetala (M. stenopetala leaves in mice. Methods: Antihyperglycemic activities of various solvent subfractions and chromatographic fractions were investigated in alloxan induced diabetic mice. All fractions were administered intragastrically using oral gavage at a dose of 500 mg/kg. For the subchronic toxicity investigation of the 70% ethanol extract of M. stenopetala leaves, a daily dose of 300 or 600 mg/kg body weight was administered to mice over 96 d. Some hematological and plasma biochemical parameters were measured as indices of organ specific toxicity. Preliminary phytochemical screening and antioxidant activity investigation was done using thin layer chromatography method. Results: Among the solvent subfractions of the 70% ethanol extract tested only butanol subfraction exhibited significant reduction of blood glucose level (P<0.05 at 2 h (53.44% and 4.5 h (46.34% in diabetic mice and it was further fractionated chromatographically. This resulted in isolation of three chromatographic fractions (fraction 1, 2, and 3 which exhibited maximal blood glucose reduction (P<0.01 at 6 h (77.2%, at 4.5 h (69.1% and at 4.5 h (71.96% after administration. Furthermore, these fractions exhibited comparable antioxidant activity, and preliminary phytochemical screening indicated the presence of phenolic compounds which may be phenolic glycoside in all fractions. The subchronic toxicity study of the 70% ethanol extract of M. stenopetala leaves revealed that there were no significant differences in body weight, between controls and treated mice. Hematological analysis showed no differences in most parameters examined. Furthermore, it did not significantly affect plasma creatinine, urea, cholesterol, triglycerides and CA125 levels. It also did not significantly affect the plasma T3, T4 and THS level. It, however, caused a significant dose
Vivo dosimetry using TLD detectors in prostate seed implants of I-125: preliminary results
International Nuclear Information System (INIS)
Sanchez-Reyes, A.; Pedro, A.; Bassas, P.; Duch, M. A.; Cros, M.; Mane, S.
2011-01-01
We present preliminary results of a new in vivo dosimetry technique that could allow to know immediately after implantation of the prostate if the dose distribution determined by the scheduler is similar to the actual dose measured with TLD detectors.
2012-11-06
... DEPARTMENT OF COMMERCE International Trade Administration [A-533-813] Certain Preserved Mushrooms... preserved mushrooms (mushrooms) from India. The period of review (POR) is February 1, 2011, through January... Preliminary Results of Antidumping Duty Administrative Review: Certain Preserved Mushrooms from India...
Chemical Analysis of the Moon at the Surveyor VII Landing Site: Preliminary Results.
Turkevich, A L; Franzgrote, E J; Patterson, J H
1968-10-04
The alpha-scattering experiment aboard Surveyor VII has provided a chemical analysis of the moon in the area of the crater Tycho. The preliminary results indicate a chemical composition similar to that already found at two mare sites, but with a lower concentration of elements of the iron group (titanium through copper).
Aerosol composition in a stagnant air mass impacted by dense fogs: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Jacob, D.J.; Munger, J.W.; Waldman, J.M.; Hoffman, M.R.
1984-01-01
Over the last two winters, our research group has been investigating the chemical composition of fogwater and haze aerosol during wintertime stagnation episodes in the San Joaquin Valley of California. The valley is encompassed by mountain ranges. During the winter a strong subsidence inversion based below the natural boundaries of the valley restricts the ventilation of the air masses below the inversion. The residence time of an air parcel in the valley under these stagnation conditions is on the order of 8 days. Because the trapped air is very humid, stagnation episodes are associated with a persistent thick haze and frequent widespread nighttime fogs. During the winter 1982-1983 the authors sampled fog and haze at one site (Bakersfield); results from this preliminary study have been discussed in detail in a previous report. In the winter 1983-1984 the scale of the program was expanded in order to test hypotheses formulated as a result of first year data. The present paper first reports briefly on the 1982-1983 results and outlines the essential conclusions. They then describe the large-scale experiment conducted during the winter of 1983-1984, and discuss some preliminary fogwater data.
International Nuclear Information System (INIS)
Asher, R.C.; Bullen, D.; Davies, D.
1976-03-01
Preliminary experiments are reported on the relationship between the injection mode of contact and the occurrence and magnitude of vapour explosions. Water was injected beneath the surface of molten metals, chiefly tin at 250 to 900 0 C. Vapour explosions occurred in many, but not all, cases. The results are compared with Dullforce's observations (Culham Report (CLM-P424) on the dropping mode of contact and it appears that rather different behaviour is found; in particular, the present results suggest that the Temperature Interaction Zone is different for the two modes of contact. (author)
Kathy James; Leo H. McAvoy
1992-01-01
This study presents preliminary result interviews with people of color working in environmental education and interpretation throughout the United States. The three primary questions asked were these? (1) What path led each individual to a career in environmental education; (2) How does each individual define environmentalism? and (3) What are the primary issues this...
Radiation Testing on State-of-the-Art CMOS: Challenges, Plans, and Preliminary Results
LaBel, Kenneth A.; Cohn, Lewis M.
2009-01-01
At GOMAC 2007 and 2008, we discussed a variety of challenges for radiation testing of modern semiconductor devices and technologies [1, 2]. In this presentation, we provide more specific details in this on-going investigation focusing on out-of-the-box lessons observed for providing radiation effects assurances as well as preliminary test results.
International Nuclear Information System (INIS)
Ren Minqin; Huang En; Beck, Konstanze; Rajendran, Reshmi; Wu, Ben J.; Halliwell, Barry; Watt, Frank; Stocker, Roland
2007-01-01
Atherosclerosis is a progressive disease that causes lesions in large and medium-sized arteries. There is increasing evidence that the function of vascular endothelial cells is impaired by oxidation reactions, and that metal ions may participate in these processes. The nuclear microscopy facility in NUS, which has the ability to focus a 2 MeV proton beam down to sub micron spot sizes, was used to investigate the trace elemental changes (e.g. Zn and Fe) in atherosclerotic lesions in the common carotid artery of apolipoprotein E deficient mice fed a high fat diet. In this preliminary study, which is part of a larger study to investigate the effects of probucol on carotid artery atherosclerosis, two sets of mice were used; a test set fed a high fat diet +1% probucol, and a control set which was fed a high fat diet only. The results show that the Zn/Fe ratio was significantly higher in the media of arteries of probucol treated animals without overlying lesion (4.3) compared to the media with overlying lesion (1.3) (p = 0.004) for test mice. For the control mice, the arterial Zn/Fe ratio was 1.8 for media without overlying lesion, compared with 1.0 for media with overlying lesion (p = 0.1). Thus, for media without overlying lesion, the Zn/Fe ratio was significantly higher (p = 0.009) in probucol-treated (4.3) than control mice (1.8), whereas there was little difference in the ratios between the two groups in media with overlying lesion (1.3 compared with 1.0). These preliminary results are consistent with the idea that the levels of iron and zinc concentrations within the artery wall may influence the formation of atherosclerotic plaque in the carotid artery
Chemical Analysis of the Moon at the Surveyor VI Landing Site: Preliminary Results.
Turkevich, A L; Patterson, J H; Franzgrote, E J
1968-06-07
The alpha-scattering experiment aboard soft-landing Surveyor VI has provided a chemical analysis of the surface of the moon in Sinus Medii. The preliminary results indicate that, within experimental errors, the composition is the same as that found by Surveyor V in Mare Tranquillitatis. This finding suggests that large portions of the lunar maria resemble basalt in composition.
Creanga, Dorina; Balasoiu, Maria; Soloviov, Dmitro; Balasoiu-Gaina, Alexandra-Maria; Puscasu, Emil; Lupu, Nicoleta; Stan, Cristina
2018-03-01
Preliminary small-angle neutron scattering investigations on aqueous suspensions of several cobalt doped ferrites (CoxFe3-xO4, x=0; 0.5; 1) nanoparticles prepared by chemical co-precipitation method, are reported. The measurements were accomplished at the YuMO instrument in function at the IBR-2 reactor. Results of intermediary data treatment are presented and discussed.
Preliminary results of a battery-based, multi megawatt 200 kA pulsed power supply.
Karthaus, W.; Kolkert, W.J.; Nowee, J.
1989-01-01
A pulsed power supply consisting of a fast discharge battery, a switch based on silicon-controlled-rectifier SCR technology, and an energy storage/pulse transformer is discussed. Preliminary results indicate that the battery is capable of discharging current pulses with reproducible peak values of
2013-05-14
... Bags From Thailand: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012 AGENCY... on polyethylene retail carrier bags (PRCBs) from Thailand. The review covers 11 respondents. The... merchandise has been sold at less than normal value by the companies subject to this review. DATES: Effective...
Preliminary results on tests of a Cerenkov ring imaging device employing a photoionizing PWC
Energy Technology Data Exchange (ETDEWEB)
Durkin, S.; Honma, A.; Leith, D.W.G.S.
1978-08-01
A brief description of techniques and problems of ring imaging Cerenkov detectors employing photoionizing PWC's is discussed. Preliminary results on a one dimensional ring imaging device tested at SLAC in May and June of 1978 are then presented. These results include rough measurements of the Cerenkov ring in nitrogen, argon, neon, and helium produced by a collimated positron beam.
Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
Suidan, Georgette L; Duerschmied, Daniel; Dillon, Gregory M; Vanderhorst, Veronique; Hampton, Thomas G; Wong, Siu Ling; Voorhees, Jaymie R; Wagner, Denisa D
2013-01-01
The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limiting enzyme involved in the biosynthesis of peripheral serotonin. Serotonin released into circulation is taken up by platelets via the serotonin transporter and stored in dense granules. It has been previously reported that mouse embryos removed from Tph1-deficient mothers present abnormal nervous system morphology. The goal of this study was to assess whether Tph1-deficiency results in behavioral abnormalities. We did not find any differences between Tph1-deficient and wild-type mice in general motor behavior as tested by rotarod, grip-strength test, open field and beam walk. However, here we report that Tph1 (-/-) mice display altered gait dynamics and deficits in rearing behavior compared to wild-type (WT) suggesting that tryptophan hydroxylase-1 expression has an impact on the nervous system.
Hybrid Spectral Micro-CT: System Design, Implementation, and Preliminary Results
Bennett, James R; Xu, Qiong; Yu, Hengyong; Walsh, Michael; Butler, Anthony; Butler, Phillip; Cao, Guohua; Mohs, Aaron; Wang, Ge
2014-01-01
Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu et al. reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral "interior" imaging chain integrated with a traditional wide-beam "global" imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.
Approach to the fracture hydrology at Stripa: preliminary results
International Nuclear Information System (INIS)
Gale, J.E.; Witherspoon, P.A.
1979-05-01
There are two main problems associated with the concept of geologic storage of radioactive waste in fractured crystalline rock: (1) the thermo-mechanical effects of the heat generated by the waste, and (2) the potential for transport of radioactive materials by the groundwater system. In both problems, fractures play a dominant role. An assessment of the hydraulic and mechanical characteristics of fractued rock requires a careful series of laboratory and field investigations. The complexity of the problem is illustrated by the field studies in a fractured granite that are currently underway in an abandoned iron-ore mine at Stripa, Sweden. Much information is being gathered from an extensive series of boreholes and fracture maps. The approach being taken to integrate these data into an analysis of the fracture hydrology is reviewed and preliminary results from the hydrology program are presented. 13 figures
Mice in Bion-M 1 Space Mission: Training and Selection
Andreev-Andrievskiy, Alexander; Popova, Anfisa; Boyle, Richard; Alberts, Jeffrey; Shenkman, Boris; Vinogradova, Olga; Dolgov, Oleg; Anokhin, Konstantin; Tsvirkun, Darya; Soldatov, Pavel; Nemirovskaya, Tatyana; Ilyin, Eugeniy; Sychev, Vladimir
2014-01-01
After a 16-year hiatus, Russia has resumed its program of biomedical research in space, with the successful 30-day flight of the Bion-M 1 biosatellite (April 19–May 19, 2013). The principal species for biomedical research in this project was the mouse. This paper presents an overview of the scientific goals, the experimental design and the mouse training/selection program. The aim of mice experiments in the Bion-M 1 project was to elucidate cellular and molecular mechanisms, underlying the adaptation of key physiological systems to long-term exposure in microgravity. The studies with mice combined in vivo measurements, both in flight and post-flight (including continuous blood pressure measurement), with extensive in vitro studies carried out shortly after return of the mice and in the end of recovery study. Male C57/BL6 mice group housed in space habitats were flown aboard the Bion-M 1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control groups were used to account for housing effects and possible seasonal differences. Mice training included the co-adaptation in housing groups and mice adaptation to paste food diet. The measures taken to co-adapt aggressive male mice in housing groups and the peculiarities of “space” paste food are described. The training program for mice designated for in vivo studies was broader and included behavioral/functional test battery and continuous behavioral measurements in the home-cage. The results of the preliminary tests were used for the selection of homogenous groups. After the flight, mice were in good condition for biomedical studies and displayed signs of pronounced disadaptation to Earth's gravity. The outcomes of the training program for the mice welfare are discussed. We conclude that our training program was effective and that male mice can be successfully employed in space biomedical research. PMID:25133741
Monte Carlo simulation of a TRIGA source driven core configuration: Preliminary results
International Nuclear Information System (INIS)
Burgio, N.; Ciavola, C.; Santagata, A.
2002-01-01
The different core configurations with a k eff ranging from 0.93 to 0.98, and their response when driven by a pulsed neutron source were simulated with MCNP4C3 (Los Alamos - Monte Carlo N Particles). Simulation results could be considered both as preliminary check for nuclear data and a conceptual design for 'source jerk' experiments on the frame of TRIGA Accelerator Driven Experiment (TRADE) on the reactor facility of Casaccia research center. (author)
Preliminary Results Of PCA On MRO CRISM Multispectral Images
Klassen, David R.; Smith, M. D.
2008-09-01
Mars Reconnaissance Orbiter arrived at Mars in March 2006 and by September had achieved its science-phase orbit with the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) beginning its visible to near-infrared (VIS/NIR) spectral imaging shortly thereafter. One of the goals of CRISM is to fill in the spatial gaps between the various targeted observations, eventually mapping the entire surface. Due to the large volume of data this would create, the instrument works in a reduced spectral sampling mode creating "multispectral” images. From this data we can create image cubes using 70 wavelengths from 0.410 to 3.504 µm. We present here a preliminary analysis of these multispectral mode data products using the technique of Principal Components Analysis. Previous work with ground-based images has shown that over an entire visible hemisphere, there are only three to four meaningful components out of 32-105 wavelengths over 1.5-4.1 µm. The first two of these components are fairly consistent over all time intervals from day-to-day and season-to-season. [1-4] The preliminary work on the CRISM images cubes implies similar results_three to four significant principal components that are fairly consistent over time. We will show these components and a rough linear mixture modeling based on in-data spectral endmembers derived from the extrema of the principal components [5]. References: [1] Klassen, D. R. and Bell III, J. F. (2001) BAAS 33, 1069. [2] Klassen, D. R. and Bell III, J. F. (2003) BAAS, 35, 936. [3] Klassen, D. R., Wark, T. J., Cugliotta, C. G. (2005) BAAS, 37, 693. [4] Klassen, D. R. and Bell III, J. F. (2007) in preparation. [5] Klassen, D. R. and Bell III, J. F. (2000) BAAS, 32, 1105.
Preliminary results of a feasibility study for a hard x-ray Kirkpatrick-Baez telescope
DEFF Research Database (Denmark)
Joensen, Karsten D.; Gorenstein, Paul; Wood, James L.
1994-01-01
the preliminary results of a feasibility study of a multifocus Kirkpatrick-Baez telescope. We conclude that high quality multilayers can be performed on relevant thin large flat substrate with adequate uniformity, and that existing deposition chambers can produce the multilayers at a rate of 0.42 m2 per day, so...
Jovian seismology: preliminary results of the SYMPA instrument
Gaulme, P.; Schmider, F. X.; Gay, J.; Jacob, C.; Jeanneaux, F.; Alvarez, M.; Reyes, M.; Valtier, J. C.; Fossat, E.; Palle, P. L.; Belmonte, J. C.; Gelly, B.
2006-06-01
Jupiter's internal structure is poorly known (Guillot et al. 2004). Seismology is a powerful tool to investigate the internal structure of planets and stars, by analyzing how acoustic waves propagate. Mosser (1997) and Gudkova & Zarkhov (1999) showed that the detection and the identification of non-radial modes up to degree ℓ=25 can constrain strongly the internal structure. SYMPA is a ground-based network project dedicated to the Jovian oscillations (Schmider et al. 2002). The instrument is composed of a Mach-Zehnder interferometer producing four interferograms of the planetary spectrum. The combination of the four images in phase quadrature allows the reconstruction of the incident light phase, which is related to the Doppler shift generated by the oscillations. Two SYMPA instruments were built at the Nice university and were used simultaneously during two observation campaigns, in 2004 and 2005, at the San Pedro Martir observatory (Mexico) and the Teide observatory (Las Canarias). We will present for the first time the data processing and the preliminary results of the experiment.
Nuclear Reactor Component Code CUPID-I: Numerical Scheme and Preliminary Assessment Results
International Nuclear Information System (INIS)
Cho, Hyoung Kyu; Jeong, Jae Jun; Park, Ik Kyu; Kim, Jong Tae; Yoon, Han Young
2007-12-01
A component scale thermal hydraulic analysis code, CUPID (Component Unstructured Program for Interfacial Dynamics), is being developed for the analysis of components of a nuclear reactor, such as reactor vessel, steam generator, containment, etc. It adopted three-dimensional, transient, two phase and three-field model. In order to develop the numerical schemes for the three-field model, various numerical schemes have been examined including the SMAC, semi-implicit ICE, SIMPLE, Row Scheme and so on. Among them, the ICE scheme for the three-field model was presented in the present report. The CUPID code is utilizing unstructured mesh for the simulation of complicated geometries of the nuclear reactor components. The conventional ICE scheme that was applied to RELAP5 and COBRA-TF, therefore, were modified for the application to the unstructured mesh. Preliminary calculations for the unstructured semi-implicit ICE scheme have been conducted for a verification of the numerical method from a qualitative point of view. The preliminary calculation results showed that the present numerical scheme is robust and efficient for the prediction of phase changes and flow transitions due to a boiling and a flashing. These calculation results also showed the strong coupling between the pressure and void fraction changes. Thus, it is believed that the semi-implicit ICE scheme can be utilized for transient two-phase flows in a component of a nuclear reactor
Nuclear Reactor Component Code CUPID-I: Numerical Scheme and Preliminary Assessment Results
Energy Technology Data Exchange (ETDEWEB)
Cho, Hyoung Kyu; Jeong, Jae Jun; Park, Ik Kyu; Kim, Jong Tae; Yoon, Han Young
2007-12-15
A component scale thermal hydraulic analysis code, CUPID (Component Unstructured Program for Interfacial Dynamics), is being developed for the analysis of components of a nuclear reactor, such as reactor vessel, steam generator, containment, etc. It adopted three-dimensional, transient, two phase and three-field model. In order to develop the numerical schemes for the three-field model, various numerical schemes have been examined including the SMAC, semi-implicit ICE, SIMPLE, Row Scheme and so on. Among them, the ICE scheme for the three-field model was presented in the present report. The CUPID code is utilizing unstructured mesh for the simulation of complicated geometries of the nuclear reactor components. The conventional ICE scheme that was applied to RELAP5 and COBRA-TF, therefore, were modified for the application to the unstructured mesh. Preliminary calculations for the unstructured semi-implicit ICE scheme have been conducted for a verification of the numerical method from a qualitative point of view. The preliminary calculation results showed that the present numerical scheme is robust and efficient for the prediction of phase changes and flow transitions due to a boiling and a flashing. These calculation results also showed the strong coupling between the pressure and void fraction changes. Thus, it is believed that the semi-implicit ICE scheme can be utilized for transient two-phase flows in a component of a nuclear reactor.
Directory of Open Access Journals (Sweden)
Barril G
2012-06-01
CONCLUSIONS: 1-The preliminary results show that MidDilution provides a good removal of small and middle molecules, increases appetite by providing a proper balance of cytokines through stimulation of antiinflamatory ones and neuropeptide Y. 2-It provides an improvement of body composition. Finally MidDilution improves nutritional parameters which leads to a better quality of life, as well as physical and mental status.
Preliminary results from the Orbiting Solar Observatory 8 - Observations of optically thin lines
Shine, R. A.; Roussel-Dupre, D.; Bruner, E. C., Jr.; Chipman, E. G.; Lites, B. W.; Rottman, G. J.; Athay, R. G.; White, O. R.
1976-01-01
The University of Colorado spectrometer aboard OSO 8 has measured the high temperature C IV resonance lines (at 1548 and 1551 A) and the Si IV resonance lines (at 1393 and 1402 A) formed in the solar chromosphere-corona transition region. Preliminary results include studies of mean profiles, a comparison of cell and network profiles, and the behavior of the lines at the extreme solar limb.
Preliminary results from a study of the double beta decay of 150Nd
International Nuclear Information System (INIS)
Perillo, I.M.C.; Chan, Y.D.; Hurley, D.; Lesko, K.T.; McDonald, R.J.; Moorhead, M.E.; Norman, E.B.; Smith, A.R.; Stokstad, R.G.
1996-01-01
We report the preliminary results from a study of the double beta decay of 150 Nd to the first 0 + excited state of 150 Sm. Our data consists of 50 days of counting 5 kg of natural Nd 2 O 3 at the LBNL-Oroville low background facility. The deduced lower limit for the half life of this decay mode is 4.9.10 19 years. (orig.)
Energy Technology Data Exchange (ETDEWEB)
Rusu, Mirabela, E-mail: mirabela.rusu@gmail.com; Wang, Haibo; Madabhushi, Anant [Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 (United States); Golden, Thea; Gow, Andrew [Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854 (United States)
2015-08-15
inflammation in a mouse model. The authors’ evaluation considered three mice, two with an inflammation phenotype and one control. The authors’ iterative 3D histology reconstruction yielded a 70.1% ± 2.7% overlap with the ex vivo MRI volume. Across a total of 17 anatomic landmarks manually delineated at the division of airways, the target registration error between the ex vivo MRI and 3D histology reconstruction was 0.85 ± 0.44 mm, suggesting that a good alignment of the ex vivo 3D histology and ex vivo MRI had been achieved. The 3D histology-in vivo MRI coregistered volumes resulted in an overlap of 73.7% ± 0.9%. Preliminary computerized feature analysis was performed on an additional four control mice, for a total of seven mice considered in this study. Gabor texture filters appeared to best capture differences between the inflamed and noninflamed regions on MRI. Conclusions: The authors’ 3D histology reconstruction and multimodal registration framework were successfully employed to reconstruct the histology volume of the lung and fuse it with in vivo MRI to create a ground truth map for inflammation on in vivo MRI. The analytic platform presented here lays the framework for a rigorous validation of the identified imaging features for chronic lung inflammation on MRI in a large prospective cohort.
International Nuclear Information System (INIS)
Rusu, Mirabela; Wang, Haibo; Madabhushi, Anant; Golden, Thea; Gow, Andrew
2015-01-01
inflammation in a mouse model. The authors’ evaluation considered three mice, two with an inflammation phenotype and one control. The authors’ iterative 3D histology reconstruction yielded a 70.1% ± 2.7% overlap with the ex vivo MRI volume. Across a total of 17 anatomic landmarks manually delineated at the division of airways, the target registration error between the ex vivo MRI and 3D histology reconstruction was 0.85 ± 0.44 mm, suggesting that a good alignment of the ex vivo 3D histology and ex vivo MRI had been achieved. The 3D histology-in vivo MRI coregistered volumes resulted in an overlap of 73.7% ± 0.9%. Preliminary computerized feature analysis was performed on an additional four control mice, for a total of seven mice considered in this study. Gabor texture filters appeared to best capture differences between the inflamed and noninflamed regions on MRI. Conclusions: The authors’ 3D histology reconstruction and multimodal registration framework were successfully employed to reconstruct the histology volume of the lung and fuse it with in vivo MRI to create a ground truth map for inflammation on in vivo MRI. The analytic platform presented here lays the framework for a rigorous validation of the identified imaging features for chronic lung inflammation on MRI in a large prospective cohort
2011-05-06
... to represent the total net realizable value (NRV) of raw magnesium, it used this value as the offset... AVISMA did not make sales to the United States at less than normal value. If these preliminary results... Than Fair Value: Pure Magnesium in Granular Form From the People's Republic of China, 66 FR 49345...
Directory of Open Access Journals (Sweden)
Yubin Wang
2016-06-01
Full Text Available A CAPN1 missense mutation in Parson Russell Terrier dogs is associated with spinocerebellar ataxia. We now report that homozygous or heterozygous CAPN1-null mutations in humans result in cerebellar ataxia and limb spasticity in four independent pedigrees. Calpain-1 knockout (KO mice also exhibit a mild form of ataxia due to abnormal cerebellar development, including enhanced neuronal apoptosis, decreased number of cerebellar granule cells, and altered synaptic transmission. Enhanced apoptosis is due to absence of calpain-1-mediated cleavage of PH domain and leucine-rich repeat protein phosphatase 1 (PHLPP1, which results in inhibition of the Akt pro-survival pathway in developing granule cells. Injection of neonatal mice with the indirect Akt activator, bisperoxovanadium, or crossing calpain-1 KO mice with PHLPP1 KO mice prevented increased postnatal cerebellar granule cell apoptosis and restored granule cell density and motor coordination in adult mice. Thus, mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
International Nuclear Information System (INIS)
Lu, A.H.; Phillips, S.J.; Adams, M.R.
1982-09-01
Barriers to reduce infiltration into waste burial disposal structures (trenches, pits, etc.) may be required to provide adequate waste confinement. The preliminary engineering design of these barriers should consider interrelated barrier performance factors. This paper summarizes preliminary computer simulation activities to further engineering barrier design efforts. Several barrier configurations were conceived and evaluated. Models were simulated for each barrier configuration using a finite element computer code. Results of this preliminary evaluation indicate that barrier configurations, depending on their morphology and materials, may significantly influence infiltration, flux, drainage, and storage of water through and within waste disposal structures. 9 figures
The evaluation of GL impact in Physical sciences using bibliometric indicators : preliminary results
Di Cesare, Rosa (CNR); GreyNet, Grey Literature Network Service
1994-01-01
A bibliometric study of the Italian grey literature in SIGLE database. Preliminary results. Given the increasing importance of Grey Literature (GL) for the information and documentation field, it is essential to apply a bibliometric analysis similar to the one widely used for the conventional literature. Study objectives: 1) impact evalutation of grey literature in physical sciences; and 2) differentiation between scientific and non scientific grey literature documents in the same discipline,...
2013-02-01
... DEPARTMENT OF COMMERCE International Trade Administration [A-533-810] Stainless Steel Bar From... steel bar (SSB) from India. The period of review (POR) is February 1, 2011, through January 31, 2012... Preliminary Results of Antidumping Duty Administrative Review: Stainless Steel Bar from India'' dated...
Tissue characterization using magnetic resonance elastography: preliminary results
International Nuclear Information System (INIS)
Kruse, S.A.; Smith, J.A.; Lawrence, A.J.; Dresner, M.A.; Manduca, A.; Greenleaf, J.F.; Ehman, R.L.
2000-01-01
The well-documented effectiveness of palpation as a diagnostic technique for detecting cancer and other diseases has provided motivation for developing imaging techniques for non-invasively evaluating the mechanical properties of tissue. A recently described approach for elasticity imaging, using propagating acoustic shear waves and phase-contrast MRI, has been called magnetic resonance elastography (MRE). The purpose of this work was to conduct preliminary studies to define methods for using MRE as a tool for addressing the paucity of quantitative tissue mechanical property data in the literature. Fresh animal liver and kidney tissue specimens were evaluated with MRE at multiple shear wave frequencies. The influence of specimen temperature and orientation on measurements of stiffness was studied in skeletal muscle. The results demonstrated that all of the materials tested (liver, kidney, muscle and tissue-simulating gel) exhibit systematic dependence of shear stiffness on shear rate. These data are consistent with a viscoelastic model of tissue mechanical properties, allowing calculation of two independent tissue properties from multiple-frequency MRE data: shear modulus and shear viscosity. The shear stiffness of tissue can be substantially affected by specimen temperature. The results also demonstrated evidence of shear anisotropy in skeletal muscle but not liver tissue. The measured shear stiffness in skeletal muscle was found to depend on both the direction of propagation and polarization of the shear waves. (author)
Preliminary experimental results from a linear reciprocating magnetic refrigerator prototype
International Nuclear Information System (INIS)
Tagliafico, Luca Antonio; Scarpa, Federico; Valsuani, Federico; Tagliafico, Giulio
2013-01-01
A linear reciprocating magnetic refrigerator prototype was designed and built with the aid of an industrial partner. The refrigerator is based on the Active Magnetic Regenerative cycle, and exploits two regenerators working in parallel. The active material is Gadolinium in plates, 0.8 mm thick, for a total mass of 0.36 kg. The device is described and results about magnetic field and temperature span measurements are presented. The designed permanent magnet structure, based on an improved cross-type arrangement, generates a maximum magnetic field intensity of 1.55 T in air, over a gap of (13 × 50 × 100) mm 3 . The maximum temperature span achieved is 5.0 K, in a free run condition. -- Highlights: ► We give preliminary results from a linear reciprocating magnetic refrigerator prototype. ► The design is intended to process visualization and investigation. ► The prototype behavior gives us various suggestions to improve its general performance
Directory of Open Access Journals (Sweden)
B Cisterna
2009-08-01
Full Text Available In eukaryotic cells, pre-mRNAs undergo several transformation steps to generate mature mRNAs. Recent studies have demonstrated that a diet containing a genetically modified (GM soybean can induce modifications of nuclear constituents involved in RNA processing in some tissues of young, adult and old mice. On this basis, we have investigated the ultrastructural and immunocytochemical features of pre-implantation embryos from mice fed either GM or non- GM soybean in order to verify whether the parental diet can affect the morpho-functional development of the embryonic ribonucleoprotein structural constituents involved in premRNA pathways. Morphological observations revealed that the general aspect of embryo nuclear components is similar in the two experimental groups. However, immunocytochemical and in situ hybridization results suggest a temporary decrease of pre-mRNA transcription and splicing in 2-cell embryos and a resumption in 4-8-cell embryos from mice fed GM soybean; moreover, pre-mRNA maturation seems to be less efficient in both 2-cell and 4-8-cell embryos from GM-fed mice than in controls. Although our results are still preliminary and limited to the pre-implantation phases, the results of this study encourage deepening on the effects of food components and/or contaminants on embryo development.
Cisterna, B; Flach, F; Vecchio, L; Barabino, S M L; Battistelli, S; Martin, T E; Malatesta, M; Biggiogera, M
2008-01-01
In eukaryotic cells, pre-mRNAs undergo several transformation steps to generate mature mRNAs. Recent studies have demonstrated that a diet containing a genetically modified (GM) soybean can induce modifications of nuclear constituents involved in RNA processing in some tissues of young, adult and old mice. On this basis, we have investigated the ultrastructural and immunocytochemical features of pre-implantation embryos from mice fed either GM or non- GM soybean in order to verify whether the parental diet can affect the morpho-functional development of the embryonic ribonucleoprotein structural constituents involved in pre-mRNA pathways. Morphological observations revealed that the general aspect of embryo nuclear components is similar in the two experimental groups. However, immunocytochemical and in situ hybridization results suggest a temporary decrease of pre-mRNA transcription and splicing in 2-cell embryos and a resumption in 4-8-cell embryos from mice fed GM soybean; moreover, pre-mRNA maturation seems to be less efficient in both 2-cell and 4-8-cell embryos from GM-fed mice than in controls. Although our results are still preliminary and limited to the pre-implantation phases, the results of this study encourage deepening on the effects of food components and/or contaminants on embryo development.
Archaeogeophysical investigations in Tiwanaku: preliminary results
Masini, Nicola; Sileo, Maria; Lasaponara, Rosa; Leucci, Giovanni; Orefici, Giuseppe; Rizzo, Enzo
2017-04-01
-1450) Tiwanaku was characterized by the resurgence of regional identities and polities In spite of the rich archaeological record numerous issues, related to the function and the extension of Tiwanaku, need to be investigated especially in the monumental core which includes the pyramid of Akapana, and other ceremonial places such Kalasasaya, Putuni and Kantatallita. To this aims some geophysical investigations were performed in 2009 and 2014 in the context of multidisciplinary research including the use of satellite remote sensing [8]. This paper deals with the discussion of preliminary results of geomagnetic and GPR investigations, some of which have been verified by trial archaeological excavations which have unearthed some buried structures, improving the knowledge of the ceremonial areas of Tiwanaku. References [1] Lasaponara R., Leucci G., Masini N., Persico R., Scardozzi G., Towards an operative use of remote sensing for exploring the past using satellite data: The case study of Hierapolis (Turkey), Remote sensing of Environment, 174 (2016) : 148-164, doi:10.1016/j.rse.2015.12.016 [2] Masini N., Lasaponara R., Rizzo E., Orefici G. 2012. Integrated Remote Sensing Approach in Cahuachi (Peru): Studies and Results of the ITACA Mission (2007-2010), In: Lasaponara R., Masini N. (Eds) 2012, Satellite Remote Sensing: a new tool for Archaeology, Springer, Verlag Berlin Heidelberg, ISBN 978-90-481-8800-0, doi: 10.1007/978-90-481-8801-7_14; pp. 307-344 [3] Rizzo E., Masini N., Lasaponara R., Orefici G. 2010, ArchaeoGeophysical methods in the Templo del Escalonado (Cahuachi, Nasca, Perù), Near Surface Geophysics 8 (5), 433-439, doi:10.3997/1873-0604.2010030 [4] Masini N., Rizzo E., Lasaponara R., and Orefici G. 2008, Integrated remote sensing techniques for the detection of buried archaeological adobe structures: preliminary results in Cahuachi (Peru), Advances in Geosciences, 19, 75-82 [5] Lasaponara R., Leucci G., Masini N., Persico R. 2014. Investigating archaeological looting
Preliminary results on the cryogenic target for FIREX project
International Nuclear Information System (INIS)
Iwamoto, A.; Maekawa, R.; Mito, T.; Okamoto, M.; Motojima, O.; Nakai, M.; Norimatsu, T.; Nagai, K.
2006-01-01
Preliminary tests on the cryogenic target for the fast ignition realization experiment (FIREX) project has been conducted. A foam shell method is proposed to realize its target design. A foam target consists of three parts: a foam shell, a conical laser guide and a liquid or gas feeder made of glass. The shell is a hollow sphere (500 μm in diameter) with a uniform and thin foam layer (about 20 μm in thickness). Epoxy resin is utilized to assemble the parts into the target. Liquid fuel is fed into the shell by the feeder and is soaked up by the foam material through capillarity. The fuel is then solidified. Regarding target fabrication, one of the concerns is the influence on various thermal contractions from the different materials when it is cooled down to cryogenic environment. This paper describes the result on the validity check at cryogenic environment and the demonstration of H 2 liquefaction using a dummy target instead of the foam target. Judging from these results, the target assembled in the same process as the dummy target is sure to be practicable for the FIREX project. (authors)
WISE/NEOWISE OBSERVATIONS OF THE JOVIAN TROJANS: PRELIMINARY RESULTS
International Nuclear Information System (INIS)
Grav, T.; Mainzer, A. K.; Bauer, J.; Masiero, J.; Eisenhardt, P. R. M.; Blauvelt, E.; DeBaun, E.; Elsbury, D.; Gautier, T. IV; Gomillion, S.; Hand, E.; Wilkins, A.; Spahr, T.; McMillan, R. S.; Walker, R.; Cutri, R.; Wright, E.
2011-01-01
We present the preliminary analysis of over 1739 known and 349 candidate Jovian Trojans observed by the NEOWISE component of the Wide-field Infrared Survey Explorer (WISE). With this survey the available diameters, albedos, and beaming parameters for the Jovian Trojans have been increased by more than an order of magnitude compared to previous surveys. We find that the Jovian Trojan population is very homogenous for sizes larger than ∼10 km (close to the detection limit of WISE for these objects). The observed sample consists almost exclusively of low albedo objects, having a mean albedo value of 0.07 ± 0.03. The beaming parameter was also derived for a large fraction of the observed sample, and it is also very homogenous with an observed mean value of 0.88 ± 0.13. Preliminary debiasing of the survey shows that our observed sample is consistent with the leading cloud containing more objects than the trailing cloud. We estimate the fraction to be N(leading)/N(trailing) ∼ 1.4 ± 0.2, lower than the 1.6 ± 0.1 value derived by Szabó et al.
International Nuclear Information System (INIS)
McDonald, V.; Phillips, R.S.
1978-01-01
Thymectomized NIH and C57BL mice were more susceptible to Plasmodium chabaudi than controls, indicating a role for T cells in acquired immunity to the parasite. Enriched populations of T and B cells were prepared from the spleens of immune mice using nylon-wool columns, and were adoptively transferred to syngeneic non-irradiated mice or mice irradiated with 600 or 800 rad. Some immunity could usually be transferred with immune T, B and glass-wool (g.w.) filtered spleen cell populations. In the heavily irradiated mice g.w. filtered immune spleen cells gave the best protection and the immune T cells the least. Preliminary attempts to show synergistic activity between immune T and B cells in irradiated mice were not successful. (author)
Preliminary results on ocean dynamics from Skylab and their implications for future spacecraft
Hayes, J.; Pierson, W. J.; Cardone, V. J.
1975-01-01
The instrument aboard Skylab designated S193 - a combined passive and active microwave radar system acting as a radiometer, scatterometer, and altimeter - is used to measure the surface vector wind speeds in the planetary boundary layer over the oceans. Preliminary results corroborate the hypothesis that sea surface winds in the planetary boundary layer can be determined from satellite data. Future spacecraft plans for measuring a geoid with an accuracy up to 10 cm are discussed.
2013-05-30
... From the People's Republic of China; Preliminary Results of Antidumping Duty New Shipper Review; 2011... duty order on multilayered wood flooring (``MLWF'') from the People's Republic of China (``PRC''). The period of review (``POR'') is May 26, 2011 through May 31, 2012. The review covers one exporter of...
Litvinova, Karina S.; Ahmad, Shakil; Wang, Keqing; Rafailov, Ilya E.; Sokolovski, Sergei G.; Zhang, Lin; Rafailov, Edik U.; Ahmed, Asif
2016-02-01
Endothelial dysfunction is directly linked to preeclampsia, a maternal hypertensive condition that is life threating for both the mother and the baby. Epidemiological studies show that women with a history of pre-eclampsia have an elevated risk for cardiovascular disease. Here we report a new non-invasive diagnostic test for preeclampsia in mice that allows us to non-invasively assess the condition of the animals during the experiment and treatment in established models of preeclampsia. A laser-based multifunctional diagnostics system (LAKK-M) was chosen to carry out non-invasive analysis of multiple parameters. The device was used to simultaneously record the microcirculatory blood flow and oxygen saturation, as well as fluorescence levels of endogenous fluorophores. Preliminary experiments were conducted on adenoviral (Ad-)- mediated overexpression of sFlt-1 (Ad-sFlt-1) to mimic preeclampsialike symptoms in mice. The recorded data displayed the ability of the LAKK-M diagnostics device to detect significant differences in perfusion measurements between the control and Ad-sFlt-1 treatment. Preliminary results provide a potential avenue to employ these diagnostics technology to monitor and aid in maintaining control of live animal conditions throughout the experiment and treatment.
Preliminary Results from Second Phase Sea Testing of the Wave Dragon Prototype Wave Energy Converter
DEFF Research Database (Denmark)
Soerensen, Hans Chr.; Tedd, James; Friis-Madsen, Erik
2006-01-01
In March 2006 the prototype Wave Dragon has been redeployed to a more energetic site in Nissum Bredning an inland sea in Western Denmark. This has followed a period of renovation of many aspects of the device which have resulted in 20% higher energy output. This paper describes the preliminary...
2011-05-06
... DEPARTMENT OF COMMERCE International Trade Administration [A-549-821] Polyethylene Retail Carrier Bags From Thailand: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative...) initiated an administrative review of the antidumping duty order on polyethylene retail carrier bags from...
DETECTION OF Helicobacter pylori IN GASTRIC MUCOSA OF SHEEP: PRELIMINARY RESULTS
Directory of Open Access Journals (Sweden)
A. Rella
2013-02-01
Full Text Available Helicobacter pylori is an organism widespread in humans and sometimes responsible for serious illnesses. It has been hypothesized the existence of animal reservoirs, and that the infection route by H. pylori involves multiple pathways including food-borne transmission as the microorganism has been detected from sheep, goat and cow milk. This work reports the preliminary results of a survey conducted in order to investigate the presence of H. pylori in gastric mucosa of sheep slaughtered in Apulia region (Italy employing a Nested Polymerase Chain Reaction (Nested-PCR assay for the detection of the phosphoglucosamine mutase gene (glmM, as screening method followed by conventional bacteriological isolation. Out of the 50 gastric mucosa samples examined, 3 (6% resulted positive for the presence of glmMgene, but at this time no strains were isolated. The results deserve further investigations to asses the role of ruminants as possible reservoirs of H. pylori.
In vivo distribution of Mn-hematoporphyrin derivative in tumor bearing mice54
International Nuclear Information System (INIS)
Crone Escanye, M.C.; Anghilleri, L.T.; Robert, J.
1988-01-01
This paper presents results of preliminary studies of the in vivo uptake and biodistribution of manganese labbelled hematoporphyrin derivative (HpD). The results indicate that: (1) Mn-HpD 54 is crhomatographically very similar to HpD; (2) the tissue distribution of Mn-HpD 54 are overal compareble to that reported by other. Authors for C 14 -HpD and H 3 -HpD in tumor bearing mice. It seems therefore that maanganese labelled HpD for the non invasivequantitation of HpD concetration in tumor and normal tissues and may be hepful in assessing the potential usefulness of Mn-HpD in NMR imaging of living animals
Preliminary research results for parameter diagnostics of intense pulsed ion beams
International Nuclear Information System (INIS)
Yang Hailiang; Qiu Aici; Sun Jianfeng; He Xiaoping; Tang Junping; Wang Haiyang; Li Jingya; Ren Shuqing; Huang Jianjun; Zhang Jiasheng; Peng Jianchang; Ouyang Xiaoping; Zhang Guoguang; Li Hongyu
2004-01-01
The preliminary experimental results for parameter diagnostics of intense pulsed ion beams from the FLASH II accelerator were reported. The ion number of an intense pulsed ion beam were experimentally determined by monitoring delayed radioactivity from protons induced nuclear reactions in a 12 C target. The prompt γ-rays and diode Bremsstrahlung X-rays were measured with PIN semi-conductor detector and a ST401 plastic scintillator detector. The Bremsstrahlung distribution outside of the drift tube was detected with a thermoluminescent detector and the shielding design was also determined. The current densities of beam were measured with biased ion collector array. The ion beams were also recorded with a CR-39 detector. (author)
Preliminary results in double cusp tandem mirror MM-4U
International Nuclear Information System (INIS)
Ming Linzhou; Tian Zhongyu; Feng Xiaozhen
1990-10-01
MM-4U device and preliminary experimental results are presented. Main results are as follows: The plasma has been produced by means of the injection of strong electron current; the axial profile of the plasma potential and the plasma electron density have been obtained respectively, they had a simular form; the plasma potential in the centre of the east cusp, the west cusp and the simple mirror; V e = -180V, V w = -164V, V m -1.8V; the electron density: n e = 1.7 x 10 11 cm -3 , n w = 4.7 x 10 10 cm -3 , n m = 7.5 x 10 7 cm -3 ; the electron temperature: T e = (19.9 ± 1.6) eV, T w = (20.7 ± 1.7) eV; the plasma pressure at 8 cm on the right of the west cusp centre is about 6.76 Pa, β ≅ 1.7 x 10 -3 . The plasma instability has been observed in the simple mirror, its vibration frequency was 7∼9.2 kHz. The results are discussed. The next new task of the physical experiment are proposed
New large solar photocatalytic plant: set-up and preliminary results.
Malato, S; Blanco, J; Vidal, A; Fernández, P; Cáceres, J; Trincado, P; Oliveira, J C; Vincent, M
2002-04-01
A European industrial consortium called SOLARDETOX has been created as the result of an EC-DGXII BRITE-EURAM-III-financed project on solar photocatalytic detoxification of water. The project objective was to develop a simple, efficient and commercially competitive water-treatment technology, based on compound parabolic collectors (CPCs) solar collectors and TiO2 photocatalysis, to make possible easy design and installation. The design, set-up and preliminary results of the main project deliverable, the first European industrial solar detoxification treatment plant, is presented. This plant has been designed for the batch treatment of 2 m3 of water with a 100 m2 collector-aperture area and aqueous aerated suspensions of polycrystalline TiO2 irradiated by sunlight. Fully automatic control reduces operation and maintenance manpower. Plant behaviour has been compared (using dichloroacetic acid and cyanide at 50 mg l(-1) initial concentration as model compounds) with the small CPC pilot plants installed at the Plataforma Solar de Almería several years ago. The first results with high-content cyanide (1 g l(-1)) waste water are presented and plant treatment capacity is calculated.
Frequent antibody production against RARalpha in both APL mice and patients.
Robin, Marie; Andreu-Gallien, Juliette; Schlageter, Marie-Helene; Bengoufa, Djaouida; Guillemot, Isabelle; Pokorna, Katerina; Robert, Carine; Larghero, Jerome; Rousselot, Philippe; Raffoux, Emmanuel; Dombret, Herve; Fenaux, Pierre; Pla, Marika; Charron, Dominique; Padua, Rose-Ann; Chomienne, Christine
2006-09-15
In an acute promyelocytic leukemia (APL)-transplantable mouse model, we previously reported the presence of antibodies recognizing PML-RARalpha and RARalpha in the sera of ATRA-treated mice. To evaluate this immune response, we determined the prevalence of anti-RARalpha antibodies in a cohort of 48 APL mice, treated by ATRA (n = 24) or by placebo pellets (n = 24), and in a preliminary subset of 9 patients with APL using a specific enzyme-linked immunosorbent assay (ELISA). In APL mice, significantly higher antibody levels were observed at the latest time points (day 48 to 58 levels superior to day 15 to 18 or day 28 to 38 levels). Antibody levels were higher in ATRA-treated mice than in placebo-treated mice and were also predictive of better survival. In the patients with APL, anti-RARalpha antibodies were detected at diagnosis and after maintenance therapy, reminiscent of the ATRA-treated APL mice. Antinuclear or antineutrophil cytoplasmic autoantibodies were also detected. These data reveal for the first time that in patients with APL an immune response may be detected at diagnosis and enhanced after maintenance therapy.
The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study
DEFF Research Database (Denmark)
Esbjørn, Barbara Hoff; Breinholst, Sonja; Reinholdt-Dunne, Marie Louise
2011-01-01
Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada....
2010-05-07
... polyethylene retail carrier bags from Malaysia for the period August 1, 2008, through July 31, 2009. See... DEPARTMENT OF COMMERCE International Trade Administration A-557-813 Polyethylene Retail Carrier Bags From Malaysia: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative...
Results of the Preliminary Test in the 1/4-Scale RCCS of the PMR200 VHTR
Energy Technology Data Exchange (ETDEWEB)
Kim, Jong-Hwan; Bae, Yoon-Yeong; Hong, Sung-Deok; Kim, Chan-Soo; Cho, Bong-Hyun; Kim, Min-Hwan [Nuclear Hydrogen Reactor Technology Development Dep., Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)
2014-10-15
The Reactor Cavity Cooling System (RCCS) is a key ex-vessel passive safety system that will ensure the safety of the PMR200, and its performance needs to be verified. For the difficulty of the full-scale test, a 1/4-scale RCCS facility, NACEF (Natural Cooling Experimental Facility), has been constructed at KAERI, and a shakedown test has been performed. A brief design and the preliminary test results of this facility are described. A 1/4-scale RCCS mockup of PMR200, NACEF, was constructed and tested preliminarily. The functioning of the facility worked quite well. Moreover, the preliminary test results show a fairly good agreement with past work except for the conductive heat transfer region in the riser bottom. After a remedy such as the installation of more precise flow meters and a more improved insulation, the test facility is likely to work well.
Precise Hypocenter Determination around Palu Koro Fault: a Preliminary Results
Fawzy Ismullah, M. Muhammad; Nugraha, Andri Dian; Ramdhan, Mohamad; Wandono
2017-04-01
Sulawesi area is located in complex tectonic pattern. High seismicity activity in the middle of Sulawesi is related to Palu Koro fault (PKF). In this study, we determined precise hypocenter around PKF by applying double-difference method. We attempt to investigate of the seismicity rate, geometry of the fault and distribution of focus depth around PKF. We first re-pick P-and S-wave arrival time of the PKF events to determine the initial hypocenter location using Hypoellipse method through updated 1-D seismic velocity. Later on, we relocated the earthquake event using double-difference method. Our preliminary results show the distribution of relocated events are located around PKF and have smaller residual time than the initial location. We will enhance the hypocenter location through updating of arrival time by applying waveform cross correlation method as input for double-difference relocation.
Preliminary Results of the Louisiana Sex Offender Treatment Program
Lee A. Underwood; Frances L.L. Dailey; Carrie Merino; Yolanda Crump
2015-01-01
The purpose of this study was to offer preliminary support for the Louisiana Sex Offender Treatment Program (LSOTP) in addressing the needs of juvenile sex offenders. Research objectives were (1) to offer statistical evidence for reductions in anxiety, depression, cognitive distortion and negative attitudes towards women comparing a group of 21 adolescents, 12 of whom received services as usual and nine of whom participated in the LSOTP. A controlled experimental evaluation design was utilize...
International Nuclear Information System (INIS)
Stoenescu, D.; Stefanescu, I.; Patularu, I.; Culcer, M.; Lazar, R.E.; Carcadea, E.; Mirica, D. . E-mail address of corresponding author: daniela@icsi.ro; Stoenescu, D.)
2005-01-01
It is well known that hydrogen is the most promising solution of future energy, both for long and medium term strategies. Hydrogen can be produced using many primary sources (natural gas, methane, biomass, etc.), it can be burned or chemically react having a high yield of energy conversion, being a non-polluted fuel. This paper presents the preliminary results obtained by ICSI Rm. Valcea in an experimental-demonstrative conversion energy system made by a sequence of hydrogen purification units and a CO removing reactors until a CO level lower than 10ppm, that finally feeds a hydrogen fuel stack. (author)
Head teacher professional networks in Italy: preliminary results of a national survey
Directory of Open Access Journals (Sweden)
Maurissens Isabel de
2016-06-01
Full Text Available In this article, we present the preliminary results of a national survey conducted by INDIRE on head teachers communities and professional networks. About one-fourth of the total population of Italian public school leaders participated in the survey. One of the main intents of this research is to contribute to understanding of the phenomenon of professional networks frequented by school leaders and to pave the way for a further reflection on how to use such networks for head teachers’ training so as to support their daily professional practice conducted too often in isolation.
Design and preliminary results of a fuel flexible industrial gas turbine combustor
Novick, A. S.; Troth, D. L.; Yacobucci, H. G.
1981-01-01
The design characteristics are presented of a fuel tolerant variable geometry staged air combustor using regenerative/convective cooling. The rich/quench/lean variable geometry combustor is designed to achieve low NO(x) emission from fuels containing fuel bound nitrogen. The physical size of the combustor was calculated for a can-annular combustion system with associated operating conditions for the Allison 570-K engine. Preliminary test results indicate that the concept has the potential to meet emission requirements at maximum continuous power operation. However, airflow sealing and improved fuel/air mixing are necessary to meet Department of Energy program goals.
Directory of Open Access Journals (Sweden)
Zydroń Tymoteusz
2016-03-01
Full Text Available Analysis of rainfall-induced shallow landslides in Jamne and Jaszcze stream valleys (Polish Carpathians - preliminary results. Preliminary shallow landslide susceptibility mapping of the Jamne and Jaszcze stream valleys, located in the Polish Flysch Carpathians, is presented in the paper. For the purpose of mapping, there were used SINMAP and Iverson’s models integrating infiltration and slope stability calculations. The calibration of the used models parameters, obtained from limited field and laboratory tests, was performed using data from 8-9 July 1997, when as a consequence of a very intense rainfall, 94 shallow landslides were observed on meadows and arable lands. A comparison of the slope stability calculation results and the localisation of the noticed shallow landslides showed satisfactory agreement between localisation of the observed and computed unstable areas. However, it was concluded that better simulation results were obtained using Iverson’s model.
Li, Xiaoli; Li, Yaqing; Han, Gaoyang; Li, Xiaoran; Ji, Yasai; Fan, Zhirui; Zhong, Yali; Cao, Jing; Zhao, Jing; Mariusz, Goscinski; Zhang, Mingzhi; Wen, Jianguo; Nesland, Jahn M.; Suo, Zhenhe
2016-01-01
Pyruvate plays a critical role in the mitochondrial tricarboxylic acid (TCA) cycle, and it is the center product for the synthesis of amino acids, carbohydrates and fatty acids. Pyruvate transported across the inner mitochondrial membrane appears to be essential in anabolic and catabolic intermediary metabolism. The mitochondrial pyruvate carrier (MPC) mounted in the inner membrane of mitochondria serves as the channel to facilitate pyruvate permeating. In mammals, the MPC is formed by two paralogous subunits, MPC1 and MPC2. It is known that complete ablation of MPC2 in mice causes death on the 11th or 12th day of the embryonic period. However, MPC1 deletion and the knowledge of gene function in vivo are lacking. Using the new technology of gene manipulation known as Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9 (CRISPR/Cas9) systems, we gained stable MPC1 gene heterozygous mutation mice models, and the heterozygous mutations could be stably maintained in their offsprings. Only one line with homozygous 27 bases deletion in the first exon was established, but no offsprings could be obtained after four months of mating experiments, indicating infertility of the mice with such homozygous deletion. The other line of MPC1 knockout (KO) mice was only heterozygous, which mutated in the first exon with a terminator shortly afterwards. These two lines of MPC1 KO mice showed lower fertility and significantly higher bodyweight in the females. We concluded that heterozygous MPC1 KO weakens fertility and influences the metabolism of glucose and fatty acid and bodyweight in mice. PMID:27835892
2013-01-11
... the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review and... Republic of China (``PRC''). The period of review (``POR'') is December 1, 2010, through November 30, 2011. The review covers one exporter of subject merchandise, Beijing Fila Dixon Stationery Company, Ltd. a...
2013-01-09
... People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012... on magnesium metal from the People's Republic of China (``PRC''). The period of review (``POR'') is April 1, 2011, through March 31, 2012. This review covers one PRC company, Tianjin Magnesium...
International Nuclear Information System (INIS)
Alexander, D.J.; Pawel, J.E.; Grossbeck, M.L.; Rowcliffe, A.F.
1993-01-01
Candidate materials for first wall/blanket structures in ITER have been irradiated to damage levels of about 3 dpa at temperatures of either 60 or 250 degrees C. Preliminary results have been obtained for several of these materials irradiated at 60 degrees C. The results show that irradiation at this temperature reduces the fracture toughness of austenitic stainless steels, but the toughness remains quite high. The unloading compliance technique developed for the subsize disk compact specimens works quite well, particularly for materials with lower toughness. Specimens of materials with very high toughness deform excessively, and this results in experimental difficulties
Directory of Open Access Journals (Sweden)
Kozhina OYu
2013-03-01
Full Text Available Now the task of preventive maintenance and search of biologically active substances, capable to make active the nonspecific immune response, remains an actual during flu epidemic. It has been previously established, that cryopreserved leucoconcentrate of human cord blood (cLHCB can act as modulator of activity of immunity. In the given work there was estimated influence of preventive injection of cLHCB and its components on functional activity of monocyte phagocytic system cells (MPSC in mice in the conditions of the induced influenzal infection. Preliminary introduction of cLHCB and its components 6 months prior to infection by flu virus makes 2 times increase of functional activity of macrophages, preventing inhibition of a nonspecific link of immunity. Thus, cLHCB inhibit of secondary immune deficiency development. The found increase in phagocytic activity of peritoneal cavity cells and 3 times increasesing of CD11b-marker expression after preventive injection of cLHCB testifies to rise of adherence and protective potential of MPSC that is one of possible mechanisms of formation of resistance to a flu virus. It is shown, that intranasal cLHCB injection before development of viral infection it can be o recommended as the method of preventive maintenance of flu.
Sealing a nuclear waste repository in Columbia river basalt: preliminary results
International Nuclear Information System (INIS)
Hodges, F.N.
1980-01-01
The long containment time required of repositories for nuclear waste (10 4 to 10 6 years) requires that materials used for repository seals be stable in the geologic environment of the repository and of proven longevity. A list of candidate materials for sealing a repository in Columbia River Basalts has been prepared and refined through laboratory testing. The most feasible techniques for emplacing preferred plug materials have been identified and the resultant plugs have been evaluated on the basis of design functions. Preconceptual designs for tunnel, shaft, and borehole seals consist of multiple zone plugs with each zone fulfilling one or more design functions. Zones of disturbed rock around tunnels and shafts, resulting from excavation and subsequent stress release, are zones of higher permeability and of possible fluid migration. In preliminary designs the disturbed zones are blocked by cut-off collars filled with low permeability materials
Preliminary results on a 4 kJ, 140 k A plasma focus
International Nuclear Information System (INIS)
Silva, Patricio; Favre, Mario; Chuaqui, Hernan; Wyndham, Edmund
1996-01-01
Preliminary results on the operation of a 4 kJ, 140 kA Plasma Focus device are presented. The machine operates Hydrogen and Hydrogen-Argon mixtures at pressures between 400 m Torr to 10 Torr. Main diagnostics include electric and current measurements, time and space resolved X-ray observations, with limited spectral resolution, and B-dot sensors to monitor the evolution of de current sheet during the run up phase of the discharge. The results indicate that good focus is obtained in the above pressure range. This is inferred from I-dot traces and Pin diode and pin-hole camera X-ray observations. The B-dot loops suggest that a symmetric current sheet is produced. These results show that the machine exhibits a reliable performance, which allows further studies on dense transient plasmas to be developed. (author)
Manning, B.; Gadd, C. S.
2001-01-01
Although published reports describe specific handheld computer applications in medical training, we know very little yet about how, and how well, handheld computing fits into the spectrum of information resources available for patient care and physician training. This paper reports preliminary quantitative and qualitative results from an evaluation study designed to track changes in computer usage patterns and computer-related attitudes before and after introduction of handheld computing. Pre...
Bowers, D T; Chhabra, P; Langman, L; Botchwey, E A; Brayman, K L
2011-11-01
Nanofiber scaffolds could improve islet transplant success by physically mimicking the shape of extracellular matrix and by acting as a drug-delivery vehicle. Scaffolds implanted in alternate transplant sites must be prevascularized or very quickly vascularized following transplantation to prevent hypoxia-induced islet necrosis. The local release of the S1P prodrug FTY720 induces diameter enlargement and increases in length density. The objective of this preliminary study was to evaluate length and diameter differences between diabetic and nondiabetic animals implanted with FTY720-containing electrospun scaffolds using intravital imaging of dorsal skinfold window chambers. Electrospun mats of randomly oriented fibers we created from polymer solutions of PLAGA (50:50 LA:GA) with and without FTY720 loaded at a ratio of 1:200 (FTY720:PLAGA by wt). The implanted fiber mats were 4 mm in diameter and ∼0.2 mm thick. Increases in length density and vessel diameter were assessed by automated analysis of images over 7 days in RAVE, a Matlab program. Image analysis of repeated measures of microvessel metrics demonstrated a significant increase in the length density from day 0 to day 7 in the moderately diabetic animals of this preliminary study (P < .05). Furthermore, significant differences in length density at day 0 and day 3 were found between recently STZ-induced moderately diabetic and nondiabetic animals in response to FTY720 local release (P < .05, Student t test). Driving the islet revascularization process using local release of factors, such as FTY720, from biodegradable polymers makes an attractive system for the improvement of islet transplant success. Preliminary study results suggest that a recently induced moderately diabetic state may potentiate the mechanism by which local release of FTY720 from polymer fibers increases length density of microvessels. Therefore, local release of S1P receptor-targeted drugs is under further investigation for improvement of
2012-12-10
... Refined Copper Pipe and Tube From Mexico and the People's Republic of China: Antidumping Duty Orders and... and Tube From Mexico: Preliminary Results of Antidumping Duty Administrative Review; 2010-2011 AGENCY... on seamless refined copper pipe and tube from Mexico. The review covers two producers/ exporters of...
2013-01-29
... the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review; 2011... antidumping duty order on laminated woven sacks (``sacks'') from the People's Republic of China (``PRC''). The period of review (``POR'') is August 1, 2011, through July 31, 2012. The review covers one exporter of...
High-resolution ultrasound biomicroscopy for monitoring ovarian structures in mice
Directory of Open Access Journals (Sweden)
Singh Jaswant
2009-07-01
Full Text Available Abstract Background Until recently, the limit of spatial resolution of ultrasound systems has prevented characterization of structures Methods Experiment 1 was a pilot study to develop methods of immobilization (physical restraint vs. general anesthesia and determine technical factors affecting ovarian images using ultrasound bio-microscopy in rats vs. mice. The hair coat was removed over the thoraco-lumber area using depilation cream, and a highly viscous acoustic gel was applied while the animals were maintained in sternal recumbency. In Experiment 2, changes in ovarian structures during the estrous cycle were monitored by twice daily ultrasonography in 10 mice for 2 estrous cycles. Results Ovarian images were not distinct in rats due to attenuation of ultrasound waves. Physical restraint, without general anesthesia, was insufficient for immobilization in mice. By placing the transducer face over the dorsal flank, the kidney was visualized initially as a point of reference. A routine of moving the transducer a few millimetres caudo-laterally from the kidney was established to quickly and consistently localize the ovaries; the total time to scan both ovaries in a mouse was about 10 minutes. By comparing vaginal cytology with non-anesthetized controls, repeated exposure to anesthesia did not affect the estrous cycle. Temporal changes in the number of follicles in 3 different size categories support the hypothesis that follicles ≥ 20 microns develop in a wave-like fashion. Conclusion The mouse is a suitable model for the study of ovarian dynamics using transcutaneous ultrasound bio-microscopy. Repeated general anesthesia for examination had no apparent effect on the estrous cycle, and preliminary results revealed a wave-like pattern of ovarian follicle development in mice.
Directory of Open Access Journals (Sweden)
Malak Kotb
2012-12-01
Full Text Available Countering aerosolized filovirus infection is a major priority of biodefense research. Aerosol models of filovirus infection have been developed in knock-out mice, guinea pigs and non-human primates; however, filovirus infection of immunocompetent mice by the aerosol route has not been reported. A murine model of aerosolized filovirus infection in mice should be useful for screening vaccine candidates and therapies. In this study, various strains of wild-type and immunocompromised mice were exposed to aerosolized wild-type (WT or mouse-adapted (MA Ebola virus (EBOV. Upon exposure to aerosolized WT-EBOV, BALB/c, C57BL/6 (B6, and DBA/2 (D2 mice were unaffected, but 100% of severe combined immunodeficiency (SCID and 90% of signal transducers and activators of transcription (Stat1 knock-out (KO mice became moribund between 7–9 days post-exposure (dpe. Exposure to MA-EBOV caused 15% body weight loss in BALB/c, but all mice recovered. In contrast, 10–30% lethality was observed in B6 and D2 mice exposed to aerosolized MA-EBOV, and 100% of SCID, Stat1 KO, interferon (IFN-γ KO and Perforin KO mice became moribund between 7–14 dpe. In order to identify wild-type, inbred, mouse strains in which exposure to aerosolized MA-EBOV is uniformly lethal, 60 BXD (C57BL/6 crossed with DBA/2 recombinant inbred (RI and advanced RI (ARI mouse strains were exposed to aerosolized MA-EBOV, and monitored for disease severity. A complete spectrum of disease severity was observed. All BXD strains lost weight but many recovered. However, infection was uniformly lethal within 7 to 12 days post-exposure in five BXD strains. Aerosol exposure of these five BXD strains to 10-fold less MA-EBOV resulted in lethality ranging from 0% in two strains to 90–100% lethality in two strains. Analysis of post-mortem tissue from BXD strains that became moribund and were euthanized at the lower dose of MA-EBOV, showed liver damage in all mice as well as lung lesions in
Uranium and thorium recovery in thorianite ore-preliminary results
Energy Technology Data Exchange (ETDEWEB)
Gaiotte, Joao V.M. [Universidade Federal de Alfenas, Pocos de Caldas, MG (Brazil); Villegas, Raul A.S.; Fukuma, Henrique T., E-mail: rvillegas@cnen.gov.br, E-mail: htfukuma@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Lab. de Pocos de Caldas
2011-07-01
This work presents the preliminary results of the studies aiming to develop a hydrometallurgical process to produce uranium and thorium concentrates from thorianite ore from Amapa State, Brazil. This process comprises two major parts: acid leaching and Th/U recovery using solvent extraction strategies. Thorianite ore has a typical composition of 60 - 70% of thorium, 8 - 10% lead and 7 - 10% uranium. Sulfuric acid leaching operational conditions were defined as follows: acid/ore ratio 7.5 t/t, ore size below 65 mesh (Tyler), 2 hours leaching time and temperature of 100 deg C. Leaching tests results showed that uranium and thorium recovery exceeded 95%, whereas 97% of lead ore content remained in the solid form. Uranium and thorium simultaneous solvent extraction is necessary due to high sulfate concentration in the liquor obtained from leaching, so the Primene JM-T primary anime was used for this extraction step. Aqueous raffinate from extraction containing sulfuric acid was recycled to the leaching step, reducing acid uptake around 60%, to achieve a net sulfuric acid consumption of 3 t/t of ore. Uranium and thorium simultaneous stripping was performed using sodium carbonate solution. In the aqueous stripped it was added sulfuric acid at pH 1.5, followed by a second solvent extraction step using the tertiary amine Alamine 336. The following stripping step was done with a solution of sodium chloride, resulting in a final solution of 23 g L-1 uranium. (author)
Preliminary results from the Chicago air shower array and the Michigan muon array
International Nuclear Information System (INIS)
Krimm, H.A.; Cronin, J.W.; Fick, B.E.; Gibbs, K.G.; Mascarenhas, N.C.; McKay, T.A.; Mueller, D.; Newport, B.J.; Ong, R.A.; Rosenberg, L.J.; Wiedenbeck, M.E.; Green, K.D.; Matthews, J.; Nitz, D.; Sinclair, D.; van der Velde, J.C.
1991-01-01
The Chicago Air Shower Array (CASA) is a large area surface array designed to detect extensive air showers (EAS) produced by primaries with energy ∼100 TeV. It operates in coincidence with the underground Michigan Muon Array (MIA). Preliminary results are presented from a search for steady emission and daily emission from three astrophysical sources: Cygnus X-3, Hercules X-1, and the Crab nebula and pulsar. There is no evidence for a significant signal from any of these sources in the 1989 data
International Nuclear Information System (INIS)
Castro, William J.; Squair, Peterson L.; Gonzaga, Natalia B.; Nogueira, Maria S.; Silva, Teogenes A. da
2009-01-01
The determination of the metrological characteristics of thermoluminescent (TL) dosimeters plays an important role in dosimetry of patients submitted to x-ray examinations for diagnostic purpose. Entrance surface doses can be measured with TL dosimeters to verify the compliance with the diagnostic reference levels. Organ doses can be estimated through TL measurements in an anthropomorphic phantom which it allows the radiation risk assessment. In this work, LiF:Mg,Ti (TLD-100) rod and chip thermoluminescent dosimeters were characterized considering their use for patient dosimetry in computerized tomography and mammography. Preliminary results showed that TL dosimeters have a response reproducibility of 7.8% and 4.8% and homogeneity of 18.4% and 6.5% for rod and chip shapes, respectively. (author)
Preliminary results on epidemiology of Coconut Lethal Yellowing in Ghana
Directory of Open Access Journals (Sweden)
Bonnot François
2009-03-01
Full Text Available Epidemiological studies are of major importance in understanding the determinants of plant diseases in order to control the risks of their spreading. A research programme on the epidemiology of coconut lethal yellowing, or Cape Saint Paul Wilt Disease (CSPWD, in Ghana was launched in March 2007. The objective was to characterize the distribution and spread of the disease in space and time at various scales, and their relation with the environment. This article presents the general strategy used to evaluate the incidence of CSPWD along with the environmental, ecological and agronomical variables at regional level. A survey was undertaken on 1,166 plots of Coconut Sector Development Project (CSDP planted with Malayan Yellow Dwarf (MYD × Vanuatu Tall (VTT hybrids in Western Region and Central Region. Preliminary results on the distribution of CSPWD and outside variables at regional scale, along with their relations, are given.
Head direction cell activity in mice: robust directional signal depends on intact otolith organs
Yoder, Ryan M.; Taube, Jeffrey S.
2009-01-01
The head direction (HD) cell signal is a representation of an animal's perceived directional heading with respect to its environment. This signal appears to originate in the vestibular system, which includes the semicircular canals and otolith organs. Preliminary studies indicate the semicircular canals provide a necessary component of the HD signal, but involvement of otolithic information in the HD signal has not been tested. The present study was designed to determine the otolithic contribution to the HD signal, as well as to compare HD cell activity of mice to that of rats. HD cell activity in the anterodorsal thalamus was assessed in wild-type C57BL/6J and otoconia-deficient tilted mice during locomotion within a cylinder containing a prominent visual landmark. HD cell firing properties in C57BL/6J mice were generally similar to those in rats. However, in C57BL/6J mice, landmark rotation failed to demonstrate dominant control of the HD signal in 36% of the sessions. In darkness, directional firing became unstable during 42% of the sessions, but landmark control was not associated with HD signal stability in darkness. HD cells were identified in tilted mice, but directional firing properties were not as robust as those of C57BL/6J mice. Most HD cells in tilted mice were controlled by landmark rotation, but showed substantial signal degradation across trials. These results support current models that suggest otolithic information is involved in the perception of directional heading. Furthermore, compared to rats, the HD signal in mice appears to be less reliably anchored to prominent environmental cues. PMID:19176815
2013-02-27
... People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012... administrative review of the antidumping duty order on silicon metal from the People's Republic of China (``PRC'') for the period of review (``POR'') June 1, 2011, through May 31, 2012. This review covers one PRC...
Tellurium in active volcanic environments: Preliminary results
Milazzo, Silvia; Calabrese, Sergio; D'Alessandro, Walter; Brusca, Lorenzo; Bellomo, Sergio; Parello, Francesco
2014-05-01
Tellurium is a toxic metalloid and, according to the Goldschmidt classification, a chalcophile element. In the last years its commercial importance has considerably increased because of its wide use in solar cells, thermoelectric and electronic devices of the last generation. Despite such large use, scientific knowledge about volcanogenic tellurium is very poor. Few previous authors report result of tellurium concentrations in volcanic plume, among with other trace metals. They recognize this element as volatile, concluding that volcanic gases and sulfur deposits are usually enriched with tellurium. Here, we present some results on tellurium concentrations in volcanic emissions (plume, fumaroles, ash leachates) and in environmental matrices (soils and plants) affected by volcanic emissions and/or deposition. Samples were collected at Etna and Vulcano (Italy), Turrialba (Costa Rica), Miyakejima, Aso, Asama (Japan), Mutnovsky (Kamchatka) at the crater rims by using common filtration techniques for aerosols (polytetrafluoroethylene filters). Filters were both eluted with Millipore water and acid microwave digested, and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Volcanic ashes emitted during explosive events on Etna and Copahue (Argentina) were analyzed for tellurium bulk composition and after leaching experiments to evaluate the soluble fraction of tellurium. Soils and leaves of vegetation were also sampled close to active volcanic vents (Etna, Vulcano, Nisyros, Nyiragongo, Turrialba, Gorely and Masaya) and investigated for tellurium contents. Preliminary results showed very high enrichments of tellurium in volcanic emissions comparing with other volatile elements like mercury, arsenic, thallium and bismuth. This suggests a primary transport in the volatile phase, probably in gaseous form (as also suggested by recent studies) and/or as soluble salts (halides and/or sulfates) adsorbed on the surface of particulate particles and ashes. First
Feasibility of Using Rice Hulls as Bedding for Laboratory Mice.
Carbone, Elizabeth T; Kass, Philip H; Evans, Kristin D
2016-01-01
Factors that are considered when selecting laboratory mouse bedding include animal health and comfort, cost, effects on personnel, and bioactive properties. Corncob is economical and facilitates low intracage ammonia but has undesirable influences on some endocrine studies. Rice hulls are an economical material that has not been well characterized as a bedding substrate. In this pilot study, we compared various aspects of bedding performance of rice hulls and other materials. On a per-volume basis, rice hulls were less absorbent than was corncob bedding. Rice hulls had higher odds than did corncob or reclaimed wood pulp of having moisture present at the bedding surface. The results of the absorbency tests coupled with the results of preliminary monitoring of intracage ammonia raised concern about the ability of rice hulls to control ammonia levels sufficiently in cages with high occupancy. However, ammonia was negligible when cages contained 5 young adult female mice. The relative expression of 3 cytochrome p450 genes was compared among mice housed on rice hulls, corncob, reclaimed wood pulp, or pine shavings. The expression of Cyp1a2 was 1.7 times higher in the livers of mice housed on rice hulls than on pine shavings, but other differences were not statistically significant. This study provides information on the merits of rice hulls as laboratory mouse bedding. Their relatively poor moisture control is a major disadvantage that might preclude their widespread use.
Traffics and wildlife: A preliminary study on road-kill
Rustiati, Elly Lestari
2012-01-01
This paper presents the preliminary finding on road kill survey by direct observations onthe high ways. The road-kills recorded of small wildlife, including medium size-mammal (2.50%, n =1), birds (5.00%, n = 2) and small mammals (92.50%, n = 37). The small mammals include the mostcommon mammals in the areas, squirrels, raccoons, skunks and woodchuck. Of mammals, squirrels(35.00%) were the highest recorded, followed by woodchucks (25.00%), mice/shrew (17.50%),raccoons (10.00%), skunk (5.00%) ...
Preliminary Results of Autotuning GEMM Kernels for the NVIDIA Kepler Architecture- GeForce GTX 680
Energy Technology Data Exchange (ETDEWEB)
Kurzak, Jakub [Univ. of Tennessee, Knoxville, TN (United States); Luszczek, Pitor [Univ. of Tennessee, Knoxville, TN (United States); Tomov, Stanimire [Univ. of Tennessee, Knoxville, TN (United States); Dongarra, Jack [Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Manchester (United Kingdom)
2012-04-01
Kepler is the newest GPU architecture from NVIDIA, and the GTX 680 is the first commercially available graphics card based on that architecture. Matrix multiplication is a canonical computational kernel, and often the main target of initial optimization efforts for a new chip. This article presents preliminary results of automatically tuning matrix multiplication kernels for the Kepler architecture using the GTX 680 card.
Development of a distress inventory for cancer: preliminary results.
Directory of Open Access Journals (Sweden)
Thomas B
2002-01-01
Full Text Available CONTEXT: Advances in cancer treatment have led to cure and prolongation of patients′ lives; however associated psychosocial problems, including distress, can detrimentally affect patients′ compliance with treatment and ultimately, their outcome. Symptom distress has been well addressed in many studies; however, psychological distress has only been quantified by using depression or anxiety scales/checklists or quality of life scales containing a distress sub scale/component or by the use of scales that are not psychological distress-specific. AIMS: The present study is an attempt to construct a psychological distress inventory for specific use with cancer patients. SETTINGS AND DESIGN: The standardisation sample consisted of 63 randomly selected patients with head and neck cancer who had undergone/ were undergoing curative treatment at the Regional Cancer Centre, Trivandrum. PATIENTS AND METHODS: The Distress Inventory for Cancer contained 57 positively and negatively toned items. An item analysis was conducted, followed by a factor analysis, thereby identifying the domains influencing distress. RESULTS: The final questionnaire contained 26 items subdivided into four domains viz. the personal, spiritual, physical, and the family domains, with each domain providing a sub score. The reliability coefficient (Cronbach′s alpha of the scale was found to be 0.85. CONCLUSIONS: These are the preliminary results of an ongoing study on global distress and tool development process. Reported here is the first step towards development of such tool.
Stokes polarimetry probe for skin lesion evaluation: preliminary results
Louie, Daniel C.; Tchvialeva, Lioudmilla; Kalia, Sunil; Lui, Harvey; Lee, Tim K.
2018-02-01
This paper reports on the design of a prototype in-vivo Stokes polarimetry probe for skin lesion evaluation, and preliminary results from skin phantom and clinical trials of this device. The probe releases a single millisecond-long pulse from a laser diode with either linear or circular polarization. It then captures the resulting backscattered far-field polarization speckle and calculates the Stokes parameters. This probe was designed with three novel innovations in mind. First, the Stokes vector is captured quickly, using low-cost components without the use of moving parts. Second, a compact collimated laser diode was used as the light source. Third, the device and detector geometry were designed to produce and capture a uniform speckle field. In the first clinical trial of this device, measurements were taken from a variety of skin lesions, both cancerous and benign. The Stokes vector was measured and used to calculate the degree of polarization (DOP), the azimuth angle, and the ellipticity angle of the polarization ellipse for two input light polarizations. Among other findings, the DOP for circular polarized input light was consistently lower than the DOP for linear polarized input light. These findings indicate the potential for a fast and low-cost in-vivo skin cancer screening tool, and encourages the continuing development of this probe's techniques.
Preliminary results from the U.S. participation in the 2000 Beam Park Experiment
Stansbery, Gene
2001-10-01
The United States participated in the 2000 Beam Park Experiment (BPE) conducted in late October, 2000 under the auspices of the Inter-Agency Space Debris Coordination Committee (IADC). The U.S. participated using several sensors which have participated in previous campaigns: Haystack, TRADEX, and COBRA DANE radars, and the Liquid Mirror Telescope. New to the BPE experiments this time are the GBR-P radar located at Kwajalein Atoll and the Haystack Auxiliary (HAX) radar located in Massachusetts. This paper will present and discuss preliminary results from each of the participating U.S. sensors.
Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons
Energy Technology Data Exchange (ETDEWEB)
Bodek, Arie [Univ. of Rochester, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)
2016-08-01
We present preliminary results on an experimental study of the nuclear modification of the longitudinal ($\\sigma_L$) and transverse ($\\sigma_T$) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= $\\sigma_L / \\sigma_T$ for nuclei ($R_A$) and for deuterium ($R_D$) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, $R_A< R_D$.
Preliminary results from a novel CVD diamond detector system for molecular imaging applications
International Nuclear Information System (INIS)
Mahon, A.R.
1996-01-01
A novel biomolecular imaging system incorporating a Chemical Vapour Deposition diamond detector is in development. The synthetic diamond is used as a UV detector to image nucleic acids in electrophoresis gels. The microstrip diamond detector currently has a spatial resolution of 30 μm. Preliminary results are presented which include: QE measurements of diamond detectors, detector time response, detector UV response and current detection limits of biomolecules in gel. The potential applications of the technology, and its significant advantages in speed and sensitivity over the current systems are discussed
ROUND-ROBIN ATOM-PROBE EXPERIMENT : PRELIMINARY RESULTS IN JAPAN
Nakamura , S.
1986-01-01
A round-robin experiment were to be carried out by 6 laboratories in Japan (Nishikawa ; Tokyo Inst. Tech., Sakurai and Igata ; Univ. of Tokyo, Ishikawa ; Hitachi, Tanino ; Nippon Steel Corp. and Nakamura ; Osaka Univ.) under the normal operating condition (T < l00 °K,. pulse fraction ~ 15% ~, P < 10-9 torr). Fe-Cr-Al and W-25%Re alloys, which are divided from a single wire were chosen as the specimen materials. A preliminary analysis of the W-Re alloy of the laboratory concerned show the good...
Use of the KineSpring system in the treatment of medial knee osteoarthritis: preliminary results.
Madonna, Vincenzo; Condello, Vincenzo; Piovan, Gianluca; Screpis, Daniele; Zorzi, Claudio
2015-01-01
the purpose of this study was to analyze our preliminary results obtained with the KineSpring system in patients suffering from medial compartment knee osteoarthritis (OA). between September 2012 and May 2014, 53 patients underwent treatment with the KineSpring system. Patient self-assessment was performed pre-operatively and at 3, 6 and 12 months postoperatively, and included the KOOS, Tegner activity score, Lysholm functional knee score, VAS knee pain score, and IKDC score. Device- and procedure-related adverse events were recorded. mean KOOS subscales, except for the Sport/Recreation subscale at six months, improved over time. Mean WOMAC Pain and Function domains, Lysholm score, IKDC score and VAS knee pain score improved over the follow-up period and were significantly improved at 3, 6 and 12 months postoperatively compared to baseline. Mean Tegner score improved slightly over time. In 5 of the 53 (9.4%) patients re-operation was necessary. In 3 patients the device was removed due to infection (one case) or persistent knee pain (two cases). Surgical arthrolysis was performed in two patients. in our preliminary experience, the KineSpring system gave good short-term clinical results. Level IV, therapeutic case series.
Directory of Open Access Journals (Sweden)
Michael L. Mann
2016-08-01
Full Text Available Unreliable electricity supplies are common in developing countries and impose large socio-economic costs, yet precise information on electricity reliability is typically unavailable. This paper presents preliminary results from a machine-learning approach for using satellite imagery of nighttime lights to develop estimates of electricity reliability for western India at a finer spatial scale. We use data from the Visible Infrared Imaging Radiometer Suite (VIIRS onboard the Suomi National Polar Partnership (SNPP satellite together with newly-available data from networked household voltage meters. Our results point to the possibilities of this approach as well as areas for refinement. With currently available training data, we find a limited ability to detect individual outages identified by household-level measurements of electricity voltage. This is likely due to the relatively small number of individual outages observed in our preliminary data. However, we find that the approach can estimate electricity reliability rates for individual locations fairly well, with the predicted versus actual regression yielding an R2 > 0.5. We also find that, despite the after midnight overpass time of the SNPP satellite, the reliability estimates derived are representative of daytime reliability.
Directory of Open Access Journals (Sweden)
Jan Vittek
2003-01-01
Full Text Available The contribution presents an extension of indirect vector control of electric drives employing induction motors to 'Forced Dynamic Control'. This method of control offers an accurate realisation of dynamic response profiles, which can be selected by the user. The developed system can be integrated into a drive with a shaft position encoder or a shaft sensoriess drive, in which only the stator currents are measured. The applied stator voltages are determined by a computed inverter switching algorithm. Simulation results and preliminary experimental results for indirect vector control of an idle running induction motor indicate good agreement with the theoretical predictions.
Preliminary results of the first paleontologic investigations in Uruguayan Antarctica
International Nuclear Information System (INIS)
Perea, D.; Masquelin, E.; Verde, M.; Querequiz, R.
1998-01-01
Preliminary results of the first Uruguayan paleontollogic and biostratigraphical investigations in Antartica are presented. The field work was performed in fildes Peninsula, King George Island, near Uruguayan station Base Cientifica Antarctica Artigas.Some fossiliferous outcrops were geologic and paleontologically analyzed, among them Fossil Hills, situated in the center part of the peninsula, in front of Ardley Island, between the chinese and chilean stations.This hill is composed of fossil bearing piroclastic and epiclastic rocks, assigned to the fossil Hill Fm. Vegetal remains(petrified wood and leaf impronts) were observed and collected in this unit and it is remarkable the presence of Nothofagus sp. and invertebrate trace fossils, Cochlichmus isp and Helminthopsis isp.The depositional environment deduced from the fossil association in lacustrine, under a warm and humid climate.In the same deposits, other investigators have collected aquatic and ratite bird trace fossils. Paleontologic evidence is not contradictory with the Eocene age previously proposed for the studied deposits. (author)
Raman scattering investigation of the water-bridge phenomenon: Some preliminary results
Directory of Open Access Journals (Sweden)
Francesco Aliotta
2010-09-01
Full Text Available A floating water-bridge is formed if a high-voltage direct current is applied between two beakers filled of chemically pure water. Raman spectra of the OH-stretching region have been obtained at ambient condition of temperature and pressure. These preliminary results seem to indicate that the hydrogen-bond structure is only slightly modified by the presence of the electric field applied to form the floating water-bridge in agreement with recent neutron scattering investigation. In fact, the polarized Raman spectrum of the pure water and of the water-bridge is almost superimposable. We are planning to carry out further spectroscopic analysis, at different thermodynamic conditions, for better understanding the role played by the hydrogen-bond in driving the formation of the floating water-bridge.
2010-12-17
... DEPARTMENT OF COMMERCE International Trade Administration [A-821-819] Magnesium Metal From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative... administrative review of the antidumping duty order on magnesium metal from the Russian Federation for the period...
2012-02-24
... DEPARTMENT OF COMMERCE International Trade Administration [C-489-806] Certain Pasta From Turkey: Extension of Time Limit for the Preliminary Results of the Countervailing Duty Administrative Review AGENCY... initiation of administrative review of the countervailing duty order on certain pasta from Turkey, covering...
2012-03-16
... DEPARTMENT OF COMMERCE International Trade Administration [C-475-819] Certain Pasta from Italy: Extension of Time Limit for the Preliminary Results of the Countervailing Duty Administrative Review AGENCY... notice of initiation of administrative review of the countervailing duty order on certain pasta from...
76 FR 6604 - Certain Pasta From Italy: Extension of Time Limit for the Preliminary Results of the...
2011-02-07
... DEPARTMENT OF COMMERCE International Trade Administration [C-475-819] Certain Pasta From Italy: Extension of Time Limit for the Preliminary Results of the Countervailing Duty Administrative Review AGENCY... initiation of administrative review of the countervailing duty order on certain pasta from Italy, covering...
2012-03-26
... DEPARTMENT OF COMMERCE International Trade Administration [A-821-801] Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review AGENCY... Commerce (the Department) initiated an administrative review of the antidumping duty order on solid urea...
2010-04-14
.... Hot-rolled dual phase steel, phase-hardened, primarily with a ferritic-martensitic microstructure.... See Preliminary Results of Antidumping Duty Administrative Review: Stainless Steel Sheet and Strip in... Antidumping Duty Administrative Review: Stainless Steel Sheet and Strip in Coils From France, 68 FR 69379...
2013-09-11
... DEPARTMENT OF COMMERCE International Trade Administration [A-552-801] Certain Frozen Fish Fillets... order on certain frozen fish fillets (``fish fillets'') from the Socialist Republic of Vietnam... preliminary results. \\1\\ See Notice of Antidumping Duty Order: Certain Frozen Fish Fillets From the Socialist...
2013-06-07
... Pipe and Tube Products From Turkey: Preliminary Results of Antidumping Duty Administrative Review; 2011... tube products (welded pipe and tube) from Turkey.\\2\\ The period of review is May 1, 2011, to April 30... A.S. (BMB) had reviewable sales during this period of review. DATES: As of June 7, 2013. FOR FURTHER...
Preliminary results from MBE-4: A four beam induction linac for heavy ion fusion research
International Nuclear Information System (INIS)
Fessenden, T.J.; Judd, D.L.; Keefe, D.; Kim, C.; Laslett, L.J.; Smith, L.; Warwick, A.I.; Warwick, P.b.A.I.
1986-01-01
Preliminary results are presented from a scaled experimental multiple beam induction linac. This experiment is part of a program of accelerator research for heavy ion fusion. It is shown that multiple beams can be accelerated without significant mutual interaction. Measurements of the longitudinal dynamics of a current-amplifying induction linac are presented and compared to calculations. Coupling of transverse and longitudinal dynamics is discussed
Preliminary results from MBE-4: a four beam induction linac for heavy ion fusion research
International Nuclear Information System (INIS)
Fessenden, T.J.; Judd, D.L.; Keefe, D.; Kim, C.; Laslett, L.J.; Smith, L.; Warwick, A.I.
1986-05-01
Preliminary results are presented from a scaled experimental multiple beam induction linac. This experiment is part of a program of accelerator research for heavy ion fusion. It is shown that multiple beams can be accelerated without significant mutual interaction. Measurements of the longitudinal dynamics of a current-amplifying induction linac are presented and compared to calculations. Coupling of transverse and longitudinal dynamics is discussed
Preliminary results about Electrodeposition of Cobalt at laboratory level
International Nuclear Information System (INIS)
Cornejo, N.
1992-01-01
As of an organic compound, an extraction and Cobalt electrodeposition method had been developed as a part of fabrication aim of a sealed radioactive source with objective to the construction of density meter prototype. It was performed preliminary test of electrodeposition in the laboratory level in a simple cell. The used electrolyte had been a sulphate solution obtained by extraction of an organic solution. It is obtained a Co film by electrodeposition at 55 o C temperature and with an approximately Co concentration in 70 g/lt. (Author) 3 refs., 1 fig., 1 tab
International Nuclear Information System (INIS)
Perdomo, Manuel
1995-01-01
Since 1990 the Group for PSA Development and Applications (GDA/APS) is working on the Level-1 PSA for the Juragua-1 NPP, as a part of an IAEA Technical Assistance Project. The main objective of this study, which is still under way, is to assess, in a preliminary way, the Reactor design safety to find its potential 'weak points' at the construction stage, using a eneric data base. At the same time, the study allows the PSA team to familiarize with the plant design and analysis techniques for the future operational PSA of the plant. This paper presents the most significant preliminary results of the study, which reveal some advantages of the safety characteristics of the plant design in comparison with the homologous VVER-440 reactors and some areas, where including slight modifications would improve the plant safety, considering the level of detail at which the study is carried out. (author). 13 refs, 1 fig, 2 tabs
2010-01-29
...-Quality Steel Plate Products From Italy: Preliminary Results of Antidumping Duty Administrative Review... administrative review of the antidumping duty order on certain cut-to-length carbon- quality steel plate products... that the Department conduct an administrative review of its sales and entries of subject merchandise...
2010-01-26
... DEPARTMENT OF COMMERCE International Trade Administration [A-351-825] Stainless Steel Bar From... antidumping duty order on certain stainless steel bar from Brazil for the period February 1, 2008, through... Steel Bar From Brazil: Extension of Time Limit for Preliminary Results of Antidumping Duty...
2012-02-27
... DEPARTMENT OF COMMERCE International Trade Administration [A-489-805] Certain Pasta From Turkey: Extension of Time Limit for the Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import... initiation of the administrative review of the antidumping duty order on certain pasta from Turkey, covering...
2010-12-27
... the People's Republic of China: Preliminary Results of the Second Administrative Review AGENCY: Import... laminated woven sacks (``LWS'') from the People's Republic of China (``PRC'') covering the period August 1, 2009, through July 31, 2010. This review covers imports of subject merchandise from one manufacturer...
2012-08-02
... granular magnesium'') from the People's Republic of China (``PRC'') with respect to one producer/ exporter... Form From the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review...-2012 Administrative Review of Pure Magnesium in Granular Form from the People's Republic of China...
2011-03-11
...'s Republic of China: Preliminary Results of the 2009-2010 Antidumping Duty Administrative Review... conducting an administrative review of the antidumping duty order on persulfates from the People's Republic... review covers one producer/exporter of the subject merchandise, i.e., United Initiators (Shanghai) Co...
2011-06-08
... assessment rates are above de minimis. We invite interested parties to comment on these preliminary results... Determination of Sales at Less Than Fair Value: Antidumping Duty Investigation of Pure Magnesium From the... the following alloying elements: aluminum, manganese, zinc, silicon, thorium, zirconium and rare...
2013-11-21
...\\ \\1\\ See Seamless Refined Copper Pipe and Tube From Mexico and the People's Republic of China... and Tube From the People's Republic of China: Preliminary Results and Partial Rescission of... China (``PRC''), covering the period November 1, 2011 through October 31, 2012. The Department has...
Rosenzweig, C.
2011-12-01
The Agricultural Model Intercomparison and Improvement Project (AgMIP) is a distributed climate-scenario simulation exercise for historical model intercomparison and future climate change conditions with participation of multiple crop and agricultural trade modeling groups around the world. The goals of AgMIP are to improve substantially the characterization of risk of hunger and world food security due to climate change and to enhance adaptation capacity in both developing and developed countries. Recent progress and the current status of AgMIP will be presented, highlighting three areas of activity: preliminary results from crop pilot studies, outcomes from regional workshops, and emerging scientific challenges. AgMIP crop modeling efforts are being led by pilot studies, which have been established for wheat, maize, rice, and sugarcane. These crop-specific initiatives have proven instrumental in testing and contributing to AgMIP protocols, as well as creating preliminary results for aggregation and input to agricultural trade models. Regional workshops are being held to encourage collaborations and set research activities in motion for key agricultural areas. The first of these workshops was hosted by Embrapa and UNICAMP and held in Campinas, Brazil. Outcomes from this meeting have informed crop modeling research activities within South America, AgMIP protocols, and future regional workshops. Several scientific challenges have emerged and are currently being addressed by AgMIP researchers. Areas of particular interest include geospatial weather generation, ensemble methods for climate scenarios and crop models, spatial aggregation of field-scale yields to regional and global production, and characterization of future changes in climate variability.
Recent improvements in the calculation of prompt fission neutron spectra: Preliminary results
International Nuclear Information System (INIS)
Madland, D.G.; LaBauve, R.J.; Nix, J.R.
1989-01-01
We consider three topics in the refinement and improvement of our original calculations of prompt fission neutron spectra. These are an improved calculation of the prompt fission neutron spectrum N(E) from the spontaneous fission of 252 Cf, a complete calculation of the prompt fission neutron spectrum matrix N(E,E n ) from the neutron-induced fission of 235 U, at incident neutron energies ranging from 0 to 15 MeV, and an assessment of the scission neutron component of the prompt fission neutron spectrum. Preliminary results will be presented and compared with experimental measurements and an evaluation. A suggestion is made for new integral cross section measurements. (author). 45 refs, 12 figs, 1 tab
Preliminary results for the helicity asymmetry E for eta photoproduction on the proton
International Nuclear Information System (INIS)
2012-01-01
Polarization observables are an important tool for clarifying the nucleon resonance spectrum. No previous measurements for double polarization asymmetries have been published for eta photoproduction. Double polarization measurements have been made at Jefferson Lab using a polarized photon beam and protons in a polarized frozen spin target (FROST). Data were taken during the first running period of FROST using the CLAS detector with photon energies from 0.33 to 2.35 GeV. Preliminary results for the E polarization observable for eta meson photoproduction from the proton at threshold and above, along with comparisons to several theoretical predictions are presented.
Postmortem study of stable carbon isotope ratios in human cerebellar DNA: preliminary results
International Nuclear Information System (INIS)
Slatkin, D.N.; Irsa, A.P.; Friedman, L.
1978-01-01
It is observed that 13 C/ 12 C ratios in tissue specimens removed postmortem in the United States and Canada are significantly different from corresponding ratios in European specimens. On the basis of this information, measurements of carbon isotope ratios in DNA isolated from cerebella of native-born and European-born North Americans are in progress with the goal of estimating the average lifetime rate of DNA turnover in human neurons. Preliminary results from twenty postmortem examinations are consistent with the hypothesis that a significant proportion of human cerebellar DNA is renewed during the lifetime of an individual
2011-03-29
... DEPARTMENT OF COMMERCE International Trade Administration [A-821-801] Solid Urea From the Russian Federation: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review AGENCY... administrative review of the antidumping duty order on solid urea from the Russian Federation for the period July...
2010-03-22
... Republic of China: Preliminary Results of the 2008-2009 Antidumping Duty Administrative Review AGENCY... administrative review of the antidumping duty order on saccharin from the People's Republic of China (``PRC'') covering the period July 1, 2008, through June 30, 2009. This administrative review covers one exporter of...
International Nuclear Information System (INIS)
Zhang Qingzhi; Wang Jia; Cheng Ying; Li Mingjuan; Min Rui
2010-01-01
In order to learn the effect of β-actin in acute radiation injury, the changeable pattern with time of plasma β-actin, PT, APTT, FIB and IL-8 in mice spleen tissue exposed to 6 Gy γ-rays radiation was investigated.Blood and spleen were collected at immediate, 1, 2, 3, 4, 7 and 14 d after irradiation, respectively. The contents of blood β-actin were detected by magnetic bead separation enzyme-linked immunosorbent. An STAGO blood coagulation instrument was used to determine PT, APTT and FIB. DNA expression of IL-8 was detected by real time-PCR analyzer. The results show that the level of β-actin in serum of irradiated mice is higher than that of normal control group at all different post-irradiation time points although the change of β-actin in serum of irradiated mice with time schedule shows a pattern which increases within 1d and declines beyond 1d. The trend of the changes in plasma PT, APTT, FIB and in spleen IL-8 and time pattern of these changes are similar to that in plasma β-actin in irradiated mice. The difference in values and the time phase between plasma β-actin and other indexes is the reaching time of peak values and the declining levels of the values. These results are valuable for studying the role of β-actin in acute radiation sickness pathology process and can be used to explore new factors influencing and regulating pathology process. (authors)
Preliminary results from initial in-pile debris bed experiments
International Nuclear Information System (INIS)
Rivard, J.B.
1977-01-01
An accident in a liquid metal fast breeder reactor (LMFBR) in which molten core material is suddenly quenched with subcooled liquid sodium could result in extensive fragmentation and dispersal of fuel as subcritical beds of frozen particulate debris within the reactor vessel. Since this debris will continue to generate power due to decay of retained fission products, containment of the debris is threatened if the generated heat is not removed. Therefore, the initial safety question is the capacity which debris beds may have for transfer of the decay heat to overlying liquid sodium by natural processes--i.e., without the aid of forced circulation of the coolant. Up to the present time, all experiments on debris bed behavior either have used substitute materials (e.g., sand and water) or have employed actual materials, but atypical heating methods. Increased confidence in the applicability of debris bed simulations is afforded if the heat is generated within the fuel component of the appropriate fast reactor materials. The initial series of in-pile tests reported on herein constitutes the first experiments in which the internal heating mode has been produced in particulate oxide fuel immersed in liquid sodium. Fission heating of the fully-enriched UO 2 in the experiment while it is contained within Sandia Laboratories Annular Core Pulse Reactor (ACPR), operating in its steady-state mode, approximates the decay heating of debris. Preliminary results are discussed
The Myres Hill remote sensing intercomparison study: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Clive, P J M; Chindurza, I [SgurrEnergy Ltd, 79 Coplaw Street, Glasgow G42 7JG, Scotland (United Kingdom); Ravey, I; Bass, J [RES Group Ltd, James Blyth House, 7000 Academy Park, Glasgow, Scotland (United Kingdom); Boyle, R J; Jones, P [TUV NEL Ltd, East Kilbride, Glasgow G75 0QF, Scotland (United Kingdom); Lang, S J [Sustainable Energy Research Group, University College Cork (Ireland); Bradley, S [Mighty River Power, Level 14, 23-29 Albert Street, Auckland (New Zealand); Hay, L [Garrad Hassan and Partners Ltd, 2064 Maryhill Road, Glasgow G20 0AB, Scotland (United Kingdom); Oldroyd, A [Oldbaum Services Ltd, Schoolhouse, Brig o' Turk, Callander, Scotland (United Kingdom); Stickland, M [University of Strathclyde, 16 Richmond Street, Glasgow G1 1XQ, Scotland (United Kingdom)], E-mail: peter.clive@sgurrenergy.com
2008-05-01
Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.
Seasonal comparison of trace metal residues in white-footed mice and soil from colliery stripmines
International Nuclear Information System (INIS)
Hausbeck, J.S.; Husby, M.P.; McBee, K.
1994-01-01
Mine tailings of abandoned coal stripmines in Oklahoma and other regions of the US have been shown to contain slightly elevated levels of copper (Cu) and zinc (Zn). Metalliferous stripmine spoil has been found to contain much higher levels of Cu and Zn than colliery stripmines, and many other trace metals including cadmium (Cd) and lead (Pb) among others. Although levels of trace metal contamination were lower for coal stripmines, research has shown small mammals exposed to low levels of trace metals may bioaccumulate trace metals. This study intended to determine the levels of Cd, Cu, Pb, and Zn in liver, kidney, and bone tissues of white-footed mice (Peromyscus leucopus) and examine the variance of these levels among sites and seasons. Preliminary results of soil analysis have indicated that mice collected from stripmine sites were exposed to slightly elevated levels of Zn and Cd in stripmine spoil collected from Okmulgee Co., OK. Kidney and liver tissues from mice collected at stripmine sites within this county have shown significantly greater levels of Cd and Zn than tissues collected from reference mice. Significant seasonal variation in renal and hepatic Zn concentrations was observed and possibly was related to a change in diet or reproductive activity
Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.
Directory of Open Access Journals (Sweden)
Xiang Yi Kong
Full Text Available Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1 has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver injury can cause metabolic dysregulation. Glmp gt/gt mice (formerly known as Ncu-g1gt/gt mice were studied between 3 weeks and 9 months of age. Body weight gain and feed efficiency of Glmp gt/gt mice were comparable to wild type siblings, only at the age of 9 months the Glmp gt/gt siblings had significantly reduced body weight. Reduced size of epididymal fat pads was accompanied by hepatosplenomegaly in Glmp gt/gt mice. Blood analysis revealed reduced levels of blood glucose, circulating triacylglycerol and non-esterified fatty acids in Glmp gt/gt mice. Increased flux of glucose, increased de novo lipogenesis and lipid accumulation were detected in Glmp gt/gt primary hepatocytes, as well as elevated triacylglycerol levels in Glmp gt/gt liver homogenates, compared to hepatocytes and liver from wild type mice. Gene expression analysis showed an increased expression of genes involved in fatty acid uptake and lipogenesis in Glmp gt/gt liver compared to wild type. Our findings are in agreement with the metabolic alterations observed in other mouse models lacking lysosomal proteins, and with alterations characteristic for advanced chronic liver injury.
Hybridization among wild boars, local breeds and commercial breeds - preliminary results
DEFF Research Database (Denmark)
Iacolina, Laura; Bakan, Jana; Cubric-Curik, Vlatka
. Hybridization with the domestic pig is known to occur in Europe, however the degree and extent of the phenomenon is not fully understood yet. Introgression is considered to be a treat to biodiversity and could lead to loss of local adaptation or introgression in the wild population of human selected genes....... A better understanding of the hybridization levels at European scale would provide an important tool for the development of management plans aimed at reducing human conflict but also at preserving biodiversity and genetic differentiation. Additionally, this information would provide new perspectives...... gradients in variability levels among the analysed wild and domestic populations. This preliminary results will be further investigated to address the possible presence of hybrid zone(s) in Europe and the possible implications for conservation and management of both wild populations and local pig breeds...
Preliminary results of the XR2-1 experiment
International Nuclear Information System (INIS)
Gauntt, R.O.; Helmick, P.H.; Humphries, L.
1996-01-01
The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools
International Nuclear Information System (INIS)
Strait, S.R.; Spane, F.A. Jr.
1982-11-01
This report presents preliminary results and description of hydrologic test activities for the composite Umtanum basalt flow top (3,568--3,781 feet) at Borehole RRL-2. Hydrologic tests conducted include two constant discharge air-lift and four slug tests. Preliminary results indicate an observed hydraulic head for the test interval of 405.7 feet above mean sea level. Transmissivity values determined from hydrologic tests performed, range between 244 to 481 ft 2 /day, with an assigned best estimate of 480 ft 2 /day. The best estimate of equivalent hydraulic conductivity, based on an effective test thickness of 157 feet, is 3.1 ft/day. 7 refs., 9 figs., 3 tabs
Preliminary Results from the PrimEx-II experiment at Jefferson Lab
Energy Technology Data Exchange (ETDEWEB)
Gasparian, Ashot [NCA& T, Greensboro, NC; Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)
2016-06-01
Properties of the neutral pion, as the lightest hadron in Nature, are most sensitive to the basic symmetries and their partial breaking effects in the theory of the strong interaction (QCD). In particular, the po →gg decay width is primarily defined by the spontaneous chiral symmetry breaking effect (chiral anomaly) in QCD. The next order corrections to the anomaly have been shown to be small and are known to a 1% precision level. The PrimEx Collaboration at JLab has developed and performed two Primakoff type experiments to measure the po →gg decay width with a similar precision. The published result from the PrimEx-I experiment, G(p0 →gg ) = 7.82±0.14 (stat.)±0.17 (syst.) eV, was a factor of two more precise than the average value quoted in PDG-2010 [1]. The second experiment was performed in 2010 with a goal of 1.4% total uncertainty to address the next-to-leading-order theory calculations. The preliminary results from the PrimEx-II experiment are presented and discussed in this note.
Preliminary results from a crowdsourcing experiment in immunohistochemistry.
Della Mea, Vincenzo; Maddalena, Eddy; Mizzaro, Stefano; Machin, Piernicola; Beltrami, Carlo A
2014-01-01
Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe the setup of an experimentation of crowdsourcing techniques applied to the quantification of immunohistochemistry. Fourteen Images from MIB1-stained breast specimens were first manually counted by a pathologist, then submitted to a crowdsourcing platform through a specifically developed application. 10 positivity evaluations for each image have been collected and summarized using their median. The positivity values have been then compared to the gold standard provided by the pathologist by means of Spearman correlation. Contributors were in total 28, and evaluated 4.64 images each on average. Spearman correlation between gold and crowdsourced positivity percentages is 0.946 (p crowdsourcing for an image analysis task that is currently time-consuming when done by human experts. Crowdsourced work can be used in various ways, in particular statistically agregating data to reduce identification errors. However, in this preliminary experimentation we just considered the most basic indicator, that is the median positivity percentage, which provided overall good results. This method might be more aimed to research than routine: when a large number of images are in need of ad-hoc evaluation, crowdsourcing may represent a quick answer to the need.
Corker, Kevin; Lebacqz, J. Victor (Technical Monitor)
1997-01-01
The NASA and the FAA have entered into a joint venture to explore, define, design and implement a new airspace management operating concept. The fundamental premise of that concept is that technologies and procedures need to be developed for flight deck and ground operations to improve the efficiency, the predictability, the flexibility and the safety of airspace management and operations. To that end NASA Ames has undertaken an initial development and exploration of "key concepts" in the free flight airspace management technology development. Human Factors issues in automation aiding design, coupled aiding systems between air and ground, communication protocols in distributed decision making, and analytic techniques for definition of concepts of airspace density and operator cognitive load have been undertaken. This paper reports the progress of these efforts, which are not intended to definitively solve the many evolving issues of design for future ATM systems, but to provide preliminary results to chart the parameters of performance and the topology of the analytic effort required. The preliminary research in provision of cockpit display of traffic information, dynamic density definition, distributed decision making, situation awareness models and human performance models is discussed as they focus on the theme of "design requirements".
Preliminary study of metabolic radiotherapy with 188Re via small animal imaging
International Nuclear Information System (INIS)
Antoccia, A.; Baldazzi, G.; Bello, M.
2006-01-01
188 Re is a β - (Emax=2.12 MeV) and γ (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, 99m Tc, molecules of hyaluronic acid (HA) have been labelled with 188 Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm 3 pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of 188 Re and with C57 black mice injected with the 188 Re-HA solution are presented. To increase the space resolution and to obtain two orthogonal projections simultaneously we are building in parallel two new cameras to be positioned at 90 degrees. They use a CsI(Tl) matrix with 1x1x5 mm 3 pixels read out by H8500 Hamamatsu Flat panel PMT
Preliminary dosimetric methodology for a new cobalt-60 irradiator for radioinduced necrosis
International Nuclear Information System (INIS)
Moura, Eduardo S.; Mosca, Rodrigo C.; Zeituni, Carlos A.; Rostelato, Maria Elisa C.M.; Mathor, Monica B.; Sakuraba, Roberto K.; Goncalves, Vinicius D.
2011-01-01
The use of ionizing radiation in medical procedures, as radiotherapy, is a well-established clinical process and it has been used for several decades with good clinical results and continuous technology development for treatment optimization. On the contrary, some injuries such as necrosis, may occur with patients, due to wrong administration of the absorbed dose or with expected side effects. To evaluate how these injuries could be investigated and how they can be treated, a new Cobalto-60 irradiator was developed to induce radionecrosis in mice. This irradiator is composed by a cylindrical size and it was set up with eleven Cobalt-60 sources aligned in the surface of a cylindrical lead. This alignment guarantees a small dose focal area in a longitudinal table, with proper frames for positioning mice precisely during the irradiations period. The dosimetric procedure will measure the absorbed dose in the dose focal area, delimited the area of irradiation with penumbra regions (gradients absorbed dose profiles) and others anatomical regions of the mice with high radiosensitivity. Possible dosimetric procedures and related devices will be present in this work,. The obtained dosimetric data will be applied to ensure the accurate period of radiation of a given position. This preliminary study assures that the fundamental dosimetric process of this new Cobalt-60 irradiator and it predicates that dosimetric processes area feasible to be conducted. (author)
Preliminary dosimetric methodology for a new cobalt-60 irradiator for radioinduced necrosis
Energy Technology Data Exchange (ETDEWEB)
Moura, Eduardo S.; Mosca, Rodrigo C.; Zeituni, Carlos A.; Rostelato, Maria Elisa C.M.; Mathor, Monica B., E-mail: esmoura@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Sakuraba, Roberto K.; Goncalves, Vinicius D. [Hospital Israelita Albert Einstein (HIAE), Sao Paulo, SP (Brazil)
2011-07-01
The use of ionizing radiation in medical procedures, as radiotherapy, is a well-established clinical process and it has been used for several decades with good clinical results and continuous technology development for treatment optimization. On the contrary, some injuries such as necrosis, may occur with patients, due to wrong administration of the absorbed dose or with expected side effects. To evaluate how these injuries could be investigated and how they can be treated, a new Cobalto-60 irradiator was developed to induce radionecrosis in mice. This irradiator is composed by a cylindrical size and it was set up with eleven Cobalt-60 sources aligned in the surface of a cylindrical lead. This alignment guarantees a small dose focal area in a longitudinal table, with proper frames for positioning mice precisely during the irradiations period. The dosimetric procedure will measure the absorbed dose in the dose focal area, delimited the area of irradiation with penumbra regions (gradients absorbed dose profiles) and others anatomical regions of the mice with high radiosensitivity. Possible dosimetric procedures and related devices will be present in this work,. The obtained dosimetric data will be applied to ensure the accurate period of radiation of a given position. This preliminary study assures that the fundamental dosimetric process of this new Cobalt-60 irradiator and it predicates that dosimetric processes area feasible to be conducted. (author)
Development of methods to measure hemoglobin adducts by gel electrophoresis - Preliminary results
International Nuclear Information System (INIS)
Sun, J.D.; McBride, S.M.
1988-01-01
Chemical adducts formed on blood hemoglobin may be a useful biomarker for assessing human exposures to these compounds. This paper reports preliminary results in the development of methods to measure such adducts that may be generally applicable for a wide variety of chemicals. Male F344/N rats were intraperitoneally injected with 14 C-BaP dissolved in corn oil. Twenty-four hours later, the rats were sacrificed. Blood samples were collected and globin was isolated. Globin protein was then cleaved into peptide fragments using cyanogen bromide and the fragments separated using 2-dimensional gel electrophoresis. The results showed that the adducted 14 C-globin fragments migrated to different areas of the gel than did unadducted fragments. Further research is being conducted to develop methods that will allow quantitation of separated adducted globin fragments from human blood samples without the use of a radiolabel. (author)
2012-12-10
... Thereof From the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review... Republic of China (``PRC''). The period of review (``POR'') is November 1, 2010 through October 31, 2011... have been calculated in accordance with section 772 of the Act. Because the PRC is a nonmarket economy...
2012-12-07
... Steel Pipe From the Republic of Korea: Preliminary Results of Antidumping Duty Administrative Review... antidumping duty order on circular welded non-alloy steel pipe (CWP) from the Republic of Korea (Korea). The... preliminarily found that one respondent has made sales of the subject merchandise at prices below normal value...
Results of preliminary experiments on tritium decontamination by UV irradiation
International Nuclear Information System (INIS)
Oya, Yasuhisa; Shu, Wataru; O'hira, Shigeru; Hayashi, Takumi; Nishi, Masataka
2000-03-01
In the point of view of protection of workers from the radiation exposure and the limitation of the contamination with radioactive materials, it is important to decontaminate mobile tritium from plasma facing components of a nuclear fusion reactor at the beginning of their maintenance work. It is considered that the heating is the most effective method for decontamination. However, it is important to develop new decontamination method of adsorbed hydro-carbon based substances from the materials that cannot be heated or the inner pipe of double pipes. This report presents results of preliminary experiments performed for the development of the effective tritium decontamination technique pursuing under US/Japan collaborative program on technology for fusion-fuel processing (Annex IV). In the experiments, the effects of Ultra Violet (UV) irradiation on tritium removal from some kinds of materials, such as poly vinyl chloride -(CH 2 CHCl) n - film, polyethylene film and graphite samples coated by C 2 H 2 plasma were examined. As the result of UV irradiation, it was confined that hydrogen and carbon based compounds could be released from the specimen during UV irradiation. It is concluded that UV irradiation is one of the hopeful candidates for effective tritium decontamination. (author)
IRIS PRA preliminary results and future direction
International Nuclear Information System (INIS)
Finnicum, D.J.; Kling, C.L.; Carelli, M.D.
2004-01-01
Westinghouse is currently conducting the pre-application licensing of the International Reactor Innovative and Secure (IRIS) on behalf of the IRIS Consortium. One of the key aspects of the IRIS design is the concept of safety-by-design. The PRA (Probabilistic Risk Analysis) is being used as an integral part of the design process. As part of this effort, a PRA of the initial design was generated to address 2 key areas. First, the IRIS PRA supported the evaluation of IRIS design issues by providing a solid risk basis for design and analyses required for the pre-licensing evaluation of the IRIS design. The PRA provides the tool for quantifying the benefit of the safety-by-design approach. Second, the current PRA task is beginning the preparation of the more complete PRA analyses and documentation eventually required for Design Certification. One of the key risk-related goals for IRIS is to reduce the EPZ (Emergency Protection Zone) to within the exclusion area by demonstrating that the off-site doses are consistent with the US Protective Action Guidelines (PAGs) for initiation of emergency response so that the required protective actions would be limited to the exclusion area. The results of the preliminary PRA indicated a core damage frequency of 1.2 E-08 for internal initiators. This is a very good result but much work is needed to meet the ambitious goal of no emergency response. The next phase of the PRA analyses will involve a two-fold expansion of the PRA. First, as the design and analyses approach a greater level of detail, the assumptions used for the initial PRA will be reviewed and the models will be revised as needed to reflect the improved knowledge of the system design and performance. Furthermore, as the full plant design advances, the PRA will be expanded to incorporate risk associated with external challenges such as seismic and fire, and to address low power and shutdowns modes of operation. As with the initial work, the PRA will serve as a tool to
A combination of preliminary results on gauge boson couplings measured by the LEP Experiments
CERN. Geneva
2004-01-01
This note presents a combination of published and preliminary measurements of triple gauge boson couplings (TGCs) and quartic gauge boson couplings (QGCs) from the four LEP experiments. We give an updated combination of the charged TGCs, g1z, kg and lg in single and multi-parameter fits. Updated results from the QGCs from the ZZgg vertex, ac/Lambda^2 and a0/Lambda^2, are given as well. The combinations of neutral TGCs hiv anf fiv are also presented, including an updated fiv combination.
Nras Overexpression Results in Granulocytosis, T-Cell Expansion and Early Lethality in Mice
DEFF Research Database (Denmark)
Lassen, Louise Berkhoudt; Gonzalez, Borja Ballarin; Schmitz, Alexander
2012-01-01
NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function ...... the increment in immature myeloid cells detected in these mice. The short latency period indicates that Nras overexpression alone is sufficient to cause dose-dependent granulocytosis and T-cell expansion....
Parker, L. N.; Zank, G. P.
2013-12-01
Successful forecasting of energetic particle events in space weather models require algorithms for correctly predicting the spectrum of ions accelerated from a background population of charged particles. We present preliminary results from a model that diffusively accelerates particles at multiple shocks. Our basic approach is related to box models (Protheroe and Stanev, 1998; Moraal and Axford, 1983; Ball and Kirk, 1992; Drury et al., 1999) in which a distribution of particles is diffusively accelerated inside the box while simultaneously experiencing decompression through adiabatic expansion and losses from the convection and diffusion of particles outside the box (Melrose and Pope, 1993; Zank et al., 2000). We adiabatically decompress the accelerated particle distribution between each shock by either the method explored in Melrose and Pope (1993) and Pope and Melrose (1994) or by the approach set forth in Zank et al. (2000) where we solve the transport equation by a method analogous to operator splitting. The second method incorporates the additional loss terms of convection and diffusion and allows for the use of a variable time between shocks. We use a maximum injection energy (Emax) appropriate for quasi-parallel and quasi-perpendicular shocks (Zank et al., 2000, 2006; Dosch and Shalchi, 2010) and provide a preliminary application of the diffusive acceleration of particles by multiple shocks with frequencies appropriate for solar maximum (i.e., a non-Markovian process).
Schröter, David; Matthews, Helen C.; Bogani, Debora; Moir, Lee; Long, Anna; Church, Christopher; Hugill, Alison; Anstee, Quentin M.; Goldin, Rob; Thursz, Mark; Hollfelder, Florian; Cox, Roger D.
2013-01-01
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes) died during embryonic development at 9.5–14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level. PMID:23826075
Directory of Open Access Journals (Sweden)
Michelle Goldsworthy
Full Text Available We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7 gene causes type 2 diabetes in the mouse. We have shown that mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease. Consistent with previous Mll2 knockout studies, mice homozygous for either ENU mutation (or compound heterozygotes died during embryonic development at 9.5-14.5 days post coitum. Heterozygous deletion of Mll2 induced in the adult mouse results in a normal phenotype suggesting that changes in chromatin methylation during development result in the adult phenotype. Mll2 has been shown to regulate a small subset of genes, a number of which Neurod1, Enpp1, Slc27a2, and Plcxd1 are downregulated in adult mutant mice. Our results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes, providing a basis for its further understanding at the molecular level.
Spatial and temporal variation of radiocarbon in tree rings - some preliminary results
International Nuclear Information System (INIS)
Higham, T.F.G.; Hogg, A.G.; McCormac, F.G.; Baillie, M.G.L.; Brown, D.; Palmer, J.G.; Xiong, L.
1997-01-01
A number of researchers have identified a measurable difference between the 14 C activities of tree rings of identical dendochronological age between the Northern and the Southern Hemispheres. It is also acknowledged that there is an urgent need for new high precision Δ 14 C data from tree rings in both Hemispheres to help resolve the questions relating to the magnitude and cause of the locality and temporal dependence of the Δ 14 C record, to provide a reliable Southern Hemisphere calibration curve and to throw light upon the 1986 and 1993 Calibration data set discrepancies. In this paper, the authors present the research design of a project to investigate these critical issues in radiocarbon age calibration and describe the preliminary results
International Nuclear Information System (INIS)
Jalilian, A.R.; Fateh, B.; Ghergherehchi, M.; Karimian, A.; Matloobi, M.; Moradkhani, S.; Kamalidehghan, M.; Tabeie, F.
2003-01-01
Backgrounds: Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [ 62 Zn] zinc chloride for oncologic PET studies. Materials and methods: The complex was obtained at the P H=2 normal saline at 90 d eg C in 60 min. Radio-TLC showed on overall radiochemical yield of 95-97% (radiochemical purity>97%). Stability of complex was checked in vitro in mice and human plasma/urine. Results: Preliminary in vitro studies performed to determined complex stability and distribution of [ 62 Zn] BLM in normal and fibrosarcoma tumors in mice according to bio-distribution/imaging studies. Conclusion: [ 62 Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical propertied as a diagnostic complex behavior in higher animals
A pancreas imaging agent-131I-HIPDM: the animal experiment and preliminary clinical application
International Nuclear Information System (INIS)
Shao Hesheng
1988-01-01
131 I-HIPDM has been used clinically for studying regional cerebral perfusion. The [ 131 I] HIPDM was prepared in a kit. The labelling yields were consistently more than 95%, as analyzed by the TLC-Silica gel. The labelled compound is stable in vitro and in vivo. S D Strain rats (170-220 g) and mice (18-22 g) were used. The pancreatic uptake of [ 131 I] HIPDM is rather slow in mice and rats. At 8 hr after iv, the pancreas activity and the pancreas to liver (P/L) ratio are highest in mice and rats. The effect of carrier loading dose from 0.010 to 6.0 mg/kg on blodistribution in mice has been studied. The liver uptake was increased by adding carrier HIPDM. The result indicates that administration between 0.010 and 0.05 mg/kg carrier dose is most suitable for the pancreas imaging. Gamma camera imaging of dog at 6 hr after iv with 300 μCi [ 131 I] HIPMD, 0.05 mg/kg body weight showed clear pancreas image. The P/L ratio of the dog is 0.40. Preliminary clinical tests were satisfactory. Using 1 to 1.5 mCi of [ 131 I] HIPDM, 0.05 mg/kg, the pancreas imaging was operated in 4 cases of volunteers and pancreas cyst respectively with the good diagnostic quality. The authors are of the opinion that this pancreas imaging agent may have potential value for routine use
Modelling lung cancer due to radon and smoking in WISMUT miners: Preliminary results
International Nuclear Information System (INIS)
Bijwaard, H.; Dekkers, F.; Van Dillen, T.
2011-01-01
A mechanistic two-stage carcinogenesis model has been applied to model lung-cancer mortality in the largest uranium-miner cohort available. Models with and without smoking action both fit the data well. As smoking information is largely missing from the cohort data, a method has been devised to project this information from a case-control study onto the cohort. Model calculations using 256 projections show that the method works well. Preliminary results show that if an explicit smoking action is absent in the model, this is compensated by the values of the baseline parameters. This indicates that in earlier studies performed without smoking information, the results obtained for the radiation parameters are still valid. More importantly, the inclusion of smoking-related parameters shows that these mainly influence the later stages of lung-cancer development. (authors)
2011-07-15
... DEPARTMENT OF COMMERCE International Trade Administration [A-570-831] Fresh Garlic From the People's Republic of China: Extension of Time Limit for Preliminary Results of Antidumping Duty... (``Department'') published a notice of initiation of an administrative review of fresh garlic from the People's...
2010-06-08
... DEPARTMENT OF COMMERCE International Trade Administration [A-570-831] Fresh Garlic From The People's Republic of China: Extension of Time Limit for Preliminary Results of Antidumping Duty... Commerce (``Department'') published a notice of initiation of an administrative review of fresh garlic from...
2011-10-21
... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of Antidumping Duty Administrative... antidumping duty order on certain orange juice from Brazil. See Initiation of Antidumping and Countervailing...
2010-11-16
... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From Brazil; Notice of Extension of Time Limits for Preliminary Results of Antidumping Duty Administrative... antidumping duty order on certain orange juice from Brazil. See Initiation of Antidumping and Countervailing...
Preliminary Results of 3D-DDTC Pixel Detectors for the ATLAS Upgrade
Energy Technology Data Exchange (ETDEWEB)
La Rosa, Alessandro; /CERN; Boscardin, M.; /Fond. Bruno Kessler, Povo; Dalla Betta, G.-F.; /Trento U. /INFN, Trento; Darbo, G.; Gemme, C.; /INFN, Genoa; Pernegger, H.; /CERN; Piemonte, C.; /Fond. Bruno Kessler, Povo; Povoli, M.; /Trento U. /INFN, Trento; Ronchin, S.; /Fond. Bruno Kessler, Povo; Zoboli, A.; /Trento U. /INFN, Trento; Zorzi, N.; /Fond. Bruno Kessler, Povo; Bolle, E.; /Oslo U.; Borri, M.; /INFN, Turin /Turin U.; Da Via, C.; /Manchester U.; Dong, S.; /SLAC; Fazio, S.; /Calabria U.; Grenier, P.; /SLAC; Grinstein, S.; /Barcelona, IFAE; Gjersdal, H.; /Oslo U.; Hansson, P.; /SLAC; Huegging, F.; /Bonn U. /SLAC /INFN, Turin /Turin U. /Oslo U. /Bergen U. /Oslo U. /Prague, Tech. U. /Bonn U. /SUNY, Stony Brook /Bonn U. /SLAC
2012-04-04
3D Silicon sensors fabricated at FBK-irst with the Double-side Double Type Column (DDTC) approach and columnar electrodes only partially etched through p-type substrates were tested in laboratory and in a 1.35 Tesla magnetic field with a 180 GeV pion beam at CERN SPS. The substrate thickness of the sensors is about 200 {mu}m, and different column depths are available, with overlaps between junction columns (etched from the front side) and ohmic columns (etched from the back side) in the range from 110 {mu}m to 150 {mu}m. The devices under test were bump bonded to the ATLAS Pixel readout chip (FEI3) at SELEX SI (Rome, Italy). We report leakage current and noise measurements, results of functional tests with Am{sup 241} {gamma}-ray sources, charge collection tests with Sr90 {beta}-source and an overview of preliminary results from the CERN beam test.
Economic evaluation of short-term wind power forecast in ERCOT. Preliminary results
Energy Technology Data Exchange (ETDEWEB)
Orwig, Kirsten D.; Hodge, Bri-Mathias; Brinkman, Greg; Ela, Erik; Milligan, Michael [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Banunarayanan, Venkat; Nasir, Saleh [ICF International, Fairfax, VA (United States); Freedman, Jeff [AWS Truepower, Albany, NY (United States)
2012-07-01
A number of wind energy integration studies have investigated the monetary value of using day-ahead wind power forecasts for grid operation decisions. Historically, these studies have shown that large cost savings could be gained by grid operators implementing the forecasts in their system operations. To date, none of these studies have investigated the value of shorter term (0- to 6-h ahead) wind power forecasts. In 2010, the Department of Energy and the National Oceanic and Atmospheric Administration partnered to form the Wind Forecasting Improvement Project (WFIP) to fund improvements in short-term wind forecasts and determine the economic value of these improvements to grid operators. In this work, we discuss the preliminary results of the economic benefit analysis portion of the WFIP for the Electric Reliability Council of Texas. The improvements seen in the wind forecasts are examined and the economic results of a production cost model simulation are analyzed. (orig.)
International Nuclear Information System (INIS)
Osorio, Ana Maria Araya; Saenz, Carlos Alberto Tello; Pereira, Luiz Augusto Stuani
2009-01-01
This work presents the preliminary results about the concentration of radon and radon daughters in wells and springs water from Presidente Prudente. Six water samples were studied: three from well-water, two from springs water and one from potable water. For the determination of α-activity the samples were placed inside plastic containers where the CR-39 tracks detectors were outside the water. The track density of α-particles were measured by using optical microscopy. The results show that one sample from well-water presented higher concentration of radon and radon daughters than the other samples. (author)
International Nuclear Information System (INIS)
Sharma, S.C.; Ninawe, N.G.; Yadav, M.L.; Ekambaram, M.; Ramjilal; Matkar, U.V.; Ansari, Q.N.; Lokare, R.N.; Ramlal; Gupta, A.K.; Bhagwat, P.V.; Pillay, R.G.
2009-01-01
The gas-stripper plays a key role in stripping the heavy and molecular ion beams in a tandem accelerator. Efficiency of gas stripper depends on its supporting vacuum pumps. A new recirculating turbo molecular pump-based gas stripper has been installed in the high voltage terminal of Pelletron Accelerator. Re-circulating the stripper gas reduces the flow of gas into the accelerating tubes reducing the transmission losses. Preliminary results obtained using the new gas stripper system are discussed. (author)
Stock Market Reaction to CEO Appointment – Preliminary Results
Directory of Open Access Journals (Sweden)
Katarzyna Byrka-Kita
2017-06-01
Full Text Available Purpose: The aim of this paper is to examine shareholders’ reaction to the decision of the supervisory board to appoint a CEO in companies listed on the Warsaw Stock Exchange. Methodology: An event study and the mean-adjusted model were applied. The abnormal returns were measured as the CAAR in the entire (-60, + 60 window and selected sub-windows. Findings: The obtained values of abnormal returns indicate the shareholder’s negative reaction. Throughout the observation window, they oscillate slightly below zero, and in the window (0, +20 they are negative at -1.566%. Irrespective of the observation window, negative abnormal returns were obtained for over half of the observation (52–57%. Therefore, preliminary results indicate the predominance of the information effect over the real one. The decrease in market value as a result of the event may result from an increase in investors’ uncertainty as to the effects of changes in strategy and skills of the new CEO. Originality: The research is a unique one. To date, no one has carried out research into shareholders’ reaction to a CEO appointment in either the Polish or Central and Eastern European capital markets. They primarily bring the value of cognition of shareholders’ behaviour in the analysed event, which is reflected in share prices. They extend the literature on the signalization instruments, i.e. the activities that boards can undertake due to the new information transmitted to the capital market participants and stakeholders. The market reaction to a CEO appointment will without a doubt interest investors; the institutions responsible for supervision (which in the case of Poland is the Financial Oversight Commission and the legislator in charge of regulations that prevent insider trading while promoting corporate disclosure transparency.
2010-10-25
... DEPARTMENT OF COMMERCE International Trade Administration [A-533-810] Stainless Steel Bar From India: Extension of Time Limit for the Preliminary Results of the Antidumping Duty Administrative Review... initiation of an administrative review of the antidumping duty order on stainless steel bar from India...
2012-02-28
... DEPARTMENT OF COMMERCE International Trade Administration [A-475-818] Certain Pasta From Italy: Extension of Time Limit for the Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import... notice of initiation of the administrative review of the antidumping duty order on certain pasta from...
International Nuclear Information System (INIS)
Bartzis, G.
1985-02-01
In this work a general description of the ADREA-I code is presented and some preliminary results are discussed. The ADREA-I is a transient three dimensional computer code aimed at transport analysis with particular emphasis on atmospheric dispersion under any realistic terrain conditions (complex or not) applicable to the planetary boundary layer in a distance extending up to a hundred kilometers or more. The complex geometry applications and the reasonable results obtained constitute a solid indication of the broad capability of the code. (author)
Spatial and temporal variation of radiocarbon in tree rings - some preliminary results
Energy Technology Data Exchange (ETDEWEB)
Higham, T.F.G.; Hogg, A.G. [Waikato Univ., Hamilton (New Zealand); McCormac, F.G.; Baillie, M.G.L.; Brown, D. [Queens`s University, Belfast, (Ireland). School of Geosciences; Palmer, J.G.; Xiong, L. [Lincoln University, Canterbury (New Zealand). Department of Plant Science
1997-12-31
A number of researchers have identified a measurable difference between the {sup 14}C activities of tree rings of identical dendochronological age between the Northern and the Southern Hemispheres. It is also acknowledged that there is an urgent need for new high precision {Delta}{sup 14}C data from tree rings in both Hemispheres to help resolve the questions relating to the magnitude and cause of the locality and temporal dependence of the {Delta}{sup 14}C record, to provide a reliable Southern Hemisphere calibration curve and to throw light upon the 1986 and 1993 Calibration data set discrepancies. In this paper, the authors present the research design of a project to investigate these critical issues in radiocarbon age calibration and describe the preliminary results. Paper no. 30; Extended abstract; 12 refs.
ACTPol: Status and preliminary CMB polarization results from the Atacama Cosmology Telescope
Koopman, Brian
2014-03-01
The Atacama Cosmology Telescope Polarimeter (ACTPol) is a polarization sensitive upgrade for the Atacama Cosmology Telescope, located at an elevation of 5190 m on Cerro Toco in Chile. In summer 2013, ACTPol achieved first light with one third of the final detector configuration. The remaining two thirds of the detector array will be installed during spring 2014, enabling full sensitivity, high resolution, observations at both 90 GHz and 150 GHz. Using approximately 3,000 transition-edge sensor bolometers, ACTPol will enable measurements of small angular scale polarization anisotropies in the Cosmic Microwave Background (CMB). I will present a status update for the ACTPol receiver and some preliminary results. ACTPol measurements will allow us to probe the spectral index of inflation as well as to constrain early dark energy and the sum of neutrino masses.
International Nuclear Information System (INIS)
Strait, S.R.; Spane, F.A. Jr.
1983-02-01
This report presents preliminary results and description of hydrologic test activities for the Umtanum Basalt Fracture Zone at Borehole RRL-2, within the test interval 3,781 to 3,827 feet. Hydrologic tests conducted include two short-term, constant discharge pumping tests and two slug tests. Preliminary results indicate an observed hydraulic head for the test interval of 406.7 feet above mean sea level. Transmissivity values determined from hydrologic tests performed range between 205 and 881 ft 2 /day. The best estimate of equivalent hydraulic conductivity, based on an effective test thickness of 6 feet, is 147 ft/day. 8 refs., 6 figs., 3 tabs
Struk, Peter; Tsao, Jen-Ching; Bartkus, Tadas
2017-01-01
This paper describes plans and preliminary results for using the NASA Propulsion Systems Lab (PSL) to experimentally study the fundamental physics of ice-crystal ice accretion. NASA is evaluating whether this facility, in addition to full-engine and motor-driven-rig tests, can be used for more fundamental ice-accretion studies that simulate the different mixed-phase icing conditions along the core flow passage of a turbo-fan engine compressor. The data from such fundamental accretion tests will be used to help develop and validate models of the accretion process. This paper presents data from some preliminary testing performed in May 2015 which examined how a mixed-phase cloud could be generated at PSL using evaporative cooling in a warmer-than-freezing environment.
Directory of Open Access Journals (Sweden)
S. N. Depamede
2011-12-01
Full Text Available Clostridium botulinum neurotoxin (BoNTs is one of the causes of economic loss in the livestock industry. This economic loss would be as a direct result when animals poisoned by BoNTs or indirectly when the livestock products are contaminated by BoNTs, which end up with the products are banned by authority. Therefore a routine surveillance of BoNTs in the farm and in livestock product processing industry is urgently needed. One of the most relatively quick and accurate methods to perform a routine detection of the presence of BoNTs is enzyme-linkage immunosorbant assay (ELISA. In this article we describe the results of the development of ELISA, using polyclonal antibodies against BoNTs-B produced locally. Antibodies were generated from six Balb/c mice with standard immunological methods. Mice were immunized three times for a period of 8 weeks with a commercial type B Clostridium botulinum toxoid at a dose of 100 ng per mouse per injection. The resulting antibody was purified by a combination of ammonium sulfate precipitation 50% (w/v technique and a protein A column method. The results of this preliminary study indicated that the developed ELISA method capable of detecting type B Clostridium botulinum toxin up to 1.0 ng/ml.
Spectral Monitoring of AGN: Preliminary Results for Ark 564 and Arp 102B
Directory of Open Access Journals (Sweden)
Shapovalova A. I.
2011-09-01
Full Text Available We present preliminary results of the long-term spectral monitoring of two active galactic nuclei with different broad line shapes: Ark 564 and Arp 102B. Ark 564 is a bright nearby narrow-line Syfert 1 (NLS1 galaxy with relatively narrow permitted optical emission lines and a high Fe II/Hβ ratio, while Arp 102B is a nearby broad-line radio galaxy with broad double-peaked Balmer emission lines. The spectra of Ark 564 were observed during 11-year period (1999-2009 and the spectra of Arp 102B in the 12-year period (1998-2009, with SAO 6 m and 1 m telescopes (Russia and the OAGH 2.1 m telescope (Cananea, Mexico.
Preliminary Results from Integrating Compton Photon Polarimetry in Hall A of Jefferson Lab
International Nuclear Information System (INIS)
Parno, D; Friend, M; Benmokhtar, F; Franklin, G; Quinn, B; Michaels, R; Nanda, S; Souder, P
2011-01-01
A wide range of nucleon and nuclear structure experiments in Jefferson Lab's Hall A require precise, continuous measurements of the polarization of the electron beam. In our Compton polarimeter, electrons are scattered off photons in a Fabry-Perot cavity; by measuring an asymmetry in the integrated signal of the scattered photons detected in a GSO crystal, we can make non-invasive, continuous measurements of the beam polarization. Our goal is to achieve 1% statistical error within two hours of running. We discuss the design and commissioning of an upgrade to this apparatus, and report preliminary results for experiments conducted at beam energies from 3.5 to 5.9 GeV and photon rates from 5 to 100 kHz.
Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation
Directory of Open Access Journals (Sweden)
Eun Kim
2016-11-01
Full Text Available Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E fused to the T4 fibritin foldon trimerization domain (Efl. The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA. The immunogenicity of these two vaccines, named Ad5.ZIKV-Efl and ZIKV-rEfl, was tested in C57BL/6 mice. Prime/boost immunization regimen was associated with induction of a ZIKV-specific antibody response, which provided neutralizing immunity. Moreover, protection was evaluated in seven-day-old pups after virulent ZIKV intraperitoneal challenge. Pups born to mice immunized with Ad5.ZIKV-Efl were all protected against lethal challenge infection without weight loss or neurological signs, while pups born to dams immunized with MNA-ZIKV-rEfl were partially protected (50%. No protection was seen in pups born to phosphate buffered saline-immunized mice. This study illustrates the preliminary efficacy of the E ZIKV antigen vaccination in controlling ZIKV infectivity, providing a promising candidate vaccine and antigen format for the prevention of Zika virus disease.
International Nuclear Information System (INIS)
Suzczynski, E.F.; Chatterjee, S.; Mueller, Arno
1982-01-01
The experimental methodology to evaluate the mechanical properties of ABNT 41xx and 86xx steels modified with NB in the as cast and heat treated conditions and the first preliminary results obtained in a laboratory scale, are presented. (Author) [pt
Skarra, Danalea V; Hernández-Carretero, Angelina; Rivera, Alissa J; Anvar, Arya R; Thackray, Varykina G
2017-09-01
Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic disorders, including type 2 diabetes and cardiovascular disease. We previously developed a model that uses letrozole to elevate endogenous testosterone levels in female mice. This model has hallmarks of PCOS, including hyperandrogenism, anovulation, and polycystic ovaries, as well as increased abdominal adiposity and glucose intolerance. In the current study, we further characterized the metabolic dysfunction that occurs after letrozole treatment to determine whether this model represents a PCOS-like metabolic phenotype. We focused on whether letrozole treatment results in altered pancreatic or liver function as well as insulin resistance. We also investigated whether hyperinsulinemia occurs secondary to weight gain and insulin resistance in this model or if it can occur independently. Our study demonstrated that letrozole-treated mice developed hyperinsulinemia after 1 week of treatment and without evidence of insulin resistance. After 2 weeks of letrozole treatment, mice became significantly heavier than placebo mice, demonstrating that weight gain was not required to develop hyperinsulinemia. After 5 weeks of letrozole treatment, mice exhibited blunted glucose-stimulated insulin secretion, insulin resistance, and impaired insulin-induced phosphorylation of AKT in skeletal muscle. Moreover, letrozole-treated mice exhibited dyslipidemia after 5 weeks of treatment but no evidence of hepatic disease. Our study demonstrated that the letrozole-induced PCOS mouse model exhibits multiple features of the metabolic dysregulation observed in obese, hyperandrogenic women with PCOS. This model will be useful for mechanistic studies investigating how hyperandrogenemia affects metabolism in females. Copyright © 2017 Endocrine Society.
MAAP4 CANDU analysis of a generic CANDU-6 plant: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Petoukhov, S.M.; Mathew, P.M
2001-10-01
To support the generic probabilistic safety analysis (PSA) program at AECL, in particular to conduct Level 2 PSA analysis of a CANDU 6 plant undergoing a postulated severe accident, the capability to conduct severe accident consequence analysis for a CANDU plant is required. For this purpose, AECL selected MAAP4 CANDU from a number of other severe accident codes. The necessary models for a generic CANDU 6 station have been implemented in the code, and the code version 0.2 beta was tested using station data, which were assembled for a generic CANDU 6 station. This paper describes the preliminary results of the consequence analysis using MAAP4 CANDU for a generic CANDU 6 station, when it undergoes a station blackout and a large loss-of-coolant accident scenario. The analysis results show that the plant response is consistent with the physical phenomena modeled and the failure criteria used. The results also confirm that the CANDU design is robust with respect to severe accidents, which is reflected in the calculated long times that are available for administering accident management measures to arrest the accident progression before the calandria vessel or containment become at risk. (author)
Preliminary results with the CLAMSUD pion spectrometer at the Moscow Meson Factory
International Nuclear Information System (INIS)
Badala, A.; Barbera, R.; Librizzi, F.; Longhitano, A.; Nicotra, D.; Palmeri, A.; Pappalardo, G.S.; Riggi, F.; Santoro, A.; Turrisi, R.; Aseev, V.; Feschenko, A.; Gavrilov, Yu.; Guber, F.; Golubeva, M.; Karavicheva, T.; Kurepin, A.; Ostroumov, P.; Potapov, V.; Tiflov, V.; Zhuravlev, A.
1995-01-01
A magnetic spectrometer has been recently installed at the new proton beam facility of the Moscow Meson Factory, to study charged pion production from proton-nucleus interactions at 200-400 MeV bombarding energy. Preliminary reults obtained during the first runs are reported. The planned physics program is also discussed. (orig.)
Preliminary Results on the Influence of Engineered Artificial Mucus Layer on Phonation
Döllinger, Michael; Gröhn, Franziska; Berry, David A.; Eysholdt, Ulrich; Luegmair, Georg
2014-01-01
Purpose: Previous studies have confirmed the influence of dehydration and an altered mucus (e.g., due to pathologies) on phonation. However, the underlying reasons for these influences are not fully understood. This study was a preliminary inquiry into the influences of mucus architecture and concentration on vocal fold oscillation. Method: Two…
Results of Preliminary Tests of PAR Bunch Cleaning
Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S
2005-01-01
A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10
2012-06-06
... Noksel did not make sales at less than normal value (NV) during the POR. If these preliminary results are... chromium, or 0.30 percent of cobalt, or 0.40 percent of lead, or 1.25 percent of nickel, or 0.30 percent of... questionnaire and 19 CFR 351.414(e)(2), Noksel requested that the reporting period for home market sales be...
The MACHO Project: Preliminary Results from 4 years of SMC observations.
Vandehei, T.; Griest, K.; Lehner, M.; Alcock, C.; Alves, D.; Cook, K.; Marshall, S.; Minniti, D.; Allsman, R.; Axelrod, T.; Freeman, K.; Peterson, B.; Rodgers, A.; Pratt, M.; Becker, A.; Stubbs, C.; Tomaney, A.; Bennett, D.; Quinn, P.; Sutherland, W.; Welch, D.
1997-12-01
The MACHO project is a search for dark matter in the form of massive compact halo objects(MACHOs). The project has photometrically monitored tens of millions of stars in the Large Magellanic Cloud (LMC), Small Magellanic Cloud (SMC), and Galactic bulge in search of rare gravitational microlensing events caused by these otherwise invisible objects. Microlensing toward the LMC has allowed powerful statements to be made about the dark population in the halo of our Galaxy, indicating that the MACHO halo fraction could be as high as f=0.5 with a most probable MACHO mass being ~ 0.5Msun. However, to date the LMC has been the only line of sight out of our Galaxy's halo. Clearly, another line of sight would provide a consistency check on these results, as well as another contraint on models of the halo, in particular on halo flattening. The SMC affords us this second line of sight. Here we give a status report on our upcoming 4 year results toward the SMC. We present the results of a preliminary analysis on over 2.2 million stars from 3 square degrees and discuss the implications for the dark matter in the halo of our Galaxy. A detailed analysis of the microlensing candidates toward the SMC, with blending and parallax fits, will be shown. This work is dedicated to the memory of Alex Rodgers.
Persian competing word test: Development and preliminary results in normal children
Directory of Open Access Journals (Sweden)
Mohammad Ebrahim Mahdavi
2008-12-01
Full Text Available Background and Aim: Assessment of central auditory processing skills needs various behavioral tests in format of a test battery. There is a few Persian speech tests for documenting central auditory processing disorders. The purpose of this study was developing a dichotic test formed of one-syllabic words suitable for evaluation of central auditory processing in Persian language children and reporting its preliminary results in a group of normal children.Materials and Methods: Persian words in competing manner test was developed utilizing most frequent monosyllabic words in children storybooks reported in the previous researches. The test was performed at MCL on forty-five normal children (39 right-handed and 6 left-handed aged 5-11 years. The children did not show any obvious problem in hearing, speech, language and learning. Free (n=28 and directed listening (n=17 tasks were investigated.Results: The results show that in directed listening task, there is significant advantage for performance of pre-cued ear relative to opposite side. Right ear advantage is evident in free recall condition. Average performance of the children in directed recall is significantly better than free recall. Average row score of the test increases with the children age.Conclusion: Persian words in competing manner test as a dichotic test, can show major characteristics of dichotic listening and effect of maturation of central auditory system on it in normal children.
Pharmacokinetics of 125-I-labelled meta-iodo-benzyl-guanidine : Preliminary results
International Nuclear Information System (INIS)
Mansouri, A.; Benhidour, A. , Algiers; Algeria)
1993-01-01
The study of some pharmacokinetics providing the mechanism of uptake amd metabolism parameters for the 125-I-mIBG is described. NMRI mice are used for plasma binding study, the animals are killed by decapitation after intravenously (IV) injection of 125-I-mIBG. Wistar rats are used in urinary excretion study. After IV injection, animals are placed in metabolic cages to collect urine. For biodistribution, the rats are killed at different time intervals. The considered organs are removed. The radioactivity of all parameters was performed by gamma counter. The results show that the blood clearance is very high after several hours post injection and very high after 72 hours. Furthermore, we note a rapid excretion of radioactivity 24 hours post injection. However, we observe that 72 hours after injection, the radioactivity per gram of different organs was normalized according to the adrenal glands. Also, we note, that the adrenal glands may be the only target organs 48 hours post injection. These results confirm that 125-I-mIBG a high affinity for the adrenergic innervation organs (Adrenal glands, salivary glands, heart and spleen)
Preliminary clinical results of locoregional hyperthermia for primary and secondary bone tumors
Energy Technology Data Exchange (ETDEWEB)
Zhu, J.L.; Nagata, Yasushi; Kanamori, Shuichi; Mitsumori, Michihide; Okuno, Yoshishige; Horii, Naotoshi; Nishimura, Yasumasa; Masunaga, Shinitiro; Hiraoka, Masahiro [Kyoto Univ. (Japan). Graduate School of Medicine
2000-03-01
Nineteen primary and secondary bone tumors in 16 patients were treated with hyperthermia plus radiotherapy and/or chemotherapy between 1982 and 1997 at Kyoto University Hospital. The thermometric and clinical results were analyzed retrospectively. In 55 of 86 hyperthermia sessions, the intratumor temperature was measured using a thermometer. Of the 19 tumors, 16 (84%) received heat treatment 4-7 times, and 3 (16%) received 1 or 2 treatments of hyperthermia. The mean maximum, mean minimum and average intratumor temperatures were 42.9, 40.4 and 41.6 deg C, respectively, and 12 (67%) reached a tumor maximum temperature above 42.5 deg C. The durations that intratumor points exceeded 42, 41 and 40 deg C were 27, 34 and 38 min, respectively. The local tumor response to treatment was assessed using X-ray computed tomography. The local response rate was 16% and the local pain relief rate was 63%. The 1-year cumulative survival rate was 60%. Our preliminary results indicated that thermoradiotherapy and thermochemotherapy are clinicaly feasible and potentially beneficial in the management of locally advanced bone tumors. (author)
Seton, M.; Williams, S.; Mortimer, N. N.; Meffre, S.; Moore, J.; Micklethwaite, S.; Zahirovic, S.
2013-12-01
The eastern Coral Sea region is an underexplored area at the northeastern corner of the Australian plate, where long-lived interaction between the Pacific and Australian plate boundaries has resulted in an intricate assemblage of deep oceanic basins and ridges, continental fragments and volcanic products. A paucity of marine geophysical and geological data from this complex region has resulted in the lack of a clear conceptual framework to describe its formation, ultimately affecting our understanding of the connection between the plate boundaries of the SW Pacific and SE Asia. In particular, the tectonic relationship between two back-arc basins, the Santa Cruz and d'Entrecasteaux Basins, and the South Rennell Trough, has yet to be resolved. In October-November, 2012, we collected 6,200 km of marine magnetic, 6,800 km of gravity and over 13,600 km2 of swath bathymetry data from the eastern Coral Sea onboard the RV Southern Surveyor. A complementary dredging program yielded useful samples from 14 seafloor sites. Our preliminary geochemical interpretation of the dredge samples obtained from the South Rennell Trough reveal volcanic rocks resembling MORB or BABB-type basalts, similar in composition to the recently re-analysed and dated ORSTOM dredges from the area that yielded ~28 Ma MORB-like basalts. Swath bathymetry profiles from the Santa Cruz Basin reveal that the South Rennell Trough extends into this basin, with seafloor spreading fabric being parallel to the trough. Preliminary analysis of the three full and four partial new magnetic anomaly profiles across the Santa Cruz Basin, coupled with limited existing profiles, reveals that the basin may have formed between Chrons 13-18 (~32-38 Ma), with an extinct spreading ridge along the inferred continuation of the South Rennell Trough, consistent with ORSTOM age dates. Our results suggest that the South Rennell Trough is an extinct southwestward propagating spreading ridge, which may have initiated along a pre
Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
Directory of Open Access Journals (Sweden)
Jennifer A Watson
2015-06-01
Full Text Available Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn is a single nucleotide substitution in hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs, a component of the endosomal sorting complex required for transport (ESCRT. The tn mice exhibit hypokenesis, muscle weakness, reduced muscle size and early perinatal lethality by 5-weeks of age. Although HGS has been suggested to be essential for the sorting of ubiquitinated membrane proteins to the lysosome, there were no alterations in receptor tyrosine kinase levels in the central nervous system, and only a modest decrease in tropomyosin receptor kinase B (TrkB in the sciatic nerves of the tn mice. Instead, loss of HGS resulted in structural alterations at the neuromuscular junction (NMJ, including swellings and ultra-terminal sprouting at motor axon terminals and an increase in the number of endosomes and multivesicular bodies. These structural changes were accompanied by a reduction in spontaneous and evoked release of acetylcholine, indicating a deficit in neurotransmitter release at the NMJ. These deficits in synaptic transmission were associated with elevated levels of ubiquitinated proteins in the synaptosome fraction. In addition to the deficits in neuronal function, mutation of Hgs resulted in both hypermyelinated and dysmyelinated axons in the tn mice, which supports a growing body of evidence that ESCRTs are required for proper myelination of peripheral nerves. Our results indicate that HGS has multiple roles in the nervous system and demonstrate a previously unanticipated requirement for ESCRTs in the maintenance of synaptic transmission.
A Morphing Technique Applied to Lung Motions in Radiotherapy: Preliminary Results
Directory of Open Access Journals (Sweden)
R. Laurent
2010-01-01
Full Text Available Organ motion leads to dosimetric uncertainties during a patient’s treatment. Much work has been done to quantify the dosimetric effects of lung movement during radiation treatment. There is a particular need for a good description and prediction of organ motion. To describe lung motion more precisely, we have examined the possibility of using a computer technique: a morphing algorithm. Morphing is an iterative method which consists of blending one image into another image. To evaluate the use of morphing, Four Dimensions Computed Tomography (4DCT acquisition of a patient was performed. The lungs were automatically segmented for different phases, and morphing was performed using the end-inspiration and the end-expiration phase scans only. Intermediate morphing files were compared with 4DCT intermediate images. The results showed good agreement between morphing images and 4DCT images: fewer than 2 % of the 512 by 256 voxels were wrongly classified as belonging/not belonging to a lung section. This paper presents preliminary results, and our morphing algorithm needs improvement. We can infer that morphing offers considerable advantages in terms of radiation protection of the patient during the diagnosis phase, handling of artifacts, definition of organ contours and description of organ motion.
Tan, Kok-Yang; Seow-Choen, Francis; Hai, Chew Heng; Thye, Gan Kok
2009-03-01
Anal fissures can cause morbidity in an otherwise healthy young patient. The process of evacuation results in stretching and descent of the anoderm and perineum especially posteriorly. Posterior perineal support may provide counter pressure at the posterior aspect of the pelvic floor, balancing the pressure exerted by the faeces on the anal wall, thus improving evacuation and reducing the trauma associated with it, and reducing symptoms of anal fissures. Symptoms of constipation may also be reduced secondarily. We report the preliminary results with a novel, simple and noninvasive method of treatment provided by a toilet seat device. A prospective study was performed in 32 patients. The study was designed mainly to investigate the patients' subjective perceptions of their symptoms related to anal fissures and constipation. Questionnaires were provided to patients before, during and after treatment. The study revealed statistically significant improvement in pain, bleeding, symptoms of constipation and abdominal discomfort after 3 months usage of the device. The odds of patients perceiving an improvement in symptoms were also significantly increased after 3 months of treatment compared to 2 weeks of treatment. This preliminary study revealed that a posterior perineal support device can bring about significant improvement in the symptoms of patients with anal fissures. There may also be secondary benefits of a reduction in the symptoms of constipation. Although not conclusive, these results should serve as a springboard for further research into this area.
2011-10-11
... DEPARTMENT OF COMMERCE International Trade Administration [A-533-810] Stainless Steel Bar From India: Extension of Time Limit for the Preliminary Results of the 2010-2011 Antidumping Duty... review of the antidumping duty order on stainless steel bar from India, covering the period February 1...
Directory of Open Access Journals (Sweden)
Tarcila Fontes de Lima Gomes Lucena
2018-01-01
Conclusion: The present study demonstrated subclinical myocardial dysfunction using TDI in asymptomatic PAPS patients. TDI is non-invasive and cost effective. Prospective studies including a large number of participants in order to confirm these preliminary data are needed.
Polarimetry at 1.3 mm using MILLIPOL - methods and preliminary results for Orion
International Nuclear Information System (INIS)
Barvainis, R.; Clemens, D.P.; Leach, R.
1988-01-01
This paper describes a polarimeter for use at wavelengths near 1 mm, designed to be self-contained and portable. Only minor modifications should be required to adapt this instrument for use on any of several millimeter and submillimeter telescopes. The polarimeter system and data-taking techniques are described, and a preliminary measurement is reported of the polarized dust emission from the Orion KL region at 1.3 mm using the NRAO 12 m telescope. The results are similar to previous polarization measurements of Orion at far-infrared and submillimeter wavelengths. The magnetic field direction implied by the polarization position angle is parallel to that found in the surrounding Orion region using optical and near- to midinfrared polarimetric techniques. 17 references
Iwaniec, U T; Philbrick, K A; Wong, C P; Gordon, J L; Kahler-Quesada, A M; Olson, D A; Branscum, A J; Sargent, J L; DeMambro, V E; Rosen, C J; Turner, R T
2016-10-01
Room temperature housing (22 °C) results in premature cancellous bone loss in female mice. The bone loss was prevented by housing mice at thermoneutral temperature (32 °C). Thermogenesis differs markedly between mice and humans and mild cold stress induced by standard room temperature housing may introduce an unrecognized confounding variable into preclinical studies. Female mice are often used as preclinical models for osteoporosis but, in contrast to humans, mice exhibit cancellous bone loss during growth. Mice are routinely housed at room temperature (18-23 °C), a strategy that exaggerates physiological differences in thermoregulation between mice (obligatory daily heterotherms) and humans (homeotherms). The purpose of this investigation was to assess whether housing female mice at thermoneutral (temperature range where the basal rate of energy production is at equilibrium with heat loss) alters bone growth, turnover and microarchitecture. Growing (4-week-old) female C57BL/6J and C3H/HeJ mice were housed at either 22 or 32 °C for up to 18 weeks. C57BL/6J mice housed at 22 °C experienced a 62 % cancellous bone loss from the distal femur metaphysis during the interval from 8 to 18 weeks of age and lesser bone loss from the distal femur epiphysis, whereas cancellous and cortical bone mass in 32 °C-housed mice were unchanged or increased. The impact of thermoneutral housing on cancellous bone was not limited to C57BL/6J mice as C3H/HeJ mice exhibited a similar skeletal response. The beneficial effects of thermoneutral housing on cancellous bone were associated with decreased Ucp1 gene expression in brown adipose tissue, increased bone marrow adiposity, higher rates of bone formation, higher expression levels of osteogenic genes and locally decreased bone resorption. Housing female mice at 22 °C resulted in premature cancellous bone loss. Failure to account for species differences in thermoregulation may seriously confound interpretation of studies
Preliminary PCA/TT Results on MRO CRISM Multispectral Images
Klassen, David R.; Smith, M. D.
2010-10-01
Mars Reconnaissance Orbiter arrived at Mars in March 2006 and by September had achieved its science-phase orbit with the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) beginning its visible to near-infrared (VIS/NIR) spectral imaging shortly thereafter. One goal of CRISM is to fill in the spatial gaps between the various targeted observations, eventually mapping the entire surface. Due to the large volume of data this would create, the instrument works in a reduced spectral sampling mode creating "multispectral” images. From these data we can create image cubes using 64 wavelengths from 0.410 to 3.923 µm. We present here our analysis of these multispectral mode data products using Principal Components Analysis (PCA) and Target Transformation (TT) [1]. Previous work with ground-based images [2-5] has shown that over an entire visible hemisphere, there are only three to four meaningful components using 32-105 wavelengths over 1.5-4.1 µm the first two are consistent over all temporal scales. The TT retrieved spectral endmembers show nearly the same level of consistency [5]. The preliminary work on the CRISM images cubes implies similar results; three to four significant principal components that are fairly consistent over time. These components are then used in TT to find spectral endmembers which can be used to characterize the surface reflectance for future use in radiative transfer cloud optical depth retrievals. We present here the PCA/TT results comparing the principal components and recovered endmembers from six reconstructed CRISM multi-spectral image cubes. References: [1] Bandfield, J. L., et al. (2000) JGR, 105, 9573. [2] Klassen, D. R. and Bell III, J. F. (2001) BAAS 33, 1069. [3] Klassen, D. R. and Bell III, J. F. (2003) BAAS, 35, 936. [4] Klassen, D. R., Wark, T. J., Cugliotta, C. G. (2005) BAAS, 37, 693. [5] Klassen, D. R. (2009) Icarus, 204, 32.
International Nuclear Information System (INIS)
Sarmento, S.; Wolterbeek, H.Th.; Verburg, T.G.; Freitas, M.C.
2008-01-01
This study, framed within geographical epidemiology, presents preliminary findings concerning the association between the concentrations of chemical elements obtained through atmospheric biomonitoring with lichens and cancer mortality in the Portuguese population. Exploratory analyses were performed to identify potential confounders for the relationships between chemical elements and neoplasm mortality and to assess the extent of their interference. The results of this study highlight some methodological and conceptual difficulties inherent to observational and geographical studies, in the specific context of the Portuguese population, and the challenge posed by the large numbers of pollutants considered. - Relationship between chemical elements and mortality from neoplasms in the Portuguese population and the effect of confounders
International Nuclear Information System (INIS)
Alves de Freitas, Antonio; Abrao, Alcidio; Godoy dos Santos, Adir Janete; Pecequilo, Brigitte Roxana Soreanu
2008-01-01
An analytical procedure was established in order to obtain selective fractions containing radium isotopes ( 228 Ra), thorium ( 232 Th), and rare earths from RETOTER (REsiduo de TOrio e TErras Raras), a solid residue rich in rare earth elements, thorium isotopes and small amount of natural uranium generated from the operation of a thorium pilot plant for purification and production of pure thorium nitrate at IPEN -CNEN/SP. The paper presents preliminary results of 228 Ra, 226 Ra, 238 U, 210 Pb, and 40 K concentrations in the selective fractions and total residue determined by high-resolution gamma spectroscopy, considering radioactive equilibrium of the samples
Biasotto, M; Ricceri, R; Scuor, N; Schmid, C; Sandrucci, M A; Di Lenarda, R; Matteazzi, P
2003-01-01
This study concerns a novel powder metallurgy method for producing porous titanium (pTi) exhibiting high mechanical properties. The preparation procedure consisted of the following stages: first, the preparation of Ti and titanium hydride (TiH2) powder mixtures and their consolidation with a cold isostatic press, followed by a sintering of the green bodies performed with hot isostatic press (HIP) equipment. Thermal decomposition in controlled environment of the TiH2 phase results in the foam structure. The resulting porosity percolates with a volume fraction of approximately 20%. The final material exhibits interesting mechanical properties, comparable to those of full density titanium (between grade 2 and grade 3), with the advantage of a minor density. The samples produced were tested to verify their biological response by studying the effectiveness of osteoblast adhesion and growth. In this preliminary study, osteoblastic cell morphology was investigated and compared to that observed on fully dense commercially pure titanium (Ti-cp) (ASTM, grade 3). The preliminary results were promising regarding cellular adhesion and spreading. (Journal of Applied Biomaterials & Biomechanics 2003; 1: 172-7).
Extremity exposure in nuclear medicine: Preliminary results of a European study
International Nuclear Information System (INIS)
Merce, M. S.; Ruiz, N.; Barth, I.; Carnicer, A.; Donadille, L.; Ferrari, P.; Fulop, M.; Ginjaume, M.; Gualdrini, G.; Krim, S.; Mariotti, F.; Ortega, X.; Rimpler, A.; Vanhavere, F.; Baechler, S.
2011-01-01
The Work Package 4 of the ORAMED project, a collaborative project (2008-11) supported by the European Commission within its seventh Framework Programme, is concerned with the optimisation of the extremity dosimetry of medical staff in nuclear medicine. To evaluate the extremity doses and dose distributions across the hands of medical staff working in nuclear medicine departments, an extensive measurement programme has been started in 32 nuclear medicine departments in Europe. This was done using a standard protocol recording all relevant information for radiation exposure, i.e. radiation protection devices and tools. This study shows the preliminary results obtained for this measurement campaign. For diagnostic purposes, the two most-used radionuclides were considered: 99m Tc) and 18 F. For therapeutic treatments, Zevalin R and DOTATOC (both labelled with 90 Y) were chosen. Large variations of doses were observed across the hands depending on different parameters. Furthermore, this study highlights the importance of the positioning of the extremity dosemeter for a correct estimate of the maximum skin doses. (authors)
International Nuclear Information System (INIS)
Cordova Junior, Ardo Lotar; Salvajoli, Joao Victor; Pelizzon, Antonio CAssio Assis; Cecilio, Paulo Jose
1998-01-01
Describe the technique and preliminary results of high dose rate brachytherapy (HDRB) in localized prostate cancer. Subjects methods: Between March, 1997 and April, 1998, 26 patients were treated with external beam radiotherapy (45 to 50.4 Gy - 1.8 Gy per day) and implants (16 Gy in 2 days - twice a day). Median age was 68 years. The distribution by clinical stage was: 5 T1c, 9 T2a, 10 T2b and 2 T3a. Median initial PSA was 16 ng/ml. Results: With a median follow-up of 4 months, 85% of patients showed normal levels of PSA, with a median of 0.6 ng/ml, 60 to 90 days after treatment. Dysuria grades 1 and 2 and proctitis grade 1 were found in 11,3 and 5 patients, respectively. Conclusion: The method is safe, with acceptable early side effects. Longer follow-up is necessary before drawing any conclusions. (author)
International Nuclear Information System (INIS)
White, Maurice A.; Qiu Songgang; Augenblick, Jack E.
2000-01-01
Free-piston Stirling engines offer a relatively mature, proven, long-life technology that is well-suited for advanced, high-efficiency radioisotope space power systems. Contracts from DOE and NASA are being conducted by Stirling Technology Company (STC) for the purpose of demonstrating the Stirling technology in a configuration and power level that is representative of an eventual space power system. The long-term objective is to develop a power system with an efficiency exceeding 20% that can function with a high degree of reliability for up to 15 years on deep space missions. The current technology demonstration convertors (TDC's) are completing shakedown testing and have recently demonstrated performance levels that are virtually identical to projections made during the preliminary design phase. This paper describes preliminary test results for power output, efficiency, and vibration levels. These early results demonstrate the ability of the free-piston Stirling technology to exceed objectives by approximately quadrupling the efficiency of conventional radioisotope thermoelectric generators (RTG's)
White, Maurice A.; Qiu, Songgang; Augenblick, Jack E.
2000-01-01
Free-piston Stirling engines offer a relatively mature, proven, long-life technology that is well-suited for advanced, high-efficiency radioisotope space power systems. Contracts from DOE and NASA are being conducted by Stirling Technology Company (STC) for the purpose of demonstrating the Stirling technology in a configuration and power level that is representative of an eventual space power system. The long-term objective is to develop a power system with an efficiency exceeding 20% that can function with a high degree of reliability for up to 15 years on deep space missions. The current technology demonstration convertors (TDC's) are completing shakedown testing and have recently demonstrated performance levels that are virtually identical to projections made during the preliminary design phase. This paper describes preliminary test results for power output, efficiency, and vibration levels. These early results demonstrate the ability of the free-piston Stirling technology to exceed objectives by approximately quadrupling the efficiency of conventional radioisotope thermoelectric generators (RTG's). .
Improved self-exclusion program: preliminary results.
Tremblay, Nicole; Boutin, Claude; Ladouceur, Robert
2008-12-01
The gambling industry has offered self-exclusion programs for quite a long time. Such measures are designed to limit access to gaming opportunities and provide problem gamblers with the help they need to cease or limit their gambling behaviour. However, few studies have empirically evaluated these programs. This study has three objectives: (1) to observe the participation in an improved self-exclusion program that includes an initial voluntary evaluation, phone support, and a mandatory meeting, (2) to evaluate satisfaction and usefulness of this service as perceived by self-excluders, (3) to measure the preliminary impact of this improved program. One hundred sixteen self-excluders completed a questionnaire about their satisfaction and their perception of the usefulness during the mandatory meeting. Among those participants, 39 attended an initial meeting. Comparisons between data collected at the initial meeting and data taken at the final meeting were made for those 39 participants. Data showed that gamblers chose the improved self-exclusion program 75% of the time; 25% preferred to sign a regular self-exclusion contract. Among those who chose the improved service, 40% wanted an initial voluntary evaluation and 37% of these individuals actually attended that meeting. Seventy percent of gamblers came to the mandatory meeting, which was a required condition to end their self-exclusion. The majority of participants were satisfied with the improved self-exclusion service and perceived it as useful. Major improvements were observed between the final and the initial evaluation on time and money spent, consequences of gambling, DSM-IV score, and psychological distress. The applicability of an improved self-exclusion program is discussed and, as shown in our study, the inclusion of a final mandatory meeting might not be so repulsive for self-excluders. Future research directives are also proposed.
Energy Technology Data Exchange (ETDEWEB)
Proia, R.L.; Yamanaka, S.; Johnson, M.D. [and others
1994-09-01
Tay-Sachs disease, the prototype of the G{sub M2} gangliosidoses, is a catastrophic neurodegenerative disorder of infancy. The disease is caused by mutations in the HEXA gene resulting in an absence of the lysosomal enzyme, {beta}-hexosaminidase A. As consequence of the enzyme deficiency, G{sub M2} ganglioside accumulates progressively, beginning early in fetal life, to excessive amounts in the central nervous system (CNS). Rapid mental and motor deterioration starting in the first year of life leads to death by 2 to 4 years of age. Through the targeted disruption of the Hexa gene in embryonic stem cells, we have produced mice with biochemical and neuropathologic features of Tay-Sachs disease. The mutant mice exhibited less than 1% of normal {beta}-hexosaminidase A activity and accumulated G{sub M2} ganglioside in their CNS in an age-dependent manner. The accumulated ganglioside was stored in neurons as membranous cytoplasmic bodies characteristically found in the neurons of Tay-Sachs disease patients. At three to five months of age the mutant mice showed no apparent defects in motor or memory function. These {beta}-hexosaminidase A deficient mice should be useful for devising strategies to introduce functional enzymes and genes into the CNS. This model may also be valuable for studying the biochemical and pathologic changes occurring during the course of the disease.
Digital Repository Service at National Institute of Oceanography (India)
Sarkar, A.; Rajkumar, R.; Gairola, R.M.; Gohil, B.S.; Vethamony, P.; Rao, L.V.G.
the respective correlation coefficients. Preliminary results with limited processed data showed that the correlation coefficients are approximately 0.6. Sample maps of wave and wind (satellite derived) in 2.5 degrees x 2.5 degrees grids have been prepared...
Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation.
Kim, Eun; Erdos, Geza; Huang, Shaohua; Kenniston, Thomas; Falo, Louis D; Gambotto, Andrea
2016-11-01
Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA). The immunogenicity of these two vaccines, named Ad5.ZIKV-Efl and ZIKV-rEfl, was tested in C57BL/6 mice. Prime/boost immunization regimen was associated with induction of a ZIKV-specific antibody response, which provided neutralizing immunity. Moreover, protection was evaluated in seven-day-old pups after virulent ZIKV intraperitoneal challenge. Pups born to mice immunized with Ad5.ZIKV-Efl were all protected against lethal challenge infection without weight loss or neurological signs, while pups born to dams immunized with MNA-ZIKV-rEfl were partially protected (50%). No protection was seen in pups born to phosphate buffered saline-immunized mice. This study illustrates the preliminary efficacy of the E ZIKV antigen vaccination in controlling ZIKV infectivity, providing a promising candidate vaccine and antigen format for the prevention of Zika virus disease. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
International Nuclear Information System (INIS)
Sacks, I.J.; Ashmore, B.C.; Champney, J.M.; Alesso, H.P.
1983-06-01
This report provides preliminary results generated by a Digraph Matrix Analysis (DMA) for a Systems Interaction analysis performed on the Safety Injection System of the Tennessee Valley Authority Watts Bar Nuclear Power Plant. An overview of DMA is provided along with a brief description of the computer codes used in DMA
Preliminary results from Brookhaven Experiment 802 with 14.5 GeVu 28Si
International Nuclear Information System (INIS)
1987-01-01
Preliminary data on beam calorimetry, charged particle multiplicities, pseudo-rapidity distributions and hadron spectroscopy from 28 Si + Al and Au at 14.5 GeV per nucleon are presented. Comments on nuclear stopping, multiplicity systematics, and Kπ ratios are offered. 5 refs., 6 figs., 1 tab
Directory of Open Access Journals (Sweden)
Harold G. Koenig
2012-01-01
Full Text Available This paper (1 reviews the physical and religious barriers to CBT that disabled medically ill-depressed patients face, (2 discusses research on the relationship between religion and depression-induced physiological changes, (3 describes an ongoing randomized clinical trial of religious versus secular CBT in chronically ill patients with mild-to-moderate major depression designed to (a overcome physical and religious barriers to CBT and (b compare the efficacy of religious versus secular CBT in relieving depression and improving immune and endocrine functions, and (4 presents preliminary results that illustrate the technical difficulties that have been encountered in implementing this trial. CBT is being delivered remotely via instant messaging, telephone, or Skype, and Christian, Jewish, Muslim, Buddhist, and Hindu versions of religious CBT are being developed. The preliminary results described here are particular to the technologies employed in this study and are not results from the CBT clinical trial whose findings will be published in the future after the study ends and data are analyzed. The ultimate goal is to determine if a psychotherapy delivered remotely that integrates patients’ religious resources improves depression more quickly than a therapy that ignores them, and whether religious CBT is more effective than conventional CBT in reversing depression-induced physiological changes.
Biological image construction by using Raman radiation and Pca: preliminary results
International Nuclear Information System (INIS)
Martinez E, J. C.; Cordova F, T.; Hugo R, V.
2015-10-01
Full text: In the last years, the Raman spectroscopy (Rs) technique has had some applications in the study and analysis of biological samples, due to it is able to detect concentrations or presence of certain organic and inorganic compounds of medical interest. In this work, raw data were obtained through measurements in selected points on a square regions in order to detect specific organic / inorganic compounds on biological samples. Gold nano stars samples were prepared and coated with membrane markers (CD 10+ and CD 19+) and diluted in leukemic B lymphocytes. Each data block was evaluated independently by the method of principal component analysis (Pca) in order to find representative dimensionless values (Cp) for each Raman spectrum in a specific coordinate. Each Cp was normalized in a range of 0-255 in order to generate a representative image of 8 bits of the region under study. Data acquisition was performed with Raman microscopy system Renishaw in Via in the range of 550 to 1700 cm-1 with a 785 nm laser source, with a power of 17 m W and 15 s of exposure time were used for each spectrum. In preliminary results could detect the presence of molecular markers CD 10+ and CD 19+ with gold nano stars and discrimination between both markers. The results suggest conducting studies with specific concentrations organic and inorganic materials. (Author)
Biological image construction by using Raman radiation and Pca: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Martinez E, J. C. [IPN, Unidad Profesional Interdisciplinaria de Ingenieria, Campus Guanajuato, Av. Mineral de Valenciana 200, Col. Fracc. Industrial Puerto Interior, 36275 Silao, Guanajuato (Mexico); Cordova F, T. [Universidad de Guanajuato, DIC, Departamento de Ingenieria Fisica, Loma del Bosque No. 103, Col. Lomas del Campestre, 37150 Leon, Guanajuato (Mexico); Hugo R, V., E-mail: jcmartineze@ipn.mx [Universidad de Guadalajara, Centro Universitario de Tonala, Morelos No. 180, 69584 Tonala, Jalisco (Mexico)
2015-10-15
Full text: In the last years, the Raman spectroscopy (Rs) technique has had some applications in the study and analysis of biological samples, due to it is able to detect concentrations or presence of certain organic and inorganic compounds of medical interest. In this work, raw data were obtained through measurements in selected points on a square regions in order to detect specific organic / inorganic compounds on biological samples. Gold nano stars samples were prepared and coated with membrane markers (CD 10+ and CD 19+) and diluted in leukemic B lymphocytes. Each data block was evaluated independently by the method of principal component analysis (Pca) in order to find representative dimensionless values (Cp) for each Raman spectrum in a specific coordinate. Each Cp was normalized in a range of 0-255 in order to generate a representative image of 8 bits of the region under study. Data acquisition was performed with Raman microscopy system Renishaw in Via in the range of 550 to 1700 cm-1 with a 785 nm laser source, with a power of 17 m W and 15 s of exposure time were used for each spectrum. In preliminary results could detect the presence of molecular markers CD 10+ and CD 19+ with gold nano stars and discrimination between both markers. The results suggest conducting studies with specific concentrations organic and inorganic materials. (Author)
{sup 166} Ho-EDTMP in detecting bone metastases: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Achando, S.S.; Fernandes, L.; Herrerias, R.; Muramoto, E.; Almeida, M.A.T.; Pereira, N.S. de; Mengatti, J. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)
1995-12-31
Holmium-166-EDTMP (ethylene-dimine-tetra methylene phosphonic acid) due to its promising biological properties, has proved to be a palliating therapeutic agent for bone cancer in human beings. In a basic medium, {sup 166} Ho-EDTMP can be readily prepared with a complexing molar ratio EDTMP/Ho 4.34. The radiochemical purity of the complex was higher than 98%. The biodistribution in rats and mice, showed a high skeletal uptake, a fast blood clearance and a low soft tissue uptake and a lesion to normal bone ratio equal to 2. (author). 3 refs., 4 tabs.
Directory of Open Access Journals (Sweden)
Ozburn Angela R
2012-10-01
Full Text Available Abstract Background The inability to reduce or regulate alcohol intake is a hallmark symptom for alcohol use disorders. Research on novel behavioral and genetic models of experience-induced changes in drinking will further our knowledge on alcohol use disorders. Distinct alcohol self-administration behaviors were previously observed when comparing two F1 hybrid strains of mice: C57BL/6J x NZB/B1NJ (BxN show reduced alcohol preference after experience with high concentrations of alcohol and periods of abstinence while C57BL/6J x FVB/NJ (BxF show sustained alcohol preference. These phenotypes are interesting because these hybrids demonstrate the occurrence of genetic additivity (BxN and overdominance (BxF in ethanol intake in an experience dependent manner. Specifically, BxF exhibit sustained alcohol preference and BxN exhibit reduced alcohol preference after experience with high ethanol concentrations; however, experience with low ethanol concentrations produce sustained alcohol preference for both hybrids. In the present study, we tested the hypothesis that these phenotypes are represented by differential production of the inducible transcription factor, ΔFosB, in reward, aversion, and stress related brain regions. Results Changes in neuronal plasticity (as measured by ΔFosB levels were experience dependent, as well as brain region and genotype specific, further supporting that neuronal circuitry underlies motivational aspects of ethanol consumption. BxN mice exhibiting reduced alcohol preference had lower ΔFosB levels in the Edinger-Westphal nucleus than mice exhibiting sustained alcohol preference, and increased ΔFosB levels in central medial amygdala as compared with control mice. BxN mice showing sustained alcohol preference exhibited higher ΔFosB levels in the ventral tegmental area, Edinger-Westphal nucleus, and amygdala (central and lateral divisions. Moreover, in BxN mice ΔFosB levels in the Edinger-Westphal nucleus and ventral
Grover, Davinder S; Godfrey, David G; Smith, Oluwatosin; Feuer, William J; Montes de Oca, Ildamaris; Fellman, Ronald L
2014-04-01
To introduce a minimally invasive, ab interno approach to a circumferential 360-degree trabeculotomy and to report the preliminary results. Retrospective, noncomparative cases series. Eighty-five eyes of 85 consecutive patients who sought treatment at Glaucoma Associates of Texas with uncontrolled open-angle glaucoma and underwent gonioscopy-assisted transluminal trabeculotomy (GATT) for whom there was at least 6 months of follow-up data. Retrospective chart review of patients who underwent GATT by 4 of the authors (D.S.G., D.G.G., O.S., R.L.F.) between October 2011 and October 2012. The surgery was performed in adults with various open-angle glaucomas. Intraocular pressure (IOP), glaucoma medications, visual acuity, and intraoperative as well as postoperative complications. Eighty-five patients with an age range of 24 to 88 years underwent GATT with at least 6 months of follow-up. In 57 patients with primary open-angle glaucoma, the IOP decreased by 7.7 mmHg (standard deviation [SD], 6.2 mm Hg; 30.0% [SD, 22.7%]) with an average decrease in glaucoma medications of 0.9 (SD, 1.3) at 6 months. In this group, the IOP decreased by 11.1 mmHg (SD, 6.1 mmHg; 39.8% [SD, 16.0%]) with 1.1 fewer glaucoma medications at 12 months. In the secondary glaucoma group of 28 patients, IOP decreased by 17.2 mmHg (SD, 10.8 mmHg; 52.7% [SD, 15.8%]) with an average of 2.2 fewer glaucoma medications at 6 months. In this group, the IOP decreased by 19.9 mmHg (SD, 10.2 mmHg; 56.8% [SD, 17.4%]) with an average of 1.9 fewer medications (SD, 2.1) at 12 months. Treatment was considered to have failed in 9% (8/85) of patients because of the need for further glaucoma surgery. The cumulative proportion of failure at 1 year ranged from 0.1 to 0.32, depending on the group. Lens status or concurrent cataract surgery did not have a statistically significant effect on IOP in eyes that underwent GATT at either 6 or 12 months (P > 0.35). The most common complication was transient hyphema, seen in
International Nuclear Information System (INIS)
Gnirk, P.F.; Grams, W.H.; Zeller, T.J.; Ellis, D.B.; Pariseau, W.G.; Fossum, A.F.; Ratigan, J.L.; Hansen, F.D.
1975-01-01
Results of preliminary analysis of the stability of mines in salt formations underlying Eddy and Lea Counties in New Mexico are presented. Methods and equipment for drilling canister emplacement holes in these formations were evaluated along with methods for excavating storage areas and transport of the excavated salt. Progress during the period is reported in chapters on geological and rock properties at the repository site, preliminary mine layout, basic requirements for repository usage, excavation geometries, drill selection, excavation systems, and safety requirements
Directory of Open Access Journals (Sweden)
M. Di Stefano
2013-01-01
Full Text Available The aim of this preliminary research is to investigate the reliability of a new qualitative parameter, called Trabecular Bone Score (TBS, recently proposed for evaluating the microarchitectural arrangement of cancellous bone in scans carried out by dual energy X-ray absorptiometry (DXA. Vertebral bodies of 15 fresh samples of lumbar spines of adult pig were analysed either in basal conditions and with altered microarchitecture of the cancellous bone obtained by progressive drilling. The examined bony areas do not show changes in bone mineral density (BMD, whereas TBS values decrease with the increasing alteration of the vertebral microtrabecular structure. Our preliminary data seem to confirm the reliability of TBS as a qualitative parameter useful for evaluating the microarchitectural strength in bony areas quantitatively analysed by DXA.
International Nuclear Information System (INIS)
Moroz, B.B.; Deshevoj, Yu.B.; Lebedev, V.G.; Lyrshchikova, A.V.; Vorotnikova, T.V.
1997-01-01
In experiments on rats and mice it was shown that the preliminary protected gamma-irradiation with cumulative dose of 0.9 Gy (dose rate - 0.03 Gy/day) or single short-term gamma-irradiation with dose of 0.9 Gy (dose rate - 1.61 Gy/min) inhibited development of adaptive reactions and compensatory abilities of the hematopoietic system under long-term emotional stress
A novel ultra-short scanning nuclear microprobe: Design and preliminary results
International Nuclear Information System (INIS)
Lebed, S.; Butz, T.; Vogt, J.; Reinert, T.; Spemann, D.; Heitmann, J.; Stachura, Z.; Lekki, J.; Potempa, A.; Styczen, J.; Sulkio-Cleff, B.
2001-01-01
The paper describes an optimized scanning nuclear microprobe (MP) with a new ultra-short (total length of 1.85 m) probe forming system based on a divided Russian quadruplet (DRQ) of magnetic quadrupole lenses. Modern electrostatic accelerators have a comparatively high beam brightness of about 10-25 pA/μm 2 /mrad 2 /MeV. This allows the MP proposed to provide a high lateral resolution even with large (1%) parasitic (sextupole and octupole) pole tip field components in all lenses. The features of the design permit the MP operation in the high current and low current modes with a short working distance and inexpensive quadrupole lenses. A new quadrupole doublet design has been developed for the MP. In the present work the calculated features of the new MP are compared with preliminary experimental results obtained with a similar system (total length of 2.3 m) at the INP in Cracow. The new MP is promising for studies of solids or biological samples with high resolutions (0.08-2 μm) in both modes under ambient conditions. A vertical version of the ultra-short MP can be very useful for single ion bombardments of living cells
Preliminary results of the International Fusion Materials Irradiation Facility deuteron injector
Energy Technology Data Exchange (ETDEWEB)
Gobin, R.; Adroit, G.; Bogard, D.; Bourdelle, G.; Chauvin, N.; Delferriere, O.; Gauthier, Y.; Girardot, P.; Guiho, P.; Harrault, F.; Jannin, J. L.; Loiseau, D.; Mattei, P.; Roger, A.; Sauce, Y.; Senee, F.; Vacher, T. [Commissariat a l' Energie Atomique et aux Energie Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France)
2012-02-15
In the framework of the IFMIF-EVEDA project (International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities), CEA/IRFU is in charge of the design, construction, and characterization of the 140 mA continuous deuteron injector, including the source and the low energy beam line. The electron cyclotron resonance ion source which operates at 2.45 GHz is associated with a 4-electrode extraction system in order to minimize beam divergence at the source exit. Krypton gas injection is foreseen in the 2-solenoid low energy beam line. Such Kr injection will allow reaching a high level of space charge compensation in order to improve the beam matching at the radio frequency quadrupole (RFQ) entrance. The injector construction is now completed on the Saclay site and the first plasma and beam production has been produced in May 2011. This installation will be tested with proton and deuteron beams either in pulsed or continuous mode at Saclay before shipping to Japan. In this paper, after a brief description of the installation, the preliminary results obtained with hydrogen gas injection into the plasma chamber will be reported.
Community Consultation and Public Disclosure: Preliminary Results From A New Model
Ramsey, Cornelia A.; Quearry, Bonnie; Ripley, Elizabeth
2011-01-01
Emergency medicine research conducted under the exception from informed consent (EFIC) regulation enables critical scientific advancements. When EFIC is proposed, there is a requirement for broad community consultation and public disclosure regarding the risks and benefits of the study. At the present time, no clear guidelines or standards exist for conducting and evaluating the community consultation and public disclosure. This preliminary study tested the feasibility and acceptability of a new approach to community consultation and public disclosure for a large-scale EFIC trial by engaging community members in designing and conducting the strategies. The authors enrolled key community members (called Community Advocates for Research, or CARs) to use community-based participatory methods to design and implement community consultation and public disclosure. By partnering with community members who represent target populations for the research study, this new approach has demonstrated a feasible community consultation and public disclosure plan with greater community participation and less cost than previous studies. In a community survey, the percentage of community members reporting having heard about the EFIC trial more than doubled after employing the new approach. This article discusses initial implementation and results. PMID:21729187
Preliminary results of the aerosol optical depth retrieval in Johor, Malaysia
International Nuclear Information System (INIS)
Lim, H Q; Lau, A M S; Kanniah, K D
2014-01-01
Monitoring of atmospheric aerosols over the urban area is important as tremendous amounts of pollutants are released by industrial activities and heavy traffic flow. Air quality monitoring by satellite observation provides better spatial coverage, however, detailed aerosol properties retrieval remains a challenge. This is due to the limitation of aerosol retrieval algorithm on high reflectance (bright surface) areas. The aim of this study is to retrieve aerosol optical depth over urban areas of Iskandar Malaysia; the main southern development zone in Johor state, using Moderate Resolution Imaging Spectroradiometer (MODIS) 500 m resolution data. One of the important steps is the aerosol optical depth retrieval is to characterise different types of aerosols in the study area. This information will be used to construct a Look Up Table containing the simulated aerosol reflectance and corresponding aerosol optical depth. Thus, in this study we have characterised different aerosol types in the study area using Aerosol Robotic Network (AERONET) data. These data were processed using cluster analysis and the preliminary results show that the area is consisting of coastal urban (65%), polluted urban (27.5%), dust particles (6%) and heavy pollution (1.5%) aerosols
Test results with the Transrapid 06. System data from preliminary trials
Energy Technology Data Exchange (ETDEWEB)
Heinrich, K; Mnich, P
1987-10-01
Following the takeover of the Transrapid maglev facility by MVP, in spite of remaining preparatory work and conversion of the support and guidance system on the basis of a new electronic generation, interesting system data could be obtained experimentally before the planned continuous trials phase. Although the full test track length is not yet available - it is at present only 20.5 km - more than 25,000 km have already been covered in almost 1,200 test runs. Some 200 of these were for the purpose of demonstrating the Transrapid technology to visting German and foreign experts. The system data obtained from the preliminary trails were positive. Any weak points noted were mainly site-specific and not maglev-specific, but in spite of generally satisfactory results there are still many individual aspects calling for improvement and optimation before the technology can be declared ready for service. Proceeding from the positive trend of the system data obtained at up to 355 km/h, it can be said that proof of serviceability of the Transrapid transport system at speeds of up to 400 km/h can be provided in the next two years. (orig.).
Preliminary test results from the HSST shallow-crack fracture toughness program
International Nuclear Information System (INIS)
Theiss, T.J.; Robinson, G.C.; Rolfe, S.T.
1991-01-01
The Heavy Section Steel Technology (HSST) Program under sponsorship of the Nuclear Regulatory Commission (NRC) is investigating the influence of crack depth on the fracture toughness of reactor pressure vessel steel. The ultimate goal of the investigation is the generation of a limited data base of elastic-plastic fracture toughness values appropriate for shallow flaws in a reactor pressure vessel and the application of this data to reactor vessel life assessments. It has been shown that shallow-flaws play a dominant role in the probabilistic fracture mechanics analysis of reactor pressure vessels during a pressurized-thermal-shock event. In addition, recent research has shown that the crack initiation toughness measured using specimens with shallow flaws is greater that the toughness determined with conventional, deeply notched specimens at temperatures within the transition region for non-nuclear steels. The influence of crack depth on the elastic-plastic fracture toughness for prototypic reactor material is being investigated. Preliminary results indicate a significant increase in the toughness associated with shallow-flaws which has the potential to significantly impact the conditional probability of vessel failure. 8 refs., 4 figs., 1 tab
Radiolabeled antifibrin antibody in the detection of venous thrombosis: Preliminary results
International Nuclear Information System (INIS)
Alavi, A.; Palevsky, H.I.; Gupta, N.; Meranze, S.; Kelley, M.A.; Jatlow, A.D.; Schaible, T.F.; Brown, J.; Berger, H.J.
1990-01-01
The recent development of monoclonal antibodies against components of coagulated blood may provide new approaches to the diagnosis of venous thrombosis. Scanning with an indium-111-labeled Fab fragment of a murine monoclonal antifibrin antibody (59D8) and ascending contrast venography were performed in 33 patients. Images of the calves, popliteal fossae, thighs, and pelvis were obtained immediately, 4-6 hours, and 24 hours after injection of 2 mCi (74 MBq) of the antibody. All images were read in a blinded manner. Findings in both studies were positive in 28 patients and negative in three. In 19 patients not undergoing heparin therapy, 19 specific anatomic sites were positive on venograms and 29 were positive on antibody images (19 sites matched). In 14 patients undergoing heparin therapy, 34 sites were positive on venograms and 27 were positive on antibody images (22 sites matched). In most patients, positive results were noted within 1 hour of antibody injection. No adverse effects were noted with the antibody preparation. Preliminary data suggest that antifibrin antibody imaging is sensitive in detecting clots, is safe to use, and may have a role in diagnosing and managing venous thrombosis
A new confined high pressure rotary shear apparatus: preliminary results
Faulkner, D.; Coughlan, G.; Bedford, J. D.
2017-12-01
The frictional properties of fault zone materials, and their evolution during slip, are of paramount importance for determining the earthquake mechanics of large tectonic faults. Friction is a parameter that is difficult to determine from seismological methods so much of our understanding comes from experiment. Rotary shear apparatuses have been widely used in experimental studies to elucidate the frictional properties of faults under realistic earthquake slip velocities (0.1-10 m/s) and displacements (>20 m). However one technical limitation of rotary shear experiments at seismic slip rates has been the lack of confinement. This has led to a limit on the normal stress (due to the strength of the forcing blocks) and also a lack of control of measurements of the pore fluid pressure. Here we present the first preliminary results from a rotary shear apparatus that has been developed to attempt to address this issue. The new fully confined ring shear apparatus has a fast-acting servo-hydraulic confining pressure system of up to 200 MPa and a servo-controlled upstream and downstream pore pressure system of up to 200 MPa. Displacement rates of 0.01μ/s to 2 m/s can be achieved. Fault gouge samples can therefore be sheared at earthquake speed whilst being subject to pressures typically associated with the depth of earthquake nucleation.
Jackson, George L.; LaBel, Kenneth A.; Marshall, Cheryl; Barth, Janet; Seidleck, Christina; Marshall, Paul
1998-01-01
NASA Goddard Spare Flight Center's (GSFC) Dual Rate 1773 (DR1773) Experiment on the Microelectronic and Photonic Test Bed (MPTB) has provided valuable information on the performance of the AS 1773 fiber optic data bus in the space radiation environment. Correlation of preliminary experiment data to ground based radiation test results show the AS 1773 bus is employable in future spacecraft applications requiring radiation tolerant communication links.
Directory of Open Access Journals (Sweden)
Anders K. Mortensen
2017-12-01
Full Text Available The clover-grass ratio is an important factor in composing feed ratios for livestock. Cameras in the field allow the user to estimate the clover-grass ratio using image analysis; however, current methods assume the total dry matter is known. This paper presents the preliminary results of an image analysis method for non-destructively estimating the total dry matter of clover-grass. The presented method includes three steps: (1 classification of image illumination using a histogram of the difference in excess green and excess red; (2 segmentation of clover and grass using edge detection and morphology; and (3 estimation of total dry matter using grass coverage derived from the segmentation and climate parameters. The method was developed and evaluated on images captured in a clover-grass plot experiment during the spring growing season. The preliminary results are promising and show a high correlation between the image-based total dry matter estimate and the harvested dry matter ( R 2 = 0.93 with an RMSE of 210 kg ha − 1 .
Yamamoto, Hideko; Kamegaya, Etsuko; Hagino, Yoko; Takamatsu, Yukio; Sawada, Wakako; Matsuzawa, Maaya; Ide, Soichiro; Yamamoto, Toshifumi; Mishina, Masayoshi; Ikeda, Kazutaka
2017-01-01
The N-methyl-d-aspartate (NMDA) receptor channel is involved in various physiological functions, including learning and memory. The GluN2D subunit of the NMDA receptor has low expression in the mature brain, and its role is not fully understood. In the present study, the effects of GluN2D subunit deficiency on emotional and cognitive function were investigated in GluN2D knockout (KO) mice. We found a reduction of motility (i.e., a depressive-like state) in the tail suspension test and a reduction of sucrose preference (i.e., an anhedonic state) in GluN2D KO mice that were group-housed with littermates. Despite apparently normal olfactory function and social interaction, GluN2D KO mice exhibited a decrease in preference for social novelty, suggesting a deficit in social recognition or memory. Golgi-Cox staining revealed a reduction of the complexity of dendritic trees in the accessory olfactory bulb in GluN2D KO mice, suggesting a deficit in pheromone processing pathway activation, which modulates social recognition. The deficit in social recognition may result in social stress in GluN2D KO mice. Isolation housing is a procedure that has been shown to reduce stress in mice. Interestingly, 3-week isolation and treatment with agomelatine or the 5-hydroxytryptamine-2C (5-HT 2C ) receptor antagonist SB242084 reversed the anhedonic-like state in GluN2D KO mice. In contrast, treatment with the 5-HT 2C receptor agonist CP809101 induced depressive- and anhedonic-like states in isolated GluN2D KO mice. These results suggest that social stress that is caused by a deficit in social recognition desensitizes 5-HT 2c receptors, followed by an anhedonic- and depressive-like state, in GluN2D KO mice. The GluN2D subunit of the NMDA receptor appears to be important for the recognition of individuals and development of normal emotionality in mice. 5-HT 2C receptor antagonism may be a therapeutic target for treating social stress-induced anhedonia. This article is part of the Special
Preliminary results of local earthquake tomography around Bali, Lombok, and Sumbawa regions
Energy Technology Data Exchange (ETDEWEB)
Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id; Puspito, Nanang T; Yudistira, Tedi [Global Geophysical Reserach Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, JlGanesa 10, Bandung, 40132 (Indonesia); Kusnandar, Ridwan; Sakti, Artadi Pria [Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia)
2015-04-24
Bali, Sumbawa, and Lombok regions are located in active tectonic influence by Indo-Australia plate subducts beneath Sunda plate in southern part and local back-arc thrust in northern part the region. Some active volcanoes also lie from eastern part of Java, Bali, Lombok and Sumbawa regions. Previous studies have conducted subsurface seismic velocity imaging using regional and global earthquake data around the region. In this study, we used P-arrival time from local earthquake networks compiled by MCGA, Indonesia within time periods of 2009 up to 2013 to determine seismic velocity structure and simultaneously hypocenter adjustment by applying seismic tomography inversion method. For the tomographic inversion procedure, we started from 1-D initial velocity structure. We evaluated the resolution of tomography inversion results through checkerboard test and calculating derivative weigh sum. The preliminary results of tomography inversion show fairly clearly high seismic velocity subducting Indo-Australian and low velocity anomaly around volcano regions. The relocated hypocenters seem to cluster around the local fault system such as back-arc thrust fault in northern part of the region and around local fault in Sumbawa regions. Our local earthquake tomography results demonstrated consistent with previous studies and improved the resolution. For future works, we will determine S-wave velocity structure using S-wave arrival time to enhance our understanding of geological processes and for much better interpretation.
Varfarin in the complex treatment of antiphospholipid syndrome: preliminary results
Directory of Open Access Journals (Sweden)
T M Reshetnyak
2003-01-01
Full Text Available Objective. To assess efficacy and tolerance of varfarin in prophylaxis and therapy of thrombotic complications in patients with antiphospholipid syndrome (APS. Methods. 20 pts with APS (5 male and 15 female received varfarin during a year. 8 of them had primary APS (PAPS and 12 -systemic lupus erythematosus with APS (SLE+APS. 2 other pts (I with SLE+APS and I with PAPS received varfarin during the last 4 years. Nobody from 9 pts with PAPS received corticosteroids (CS. In SLE+APS pts CS dose varied from 4 to 20 mg/day and was not increased during follow up. During the study prothrombine time (PT was examined with thromboplastin ( manufactured by Renam having international sensitivity index 1,2 and international normalization relation (INR. Depending on treatment scheme APS pts were divided into 3 groups. Group 1 included 8 pts with INR<2,0, Group 2-7 with INR >3,0, group 3 - 7 pts with INR<2,0 receiving as additional treatment thrombo ASS 100 mg/day and vasonit from 600 to 1200 mg/day. Results. Two pts with INR = 1,8 had thrombosis recurrence (due to leg thrombophlebitis. There were no recurrences in other groups. 2 from 22 pts had "large" bleedings. "Small" bleedings episodes were noted in 7 from 22 pts. Largely that were subcutaneous bleedings (in 4 pts no more than 5 cm of size. Two pts receiving varfarin with INR 1,8 and 2,4 had renal colic. Conclusion. Our preliminary results prove the necessity of inclusion of varfarin in the treatment of pts with APS and thrombosis but intensive anticoagulant effect is not always desired.
Raud, Sirli; Reimets, Riin; Loomets, Maarja; Sütt, Silva; Altpere, Alina; Visnapuu, Tanel; Innos, Jürgen; Luuk, Hendrik; Plaas, Mario; Volke, Vallo; Vasar, Eero
2015-08-01
Wolfram syndrome, induced by mutation in WFS1 gene, increases risk of developing mood disorders in humans. In mice, Wfs1 deficiency cause higher anxiety-like behaviour and increased response to anxiolytic-like effect of diazepam, a GABAA receptor agonist. As GABAergic system is also target for ethanol, we analysed its anxiolytic-like and sedative properties in Wfs1-deficient mice using elevated plus-maze test and tests measuring locomotor activity and coordination, respectively. Additionally loss of righting reflex test was conducted to study sedative/hypnotic properties of ethanol, ketamine and pentobarbital. To evaluate pharmacokinetics of ethanol in mice enzymatic colour test was used. Finally, gene expression of alpha subunits of GABAA receptors following ethanol treatment was studied by real-time-PCR. Compared to wild-types, Wfs1-deficient mice were more sensitive to ethanol-induced anxiolytic-like effect, but less responsive to impairment of motor coordination. Ethanol and pentobarbital, but not ketamine, caused longer duration of hypnosis in Wfs1-deficient mice. The expression of Gabra2 subunit at 30 minutes after ethanol injection was significantly increased in the frontal cortex of Wfs1-deficient mice as compared to respective vehicle-treated mice. For the temporal lobe, similar change in Gabra2 mRNA occurred at 60 minutes after ethanol treatment in Wfs1-deficient mice. No changes were detected in Gabra1 and Gabra3 mRNA following ethanol treatment. Taken together, increased anxiolytic-like effect of ethanol in Wfs1-deficient mice is probably related to altered Gabra2 gene expression. Increased anti-anxiety effect of GABAA receptor agonists in the present work and earlier studies (Luuk et al., 2009) further suggests importance of Wfs1 gene in the regulation of emotional behaviour. Copyright © 2015 Elsevier Ltd. All rights reserved.
International Nuclear Information System (INIS)
Yokohira, Masanao; Arnold, Lora L.; Pennington, Karen L.; Suzuki, Shugo; Kakiuchi-Kiyota, Satoko; Herbin-Davis, Karen; Thomas, David J.; Cohen, Samuel M.
2010-01-01
Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes reactions which convert inorganic arsenic to methylated metabolites. This study determined whether the As3mt null genotype in the mouse modifies cytotoxic and proliferative effects seen in urinary bladders of wild type mice after exposure to inorganic arsenic. Female wild type C57BL/6 mice and As3mt KO mice were divided into 3 groups each (n = 8) with free access to a diet containing 0, 100 or 150 ppm of arsenic as arsenite (As III ). During the first week of As III exposure, As3mt KO mice exhibited severe and lethal systemic toxicity. At termination, urinary bladders of both As3mt KO and wild type mice showed hyperplasia by light microscopy. As expected, arsenic-containing granules were found in the superficial urothelial layer of wild type mice. In As3mt KO mice these granules were present in all layers of the bladder epithelium and were more abundant and larger than in wild type mice. Scanning electron microscopy of the bladder urothelium of As3mt KO mice treated with 100 ppm As III showed extensive superficial necrosis and hyperplastic changes. In As3mt KO mice, livers showed severe acute inflammatory changes and spleen size and lymphoid areas were decreased compared with wild type mice. Thus, diminished arsenic methylation in As3mt KO mice exacerbates systemic toxicity and the effects of As III on the bladder epithelium, showing that altered kinetic and dynamic behavior of arsenic can affect its toxicity.
International Nuclear Information System (INIS)
Wang Qiliang; He Miaoting; Shu Qi
1985-01-01
In this paper the preliminary results of measurement of natural environmental radiation levels in China with RSS-111 high pressure ionization chamber and estimated doses to population are reported. A total of 2,723 indoor locales throughout China were measured. The results showed that the average absorbed dose rates in air due to gamma radiation for indoors and outdoors were 11.0 x 10 -8 Gy.h -1 and 7.4 x 10 -8 Gy.h -1 , respectively, and those due to cosmic rays were 3.2 x 10 -8 Gy.h -1 and 3.7 x 10 -8 Gy.h -1 , respectively. The annual average effective dose equivalent to population was 919 μSv, including 630 μSv from natural gamma radiation and 289 μSv from cosmic rays
Burchfield, James G; Kebede, Melkam A; Meoli, Christopher C; Stöckli, Jacqueline; Whitworth, P Tess; Wright, Amanda L; Hoffman, Nolan J; Minard, Annabel Y; Ma, Xiuquan; Krycer, James R; Nelson, Marin E; Tan, Shi-Xiong; Yau, Belinda; Thomas, Kristen C; Wee, Natalie K Y; Khor, Ee-Cheng; Enriquez, Ronaldo F; Vissel, Bryce; Biden, Trevor J; Baldock, Paul A; Hoehn, Kyle L; Cantley, James; Cooney, Gregory J; James, David E; Fazakerley, Daniel J
2018-04-13
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, here we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD). HFHSD-fed mice rapidly exhibited metabolic alterations, including obesity, hyperleptinemia, physical inactivity, glucose intolerance, peripheral insulin resistance, fasting hyperglycemia, ectopic lipid deposition, and bone deterioration. Prolonged exposure to HFHSD resulted in morbid obesity, ectopic triglyceride deposition in liver and muscle, extensive bone loss, sarcopenia, hyperinsulinemia, and impaired short-term memory. Although many of these defects are typically associated with aging, HFHSD did not alter telomere length in white blood cells, indicating that this diet did not generally promote all aspects of aging. Strikingly, glucose homeostasis was highly dynamic. Glucose intolerance was evident in HFHSD-fed mice after 1 week and was maintained for 24 weeks. Beyond 24 weeks, however, glucose tolerance improved in HFHSD-fed mice, and by 60 weeks, it was indistinguishable from that of chow-fed mice. This improvement coincided with adaptive β-cell hyperplasia and hyperinsulinemia, without changes in insulin sensitivity in muscle or adipose tissue. Assessment of insulin secretion in isolated islets revealed that leptin, which inhibited insulin secretion in the chow-fed mice, potentiated glucose-stimulated insulin secretion in the HFHSD-fed mice after 60 weeks. Overall, the excessive calorie intake was accompanied by deteriorating function of numerous physiological systems. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.
Monteiro, Gaby E R; Jansen van Vuren, Petrus; Wichgers Schreur, Paul J; Odendaal, Lieza; Clift, Sarah J; Kortekaas, Jeroen; Paweska, Janusz T
2018-04-02
The NSs protein encoded by the S segment of Rift Valley fever virus (RVFV) is the major virulence factor, counteracting the host innate antiviral defence. It contains five highly conserved cysteine residues at positions 39, 40, 149, 178 and 194, which are thought to stabilize the tertiary and quaternary structure of the protein. Here, we report significant differences between clinical, virological, histopathological and host gene responses in BALB/c mice infected with wild-type RVFV (wtRVFV) or a genetic mutant having a double cysteine-to-serine substitution at residues 39 and 40 of the NSs protein (RVFV-C39S/C40S). Mice infected with the wtRVFV developed a fatal acute disease; characterized by high levels of viral replication, severe hepatocellular necrosis, and massive up-regulation of transcription of genes encoding type I and -II interferons (IFN) as well as pro-apoptotic and pro-inflammatory cytokines. The RVFV-C39S/C40S mutant did not cause clinical disease and its attenuated virulence was consistent with virological, histopathological and host gene expression findings in BALB/c mice. Clinical signs in mice infected with viruses containing cysteine-to-serine substitutions at positions 178 or 194 were similar to those occurring in mice infected with the wtRVFV, while a mutant containing a substitution at position 149 caused mild, non-fatal disease in mice. As mutant RVFV-C39S/C40S showed an attenuated phenotype in mice, the molecular mechanisms behind this attenuation were further investigated. The results show that two mechanisms are responsible for the attenuation; (1) loss of the IFN antagonistic propriety characteristic of the wtRVFV NSs and (2) the inability of the attenuated mutant to degrade Proteine Kinase R (PKR). Copyright © 2018. Published by Elsevier B.V.
Hesse, S; Werner, C; Uhlenbrock, D; von Frankenberg, S; Bardeleben, A; Brandl-Hesse, B
2001-01-01
Modern concepts of gait rehabilitation after stroke favor a task-specific repetitive approach. In practice, the required physical effort of the therapists limits the realization of this approach. Therefore, a mechanized gait trainer enabling nonambulatory patients to have the repetitive practice of a gait-like movement without overstraining therapists was constructed. This preliminary study investigated whether an additional 4-week daily therapy on the gait trainer could improve gait ability in 14 chronic wheelchair-bound hemiparetic subjects. The 4 weeks of physiotherapy and gait-trainer therapy resulted in a relevant improvement of gait ability in all subjects. Velocity, cadence, and stride length improved significantly (p gait trainer seems feasible as an adjunctive tool in gait rehabilitation after stroke; further studies are needed.
Toxicity of Lunar Dust in Lungs Assessed by Examining Biomarkers in Exposed Mice
Lam, C.-W.; James, J. T.; Zeidler-Erdely, P. C.; Castranova, V.; Young, S. H.; Quan, C. L.; Khan-Mayberry, N.; Taylor, L. A.
2010-01-01
NASA is contemplating to build an outpost on the Moon for prolonged human habitation and research. The lunar surface is covered by a layer of soil, of which the finest portion is highly reactive dust. Dust samples of respirable sizes were aerodynamically isolated from two lunar soil samples of different maturities (cosmic exposure ages) collected during the Apollo 16 mission. The lunar dust samples, TiO2, or quartz, suspended in normal saline were given to groups of 5 C57 male mice by intrapharyngeal aspiration at 0. 1, 0.3, or 1.0 mg/mouse. Because lunar dust aggregates rapidly in aqueous media, some tests were conducted with dusts suspended in Survanta/saline (1:1). The mice were euthanized 7 or 30 days later, and their lungs were lavaged to assess the presence of toxicity biomarkers in bronchioalveolar lavage fluids. The overall results showed that the two lunar dust samples were similar in toxicity, they were more toxic than T102 , but less toxic than quartz. This preliminary study is a part of the large study to obtain data for setting exposure limits for astronauts living on the Moon
De Pasquale, Francesco; Caravasso, Chiara Falletta; Péran, Patrice; Catani, Sheila; Tuovinen, Noora; Sabatini, Umberto; Formisano, Rita
2015-01-01
The aim of this preliminary study was to present a new approach for connectivity analysis in patients with severe acquired brain injury (ABI) that overcomes some of the difficulties created by anatomical abnormalities due to the brain injury. Using a data-driven approach, resting-state structural MRI (sMRI) and functional MRI (fMRI) data from three severe ABI patients - two with disorders of consciousness (DOC) and one who had recovered consciousness (non-DOC) - were integrated and analyzed. Parameters extracted from the distribution of the connectivity values, such as mean, standard deviation and skeweness, were considered. The distribution parameters estimated seem to provide an accurate multivariate classification of the considered cases that can be summarized as follows: connectivity in the severe ABI patients with DOC was on average lower than in the severe ABI non-DOC patient and healthy subjects. The dispersion of connectivity values of the severe ABI patients, non-DOC and DOC, was comparable, however the shape of the distribution was different in the non-DOC patient. Eventually, seed-based connectivity maps of the default mode Functional magnetic resonance imaging in disorders of consciousness: preliminary results of an innovative analysis of brain connectivity network show a pattern of increasing disruption of this network from the healthy subjects to non-DOC and DOC patients. Consistent results are obtained using an ICA-based approach..
Directory of Open Access Journals (Sweden)
Hassani Kamran
2011-05-01
Full Text Available Abstract Background Although cardiac auscultation remains important to detect abnormal sounds and murmurs indicative of cardiac pathology, the application of electronic methods remains seldom used in everyday clinical practice. In this report we provide preliminary data showing how the phonocardiogram can be analyzed using color spectrographic techniques and discuss how such information may be of future value for noninvasive cardiac monitoring. Methods We digitally recorded the phonocardiogram using a high-speed USB interface and the program Gold Wave http://www.goldwave.com in 55 infants and adults with cardiac structural disease as well as from normal individuals and individuals with innocent murmurs. Color spectrographic analysis of the signal was performed using Spectrogram (Version 16 as a well as custom MATLAB code. Results Our preliminary data is presented as a series of seven cases. Conclusions We expect the application of spectrographic techniques to phonocardiography to grow substantially as ongoing research demonstrates its utility in various clinical settings. Our evaluation of a simple, low-cost phonocardiographic recording and analysis system to assist in determining the characteristic features of heart murmurs shows promise in helping distinguish innocent systolic murmurs from pathological murmurs in children and is expected to useful in other clinical settings as well.
Principle and preliminary results of the whole-body scintigraphic unit Omniview
International Nuclear Information System (INIS)
Methlin, G.; Jung, G.M.; Gerard, G.
The Picker Company has recently launched a system adapted to its Dynacamera for the production of whole-body scintigraphs. For the last few months the radioisotopes service of the Strasbourg Anti-Cancer Centre has been in possession of such a system, intended mainly for systematic research on metastases, especially of the bone, and on the degree of extension of tumours. On the basis of the short experience so far acquired the report is limited to an outline of the working principle of this device, the presentation of preliminary documents and a few critical remarks summing up first impressions [fr
Obada, Teodor; van der Plicht, Johannes; Markova, Anastasia; Prepelitsa, Afanasie
2012-01-01
Preliminary results are presented from the studies of a newly found Paleolithic site - Valea Morilor (Chisingu, Republic of Moldova). The excavations produced unquestionable evidence of mammoth hunting (Mammuthus primigenius Blumenbach, 1799). Excavations of 2009-2010 opened an area of 1264 m(2).
Serum Anti-Vibrio cholerae Immunoglobulin Isotype in BALB/c Mice Immunized With ompW-Loaded Chitosan
Directory of Open Access Journals (Sweden)
Mahdi Fasihi-Ramandi
2016-05-01
Full Text Available Background: Chitosan, a liner polysaccharide, is a biocompatible and safe material for the delivery of therapeutic proteins and antigens, particularly via mucosal systems. Objectives: In this study, the production of antibodies in response to outermembrane protein W (ompW-loaded chitosan in BALB/c mice was evaluated. Materials and Methods: Mice were subjected to intraperitoneal injection of ompW or nasal administration of ompW-loaded chitosan on days 1, 14, and 28, and the antibodies were measured on day 42 with ELISA. Results: The titration of antibodies indicated that the nasal administration of ompW-loaded chitosan was better able to stimulate the immune response compared to intraperitoneal injections. However, the titration of total and IgG isotypes showed a significant difference between intraperitoneal and nasal immunization (P < 0.01. A significant difference was also seen in serum IgA isotypes at over 1/80 titrations, but not at lower dilutions (P < 0.01. Despite the serum antibodies, the results of lavage fluid analysis revealed that the IgG and IgA isotypes in the mice subjected to nasal immunization with ompW-loaded chitosan were significantly higher than in the other group (P < 0.01. Conclusions: Based on the preliminary results presented in this research, it is suggested that ompW-loaded chitosan could be a suitable choice for nasal application to immunize the host against Vibrio cholerae. However, more work is required to determine the efficiency of the antibodies in neutralizing the bacterial toxin or bacterial movement.
Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada.
Thomas, Gerald; Lucas, Philippe; Capler, N Rielle; Tupper, Kenneth W; Martin, Gina
2013-03-01
This paper reports results from a preliminary observational study of ayahuasca-assisted treatment for problematic substance use and stress delivered in a rural First Nations community in British Columbia, Canada. The "Working with Addiction and Stress" retreats combined four days of group counselling with two expert-led ayahuasca ceremonies. This study collected pre-treatment and six months follow-up data from 12 participants on several psychological and behavioral factors related to problematic substance use, and qualitative data assessing the personal experiences of the participants six months after the retreat. Statistically significant (p ayahuasca-assisted therapy appears to be associated with statistically significant improvements in several factors related to problematic substance use among a rural aboriginal population. These findings suggest participants may have experienced positive psychological and behavioral changes in response to this therapeutic approach, and that more rigorous research of ayahuasca-assisted therapy for problematic substance use is warranted.
Moore, Alan D.; Lee, S.M.C.; Everett, M.E.; Guined, J.R.; Knudsen, P.
2010-01-01
Maximum oxygen uptake (VO2max) is reduced immediately following space flights lasting 6%. WRmax also decreased on R+1/2 compared to preflight (Pre: 245+/-69, R+1/2: 210+/-45 W). On R+10, VO2max was 2.86+/-0.62 L(dot)/min, with 2 subjects still demonstrating a loss of > 6% from preflight. WRmax on R+10 was 240+/-49 W. HRmax did not change from pre to post-flight. Conclusions: These preliminary results, from the first 5 of 12 planned subjects of an ongoing ISS study, suggest that the majority of astronauts will experience a decrease in VO2max after long-duration space-flight. Interestingly, the two astronauts with the highest preflight VO2max had the greatest loss on R+1/2, and the astronaut with the lowest preflight VO2max increased by 13%. Thus, maintenance of VO2max may be more difficult in astronauts who have a high aerobic capacity, perhaps requiring more intense in-flight exercise countermeasure prescriptions.
Shaping the future of production in South Africa: Preliminary country readiness results
CSIR Research Space (South Africa)
Saunders, M
2017-10-01
Full Text Available • Digital Security & Data Privacy • Industry Activity • Research Intensity • Available Financing • Labor Force Skills • Inclusivity • Migration • Education Outcomes • Agility & Adaptability • Trade Linkages • Trade Performance • Trade... and target sectors and value chain segments for growth 10 PRELIMINARY – FOR DISCUSSION High Potential Followers Legacy Champions Global Leaders Sectors Where to target growth? Value Chain Which segments to focus on? Inclusive Growth How to support...
Directory of Open Access Journals (Sweden)
Yasushi Ishijima
2014-01-01
Full Text Available Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the KitW-sh/W-sh stromal vascular fraction, suggesting the accumulation of preadipocytes. Moreover, the increased expression of preadipocyte genes was restored by mast cell reconstitution in the KitW-sh/W-sh mice. These results suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions.
Energy Technology Data Exchange (ETDEWEB)
Kondrat' eva, T K; Fontalin, L N; Nagurskaya, E V; Novikova, T K; Blandova, Z K; Chernousov, A D [Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii
1979-05-01
The immunologic reactivity of mouse (CBAxM523)F/sub 1/ lymphocytes to alien antigens (ram erythrocytes) in the organisms of lethally irradiated CBA mice was studied. If the irradiation, cell transfer and antigen test-injection were performed on the same day, the activity of the transplant was suppressed as compared to the syngenic system. If the intervals between these procedures increased to three days the activity of donor cells was recovered. The retransplantation of recipient spleen cells to the irradiated CBA and F/sub 1/ mice demonstrated the viability of the transplanted cells and the absence of their transadaptation to nonsyngenic microenvironment. The resistance of the recipients could be overcome specifically by preliminary injection of F/sub 1/ mouse cells in combination with cyclophosphamide or without it. The results obtained suggest to conclude, that the genetic parental resistance of CBA mice to F/sub 1/ mouse cells is caused by the immunologically competent recipient cells that are inactivated after three days following irradiation. They do not produce a cytotoxic effect on donor cells, but limit temporarily the activity of the latter.
Energy Technology Data Exchange (ETDEWEB)
McCay Timothy, S.; Hanula, James, L.; Loeb, Susan, C.; Lohr, Steven, M.; McMinn, James, W.; Wright-Miley. Bret, D.
2002-08-01
McCay, Timothy S., James L. Hanula, Susan C. Loeb, Steven M. Lohr, James W. McMinn, and Bret D. Wright-Miley. 2002. The role of coarse woody debris in southeastern pine forests; preliminary results from a large-scale experiment. 135-144. In: Proceedings of the symposium on the ecology and management of dead wood in western forests. 1999 November 2-4; Reno, NV. Gen. Tech. Rep. PSW-GTR-181. Albany, CA: Pacific Southwest Research Station, Forest Service, U.S. Department of Agriculture 949 p. ABSTRACT: We initiated a long-term experiment involving manipulation of coarse woody debris (CWD) at the Savannah River National Environmental Research Park in the upper Coastal Plain of South Carolina. Each of four 9.3-ha plots in each of four blocks was subject to one of the following treatments: removal of all snags and fallen logs, removal of fallen logs only, felling and girdling to simulate a catastrophic pulse of CWD, and control. Removal treatments were applied in 1996, and the felling or snag-creation treatment will be applied in 2000-2001. Monitoring of invertebrate, herptile, avian, and mammalian assemblages and CWD dynamics began immediately after CWD removal and continues through the present. Removal treatments resulted in a fivefold to tenfold reduction in CWD abundance. To date, significant differences among treatments have only been detected for a few animal taxa. However, preliminary results underscore the benefits of large-scale experiments. This experiment allowed unambiguous tests of hypotheses regarding the effect of CWD abundance on fauna. Coupled with studies of habitat use and trophic interactions, the experimental approach may result in stronger inferences regarding the function of CWD than results obtained through natural history observation or uncontrolled correlative studies.
Intraarterial Ultrasound in Pancreatic Cancer: Feasibility Study and Preliminary Results
International Nuclear Information System (INIS)
Larena-Avellaneda, Axel; Timm, Stephan; Kickuth, Ralph; Kenn, Werner; Steger, Ulrich; Jurowich, Christian; Germer, Christoph-Thomas
2010-01-01
Despite technological advances in computed tomography (CT) and magnetic resonance imaging, the involvement of the celiac or mesenteric artery in pancreatic cancer remains uncertain in many cases. Infiltration of these vessels is important in making decisions about therapy choices but often can only be definitively determined through laparotomy. Local (intraarterial) ultrasound may increase diagnostic accuracy. Using the Volcano intravascular ultrasound (IVUS) system, we applied a transfemoral method to scan the celiac and mesenteric arteries directly intraarterial. This technique was used in five patients with suspected pancreatic cancer. Technical success was achieved in all cases. In one case, a short dissection of the mesenteric artery occurred but could be managed interventionally. In tumors that did not contact with the vessels, IVUS was unable to display the tissue pathology. Our main interest was the infiltration of the arteries. In one case, infiltration was certain in the CT scan but uncertain in two patients. In the latter two cases, IVUS correctly predicted infiltration in one and freedom from tumor in the other case. In our preliminary study, IVUS correctly predicted arterial infiltration in all cases. IVUS did not provide new information when the tumor was far away from the vessel. Compared with IVUS in the portal vein, the information about the artery is more detailed, and the vessel approach is easier. These results encouraged us to design a prospective study to evaluate the sensitivity and specificity of this method.
Preliminary results from a high-pressure imaging spectroscopic proportional counter
International Nuclear Information System (INIS)
Hall, C.J.; Bazzano, A.; Lewis, R.A.; Parker, B.; Ubertini, P.; Worgan, J.S.
1992-01-01
A new type of high-pressure proportional counter, with both spatial resolution and spectroscopic capabilities is being jointly developed by the Istituto di Astrofisica Spaziale (CNR), Frascati, Italy and the SERC Daresbury Laboratory, Warrington, UK. The characteristics of the detector can be optimized for the particular requirement of the experiment, either for x-ray astronomy observations from space, or for the high count rate applications associated with a synchrotron light source. In its baseline configuration, the detector is filled to 5 bar with a xenon/quench gas mixture and will be sensitive over the energy range 5 keV to 150 keV (2.5 to 0.08 A). The positional resolution will range from 500 μm at the lower energies to around 1 mm at the higher end of the energy range. The current prototype has a sensitive area of 200x200 mm. The final version is hoped to have an area closer to 425x425 mm. The very small photon absorption length in the higher pressure gas allows the parallax effect, a feature of 1 atmosphere detectors, to be greatly reduced. The timing resolution (150 ns) of the detector enables both a high-rate capability and the possibility of the escape gate technique to achieve higher spectral resolution at energies > the Xe K edge. Preliminary results are presented showing the spectral and positional resolution for the prototype detector
International Nuclear Information System (INIS)
Ju, Jihyeung; Nolan, Bonnie; Cheh, Michelle; Bose, Mousumi; Lin, Yong; Wagner, George C; Yang, Chung S
2008-01-01
Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, Apc Min/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. In Experiments 1 and 2, five-week old female Apc Min/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks. In the Apc Min/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In Apc Min/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E 2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors. These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in Apc Min/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism
International Nuclear Information System (INIS)
Han, Young-Min; Hwang, Seung-Bae; Lee, Soo-Teik; Lee, Jeong-Min; Chung, Gyung-Ho
2002-01-01
Purpose: To evaluate the immediate and long-term results in ten patients with malignant biliary obstruction using a polyurethane-covered, self-expandable nitinol stent.Methods: A nitinol stent, fully covered with high-elasticity polyurethane, with an unconstrained diameter of 10 mm and a total length of 60-80 mm, was placed transhepatically under fluoroscopic guidance in ten patients. The length of the biliary obstruction varied between 30-50 mm. The follow-up examination included a clinical assessment, serum bilirubin measurement, and ultrasound examinations at one-month intervals in all patients. Results: Initial stent deployment was successful in eight patients. Two patients experienced proximal migration,which was solved by insertion of two, uncovered Wallstents. One patient had the stent removed after two weeks because of severe nausea and vomiting. One patient had delayed migration of the covered stent after 40 weeks. The follow-up duration was 3-40 weeks (Mean: 16.9 weeks). Seven patients died(3-26 weeks) and three patients survived (24-40 weeks). The bilirubin measurements in all patients had significantly decreased one week after stent insertion. The levels of amylase and lipase had did not increase after stent insertion. Conclusions: Apolyurethane-covered, self-expandable nitinol stent can be used effectively and safely in the treatment of malignant biliary obstruction. The preliminary results are favorable, but there is a need for further large studies to determine both long-term survival and patency
Tissue distribution of tritiated digoxin and quabain in mice
International Nuclear Information System (INIS)
Klopper, J.F.; Atkins, H.L.
1976-01-01
Tissue concentration of tritiated digoxin in human subjects appears to be selective in that after a single dose of the radioactive tracer a myocardial concentration of digoxin on an average 24 to 30 times higher than the serum concentration is reached. In patients studied 3.5 to 84 hours after administration of tritiated digoxin, the dose in the heart was found to vary between 1.95 to 4.83 percent. Should it be possible to label digoxin or another cardiac glycoside with a suitable gamma-emitting tracer, its use as a cardiac imaging agent should thus be feasible. This study was undertaken to determine the tissue distribution in mice of tritiated digoxin at various time intervals post injection; and to determine if these values showed any correlation to the previously determined human data. A preliminary study in mice using 3 H-digitoxin revealed no selective uptake in the heart with high uptakes in the liver and gut. Since ouabain has a more rapid clinical onset of action than digoxin, its tissue distribution was included in the study and compared to that of digoxin
Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results
Bigio, Irving J.; Brown, Stephen G.; Briggs, Gavin M.; Kelley, Christine; Lakhani, Sunil; Pickard, David; Ripley, Paul M.; Rose, Ian; Saunders, Christobel
2000-04-01
We report on the first stages of a clinical study designed to test elastic-scattering spectroscopy, medicated by fiberoptic probes, for three specific clinical applications in breast-tissue diagnosis: (1) a transdermal-needle (interstitial) measurement for instant diagnosis with minimal invasiveness similar to fine-needle aspiration but with sensitivity to a larger tissue volume, (2) a hand-held diagnostic probe for use in assessing tumor/resection margins during open surgery, and (3) use of the same probe for real-time assessment of the `sentinel' node during surgery to determine the presence or absence of tumor (metastatic). Preliminary results from in vivo measurements on 31 women are encouraging. Optical spectra were measured on 72 histology sites in breast tissue, and 54 histology sites in sentinel nodes. Two different artificial intelligence methods of spectral classification were studied. Artificial neural networks yielded sensitivities of 69% and 58%, and specificities of 85% and 93%, for breast tissue and sentinel nodes, respectively. Hierarchical cluster analysis yielded sensitivities of 67% and 91%, and specificities of 79% and 77%, for breast tissue and sentinel nodes, respectively. These values are expected to improve as the data sets continue to grow and more sophisticated data preprocessing is employed. The study will enroll up to 400 patients over the next two years.
Doses in pediatric patients undergoing chest and abdomen CT examinations. Preliminary results
International Nuclear Information System (INIS)
Jornada, Tiago S.; Silva, Teogenes A. da
2011-01-01
Computed tomography (CT) is a non-invasive method of image production that imparts significant doses to a patient, it is expected that pediatric CT examinations will increase the risk of induced cancer in children. In this study the effective doses in a five year-old child submitted to chest or abdomen CT scans were assessed for comparison purposes. The CTEXPO computed program was used with data from routine protocols of a 0 to 13 year-old children in two public hospitals in Belo Horizonte. Hospital A used a Siemens Dual-Slice unit with 80 kV, 41 mA and pitch 2 for chest or abdomen; hospital B used a Multislice GE unit with 120 kV, 45 mA and pitch 1 for chest and 120 kV, 55 mA. and pitch 1 for abdomen. Results of effective doses in a five year-old child were 1.7 and 1.0 mSv in hospital A and 9.1 and 7.2 mSv in hospital B, for chest and abdomen, respectively. Results were compared to the reference effective doses of 7.2 and 5.0 mSv for chest and abdomen respectively that were derived from the air kerma length product values given in ICRP publication 87. Results of hospital A showed that low dose exposures also can be achieved in CT scans of children. Results showed that even a hospital with a modern facility (hospital B) can provided doses higher than reference values if protocols are not adjusted for children. Preliminary results suggested that there is a room for optimizing children exposure submitted to CT scans. (author)
Environment modelling in near Earth space: Preliminary LDEF results
Coombs, C. R.; Atkinson, D. R.; Wagner, J. D.; Crowell, L. B.; Allbrooks, M.; Watts, A. J.
1992-01-01
Hypervelocity impacts by space debris cause not only local cratering or penetrations, but also cause large areas of damage in coated, painted or laminated surfaces. Features examined in these analyses display interesting morphological characteristics, commonly exhibiting a concentric ringed appearance. Virtually all features greater than 0.2 mm in diameter possess a spall zone in which all of the paint was removed from the aluminum surface. These spall zones vary in size from approximately 2 - 5 crater diameters. The actual craters in the aluminum substrate vary from central pits without raised rims, to morphologies more typical of craters formed in aluminum under hypervelocity laboratory conditions for the larger features. Most features also possess what is referred to as a 'shock zone' as well. These zones vary in size from approximately 1 - 20 crater diameters. In most cases, only the outer-most layer of paint was affected by this impact related phenomenon. Several impacts possess ridge-like structures encircling the area in which this outer-most paint layer was removed. In many ways, such features resemble the lunar impact basins, but on an extremely reduced scale. Overall, there were no noticeable penetrations, bulges or spallation features on the backside of the tray. On Row 12, approximately 85 degrees from the leading edge (RAM direction), there was approximately one impact per 15 cm(exp 2). On the trailing edge, there was approximately one impact per 72 cm(exp 2). Currently, craters on four aluminum experiment trays from Bay E09, directly on the leading edge are being measured and analyzed. Preliminary results have produced more than 2200 craters on approximately 1500 cm(exp 2) - or approximately 1 impact per 0.7 cm(exp 2).
Microtia is a reduction in pinna size, usually seen in humans in conjunction with other medical conditions. Here we report microtia in CD-1 mice following gestational exposure to ethane dimethanesulfonate (EDS), an alkylating agent and adult rat Leydig cell toxicant. Methods...
Energy Technology Data Exchange (ETDEWEB)
Hewitt, G. F.; Sharratt, E. W.
1962-10-15
Preliminary results are reported from an experimental study of the effect of burnoff on the diffusivity of oxygen in nitrogen within the pores of graphite. It is found that the ratio of effective diffusivity to ''free gas'' diffusivity changes about four-fold in the range 0-9% total oxidation. The viscous permeability, B0, increases in almost the same proportion over the same range.
Hydroxyurea treatment inhibits proliferation of Cryptococcus neoformans in mice
Directory of Open Access Journals (Sweden)
Kaushlendra eTripathi
2012-05-01
Full Text Available The fungal pathogen Cryptococcus neoformans (Cn is a serious threat to immunocompromised individuals, especially for HIV patients who develop meningoencephalitis. For effective cryptococcal treatment, novel antifungal drugs or innovative combination therapies are needed. Recently, sphingolipids have emerged as important bioactive molecules in the regulation of microbial pathogenesis. Previously we reported that the sphingolipid pathway gene, ISC1, which is responsible for ceramide production, is a major virulence factor in Cn infection. Here we report our studies of the role of ISC1 during genotoxic stress induced by the antineoplastic hydroxyurea (HU and methylmethane sulfonate (MMS, which affect DNA replication and genome integrity. We observed that Cn cells lacking ISC1 are highly sensitive to HU and MMS in a rich culture medium. HU affected cell division of Cn cells lacking the ISC1 gene, resulting in cell clusters. Cn ISC1, when expressed in a Saccharomyces cerevisiae (Sc strain lacking its own ISC1 gene, restored HU resistance. In macrophage-like cells, although HU affected the proliferation of WT Cn cells by 50% at the concentration tested, HU completely inhibited Cn isc1-delta cell proliferation. Interestingly, our preliminary data show that mice infected with WT or Cn isc1-delta cells and subsequently treated with HU had longer lifespans than untreated, infected control mice. Our work suggests that the sphingolipid pathway gene, ISC1, is a likely target for combination therapy with traditional drugs such as HU.
242Pu: Preliminary evaluation with consideration of 240Pu, and some sensitivity results
International Nuclear Information System (INIS)
Jary, J.; Lagrange, C.; Philis, C.
1978-01-01
A preliminary evaluation of 242 Pu nuclear data is presented for the neutron energy range from 10 keV to 20 MeV. The fission cross section is based upon recent experimental measurements on 242 Pu. The remaining cross sections have been calculated using various nuclear models with parameters obtained mainly by both fits on 240 Pu experimental data and general reflexions on the actinides. Particular care has been taken of the direct interactions. The laws of secondary neutron energy spectra and the average number of neutrons produced per fission have been evaluated. The results have been placed in ENDF/BIV format and combined with the low energy region of ENDF/BIV MAT = 1161 data to make complete the evaluation over the whole energy range 10 -5 eV - 20 MeV. Finally, the sensitivities of some of these nuclear data available for reactor calculations are given in terms of the variation of the calculated critical masses
International Nuclear Information System (INIS)
Yaneva-Sirakova, T.; Tarnovska-Kadreva, R.; Traykov, L.; Zlatareva, D.
2012-01-01
Arterial hypertension is the leading risk factor for cognitive impairment, but it is developed only in some of the patients with pour control. On the other hand, not all of the patents with white matter changes have cognitive deficit. There may be a variety of reasons for this: the accuracy of methods for blood pressure measurement, the specific brain localization or some other reason. Here are the preliminary results of a study (or the potential correlation between self-measured, office-, ambulatory monitored blood pressure, central aortic blood pressure, minimal cognitive impairment and the specific brain image on contrast computer tomography. We expect to answer, the question whether central aortic or self-measured blood pressure have the leading role for the development of cognitive impairment in the presence of a specific neuroimaging finding, as well as what is the prerequisite for the clinical manifestation of cognitive dysfunction in patients with computer tomographic pathology. (authors)
Preliminary Report: DESiGN and Test Result of KSR-3 Rocket Magnetometers
Directory of Open Access Journals (Sweden)
Hyo-Min Kim
2000-12-01
Full Text Available The solar wind contributes to the formation of unique space environment called the Earth's magnetosphere by various interactions with the Earth's magnetic field. Thus the solar-terrestrial environment affects the Earth's magnetic field, which can be observed with an instrument for the magnetic field measurement, the magnetometer usually mounted on the rocket and the satellite and based on the ground observatory. The magnetometer is a useful instrument for the spacecraft attitude control as well as the Earth's magnetic field measurements for a scientific purpose. In this paper, we present the preliminary design and test results of the two onboard magnetometers of KARI's (Korea Aerospace Research Institute sounding rocket, KSR-3, which will be launched four times during the period of 2001-02. The KSR-3 magnetometers consist of the fluxgate magnetometer, MAG/AIM (Attitude Information Magnetometer for acquiring the rocket flight attitude information, and of the search-coil magnetometer, MAG/SIM (Scientific Investigation Magnetometer for the observation of the Earth's magnetic field fluctuations. With the MAG/AIM, the 3-axis attitude information can be acquired by the comparison of the resulting dc magnetic vector field with the IGRF (International Geomagnetic Reference Field. The Earth's magnetic field fluctuations ranging from 10 to 1,000 Hz can also be observed with the MAG/SIM measurement.
Therapy of neuroendocrine carcinoma with Y-90 DOTA- preliminary results
International Nuclear Information System (INIS)
Artiko, V.; Obradovic, V.; Nadezda, N.; Djokic, D.; Jankovic, D.; Popovic, B.; Damjanovic, S.; Mikolajczak, R.; Pawlak, D.
2007-01-01
Full text: Aim: Cell membrane-specific somatostatin receptors are usually expressed by neuroendocrine tumors. Radiolabelled receptor-binding somatostatin analogues target tissues expressing these receptors and can be used for visualization and treatment. After the localization of tumors bearing somatostatin receptors with 111In or 99mTc labeled somatostatin analogues, in the case of high tumor uptake related to non target tissues, different radioisotopes have been used for their treatment. Thus, application of high doses of 111In- DTPA-octreotide had an impact on improvement of the clinical symptoms, without significant reduction of the tumor mass. However, 90Y somatostatin analogues (DOTA TOC, lanreotide) may be more effective for reduction of the tissue of the larger tumors while 177Lu labeled ones may be applied in smaller tumors. Combination of both of them seems to be the most effective therapy, particularly in tumors bearing both small and large lesions. The aim of this work is presentation of the preliminary results of the therapy of NETs with another octreotide analogue, 90Y DOTA TATE, which so far has been proved to have high therapeutic potential when labeled with 177Lu. Patients and methods: We investigated 7 patients with neuroendocrine tumors (two patients had neuroendocrine pancreatic carcinomas with liver metastases (one of them had metastases in peritoneal lymph nodes), one patient with operated (resected) bronchial carcinoid and liver metastases, three patients with neuroendocrine carcinomas of unknown origin and hepatic metastases (one with skeletal metastases) and one with pancreatic gastrinoma without metastases (surgery was impossible to perform). In all of them, together with other laboratory analyses and imaging methods, scintigraphy with somatostatin analogues was performed (in 3 with 111In Octreoscan and in the other 4 with 99mTc HYNIC TOC) and high tumor uptake was observed. The therapy was performed with 2- 4,5 GBq 90Y DOTA TATE per
Measurement of pressure ridges in SAR images of sea ice - Preliminary results on scattering theory
Vesecky, J. F.; Smith, M. P.; Daida, J. M.; Samadani, R.; Camiso, J. C.
1992-01-01
Sea ice ridges and keels (hummocks and bummocks) are important in sea ice research for both scientific and practical reasons. A long-term objective is to make quantitative measurements of sea ice ridges using synthetic aperture radar (SAR) images. The preliminary results of a scattering model for sea ice ridge are reported. The approach is through the ridge height variance spectrum Psi(K), where K is the spatial wavenumber, and the two-scale scattering model. The height spectrum model is constructed to mimic height statistics observed with an airborne optical laser. The spectrum model is used to drive a two-scale scattering model. Model results for ridges observed at C- and X-band yield normalized radar cross sections that are 10 to 15 dB larger than the observed cross sections of multiyear ice over the range of angles of incidence from 10 to 70 deg.
DEFF Research Database (Denmark)
Blat, Josep; Sayago, Sergio; Kälviäinen, Mirja
2011-01-01
addresses this issue by drawing on an ethnographical study of ICT use conducted with over 120 people, aged 67-71, in four European countries: Finland, Denmark, Italy and Spain, over a 6-month period. The preliminary results show that making a social, independent and worth use of ICT are common aspects...... across the four countries, despite the so-called heterogeneity of older people as ICT users. This short paper also touches on two key aspects which emerged from the study, engaging older people in research and the evolution of some barriers to technology use....
Ozburn, Angela Renee; Harris, R. Adron; Blednov, Yuri A.
2013-01-01
The continuous two bottle choice test is the most common measure of alcohol consumption but there is remarkably little information about the development of tolerance or dependence with this procedure. We showed that C57BL/6JxFVB/NJ and FVB/NJxC57BL/6J F1 hybrid mice demonstrate greater preference for and consumption of alcohol than either parental strain. In order to test the ability of this genetic model of high alcohol consumption to produce neuroadaptation, we examined development of alcohol tolerance and dependence after chronic self-administration using a continuous access two-bottle choice paradigm. Ethanol-experienced mice stably consumed about 16–18 g/kg/day of ethanol. Ethanol-induced withdrawal severity was assessed (after 59 days of drinking) by scoring handling-induced convulsions; withdrawal severity was minimal and did not differ between ethanol-experienced and -naïve mice. After 71 days of drinking, the rate of ethanol clearance was similar for ethanol-experienced and -naïve mice. After 77 days of drinking, ethanol-induced loss of righting reflex (LORR) was tested daily for 5 days. Ethanol-experienced mice had a shorter duration of LORR. For both ethanol-experienced and -naïve mice, blood ethanol concentrations taken at gain of righting reflex were greater on day 5 than on day 1, indicative of tolerance. After 98 days of drinking, ethanol-induced hypothermia was assessed daily for 3 days. Both ethanol-experienced and –naïve mice developed rapid and chronic tolerance to ethanol-induced hypothermia, with significant group differences on the first day of testing. In summary, chronic, high levels of alcohol consumption in F1 hybrid mice produced rapid and chronic tolerance to both the sedative/hypnotic and hypothermic effects of ethanol; additionally, a small degree of metabolic tolerance developed. The development of tolerance supports the validity of using this model of high alcohol consumption in genetic studies of alcoholism. PMID:23313769
Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results
International Nuclear Information System (INIS)
Korkmaz, A.; Yaren, H.; Kunak, I.; Uysal, B.; Kurt, B.; Topal, T.
2009-01-01
The pathogenesis of sulfur mustard (SM) toxicity is not fully understood, although it is related to reactive oxygen and nitrogen species, oxidative stress, DNA damage, poly (ADP-ribose) polymerase activation within the affected cell. We, therefore, made an attempt whether epigenetic aberrations may contribute to pathogenesis of SM poisoning in rats' lung. A total of 40 male SD rats were divided into 4 groups. Group 1 served as control and given 2 ml saline, three groups received single dose of mechlorethamine (MEC) (3.5 mg/kg subcutaneously) with the same time intervals. Group 2 received MEC only; group 3 received histone deacetylase (HDAC) inhibitor (Trichostatine A) (1 mg/kg) and group 4 received DNA methyl transferase (DNMT) inhibitor (5-Azacytidine) (0.02 mg/kg), intraperitoneally. MEC injection resulted in severe lung toxicity with strong interstitial and alveolar edema, hemorrhage, emphysematous changes as well as mild inflammatory cell infiltration and septal thickening. In group 3, the HDAC inhibitor significantly reduced interstitial and alveolar edema, hemorrhage and inflammatory cell infiltration. On the other hand, we have observed severe lung damage by using DNMT inhibitor (group 4). In HDAC inhibitor group, the results were close to sham group. In DNMT inhibitor group, however, lungs were worse than MEC group results. These preliminary results revealed that, SM itself and/or its intracellular metabolites may perturb the epigenetic environment of the affected cell in lung tissue. Hypothetically, MEC may cause HDAC induction leading to a variety of gene silencing. Trichostatine A can reduce the active enzyme level and can reactivate the already silenced genes. Further studies are needed to clarify the involvement of epigenetic perturbations in the pathogenesis of mustard toxicity.(author)
Energy Technology Data Exchange (ETDEWEB)
Furuta, T.; Masuda, T.; Tsurita, Y.; Hashimoto, A.; Miyajima, N. [Department of Nuclear Engineering, Nagoya University, Nagoya, Aichi (Japan); Sakane, H.; Shibata, M.; Yamamoto, H.; Kawade, K.
1999-03-01
A d-D gas target producing monoenergetic neutrons has been constructed for measurement of activation cross sections in the energy region of 3 to 7 MeV at Van de Graaff accelerator of Nagoya University. Neutron spectra and neutron fluxes were measured as a function of the incident deuteron energy. Preliminary results of activation cross sections were obtained for reactions {sup 27}Al(n, p){sup 27}Mg, {sup 27}Al(n, {alpha}){sup 24}Na, {sup 47}Ti(n, p){sup 47}Sc, {sup 56}Fe(n, p){sup 56}Mn, {sup 58}Ni(n, p){sup 58}Co and {sup 64}Zn(n, p){sup 64}Cu. The results are compared with the evaluated values of JENDL-3.2. A well-type HPGe detector was used for highly efficient detection. (author)
Intraspecific variability of European larch for wood properties: Preliminary results
Energy Technology Data Exchange (ETDEWEB)
Paques, L.E.; Rozenberg, P. [Institut National de Recherches Agronomiques (INRA), 45 - Olivet (France). Station d`Amelioration des Arbres Forestiers
1995-12-31
Wood properties of several natural populations of European larch (Larix decidua Mill) were determined from samples collected in one replicate of the II. International IUFRO provenance experiment, planted in Brittany in 1959. According to provenances, proportion of heartwood ranges from 35 to 58% of basal area, basic density from 442 to 505 g/dm{sup 3} and Young modulus of elasticity from 8474 to 14522 MPa. Positive correlations between girth and heartwood proportion and between wood density and modulus of elasticity but negative correlations between ring width and both density and MOE have been found both at the individual and at the population levels. Variability between and within provenances is high for two major traits (proportion of heartwood and Young modulus of elasticity) for which a SW - NE gradient is shown. For wood density parameters including pilodyn, a greater homogeneity is observed. Besides a now largely recognized superiority for growth traits, Central European populations from the Sudetan Mountains and Central Poland would also produce wood with better properties. On the reverse, Alpine populations from the French Alps growing at low elevations have a slower growth, a denser wood with less heartwood and less strength. Used as a control, the hybrid larch origin (Larix x eurolepis) represents the best compromise for wood properties with the highest strength but an average wood density and one of the highest proportion of heartwood. These preliminary results must be confirmed from a larger set of provenances and completed with other major wood properties such as durability and shrinkage. 17 refs, 2 figs, 6 tabs
Intraspecific variability of European larch for wood properties: Preliminary results
Energy Technology Data Exchange (ETDEWEB)
Paques, L E; Rozenberg, P [Institut National de Recherches Agronomiques (INRA), 45 - Olivet (France). Station d` Amelioration des Arbres Forestiers
1996-12-31
Wood properties of several natural populations of European larch (Larix decidua Mill) were determined from samples collected in one replicate of the II. International IUFRO provenance experiment, planted in Brittany in 1959. According to provenances, proportion of heartwood ranges from 35 to 58% of basal area, basic density from 442 to 505 g/dm{sup 3} and Young modulus of elasticity from 8474 to 14522 MPa. Positive correlations between girth and heartwood proportion and between wood density and modulus of elasticity but negative correlations between ring width and both density and MOE have been found both at the individual and at the population levels. Variability between and within provenances is high for two major traits (proportion of heartwood and Young modulus of elasticity) for which a SW - NE gradient is shown. For wood density parameters including pilodyn, a greater homogeneity is observed. Besides a now largely recognized superiority for growth traits, Central European populations from the Sudetan Mountains and Central Poland would also produce wood with better properties. On the reverse, Alpine populations from the French Alps growing at low elevations have a slower growth, a denser wood with less heartwood and less strength. Used as a control, the hybrid larch origin (Larix x eurolepis) represents the best compromise for wood properties with the highest strength but an average wood density and one of the highest proportion of heartwood. These preliminary results must be confirmed from a larger set of provenances and completed with other major wood properties such as durability and shrinkage. 17 refs, 2 figs, 6 tabs
International Nuclear Information System (INIS)
Lee, Jeong-Min; Han, Young Min; Lee, Sang Yong; Kim, Chong Soo; Yang, Doo Hyun; Lee, Seung Ok
2001-01-01
Purpose: To evaluate the efficacy of the placement of covered metallic stents for palliation of gastrointestinal anastomotic strictures secondary to recurrent gastric cancer.Methods: Under fluoroscopic guidance, placement of one or two self-expandable covered metallic stents was attempted perorally in 11 patents (aged 48-76 years) with anastomotic stenoses due to recurrent gastric malignancies. The strictures involved both the afferent and efferent loops in three patients. All patients had poor peroral food intake with severe nausea and vomiting after ingestion. The technical and clinical success was evaluated.Results: Placement of the covered stent was technically successful in 13 of 15 (87%) attempts in ten patients. After the procedure, 9 of 11 (82%) patients overall were able to ingest at least a liquid diet and had markedly decreased incidence of vomiting. During the follow-up of 2-31 weeks (mean 8.5 weeks) there were no major complications.Conclusion: These preliminary results suggest that flexible, covered stents may provide effective palliation of malignant anastomotic stricture secondary to recurrent gastric cancer
Seismic Hazard Maps for the Maltese Archipelago: Preliminary Results
D'Amico, S.; Panzera, F.; Galea, P. M.
2013-12-01
The Maltese islands form an archipelago of three major islands lying in the Sicily channel at about 140 km south of Sicily and 300 km north of Libya. So far very few investigations have been carried out on seismicity around the Maltese islands and no maps of seismic hazard for the archipelago are available. Assessing the seismic hazard for the region is currently of prime interest for the near-future development of industrial and touristic facilities as well as for urban expansion. A culture of seismic risk awareness has never really been developed in the country, and the public perception is that the islands are relatively safe, and that any earthquake phenomena are mild and infrequent. However, the Archipelago has been struck by several moderate/large events. Although recent constructions of a certain structural and strategic importance have been built according to high engineering standards, the same probably cannot be said for all residential buildings, many higher than 3 storeys, which have mushroomed rapidly in recent years. Such buildings are mostly of unreinforced masonry, with heavy concrete floor slabs, which are known to be highly vulnerable to even moderate ground shaking. We can surely state that in this context planning and design should be based on available national hazard maps. Unfortunately, these kinds of maps are not available for the Maltese islands. In this paper we attempt to compute a first and preliminary probabilistic seismic hazard assessment of the Maltese islands in terms of Peak Ground Acceleration (PGA) and Spectral Acceleration (SA) at different periods. Seismic hazard has been computed using the Esteva-Cornell (1968) approach which is the most widely utilized probabilistic method. It is a zone-dependent approach: seismotectonic and geological data are used coupled with earthquake catalogues to identify seismogenic zones within which earthquakes occur at certain rates. Therefore the earthquake catalogues can be reduced to the
Self-potential time series analysis in a seismic area of the Southern Apennines: preliminary results
Directory of Open Access Journals (Sweden)
V. Tramutoli
1994-06-01
Full Text Available The self-potential time series recorded during the period May 1991 - August 1992 by an automatic station, located in a seismic area of Southern Apennines, is analyzed. We deal with the spectral and the statistical features of the electrotellurie precursors: they can play a major role in the approach to seismic prediction. The time-dynamics of the experimental time series is investigated, the cyclic components and the time trends are removed. In particular we consider the influence of external noise, related to anthropic activities and meteoclimatic parameters, and pick out the anomalies from the residual series. Finally we show the preliminary results of the correlation between the anomalies in the time patterns of self-potential data and the earthquakes which occurred in the area.
Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study.
Tregellas, Jason R; Smucny, Jason; Legget, Kristina T; Stevens, Karen E
2015-12-01
Although the ketogenic diet has shown promise in a pilot study and case report in schizophrenia, its effects in animal models of hypothesized disease mechanisms are unknown. This study examined effects of treatment with the ketogenic diet on hippocampal P20/N40 gating in DBA/2 mice, a translational endophenotype that mirrors inhibitory deficits in P50 sensory gating in schizophrenia patients. As expected, the diet increased blood ketone levels. Animals with the highest ketone levels showed the lowest P20/N40 gating ratios. These preliminary results suggest that the ketogenic diet may effectively target sensory gating deficits and is a promising area for additional research in schizophrenia. Published by Elsevier B.V.
International Nuclear Information System (INIS)
Schuermann, K.; Buecker, A.; Tacke, J.; Schmitz-Rode, T.; Guenther, R.W.; Jansen, M.
2002-01-01
Aim: To evaluate intra-arterial CT mesentericography (CTM) in the diagnostics of severe obscure overt intestinal bleeding in comparison with conventional mesentericography (MG) and surgery. Methods: In 8 patients (23 - 82 years, mean 59 years), CTM was performed via the catheter left in the superior mesenteric artery after MG to detect the source of bleeding. Early and late-phase spiral CT scans were acquired after administration of contrast medium. Active bleeding was considered to be present if extravasation of contrast medium into the bowel was found. The results of MG and CTM were compared with the results of surgery. Results: With MG active bleeding was found in one patient, with CTM in five patients. In three patients, both MG and CTM were negative. Six patients underwent surgery. Five cases of bleeding detected with CTM were confirmed by surgery. In one case, bleeding found with CTM was not confirmed by surgery. One patient underwent surgery although all imaging procedures were negative. The source of bleeding remained unknown. Surgically, the site of bleeding was located in the jejunum in 3 patients (jejunitis, jejunal ulcers, carcinoid), one patient had a diverticulum in the ascending colon. The colonic bleeding site was correctly localized with CTM, whereas the small bowel bleeding could only roughly be assigned to the proximal or distal jejunum or jejunoileal transition area. Conclusion: Preliminary results indicate that selective CTM is superior to MG in the evaluation of severe obscure overt intestinal bleeding. (orig.) [de
In situ vitrification: Preliminary results from the first large-scale radioactive test
International Nuclear Information System (INIS)
Buelt, J.L.; Westsik, J.H.
1988-02-01
The first large-scale radioactive test (LSRT) of In Situ Vitrification (ISV) has been completed. In Situ Vitrification is a process whereby joule heating immobilizes contaminated soil in place by converting it to a durable glass and crystalline waste form. The LSRT was conducted at an actual transuranic contaminated soil site on the Department of Energy's Hanford Site. The test had two objectives: (1) determine large-scale processing performance and (2) produce a waste form that can be fully evaluated as a potential technique for the final disposal of transuranic-contaminated soil sites at Hanford. This accomplishment has provided technical data to evaluate the ISV process for its potential in the final disposition of transuranic-contaminated soil sites at Hanford. Because of the test's successful completion, within a year technical data on the vitrified soil will be available to determine how well the process incorporates transuranics into the waste form and how well the form resists leaching of transuranics. Preliminary results available include retention of transuranics and other elements within the waste form during processing and the efficiency of the off-gas treatment system in removing contaminants from the gaseous effluents. 13 refs., 10 figs., 5 tabs
Cernavoda NPP impact study on terrestrial and aquatic biota. Preliminary results
International Nuclear Information System (INIS)
Bobric, Elena; Bucur, Cristina; Popescu, Ion; Simionov, Vasile; Titescu, Gheorghe; Varlam, Carmen
2010-01-01
Recently, the awareness of the vulnerability of the environment has increased and the need to protect it against industrial pollutants has been recognized. The concept of sustainable development, requires new and developing international policies for environmental protection. See 'Protection of the environment from the effects of ionizing radiation' IAEA-TECDOC-1091, International Atomic Energy Agency, Vienna. As it is recommended in 'Cernavoda Unit No. 2 NPP Environmental Impact Assessment CES-03702-IAD-006', it is Cernavoda NPP responsibility to conduct an Ecological Risk Assessment study, mainly to assess the impact of nuclear power plant operation on terrestrial and aquatic biota. Long records from normal operation of Cernavoda Unit 1, wind pattern, meteorological conditions, and source terms data were used to evaluate areas of interest for environmental impact, conducting to a circle of 20 km radius around mentioned nuclear objective. The screening campaign established tritium level (because Cernavoda NPP is a CANDU type reactor, and tritium is the most important radioisotope evacuated in the environment) in air, water, soil and vegetation, focusing the interest area on particular ecosystem. Using these primary data it was evaluated which are the monitored ecological receptors and which are the measurement endpoints.This paper presents the Ecological Risk Assessment at Cernavoda NPP technical requirements, and the preliminary results of evaluating criteria for representative ecosystem components at Cernavoda NPP. (authors)
Searching for moving objects in HSC-SSP: Pipeline and preliminary results
Chen, Ying-Tung; Lin, Hsing-Wen; Alexandersen, Mike; Lehner, Matthew J.; Wang, Shiang-Yu; Wang, Jen-Hung; Yoshida, Fumi; Komiyama, Yutaka; Miyazaki, Satoshi
2018-01-01
The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is currently the deepest wide-field survey in progress. The 8.2 m aperture of the Subaru telescope is very powerful in detecting faint/small moving objects, including near-Earth objects, asteroids, centaurs and Tran-Neptunian objects (TNOs). However, the cadence and dithering pattern of the HSC-SSP are not designed for detecting moving objects, making it difficult to do so systematically. In this paper, we introduce a new pipeline for detecting moving objects (specifically TNOs) in a non-dedicated survey. The HSC-SSP catalogs are sliced into HEALPix partitions. Then, the stationary detections and false positives are removed with a machine-learning algorithm to produce a list of moving object candidates. An orbit linking algorithm and visual inspections are executed to generate the final list of detected TNOs. The preliminary results of a search for TNOs using this new pipeline on data from the first HSC-SSP data release (2014 March to 2015 November) present 231 TNO/Centaurs candidates. The bright candidates with Hr 5 show that the best-fitting slope of a single power law to absolute magnitude distribution is 0.77. The g - r color distribution of hot HSC-SSP TNOs indicates a bluer peak at g - r = 0.9, which is consistent with the bluer peak of the bimodal color distribution in literature.
Directory of Open Access Journals (Sweden)
M Zamani
2013-01-01
Full Text Available Introduction: Transient global ischemia induces selective, delayed neuronal death of pyramidal neurons in the hippocampal CA1. Oxidative Stress is considered to be involved in a number of human diseases including ischemia. Preliminary studies confirmed reduction of cell death in brain following treatment with antioxidants. Aim: According to this finding, we study the relationship between consumption of olive oil on cell death and memory disorder in brain ischemia. We studied the protective effect of olive oil against ischemia-reperfusion. Material and Methods: Experimental design includes three groups: Intact (n = 8, ischemic control (n = 8 and treatment groups with olive oil (n = 8. The mice treated with olive oil as pre-treatment for a week. Then, ischemia induced by common carotid artery ligation and following the reduction of inflammation [a week after ischemia], the mice post-treated with olive oil. Nissl staining applied for counting necrotic cells in hippocampus CA1. Tunnel kit was used to quantify apoptotic cell death while to short term memory scale, we apply y-maze and shuttle box tests and for detection the rate of apoptotic and treated cell, we used western blotting test for bax and bcl2 proteins. Results: High rate of apoptosis was seen in ischemic group that significantly associated with short-term memory loss. Cell death was significantly lower when mice treated with olive oil. The memory test results were adjusted with cell death results and bax and bcl2 expression in all groups′ comparison. Ischemia for 15 min induced cell death in hippocampus with more potent effect on CA1. Conclusion: Olive oil intake significantly reduced cell death and decreased memory loss.
Directory of Open Access Journals (Sweden)
Yi Teng Shih
2015-11-01
Full Text Available This paper presents the results of a preliminary protocol study of the cognitive behaviour of architectural designers during the design process. The aim is to better understand the similarities and differences in cognitive behaviour using Sequential Mixed Media (SMM and Alternative Mixed Media (AMM approaches, and how switching between media may impact on design processes. Two participants with at least one-year’s professional design experience and a Bachelor of Design degree, and competence in both sketching and computer-aid design (CAD modelling participated in the study. Video recordings of participants working on different projects were coded using the Function-Behaviour-Structure (FBS coding scheme. Participants were also interviewed and their explanations about their switching behaviours were categorised into three types: S→C, S/C↹R and C→S. Preliminary results indicate that switching between media may influence how designers identify problems and develop solutions. In particular, two design issues were identified. These relate to the FBS coding scheme, where structure (S and behaviour derived from structure (Bs, change to documentation (D after switching from sketching to CAD modelling (S→C. These switches make it possible for designers to integrate both approaches into one design medium and facilitate their design processes in AMM design environments.
Directory of Open Access Journals (Sweden)
Mahdi Saadati
2014-12-01
Full Text Available Background & objectives : Infertility is a global problem affecting millions of men and women in developed and developing countries. In this regard, in-vitro fertilization (IVF plays an important role in improving the quality of life in infertile patients. However, studies have shown that the implantation failure in IVF is the main challenge of this procedure. Melatonin can increase the survival rate of embryos and IVF success rate through eliminating free radicals and removing reactive oxygen species. So, this study is conducted to investigate the effects of different concentrations of melatonin on the rate of newborns of mice following transfer oftwo-cell embryos . Methods : In this study, female mice with average age of six to eight weeks were superovulated by administering pregnant mares serum gonadotropin (PMSG intraperitoneally (7.5 IU. ip, and followed after 48h by human chorionic gonadotropin (hCG (7.5 IU. ip. Two-cell mouse embryos were obtained from female mice oviduct after 48 h. The embryos transferred bilaterally into pseudopregnant mice of the same strain through surgical procedure and 8-14 embryos were transferred to each tube. The study included 4 treatment groups and one control group (6 mice in each group. The treatment groups were exposed to subcutaneous injection of concentrations of 100 µm , 10 µm , 1 µm and 100 nm of melatonin. After the cesarean on 18th day of pregnancy, the percentage of live births was assessed. The outcomes of the live birth rate were assessed using the chi-square test and statistical analyses were carried out using SPSS version 16.0. Percentage of live birth was calculated and compared with the control group. Results: A total of 701 two-cell mouse embryos were transferred into one control group and four experimental groups. The number and percentage of live births at concentrations of 100 µm and 10 µm of melatonin and the control groups were 21 (15.55%, 13 (9.15% and 9 (6
Chronic Co-species Housing Mice and Rats Increased the Competitiveness of Male Mice.
Liu, Ying-Juan; Li, Lai-Fu; Zhang, Yao-Hua; Guo, Hui-Fen; Xia, Min; Zhang, Meng-Wei; Jing, Xiao-Yuan; Zhang, Jing-Hua; Zhang, Jian-Xu
2017-03-01
Rats are predators of mice in nature. Nevertheless, it is a common practice to house mice and rats in a same room in some laboratories. In this study, we investigated the behavioral and physiological responsively of mice in long-term co-species housing conditions. Twenty-four male mice were randomly assigned to their original raising room (control) or a rat room (co-species-housed) for more than 6 weeks. In the open-field and light-dark box tests, the behaviors of the co-species-housed mice and controls were not different. In a 2-choice test of paired urine odors [rabbit urine (as a novel odor) vs. rat urine, cat urine (as a natural predator-scent) vs. rabbit urine, and cat urine vs. rat urine], the co-species-housed mice were more ready to investigate the rat urine odor compared with the controls and may have adapted to it. In an encounter test, the rat-room-exposed mice exhibited increased aggression levels, and their urines were more attractive to females. Correspondingly, the levels of major urinary proteins were increased in the co-species-housed mouse urine, along with some volatile pheromones. The serum testosterone levels were also enhanced in the co-species-housed mice, whereas the corticosterone levels were not different. The norepinephrine, dopamine, and 5-HT levels in the right hippocampus and striatum were not different between the 2. Our findings indicate that chronic co-species housing results in adaptation in male mice; furthermore, it appears that long-term rat-odor stimuli enhance the competitiveness of mice, which suggests that appropriate predator-odor stimuli may be important to the fitness of prey animals. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
International Nuclear Information System (INIS)
Zhang Gejun; Dai Ruping; Liu Yanling; Jiang Shiliang; Zeng Zheng; Huang Lianjun; Xie Ruolan
2001-01-01
Objective: To evaluate the efficiency and preliminary results of transcatheter closure of secundum atrial septal defect (ASD) with CardioSEAL septal occluder. Methods: There were 12 patients in this study. Trans-esophageal echocardiography (TEE) before the interventions confirmed the ASDs with a mean diameter of *13.14 +- 3.48) mm (ranging from 8 to 20 mm). There were 11 isolated ASDs and 1 multi-defects ASD in the group. Each ASD was occluded with CardioSEAL septal occluder through the percutaneous procedure. The closure procedure was guided by fluoroscopy and trans-esophageal echocardiography. The TEE was done immediately after the procedure to find whether there was residual shunt. Trans-thoracic-echocardiography (TTE), ECG, and X-ray examination were done 24 hours, 1 month, 3 months, and 1 year after the procedures as follow-up to evaluate the efficiency. Results: The placements of the occluders were successful in 11 cases. There were no mortality and no emergent surgery during the procedures. TEE confirmed that there were trivial and small residual shunts in 3 cases immediately after the procedures. TTE confirmed small residual shunts in 2 cases 24 hour after the procedures, and in 1 case 1 month, 3 month, and 1 year after the procedures. Conclusion: Transcatheter closure of secundum ASD with CardioSEAL septal occluder was an efficient nonsurgical method. It could be the method of choice in treating the ASDs with special anatomic variations. It had a high successful rate of device placement and satisfied preliminary results, but the long-term follow-up was needed
Directory of Open Access Journals (Sweden)
K. Goyal
2010-01-01
Full Text Available Purpose. Stereotactic body radiation therapy (SBRT has emerged as a treatment option for local tumor control of primary and secondary malignancies of the liver. We report on our updated experience with SBRT in patients with non-resectable tumors of the liver. Methods. Our first 17 consecutive patients (mean age 58.1 years receiving SBRT for HCC (=6, IHC (=3, and LM (=8 are presented. Mean radiation dose was 34Gy delivered over 1–3 fractions. Results. Treated patients had a mean decrease in maximum pretreatment tumor diameter from 6.9±4.6 cm to 5.0±2.1 cm at three months after treatment (<.05. The mean total tumor volume reduction was 44% at six months (<.05. 82% of all patients (14/17 achieved local control with a median follow-up of 8 months. 100% of patients with HCC (=6 achieved local control. Patients with surgically placed fiducial markers had no complications related to marker placement. Conclusion. Our preliminary results showed that SBRT is a safe and effective local treatment modality in selected patients with liver malignancies with minimal adverse events. Further studies are needed to define its role in the management of these malignancies.
Application of a PCR method for the diagnosis of ulcerative enteritis: preliminary results
Directory of Open Access Journals (Sweden)
Fabrizio Agnoletti
2010-01-01
Full Text Available Ulcerative enteritis or “quail disease” is an acute clostridial infection of young birds reported in many avian species, chicken and turkey included. Clostridium colinum is the causative agent of ulcerative enteritis and because of the difficulties bound to the isolation and identification of this bacterium by means of classic bacteriological techniques, its detection appears very hard and the prevalence of this disease could be underestimated. To investigate the diffusion of C. colinum in enteric disease of birds, a recently developed PCR protocol was applied to 42 cultural broths previously inoculated with organs and intestinal samples collected from diseased subjects. PCR-positive broths were cultivated to attempt the isolation of C. colinum. Samples collected from positive birds were subjected to histological examinations. 4 birds (3 broilers chickens and 1 pigeon resulted PCR-positive and, in one case, C. colinum was isolated. Gross and histological lesions of positive birds were compatible with those described in other ulcerative enteritis outbreaks. These preliminary results demonstrates that C. colinum is sporadically implicated in enteric diseases of broiler chickens (14.2%. In addition, the PCR assay proved to be an useful and reliable instrument to support the diagnosis of ulcerative enteritis and to facilitate the isolation of C. colinum.
Preliminary results of a national quality audit programme in radiotherapy services in Cuba
International Nuclear Information System (INIS)
Dominguez Hung, L.; Larrinaga Cortina, E.F.; Campa Menendez, R.; Morales Lopez, J.L.; Garcia Yip, A.F.
2001-01-01
The current state of radiotherapy in Cuba has allowed to pass to a superior stage in the process of quality assurance, the establishment of a National Quality Audit Program (PNAC). The National Control Center for Medical Devices, as national regulator entity for the control and supervision of the medical devices of the National Health System, is responsible for the implementation of this program. This paper presents the preliminary results of the execution of the PNAC in teletherapy services with isotopic units of 60 Co. The audits were carried out according to the methodology settled down in the normalized procedure of operation of the PNAC. The physical aspects related with the treatment were audited, such as: the installation and unit's safety, mechanical and dosimetric aspects of the treatment unit and organizational aspects of the institution quality assurance program. Also carried out, in the clinical aspect, verifications of cases type planned by the qualified personnel of the service. The results corresponding to the determination of the reference dose for each institution were compared with those obtained in a postal audit with the International Atomic Energy Agency. These first audits allowed to evaluate the performance of the institutions' program of quality assurance and a feedback for the setting about to the PNAC. (author)
Preliminary results of a national quality audit programme in radiotherapy services in Cuba
Energy Technology Data Exchange (ETDEWEB)
Dominguez Hung, L; Larrinaga Cortina, E F [Centro de Control Estatal de Equipos Medicos, Havana (Cuba); Campa Menendez, R [Centro de Proteccion e Higiene de las Radiaciones, Havana (Cuba); Morales Lopez, J L; Garcia Yip, A F [Instituto Nacional de Oncologia y Radiobiologia, Havana (Cuba)
2001-03-01
The current state of radiotherapy in Cuba has allowed to pass to a superior stage in the process of quality assurance, the establishment of a National Quality Audit Program (PNAC). The National Control Center for Medical Devices, as national regulator entity for the control and supervision of the medical devices of the National Health System, is responsible for the implementation of this program. This paper presents the preliminary results of the execution of the PNAC in teletherapy services with isotopic units of {sup 60}Co. The audits were carried out according to the methodology settled down in the normalized procedure of operation of the PNAC. The physical aspects related with the treatment were audited, such as: the installation and unit's safety, mechanical and dosimetric aspects of the treatment unit and organizational aspects of the institution quality assurance program. Also carried out, in the clinical aspect, verifications of cases type planned by the qualified personnel of the service. The results corresponding to the determination of the reference dose for each institution were compared with those obtained in a postal audit with the International Atomic Energy Agency. These first audits allowed to evaluate the performance of the institutions' program of quality assurance and a feedback for the setting about to the PNAC. (author)
Radioiodine therapy in non toxic multi nodular goitre, preliminary results
International Nuclear Information System (INIS)
Chiti, A.; Travaini, L.L.; Tadayyon, S.; Vannucchi, G.; Fugazzola, L.; Beck-Peccoz, P.
2002-01-01
Aim: Aim of our study was to assess the efficacy of 131 I therapy in patients (pts) affected by non toxic multinodular goitre (NTMG). NTMG is a thyroid disease with a high prevalence, especially in low-iodine intake regions. Treatment of NTMG often requires surgery. However, thyroidectomy may be risky in some patients and radioiodine therapy could be an alternative treatment to reduce thyroid volume. We also evaluated if lithium administration can improve the efficacy of radioiodine treatment in this pts. Material and Methods: We enrolled 39 pts (8 males, 31 females; mean age 59 y, range 40-79 y) affected by NTMG. Mean thyroid volume (TV) at ultrasound was of 46.8 ml (range 18.5-87.3). Pts were randomised in 2 groups. Group 1: iodine therapy + lithium therapy 900 mg/die for 6 days; Group 2: iodine therapy alone. We also define 3 clusters of pts by TV. A:15-30 ml; B:31-40 ml; C: > 40 ml. The 131 I activity (MBq) was calculated as follows: [4.44 (MBq) x 100/24 hours uptake (%)] x TV. All patients are evaluated for thyroid function and TV at 3, 6, 12, 18 and 24 months after treatment, since we postulate that major reduction in thyroid volume will occur 1 year after 131 I therapy. Results: Up to now 16 pts were treated with 131 I (mean activity: 512 MBq) and no side effects from 131 I and lithium therapy were reported. Four out of 5 pts evaluated at 3 months (2 of group 1 and 3 of group 2) had a reduction in TV (mean value: 8.8 ml). Five out of 10 pts had sub-clinical hyperthyroidism at 1 week, likely as a consequence of thyroid tissue destruction. Conclusion: Our preliminary results suggest the safety and effectiveness of 131 I treatment in NTMG. We expect to clarify the role of lithium administration in improving 131 I efficacy. This therapy could have a future role in patients with NTMG that can't be submitted to surgery
Pierce, Angela N.; Zhang, Zhen; Fuentes, Isabella M.; Wang, Ruipeng; Ryals, Janelle M.; Christianson, Julie A.
2015-01-01
Abstract Experiencing early life stress or injury increases a woman's likelihood of developing vulvodynia and concomitant dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. To investigate the outcome of neonatal vaginal irritation (NVI), female mouse pups were administered intravaginal zymosan on postnatal days 8 and 10 and were assessed as adults for vaginal hypersensitivity by measuring the visceromotor response to vaginal balloon distension (VBD). Western blotting and calcium imaging were performed to measure transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) in the vagina and innervating primary sensory neurons. Serum corticosterone (CORT), mast cell degranulation, and corticotropin-releasing factor receptor 1 (CRF1) expression were measured as indicators of peripheral HPA axis activation. Colorectal and hind paw sensitivity were measured to determine cross-sensitization resulting from NVI. Adult NVI mice had significantly larger visceromotor response during VBD than naive mice. TRPA1 protein expression was significantly elevated in the vagina, and calcium transients evoked by mustard oil (TRPA1 ligand) or capsaicin (TRPV1 ligand) were significantly decreased in dorsal root ganglion from NVI mice, despite displaying increased depolarization-evoked calcium transients. Serum CORT, vaginal mast cell degranulation, and CRF1 protein expression were all significantly increased in NVI mice, as were colorectal and hind paw mechanical and thermal sensitivity. Neonatal treatment with a CRF1 antagonist, NBI 35965, immediately before zymosan administration largely attenuated many of the effects of NVI. These results suggest that NVI produces chronic hypersensitivity of the vagina, as well as of adjacent visceral and distant somatic structures, driven in part by increased HPA axis activation. PMID:26098441
International Nuclear Information System (INIS)
Yamada, T.
1978-01-01
Cooling ponds receive large amounts of waste heat from industrial sources and release the heat to the atmosphere. These large area sources of warm and moist air may have significant inadvertent effects. This paper is a preliminary step in the development of a method for estimating the perturbations in the atmosphere produced by a cooling pond. A three-dimensional numerical model based on turbulence second-moment closure equations and Gaussian cloud relations has been developed. A simplified version of the model, in which only turbulent energy and length-scale equations are solved prognostically, is used. Numerical simulations are conducted using as boundary conditions the data from a cooling pond study conducted in northern Illinois during the winter of 1976-1977. Preliminary analyses of these simulations indicate that formation of clouds over a cooling pond is sensitive to the moisture content in the ambient atmosphere
RHF RELAP5 model and preliminary loss-of-offsite-power simulation results for LEU conversion
Energy Technology Data Exchange (ETDEWEB)
Licht, J. R. [Argonne National Laboratory (ANL), Argonne, IL (United States). Nuclear Engineering Div.; Bergeron, A. [Argonne National Laboratory (ANL), Argonne, IL (United States). Nuclear Engineering Div.; Dionne, B. [Argonne National Laboratory (ANL), Argonne, IL (United States). Nuclear Engineering Div.; Thomas, F. [Institut Laue-Langevin (ILL), Grenoble (Switzerland). RHF Reactor Dept.
2014-08-01
The purpose of this document is to describe the current state of the RELAP5 model for the Institut Laue-Langevin High Flux Reactor (RHF) located in Grenoble, France, and provide an update to the key information required to complete, for example, simulations for a loss of offsite power (LOOP) accident. A previous status report identified a list of 22 items to be resolved in order to complete the RELAP5 model. Most of these items have been resolved by ANL and the RHF team. Enough information was available to perform preliminary safety analyses and define the key items that are still required. Section 2 of this document describes the RELAP5 model of RHF. The final part of this section briefly summarizes previous model issues and resolutions. Section 3 of this document describes preliminary LOOP simulations for both HEU and LEU fuel at beginning of cycle conditions.
Low-pressure injection molding of alumina ceramics using a carnauba wax binder: preliminary results
Energy Technology Data Exchange (ETDEWEB)
Quevedo Nogueira, R.E.F.; Bezerra, A.C.; Santos, F.C. dos [Dept. de Engenharia Mecanica, Centro de Tecnologia-UFC, Fortaleza, CE (Brazil); Sousa, M.R. de; Acchar, W. [Dept. de Engenharia Mecanica, Univ. Federal do Rio Grande do Norte, UFRN-Campus Univ., Natal, RN (Brazil)
2001-07-01
Carnauba wax, a natural product from Northeastern Brazil, has found application in the processing of ceramics. However, the use of pure carnauba wax is not recommended due to its narrow melting range and poor mechanical properties. In the present work carnauba wax based organic vehicles with the addition of low-density polyethylene and stearic acid were developed for use in the low-pressure injection molding of alumina ceramics. Viscosimetric testing was employed for the determination of optimal composition of the organic vehicle. The optimal content of ceramic powder in the mixture was also determined. All the materials used are easily available in the Brazilian market. A simple ceramic part was injected at low pressures (0.6 MPa) using a semi-automatic injection molding machine. For this purpose a double cavity mold was designed and built. Preliminary results demonstrate the technical viability of the process using the organic vehicle developed. (orig.)
Directory of Open Access Journals (Sweden)
L. Peña-Chocarro
2013-04-01
Full Text Available This contribution focuses on the preliminary results of the AGRIWESTMED project which focuses on the archaeobotanical analyses of early Neolithic sites in the western Mediterranean region (both in Iberia and in northern Morocco. A large number of sites has been studied producing an interesting dataset of plant remains which places the earliest examples of domesticated plants in the second half of the 6th millennium cal BC. Plant diversity is high as it is shown by the large number of species represented: hulled and naked wheats, barley, peas, fava beans, vetches, lentils and grass peas. To more crops, poppy and flax, are also part of the first agricultural crops of the area. Although agriculture seems to occupy a first place in the production of food, gathering is well represented in the Moroccan sites where a large number of species has been identified.
International Nuclear Information System (INIS)
Yang Hailiang; Qiu Aici; Zhang Jiasheng; He Xiaoping; Sun Jianfeng; Peng Jianchang; Tang Junping; Ren Shuqing; Ouyang Xiaoping; Zhang Guoguang; Huang Jianjun; Yang Li; Wang Haiyang; Li Jingya; Li Hongyu
2004-01-01
Preliminary results for the generation and application of the high power ion beam (HPIB) on the FLASH II accelerator are reported. The structure and principle of the pinch reflex ion beam diode are introduced. The equation of parapotential flow is corrected for the reduction of diode A-K gap due to the motion of cathode and anode plasma. The HPIB peak current of ∼160 kA is obtained with a peak energy of ∼500 keV. Experimental investigations of generating 6-7 MeV quasi-monoenergetic pulsed γ-rays with high power ion (proton) beams striking 19 F target are presented. In addition, the results of the thermal-mechanical effects on the material irradiated with HPIB, which are applied to the simulation of 1 keV black body radiation x-rays, are also discussed
In vivo radioprotection by alpha-TMG: preliminary studies.
Satyamitra, M; Devi, P U; Murase, H; Kagiya, V T
2001-08-08
alpha-TMG is a novel water-soluble derivative of Vitamin E that has shown excellent antioxidant activity. The parent compound has demonstrated protection against radiation induced chromosomal damage in vivo. Hence, the preliminary experiments to determine the radioprotective activity of alpha-TMG were carried out in adult Swiss albino mice. Acute toxicity of the drug was studied taking 24h, 72 h and 30 day mortality after a single intraperitoneal injection of 500-2000 mg/kg body weight of the drug. The drug LD(50) for 24h and 72 h/30 day survival were found to be 1120 and 1000 mg/kg body weight, respectively. The optimum time of drug administration and drug dose-dependent effect on in vivo radiation protection of bone marrow chromosomes was studied in mice. Injection of 600 mg/kg of the drug 15 min before or within 5, 15 or 30min after 3Gy whole body gamma radiation resulted in a significant decrease in the aberrant metaphases percent at 24h post-irradiation; the maximum effect was seen when the drug was given immediately after irradiation. Injection of 200-800 mg/kg TMG within 5 min of irradiation with 3 Gy produced a significant dose-dependent reduction in the radiation induced percent aberrant metaphases and in the frequency of micronucleated erythrocytes at 24h after exposure, with a corresponding decrease in the different types of aberrations. The optimum dose for protection without drug toxicity was 600 mg/kg body weight. At this dose, TMG produced 70 and >60% reduction in the radiation induced percent aberrant metaphases and micronucleated erythrocytes, respectively. The high water solubility and effectiveness when administered post-irradiation favor TMG as a likely candidate for protection in case of accidental exposures.
International Nuclear Information System (INIS)
Mariano, Davi B.; Figueiredo, Ana Maria G.; Semmler, Renato
2009-01-01
The present paper presents the preliminary results obtained in the implementation of the k 0 standardization method at the Neutron Activation Laboratory (LAN) at IPEN, Sao Paulo, Brazil, using the program k 0 -IAEA, provided by The International Atomic Energy Agency (IAEA). This method is an important alternative for the comparative neutron activation analysis, which has been used for several years at LAN-IPEN. This quasiabsolute standardization method presents a great advantage with relation to the comparative method, since it does not require the preparation of accurate individual standards for each analysed element, which is very laborious and time-consuming. The k 0 method allows the determination of almost all elements whose gammaray peaks are present in the gamma spectrum. The analysis of gamma-ray spectra and the calculation of concentration are performed by the k 0 software, thus the analysis time is shortened: the time spent to calculate, for instance, the concentration of 25 elements in 10 samples takes about 5 minutes.The efficiency curve of one of the gamma-ray spectrometers used at LAN was determined by measuring calibrated radioactive sources at the usually utilised counting geometries. The parameters α and f were determined by irradiating a Certified Nuclear Reference Material IRMM-530R Al-0,1% Au alloys and high purity zirconium comparators at the IEA-R1 nuclear reactor of IPEN. In order to evaluate the efficiency of the methodology, the geological reference material basalt JB-1 (GSJ) was analysed. The preliminary results obtained showed promising results in spite of some discrepancies of the data in comparison to certified values. These preliminary results indicate that some improvements in the parameters required for the use of the k 0 -IAEA software should be made so that the k 0 - NAA software can be completely successful. (author)
Masternak, Michal M; Darcy, Justin; Victoria, Berta; Bartke, Andrzej
2018-01-01
Dwarf mice have been studied for many decades, however, the focus of these studies shifted in 1996 when it was shown by Brown-Borg and her coworkers that Ames dwarf (Prop1 df ) mice are exceptionally long-lived. Since then, Snell dwarf (Pit1 dw ) and growth hormone receptor knockout (GHR-KO, a.k.a. Laron dwarf) mice were also shown to be exceptionally long-lived, presumably due to their growth hormone (GH)-deficiency or -resistance, respectively. What is of equal importance in these dwarf mice is their extended health span, that is, these animals have a longer period of life lived free of frailty and age-related diseases. This review article focuses on recent studies conducted in these dwarf mice, which concerned brown and white adipose tissue biology, microRNA (miRNA) profiling, as well as early-life dietary and hormonal interventions. Results of these studies identify novel mechanisms linking reduced GH action with extensions of both life span and health span. Copyright © 2017. Published by Elsevier Inc.
2013-01-22
... DEPARTMENT OF COMMERCE International Trade Administration [A-351-825] Stainless Steel Bar From... steel bar (SSB) from Brazil. The period of review (POR) is February 1, 2011, through January 31, 2012... Review: Stainless Steel Bar from Brazil'' dated concurrently with this notice (``Preliminary Decision...
Spinel dissolution via addition of glass forming chemicals. Results of preliminary experiments
Energy Technology Data Exchange (ETDEWEB)
Fox, K. M. [Savannah River Site (SRS), Aiken, SC (United States); Johnson, F. C. [Savannah River Site (SRS), Aiken, SC (United States)
2015-11-01
Increased loading of high level waste in glass can lead to crystallization within the glass. Some crystalline species, such as spinel, have no practical impact on the chemical durability of the glass, and therefore may be acceptable from both a processing and a product performance standpoint. In order to operate a melter with a controlled amount of crystallization, options must be developed for remediating an unacceptable accumulation of crystals. This report describes preliminary experiments designed to evaluate the ability to dissolve spinel crystals in simulated waste glass melts via the addition of glass forming chemicals (GFCs).
Upper crustal structure beneath East Java from ambient noise tomography: A preliminary result
International Nuclear Information System (INIS)
Martha, Agustya Adi; Widiyantoro, Sri; Cummins, Phil; Saygin, Erdinc; Masturyono
2015-01-01
East Java has a fairly complex geological structure. Physiographically East Java can be divided into three zones, i.e. the Southern Mountains zone in the southern part, the Kendeng zone in the middle part, and the Rembang zone in the northern part. Most of the seismic hazards in this region are due to processes in the upper crust. In this study, the Ambient Noise Tomography (ANT) method is used to image the upper crustal structure beneath East Java. We have used seismic waveform data recorded by 8Meteorological, Climatological and Geophysical Agency (BMKG) stationary seismographic stations and 16 portable seismographs installed for 2 to 8 weeks. The data were processed to obtain waveforms fromnoise cross-correlation between pairs of seismographic stations. Our preliminary results indicate that the Kendeng zone, an area of low gravity anomaly, is associated with a low velocity zone. On the other hand, the southern mountain range, which has a high gravity anomaly, is related to a high velocity anomaly as shown by our tomographic images
Upper crustal structure beneath East Java from ambient noise tomography: A preliminary result
Energy Technology Data Exchange (ETDEWEB)
Martha, Agustya Adi [Meteorological, Climatological and Geophysical Agency, Jakarta (Indonesia); Graduate Research on Earthquakes and Active Tectonics, Institut Teknologi Bandung, Bandung (Indonesia); Widiyantoro, Sri [Global Geophysics Group, Institut Teknologi Bandung, Bandung (Indonesia); Center for Disaster Mitigation, Institut Teknologi Bandung, Bandung (Indonesia); Cummins, Phil; Saygin, Erdinc [Research School of Earth Sciences, Australian National University, Canberra (Australia); Masturyono [Meteorological, Climatological and Geophysical Agency, Jakarta (Indonesia)
2015-04-24
East Java has a fairly complex geological structure. Physiographically East Java can be divided into three zones, i.e. the Southern Mountains zone in the southern part, the Kendeng zone in the middle part, and the Rembang zone in the northern part. Most of the seismic hazards in this region are due to processes in the upper crust. In this study, the Ambient Noise Tomography (ANT) method is used to image the upper crustal structure beneath East Java. We have used seismic waveform data recorded by 8Meteorological, Climatological and Geophysical Agency (BMKG) stationary seismographic stations and 16 portable seismographs installed for 2 to 8 weeks. The data were processed to obtain waveforms fromnoise cross-correlation between pairs of seismographic stations. Our preliminary results indicate that the Kendeng zone, an area of low gravity anomaly, is associated with a low velocity zone. On the other hand, the southern mountain range, which has a high gravity anomaly, is related to a high velocity anomaly as shown by our tomographic images.
Preliminary clinical results from the EORTC 11961 trial at the petten irradiation facility
International Nuclear Information System (INIS)
Sauerwein, W.; Hideghety, K.; Vries, M.J. de
2000-01-01
Based on the pre-clinical work of the European Collaboration on Boron Neutron Capture Therapy a study protocol was prepared in 1995 to initiate Boron Neutron Capture Therapy (BNCT) in patients at the High Flux Reactor (HFR) in Petten. Bio-distribution and pharmacokinetics data of the boron drug Na 2 B 12 H 11 SH (BSH) as well as the radiobiological effects of BNCT with BSH in healthy brain tissue of dogs were considered in designing the strategy for this clinical Phase I trial. The primary goal of the radiation dose escalation study is the investigation of possible adverse events due to BNCT; i.e. to establish the dose limiting toxicity and the maximal tolerated radiation dose. The treatment is delivered in 4 fractions at a defined average boron concentration in blood. After an observation period of at least 6 months, the dose is increased by 10% for the next cohort. The preliminary results of the first cohort are presented here. The evaluated dose level can be considered to be safe. (author)
Preliminary results of robotic colorectal surgery at the National Cancer Institute, Cairo University
International Nuclear Information System (INIS)
Zaghloul, A.S.; Mahmoud, A.M.
2016-01-01
Background: The available literature on minimally invasive colorectal cancer demonstrates that laparoscopic approach is feasible and associated with better short term outcomes than open surgery while maintaining equivalent oncologic safety. Reports have shown that robotic surgery may overcome some of the pitfalls of laparoscopic intervention. Objective of the work: To evaluate early results of robotic colorectal surgery, in a cohort of Egyptian patients, regarding operative time, operative and early post-operative complications, hospital stay and pathological results. Patients and methods: A case series study which was carried out in surgical department at National Cancer Institute, Cairo University. Ten Egyptian cases of colorectal cancer (age ranged from 30 to 67, 5 males and 5 females) were recruited from the period of April 2013 to April 2014. Robotic surgery was performed to all cases. Results: Three patients had low anterior resection, three anterior resection, one total proctectomy, one abdominoperineal resection, one left hemicolectomy and one colostomy. The study reported no mortalities and two morbidities. The mean operative time was 333 min. The conversion to open was done in only one patient. A total mesorectal excision with negative circumferential margin was accomplished in all patients, distal margin was positive in one patient. Mean lymph nodes removed was 10.7. Mean hospital stay was 7.4 days. Conclusion: To the best of our knowledge, this is the first study reporting the outcomes of robotic colorectal cancer intervention in Egyptian patients. Our preliminary results suggest that robotic- assisted surgery for colorectal cancer can be carried out safely and according to oncological principles
Highland, Lynn M.
2003-01-01
The February 28, 2001, Nisqually, Washington, earthquake (Mw = 6.8) damaged an area of the northwestern United States that previously experienced two major historical earthquakes, in 1949 and in 1965. Preliminary estimates of direct monetary losses from damage due to earthquake-induced landslides is approximately $34.3 million. However, this figure does not include costs from damages to the elevated portion of the Alaskan Way Viaduct, a major highway through downtown Seattle, Washington that will be repaired or rebuilt, depending on the future decision of local and state authorities. There is much debate as to the cause of the damage to this viaduct with evaluations of cause ranging from earthquake shaking and liquefaction to lateral spreading to a combination of these effects. If the viaduct is included in the costs, the losses increase to $500+ million (if it is repaired) or to more than $1+ billion (if it is replaced). Preliminary estimate of losses due to all causes of earthquake damage is approximately $2 billion, which includes temporary repairs to the Alaskan Way Viaduct. These preliminary dollar figures will no doubt increase when plans and decisions regarding the Viaduct are completed.
International Nuclear Information System (INIS)
Schmitt, G.; Schaefer, U.W.; Nowrousian, M.R.; Oehl, S.
1979-01-01
Preliminary results of bone marrow transplantation of 8 patients are presented with particular reference to the irradiation technique. 5 patients died 0.5 to 8 months after transplantation. 3 patients are alive and in good condition 2 to 15 months after transplantation
Solar collectors and heat pump: Market review and preliminary simulation results
International Nuclear Information System (INIS)
Tepe, Rainer; Roennelid, Mats
2002-01-01
Heating systems that combine solar collectors and a heat pump available on the market in Sweden have been studied. A majority of the systems found combine the solar collectors with a ground source heat pump. The technology for combining the collectors and the heat pump does however vary considerably. In the most simple systems, the collectors heat the return water from the heat pump, i.e. the collectors are used for raising the temperature in the boreholes for the heat pump. In the advanced systems, the solar heat is used for tap water, space heating and for raising the temperature of the heat pump's evaporator. There exist only very few comparative evaluations of the contributions from solar collectors in heat pump systems, and there is a need for finding the potential for this technique. In the present study, results are reported from preliminary simulations of solar collectors and ground source heat pumps installed in one-family houses. Simulations are made for two heating loads: 8,650 and 16,500 kWh/year resp., and a hot water load of 3,000 kWh/year. The study shows that: the temperature of the borehole decreases when solar collectors are not used (about 1.2 deg C in three years): 8 m 2 glazed solar collectors used for hot water production can reduce the electricity consumption with up to 13%, with best results in the house with low heating load: 50 m 2 unglazed solar collectors coupled to the evaporator or the borehole can give reductions of up to 14%, largest reduction in the house with high heating load, where the heat extraction from the borehole is large: the unglazed collectors have the highest economic potential, and can be cost effective for houses with high heating load: the simulations do not include a thorough system optimization, better results can be expected from continued optimization work
PRELIMINARY RESULTS OF BOWL TRAPPING BEES (HYMENOPTERA, APOIDEA IN A SOUTHERN BRAZIL FOREST FRAGMENT
Directory of Open Access Journals (Sweden)
Rodrigo B. Gonçalves
2013-05-01
Full Text Available In recent years bowl traps have gained attention as a useful method for sampling bees and are now commonly used across the world for this purpose. However, specific questions about the method itself have not yet been tested on different regions of the globe. We present the preliminary results of bowl trapping in a Semidecidual Seasonal forest fragment in southern Brazil, including the test of two different color bowls, two different habitats, and the interaction of these variables in bee species number and composition. We used blue and yellow bowls in the border and in the core trails of the forest fragment. In five sampling days between October to December bowl traps captured 745 specimens of 37 morphospecies, with Halictinae bees being the richest and most abundant group. Non parametrical statistical analyses suggested that different colors of bowl traps influenced bee richness and composition and thus, they should be used together for a more complete sampling. Different trails influenced only the composition, while the interaction with different colors did not have a significant effect. These results, as well as the higher taxonomic composition of the inventoried bees, are similar to other studies reported in the literature.
Copes, Lynn E; Schutz, Heidi; Dlugosz, Elizabeth M; Acosta, Wendy; Chappell, Mark A; Garland, Theodore
2015-10-01
We evaluated the effect of voluntary exercise on spontaneous physical activity (SPA) and food consumption in mice from 4 replicate lines bred for 57 generations for high voluntary wheel running (HR) and from 4 non-selected control (C) lines. Beginning at ~24 days of age, mice were housed in standard cages or in cages with attached wheels. Wheel activity and SPA were monitored in 1-min intervals. Data from the 8th week of the experiment were analyzed because mice were sexually mature and had plateaued in body mass, weekly wheel running distance, SPA, and food consumption. Body mass, length, and masses of the retroperitoneal fat pad, liver, and heart were recorded after the 13th week. SPA of both HR and C mice decreased with wheel access, due to reductions in both duration and average intensity of SPA. However, total activity duration (SPA+wheel running; min/day) was ~1/3 greater when mice were housed with wheels, and food consumption was significantly increased. Overall, food consumption in both HR and C mice was more strongly affected by wheel running than by SPA. Duration of wheel running had a stronger effect than average speed, but the opposite was true for SPA. With body mass as a covariate, chronic wheel access significantly reduced fat pad mass and increased heart mass in both HR and C mice. Given that both HR and C mice housed with wheels had increased food consumption, the energetic cost of wheel running was not fully compensated by concomitant reductions in SPA. The experiment demonstrates that both duration and intensity of both wheel running and SPA were significant predictors of food consumption. This sort of detailed analysis of the effects of different aspects of physical activity on food consumption has not previously been reported for a non-human animal, and it sets the stage for longitudinal examination of energy balance and its components in rodent models. Copyright © 2015 Elsevier Inc. All rights reserved.
Preliminary design report for the NAC combined transport cask
International Nuclear Information System (INIS)
1990-04-01
Nuclear Assurance Corporation (NAC) is under contract to the United States Department of Energy (DOE) to design, license, develop and test models, and fabricate a prototype cask transportation system for nuclear spent fuel. The design of this combined transport (rail/barge) transportation system has been divided into two phases, a preliminary design phase and a final design phase. This Preliminary Design Package (PDP) describes the NAC Combined Transport Cask (NAC-CTC), the results of work completed during the preliminary design phase and identifies the additional detailed analyses, which will be performed during final design. Preliminary analytical results are presented in the appropriate sections and supplemented by summaries of procedures and assumptions for performing the additional detailed analyses of the final design. 60 refs., 1 fig., 2 tabs
Égüez, Natalia; Mallol, Carolina; Mangado, Xavier; Tejero, José Miguel; Fullola, Josep Maria
2014-05-01
We present preliminary data from ongoing microstratigraphic investigations of Cova del Parco (Lleida, Spain), a Magdalenian karstic cave site in North western Catalonia. Excavations of the Upper Magdalenian levels are currently underway, with radiometric dates between 15,690 and 16,390 cal BP. This period has yielded a complex anthropogenic sedimentary deposit including combustion features and local accumulations of anthropogenic debris near the cave walls. On of the working hypothesis is that the Magdalenian hunter-gatherers who occupied the site did so for short periods, possibly seasonally. Support of this hypothesis comes the presence of overlapping, very thin flat combustion structures, which appear to have been short-lived and close to each other in time. In order to investigate this issue, we carried out micromorphological analysis of some of the mentioned combustion features. Preliminary results show significant microstratification and presence of unburned spherulites mixed in with reprecipitated calcitic wood ash, both of which point towards the existence of hiatuses between combustion events. This is supported by the observation of scattered, lightly burned microscopic flint and bone fragments in the sediment between ash layers, which could represent renewed occupation floor debris. Our case study adds to the growing number of combustion feature microstratigraphic investigations contributing to a correct characterization of anthropogenic palimpsest deposits. Key words: Microstratigraphy; Micromorphology; Magdalenian; Combustion features; Wood ash; Palimpsest; Iberian Peninsula.
Kravchenko, E V; Ponteleeva, I V; Trofimov, S S; Lapa, V I; Ostrovskaia, R U; Voronina, T A
2009-01-01
The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice. Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties. Prolonged (five weeks) preliminary administration of noopept enhanced the anticonvulsant activity of valproate. This result justifies the joint chronic administration of noopept in combination with valproate in order to potentiate the anticonvulsant effect of the latter drug. In addition, the administration of noopept favorably influences the cognitive functions and suppresses the development of neurodegenerative processes.
The TETRA-II Experiment to Observe Terrestrial Gamma Flashes at Ground Level - Preliminary Results
Cherry, M. L.; Adams, C.; Al-Nussirat, S.; Bai, S.; Banadaki, Y.; Bitzer, P. M.; Hoffmann, J.; Khosravi, E.; Legault, M.; Orang, M.; Pleshinger, D. J.; Rodriguez, R.; Smith, D.; Trepanier, J. C.; Sunda-Meya, A.; Zimmer, N.
2017-12-01
An upgraded version of the TGF and Energetic Thunderstorm Rooftop Array (TETRA-II) consists of an array of BGO scintillators to detect bursts of gamma rays from thunderstorms at ground level in four separate locations: the campus of Louisiana State University in Baton Rouge, Louisiana; the campus of the University of Puerto Rico at Utuado, Puerto Rico; the Centro Nacional de Metrologia de Panama (CENAMEP) in Panama City, Panama; and the Severe Weather Institute and Radar & Lightning Laboratories in Huntsville, Alabama. The original TETRA-I array of NaI scintillators at Louisiana State University detected 37 millisecond-scale bursts of gamma rays at energies 50 keV-2 MeV associated with nearby (brief description of the TETRA-I observations, a description of TETRA-II, and preliminary results of the first events observed by TETRA-II will be presented including frequency and time history of events, spectral information, and correlation with local radar and radio data.
Search for dark companions of K and M giants - Preliminary results for Alpha Boo
Heyer, I.; Hall, D. N. B.; Hinkle, K.
1987-01-01
Preliminary results are presented for Alpha Boo, encompassing selected measurements during the period from January 1979 to June 1984. Four groups of data are chosen, each group taken within an interval of up to 1.5 months, and examined the internal consistency of each set to look for short term trends. The radial velocity was found to be very consistent with a standard deviation of about + or - 50 m/s within time scales of hours, days, and weeks. No significant radial velocity changes over these periods were detected. This suggests that the stellar surface activity is confined to the level of uncertainty. Because of this consistency it was possible to take the means of the radial velocity measurements within each group and compare them to look for possible long term changes. Variations of the radial velocity of about 200 m/s were found over the span of a few years, significant at the 6 to 8 sigma level.
Stroh, F.
2017-12-01
The StratoClim Aircraft Field Campaign employing the high-flying research aircraft M55 Geophysica was carried out from mid July to mid August of 2017 from Kathmandu, Nepal, covering the airspace of Nepal, India, Bangladesh and Myanmar in the frame of the EC FP7 funded StratoClim project (see the Rex. et al. overview in this session). In order to sample the first detailed data set on climate relevant processes of the Asian Summer Monsoon anticyclone a comprehensive chemical and aerosol payload of more than 2 metric tons consisting of 26 different instrumets was flown to altitudes in excess of 20km to measure remote sensing and in-situ data on dynamical, chemical, and micro-chemical processes governing this experimentally underresearched atmospheric domain. An overview of the instrumentation, observation strategies, and preliminary results on open challenges as the horizontal and vertical trace gas and aerosol structures, effects of convective events and the ATAL will be given.
Preliminary results of sup(40)Ca(e,e'c) reaction analysis c p,α, based on statistical model
International Nuclear Information System (INIS)
Herdade, S.B.; Emrich, H.J.
1990-01-01
Statistical model calculations relative to the reactions sup(40)Ca (e,e'p) sup(39)K and sup(40)Ca(e,e'P sub(o)) sup(39)K sup(gs), using a modified version of the program STAPRE are compared with experimental results obtained from coincidence experiments carried out at the Mainz microtron MAMI A. Preliminary results indicate that the statistical decay of a 1 sup(-) level in the sup(40)Ca compound nucleus, at an excitation energy + 20 MeV, to the ground state of the sup(39)K residual nucleus is only about 15% of the total decay, indicating that direct and/or semi-direct mechanisms contribute to the major part of the decay. (author)
Christensen, Karen E; Mikael, Leonie G; Leung, Kit-Yi; Lévesque, Nancy; Deng, Liyuan; Wu, Qing; Malysheva, Olga V; Best, Ana; Caudill, Marie A; Greene, Nicholas DE
2015-01-01
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. Objective: Our goal was to investigate the impact of high folic acid intake on liver disease and methyl metabolism. Design: Folic acid–supplemented diet (FASD, 10-fold higher than recommended) and control diet were fed to male Mthfr+/+ and Mthfr+/− mice for 6 mo to assess gene-nutrient interactions. Liver pathology, folate and choline metabolites, and gene expression in folate and lipid pathways were examined. Results: Liver and spleen weights were higher and hematologic profiles were altered in FASD-fed mice. Liver histology revealed unusually large, degenerating cells in FASD Mthfr+/− mice, consistent with nonalcoholic fatty liver disease. High folic acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced in FASD-fed mice. 5-Methyltetrahydrofolate, SAM, and SAM/S-adenosylhomocysteine ratios were lower in FASD and Mthfr+/− livers. Choline metabolites, including phosphatidylcholine, were reduced due to genotype and/or diet in an attempt to restore methylation capacity through choline/betaine-dependent SAM synthesis. Expression changes in genes of one-carbon and lipid metabolism were particularly significant in FASD Mthfr+/− mice. The latter changes, which included higher nuclear sterol regulatory element-binding protein 1, higher Srepb2 messenger RNA (mRNA), lower farnesoid X receptor (Nr1h4) mRNA, and lower Cyp7a1 mRNA, would lead to greater lipogenesis and reduced cholesterol catabolism into bile. Conclusions: We suggest that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency. This deficiency results in hepatocyte degeneration, suggesting a 2
Preliminary results of the PREFER FP7 Project
Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra
2014-05-01
The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to
International Nuclear Information System (INIS)
Reed, D.T.; Burnell, J.R.
1986-01-01
Rockwell Hanford Operations, under contract to the Department of Energy, is investigating the suitability of the Hanford site in the state of Washington as a high level nuclear waste repository. An important consideration in these investigations is the effect of ionizing radiation on the speciation of radionuclides in the groundwater after the high-level-waste container has been breached and there is direct contact between the groundwater and the waste form (controlled released period). The effect of ionizing radiation on radionuclide speciation depends on the radiation environment and site-specific chemistry near the waste container. With respect to these two aspects, the following results will be presented: a definition of the radiation environment during the controlled release period; preliminary site-specific experimental results: (1) basaltic systems spiked with radionuclides; (2) spent fuel-groundwater-basalt experiments
Preliminary Results of BTDF Calibration of Transmissive Solar Diffusers for Remote Sensing
Georgiev, Georgi T.; Butler, James J.; Thome, Kurt; Cooksey, Catherine; Ding, Leibo
2016-01-01
Satellite instruments operating in the reflected solar wavelength region require accurate and precise determination of the optical properties of their diffusers used in pre-flight and post-flight calibrations. The majority of recent and current space instruments use reflective diffusers. As a result, numerous Bidirectional Reflectance Distribution Function (BRDF) calibration comparisons have been conducted between the National Institute of Standards and Technology (NIST) and other industry and university-based metrology laboratories. However, based on literature searches and communications with NIST and other laboratories, no Bidirectional Transmittance Distribution Function (BTDF) measurement comparisons have been conducted between National Measurement Laboratories (NMLs) and other metrology laboratories. On the other hand, there is a growing interest in the use of transmissive diffusers in the calibration of satellite, air-borne, and ground-based remote sensing instruments. Current remote sensing instruments employing transmissive diffusers include the Ozone Mapping and Profiler Suite instrument (OMPS) Limb instrument on the Suomi-National Polar-orbiting Partnership (S-NPP) platform,, the Geostationary Ocean Color Imager (GOCI) on the Korea Aerospace Research Institute's (KARI) Communication, Ocean, and Meteorological Satellite (COMS), the Ozone Monitoring Instrument (OMI) on NASA's Earth Observing System (EOS) Aura platform, the Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument and the Geostationary Environmental Monitoring Spectrometer (GEMS).. This ensemble of instruments requires validated BTDF measurements of their on-board transmissive diffusers from the ultraviolet through the near infrared. This paper presents the preliminary results of a BTDF comparison between the NASA Diffuser Calibration Laboratory (DCL) and NIST on quartz and thin Spectralon samples.
Preliminary results of BTDF calibration of transmissive solar diffusers for remote sensing
Georgiev, Georgi T.; Butler, James J.; Thome, Kurt; Cooksey, Catherine; Ding, Leibo
2016-09-01
Satellite instruments operating in the reflected solar wavelength region require accurate and precise determination of the optical properties of their diffusers used in pre-flight and post-flight calibrations. The majority of recent and current space instruments use reflective diffusers. As a result, numerous Bidirectional Reflectance Distribution Function (BRDF) calibration comparisons have been conducted between the National Institute of Standards and Technology (NIST) and other industry and university-based metrology laboratories. However, based on literature searches and communications with NIST and other laboratories, no Bidirectional Transmittance Distribution Function (BTDF) measurement comparisons have been conducted between National Measurement Laboratories (NMLs) and other metrology laboratories. On the other hand, there is a growing interest in the use of transmissive diffusers in the calibration of satellite, air-borne, and ground-based remote sensing instruments. Current remote sensing instruments employing transmissive diffusers include the Ozone Mapping and Profiler Suite instrument (OMPS) Limb instrument on the Suomi-National Polar-orbiting Partnership (S-NPP) platform,, the Geostationary Ocean Color Imager (GOCI) on the Korea Aerospace Research Institute's (KARI) Communication, Ocean, and Meteorological Satellite (COMS), the Ozone Monitoring Instrument (OMI) on NASA's Earth Observing System (EOS) Aura platform, the Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument and the Geostationary Environmental Monitoring Spectrometer (GEMS).. This ensemble of instruments requires validated BTDF measurements of their onboard transmissive diffusers from the ultraviolet through the near infrared. This paper presents the preliminary results of a BTDF comparison between the NASA Diffuser Calibration Laboratory (DCL) and NIST on quartz and thin Spectralon samples.
Hoopes, Samantha L; Willcockson, Helen H; Caron, Kathleen M
2012-01-01
Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryonic lymphatic development. To determine the role of Calcrl in adulthood, we used an inducible Cre-loxP system to temporally and ubiquitously delete Calcrl in adult mice. Following tamoxifen injection, Calcrl(fl/fl)/CAGGCre-ER™ mice rapidly developed corneal edema and inflammation that was preceded by and persistently associated with dilated corneoscleral lymphatics. Lacteals and submucosal lymphatic capillaries of the intestine were also dilated, while mesenteric collecting lymphatics failed to properly transport chyle after an acute Western Diet, culminating in chronic failure of Calcrl(fl/fl)/CAGGCre-ER™ mice to gain weight. Dermal lymphatic capillaries were also dilated and chronic edema challenge confirmed significant and prolonged dermal lymphatic insufficiency. In vivo and in vitro imaging of lymphatics with either genetic or pharmacologic inhibition of AM signaling revealed markedly disorganized lymphatic junctional proteins ZO-1 and VE-cadherin. The maintenance of AM signaling during adulthood is required for preserving normal lymphatic permeability and function. Collectively, these studies reveal a spectrum of lymphatic defects in adult Calcrl(fl/fl)/CAGGCre-ER™ mice that closely recapitulate the clinical symptoms of patients with corneal, intestinal and peripheral lymphangiectasia.
Preliminary experimental results of tungsten wire-array Z-pinches on primary test stand
Energy Technology Data Exchange (ETDEWEB)
Huang, Xian-Bin; Zhou, Shao-Tong; Dan, Jia-Kun; Ren, Xiao-Dong, E-mail: amosrxd@163.com; Wang, Kun-Lun; Zhang, Si-Qun; Li, Jing; Xu, Qiang; Cai, Hong-Chun; Duan, Shu-Chao; Ouyang, Kai; Chen, Guang-Hua; Ji, Ce; Wei, Bing; Feng, Shu-Ping; Wang, Meng; Xie, Wei-Ping; Deng, Jian-Jun [Key Laboratory of Pulsed Power, Institute of Fluid Physics, China Academy of Engineering Physics, P.O. Box 919-108, Mianyang, Sichuan 621999 (China); Zhou, Xiu-Wen; Yang, Yi [Research Center of Laser Fusion, China Academy of Engineering Physics, P.O. Box 919-987, Mianyang, Sichuan 621999 (China)
2015-07-15
The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a 20 TW pulsed power driver, which can deliver a ∼10 MA, 70 ns rise-time (10%–90%) current to a short-circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. Preliminary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 13 mm to 30 mm, consisting of 132–300 tungsten wires with 5–10 μm in diameter. Multiple diagnostics were fielded to characterize the x-ray radiation from wire-array Z pinches. The x-ray peak power (∼50 TW) and total radiated energy (∼500 kJ) were obtained from a single 20-mm-diam array with 80-ns stagnation time. The highest x-ray peak power up to 80 TW with 2.4 ns FWHM was achieved by using a nested array with 20-mm outer diameter, and the total x-ray energy from the nested array is comparable to that of single array. Implosion velocity estimated from the time-resolved image measurement exceeds 30 cm/μs. The detailed experimental results and other findings are presented and discussed.
Hand-assisted Approach as a Model to Teach Complex Laparoscopic Hepatectomies: Preliminary Results.
Makdissi, Fabio F; Jeismann, Vagner B; Kruger, Jaime A P; Coelho, Fabricio F; Ribeiro-Junior, Ulysses; Cecconello, Ivan; Herman, Paulo
2017-08-01
Currently, there are limited and scarce models to teach complex liver resections by laparoscopy. The aim of this study is to present a hand-assisted technique to teach complex laparoscopic hepatectomies for fellows in liver surgery. Laparoscopic hand-assisted approach for resections of liver lesions located in posterosuperior segments (7, 6/7, 7/8, 8) was performed by the trainees with guidance and intermittent intervention of a senior surgeon. Data as: (1) percentage of time that the senior surgeon takes the surgery as main surgeon, (2) need for the senior surgeon to finish the procedure, (3) necessity of conversion, (4) bleeding with hemodynamic instability, (5) need for transfusion, (6) oncological surgical margins, were evaluated. In total, 12 cases of complex laparoscopic liver resections were performed by the trainee. All cases included deep lesions situated on liver segments 7 or 8. The senior surgeon intervention occurred in a mean of 20% of the total surgical time (range, 0% to 50%). A senior intervention >20% was necessary in 2 cases. There was no need for conversion or reoperation. Neither major bleeding nor complications resulted from the teaching program. All surgical margins were clear. This preliminary report shows that hand-assistance is a safe way to teach complex liver resections without compromising patient safety or oncological results. More cases are still necessary to draw definitive conclusions about this teaching method.
Inner ear dysfunction in caspase-3 deficient mice
Directory of Open Access Journals (Sweden)
Woo Minna
2011-10-01
Full Text Available Abstract Background Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient (Casp3-/- mouse strain. Results Average ABR thresholds of Casp3-/- mice were significantly elevated (P Casp3+/- mice and Casp3+/+ mice at 3 months of age. In DPOAE testing, distortion product 2F1-F2 was significantly decreased (P Casp3-/- mice, whereas Casp3+/- and Casp3+/+ mice showed normal and comparable values to each other. Casp3-/- mice were hyperactive and exhibited circling behavior when excited. In lateral canal VOR testing, Casp3-/- mice had minimal response to any of the stimuli tested, whereas Casp3+/- mice had an intermediate response compared to Casp3+/+ mice. Inner ear anatomical and histological analysis revealed gross hypomorphism of the vestibular organs, in which the main site was the anterior semicircular canal. Hair cell numbers in the anterior- and lateral crista, and utricle were significantly smaller in Casp3-/- mice whereas the Casp3+/- and Casp3+/+ mice had normal hair cell numbers. Conclusions These results indicate that caspase-3 is essential for correct functioning of the cochlea as well as normal development and function of the vestibule.
Mid-latitude Geomagnetic Field Analysis Using BOH Magnetometer: Preliminary Results
Directory of Open Access Journals (Sweden)
Junga Hwang
2011-09-01
Full Text Available Korea Astronomy and Space Science Institute researchers have installed and operated magnetometers at Mt. Bohyun Observatory to measure the Earth's magnetic field variations in South Korea. We, in 2007, installed a fluxgate magnetometer (RFP-523C to measure H, D, and Z components of the geomagnetic field. In addition, in 2009, we installed a Overhauser proton sensor to measure the absolute total magnetic field F and a three-axis magneto-impedance sensor for spectrum analysis. Currently three types of magnetometer data have been accumulated. In this paper, we provide the preliminary and the first statistical analysis using the BOH magnetometer installed at Mt. Bohyun Observatory. By superposed analysis, we find that daily variations of H, D, and Z shows similar tendency, that is, about 30 minutes before the meridian (11:28 a minimum appears and the time after about 3 hours and 30 minutes (15:28 a maximum appears. Also, a quiet interval start time (19:06 is near the sunset time, and a quiet interval end time (06:40 is near the sunrise time. From the sunset to the sunrise, the value of H has a nearly constant interval, that is, the sun affects the changes in H values. Seasonal variations show similar dependences to the sun. Local time variations show that noon region has the biggest variations and midnight region has the smallest variations. We compare the correlations between geomagnetic variations and activity indices as we expect the geomagnetic variation would contain the effects of geomagnetic activity variations. As a result, the correlation coefficient between H and Dst is the highest (r = 0.947, and other AL, AE, AU index and showed a high correlation. Therefore, the effects of geomagnetic storms and geomagnetic substorms might contribute to the geomagnetic changes significantly.
New method of scoliosis assessment: preliminary results using computerized photogrammetry.
Aroeira, Rozilene Maria Cota; Leal, Jefferson Soares; de Melo Pertence, Antônio Eustáquio
2011-09-01
A new method for nonradiographic evaluation of scoliosis was independently compared with the Cobb radiographic method, for the quantification of scoliotic curvature. To develop a protocol for computerized photogrammetry, as a nonradiographic method, for the quantification of scoliosis, and to mathematically relate this proposed method with the Cobb radiographic method. Repeated exposure to radiation of children can be harmful to their health. Nevertheless, no nonradiographic method until now proposed has gained popularity as a routine method for evaluation, mainly due to a low correspondence to the Cobb radiographic method. Patients undergoing standing posteroanterior full-length spine radiographs, who were willing to participate in this study, were submitted to dorsal digital photography in the orthostatic position with special surface markers over the spinous process, specifically the vertebrae C7 to L5. The radiographic and photographic images were sent separately for independent analysis to two examiners, trained in quantification of scoliosis for the types of images received. The scoliosis curvature angles obtained through computerized photogrammetry (the new method) were compared to those obtained through the Cobb radiographic method. Sixteen individuals were evaluated (14 female and 2 male). All presented idiopathic scoliosis, and were between 21.4 ± 6.1 years of age; 52.9 ± 5.8 kg in weight; 1.63 ± 0.05 m in height, with a body mass index of 19.8 ± 0.2. There was no statistically significant difference between the scoliosis angle measurements obtained in the comparative analysis of both methods, and a mathematical relationship was formulated between both methods. The preliminary results presented demonstrate equivalence between the two methods. More studies are needed to firmly assess the potential of this new method as a coadjuvant tool in the routine following of scoliosis treatment.
COSMIC EVOLUTION OF DUST IN GALAXIES: METHODS AND PRELIMINARY RESULTS
International Nuclear Information System (INIS)
Bekki, Kenji
2015-01-01
We investigate the redshift (z) evolution of dust mass and abundance, their dependences on initial conditions of galaxy formation, and physical correlations between dust, gas, and stellar contents at different z based on our original chemodynamical simulations of galaxy formation with dust growth and destruction. In this preliminary investigation, we first determine the reasonable ranges of the most important two parameters for dust evolution, i.e., the timescales of dust growth and destruction, by comparing the observed and simulated dust mass and abundances and molecular hydrogen (H 2 ) content of the Galaxy. We then investigate the z-evolution of dust-to-gas ratios (D), H 2 gas fraction (f H 2 ), and gas-phase chemical abundances (e.g., A O = 12 + log (O/H)) in the simulated disk and dwarf galaxies. The principal results are as follows. Both D and f H 2 can rapidly increase during the early dissipative formation of galactic disks (z ∼ 2-3), and the z-evolution of these depends on initial mass densities, spin parameters, and masses of galaxies. The observed A O -D relation can be qualitatively reproduced, but the simulated dispersion of D at a given A O is smaller. The simulated galaxies with larger total dust masses show larger H 2 and stellar masses and higher f H 2 . Disk galaxies show negative radial gradients of D and the gradients are steeper for more massive galaxies. The observed evolution of dust masses and dust-to-stellar-mass ratios between z = 0 and 0.4 cannot be reproduced so well by the simulated disks. Very extended dusty gaseous halos can be formed during hierarchical buildup of disk galaxies. Dust-to-metal ratios (i.e., dust-depletion levels) are different within a single galaxy and between different galaxies at different z
COSMIC EVOLUTION OF DUST IN GALAXIES: METHODS AND PRELIMINARY RESULTS
Energy Technology Data Exchange (ETDEWEB)
Bekki, Kenji [ICRAR, M468, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009 (Australia)
2015-02-01
We investigate the redshift (z) evolution of dust mass and abundance, their dependences on initial conditions of galaxy formation, and physical correlations between dust, gas, and stellar contents at different z based on our original chemodynamical simulations of galaxy formation with dust growth and destruction. In this preliminary investigation, we first determine the reasonable ranges of the most important two parameters for dust evolution, i.e., the timescales of dust growth and destruction, by comparing the observed and simulated dust mass and abundances and molecular hydrogen (H{sub 2}) content of the Galaxy. We then investigate the z-evolution of dust-to-gas ratios (D), H{sub 2} gas fraction (f{sub H{sub 2}}), and gas-phase chemical abundances (e.g., A {sub O} = 12 + log (O/H)) in the simulated disk and dwarf galaxies. The principal results are as follows. Both D and f{sub H{sub 2}} can rapidly increase during the early dissipative formation of galactic disks (z ∼ 2-3), and the z-evolution of these depends on initial mass densities, spin parameters, and masses of galaxies. The observed A {sub O}-D relation can be qualitatively reproduced, but the simulated dispersion of D at a given A {sub O} is smaller. The simulated galaxies with larger total dust masses show larger H{sub 2} and stellar masses and higher f{sub H{sub 2}}. Disk galaxies show negative radial gradients of D and the gradients are steeper for more massive galaxies. The observed evolution of dust masses and dust-to-stellar-mass ratios between z = 0 and 0.4 cannot be reproduced so well by the simulated disks. Very extended dusty gaseous halos can be formed during hierarchical buildup of disk galaxies. Dust-to-metal ratios (i.e., dust-depletion levels) are different within a single galaxy and between different galaxies at different z.
Energy Technology Data Exchange (ETDEWEB)
Saroja, K. R. [Unlisted, US, IL; Cohen, Lionel [Unlisted, US, IL; Hendrickson, Frank R. [Unlisted, US, IL; Mansell, JoAnne [Fermilab
1990-01-01
Between January 1985 and July 1989 a total of thirty-eight patients with locally advanced pancreatic cancer were treated with high energy neutrons at Fermilab. Twenty-one patients received only neutrons and seventeen were given chemotherapy in addition, either concurrently or subsequently following the completion of neutron irradiation. This is a retrospective study. Data were analyzed for tolerance, complications and survival. Three of the twenty-one (14%) patients who received only neutron beam therapy developed Grade ID or greater complications in the RTOG/EORTC scale. The median survival was 6.4 months. One of these patients is alive 10 months post treatment. Of seventeen patients who also received chemotherapy, five (29%) had severe complications. However, median survival was 13.5 months. Four of these seventeen patients are still alive at the time of this analysis. The preliminary results show that there is improvement in the survival of patients treated with combined neutron irradiation and chemotherapy. A pilot study to further evaluate these results in a larger group of patients is underway. Details of complications and chemotherapy regimen will be preseqted.
Cocciaro, B.; Faetti, S.; Fronzoni, L.
2017-08-01
As shown in the EPR paper (Einstein, Podolsky e Rosen, 1935), Quantum Mechanics is a non-local Theory. The Bell theorem and the successive experiments ruled out the possibility of explaining quantum correlations using only local hidden variables models. Some authors suggested that quantum correlations could be due to superluminal communications that propagate isotropically with velocity vt > c in a preferred reference frame. For finite values of vt and in some special cases, Quantum Mechanics and superluminal models lead to different predictions. So far, no deviations from the predictions of Quantum Mechanics have been detected and only lower bounds for the superluminal velocities vt have been established. Here we describe a new experiment that increases the maximum detectable superluminal velocities and we give some preliminary results.
Technetium removal: preliminary flowsheet options
International Nuclear Information System (INIS)
Eager, K.M.
1995-01-01
This document presents the results of a preliminary investigation into options for preliminary flowsheets for 99Tc removal from Hanford Site tank waste. A model is created to show the path of 99Tc through pretreatment to disposal. The Tank Waste Remediation (TWRS) flowsheet (Orme 1995) is used as a baseline. Ranges of important inputs to the model are developed, such as 99Tc inventory in the tanks and important splits through the TWRS flowsheet. Several technetium removal options are discussed along with sensitivities of the removal schemes to important model parameters
Synergistic interaction between the neutron and gamma radiation on LACA mice hemopoietic stem cells
Energy Technology Data Exchange (ETDEWEB)
Xu, H
1982-02-01
Based on the radiation action dual theory of DNA single and double strand breaks, a hypothetical RBE mathematical model for the effect of the mixed radiation of neutron and gamma rays on LACA mice hemopoietic stem cells was formulated. In comparison of the RBE values of different ratio of neutron and gamma-ray mixed radiation with their theoretical additive RBE values, the preliminary impression is that the mixed radiation is more effective than that of the theoretical additive effect. It seems that the existence of synergist in the mixed radiation might be valid.
Rensen, Sander S.; Niessen, Petra M.; van Deursen, Jan M.; Janssen, Ben J.; Heijman, Edwin; Hermeling, Evelien; Meens, Merlijn; Lie, Natascha; Gijbels, Marion J.; Strijkers, Gustav J.; Doevendans, Pieter A.; Hofker, Marten H.; de Mey, Jo G. R.; van Eys, Guillaume J.
2008-01-01
Smoothelins are actin-binding proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. Their expression is strongly associated with the contractile phenotype of smooth muscle cells. Analysis of mice lacking both smoothelins (Smtn-A/B(-/-)
The development and preliminary testing of new boronated agents for BNCT based on PET derived data
International Nuclear Information System (INIS)
Nichols, T.; Kabalka, G.; Kahn, M.; Das, B.; Das, S.; Bao, W.; Miller, L.
2000-01-01
Positron emission tomography (PET) has been utilized at the University of Tennessee for evaluating a variety of tumors including glioblastoma multiforme (GBM) and metastatic malignant melanoma (MM). Studies have been carried out utilizing fluorine-18 labeled p-boronophenylalanine ( 18 F-BPA) and other unnatural amino acids. A comparison of PET studies obtained using 18 F-BPA and a carbon-11 labeled cyclobutane-based amino acid ( 11 C-ACBC) revealed that 11 C-ACBC localized effectively in GBM tumors. Based on these results, we have prepared a series of boronated, aminocyclobutanecarboxylic acids. Preliminary uptake and cell toxicity studies have been carried out and show that many of the agents are not toxic. In one instance, a biodistribution study carried out using nude mice implanted with a human glioblastoma tumor, the tumor to normal tissue uptake of boron exceeds that observed for BPA. (author)
Mineral-microorganism interactions in Acid Mine Drainage environments: preliminary results
Carbone, Cristina; Zotti, Mirca; Pozzolini, Marina; Giovine, Marco; Di Piazza, Simone; Mariotti, Mauro; Lucchetti, Gabriella
2014-05-01
Minerals play a key role in controlling the mobility and distribution of metals and metalloids of environmental concern in supergenic environments. These are involved in a variety of processes, spanning the alteration of primary minerals to the formation of secondary authigenic phases and can represent a source or a trap for Potentially Ecotoxic Elements (PTEs). Soil, sediments, and waters heavily polluted with PTEs through AMD processes are a reservoir of a unusual bacteria and fungi well adapted to these toxic environments. Classical studies of biotic weathering have mainly focused on water-mineral interaction and on the ability of microorganism to influence the soil solution chemical composition. In this work, we analyzed two different representative ochreous and greenish-blue AMD colloidal precipitates in order to i) characterize the biota population present in these colloidal minerals and ii) verify the bioaccumulation of PTEs into the fungi and the potential impact of bacteria in the geochemistry of the system. The samples are composed by nanocrystalline goethite which contains high amounts of Fe, Cu, Zn, Pb, and Ni and woodwardite that is characterized by Cu, Zn, Ni, Y, and Ce. These precipitates were examined in order to evaluate the presence of fungal strains and to extract bacteria DNA. The preliminary results of fungi characterization show an interesting and selected mycobiota able to survive under unfavourable environmental conditions. A significant number of fungal strains was isolated in pure culture. Most of them belong to the genus Mucor and Penicillium. It is worth noting the presence of Trametes versicolor, a macrofungal lignicolous species already known for heavy metal biosorption capability from aqueous solution (Gülay et al 2003). The same colloidal precipitates have been processed to extract bacteria DNA, using a specific procedure developed for DNA extraction from sediments. The results gave a good yield of nucleic acids and the positive PCR
Directory of Open Access Journals (Sweden)
Sonia Martinez-Herrero
2016-11-01
Full Text Available The link between intestinal inflammation, microbiota, and colorectal cancer (CRC is intriguing and the potential underlying mechanisms remain unknown. Here we evaluate the influence of adrenomedullin (AM in microbiota composition and its impact on colitis with an inducible knockout (KO mouse model for AM. Microbiota composition was analyzed in KO and wild type (WT mice by pyrosequencing. Colitis was induced in mice by administration of azoxymethane (AOM followed by dextran sulfate sodium (DSS in the drinking water. Colitis was evaluated using a clinical symptoms index, histopathological analyses, and qRT-PCR. Abrogation of the adm gene in the whole body was confirmed by PCR and qRT-PCR. KO mice exhibit significant changes in colonic microbiota: higher proportion of δ-Proteobacteria class; of Coriobacteriales order; and of other families and genera was observed in KO feces. Meanwhile these mice had a lower proportion of beneficial bacteria, such as Lactobacillus gasseri and Bifidobacterium choerinum. TLR4 gene expression was higher (p<0.05 in KO animals. AM deficient mice treated with DSS exhibited a significantly worse colitis with profound weight loss, severe diarrhea, rectal bleeding, colonic inflammation, edema, infiltration, crypt destruction, and higher levels of pro-inflammatory cytokines. No changes were observed in the expression levels of adhesion molecules. In conclusion, we have shown that lack of AM leads to changes in gut microbiota population and in a worsening of colitis conditions, suggesting that endogenous AM is a protective mediator in this pathology.
DEFF Research Database (Denmark)
Lindholt, Jes Sanddal; Juul, Søren; Fasting, H
2006-01-01
At present, several regions and countries are considering screening for abdominal aortic aneurysm (AAA). However, The Chichester Aneurysms Screening Trial has reported poor long term benefit of screening for AAA. We therefore supplement previously published data with a preliminary analysis...
An, Dong; Chen, Wei; Yu, De-Qin; Wang, Shi-Wei; Yu, Wei-Zhi; Xu, Hong; Wang, Dong-Mei; Zhao, Dan; Sun, Yi-Ping; Wu, Jun-Cheng; Tang, Yi-Yuan; Yin, Sheng-Ming
2017-05-01
Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress-associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age-matched controls were evaluated using object recognition, object location and resident-intruder tests. The recovery of behavioral deficits by re-socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re-socialization could completely recover spatial/non-spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non-spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions. © 2016 Japanese Society of Animal Science.
Preliminary Hazard Classification for the 105-B Reactor
International Nuclear Information System (INIS)
Kerr, N.R.
1997-08-01
This document summarizes the inventories of radioactive and hazardous materials present within the 105-B Reactor and uses the inventory information to determine the preliminary hazard classification for the surveillance and maintenance activities of the facility. The result of this effort was the preliminary hazard classification for the 105-B Building surveillance and maintenance activities. The preliminary hazard classification was determined to be Nuclear Category 3. Additional hazard and accident analysis will be documented in a separate report to define the hazard controls and final hazard classification
Cell-extrinsic defective lymphocyte development in Lmna(-/- mice.
Directory of Open Access Journals (Sweden)
J Scott Hale
2010-04-01
Full Text Available Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/- mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies. Lmna(-/- mice also display smaller spleens and thymuses. In this study, we investigated whether altered lymphoid organ sizes are correlated with specific defects in lymphocyte development.Lmna(-/- mice displayed severe age-dependent defects in T and B cell development which coincided with runting. Lmna(-/- bone marrow reconstituted normal T and B cell development in irradiated wild-type recipients, driving generation of functional and self-MHC restricted CD4(+ and CD8(+ T cells. Transplantation of Lmna(-/- neonatal thymus lobes into syngeneic wild-type recipients resulted in good engraftment of thymic tissue and normal thymocyte development.Collectively, these data demonstrate that the severe defects in lymphocyte development that characterize Lmna(-/- mice do not result directly from the loss of A-type lamin function in lymphocytes or thymic stroma. Instead, the immune defects in Lmna(-/- mice likely reflect indirect damage, perhaps resulting from prolonged stress due to the striated muscle dystrophies that occur in these mice.
Directory of Open Access Journals (Sweden)
Samantha L Hoopes
Full Text Available Adrenomedullin (AM and its receptor complexes, calcitonin receptor-like receptor (Calcrl and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryonic lymphatic development. To determine the role of Calcrl in adulthood, we used an inducible Cre-loxP system to temporally and ubiquitously delete Calcrl in adult mice. Following tamoxifen injection, Calcrl(fl/fl/CAGGCre-ER™ mice rapidly developed corneal edema and inflammation that was preceded by and persistently associated with dilated corneoscleral lymphatics. Lacteals and submucosal lymphatic capillaries of the intestine were also dilated, while mesenteric collecting lymphatics failed to properly transport chyle after an acute Western Diet, culminating in chronic failure of Calcrl(fl/fl/CAGGCre-ER™ mice to gain weight. Dermal lymphatic capillaries were also dilated and chronic edema challenge confirmed significant and prolonged dermal lymphatic insufficiency. In vivo and in vitro imaging of lymphatics with either genetic or pharmacologic inhibition of AM signaling revealed markedly disorganized lymphatic junctional proteins ZO-1 and VE-cadherin. The maintenance of AM signaling during adulthood is required for preserving normal lymphatic permeability and function. Collectively, these studies reveal a spectrum of lymphatic defects in adult Calcrl(fl/fl/CAGGCre-ER™ mice that closely recapitulate the clinical symptoms of patients with corneal, intestinal and peripheral lymphangiectasia.
The preliminary results: Internal seismic velocity structure imaging beneath Mount Lokon
Energy Technology Data Exchange (ETDEWEB)
Firmansyah, Rizky, E-mail: rizkyfirmansyah@hotmail.com [Geophysical Engineering, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysical Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Bandung, 40132 (Indonesia); Kristianto, E-mail: kris@vsi.esdm.go.id [Center for Volcanology and Geological Hazard Mitigation (CVGHM), Geological Agency, Bandung, 40122 (Indonesia)
2015-04-24
Historical records that before the 17{sup th} century, Mount Lokon had been dormant for approximately 400 years. In the years between 1350 and 1400, eruption ever recorded in Empung, came from Mount Lokon’s central crater. Subsequently, in 1750 to 1800, Mount Lokon continued to erupt again and caused soil damage and fall victim. After 1949, Mount Lokon dramatically increased in its frequency: the eruption interval varies between 1 – 5 years, with an average interval of 3 years and a rest interval ranged from 8 – 64 years. Then, on June 26{sup th}, 2011, standby alert set by the Center for Volcanology and Geological Hazard Mitigation. Peak activity happened on July 4{sup th}, 2011 that Mount Lokon erupted continuously until August 28{sup th}, 2011. In this study, we carefully analyzed micro-earthquakes waveform and determined hypocenter location of those events. We then conducted travel time seismic tomographic inversion using SIMULPS12 method to detemine Vp, Vs and Vp/Vs ratio structures beneath Lokon volcano in order to enhance our subsurface geological structure. During the tomographic inversion, we started from 1-D seismic velocities model obtained from VELEST33 method. Our preliminary results show low Vp, low Vs, and high Vp/Vs are observed beneath Mount Lokon-Empung which are may be associated with weak zone or hot material zones. However, in this study we used few station for recording of micro-earthquake events. So, we suggest in the future tomography study, the adding of some seismometers in order to improve ray coverage in the region is profoundly justified.
Preliminary results of geologic and remote sensing studies of Rima Mozart
International Nuclear Information System (INIS)
Coombs, C.R.; Hawke, B.R.
1987-01-01
In order to better understand the processes responsible for the formation of lunar sinuous rilles, a study of Rima Mozart was conducted using a variety of geologic, photographic, and remote sensing data. The apparent source of this rille is located in a highlands unit of known composition and it is hypothesized that thermal and mechanical erosion played an important role in the formation of Rima Mozart. Excellent photographic, topographic, multispectral, and radar data exist for this rille. The preliminary results of an analysis of this data are presented. Photographic data indicates the presence of two volcanic source vents for Rima Mozart: Kathleen and Ann. It is suggested that Rima Mozart, like many other lunar sinuous rilles, was most likely formed by a combination of events. Rima Mozart does follow a pre-existing, dominant NW/SE structural trend suggesting the influence of structural features on the rille, however, the tectonic influence is not the sole source for the formation of the rille, as suggested by the presence of the two source vents and the spatter around Ann. It is suggested that the rille formation began with an explosive eruption at Kathleen which later calmed down to a pulsating, high volume, low-viscosity lava flow. The rapid effusion rate of the magma as well as its high temperature and turbid nature helped carve the sinuous rille into the fractured and structurally weak Apennine Bench Formation underneath. Similar eruptions and subsequent flows were also created at Ann and joined to the main channel by a NE-trending secondary rille
Preliminary results of geologic and remote sensing studies of Rima Mozart
Coombs, C. R.; Hawke, B. R.
1987-01-01
In order to better understand the processes responsible for the formation of lunar sinuous rilles, a study of Rima Mozart was conducted using a variety of geologic, photographic, and remote sensing data. The apparent source of this rille is located in a highlands unit of known composition and it is hypothesized that thermal and mechanical erosion played an important role in the formation of Rima Mozart. Excellent photographic, topographic, multispectral, and radar data exist for this rille. The preliminary results of an analysis of this data are presented. Photographic data indicates the presence of two volcanic source vents for Rima Mozart: Kathleen and Ann. It is suggested that Rima Mozart, like many other lunar sinuous rilles, was most likely formed by a combination of events. Rima Mozart does follow a pre-existing, dominant NW/SE structural trend suggesting the influence of structural features on the rille, however, the tectonic influence is not the sole source for the formation of the rille, as suggested by the presence of the two source vents and the spatter around Ann. It is suggested that the rille formation began with an explosive eruption at Kathleen which later calmed down to a pulsating, high volume, low-viscosity lava flow. The rapid effusion rate of the magma as well as its high temperature and turbid nature helped carve the sinuous rille into the fractured and structurally weak Apennine Bench Formation underneath. Similar eruptions and subsequent flows were also created at Ann and joined to the main channel by a NE-trending secondary rille.
Percutaneous Irreversible Electroporation Lung Ablation: Preliminary Results in a Porcine Model
International Nuclear Information System (INIS)
Deodhar, Ajita; Monette, Sébastien; Single, Gordon W.; Hamilton, William C.; Thornton, Raymond H.; Sofocleous, Constantinos T.; Maybody, Majid; Solomon, Stephen B.
2011-01-01
Objective: Irreversible electroporation (IRE) uses direct electrical pulses to create permanent “pores” in cell membranes to cause cell death. In contrast to conventional modalities, IRE has a nonthermal mechanism of action. Our objective was to study the histopathological and imaging features of IRE in normal swine lung. Materials and Methods: Eleven female swine were studied for hyperacute (8 h), acute (24 h), subacute (96 h), and chronic (3 week) effects of IRE ablation in lung. Paired unipolar IRE applicators were placed under computed tomography (CT) guidance. Some applicators were deliberately positioned near bronchovascular structures. IRE pulse delivery was synchronized with the cardiac rhythm only when ablation was performed within 2 cm of the heart. Contrast-enhanced CT scan was performed immediately before and after IRE and at 1 and 3 weeks after IRE ablation. Representative tissue was stained with hematoxylin and eosin for histopathology. Results: Twenty-five ablations were created: ten hyperacute, four acute, and three subacute ablations showed alveolar edema and necrosis with necrosis of bronchial, bronchiolar, and vascular epithelium. Bronchovascular architecture was maintained. Chronic ablations showed bronchiolitis obliterans and alveolar interstitial fibrosis. Immediate post-procedure CT images showed linear or patchy density along the applicator tract. At 1 week, there was consolidation that resolved partially or completely by 3 weeks. Pneumothorax requiring chest tube developed in two animals; no significant cardiac arrhythmias were noted. Conclusion: Our preliminary porcine study demonstrates the nonthermal and extracellular matrix sparing mechanism of action of IRE. IRE is a potential alternative to thermal ablative modalities.
The Geographic Climate Information System Project (GEOCLIMA): Overview and preliminary results
Feidas, H.; Zanis, P.; Melas, D.; Vaitis, M.; Anadranistakis, E.; Symeonidis, P.; Pantelopoulos, S.
2012-04-01
The project GEOCLIMA aims at developing an integrated Geographic Information System (GIS) allowing the user to manage, analyze and visualize the information which is directly or indirectly related to climate and its future projections in Greece. The main components of the project are: a) collection and homogenization of climate and environmental related information, b) estimation of future climate change based on existing regional climate model (RCM) simulations as well as a supplementary high resolution (10 km x 10 km) simulation over the period 1961-2100 using RegCM3, c) compilation of an integrated uniform geographic database, and d) mapping of climate data, creation of digital thematic maps, and development of the integrated web GIS application. This paper provides an overview of the ongoing research efforts and preliminary results of the project. First, the trends in the annual and seasonal time series of precipitation and air temperature observations for all available stations in Greece are assessed. Then the set-up of the high resolution RCM simulation (10 km x 10 km) is discussed with respect to the selected convective scheme. Finally, the relationship of climatic variables with geophysical features over Greece such as altitude, location, distance from the sea, slope, aspect, distance from climatic barriers, land cover etc) is investigated, to support climate mapping. The research has been co-financed by the European Union (European Regional Development Fund) and Greek national funds through the Operational Program "Competitiveness and Entrepreneurship" of the National Strategic Reference Framework (NSRF) - Research Funding Program COOPERATION 2009.
2013-02-06
... business because it has English and French customers. Because of this, we will treat Foliot Furniture Inc... electronically via Import Administration's Antidumping and Countervailing Duty Centralized Electronic Service...://www.trade.gov/ia/ . The signed Preliminary Decision Memorandum and the electronic versions of the...
Berghout, N.A.; Kuramochi, T.; van den Broek, M.A.; Ramirez, C.A.; Faaij, A.P.C.
2013-01-01
This paper evaluated the techno economic performance of several CO2 capture-network configurations for a cluster of sixteen industrial plants in the Netherlands using bottom up analysis. Preliminary findings indicate that centralizing capture equipment instead of capture equipment at plant sites
Mani, Lara; Cole, Paul D.; Stewart, Iain
2016-07-01
This paper presents the findings from a study aimed at understanding whether video games (or serious games) can be effective in enhancing volcanic hazard education and communication. Using the eastern Caribbean island of St. Vincent, we have developed a video game - St. Vincent's Volcano - for use in existing volcano education and outreach sessions. Its twin aims are to improve residents' knowledge of potential future eruptive hazards (ash fall, pyroclastic flows and lahars) and to integrate traditional methods of education in a more interactive manner. Here, we discuss the process of game development including concept design through to the final implementation on St. Vincent. Preliminary results obtained from the final implementation (through pre- and post-test knowledge quizzes) for both student and adult participants provide indications that a video game of this style may be effective in improving a learner's knowledge. Both groups of participants demonstrated a post-test increase in their knowledge quiz score of 9.3 % for adults and 8.3 % for students and, when plotted as learning gains (Hake, 1998), show similar overall improvements (0.11 for adults and 0.09 for students). These preliminary findings may provide a sound foundation for the increased integration of emerging technologies within traditional education sessions. This paper also shares some of the challenges and lessons learnt throughout the development and testing processes and provides recommendations for researchers looking to pursue a similar study.
Preliminary results for HIP bonding Ta to W targets for the materials test station
Energy Technology Data Exchange (ETDEWEB)
Dombrowski, David E [Los Alamos National Laboratory; Maloy, Stuart A [Los Alamos National Laboratory
2009-01-01
Tungsten targets for the Materials Test Station (MTS) were clad with thin tantalum cover plates and a tantalum frame using hot isostatic pressing (HIP). A preliminary HIP parameter study showed good bonding and intimate mechanical contact for Ta cover plate thicknesses of 0.25 mm (0.010 inch) and 0.38 mm (0.015 inch). HIP temperatures of full HIP runs were 1500 C (2732 F). HIP pressure was 203 MPa (30 ksi).
Euthanasia of neonatal mice with carbon dioxide
Pritchett, K.; Corrow, D.; Stockwell, J.; Smith, A.
2005-01-01
Exposure to carbon dioxide (CO2) is the most prevalent method used to euthanize rodents in biomedical research. The purpose of this study was to determine the time of CO2 exposure required to euthanize neonatal mice (0 to 10 days old). Multiple groups of mice were exposed to 100% CO 2 for time periods between 5 and 60 min. Mice were placed in room air for 10 or 20 min after CO2 exposure, to allow for the chance of recovery. If mice recovered at one time point, a longer exposure was examined. Inbred and outbred mice were compared. Results of the study indicated that time to death varied with the age of the animals and could be as long as 50 min on the day of birth and differed between inbred and outbred mice. Institutions euthanizing neonatal mice with CO2 may wish to adjust their CO 2 exposure time periods according the age of the mice and their genetic background. Copyright 2005 by the American Association for Laboratory Animal Science.
Ikarashi, Nobutomo; Kagami, Mai; Kobayashi, Yasushi; Ishii, Makoto; Toda, Takahiro; Ochiai, Wataru; Sugiyama, Kiyoshi
2011-06-01
In humans, digoxin is mainly eliminated through the kidneys unchanged, and renal clearance represents approximately 70% of the total clearance. In this study, we used the mouse models to examine digoxin pharmacokinetics in polyuria induced by diabetes mellitus and lithium carbonate (Li(2)CO(3)) administration, including mechanistic evaluation of the contribution of glomerular filtration, tubular secretion, and tubular reabsorption. After digoxin administration to streptozotocin (STZ)-induced diabetic mice, digoxin CL/F increased to approximately 2.2 times that in normal mice. After treatment with Li(2)CO(3) (0.2%) for 10 days, the CL/F increased approximately 1.1 times for normal mice and 1.6 times for STZ mice. Creatinine clearance (CLcr) and the renal mRNA expression levels of mdr1a did not differ significantly between the normal, STZ, and Li(2)CO(3)-treated mice. The urine volume of STZ mice was approximately 26 mL/day, 22 times that of normal mice. The urine volume of Li(2)CO(3)-treated mice increased approximately 7.3 times for normal mice and 2.3 times for STZ mice. These results suggest that the therapeutic effect of digoxin may be significantly reduced in the presence of polyuria either induced by diabetes mellitus or manifested as an adverse effect of Li(2)CO(3) in diabetic patients, along with increased urine volume.
PRELIMINARY RESULTS OF ESTIMATING SOIL MOISTURE OVER BARE SOIL USING FULL-POLARIMETRIC ALOS-2 DATA
Directory of Open Access Journals (Sweden)
A. Sekertekin
2016-10-01
Full Text Available Synthetic Aperture Radar (SAR imaging system is one of the most effective way for Earth observation. The aim of this study is to present the preliminary results about estimating soil moisture using L-band Synthetic Aperture Radar (SAR data. Full-polarimetric (HH, HV, VV, VH ALOS-2 data, acquired on 22.04.2016 with the incidence angle of 30.4o, were used in the study. Simultaneously with the SAR acquisition, in-situ soil moisture samples over bare agricultural lands were collected and evaluated using gravimetric method. Backscattering coefficients for all polarizations were obtained and linear regression analysis was carried out with in situ moisture measurements. The best correlation coefficient was observed with VV polarization. Cross-polarized backscattering coefficients were not so sensitive to soil moisture content. In the study, it was observed that soil moisture maps can be retrieved with the accuracy about 14% (RMSE.
International Nuclear Information System (INIS)
Seka, R.; Amiel, M.; Boller, A.; Chapelon, C.; Clermont, A.; Revel, D.; Pinet, F.
1988-01-01
Digital subtraction angiography (DSA) as a method of evaluating lower limb arteries required examination of one limb at a time up to now. Moreover repeated injections of contrast material were necessary. This problem was mainly due to the relative small image intensifier field available and to the difficulty of repositionning the patient between mask and image acquisition. The preliminary results obtained with 24 patients studied on angiographic unit equipped with: a DSA system (DG 300-CGR) using 512x512 matrix size, an angiographic table (Angix M 200) allowing an automatic sequantial translation, a removable image intensifier using a 16 inch field below the table, are reported. Thus, all those characteristics allow DSA of lower limb arteries. Only one injection of contrast material (Ioxaglate: 80 ml at 8-10 ml/second) was used per procedure. This, usually, allows good quality examination of lower limb arteries [fr
Scope and purpose of the preliminary planning work
International Nuclear Information System (INIS)
Kalas, P.
1976-01-01
The results of preliminary planning work are usually expressed in a number of recommendations covering mainly: long-term national policy in the field of energy resources and selection of projects to be further studied at the feasibility level. Moreover, recommendations on further actions are made including: inventory of generation and transmission facilities recommended for the implementation in order to meet the load forecasted for medium-term period, preparation of a preliminary calender of decisions to be taken for the implementation of the projects recommended, preparation of a preliminary construction schedule, preparation of a preliminary investment program, preparation of a program of necessary engineering works, and performance of study on electricity rates which would adjust existing tariffs to proposed development program of the utility. (HP) [de
2013-04-05
... regarding benefit; and section 771(5A) of the Act regarding specificity. In making these findings, we have... Operations to Paul Piquado, Assistant Secretary for Import Administration, ``Decision Memorandum for... China'' (Preliminary Decision Memorandum), dated currently with this notice, and hereby adopted by this...
Davis, Michael E; Lisowyj, Michal P; Zhou, Lin; Wisecarver, James L; Gulizia, James M; Shostrom, Valerie K; Naud, Nathalie; Corpet, Denis E; Mirvish, Sidney S
2012-01-01
Nitrite-preserved meats (e.g., hot dogs) may help cause colon cancer because they contain N-nitroso compounds. We tested whether purified hot-dog-derived total apparent N-nitroso compounds (ANC) could induce colonic aberrant crypts, which are putative precursors of colon cancer. We purified ANC precursors in hot dogs and nitrosated them to produce ANC. In preliminary tests, CF1 mice received 1 or 3 i.p. injections of 5mg azoxymethane (AOM)/kg. In Experiments 1 and 2, female A/J mice received ANC in diet. In Experiment 1, ANC dose initially dropped sharply because the ANC precursors had mostly decomposed but, later in Experiment 1 and throughout Experiment 2, ANC remained at 85 nmol/g diet. Mice were killed after 8 (AOM tests) or 17–34 (ANC tests) wk. Median numbers of aberrant crypts in the distal 2 cm of the colon for 1 and 3 AOM injections, CF1 controls, ANC (Experiment 1), ANC (Experiment 2),and untreated A/J mice were 31, 74, 12, 20, 12, and 5–6, with P ANC tests. Experiment 2 showed somewhat increased numbers of colonic mucin-depleted foci in the ANC-treated group. We conclude that hot-dog-derived ANC induced significant numbers of aberrant crypts in the mouse colon. PMID:22293095
Preliminary Analysis and Selection of Mooring Solution Candidates
DEFF Research Database (Denmark)
Thomsen, Jonas Bjerg; Delaney, Martin
This report covers a preliminary analysis of mooring solutions candidates for four large floating wave energy converters. The work is part of the EUDP project “Mooring Solutions for Large Wave Energy Converters” and is the outcome of "Work Package 3: Preliminary Analysis". The report further...... compose the "Milestone 4: Report on results of preliminary analysis and selection of final candidates. The report is produced by Aalborg University with input from the partner WECs Floating Power Plant, KNSwing, LEANCON and Wave Dragon. Tension Technology International (TTI) has provided a significant...
Energy Technology Data Exchange (ETDEWEB)
Crabbe, Rory A. [Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7 (Canada); Hill, Kathleen A., E-mail: khill22@uwo.ca [Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7 (Canada)
2010-09-10
Age is a major risk factor for heart disease, and cardiac aging is characterized by elevated mitochondrial reactive oxygen species (ROS) with compromised mitochondrial and nuclear DNA integrity. To assess links between increased ROS levels and mutations, we examined in situ levels of ROS and cII mutation frequency, pattern and spectrum in the heart of harlequin (hq)/Big Blue mice. The hq mouse is a model of premature aging with mitochondrial dysfunction and increased risk of oxidative stress-induced heart disease with the means for in vivo mutation detection. The hq mutation produces a significant downregulation in the X-linked apoptosis-inducing factor gene (Aif) impairing both the antioxidant and oxidative phosphorylation functions of AIF. Brain and skin of hq disease mice have elevated frequencies of point mutations in nuclear DNA and histopathology characterized by cell loss. Reports of associated elevations in ROS in brain and skin have mixed results. Herein, heart in situ ROS levels were elevated in hq disease compared to AIF-proficient mice (p < 0.0001) yet, mutation frequency and pattern were similar in hq disease, hq carrier and AIF-proficient mice. Heart cII mutations were also assessed 15 days following an acute exposure to an exogenous ROS inducer (10 mg paraquat/kg). Acute paraquat exposure with a short mutant manifestation period was insufficient to elevate mutation frequency or alter mutation pattern in the post-mitotic heart tissue of AIF-proficient mice. Paraquat induction of ROS requires mitochondrial complex I and thus is likely compromised in hq mice. Results of this preliminary survey and the context of recent literature suggest that determining causal links between AIF deficiency and the premature aging phenotypes of specific tissues is better addressed with assay of mitochondrial ROS and large-scale changes in mitochondrial DNA in specific cell types.
International Nuclear Information System (INIS)
Crabbe, Rory A.; Hill, Kathleen A.
2010-01-01
Age is a major risk factor for heart disease, and cardiac aging is characterized by elevated mitochondrial reactive oxygen species (ROS) with compromised mitochondrial and nuclear DNA integrity. To assess links between increased ROS levels and mutations, we examined in situ levels of ROS and cII mutation frequency, pattern and spectrum in the heart of harlequin (hq)/Big Blue mice. The hq mouse is a model of premature aging with mitochondrial dysfunction and increased risk of oxidative stress-induced heart disease with the means for in vivo mutation detection. The hq mutation produces a significant downregulation in the X-linked apoptosis-inducing factor gene (Aif) impairing both the antioxidant and oxidative phosphorylation functions of AIF. Brain and skin of hq disease mice have elevated frequencies of point mutations in nuclear DNA and histopathology characterized by cell loss. Reports of associated elevations in ROS in brain and skin have mixed results. Herein, heart in situ ROS levels were elevated in hq disease compared to AIF-proficient mice (p < 0.0001) yet, mutation frequency and pattern were similar in hq disease, hq carrier and AIF-proficient mice. Heart cII mutations were also assessed 15 days following an acute exposure to an exogenous ROS inducer (10 mg paraquat/kg). Acute paraquat exposure with a short mutant manifestation period was insufficient to elevate mutation frequency or alter mutation pattern in the post-mitotic heart tissue of AIF-proficient mice. Paraquat induction of ROS requires mitochondrial complex I and thus is likely compromised in hq mice. Results of this preliminary survey and the context of recent literature suggest that determining causal links between AIF deficiency and the premature aging phenotypes of specific tissues is better addressed with assay of mitochondrial ROS and large-scale changes in mitochondrial DNA in specific cell types.
The Mice Drawer System Tissue Sharing Program (MDS-TSP)
Biticchi, Roberta; Cancedda, Ranieri; Cilli, Michele; Cotronei, Vittorio; Costa, Delfina; Liu, Yi; Piccardi, Federica; Pignataro, Salvatore; Ruggiu, Alessandra; Tasso, Roberta; Tavella, Sara
Several organs and apparatus are affected by weightless conditions and in particular by the weightless experienced during space flights. Therefore space missions are good opportunities to investigate in a whole organism the controlling cellular and molecular mechanisms. For this type of studies mice represent an excellent animal model for several reasons: reduced body size, relatively short time needed to reach adulthood, availability of strains with different genetic background and of different transgenic lines, etc. In line with the International Space Station (ISS) development, the Italian Space Agency (ASI) contracted Thales Alenia Space Italia, the largest Italian aerospace industry, to design and build a spaceflight payload for rodent research on ISS, the Mouse Drawer System (MDS -see abstract P. Cipparelli et al.). This payload meets NIH guideline for several physical parameters to maintain 6 animals in good health conditions in a space environment. Given the interest of our laboratory in the microgravity induced skeleton alterations, we focused our attention on transgenic mice over-expressing pleiotrophin (PTN) under the control of the human bone specific osteocalcin promoter. This protein is a heparin-binding cytokine with different functions. PTN is expressed by the cells in an early differentiation stage and is upregulated in tissue injury and wound repair. PTN is specifically involved in bone formation, neurite outgrowth and angiogenesis. As PTN-transgenic mice show an increased bone mass and mineralization, we decided to use this mouse model in the flight experiment and to study its potential role in counteracting bone loss in microgravity. Not all mouse strains are equally suitable for flight. After preliminary tests in the MDS breadboard at our animal facility on the behavior of different mouse strains, PTN-transgenic mice originally obtained in the BDF strain were backcrossed in the C57Bl/J10 strain before being used in this study. In order to
Space reactor preliminary mechanical design
International Nuclear Information System (INIS)
Meier, K.L.
1983-01-01
An analysis was performed on the SABRE reactor space power system to determine the effect of the number and size of heat pipes on the design parameters of the nuclear subsystem. Small numbers of thin walled heat pipes were found to give a lower subsystem mass, but excessive fuel swelling resulted. The SP-100 preliminary design uses 120 heat pipes because of acceptable fuel swelling and a minimum nuclear subsystem mass of 1875 kg. Salient features of the reactor preliminary design are: individual fuel modules, ZrO 2 block core mounts, bolted collar fuel module restraints, and a BeO central plug
Zinc metabolism in genetically obese mice
International Nuclear Information System (INIS)
Kennedy, M.L.; Failla, M.L.
1986-01-01
Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from lean controls. In the present studies the absorption, retention and tissue distribution of zinc was compared in obese (ob/ob) and lean (+/?) C57BL/6J mice. When administered 0.1 and 1 umole 65 Zn by stomach tube and killed after 4 h, fasted 10 week old obese mice had 2.7 and 2.2 times more radioactivity in their carcasses, respectively, than age-matched lean mice. Higher levels of 65 Zn were also present in the intestinal mucosa of obese mice. To eliminate possible differences in the effects of fasting and gastric emptying rates between the phenotypes, zinc absorption and retention were determined according to the method of Heth and Hoekstra. Analysis of data revealed that obese and lean mice absorbed 43 and 18% of the oral dose, respectively. Also, the rate of 65 Zn excretion between 2 and 6 days post-treatment was similar for obese and lean mice. After 6 days obese mice had significantly lower levels of radioisotope in skin, muscle plus bone, spleen and testes and higher levels of 65 Zn in liver, small intestine and adipose tissue compared to tissues from lean mice. These results demonstrate increased absorption, altered tissue distribution and similar excretion of zinc in ob/ob mice
Preliminary results on the implantation of a laboratory for the measurement of natural radiocarbon
International Nuclear Information System (INIS)
Pessenda, C.L.R.; Pessenda, R.; Nascimento Filho, V.F. do; Victoria, R.L.; Matsui, E.
1990-01-01
Though the project 'Amazonia I', activity 'Paleoclimatology', sub-project 'hydrologic cycle', the Centro de Energia Nuclear da Agricultura (CENA) from Universidade de Sao Paulo has received recently, from Atomic Energy International Agency a research apparatus for the tranformation of carbon from benzene samples and a liquid scintillator spectrometer of low background, for the detection of natural radiocarbon. In the production of 3ml of benzene, synthetized from oxalic acid P.A. and calcium carbonate P.A., it was obtained a performance of more than 80%; preliminary results were also obtained for shell and coal samples. For the detection of radiocarbon, after optimization of the spectral region, and selection of samples, it was seen that the efficiency of the spectrometer was of the order of 55%, with a base counting rate of 1,3 cmp. The age limit, under the actual operation conditions was 41.600 years 95% (2σ) and 36.700 years for 99% (3σ) considering a time counting of 1000 minutes for the sample and the bacground radiation. (A.C.A.S.) [pt
Energy Technology Data Exchange (ETDEWEB)
Boriano, A. [Dipartimento di Fisica Sperimentale e INFN, Via P.Giuria 1, 1-10125 Turin (Italy); Bourhaleb, F. [Fondazione TERA, Via Puccini 1, 1-28100 Novara (Italy); Cirio, R. [Dipartimento di Fisica Sperimentale e INFN, Via P.Giuria 1, 1-10125 Turin (Italy)] (and others)
2006-01-15
Preliminary results are presented from a test of a parallel plate ionization chamber with the anode segmented in strips (MOPI) to be used as a beam monitor for therapeutical treatments on the 62 MeV proton beam line of the INFN-LNS Superconducting Cyclotron. Ocular pathologies have been treated at the Catana facility since March 2002. The detector, placed downstream of the patient collimator, will allow the measurement of the relevant beam diagnostic parameters during treatment such as integrated beam fluence, for dose determination; the beam baricentre, width and asymmetry will be obtained from the fluence profile sampled with a resolution of about 100 Urn at a rate up to 1 kHz with no dead time. In this test, carried out at LNS, the detector has been exposed to different beam shapes and the integrated fluence derived by the measured beam profiles has been compared with that obtained with other dosimeters normally used for treatment. The skewness of the beam profile has been measured and shown to be suitable to on-line check variations of the beam shape.
International Nuclear Information System (INIS)
Boriano, A.; Bourhaleb, F.; Cirio, R.
2006-01-01
Preliminary results are presented from a test of a parallel plate ionization chamber with the anode segmented in strips (MOPI) to be used as a beam monitor for therapeutical treatments on the 62 MeV proton beam line of the INFN-LNS Superconducting Cyclotron. Ocular pathologies have been treated at the Catana facility since March 2002. The detector, placed downstream of the patient collimator, will allow the measurement of the relevant beam diagnostic parameters during treatment such as integrated beam fluence, for dose determination; the beam baricentre, width and asymmetry will be obtained from the fluence profile sampled with a resolution of about 100 Urn at a rate up to 1 kHz with no dead time. In this test, carried out at LNS, the detector has been exposed to different beam shapes and the integrated fluence derived by the measured beam profiles has been compared with that obtained with other dosimeters normally used for treatment. The skewness of the beam profile has been measured and shown to be suitable to on-line check variations of the beam shape
Boriano, A.; Bourhaleb, F.; Cirio, R.; Cirrone, G. A. P.; Cuttone, G.; Donetti, M.; Garelli, E.; Giordanengo, S.; Luparia, A.; Marchette, F.; Peroni, C.; Raffaele, L.; Sabini, M. G.; Valastro, L.
2006-01-01
Preliminary results are presented from a test of a parallel plate ionization chamber with the anode segmented in strips (MOPI) to be used as a beam monitor for therapeutical treatments on the 62 MeV proton beam line of the INFN-LNS Superconducting Cyclotron. Ocular pathologies have been treated at the Catana facility since March 2002. The detector, placed downstream of the patient collimator, will allow the measurement of the relevant beam diagnostic parameters during treatment such as integrated beam fluence, for dose determination; the beam baricentre, width and asymmetry will be obtained from the fluence profile sampled with a resolution of about 100 Urn at a rate up to 1 kHz with no dead time. In this test, carried out at LNS, the detector has been exposed to different beam shapes and the integrated fluence derived by the measured beam profiles has been compared with that obtained with other dosimeters normally used for treatment. The skewness of the beam profile has been measured and shown to be suitable to on-line check variations of the beam shape.
Preliminary results from direct-to-facility vaccine deliveries in Kano, Nigeria.
Aina, Muyi; Igbokwe, Uchenna; Jegede, Leke; Fagge, Rabiu; Thompson, Adam; Mahmoud, Nasir
2017-04-19
As part of its vaccine supply chain redesign efforts, Kano state now pushes vaccines directly from 6 state stores to primary health centers equipped with solar refrigerators. Our objective is to describe preliminary results from the first 20months of Kano's direct vaccine delivery operations. This is a retrospective review of Kano's direct vaccine delivery program. We analyzed trends in health facility vaccine stock levels, and examined the relationship between stock-out rates and each of cascade vaccine deliveries and timeliness of deliveries. Analysis of vaccination trends was based on administrative data from 27 sentinel health facilities. Costs for both the in-sourced and out-sourced approaches were estimated using a bottoms-up model-based approach. Overall stock adequacy increased from 54% in the first delivery cycle to 68% by cycle 33. Conversely, stock-out rates decreased from 41% to 10% over the same period. Similar trends were observed in the out-sourced and in-sourced programs. Stock-out rates rose incrementally with increasing number of cascade facilities, and delays in vaccine deliveries correlated strongly with stock-out rates. Recognizing that stock availability is one of many factors contributing to vaccinations, we nonetheless compared pre- and post- direct deliveries vaccinations in sentinel facilities, and found statistically significant upward trends for 4 out of 6 antigens. 1 antigen (measles) showed an upward trend that was not statistically significant. Hepatitis b vaccinations declined during the period. Overall, there appeared to be a one-year lag between commencement of direct deliveries and the increase in number of vaccinations. Weighted average cost per delivery is US$29.8 and cost per child immunized is US$0.7 per year. Direct vaccine delivery to health facilities in Kano, through a streamlined architecture, has resulted in decreased stock-outs and improved stock adequacy. Concurrent operation of insourced and outsourced programs has
Directory of Open Access Journals (Sweden)
Kimmo Kalevi Kahilainen
Full Text Available Adaptive radiation is considered an important mechanism for the development of new species, but very little is known about the role of thermal adaptation during this process. Such adaptation should be especially important in poikilothermic animals that are often subjected to pronounced seasonal temperature variation that directly affects metabolic function. We conducted a preliminary study of individual lifetime thermal habitat use and respiration rates of four whitefish (Coregonus lavaretus (L. morphs (two pelagic, one littoral and one profundal using stable carbon and oxygen isotope values of otolith carbonate. These morphs, two of which utilized pelagic habitats, one littoral and one profundal recently diverged via adaptive radiation to exploit different major niches in a deep and thermally stratified subarctic lake. We found evidence that the morphs used different thermal niches. The profundal morph had the most distinct thermal niche and consistently occupied the coldest thermal habitat of the lake, whereas differences were less pronounced among the shallow water pelagic and littoral morphs. Our results indicated ontogenetic shifts in thermal niches: juveniles of all whitefish morphs inhabited warmer ambient temperatures than adults. According to sampling of the otolith nucleus, hatching temperatures were higher for benthic compared to pelagic morphs. Estimated respiration rate was the lowest for benthivorous profundal morph, contrasting with the higher values estimated for the other morphs that inhabited shallower and warmer water. These preliminary results suggest that physiological adaptation to different thermal habitats shown by the sympatric morphs may play a significant role in maintaining or strengthening niche segregation and divergence in life-history traits, potentially contributing to reproductive isolation and incipient speciation.
The genetic variability of the Podolica cattle breed from the Gargano area. Preliminary results
Directory of Open Access Journals (Sweden)
Dario Cianci
2010-01-01
Full Text Available The Podolica cattle breed is autochthonous of Southern Italy and denoted by its particular rusticity. This study presents the preliminary results of the genetic characterization of the Podolica breed using DNA STR markers. A total of 20 microsatellite loci were analysed in 79 individuals reared in the Gargano area. Number of polymorphisms, allele fre- quencies, deviations from Hardy-Weinberg proportions, linkage disequilibrium between loci and genetic similarities between animals were calculated. The results showed a high deficiency of heterozygotes, the observed mean of het- erozygosis being 0.449, whereas the expected mean was 0.766. Many markers showed also deviations from the Hardy- Weinberg proportions and significant linkage disequilibrium between loci. However the genetic similarity within the pop- ulation was low (0.281 and the average number of alleles per locus was high (10, representing a high genetic vari- ability. In order to explain these results, a stratification of the breed in sub-populations with a high interior genetic homo- geneity but markedly differentiated one from each other could be hypothesized; this situation probably derived from non- random mating within each herd (consanguinity and from the lack of exchange of genetic material between the herds. A further study is needed on a wider sample and extending the analysis to FAO-ISAG microsatellite panel in order to con- firm this hypothesis. This could eventually provide the information necessary for the correct management of the repro- ductive schemes and for genomic traceability of meat production.
Life span and tumorigenesis in mice exposed to continuous low dose-rate gamma-rays
International Nuclear Information System (INIS)
Tanaka, Satoshi; Braga-Tanaka III, Ignacia; Takabatake, Takashi; Ichinohe, Kazuaki; Tanaka, Kimio; Matsumoto, Tsuneya; Sato, Fumiaki
2004-01-01
Two experiments were conducted to evaluate late biological effects of chronic low dose-rate radiation. 1: Late effects of chronic low dose-rate gamma-ray irradiation on SPF mice, using life span and pathological changes as parameters. Continuous irradiation for approximately 400 days was performed using 137 Cs gamma-rays at dose-rates of 20 mGy/day, 1 mGy/day and 0.05 mGy/day with accumulated doses equivalent to 8000 mGy, 400 mGy and 20 mGy, respectively. All mice were kept until their natural death. Statistical analyses show that the life spans of the both sexes irradiated at 20 mGy/day (p<0.0001) and of females irradiated at 1 mGy/day (p<0.05) were significantly shorter than those of the control group. There was no evidence of lengthened life span in mice continuously exposed to very low dose-rates of gama-rays. Pathodological examinations showed that the most frequently observed lethal neoplasms in males were malignant lymphomas, liver, lung, and soft tissue neoplasms, whereas, in females, malignant lymphomas and soft tissue neoplasms were common. No significant difference in the causes of death and mortality rates between groups. Hematopoietic neoplasms (malignant lymphoma and myeloid leukemia), liver, lung and soft tissue neoplasms, showed a tendency to appear at a younger age in both sexes irradiated at 20 mGy/day. Experiment 2: effects on the progeny of chronic low dose-rate gamma-ray irradiated SPF mice: preliminary study. No significant difference was observed between non-irradiated group and irradiated group with regards to litter size, sex ratio and causes of death in F1 and F2 mice. (author)
Translocation of 11C from leaves of Helianthus: preliminary results
International Nuclear Information System (INIS)
Fensom, D.S.; Aikman, D.; Scobie, J.; Drinkwater, A.; Ledingham, K.W.O.
1977-01-01
11 C fed to leaves as 11 CO 2 was used to study the dynamics of short-term translocation of photosynthate in Helianthus. As in 14 C studies small amounts of tracer were often detected in the stem close to the fed leaf in th first 5 min, followed by a larger mass flow after 15 min. The speed of mass flow of tracer movement was calculated to be 60 to 400 cm.h -1 depending on the method of calculation. There was no evidence in the premass flow for discrete spots along the stem or petiole where tracer accumulated. Neither was there firm evidence for pulses of tracer moving steadily forward, but there were point fluctuations of greater variability than would be expected by chance alone, which suggest the possibility of aberrations of movement superimposed on the mass flow. Details of these aberrations could not be assessed with certainty from these preliminary experiments owing to the rather low tracer activity. The translocation profiles were sensitive to the prior light conditioning of the plant and above all to chilling. In Helianthus the latter produced temporary restrictions in translocation which lasted for some 10-12 min. (author)
Miguel Sarmiento, Aguasanta; Bonnail, Estefanía; Nieto Liñán, José Miguel; Valls Casillas, Tomás Ángel del
2017-01-01
The current work reports on the preliminary results of a toxicity test using screening experiments to check the efficiency of an innovative passive treatment plant designed for acid mine drainage purification. Bioassays took place with water samples before and after the treatment system and in the river, once treated water is discharged. Due to the high toxicity of the water collected at the mouth of the mine (before the treatment plant), the bioassay was designed and developed with respect t...
Energy Technology Data Exchange (ETDEWEB)
Taouli, Bachir [Icahn School of Medicine at Mount Sinai, Department of Radiology, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Hoshida, Yujin; Chen, Xintong; Sun, Xiaochen; Kojima, Kensuke; Toffanin, Sara; Hirschfield, Hadassa [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); Kakite, Suguru [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Tottori University, Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Yonago City (Japan); Tan, Poh Seng [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); National University Health System, Division of Gastroenterology and Hepatology, University Medicine Cluster, Singapore (Singapore); Kihira, Shingo [Icahn School of Medicine at Mount Sinai, Department of Radiology, New York, NY (United States); Fiel, M.I. [Icahn School of Medicine at Mount Sinai, Department of Pathology, New York, NY (United States); Wagner, Mathilde [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, New York, NY (United States); Sorbonne Universites, UPMC, Department of Radiology, Hopital Pitie-Salpetriere, Paris (France); Llovet, Josep M. [Icahn School of Medicine at Mount Sinai, Liver Cancer Program, Tisch Cancer Institute, New York, NY (United States); Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, Department of Medicine, New York, NY (United States); Universitat de Barcelona, HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group Institut d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona (Spain); Institucio Catalana de Recerca i Estudis Avancats, Barcelona (Spain)
2017-11-15
In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis. Thirty-nine HCC tumours (mean size 5.7 ± 3.2 cm) were assessed. Significant positive associations were observed between certain imaging traits and gene signatures of aggressive HCC phenotype (G3-Boyault, Proliferation-Chiang profiles, CK19-Villanueva, S1/S2-Hoshida) with odds ratios ranging from 4.44-12.73 (P <0.045). Infiltrative pattern at imaging was significantly associated with signatures of microvascular invasion and aggressive phenotype. Significant but weak associations were also observed between each enhancement ratio and tumour-to-liver contrast ratios and certain gene expression profiles. This preliminary study demonstrates a correlation between phenotypic imaging traits with gene signatures of aggressive HCC, which warrants further prospective validation to establish imaging-based surrogate markers of molecular phenotypes in HCC. (orig.)
International Nuclear Information System (INIS)
Taouli, Bachir; Hoshida, Yujin; Chen, Xintong; Sun, Xiaochen; Kojima, Kensuke; Toffanin, Sara; Hirschfield, Hadassa; Kakite, Suguru; Tan, Poh Seng; Kihira, Shingo; Fiel, M.I.; Wagner, Mathilde; Llovet, Josep M.
2017-01-01
In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis. Thirty-nine HCC tumours (mean size 5.7 ± 3.2 cm) were assessed. Significant positive associations were observed between certain imaging traits and gene signatures of aggressive HCC phenotype (G3-Boyault, Proliferation-Chiang profiles, CK19-Villanueva, S1/S2-Hoshida) with odds ratios ranging from 4.44-12.73 (P <0.045). Infiltrative pattern at imaging was significantly associated with signatures of microvascular invasion and aggressive phenotype. Significant but weak associations were also observed between each enhancement ratio and tumour-to-liver contrast ratios and certain gene expression profiles. This preliminary study demonstrates a correlation between phenotypic imaging traits with gene signatures of aggressive HCC, which warrants further prospective validation to establish imaging-based surrogate markers of molecular phenotypes in HCC. (orig.)
Lipid metabolism and body composition in Gclm(-/-) mice
Energy Technology Data Exchange (ETDEWEB)
Kendig, Eric L. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Chen, Ying [Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Aurora, CO 80045 (United States); Krishan, Mansi; Johansson, Elisabet; Schneider, Scott N. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Genter, Mary Beth; Nebert, Daniel W. [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Shertzer, Howard G., E-mail: shertzhg@ucmail.uc.edu [Department of Environmental Health, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States); Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267 (United States)
2011-12-15
In humans and experimental animals, high fat diets (HFD) are associated with risk factors for metabolic diseases, such as excessive weight gain and adiposity, insulin resistance and fatty liver. Mice lacking the glutamate-cysteine ligase modifier subunit gene (Gclm(-/-)) and deficient in glutathione (GSH), are resistant to HFD-mediated weight gain. Herein, we evaluated Gclm-associated regulation of energy metabolism, oxidative stress, and glucose and lipid homeostasis. C57BL/6J Gclm(-/-) mice and littermate wild-type (WT) controls received a normal diet or an HFD for 11 weeks. HFD-fed Gclm(-/-) mice did not display a decreased respiratory quotient, suggesting that they are unable to process lipid for metabolism. Although dietary energy consumption and intestinal lipid absorption were unchanged in Gclm(-/-) mice, feeding these mice an HFD did not produce excess body weight nor fat storage. Gclm(-/-) mice displayed higher basal metabolic rates resulting from higher activities of liver mitochondrial NADH-CoQ oxidoreductase, thus elevating respiration. Although Gclm(-/-) mice exhibited strong systemic and hepatic oxidative stress responses, HFD did not promote glucose intolerance or insulin resistance. Furthermore, HFD-fed Gclm(-/-) mice did not develop fatty liver, likely resulting from very low expression levels of genes encoding lipid metabolizing enzymes. We conclude that Gclm is involved in the regulation of basal metabolic rate and the metabolism of dietary lipid. Although Gclm(-/-) mice display a strong oxidative stress response, they are protected from HFD-induced excessive weight gain and adipose deposition, insulin resistance and steatosis. -- Highlights: Black-Right-Pointing-Pointer A high fat diet does not produce body weight and fat gain in Gclm(-/-) mice. Black-Right-Pointing-Pointer A high fat diet does not induce steatosis or insulin resistance in Gclm(-/-) mice. Black-Right-Pointing-Pointer Gclm(-/-) mice have high basal metabolism and mitochondrial
Preliminary results from the Arecibo Heating Experiment (HEX): HF to GNSS
Jackson-Booth, N.; Penney, R.; Bernhardt, P. A.; Martin, P. L.; Buckland, R.; Morton-Orr, T.; Nossa, E.; Buckland, R.
2017-12-01
The ionosphere is subject to many solar and terrestrial influences that can generate disturbances, causing degradation to modern communication and navigational systems. Whilst the disturbances are normally caused by natural phenomena such as hurricanes, earthquakes and solar storms; they can also be generated by artificially modifying the ionosphere. Artificial Ionospheric Modification (AIM) attempts to alter a small region of the ionosphere in order to perturb the RF propagation environment. This can be achieved through injecting the ionosphere with aerosols, chemicals or radio signals. The effects of any such modification can be detected through the deployment of sensors, including ground based high-frequency (HF) sounders and dual-band Global Navigation Satellite System (GNSS) receivers. HF sounders allow measurements of the bottom-side of the ionosphere. GNSS receivers offer a convenient means of obtaining information about the ionosphere, including ionospheric disturbances through changes in the derived total electron content information. The Heating EXperiment (HEX), which took place in March and May 2017, was designed to further our understanding of the phenomena caused by artificially heating a small region of the ionosphere, using the Arecibo facility in Puerto Rico. This was achieved by utilizing a HF measurement experiment spread between Texas and Trinidad and the deployment of a small scale travelling ionospheric disturbance (TID) network near the heater. The TID network comprised three GNSS receivers along baselines of approximately 4 km, located 20 km north of the heater. This paper presents preliminary results from the HEX campaign, including evidence of heating-induced disturbances enhancing propagation between Virginia and Trinidad. The implications of generated irregularities on GNSS will also be discussed.
Lee, Yong Sun; Yi, Jung-Sun; Seo, Souk Jin; Kim, Joo Hwan; Jung, Mi-Sook; Seo, Im-Kwon; Ahn, Ilyoung; Ko, Kyungyuk; Kim, Tae Sung; Lim, Kyung Min; Sohn, Soojung
2017-02-01
The local lymph node assay using 5-bromo-2-deoxyuridine (BrdU) with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA that is used to identify skin sensitizers by counting BrdU-incorporated lymph node cells (LNCs) with flow cytometry. Unlike other LLNA methods (OECD TG 429, 442A and 442B) in which the CBA/J mouse strain is used, LLNA: BrdU-FCM was originally designed to be compatible with BALB/c, a mouse strain that is more widely used in many countries. To justify the substitution of CBA/J for BALB/c, the equivalence of the test results between two strains shall be established prior to the official implementation of LLNA: BrdU-FCM. This study aims to compare the test results of LLNA: BrdU-FCM produced in BALB/c mice with those in CBA/J mice for 18 reference substances, including 13 sensitizers and 5 non-sensitizers, listed in OECD Test Guideline 429. Based on the LLNA: BrdU-FCM test procedure, we selected an appropriate solvent and then performed preliminary tests to determine the non-irritating dose ranges for the main study, which revealed the difference in the irritation responses to 8 of the 18 chemicals between the two strains. In the main study, we measured the changes in the number of total LNCs, which indicated differences in the responses to test chemicals between the two strains. However, the stimulation index obtained with the counts of BrdU-incorporated LNCs with 7-AAD using flow cytometry yielded comparable results and 100% concordance between the BALB/c and CBA/J mouse strains was achieved, suggesting that the performance of LLNA: BrdU-FCM using BALB/c mice was equivalent to that with CBA/J mice. Copyright © 2016 Elsevier Inc. All rights reserved.
Neuro-Cognitive Intervention for Working Memory: Preliminary Results and Future Directions.
Bree, Kathleen D; Beljan, Paul
2016-01-01
Definitions of working memory identify it as a function of the executive function system in which an individual maintains two or more pieces of information in mind and uses that information simultaneously for some purpose. In academics, working memory is necessary for a variety of functions, including attending to the information one's teacher presents and then using that information simultaneously for problem solving. Research indicates difficulties with working memory are observed in children with mathematics learning disorder (MLD) and reading disorders (RD). To improve working memory and other executive function difficulties, and as an alternative to medication treatments for attention and executive function disorders, the Motor Cognition(2)® (MC(2)®)program was developed. Preliminary research on this program indicates statistically significant improvements in working memory, mathematics, and nonsense word decoding for reading. Further research on the MC(2)® program and its impact on working memory, as well as other areas of executive functioning, is warranted.
Directory of Open Access Journals (Sweden)
Teresa Souto
2013-01-01
Full Text Available BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia, using 3D avatars and virtual reality. METHODS: Presentation of 3D avatars which reproduce images developed with the FaceGen® software and integrated in a three-dimensional virtual environment. Each avatar was presented to a group of 12 patients with schizophrenia and a reference group of 12 subjects without psychiatric pathology. RESULTS: The results show that the facial emotions of happiness and anger are better recognized by both groups and that the major difficulties arise in fear and disgust recognition. Frontal alpha electroencephalography variations were found during the presentation of anger and disgust stimuli among patients with schizophrenia. DISCUSSION: The developed program evaluation module can be of surplus value both for patient and therapist, providing the task execution in a non anxiogenic environment, however similar to the actual experience.
Directory of Open Access Journals (Sweden)
Natalia Nadrowska
2017-05-01
Full Text Available Background The article describes construct of family resilience with the main focus on the model Walsh. The aim of this article is to present preliminary results: adaptation, reliability, statistical analyses of the Family Resilience Assessment Scale (FRAS for the Polish population. Participants and procedure Participants (n = 329, aged 18-35, completed experimental Polish version of the FRAS (SPR – Skala Prężności Rodzinnej. In the procedure of adaptation, scale was translated and modified into Polish. Scale consists of the following subscales: Family Communication and Problem Solving, Utilizing Social and Economic Resources, Maintaining a Positive Outlook, Family Connectedness, Family Spirituality and Ability to Make Meaning of Adversity. Results The reliability of the experimental Polish version of the FRAS for the entire scale and five subscales are satisfactory. Only subscale Ability to Make Meaning of Adversity obtained reliability of less than 0.7. Taking into account the diversity of gender and declaring the passage through the difficult events were observed significant differences in the three scales: Family Communication and Problem Solving, Family Connectedness, Ability to Make Meaning of Adversity and total scale of FRAS. Conclusions The work on the questionnaire is still in progress and the results presented here should be considered as preliminary. In the next steps, the number of men should be increased in order to perform confirmatory factor analysis. Future studies should take into account a number of factors and contexts (e.g. family structure, social and cultural context and the type of stressful event.
Chronotoxicity of glufosinate ammonium in mice.
Yoshiyama, Y; Kobayashi, T; Kondo, R; Tomonaga, F; Ohwada, T
1995-02-01
The effect of a circadian-stage dependent dosing schedule on the toxicity of glufosinate was studied in mice. Male ICR mice were housed in a standardized 12:12 light:dark cycle for 3 w. Each animal was given 1500 or 3000 mg glufosinate/kg po. A highly significant circadian rhythm occurred in the resulting mortality, with the highest mortality from doses given during the light phase and the lowest from doses administered during the dark phase. The circadian-stage dependent dosing schedule had a marked influence on the pattern of acute glufosinate toxicity in mice.
Effect of Yikangning on immunological function in mice
International Nuclear Information System (INIS)
Hou Fangyu; Xu Xiaoyi; Shi Yulu; Sheng Xuecheng; Zhao Liyan
2001-01-01
Objective: To investigate the effect of Yikangning oral liquid on immunological function in mice. Methods: 3 H-TdR incorporation was used to detect the lymphocyte transformation rate for Con A and LPS. Results: The drug increased the lymphocyte transformation rate in mice with lowed immunological function. Conclusion: Yikangning enhances immunological function in mice with lowered immunological function
2013-06-28
... withdrawal from warehouse, for consumption, in accordance with 19 CFR 351.212(c)(2).\\3\\ \\3\\ See Preliminary... shipments of the subject merchandise entered, or withdrawn from warehouse, for consumption on or after the... Import & Export Trading 4 Anhui Honghui Import & Export Trade Co., Ltd. 5 Anhui Cereals Oils and...
International Nuclear Information System (INIS)
Bodkha, Kapil; Pilkhwal, D.S.; Jana, S.S.; Vijayan, P.K.
2016-01-01
Natural circulation systems find extensive applications in industrial engineering systems. One of the applications is in nuclear reactor where the decay heat is removed by natural circulation of the fluid under off-normal conditions. The upcoming reactor designs make use of natural circulation in order to remove the heat from core under normal operating conditions also. These reactors employ multiple vertical fuel channels with provision of on-power refueling/defueling. Natural circulation systems are relatively simple, safe and reliable when compared to forced circulation systems. However, natural circulation systems are prone to encounter flow instabilities which are highly undesirable for various reasons. Presence of parallel channels under natural circulation makes the system more complicated. To examine the behavior of parallel channel system, studies were carried out for single-phase natural circulation flow in a multiple vertical channel system. The objective of the present work is to study the flow behavior of the parallel heated channel system under natural circulation for different operating conditions. Steady state and transient studies have been carried out in a parallel channel natural circulation system with three heated channels. The paper brings out the details of the system considered, different cases analyzed and preliminary results of studies carried out on a single-phase parallel channel system.
Preliminary Results of Nuclear Fluorescence Imaging of Alpha and Beta Emitting Sources
International Nuclear Information System (INIS)
Feener, Jessica S.; Charlton, William S.
2013-06-01
The preliminary results from a series of nuclear fluorescence imaging experiments using a variety of radioactive sources and shielding are given. These experiments were done as part of a proof of concept to determine if nuclear fluorescence imaging could be used as a safeguards measurements tool or for nuclear warhead verification for nuclear arms control treaties such as the New Strategic Arms Reduction Treaty and the Fissile Material Cut-Off Treaty. An off-the-shelf Princeton Instruments charged coupled device camera system was used to image the emission of fluorescence photons from the de-excitation of nitrogen molecules in air that have been excited by ionizing radiation. The fluorescence emissions are primarily in the near ultraviolet range; between the wavelengths of 300 and 400 nm. Fluorescent imaging techniques are currently being investigated in a number of applications. A French research team has successfully demonstrated this concept for remote imaging of alpha contamination. It has also been shown that the phenomenon can be seen through translucent materials and that alpha radiation can be seen in the presence of large gamma backgrounds. Additionally, fluorescence telescopes and satellites utilize the de-excitation of nitrogen molecules to observe cosmic ray showers in the atmosphere. In cosmic ray shower detection, electrons are the main contributor to the excitation of the of nitrogen molecules in air. The experiments presented in this paper were designed to determine if the imaging system could observe beta emitting sources, differentiate between beta emitters and alpha emitting materials such as uranium oxide and uranium metal, and to further investigate the phenomenon through translucent and non-translucent materials. The initial results show that differentiation can be made between beta and alpha emitting sources and that the device can observe the phenomenon through very thin non-transparent material. Additionally, information is given on the
Wang, Xing-He; Li, Chun-Yan; Muhammad, Ishfaq; Zhang, Xiu-Ying
2016-06-01
In this study, we investigated the correlation between the serum fatty acid composition and hepatic steatosis, inflammation, hepatocellular ballooning scores, and liver fatty acids composition in mice fed a high-fat diet. Livers were collected for non-alcoholic fatty liver disease score analysis. Fatty acid compositions were analysed by gas chromatography. Correlations were determined by Pearson correlation coefficient. Exposed to a high-fat diet, mice developed fatty liver disease with varying severity without fibrosis. The serum fatty acid variation became more severe with prolonged exposure to a high-fat diet. This variation also correlated significantly with the variation in livers, with the types of fatty acids corresponding to liver steatosis, inflammation, and hepatocellular ballooning scores. Results of this study lead to the following hypothesis: the extent of serum fatty acid variation may be a preliminary biomarker of fatty liver disease caused by high-fat intake. Copyright © 2016. Published by Elsevier B.V.
Christensen, Karen E; Mikael, Leonie G; Leung, Kit-Yi; Lévesque, Nancy; Deng, Liyuan; Wu, Qing; Malysheva, Olga V; Best, Ana; Caudill, Marie A; Greene, Nicholas D E; Rozen, Rima
2015-03-01
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. Our goal was to investigate the impact of high folic acid intake on liver disease and methyl metabolism. Folic acid-supplemented diet (FASD, 10-fold higher than recommended) and control diet were fed to male Mthfr(+/+) and Mthfr(+/-) mice for 6 mo to assess gene-nutrient interactions. Liver pathology, folate and choline metabolites, and gene expression in folate and lipid pathways were examined. Liver and spleen weights were higher and hematologic profiles were altered in FASD-fed mice. Liver histology revealed unusually large, degenerating cells in FASD Mthfr(+/-) mice, consistent with nonalcoholic fatty liver disease. High folic acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced in FASD-fed mice. 5-Methyltetrahydrofolate, SAM, and SAM/S-adenosylhomocysteine ratios were lower in FASD and Mthfr(+/-) livers. Choline metabolites, including phosphatidylcholine, were reduced due to genotype and/or diet in an attempt to restore methylation capacity through choline/betaine-dependent SAM synthesis. Expression changes in genes of one-carbon and lipid metabolism were particularly significant in FASD Mthfr(+/-) mice. The latter changes, which included higher nuclear sterol regulatory element-binding protein 1, higher Srepb2 messenger RNA (mRNA), lower farnesoid X receptor (Nr1h4) mRNA, and lower Cyp7a1 mRNA, would lead to greater lipogenesis and reduced cholesterol catabolism into bile. We suggest that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTHFR deficiency. This deficiency results in hepatocyte degeneration, suggesting a 2-hit mechanism whereby mutant hepatocytes cannot
Preliminary results of the Vega-1 and Vega-2 space probes rendezvous with the Halley comet
International Nuclear Information System (INIS)
Anon.
1986-01-01
Preliminary results of the Halley comet investigation using the Vega-1 and Vega-2 space probes which passed on the 6th and 9th of March, 1986 the comet nucleus at a distance of 9000 and 8200 respectively, are presented. The comet nucleus appeared to be one of the darkest bodies of the Solar system: its albedo is just about 4%. The IR spectrum analysis has shown, that water and carbon dioxide appear to be the main components of the comet material. Mass analysis points out to the presence in the comet dust of iron, oxygen and silicon. It is ascertained, that about 30 t of water vapors and about 5-10 t of dust are evaporated from the comet nucleus surface in one second. Solar wind interaction with the comet streched atmosphere was investigated
Energy Technology Data Exchange (ETDEWEB)
Yoon, Kwon-Ha; Park, Sung Hoon; Kim, Chang Guhn; Won, Jong Jin; Moon, Hyung Bae [Wonkwang Univ. School of Medicine, Iksan (Korea, Republic of); Yu, Dae Yeul [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)
2000-11-01
To determine the value of high resolution ultrasonography (US) for the detection of hepatocellular carcinoma in the HBx transgenic mice. Forty-two HBx transgenic mice aged 8-20 (mean, 14) months underwent high-resolution ultrasound using a 10-12 MHz linear transducer. US findings indication the presence or absence, number, size and echogenicity of each hepatic tumor were analyzed, and in addition, color or power Doppler US was used to analyse tumoral vascularity. In each animal, sacrificed less than five hours after US examination, sonographic and pathologic findings were correlated. On gross pathologic examination, 20 hepatocellular carcinomas measuring 1.5-15 (mean, 4.7) mm in diameter were found in 16 mice; US revealed that 17 of the tumors were homogeneous hypoechoic nodules. With regard to tumor detection, sensitivity was 85%, specificity 96%, positive predictive value 0.944, negative predictive value 0.897, and overall accuracy 90%. Doppler US revealed that in three nodules, intratumoral vessels were present. In the other 26 mice, gross examination showed that no mass was present; microscopically, however, four nodules measuring 0.3-1.2 mm were found in four of these animals. Tumoral vascularity detected by color Doppler US corresponded to the intratumoral vessel within the nodules. One peritoneal nodule, confirmed as a metastatic tumor, was found at the greater omentum. In HBx transgenic mice, high-resolution US is valuable for the detection of hepatocellular carcinoma.
In Situ Vitrification preliminary results from the first large-scale radioactive test
International Nuclear Information System (INIS)
Buelt, J.L.; Westsik, J.H.
1988-01-01
The first large-scale radioactive test (LSRT) of In Situ Vitrification (ISV) has been completed. In Situ Vitrification is a process whereby joule heating immobilizes contaminated soil in place by converting it to a durable glass and crystalline waste form. The LSRT was conducted at an actual transuranic contaminated soil site on the Department of Energy's Hanford Site. The test had two objectives: 1) determine large-scale processing performance and 2) produce a waste form that can be fully evaluated as a potential technique for the final disposal of transuranic-contaminated soil sites at Hanford. This accomplishment has provided technical data to evaluate the ISV process for its potential in the final disposition of transuranic-contaminated soil sites at Hanford. The LSRT was completed in June 1987 after 295 hours of operation and 460 MWh of electrical energy dissipated to the molten soil. This resulted in a minimum of a 450-t block of vitrified soil extending to a depth of 7.3m (24 ft). The primary contaminants vitrified during the demonstration were Pu and Am transuranics, but also included up to 26,000 ppm fluorides. Preliminary data show that their retention in the vitrified product exceeded predictions meaning that fewer contaminants needed to be removed from the gaseous effluents by the processing equipment. The gaseous effluents were contained and treated throughout the run; that is, no radioactive or hazardous chemical releases were detected
Reconstructing Holocene climate using a climate model: Model strategy and preliminary results
Haberkorn, K.; Blender, R.; Lunkeit, F.; Fraedrich, K.
2009-04-01
An Earth system model of intermediate complexity (Planet Simulator; PlaSim) is used to reconstruct Holocene climate based on proxy data. The Planet Simulator is a user friendly general circulation model (GCM) suitable for palaeoclimate research. Its easy handling and the modular structure allow for fast and problem dependent simulations. The spectral model is based on the moist primitive equations conserving momentum, mass, energy and moisture. Besides the atmospheric part, a mixed layer-ocean with sea ice and a land surface with biosphere are included. The present-day climate of PlaSim, based on an AMIP II control-run (T21/10L resolution), shows reasonable agreement with ERA-40 reanalysis data. Combining PlaSim with a socio-technological model (GLUES; DFG priority project INTERDYNAMIK) provides improved knowledge on the shift from hunting-gathering to agropastoral subsistence societies. This is achieved by a data assimilation approach, incorporating proxy time series into PlaSim to initialize palaeoclimate simulations during the Holocene. For this, the following strategy is applied: The sensitivities of the terrestrial PlaSim climate are determined with respect to sea surface temperature (SST) anomalies. Here, the focus is the impact of regionally varying SST both in the tropics and the Northern Hemisphere mid-latitudes. The inverse of these sensitivities is used to determine the SST conditions necessary for the nudging of land and coastal proxy climates. Preliminary results indicate the potential, the uncertainty and the limitations of the method.
Absorbed dose to mice in prolonged irradiation by low-dose rate ionizing radiation
Energy Technology Data Exchange (ETDEWEB)
Shiragai, Akihiro [National Inst. of Radiological Sciences, Chiba (Japan); Saitou, Mikio; Kudo, Iwao [and others
2000-07-01
In this paper, the dose absorbed by mice was evaluated as a preliminary study of the late effects of prolonged continuous irradiation of mice with low-dose rate ionizing radiation. Eight-week-old male and female SPF C3H/HeN mice in three irradiation rooms were exposed to irradiation at 8000, 400, and 20 mGy, respectively, using a {sup 137}Cs {gamma}-source. Nine racks were arranged in a circle approximately 2.5 m from the source in each room, and 10 cages were arranged on the 4 shelves of each rack. Dose distributions, such as in air at the source level, in the three rooms were estimated by using ionization chambers, and the absorbed dose distributions in the room and relative dose distributions in the cages in relation to the distance of the cage center were examined. The mean abdomen doses of the mice measured by TLD were compared with the absorbed doses in the cages. The absorbed dose distributions showed not only inverse-inverse-square-law behavior with distance from the source, but geometric symmetry in every room. The inherent scattering and absorption in each room are responsible for such behavior and asymmetry. Comparison of relative dose distributions revealed cage positions that are not suitable for experiments with high precision doses, but all positions can be used for prolonged continuous irradiation experiments if the position of the cages is rotated regularly. The mean abdomen doses of the mice were similar in each cage. The mean abdomen doses of the mice and the absorbed doses in a cage were almost the same in all cages. Except for errors concerning the positions of the racks and cages, the uncertainties in the exposure doses were estimated to be about {+-}12% for 8000 mGy group, 17% for 400 mGy group, and 35% for 20 mGy group. (K.H.)
Energy Technology Data Exchange (ETDEWEB)
Takemura, Takayo; Yoshida, Yuichi [Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Osaka (Japan); Kiso, Shinichi, E-mail: kiso@gh.med.osaka-u.ac.jp [Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Osaka (Japan); Kizu, Takashi; Furuta, Kunimaro; Ezaki, Hisao; Hamano, Mina; Egawa, Mayumi; Chatani, Norihiro; Kamada, Yoshihiro [Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Osaka (Japan); Imai, Yasuharu [Department of Gastroenterology, Ikeda Municipal Hospital, Ikeda, Osaka (Japan); Higashiyama, Shigeki [Department of Biochemistry and Molecular Genetics, Ehime University, Graduate School of Medicine and Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center (ProMRes), Ehime University, Shitsukawa, Toon, Ehime (Japan); Iwamoto, Ryo; Mekada, Eisuke [Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka (Japan); Takehara, Tetsuo [Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, Osaka (Japan)
2013-07-26
Highlights: •HB-EGF expression was increased during the development of liver fibrosis. •Conditional HB-EGF knockout mouse showed enhanced experimental liver fibrosis. •HB-EGF antagonized TGF-β-induced activation of hepatic stellate cells. •We report a possible protective role of HB-EGF in cholestatic liver fibrosis. -- Abstract: Our aims were to evaluate the involvement of heparin-binding EGF-like growth factor (HB-EGF) in liver fibrogenesis of humans and mice and to elucidate the effect of HB-EGF deficiency on cholestatic liver fibrosis using conditional HB-EGF knockout (KO) mice. We first demonstrated that gene expression of HB-EGF had a positive significant correlation with that of collagen in human fibrotic livers, and was increased in bile duct ligation (BDL)-induced fibrotic livers in mouse. We then generated conditional HB-EGF knockout (KO) mice using the interferon inducible Mx-1 promoter driven Cre recombinase transgene and wild type (WT) and KO mice were subjected to BDL. After BDL, KO mice exhibited enhanced liver fibrosis with increased expression of collagen, compared with WT mice. Finally, we used mouse hepatic stellate cells (HSCs) to examine the role of HB-EGF in the activation of these cells and showed that HB-EGF antagonized TGF-β-induced gene expression of collagen in mouse primary HSCs. Interestingly, HB-EGF did not prevent the TGF-β-induced nuclear accumulation of Smad3, but did lead to stabilization of the Smad transcriptional co-repressor TG-interacting factor. In conclusion, our data suggest a possible protective role of HB-EGF in cholestatic liver fibrosis.
International Nuclear Information System (INIS)
Takemura, Takayo; Yoshida, Yuichi; Kiso, Shinichi; Kizu, Takashi; Furuta, Kunimaro; Ezaki, Hisao; Hamano, Mina; Egawa, Mayumi; Chatani, Norihiro; Kamada, Yoshihiro; Imai, Yasuharu; Higashiyama, Shigeki; Iwamoto, Ryo; Mekada, Eisuke; Takehara, Tetsuo
2013-01-01
Highlights: •HB-EGF expression was increased during the development of liver fibrosis. •Conditional HB-EGF knockout mouse showed enhanced experimental liver fibrosis. •HB-EGF antagonized TGF-β-induced activation of hepatic stellate cells. •We report a possible protective role of HB-EGF in cholestatic liver fibrosis. -- Abstract: Our aims were to evaluate the involvement of heparin-binding EGF-like growth factor (HB-EGF) in liver fibrogenesis of humans and mice and to elucidate the effect of HB-EGF deficiency on cholestatic liver fibrosis using conditional HB-EGF knockout (KO) mice. We first demonstrated that gene expression of HB-EGF had a positive significant correlation with that of collagen in human fibrotic livers, and was increased in bile duct ligation (BDL)-induced fibrotic livers in mouse. We then generated conditional HB-EGF knockout (KO) mice using the interferon inducible Mx-1 promoter driven Cre recombinase transgene and wild type (WT) and KO mice were subjected to BDL. After BDL, KO mice exhibited enhanced liver fibrosis with increased expression of collagen, compared with WT mice. Finally, we used mouse hepatic stellate cells (HSCs) to examine the role of HB-EGF in the activation of these cells and showed that HB-EGF antagonized TGF-β-induced gene expression of collagen in mouse primary HSCs. Interestingly, HB-EGF did not prevent the TGF-β-induced nuclear accumulation of Smad3, but did lead to stabilization of the Smad transcriptional co-repressor TG-interacting factor. In conclusion, our data suggest a possible protective role of HB-EGF in cholestatic liver fibrosis
Some Preliminary Scientific Results of Chang'E-3 Mission
Zou, Y.; Li, W.; Zheng, Y.; Li, H.
2015-12-01
Chang'E-3 mission is the main task of Phase two of China Lunar Exploration Program (CLEP), and also is Chinese first probe of landing, working and roving on the moon. Chang'E-3 craft composed of a lander and a rover, and each of them carry four scientific payloads respectively. The landing site of Chang'E-3 was located at 44.12 degrees north latitude and 19.51 degrees west longitude, where is in the northern part of Imbrium Which the distance in its west direction from the landing site of former Soviet probe Luna-17 is about 400 km, and about 780km far from the landing site of Appolo-17 in its southeast direction. Unfortunately, after a series of scientific tests and exploration on the surface of the moon, the motor controller communication of the rover emerged a breakdown on January 16, 2014, which leaded the four payloads onboard the rover can't obtain data anymore. However, we have received some interesting scientific data which have been studied by Chinese scientists. During the landing process of Chang'E-3, the Landing camera got total 4673 images with the Resolution in millimeters to meters, and the lander and rover took pictures for each other at different point with Topography camera and Panoramic camera. We can find characteristic changes in celestial brightness with time by analyzing image data from Lunar-based Ultraviolet Telescope (LUT) and an unprecedented constraint on water content in the sunlit lunar exosphere seen by LUT). The figure observed by EUV camera (EUVC) shows that there is a transient weak area of the Earth's plasma sphere; This event took place about three hours. The scientists think that it might be related to the change of the particle density of mid-latitude ionosphere. The preliminary spectral and mineralogical results from the landing site are derived according to the data of Visible and Near-infrared Imaging Spectrometer (VNIS). Seven major elements including Mg, Al, Si, K, Ca, Ti and Fe have been identified by the Active Particle
Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.
1987-01-01
Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.
Energy Technology Data Exchange (ETDEWEB)
Czelusniak, C. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Palla, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pisa and Università di Pisa, Largo B. Pontecorvo 3, I-56127 Pisa (Italy); Massi, M. [Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Carraresi, L.; Giuntini, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Re, A.; Lo Giudice, A. [Dipartimento di Fisica, Università di Torino & INFN Sezione di Torino, Via Giuria 1, 10125 Torino (Italy); Pratesi, G. [Museo di Storia Naturale, Università di Firenze, Via G. La Pira 4, 50121 Firenze (Italy); Mazzinghi, A. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Ruberto, C. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Chimica, Università di Firenze, Via della Lastruccia 1, 50019 Sesto Fiorentino, Firenze (Italy); Castelli, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); and others
2016-03-15
This work will present preliminary results concerning the use of time-resolved ion beam induced luminescence applied to provenance studies of lapis lazuli. Measurements were performed at the pulsed beam facility at LABEC laboratory in Florence. Lapis lazuli is a semi-precious gemstone, used as ornament since the early civilizations that can be found in few places on Earth. The importance of this work lies in understanding the origin of various samples of lapis lazuli, from which it may be possible to gain insight into trade routes from ancient times. The samples studied in this work originated from Chile, Afghanistan, Tajikistan, Myanmar, and Siberia. The stones were irradiated with 3 MeV protons and the resulting luminescence was detected by a photomultiplier tube, whose output was acquired using a sampling digitizer VME module (CAEN/V1720). Wavelength discrimination was performed at 430 nm utilizing a range of beam currents. The results showed that, by changing the beam current intensity, one can study different features of lapis lazuli, and this may aid in distinguishing lapis lazuli from different provenances.
International Nuclear Information System (INIS)
Czelusniak, C.; Palla, L.; Massi, M.; Carraresi, L.; Giuntini, L.; Re, A.; Lo Giudice, A.; Pratesi, G.; Mazzinghi, A.; Ruberto, C.; Castelli, L.
2016-01-01
This work will present preliminary results concerning the use of time-resolved ion beam induced luminescence applied to provenance studies of lapis lazuli. Measurements were performed at the pulsed beam facility at LABEC laboratory in Florence. Lapis lazuli is a semi-precious gemstone, used as ornament since the early civilizations that can be found in few places on Earth. The importance of this work lies in understanding the origin of various samples of lapis lazuli, from which it may be possible to gain insight into trade routes from ancient times. The samples studied in this work originated from Chile, Afghanistan, Tajikistan, Myanmar, and Siberia. The stones were irradiated with 3 MeV protons and the resulting luminescence was detected by a photomultiplier tube, whose output was acquired using a sampling digitizer VME module (CAEN/V1720). Wavelength discrimination was performed at 430 nm utilizing a range of beam currents. The results showed that, by changing the beam current intensity, one can study different features of lapis lazuli, and this may aid in distinguishing lapis lazuli from different provenances.
Directory of Open Access Journals (Sweden)
NEIRE M. DE GOUVEIA
2013-09-01
Full Text Available In this study, extracts of plant species from the Cerrado biome were assessed in order to find potential inhibitors of human salivary alpha-amylase. The plants were collected and extracts were obtained from leaves, bark, and roots. We performed a preliminary phytochemical analysis and a screening for salivar alpha-amylase inhibitory activity. Only three botanical families (Sapotaceae, Sapindaceae and Flacourtiaceae and 16 extracts showed a substantial inhibition (>75% of alpha-amylase. The ethanolic extracts of Pouteria ramiflora obtained from stem barks and root barks decreased amylolytic activity above 95% at a final concentration of 20 µg/mL. Thus, adult male Swiss mice were treated orally with P. ramiflora in acute toxicity and glycemic control studies. Daily administration with 25, 50 and 100 mg/kg of aqueous extract of P. ramiflora for eight days can reduce significantly body weight and blood glucose level in mice. These data suggest that the crude polar extract of P. ramiflora decreases salivary amylolytic activity while lowering the blood levels of glucose.
International Nuclear Information System (INIS)
Sun Hanwen; Gong Peijun; Liu Xiuqing; Hong Jun; Xu Dongmei; Zhang Chunfu; Wang Yongxian; Yao Side
2005-01-01
Superparamagnetic poly(acrylamide) magnetic nanogels produced via photochemical method have been developed. After Hoffmann degradation of carbonyl, the nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. And the magnetic nanogels were further modified by methoxy poly(ethylene glycol) (MPEG) for higher dispersibility and stability. The MPEG-modified magnetic nanogels were characterized by X-ray diffraction (XRD), photo correlation spectroscopy (PCS) and scanning electron microscopy (SEM), respectively. The MPEG-modified magnetic nanogels were labeled by 188 Re radiopharmaceuticals and intravenously injected into tails of mice in the presence and absence of a 0.5 T external magnetic field targeted on the bellies. The radioactivity distribution was monitored in vivo. In the absence of magnetic field, the radioactivity was mainly distributed in liver, spleen, kidney, stomach and lung. In the presence of the magnetic field, the radioactivity was mainly accumulated on the targeted point, verifying the magnetically targeted character. (authors)
DEFF Research Database (Denmark)
Raghava, Jayachandra Mitta; Ebdrup, Bjørn Hylsebeck; Nielsen, Mette Ødegaard
hypothalamus separately. All tracking was performed using PROBTRACKX. Results Baseline: Voxel-wise statistics performed on the probabilistic WM fiber maps for whole brain identified deficiencies in patients, showing reduced macro-structural connectivity in: thalamus, putamen, pallidum, hippocampus, forceps......-lwise statistics performed on the probabilistic WM fiber maps for whole brain showed significant interaction, indicating improvement in the connectivity within the patients in Forceps major, right Cingulum (hippocampus), right Anterior thalamic radiation. Conclusions These preliminary results indicate...
Analysis of the Potential Topical Anti-Inflammatory Activity of Averrhoa carambola L. in Mice
Directory of Open Access Journals (Sweden)
Daniela Almeida Cabrini
2011-01-01
Full Text Available Inflammatory skin disorders, such as psoriasis and atopic dermatitis, are very common in the population; however, the treatments currently available are not well tolerated and are often ineffective. Averrhoa carambola L. (Oxalidaceae is an Asian tree that has been used in traditional folk medicine in the treatment of several skin disorders. The present study evaluates the topical anti-inflammatory effects of the crude ethanolic extract of A. carambola leaves, its hexane, ethyl acetate, and butanol fractions and two isolated flavonoids on skin inflammation. Anti-inflammatory activity was measured using a croton oil-induced ear edema model of inflammation in mice. Topically applied ethanolic extract reduced edema in a dose-dependent manner, resulting in a maximum inhibition of 73 ± 3% and an ID50 value of 0.05 (range: 0.02–0.13 mg/ear. Myeloperoxidase (MPO activity was also inhibited by the extract, resulting in a maximum inhibition of 60 ± 6% (0.6 mg/ear. All of the fractions tested caused inhibition of edema formation and of MPO activity. Treatment with the ethyl acetate fraction was the most effective, resulting in inhibition levels of 75 ± 5 and 54 ± 8% for edema formation and MPO activity, respectively. However, treatment of mice with isolated compounds [apigenin-6-C-β-l-fucopyranoside and apigenin-6-C-(2″-O-α-l-rhamnopyranosyl-β-l-fucopyranoside] did not yield successful results. Apigenin-6-C-(2″-O-α-l-rhamnopyranosyl-β-l-fucopyranoside caused only a mild reduction in edema formation (28 ± 11%. Taken together, these preliminary results support the popular use of A. carambola as an anti-inflammatory agent and open up new possibilities for its use in skin disorders.