Sample records for mice coupling coils

  1. Progress on the Coupling Coil for the MICE Channel

    Green, M.A.; Li, D.; Virostek, S.P.; Lau, W.; Witte, H.; Yang,S.Q.; Drumm, P.; Ivanyushenkov, Y.


    This report describes the progress on the coupling magnet for the international Muon Ionization Cooling Experiment (MICE). MICE consists of two cells of a SFOFO cooling channel that is similar to that studied in the level 2 study of a neutrino factory. The MICE RF coupling coil module (RFCC module) consists of a 1.56 m diameter superconducting solenoid, mounted around four cells of conventional 201.25 MHz closed RF cavities. This report discusses the progress that has been made on the superconducting coupling coil that is around the center of the RF coupling module. This report describes the process by which one would cool the coupling coil using a single small 4 K cooler. In addition, the coupling magnet power system and quench protection system are also described.

  2. Design and Construction of a Prototype Solenoid Coil for MICE Coupling Magnets

    Wang, Li; Pan, Heng; Guo, XingLong; Xu, FengYu; Liu, XiaoKun; Wu, Hong; Zheng, ShiXian; Green, Michael A; Li, Derun; Virostek, Steve; Zisman, Michael


    A superconducting coupling solenoid mounted around four conventional RF cavities, which produces up to 2.6 T central magnetic field to keep the muons within the cavities, is to be used for the Muon Ionization Cooling Experiment (MICE). The coupling coil made from copper matrix NbTi conductors is the largest of three types of magnets in MICE both in terms of 1.5 m inner diameter and about 13MJ stored magnetic energy at full operation current of 210A. The stress induced inside the coil assembly during cool down and magnet charging is relatively high. In order to validate the design method and develop the coil winding technique with inside-wound SC splices required for the coupling coil, a prototype coil made from the same conductor and with the same diameter and thickness but only one-fourth long as the coupling coil was designed and fabricated by ICST. The prototype coil was designed to be charged to strain conditions that are equivalent or greater than would be encountered in the coupling coil. This paper presents detailed design of the prototype coil as well as developed coil winding skills. The analyses on stress in the coil assembly and quench process were carried out.

  3. Mechanical Behavior Analysis of a Test Coil for MICE Coupling Solenoid during Quench

    Pan, Heng; Wang, Li; Guo, Xinglong; Wu, Hong; Green, M.A.


    The coupling magnet for the Muon Ionization Cooling Experiment has a self-inductance of 592 H and the magnet stored energy of 13 MJ at a full current of 210 A for the worst operation case of the MICE channel. The high level of stored energy in the magnet can cause high peak temperature during a quench and induce considerable impact of stresses. One test coil was built in order to validate the design method and to practice the stress and strain situation to occur in the coupling coil. In this study, the analysis on stress redistribution during a quench with sub-divided winding was performed. The stress variation may bring about failure of impregnating material such as epoxy resin, which is the curse of a new normal zone arising. Spring models for impregnating epoxy and fiber-glass cloth in the coil were used to evaluate the mechanical disturbance by impregnated materials failure. This paper presents the detailed dynamic stress and stability analysis to assess the stress distribution during the quench process and to check whether the transient loads are acceptable for the magnet.

  4. Quenching in coupled adiabatic coils

    Williams, J.E.C.


    The prediction of the effects of a quench on stress and temperature is an important aspect of the design of superconducting magnets. Of particular interest, and the exclusive topic of this study, is the prediction of the effects of quenching in coupled adiabatic coils, such as the multi-section windings of a high field NMR spectrometer magnet. The predictive methods used here are based on the measurement of the time of propagation of quench between turns. From this measurement an approximate algorithum for the propagation time is used in a code which solves the linear differential equations for the coil currents and calculates the movement of normal zone boundaries and hence the associated winding resistance.

  5. Coupled Coils, Magnets and Lenz's Law

    Thompson, Frank


    Great scientists in the past have experimented with coils and magnets. Here we have a variation where coupling occurs between two coils and the oscillatory motion of two magnets to give somewhat surprising results. (Contains 6 figures and 1 footnote.)

  6. Wireless power transmission applied the mutual coupling between coils

    Furuta, Kenta; Baba, Ryouichi; Shun, Endo; Nunokawa, Kazuki; Takahashi, Wataru; Maruyama, Tamami


    Recently, the studies of wireless power transfer (WPT) to electric vehicles in motion on the snow-piled road have been reported. In WPT by magnetic field resonance method, transmission coefficient S21, which is one of the scattering parameters, from transmission coil to received coil are degraded because of misalignment of transmitting and receiving coil, the distance between these coils, and the effects of the ice and snow. This paper adopts parasitic coil as a solution to improve the reception power in which the parasitic coil is inserted between transmitting and receiving coils. Analysis and experimental results show that parasitic coil could improve the value of S21 by 15 dB using mutual coupling. LED could be light by this solution when the distance between transmitting and receiving coils are 150 mm.

  7. Modeling Endovascular MRI Coil Coupling with Transmit RF Excitation

    Venkateswaran, Madhav; Unal, Orhan; Hurley, Samuel; Samsonov, Alexey; Wang, Peng; Fain, Sean; Kurpad, Krishna


    Objective To model inductive coupling of endovascular coils with transmit RF excitation for selecting coils for MRI-guided interventions. Methods Independent and computationally efficient FEM models are developed for the endovascular coil, cable, transmit excitation and imaging domain. Electromagnetic and circuit solvers are coupled to simulate net B1+ fields and induced currents and voltages. Our models are validated using the Bloch Siegert B1+ mapping sequence for a series-tuned multimode coil, capable of tracking, wireless visualization and high resolution endovascular imaging. Results Validation shows good agreement at 24, 28 and 34 μT background RF excitation within experimental limitations. Quantitative coil performance metrics agree with simulation. A parametric study demonstrates trade off in coil performance metrics when varying number of coil turns. Tracking, imaging and wireless marker multimode coil features and their integration is demonstrated in a pig study. Conclusion Developed models for the multimode coil were successfully validated. Modeling for geometric optimization and coil selection serves as a precursor to time-consuming and expensive experiments. Specific applications demonstrated include parametric optimization, coil selection for a cardiac intervention and an animal imaging experiment. Significance Our modular, adaptable and computationally efficient modeling approach enables rapid comparison, selection and optimization of inductively-coupled coils for MRI-guided interventions. PMID:26960218

  8. MRI surface-coil pair with strong inductive coupling.

    Mett, Richard R; Sidabras, Jason W; Hyde, James S


    A novel inductively coupled coil pair was used to obtain magnetic resonance phantom images. Rationale for using such a structure is described in R. R. Mett et al. [Rev. Sci. Instrum. 87, 084703 (2016)]. The original rationale was to increase the Q-value of a small diameter surface coil in order to achieve dominant loading by the sample. A significant improvement in the vector reception field (VRF) is also seen. The coil assembly consists of a 3-turn 10 mm tall meta-metallic self-resonant spiral (SRS) of inner diameter 10.4 mm and outer diameter 15.1 mm and a single-loop equalization coil of 25 mm diameter and 2 mm tall. The low-frequency parallel mode was used in which the rf currents on each coil produce magnetic fields that add constructively. The SRS coil assembly was fabricated and data were collected using a tissue-equivalent 30% polyacrylamide phantom. The large inductive coupling of the coils produces phase-coherency of the rf currents and magnetic fields. Finite-element simulations indicate that the VRF of the coil pair is about 4.4 times larger than for a single-loop coil of 15 mm diameter. The mutual coupling between coils influences the current ratio between the coils, which in turn influences the VRF and the signal-to-noise ratio (SNR). Data on a tissue-equivalent phantom at 9.4 T show a total SNR increase of 8.8 over the 15 mm loop averaged over a 25 mm depth and diameter. The experimental results are shown to be consistent with the magnetic resonance theory of the emf induced by spins in a coil, the theory of inductively coupled resonant circuits, and the superposition principle. The methods are general for magnetic resonance and other types of signal detection and can be used over a wide range of operating frequencies.

  9. Control of critical coupling in a coiled coaxial cable resonator.

    Huang, Jie; Wei, Tao; Wang, Tao; Fan, Jun; Xiao, Hai


    This paper reports a coiled coaxial cable resonator fabricated by cutting a slot in a spring-like coiled coaxial cable to produce a periodic perturbation. Electromagnetic coupling between two neighboring slots was observed. By manipulating the number of slots, critical coupling of the coiled coaxial cable resonator can be well controlled. An ultrahigh signal-to-noise ratio (over 50 dB) at the resonant frequency band was experimentally achieved from a coiled coaxial cable resonator with 38 turns. A theoretic model is developed to understand the device physics. The proposed device can be potentially used as a high quality and flexibly designed band-stop filter or a sensor in structural health monitoring.

  10. Comparison of Coil Designs for Transcranial Magnetic Stimulation on Mice

    Rastogi, Priyam; Hadimani, Ravi; Jiles, David


    Transcranial magnetic stimulation (TMS) is a non-invasive treatment for neurological disorders using time varying magnetic field. The electric field generated by the time varying magnetic field is used to depolarize the brain neurons which can lead to measurable effects. TMS provides a surgical free method for the treatment of neurological brain disorders like depression, post-traumatic stress disorder, traumatic brain injury and Parkinson's disease. Before using TMS on human subjects, it is appropriate that its effects are verified on animals such as mice. The magnetic field intensity and stimulated region of the brain can be controlled by the shape, position and current in the coils. There are few reports on the designs of the coils for mice. In this paper, different types of coils are developed and compared using an anatomically realistic mouse model derived from MRI images. Parameters such as focality, depth of the stimulation, electric field strength on the scalp and in the deep brain regions, are taken into account. These parameters will help researchers to determine the most suitable coil design according to their need. This should result in improvements in treatment of specific disorders. Carver Charitable Trust.

  11. Graphene-coated coupling coil for AC resistance reduction

    Miller, John M


    At least one graphene layer is formed to laterally surround a tube so that the basal plane of each graphene layer is tangential to the local surface of the tube on which the graphene layer is formed. An electrically conductive path is provided around the tube for providing high conductivity electrical path provided by the basal plane of each graphene layer. The high conductivity path can be employed for high frequency applications such as coupling coils for wireless power transmission to overcome skin depth effects and proximity effects prevalent in high frequency alternating current paths.

  12. Power Loss Analysis and Comparison of Segmented and Unsegmented Energy Coupling Coils for Wireless Energy Transfer.

    Tang, Sai Chun; McDannold, Nathan J


    This paper investigated the power losses of unsegmented and segmented energy coupling coils for wireless energy transfer. Four 30-cm energy coupling coils with different winding separations, conductor cross-sectional areas, and number of turns were developed. The four coils were tested in both unsegmented and segmented configurations. The winding conduction and intrawinding dielectric losses of the coils were evaluated individually based on a well-established lumped circuit model. We found that the intrawinding dielectric loss can be as much as seven times higher than the winding conduction loss at 6.78 MHz when the unsegmented coil is tightly wound. The dielectric loss of an unsegmented coil can be reduced by increasing the winding separation or reducing the number of turns, but the power transfer capability is reduced because of the reduced magnetomotive force. Coil segmentation using resonant capacitors has recently been proposed to significantly reduce the operating voltage of a coil to a safe level in wireless energy transfer for medical implants. Here, we found that it can naturally eliminate the dielectric loss. The coil segmentation method and the power loss analysis used in this paper could be applied to the transmitting, receiving, and resonant coils in two- and four-coil energy transfer systems.

  13. Vehicle to wireless power transfer coupling coil alignment sensor

    Miller, John M.; Chambon, Paul H.; Jones, Perry T.; White, Clifford P.


    A non-contacting position sensing apparatus includes at least one vehicle-mounted receiver coil that is configured to detect a net flux null when the vehicle is optimally aligned relative to the primary coil in the charging device. Each of the at least one vehicle-mounted receiver coil includes a clockwise winding loop and a counterclockwise winding loop that are substantially symmetrically configured and serially connected to each other. When the non-contacting position sensing apparatus is located directly above the primary coil of the charging device, the electromotive forces from the clockwise winding loop and the counterclockwise region cancel out to provide a zero electromotive force, i.e., a zero voltage reading across the coil that includes the clockwise winding loop and the counterclockwise winding loop.

  14. Optically detunable, inductively coupled coil for self-gating in small animal magnetic resonance imaging.

    Korn, Matthias; Umathum, Reiner; Schulz, Jessica; Semmler, Wolfhard; Bock, Michael


    An inductively coupled coil concept is presented, which improves the compensation of physiological motion by the self-gating (SG) technique. The animal is positioned in a conventional volume coil encompassing the whole animal. A small, resonant surface coil (SG-coil) is placed on the thorax so that its sensitive region includes the heart. Via inductive coupling the SG-coil amplifies selectively the MR signal of the beating heart. With an optical detuning mechanism, this coupling can be switched off during acquisition of the MR image information, whereas it is active during SG data sampling to provide the physiological information. In vivo experiments on a mouse show an amplification of the SG signal by at least 40%. Copyright © 2010 Wiley-Liss, Inc.

  15. Analytical Model and Optimized Design of Power Transmitting Coil for Inductively Coupled Endoscope Robot.

    Ke, Quan; Luo, Weijie; Yan, Guozheng; Yang, Kai


    A wireless power transfer system based on the weakly inductive coupling makes it possible to provide the endoscope microrobot (EMR) with infinite power. To facilitate the patients' inspection with the EMR system, the diameter of the transmitting coil is enlarged to 69 cm. Due to the large transmitting range, a high quality factor of the Litz-wire transmitting coil is a necessity to ensure the intensity of magnetic field generated efficiently. Thus, this paper builds an analytical model of the transmitting coil, and then, optimizes the parameters of the coil by enlarging the quality factor. The lumped model of the transmitting coil includes three parameters: ac resistance, self-inductance, and stray capacitance. Based on the exact two-dimension solution, the accurate analytical expression of ac resistance is derived. Several transmitting coils of different specifications are utilized to verify this analytical expression, being in good agreements with the measured results except the coils with a large number of strands. Then, the quality factor of transmitting coils can be well predicted with the available analytical expressions of self- inductance and stray capacitance. Owing to the exact estimation of quality factor, the appropriate coil turns of the transmitting coil is set to 18-40 within the restrictions of transmitting circuit and human tissue issues. To supply enough energy for the next generation of the EMR equipped with a Ø9.5×10.1 mm receiving coil, the coil turns of the transmitting coil is optimally set to 28, which can transfer a maximum power of 750 mW with the remarkable delivering efficiency of 3.55%.

  16. MICE -- Absorber and focus coil safety working group design document: Preliminary design and assessments

    Barr, Giles; Baynham, Elwyn; Black, Edgar; Bradshaw, Tom; Cummings, Mary Anne; Green, Michael A.; Ishimoto, Shigeru; Ivanyushenkov, Yury; Lau, Wing; Zisman, Michael


    A Neutrino Factory based on a muon storage ring is the ultimate tool for studies of neutrino oscillations, including possibly the discovery of leptonic CP violation. it is also the first step toward a muon collider. To develop a stored-muon-beam facility to serve as a Neutrino Factory, it is necessary to ''cool'' a muon beam (decrease its phase-space volume). The short lifetime of the muon, 2.2 {micro}s at rest, eliminates all currently demonstrated cooling techniques and requires that a new, heretofore untried, technique--ionization cooling--be employed. Although ionization cooling of muons has never been demonstrated in practice, it has been shown by end-to-end simulation and design studies to be an important factor both for the performance and for the cost of a Neutrino Factory. This motivates an international program of R and D, including an experimental demonstration at Rutherford Appleton Laboratory (RAL). The aims of the international Muon Ionization Cooling Experiment are: (1) to show that it is possible to design, engineer and build a section of cooling channel capable of giving the desired performance for a Neutrino Factory; and (2) to place it in a muon beam and measure its performance in various modes of operation and beam conditions, thereby investigating the limits and practicality of cooling. The MICE collaboration has designed an experiment in which a section of an ionization cooling channel is exposed to a muon beam. This cooling channel assembles liquid-hydrogen absorbers providing energy loss and high-gradient radio frequency (RF) cavities to re-accelerate the particles, all tightly contained in a magnetic channel. It reduces the beam transverse emittance by > 10% for muon momenta between 140 and 240 MeV/c. The layout of the experiment is shown. They utilize one complete magnetic cell of the cooling channel, comprising three absorber-focus-coil (AFC) modules and two RF-coupling-coil (RFCC) modules. Spectrometers placed before

  17. Analysis and Optimization of Four-Coil Planar Magnetically Coupled Printed Spiral Resonators

    Sadeque Reza Khan


    Full Text Available High-efficiency power transfer at a long distance can be efficiently established using resonance-based wireless techniques. In contrast to the conventional two-coil-based inductive links, this paper presents a magnetically coupled fully planar four-coil printed spiral resonator-based wireless power-transfer system that compensates the adverse effect of low coupling and improves efficiency by using high quality-factor coils. A conformal architecture is adopted to reduce the transmitter and receiver sizes. Both square architecture and circular architectures are analyzed and optimized to provide maximum efficiency at a certain operating distance. Furthermore, their performance is compared on the basis of the power-transfer efficiency and power delivered to the load. Square resonators can produce higher measured power-transfer efficiency (79.8% than circular resonators (78.43% when the distance between the transmitter and receiver coils is 10 mm of air medium at a resonant frequency of 13.56 MHz. On the other hand, circular coils can deliver higher power (443.5 mW to the load than the square coils (396 mW under the same medium properties. The performance of the proposed structures is investigated by simulation using a three-layer human-tissue medium and by experimentation.

  18. Simulation of g factor for size optimization and coupling in phased array coil design


    The effect of geometric parameters of the coil element in an array on signal-to-noise ratio (SNR) and g factor of parallel imaging are analyzed, and the optimal parameters for the maximal SNR and minimal g factor are also given in this paper. In addition, the effects of coupling on SNR and g factor have been analyzed. The test results indicate that g factor for parallel imaging is greatly increased and SNR is decreased for coupling. According to the optimization, a six-channel parallel coil has been designed for torso imaging.

  19. Functional and morphological cardiac magnetic resonance imaging of mice using a cryogenic quadrature radiofrequency coil.

    Babette Wagenhaus

    Full Text Available Cardiac morphology and function assessment by magnetic resonance imaging is of increasing interest for a variety of mouse models in pre-clinical cardiac research, such as myocardial infarction models or myocardial injury/remodeling in genetically or pharmacologically induced hypertension. Signal-to-noise ratio (SNR constraints, however, limit image quality and blood myocardium delineation, which crucially depend on high spatial resolution. Significant gains in SNR with a cryogenically cooled RF probe have been shown for mouse brain MRI, yet the potential of applying cryogenic RF coils for cardiac MR (CMR in mice is, as of yet, untapped. This study examines the feasibility and potential benefits of CMR in mice employing a 400 MHz cryogenic RF surface coil, compared with a conventional mouse heart coil array operating at room temperature. The cryogenic RF coil affords SNR gains of 3.0 to 5.0 versus the conventional approach and hence enables an enhanced spatial resolution. This markedly improved image quality--by better deliniation of myocardial borders and enhanced depiction of papillary muscles and trabeculae--and facilitated a more accurate cardiac chamber quantification, due to reduced intraobserver variability. In summary the use of a cryogenically cooled RF probe represents a valuable means of enhancing the capabilities of CMR of mice.

  20. Theoretical and Experimental Study on Ground Coupled Heat Pump with Vertical Spiral Coil

    李新国; 周倩; 赵军; 朱强; 胡璟


    The numerical simulation study on the temperature distribution of underground field for the ground coupled heat pump (GCHP) with vertical spiral coil was carried out by using finite element. The distribution and recovery of underground field temperature under different operation ratio and the optimal operation ratio were simulated. The performance parameters, i.e. inlet and outlet temperature of the ground spiral coil in heating and cooling modes were tested, the heat extracted or emitted by the heat pump to the ground was calculated, and the coefficients of performance (COP) of GCHP at heating and cooling modes were analyzed.

  1. Geometry Optimization Approaches of Inductively Coupled Printed Spiral Coils for Remote Powering of Implantable Biomedical Sensors

    Sondos Mehri


    Full Text Available Electronic biomedical implantable sensors need power to perform. Among the main reported approaches, inductive link is the most commonly used method for remote powering of such devices. Power efficiency is the most important characteristic to be considered when designing inductive links to transfer energy to implantable biomedical sensors. The maximum power efficiency is obtained for maximum coupling and quality factors of the coils and is generally limited as the coupling between the inductors is usually very small. This paper is dealing with geometry optimization of inductively coupled printed spiral coils for powering a given implantable sensor system. For this aim, Iterative Procedure (IP and Genetic Algorithm (GA analytic based optimization approaches are proposed. Both of these approaches implement simple mathematical models that approximate the coil parameters and the link efficiency values. Using numerical simulations based on Finite Element Method (FEM and with experimental validation, the proposed analytic approaches are shown to have improved accurate performance results in comparison with the obtained performance of a reference design case. The analytical GA and IP optimization methods are also compared to a purely Finite Element Method based on numerical optimization approach (GA-FEM. Numerical and experimental validations confirmed the accuracy and the effectiveness of the analytical optimization approaches to design the optimal coil geometries for the best values of efficiency.

  2. Protective link for superconducting coil

    Umans, Stephen D.


    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  3. Power Transfer Efficiency of Mutually Coupled Coils in an Aluminum AUV Hull


    currently being used by electric buses, trains, and cars as a method for wirelessly charging these vehicles through an air gap [4]. The benefit of...coils and near-field magnetic coupling for power transfer in a system. IPT is currently being used by electric buses, trains, and cars as a method...1899 Nikola Tesla attempted to transmit power without wires. His goal was to transmit 300 kW of power using a 150 kHz carrier wave [7]. Tesla’s

  4. Optimized ground-coupled heat pump system design for northern climate applications. [Including ground coil

    Catan, M.A.; Baxter, V.D.


    This paper addresses the question of the performance of a ground coupled heat pump (GCHP) system with a water - source heat pump package designed expressly for such systems operating in a northern climate. The project objective was to minimize the life-cycle cost of a GCHP system by optimizing the design of both the heat pump package and the ground coil in concert. In order to achieve this objective, a number of modelling tools were developed or modified to analyze the heat pump's performance and cost and the ground coil's performance. The life-cycle cost of a GCHP system (water-source heat pump with a horizontal ground coil) for an 1800 ft/sup 2/ (167 m/sup 2/) house in Pittsburgh, PA, was minimized over a 7 year economic life. Simple payback for the optimized GCHP system, relative to conventional air-source heat pumps, was under 3 years. The water-source heat pump package resulting from this optimization is calculated to cost 21% more than its conventional counterpart with a heating coefficient of performance (COP) about 20% higher, and a cooling COP about 23% higher. In the GCHP system modeled, its annual energy savings are predicted to be about 11% compared to a system designed around the conventional heat pump while having about the same installation cost. The major conclusion of this study is - GCHP system performance improvement can be attained by improving the water-source heat pump package at less cost than by buying more ground coil. The following conclusions were drawn from the steady-state performance optimization results: (1) By adding about $100.00 to the manufacturer's cost off construction, both the heating and cooling COPs can be improved by 20% or more. (2) Cooling COP need not be sacrificed for the sake of heating performance and vice versa. 13 refs., 11 figs., 12 tabs.

  5. An Investigation of Coupling of the Internal Kink Mode to Error Field Correction Coils in Tokamaks

    Lazarus, Edward Alan [ORNL


    The coupling of the internal kink to an external m/=1/1 pertubation if studied for profiles that are known to result in a saturated internal kink in the limit of a cylindrical tokamak. It is found from 3D equilibrium calculations that, for A 30 circular plasmas and A=3 elliptical shapes, this coupling of the boundary perturbation to the internal kink is strong; the amplitude of the m/n=1/1 structure at q=1 is large compared to the amplitude applied at the plasma boundary. It is proposed that this excitation, which could readily be applied with error field correction coils, be explored as a mechanism for controlling sawtooth amplitudes in high performance tokamak discharges. This saturated internal kink, resulting from small field errors in proposed as an explanation for the TEXTOR measurements of q0 and the distinction between sawtooth effects on the q-profile observed in TEXTOR and DIII-D.

  6. A 3-dimensional model for inductively coupled plasma etching reactors: Coil generated plasma asymmetries

    Kushner, M.J.; Collison, W.Z.; Grapperhaus, M.J. [Univ. of Illinois, Urbana, IL (United States). Dept. of Electrical and Computer Engineering


    Inductively Coupled Plasma (ICP) reactors are being developed as high plasma density, low gas pressure sources for etching and deposition of semiconductor materials. In this paper, the authors describe a 3-dimensional, time dependent model for ICP reactors whose intent is to provide an infrastructure to investigate asymmetries in plasma etching and deposition tools. The model is a 3-dimensional extension of a previously described 2-dimensional simulation called the Hybrid Plasma Equipment Model (HPEM). HPEM-3D consists of an electromagnetics module (EMM), a Boltzmann-electron energy module (BEM) and a fluid-chemical kinetics simulation (FKS). The inductively coupled electromagnetic fields are produced by the EMM. Results from HPEM-3D will be discussed for reactors using etching (Cl{sub 2}, BCl{sub 3}) and non-etching (Ar, Ar/N{sub 2}) gas mixtures, and which have geometrical asymmetries such as wafer clamps and load-lock bays. The authors show how details in the design of the coil, such as the value of the termination capacitance or number of turns, lead to azimuthal variations in the inductive electric field.

  7. Coupling analysis of transcutaneous energy transfer coils with planar sandwich structure for a novel artificial anal sphincter

    Lei KE; Guo-zheng YAN; Sheng YAN; Zhi-wu WANG; Da-sheng LIU


    This paper presents a set of analytical expressions used to determine the coupling coefficient between primary and secondary Litz-wire planar coils used in a transcutaneous energy transfer (TET) system. A TET system has been designed to power a novel elastic scaling artificial anal sphincter system (ES-AASS) for treating severe fecal incontinence (FI), a condition that would benefit from an optimized TET. Expressions that describe the geometrical dimension dependence of self- and mutual inductances of planar coils on a ferrite substrate are provided. The effects of ferrite substrate conductivity, relative permeability, and geometrical dimensions are also considered. To verify these expressions, mutual coupling between planar coils is computed by 3D finite element analysis (FEA), and the proposed expressions show good agreement with numerical results. Different types of planar coils are fabricated with or without ferrite substrate. Measured results for each of the cases are compared with theoretical predictions and FEA solutions. The theoretical results and FEA results are in good agreement with the experimental data.

  8. Multiphysics Integrated Coupling Environment (MICE) User Manual

    Varija Agarwal; Donna Post Guillen


    The complex, multi-part nature of waste glass melters used in nuclear waste vitrification poses significant modeling challenges. The focus of this project has been to couple a 1D MATLAB model of the cold cap region within a melter with a 3D STAR-CCM+ model of the melter itself. The Multiphysics Integrated Coupling Environment (MICE) has been developed to create a cohesive simulation of a waste glass melter that accurately represents the cold cap. The one-dimensional mathematical model of the cold cap uses material properties, axial heat, and mass fluxes to obtain a temperature profile for the cold cap, the region where feed-to-glass conversion occurs. The results from Matlab are used to update simulation data in the three-dimensional STAR-CCM+ model so that the cold cap is appropriately incorporated into the 3D simulation. The two processes are linked through ModelCenter integration software using time steps that are specified for each process. Data is to be exchanged circularly between the two models, as the inputs and outputs of each model depend on the other.

  9. Development of double-layer coupled coil for improving S/N in 7 T small-animal MRI.

    Kim, Kyoung-Nam; Seo, Jeung-Hoon; Han, Sang-Doc; Heo, Phil; Im, Geun Ho; Lee, Jung Hee


    The purpose of this study was to develop a new double-layer coupled (DLC) surface radiofrequency (RF) coil using a combination of single-layer planar (SLP) and single-layer circular (SLC) coils, for enhancement of magnetic flux (B1 ) sensitivity and RF penetration in 7 T rat-body magnetic resonance imaging (MRI). The proposed DLC surface coil was fabricated according to an electromagnetic (EM) simulation and validated based on the B1 distribution and bench measurements. The DLC coil performance was quantitatively evaluated based on the signal-to-noise ratio (S/N) and coil-response signal intensity curves in phantom and in vivo rat-body images. In the computational EM calculation and 7 T in vivo experimental results, the DLC surface coil clearly showed an increased S/N and higher RF transmit (B1 (+) ) profiles, compared to those of the SLP and SLC coils. While all surface coils displayed a rapid decrease in the MR signal from the near-coil region to the subject, the results reveal that the DLC coil concept may be used to provide sufficient RF penetration and high S/N and degrees of freedom for use in partial body imaging for 7 T ultra-high-field small-animal MRI.

  10. Basic Analysis of Two-Coils Structure Based on Magnetically-Coupled Resonant Technology for SWIPT Application

    MA Biyun; CHEN Boheng; LI Sumei; WANG Yide; WEI Gang


    The Magnetically-coupled resonant (MCR) technology is exploited in this paper to realize Synchronous wireless information and power transfer (SWIPT) func-tion, which means that the power carriers also transmit information. The circuit structure of SWIPT system is ana-lyzed and the existence of two optimal frequencies in power efficiency under small resistance circumstance is proved. The physical parameters having influences on the two op-timal frequencies are discussed, such as the distance be-tween coils, impedance characteristics of coils and loads. These results provide a way to increase the bandwidth of MCR technology, while maintaining high power efficiency to realize SWIPT function. Simulations and experimental results are presented to verify the feasibility of the pro-posed system and obtained theoretical expressions.

  11. Study of the Effect of Distance and Misalignment between Magnetically Coupled Coils for Wireless Power Transfer in Intraocular Pressure Measurement

    Adrian E. Rendon-Nava


    Full Text Available An analysis of the effect of distance and alignment between two magnetically coupled coils for wireless power transfer in intraocular pressure measurement is presented. For measurement purposes, a system was fabricated consisting of an external device, which is a Maxwell-Wien bridge circuit variation, in charge of transferring energy to a biomedical implant and reading data from it. The biomedical implant is an RLC tank circuit, encapsulated by a polyimide coating. Power transfer was done by magnetic induction coupling method, by placing one of the inductors of the Maxwell-Wien bridge circuit and the inductor of the implant in close proximity. The Maxwell-Wien bridge circuit was biased with a 10 MHz sinusoidal signal. The analysis presented in this paper proves that wireless transmission of power for intraocular pressure measurement is feasible with the measurement system proposed. In order to have a proper inductive coupling link, special care must be taken when placing the two coils in proximity to avoid misalignment between them.

  12. Study of the effect of distance and misalignment between magnetically coupled coils for wireless power transfer in intraocular pressure measurement.

    Rendon-Nava, Adrian E; Díaz-Méndez, J Alejandro; Nino-de-Rivera, Luis; Calleja-Arriaga, Wilfrido; Gil-Carrasco, Felix; Díaz-Alonso, Daniela


    An analysis of the effect of distance and alignment between two magnetically coupled coils for wireless power transfer in intraocular pressure measurement is presented. For measurement purposes, a system was fabricated consisting of an external device, which is a Maxwell-Wien bridge circuit variation, in charge of transferring energy to a biomedical implant and reading data from it. The biomedical implant is an RLC tank circuit, encapsulated by a polyimide coating. Power transfer was done by magnetic induction coupling method, by placing one of the inductors of the Maxwell-Wien bridge circuit and the inductor of the implant in close proximity. The Maxwell-Wien bridge circuit was biased with a 10 MHz sinusoidal signal. The analysis presented in this paper proves that wireless transmission of power for intraocular pressure measurement is feasible with the measurement system proposed. In order to have a proper inductive coupling link, special care must be taken when placing the two coils in proximity to avoid misalignment between them.

  13. Simulation Research of Magnetically-coupled Resonant Wireless Power Transfer System with Single Intermediate Coil Resonator Based on S Parameters Using ANSYS

    Liu Cheng


    Full Text Available ANSYS can be a powerful tool to simulate the process of energy exchange in magnetically-coupled resonant wireless power transfer system. In this work, the MCR-WPT system with single intermediate coil resonator is simulated and researched based on scattering parameters using ANSYS Electromagnetics. The change rule of power transfer efficiency is reflected intuitively through the scattering parameters. A new method of calculating the coupling coefficient is proposed. A cascaded 2-port network model using scattering parameters is adopted to research the efficiency of transmission. By changing the relative position and the number of turns of the intermediate coil, we find some factors affecting the efficiency of transmission. Methods and principles of designing the MCR-WPT system with single intermediate coil resonator are obtained. And these methods have practical value with design and optimization of system efficiency.

  14. An NFC on Two-Coil WPT Link for Implantable Biomedical Sensors under Ultra-Weak Coupling

    Chen Gong


    Full Text Available The inductive link is widely used in implantable biomedical sensor systems to achieve near-field communication (NFC and wireless power transfer (WPT. However, it is tough to achieve reliable NFC on an inductive WPT link when the coupling coefficient is ultra-low (0.01 typically, since the NFC signal (especially for the uplink from the in-body part to the out-body part could be too weak to be detected. Traditional load shift keying (LSK requires strong coupling to pass the load modulation information to the power source. Instead of using LSK, we propose a dual-carrier NFC scheme for the weak-coupled inductive link; using binary phase shift keying (BPSK modulation, its downlink data are modulated on the power carrier (2 MHz, while its uplink data are modulated on another carrier (125 kHz. The two carriers are transferred through the same coil pair. To overcome the strong interference of the power carrier, dedicated circuits are introduced. In addition, to minimize the power transfer efficiency decrease caused by adding NFC, we optimize the inductive link circuit parameters and approach the receiver sensitivity limit. In the prototype experiments, even though the coupling coefficient is as low as 0.008, the in-body transmitter costs only 0.61 mW power carrying 10 kbps of data, and achieves a 1 × 10 - 7 bit error rate under the strong interference of WPT. This dual-carrier NFC scheme could be useful for small-sized implantable biomedical sensor applications.

  15. An NFC on Two-Coil WPT Link for Implantable Biomedical Sensors under Ultra-Weak Coupling.

    Gong, Chen; Liu, Dake; Miao, Zhidong; Wang, Wei; Li, Min


    The inductive link is widely used in implantable biomedical sensor systems to achieve near-field communication (NFC) and wireless power transfer (WPT). However, it is tough to achieve reliable NFC on an inductive WPT link when the coupling coefficient is ultra-low (0.01 typically), since the NFC signal (especially for the uplink from the in-body part to the out-body part) could be too weak to be detected. Traditional load shift keying (LSK) requires strong coupling to pass the load modulation information to the power source. Instead of using LSK, we propose a dual-carrier NFC scheme for the weak-coupled inductive link; using binary phase shift keying (BPSK) modulation, its downlink data are modulated on the power carrier (2 MHz), while its uplink data are modulated on another carrier (125 kHz). The two carriers are transferred through the same coil pair. To overcome the strong interference of the power carrier, dedicated circuits are introduced. In addition, to minimize the power transfer efficiency decrease caused by adding NFC, we optimize the inductive link circuit parameters and approach the receiver sensitivity limit. In the prototype experiments, even though the coupling coefficient is as low as 0.008, the in-body transmitter costs only 0.61 mW power carrying 10 kbps of data, and achieves a 1 × 10 - 7 bit error rate under the strong interference of WPT. This dual-carrier NFC scheme could be useful for small-sized implantable biomedical sensor applications.

  16. Improving the Mass-Limited Performance of Routine NMR Probes using Coupled Coils

    Marsden, Brian; Lim, Victor; Taber, Bob; Zens, Albert


    We report a method to convert, on demand, a general use dual-broadband probe to a high performance mass-limited probe for both high band and low band nuclei. This technology uses magnetic coupling of inductors to achieve this capability. The method offers a cost effective way of increasing the performance of routine NMR probes without having to change probes or increase the overall foot print of the spectrometer.

  17. Bioinspired coupled helical coils for soft tissue engineering of tubular structures - Improved mechanical behavior of tubular collagen type I templates.

    Janke, H P; Bohlin, J; Lomme, R M L M; Mihaila, S M; Hilborn, J; Feitz, W F J; Oosterwijk, E


    The design of constructs for tubular tissue engineering is challenging. Most biomaterials need to be reinforced with supporting structures such as knittings, meshes or electrospun material to comply with the mechanical demands of native tissues. In this study, coupled helical coils (CHCs) were manufactured to mimic collagen fiber orientation as found in nature. Monofilaments of different commercially available biodegradable polymers were wound and subsequently fused, resulting in right-handed and left-handed polymer helices fused together in joints where the filaments cross. CHCs of different polymer composition were tested to determine the tensile strength, strain recovery, hysteresis, compressive strength and degradation of CHCs of different composition. Subsequently, seamless and stable hybrid constructs consisting of PDSII® USP 2-0 CHCs embedded in porous collagen type I were produced. Compared to collagen alone, this hybrid showed superior strain recovery (93.5±0.9% vs 71.1±12.6% in longitudinal direction; 87.1±6.6% vs 57.2±4.6% in circumferential direction) and hysteresis (18.9±2.7% vs 51.1±12.0% in longitudinal direction; 11.5±4.6% vs 46.3±6.3% in circumferential direction). Furthermore, this hybrid construct showed an improved Young's modulus in both longitudinal (0.5±0.1MPavs 0.2±0.1MPa; 2.5-fold) and circumferential (1.65±0.07MPavs (2.9±0.3)×10(-2)MPa; 57-fold) direction, respectively, compared to templates created from collagen alone. Moreover, hybrid template characteristics could be modified by changing the CHC composition and CHCs were produced showing a mechanical behavior similar to the native ureter. CHC-enforced templates, which are easily tunable to meet different demands may be promising for tubular tissue engineering. Most tubular constructs lack sufficient strength and tunability to comply with the mechanical demands of native tissues. Therefore, we embedded coupled helical coils (CHCs) produced from biodegradable polymers - to

  18. Acupuncture upregulates G protein coupled activity in SAMP8 mice.

    Luo, Benhua; Zhao, Lan; Zhang, Xuezhu; Kan, Bohong; Liu, Yunhe; Jia, Yujie; Han, Jingxian; Yu, Jianchun


    Transmembrane and intracellular signal transduction of G protein is closely related to the pathophysiology of Alzheimer's disease (AD). To explore the effects of Sanjiao acupuncture on G protein signal transduction pathways in the pathogenesis of AD. 36 senescence-accelerated (SAM) prone 8 mice were divided into three groups that remained untreated (SAMP8, n=12) or received Sanjiao acupuncture (SAMP8+SA, n=12) or control acupuncture (SAMP8+CA, n=12). An additional control group of SAM resistant 1 mice was included (SAMR1 group, n=12). Morris water maze tests were used to investigate learning and memory abilities. Immunoprecipitation and Western blotting were used to study expression of G protein subunits and their activities in the cortex/hippocampus. Behavioural analysis showed that acupuncture attenuated the severe cognitive deficits observed in untreated/CA-treated SAMP8 mice. The findings of the G protein activation assays via immunoprecipitation and Western blots were that the physiologically coupled activation rate (PCAR) and maximal coupled activation rate (MCAR) of Gαs and Gαi were decreased in the cortex of SAMP8 vs SAMR1 mice. Sanjiao acupuncture induced an upregulation in the PCAR of Gαs and Gαi. In the hippocampus of untreated SAMP8 mice, the PCAR of Gαs and MCAR of both Gαs and Gαi declined, and Sanjiao acupuncture was associated with an upregulation in the MCAR of Gαs and Gαi. There were no significant differences in Gαs and Gαi expression between the groups. Sanjiao acupuncture attenuates cognitive deficits in a mouse model of AD via upregulation of G protein activity and stabilisation of the cellular signal. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

  19. 光纤环圈内部偏振耦合试验研究%Measurement of polarization coupling in fiber gyro coils

    王树宇; 庞璐; 刘军号; 宁鼎


    The polarization coupling point position and coupling intensity in fiber gyro coils was measured by using optical path compensation ability of Michelson interferometer based on white light interferometry.The results show that the polarization coupling in fiber coils increase in the process of winding and encapsulation and the position of the polarization coupling point is distributed by periodicity.And we can reduce the polar-ization coupling by improve the quadruple symmetric winding technology .%基于白光干涉原理,采用麦克尔逊干涉仪补偿光程差的方法,对光纤环圈内部偏振耦合做了试验研究。研究结果表明:光纤环圈绕制过程中,在光纤环圈内部引入了新增的偏振耦合点,且引入的偏振耦合点呈周期性分布;通过改进环圈的绕制工艺,可以很好地抑制新增耦合点的产生。

  20. α/β coiled coils.

    Hartmann, Marcus D; Mendler, Claudia T; Bassler, Jens; Karamichali, Ioanna; Ridderbusch, Oswin; Lupas, Andrei N; Hernandez Alvarez, Birte


    Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail. They do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying heptad repeat of a parallel, trimeric coiled coil. These insertions strain the supercoil to the breaking point, causing the local formation of short β-strands, which move the path of the chain by 120° around the trimer axis. The result is an α/β coiled coil, which retains only one backbone hydrogen bond per repeat unit from the parent coiled coil. Our results show that a substantially novel backbone structure is possible within the allowed regions of the Ramachandran space with only minor mutations to a known fold.

  1. Delivery of AAV2/9-microdystrophin genes incorporating helix 1 of the coiled-coil motif in the C-terminal domain of dystrophin improves muscle pathology and restores the level of α1-syntrophin and α-dystrobrevin in skeletal muscles of mdx mice.

    Koo, Taeyoung; Malerba, Alberto; Athanasopoulos, Takis; Trollet, Capucine; Boldrin, Luisa; Ferry, Arnaud; Popplewell, Linda; Foster, Helen; Foster, Keith; Dickson, George


    Duchenne muscular dystrophy is a severe X-linked inherited muscle wasting disorder caused by mutations in the dystrophin gene. Adeno-associated virus (AAV) vectors have been extensively used to deliver genes efficiently for dystrophin expression in skeletal muscles. To overcome limited packaging capacity of AAV vectors (damage in the mdx mice compared with MD1. These results suggest that the incorporation of helix 1 of the coiled-coil motif in the CT domain of dystrophin to the microdystrophins will substantially improve their efficiency in restoring muscle function in patients with Duchenne muscular dystrophy.

  2. The effects of neutral gas heating on H mode transition and maintenance currents in a 13.56 MHz planar coil inductively coupled plasma reactor

    Jayapalan, Kanesh K.; Chin, Oi-Hoong


    The H mode transition and maintenance currents in a 13.56 MHz laboratory 6 turn planar coil inductively coupled plasma (ICP) reactor are simulated for low pressure argon discharge range of 0.02-0.3 mbar with neutral gas heating and at ambient temperature. An experimentally fitted 3D power evolution plot for 0.02 mbar argon pressure is also shown to visualize the effects of hysteresis in the system. Comparisons between simulation and experimental measurements show good agreement in the pressure range of 0.02-0.3 mbar for transition currents and 0.02-0.1 mbar for maintenance currents only when neutral gas heating is considered. This suggests that neutral gas heating plays a non-negligible role in determining the mode transition points of a rf ICP system.

  3. An Optimal Design of Resonant Coil for Magnetically Coupled Resonant Wireless Power Transfer System%谐振式无线电能传输系统谐振线圈优化设计

    陈逸鹏; 聂一雄


    By the coupled mode theory, the conditions of efficient energy transfer between the wireless power transfer system for transmitting and receiving coils was derived, then the coil of coupled magnetic resonances analyzed using the equivalent circuit model, and the relationship of the transmission efficiency and the coil parameters got by control variable method through MATLAB. It provides the basis for the optimal design of the coupling coil. Finally, optimization of a specific model was introduced in this paper, with the hope that it will help to achieve an efficient and optimized model.%通过耦合模理论推导出无线电能传输系统发射和接收线圈之间实现能量高效转移的条件,利用等效电路模型对磁耦合谐振线圈进行分析,通过MATLAB仿真软件,得出耦合谐振线圈各参数与传输效率的关系.通过对具体模型进行优化,模型效率明显提高,为耦合线圈的优化设计提供依据.

  4. Superconducting coil system and methods of assembling the same

    Rajput-Ghoshal, Renuka; Rochford, James H.; Ghoshal, Probir K.


    A superconducting magnet apparatus is provided. The superconducting magnet apparatus includes a power source configured to generate a current; a first switch coupled in parallel to the power source; a second switch coupled in series to the power source; a coil coupled in parallel to the first switch and the second switch; and a passive quench protection device coupled to the coil and configured to by-pass the current around the coil and to decouple the coil from the power source when the coil experiences a quench.

  5. Coiled-Coil Design: Updated and Upgraded.

    Woolfson, Derek N


    α-Helical coiled coils are ubiquitous protein-folding and protein-interaction domains in which two or more α-helical chains come together to form bundles. Through a combination of bioinformatics analysis of many thousands of natural coiled-coil sequences and structures, plus empirical protein engineering and design studies, there is now a deep understanding of the sequence-to-structure relationships for this class of protein architecture. This has led to considerable success in rational design and what might be termed in biro de novo design of simple coiled coils, which include homo- and hetero-meric parallel dimers, trimers and tetramers. In turn, these provide a toolkit for directing the assembly of both natural proteins and more complex designs in protein engineering, materials science and synthetic biology. Moving on, the increased and improved use of computational design is allowing access to coiled-coil structures that are rare or even not observed in nature, for example α-helical barrels, which comprise five or more α-helices and have central channels into which different functions may be ported. This chapter reviews all of these advances, outlining improvements in our knowledge of the fundamentals of coiled-coil folding and assembly, and highlighting new coiled coil-based materials and applications that this new understanding is opening up. Despite considerable progress, however, challenges remain in coiled-coil design, and the next decade promises to be as productive and exciting as the last.

  6. Designing Stable Antiparallel Coiled Coil Dimers

    曾宪纲; 周海梦


    The history of antiparallel coiled coil dimer design is briefly reviewed and the main principles governing the successful designs are explained. They include analysis of the inter-subunit electrostatic repulsion for determining partners for dimerization and of the buried polar interaction for determining the relative orientation of the partners. A theory is proposed to explain the lack of antiparallel coiled coil homodimers in nature.

  7. Coil Welding Aid

    Wiesenbach, W. T.; Clark, M. C.


    Positioner holds coil inside cylinder during tack welding. Welding aid spaces turns of coil inside cylinder and applies contact pressure while coil is tack-welded to cylinder. Device facilitates fabrication of heat exchangers and other structures by eliminating hand-positioning and clamping of individual coil turns.

  8. Starfire poloidal coil systems

    Evans, K. Jr.; Kim, S.H.; Turner, L.R.; Wang, S.T.


    The poloidal coils for STARFIRE consists of three systems: (1) equilibrium field (EF) coils; (2) ohmic heating (OH) coils; and (3) correction field (CF) coils. The EF coils are superconducting and lie outside the toroidal field (TF) coils. These coils provide the bulk of the equilibrium field necessary to keep the plasma positioned in the vacuum chamber with the desired cross sectional shape and pressure and current distributions. Having these coils outside of the TF coils requires that they have a larger stored energy and larger currents but eases the assembly, maintenance, and reliability of the coils. The STARFIRE OH system is relatively small compared to tokamaks in which the current is entirely ohmically driven. It is designed to provide sufficient flux in the early startup to raise the plasma current to the point (1 to 2 MA) where the rf current drive can take over.

  9. Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice.

    Cool, Steven K; Geers, Bart; Roels, Stefan; Stremersch, Stephan; Vanderperren, Katrien; Saunders, Jimmy H; De Smedt, Stefaan C; Demeester, Joseph; Sanders, Niek N


    Local extravasation and triggered drug delivery by use of ultrasound and microbubbles is a promising strategy to target drugs to their sites of action. In the past we have developed drug loaded microbubbles by coupling drug containing liposomes to the surface of microbubbles. Until now the advantages of this drug loading strategy have only been demonstrated in vitro. Therefore, in this paper, microbubbles with indocyanine green (ICG) containing liposomes at their surface or a mixture of ICG-liposomes and microbubbles was injected intravenously in mice. Immediately after injection the left hind leg was exposed to 1 MHz ultrasound and the ICG deposition was monitored 1, 4 and 7 days post-treatment by in vivo fluorescence imaging. In mice that received the ICG-liposome loaded microbubbles the local ICG deposition was, at each time point, about 2-fold higher than in mice that received ICG-liposomes mixed with microbubbles. We also showed that the perforations in the blood vessels allow the passage of ICG-liposomes up to 5h after microbubble and ultrasound treatment. An increase in tissue temperature to 41°C was observed in all ultrasound treated mice. However, ultrasound tissue heating was excluded to cause the local ICG deposition. We concluded that coupling of drug containing liposomes to microbubbles may increase ultrasound mediated drug delivery in vivo.

  10. Analysis and experimental study of wireless power transfer with HTS coil and copper coil as the intermediate resonators system

    Wang, Xiufang [School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); School of Physics and Technology, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Nie, Xinyi [School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Liang, Yilang [School of Physics and Technology, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Lu, Falong [School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Yan, Zhongming, E-mail: [School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Wang, Yu [School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China)


    Highlights: • We investigated a kind of system architecture with three coils which the repeater is copper coil or HTS coil. • We simulated the different repeater system and obtained the magnetic field distribution at different distance. • We used helical coil instead of pancake coil which does not use capacitors. • HTS intermediate coil has significant effect on improving the transmission efficiency and lengthening transmission distance than copper intermediate coil. - Abstract: Intermediate resonator (repeater) between transmitter and receiver can significantly increase the distance of wireless power transfer (WPT) and the efficiency of wireless power transfer. The wireless power transfer via strongly coupled magnetic resonances with an high temperature superconducting (HTS) coil and copper coil as intermediate resonators was presented in this paper. The electromagnetic experiment system under different conditions with different repeating coils were simulated by finite element software. The spatial distribution patterns of magnetic induction intensity at different distances were plotted. In this paper, we examined transfer characteristics with HTS repeating coil and copper repeating coil at 77 K and 300 K, respectively. Simulation and experimental results show that HTS and copper repeating coil can effectively enhance the space magnetic induction intensity, which has significant effect on improving the transmission efficiency and lengthening transmission distance. We found that the efficiency and the distance of wireless power transfer system with an HTS coil as repeater is much higher by using of copper coil as repeater.

  11. Maximum entropy reconstruction of joint {phi}, {psi}-distribution with a coil-library prior: the backbone conformation of the peptide hormone motilin in aqueous solution from {phi} and {psi}-dependent J-couplings

    Massad, Tariq; Jarvet, Jueri [Stockholm University, Department of Biochemistry and Biophysics (Sweden); Tanner, Risto [National Institute of Chemical Physics and Biophysics (Estonia); Tomson, Katrin; Smirnova, Julia; Palumaa, Peep [Tallinn Technical University, Inst. of Gene Technology (Estonia); Sugai, Mariko; Kohno, Toshiyuki [Mitsubishi Kagaku Institute of Life Sciences (MITILS) (Japan); Vanatalu, Kalju [Tallinn Technical University, Inst. of Gene Technology (Estonia); Damberg, Peter [Stockholm University, Department of Biochemistry and Biophysics (Sweden)], E-mail:


    In this paper, we present a new method for structure determination of flexible 'random-coil' peptides. A numerical method is described, where the experimentally measured {sup 3}J{sup H{sup N}}{sup H{sup {alpha}}} and {sup 3}J{sup H{sup {alpha}}}{sup N{sup I}+1} couplings, which depend on the {phi} and {psi} dihedral angles, are analyzed jointly with the information from a coil-library through a maximum entropy approach. The coil-library is the distribution of dihedral angles found outside the elements of the secondary structure in the high-resolution protein structures. The method results in residue specific joint {phi},{psi}-distribution functions, which are in agreement with the experimental J-couplings and minimally committal to the information in the coil-library. The 22-residue human peptide hormone motilin, uniformly {sup 15}N-labeled was studied. The {sup 3}J{sup H{sup {alpha}}}{sup N{sup I}+1} were measured from the E.COSY pattern in the sequential NOESY cross-peaks. By employing homodecoupling and an in-phase/anti-phase filter, sharp H{sup {alpha}}-resonances (about 5 Hz) were obtained enabling accurate determination of the coupling with minimal spectral overlap. Clear trends in the resulting {phi},{psi}-distribution functions along the sequence are observed, with a nascent helical structure in the central part of the peptide and more extended conformations of the receptor binding N-terminus as the most prominent characteristics. From the {phi},{psi}-distribution functions, the contribution from each residue to the thermodynamic entropy, i.e., the segmental entropies, are calculated and compared to segmental entropies estimated from {sup 15}N-relaxation data. Remarkable agreement between the relaxation and J-couplings based methods is found. Residues belonging to the nascent helix and the C-terminus show segmental entropies, of approximately -20 J K{sup -1} mol{sup -1} and -12 J K{sup -1} mol{sup -1}, respectively, in both series. The agreement

  12. Maximum entropy reconstruction of joint phi, psi-distribution with a coil-library prior: the backbone conformation of the peptide hormone motilin in aqueous solution from phi and psi-dependent J-couplings.

    Massad, Tariq; Jarvet, Jüri; Tanner, Risto; Tomson, Katrin; Smirnova, Julia; Palumaa, Peep; Sugai, Mariko; Kohno, Toshiyuki; Vanatalu, Kalju; Damberg, Peter


    In this paper, we present a new method for structure determination of flexible "random-coil" peptides. A numerical method is described, where the experimentally measured 3J(H(alpha)Nalpha) and [3J(H(alpha)Nalpha+1 couplings, which depend on the phi and psi dihedral angles, are analyzed jointly with the information from a coil-library through a maximum entropy approach. The coil-library is the distribution of dihedral angles found outside the elements of the secondary structure in the high-resolution protein structures. The method results in residue specific joint phi,psi-distribution functions, which are in agreement with the experimental J-couplings and minimally committal to the information in the coil-library. The 22-residue human peptide hormone motilin, uniformly 15N-labeled was studied. The 3J(H(alpha)-N(i+1)) were measured from the E.COSY pattern in the sequential NOESY cross-peaks. By employing homodecoupling and an in-phase/anti-phase filter, sharp H(alpha)-resonances (about 5 Hz) were obtained enabling accurate determination of the coupling with minimal spectral overlap. Clear trends in the resulting phi,psi-distribution functions along the sequence are observed, with a nascent helical structure in the central part of the peptide and more extended conformations of the receptor binding N-terminus as the most prominent characteristics. From the phi,psi-distribution functions, the contribution from each residue to the thermodynamic entropy, i.e., the segmental entropies, are calculated and compared to segmental entropies estimated from 15N-relaxation data. Remarkable agreement between the relaxation and J-couplings based methods is found. Residues belonging to the nascent helix and the C-terminus show segmental entropies, of approximately -20 J K(-1) mol(-1) and -12 J K(-1) mol(-1), respectively, in both series. The agreement between the two estimates of the segmental entropy, the agreement with the observed J-couplings, the agreement with the CD experiments

  13. Downregulation of Rho associated coiled-coil forming protein kinase 1 in the process of delayed myocardialization of cardiac proximal outflow tract septum in connexin 43 knockout mice embryo

    QI Chun-hua; ZHAO Xiao-qing; MA Duan; MA Xiao-jing; ZHOU Guo-min; HUANG Guo-ying


    Background The connexln43 knockout (Cx43 KO) mouse dies at birth with an enlarged conotruncal region, which leads to the obstruction of the right outflow tract (OFT). Since myocardialization of the proximal OFT septum is one of the key events during heart development, we investigated the process in the Cx43 KO embryo hearts. Rho associated coiled-coil forming protein kinase 1 (ROCK1), is a recently found key molecule to regulate the myocardialization of OFT, but its spatiotemporal expression pattern during myocardialization remains unknown. The objective of this study was to investigate the differentially expressed pattern of ROCK1 between Cx43 KO and wild type embryo hearts, and its relationship with the delayed myocardialization in Cx43 KO embryo hearts.Methods Using immunohistochemistry, the processes of myocardiolization were investigated both in Cx43 KO and wild type embryo hearts. The differentially expressed pattern of ROCK1 between Cx43 KO and wildtype embryo hearts was evaluated both at the mRNA and protein level by real-time RT-PCR and immunohistochemistry.Results The expression of α-sarcomeric actin (α-SCA) in the proximal OFT septum of Cx43 KO embryos was delayed. Meanwhile, it was shown that the downregulation of ROCK1 coincided with delayed myocardialization. The expression of ROCK1 protein was mainly limited to the proximal outflow tract septum from embryo day (E) E11.5 to E15.5. Its expression pattern was similar with that of α-SCA. Real-time RT-PCR found that the expression level of Rock-1 mRNA began at a low level on E11.5 and reached peak at E13.5 and E14.5.Conclusions ROCK1 may have an important role in the process of myocardialization of the proximal OFT septum. Downregulation of ROCK1 is likely to contribute to the aberrant myocardialization in Cx43 KO embryo hearts.

  14. 单级感应线圈炮场路耦合运动时步有限元分析%Field Circuit and Movement Coupled Time Stepping Finite Element Analysis on Single-Stage Inductive Coil Gun

    关晓存; 雷彬; 李治源


    基于麦克斯韦方程组,提出了一种适用于单级感应线圈炮的场路耦合运动时步分析方法,对于瞬态涡流场与电路耦合问题,应用了Crank-Nicholson法进行求解;对于运动问题,采用运动坐标系的方法进行求解;电磁力采用了节点力法求解;解决了单级感应线圈炮在脉冲供电时场路耦合分析问题,建立了单级感应线圈炮电磁场-电路-运动系统二维耦合模型。应用上述模型对单级感应线圈炮进行分析,计算结果与实验结果相吻合,验证了该模型的正确性。%Based on Maxwell equation,a time stepping finite element analysis(FEA) model coupled circuit field and movement used in analyzing single-stage inductive coil gun is presented in this paper,which could solve the problem of impulsing power supply in field-circuit coupled FEA.The transient 2D magnetic field circuit coupling problems are solved by the Crank-Nicholson method,and the problems of motion is handled by the moving coordinates.The force is calculated by nodal force method.The paper sets up the 2D transient electromagnetic field-circuit-moving model of single-stage inductive coil gun.The performance of a single-stage inductive coil gun is analyzed using above model.The calculation result is very close to the measure results,which verifies the model accuracy.

  15. Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.

    Remedi, Maria Sara; Nichols, Colin G


    The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.

  16. Hyperinsulinism and Diabetes: Genetic dissection of β-cell metabolism-excitation coupling in mice

    Remedi, Maria Sara; Nichols, Colin G.


    The role of metabolism-excitation coupling in insulin secretion has long been apparent but, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism and excitability in mice has brought the central importance of this pathway into sharp relief in recent years. We focus on these animal studies, and how they not only provide important insights to metabolic and electrical regulation of insulin secretion, but also to downstream consequences of alterations in this pathway, and to the etiology and treatment of insulin-secretion diseases in humans. PMID:19945402

  17. Dual coil ignition system

    Huberts, Garlan J.; Qu, Qiuping; Czekala, Michael Damian


    A dual coil ignition system is provided. The dual coil ignition system includes a first inductive ignition coil including a first primary winding and a first secondary winding, and a second inductive ignition coil including a second primary winding and a second secondary winding, the second secondary winding connected in series to the first secondary winding. The dual coil ignition system further includes a diode network including a first diode and a second diode connected between the first secondary winding and the second secondary winding.

  18. 新型驱动线圈温度场和流场耦合仿真研究%Simulation research on coupled temperature and flow field for new style driven coil

    关晓存; 雷彬; 李治源; 程二威


    Synchronous induction coil gun is one of electromagnetic launchers, an important aspect in electromagnetic emission area at home and abroad, and is also an importance in the beforehand study of the new concept weapons in our country's army. It has good controllability, high emission efficiency, low cost, simple deskbound protection, high safety and so on, so it has a good applied prospect. For driven coil in coilgun, based on flow - solid coupling method, both solid calculation zone and flow calculation zone were coupled, flow - solid conjugate heat transfer mathematical model of drive coil was set up. And using AN-SYS CFX software, temperature distribution of drive coil and cooling system was analysed, and different speed of coolant influenced the temperature distribution of drive coil and cooling system. The results indicate: when the speed of coolant increases, the temperature of drive coil decrease. And from the temperature distribution, the lowest temperature zone is in gateway of coolant; the maximum temperature zone is in exit of coolant.%同步感应线圈炮是线圈型电磁发射器中的一种,是目前国内外电磁发射领域研究中的一个重要方向,也是我军新概念武器预先研究的重点.它具有发射过程可控性好、发射效率高、成本低以及后勤保障简单、安全性高等特点,具有广泛的应用前景.以驱动线圈为研究对象,采用热-流-固耦合的研究方法,将传统的温度场计算方法割裂的固体计算区域和流体计算区域耦合在一起,建立了统一的流固共轭传热数学模型.并且使用了ANSYSCFX计算软件,计算了驱动线圈和冷却系统的温度分布规律,讨论了不同速度的冷却介质对驱动线圈温度的影响.研究表明:随着冷却油进口速度的不断增加,驱动线圈的温升逐渐减少,并且从温度场分布来看,由于冷却油的温度在入口处较低,流速最大,因此最低温度出现在入口处,最高温度出现在出口处.

  19. 基于 Fluent的蛇管换热器耦合传热数值模拟%Numerical Simulation of Coil Heat Exchanger Coupled Heat Transfer Based on Fluent

    房全国; 李家伟; 姜逢章; 刘庆亮; 张志华


    According to the structure and process parameters of the coil heat exchanger in a project , numerical simulation of coil heat exchanger coupled heat transfer is done by using Fluent software, and then velocity, pressure, and temperature distributions of tube and shell sides are obtained.The outlet temperature, pressure drop and heat transfer of the tube and shell sides are calculated, and the simulation results are compared with those of the experi-ence calculation values.The relative errors are 3.0%, 0.1%, 2.4%, 28.0%and 1.2%.Simulation results are reliable, and numerical simulation pro-vides a new approach for the heat transfer area and pressure drop calculation of the coil heat exchanger.%结合某工程项目中蛇管换热器的结构和工艺参数,利用Fluent软件对蛇管换热器进行耦合传热数值模拟,得到管壳程的速度、压力和温度分布信息,计算得出管壳程出口温度、压降和换热量,并将模拟结果与经验计算值进行了比较,相对误差分别为3.0%、0.1%、2.4%、28.0%和1.2%,模拟结果可靠,为蛇管换热器换热面积和压降的校核计算提供了新的方法和途径.

  20. [Development of RF coil of permanent magnet mini-magnetic resonance imager and mouse imaging experiments].

    Hou, Shulian; Xie, Huantong; Chen, Wei; Wang, Guangxin; Zhao, Qiang; Li, Shiyu


    In the development of radio frequency (RF) coils for better quality of the mini-type permanent magnetic resonance imager for using in the small animal imaging, the solenoid RF coil has a special advantage for permanent magnetic system based on analyses of various types.of RF coils. However, it is not satisfied for imaging if the RF coils are directly used. By theoretical analyses of the magnetic field properties produced from the solenoid coil, the research direction was determined by careful studies to raise further the uniformity of the magnetic field coil, receiving coil sensitivity for signals and signal-to-noise ratio (SNR). The method had certain advantages and avoided some shortcomings of the other different coil types, such as, birdcage coil, saddle shaped coil and phased array coil by using the alloy materials (from our own patent). The RF coils were designed, developed and made for keeled applicable to permanent magnet-type magnetic resonance imager, multi-coil combination-type, single-channel overall RF receiving coil, and applied for a patent. Mounted on three instruments (25 mm aperture, with main magnetic field strength of 0.5 T or 1.5 T, and 50 mm aperture, with main magnetic field strength of 0.48 T), we performed experiments with mice, rats, and nude mice bearing tumors. The experimental results indicated that the RF receiving coil was fully applicable to the permanent magnet-type imaging system.

  1. Spaced-based search coil magnetometers

    Hospodarsky, George B.


    Search coil magnetometers are one of the primary tools used to study the magnetic component of low-frequency electromagnetic waves in space. Their relatively small size, mass, and power consumption, coupled with a good frequency range and sensitivity, make them ideal for spaceflight applications. The basic design of a search coil magnetometer consists of many thousands of turns of wire wound on a high permeability core. When a time-varying magnetic field passes through the coil, a time-varying voltage is induced due to Faraday's law of magnetic induction. The output of the coil is usually attached to a preamplifier, which amplifies the induced voltage and conditions the signal for transmission to the main electronics (usually a low-frequency radio receiver). Search coil magnetometers are usually used in conjunction with electric field antenna to measure electromagnetic plasma waves in the frequency range of a few hertz to a few tens of kilohertzs. Search coil magnetometers are used to determine the properties of waves, such as comparing the relative electric and magnetic field amplitudes of the waves, or to investigate wave propagation parameters, such as Poynting flux and wave normal vectors. On a spinning spacecraft, they are also sometimes used to determine the background magnetic field. This paper presents some of the basic design criteria of search coil magnetometers and discusses design characteristics of sensors flown on a number of spacecraft.

  2. Coil system for plasmoid thruster

    Eskridge, Richard H. (Inventor); Lee, Michael H. (Inventor); Martin, Adam K. (Inventor); Fimognari, Peter J. (Inventor)


    A coil system for a plasmoid thruster includes a bias coil, a drive coil and field coils. The bias and drive coils are interleaved with one another as they are helically wound about a conical region. A first field coil defines a first passage at one end of the conical region, and is connected in series with the bias coil. A second field coil defines a second passage at an opposing end of the conical region, and is connected in series with the bias coil.

  3. Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif.

    Nora Céspedes

    Full Text Available Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development. By using bioinformatics algorithms, a total of 50 antigens with α-helical coiled coil motifs orthologous to Plasmodium falciparum were identified in the P. vivax genome. The peptides identified in silico were chemically synthesized; circular dichroism studies indicated partial or high α-helical content. Antigenicity was evaluated using human sera samples from malaria-endemic areas of Colombia and Papua New Guinea. Eight of these fragments were selected and used to assess immunogenicity in BALB/c mice. ELISA assays indicated strong reactivity of serum samples from individuals residing in malaria-endemic regions and sera of immunized mice, with the α-helical coiled coil structures. In addition, ex vivo production of IFN-γ by murine mononuclear cells confirmed the immunogenicity of these structures and the presence of T-cell epitopes in the peptide sequences. Moreover, sera of mice immunized with four of the eight antigens recognized native proteins on blood-stage P. vivax parasites, and antigenic cross-reactivity with three of the peptides was observed when reacted with both the P. falciparum orthologous fragments and whole parasites. Results here point to the α-helical coiled coil peptides as possible P. vivax malaria vaccine candidates as were observed for P. falciparum. Fragments selected here warrant further study in humans and non-human primate models to assess their protective efficacy as single components or assembled as hybrid linear epitopes.

  4. Time evolution of interhemispheric coupling in a model of focal neocortical epilepsy in mice

    Vallone, F.; Vannini, E.; Cintio, A.; Caleo, M.; Di Garbo, A.


    Epilepsy is characterized by substantial network rearrangements leading to spontaneous seizures and little is known on how an epileptogenic focus impacts on neural activity in the contralateral hemisphere. Here, we used a model of unilateral epilepsy induced by injection of the synaptic blocker tetanus neurotoxin (TeNT) in the mouse primary visual cortex (V1). Local field potential (LFP) signals were simultaneously recorded from both hemispheres of each mouse in acute phase (peak of toxin action) and chronic condition (completion of TeNT effects). To characterize the neural electrical activities the corresponding LFP signals were analyzed with several methods of time series analysis. For the epileptic mice, the spectral analysis showed that TeNT determines a power redistribution among the different neurophysiological bands in both acute and chronic phases. Using linear and nonlinear interdependence measures in both time and frequency domains, it was found in the acute phase that TeNT injection promotes a reduction of the interhemispheric coupling for high frequencies (12 -30 Hz) and small time lag (40 ms). On the other hand, the chronic period is characterized by a partial or complete recovery of the interhemispheric interdependence level. Granger causality test and symbolic transfer entropy indicate a greater driving influence of the TeNT-injected side on activity in the contralateral hemisphere in the chronic phase. Lastly, based on experimental observations, we built a computational model of LFPs to investigate the role of the ipsilateral inhibition and exicitatory interhemispheric connections in the dampening of the interhemispheric coupling. The time evolution of the interhemispheric coupling in such a relevant model of epilepsy has been addressed here.

  5. Liquid rope coiling

    N.M. Ribe; M. Habibi; D. Bonn


    A thin stream or rope of viscous fluid falling from a sufficient height onto a surface forms a steadily rotating helical coil. Tabletop laboratory experiments in combination with a numerical model for slender liquid ropes reveal that finite-amplitude coiling can occur in four distinct regimes (visco

  6. Optimal Bitter Coil Solenoid

    Kobelev, V


    Bitter coil is an electromagnet used for the generation of exceptionally strong magnetic fields. The upper bound of magnet flux density is restricted by several factors. One principal restriction is the high stresses due to Lorentz forces in the coil. The Lorentz forces generate the distributed body force, which acts as the pressure of magnetic field. The common radial thickness profile of the Bitter coil is constant. In this paper the possibility of optimization by means of non-constant radial thickness profile of the Bitter coil is studied. The close form expression for optimal thickness profile is obtained. Both designs are compared and the considerable improvement of magnetic flux density is demonstrated. Moreover, the optimal design improves the shape of cooling channels. Namely, the highest cross-section of cooling channel is at the most thermally loaded inner surface of the coil.

  7. Formulation for a practical implementation of electromagnetic induction coils optimized using stream functions

    Reed, Mark A.; Scott, Waymond R.


    Continuous-wave (CW) electromagnetic induction (EMI) systems used for subsurface sensing typically employ separate transmit and receive coils placed in close proximity. The closeness of the coils is desirable for both packaging and object pinpointing; however, the coils must have as little mutual coupling as possible. Otherwise, the signal from the transmit coil will couple into the receive coil, making target detection difficult or impossible. Additionally, mineralized soil can be a significant problem when attempting to detect small amounts of metal because the soil effectively couples the transmit and receive coils. Optimization of wire coils to improve their performance is difficult but can be made possible through a stream-function representation and the use of partially convex forms. Examples of such methods have been presented previously, but these methods did not account for certain practical issues with coil implementation. In this paper, the power constraint introduced into the optimization routine is modified so that it does not penalize areas of high current. It does this by representing the coils as plates carrying surface currents and adjusting the sheet resistance to be inversely proportional to the current, which is a good approximation for a wire-wound coil. Example coils are then optimized for minimum mutual coupling, maximum sensitivity, and minimum soil response at a given height with both the earlier, constant sheet resistance and the new representation. The two sets of coils are compared both to each other and other common coil types to show the method's viability.

  8. Rapid effects of dorsal hippocampal G-protein coupled estrogen receptor on learning in female mice.

    Lymer, Jennifer; Robinson, Alana; Winters, Boyer D; Choleris, Elena


    Through rapid mechanisms of action, estrogens affect learning and memory processes. It has been shown that 17β-estradiol and an Estrogen Receptor (ER) α agonist enhances performance in social recognition, object recognition, and object placement tasks when administered systemically or infused in the dorsal hippocampus. In contrast, systemic and dorsal hippocampal ERβ activation only promote spatial learning. In addition, 17β-estradiol, the ERα and the G-protein coupled estrogen receptor (GPER) agonists increase dendritic spine density in the CA1 hippocampus. Recently, we have shown that selective systemic activation of the GPER also rapidly facilitated social recognition, object recognition, and object placement learning in female mice. Whether activation the GPER specifically in the dorsal hippocampus can also rapidly improve learning and memory prior to acquisition is unknown. Here, we investigated the rapid effects of infusion of the GPER agonist, G-1 (dose: 50nM, 100nM, 200nM), in the dorsal hippocampus on social recognition, object recognition, and object placement learning tasks in home cage. These paradigms were completed within 40min, which is within the range of rapid estrogenic effects. Dorsal hippocampal administration of G-1 improved social (doses: 50nM, 200nM G-1) and object (dose: 200nM G-1) recognition with no effect on object placement. Additionally, when spatial cues were minimized by testing in a Y-apparatus, G-1 administration promoted social (doses: 100nM, 200nM G-1) and object (doses: 50nM, 100nM, 200nM G-1) recognition. Therefore, like ERα, the GPER in the hippocampus appears to be sufficient for the rapid facilitation of social and object recognition in female mice, but not for the rapid facilitation of object placement learning. Thus, the GPER in the dorsal hippocampus is involved in estrogenic mediation of learning and memory and these effects likely occur through rapid signalling mechanisms.

  9. Flow analysis by using solenoid valves for As(III determination in natural waters by an on-line separation and pre-concentration system coupled to a tungsten coil atomizer

    José Y. Neira


    Full Text Available A flow system coupled to a tungsten coil atomizer in an atomic absorption spectrometer (TCA-AAS was developed for As(III determination in waters, by extraction with sodium diethyldithiocarbamate (NaDDTC as complexing agent, and by sorption of the As(III-DDTC complex in a micro-column filled with 5 mg C18 reversed phase (10 µL dry sorbent, followed by elution with ethanol. A complete pre-concentration/elution cycle took 208 s, with 30 s sample load time (1.7 mL and 4 s elution time (71 µL. The interface and software for the synchronous control of two peristaltic pumps (RUN/ STOP, an autosampler arm, seven solenoid valves, one injection valve, the electrothermal atomizer and the spectrometer Read function were constructed. The system was characterized and validated by analytical recovery studies performed both in synthetic solutions and in natural waters. Using a 30 s pre-concentration period, the working curve was linear between 0.25 and 6.0 µg L-1 (r = 0.9976, the retention efficiency was 94±1% (6.0 µg L-1, and the pre-concentration coefficient was 28.9. The characteristic mass was 58 pg, the mean repeatability (expressed as the variation coefficient was 3.4% (n=5, the detection limit was 0.058 µg L-1 (4.1 pg in 71 µL of eluate injected into the coil, and the mean analytical recovery in natural waters was 92.6 ± 9.5 % (n=15. The procedure is simple, economic, less prone to sample loss and contamination and the useful lifetime of the micro-column was between 200-300 pre-concentration cycles.

  10. The Test Principle and Method of Power Wave Trap Coil and Coupling Filter%电力线阻波器、结合滤波器测试原理及方法

    江均; 钱牛牛; 汪池


    电力线阻波器、结合滤波器是电力线载波通道的重要组成部分,对其特性参数的准确测量是保证电力载波通信正常工作、保证电力系统正常运行的重要保障.本文分析了测试装置的特点,提出了一套实用的特性参数的计算公式.详细介绍了电力线阻波器、结合滤波器主要参数的测量原理.在硬件上,采用AD公司的AD8302为主测量芯片.由于利用了阻抗测量专用芯片,使得整个系统结构简单、抗干扰性能好、测量精度高、测量速度快.%Power wave trap coil and coupling filler is the important element in power line carrier systems.The accurate measurement for the characteristic parameter is security of the power line carrier communication and power system proper analyzed the characteristic of test equipment in this article,and brought up a series of formula for characteristic parameter introduced the key parameter measurement principle for the wave trap coil of power line and the combining wave filter in details.In aspect of hardware, it used AD8302 from AD company as main measurement chip.Thanks to the usage of impedance measurement chip.the whole system become simply structured, strongly anti-jamming,aecurale measurement and rapidly measurement.

  11. Analysis on Interior Ballistics of Multi-stage Inductive Coil Gun Based on Coupling of Field and Circuit%基于场路耦合的多级感应线圈炮内弹道分析

    向红军; 李治源; 雷彬


    To study the interior ballistic characteristics of multi-stage inductive coil gun such as the acceleration process,force and overload at the armature, the mathematical model was built based on the theory of electromagnetic field, and then the governing equations and calculation method of electromagnetic force on armature were given. The three-stage inductive coil gun was simulated based on the coupling model of field and circuit. The maximum overload obtained by the simulation model is 15 000g. The results show that the armature suffers great overload during launching process, and the direction of the electromagnetic force on armature reverses in motion. The reverse time of electromagnetic force will be brought forward with the increase of armature velocity, and the brake force will increase, and the acceleration force will decrease.%为研究多级感应线圈炮中电枢的受力、加速和过载等内弹道特性,基于电磁场理论,建立了同步感应线圈炮的数学模型,并给出了线圈炮的控制方程和电磁力计算方法.结合场路耦合模型,对3级感应线圈炮进行了有限元仿真.该仿真模型得到的最大过载可达15 000g.仿真分析表明:发射过程中,电枢不仅会受到很大的过载,而且其受到的电磁力在运动中会发生反向;随着电枢速度的提高,电磁力反向时刻不断提前,电磁制动力不断增大,加速力不断减小.

  12. Commercial applications for COIL

    Solomon, Wayne C.; Carroll, David L.; King, D. M.; Fockler, L. A.; Stromberg, D. S.; Sexauer, M.; Milmoe, A.; Sentman, Lee H.


    The chemical oxygen-iodine laser (COIL) is a high power, fiber deliverable tool, which can be used for a number of different industrial applications. COIL is of particular interest because of its short fiber deliverable wavelength, high scaleable continuous wave power, and excellent material interaction properties. In past research the University of Illinois at Urbana-Champaign identified and decommissioning and decontamination (DD) of nuclear facilities as a primary focus for COIL technology. DD will be a major challenge in the coming decades. The use of a robotically driven fiber delivered cutting/ablation tool in contaminated areas promises to lower risks to workers for the DD mission. Further, the high cutting speed of COIL will significantly reduce the time required to cut contaminated equipment, reducing costs. The high power of COIL will permit the dismantling of thick stacks of piping and equipment as well as reactor vessels. COIL is very promising for the removal of material from contaminated surfaces, perhaps to depths thicker than an inch. Laser cutting and ablation minimizes dust and fumes, which reduces the required number of high efficiency particulate accumulator filters, thus reducing costly waste disposal. Other potential industrial applications for COIL are shipbuilding, automotive manufacturing, heavy machinery manufacturing, tasks requiring underwater cutting or welding, and there appear to be very promising applications for high powers lasers in the oil industry.

  13. Effects of coil length on tube compression in electromagnetic forming


    The effects of the length of solenoid coil on tube compression in electromagnetic forming were investigated either by theory analysis or through sequential coupling numerical simulation. The details of the electromagnetic and the mechanical models in the simulation were described. The results show that the amplitude of coil current waveform and the current frequency decrease with the increase of the coil length. And the peak value of magnetic pressure is inversely proportional to the coil length. The distribution of the magnetic force acting on the tube is inhomogeneous while the tube is longer than the coil. The shortened coil length causes the increases of the maximum deformation and energy efficiency. The numerically calculated result and the experimental one of the final tube profile are in good agreement.

  14. A periodic table of coiled-coil protein structures.

    Moutevelis, Efrosini; Woolfson, Derek N


    Coiled coils are protein structure domains with two or more alpha-helices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a "periodic table of coiled coils," which we have made available at In this table, coiled-coil assemblies are arranged in columns with increasing numbers of alpha-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies.

  15. Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.

    Toth, Peter; Tarantini, Stefano; Tucsek, Zsuzsanna; Ashpole, Nicole M; Sosnowska, Danuta; Gautam, Tripti; Ballabh, Praveen; Koller, Akos; Sonntag, William E; Csiszar, Anna; Ungvari, Zoltan


    Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance of normal neuronal function. Increased oxidative stress that occurs with aging was shown to impair neurovascular coupling, which likely contributes to a significant age-related decline in higher cortical function, increasing the risk for vascular cognitive impairment. Resveratrol is a polyphenolic compound that exerts significant antiaging protective effects in large vessels, but its effects on the cerebromicrovasculature remain poorly defined. The present study was undertaken to investigate the capacity of resveratrol to improve neurovascular coupling in aging. In aged (24-mo-old) C57BL/6 mice N(ω)-nitro-l-arginine methyl ester-sensitive, nitric oxide-mediated CBF responses to whisker stimulation and to the endothelium-dependent dilator acethylcholine (ACh) were impaired compared with those in young (3-mo-old) mice. Treatment of aged mice with resveratrol rescued neurovascular coupling and ACh-induced responses, which was associated with downregulation of cortical expression of NADPH oxidase and decreased levels of biomarkers of oxidative/nitrative stress (3-nitrotyrosine, 8-isoprostanes). Resveratrol also attenuated age-related increases in reactive oxygen species (ROS) production in cultured cerebromicrovascular endothelial cells (DCF fluorescence, flow cytometry). In conclusion, treatment with resveratrol rescues cortical neurovascular coupling responses to increased neuronal activity in aged mice, likely by restoring cerebromicrovascular endothelial function via downregulation of NADPH oxidase-derived ROS production. Beneficial cerebromicrovascular effects of resveratrol may contribute to its protective effects on cognitive function in aging.

  16. LHCb magnet coils arrive

    Maximilien Brice


    Each of the two coils for the LHCb magnet comprises 15 individual monolayer 'pancakes' of identical trapezoidal racetrack shape, and is bent at 45 degrees on the two transverse sides. Each pancake consists of eight turns of conductor, wound from a single length (approx. 290 m) of extruded aluminium. The coils have arrived at CERN; one of them is seen here being unloaded above the LHCb experimental cavern.

  17. Coiling of yield stress fluids

    Y. Rahmani; M. Habibi; A. Javadi; D. Bonn


    We present an experimental investigation of the coiling of a filament of a yield stress fluid falling on a solid surface. We use two kinds of yield stress fluids, shaving foam and hair gel, and show that the coiling of the foam is similar to the coiling of an elastic rope. Two regimes of coiling (el

  18. Linear Rogowski coil

    Nassisi, V.; Delle Side, D.


    Nowadays, the employment and development of fast current pulses require sophisticated systems to perform measurements. Rogowski coils are used to diagnose cylindrical shaped beams; therefore, they are designed and built with a toroidal structure. Recently, to perform experiments of radiofrequency biophysical stresses, flat transmission lines have been developed. Therefore, in this work we developed a linear Rogowski coil to detect current pulses inside flat conductors. The system is first approached by means of transmission line theory. We found that, if the pulse width to be diagnosed is comparable with the propagation time of the signal in the detector, it is necessary to impose a uniform current as input pulse, or to use short coils. We further analysed the effect of the resistance of the coil and the influence of its magnetic properties. As a result, the device we developed is able to record pulses lasting for some hundreds of nanoseconds, depending on the inductance, load impedance, and resistance of the coil. Furthermore, its response is characterized by a sub-nanosecond rise time (˜100 ps). The attenuation coefficient depends mainly on the turn number of the coil, while the fidelity of the response depends both on the magnetic core characteristics and on the current distribution along the plane conductors.

  19. Electrical engineering. Coiling of rotating machines; Genie electrique. Bobinage des machines tournantes a courant alternatif

    Saint-Michel, J. [Moteurs Leroy Somer, 16 - Angouleme (France)


    This article treats of the poly-phase coiling of AC rotating machines. For simplification reasons, the study has been limited to tri-phase coils, but the theoretical calculations can be extended to any other number of phases. The coils described are those encountered in the stators of synchronous and asynchronous machines and in the rotors of asynchronous machines with rings. The qualitative, quantitative and practical aspects are presented successively: 1 - magnetic field produced by a coil (single turn, distributed coil, coil schemes, multi-polarity coils); 2 - field generated by a tri-phase coil (rotating field theorem, qualitative influence of space harmonics); 3 - quantitative analysis of coil properties (magneto-motive force generated by coils, harmonic decomposition of the magneto-motive force wave, global coiling coefficients); 4 - comparative study of different regular coils (diametrical step, shortened step, distributed); 5 - irregular coils; 6 - other double polarity coils (Dahlander coupling, other multiple polarity possibilities); 7 - reduction of teething harmonics (determination of optimal twisting, influence of inclination on the dimensioning of machines); 8 - practical realization of coils (insulation, insertion inside the machine). (J.S.)

  20. Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.

    Vitzthum, Helga; Seniuk, Anika; Schulte, Laura Helene; Müller, Maxie Luise; Hetz, Hannah; Ehmke, Heimo


    A network of kinases, including WNKs, SPAK and Sgk1, is critical for the independent regulation of K+ and Na+ transport in the distal nephron. Angiotensin II is thought to act as a key hormone in orchestrating these kinases to switch from K+ secretion during hyperkalaemia to Na+ reabsorption during intravascular volume depletion, thus keeping disturbances in electrolyte and blood pressure homeostasis at a minimum. It remains unclear, however, how K+ and Na+ transport are regulated during a high Na+ intake, which is associated with suppressed angiotensin II levels and a high distal tubular Na+ load. We therefore investigated the integrated blood pressure, renal, hormonal and gene and protein expression responses to large changes of K+ intake in Na+ replete mice. Both low and high K+ intake increased blood pressure and caused Na+ retention. Low K+ intake was accompanied by an upregulation of the sodium-chloride cotransporter (NCC) and its activating kinase SPAK, and inhibition of NCC normalized blood pressure. Renal responses were unaffected by angiotensin AT1 receptor antagonism, indicating that low K+ intake activates the distal nephron by an angiotensin-independent mode of action. High K+ intake was associated with elevated plasma aldosterone concentrations and an upregulation of the epithelial sodium channel (ENaC) and its activating kinase Sgk1. Surprisingly, high K+ intake increased blood pressure even during ENaC or mineralocorticoid receptor antagonism, suggesting the contribution of aldosterone-independent mechanisms. These findings show that in a Na+ replete state, changes in K+ intake induce specific molecular and functional adaptations in the distal nephron that cause a functional coupling of renal K+ and Na+ handling, resulting in Na+ retention and high blood pressure when K+ intake is either restricted or excessively increased.

  1. Coiled coils and SAH domains in cytoskeletal molecular motors.

    Peckham, Michelle


    Cytoskeletal motors include myosins, kinesins and dyneins. Myosins move along tracks of actin filaments, whereas kinesins and dyneins move along microtubules. Many of these motors are involved in trafficking cargo in cells. However, myosins are mostly monomeric, whereas kinesins are mostly dimeric, owing to the presence of a coiled coil. Some myosins (myosins 6, 7 and 10) contain an SAH (single α-helical) domain, which was originally thought to be a coiled coil. These myosins are now known to be monomers, not dimers. The differences between SAH domains and coiled coils are described and the potential roles of SAH domains in molecular motors are discussed.

  2. Phase transitions within the isolated polymer molecule: Coupling of the polymer threading a membrane transition to the helix-random coil, the collapse, the adsorption, and the equilibrium polymerization transitions

    Di Marzio, Edmund A.; Kasianowicz, John J.


    The polymer threading a membrane transition (PTM), which is a first-order thermodynamic phase transition for an isolated linear polymer in the limit of infinite molecular weight, is coupled to the other four phase transitions of the isolated polymer molecule. They are (1) the helix-random coil (HR) phase transition which can be diffuse (polypeptides), second-order (DNA) or first-order (collagen) depending on the number of strands, (2) the collapse (C) transition which is usually second-order but can be first-order for polymeric solvents, (3) adsorption onto a surface (SA) which is second-order, (4) a model of equilibrium polymerization (P) which is first-order. In each case an exact expression for the partition function of the coupled pair is given as a one-dimensional summation over products of the individual partition functions corresponding to sides 1 and 2. Using a procedure analogous to evaluation of the grand canonical ensemble the summation can be performed and the character of the transition elucidated in the limit of infinite molecular weight. Given that the solutions on either side are sufficiently diverse there are 15 possible translocation pair couplings. They are PTM-PTM, HR-HR, C-C, SA-SA, P-P, PTM-HR, PTM-C, PTM-SA, PTM-P, HR-C, HR-SA, HR-P, C-SA, C-P, SA-P. The PTM-P coupling is most interesting because one can create polymer in the PTM side even though the P side is in the depolymerization regime. For HR-HR there are eight possible translocation modes. For example, as we raise the temperature we can have H1→H2→R1→R2 in obvious notation. These exact model solutions provide a thermodynamic base for the study of the kinetics of significant technological problems such as the translocation of DNA through pores imbedded in membranes. They also throw light on the nature of polymer-membrane-pore interactions in living cells and viruses.

  3. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1.

    Fujiwara, Yuichiro; Kurokawa, Tatsuki; Takeshita, Kohei; Kobayashi, Megumi; Okochi, Yoshifumi; Nakagawa, Atsushi; Okamura, Yasushi


    Hv1/VSOP is a dimeric voltage-gated H(+) channel in which the gating of one subunit is reportedly coupled to that of the other subunit within the dimer. The molecular basis for dimer formation and intersubunit coupling, however, remains unknown. Here we show that the carboxy terminus ends downstream of the S4 voltage-sensor helix twist in a dimer coiled-coil architecture, which mediates cooperative gating. We also show that the temperature-dependent activation of H(+) current through Hv1/VSOP is regulated by thermostability of the coiled-coil domain, and that this regulation is altered by mutation of the linker between S4 and the coiled-coil. Cooperative gating within the dimer is also dependent on the linker structure, which circular dichroism spectrum analysis suggests is α-helical. Our results indicate that the cytoplasmic coiled-coil strands form continuous α-helices with S4 and mediate cooperative gating to adjust the range of temperatures over which Hv1/VSOP operates.

  4. TESLA Coil Research


    Sloan’s work was actually predated by the earlier work of Nikola Tesla . Sloan mistakenly identified " Tesla Coils" as lumped tuned resonators. The...Lefvw WsnJ L REPORT o]i 3. REPRT TYPE AND OATES COVEIRD May 1992 Special/Aug 1992 - May 1992 Z TITLE AND 5U§nUT S. FUNDING NUMIHRS Tesla Coil Research...STATEMENT 1211. ’ISTRIUUTION COOD Approved for public release; dis~ribution is unlimited 13. ABSTRACT (Masrmum 200 worw) High repetition rate Tesla

  5. Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe

    Okuzaki Daisuke


    Full Text Available Abstract Many meiosis-specific proteins in Schizosaccharomyces pombe contain coiled-coil motifs which play essential roles for meiotic progression. For example, the coiled-coil motifs present in Meu13 and Mcp7 are required for their function as a putative recombinase cofactor complex during meiotic recombination. Mcp6/Hrs1 and Mcp5/Num1 control horsetail chromosome movement by astral microtubule organization and anchoring dynein respectively. Dhc1 and Ssm4 are also required for horsetail chromosome movement. It is clear from these examples that the coiled-coil motif in these proteins plays an important role during the progression of cells through meiosis. However, there are still many unanswered questions on how these proteins operate. In this paper, we briefly review recent studies on the meiotic coiled-coil proteins in Sz. pombe.

  6. Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.

    Flagg, Thomas P; Charpentier, Flavien; Manning-Fox, Jocelyn; Remedi, Maria Sara; Enkvetchakul, Decha; Lopatin, Anatoli; Koster, Joseph; Nichols, Colin


    Reducing the ATP sensitivity of the sarcolemmal ATP-sensitive K(+) (K(ATP)) channel is predicted to lead to active channels in normal metabolic conditions and hence cause shortened ventricular action potentials and reduced myocardial inotropy. We generated transgenic (TG) mice that express an ATP-insensitive K(ATP) channel mutant [Kir6.2(deltaN2-30,K185Q)] under transcriptional control of the alpha-myosin heavy chain promoter. Strikingly, myocyte contraction amplitude was increased in TG myocytes (15.68 +/- 1.15% vs. 10.96 +/- 1.49%), even though K(ATP) channels in TG myocytes are very insensitive to inhibitory ATP. Under normal metabolic conditions, steady-state outward K(+) currents measured under whole cell voltage clamp were elevated in TG myocytes, consistent with threshold K(ATP) activation, but neither the monophasic action potential measured in isolated hearts nor transmembrane action potential measured in right ventricular muscle preparations were shortened at physiological pacing cycles. Taken together, these results suggest that there is a compensatory remodeling of excitation-contraction coupling in TG myocytes. Whereas there were no obvious differences in other K(+) conductances, peak L-type Ca(2+) current (I(Ca)) density (-16.42 +/- 2.37 pA/pF) in the TG was increased compared with the wild type (-8.43 +/- 1.01 pA/pF). Isoproterenol approximately doubled both I(Ca) and contraction amplitude in wild-type myocytes but failed to induce a significant increase in TG myocytes. Baseline and isoproterenol-stimulated cAMP concentrations were not different in wild-type and TG hearts, suggesting that the enhancement of I(Ca) in the latter does not result from elevated cAMP. Collectively, the data demonstrate that a compensatory increase in I(Ca) counteracts a mild activation of ATP-insensitive K(ATP) channels to maintain the action potential duration and elevate the inotropic state of TG hearts.

  7. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.

    Hui Li

    Full Text Available Ovarian cancer G protein-coupled receptor 1 (OGR1 has been shown to be a proton sensing receptor in vitro. We have shown that OGR1 functions as a tumor metastasis suppressor gene when it is over-expressed in human prostate cancer cells in vivo. To examine the physiological functions of OGR1, we generated conditional OGR1 deficient mice by homologous recombination. OGR1 deficient mice were viable and upon gross-inspection appeared normal. Consistent with in vitro studies showing that OGR1 is involved in osteoclastogenesis, reduced osteoclasts were detected in OGR1 deficient mice. A pH-dependent osteoclasts survival effect was also observed. However, overall abnormality in the bones of these animals was not observed. In addition, melanoma cell tumorigenesis was significantly inhibited in OGR1 deficient mice. OGR1 deficient mice in the mixed background produced significantly less peritoneal macrophages when stimulated with thioglycolate. These macrophages also showed altered extracellular signal-regulated kinases (ERK activation and nitric oxide (NO production in response to lipopolysaccharide. OGR1-dependent pH responses assessed by cAMP production and cell survival in macrophages or brown fat cells were not observed, presumably due to the presence of other proton sensing receptors in these cells. Our results indicate that OGR1's role in osteoclastogenesis is not strong enough to affect overall bone development and its role in tumorigenesis warrants further investigation. The mice generated can be potentially used for several disease models, including cancers or osteoclast-related diseases.

  8. Planar, monolithically integrated coil

    Roozeboom, F.; Reefman, D.; Klootwijk, J.H.; Tiemeijer, L.F.; Ruigrok, J.


    The present invention provides a means to integrate planar coils on silicon, while providing a high inductance. This high inductance is achieved through a special back- and front sided shielding of a material. In many applications, high-value inductors are a necessity. In particular, this holds for

  9. An orientable search coil

    Holt, P. J.; Poblocki, M.


    We provide a design for a low cost orientable search coil that can be used to investigate the variation of magnetic flux with angle. This experiment is one of the required practical activities in the current A level physics specification for the AQA examination board in the UK. We demonstrate its performance and suggest other suitable investigations that can be undertaken.

  10. Misalignment tolerable coil structure for biomedical applications with wireless power transfer.

    Chow, Jeff P W; Chen, Nan; Chung, Henry S H; Chan, Leanne L H


    Coil-misalignment is one of the major hurdles for inductively coupled wireless power transfer in applications like retinal prosthesis. Weak magnetic flux linkage due to coil misalignments would significantly impair the power efficiency. A novel receiver configuration with high misalignment tolerance is presented in this paper. The proposed receiver is composed of two receiver coils placed orthogonally, so as to reduce the variation of mutual inductance between transmitting and receiving coils under misalignment conditions. Three different receiver coil structures are analyzed and compared using the same length of wire. Theoretical predictions have been confirmed with measurement results.

  11. Na+ Dysregulation Coupled with Ca2+ Entry through NCX1 Promotes Muscular Dystrophy in Mice

    Burr, Adam R.; Millay, Douglas P.; Goonasekera, Sanjeewa A.; Park, Ki Ho; Sargent, Michelle A.; Collins, James; Altamirano, Francisco; Philipson, Kenneth D.; Allen, Paul D.; Ma, Jianjie; López, José Rafael


    Unregulated Ca2+ entry is thought to underlie muscular dystrophy. Here, we generated skeletal-muscle-specific transgenic (TG) mice expressing the Na+-Ca2+ exchanger 1 (NCX1) to model its identified augmentation during muscular dystrophy. The NCX1 transgene induced dystrophy-like disease in all hind-limb musculature, as well as exacerbated the muscle disease phenotypes in δ-sarcoglycan (Sgcd−/−), Dysf−/−, and mdx mouse models of muscular dystrophy. Antithetically, muscle-specific deletion of the Slc8a1 (NCX1) gene diminished hind-limb pathology in Sgcd−/− mice. Measured increases in baseline Na+ and Ca2+ in dystrophic muscle fibers of the hind-limb musculature predicts a net Ca2+ influx state due to reverse-mode operation of NCX1, which mediates disease. However, the opposite effect is observed in the diaphragm, where NCX1 overexpression mildly protects from dystrophic disease through a predicted enhancement in forward-mode NCX1 operation that reduces Ca2+ levels. Indeed, Atp1a2+/− (encoding Na+-K+ ATPase α2) mice, which have reduced Na+ clearance rates that would favor NCX1 reverse-mode operation, showed exacerbated disease in the hind limbs of NCX1 TG mice, similar to treatment with the Na+-K+ ATPase inhibitor digoxin. Treatment of Sgcd−/− mice with ranolazine, a broadly acting Na+ channel inhibitor that should increase NCX1 forward-mode operation, reduced muscular pathology. PMID:24662047

  12. Analysis and experimental study of wireless power transfer with HTS coil and copper coil as the intermediate resonators system

    Wang, Xiufang; Nie, Xinyi; Liang, Yilang; Lu, Falong; Yan, Zhongming; Wang, Yu


    Intermediate resonator (repeater) between transmitter and receiver can significantly increase the distance of wireless power transfer (WPT) and the efficiency of wireless power transfer. The wireless power transfer via strongly coupled magnetic resonances with an high temperature superconducting (HTS) coil and copper coil as intermediate resonators was presented in this paper. The electromagnetic experiment system under different conditions with different repeating coils were simulated by finite element software. The spatial distribution patterns of magnetic induction intensity at different distances were plotted. In this paper, we examined transfer characteristics with HTS repeating coil and copper repeating coil at 77 K and 300 K, respectively. Simulation and experimental results show that HTS and copper repeating coil can effectively enhance the space magnetic induction intensity, which has significant effect on improving the transmission efficiency and lengthening transmission distance. We found that the efficiency and the distance of wireless power transfer system with an HTS coil as repeater is much higher by using of copper coil as repeater.

  13. Minimax Current Density Coil Design

    Poole, Michael; Lopez, Hector Sanchez; Ng, Michael; Crozier, Stuart; 10.1088/0022-3727/43/9/095001


    'Coil design' is an inverse problem in which arrangements of wire are designed to generate a prescribed magnetic field when energized with electric current. The design of gradient and shim coils for magnetic resonance imaging (MRI) are important examples of coil design. The magnetic fields that these coils generate are usually required to be both strong and accurate. Other electromagnetic properties of the coils, such as inductance, may be considered in the design process, which becomes an optimization problem. The maximum current density is additionally optimized in this work and the resultant coils are investigated for performance and practicality. Coils with minimax current density were found to exhibit maximally spread wires and may help disperse localized regions of Joule heating. They also produce the highest possible magnetic field strength per unit current for any given surface and wire size. Three different flavours of boundary element method that employ different basis functions (triangular elements...

  14. Thermophoresis of polymers: nondraining vs draining coil.

    Morozov, Konstantin I; Köhler, Werner


    Present theories for the thermophoretic mobility of polymers in dilute solution without long-ranged electrostatic interaction are based on a draining coil model with short-ranged segment-solvent interaction. We show that the characteristic thermophoretic interaction decays as r(-2) with the distance from the chain segment, which is of much longer range than the underlying rapidly decaying binary van der Waals interaction (∝ r(-6)). As a consequence, thermophoresis on the monomer level is governed by volume forces, resulting in hydrodynamic coupling between the chain segments. The inner parts of the nondraining coil do not actively participate in thermophoresis. The flow lines penetrate only into a thin surface layer of the coil and cause tangential stresses along the surface of the entire coil, not the individual segments. This model is motivated by recent experimental findings for thermoresponsive polymers and core-shell particles, and it explains the well-known molar mass independent thermophoretic mobility of polymers in dilute solution.

  15. Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.

    G.T.J. van der Horst (Gijsbertus); H. van Steeg (Harry); R.J.W. Berg (Rob); A.J. van Gool (Alain); J. de Wit (Jan); G. Weeda (Geert); H. Morreau (Hans); R.B. Beems (Rudolf); C.F. van Kreijl (Coen); F.R. de Gruijl (Frank); D. Bootsma (Dirk); J.H.J. Hoeijmakers (Jan)


    textabstractA mouse model for the nucleotide excision repair disorder Cockayne syndrome (CS) was generated by mimicking a truncation in the CSB(ERCC6) gene of a CS-B patient. CSB-deficient mice exhibit all of the CS repair characteristics: ultraviolet (UV) sensitivity, inactivation of transcription-

  16. DC SQUIDS with planar input coils

    Pegrum, C.M.; Donaldson, G.B.; Hutson, D.; Tugwell, A.


    We describe the key parts of our recent work to develop a planar thin-film DC SQUID with a closely-coupled spiral input coil. Our aim has been to make a device that is superior to present RF SQUID sensors in terms of sensitivity and long-term reliability. To be compatible with an RF SQUID the inductance of the input coils must be relatively large, typically, and the input noise current in the white noise region should be below 10pA Hz /SUP -1/2/ . A low level of 1/f noise is also necessary for many applications and should be achieved without the use of complex noisecancelling circuitry. Our devices meet these criteria. We include a description of work on window and edge junction fabrication using ion beam cleaning, thermal oxidation and RF plasma processing.

  17. Introduction to COIL

    Kane, David


    By reciprocal arrangement between WIT and the National College of Ireland, you are now able to access their collection directly - more than 100,000 items. This form of direct consortial borrowing has never been tried before in Ireland. Before you borrow your first book, you will have to set up a COIL account, which is straightforward. The items which you reserve online will be posted to us, for you to collect, at the front desk in the Luke Wadding library, afterwards. The Initiat...

  18. Inductively-overcoupled coil design for high resolution magnetic resonance imaging

    Bilgen Mehmet


    Full Text Available Abstract Background Maintaining the quality of magnetic resonance images acquired with the current implantable coil technology is challenging in longitudinal studies. To overcome this challenge, the principle of 'inductive overcoupling' is introduced as a method to tune and match a dual coil system. This system consists of an imaging coil built with fixed electrical elements and a matching coil equipped with tuning and matching capabilities. Overcoupling here refers to the condition beyond which the peak of the current in the imaging coil splits. Methods The combined coils are coupled inductively to operate like a transformer. Each coil circuit is electrically represented by equivalent lumped-elements. A theoretical analysis is given to identify the frequency response characteristics of the currents in each coil. The predictions from this analysis are translated into experiments and applied to locally image rat spinal cord at 9.4 T using an implantable coil as the imaging coil and an external volume coil as the matching coil. Results The theoretical analysis indicated that strong coupling between the coils divides the resonance peaks on the response curves of the currents. Once these newly generated peaks were tuned and matched to the desired frequency and impedance of operation, in vivo images were acquired from the rat spinal cord at high quality and high resolution. Conclusion After proper implementation, inductive overcoupling provides a unique opportunity for tuning and matching the coil system, and allows reliable and repeatable acquisitions of magnetic resonance data. This feature is likely to be useful in experimental studies, such as those aimed at longitudinally imaging the rat following spinal cord injury.

  19. Triple Halo Coil: Development and Comparison with Other TMS Coils

    Rastogi, Priyam; Hadimani, Ravi; Jiles, David

    Transcranial Magnetic Stimulation (TMS) is a non-invasive stimulation technique that can be used for the treatment of various neurological disorders such as Parkinson's Disease, PTSD, TBI and anxiety by regulating synaptic activity. TMS is FDA approved for the treatment of major depressive disorder. There is a critical need to develop deep TMS coils that can stimulate deeper regions of the brain without excessively stimulating the cortex in order to provide an alternative to surgical methods. We have developed a novel multi-coil configuration called ``Triple Halo Coil'' (THC) that can stimulate deep brain regions. Investigation of induced electric and magnetic field in these regions have been achieved by computer modelling. Comparison of the results due to THC configuration have been conducted with other TMS coils such as ``Halo Coil'', circular coil and ``Figure of Eight'' coil. There was an improvement of more than 15 times in the strength of magnetic field, induced by THC configuration at 10 cm below the vertex of the head when compared with the ``Figure of Eight'' coil alone. Carver Charitable Trust.

  20. In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy.

    Ando, Yoriko; Sakurai, Takashi; Koida, Kowa; Tei, Hajime; Hida, Akiko; Nakao, Kazuki; Natsume, Mistuo; Numano, Rika


    Bioluminescence imaging (BLI) is used in biomedical research to monitor biological processes within living organisms. Recently, fiber bundles with high transmittance and density have been developed to detect low light with high resolution. Therefore, we have developed a bundled-fiber-coupled microscope with a highly sensitive cooled-CCD camera that enables the BLI of organs within the mouse body. This is the first report of in vivo BLI of the brain and multiple organs in luciferase-reporter mice using bundled-fiber optics. With reflectance imaging, the structures of blood vessels and organs can be seen clearly with light illumination, and it allowed identification of the structural details of bioluminescence images. This technique can also be applied to clinical diagnostics in a low invasive manner.

  1. In vivo bioluminescence and reflectance imaging of multiple organs in bioluminescence reporter mice by bundled-fiber-coupled microscopy

    Ando, Yoriko; Sakurai, Takashi; Koida, Kowa; Tei, Hajime; Hida, Akiko; Nakao, Kazuki; Natsume, Mistuo; Numano, Rika


    Bioluminescence imaging (BLI) is used in biomedical research to monitor biological processes within living organisms. Recently, fiber bundles with high transmittance and density have been developed to detect low light with high resolution. Therefore, we have developed a bundled-fiber-coupled microscope with a highly sensitive cooled-CCD camera that enables the BLI of organs within the mouse body. This is the first report of in vivo BLI of the brain and multiple organs in luciferase-reporter mice using bundled-fiber optics. With reflectance imaging, the structures of blood vessels and organs can be seen clearly with light illumination, and it allowed identification of the structural details of bioluminescence images. This technique can also be applied to clinical diagnostics in a low invasive manner. PMID:27231601

  2. Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.

    Michael P Siegel

    Full Text Available Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear. We used both pharmacological (2 week paraquat (PQ treatment of wild type mice and transgenic (mice lacking Cu, Zn-superoxide dismutase (SOD1(-/- models to test the effect of oxidative stress on in vivo mitochondrial function in skeletal muscle. Magnetic resonance and optical spectroscopy were used to measure mitochondrial ATP and oxygen fluxes and cell energetic state. In both models of oxidative stress, coupling of oxidative phosphorylation was significantly lower (lower P/O at rest in vivo in skeletal muscle and was dose-dependent in the PQ model. Despite this reduction in efficiency, in vivo mitochondrial phosphorylation capacity (ATPmax was maintained in both models, and ex vivo mitochondrial respiration in permeabilized muscle fibers was unchanged following PQ treatment. In association with the reduced P/O, PQ treatment led to a dose-dependent reduction in PCr/ATP ratio and increased phosphorylation of AMPK. These results indicate that oxidative stress uncouples oxidative phosphorylation in vivo and results in energetic stress in the absence of defects in the mitochondrial electron transport chain.

  3. Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice

    Cong, Xiaofei; Doering, Jonathan; Grange, Robert W.; Jiang, Honglin


    The Stac3 gene is exclusively expressed in skeletal muscle, and Stac3 knockout is perinatal lethal in mice. Previous data from Stac3-deleted diaphragms indicated that Stac3-deleted skeletal muscle could not contract because of defective excitation-contraction (EC) coupling. In this study, we determined the contractility of Stac3-deleted hindlimb muscle. In response to frequent electrostimulation, Stac3-deleted hindlimb muscle contracted but the maximal tension generated was only 20% of that in control (wild type or heterozygous) muscle (P < 0.05). In response to high [K+], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated in Stac3-deleted muscle were 29% (P < 0.05), 58% (P = 0.08), and 55% (P < 0.05) of those in control muscle, respectively. In response to 4-CMC or caffeine, over 90% of myotubes formed from control myoblasts contracted, but only 60% of myotubes formed from Stac3-deleted myoblasts contracted (P = 0.05). However, in response to 4-CMC or caffeine, similar increases in intracellular calcium concentration were observed in Stac3-deleted and control myotubes. Gene expression and histological analyses revealed that Stac3-deleted hindlimb muscle contained more slow type-like fibers than control muscle. These data together confirm a critical role of STAC3 in EC coupling but also suggest that STAC3 may have additional functions in skeletal muscle, at least in the hindlimb muscle. PMID:27184118

  4. Multi-port-driven birdcage coil for multiple-mouse MR imaging at 7 T.

    Heo, Phil; Seo, Jeung-Hoon; Han, Sang-Doc; Ryu, Yeunchul; Byun, Jong-Deok; Kim, Kyoung-Nam; Lee, Jung Hee


    In ultra-high field (UHF) imaging environments, it has been demonstrated that multiple-mouse magnetic resonance imaging (MM-MRI) is dependent on key factors such as the radiofrequency (RF) coil hardware, imaging protocol, and experimental setup for obtaining high-resolution MR images. A key aspect is the RF coil, and a number of MM-MRI studies have investigated the application of single-channel RF transmit (Tx)/receive (Rx) coils or multi-channel phased array (PA) coil configurations under a single gradient coil set. However, despite applying a variety of RF coils, Tx (|B1(+) |)-field inhomogeneity still remains a major problem due to the relative shortening of the effective RF wavelength in the UHF environment. To address this issue, we propose a relatively smaller size of individual Tx-only coils in a multiple birdcage (MBC) coil for MM-MRI to image up to three mice. We use electromagnetic (EM) simulations in the finite-difference time-domain (FDTD) environment to obtain the |B1 |-field distribution. Our results clearly show that the single birdcage (SBC) high-pass filter (HPF) configuration, which is referred to as the SBCHPF , under the absence of an RF shield exhibits a high |B1 |-field intensity in comparison with other coil configurations such as the low-pass filter (LPF) and band-pass filter (BPF) configurations. In a 7-T MRI experiment, the signal-to-noise ratio (SNR) map of the SBCHPF configuration shows the highest coil performance compared to other coil configurations. The MBCHPF coil, which is comprised of a triple-SBCHPF configuration combined with additional decoupling techniques, is developed for simultaneous image acquisition of three mice. SCANNING 38:747-756, 2016. © 2016 Wiley Periodicals, Inc.

  5. Structural and biochemical characterizations of an intramolecular tandem coiled coil protein.

    Shin, Donghyuk; Kim, Gwanho; Kim, Gyuhee; Zheng, Xu; Kim, Yang-Gyun; Lee, Sangho


    Coiled coil has served as an excellent model system for studying protein folding and developing protein-based biomaterials. Most designed coiled coils function as oligomers, namely intermolecular coiled coils. However, less is known about structural and biochemical behavior of intramolecular coiled coils where coiled coil domains are covalently linked in one polypeptide. Here we prepare a protein which harbors three coiled coil domains with two short linkers, termed intramolecular tandem coiled coil (ITCC) and characterize its structural and biochemical behavior in solution. ITCC consists of three coiled coil domains whose sequences are derived from Coil-Ser and its domain swapped dimer. Modifications include positioning E (Glu) residue at "e" and K (Lys) at "g" positions throughout heptad repeats to enhance ionic interaction among its constituent coiled coil domains. Molecular modeling of ITCC suggests a compact triple helical bundle structure with the second and the third coiled coil domains forming a canonical coiled coil. ITCC exists as a mixture of monomeric and dimeric species in solution. Small-angle X-ray scattering reveals ellipsoidal molecular envelopes for both dimeric and monomeric ITCC in solution. The theoretically modeled structures of ITCC dock well into the envelopes of both species. Higher ionic strength shifts the equilibrium into monomer with apparently more compact structure while secondary structure remains unchanged. Taken together, our results suggest that our designed ITCC is predominantly monomeric structure through the enhanced ionic interactions, and its conformation is affected by the concentration of ionic species in the buffer.

  6. Manufacturing of REBCO coils strongly bonded to cooling members with epoxy resin aimed at its application to Maglev

    Mizuno, Katsutoshi; Ogata, Masafumi; Hasegawa, Hitoshi


    The REBCO coated conductor has been attracted attention because of its high current density in the presence of high magnetic field. If the coated conductor is applied to Maglev, the operational temperature of the on-board magnets will be over 40 K and energy consumption of cryocoolers will be reduced. That high operational temperature also means the absence of liquid helium. Therefore, reliable thermal coupling is desirable for cooling the coils. We propose an epoxy impregnated REBCO coil co-wound with PTFE tape. While the PTFE tape prevents the performance degradation of the coil, the epoxy resin bonds the coil to cooling members. We carried out three experiments to confirm that the coil structure which we propose has robust thermal coupling without the degradation. First, thermal resistances of paraffin and epoxy were measured varying the temperature from room temperature to 10 K. The measurement result indicates that paraffin has a risk of losing thermal coupling during cooling down. In another experiment, PTFE (polytetrafluoroethylene) tape insulator prevented performance degradation of a small epoxy impregnated REBCO coil, while another REBCO coil with polyimide tape showed clear performance degradation. Finally, we produced a racetrack REBCO coil with the same outer dimension as a Maglev on-board magnet coil. Although the racetrack coil was installed in a GFRP coil case and tightly bonded to the case by epoxy impregnation, any performance degradation was not observed.

  7. NMR of thin layers using a meanderline surface coil

    Cowgill, Donald F.


    A miniature meanderline sensor coil which extends the capabilities of nuclear magnetic resonance (NMR) to provide analysis of thin planar samples and surface layer geometries. The sensor coil allows standard NMR techniques to be used to examine thin planar (or curved) layers, extending NMRs utility to many problems of modern interest. This technique can be used to examine contact layers, non-destructively depth profile into films, or image multiple layers in a 3-dimensional sense. It lends itself to high resolution NMR techniques of magic angle spinning and thus can be used to examine the bonding and electronic structure in layered materials or to observe the chemistry associated with aging coatings. Coupling this sensor coil technology with an arrangement of small magnets will produce a penetrator probe for remote in-situ chemical analysis of groundwater or contaminant sediments. Alternatively, the sensor coil can be further miniaturized to provide sub-micron depth resolution within thin films or to orthoscopically examine living tissue. This thin-layer NMR technique using a stationary meanderline coil in a series-resonant circuit has been demonstrated and it has been determined that the flat meanderline geometry has about he same detection sensitivity as a solenoidal coil, but is specifically tailored to examine planar material layers, while avoiding signals from the bulk.

  8. Near-field wireless sensing of single and multiple open-ended micro coils

    A. Yousaf


    Full Text Available In this work we present near-field wireless sensing of single and multiple open-ended micro coils using an electrically small loop antenna. Wirelessly characterized parameters of open-ended micro coils include its resonance frequency, quality factor and inductance. Moreover a wireless frequency-dependent analytical model was developed. Micro coil inductance was extracted from the wirelessly measured signal using a constraint-based least-squares approach. Wireless measurements and analytical fit of micro coils are in strong agreement which validates the analytical model. Finite element method (FEM simulations of the coupled system were done in COMSOL Multiphysics.

  9. Investigation on an RFID planar coil for a wireless communicative aortic stent

    Talleb, Hakeim; Faci, Salim; Lautru, David; Hanna, Victor Fouad; Wiart, Joe


    This paper presents an investigation on a potential biomedical RFID planar coil operating at 13.56 MHz for measuring the blood pressure level, mounted inside an abdominal aortic aneurysm. The results show that a wireless communication is achieved in a perimeter of 60 cm, while respecting the ISO 15693 standard for vicinity contactless cards. Measurement and electromagnetic simulation results show that the inductive coupling is deteriorating if the planar coil is in direct contact with water without correctly encapsulating this coil. An electric model is given for our proposed RFID planar coil immersed in water.

  10. Manufacturing of REBCO coils strongly bonded to cooling members with epoxy resin aimed at its application to Maglev

    Mizuno, Katsutoshi, E-mail:; Ogata, Masafumi; Hasegawa, Hitoshi


    Highlights: • Paraffin has a risk of losing thermal coupling during cooling down. • We propose an epoxy impregnated REBCO coil co-wound with PTFE tape. • The coil is tightly bonded to cooling members by epoxy resin without the degradation. • We made a REBCO racetrack coil with the same outer dimension as the Maglev magnet. - Abstract: The REBCO coated conductor has been attracted attention because of its high current density in the presence of high magnetic field. If the coated conductor is applied to Maglev, the operational temperature of the on-board magnets will be over 40 K and energy consumption of cryocoolers will be reduced. That high operational temperature also means the absence of liquid helium. Therefore, reliable thermal coupling is desirable for cooling the coils. We propose an epoxy impregnated REBCO coil co-wound with PTFE tape. While the PTFE tape prevents the performance degradation of the coil, the epoxy resin bonds the coil to cooling members. We carried out three experiments to confirm that the coil structure which we propose has robust thermal coupling without the degradation. First, thermal resistances of paraffin and epoxy were measured varying the temperature from room temperature to 10 K. The measurement result indicates that paraffin has a risk of losing thermal coupling during cooling down. In another experiment, PTFE (polytetrafluoroethylene) tape insulator prevented performance degradation of a small epoxy impregnated REBCO coil, while another REBCO coil with polyimide tape showed clear performance degradation. Finally, we produced a racetrack REBCO coil with the same outer dimension as a Maglev on-board magnet coil. Although the racetrack coil was installed in a GFRP coil case and tightly bonded to the case by epoxy impregnation, any performance degradation was not observed.

  11. CCHMM_PROF: a HMM-based coiled-coil predictor with evolutionary information

    Bartoli, Lisa; Fariselli, Piero; Krogh, Anders;


    MOTIVATION: The widespread coiled-coil structural motif in proteins is known to mediate a variety of biological interactions. Recognizing a coiled-coil containing sequence and locating its coiled-coil domains are key steps towards the determination of the protein structure and function. Different...... tools are available for predicting coiled-coil domains in protein sequences, including those based on position-specific score matrices and machine learning methods. RESULTS: In this article, we introduce a hidden Markov model (CCHMM_PROF) that exploits the information contained in multiple sequence...... alignments (profiles) to predict coiled-coil regions. The new method discriminates coiled-coil sequences with an accuracy of 97% and achieves a true positive rate of 79% with only 1% of false positives. Furthermore, when predicting the location of coiled-coil segments in protein sequences, the method reaches...

  12. Coiled-coil conformation of a pentamidine-DNA complex.

    Moreno, Tadeo; Pous, Joan; Subirana, Juan A; Campos, J Lourdes


    The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)(2) with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A.T base pairs.

  13. Can Magnetic Coil Ease Tinnitus?

    ... Research Updates Technology Horizons Can magnetic coil ease tinnitus? VA trial aims to find out February 3, ... pain. See, for example, this 2009 review study . Tinnitus and Veterans Tinnitus has been one of the ...

  14. First coil for the SC

    CERN PhotoLab


    The coils for the SC magnet were stored in the large hangar of the Cointrin Airport (to make sure that they would be available before snow and ice would block the roads and canals from Belgium, where they were built).

  15. Adjustable Induction-Heating Coil

    Ellis, Rod; Bartolotta, Paul


    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  16. Nylon screws make inexpensive coil forms

    Aucoin, G.; Rosenthal, C.


    Standard nylon screws act as coil form copper wire laid down in spiral thread. Completed coil may be bonded to printed-circuit board. However, it is impossible to tune coil by adjusting spacing between windings, technique sometimes used with air-core coils.

  17. Nylon screws make inexpensive coil forms

    Aucoin, G.; Rosenthal, C.


    Standard nylon screws act as coil form copper wire laid down in spiral thread. Completed coil may be bonded to printed-circuit board. However, it is impossible to tune coil by adjusting spacing between windings, technique sometimes used with air-core coils.


    P. N. Dobrodeyev


    Full Text Available The optimal configuration of the double Helmholtz coils for measuring of the magnetic dipole moments was defined. It was determined that measuring coils should have round shape and compensative coils – the square one. Analytically confirmed the feasibility of the proposed configuration of these coils as primary transmitters of magnetic dipole moments.

  19. A 2-in-1 single-element coil design for transcranial magnetic stimulation and magnetic resonance imaging.

    Lu, Hai; Wang, Shumin


    To demonstrate the feasibility of turning transcranial magnetic stimulation (TMS) coil for MRI signal reception. A critically coupled network was formed by using a resonated turn of TMS coil as the secondary and a regular radiofrequency (RF) coil as the primary. A third coil was positioned between the two coils for detuning during RF transmission. Bench measurement, numerical simulation, and MRI experiment were performed for validation. The signal-to-noise ratio of the proposed 2-in-1 coil is 35% higher in its field of view, compared with a MRI-only reference coil of the same size, made by the same material, and backed up by an untuned TMS coil, but lower than a RF surface coil of the same size without any TMS coil nearby. Spin-echo images of the human brain further validated its performance. The proposed method can transform TMS coil for MRI signal acquisition with virtually no modifications on the TMS side. It not only enables flexible and close positioning of TMS coil inside MRI scanner, but also improves the signal-to-noise ratio compared with conventional implementations. It can be applied as a building block for developing advanced concurrent TMS/MRI hardware. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  20. Computational analysis of residue contributions to coiled-coil topology.

    Ramos, Jorge; Lazaridis, Themis


    A variety of features are thought to contribute to the oligomeric and topological specificity of coiled coils. In previous work, we examined the determinants of oligomeric state. Here, we examine the energetic basis for the tendency of six coiled-coil peptides to align their α-helices in antiparallel orientation using molecular dynamics simulations with implicit solvation (EEF1.1). We also examine the effect of mutations known to disrupt the topology of these peptides. In agreement with experiment, ARG or LYS at a or d positions were found to stabilize the antiparallel configuration. The modeling suggests that this is not due to a-a' or d-d' repulsions but due to interactions with e' and g' residues. TRP at core positions also favors the antiparallel configuration. Residues that disfavor parallel dimers, such as ILE at d, are better tolerated in, and thus favor the antiparallel configuration. Salt bridge networks were found to be more stabilizing in the antiparallel configuration for geometric reasons: antiparallel helices point amino acid side chains in opposite directions. However, the structure with the largest number of salt bridges was not always the most stable, due to desolvation and configurational entropy contributions. In tetramers, the extent of stabilization of the antiparallel topology by core residues is influenced by the e' residue on a neighboring helix. Residues at b and c positions in some cases also contribute to stabilization of antiparallel tetramers. This work provides useful rules toward the goal of designing coiled coils with a well-defined and predictable three-dimensional structure.

  1. Analysis of quench in the NHMFL REBCO prototype coils for the 32 T Magnet Project

    Breschi, M.; Cavallucci, L.; Ribani, P. L.; Gavrilin, A. V.; Weijers, H. W.


    A 32 T all-superconductive magnet with high field REBCO inner coils is under development at the National High Magnetic Field Laboratory, Tallahassee, Florida, USA. As part of the development activity, two prototype coils with full scale radial dimensions and final design features, but with reduced axial length were constructed. The prototype coils consist of six dry-wound double pancakes modules with uninsulated conductor and insulated stainless steel cowind. Quench studies on one of the prototype coils at 4.2 K in self-field and in a background magnetic field of 15 T were performed by activating a set of quench protection heaters. In this paper, we present a numerical analysis of the experimental results of the quench tests of one of the prototype coils. The numerical analysis was carried out through a coupled electro-thermal FEM model developed at the University of Bologna. The model is based on the coupling with distributed contact resistances of the coil pancakes described as 2D elements. A homogenization procedure of the REBCO tape and other coil materials is presented, which allows reducing the number of degrees of freedom and the computational effort. The model is applied to the analysis of the current and voltage evolutions during the experimental quench tests on the prototype coil.

  2. Coil Design for High Misalignment Tolerant Inductive Power Transfer System for EV Charging

    Kafeel Ahmed Kalwar


    Full Text Available The inductive power transfer (IPT system for electric vehicle (EV charging has acquired more research interest in its different facets. However, the misalignment tolerance between the charging coil (installed in the ground and pick-up coil (mounted on the car chassis, has been a challenge and fundamental interest in the future market of EVs. This paper proposes a new coil design QDQ (Quad D Quadrature that maintains the high coupling coefficient and efficient power transfer during reasonable misalignment. The QDQ design makes the use of four adjacent circular coils and one square coil, for both charging and pick-up side, to capture the maximum flux at any position. The coil design has been modeled in JMAG software for calculation of inductive parameters using the finite element method (FEM, and its hardware has been tested experimentally at various misaligned positions. The QDQ coils are shown to be capable of achieving good coupling coefficient and high efficiency of the system until the misalignment displacement reaches 50% of the employed coil size.

  3. A twenty-eight channel coil array for improved optic nerve imaging

    Merrill, Robb Phillip

    The purpose of this work was to design and construct a radio-frequency coil optimized for imaging the Optic Nerve (ON) on a Siemens 3T magnetic resonance imaging (MRI) scanner. The specific goals were to optimize signal sensitivity from the orbit to the optic chiasm and improve SNR over designs currently in use. The constructed coil features two fiberglass formers that can slide over each other to accommodate any arbitrary head size, while maintaining close coupling near the eyes and around the head in general. This design eliminates the air void regions that occur between the coil elements and the forehead when smaller heads are imaged in one-piece, nonadjustable coil formers. The 28 coil elements were placed using a soccer-ball pattern layout to maximize head coverage. rSNR profiles from phantom imaging studies show that the ON coil provides approximately 55% greater rSNR at the region of the optic chiasm and approximately 400% near the orbits compared to the 12-channel commercial coil. The improved rSNR in the optic nerve region allows performance of high resolution DTI, which provides a qualitative measurement for evaluating optic neuritis. Images from volunteer and patient studies with the ON coil reveal plaques that correspond well with the patient disease history of chronic bilateral optic neuritis. Correspondence of image findings with patient disease histories demonstrates that optic neuritis can be visualized and detected in patients using 3T MRI with advanced imaging coils, providing improved patient care.

  4. Analysis of reflection-coefficient by wireless power transmission using superconducting coils

    Jeong, In Sung; Choi, Hyo Sang [Chosun University, Gwangju (Korea, Republic of); Chung, Dong Chul [Korea Institute of Carbon Convergence Technology, Jeonju (Korea, Republic of)


    The use of electronic devices such as mobile phones and tablet PCs has increased of late. However, the power which is supplied through wires has a limitation of the free use of devices and portability. Magnetic-resonance wireless power transfer (WPT) can achieve increased transfer distance and efficiency compared to the existing electromagnetic inductive coupling. A superconducting coil can be applied to increase the efficiency and distance of magnetic-resonance WPT. As superconducting coils have lower resistance than copper coils, they can increase the quality factor (Q-factor) and can overcome the limitations of magnetic-resonance WPT. In this study, copper coils were made from ordinary copper under the same condition as the superconducting coils for a comparison experiment. Superconducting coils use liquid nitrogen to keep the critical temperature. As there is a difference of medium between liquid nitrogen and air, liquid nitrogen was also used in the normal conductor coil to compare the experiment with under the same condition. It was confirmed that superconducting coils have a lower reflection-coefficient(S11) than the normal conductor coils.

  5. Quench absorption coils: a quench protection concept for high-field superconducting accelerator magnets

    Mentink, M.; Salmi, T.


    A quench protection concept based on coupled secondary coils is studied for inductively transferring energy out of a quenching superconducting dipole and thus limiting the peak hotspot temperature. So-called ‘quench absorption coils’ are placed in close proximity to the superconducting coils and are connected in series with a diode for the purpose of preventing current transformation during regular operation. During a quench, current is then transformed into the quench absorption coils so that a significant fraction of the stored magnetic energy is dissipated in the these coils. Numerical calculations are performed to determine the impact of such a concept and to evaluate the dimensions of the quench absorption coils needed to obtain significant benefits. A previously constructed 15 T Nb3Sn block coil is taken as a reference layout. Finite-element calculations are used to determine the combined inductive and thermal response of this system and these calculations are validated with a numerical model using an adiabatic approximation. The calculation results indicate that during a quench the presence of the quench absorption coils reduces the energy dissipated in the superconducting coils by 45% and reduces the hotspot temperature by over 100 K. In addition, the peak resistive voltage over the superconducting coils is significantly reduced. This suggests that this concept may prove useful for magnet designs in which the hotspot temperature is a design driver.

  6. Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice.

    Angélica Rueda

    Full Text Available Diabetes is a major risk factor for stroke. However, the molecular mechanisms involved in cerebral artery dysfunction found in the diabetic patients are not completely elucidated. In cerebral artery smooth muscle cells (CASMCs, spontaneous and local increases of intracellular Ca2+ due to the opening of ryanodine receptors (Ca2+ sparks activate large conductance Ca2+-activated K+ (BK channels that generate spontaneous transient outward currents (STOCs. STOCs have a key participation in the control of vascular myogenic tone and blood pressure. Our goal was to investigate whether alterations in Ca(2+ spark and STOC activities, measured by confocal microscopy and patch-clamp technique, respectively, occur in isolated CASMCs of an experimental model of type-2 diabetes (db/db mouse. We found that mean Ca(2+ spark amplitude, duration, size and rate-of-rise were significantly smaller in Fluo-3 loaded db/db compared to control CASMCs, with a subsequent decrease in the total amount of Ca(2+ released through Ca(2+ sparks in db/db CASMCs, though Ca(2+ spark frequency remained. Interestingly, the frequency of large-amplitude Ca(2+ sparks was also significantly reduced in db/db cells. In addition, the frequency and amplitude of STOCs were markedly reduced at all voltages tested (from -50 to 0 mV in db/db CASMCs. The latter correlates with decreased BK channel β1/α subunit ratio found in db/db vascular tissues. Taken together, Ca(2+ spark alterations lead to inappropriate BK channels activation in CASMCs of db/db mice and this condition is aggravated by the decrease in the BK β1 subunit/α subunit ratio which underlies the significant reduction of Ca(2+ spark/STOC coupling in CASMCs of diabetic animals.

  7. The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins

    Caillat, Christophe; Fish, Alexander [The Netherlands Cancer Institute, 1066 CX Amsterdam (Netherlands); Pefani, Dafni-Eleftheria; Taraviras, Stavros; Lygerou, Zoi [University of Patras, 26505 Rio, Patras (Greece); Perrakis, Anastassis, E-mail: [The Netherlands Cancer Institute, 1066 CX Amsterdam (Netherlands)


    The GemC1 coiled-coil structure has subtle differences compared with its homologues Geminin and Idas. Co-expression experiments in cells and biophysical stability analysis of the Geminin-family coiled coils suggest that the GemC1 coiled coil alone is unstable. GemC1, together with Idas and Geminin, an important regulator of DNA-replication licensing and differentiation decisions, constitute a superfamily sharing a homologous central coiled-coil domain. To better understand this family of proteins, the crystal structure of a GemC1 coiled-coil domain variant engineered for better solubility was determined to 2.2 Å resolution. GemC1 shows a less typical coiled coil compared with the Geminin homodimer and the Geminin–Idas heterodimer structures. It is also shown that both in vitro and in cells GemC1 interacts with Geminin through its coiled-coil domain, forming a heterodimer that is more stable that the GemC1 homodimer. Comparative analysis of the thermal stability of all of the possible superfamily complexes, using circular dichroism to follow the unfolding of the entire helix of the coiled coil, or intrinsic tryptophan fluorescence of a unique conserved N-terminal tryptophan, shows that the unfolding of the coiled coil is likely to take place from the C-terminus towards the N-terminus. It is also shown that homodimers show a single-state unfolding, while heterodimers show a two-state unfolding, suggesting that the dimer first falls apart and the helices then unfold according to the stability of each protein. The findings argue that Geminin-family members form homodimers and heterodimers between them, and this ability is likely to be important for modulating their function in cycling and differentiating cells.

  8. Towards Revised Step IV MICE Optics in the Absence of M1 SSD

    Bayes, R. [Univ. of Glasgow, Scotland (United Kingdom); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blackmore, V. [Imperial College, London (United Kingdom); Hunt, C. [Imperial College, London (United Kingdom); Liu, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pasternak, J. [Imperial College, London (United Kingdom); Rogers, C. T. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL)


    During magnet commissioning in September 2015, the leads on coil M1 of the downstream spectrometer solenoid failed. The coil will not be operational for MICE Step IV. Revised optics settings for the Step IV data taking are reviewed.

  9. Deformation of Linked Polymer Coils

    董朝霞; 李明远; 吴肇亮; 林梅钦


    Linked polymer solution (LPS) is defined as the solution of linked polymer coils (LPCs) dispersed in water, composed of low concentration partially hydrolyzed polyacrylamide (HPAM) and aluminum citrate (crosslinker). In the work, the conformational changes of LPCs under different conditions were investigated by the methods of membrane filtering under low pressure, dynamic light scattering and core flooding experiments. The results showed that in some conditions the LPCs could be compressed mechanically to 1/158.5 of their original volume because of relatively lower HPAM cross-linking. The hydration property of LPCs was similar to that of normal polymer coils. The deformation of LPCs was more restricted than that of ordinary polymer coils under the flow shear stress or the shift of hydration equilibrium caused in the variation of the electrolyte concentration which is responsible for the effective plugging in the throats of porous media when LPCs are used for deep diverting.

  10. Coil Optimization for HTS Machines

    Mijatovic, Nenad; Jensen, Bogi Bech; Abrahamsen, Asger Bech

    for different tape parameters Ici, ni and Ci, where Ici, ni and Ci are critical current, n - value and price of the ith tape respectively and i=1, 2, 3…, further optimization with respect to cost vs. HTS losses has been performed. Allowing for different types of HTS tapes in the coils, a guidance to which tape....... The proposed coil design is optimized with respect to minimizing the perpendicular field while still maximizing the amplitude of fundamental space harmonic. This guarantees the lowest HTS loss density and best utilization of expensive HTS material in the field winding of the SM. Additionally, accounting...

  11. Electromagnetic Gun With Commutated Coils

    Elliott, David G.


    Proposed electromagnetic gun includes electromagnet coil, turns of which commutated in sequence along barrel. Electrical current fed to two armatures by brushes sliding on bus bars in barrel. Interaction between armature currents and magnetic field from coil produces force accelerating armature, which in turn, pushes on projectile. Commutation scheme chosen so magnetic field approximately coincides and moves with cylindrical region defined by armatures. Scheme has disadvantage of complexity, but in return, enables designer to increase driving magnetic field without increasing armature current. Attainable muzzle velocity increased substantially.

  12. Electromagnetic flat sheet forming by spiral type actuator coil

    Akbar, S.; Aleem, M. A.; Sarwar, M. N.; Zillohu, A. U.; Awan, M. S.; Haider, A.; Ahmad, Z.; Akhtar, S.; Farooque, M.


    Focus of present work is to develop a setup for high strain rate electromagnetic forming of thin aluminum sheets (0.5, 1.0, 1.5 and 2.0 mm) and optimization of forming parameters. Flat spiral coil of 99.9% pure Cu strip (2.5x8.0 mm) with self-inductance 11 μH, 13 no. of turns and resultant outer diameter of 130mm has been fabricated and was coupled to a capacitor bank of energy, voltage and capacitance of 9 kJ, 900 V and 22.8 mF, respectively. To optimize the coil design, a commercially available software FEMM-4.2 was used to simulate the electromagnetic field profile generated by the coils of different pitch but same number of turns. Results of electromagnetic field intensity proposed by simulation agree in close proximity with those of theoretical as well as experimental data. The calculation of electromagnetic force and magnetic couplings between the coil and metal sheet are made. Forming parameters were optimized for different sheet thicknesses. Electromagnetic field intensity's profile plays a principal role in forming of typical shapes and patterns in sheets.

  13. [Two Cases of Ruptured Cerebral Aneurysm Complicated with Delayed Coil Protrusion after Coil Embolization].

    Furukawa, Takashi; Ogata, Atsushi; Ebashi, Ryo; Takase, Yukinori; Masuoka, Jun; Kawashima, Masatou; Abe, Tatsuya


    We report two cases of delayed coil protrusion after coil embolization for ruptured cerebral aneurysms. Case 1:An 82-year-old woman with a subarachnoid hemorrhage due to a ruptured small anterior communicating artery aneurysm underwent successful coil embolization. Eighteen days after the procedure, coil protrusion from the aneurysm into the right anterior cerebral artery was observed without any symptoms. Further coil protrusion did not develop after 28 days. Case 2:A 78-year-old woman with a subarachnoid hemorrhage due to a ruptured small left middle cerebral artery aneurysm underwent successful coil embolization. Twenty days after the procedure, coil protrusion from the aneurysm into the left middle cerebral artery was observed, with a transient ischemic attack. Further coil protrusion did not develop. Both patients recovered with antithrombotic treatment. Even though delayed coil protrusion after coil embolization is rare, it should be recognized as a long-term complication of coil embolization for cerebral aneurysms.

  14. Generalization of Helmholtz coil problem

    Petković Dejan M.


    Full Text Available The primary intent of this work is to propose a simple analytical method for designing coil systems for homogeneous and gradient magnetostatic field generation. Coil system consists of two identical coaxial (regular polygonal current loops. In the space between the loops, there is nearly homogeneous or nearly linear distribution of the magnetic field along the axes depending on the currents' direction. First, we derived a suitable, simple and general expression for the magnetic field along the axes due to a polygonal current loop. We emphasize the importance of the role of this expression for further analysis. The total on-axes magnetic field is the result of superposition of the magnetic fields that each loop generates separately. The proper distance between the loops and the current orientation make the system to become either Helmholtz coil or anti-Helmholtz coil. In this paper we give exact, analytical and general expression for this optimal distance that provides the magnetic field to be homogeneous (linear as much as possible. We based our study on Taylor series expansion of the total magnetic field, demanding that the first contaminating term must be canceled, in both, symmetric and asymmetric case.

  15. The intravenous injection of oxidized LDL- or Apolipoprotein B100 – Coupled splenocytes promotes Th1 polarization in wildtype and Apolipoprotein E – Deficient mice

    Steinmetz, Martin, E-mail: [INSERM, Unit 970, Paris Cardiovascular Research Center, 75015 Paris (France); Internal Medicine II, University Hospital Bonn, 53105 Bonn (Germany); Ponnuswamy, Padmapriya; Laurans, Ludivine; Esposito, Bruno; Tedgui, Alain [INSERM, Unit 970, Paris Cardiovascular Research Center, 75015 Paris (France); Mallat, Ziad [INSERM, Unit 970, Paris Cardiovascular Research Center, 75015 Paris (France); Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke' s Hospital, Cambridge, CB2 2QQ (United Kingdom)


    Background: Th1 responses in atherosclerosis are mainly associated with the aggravation of atherosclerotic plaques, whereas Th2 responses lead to a less pronounced disease in mouse models. The fixation of antigens on cells by means of ethylene carbodiimide (ECDI), and subsequent injection of these antigen-coupled splenocytes (Ag-SP) to induce tolerance against the attached antigens, has been successfully used to treat murine type 1 diabetes or encephalomyelitis in. We analyzed this approach in a mouse model for atherosclerosis. Methods and results: OTII-transgenic mice that were treated with a single dose of 5 × 10{sup 7} OVA-coupled splenocytes (OVA-SP), had decreased splenocyte proliferation, and lower IFNγ production in vitro upon antigen recall. However, in vivo CD4 cell activation was increased. To try lipoprotein-derived, “atherosclerosis-associated” antigens, we first tested human oxidized LDL. In wild type mice, an increase of IFNγ production upon in vitro recall was detected in the oxLDL-SP group. In Apolipoprotein E − deficient (ApoE−/−) mice that received oxLDL-SP every 5 weeks for 20 weeks, we did not find any difference of atherosclerotic plaque burden, but again increased IFNγ production. To overcome xenogenous limitations, we then examined the effects of mouse Apolipoprotein B100 peptides P3 and P6. ApoB100-SP treatment again promoted a more IFNγ pronounced response upon in vitro recall. Flow cytometry analysis of cytokine secreting spleen cells revealed CD4 positive T cells to be mainly the source for IFNγ. In ApoE−/− mice that were administered ApoB100-SP during 20 weeks, the atherosclerotic plaque burden in aortic roots as well as total aorta was unchanged compared to PBS treated controls. Splenocyte proliferation upon antigen recall was not significantly altered in ApoB100-SP treated ApoE−/− mice. Conclusion: Although we did not observe a relevant anti-atherosclerotic benefit, the treatment with antigen-coupled

  16. Transformer-coupled NMR probe

    Utsuzawa, Shin; Mandal, Soumyajit; Song, Yi-Qiao


    In this study, we propose an NMR probe circuit that uses a transformer with a ferromagnetic core for impedance matching. The ferromagnetic core provides a strong but confined coupling that result in efficient energy transfer between the sample coil and NMR spectrometer, while not disturbing the B1 field generated by the sample coil. We built a transformer-coupled NMR probe and found that it offers comparable performance (loss NQR.

  17. Rotor assembly including superconducting magnetic coil

    Snitchler, Gregory L. (Shrewsbury, MA); Gamble, Bruce B. (Wellesley, MA); Voccio, John P. (Somerville, MA)


    Superconducting coils and methods of manufacture include a superconductor tape wound concentrically about and disposed along an axis of the coil to define an opening having a dimension which gradually decreases, in the direction along the axis, from a first end to a second end of the coil. Each turn of the superconductor tape has a broad surface maintained substantially parallel to the axis of the coil.

  18. Physics design of a saddle coil system for TCV

    Rossel, J.X., E-mail:; Moret, J.-M.; Martin, Y.; Pochon, G.


    Highlights: Black-Right-Pointing-Pointer The design of a saddle coil system for TCV is presented. Black-Right-Pointing-Pointer The system is designed for ELM control, error field correction and vertical control. Black-Right-Pointing-Pointer The issue of optimal design determination is addressed. Black-Right-Pointing-Pointer Electrical properties in the presence of a conducting wall are quantified. Black-Right-Pointing-Pointer Coil heating due to Joule effect and impact of plasma disruptions are considered. - Abstract: The upgrade project for TCV (Tokamak a Configuration Variable) includes the installation of a set of saddle coils, namely the saddle coil system (SCS), located and powered such as to create a helical magnetic perturbation. Using independent power supplies, the toroidal periodicity of this perturbation is tunable, allowing simultaneously edge localized modes (ELM) control through resonant magnetic perturbation (RMP), error field correction and vertical control. Other experimental applications, like resistive wall mode and rotation control, are also in view. In this article, the adequacy of two SCS designs, an in-vessel one and an ex-vessel one, is assessed with respect to the desired experimental applications. The current requirements and the system performances are also characterized. The conducting vessel wall is accounted for in a model used to determine the coupled response functions of the SCS, the screening of the magnetic perturbation by the wall, the induced voltages and currents during a plasma disruption and the maximal magnetic forces exerted on the SCS. A scaling of the SCS parameters with the number of coil turns is presented and the issue of coil heating and cooling is discussed.

  19. Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif

    Céspedes, Nora; Habel, Catherine; Lopez-Perez, Mary


    Protein α-helical coiled coil structures that elicit antibody responses, which block critical functions of medically important microorganisms, represent a means for vaccine development. By using bioinformatics algorithms, a total of 50 antigens with α-helical coiled coil motifs orthologous...

  20. The many types of interhelical ionic interactions in coiled coils - an overview.

    Meier, Markus; Stetefeld, Jörg; Burkhard, Peter


    Coiled coils represent the most frequent protein oligomerization motif in nature and are involved in many important biological processes. The prototype interhelical ionic interaction for coiled coils described in literature is an i to i+5 ionic interaction from heptad position g to e', but other possible ionic interactions have also been described. Here we use a statistical approach to systematically analyze all high-quality coiled-coil structures in the RCSB protein database for their interhelical ionic interactions. We provide a complete listing of all possible arrangements and analyze the frequency of their occurrence in the primary sequence together with their probability of formation in the quaternary structure of the coiled coils. We show that the classical i to i+5 ionic interaction is indeed characteristic for parallel dimeric and trimeric coiled coils. But we also show that there are many more i to i+2 ionic interactions in parallel tetrameric and pentameric coiled coils, and in antiparallel coiled coils the classical i to i+5 ionic interaction is in none of the oligomerizations states the most frequently observed ionic interaction. We also demonstrate that many ionic interactions involve residues at the core positions that are usually occupied by hydrophobic residues and that such interhelical ionic interactions are a hallmark feature of dimeric coiled coils.

  1. Design of a shielded coil element of a matrix gradient coil

    Jia, Feng; Littin, Sebastian; Layton, Kelvin J.; Kroboth, Stefan; Yu, Huijun; Zaitsev, Maxim


    The increasing interest in spatial encoding with non-linear magnetic fields has intensified the need for coils that generates such fields. Matrix coils consisting of multiple coil elements appear to offer a high flexibility in generating customized encoding fields and are particularly promising for localized high resolution imaging applications. However, coil elements of existing matrix coils were primarily designed and constructed for better shimming and therefore are not expected to achieve an optimal performance for local spatial encoding. Moreover, eddy current properties of such coil elements were not fully explored. In this work, an optimization problem is formulated based on the requirement of local non-linear encoding and eddy current reduction that results in novel designs of coil elements for an actively-shielded matrix gradient coil. Two metrics are proposed to assess the performance of different coil element designs. The results are analyzed to reveal new insights into coil element design.

  2. Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins.

    Rose, A; Meier, I


    Long alpha-helical coiled-coil proteins are involved in a variety of organizational and regulatory processes in eukaryotic cells. They provide cables and networks in the cyto- and nucleoskeleton, molecular scaffolds that organize membrane systems, motors, levers, rotating arms and possibly springs. A growing number of human diseases are found to be caused by mutations in long coiled-coil proteins. This review summarizes our current understanding of the multifaceted group of long coiled-coil proteins in the cytoskeleton, nucleus, Golgi and cell division apparatus. The biophysical features of coiled-coil domains provide first clues toward their contribution to the diverse protein functions and promise potential future applications in the area of nanotechnology. Combining the power of fully sequenced genomes and structure prediction algorithms, it is now possible to comprehensively summarize and compare the complete inventory of coiled-coil proteins of different organisms.

  3. Repeats in transforming acidic coiled-coil (TACC) genes.

    Trivedi, Seema


    Transforming acidic coiled-coil proteins (TACC1, 2, and 3) are essential proteins associated with the assembly of spindle microtubules and maintenance of bipolarity. Dysregulation of TACCs is associated with tumorigenesis, but studies of microsatellite instability in TACC genes have not been extensive. Microsatellite or simple sequence repeat instability is known to cause many types of cancer. The present in silico analysis of SSRs in human TACC gene sequences shows the presence of mono- to hexa-nucleotide repeats, with the highest densities found for mono- and di-nucleotide repeats. Density of repeats is higher in introns than in exons. Some of the repeats are present in regulatory regions and retained introns. Human TACC genes show conservation of many repeat classes. Microsatellites in TACC genes could be valuable markers for monitoring numerical chromosomal aberrations and or cancer.

  4. Simplified approach of predictions of thermal performance for counterflow fully-wet cooling coil

    Mansour, M. Khamis; Hassab, M. A.


    An innovative correlation associating the effectiveness (ɛ) of the fully-wet cooling coil with its number of transfer unit and vice versa is presented in this work. The thermal performance and design of fully-wet cooling coil can be predicted simply through those correlations. The analytical model was constructed on a basis of solving heat and mass transfer equation "enthalpy potential method" simultaneously coupled with the energy equations. The validity of the new correlations was tested by experimental reported in the available literature. A good agreement with deviation less than 10% was found during the comparison between the output results of the new correlations and those obtained from the literature. The main benefits of those new correlations (1) Its simplicity to be implemented through simple calculations of input parameters (2) It provides helpful guidelines for optimization of wet cooling coil performance during its operation coupling with the thermal system at which the coil is integrated.

  5. Numerical and experimental analysis of harmonic distortion in a moving-coil loudspeaker

    Chang, Chun; Wang, Chi-Chang; Shiah, Y. C.; Huang, Jin H.


    The nonlinear effect of a moving-coil loudspeaker, originating from its magnetic coupling factor and the system's stiffness, presents a significant impact on the sound quality. For improving the sound quality, this article proposes an approach to reduce the total harmonic distortion (THD) by adjusting the initial position of its voice-coil. First, a mathematical model involving the nonlinearities of force factor, mechanical stiffness, and inductance of voice coil is constructed and then solved using a novel algorithm called the parameter spline difference method (PSD). In the course of pursuing reduction of the corresponding THD of a typical moving-coil loudspeaker, the model was used to analyze the nonlinearity of the THD, revealing itself as a nonlinear function of force factor, the system's stiffness and inductance of voice coil. For various initial positions of the voice-coil, the coupled nonlinear differential equations were solved using the PSD to yield corresponding sound pressure level and THD. To our satisfaction, the loudspeaker driver with its voice-coil optimally tuned for the initial position turns out to have a THD reduction of 10%, which is also consistent with our experimental observations.

  6. Micro fluxgate magnetic sensors using planar coils wrapped around a film core

    Kawahito, S.; Suto, M.; Yamasawa, A.; Tadokoro, Y. [Toyohashi University of Technology, Aichi (Japan)


    This paper presents highly-sensitive fluxgate magnetic sensors based on silicon microtechnology and electrodeposited magnetic thin films. To achieve high sensitivity, we propose a coil structure that both the excitation and the pickup coils are wrapped around a thin-film core. The optimal coupling structure between excitation and pickup coils is investigated. The closely-coupled coil structure that a one turn of excitation coil and a few turns of pick-up coil are wound alternatively around the magnetic core is effective to achieve high sensitivity. In general, the magnetic performance of the core prepared by electrodeposition is degraded due to the thermal treatment process during the fabrication. The addition of indium in the plating bath of Permalloy greatly reduces the degradation of magnetic core due to the thermal treatment process. An improved basic micro fluxgate sensing element chip employing new-type coil structures and the indium-added permalloy prepared by electrodeposition is fabricated. The maximum sensitivity of the fabricated sensor is measured to be 2700V/T at the excitation frequency of 3MHz. The noise spectral density is measured to be 0.6nT/Hz at 10Hz. 24 refs., 11 figs., 1 tab.

  7. Coil Migration through a Neuroform 3 Stent during Endovascular Coiling. A Case Report.

    O'Hare, A


    Summary: A 43-year-old woman attended for stent assisted coiling. A Neuroform 30 x 4.5 mm stent had been successfully placed over the left periophthalmic aneurysm. During the coiling the first coil migrated through the crowns in the stent, lodging at the MCA bifurcation. We believe that the coil herniated through the overlying stent due to the carotid siphon curvature and the open cell design. Furthermore the distal markers of the stent impeded coil extraction with a MERCI device.

  8. Determining the Frequency for Load-Independent Output Current in Three-Coil Wireless Power Transfer System

    Longzhao Sun


    Full Text Available Conditions for load-independent output voltage or current in two-coil wireless power transfer (WPT systems have been studied. However, analysis of load-independent output current in three-coil WPT system is still lacking in previous studies. This paper investigates the output current characteristics of a three-coil WPT system against load variations, and determines the operating frequency to achieve a constant output current. First, a three-coil WPT system is modeled by circuit theory, and the analytical expression of the root-mean-square of the output current is derived. By substituting the coupling coefficients, the quality factor, and the resonant frequency of each coil, we propose a method of calculating the frequency for load-independent output current in a three-coil WPT system, which indicates that there are two frequencies that can achieve load-independent output current. Experiments are conducted to validate these analytical results.

  9. Performance evaluation of matrix gradient coils.

    Jia, Feng; Schultz, Gerrit; Testud, Frederik; Welz, Anna Masako; Weber, Hans; Littin, Sebastian; Yu, Huijun; Hennig, Jürgen; Zaitsev, Maxim


    In this paper, we present a new performance measure of a matrix coil (also known as multi-coil) from the perspective of efficient, local, non-linear encoding without explicitly considering target encoding fields. An optimization problem based on a joint optimization for the non-linear encoding fields is formulated. Based on the derived objective function, a figure of merit of a matrix coil is defined, which is a generalization of a previously known resistive figure of merit for traditional gradient coils. A cylindrical matrix coil design with a high number of elements is used to illustrate the proposed performance measure. The results are analyzed to reveal novel features of matrix coil designs, which allowed us to optimize coil parameters, such as number of coil elements. A comparison to a scaled, existing multi-coil is also provided to demonstrate the use of the proposed performance parameter. The assessment of a matrix gradient coil profits from using a single performance parameter that takes the local encoding performance of the coil into account in relation to the dissipated power.

  10. Starch gelatinization in coiled heaters.

    Kelder, J D H; Ptasinski, K J; Kerkhof, P J A M


    A gelatinizing model food derived from a 5% w/w cross-linked waxy maize starch suspension was simulated in coiled heaters to assess the impact of centrifugal forces on flow and heat transfer. For four coil diameters (D = 0.25, 1, 2.5, and infinity m) and three flow rates (w = 0.5, 1, and 2 m/s), heat transfer, viscous development, and the severity of channeling were evaluated. Increasing curvature proved to suppress channeling as a result of more uniform heating and gelatinization. The maximum attainable viscosity was also higher, implying a lower starch consumption for a target viscosity. Higher flow rates necessitated longer heaters, and the maximum viscosity decreased. Moderate product velocities are therefore recommended.

  11. An improved trap design for decoupling multinuclear RF coils.

    Meyerspeer, Martin; Serés Roig, Eulalia; Gruetter, Rolf; Magill, Arthur W


    Multinuclear magnetic resonance spectroscopy and imaging require a radiofrequency probe capable of transmitting and receiving at the proton and non-proton frequencies. To minimize coupling between probe elements tuned to different frequencies, LC (inductor-capacitor) traps blocking current at the (1)H frequency can be inserted in non-proton elements. This work compares LC traps with LCC traps, a modified design incorporating an additional capacitor, enabling control of the trap reactance at the low frequency while maintaining (1)H blocking. Losses introduced by both types of trap were analysed using circuit models. Radiofrequency coils incorporating a series of LC and LCC traps were then built and evaluated at the bench. LCC trap performance was then confirmed using (1)H and (13)C measurements in a 7T human scanner. LC and LCC traps both effectively block interaction between non-proton and proton coils at the proton frequency. LCC traps were found to introduce a sensitivity reduction of 5±2%, which was less than half of that caused by LC traps. Sensitivity of non-proton coils is critical. The improved trap design, incorporating one extra capacitor, significantly reduces losses introduced by the trap in the non-proton coil. Copyright © 2013 Wiley Periodicals, Inc.

  12. Coiled transmission line pulse generators

    McDonald, Kenneth Fox (Columbia, MO)


    Methods and apparatus are provided for fabricating and constructing solid dielectric "Coiled Transmission Line" pulse generators in radial or axial coiled geometries. The pour and cure fabrication process enables a wide variety of geometries and form factors. The volume between the conductors is filled with liquid blends of monomers, polymers, oligomers, and/or cross-linkers and dielectric powders; and then cured to form high field strength and high dielectric constant solid dielectric transmission lines that intrinsically produce ideal rectangular high voltage pulses when charged and switched into matched impedance loads. Voltage levels may be increased by Marx and/or Blumlein principles incorporating spark gap or, preferentially, solid state switches (such as optically triggered thyristors) which produce reliable, high repetition rate operation. Moreover, these Marxed pulse generators can be DC charged and do not require additional pulse forming circuitry, pulse forming lines, transformers, or an a high voltage spark gap output switch. The apparatus accommodates a wide range of voltages, impedances, pulse durations, pulse repetition rates, and duty cycles. The resulting mobile or flight platform friendly cylindrical geometric configuration is much more compact, light-weight, and robust than conventional linear geometries, or pulse generators constructed from conventional components. Installing additional circuitry may accommodate optional pulse shape improvements. The Coiled Transmission Lines can also be connected in parallel to decrease the impedance, or in series to increase the pulse length.

  13. ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.

    Held, Richard G; Liu, Changliang; Kaeser, Pascal S


    In a presynaptic nerve terminal, synaptic strength is determined by the pool of readily releasable vesicles (RRP) and the probability of release (P) of each RRP vesicle. These parameters are controlled at the active zone and vary across synapses, but how such synapse specific control is achieved is not understood. ELKS proteins are enriched at vertebrate active zones and enhance P at inhibitory hippocampal synapses, but ELKS functions at excitatory synapses are not known. Studying conditional knockout mice for ELKS, we find that ELKS enhances the RRP at excitatory synapses without affecting P. Surprisingly, ELKS C-terminal sequences, which interact with RIM, are dispensable for RRP enhancement. Instead, the N-terminal ELKS coiled-coil domains that bind to Liprin-α and Bassoon are necessary to control RRP. Thus, ELKS removal has differential, synapse-specific effects on RRP and P, and our findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.

  14. High performance 3-coil wireless power transfer system for the 512-electrode epiretinal prosthesis.

    Zhao, Yu; Nandra, Mandheerej; Yu, Chia-Chen; Tai, Yu-chong


    The next-generation retinal prostheses feature high image resolution and chronic implantation. These features demand the delivery of power as high as 100 mW to be wireless and efficient. A common solution is the 2-coil inductive power link, used by current retinal prostheses. This power link tends to include a larger-size extraocular receiver coil coupled to the external transmitter coil, and the receiver coil is connected to the intraocular electrodes through a trans-sclera trans-choroid cable. In the long-term implantation of the device, the cable may cause hypotony (low intraocular pressure) and infection. However, when a 2-coil system is constructed from a small-size intraocular receiver coil, the efficiency drops drastically which may induce over heat dissipation and electromagnetic field exposure. Our previous 2-coil system achieved only 7% power transfer. This paper presents a fully intraocular and highly efficient wireless power transfer system, by introducing another inductive coupling link to bypass the trans-sclera trans-choroid cable. With the specific equivalent load of our customized 512-electrode stimulator, the current 3-coil inductive link was measured to have the overall power transfer efficiency around 36%, with 1-inch separation in saline. The high efficiency will favorably reduce the heat dissipation and electromagnetic field exposure to surrounding human tissues. The effect of the eyeball rotation on the power transfer efficiency was investigated as well. The efficiency can still maintain 14.7% with left and right deflection of 30 degree during normal use. The surgical procedure for the coils' implantation into the porcine eye was also demonstrated.

  15. Self-correction coil: operation mechanism of self-correction coil

    Hosoyama, K.


    We discuss here the operation mechanism of self-correction coil with a simple model. At the first stage, for the ideal self-correction coil case we calculate the self-inductance L of self-correction coil, the mutual inductance M between the error field coil and the self-correction coil, and using the model the induced curent in the self-correction coil by the external magnetic error field and induced magnetic field by the self-correction coil. And at the second stage, we extend this calculation method to non-ideal self-correction coil case, there we realize that the wire distribution of self-correction coil is important to get the high enough self-correction effect. For measure of completeness of self-correction effect, we introduce the efficiency eta of self-correction coil by the ratio of induced magnetic field by the self-correction coil and error field. As for the examples, we calculate L, M and eta for two cases; one is a single block approximation of self-correction coil winding and the other is a two block approximation case. By choosing the adequate angles of self-correction coil winding, we can get about 98% efficiency for single block approximation case and 99.8% for two block approximation case. This means that by using the self-correction coil we can improve the field quality about two orders.

  16. Coiled-coil protein composition of 22 proteomes – differences and common themes in subcellular infrastructure and traffic control

    Meier Iris


    Full Text Available Abstract Background Long alpha-helical coiled-coil proteins are involved in diverse organizational and regulatory processes in eukaryotic cells. They provide cables and networks in the cyto- and nucleoskeleton, molecular scaffolds that organize membrane systems and tissues, motors, levers, rotating arms, and possibly springs. Mutations in long coiled-coil proteins have been implemented in a growing number of human diseases. Using the coiled-coil prediction program MultiCoil, we have previously identified all long coiled-coil proteins from the model plant Arabidopsis thaliana and have established a searchable Arabidopsis coiled-coil protein database. Results Here, we have identified all proteins with long coiled-coil domains from 21 additional fully sequenced genomes. Because regions predicted to form coiled-coils interfere with sequence homology determination, we have developed a sequence comparison and clustering strategy based on masking predicted coiled-coil domains. Comparing and grouping all long coiled-coil proteins from 22 genomes, the kingdom-specificity of coiled-coil protein families was determined. At the same time, a number of proteins with unknown function could be grouped with already characterized proteins from other organisms. Conclusion MultiCoil predicts proteins with extended coiled-coil domains (more than 250 amino acids to be largely absent from bacterial genomes, but present in archaea and eukaryotes. The structural maintenance of chromosomes proteins and their relatives are the only long coiled-coil protein family clearly conserved throughout all kingdoms, indicating their ancient nature. Motor proteins, membrane tethering and vesicle transport proteins are the dominant eukaryote-specific long coiled-coil proteins, suggesting that coiled-coil proteins have gained functions in the increasingly complex processes of subcellular infrastructure maintenance and trafficking control of the eukaryotic cell.

  17. Ground energy coupling

    Metz, P. D.

    The feasibility of ground coupling for various heat pump systems was investigated. Analytical heat flow models were developed to approximate design ground coupling devices for use in solar heat pump space conditioning systems. A digital computer program called GROCS (GRound Coupled Systems) was written to model 3-dimensional underground heat flow in order to simulate the behavior of ground coupling experiments and to provide performance predictions which have been compared to experimental results. GROCS also has been integrated with TRNSYS. Soil thermal property and ground coupling device experiments are described. Buried tanks, serpentine earth coils in various configurations, lengths and depths, and sealed vertical wells are being investigated. An earth coil used to heat a house without use of resistance heating is described.

  18. Mosquito coil emissions and health implications.

    Liu, Weili; Zhang, Junfeng; Hashim, Jamal H; Jalaludin, Juliana; Hashim, Zailina; Goldstein, Bernard D


    Burning mosquito coils indoors generates smoke that can control mosquitoes effectively. This practice is currently used in numerous households in Asia, Africa, and South America. However, the smoke may contain pollutants of health concern. We conducted the present study to characterize the emissions from four common brands of mosquito coils from China and two common brands from Malaysia. We used mass balance equations to determine emission rates of fine particles (particulate matter pollutant concentrations resulting from burning mosquito coils could substantially exceed health-based air quality standards or guidelines. Under the same combustion conditions, the tested Malaysian mosquito coils generated more measured pollutants than did the tested Chinese mosquito coils. We also identified a large suite of volatile organic compounds, including carcinogens and suspected carcinogens, in the coil smoke. In a set of experiments conducted in a room, we examined the size distribution of particulate matter contained in the coil smoke and found that the particles were ultrafine and fine. The findings from the present study suggest that exposure to the smoke of mosquito coils similar to the tested ones can pose significant acute and chronic health risks. For example, burning one mosquito coil would release the same amount of PM(2.5) mass as burning 75-137 cigarettes. The emission of formaldehyde from burning one coil can be as high as that released from burning 51 cigarettes.

  19. Investigation of biodistribution behavior of platinum particles in mice: Correlation between inductively coupled plasma-atomic emission spectroscopy and X-ray scanning analytical microscopy

    Abe, Shigeaki, E-mail: [Graduate School of Dental Medicine, Hokkaido University, Sapporo (Japan); Koyama, Chika; Mutoh, Mami [Faculty of Dental Medicine, Hokkaido University, Sapporo (Japan); Akasaka, Tsukasa [Graduate School of Dental Medicine, Hokkaido University, Sapporo (Japan); Uo, Motohiro [Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Watari, Fumio [Graduate School of Dental Medicine, Hokkaido University, Sapporo (Japan)


    Highlights: Black-Right-Pointing-Pointer We investigated the biodistribution of platinum microparticles in mice. Black-Right-Pointing-Pointer The biodistribution behavior was observed using inductively coupled plasma-atomic emission spectroscopy (ICP) and scanning X-ray analytical microscopy (XSAM). Black-Right-Pointing-Pointer The administered particles quickly reached in spleen, liver and lung with constant ration. Black-Right-Pointing-Pointer We also estimated the correlation ship between XSAM and ICP measurement. Black-Right-Pointing-Pointer The relative ratio of XSAM intensity showed highly correlation with the relative ratio of Pt concentration in organs. - Abstract: In this study, we investigated the biodistribution of platinum (Pt) microparticles in mice. The particles were administered through the tail vein, and then the biodistribution behavior was observed using inductively coupled plasma-atomic emission spectroscopy (ICP) and scanning X-ray analytical microscopy (XSAM). The administered particles quickly reached the spleen, liver, and lung at a constant ratio, and the ratio remained constant for four weeks. We also estimated the correlation between XSAM and ICP measurement. The relative ratio of XSAM intensity showed strong correlation with the relative ratio of Pt concentration in organs.

  20. The coiled coils of cohesin are conserved in animals, but not in yeast.

    Glenn E White

    Full Text Available BACKGROUND: The SMC proteins are involved in DNA repair, chromosome condensation, and sister chromatid cohesion throughout Eukaryota. Long, anti-parallel coiled coils are a prominent feature of SMC proteins, and are thought to serve as spacer rods to provide an elongated structure and to separate domains. We reported recently that the coiled coils of mammalian condensin (SMC2/4 showed moderate sequence divergence (approximately 10-15% consistent with their functioning as spacer rods. The coiled coils of mammalian cohesins (SMC1/3, however, were very highly constrained, with amino acid sequence divergence typically <0.5%. These coiled coils are among the most highly conserved mammalian proteins, suggesting that they make extensive contacts over their entire surface. METHODOLOGY/PRINCIPAL FINDINGS: Here, we broaden our initial analysis of condensin and cohesin to include additional vertebrate and invertebrate organisms and multiple species of yeast. We found that the coiled coils of SMC1/3 are highly constrained in Drosophila and other insects, and more generally across all animal species. However, in yeast they are no more constrained than the coils of SMC2/4 and Ndc80/Nuf2p, suggesting that they are serving primarily as spacer rods. CONCLUSIONS/SIGNIFICANCE: SMC1/3 functions for sister chromatid cohesion in all species. Since its coiled coils apparently serve only as spacer rods in yeast, it is likely that this is sufficient for sister chromatid cohesion in all species. This suggests an additional function in animals that constrains the sequence of the coiled coils. Several recent studies have demonstrated that cohesin has a role in gene expression in post-mitotic neurons of Drosophila, and other animal cells. Some variants of human Cornelia de Lange Syndrome involve mutations in human SMC1/3. We suggest that the role of cohesin in gene expression may involve intimate contact of the coiled coils of SMC1/3, and impose the constraint on sequence

  1. Optimum coil insertion speed of various coils in brain aneurysm embolization in vitro.

    Konishi, Yoshifumi; Takeuchi, Masataka; Fukasaku, Kazuaki


    A coil must comprise material with shape memory to perform optimal coil embolization. To achieve this, the alloy characteristics of the coil (hardness, shape, and thickness) must be understood. In this experiment, a catheter was fixed in the bright position and the movement of the coil was observed under a constant rate of insertion; the optimal insertion rate during clinical use was investigated. The first coil insertion speed was evaluated using simulated aneurysms in an in vivo arterial model. The results showed that the insertion force relates to the deployment shape of the coil, that the feedback through the force indicator using sound is very effective, and that the recorder is useful for analysis of coil embolization. The inserted coils during aneurysm embolization were able to wind uniformly within the aneurysm due to a variety of factors (guiding or micro-catheter position and kick-back phenomenon such as delivery wire). Optimal speed is achieved with proper coil design, which allows the coil to be inserted into the aneurysm. The shape and size of the aneurysm can help determine the necessary size and design of the coil that should be used during the optimal speed range. Aneurysm wall and coil characteristics are considered, along with the friction state of the coil (hardness, shape, and thickness), leading to improvements in safety during the insertion procedure at optimum speed.

  2. On the analysis of using 3-coil wireless power transfer system in retinal prosthesis.

    Bai, Shun; Skafidas, Stan


    Designing a wireless power transmission system(WPTS) using inductive coupling has been investigated extensively in the last decade. Depending on the different configurations of the coupling system, there have been various designing methods to optimise the power transmission efficiency based on the tuning circuitry, quality factor optimisation and geometrical configuration. Recently, a 3-coil WPTS was introduced in retinal prosthesis to overcome the low power transferring efficiency due to low coupling coefficient. Here we present a method to analyse this 3-coil WPTS using the S-parameters to directly obtain maximum achievable power transferring efficiency. Through electromagnetic simulation, we brought a question on the condition of improvement using 3-coil WPTS in powering retinal prosthesis.

  3. Unusually Stable Helical Coil Allotrope of Phosphorus.

    Liu, Dan; Guan, Jie; Jiang, Jingwei; Tománek, David


    We have identified an unusually stable helical coil allotrope of phosphorus. Our ab initio density functional theory calculations indicate that the uncoiled, isolated straight one-dimensional chain is equally stable as a monolayer of black phosphorus dubbed phosphorene. The coiling tendency and the attraction between adjacent coil segments add an extra stabilization energy of ∼12 meV/atom to the coil allotrope, similar in value to the ∼16 meV/atom interlayer attraction in bulk black phosphorus. Thus, the helical coil structure is essentially as stable as black phosphorus, the most stable phosphorus allotrope known to date. With an optimum radius of 2.4 nm, the helical coil of phosphorus may fit well and even form inside wide carbon nanotubes.

  4. The Golgin Family of Coiled-Coil Tethering Proteins

    Tomasz M Witkos


    Full Text Available The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an evolutionary conserved function. Golgins are anchored to the Golgi membrane by their carboxy terminus and are predicted to adopt an extended conformation that projects into the surrounding cytoplasm. This arrangement is ideal for the capture or tethering of nearby membranes or cytoskeletal elements. Golgin-mediated tethering is thought to be important for vesicular traffic at the Golgi apparatus, the maintenance of Golgi architecture, as well as the positioning of the Golgi apparatus within cells. In addition to acting as tethers, some golgins can also sequester various factors at the Golgi membrane, allowing for the spatiotemporal regulation of downstream cellular functions. Although it is now established that golgins are membrane and cytoskeleton tethers, the mechanisms underlying tethering remain poorly defined. Moreover, the importance of golgin-mediated tethering in a physiological context remains to be fully explored. This review will describe our current understanding of golgin function, highlighting recent progress that has been made, and goes on to discuss outstanding questions and potential avenues for future research with regard to this family of conserved Golgi-associated proteins.

  5. Force modulated conductance of artificial coiled-coil protein monolayers.

    Atanassov, Alexander; Hendler, Ziv; Berkovich, Inbal; Ashkenasy, Gonen; Ashkenasy, Nurit


    Studies of charge transport through proteins bridged between two electrodes have been the subject of intense research in recent years. However, the complex structure of proteins makes it difficult to elucidate transport mechanisms, and the use of simple peptide oligomers may be an over simplified model of the proteins. To bridge this structural gap, we present here studies of charge transport through artificial parallel coiled-coil proteins conducted in dry environment. Protein monolayers uniaxially oriented at an angle of ∼ 30° with respect to the surface normal were prepared. Current voltage measurements, obtained using conductive-probe atomic force microscopy, revealed the mechano-electronic behavior of the protein films. It was found that the low voltage conductance of the protein monolayer increases linearly with applied force, mainly due to increase in the tip contact area. Negligible compression of the films for loads below 26 nN allowed estimating a tunneling attenuation factor, β(0) , of 0.5-0.6 Å(-1) , which is akin to charge transfer by tunneling mechanism, despite the comparably large charge transport distance. These studies show that mechano-electronic behavior of proteins can shed light on their complex charge transport mechanisms, and on how these mechanisms depend on the detailed structure of the proteins. Such studies may provide insightful information on charge transfer in biological systems.

  6. Electrophoresis of a DNA Coil Near a Nanopore

    Rowghanian, Payam


    Motivated by DNA electrophoresis near a nanopore, we consider the flow field around an "elongated jet", a long thin source which injects momentum into a liquid. This solution qualitatively describes the electro-osmotic flow around a long rigid polymer, where due to electrohydrodynamic coupling, the solvent receives momentum from the electric field. Based on the qualitative behavior of the elongated jet solution, we develop a coarse-grained scheme which reproduces the known theoretical results regarding the electrophoretic behavior of a long rigid polymer and a polymer coil in a uniform field, which we then exploit to analyze the electrophoresis of a polymer coil in the non-uniform field near a nanopore.

  7. The proposal and realization on more exact modeling of COIL performance

    Shouxian; Li; Xiaojian; Shu; Yanyi; Du; Hua; Su; Yan; Li; Zhen; Yu


    The chemical oxygen–iodine laser(COIL)is the shortest-wavelength high-power chemical laser that has been demonstrated.The characteristics,such as good atmospheric propagation,short wavelength and excellent transmission through optical fibers,make the COIL a good candidate for high-power laser application.To model the complete COIL lasing interaction,a three-dimensional formulation of the fluid dynamics,species continuity and radiation transport equations is necessary.The computational effort to calculate the flow field over the entire nozzle bank with a grid fine enough to resolve the injection holes is so large as to preclude doing the calculation.The approach to modeling chemical lasers then has been to reduce the complexity of the model to correspond to the available computational capability,adding details as computing power increased.The modeling of lasing in the COIL medium is proposed,which is coupling with the effects induced by transverse injection of secondary gases,non-equilibrium chemical reactions,nozzle tail flow and boundary layer.The coupled steady solutions of the fluid dynamics and optics in a COIL complex three-dimensional cavity flow field are obtained following the proposal.The modeling results show that these effects have some influence on the lasing properties.A feasible methodology and a theoretical tool are offered to predict the beam quality for large-scale COIL devices.

  8. An Experimental Study on Constraint Cooling Process of Hot-rolled CoilS

    Lijuan WANG; Chunli ZHANG


    In order to master mechanical property, surface quality and microstructure of constraint cooling (CC) coils undervarious water cooling parameters, more than 100 coils cooling experiments were done with real production process,of which is designed a coolin

  9. Transport vesicle tethering at the trans Golgi network: coiled coil proteins in action

    Pak-yan Patricia Cheung


    Full Text Available The Golgi complex is decorated with so-called Golgin proteins that share a common feature: a large proportion of their amino acid sequences are predicted to form coiled-coil structures. The possible presence of extensive coiled coils implies that these proteins are highly elongated molecules that can extend a significant distance from the Golgi surface. This property would help them to capture or trap inbound transport vesicles and to tether Golgi mini-stacks together. This review will summarize our current understanding of coiled coil tethers that are needed for the receipt of transport vesicles at the trans Golgi network. How do long tethering proteins actually catch vesicles? Golgi-associated, coiled coil tethers contain numerous binding sites for small GTPases, SNARE proteins, and vesicle coat proteins. How are these interactions coordinated and are any or all of them important for the tethering process? Progress towards understanding these questions and remaining, unresolved mysteries will be discussed.

  10. Measurement of stapes vibration in Human temporal bones by round window stimulation using a 3-coil transducer.

    Shin, Dong Ho; Kim, Dong Wook; Lim, Hyung Gyu; Jung, Eui Sung; Seong, Ki Woong; Lee, Jyung Hyun; Kim, Myoung Nam; Cho, Jin Ho


    Round window placement of a 3-coil transducer offers a new approach for coupling an implantable hearing aid to the inner ear. The transducer exhibits high performance at low-frequencies. One remarkable feature of the 3-coil transducer is that it minimizes leakage flux. Thus, the transducer, which consists of two permanent magnets and three coils, can enhance vibrational displacement. In human temporal bones, stapes vibration was observed by laser Doppler vibrometer in response to round window stimulation using the 3-coil transducer. Coupling between the 3-coil transducer and the round window was connected by a wire-rod. The stimulation created stapes velocity when the round window stimulated. Performance evaluation was conducted by measuring stapes velocity. To verify the performance of the 3-coil transducer, stapes velocity for round window and tympanic membrane stimulation were compared, respectively. Stapes velocity by round window stimulation using the 3-coil transducer was approximately 14 dB higher than that achieved by tympanic membrane stimulation. The study shows that 3-coil transducer is suitable for implantable hearing aids.

  11. A novel method for coil efficiency estimation: Validation with a 13C birdcage

    Giovannetti, Giulio; Frijia, Francesca; Hartwig, Valentina;


    -to-noise ratio. In this work, we propose a novel method for RF coil efficiency estimation based on the use of a perturbing loop. The proposed method consists of loading the coil with a known resistor by inductive coupling and measuring the quality factor with and without the load. We tested the method...... by measuring the efficiency of a 13C birdcage coil tuned at 32.13 MHz and verified its accuracy by comparing the results with the nuclear magnetic resonance nutation experiment. The method allows coil performance characterization in a short time and with great accuracy, and it can be used both on the bench...... and inside the scanner. (c) 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 41B: 139143, 2012...

  12. The Effect of a Helix-Coil Transition on the Extension Elasticity

    Buhot, Arnaud; Halperin, Avi


    The secondary structure of a polymer affects its deformation behavior in accordance with the Le Chatelier principle. An important example of such secondary structure is the alpha helix encountered in polypeptides. Similar structure was recently proposed for PEO in aqueous media. Our discussion concerns the coupling of the cooperative helix-coil transition and the extension elasticity. In particular, we analyze the extension of a long single chain by use of optical tweezers or AFM. We consider chains that exist in the coil-state when unperturbed. The transition nevertheless occurs because the extension favors the low entropy helical state. As a result, the corresponding force law exhibits a plateau. The analysis of this situation involves two ingredients: (I) the stretching free energy penalty for a rod-coil mutiblock copolymer (II) the entropy associated with the possible placements of the rod and coil blocks.

  13. Effect of Inductive Coil Geometry and Current Sheet Trajectory of a Conical Theta Pinch Pulsed Inductive Plasma Accelerator

    Hallock, Ashley K.; Polzin, Kurt A.; Bonds, Kevin W.; Emsellem, Gregory D.


    Results are presented demonstrating the e ect of inductive coil geometry and current sheet trajectory on the exhaust velocity of propellant in conical theta pinch pulsed induc- tive plasma accelerators. The electromagnetic coupling between the inductive coil of the accelerator and a plasma current sheet is simulated, substituting a conical copper frustum for the plasma. The variation of system inductance as a function of plasma position is obtained by displacing the simulated current sheet from the coil while measuring the total inductance of the coil. Four coils of differing geometries were employed, and the total inductance of each coil was measured as a function of the axial displacement of two sep- arate copper frusta both having the same cone angle and length as the coil but with one compressed to a smaller size relative to the coil. The measured relationship between total coil inductance and current sheet position closes a dynamical circuit model that is used to calculate the resulting current sheet velocity for various coil and current sheet con gura- tions. The results of this model, which neglects the pinching contribution to thrust, radial propellant con nement, and plume divergence, indicate that in a conical theta pinch ge- ometry current sheet pinching is detrimental to thruster performance, reducing the kinetic energy of the exhausting propellant by up to 50% (at the upper bound for the parameter range of the study). The decrease in exhaust velocity was larger for coils and simulated current sheets of smaller half cone angles. An upper bound for the pinching contribution to thrust is estimated for typical operating parameters. Measurements of coil inductance for three di erent current sheet pinching conditions are used to estimate the magnetic pressure as a function of current sheet radial compression. The gas-dynamic contribution to axial acceleration is also estimated and shown to not compensate for the decrease in axial electromagnetic acceleration

  14. Superconducting Coil of Po Dipole


    The Po superconducting dipole was built as a prototype beam transport magnet for the SPS extracted proton beam P0. Its main features were: coil aperture 72 mm, length 5 m, room-temperature yoke, NbTi cable conductor impregnated with solder, nominal field 4.2 T at 4.7 K (87% of critical field). It reached its nominal field without any quench.After this successful test up to its nominal field of 4.2 T, the power was not raised to reach a quench. The magnet was not installed in a beam and had no other further use. Nevertheless its construction provided knowledges and experience which became useful in the design and construction of the LHC magnets. The photo shows a detail of the inner layer winding before superposing the outer layer to form the complete coil of a pole. Worth noticing is the interleaved glass-epoxy sheet (white) with grooved channels for the flow of cooling helium. See also 8211532X.

  15. Multicoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone.

    Jason Trigg

    Full Text Available The alpha-helical coiled coil can adopt a variety of topologies, among the most common of which are parallel and antiparallel dimers and trimers. We present Multicoil2, an algorithm that predicts both the location and oligomerization state (two versus three helices of coiled coils in protein sequences. Multicoil2 combines the pairwise correlations of the previous Multicoil method with the flexibility of Hidden Markov Models (HMMs in a Markov Random Field (MRF. The resulting algorithm integrates sequence features, including pairwise interactions, through multinomial logistic regression to devise an optimized scoring function for distinguishing dimer, trimer and non-coiled-coil oligomerization states; this scoring function is used to produce Markov Random Field potentials that incorporate pairwise correlations localized in sequence. Multicoil2 significantly improves both coiled-coil detection and dimer versus trimer state prediction over the original Multicoil algorithm retrained on a newly-constructed database of coiled-coil sequences. The new database, comprised of 2,105 sequences containing 124,088 residues, includes reliable structural annotations based on experimental data in the literature. Notably, the enhanced performance of Multicoil2 is evident when tested in stringent leave-family-out cross-validation on the new database, reflecting expected performance on challenging new prediction targets that have minimal sequence similarity to known coiled-coil families. The Multicoil2 program and training database are available for download from

  16. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain

    Wilbur, Jeremy D., E-mail: [Graduate Program in Biophysics, University of California, San Francisco, California 94143 (United States); Hwang, Peter K. [Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 (United States); Brodsky, Frances M. [The G. W. Hooper Foundation, Departments of Microbiology and Immunology and of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143 (United States); Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 (United States); Fletterick, Robert J. [Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 (United States); Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 (United States); Graduate Program in Biophysics, University of California, San Francisco, California 94143 (United States)


    Variable packing interaction related to the conformational flexibility within the huntingtin-interacting protein 1 coiled coil domain. Huntingtin-interacting protein 1 (HIP1) is an important link between the actin cytoskeleton and clathrin-mediated endocytosis machinery. HIP1 has also been implicated in the pathogenesis of Huntington’s disease. The binding of HIP1 to actin is regulated through an interaction with clathrin light chain. Clathrin light chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding. To understand the mechanism of this conformational regulation, a high-resolution crystal structure of a stable fragment from the HIP1 coiled-coil domain was determined. The flexibility of the HIP1 coiled-coil region was evident from its variation from a previously determined structure of a similar region. A hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility.

  17. Novel Anti-Nicotine Vaccine Using a Trimeric Coiled-Coil Hapten Carrier.

    Keith D Miller

    Full Text Available Tobacco addiction represents one of the largest public health problems in the world and is the leading cause of cancer and heart disease, resulting in millions of deaths a year. Vaccines for smoking cessation have shown considerable promise in preclinical models, although functional antibody responses induced in humans are only modestly effective in preventing nicotine entry into the brain. The challenge in generating serum antibodies with a large nicotine binding capacity is made difficult by the fact that this drug is non-immunogenic and must be conjugated as a hapten to a protein carrier. To circumvent the limitations of traditional carriers like keyhole limpet hemocyanin (KLH, we have synthesized a short trimeric coiled-coil peptide (TCC that creates a series of B and T cell epitopes with uniform stoichiometry and high density. Here we compared the relative activities of a TCC-nic vaccine and two control KLH-nic vaccines using Alum as an adjuvant or GLA-SE, which contains a synthetic TLR4 agonist formulated in a stable oil-in-water emulsion. The results showed that the TCC's high hapten density correlated with a better immune response in mice as measured by anti-nicotine Ab titer, affinity, and specificity, and was responsible for a reduction in anti-carrier immunogenicity. The Ab responses achieved with this synthetic vaccine resulted in a nicotine binding capacity in serum that could prevent >90% of a nicotine dose equivalent to three smoked cigarettes (0.05 mg/kg from reaching the brain.

  18. Statistical coil model of the unfolded state: resolving the reconciliation problem.

    Jha, Abhishek K; Colubri, Andrés; Freed, Karl F; Sosnick, Tobin R


    An unfolded state ensemble is generated by using a self-avoiding statistical coil model that is based on backbone conformational frequencies in a coil library, a subset of the Protein Data Bank. The model reproduces two apparently contradicting behaviors observed in the chemically denatured state for a variety of proteins, random coil scaling of the radius of gyration and the presence of significant amounts of local backbone structure (NMR residual dipolar couplings). The most stretched members of our unfolded ensemble dominate the residual dipolar coupling signal, whereas the uniformity of the sign of the couplings follows from the preponderance of polyproline II and beta conformers in the coil library. Agreement with the NMR data substantially improves when the backbone conformational preferences include correlations arising from the chemical and conformational identity of neighboring residues. Although the unfolded ensembles match the experimental observables, they do not display evidence of native-like topology. By providing an accurate representation of the unfolded state, our statistical coil model can be used to improve thermodynamic and kinetic modeling of protein folding.

  19. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.

    Kinross, Kathryn M; Montgomery, Karen G; Kleinschmidt, Margarete; Waring, Paul; Ivetac, Ivan; Tikoo, Anjali; Saad, Mirette; Hare, Lauren; Roh, Vincent; Mantamadiotis, Theo; Sheppard, Karen E; Ryland, Georgina L; Campbell, Ian G; Gorringe, Kylie L; Christensen, James G; Cullinane, Carleen; Hicks, Rodney J; Pearson, Richard B; Johnstone, Ricky W; McArthur, Grant A; Phillips, Wayne A


    Mutations in the gene encoding the p110α subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in human cancers. To better understand the role of mutant PIK3CA in the initiation or progression of tumorigenesis, we generated mice in which a PIK3CA mutation commonly detected in human cancers (the H1047R mutation) could be conditionally knocked into the endogenous Pik3ca locus. Activation of this mutation in the mouse ovary revealed that alone, Pik3caH1047R induced premalignant hyperplasia of the ovarian surface epithelium but no tumors. Concomitantly, we analyzed several human ovarian cancers and found PIK3CA mutations coexistent with KRAS and/or PTEN mutations, raising the possibility that a secondary defect in a co-regulator of PI3K activity may be required for mutant PIK3CA to promote transformation. Consistent with this notion, we found that Pik3caH1047R mutation plus Pten deletion in the mouse ovary led to the development of ovarian serous adenocarcinomas and granulosa cell tumors. Both mutational events were required for early, robust Akt activation. Pharmacological inhibition of PI3K/mTOR in these mice delayed tumor growth and prolonged survival. These results demonstrate that the Pik3caH1047R mutation with loss of Pten is enough to promote ovarian cell transformation and that we have developed a model system for studying possible therapies.

  20. The Status of the Construction of MICE Step IV

    Snopok, P. [Fermilab; Overton, E. [Sheffield U.


    The International Muon Ionization Cooling Experiment will provide the demononstration ionization cooling. The experiment is being built in a series of Steps. Step IV, which consists of a tracking spectrometer upstream and downstream of an absorber/focus-coil module will be completed in early in 2015. In this configuration, the emittance of the muon beam upstream and downstream of the absorbed will be measured precisely allowing the emittance reduction and the factors that determine the ionization-cooling effect to be studied in detail. Each tracking spectrometer consists of a scintillating-fibre tracker placed within a 4 T field provided by the superconducting spectrometer solenoid. The muon beam is transported to the absorber/focus-coil module: a 22 liter volume of liquid hydrogen placed inside a superconducting focusing coil. The properties of lithium hydride, and possibly other absorber materials, will also be studied. All the components of Step IV have been manufactured and integration of the experiment in the MICE Hall at the Rutherford Appleton Laboratory is underway. The construction and performance of Step IV will be described. A full study of ionization cooling will be carried out with Step V of the experiment which will include a short 201 MHz linac module in which beam transport is achieved with a superconducting “coupling-coil”. The status of the preparation of the components of Step V of the experiment will be described briefly.

  1. 49 CFR 236.730 - Coil, receiver.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Coil, receiver. 236.730 Section 236.730 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Coil, receiver. Concentric layers of insulated wire wound around the core of a receiver of an...

  2. Operator coil monitoring Acceptance Test Procedure

    Erhart, M.F.


    The readiness of the Data Acquisition and Control System (DACS) to provide monitoring and control of the Programmable Logic Controller (PLC) abort coils from the Master and RSS stations will be systematically tested during performance of this procedure. It should be noted that these are not physical abort coils but software coils controlled by the software`s ladder logic. The readiness of the DACS to properly interface with the ENRAF wire level gauge installed in the SY-101 storage tank will also be tested. During this test, a verification of all abort coil indications will be conducted at the DACS Development Facility in the 306E Building by injecting an input signal for each DACS sensor that has an associated abort coil until the abort coil actuates, and then ensuring that the status of the abort coil indicated at the Master and RSS stations is correct. Each abort coil will also be tested to ensure that the ``ENABLE`` and ``DISABLE`` controls from the Master and RSS stations function correctly, and only with the use of proper passwords.

  3. Evidence-based pathology: umbilical cord coiling.

    Khong, T Y


    The generation of a pathology test result must be based on criteria that are proven to be acceptably reproducible and clinically relevant to be evidence-based. This review de-constructs the umbilical cord coiling index to illustrate how it can stray from being evidence-based. Publications related to umbilical cord coiling were retrieved and analysed with regard to how the umbilical coiling index was calculated, abnormal coiling was defined and reference ranges were constructed. Errors and other influences that can occur with the measurement of the length of the umbilical cord or of the number of coils can compromise the generation of the coiling index. Definitions of abnormal coiling are not consistent in the literature. Reference ranges defining hypocoiling or hypercoiling have not taken those potential errors or the possible effect of gestational age into account. Even the way numerical test results in anatomical pathology are generated, as illustrated by the umbilical coiling index, warrants a critical analysis into its evidence base to ensure that they are reproducible or free from errors.

  4. Coil Optimization for High Temperature Superconductor Machines

    Mijatovic, Nenad; Jensen, Bogi Bech; Abrahamsen, Asger Bech


    This paper presents topology optimization of HTS racetrack coils for large HTS synchronous machines. The topology optimization is used to acquire optimal coil designs for the excitation system of 3 T HTS machines. Several tapes are evaluated and the optimization results are discussed. The optimiz...

  5. Functional investigation of the plant-specific long coiled-coil proteins PAMP-INDUCED COILED-COIL (PICC and PICC-LIKE (PICL in Arabidopsis thaliana.

    Sowmya Venkatakrishnan

    Full Text Available We have identified and characterized two Arabidopsis long coiled-coil proteins PAMP-INDUCED COILED-COIL (PICC and PICC-LIKE (PICL. PICC (147 kDa and PICL (87 kDa are paralogs that consist predominantly of a long coiled-coil domain (expanded in PICC, with a predicted transmembrane domain at the immediate C-terminus. Orthologs of PICC and PICL were found exclusively in vascular plants. PICC and PICL GFP fusion proteins are anchored to the cytoplasmic surface of the endoplasmic reticulum (ER membrane by a C-terminal transmembrane domain and a short tail domain, via a tail-anchoring mechanism. T-DNA-insertion mutants of PICC and PICL as well as the double mutant show an increased sensitivity to the plant abiotic stress hormone abscisic acid (ABA in a post-germination growth response. PICC, but not PICL gene expression is induced by the bacterial pathogen-associated molecular pattern (PAMP flg22. T-DNA insertion alleles of PICC, but not PICL, show increased susceptibility to the non-virulent strain P. syringae pv. tomato DC3000 hrcC, but not to the virulent strain P. syringae pv. tomato DC3000. This suggests that PICC mutants are compromised in PAMP-triggered immunity (PTI. The data presented here provide first evidence for the involvement of a plant long coiled-coil protein in a plant defense response.

  6. Magnetic Fields at the Center of Coils

    Binder, Philippe; Hui, Kaleonui; Goldman, Jesse


    In this note we synthesize and extend expressions for the magnetic field at the center of very short and very long current-carrying coils. Elementary physics textbooks present the following equation for the magnetic field inside a very long current-carrying coil (solenoid): B[subscript sol] = µ[subscript 0] (N/L) I, (1) where I is the current, N…

  7. Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice.

    Cooper, Ayelet; Grigoryan, Gayane; Guy-David, Liora; Tsoory, Michael M; Chen, Alon; Reuveny, Eitan


    G protein-activated inwardly rectifying K+ channels (GIRK) generate slow inhibitory postsynaptic potentials in the brain via G(i/o) protein-coupled receptors. GIRK2, a GIRK subunit, is widely abundant in the brain and has been implicated in various functions and pathologies, such as learning and memory, reward, motor coordination, and Down syndrome. Down syndrome, the most prevalent cause of mental retardation, results from the presence of an extra maternal chromosome 21 (trisomy 21), which comprises the Kcnj6 gene (GIRK2). The present study examined the behaviors and cellular physiology properties in mice harboring a single trisomy of the Kcnj6 gene. Kcnj6 triploid mice exhibit deficits in hippocampal-dependent learning and memory, altered responses to rewards, hampered depotentiation, a form of excitatory synaptic plasticity, and have accentuated long-term synaptic depression. Collectively the findings suggest that triplication of Kcnj6 gene may play an active role in some of the abnormal neurological phenotypes found in Down syndrome.

  8. Analysing radio-frequency coil arrays in high-field magnetic resonance imaging by the combined field integral equation method.

    Wang, Shumin; Duyn, Jeff H


    We present the combined field integral equation (CFIE) method for analysing radio-frequency coil arrays in high-field magnetic resonance imaging (MRI). Three-dimensional models of coils and the human body were used to take into account the electromagnetic coupling. In the method of moments formulation, we applied triangular patches and the Rao-Wilton-Glisson basis functions to model arbitrarily shaped geometries. We first examined a rectangular loop coil to verify the CFIE method and also demonstrate its efficiency and accuracy. We then studied several eight-channel receive-only head coil arrays for 7.0 T SENSE functional MRI. Numerical results show that the signal dropout and the average SNR are two major concerns in SENSE coil array design. A good design should be a balance of these two factors.

  9. Analysis of mechanical characteristics of superconducting field coil for 17 MW class high temperature superconducting synchronous motor

    Kim, J. H.; Park, S. I.; Im, S. H.; Kim, H. M. [Jeju National University, Jeju (Korea, Republic of)


    Superconducting field coils using a high-temperature superconducting (HTS) wires with high current density generate high magnetic field of 2 to 5 [T] and electromagnetic force (Lorentz force) acting on the superconducting field coils also become a very strong from the point of view of a mechanical characteristics. Because mechanical stress caused by these powerful electromagnetic force is one of the factors which worsens the critical current performance and structural characteristics of HTS wire, the mechanical stress analysis should be performed when designing the superconducting field coils. In this paper, as part of structural design of superconducting field coils for 17 MW class superconducting ship propulsion motor, mechanical stress acting on the superconducting field coils was analyzed and structural safety was also determined by the coupling analysis system that is consists of commercial electromagnetic field analysis program and structural analysis program.

  10. NMR local coil with adjustable spacing

    Dembinski, G.T.


    A local coil assembly for use in NMR imaging is described which comprises: a base; a first local coil module mounted to the base and extending upward therefrom; sockets disposed in the base, each at a different distance from the first local coil module; a second local coil module having a connector therein which mates with each of the sockets to enable the second local coil module to be connected to the base at any one of the sockets; and a set of reactive components. The values of the respective reactive components are selected such that the second local oil module may be connected to any of the sockets without any substantial change in the resonant frequency of the assembly.

  11. A study on geometry effect of transmission coil for micro size magnetic induction coil

    Lee, Kyung Hwa; Jun, Byoung Ok; Kim, Seunguk; Lee, Gwang Jun; Ryu, Mingyu; Choi, Ji-Woong; Jang, Jae Eun


    The effects of transmission (Tx) coil structure have been studied for micro-size magnetic induction coil. The size of the receiving (Rx) coil should be shrunk to the micrometer level for the various new applications such as micro-robot and wireless body implanted devices. In case of the macro-scale magnetic induction coil, the power transmission efficiency is generally considered to be higher as the inductance of the transmission coil became larger; however, the large size difference between macro-size Tx coil and micro-size Rx coil can decrease the power transmission efficiency due to the difference of resonance frequency. Here, we study a correlation of the power transmission with the size and distance between the macro-size Tx and micro-size Rx coils using magnetic induction technique. The maximum power efficiency was 0.28/0.23/0.13/0.12% at the distance of 0.3/1/3/5 cm between Rx and Tx coil. In addition, more efficient wireless power transferring method is suggested with a floating coil for the body implantable devices. The voltage output increased up to 5.4 mV than the original one Tx coil system. The results demonstrated the foundational wireless power transferring system with enhanced power efficiency.

  12. Detection of alpha-helical coiled-coil dimer formation by spin-labeled synthetic peptides: a model parallel coiled-coil peptide and the antiparallel coiled coil formed by a replica of the ProP C-terminus.

    Hillar, Alexander; Tripet, Brian; Zoetewey, David; Wood, Janet M; Hodges, Robert S; Boggs, Joan M


    Electron paramagnetic resonance spectroscopy was used to determine relative peptide orientation within homodimeric, alpha-helical coiled-coil structures. Introduction of cysteine (Cys) residues into peptides/proteins for spin labeling allows detection of their oligomerization from exchange broadening or dipolar interactions between residues within 25 A of each other. Two synthetic peptides containing Cys substitutions were used: a 35-residue model peptide and the 30-residue ProP peptide. The model peptide is known to form a stable, parallel homodimeric coiled coil, which is partially destabilized by Cys substitutions at heptad a and d positions (peptides C30a and C33d). The ProP peptide, a 30-residue synthetic peptide, corresponds to residues 468-497 of osmoregulatory transporter ProP from Escherichia coli. It forms a relatively unstable, homodimeric coiled coil that is predicted to be antiparallel in orientation. Cys was introduced in heptad g positions of the ProP peptide, near the N-terminus (K473C, creating peptide C473g) or closer to the center of the sequence (E480C, creating peptide C480g). In contrast to the destabilizing effect of Cys substitution at the core heptad a or d positions of model peptides C30a and C33d, circular dichroism spectroscopy showed that Cys substitutions at the heptad g positions of the ProP peptide had little or no effect on coiled-coil stability. Thermal denaturation analysis showed that spin labeling increased the stability of the coiled coil for all peptides. Strong exchange broadening was detected for both C30a and C33d, in agreement with a parallel structure. EPR spectra of C480g had a large hyperfine splitting of about 90 G, indicative of strong dipole-dipole interactions and a distance between spin-labeled residues of less than 9 A. Spin-spin interactions were much weaker for C473g. These results supported the hypothesis that the ProP peptide primarily formed an antiparallel coiled coil, since formation of a parallel dimer

  13. Simulated Stellarator Edge Behavior with Modified HSX Coils

    Bader, A.; Stephey, L. A.; Anderson, D. T.; Feng, Y.; Hegna, C. C.; Schmitz, O.; Talmadge, J. N.


    Predicting the edge behavior of a 3D device is a difficult but necessary requirement in the design of new fusion devices. In this poster we focus on prototypical stellarators generated through modifications to the HSX coils. We employ both helical coils to change the island size without altering the rotational transform, and divertor dipole coils to alter the internal structure of the islands. To determine the edge behavior of the designs we use simple metrics obtained through vacuum field-line following along with advanced simulation capabilities from the coupled codes EMC3-EIRENE. We show that strike point locations and concentrations can be altered with substantial changes to edge island sizes. Changes to the internal structure of the islands, producing alterations to flow structures and plasma density, but do not have a significant impact on strike point calculations or predicted heat flux. Results have implications on the role of islands in edges of stellarators and other 3D devices. Work supported by DOE-SC0006103.

  14. Promoted-Combustion Chamber with Induction Heating Coil

    Richardson, Erin; Hagood, Richard; Lowery, Freida; Herald, Stephen


    prevent heating of the base of the chamber during use. A sapphire cylinder protects the coil against slag generated during an experiment. The induction coil is energized by a 6-kW water-cooled power supply operating at a frequency of 400 kHz. The induction coil is part of a parallel-tuned circuit, the tuning of which is used to adjust the coupling of power to the specimen. The chamber is mounted on a test stand along with pumps, valves, and plumbing for transferring pressurized gas into and out of the chamber. In addition to multiple video cameras aimed through the windows encircling the chamber, the chamber is instrumented with gauges for monitoring the progress of an experiment. One of the gauges is a dual-frequency infrared temperature transducer aimed at the specimen through one window. Chamber operation is achieved via a console that contains a computer running apparatus-specific software, a video recorder, and real-time video monitors. For safety, a blast wall separates the console from the test stand.

  15. An ultrasensitive electrochemiluminescence sensor based on reduced graphene oxide-copper sulfide composite coupled with capillary electrophoresis for determination of amlodipine besylate in mice plasma.

    Wei, Yanfen; Wang, Hao; Sun, Shuangjiao; Tang, Lifu; Cao, Yupin; Deng, Biyang


    A new electrochemiluminescence (ECL) sensor based on reduced graphene oxide-copper sulfide (rGO-CuS) composite coupled with capillary electrophoresis (CE) was constructed for the ultrasensitive detection of amlodipine besylate (AML) for the first time. In this work, rGO-CuS composite was synthesized by one-pot hydrothermal method and used for electrode modification. The electrochemical and ECL behaviors of the sensor were investigated. More than 5-fold enhance in ECL intensity was observed after modified with rGO-CuS composite. The results can be ascribed to the presence of rGO-CuS composite on the electrode surface that facilitates the electron transfer rate between the electroactive center of Ru(bpy)3(2+) and the electrode. The ECL sensor was coupled with CE to improve the selectivity and the CE-ECL parameters that affect separation and detection were optimized. Under the optimum conditions, the linear ranges for AML was 0.008-5.0μg/mL with a detection limit of 2.8ng/mL (S/N=3). The method displayed the advantages of high sensitivity, good selectivity, wide linear range, low detection limit and fine reproducibility, and was used to analyze AML in mice plasma with a satisfactory result, which holds a great potential in the field of pharmaceutical analysis.

  16. Simultaneous formation of right- and left-handed anti-parallel coiled-coil interfaces by a coil2 fragment of human lamin A.

    Kapinos, Larisa E; Burkhard, Peter; Herrmann, Harald; Aebi, Ueli; Strelkov, Sergei V


    The elementary building block of all intermediate filaments (IFs) is a dimer featuring a central α-helical rod domain flanked by the N- and C-terminal end domains. In nuclear IF proteins (lamins), the rod domain consists of two coiled-coil segments, coil1 and coil2, that are connected by a short non-helical linker. Coil1 and the C-terminal part of coil2 contain the two highly conserved IF consensus motifs involved in the longitudinal assembly of dimers. The previously solved crystal structure of a lamin A fragment (residues 305-387) corresponding to the second half of coil2 has yielded a parallel left-handed coiled coil. Here, we present the crystal structure and solution properties of another human lamin A fragment (residues 328-398), which is largely overlapping with fragment 305-387 but harbors a short segment of the tail domain. Unexpectedly, no parallel coiled coil forms within the crystal. Instead, the α-helices are arranged such that two anti-parallel coiled-coil interfaces are formed. The most significant interface has a right-handed geometry, which is accounted for by a characteristic 15-residue repeat pattern that overlays with the canonical heptad repeat pattern. The second interface is a left-handed anti-parallel coiled coil based on the predicted heptad repeat pattern. In solution, the fragment reveals only a weak dimerization propensity. We speculate that the C-terminus of coil2 might unzip, thereby allowing for a right-handed coiled-coil interface to form between two laterally aligned dimers. Such an interface might co-exist with a heterotetrameric left-handed coiled-coil assembly, which is expected to be responsible for the longitudinal A(CN) contact.

  17. N@a and N@d: Oligomer and Partner Specification by Asparagine in Coiled-Coil Interfaces.

    Fletcher, Jordan M; Bartlett, Gail J; Boyle, Aimee L; Danon, Jonathan J; Rush, Laura E; Lupas, Andrei N; Woolfson, Derek N


    The α-helical coiled coil is one of the best-studied protein-protein interaction motifs. As a result, sequence-to-structure relationships are available for the prediction of natural coiled-coil sequences and the de novo design of new ones. However, coiled coils adopt a wide range of oligomeric states and topologies, and our understanding of the specification of these and the discrimination between them remains incomplete. Gaps in our knowledge assume more importance as coiled coils are used increasingly to construct biomimetic systems of higher complexity; for this, coiled-coil components need to be robust, orthogonal, and transferable between contexts. Here, we explore how the polar side chain asparagine (Asn, N) is tolerated within otherwise hydrophobic helix-helix interfaces of coiled coils. The long-held view is that Asn placed at certain sites of the coiled-coil sequence repeat selects one oligomer state over others, which is rationalized by the ability of the side chain to make hydrogen bonds, or interactions with chelated ions within the coiled-coil interior of the favored state. We test this with experiments on de novo peptide sequences traditionally considered as directing parallel dimers and trimers, and more widely through bioinformatics analysis of natural coiled-coil sequences and structures. We find that when located centrally, rather than near the termini of such coiled-coil sequences, Asn does exert the anticipated oligomer-specifying influence. However, outside of these bounds, Asn is observed less frequently in the natural sequences, and the synthetic peptides are hyperthermostable and lose oligomer-state specificity. These findings highlight that not all regions of coiled-coil repeat sequences are equivalent, and that care is needed when designing coiled-coil interfaces.

  18. Analysis of transmission efficiency of the superconducting resonance coil according the materials of cooling system

    Lee, Yu Kyeong; Hwang, Jun Won; Choi, Hyo Sang [Chosun University, Gwangju (Korea, Republic of)


    The wireless power transfer (WPT) system using a magnetic resonance was based on magnetic resonance coupling of the transmission and the receiver coils. In these system, it is important to maintain a high quality-factor (Q-factor) to increase the transmission efficiency of WPT system. Our research team used a superconducting coil to increase the Q-factor of the magnetic resonance coil in WPT system. When the superconductor is applied in these system, we confirmed that transmission efficiency of WPT system was higher than normal conductor coil through a preceding study. The efficiency of the transmission and the receiver coil is affected by the magnetic shielding effect of materials around the coils. The magnetic shielding effect is dependent on the type, thickness, frequency, distance, shape of materials. Therefore, it is necessary to study the WPT system on the basis of these conditions. In this paper, the magnetic shield properties of the cooling system were analyzed using the High-Frequency Structure Simulation (HFSS, Ansys) program. We have used the shielding materials such as plastic, aluminum and iron, etc. As a result, when we applied the fiber reinforced polymer (FRP), the transmission efficiency of WPT was not affected because electromagnetic waves went through the FRP. On the other hand, in case of a iron and aluminum, transmission efficiency was decreased because of their electromagnetic shielding effect. Based on these results, the research to improve the transmission efficiency and reliability of WPT system is continuously necessary.

  19. Enhancement of humoral immunity in mice by coupling pUCpGs10 and aluminium to the HCV recombinant immunogen

    Zhan Na


    Full Text Available Abstract Aim To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides and aluminium adjuvants are complexed with the HCV (Hepatitis C virus recombinant immunogen in mice. Methods After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10 and/or aluminium(antigen+CpG+alum, antigen+CpG, antigen+alum, antigen+PBS, enzyme-linked immunosorbent assay (ELISA was used to measure the specific serum antibody titers of IgG, to determine the neutralization response to various peptide genotypes, and to determine the concentration of IL-6 and IL-10 in supernatants of in vitro cultured splenic lymphocytes. Enzyme-linked immunospot assay (ELISPOT was used to quantify the non-specific and specific splenic antibody-secreting cells (ASCs, and flow cytometry (FCM determined the ratio of different splenic lymphocytes. The serum of rabbits immunized with the recombinant pBVGST/HVR1 antigen immunoprecipitated the HCV isolated from 12 patients' serum. Results The sera antibody titers were 1:51200, 1:9051, 1:18102, 1:6400 respectively after the final immunization and demonstrated good neutralization responses to the six gene peptide containing 1a, 1b, 2a, 3a, 4a and 6a. The aluminum adjuvant increased the population of both specific ASCs (P +CD27+ (P +CD38+ splenic lymphocytes with the aluminum and pUCpGs10 adjuvant present compared to the control group(P Conclusions 1. The aluminum adjuvant induces a potent Th2-biased immune response by increasing both the populations of specific and total ASCs and the ratio of CD19+CD27+ cells. 2. The pUCpGs10 complexed with the aluminum adjuvant boosts the population of plasma cells and increase the efficiency of the immune response. 3. The two adjuvants have synergistic effects on humoral immunity. 4. The recombinant HVR1 protein has the possibility of generating broadly reactive anti-HVR1 antibody.

  20. Switching transients in a superconducting coil

    Owen, E.W.; Shimer, D.W.


    A study is made of the transients caused by the fast dump of large superconducting coils. Theoretical analysis, computer simulation, and actual measurements are used. Theoretical analysis can only be applied to the simplest of models. In the computer simulations two models are used, one in which the coil is divided into ten segments and another in which a single coil is employed. The circuit breaker that interrupts the current to the power supply, causing a fast dump, is represented by a time and current dependent conductance. Actual measurements are limited to measurements made incidental to performance tests on the MFTF Yin-yang coils. It is found that the breaker opening time is the critical factor in determining the size and shape of the transient. Instantaneous opening of the breaker causes a lightly damped transient with large amplitude voltages to ground. Increasing the opening time causes the transient to become a monopulse of decreasing amplitude. The voltages at the external terminals are determined by the parameters of the external circuit. For fast opening times the frequency depends on the dump resistor inductance, the circuit capacitance, and the amplitude on the coil current. For slower openings the dump resistor inductance and the current determine the amplitude of the voltage to ground at the terminals. Voltages to ground are less in the interior of the coil, where transients related to the parameters of the coil itself are observed.

  1. Crystal structure of a coiled-coil domain from human ROCK I.

    Daqi Tu

    Full Text Available The small GTPase Rho and one of its targets, Rho-associated kinase (ROCK, participate in a variety of actin-based cellular processes including smooth muscle contraction, cell migration, and stress fiber formation. The ROCK protein consists of an N-terminal kinase domain, a central coiled-coil domain containing a Rho binding site, and a C-terminal pleckstrin homology domain. Here we present the crystal structure of a large section of the central coiled-coil domain of human ROCK I (amino acids 535-700. The structure forms a parallel α-helical coiled-coil dimer that is structurally similar to tropomyosin, an actin filament binding protein. There is an unusual discontinuity in the coiled-coil; three charged residues (E613, R617 and D620 are positioned at what is normally the hydrophobic core of coiled-coil packing. We speculate that this conserved irregularity could function as a hinge that allows ROCK to adopt its autoinhibited conformation.

  2. Crystal Structure of the Central Coiled-Coil Domain from Human Liprin-[beta]2

    Stafford, Ryan L.; Tang, Ming-Yun; Sawaya, Michael R.; Phillips, Martin L.; Bowie, James U. (UCLA)


    Liprins are a conserved family of scaffolding proteins important for the proper regulation and development of neuronal synapses. Humans have four liprin-{alpha}s and two liprin-{beta}s which all contain long coiled-coil domains followed by three tandem SAM domains. Complex interactions between the coiled-coil and SAM domains are thought to create liprin scaffolds, but the structural and biochemical properties of these domains remain largely uncharacterized. In this study we find that the human liprin-{beta}2 coiled-coil forms an extended dimer. Several protease-resistant subdomains within the liprin-{beta}1 and liprin-{beta}2 coiled-coils were also identified. A 2.0 {angstrom} crystal structure of the central, protease-resistant core of the liprin-{beta}2 coiled-coil reveals a parallel helix orientation. These studies represent an initial step toward determining the overall architecture of liprin scaffolds and understanding the molecular basis for their synaptic functions.

  3. Coil migration after endovascular coil occlusion of internal carotid artery pseudoaneurysms within the sphenoid sinus.

    Struffert, T; Buhk, J H; Buchfelder, M; Rohde, V; Doerfler, A; Knauth, M


    We report two cases of coil migration after endovascular treatment of pseudoaneurysm of the internal carotid artery within the sphenoid sinus with coils and noncovered stents. Two patients underwent sphenoid sinus exposure for pituitary adenoma and chronic infection, respectively. As a complication pseudoaneurysms of the internal carotid artery within the sphenoid sinus developed. One patient was treated with stent and coils, the second with coils alone. Both patients experienced coil migration after 9 and 26 months, respectively, with the necessity for further treatment. Imaging was performed using flat detector computed tomography (FD-CT). Literature review revealed two additional cases of coil migration and four patients with the same treatment in stable condition. Pseudoaneurysms of the internal carotid artery are a special entity and the environment of the aneurysm within the sphenoid sinus may change over a long time. Coil embolization may lead to the late onset complication of coil migration with the possible risk of acute epistaxis. As a consequence, these patients need a careful and prolonged follow up. FD-CT is an appropriate technique to visualize the implanted coils and if present the migration of coil material.

  4. Plasma response based RMP coil geometry optimization for an ITER plasma

    Zhou, Lina; Liu, Yueqiang; Liu, Yue; Yang, Xu


    Based on an ITER 15MA Q  =  10 inductive scenario, a systematic numerical investigation is carried out in order to understand the effect of varying the geometry of the magnetic coils, used for controlling the edge localized modes in tokamaks, on the plasma response to the resonant magnetic perturbation (RMP) fields produced by these coils. Toroidal computations show that both of the plasma response based figures of merit—one is the pitch resonant radial field component near the plasma edge and the other is the plasma displacement near the X-point of the separatrix—consistently yield the same prediction for the optimal coil geometry. With a couple of exceptions, the presently designed poloidal location of the ITER upper and lower rows of RMP coils is close to the optimum, according to the plasma response based criteria. This holds for different coil current configurations with n  =  2, 3, 4, as well as different coil phasing between the upper and lower rows. The coils poloidal width from the present design, on the other hand, is sub-optimal for the upper and lower rows. Modelling also finds that the plasma response amplitude sharply decreases by moving the middle row RMP coils of ITER from the designed radial location (just inside the inner vacuum vessel) outwards (outside the outer vacuum vessel). The decay rate is sensitively affected by the middle row coils’ poloidal coverage for low-n (n  =  1, 2) RMP fields, but not for high-n (n  =  4) fields.

  5. About the analisys of simultaneous induction hardening method of pinions with circular coil

    Gabriel Cheregi


    Full Text Available This paper proposes simultaneous hardeningmethod of pinions with eddy currents using circular coil.This proceeding remark in little clear advantage facefrom individual treatment of pinions tooth. The heatinganalysis of treat piece needs solution of thermal diffusionproblems coupled with eddy currents problem. Thereforethe experiments number in designing process can bedecreased and a better knowledge of the process can beobtained.

  6. Superconducting coil development and motor demonstration: Overview

    Gubser, D. U.


    Superconducting bismuth-cuprate wires, coils, and magnets are being produced by industry as part of a program to test the viability of using such magnets in Naval systems. Tests of prototype magnets, coils, and wires reveal progress in commercially produced products. The larger magnets will be installed in an existing superconducting homopolar motor and operated initially at 4.2K to test the performance. It is anticipated that approximately 400 Hp will be achieved by the motor. This article reports on the initial tests of the magnets, coils, and wires as well as the development program to improve their performance.

  7. Magnetic field mapper based on rotating coils

    AUTHOR|(CDS)2087244; Arpaia, Pasquale

    This thesis presents a magnetic field mapper based on rotating coils. The requirements, the architecture, the conceptual design, and the prototype for straight magnets were shown. The proposed system is made up of a rotating coil transducer and a train-like system for longitudinal motion and positioning inside magnet bore. The mapper allows a localized measurement of magnetic fields and the variation of the harmonic multipole content in the magnet ends. The proof-of-principle demonstration and the experimental characterization of the rotating-coil transducer specifically conceived for mapping validated the main objective of satisfying the magnetic measurement needs of the next generation of compact accelerators.

  8. Magnetically Coupled Magnet-Spring Oscillators

    Donoso, G.; Ladera, C. L.; Martin, P.


    A system of two magnets hung from two vertical springs and oscillating in the hollows of a pair of coils connected in series is a new, interesting and useful example of coupled oscillators. The electromagnetically coupled oscillations of these oscillators are experimentally and theoretically studied. Its coupling is electromagnetic instead of…

  9. Improved signal-to-noise ratio performance in magnetic resonance imaging by using a multilayered surface coil array--a simulation study.

    Liang, Dandan; Hui, Hon Tat; Yeo, Tat Soon


    A multilayered surface coil array for magnetic resonance imaging with an improved signal-to-noise ratio (SNR) performance is introduced and investigated by a simulation study. By using an effective decoupling method, the strong mutual coupling effect between the coil layers can be accurately removed, leading to a coherent combination of the signals of the individual coils. This results in a much stronger received signal power which increases with the number of coil layers in the array. This, together with a smaller rate of increase of noise power with the number of coil layers, leads to a net increase in the SNR of array output with the number of coil layers in the array. Rigorous numerical simulation examples have been carried out to confirm and verify the performance of the new array.

  10. Characterization of Coupled Coil in Seawater for Wireless Power Transfer


    Mechatronics and Autionation Changchun China, vol. 26, no. 4, pp. 526–538 (October). [2] Q. Gau, X. Wu, J. Liu, and Z. Yang. 2009. “Modeling and...Simulation of Contact-less Power Transformers for Underwater Applications,” IEEE Proceedings International Conference on Mechatronics and Autionation

  11. Helical coil thermal hydraulic model

    Caramello, M.; Bertani, C.; De Salve, M.; Panella, B.


    A model has been developed in Matlab environment for the thermal hydraulic analysis of helical coil and shell steam generators. The model considers the internal flow inside one helix and its associated control volume of water on the external side, both characterized by their inlet thermodynamic conditions and the characteristic geometry data. The model evaluates the behaviour of the thermal-hydraulic parameters of the two fluids, such as temperature, pressure, heat transfer coefficients, flow quality, void fraction and heat flux. The evaluation of the heat transfer coefficients as well as the pressure drops has been performed by means of the most validated literature correlations. The model has been applied to one of the steam generators of the IRIS modular reactor and a comparison has been performed with the RELAP5/Mod.3.3 code applied to an inclined straight pipe that has the same length and the same elevation change between inlet and outlet of the real helix. The predictions of the developed model and RELAP5/Mod.3.3 code are in fairly good agreement before the dryout region, while the dryout front inside the helical pipes is predicted at a lower distance from inlet by the model.

  12. Coil measurement data acquisition and curing press control system for SSC dipole magnet coils

    Dickey, C.E.


    A coil matching program, similar in theory to the methods used to match Tevatron coils, is being developed at Fermilab. Modulus of elasticity and absolute coil size will be determined at 18-inch intervals along the coils while in the coil curing press immediately following the curing process. A data acquisition system is under construction to automatically acquire and manage the large quantities of data that result. Data files will be transferred to Fermilab's VAX Cluster for long-term storage and actual coil matching. The data acquisition system will also provide the control algorithm for the curing press hydraulic system. A description of the SSC Curing Press Data Acquisition and Controls System will be reported. 20 figs.

  13. Coil geometry effects on scanning single-coil magnetic induction tomography

    Feldkamp, Joe R.; Quirk, Stephen


    Alternative coil designs for single coil magnetic induction tomography are considered in this work, with the intention of improving upon the standard design used previously. In particular, we note that the blind spot associated with this coil type, a portion of space along its axis where eddy current generation can be very weak, has an important effect on performance. The seven designs tested here vary considerably in the size of their blind spot. To provide the most discerning test possible, we use laboratory phantoms containing feature dimensions similar to blind spot size. Furthermore, conductivity contrasts are set higher than what would occur naturally in biological systems, which has the effect of weakening eddy current generation at coil locations that straddle the border between high and low conductivity features. Image reconstruction results for the various coils show that coils with smaller blind spots give markedly better performance, though improvements in signal-to-noise ratio could alter that conclusion.

  14. Magnetic propulsion of a magnetic device using three square-Helmholtz coils and a square-Maxwell coil.

    Ha, Yong H; Han, Byung H; Lee, Soo Y


    We introduce a square coil system for remote magnetic navigation of a magnetic device without any physical movements of the coils. We used three square-Helmholtz coils and a square-Maxwell coil for magnetic propulsion of a small magnet along the desired path. All the square coils are mountable on a cubic frame that has an opening to accommodate a living subject. The square-Helmholtz coils control the magnetic propulsion direction by generating uniform magnetic field along the desired direction while the square-Maxwell coil controls the propulsion force by generating magnetic gradient field. We performed magnetic propulsion experiments with a down-scaled coil set and a three-channel coil driver. Experimental results demonstrate that we can use the square coil set for magnetic navigation of a magnetic device without any physical movements of the coils.

  15. Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.

    Barfoot, Tasida; Herdendorf, Timothy J; Behning, Bryanna R; Stohr, Bradley A; Gao, Yang; Kreuzer, Kenneth N; Nelson, Scott W


    Rad50 and Mre11 form a complex involved in the detection and processing of DNA double strand breaks. Rad50 contains an anti-parallel coiled-coil with two absolutely conserved cysteine residues at its apex. These cysteine residues serve as a dimerization domain and bind a Zn(2+) cation in a tetrathiolate coordination complex known as the zinc-hook. Mutation of the zinc-hook in bacteriophage T4 is lethal, indicating the ability to bind Zn(2+) is critical for the functioning of the MR complex. In vitro, we found that complex formation between Rad50 and a peptide corresponding to the C-terminal domain of Mre11 enhances the ATPase activity of Rad50, supporting the hypothesis that the coiled-coil is a major conduit for communication between Mre11 and Rad50. We constructed mutations to perturb this domain in the bacteriophage T4 Rad50 homolog. Deletion of the Rad50 coiled-coil and zinc-hook eliminates Mre11 binding and ATPase activation but does not affect its basal activity. Mutation of the zinc-hook or disruption of the coiled-coil does not affect Mre11 or DNA binding, but their activation of Rad50 ATPase activity is abolished. Although these mutants excise a single nucleotide at a normal rate, they lack processivity and have reduced repetitive exonuclease rates. Restricting the mobility of the coiled-coil eliminates ATPase activation and repetitive exonuclease activity, but the ability to support single nucleotide excision is retained. These results suggest that the coiled-coiled domain adopts at least two conformations throughout the ATPase/nuclease cycle, with one conformation supporting enhanced ATPase activity and processivity and the other supporting nucleotide excision.

  16. A Calibrating Device for Rogowski Coil Development

    LV Liang; LI Junhao; HUANG Jianjun; JI Shengchang; LI Yanming


    A calibrating device for the Rogowski coil is developed,which can be used to calibrate the Rogowski coil having a partial response time within tens of nanoseconds.Its key component is a step current generator,which can generate the output with a rise time of less than 2 ns and a duration of larger than 300 ns.The step current generator is composed by a pulse forming line(PFL)and a pulse transmission line(PTL).A TEM(transverse electromagnetic mode)coaxial measurement unit is used as PTL,and the coil to be calibrated and the referenced standard Rogowski coil can be fixed in the unit.The effect of the dimensions of the TEM unit is discussed theoretically as well as experimentally.

  17. Screen-printed flexible MRI receive coils.

    Corea, Joseph R; Flynn, Anita M; Lechêne, Balthazar; Scott, Greig; Reed, Galen D; Shin, Peter J; Lustig, Michael; Arias, Ana C


    Magnetic resonance imaging is an inherently signal-to-noise-starved technique that limits the spatial resolution, diagnostic image quality and results in typically long acquisition times that are prone to motion artefacts. This limitation is exacerbated when receive coils have poor fit due to lack of flexibility or need for padding for patient comfort. Here, we report a new approach that uses printing for fabricating receive coils. Our approach enables highly flexible, extremely lightweight conforming devices. We show that these devices exhibit similar to higher signal-to-noise ratio than conventional ones, in clinical scenarios when coils could be displaced more than 18 mm away from the body. In addition, we provide detailed material properties and components performance analysis. Prototype arrays are incorporated within infant blankets for in vivo studies. This work presents the first fully functional, printed coils for 1.5- and 3-T clinical scanners.

  18. Coiling Temperature Control in Hot Strip Mill

    Imanari, Hiroyuki; Fujiyama, Hiroaki

    Coiling temperature is one of the most significant factors in products of hot strip mill to determine material properties such as strength, toughness of steel, so it is very important to achieve accurate coiling temperature control (CTC). Usually there are a few pyrometers on the run out table in hot strip mill, therefore temperature model and its adapting system have large influences on the accuracy of CTC. Also unscheduled change of rolling speed has a bad effect to keep coiling temperature as its target. Newly developed CTC system is able to get very accurate coiling temperature against uncertain factors and disturbances by adopting easily identified temperature model, learning method and dynamic set up function. The features of the CTC system are discussed with actual data, and the effectiveness of the system is shown by actual control results.

  19. MR angiography after coiling of intracranial aneurysms

    Schaafsma, J.D.


    Introduction Endovascular occlusion with detachable coils has become an alternative treatment to neurosurgical clipping of intracranial aneurysms over the last two decades. Its minimal invasiveness is the most important advantage of this treatment compared to clipping. The disadvantage of occlusion

  20. Mechanical resonances of helically coiled carbon nanowires

    Saini, D; Behlow, H; Podila, R; Dickel, D; Pillai, B; Skove, M J; Serkiz, S M; Rao, A M


    ...) mainly due to their geometrical complexity. The advent of helically coiled micro/nanoscale structures in nano-robotics, nano-inductors, and impact protection coatings has necessitated the development of new methodologies for determining...

  1. The Magnetic Field of Helmholtz Coils

    Berridge, H. J. J.


    Describes the magnetic field of Helmholtz coils qualitatively and then provides the basis for a quantitative expression. Since the mathematical calculations are very involved, a computer program for solving the mathematical expression is presented and explained. (GS)

  2. Ramping turn-to-turn loss and magnetization loss of a No-Insulation (RE)Ba2Cu3Ox high temperature superconductor pancake coil

    Wang, Y.; Song, H.; Yuan, W.; Jin, Z.; Hong, Z.


    This paper is to study ramping turn-to-turn loss and magnetization loss of a no-insulation (NI) high temperature superconductor (HTS) pancake coil wound with (RE)Ba2Cu3Ox (REBCO) conductors. For insulated (INS) HTS coils, a magnetization loss occurs on superconducting layers during a ramping operation. For the NI HTS coil, additional loss is generated by the "bypassing" current on the turn-to-turn metallic contacts, which is called "turn-to-turn loss" in this study. Therefore, the NI coil's ramping loss is much different from that of the INS coil, but few studies have been reported on this aspect. To analyze the ramping losses of NI coils, a numerical method is developed by coupling an equivalent circuit network model and a H-formulation finite element method model. The former model is to calculate NI coil's current distribution and turn-to-turn loss, and the latter model is to calculate the magnetization loss. A test NI pancake coil is wound with REBCO tapes and the reliability of this model is validated by experiments. Then the characteristics of the NI coil's ramping losses are studied using this coupling model. Results show that the turn-to-turn loss is much higher than the magnetization loss. The NI coil's total ramping loss is much higher than that of its insulated counterpart, which has to be considered carefully in the design and operation of NI applications. This paper also discusses the possibility to reduce NI coil's ramping loss by decreasing the ramping rate of power supply or increasing the coil's turn-to-turn resistivity.

  3. Constraint Cooling of Hot Rolled Coil

    WANG Li-juan; ZHANG Chun-li


    The layer thermal conductivity during constraint cooling of hot rolled coil was described by using equivalent thermal conductivity model and finite element method. Two radial stress concentration zones in constraint cooled coil were shown by numerical analysis, and the tension stress was assumed to be the main factor to induce stress corrosion. The experimental results show that the longer the water cooling time is, the smaller the grain size and the more uniform the grains are.




    Full Text Available This numerical research is introducing the concept of helical cone coils and their enhanced heat transfer characteristics compared to the ordinary helical coils. Helical and spiral coils are known to have better heat and mass transfer than straight tubes, which is attributed to the generation of a vortex at the helical coil known as Dean Vortex. The Dean number which is a dimensionless number used to describe the Dean vortex is a function of Reynolds number and the square root of the curvature ratio, so varying the curvature ratio for the same coil would vary the Dean number. Two scenarios were adopted to study the effect of changing the taper angle (curvature ratio on the heat transfer characteristics of the coil; the commercial software FLUENT was used in the investigation. It was found that Nusselt number increased with increasing the taper angle. A MATLAB code was built based on empirical correlation of Manlapaz and Churchill for ordinary helical coils to calculate the Nusselt number at each coil turn, and then calculate the average Nusselt number for the entire coil turns, the CFD simulation results were found acceptable when compared with the MATLAB results.

  5. AC loss measurements in HTS coil assemblies with hybrid coil structures

    Jiang, Zhenan; Long, Nicholas J.; Staines, Mike; Badcock, Rodney A.; Bumby, Chris W.; Buckley, Robert G.; Amemiya, Naoyuki


    Both AC loss and wire cost in coil windings are critical factors for high temperature superconductor (HTS) AC machinery applications. We present AC loss measurement results in three HTS coil assemblies at 77 K and 65 K which have a hybrid coil structure comprising one central winding (CW) and two end windings (EWs) wound with ReBCO and BSCCO wires with different self-field I c values at 77 K. All AC loss results in the coil assemblies are hysteretic and the normalized AC losses in the coil assemblies at different temperatures can be scaled with the I c value of the coil assemblies. The normalised results show that AC loss in a coil assembly with BSCCO CW can be reduced by using EWs wound with high I c ReBCO wires, whilst further AC loss reduction can be achieved by replacing the BSCCO CW with ReBCO CW. The results imply that a flexible hybrid coil structure is possible which considers both AC loss and wire cost in coil assemblies.

  6. A Condition for a Translation Quiver to Be a Coil

    Bin ZHU; Zong Yi HU


    We single out a class of translation quivers and prove combinatorially that the translationquivers in this class are coils. These coils form a class of special coils. They are easier to visualize, butstill show all the strange behaviour of general coils, and contain quasi-stable tubes as special examples.

  7. A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3.

    Simpson, Raina J Y; Yi Lee, Stella Hoi; Bartle, Natalie; Sum, Eleanor Y; Visvader, Jane E; Matthews, Jacqueline M; Mackay, Joel P; Crossley, Merlin


    Classic zinc finger domains (cZFs) consist of a beta-hairpin followed by an alpha-helix. They are among the most abundant of all protein domains and are often found in tandem arrays in DNA-binding proteins, with each finger contributing an alpha-helix to effect sequence-specific DNA recognition. Lone cZFs, not found in tandem arrays, have been postulated to function in protein interactions. We have studied the transcriptional co-regulator Friend of GATA (FOG), which contains nine zinc fingers. We have discovered that the third cZF of FOG contacts a coiled-coil domain in the centrosomal protein transforming acidic coiled-coil 3 (TACC3). Although FOG-ZF3 exhibited low solubility, we have used a combination of mutational mapping and protein engineering to generate a derivative that was suitable for in vitro and structural analysis. We report that the alpha-helix of FOG-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil. Remarkably, the alpha-helical surface utilized by FOG-ZF3 is the same surface responsible for the well established sequence-specific DNA-binding properties of many other cZFs. Our data demonstrate the versatility of cZFs and have implications for the analysis of many as yet uncharacterized cZF proteins.

  8. Embroidered Coils for Magnetic Resonance Sensors

    Michael I. Newton


    Full Text Available Magnetic resonance imaging is a widely used technique for medical and materials imaging. Even though the objects being imaged are often irregularly shaped, suitable coils permitting the measurement of the radio-frequency signal in these systems are usually made of solid copper. One problem often encountered is how to ensure the coils are both in close proximity and conformal to the object being imaged. Whilst embroidered conductive threads have previously been used as antennae in mobile telecommunications applications, they have not previously been reported for use within magnetic resonance. In this paper we show that an embroidered single loop coil can be used in a commercial unilateral nuclear magnetic resonance system as an alternative to a solid copper. Data is presented showing the determination of both longitudinal (T1 and effective transverse (T2eff relaxation times for a flat fabric coil and the same coil conformed to an 8 cm diameter cylinder. We thereby demonstrate the principles required for the wider use of fabric based conformal coils within nuclear magnetic resonance and magnetic resonance imaging.

  9. Stacked magnetic resonators for MRI RF coils decoupling

    Georget, Elodie; Luong, Michel; Vignaud, Alexandre; Giacomini, Eric; Chazel, Edouard; Ferrand, Guillaume; Amadon, Alexis; Mauconduit, Franck; Enoch, Stefan; Tayeb, Gérard; Bonod, Nicolas; Poupon, Cyril; Abdeddaim, Redha


    Parallel transmission is a very promising method to tackle B1+ field inhomogeneities at ultrahigh field in magnetic resonant imaging (MRI). This technique is however limited by the mutual coupling between the radiating elements. Here we propose to solve this problem by designing a passive magneto-electric resonator that we here refer to as stacked magnetic resonator (SMR). By combining numerical and experimental methodologies, we prove that this novelty passive solution allows an efficient decoupling of elements of a phased-array coil. We demonstrate the ability of this technique to significantly reduce by more than 10 dB the coupling preserving the quality of images compared to ideally isolated linear resonators on a spherical salty agar gel phantom in a 7 T MRI scanner.

  10. Solid catalytic growth mechanism of micro-coiled carbon fibers


    Micro-coiled carbon fibers were prepared by catalytic pyrolysisof acetylene with nano-sized nickel powder catalyst using the substrate method. The morphology of micro-coiled carbon fibers was observed through field emission scanning electron microscopy. It was found that the fiber and coil diameter of the obtained micro-coiled carbon fibers is about 500—600 nm and 4—5 μm, respectively. Most of the micro-coiled carbon fibers obtained were regular double carbon coils, but a few irregular ones were also observed. On the basis of the experimental observation, a solid catalytic growth mechanism of micro-coiled carbon fibers was proposed.

  11. Minimum Inductance Optimal Design for the Gradient Coil


    In MRI (Magnetic Resonance Imaging), a crucial role of gradient coils is to image organism, meanwhile the inductance of the coils determines the speed of imaging. So it is of great importance to optimize designs of the gradient coils. The target field approach is an effective method to design the gradient coils. Having applied this method and performing many numerical tests, we achieved the designs of the x-、y-、z- gradient coils , with the linearity of the fields generated by the coils in a sphere of radius 0.30 m less than 5%, in which the inductance and resistance of the coils also meet the requirements.

  12. Design And Construction Of Wireless Charging System Using Inductive Coupling

    Do Lam Mung


    Full Text Available Abstract Wireless charging system described by using the method of inductive coupling. In this project oscillation circuit converts DC energy to AC energytransmitter coil to transmit magnetic field by passing frequency and then induce the receiver coil. The properties of Induction coupling are wavemagnetic field-wideband rangevery shortcm efficiencyhight and operation frequencyLF-bandseveral handred kHz.The project shows as a small charging for 5V battery of phone in this method. The system bases on coupling magnetic field then designed and constructed as two parts. There are transmitter part and receiver part. The transmitter coil transmitter part transmits coupling magnetic field to receiver coil receiver part by passing frequency at about 1.67MHz. The Amperes law Biot-Savart law and Faraday law are used to calculate the inductive coupling between the transmitter coil and the receiver coil. The calculation of this law shows how many power transfer in receiver part when how many distance between the transmitter coil and the receiver coil. The system is safe for users and neighbouring electronic devices. To get more accurate wireless charging system it needs to change the design of the following keywords.

  13. Surgical management of an ACM aneurysm eight years after coiling.

    Pogády, P; Fellner, F; Trenkler, J; Wurm, G


    The authors present a case report on rebleeding of a medial cerebral aneurysm (MCA) eight years after complete endovascular coiling. The primarily successfully coiled MCA aneurysm showed a local regrowth which, however, was not the source of the rebleeding. The angiogram demonstrated no evidence of contrast filling of the coiled segment, but according to intraoperative findings (haematoma location, displacement of coils, evident place of rupture) there is no doubt that the coiled segment of the aneurysm was responsible for the haemorrhage.

  14. Cholera toxin B subunit-five-stranded α-helical coiled-coil fusion protein: "five-to-five" molecular chimera displays robust physicochemical stability.

    Arakawa, Takeshi; Harakuni, Tetsuya


    To create a physicochemically stable cholera toxin (CT) B subunit (CTB), it was fused to the five-stranded α-helical coiled-coil domain of cartilage oligomeric matrix protein (COMP). The chimeric fusion protein (CTB-COMP) was expressed in Pichia pastoris, predominantly as a pentamer, and retained its affinity for the monosialoganglioside GM1, a natural receptor of CT. The fusion protein displayed thermostability, tolerating the boiling temperature of water for 10min, whereas unfused CTB readily dissociated to its monomers and lost its affinity for GM1. The fusion protein also displayed resistance to strong acid at pHs as low as 0.1, and to the protein denaturant sodium dodecyl sulfate at concentrations up to 10%. Intranasal administration of the fusion protein to mice induced anti-B subunit serum IgG, even after the protein was boiled, whereas unfused CTB showed no thermostable mucosal immunogenicity. This study demonstrates that CTB fused to a pentameric α-helical coiled coil has a novel physicochemical phenotype, which may provide important insight into the molecular design of enterotoxin-B-subunit-based vaccines and vaccine delivery molecules.

  15. Quench Protection of DI-BSCCO Coil

    Yamaguchi, T.; Ueno, E.; Kato, T.; Hayashi, K.

    Quench protection is one of the most important requirements for the practical application of high-temperature-superconducting (HTS) coils. Quench protection requires that early detection of a developing quench event is followed by rapid reduction of the operating current. However, such quench detection is very difficult because HTS wire produces heat only locally due to the very slow propagation velocity of a normal zone. Excellent high voltage insulation performance is required if the current is to be reduced rapidly in a large-scale superconducting application with very large inductance. Thus it is important to investigate the behavior of coils with various decay time constants, and to detect voltages on very short time scales. This goal remains to be achieved. In the present study we built test coil and a full-scale pole coil for a 20 MW motor for use in experiments on quench protection, and parameterized the relation between the decay time constant and the detecting voltage, using a conventional balance circuit to detect the quench, which was generated by gradually raising the temperature of the coils. The results verify that a balance circuit can be used for quench detection. For example, when the current decay time constant is 4 seconds, the test coil can be protected even with a detecting voltage of 0.15 volts, despite a significant heat production rate of 126 W. We also confirmed that the full-scale pole coil, with a decay time constant of 20 seconds, can be protected with a detecting voltage of 0.06 V.

  16. Magnetic-field sensing coil embedded in ceramic for measuring ambient magnetic field

    Takahashi, Hironori


    A magnetic pick-up coil for measuring magnetic field with high specific sensitivity, optionally with an electrostatic shield (24), having coupling elements (22) with high winding packing ratio, oriented in multiple directions, and embedded in ceramic material for structural support and electrical insulation. Elements of the coil are constructed from green ceramic sheets (200) and metallic ink deposited on surfaces and in via holes of the ceramic sheets. The ceramic sheets and the metallic ink are co-fired to create a monolithic hard ceramic body (20) with metallized traces embedded in, and placed on exterior surfaces of, the hard ceramic body. The compact and rugged coil can be used in a variety of environments, including hostile conditions involving ultra-high vacuum, high temperatures, nuclear and optical radiation, chemical reactions, and physically demanding surroundings, occurring either individually or in combinations.

  17. In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions

    Yang, J.


    This thesis presents another approach for direct cytosolic delivery via membrane fusion. This approach is based on a complementary pair of coiled-coil forming peptides, K (KIAALKE)4 and E (EIAALEK)4 and is mimicking the action of the SNARE-complex. The SNARE-complex is responsible for fusion between

  18. Growth Factor Tethering to Protein Nanoparticles via Coiled-Coil Formation for Targeted Drug Delivery.

    Assal, Yasmine; Mizuguchi, Yoshinori; Mie, Masayasu; Kobatake, Eiry


    Protein-based nanoparticles are attractive carriers for drug delivery because they are biodegradable and can be genetically designed. Moreover, modification of protein-based nanoparticles with cell-specific ligands allows for active targeting abilities. Previously, we developed protein nanoparticles comprising genetically engineered elastin-like polypeptides (ELPs) with fused polyaspartic acid tails (ELP-D). Epidermal growth factor (EGF) was displayed on the surface of the ELP-D nanoparticles via genetic design to allow for active cell-targeting abilities. Herein, we focused on the coiled-coil structural motif as a means for noncovalent tethering of growth factor to ELP-D. Specifically, two peptides known to form a heterodimer via a coiled-coil structural motif were fused to ELP-D and single-chain vascular endothelial growth factor (scVEGF121), to facilitate noncovalent tethering upon formation of the heterodimer coiled-coil structure. Drug-loaded growth factor-tethered ELP-Ds were found to be effective against cancer cells by provoking cell apoptosis. These results demonstrate that tethering growth factor to protein nanoparticles through coiled-coil formation yields a promising biomaterial candidate for targeted drug delivery.

  19. An iterative method for coil sensitivity estimation in multi-coil MRI systems.

    Ling, Qiang; Li, Zhaohui; Song, Kaikai; Li, Feng


    This paper presents an iterative coil sensitivity estimation method for multi-coil MRI systems. The proposed method works with coil images in the magnitude image domain. It determines a region of support (RoS), a region being composed of the same type of tissues, by a region growing algorithm, which makes use of both intensities and intensity gradients of pixels. By repeating this procedure, it can determine multiple regions of support, which together cover most of the concerned image area. The union of these regions of support provides a rough estimate of the sensitivity of each coil through dividing the intensities of pixels by the average intensity inside every region of support. The obtained rough coil sensitivity estimate is further approached with the product of multiple low-order polynomials, rather than a single one. The product of these polynomials provides a smooth estimate of the sensitivity of each coil. With the obtained sensitivities of coils, it can produce a better reconstructed image, which determines more correct regions of support and yields preciser estimates of the sensitivities of coils. In other words, the method can be iteratively implemented to improve the estimation performance. The proposed method was verified through both simulated data and clinical data from different body parts. The experimental results confirm the superiority of our method to some conventional methods.

  20. A coiled-coil domain acts as a molecular ruler in LPS chain length regulation

    Tuukkanen, Anne; Danciu, Iulia; Svergun, Dmitri I.; Hussain, Rohanah; Liu, Huanting; Whitfield, Chris; Naismith, James H.


    Long-chain bacterial polysaccharides play important roles in pathogenicity. In Escherichia coli O9a, a model for ABC transporter dependent polysaccharide assembly, a large extracellular carbohydrate with a narrow distribution of size is polymerized from monosaccharides by a complex of two proteins, WbdA (polymerase) and WbdD (terminating protein). Such careful control of polymerization is recurring theme in biology. Combining crystallography and small angle X-ray scattering, we show that the C-terminal domain of WbdD contains an extended coiled-coil that physically separates WbdA from the catalytic domain of WbdD. The effects of insertions and deletions within the coiled-coil region were analyzed in vivo, revealing that polymer size is controlled by varying the length of the coiled-coil domain. Thus, the coiled-coil domain of WbdD functions as a molecular ruler that, along with WbdA:WbdD stoichiometry, controls the chain length of a model bacterial polysaccharide. PMID:25504321

  1. Minimax current density gradient coils: analysis of coil performance and heating.

    Poole, Michael S; While, Peter T; Lopez, Hector Sanchez; Crozier, Stuart


    Standard gradient coils are designed by minimizing the inductance or resistance for an acceptable level of gradient field nonlinearity. Recently, a new method was proposed to minimize the maximum value of the current density in a coil additionally. The stated aim of that method was to increase the minimum wire spacing and to reduce the peak temperature in a coil for fixed efficiency. These claims are tested in this study with experimental measurements of magnetic field and temperature as well as simulations of the performance of many coils. Experimental results show a 90% increase in minimum wire spacing and 40% reduction in peak temperature for equal coil efficiency and field linearity. Simulations of many more coils indicate increase in minimum wire spacing of between 50 and 340% for the coils studied here. This method is shown to be able to increase coil efficiency when constrained by minimum wire spacing rather than switching times or total power dissipation. This increase in efficiency could be used to increase gradient strength, duty cycle, or buildability.

  2. Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins

    Sinka, Rita; Gillingham, Alison K.; Kondylis, Vangelis; Munro, Sean


    Vesicles and other carriers destined for the Golgi apparatus must be guided to the correct cisternae. Golgins, long coiled-coil proteins that localize to particular Golgi subdomains via their C termini, are candidate regulators of vesicle sorting. In this study, we report that the GRIP domain

  3. Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins

    Sinka, Rita; Gillingham, Alison K.; Kondylis, Vangelis; Munro, Sean


    Vesicles and other carriers destined for the Golgi apparatus must be guided to the correct cisternae. Golgins, long coiled-coil proteins that localize to particular Golgi subdomains via their C termini, are candidate regulators of vesicle sorting. In this study, we report that the GRIP domain golgin

  4. Advanced approaches for the characterization of a de novo designed antiparallel coiled coil peptide

    Pagel, K; Seeger, K; Seiwert, B; Villa, Alessandra; Mark, AE; Berger, S; Koksch, B


    We report here an advanced approach for the characterization of the folding pattern of a de novo designed antiparallel coiled coil peptide by high-resolution methods. Incorporation of two fluorescence labels at the C- and N-terminus of the peptide chain as well as modi. cation of two hydrophobic cor

  5. A high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry.

    Dadon, Zehavit; Samiappan, Manickasundaram; Shahar, Anat; Zarivach, Raz; Ashkenasy, Gonen


    Stable and reactive: A crystal structure at 1.35 Å of a thioester coiled-coil protein reveals high similarity to all-peptide-bond proteins. In these assemblies, the thioester bonds are kept reactive towards thiol molecules in the mixture. This enables efficient domain exchange between proteins in response to changes in folding conditions or introduction of external templates.

  6. Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding.

    Samiappan, Manickasundaram; Alasibi, Samaa; Cohen-Luria, Rivka; Shanzer, Abraham; Ashkenasy, Gonen


    Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.

  7. 4C code analysis of thermal-hydraulic transients in the KSTAR PF1 superconducting coil

    Savoldi Richard, L.; Bonifetto, R.; Chu, Y.; Kholia, A.; Park, S. H.; Lee, H. J.; Zanino, R.


    The KSTAR tokamak, in operation since 2008 at the National Fusion Research Institute in Korea, is equipped with a full superconducting magnet system including the central solenoid (CS), which is made of four symmetric pairs of coils PF1L/U-PF4L/U. Each of the CS coils is pancake wound using Nb3Sn cable-in-conduit conductors with a square Incoloy jacket. The coils are cooled with supercritical He in forced circulation at nominal 4.5 K and 5.5 bar inlet conditions. During different test campaigns the measured temperature increase due to AC losses turned out to be higher than expected, which motivates the present study. The 4C code, already validated against and applied to different types of thermal-hydraulic transients in different superconducting coils, is applied here to the thermal-hydraulic analysis of a full set of trapezoidal current pulses in the PF1 coils, with different ramp rates. We find the value of the coupling time constant nτ that best fits, at each current ramp rate, the temperature increase up to the end of the heating at the coil outlet. The agreement between computed results and the whole set of measured data, including temperatures, pressures and mass flow rates, is then shown to be very good both at the inlet and at the outlet of the coil. The nτ values needed to explain the experimental results decrease at increasing current ramp rates, consistently with the results found in the literature.

  8. Baculovirus FP25K Localization: Role of the Coiled-Coil Domain.

    Garretson, Tyler A; McCoy, Jason C; Cheng, Xiao-Wen


    Two types of viruses are produced during the baculovirus life cycle: budded virus (BV) and occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the switch from BV to ODV production. Previously, FP25K from the model alphabaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) was shown to traffic ODV envelope proteins. However, FP25K localization and the domains involved are inconclusive. Here we used a quantitative approach to study FP25K subcellular localization during infection using an AcMNPV bacmid virus that produces a functional AcMNPV FP25K-green fluorescent protein (GFP) fusion protein. During cell infection, FP25K-GFP localized primarily to the cytoplasm, particularly amorphous structures, with a small fraction being localized in the nucleus. To investigate the sequences involved in FP25K localization, an alignment of baculovirus FP25K sequences revealed that the N-terminal putative coiled-coil domain is present in all alphabaculoviruses but absent in betabaculoviruses. Structural prediction indicated a strong relatedness of AcMNPV FP25K to long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p), which contains an N-terminal coiled-coil domain responsible for cytoplasmic retention. Point mutations and deletions of this domain lead to a change in AcMNPV FP25K localization from cytoplasmic to nuclear. The coiled-coil and C-terminal deletion viruses increased BV production. Furthermore, a betabaculovirus FP25K protein lacking this N-terminal coiled-coil domain localized predominantly to the nucleus and exhibited increased BV production. These data suggest that the acquisition of this N-terminal coiled-coil domain in FP25K is important for the evolution of alphabaculoviruses. Moreover, with the divergence of preocclusion nuclear membrane breakdown in betabaculoviruses and membrane integrity in alphabaculoviruses, this domain represents an alphabaculovirus adaptation for nuclear trafficking

  9. Atomic hydrodynamics of DNA: coil-uncoil-coil transitions in a wall-bounded shear flow.

    Sandberg, William C; Wang, Guan M


    carried out computations with a zero shear rate. We show that in thermal equilibrium there is asymmetry and an atomic hydrodynamic coupling between DNA molecules and the solvent molecules but there is no coil-uncoil transition.

  10. Critical current studies of a HTS rectangular coil

    Zhong, Z. [Department of Engineering, University of Cambridge (United Kingdom); Chudy, M., E-mail: [Graduate School of Technology Management, University of Pretoria (South Africa); Institute of Power and Applied Electrical Engineering, Slovak University of Technology in Bratislava (Slovakia); Ruiz, H.S. [Department of Engineering, University of Leicester, Leicester LE1 7RH (United Kingdom); Zhang, X.; Coombs, T. [Department of Engineering, University of Cambridge (United Kingdom)


    Highlights: • Unique square pancake coil was manufactured. • Measurements in relatively high magnetic field were performed. • Different sections of the coil were characterized. • Parts of the coil which are limiting critical current were identified. - Abstract: Nowadays, superconducting high field magnets are used in numerous applications due to their superior properties. High temperature superconductors (HTS) are usually used for production of circular pancake or racetrack coils. However different geometries of HTS coils might be required for some specific applications. In this study, the HTS coil wound on a rectangular frame was fully characterized in homogeneous DC background field. The study contains measurements of critical current angular dependencies. The critical current of the entire coil and two selected strands under different magnitudes and orientations of external magnetic fields are measured. The critical regions of the coil in different angular regimes are determined. This study brings better understanding of the in- field performance of HTS coils wound on frames with right-angles.

  11. Fabrication of the planar coils for WENDELSTEIN 7-X

    Viebke, H. [Max-Planck-Institut fuer Plasmaphysik, Greifswald Branch, Euratom Association, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)]. E-mail:; Rummel, Th. [Max-Planck-Institut fuer Plasmaphysik, Greifswald Branch, Euratom Association, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Risse, K. [Max-Planck-Institut fuer Plasmaphysik, Greifswald Branch, Euratom Association, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Schroeder, R. [Max-Planck-Institut fuer Plasmaphysik, Greifswald Branch, Euratom Association, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Winter, R. [Tesla Engineering Ltd., Water Lane, Storrington, Sussex RH20 3EA (United Kingdom)


    WENDELSTEIN 7-X (W7-X) is a superconducting stellarator, which uses 50 non-planar coils for the main field and 20 planar coils to modify the magnetic configuration. The planar coils are cut into two differently shaped types and designed for 3 T on the plasma axis. A planar coil has an outer diameter of around 4 m. The main elements of planar coils are the winding package, the coil case, the interlayer joints to connect the double layers, and the case cooling with instrumentation. The connection to the coil support structure is performed through forged blocks welded to the casing and bolts. The manufacturing is being performed with a high accuracy to maintain the required symmetry of the magnetic configuration of W7-X. Prior to dispatch the coils pass a works acceptance test at Tesla. After production, all coils are subjected to a functional test at cryogenic temperatures at the Low Temperature Laboratory of CEA at Saclay.

  12. Detection of laser-induced nanosecond ultrasonic pulses in metals using a pancake coil and a piezoelectric sensor.

    Kozhushko, Victor V; Krenn, Heinz


    A piezoelectric sensor and a pancake coil sensor were used for broadband detection of laser-induced ultrasound in single-crystal aluminum and polycrystalline nickel. Pressure pulses with pronounced compression phases were induced by laser pulses of 5 ns duration from one side of the specimens and detected from the opposite side. A coupling layer of water was required for the piezoelectric method, whereas the pancake coil placed in the biasing permanent field of a cylindrical magnet ~0.25 T allowed noncontact detection. The signals detected by a piezoelectric transducer showed bipolar form and their spectra covered the range from 5 to 90 MHz. The signal measured in aluminum by a pancake coil was assigned to the eddy current sources and had single polarity. The peak-to-peak value of the signal in nickel was higher and had bipolar form because of the inverse magnetostrictive effect. The high-frequency limit detected by the pancake coil approached 200 MHz.

  13. Surface Coil for Magnetic Resonance Imaging

    Beatriz Taimy Ricardo Ferro


    Full Text Available Currently Magnetic Resonance Imaging (MRI, has become a vital tool for the clinical diagnosis of various diseases, especially in the Nervisos Central System and the Musculos keletal System. Coils(RF are an essential component in the generation of these images, are responsible for exciting thespins of nuclei in a sample and/or detect the resultant signal coming from them. The use of surface RF coils has increased considerably, because they have a high signal to noise ratio, a parameter that defines the quality of the image. In the present work, there was realized the theoretical design and practical implementation of a circular surface RF coil. The experimental prototype was optimized to be used in the tomograph Giroimag03  built in Medical Biophysics Center

  14. Determination of Coil Inductances Cylindrical Iron Nucleus

    Azeddine Mazouz


    Full Text Available The paper describes the investigation and development of a structure and performance characteristics of a coil iron nucleus cylindrical (C.I.N.C. The coil iron nucleus cylindrical is a nonlinear electro radio in which the moving of the nucleus in a sense or in other causes change in inductance and can reach extreme values at the superposition of nucleus and coil centers. The variation of the inductance and the degree of freedom of movement of the nucleus can lead to a device with electromechanical conversion The aim of this paper is the determination and visualization of self inductance and mutual of the (C.I.N.C based on geometric dimensions and the displacement of the nucleus.  

  15. CS model coil experimental log book

    Nishijima, Gen; Sugimoto, Makoto; Nunoya, Yoshihiko; Wakabayashi, Hiroshi; Tsuji, Hiroshi [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment


    Charging test of the ITER CS Model Coil which is the world's largest superconducting pulse coil and the CS Insert Coil had started at April 11, 2000 and had completed at August 18, 2000. In the campaign, total shot numbers were 356 and the size of the data file in the DAS (Data Acquisition System) was over 20 GB. This report is a database that consists of the log list and the log sheets of every shot. One can access the database, make a search, and browse results via Internet ( The database will be useful to quick search to choose necessary shots. (author)

  16. Acoustic rainbow trapping by coiling up space

    Ni, Xu


    We numerically realize the acoustic rainbow trapping effect by tapping an air waveguide with space-coiling metamaterials. Due to the high refractive-index of the space-coiling metamaterials, our device is more compact compared to the reported trapped-rainbow devices. A numerical model utilizing effective parameters is also calculated, whose results are consistent well with the direct numerical simulation of space-coiling structure. Moreover, such device with the capability of dropping different frequency components of a broadband incident temporal acoustic signal into different channels can function as an acoustic wavelength division de-multiplexer. These results may have potential applications in acoustic device design such as an acoustic filter and an artificial cochlea.

  17. Measuring the orthogonality error of coil systems

    Heilig, B.; Csontos, A.; Pajunpää, K.; White, Tim; St. Louis, B.; Calp, D.


    Recently, a simple method was proposed for the determination of pitch angle between two coil axes by means of a total field magnetometer. The method is applicable when the homogeneous volume in the centre of the coil system is large enough to accommodate the total field sensor. Orthogonality of calibration coil systems used for calibrating vector magnetometers can be attained by this procedure. In addition, the method can be easily automated and applied to the calibration of delta inclination–delta declination (dIdD) magnetometers. The method was tested by several independent research groups, having a variety of test equipment, and located at differing geomagnetic observatories, including: Nurmijärvi, Finland; Hermanus, South Africa; Ottawa, Canada; Tihany, Hungary. This paper summarizes the test results, and discusses the advantages and limitations of the method.

  18. MFTF test coil construction and performance

    Cornish, D.N.; Zbasnik, J.P.; Leber, R.L.; Hirzel, D.G.; Johnston, J.E.; Rosdahl, A.R.


    A solenoid coil, 105 cm inside the 167 cm outside diameter, has been constructed and tested to study the performance of the stabilized Nb--Ti conductor to be used in the Mirror Fusion Test Facility (MFTF) being built at Lawrence Livermore Laboratory. The insulation system of the test coil is identical to that envisioned for MFTF. Cold-weld joints were made in the conductor at the start and finish of each layer; heaters were fitted to some of these joints and also to the conductor at various locations in the winding. This paper gives details of the construction of the coil and the results of the tests carried out to determine its propagation and recovery characteristics.

  19. Resistive demountable toroidal-field coils for tokamak reactors

    Jassby, D.L.; Jacobsen, R.A.; Kalnavarns, J.; Masson, L.S.; Sekot, J.P.


    Readily demountable TF (toroidal-field) coils allow complete access to the internal components of a tokamak reactor for maintenance of replacement. The requirement of readily demountable joints dictates the use of water-cooled resistive coils, which have a host of decisive advantages over superconducting coils. Previous papers have shown that resistive TF coils for tokamak reactors can operate in the steady state with acceptable power dissipation (typically, 175 to 300 MW). This paper summarizes results of parametric studies of size optimization of rectangular TF coils and of a finite-element stress analysis, and examines several candidate methods of implementing demountable joints for rectangular coils constructed of plate segments.

  20. Analytical and experimental analysis of tube coil heat exchanger

    Smusz, R.


    The paper presents the analytical and experimental analysis of heat transfer for the finned tube coil heat exchanger immersed in thermal storage tank. The tank is equipped with three helical-shaped heating coils and cylindrical- shaped stratification device. Two coils, upper and lower, use the water as a heating medium. The third, double wall heat exchanger coil, located at the bottom head on the tank is filled by the refrigerant (freon). Calculations of thermal power of water coil were made. Correlations of heat transfer coefficients in curved tubes were applied. In order to verify the analytical calculations the experimental studies of heat transfer characteristic for coil heat exchanger were performed.

  1. Final design and construction of the Wendelstein7-X coils

    Wegener, L. E-mail:; Feist, J.-H.; Sapper, J.; Kerl, F.; Werner, F


    The Stellarator of the Wendelstein 7-X (W7-X) experiment contains a system of 50 non-planar and 20 planar superconducting coils. The coils were designed by the IPP. The coil manufacturing and inspection is shared between several European enterprises and consortiums. The coils consist of the winding pack embedded in a stainless steel casing and of the related instrumentation. Design details, tolerances and guarantee values and differences between the coils types are described in the contribution. The features of the superconductor are described separately. Finally, the contribution indicates measures adopted by the W7-X project to ensure the quality of the coil design and manufacturing.

  2. Coiled coil interactions for the targeting of liposomes for nucleic acid delivery

    Oude Blenke, Erik E.; van den Dikkenberg, Joep; van Kolck, Bartjan; Kros, Alexander; Mastrobattista, Enrico


    Coiled coil interactions are strong protein-protein interactions that are involved in many biological processes, including intracellular trafficking and membrane fusion. A synthetic heterodimeric coiled-coil forming peptide pair, known as E3 (EIAALEK)3 and K3 (KIAALKE)3 was used to functionalize liposomes encapsulating a splice correcting oligonucleotide or siRNA. These peptide-functionalized vesicles are highly stable in solution but start to cluster when vesicles modified with complementary peptides are mixed together, demonstrating that the peptides quickly coil and crosslink the vesicles. When one of the peptides was anchored to the cell membrane using a hydrophobic cholesterol anchor, vesicles functionalized with the complementary peptide could be docked to these cells, whereas non-functionalized cells did not show any vesicle tethering. Although the anchored peptides do not have a downstream signaling pathway, microscopy pictures revealed that after four hours, the majority of the docked vesicles were internalized by endocytosis. Finally, for the first time, it was shown that the coiled coil assembly at the interface between the vesicles and the cell membrane induces active uptake and leads to cytosolic delivery of the nucleic acid cargo. Both the siRNA and the splice correcting oligonucleotide were functionally delivered, resulting respectively in the silencing or recovery of luciferase expression in the appropriate cell lines. These results demonstrate that the docking to the cell by coiled coil interaction can induce active uptake and achieve the successful intracellular delivery of otherwise membrane impermeable nucleic acids in a highly specific manner.Coiled coil interactions are strong protein-protein interactions that are involved in many biological processes, including intracellular trafficking and membrane fusion. A synthetic heterodimeric coiled-coil forming peptide pair, known as E3 (EIAALEK)3 and K3 (KIAALKE)3 was used to functionalize liposomes

  3. Self-assembling segmented coiled tubing

    Raymond, David W.


    Self-assembling segmented coiled tubing is a concept that allows the strength of thick-wall rigid pipe, and the flexibility of thin-wall tubing, to be realized in a single design. The primary use is for a drillstring tubular, but it has potential for other applications requiring transmission of mechanical loads (forces and torques) through an initially coiled tubular. The concept uses a spring-loaded spherical `ball-and-socket` type joint to interconnect two or more short, rigid segments of pipe. Use of an optional snap ring allows the joint to be permanently made, in a `self-assembling` manner.

  4. Multiple coil closure of isolated aortopulmonary collateral

    Padhi Sumanta


    Full Text Available A 7-month-old girl was diagnosed to have large aortopulmonary collateral during evaluation for congestive heart failure. There was no other evidence of cardiopulmonary disease. The collateral was successfully closed with multiple coils delivered sequentially. We describe the issues associated during closure of the aortopulmonary collateral in this case. To the best of our knowledge, this is the first reported case of large aortopulmonary collateral presenting with heart failure in an otherwise structurally normal heart that was closed successfully with multiple coils delivered sequentially.

  5. A HTS dipole insert coil constructed

    Ballarino, A; Rey, J M; Stenvall, A; Sorbi, M; Tixador, P


    This report is the deliverable report 7.4.1 “A HTS dipole insert coil constructed“. The report has three parts: “Design report for the HTS dipole insert”, “One insert pancake prototype coil constructed with the setup for a high field test”, and “All insert components ordered”. The three report parts show that, although the insert construction will be only completed by end 2013, all elements are present for a successful completion and that, given the important investments done by the participants, there is a full commitment of all of them to finish the project

  6. Estimation and measurement of flat or solenoidal coil inductance for radiofrequency NMR coil design.

    Rainey, Jan K; DeVries, Jeffrey S; Sykes, Brian D


    The inductance of a radiofrequency coil determines its compatibility with a given NMR probe circuit. However, calculation (or estimation) of inductance for radiofrequency coils of dimensions suitable for use in an NMR probe is not trivial, particularly for flat-coils. A comparison of a number of formulae for calculation of inductance is presented through the use of a straightforward inductance measurement circuit. This technique relies upon instrumentation available in many NMR laboratories rather than upon more expensive and specialized instrumentation often utilized in the literature. Inductance estimation methods are suggested and validated for both flat-coils and solenoids. These have proven very useful for fabrication of a number of new coils in our laboratory for use in static solid-state NMR probes operating at (1)H frequencies of 300 and 600MHz. Solenoidal coils with very similar measured and estimated inductances having inner diameters from 1 to 5mm are directly compared as an example of the practical application of inductance estimation for interchange of coils within an existing solid-state NMR probe.

  7. Research and development of MRI surface coil for TMJ MR imaging; Modulated Helmholtz surface coil

    Kukimoto, Yoshiaki; Kukimoto, Kyoko (Kameda General Hospital, Kamogawa, Chiba (Japan)); Shirakawa, Toyomi


    Internal derangements of the temporomandibular joint (TMJ) are a major cause of jaw pain and dysfunction as well as other related clinical symptoms. TMJ diagnosis is the abnormal position and appearance of the disk. Most X-ray-based methods are useful for evaluating bony abnormalities, but their reduced soft-tissue contrast often makes the diagnostic evaluation of TMJ disorders difficult. Magnetic resonance (MR) imaging is a very recent addition to the medical diagnostic of TMJ diseases. MR imaging can produce high-quality tomographic images of greater soft-tissue contrast without ionizing radiation or known biological hazards. MR system was circular type Simens Magnetom 1.5 tesla. Display matrix was 256x256. A Modulated Helmholtz type coil of 17 cm in diameter was developed in Kameda General Hospital in order to increase signal to noise ratio in the area of bilateral TMJs. The distance between two coils was 16-20 cm. The head was placed in supine position in the center of two surface coils. A Modulated Helmholtz type coil: 1. Modulated Helmholtz type coil was used as an emitter and a receiver. 2. Modulated Helmholtz type coil had a pair of 17 cm coils, which were movable according to head width of each patient. 3. MR imaging of bilateral TMJs was taken at once because of no necessity to reset a surfacecoil. 4. It was easy to set positioning of the head. (author).

  8. Energy Harvesting with Coupled Magnetorestrictive Resonators


    Guyomar, and B. Ducharne. 2011. “Simulation of a Duffing Oscillator for Broadband Piezoelectric Energy Harvesting,” Smart Materials and Structures, vol...electromagnetic technique includes suspended magnets in a coil or a suspended coil in a magnet array that oscillates as it is excited with vibrational motion...coupled systems of non-linear oscillators improve the performance of sensors by increasing sensitivity [1]. This concept can be used to harvest more

  9. Tx/Rx Head Coil Induces Less RF Transmit-Related Heating than Body Coil in Conductive Metallic Objects Outside the Active Area of the Head Coil.

    Nagy, Zoltan; Oliver-Taylor, Aaron; Kuehne, Andre; Goluch, Sigrun; Weiskopf, Nikolaus


    The transmit-receive (Tx/Rx) birdcage head coil is often used for excitation instead of the body coil because of the presumably lower risk of heating in and around conductive implants. However, this common practice has not been systematically tested. To investigate whether the Tx/Rx birdcage head coil produces less heating than the body coil when scanning individuals with implants, we used a 3T clinical scanner and made temperature measurements around a straight 15 cm conductor using either the Tx/Rx body or the head coil for excitation. Additionally, the transmitted fields of a Tx/Rx head coil were measured both in air and in gel using a resonant and a non-resonant B field probes as well as a non-resonant E field probe. Simulations using a finite-difference time domain solver were compared with the experimental findings. When the body coil was used for excitation, we observed heating around the 15 cm wire at various anatomical locations (both within and outside of the active volume of the head coil). Outside its active area, no such heating was observed while using the Tx/Rx head coil for excitation. The E and B fields of the Tx/Rx birdcage head coil extended well-beyond the physical dimensions of the coil. In air, the fields were monotonically decreasing, while in gel they were more complex with local maxima at the end of the ASTM phantom. These experimental findings were line with the simulations. While caution must always be exercised when scanning individuals with metallic implants, these findings support the use of the Tx/Rx birdcage head coil in place of the body coil at 3T in order to reduce the risk of heating in and around conductive implants that are remote from the head coil.

  10. Tx/Rx Head Coil Induces Less RF Transmit-Related Heating than Body Coil in Conductive Metallic Objects Outside the Active Area of the Head Coil

    Nagy, Zoltan; Oliver-Taylor, Aaron; Kuehne, Andre; Goluch, Sigrun; Weiskopf, Nikolaus


    The transmit–receive (Tx/Rx) birdcage head coil is often used for excitation instead of the body coil because of the presumably lower risk of heating in and around conductive implants. However, this common practice has not been systematically tested. To investigate whether the Tx/Rx birdcage head coil produces less heating than the body coil when scanning individuals with implants, we used a 3T clinical scanner and made temperature measurements around a straight 15 cm conductor using either the Tx/Rx body or the head coil for excitation. Additionally, the transmitted fields of a Tx/Rx head coil were measured both in air and in gel using a resonant and a non-resonant B field probes as well as a non-resonant E field probe. Simulations using a finite-difference time domain solver were compared with the experimental findings. When the body coil was used for excitation, we observed heating around the 15 cm wire at various anatomical locations (both within and outside of the active volume of the head coil). Outside its active area, no such heating was observed while using the Tx/Rx head coil for excitation. The E and B fields of the Tx/Rx birdcage head coil extended well-beyond the physical dimensions of the coil. In air, the fields were monotonically decreasing, while in gel they were more complex with local maxima at the end of the ASTM phantom. These experimental findings were line with the simulations. While caution must always be exercised when scanning individuals with metallic implants, these findings support the use of the Tx/Rx birdcage head coil in place of the body coil at 3T in order to reduce the risk of heating in and around conductive implants that are remote from the head coil.

  11. Transient Analysis of Air-Core Coils by Moment Method

    Fujita, Akira; Kato, Shohei; Hirai, Takao; Okabe, Shigemitu

    In electric power system a threat of lighting surge is decreased by using ground wire and arrester, but the risk of failure of transformer is still high. Winding is the most familiar conductor configuration of electromagnetic field components such as transformer, resistors, reactance device etc. Therefore, it is important that we invest the lighting surge how to advance into winding, but the electromagnet coupling in a winding makes lighting surge analysis difficult. In this paper we present transient characteristics analysis of an air-core coils by moment method in frequency domain. We calculate the inductance from time response and impedance in low frequency, and compare them with the analytical equation which is based on Nagaoka factor.

  12. Tokamak Plasmas : Mirnov coil data analysis for tokamak ADITYA

    D Raju; R Jha; P K Kaw; S K Mattoo; Y C Saxena; Aditya Team


    The spatial and temporal structures of magnetic signal in the tokamak ADITYA is analysed using recently developed singular value decomposition (SVD) technique. The analysis technique is first tested with simulated data and then applied to the ADITYA Mirnov coil data to determine the structure of current peturbation as the discharge progresses. It is observed that during the current rise phase, current perturbation undergoes transition from = 5 poloidal structure to = 4 and then to = 3. At the time of current termination, = 2 perturbation is observed. It is observed that the mode frequency remains nearly constant (≈10 kHz) when poloidal mode structure changes from = 4 to = 2. This may be either an indication of mode coupling or a consequences of changes in the plasma electron temperature and density scale length.

  13. Probing Mechanical Resonances in Cantilevered Coiled Carbon Nanowires

    Saini, Deepika; Dickel, Doyl; Behlow, Herbert; Pillai, Balu; Yang, Keqin; Skove, Malcolm; Serkiz, Steven; Rao, Apparao; Clemson University Team; Savannah River National Laboratory Team


    Helically coiled carbon nanowires (CCNW) and nanotubes are promising elements for use in MEMS/NEMS devices and nanorobotics, as nano-inductors and sensors, and for impact protection (e.g. Bell et al. 2007 IEEE International Conference, J. Appl. Phys. 100, 064309 (2006)). Understanding and characterizing their mechanical resonance behavior is essential for the reliability in applications. In this study, we have electrically actuated an individual CCNW in a diving-board cantilever configuration inside a scanning electron microscope, and electrically detected its mechanical resonance modes. By oscillation at low frequency we confirmed the induced-charge actuation mechanism. Among the modes we observed, some appeared to have both axial and lateral components. We also observed closely spaced resonance modes which we attribute to the splitting of degenerate modes, consistent with our COMSOL simulations. We suggest that the helical morphology facilitates inter-mode coupling that results in the observed complex resonance behavior.

  14. Ballistocardiogram of avian eggs determined by an electromagnetic induction coil.

    Ono, H; Akiyama, R; Sakamoto, Y; Pearson, J T; Tazawa, H


    As an avian embryo grows within an eggshell, the whole egg is moved by embryonic activity and also by the embryonic heartbeat. A technical interest in detecting minute biological movements has prompted the development of techniques and systems to measure the cardiogenic ballistic movement of the egg or ballistocardiogram (BCG). In this context, there is interest in using an electromagnetic induction coil (solenoid) as another simple sensor to measure the BCG and examining its possibility for BCG measurement. A small permanent magnet is attached tightly to the surface of an incubated egg, and then the egg with the magnet is placed in a solenoid. Preliminary model analysis is made to design a setup of the egg, magnet and solenoid coupling system. Then, simultaneous measurement with a laser displacement measuring system, developed previously, is made for chicken eggs, indicating that the solenoid detects the minute cardiogenic ballistic movements and that the BCG determined is a measure of the velocity of egg movements.

  15. Application of Inductively Coupled Wireless Radio Frequency Probe to Knee Joint in Magnetic Resonance Image

    Shigehiro Hashimoto


    Full Text Available An inductively coupled wireless coil for a radio frequency (RF probe has been designed and applied to a human knee joint to improve the signal to noise ratio (SNR in a magnetic resonance image (MRI. A birdcage type of a primary coil and a Helmholtz type of a wireless secondary coil have been manufactured. The coils were applied to a human knee with a 3 T MRI system. SNR was calculated both in the proton density image and in the T2 weighted image of MRI. The experimental results show that the designed coils are effective to increase SNR in the human knee MRI.

  16. Optimization of a conduction-cooled LTS pulse coil

    Kawagoe, A. [Kagoshima University, Kohrimoto 1-21-40, Kagoshima-shi, Kagoshima 890-0065 (Japan)]. E-mail:; Yamamuro, H. [Kagoshima University, Kohrimoto 1-21-40, Kagoshima-shi, Kagoshima 890-0065 (Japan); Sumiyoshi, F. [Kagoshima University, Kohrimoto 1-21-40, Kagoshima-shi, Kagoshima 890-0065 (Japan); Mito, T. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Chikaraishi, H. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Hemmi, T. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Baba, T. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Yokota, M. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Morita, Y. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Ogawa, H. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Abe, R. [Shibuya Kogyo Co., Ltd., Kanazawa, Ishikawa 920-0054 (Japan); Okumura, K. [Technova Inc., Chiyoda-ku, Tokyo 100-0011 (Japan); Iwakuma, M. [Kyushu University, Higashi-ku, Fukuoka 812-8581 (Japan)


    The output limit of the available power of a prototype conduction-cooled low temperature superconducting (LTS) pulse coil is clarified for the optimization of the coil. The winding conductor of this coil is a NbTi/Cu Rutherford cable, which is extruded with aluminum. Dyneema[reg] fiber reinforced plastics (DFRP) and Litz wires are used as the spacers of this coil. A prototype coil with a stored energy of 100 kJ was successfully fabricated and tested, and the coil performed excellently. In this paper, the stability margin of this coil is clarified by thermal analysis, using a two-dimensional finite element method, taking into account the effects of both types of spacers, DFRP and Litz wires. Additionally, the maximum output power of the coil is estimated at about three times the rated output.

  17. Modular Coils and Plasma Configurations for Quasi-axisymmetric Stellarators

    L.P. Ku and A.H. Boozer


    Characteristics of modular coils for quasi-axisymmetric stellarators that are related to the plasma aspect ratio, number of field periods and rotational transform have been examined systematically. It is observed that, for a given plasma aspect ratio, the coil complexity tends to increase with the increased number of field periods. For a given number of field periods, the toroidal excursion of coil winding is reduced as the plasma aspect ratio is increased. It is also clear that the larger the coil-plasma separation is, the more complex the coils become. It is further demonstrated that it is possible to use other types of coils to complement modular coils to improve both the physics and the modular coil characteristics.

  18. Constrained length minimum inductance gradient coil design.

    Chronik, B A; Rutt, B K


    A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constraints on the final current density is presented. This constrained current minimum inductance method is derived in the context of previous target field methods. Complete details are shown and all equations required for implementation of the algorithm are given. The method has been implemented on computer and applied to the design of both a 1:1 aspect ratio (length:diameter) central ROI and a 2:1 aspect ratio edge ROI gradient coil. The 1:1 design demonstrates that a general analytic method can be used to easily obtain very short gradient coil designs for use with specialized magnet systems. The edge gradient design demonstrates that designs that allow imaging of the neck region with a head sized gradient coil can be obtained, as well as other applications requiring edge-of-cylinder regions of uniformity.

  19. Coil in bottom part of splitter magnet


    Radiation-resistant coil being bedded into the bottom part of a splitter magnet. This very particular magnet split the beam into 3 branches, for 3 target stations in the West-Area. See Annual Report 1975, p.176, Figs.14 and 15.

  20. Stellarator Coil Design and Plasma Sensitivity

    Long-Poe Ku and Allen H. Boozer


    The rich information contained in the plasma response to external magnetic perturbations can be used to help design stellarator coils more effectively. We demonstrate the feasibility by first devel- oping a simple, direct method to study perturbations in stellarators that do not break stellarator symmetry and periodicity. The method applies a small perturbation to the plasma boundary and evaluates the resulting perturbed free-boundary equilibrium to build up a sensitivity matrix for the important physics attributes of the underlying configuration. Using this sensitivity information, design methods for better stellarator coils are then developed. The procedure and a proof-of-principle application are given that (1) determine the spatial distributions of external normal magnetic field at the location of the unperturbed plasma boundary to which the plasma properties are most sen- sitive, (2) determine the distributions of external normal magnetic field that can be produced most efficiently by distant coils, (3) choose the ratios of the magnitudes of the the efficiently produced magnetic distributions so the sensitive plasma properties can be controlled. Using these methods, sets of modular coils are found for the National Compact Stellarator Experiment (NCSX) that are either smoother or can be located much farther from the plasma boundary than those of the present design.

  1. Penile hair coil strangulation of the child


    We report the case of a child with a delayed presentation of penile strangulation with a coil of hair that resulted in a complete ... erection in some of them and with autoerotic intentions in others. ... in children with underlying urological problems.

  2. High-resolution MR imaging of triangular fibrocartilage complex (TFCC): comparison of microscopy coils and a conventional small surface coil

    Yoshioka, Hiroshi [Department of Radiology, University of Tsukuba, Tsukuba (Japan); Department of Radiology, Brigham and Women' s Hospital, 75 Francis Street, 02115, Boston, MA (United States); Ueno, Teruko; Itai, Yuji [Department of Radiology, University of Tsukuba, Tsukuba (Japan); Tanaka, Toshikazu [Department of Orthopedic Surgery, Tsukuba Kinen Hospital, Tsukuba (Japan); Shindo, Masashi [Tsukuba University Hospital, Tsukuba (Japan)


    To compare MR images of the triangular fibrocartilage complex (TFCC) using microscopy coils with those using a conventional surface coil qualitatively and quantitatively. Proton density-weighted images and T2*-weighted images of the TFCC from ten normal volunteers were obtained with a conventional surface coil (C4 coil; 80 mm in diameter), a 47-mm microscopy surface coil and a 23-mm microscopy surface coil at 1.5 T. Qualitative image analysis of MR images with three coils was performed by two radiologists who assigned one of five numerical scores (0, nonvisualization; 1, poor; 2, average; 3, good; 4, excellent) for five TFCC components, which were disc proper, triangular ligament, meniscus homologue, ulnotriquetral and ulnolunate ligament. Quantitative analysis included the signal-to-noise ratio (S/N) of the disc proper of TFCC, the lunate cartilage, the lunate bone and the contrast-noise-ratio (C/N) between articular cartilage and disc proper or bone marrow were measured. All structures show higher scores qualitatively on MR with microscopy coils than those with a C4 coil, and the difference was significant with the exception of the ulnolunate ligament. MR with microscopy coils showed significantly higher S/N values than those with a conventional surface coil (P<0.05 to P<0.001). T2*-weighted images using microscopy coils showed significantly higher cartilage-disc proper C/N and cartilage-bone marrow C/N (P<0.01 to P<0.001). On proton density-weighted images, the C/N between cartilage and disc proper with two microscopy coils was significantly higher (P<0.01) than that with a conventional coil. High-resolution MR images of the normal wrist using microscopy coils were superior to those using a conventional surface coil qualitatively and quantitatively. High-resolution MR imaging with a microscopy coil would be a promising method to diagnose TFCC lesions. (orig.)

  3. Comparison of an Electromagnetic Energy Harvester Performance using Wound Coil Wire and PCB Coil

    Resali, MSM; Salleh, H.


    This paper presents the performance of two types of electromagnetic energy harvester, one using manually wound coil wire (EH-EC) and the other one using printed circuit board (PCB) coil (EH-EP). The objective of the study is to measure the corresponding output voltage and power by varying the number of coils and the position of the magnet. The experiment was conducted at a fix 50 Hz of frequency and at 0.25g of acceleration. The EH-EP was found to be more effective than the 350 turns of the wound coil wire, with maximum power of 26 μW. Overall, the performance of the EH-EC showed better result with maximum power of 125 μW for 1050 turns when compared to the EH-EP.

  4. Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for Virulence

    McNamara, Case; Zinkernagel, Annelies S.; Macheboeuf, Pauline; Cunningham, Madeleine W.; Nizet, Victor; Ghosh, Partho (UO-HSC); (UCSD)


    Antigenically variable M proteins are major virulence factors and immunogens of the human pathogen group A Streptococcus (GAS). Here, we report the -3 angstrom resolution structure of a GAS M1 fragment containing the regions responsible for eliciting type-specific, protective immunity and for binding fibrinogen, which promotes M1 proinflammatory and antiphagocytic functions. The structure revealed substantial irregularities and instabilities throughout the coiled coil of the M1 fragment. Similar structural irregularities occur in myosin and tropomyosin, explaining the patterns of cross-reactivity seen in autoimmune sequelae of GAS infection. Sequence idealization of a large segment of the M1 coiled coil enhanced stability but diminished fibrinogen binding, proinflammatory effects, and antibody cross-reactivity, whereas it left protective immunogenicity undiminished. Idealized M proteins appear to have promise as vaccine immunogens.

  5. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice.

    Bahirat, Umakant Ashok; Shenoy, Rekha Raghuveer; Goel, Rajan Naresh; Nemmani, Kumar V S


    G-protein coupled receptor 119 (GPR119) receptor is a rhodopsin-like, class A Gαs-coupled receptor, predominantly expressed in pancreatic islet cells and intestinal entero-endocrine cells. GPR119 has been emerged as a novel therapeutic target for the treatment of dyslipidemia in type 2 diabetes. In this study, we investigated the effect of APD668, a GPR119 agonist alone and in combination with linagliptin, a DPPIV inhibitor on oral fat tolerance test. Our findings demonstrate that APD668, a GPR119 agonist inhibits the intestinal triglyceride absorption after acute fat load in mice. Single dose administration of APD668 increases incretin secretion and enhances total PYY levels in presence of fat load in mice. We found that, the anti-dyslipidemic action of APD668 was reversed in presence of exendin-3 in oral fat tolerance test. In addition, our results showed that exendin-3 (9-39) failed to block the effect of APD668 on gastric emptying indicating that gastric emptying effects of APD668 are indeed mediated through GPR119 receptor dependent mechanism. Combined administration of APD668 and linagliptin significantly increased plasma active GLP-1 levels in-vivo and showed improvement in fat tolerance. However, APD668 failed to show anti-dyslipidemic activity in tyloxapol-induced hyperlipidemia in mice. Furthermore, we investigated the chronic effects of APD668 on hepatic steatosis in high trans-fat diet fed steatohepatitis model in mice. Oral administration of APD668 in HTF diet fed mice ameliorated hepatic endpoints such as plasma ALT, AST, liver weight and steatosis. These findings suggest that GPR119 agonists may represent a promising therapeutic strategy for the treatment of dyslipidemia and non-alcoholic steatohepatitis.

  6. Multiple-Coil, Pulse-Induction Metal Detector

    Lesky, Edward S.; Reid, Alan M.; Bushong, Wilton E.; Dickey, Duane P.


    Multiple-head, pulse-induction metal detector scans area of 72 feet squared with combination of eight detector heads, each 3 ft. square. Head includes large primary coil inducing current in smaller secondary coils. Array of eight heads enables searcher to cover large area quickly. Pulses applied to primary coil, induced in secondary coils measured to determine whether metal present within range of detector head. Detector designed for recovery of Space Shuttle debris.

  7. Design and Testing of Coils for Pulsed Electromagnetic Forming

    Golovashchenko, S.; Bessonov, N.; Davies, R


    Coil design influences the distribution of electromagnetic forces applied to both the blank and the coil. The required energy of the process is usually defined by deformation of the blank. However, the discharge also results in a significant amount of heat being generated and accumulating in the coil. Therefore, EMF process design involves working with three different problems: 1) propagation of an electromagnetic field through the coil-blank system and generation of pulsed electromagnetic pr...

  8. GBNV encoded movement protein (NSm) remodels ER network via C-terminal coiled coil domain

    Singh, Pratibha; Savithri, H.S., E-mail:


    Plant viruses exploit the host machinery for targeting the viral genome–movement protein complex to plasmodesmata (PD). The mechanism by which the non-structural protein m (NSm) of Groundnut bud necrosis virus (GBNV) is targeted to PD was investigated using Agrobacterium mediated transient expression of NSm and its fusion proteins in Nicotiana benthamiana. GFP:NSm formed punctuate structures that colocalized with mCherry:plasmodesmata localized protein 1a (PDLP 1a) confirming that GBNV NSm localizes to PD. Unlike in other movement proteins, the C-terminal coiled coil domain of GBNV NSm was shown to be involved in the localization of NSm to PD, as deletion of this domain resulted in the cytoplasmic localization of NSm. Treatment with Brefeldin A demonstrated the role of ER in targeting GFP NSm to PD. Furthermore, mCherry:NSm co-localized with ER–GFP (endoplasmic reticulum targeting peptide (HDEL peptide fused with GFP). Co-expression of NSm with ER–GFP showed that the ER-network was transformed into vesicles indicating that NSm interacts with ER and remodels it. Mutations in the conserved hydrophobic region of NSm (residues 130–138) did not abolish the formation of vesicles. Additionally, the conserved prolines at positions 140 and 142 were found to be essential for targeting the vesicles to the cell membrane. Further, systematic deletion of amino acid residues from N- and C-terminus demonstrated that N-terminal 203 amino acids are dispensable for the vesicle formation. On the other hand, the C-terminal coiled coil domain when expressed alone could also form vesicles. These results suggest that GBNV NSm remodels the ER network by forming vesicles via its interaction through the C-terminal coiled coil domain. Interestingly, NSm interacts with NP in vitro and coexpression of these two proteins in planta resulted in the relocalization of NP to PD and this relocalization was abolished when the N-terminal unfolded region of NSm was deleted. Thus, the NSm

  9. Compressing DNA sequence databases with coil

    Hendy Michael D


    Full Text Available Abstract Background Publicly available DNA sequence databases such as GenBank are large, and are growing at an exponential rate. The sheer volume of data being dealt with presents serious storage and data communications problems. Currently, sequence data is usually kept in large "flat files," which are then compressed using standard Lempel-Ziv (gzip compression – an approach which rarely achieves good compression ratios. While much research has been done on compressing individual DNA sequences, surprisingly little has focused on the compression of entire databases of such sequences. In this study we introduce the sequence database compression software coil. Results We have designed and implemented a portable software package, coil, for compressing and decompressing DNA sequence databases based on the idea of edit-tree coding. coil is geared towards achieving high compression ratios at the expense of execution time and memory usage during compression – the compression time represents a "one-off investment" whose cost is quickly amortised if the resulting compressed file is transmitted many times. Decompression requires little memory and is extremely fast. We demonstrate a 5% improvement in compression ratio over state-of-the-art general-purpose compression tools for a large GenBank database file containing Expressed Sequence Tag (EST data. Finally, coil can efficiently encode incremental additions to a sequence database. Conclusion coil presents a compelling alternative to conventional compression of flat files for the storage and distribution of DNA sequence databases having a narrow distribution of sequence lengths, such as EST data. Increasing compression levels for databases having a wide distribution of sequence lengths is a direction for future work.

  10. Coil-to-coil physiological noise correlations and their impact on functional MRI time-series signal-to-noise ratio.

    Triantafyllou, Christina; Polimeni, Jonathan R; Keil, Boris; Wald, Lawrence L


    Physiological nuisance fluctuations ("physiological noise") are a major contribution to the time-series signal-to-noise ratio (tSNR) of functional imaging. While thermal noise correlations between array coil elements have a well-characterized effect on the image Signal to Noise Ratio (SNR0 ), the element-to-element covariance matrix of the time-series fluctuations has not yet been analyzed. We examine this effect with a goal of ultimately improving the combination of multichannel array data. We extend the theoretical relationship between tSNR and SNR0 to include a time-series noise covariance matrix Ψt , distinct from the thermal noise covariance matrix Ψ0 , and compare its structure to Ψ0 and the signal coupling matrix SS(H) formed from the signal intensity vectors S. Inclusion of the measured time-series noise covariance matrix into the model relating tSNR and SNR0 improves the fit of experimental multichannel data and is shown to be distinct from Ψ0 or SS(H) . Time-series noise covariances in array coils are found to differ from Ψ0 and more surprisingly, from the signal coupling matrix SS(H) . Correct characterization of the time-series noise has implications for the analysis of time-series data and for improving the coil element combination process. Magn Reson Med 76:1708-1719, 2016. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  11. Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.

    Dixon, Andrew S; Miller, Geoffrey D; Bruno, Benjamin J; Constance, Jonathan E; Woessner, David W; Fidler, Trevor P; Robertson, James C; Cheatham, Thomas E; Lim, Carol S


    The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1, 2) The formation of Bcr-Abl oligomers is achieved through the coiled-coil domain at the N-terminus of Bcr.(3, 4) We have previously reported a modified version of this coiled-coil domain, CCmut2, which exhibits disruption of Bcr-Abl oligomeric complexes and results in decreased proliferation of CML cells and induction of apoptosis.(5) A major contributing factor to these enhanced capabilities is the destabilization of the CCmut2 homodimers, increasing the availability to interact with and inhibit Bcr-Abl. Here, we included an additional mutation (K39E) that could in turn further destabilize the mutant homodimer. Incorporation of this modification into CCmut2 (C38A, S41R, L45D, E48R, Q60E) generated what we termed CCmut3, and resulted in further improvements in the binding properties with the wild-type coiled-coil domain representative of Bcr-Abl [corrected]. A separate construct containing one revert mutation, CCmut4, did not demonstrate improved oligomeric properties and indicated the importance of the L45D mutation. CCmut3 demonstrated improved oligomerization via a two-hybrid assay as well as through colocalization studies, in addition to showing similar biologic activity as CCmut2. The improved binding between CCmut3 and the Bcr-Abl coiled-coil may be used to redirect Bcr-Abl to alternative subcellular locations with interesting therapeutic implications.

  12. Coiled-coil forming peptides for the induction of silver nanoparticles

    Božič Abram, Sabina [Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana (Slovenia); Graduate School of Biomedicine, University of Ljubljana, Ljubljana 1000 (Slovenia); Aupič, Jana [Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana (Slovenia); Doctoral Programme in Chemical Sciences, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana 1000 (Slovenia); Dražić, Goran [Laboratory for Materials Chemistry, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana (Slovenia); Gradišar, Helena [Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana (Slovenia); EN-FIST, Centre of Excellence, Trg Osvobodilne fronte 13, Ljubljana 1000 (Slovenia); Jerala, Roman, E-mail: [Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana (Slovenia); EN-FIST, Centre of Excellence, Trg Osvobodilne fronte 13, Ljubljana 1000 (Slovenia)


    Biopolymers with defined sequence patterns offer an attractive alternative for the formation of silver nanoparticle (AgNP). A set of coiled-coil dimer forming peptides was tested for their AgNP formation ability. Seventeen of those peptides mediated the formation of AgNPs in aqueous solution at neutral pH, while the formation of a coiled-coil dimer inhibited the nanoparticle generation. A QSAR regression model on the relationship between sequence and function suggests that in this peptide type the patterns KXQQ and KXEE are favorable, whereas Ala residues appear to have an inhibitory effect. UV–VIS spectra of the obtained nanoparticles gave a peak at around 420 nm, typical for AgNPs in the size range around 40 nm, which was confirmed by dynamic light scattering and transmission electron microscopy. Peptide-induced AgNPs exhibited good antibacterial activity, even after a 15 min contact time, while they had low toxicity to human cells at the same concentrations. These results show that our designed peptides generate AgNPs with antibacterial activity at mild conditions and might be used for antibacterial coatings. - Highlights: • 17 of the 30 tested coiled-coil forming peptides induce AgNP formation. • Coiled-coil dimer formation suppresses AgNP generation of individual peptides. • Size of the peptide-induced silver nanoparticles is around 40 nm. • QSAR analysis points to the importance of KXQQ and KXEE motifs for AgNP generation. • Peptide-induced silver nanoparticles exhibit antibacterial activity.

  13. Data-driven prediction and design of bZIP coiled-coil interactions.

    Potapov, Vladimir; Kaplan, Jenifer B; Keating, Amy E


    Selective dimerization of the basic-region leucine-zipper (bZIP) transcription factors presents a vivid example of how a high degree of interaction specificity can be achieved within a family of structurally similar proteins. The coiled-coil motif that mediates homo- or hetero-dimerization of the bZIP proteins has been intensively studied, and a variety of methods have been proposed to predict these interactions from sequence data. In this work, we used a large quantitative set of 4,549 bZIP coiled-coil interactions to develop a predictive model that exploits knowledge of structurally conserved residue-residue interactions in the coiled-coil motif. Our model, which expresses interaction energies as a sum of interpretable residue-pair and triplet terms, achieves a correlation with experimental binding free energies of R = 0.68 and significantly out-performs other scoring functions. To use our model in protein design applications, we devised a strategy in which synthetic peptides are built by assembling 7-residue native-protein heptad modules into new combinations. An integer linear program was used to find the optimal combination of heptads to bind selectively to a target human bZIP coiled coil, but not to target paralogs. Using this approach, we designed peptides to interact with the bZIP domains from human JUN, XBP1, ATF4 and ATF5. Testing more than 132 candidate protein complexes using a fluorescence resonance energy transfer assay confirmed the formation of tight and selective heterodimers between the designed peptides and their targets. This approach can be used to make inhibitors of native proteins, or to develop novel peptides for applications in synthetic biology or nanotechnology.

  14. 49 CFR 236.555 - Repaired or rewound receiver coil.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Repaired or rewound receiver coil. 236.555 Section 236.555 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... or rewound receiver coil. Receiver coil which has been repaired or rewound shall have the...

  15. The Roach muscle bundle and umbilical cord coiling

    de Laat, Monique W. M.; Nikkels, Peter G. J.; Franx, Arie; Visser, Gerard H. A.


    Objective: To determine if presence of the Roach muscle, a small muscle bundle tying just beside the umbilical artery, contributes to umbilical cord coiling. Methods: 251 umbilical cords were examined. The umbilical coiling index (UCI) was calculated as the number of coils divided by the cord length

  16. Transport of one SC coil through the village of Meyrin


    The energizing coils of the Synchro-cyclotron magnet were manufactured in Belgium before travelling to Basel in Switzerland by boat and continuing by road to Geneva. The first coil reached Geneva in December 1955, with the second following in early 1956. The coils were stored in a hangar at the Geneva airport before they were brought to CERN in May 1956.

  17. The training in epoxy-impregnated superconducting coils

    Fujita, H.; Bobrov, E.S.; Iwasa, Y.; Takaghi, T.; Tsukamoto, O.


    The authors have investigated the training of epoxy-impregnated superconducting coils. It has been observed that the boundary conditions at the coil ends have a crucial effect on shear-stress-induced epoxy cracks in the winding and consequently on the coil training. The results were quantified using acoustic emission data.

  18. Unconventional gradient coil designs in magnetic resonance imaging.

    Zhu, Minhua; Xia, Ling; Liu, Feng


    In magnetic resonance imaging (MRI), the gradient coils are used to encode the spatial positions of protons by varying the magnetic field linearly across the imaging subject. With the latest development of MRI technique and new clinical and research applications, the gradient coil system requires increasingly innovative designs. In this paper, four unconventional gradient coil designs are reviewed: (1) local gradient coils; (2) new coil configurations with reduced peripheral nerve stimulation (PNS); (3) dedicated structures designed for hybrid systems (combining MRI with other medical devices); and (4) the full 3D coil designs. For the first type, the development of local gradient coils (mainly head coils) is discussed chronologically and divided into three stages: the "golden" stage in the 1990s, the "wane" stage in the 2000s, and the "revival" stage in the 2010s. For the second type, various designs for the reduction of PNS problems have been described, including local and whole-body gradient coil systems. For the third design, a dedicated gradient coil design for multi-modality combination is illustrated with an MRI-LINAC system. Finally, gradient systems with non-layered coil structure are described in the fourth design type. We hope that this review on unconventional gradient coil designs will be useful for the new development of MRI technology and emerging medical applications.

  19. Needleless Electrospinning of Uniform Nanofibers Using Spiral Coil Spinnerets

    Xin Wang


    Full Text Available Polyvinyl alcohol nanofibers were prepared by a needleless electrospinning technique using a rotating spiral wire coil as spinneret. The influences of coil dimension (e.g., coil length, coil diameter, spiral distance, and wire diameter and operating parameters (e.g., applied voltage and spinning distance on electrospinning process, nanofiber diameter, and fiber productivity were examined. It was found that the coil dimension had a considerable influence on the nanofiber production rate, but minor effect on the fiber diameter. The fiber production rate increased with the increased coil length or coil diameter, or the reduced spiral distance or wire diameter. Higher applied voltage or shorter collecting distance also improved the fiber production rate but had little influence on the fiber diameter. Compared with the conventional needle electrospinning, the coil electrospinning produced finer fibers with a narrower diameter distribution. A finite element method was used to analyze the electric field on the coil surface and in electrospinning zone. It was revealed that the high electric field intensity was concentrated on the coil surface, and the intensity was highly dependent on the coil dimension, which can be used to explain the electrospinning performances of coils. In addition, PAN nanofibers were prepared using the same needleless electrospinning technique to verify the improvement in productivity.

  20. A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide.

    Hagelueken, Gregor; Clarke, Bradley R; Huang, Hexian; Tuukkanen, Anne; Danciu, Iulia; Svergun, Dmitri I; Hussain, Rohanah; Liu, Huanting; Whitfield, Chris; Naismith, James H


    Long-chain bacterial polysaccharides have important roles in pathogenicity. In Escherichia coli O9a, a model for ABC transporter-dependent polysaccharide assembly, a large extracellular carbohydrate with a narrow size distribution is polymerized from monosaccharides by a complex of two proteins, WbdA (polymerase) and WbdD (terminating protein). Combining crystallography and small-angle X-ray scattering, we found that the C-terminal domain of WbdD contains an extended coiled-coil that physically separates WbdA from the catalytic domain of WbdD. The effects of insertions and deletions in the coiled-coil region were analyzed in vivo, revealing that polymer size is controlled by varying the length of the coiled-coil domain. Thus, the coiled-coil domain of WbdD functions as a molecular ruler that, along with WbdA:WbdD stoichiometry, controls the chain length of a model bacterial polysaccharide.

  1. Tailored Presentation of Carbohydrates on a Coiled Coil-Based Scaffold for Asialoglycoprotein Receptor Targeting.

    Zacco, Elsa; Hütter, Julia; Heier, Jason L; Mortier, Jérémie; Seeberger, Peter H; Lepenies, Bernd; Koksch, Beate


    The coiled-coil folding motif represents an ideal scaffold for the defined presentation of ligands due to the possibility of positioning them at specific distances along the axis. We created a coiled-coil glycopeptide library to characterize the distances between the carbohydrate-binding sites of the asialoglycoprotein receptors (ASGPR) on hepatocytes. The components of the glycopeptide library vary for the number of displayed ligands (galactose), their position on the peptide sequence, and the space between peptide backbone and carbohydrate. We determined the binding of the glycopeptides to the hepatocytes, and we established the optimal distance and orientation of the galactose moieties for interaction with the ASGPR using flow cytometry. We confirmed that the binding occurs through endocytosis mediated by ASGPR via inhibition studies with cytochalasin D; fluorescence microscopy studies display the uptake of the carrier peptides inside the cell. Thus, this study demonstrates that the coiled-coil motif can be used as reliable scaffold for the rational presentation of ligands.

  2. CENP-K and CENP-H may form coiled-coils in the kinetochores

    QIU ShuLan; WANG JiaNing; YU Chuang; HE DaCheng


    Kinetochores are large proteinaceous structure on the surface of chromosomes' primary constriction during mitosis. They link chromosomes to spindle microtubules and also regulate the spindle assem-bly checkpoint, which is crucial for correct chromosome segregation in all eukaryotes. The better known core networks of kinetochores include the KMN network (K, KNL1; M, Mis12 complex; N, Ndc80 complex)and CCAN (constitutive centromere-associated network). However, the detailed molecular mechanism of the kinetochore protein network remains unclear. This study demonstrates that CENP-H and CENP-K form quite stable subcomplex by TAP (tandem affinity purification) with HEK 293 cells which express TAP-CENP-K, with the ratio of purified CENP-H and CENP-K being close to 1 : 1 even with high salt. Bioinformatic analysis suggests that CENP-H and CENP-K are enriched with coiled-coil regions. This implies that CENP-H and CENP-K form heterodimeric coiled-coils. Furthermore, the func-tional regions which form the complex are respectively located on their N- and C-terminals, but the association between the C-terminals is more complex. It is possible that this is the first identified het-erodimeric coiled-coils within the inner kinetochore, which is directly involved in the attachment be-tween kinetochores and the spindle microtubules.

  3. Coiled-Coil Proteins Facilitated the Functional Expansion of the Centrosome

    Kuhn, Michael; Hyman, Anthony A.; Beyer, Andreas


    Repurposing existing proteins for new cellular functions is recognized as a main mechanism of evolutionary innovation, but its role in organelle evolution is unclear. Here, we explore the mechanisms that led to the evolution of the centrosome, an ancestral eukaryotic organelle that expanded its functional repertoire through the course of evolution. We developed a refined sequence alignment technique that is more sensitive to coiled coil proteins, which are abundant in the centrosome. For proteins with high coiled-coil content, our algorithm identified 17% more reciprocal best hits than BLAST. Analyzing 108 eukaryotic genomes, we traced the evolutionary history of centrosome proteins. In order to assess how these proteins formed the centrosome and adopted new functions, we computationally emulated evolution by iteratively removing the most recently evolved proteins from the centrosomal protein interaction network. Coiled-coil proteins that first appeared in the animal–fungi ancestor act as scaffolds and recruit ancestral eukaryotic proteins such as kinases and phosphatases to the centrosome. This process created a signaling hub that is crucial for multicellular development. Our results demonstrate how ancient proteins can be co-opted to different cellular localizations, thereby becoming involved in novel functions. PMID:24901223

  4. CENP-K and CENP-H may form coiled-coils in the kinetochores


    Kinetochores are large proteinaceous structure on the surface of chromosomes’ primary constriction during mitosis. They link chromosomes to spindle microtubules and also regulate the spindle assem- bly checkpoint, which is crucial for correct chromosome segregation in all eukaryotes. The better known core networks of kinetochores include the KMN network (K, KNL1; M, Mis12 complex; N, Ndc80 complex)and CCAN (constitutive centromere-associated network). However, the detailed molecular mechanism of the kinetochore protein network remains unclear. This study demonstrates that CENP-H and CENP-K form quite stable subcomplex by TAP (tandem affinity purification) with HEK 293 cells which express TAP-CENP-K, with the ratio of purified CENP-H and CENP-K being close to 1︰1 even with high salt. Bioinformatic analysis suggests that CENP-H and CENP-K are enriched with coiled-coil regions. This implies that CENP-H and CENP-K form heterodimeric coiled-coils. Furthermore, the func- tional regions which form the complex are respectively located on their N- and C-terminals, but the association between the C-terminals is more complex. It is possible that this is the first identified het- erodimeric coiled-coils within the inner kinetochore, which is directly involved in the attachment be- tween kinetochores and the spindle microtubules.

  5. Electromechanical design and construction of a rotating radio-frequency coil system for applications in magnetic resonance.

    Trakic, Adnan; Weber, Ewald; Li, Bing Keong; Wang, Hua; Liu, Feng; Engstrom, Craig; Crozier, Stuart


    While recent studies have shown that rotating a single radio-frequency (RF) coil during the acquisition of magnetic resonance (MR) images provides a number of hardware advantages (i.e., requires only one RF channel, avoids coil-coil coupling and facilitates large-scale multinuclear imaging), they did not describe in detail how to build a rotating RF coil system. This paper presents detailed engineering information on the electromechanical design and construction of a MR-compatible RRFC system for human head imaging at 2 T. A custom-made (bladeless) pneumatic Tesla turbine was used to rotate the RF coil at a constant velocity, while an infrared optical encoder measured the selected frequency of rotation. Once the rotating structure was mechanically balanced and the compressed air supply suitably regulated, the maximum frequency of rotation measured ~14.5 Hz with a 2.4% frequency variation over time. MR images of a water phantom and human head were obtained using the rotating RF head coil system.

  6. Solutions for Safe Hot Coil Evacuation and Coil Handling in Case of Thick and High Strength Steel

    Sieberer Stefan; Pichler Lukas; Hackl Manfred


    Currently hot rolling plants are entering the market segment for thick gauges and high strength steel grades where the elastic bending property of the strip leads to internal forces in the coil during coiling operation. The strip tends to open. Primetals is investigating several possibilities to facilitate safe coil evacuation and coil handling under spring-back conditions. The contribution includes finite element models of such mechanical solutions. Results of parameter variation and stabili...

  7. Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm.

    Otani, Tomohiro; Ii, Satoshi; Shigematsu, Tomoyoshi; Fujinaka, Toshiyuki; Hirata, Masayuki; Ozaki, Tomohiko; Wada, Shigeo


    Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20-25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization.

  8. Study on the performance improvement of the high temperature superconducting coil with several separated coils at the edges

    Ishiguri, S.; Oka, T.; Fukui, S.; Ogawa, J.; Sato, T.


    In designing high temperature superconducting (HTS) coils, it is important to secure large magnetic fields and stored energy using shorter tape length. Thus, it is necessary to improve the transport current performance of the coils. The critical current and n-value of an HTS tape depend on magnetic fields and flux angles under constant temperature. Considering these dependencies, we established a model to analyze coil critical current. This model clarifies that relatively large electric fields are generated at the coil edges. This adversely affects the transport current performance. In this study, the coil edge is separated into several coils, keeping the total tape length constant. This increases the coil critical current, stored energy, central magnetic field, and also the coil volume, which contains vacancies created by the separation. To estimate coil performance, we calculated the stored energy density, whose denominator is the increased coil volume. This stored energy density reaches its maximum value when the number of the separated coils is eight. At this optimum separation, the central magnetic field increases by 13%, and the stored energy improves by 43%, compared to a rectangular coil wound with the same tape length.

  9. Structural attributes for the recognition of weak and anomalous regions in coiled-coils of myosins and other motor proteins

    Sunitha Margaret S


    Full Text Available Abstract Background Coiled-coils are found in different proteins like transcription factors, myosin tail domain, tropomyosin, leucine zippers and kinesins. Analysis of various structures containing coiled-coils has revealed the importance of electrostatic and hydrophobic interactions. In such domains, regions of different strength of interactions need to be identified since they could be biologically relevant. Findings We have updated our coiled-coil validation webserver, now called COILCHECK+, where new features were added to efficiently identify the strength of interaction at the interface region and measure the density of charged residues and hydrophobic residues. We have examined charged residues and hydrophobic ladders, using a new algorithm called CHAHO, which is incorporated within COILCHECK + server. CHAHO permits the identification of spatial charged residue patches and the continuity of hydrophobic ladder which stabilizes and destabilizes the coiled-coil structure. Conclusions The availability of such computational tools should be useful to understand the importance of spatial clustering of charged residues and the continuity of hydrophobic residues at the interface region of coiled-coil dimers. COILCHECK + is a structure based tool to validate coiled-coil stability; it can be accessed at

  10. Subunit b-dimer of the Escherichia coli ATP synthase can form left-handed coiled-coils.

    Wise, John G; Vogel, Pia D


    One remaining challenge to our understanding of the ATP synthase concerns the dimeric coiled-coil stator subunit b of bacterial synthases. The subunit b-dimer has been implicated in important protein interactions that appear necessary for energy conservation and that may be instrumental in energy conservation during rotary catalysis by the synthase. Understanding the stator structure and its interactions with the rest of the enzyme is crucial to the understanding of the overall catalytic mechanism. Controversy exists on whether subunit b adopts a classic left-handed or a presumed right-handed dimeric coiled-coil and whether or not staggered pairing between nonhomologous residues in the homodimer is required for intersubunit packing. In this study we generated molecular models of the Escherichia coli subunit b-dimer that were based on the well-established heptad-repeat packing exhibited by left-handed, dimeric coiled-coils by employing simulated annealing protocols with structural restraints collected from known structures. In addition, we attempted to create hypothetical right-handed coiled-coil models and left- and right-handed models with staggered packing in the coiled-coil domains. Our analyses suggest that the available structural and biochemical evidence for subunit b can be accommodated by classic left-handed, dimeric coiled-coil quaternary structures.

  11. Planar quadrature coil design using shielded-loop resonators

    Stensgaard, A


    The shielded-loop resonator is known to have a low capacitive sample loss due to a perfect balancing. In this paper, it is demonstrated that shielded-loop technology also can be used to improve design of planar quadrature coils. Both a dual-loop circuit and especially a dual-mode circuit may...... benefit from use of shielded-loop resonators. Observations in measurements agree with theory for both a dual-loop coil and a dual-mode coil. The coils were designed for use as transmit/receive coil for 1H imaging and spectroscopy at 4.7 T in rat brain....

  12. Application of Microstructure Engineering in Steel Coil Cooling Process

    LIU Zheng-dong; D Q Jin; I V Samarasekera; J K Brimacombe


    The coil cooling and its role in a hot strip mill were reviewed.A mathematical model was developed to describe and analyze the thermal history and its impact on precipitation phenomena during coil cooling for plain car bon,HSLA-V and HSLA-Nb steels.The predicted result of the thermal model was compared with that measured from industrial coil.The effect of cooling condition and coil dimension on the thermal history and final mechanical properties of the steel strip was examined.The coiling temperature and cooling rate have crucial influence on the precipitation strengthening.

  13. Mechanical characteristics of the ATLAS B0 model coil

    Foussat, A; Dudarev, A; Mayri, C; Miele, P; Sun, Z; ten Kate, H H J; Volpini, G


    The ATLAS B0 model coil has been tested at CERN to verify the design parameters of the Barrel Toroid coils (BT). The mechanical behavior of the B0 superconducting coil and its support structure is reported and compared with coil design calculations. The mechanical stresses and structural force levels during cooling down and excitation phases were monitored using strain gauges, position sensors and capacitive force transducers instrumentation. In the ATLAS magnet test facility, a magnetic mirror is used to reproduce the electromagnetic forces present in the BT coils, once these are assembled in toroid in the underground cavern in 2004. (8 refs).

  14. SSC (Superconducting Super Collider) dipole coil production tooling

    Carson, J.A.; Barczak, E.J.; Bossert, R.C.; Brandt, J.S.; Smith, G.A.


    Superconducting Super Collider dipole coils must be produced to high precision to ensure uniform prestress and even conductor distribution within the collared coil assembly. Tooling is being prepared at Fermilab for the production of high precision 1M and 16.6M SSC dipole coils suitable for mass production. The design and construction methods builds on the Tevatron tooling and production experience. Details of the design and construction methods and measured coil uniformity of 1M coils will be presented. 4 refs., 10 figs.

  15. Random coil chemical shift for intrinsically disordered proteins

    Kjærgaard, Magnus; Brander, Søren; Poulsen, Flemming Martin


    . Temperature has a non-negligible effect on the (13)C random coil chemical shifts, so temperature coefficients are reported for the random coil chemical shifts to allow extrapolation to other temperatures. The pH dependence of the histidine random coil chemical shifts is investigated in a titration series......, which allows the accurate random coil chemical shifts to be obtained at any pH. By correcting the random coil chemical shifts for the effects of temperature and pH, systematic biases of the secondary chemical shifts are minimized, which will improve the reliability of detection of transient secondary...

  16. Spontaneous quenches of a high temperature superconducting pancake coil

    Lue, J.W.; Lubell, M.S. [Oak Ridge National Lab., TN (United States); Aized, D.; Campbell, J.M.; Schwall, R.E. [American Superconductor Corp., Westborough, MA (United States)


    A double-pancake coil made of Bi-2223/Ag high temperature superconducting (HTS) tape was constructed with an embedded heater and graded conductors to study the stability and quench propagation in HTS coils. The experiments were performed with liquid nitrogen and gaseous helium cooling in temperatures ranging from 5 to 77 K. The coil was very stable, and no ``normal`` zone was sustained or propagated with local pulsed heating. However, spontaneous quenches of the cod were experienced. This was found to be the result of having the coil current higher than that of the lower I{sub c} sections of the coil for a long time. This quench process took minutes to develop--much longer than would be expected in a low temperature superconducting coil. The quench behaved more like a spreading and continuous heating of an increasingly larger partially resistive section of the coil than like a sequential ``normal`` front propagation.

  17. Fabrication of the superconducting coils for Wendelstein 7-X

    Risse, Konrad E-mail:; Rummel, Th.; Wegener, L.; Holzthuem, R.; Jaksic, N.; Kerl, F.; Sapper, J


    The Max Planck Institute of Plasma Physics is building up the stellarator fusion experiment Wendelstein 7-X (W7-X) at the branch institute in Greifswald. W7-X continues the line of stellarator experiments at IPP. To allow for steady state operation W7-X has a superconducting coil system with 50 non-planar and 20 planar coils. The coil system is grouped in five equal modules, each consisting of two mirror symmetric half modules. The half modules are assembled from five different non-planar coils, two planar coils and a sector of the coil support structure. All cryogenic parts are enclosed in a cryostat to protect them from ambient temperature. The magnet system was ordered from the European industry. The production of superconductor, winding packs and encasings are under way. The main focus of this contribution aims on the fabrication state of the coil system.

  18. Output beam analysis of high power COIL

    Deli Yu(于德利); Fengting Sang(桑凤亭); Yuqi Jin(金玉奇); Yizhu Sun(孙以珠)


    As the output power of a chemical oxygen iodine laser (COIL) increases, the output laser beam instabilityappears as the far-field beam spot drift and deformation for the large Fresnel number unstable resonator.In order to interpret this phenomenon, an output beam mode simulation code was developed with the fastFourier transform method. The calculation results show that the presence of the nonuniform gain in COILproduces a skewed output intensity distribution, which causes the mirror tilt and bulge due to the thermalexpansion. With the output power of COIL increases, the mirror surfaces, especially the back surface ofthe scraper mirror, absorb more and more heat, which causes the drift and deformation of far field beamspot seriously. The initial misalignment direction is an important factor for the far field beam spot driftingand deformation.

  19. Theory of the quadrature elliptic birdcage coil.

    Leifer, M C


    This paper presents the theory of the quadrature birdcage coil wound on an elliptic cylindrical former. A conformal transformation of the ellipse to a circular geometry is used to derive the optimal sampling of the continuous surface current distribution to produce uniform magnetic fields within an elliptic cylinder. The analysis is rigorous for ellipses of any aspect ratio and shows how to produce quadrature operation of the elliptic birdcage with a conventional hybrid combiner. Insight gained from the transformation is also used to analyze field homogeneity, find the optimal RF shield shape, and specify component values to produce the correct current distribution in practice. Measurements and images from a 16-leg elliptic birdcage coil at both low and high frequencies show good quadrature performance, homogeneity, and sensitivity.

  20. Magnetically Damped Furnace Bitter Magnet Coil 1

    Bird, M. D.


    A magnet has been built by the National High Magnetic Field Laboratory for NASA on a cost reimbursement contract. The magnet is intended to demonstrate the technology and feasibility of building a magnet for space based crystal growth. A Bitter magnet (named after Francis Bitter, its inventor) was built consisting of four split coils electrically in series and hydraulically in parallel. The coils are housed in a steel vessel to reduce the fringe field and provide some on-axis field enhancement. The steel was nickel plated and Teflon coated to minimize interaction with the water cooling system. The magnet provides 0.14 T in a 184 mm bore with 3 kW of power.

  1. Acute lung injury following refrigeration coil deicing.

    McKeown, Nathanael J; Burton, Brent T


    We report a case of a worker who developed ALI requiring mechanical ventilatory support after attempting to melt ice condensate by applying the flame of an oxy-acetylene torch to refrigeration coils charged with a halocarbon refrigerant in a closed environment. A discussion of possible etiologies are discussed, including phosgene, carbonyl fluoride, and nitrogen oxides. Primary prevention with adequate respiratory protection is recommended whenever deicing is performed in a closed space environment.

  2. Mechanical Resonances of Helically Coiled Carbon Nanowires

    Saini, D.; Behlow, H.; Podila, R.; Dickel, D.; Pillai, B.; Skove, M. J.; Serkiz, S. M.; Rao, A. M.


    Despite their wide spread applications, the mechanical behavior of helically coiled structures has evaded an accurate understanding at any length scale (nano to macro) mainly due to their geometrical complexity. The advent of helically coiled micro/nanoscale structures in nano-robotics, nano-inductors, and impact protection coatings has necessitated the development of new methodologies for determining their shear and tensile properties. Accordingly, we developed a synergistic protocol which (i) integrates analytical, numerical (i.e., finite element using COMSOL®) and experimental (harmonic detection of resonance; HDR) methods to obtain an empirically validated closed form expression for the shear modulus and resonance frequency of a singly clamped helically coiled carbon nanowire (HCNW), and (ii) circumvents the need for solving 12th order differential equations. From the experimental standpoint, a visual detection of resonances (using in situ scanning electron microscopy) combined with HDR revealed intriguing non-planar resonance modes at much lower driving forces relative to those needed for linear carbon nanotube cantilevers. Interestingly, despite the presence of mechanical and geometrical nonlinearities in the HCNW resonance behavior the ratio of the first two transverse modes f2/f1 was found to be similar to the ratio predicted by the Euler-Bernoulli theorem for linear cantilevers.

  3. Numerical dosimetry of transcranial magnetic stimulation coils

    Crowther, Lawrence; Hadimani, Ravi; Jiles, David


    Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique capable of stimulating neurons by means of electromagnetic induction. TMS can be used to map brain function and shows promise for the diagnosis and treatment of neurological and psychiatric disorders. Calculation of fields induced in the brain are necessary to accurately identify stimulated neural tissue during TMS. This allows the development of novel TMS coil designs capable of stimulating deeper brain regions and increasing the localization of stimulation that can be achieved. We have performed numerical calculations of magnetic and electric field with high-resolution anatomically realistic human head models to find these stimulated brain regions for a variety of proposed TMS coil designs. The realistic head models contain heterogeneous tissue structures and electrical conductivities, yielding superior results to those obtained from the simplified homogeneous head models that are commonly employed. The attenuation of electric field as a function of depth in the brain and the localization of stimulating field have been methodically investigated. In addition to providing a quantitative comparison of different TMS coil designs the variation of induced field between subjects has been investigated. We also show the differences in induced fields between adult, adolescent and child head models to preemptively identify potential safety issues in the application of pediatric TMS.

  4. The coiling of electrified liquid jets

    Rivero Rodriguez, Javier; Pérez-Saborid, Miguel


    We have carried out a numerical study of the coiling regime which takes place when an electrified liquid jet issuing from an orifice drilled in a metal plate electrode reaches the counter electrode. Based on the slenderness assumption, we have derived the set of one-dimensional dynamical equations by averaging the underlying balance laws over the jet cross sections (Cosserat rod model). Therefore, our equations and boundary conditions are related to those obtained by N.M. Ribe (Ann. Rev Fluid Mech., 2012) for the coiling of liquid ropes, but including electrostatic effects. In a first approach, we have simplified the electrical terms entering the problem by assuming a constant external electric field between electrodes, and that the charges are convected by the jet surface interacting electrostatically with each other via the local interaction approximation (Yarin et al., 2001). We have numerically investigated the problem in order to analize how the coiling regime depends on the dimensionless parameters of the problem, i.e., the Reynolds number, the electrical Bond number and the capillary number. In particular, we have found that both the displacement of the centerline of the jet and its cross-sectional stretching greatly depend on the electrostatic effects. Thanks to the MINECO (Spain) for partial support under grant DPI2010-20450-C03-02.

  5. Finite Element Analyses and Instrumentation Layout for Single Coil Testing of TF Coils in HT-7U

    陈文革; 翁佩德


    The HT-7U tokamak is a magnetically-confined full superconducting fusion device,consisting of superconducting toroidal field (TF) coils and superconducting poloidal field (PF)coils. These coils are wound with cable-in-conductor (CICC) which is based on UNK NbTi wiresmade in Russian [1]. A single D-shaped toroidal field magnet coil will be tested for large andexpensive magnets systems before assembling them in the toroidal configuration. This paperdescribes the layout of the instrumentation for a superconducting test facility based on the resultsof a finite element modeling of the single coil of toroidal magnetic field (TF) coils in HT-7Utokamak device. At the same time, the design of coil support structure in the test facility isparticularly discussed in some detail.

  6. Interfase y software de control para operar en sincronismo un automuestreador y un atomizador electrotérmico por filamento de tungsteno en espectrofotometría de absorción atómica Development of interface and software for synchronous operation of an autosampler and a tungsten coil electrothermal atomizer coupled to an atomic absorption spectophotometer

    J. Neira


    Full Text Available The interface and software for synchronous control of an autosampler and an electrothermal tungsten coil atomizer in atomic absorption spectrophotometry were developed. The control of the power supply, the trigger of the Read function of the spectrophotometer and the automatic operation of the autosampler was performed by software written in "TurboBasic". The system was evaluated by comparison of the repeatability of peak-height absorbances obtained in the atomization of lead by consecutive 10-µl injections of solutions (prepared in 0.2% v/v HNO3 using autosampler and manual sample introduction, and also by long term operation.

  7. Short echo time proton spectroscopy of the brain in healthy volunteers using an insert gradient head coil

    Gideon, P; Danielsen, E R; Schneider, M;


    An insert gradient head coil with built-in X, Y, and Z gradients was used for localized proton spectroscopy in the brain of healthy volunteers, using short echo time stimulated echo acquisition mode (STEAM) sequences. Volume of interest size was 3.4 ml, repetition time was 6.0 s, and echo times...... were 10 and 20 ms, respectively. Good quality proton spectra with practically no eddy current artefacts were acquired allowing observation of strongly coupled compounds, and compounds with short T2 relaxation times. The gradient head coil thus permits further studies of compounds such as glutamine...

  8. Design of Electromagnetic Moving-coil type Voice Coil Motor for Scanning mirror of Barcode reader

    Shin, Bu Hyun; Lee, Jeong Woo; Shim, Hyun Ho; Park, Sang Goo [Hanbat National Univ., Daejeon (Korea, Republic of); Lee, Seung Yop [Sogang Univ., Seoul (Korea, Republic of)


    A voice coil actuator with moving coil type for scanning mirror system of barcode reader has been developed. The actuator has a simple structure including a magnet, a coil and a pin. The performance of the actuator is analyzed by a linearized theoretical model. And the dynamic performance of the proposed actuator is predicted through motor constant and restoring constant obtained by finite element simulations. The theoretical model was verified by the prototype which has 64 Hz resonance frequency and 60 deg reflecting angle. We also discovered that that 3 V input can make the actuator rotate over 61.8 deg reflecting angle at 50 Hz resonance frequency. The proposed actuator can simplify its driving configuration because of its implementation of open-loop control.

  9. Transcranial Magnetic Stimulation-coil design with improved focality

    Rastogi, P.; Lee, E. G.; Hadimani, R. L.; Jiles, D. C.


    Transcranial Magnetic Stimulation (TMS) is a technique for neuromodulation that can be used as a non-invasive therapy for various neurological disorders. In TMS, a time varying magnetic field generated from an electromagnetic coil placed on the scalp is used to induce an electric field inside the brain. TMS coil geometry plays an important role in determining the focality and depth of penetration of the induced electric field responsible for stimulation. Clinicians and basic scientists are interested in stimulating a localized area of the brain, while minimizing the stimulation of surrounding neural networks. In this paper, a novel coil has been proposed, namely Quadruple Butterfly Coil (QBC) with an improved focality over the commercial Figure-8 coil. Finite element simulations were conducted with both the QBC and the conventional Figure-8 coil. The two coil's stimulation profiles were assessed with 50 anatomically realistic MRI derived head models. The coils were positioned on the vertex and the scalp over the dorsolateral prefrontal cortex to stimulate the brain. Computer modeling of the coils has been done to determine the parameters of interest-volume of stimulation, maximum electric field, location of maximum electric field and area of stimulation across all 50 head models for both coils.

  10. Retrieval of prolapsed coils during endovascular treatment of cerebral aneurysms

    Dinc, Hasan [Karadeniz Technical University, Department of Radiology, Faculty of Medicine, Trabzon (Turkey); KTU Farabi Hospital, Department of Radiology, Trabzon (Turkey); Kuzeyli, Kayhan [Karadeniz Technical University, Department of Neurosurgery, Faculty of Medicine, Trabzon (Turkey); Kosucu, Polat; Sari, Ahmet [Karadeniz Technical University, Department of Radiology, Faculty of Medicine, Trabzon (Turkey); Cekirge, Saruhan [Hacettepe University, Department of Radiology, Faculty of Medicine, Ankara (Turkey)


    One of the feared complications during detachable coil embolization of cerebral aneurysms is herniation of a coil loop into the parent artery. Although coil protrusion of one or two loops into the parent vessel may not cause adverse events and in some instances can be ignored, the authors believe that coil retrieval is indicated if a free end is seen pulsating along the blood flow stream to prevent migration of the entire coil mass. In one patient, a microballoon was inflated across the neck of the aneurysm during retrieval of a herniated coil to prevent further coil herniation from the aneurysm sac. We present two cases in which prolapsed coils were successfully retrieved either using a microsnare and balloon combination or a microsnare alone. This report focuses on the efficacy of the Amplatz microsnare for such retrievals and the circumstances in which a herniated coil needs to be retrieved. We report two cases in which embolization coils partially migrated into the parent artery during endovascular treatment of cerebral aneurysm and were retrieved using the Amplatz Nitinol microsnare. (orig.)

  11. The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype.

    Patricia Santos-Valle

    Full Text Available Laminins are large heterotrimeric cross-shaped extracellular matrix glycoproteins with terminal globular domains and a coiled-coil region through which the three chains are assembled and covalently linked. Laminins are key components of basement membranes, and they serve as attachment sites for cell adhesion, migration and proliferation. In this work, we produced a recombinant fragment comprising the entire laminin coiled-coil of the α1-, β1-, and γ1-chains that assemble into a stable heterotrimeric coiled-coil structure independently of the rest of the molecule. This domain was biologically active and not only failed to serve as a substrate for cell attachment, spreading and focal adhesion formation but also inhibited cell adhesion to laminin when added to cells in a soluble form at the time of seeding. Furthermore, gene array expression profiling in cells cultured in the presence of the laminin coiled-coil domain revealed up-regulation of genes involved in cell motility and invasion. These findings were confirmed by real-time quantitative PCR and zymography assays. In conclusion, this study shows for the first time that the laminin coiled-coil domain displays anti-adhesive functions and has potential implications for cell migration during matrix remodeling.

  12. Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein

    Lander Angelika


    Full Text Available Abstract The nucleoprotein (NP of Marburg virus (MARV is responsible for the encapsidation of viral genomic RNA and the formation of the helical nucleocapsid precursors that accumulate in intracellular inclusions in infected cells. To form the large helical MARV nucleocapsid, NP needs to interact with itself and the viral proteins VP30, VP35 and L, which are also part of the MARV nucleocapsid. In the present study, a conserved coiled coil motif in the central part of MARV NP was shown to be an important element for the interactions of NP with itself and VP35, the viral polymerase cofactor. Additionally, the coiled coil motif was essential for the formation of NP-induced intracellular inclusions and for the function of NP in the process of transcription and replication of viral RNA in a minigenome system. Transfer of the coiled coil motif to a reporter protein was sufficient to mediate interaction of the constructed fusion protein with the N-terminus of NP. The coiled coil motif is bipartite, constituted by two coiled coils which are separated by a flexible linker.

  13. The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype.

    Santos-Valle, Patricia; Guijarro-Muñoz, Irene; Cuesta, Angel M; Alonso-Camino, Vanesa; Villate, Maider; Alvarez-Cienfuegos, Ana; Blanco, Francisco J; Sanz, Laura; Alvarez-Vallina, Luis


    Laminins are large heterotrimeric cross-shaped extracellular matrix glycoproteins with terminal globular domains and a coiled-coil region through which the three chains are assembled and covalently linked. Laminins are key components of basement membranes, and they serve as attachment sites for cell adhesion, migration and proliferation. In this work, we produced a recombinant fragment comprising the entire laminin coiled-coil of the α1-, β1-, and γ1-chains that assemble into a stable heterotrimeric coiled-coil structure independently of the rest of the molecule. This domain was biologically active and not only failed to serve as a substrate for cell attachment, spreading and focal adhesion formation but also inhibited cell adhesion to laminin when added to cells in a soluble form at the time of seeding. Furthermore, gene array expression profiling in cells cultured in the presence of the laminin coiled-coil domain revealed up-regulation of genes involved in cell motility and invasion. These findings were confirmed by real-time quantitative PCR and zymography assays. In conclusion, this study shows for the first time that the laminin coiled-coil domain displays anti-adhesive functions and has potential implications for cell migration during matrix remodeling.

  14. High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice

    Berg, S.A.A. van den; Nabben, M.; Bijland, S.; Voshol, P.J.; Klinken, J.B. van; Havekes, L.M.; Romijn, J.A.; Hoeks, J.; Hesselink, M.K.; Schrauwen, P.; Dijk, K.W. van


    Considerable variation in energy expenditure is observed in C57Bl/6 mice on a high-fat diet. Because muscle tissue is a major determinant of whole-body energy expenditure, we set out to determine the variation in energy expenditure and its possible association with skeletal muscle mitochondrial func

  15. Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.

    Vidal, Berta; Ardite, Esther; Suelves, Mònica; Ruiz-Bonilla, Vanessa; Janué, Anna; Flick, Matthew J; Degen, Jay L; Serrano, Antonio L; Muñoz-Cánoves, Pura


    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate inflammatory changes and faulty tissue reorganization remain poorly defined. Here, we show that fibrin deposition is a conspicuous consequence of muscle-vascular damage in dystrophic muscles of DMD patients and mdx mice and that elimination of fibrin(ogen) attenuated dystrophy progression in mdx mice. These benefits appear to be tied to: (i) a decrease in leukocyte integrin α(M)β(2)-mediated proinflammatory programs, thereby attenuating counterproductive inflammation and muscle degeneration; and (ii) a release of satellite cells from persistent inhibitory signals, thereby promoting regeneration. Remarkably, Fib-gamma(390-396A) (Fibγ(390-396A)) mice expressing a mutant form of fibrinogen with normal clotting function, but lacking the α(M)β(2) binding motif, ameliorated dystrophic pathology. Delivery of a fibrinogen/α(M)β(2) blocking peptide was similarly beneficial. Conversely, intramuscular fibrinogen delivery sufficed to induce inflammation and degeneration in fibrinogen-null mice. Thus, local fibrin(ogen) deposition drives dystrophic muscle inflammation and dysfunction, and disruption of fibrin(ogen)-α(M)β(2) interactions may provide a novel strategy for DMD treatment.

  16. Effect of Inductive Coil Geometry on the Thrust Efficiency of a Microwave Assisted Discharge Inductive Plasma Accelerator

    Hallock, Ashley; Polzin, Kurt; Emsellem, Gregory


    Pulsed inductive plasma thrusters [1-3] are spacecraft propulsion devices in which electrical energy is capacitively stored and then discharged through an inductive coil. The thruster is electrodeless, with a time-varying current in the coil interacting with a plasma covering the face of the coil to induce a plasma current. Propellant is accelerated and expelled at a high exhaust velocity (O(10-100 km/s)) by the Lorentz body force arising from the interaction of the magnetic field and the induced plasma current. While this class of thruster mitigates the life-limiting issues associated with electrode erosion, pulsed inductive plasma thrusters require high pulse energies to inductively ionize propellant. The Microwave Assisted Discharge Inductive Plasma Accelerator (MAD-IPA) [4, 5] is a pulsed inductive plasma thruster that addressees this issue by partially ionizing propellant inside a conical inductive coil via an electron cyclotron resonance (ECR) discharge. The ECR plasma is produced using microwaves and permanent magnets that are arranged to create a thin resonance region along the inner surface of the coil, restricting plasma formation, and in turn current sheet formation, to a region where the magnetic coupling between the plasma and the inductive coil is high. The use of a conical theta-pinch coil is under investigation. The conical geometry serves to provide neutral propellant containment and plasma plume focusing that is improved relative to the more common planar geometry of the Pulsed Inductive Thruster (PIT) [2, 3], however a conical coil imparts a direct radial acceleration of the current sheet that serves to rapidly decouple the propellant from the coil, limiting the direct axial electromagnetic acceleration in favor of an indirect acceleration mechanism that requires significant heating of the propellant within the volume bounded by the current sheet. In this paper, we describe thrust stand measurements performed to characterize the performance

  17. Retrieval of unintended migrated detached coil: case report.

    Oh, Jiwoong; Kim, Jongyun; Hong, Sunki; Hu, Chul; Pyen, Jinsu; Whang, Kum; Cho, Sungmin; You, Do-Sung


    Owing to the rapid development of intervention techniques and devices, endovascular coil embolization of cerebral arteries has become standardized. It is particularly preferred when a patient presents with an unruptured intracranial aneurysm of the posterior communicating artery (PcomA). However, the risk of thrombogenic complications of the coil migration may also result in a large cerebral infarction. When coil migration occurs during embolization, a procedure for removal of the embolic coil should be performed immediately. We experienced a clinically rare case of migration of a framing coil to the distal middle cerebral artery aneurysm during endovascular embolization of an unruptured PcomA aneurysm. The migrated coil was barely retrieved using snare techniques.

  18. Toroid cavity/coil NMR multi-detector

    Gerald, II, Rex E.; Meadows, Alexander D.; Gregar, Joseph S.; Rathke, Jerome W.


    An analytical device for rapid, non-invasive nuclear magnetic resonance (NMR) spectroscopy of multiple samples using a single spectrometer is provided. A modified toroid cavity/coil detector (TCD), and methods for conducting the simultaneous acquisition of NMR data for multiple samples including a protocol for testing NMR multi-detectors are provided. One embodiment includes a plurality of LC resonant circuits including spatially separated toroid coil inductors, each toroid coil inductor enveloping its corresponding sample volume, and tuned to resonate at a predefined frequency using a variable capacitor. The toroid coil is formed into a loop, where both ends of the toroid coil are brought into coincidence. Another embodiment includes multiple micro Helmholtz coils arranged on a circular perimeter concentric with a central conductor of the toroid cavity.

  19. Ferrite core non-linearity in coils for magnetic neurostimulation.

    RamRakhyani, Anil Kumar; Lazzi, Gianluca


    The need to correctly predict the voltage across terminals of mm-sized coils, with ferrite core, to be employed for magnetic stimulation of the peripheral neural system is the motivation for this work. In such applications, which rely on a capacitive discharge on the coil to realise a transient voltage curve of duration and strength suitable for neural stimulation, the correct modelling of the non-linearity of the ferrite core is critical. A demonstration of how a finite-difference model of the considered coils, which include a model of the current-controlled inductance in the coil, can be used to correctly predict the time-domain voltage waveforms across the terminals of a test coil is presented. Five coils of different dimensions, loaded with ferrite cores, have been fabricated and tested: the measured magnitude and width of the induced pulse are within 10% of simulated values.

  20. Coils and transformers - often used but seldomly explained correctly

    Lenz, Michael


    The devices coil and transformer are subjects of interest in numerous schoolbooks, in introductory scientific textbooks of physics and engineering, and in laboratory courses at universities. Many descriptions, however, draw a somewhat distorted picture of the underlying physical mechanisms and provide half-knowledge or even clear misconceptions that should not be left uncommented and are therefore studied in detail: (1) Primary and secondary voltage at a transformer have a different sign. (2) Electromagnetic induction is the only mechanism of importance for coils and transformers. (3) The terminal voltage at coils and transformers is compensated by the so-called "induced voltage" (emf), which explains why Kirchhoff's voltage law also applies to coils and transformers. (4) The cores of coils and transformers are used for their ability to store energy. Energy is transported from the primary to the secondary coil within the magnetic core. (5) The stray magnetic and electric fields are sencondary effects not havi...

  1. Improving heat transfer in stirred tanks cooled by helical coils

    S.M.C.P. Pedrosa


    Full Text Available Stirred Tank Reactors are extensively used in chemical industries. When they are used for highly exothermic reactions, jackets or coils are employed for heat removal. Internal coils can be either helical or axial and they considerably affect the flow inside the reactor because they impose an additional resistance to flow circulation. The aim of this work is to show that the design of vessels cooled by helical coils can be further improved. The design of these reactors follows very much the geometry proposed by Oldshue and Gretton (1954, and some minor modifications in the coil arrangements are likely to improve internal circulation inside these vessels mainly in the region between coils and wall of the vessel. Results show a gain in performance when small alterations are made specially in the shape of the coil arrangement.

  2. Experimental Study of Free Convection in Coiled Tube Heat Exchanger

    Harith Mohammed


    Full Text Available An experimental study has been conducted on steady-state natural convection heat transfer from helical coil tubes in vertical orientation. Water was used as a bath liquid without any mixing and cold water was used as a coolant fluid. A straight copper tube of 6 mm ID, 8 mm OD and 3 m length was bend to fabricate the helical coil. Four coils are used in this experiment has different curvature ratios and pitches. The data were correlated using tube diameter as the characteristic length. The results show that the overall heat transfer coefficient and Nusselt number increase when the flow rate of coolant and curvature ratio increase. The effect of coil pitch was investigated and the results show that when of the coil pitch (angle of inclination increases Nusselt number increase. A correlation was presented to calculate the outside average Nusselt number of coil.

  3. Performance of an induction coil gun

    Shokair, I.R.; Cowan, M.; Kaye, R.J.; Marder, B.M.


    Performance of an electromagnetic induction launcher is considered for three types of armatures. These are: Solid, 1-element wound and 16-element wound aluminum ar natures. The one element wound armature has uniform current density throughout. Because of the radial distribution of the current density, the wound armature can withstand field reversal (working against embedded flux in the armature) and still maintain low temperature. Slingshot simulations were performed, for several configurations. Best performance was obtained for a single element wound armature with two field reversals. For a 60 kg projectile, 10.5 cm coil inner radius and 5.5 cm coil build, the velocity after 50 meters of launcher length (670 stages) exceeded 3.5 km/sec with an overall efficiency of about 45%. For the same parameters the solid and 16-element wound armatures reach a velocity of about 3.3 km/sec after 800 stages (60 meters of launcher length) but without field reversal. A velocity of 3.5 km/sec is possible after 60 meters of launcher length with the 16-element wound armature with one field reversal, but the temperature is close to the melting temperature of aluminum. In all simulations with a solid armature, melting of some of the surface material occurs. However, it is shown that most of the melting occurs after contribution has been made to the forward going pressure, that is, melting does not affect the electrical performance of the launcher. The effect of coil firing tune jitter on launcher performance is also considered and is found to be very small for realistic perturbations. For {plus_minus}2 {mu}-secs random jitter, the reduction in the final velocity for a 60 meter launcher with a solid armature is less than 0.1% and the increase in temperature is only 2%. This result holds for all types of armatures.

  4. Intelligent Control on Hot Strip Coiling Temperature


    A new intelligent control scheme for hot strip coiling temperature is presented. In this scheme, the prediction model of finishing temperature and the presetting model of main cooling zone are establish based on BP neural network, the feed-forward open-loop control model of main cooling zone is constructed based on T-S fuzzy neural network, a new improved structure of T-S fuzzy neural network is developed, and the feedback close-loop control model of precision cooling zone is obtained based on fuzzy control. The effectiveness of the proposed scheme has been demonstrated by computer simulation with a satisfactory result.

  5. Extreme acoustic metamaterial by coiling up space.

    Liang, Zixian; Li, Jensen


    We show that by coiling up space using curled perforations, a two-dimensional acoustic metamaterial can be constructed to give a frequency dispersive spectrum of extreme constitutive parameters, including double negativity, a density near zero, and a large refractive index. Such an approach has band foldings at the effective medium regime without using local resonating subwavelength structures, while the principle can be easily generalized to three dimensions. Negative refraction with a double negative prism and tunneling with a density-near-zero metamaterial are numerically demonstrated.

  6. Sound Coiled-Tubing Drilling Practices

    Williams, Thomas; Deskins, Greg (Maurer Technology Inc.); Ward, Stephen L. (Advantage Energy Services Ltd); Hightower, Mel


    This Coiled-Tubing Drilling (CTD) Sound Practices Manual provides tools needed by CTD engineers and supervisors to plan, design and perform safe, successful CTD operations. As emphasized throughout, both careful planning and attention to detail are mandatory for success. A bibliography of many useful CTD references is presented in Chapter 6. This manual is organized according to three processes: 1) Pre-Job Planning Process, 2) Operations Execution Process, and 3) Post-Job Review Process. Each is discussed in a logical and sequential format.

  7. pH-dependent Response of Coiled Coils: A Coarse-Grained Molecular Simulation Study

    Enciso, Marta; Site, Luigi Delle


    In a recent work we proposed a coarse-grained methodology for studying the response of peptides when simulated at different values of pH; in this work we extend the methodology to analyze the pH-dependent behavior of coiled coils. This protein structure presents a remarkable chain stiffness andis formed by two or more long helical peptides that are interacting like the strands of a rope. Chain length and rigidity are the key aspects needed to extend previous peptide interaction potentials to this particular case; however the original model is naturally recovered when the length or the ridigity of the simulated chain are reduced. We apply the model and discuss results for two cases: (a) the folding/unfolding transition of a generic coiled coil as a function of pH; (b) behavior of a specific sequence as a function of the acidity conditions. In this latter case results are compared with experimental data from the literature in order to comment about the consistency of our approach.

  8. An autoinhibited coiled-coil design strategy for split-protein protease sensors.

    Shekhawat, Sujan S; Porter, Jason R; Sriprasad, Akshay; Ghosh, Indraneel


    Proteases are widely studied as they are integral players in cell-cycle control and apoptosis. We report a new approach for the design of a family of genetically encoded turn-on protease biosensors. In our design, an autoinhibited coiled-coil switch is turned on upon proteolytic cleavage, which results in the complementation of split-protein reporters. Utilizing this new autoinhibition design paradigm, we present the rational construction and optimization of three generations of protease biosensors, with the final design providing a 1000-fold increase in bioluminescent signal upon addition of the TEV protease. We demonstrate the generality of the approach utilizing two different split-protein reporters, firefly luciferase and beta-lactamase, while also testing our design in the context of a therapeutically relevant protease, caspase-3. Finally, we present a dual protease sensor geometry that allows for the use of these turn-on sensors as potential AND logic gates. Thus, these studies potentially provide a new method for the design and implementation of genetically encoded turn-on protease sensors while also providing a general autoinhibited coiled-coil strategy for controlling the activity of fragmented proteins.

  9. Peptidyl Materials Formed Through Click Chemistry Enhanced Coiled-Coil Interactions

    Koehler, Kenneth


    Biologically derived materials offer a level of sophistication synthetically fabricated materials have only attempted to mimic. This level of complexity may be found in materials such as peptides. Implementing new theory and modeling, peptides with the propensity to form coiled-coil (CC) bundles were designed and synthesized. Through the use of this de novo approach, modeling allowed prediction of the feasibility to include non-natural amino acids conducive to click chemistry into the peptide. Amino acids showcasing thiol or alkyne functionalities were considered owing to the ability of these moieties to participate in the thiol-ene and copper click reactions respectively. Once synthesized, the peptides decorated with these clickable motifs were placed in solution and allowed to self-assemble into CC's. CD spectroscopy and DLS experiments confirmed the formation and assembly of CC's. Click reactions were then incited to link the CC assemblies together and form a network with predictable dimensionality and pore size between CC bundles. To incite network formation, click reactions between CC side chain residues and suitably functionalized crosslinkers were implemented. The linking of coiled-coils and material formation were assessed using DLS and TEM.

  10. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments.

    Gradišar, Helena; Božič, Sabina; Doles, Tibor; Vengust, Damjan; Hafner-Bratkovič, Iva; Mertelj, Alenka; Webb, Ben; Šali, Andrej; Klavžar, Sandi; Jerala, Roman


    Protein structures evolved through a complex interplay of cooperative interactions, and it is still very challenging to design new protein folds de novo. Here we present a strategy to design self-assembling polypeptide nanostructured polyhedra based on modularization using orthogonal dimerizing segments. We designed and experimentally demonstrated the formation of the tetrahedron that self-assembles from a single polypeptide chain comprising 12 concatenated coiled coil-forming segments separated by flexible peptide hinges. The path of the polypeptide chain is guided by a defined order of segments that traverse each of the six edges of the tetrahedron exactly twice, forming coiled-coil dimers with their corresponding partners. The coincidence of the polypeptide termini in the same vertex is demonstrated by reconstituting a split fluorescent protein in the polypeptide with the correct tetrahedral topology. Polypeptides with a deleted or scrambled segment order fail to self-assemble correctly. This design platform provides a foundation for constructing new topological polypeptide folds based on the set of orthogonal interacting polypeptide segments.

  11. The AC loss evaluation of central solenoid model coil for CFETR

    Shi, Yi, E-mail:; Wu, Yu; Hao, QiangWang; Liu, Bo; Yang, Yilin


    Highlights: • In this study, The AC loss of CFETR CSMC is calculated. • The main AC losses type and mechanics of CFETR CSMC are introduced, where the hysteresis and coupling loss of Nb{sub 3}Sn and NbTi coil are estimated. • The low frequency eddy current loss calculation of stainless steel structural components is carried out by ANSYS with 3-D separate model. • In the case of conductor joints, a 3-D ANSYS code is also used to obtain the eddy current losses for the metal components. - Abstract: The AC loss of Central Solenoid Model Coil (CSMC) of China Fusion Engineering Test Reactor (CFETR) is calculated in order to be able to determine the allowable excitation current shape in time with respect to the available cooling capacity at liquid helium temperature. Firstly, the structure and operation parameters of CFETR CSMC are summarized including the superconductor, conductor and magnetic field distribution characteristic. Secondly, the main AC losses type and mechanics of CFETR CSMC are introduced, where the hysteresis and coupling loss of Nb{sub 3}Sn and NbTi coil are estimated using of the model data and a calculation flux density distribution in the cross-section of model coil by ANSYS 2-D model. Thirdly, the low frequency eddy current loss calculation of stainless steel structural components is carried out by ANSYS/EMAG code with 3-D separately for tension rods, plates and beams model. The interaction between several components is not considered. In the case of conductor joints, a 3-D ANSYS code is also used with current force to obtain the eddy current losses for the metal components. Lastly, the individual loss components are summed up. The significant conclusions are made which can provide the valuable guidance for safe operation of CSMC.

  12. Double Negativity in 3D Space Coiling Metamaterials

    Maurya, Santosh K.; Pandey, Abhishek; Shukla, Shobha; Saxena, Sumit


    Metamaterials displaying negative refractive index has remarkable potential to facilitate the manipulation of incident waves for wide variety of applications such as cloaking, superlensing and the like. Space-coiling approach is a recently explored technique to achieve extreme properties. The space coiling phenomena cause less energy absorption as compared to local resonating phenomena for obtaining extreme parameters. Here we show extreme properties in doubly negative 3D space coiling acoustic metamaterials. Frequency dispersive spectrum of extreme constitutive parameters has been calculated for 2D maze and 3D space coiling labyrinthine structure. This is in good agreement to the calculated acoustic band dispersion.

  13. Performance verification tests of JT-60SA CS model coil

    Obana, Tetsuhiro, E-mail: [National Institute for Fusion Science, 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Murakami, Haruyuki [Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan); Takahata, Kazuya; Hamaguchi, Shinji; Chikaraishi, Hirotaka; Mito, Toshiyuki; Imagawa, Shinsaku [National Institute for Fusion Science, 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Kizu, Kaname; Natsume, Kyohei; Yoshida, Kiyoshi [Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan)


    Highlights: • The performance of the JT-60SA CS model coil was verified. • The CS model coil comprised a quad-pancake wound with a Nb{sub 3}Sn CIC conductor. • The CS model coil met the design requirements. - Abstract: As a final check of the coil manufacturing method of the JT-60 Super Advanced (JT-60SA) central solenoid (CS), we verified the performance of a CS model coil. The model coil comprised a quad-pancake wound with a Nb{sub 3}Sn cable-in-conduit conductor. Measurements of the critical current, joint resistance, pressure drop, and magnetic field were conducted in the verification tests. In the critical-current measurement, the critical current of the model coil coincided with the estimation derived from a strain of −0.62% for the Nb{sub 3}Sn strands. As a result, critical-current degradation caused by the coil manufacturing process was not observed. The results of the performance verification tests indicate that the model coil met the design requirements. Consequently, the manufacturing process of the JT-60SA CS was established.

  14. Synthesis, characterisation and applications of coiled carbon nanotubes.

    Hanus, Monica J; Harris, Andrew T


    Coiled carbon nanotubes are helical carbon structures formed when heptagonal and pentagonal rings are inserted into the hexagonal backbone of a 'straight' nanotube. Coiled carbon nanotubes have been reported with both regular and irregular helical structures. In this work the structure, growth mechanism(s), synthesis, properties and potential applications of coiled carbon nanotubes are reviewed. Published data suggests that coiled carbon nanotube synthesis occurs due to nonuniform extrusion of carbon from a catalyst surface. To date, coiled carbon nanotubes have been synthesised using catalyst modification techniques including: (i) the addition of S or P containing compounds during synthesis; (ii) the use of binary or ternary metal catalysts; (iii) the use of microwaves to create a local temperature gradient around individual catalyst particles and; (iv) the use of pH control during catalyst preparation. In most instances coiled carbon nanotubes are produced as a by-product; high yield and/or large-scale synthesis of coiled carbon nanotubes remains problematic. The qualitative analysis of coiled carbon nanotubes is currently hindered by the absence of specific characterisation data in the literature, e.g., oxidation profiles measured by thermogravimetric analysis and Raman spectra of pure coiled carbon nanotube samples.

  15. The Whole Elephant: A Synoptic View of Liquid Rope Coiling

    Ribe, Neil


    Liquid rope coiling is the instability that occurs when e.g. a thin stream of honey is poured onto toast. While we now have a fine-grained understanding of each of the four principal coiling modes (viscous, gravitational, inertio-gravitational and inertial), we still lack a global view of how the modes cohere to form a larger whole. Using a numerical continuation procedure, I determine how the dimensionless coiling frequency depends on the dimensionless fall height and flow rate, for several values of the dimensionless nozzle diameter. Starting with the onset of coiling, I propose a purely geometrical definition of the critical surface between coiling and no coiling as the locus of points where the radius a1 of the rope at the contact point is just equal to the coil radius R. Coiling with a1 > R is impossible because the rope would intersect itself. I characterize the asymptotic limits of the critical surface as well as the structure of the supercritical volume inside that surface. The procedure reveals a new mode of coiling onset that has not yet been identified.

  16. Double Negativity in 3D Space Coiling Metamaterials.

    Maurya, Santosh K; Pandey, Abhishek; Shukla, Shobha; Saxena, Sumit


    Metamaterials displaying negative refractive index has remarkable potential to facilitate the manipulation of incident waves for wide variety of applications such as cloaking, superlensing and the like. Space-coiling approach is a recently explored technique to achieve extreme properties. The space coiling phenomena cause less energy absorption as compared to local resonating phenomena for obtaining extreme parameters. Here we show extreme properties in doubly negative 3D space coiling acoustic metamaterials. Frequency dispersive spectrum of extreme constitutive parameters has been calculated for 2D maze and 3D space coiling labyrinthine structure. This is in good agreement to the calculated acoustic band dispersion.

  17. Magnetic resonance imaging receiver coil decoupling using circumferential shielding structures.

    Yeh, Jhy-Neng Tasso; Fa-Hsuan Lin


    We propose a flexible phased-array design using circular coils with circumferential shielding structure to achieve robust decoupling between coil elements when the array is either bended or on a flat plane. Two types of circumferential shielding were tested through numerical simulation and imaging experiment. The results demonstrated that our arrays have good decoupling between coils when they are on a curved surface with S21 coil array. Future work will empirically construct a multi-channel array with the number of channel matched to commercial phased array in order to validate the performance in vivo.

  18. Dirty air conditioners: Energy implications of coil fouling

    Siegel, Jeffrey; Walker, Iain; Sherman, Max


    Residential air conditioning is responsible for a substantial amount of peak electrical demand and energy consumption throughout most of the United States. Coil fouling, the deposition of indoor dusts and other particulate matter on evaporator heat exchangers, increases system pressure drop and, correspondingly, decreases system air flow and air conditioner performance. In this paper, we apply experimental and simulation results describing particle deposition on evaporator coils as well as research about indoor particle and dust concentrations to determine coil fouling rates. The results suggest that typical coils foul enough to double evaporator pressure drop in about 7.5 years, much sooner than the expected 15-30 year life time for an evaporator coil. The most important parameters in determining coil fouling times are the efficiency of the filter and indoor particle concentrations, although filter bypass and duct and coil design are important as well. The reduced air flows that result from coil fouling cause typical efficiency and capacity degradations of less than 5%, however they can be much greater for marginal systems or extreme conditions. These energy issues, as well as possible indoor air quality issues resulting from fouling by biological aerosols, suggest that regular coil cleaning to ameliorate low flow and the elimination of filter bypass should be an important part of residential air conditioning commissioning and maintenance practices.

  19. Developments of RF Coil for P in vivo NMR Spectroscopy .

    S. Khushu


    Full Text Available RF receiver coils are very important parts of an NMR System. The design of these coils is very critical and has a dramatic effect on the SNR of the NMR signal and are generally developed in TRA/REC mode. This paper reports the developments of a 3.5 cm TRA/REC 26 MHz RF coil for P spectroscopy of small organs like thyroid. The coil is small in size, fits well in the neck for thyroid spectroscopy and is successfully working with the 1.5 tesla whole body Superconducting NMR System available at INMAS.

  20. Study on Wireless Power Transmission for Gastrointestinal Microsystems Based on Inductive Coupling


    Wireless power transmission based on inductive coupling for remotely implanted micro devices has been considered in this paper. The receiving coil, integrated in microsystems and the external transmitting coil compose a loosely coupled transformer. The coupling coefficient was calculated and measured on spacing misalignments. The geometric size of transmitting coil was analyzed for the target of remotely delivering power. The received power was maximized by choosing appropriate value of frequency, tuning capacitance and the load resistance. A conventional full bridge rectifier circuit was employed to convert ac to dc voltage. The Received dc power was up to 160 mW with a transmitting voltage of 5 Vrms when the receiving coil was placed at the center of the transmitting coil.This may meet the requirement of some microsystems for high power over a long time.

  1. Analysis of the cooldown of the ITER central solenoid model coil and insert coil

    Bonifetto, R.; Brighenti, A.; Isono, T.; Martovetsky, N.; Kawano, K.; Savoldi, L.; Zanino, R.


    A series of superconducting insert coils (ICs) made of different materials has been tested since 2000 at JAEA Naka in the bore of the central solenoid model coil at fields up to 13 T and currents up to several tens of kA, fully representative of the ITER operating conditions. Here we focus on the 2015 test of the presently last IC of the series, the central solenoid (CS) insert coil, which was aimed at confirming the performance and properties of the Nb3Sn conductor, manufactured in Japan and used to wind the ITER CS modules in the US. As typical for these large scale applications, the cooldown (CD) from ambient to supercritical He temperature may take a long time, of the order of several weeks, so that it should be useful, also in the perspective of future IC tests, to optimize it. To that purpose, a comprehensive CD model implemented in the 4C code is developed and presented in this paper. The model is validated against the experimental data of an actual CD scenario, showing a very good agreement between simulation and measurements, from 300 to 4.5 K. The maximum temperature difference across the coil, which can only be roughly estimated from the measurements, is then extracted from the results of the simulation and shown to be much larger than the maximum value of 50 K, prescribed on the basis of the allowable thermal stress on the materials. An optimized CD scenario is finally designed using the model for the initial phase of the CD between 300 and 80 K, which allows reducing the needed time by ∼20%, while still satisfying the major constraints. Recommendations are also given for a better location/choice of the thermometers to be used for the monitoring of the maximum temperature difference across the coil.

  2. Protective effect of speman on cisplatin-induced testicular and epididymal toxicity in mice

    S B Sainath


    Full Text Available Testicular cancer is the most common cancer affecting men of reproductive age. Advances in treatment of the disease, which includes the administration of cisplatin, have brought the 5-year survival rate to over 90%. This high cure rate, coupled with young age of patients, makes elucidation of the impact of the treatment on reproduction become increasingly important. The objective of the present study was to investigate the protective effect of speman, a non-hormonal herbal formulation, on cisplatin-induced suppressed male reproductive health in mice. Male mice were treated with cisplatin or speman alone or in combination and assessed for spermatogenesis and steroidogenesis. Significant decrease in the weights of testes and epididymis was observed in cisplatin treated animals. Injection of cisplatin significantly decreased epididymal sperm count, viable sperms, motile sperms and hypo-osmotic swelling (HOS-tail coiled sperms with a significant reduction in the testicular steroidogenic enzyme activities and serum testosterone levels, whereas co-administration of speman with cisplatin showed a significant improvement in the selected reproductive parameters over cisplatin alone treated mice indicating the beneficial effect of speman to combat cisplatin-induced suppressed reproduction in male mice.

  3. The Search Coil Magnetometer for THEMIS

    Roux, A.; Le Contel, O.; Coillot, C.; Bouabdellah, A.; de La Porte, B.; Alison, D.; Ruocco, S.; Vassal, M. C.


    THEMIS instruments incorporate a tri-axial Search Coil Magnetometer (SCM) designed to measure the magnetic components of waves associated with substorm breakup and expansion. The three search coil antennas cover the same frequency bandwidth, from 0.1 Hz to 4 kHz, in the ULF/ELF frequency range. They extend, with appropriate Noise Equivalent Magnetic Induction (NEMI) and sufficient overlap, the measurements of the fluxgate magnetometers. The NEMI of the searchcoil antennas and associated pre-amplifiers is smaller than 0.76 pT /sqrt{Hz} at 10 Hz. The analog signals produced by the searchcoils and associated preamplifiers are digitized and processed inside the Digital Field Box (DFB) and the Instrument Data Processing Unit (IDPU), together with data from the Electric Field Instrument (EFI). Searchcoil telemetry includes waveform transmission, FFT processed data, and data from a filter bank. The frequency range covered depends on the available telemetry. The searchcoils and their three axis structures have been precisely calibrated in a calibration facility, and the calibration of the transfer function is checked on board, usually once per orbit. The tri-axial searchcoils implemented on the five THEMIS spacecraft are working nominally.

  4. A novel method for coiled tubing installation

    Simpson, Peter J. [2H Offshore, Houston, TX (United States); Tibbetts, David [Aquactic Engineering and Construction Ltd., Aberdeen (United Kingdom)


    Installation of flexible pipe for offshore developments is costly due to the physical cost of the flexible pipe, expensive day rates and the availability of suitable installation vessels. Considering the scarcity of flexible pipe in today's increasingly demanding and busy market, operators are seeking a cost effective solution for installing piping in a range of water depths using vessels which are readily on hand. This paper describes a novel approach to installing reeled coiled tubing, from 1 inch to 5 inch diameter, from the back of a small vessel in water depths from 40 m up to around 1000 m. The uniqueness of the system is the fact that the equipment design is modular and compact. This means that when disassembled, it fits into standard 40 ft shipping containers, and the size allows it to be installed on even relatively small vessels of opportunity, such as anchor handling or installation vessels, from smaller, and cheaper quay side locations. Such an approach is the ideal solution to the problem faced by operators, in that it allows the installation of cheaper, readily available coiled tubing, from cost-effective vessels, which do not need to transit to a pick up the system. (author)

  5. Solutions for Safe Hot Coil Evacuation and Coil Handling in Case of Thick and High Strength Steel

    Sieberer Stefan


    Full Text Available Currently hot rolling plants are entering the market segment for thick gauges and high strength steel grades where the elastic bending property of the strip leads to internal forces in the coil during coiling operation. The strip tends to open. Primetals is investigating several possibilities to facilitate safe coil evacuation and coil handling under spring-back conditions. The contribution includes finite element models of such mechanical solutions. Results of parameter variation and stability limits of case studies are presented in the paper.

  6. Self-assembly of designed coiled coil peptides studied by small-angle X-ray scattering and analytical ultracentrifugation

    Malik, Leila; Nygaard, Jesper; Christensen, Niels Johan;


    α-Helical coiled coil structures, which are noncovalently associated heptad repeat peptide sequences, are ubiquitous in nature. Similar amphipathic repeat sequences have also been found in helix-containing proteins and have played a central role in de novo design of proteins. In addition......, they are promising tools for the construction of nanomaterials. Small-angle X-ray scattering (SAXS) has emerged as a new biophysical technique for elucidation of protein topology. Here, we describe a systematic study of the self-assembly of a small ensemble of coiled coil sequences using SAXS and analytical...

  7. Effect of inductive coil shape on sensing performance of linear displacement sensor using thin inductive coil and pattern guide.

    Misron, Norhisam; Ying, Loo Qian; Firdaus, Raja Nor; Abdullah, Norrimah; Mailah, Nashiren Farzilah; Wakiwaka, Hiroyuki


    This paper discusses the effect of inductive coil shape on the sensing performance of a linear displacement sensor. The linear displacement sensor consists of a thin type inductive coil with a thin pattern guide, thus being suitable for tiny space applications. The position can be detected by measuring the inductance of the inductive coil. At each position due to the change in inductive coil area facing the pattern guide the value of inductance is different. Therefore, the objective of this research is to study various inductive coil pattern shapes and to propose the pattern that can achieve good sensing performance. Various shapes of meander, triangular type meander, square and circle shape with different turn number of inductive coils are examined in this study. The inductance is measured with the sensor sensitivity and linearity as a performance evaluation parameter of the sensor. In conclusion, each inductive coil shape has its own advantages and disadvantages. For instance, the circle shape inductive coil produces high sensitivity with a low linearity response. Meanwhile, the square shape inductive coil has a medium sensitivity with higher linearity.

  8. Development of Ground Coils with Low Eddy Current Loss by Applying the Compression Molding Method after the Coil Winding

    Suzuki, Masao; Aiba, Masayuki; Takahashi, Noriyuki; Ota, Satoru; Okada, Shigenori

    In a magnetically levitated transportation (MAGLEV) system, a huge number of ground coils will be required because they must be laid for the whole line. Therefore, stable performance and reduced cost are essential requirements for the ground coil development. On the other hand, because the magnetic field changes when the superconducting magnet passes by, an eddy current will be generated in the conductor of the ground coil and will result in energy loss. The loss not only increases the magnetic resistance for the train running but also brings an increase in the ground coil temperature. Therefore, the reduction of the eddy current loss is extremely important. This study examined ground coils in which both the eddy current loss and temperature increase were small. Furthermore, quantitative comparison for the eddy current loss of various magnet wire samples was performed by bench test. On the basis of the comparison, a round twisted wire having low eddy current loss was selected as an effective ground coil material. In addition, the ground coils were manufactured on trial. A favorable outlook to improve the size accuracy of the winding coil and uneven thickness of molded resin was obtained without reducing the insulation strength between the coil layers by applying a compression molding after winding.

  9. Meta-analysis of stent-assisted coiling versus coiling-only for the treatment of intracranial aneurysms.

    Phan, Kevin; Huo, Ya R; Jia, Fangzhi; Phan, Steven; Rao, Prashanth J; Mobbs, Ralph J; Mortimer, Alex M


    Endovascular coil embolization is a widely accepted and useful treatment modality for intracranial aneurysms. However, the principal limitation of this technique is the high aneurysm recurrence. The adjunct use of stents for coil embolization procedures has revolutionized the field of endovascular aneurysm management, however its safety and efficacy remains unclear. Two independent reviewers searched six databases from inception to July 2015 for trials that reported outcomes according to those who received stent-assisted coiling versus coiling-only (no stent-assistance). There were 14 observational studies involving 2698 stent-assisted coiling and 29,388 coiling-only patients. The pooled immediate occlusion rate for stent-assisted coiling was 57.7% (range: 20.2%-89.2%) and 48.7% (range: 31.7%-89.2%) for coiling-only, with no significant difference between the two (odds ratio [OR}=1.01; 95% confidence intervals [CI}: 0.68-1.49). However, progressive thrombosis was significantly more likely in stent-assisted coiling (29.9%) compared to coiling-only (17.5%) (OR=2.71; 95% CI: 1.95-3.75). Aneurysm recurrence was significantly lower in stent-assisted coiling (12.7%) compared to coiling-only (27.9%) (OR=0.43; 95% CI: 0.28-0.66). In terms of complications, there was no significant difference between the two techniques for all-complications, permanent complications or thrombotic complications. Mortality was significantly higher in the stent-assisted group 1.4% (range: 0%-27.5%) compared to the coiling-only group 0.2% (range: 0%-19.7%) (OR=2.16; 95% CI: 1.33-3.52). Based on limited evidence, stent-assisted coiling shows similar immediate occlusion rates, improved progressive thrombosis and decreased aneurysm recurrence compared to coiling-only, but is associated with a higher mortality rate. Future randomized controlled trials are warranted to clarify the safety of stent-associated coiling.

  10. Voice Coil Actuator for Active Vibration Isolation in Microgravity

    Brusa, E.; Carabelli, S.; Genta, G.; Maddaleno, F.; Silvagni, M.; Tonoli, A.


    Many microgravity experiments require very low levels of acceleration which cannot be achieved on the International Space Station due to the residual vibration. A vibration isolation system is then usually devised between the experiment and the space station to obtain the desired accelerations at the experiment level. The very low frequency threshold required by the isolation specifications makes passive solutions for the isolation difficult to implement. This is mainly due to the practical impossibility of achieving high values of compliance of the elastic suspension. Furthermore, the unavoidable connections of uncertain characteristics between the experiment and the space station makes the problem even more difficult to be addressed. Disturbance reduction can be performed by means of active vibration isolation, based on magnetic suspension technology acting both at rack and at scientific experiment levels. The stiffness and damping of the active suspension can be tuned by the control loop to minimise the acceleration of the payload. The mechatronic design of an active magnetic suspension for vibration isolation in microgravity has been performed by resorting to the so-called voice-coil configuration, after a preliminary trade-off analysis of the available magnetic actuators and materials. The optimisation of the actuator layout was developed with respect to the design airgap and force density (N/kg of actuator) and force resolution requirements, by demonstrating that the configuration based on Lorentz magnetic force is more suitable for the above application in terms of stability, bi- directionality of the actuation, cross coupling effects and linearity of the force. The aim of the design was the maximisation of the actuation force/mass ratio. The FEM analysis of the voice coil allowed to investigate the flux leakage and the cross coupling effects between the actuation forces along the three principal directions of the active device. A procedure for the numerical

  11. Simulations of Twin-Box Joints for ITER PF Coils

    Ilyin, Y.; Rolando, G.; Nijhuis, A.; Simon, F.; Lim, B.S.; Mitchell, N.; Turck, B.


    An ITER Poloidal Field coil winding consists of stacked double pancakes wound with NbTi cable-in-conduit conductors. One of the critical components of the coil is the electrical joint connecting either two conductor lengths within a double pancake or two double pancakes. All joints utilize the twin-

  12. Temperature Profile Measurements During Heat Treatment of BSCCO 2212 Coils



    The temperature profile of two different BSCCO 2212 coils has been analyzed. The profiles are obtained from thermocouples imbedded in the windings during the heat treatment that activates the 2212. The melting and freezing of the 2212 is clearly observed. A model that describes the data and can be used to guide the processing of new coils has been developed.

  13. ATLAS-Lowering the first Barrel Toroid coil

    CERN Audiovisual Unit


    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 meters long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-meter diameter vertical shaft into the cavern. Then they laid the magnet to a horizontal robust platform. Images from Camera 2

  14. An Air Bearing Rotating Coil Magnetic Measurement System

    Gottschalk, Stephen C; Taylor, David J; Thayer, William


    This paper describes a rotating coil magnetic measurement system supported on air bearings. The design is optimized for measurements of 0.1micron magnetic centerline changes on long, small aperture quadrupoles. Graphite impregnated epoxy resin is used for the coil holder and coil winding forms. Coil holder diameter is 11 mm with a length between supports of 750mm. A pair of coils is used to permit quadrupole bucking during centerline measurements. Coil length is 616mm, inner radius 1.82mm, outer radius 4.74mm. The key features of the mechanical system are simplicity; air bearings for accurate, repeatable measurements without needing warm up time and a vibration isolated stand that uses a steel-topped Newport optical table with air suspension. Coil rotation is achieved by a low noise servo motor controlled by a standalone Ethernet servo board running custom servo software. Coil calibration procedures that correct wire placement errors, tests for mechanical resonances, and other system checks will also be discu...

  15. First assembly phase for the ATLAS toroid coils

    Patrice Loïez


    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. In the first phase of assembly, the two 'pancakes' are packed into their vacuum vessel. This is done using bladders filled with resin and glass microbeads under pressure. The resin is heated and, once cooled, holds the pancakes in place. The operation has to be performed on both sides of the coil, which necessitated a special technique to turn the coils over and then transport them to the heating table. Photos 01, 02, 03: Use of the overhead travelling crane to hoist the coil up and then tilt it over, the coil frame's metal feet being used as rotational pivots, supporting half the coil's weight. Once it has been turned over, the coil, now with only half the frame, is transported to the heating table using a special lifting gant...

  16. Bioaerosol deposition on an air-conditioning cooling coil

    Wu, Yan; Chen, Ailu; Luhung, Irvan; Gall, Elliott T.; Cao, Qingliang; Chang, Victor Wei-Chung; Nazaroff, William W.


    This study is concerned with the role of a fin-and-tube heat exchanger in modifying microbial indoor air quality. Specifically, depositional losses of ambient bioaerosols and particles onto dry (not cooled) and wet (cool) coil surfaces were measured for different airspeeds passing through the test coil. Total, bacterial and fungal DNA concentrations in condensate water produced by a wet coil were also quantified by means of fluorescent dsDNA-binding dye and qPCR assays. Results revealed that the deposition of bioaerosols and total particles is substantial on coil surfaces, especially when wet and cool. The average deposition fraction was 0.14 for total DNA, 0.18 for bacterial DNA and 0.22 for fungal DNA on the dry coil, increasing to 0.51 for total DNA, 0.50 for bacterial DNA and 0.68 for fungal DNA on the wet coil. Overall, as expected, deposition fractions increased with increasing particle size and increasing airspeed. Deposited DNA was removed from the cooling coil surfaces through the flow of condensing water at a rate comparable to the rate of direct deposition from air. A downward trend of bacterial and fungal DNA measured in condensate water over time provides suggestive evidence of biological growth on heat exchangers during nonoperational times of a ventilation system. This investigation provides new information about bioaerosol deposition onto a conventional fin-and-tube cooling coil, a potentially important factor influencing indoor exposure to microbial aerosols in air-conditioned buildings.

  17. Magnetic field measurements of JT-60SA CS model coil

    Obana, Tetsuhiro, E-mail: [National Institute for Fusion Science, 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Takahata, Kazuya; Hamaguchi, Shinji; Chikaraishi, Hirotaka; Mito, Toshiyuki; Imagawa, Shinsaku [National Institute for Fusion Science, 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Kizu, Kaname; Murakami, Haruyuki; Natsume, Kyohei; Yoshida, Kiyoshi [Japan Atomic Energy Agency, 801-1 Mukoyama, Naka, Ibaraki 311-0193 (Japan)


    Highlights: • Magnetic fields of the JT-60SA CS model coil were measured. • While the coil current was held constant at 20 kA, magnetic fields varied slightly with several different long time constants. • We investigated coils consisting of CIC conductors and having long time constants. - Abstract: In a cold test of the JT-60SA CS model coil, which has a quad-pancake configuration consisting of a Nb{sub 3}Sn cable-in-conduit (CIC) conductor, magnetic fields were measured using Hall sensors. For a holding coil current of 20 kA, measured magnetic fields varied slightly with long time constants in the range 17–571 s, which was much longer than the time constant derived from a measurement using a short straight sample. To validate the measurements, the magnetic fields of the model coil were calculated using a computational model representing the positions of Nb{sub 3}Sn strands inside the CIC conductor. The calculated results were in good agreement with the measurements. Consequently, the validity of the magnetic field measurements was confirmed. Next, we investigated other coils consisting of CIC conductors and having long time constants. The only commonality among the coils was the use of CIC conductors. At present, there is no obvious way to prevent generation of such magnetic-field variations with long time constants.

  18. Impulse and Frequency Response of a Moving Coil Galvanometer.

    McNeill, D. J.


    Describes an undergraduate laboratory experiment in which a moving coil galvanometer is studied and the electromotive force generated by the swinging coil provides the impulse response information in a form suitable for digitizing and inputing to a microcomputer. Background information and analysis of typical data are included. (JN)

  19. Second Barrel Toroid Coil Installed in ATLAS Cavern

    Tappern, G.

    The second barrel toroid coil was lowered into the ATLAS Cavern on Friday, 26 November. The operation takes approximately five hours of precision crane and winch operations. Before lowering, several checks are made to ensure that no loose items have been left on the coil which would fall during the lowering down the shaft. This is a very difficult, but very important check, with the first coil in position, and partly below the shaft. After changing the winch tooling on Wednesday December 1st, the coil was lifted, rotated and placed into the feet. The girders which support the coil and the Z direction stops had all been pre-set before putting the coil in the feet. The angle is controlled by an inclinometer. When the final adjustments of position have been made, which will locate the coils at the plus/minus two mm level, the connection beams (voussoirs and struts) will be put in place; this requires a complex shimming procedure. This will lock together the two coils into the feet and forms the foundation for th...

  20. ATLAS-Lowering the first Barrel Toroid coil


    Cranes lowered the first of ATLAS's eight Barrel Toroid coils into the cavern. The part is 25 metres long and the cranes had to hold the 100 tonne coil at a sharp angle while it passed through the 18-metre diameter vertical shaft into the cavern. Then they laid the magnet to a horisontal robust platform. Images from Camera 1

  1. Performance correlation between YBa2Cu3O7-δ coils and short samples for coil technology development

    Wang, X.; Dietderich, D. R.; Godeke, A.; Gourlay, S. A.; Marchevsky, M.; Prestemon, S. O.; Sabbi, G. L.


    A robust fabrication technology is critical to achieve the high performance in YBa2Cu3O{}7-δ (YBCO) coils as the critical current of the brittle YBCO layer is subject to the strain-induced degradation during coil fabrication. The expected current-carrying capability of the magnet and its temperature dependence are two key inputs to the coil technology development. However, the expected magnet performance is not straightforward to determine because the short-sample critical current depends on both the amplitude and orientation of the applied magnetic field with respect to the broad surface of the tape-form conductor. In this paper, we present an approach to calculate the self-field performance limit for YBCO racetrack coils at 77 and 4.2 K. Critical current of short YBCO samples was measured as a function of the applied field perpendicular to the conductor surface from 0 to 15 T. This field direction limited the conductor critical current. Two double-layer racetrack coils, one with three turns and the other with 10 turns, were wound and tested at 77 and 4.2 K. The test coils reached at least 80% of the expected critical current. The ratio between the coil critical currents at 77 and 4.2 K agreed well with the calculation. We conclude that the presented approach can determine the performance limit in YBCO racetrack coils based on the short-sample critical current and provide a useful guideline for assessing the coil performance and fabrication technology. The correlation of the coil critical current between 77 K and 4.2 K was also observed, allowing the 77 K test to be a cost-effective tool for the development of coil technology.

  2. Impact of coil price knowledge by the operator on the cost of aneurysm coiling. A single center study.

    Finitsis, Stephanos; Fahed, Robert; Gaulin, Ian; Roy, Daniel; Weill, Alain


    Endovascular treatment of aneurysms with coils is among the most frequent treatments in interventional neuroradiology, and represents an important expense. Each manufacturer has created several types of coils, with prices varying among brands and coil types. The objective of this study was to assess the impact of cost awareness of the exact price of each coil by the operating physician on the total cost of aneurysm coiling. This was a comparative study conducted over 1 year in a single tertiary care center. The reference cohort and the experimental cohort consisted of all aneurysm embolization procedures performed during the first 6 months and the last 6 months, respectively. During the second period, physicians were given an information sheet with the prices of all available coils and were requested to look at the sheet during each procedure with the instruction to try to reduce the total cost of the coils used. Expenses related to the coiling procedures during each period were compared. 77 aneurysms (39 ruptured) in the reference cohort and 73 aneurysms (36 ruptured) in the experimental cohort were treated, respectively. There was no statistically significant difference regarding aneurysm location and mean size. The overall cost of the coiling procedures, the mean number of coils used per procedure, and the median cost of each procedure did not differ significantly between the two cohorts. Awareness of the precise price of coils by operators without any additional measure did not have a scientifically proven impact on the cost of aneurysm embolization. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Wireless power transfer via strongly coupled magnetic resonances.

    Kurs, André; Karalis, Aristeidis; Moffatt, Robert; Joannopoulos, J D; Fisher, Peter; Soljacic, Marin


    Using self-resonant coils in a strongly coupled regime, we experimentally demonstrated efficient nonradiative power transfer over distances up to 8 times the radius of the coils. We were able to transfer 60 watts with approximately 40% efficiency over distances in excess of 2 meters. We present a quantitative model describing the power transfer, which matches the experimental results to within 5%. We discuss the practical applicability of this system and suggest directions for further study.

  4. Temperature dependence of the PER in PM-PCF coil

    Hong Zhao; Meng Chen; Gang Li


    A piece of domestic polarization-maintaining photonic crystal fiber (PM-PCF,964 m in length) is made into a fiber coil,and its polarization extinction ratio (PER) is measured in a temperature range of -45-80 ℃ before and after PM-PCF is wound and solidified.A fiber coil made of commercial panda PM fiber (PMF) is also fabricated and measured for comparison.Our experiments show that the PER variation of the PM-PCF coil (2.25 dB) is far smaller than that of the panda PMF coil (10 dB) in the whole temperature range because PM-PCF is intrinsically insensitive to the temperature variation and stress in the fiber coil induced by the winding and solidification process.This characteristic is important for the real application of PM-PCFs in temperature-insensitive fiber interferometers,fiber sensors,and optical fiber gyroscopes.

  5. Electromagnetic Design of Superconducting Dipoles Based on Sector Coils

    Todesco, Ezio


    We study the coil lay-outs of superconducting dipoles for particle accelerators based on the sector geometry. We show that a simple model based on a sector coil with a wedge allows us to derive an equation giving the short sample field as a function of the aperture, coil width, cable properties and superconducting material. The equation agrees well with the actual results of several dipole coils that have been built in the last 30 years. The improvements due to the grading technique and the iron yoke are also studied. The proposed equation can be used as a benchmark to judge the efficiency of the coil design, and to carry out a global optimization of an accelerator lay-out.

  6. First assembly phase for the ATLAS toroid coils

    Maximilien Brice


    The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. In the first phase of assembly, the two 'pancakes' are packed into their vacuum vessel. This is done using bladders filled with resin and glass microbeads under pressure. The resin is heated and, once cooled, holds the pancakes in place. The operation has to be performed on both sides of the coil, which necessitated a special technique to turn the coils over and then transport them to the heating table. Photos 01, 02, 03: Transporting the coil to the heating table using a special lifting gantry manufactured at JINR-Dubna, Russia in preparation for the 'bladderisation' operation.

  7. Dual cervical thoracic coil for spine magnetic resonance imaging

    Totterman, S.; Foster, T.H.; Plewes, D.B.; Simon, J.H.; Ekholm, S.; Wicks, A. (Rochester Univ., NY (USA). Dept. of Radiology Rochester Univ., NY (USA). Dept. of Physics and Astronomy)

    The need for repositioning of surface coils and patients in MR examinations of the cervical and thoracic spin prolongs examination time. A new receiver design is proposed which overcomes this problem. The device is composed of two actively decoupled receiver coils mounted on the frame of a Philadelphia collar. These coils may be used separately to image either the thoracic or cervical spine or together to produce larger field-of-view images of the combined region. Signal-to-noise ratios of the separate cervical and thoracic spine images are not degraded as a result of mounting the receivers together. The full cervical and thoracic region is shown to be imaged at a signal-to-noise ratio significantly higher than that afforded by the body coil. A retrospective review of our case load suggests that a time saving could be achieved in approximately 1/3 of spine examinations by using this coil. (orig.).

  8. Analysis of brushless DC generator incorporating an axial field coil

    Moradi, Hassan, E-mail: [Department of Electrical and Computer Engineering, Shahid Beheshti University, GC, Tehran (Iran, Islamic Republic of); Afjei, E. [Department of Electrical and Computer Engineering, Shahid Beheshti University, GC, Tehran (Iran, Islamic Republic of)


    Highlights: {yields} Magnetic analysis and experiment of a three-phase field assisted BLDC generator. {yields} Confirm the accuracy of the predicted flux-linkage by 2-D FE analysis. {yields} Confirm the accuracy of the FE analysis results by coupling the FE and BE method. {yields} Control the output voltage to a desired level by control the amplitude of the I{sub f}. {yields} Compatible with any application that requires variable speed operation. -- Abstract: This paper describes the magnetic analysis and experiment of a three-phase field assisted brushless DC (BLDC) generator. Unlike conventional BLDC generators, the permanent magnet is replaced with an assisted field winding. The stator and rotor are constructed with two dependent magnetically sets, in which each stator set includes nine salient poles with coil windings, and the rotor comprises of six salient poles. Other pole combinations also are possible. This construction is similar to a homopolar inductor alternator. The DC current in the assisted field winding produces axial flux which makes the rotor magnetically polarized at its ends. The magnetic field flows axially through the rotor shaft and closes through the stator teeth and the machine housing. To evaluate the generator performance, two types of analysis, namely the numerical technique and the experimental study have been utilized. In the numerical analysis, 2-D finite element (FE) analysis has been carried out using a MagNet CAD package (Infolytica Corporation Ltd.), to confirm the accuracy of the predicted flux-linkage characteristics, whereas in the experimental study, a prototype BLDC generator was constructed for verifying the actual performance. Furthermore, the evaluation method based on a hybrid numerical method coupling the finite element (FE) analysis and boundary element (BE) method, has been carried out to confirm the accuracy of the 2-D FE analysis simulation results. It provides not only confirmations of the investigation in results

  9. Nonlinear Dynamics of Coiling in Viscoelastic Jets

    Majmudar, Trushant; Hartt, William; McKinley, Gareth


    Instabilities in free surface continuous jets of non-Newtonian fluids, although relevant for many industrial processes, remain less well understood in terms of fundamental fluid dynamics. Inviscid, and viscous Newtonian jets have been studied in great detail; buckling instability in viscous jets leads to regular periodic coiling of the jet that exhibits a non-trivial frequency dependence with the height of the fall. Very few experimental or theoretical studies exist for continuous viscoelastic jets beyond the onset of the first instability. Here, we present a systematic study of the effects of viscoelasticity on the dynamics of free surface continuous jets of surfactant solutions that form worm-like micelles. We observe complex nonlinear spatio-temporal dynamics of the jet and uncover a transition from periodic to doubly-periodic or quasi-periodic to a multi-frequency, possibly chaotic dynamics. Beyond this regime, the jet dynamics smoothly crosses over to exhibit the "leaping shampoo effect" or the Kaye effe...

  10. Transformer current sensor for superconducting magnetic coils

    Shen, Stewart S.; Wilson, C. Thomas


    A transformer current sensor having primary turns carrying a primary current for a superconducting coil and secondary turns only partially arranged within the primary turns. The secondary turns include an active winding disposed within the primary turns and a dummy winding which is not disposed in the primary turns and so does not experience a magnetic field due to a flow of current in the primary turns. The active and dummy windings are wound in opposite directions or connected in series-bucking relationship, and are exposed to the same ambient magnetic field. Voltages which might otherwise develop in the active and dummy windings due to ambient magnetic fields thus cancel out. The resultant voltage is purely indicative of the rate of change of current flowing in the primary turns.

  11. Design of the low-loss waveguide coil for interferometric integrated optic gyroscopes

    Fei, Yao; Yang, Tianshu; Li, Zhaofeng; Liu, Wen; Wang, Xiaodong; Zheng, Wanhua; Yang, Fuhua


    With the development of manufacturing technology, the propagation loss of the planar waveguide is getting lower and lower, and the shot-noise-limited sensitivity of an IIOG will be greatly improved. When the propagation loss is getting lower, improper coupling-out waveguide in the waveguide coil may lead to non-ignorable bending loss and crosstalk because of the small radius of curvature and X-junction. In this paper, different coupling-out waveguides have been designed. After calculation and optimization by the beam propagation method, we found the proper coupling-out waveguide having relatively low propagation loss, which can improve the sensitivity of the IIOG. Project supported by the National Natural Science Foundation of China (Nos. 61274066, 61504138, 61474115) and the National Key Research and Development Program of China (No. 2016YFA02005003).

  12. Antibody engineering using phage display with a coiled-coil heterodimeric Fv antibody fragment.

    Xinwei Wang

    Full Text Available A Fab-like antibody binding unit, ccFv, in which a pair of heterodimeric coiled-coil domains was fused to V(H and V(L for Fv stabilization, was constructed for an anti-VEGF antibody. The anti-VEGF ccFv showed the same binding affinity as scFv but significantly improved stability and phage display level. Furthermore, phage display libraries in the ccFv format were constructed for humanization and affinity maturation of the anti-VEGF antibody. A panel of V(H frameworks and V(H-CDR3 variants, with a significant improvement in affinity and expressibility in both E. coli and yeast systems, was isolated from the ccFv phage libraries. These results demonstrate the potential application of the ccFv antibody format in antibody engineering.

  13. De novo designed coiled-coil proteins with variable conformations as components of molecular electronic devices.

    Shlizerman, Clara; Atanassov, Alexander; Berkovich, Inbal; Ashkenasy, Gonen; Ashkenasy, Nurit


    Conformational changes of proteins are widely used in nature for controlling cellular functions, including ligand binding, oligomerization, and catalysis. Despite the fact that different proteins and artificial peptides have been utilized as electron-transfer mediators in electronic devices, the unique propensity of proteins to switch between different conformations has not been used as a mechanism to control device properties and performance. Toward this aim, we have designed and prepared new dimeric coiled-coil proteins that adopt different conformations due to parallel or antiparallel relative orientations of their monomers. We show here that controlling the conformation of these proteins attached as monolayers to gold, which dictates the direction and magnitude of the molecular dipole relative to the surface, results in quantitative modulation of the gold work function. Furthermore, charge transport through the proteins as molecular bridges is controlled by the different protein conformations, producing either rectifying or ohmic-like behavior.

  14. Treatment of Intracranial Aneurysms: Clipping Versus Coiling.

    Liu, Ann; Huang, Judy


    Intracranial aneurysms (IAs) have an estimated incidence of up to 10 % and can lead to serious morbidity and mortality. Because of this, the natural history of IAs has been studied extensively, with rupture rates ranging from 0.5 to 7 %, depending on aneurysm characteristics. The spectrum of presentation of IAs ranges from incidental detection to devastating subarachnoid hemorrhage. Although the gold standard imaging technique is intra-arterial digital subtraction angiography, other modalities such as computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are being increasingly used for screening and treatment planning. Management of these patients depends upon a number of factors including aneurysmal, patient, institutional, and operator factors. The ultimate goal of treating patients with IAs is complete and permanent occlusion of the aneurysm sac in order to eliminate future hemorrhagic risk, while preserving or restoring the patient's neurological function. The most common treatment approaches include microsurgical clipping and endovascular coiling, and multiple studies have compared these two techniques. To date, three large prospective, randomized studies have been done: a study from Finland, International Subarachnoid Aneurysm Trial (ISAT), and the Barrow Ruptured Aneurysm Trial (BRAT). Despite differences in methodology, the results were similar: in patients undergoing coiling, although rates of rebleeding and retreatment are higher, the overall rate of poor outcomes at 12 months was significantly lower. As minimally invasive procedures and devices continue to be refined, endovascular strategies are likely to increase in popularity. However, as long-term outcome studies become available, it is increasingly apparent that they are complementary treatment strategies, with patient selection of critical importance.

  15. Research on automatic non-destructive testing system of oil coiled tubing

    Guo, Rong; Qiu, Wenbin; Wang, Yuhui; Ren, Jianguang


    A method using ultrasonic devices for on-line measurement of oil coiled tubing was proposed. The principle of ultrasonic testing was analyzed. Then, the structure of the system consisting of mechanical system, coupling system, measuring system, control system and system software was determinated. Based on the analysis of technology requirement, measuring technique in which the coiled tubing did not rotate and the probe was static was chosen. The ultrasonic testing probes were triggered in turn. After signal sampling, digital filtering and A / D conversion signal processing, the received echo signals were sent to computer. Through analyzing and accounting, the test results were obtained. Based on, A-type ultrasonic and C-type ultrasonic display software and the inspection data processing software were developed. Using Windows programming technology, the software structure and function library were totally open. Therefore, secondary development can be carried out conveniently. Based on the experimental studies, coiled tubing's ultrasonic testing system is developed. The testing results show that the system has specific advantages such as high-adaptation, highefficiency, high- stability, high reliability and can meet the need of the users. The ultrasonic testing technologies proposed in this paper can be applied extensively to other tubes.

  16. Thermodynamics of coil-hyperbranched poly(styrene-b-acrylated epoxidized soybean oil) block copolymers

    Lin, Fang-Yi; Hohmann, Austin; Hernández, Nacú; Cochran, Eric

    Here we present the phase behavior of a new type of coil-hyperbranched diblock copolymer: poly(styrene- b-acrylated epoxidized soybean oil), or PS-PAESO. PS-PAESO is an example of a biorenewable thermoplastic elastomer (bio-TPE). To date, we have shown that bio-TPEs can be economical commercial substitutes for their petrochemically derived analogues--such as poly(styrene- b-butadiene- b-styrene) (SBS)--in a range of applications including pressure sensitive adhesives and bitumen modification. From a polymer physics perspective, PS-PAESO is an interesting material in that it couples a linear coil-like block with a highly branched block. Thus in contrast to the past five decades of studies on linear AB diblock copolymers, coil-hyperbranched block copolymers are relatively unknown to the community and can be expected to deviate substantially from the standard ``universal'' phase behavior in the AB systems. To explore these new materials, we have constructed a library of PS-PAESO materials spanning a range of molecular weight and composition values. The phase transition behavior and the morphology information will be interpreted by isochronal temperature scanning in dynamic shear rheology, small angle X-ray scattering and the corresponding transmission electron microscopy.

  17. D-Cysteine Ligands Control Metal Geometries within de Novo Designed Three-Stranded Coiled Coils.

    Pecoraro, Vincent Louis; Ruckthong, Leela; Peacock, Anna F A; Pascoe, Cherilyn E; Hemmingsen, Lars; Stuckey, Jeanne A


    While metal ion binding to naturally occurring L-amino acid proteins is well documented, understanding the impact of the opposite chirality (D) amino acids on the structure and stereochemistry of metals is in its infancy. We examine the effect of a D-configuration cysteine within a designed L-amino acid three-stranded coiled coil in order to enforce a precise coordination number on a metal center. The D-chirality does not alter the native fold, but the side-chain reorientation modifies the sterics of the metal binding pocket. L-Cys side-chains within the coiled-coil have previously been shown to rotate substantially from their preferred positions in the apo structure to create a binding site for a tetra-coordinate metal ion. However, here we show by x-ray crystallography that D-Cys side chains are preorganized with suitable geometry to bind such a ligand. This is confirmed by comparison of the Zn(II)Cl(CSL16DC)₃²¯ to the published Zn(II)(H₂O)(GRAND-CSL12AL16LC)₃¯.¹ Spectroscopic analysis indicates that the Cd(II) geometry observed using L-Cys ligands (a mixture of 3- and 4- coordinate Cd(II)) is altered to a single 4-coordinate specie when D-Cys is present. This work opens a new avenue for the control of metal site environment in man-made proteins, by simply altering the binding ligand with its mirror imaged D-configuration. Thus, use of D amino acids in a metal's coordination sphere promises to be a powerful tool for controlling the properties of future metalloproteins.

  18. A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex

    Wiederhold, Katrin; Kloepper, Tobias H; Walter, Alexander M;


    to the preformed syntaxin 1.SNAP-25 dimer. Exactly how this step relates to neurotransmitter release is not well understood. Here, we combined different approaches to gain insights into this reaction. Using computational methods, we identified a stretch in synaptobrevin 2 that may function as a coiled coil...

  19. A Novel Optimization Means of Transfer Efficiency for Resonance Coupled Wireless Power Transfer

    Tan Linlin


    Full Text Available When the transmitting and receiving coils are equivalent with or not significantly smaller than their separation distance between the two coils, the results of numerical simulations for transfer efficiency of system show that the maximum coupling of two coils or maximum transfer efficiency occur with a certain tilt angle between two coils, which means the two coils with parallel on the same axis is not able to obtain the maximum transmission efficiency. In view of this feature of the wireless power transfer system, we propose a novel means to optimize the transfer efficiency by designing rotatable transmitting coils to achieve the appropriate tile angle. The experimental results show that the presented means is efficient and greatly improves the transfer efficiency.

  20. Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

    Cooper, Ayelet; Grigoryan, Gayane; Guy-David, Liora; Tsoory, Michael M; Chen, Alon; Reuveny, Eitan


    G protein-activated inwardly rectifying K+ channels (GIRK) generate slow inhibitory postsynaptic potentials in the brain via Gi/o protein-coupled receptors. GIRK2, a GIRK subunit, is widely abundant in the brain and has been implicated in various functions and pathologies, such as learning and memory, reward, motor coordination, and Down syndrome. Down syndrome, the most prevalent cause of mental retardation, results from the presence of an extra maternal chromosome 21 (trisomy 21), which com...

  1. Stenting plus coiling: dangerous or helpful?; Stenting plus Coiling bei akut rupturierten intrakraniellen Aneurysmen

    Wanke, I.; Gizewski, E.; Doerfler, A.; Stolke, D.; Forsting, M. [Essen Univ. (Germany). Inst. fuer Radiologie und Neuroradiologie


    Purpose: the purpose of this study was to evaluate the procedural risk of treating acute ruptured aneurysms with a stentcoil combination. Material and methods: between August 2001 and January 2004 we treated nine acute subarachnoid hemorrhage (SAH) patients with a combination of stents and platinum coils. Results: six aneurysms were 100% eliminated; the residual three aneurysms had a 95% to 99% occlusion. A transient thrombosis in the stent in one patient could be recanalized by intravenous application of ReoPro {sup registered}. In another patient an occlusive vasospasm at the distal end of the stent was successfully treated with intraarterial Nimotop {sup registered}. Neurological complications occurred in none of the patients. Conclusion: in broad-based aneurysms which cannot be clipped or in which any neurosurgical treatment presents an unacceptably high risk (posterior circulation and paraophthalmic aneurysms), treatment using a combination of stent and platinum coils might be an option even in the acute phase of an SAH. Platelet aggregation can be treated with Aspirin registered and Plavix {sup registered} after placement of the first coil, vasospasms with intraarterial Nimotop {sup registered}, and acute stent thrombosis with GP IIa/IIIb-antagonists. (orig.)

  2. Self and transfer impedances of coaxial coils for interrogating a borehole formation

    Yu, J. S.


    Analytical models for coaxial-coil logging were improved to permit a self-consistent and accurate evaluation of formation rocks using multiple frequencies within 10 to 100 MHz. For typical borehole diameters up to 20 cm, the inclusion of magnetic-quadrupole coupling allows the self and transfer impedances to be accurately calibrated during design, and self-consistently measured during downhole interrogation. Comprehensive processings of the measurable Z/sub 11/ and Z/sub 21/ are expected to enhance the uniqueness of evaluating the properties of reservoir rocks.

  3. A new metal detection method based on balanced coil for mobile phone wireless charging system

    Zhou, B.; Liu, Z. Z.; Chen, H. X.; Zeng, H.; Hei, T.


    The wireless charging time of mobile phone will increase greatly if the metal objects mix in the magnetic field coupling area. In addition, the fire may be caused as for the high temperature of metal objects. The paper proposed an improved detecting method based on balance coil for mobile phone wireless charging system according to comparing the advantages and disadvantages of traditional metal detection methods. The circuit model was established, and hardware and software were optimized. At last, experimental results verified the theoretical analysis.

  4. Discrete Differential Geometry Applied to the Coil-End Design of Superconducting Magnets

    Auchmann, B; Schwerg, N


    Coil-end design for superconducting accelerator magnets, based on the continuous strip theory of differential geometry, has been introduced by Cook in 1991. A similar method has later been coupled to numerical field calculation and used in an integrated design process for LHC magnets within the CERN field computation program ROXIE. In this paper we present a discrete analog on to the continuous theory of strips. Its inherent simplicity enhances the computational performance, while reproducing the accuracy of the continuous model. The method has been applied to the design

  5. Liquid Hydrogen Absorber for MICE

    Ishimoto, S.; Suzuki, S.; Yoshida, M.; Green, Michael A.; Kuno, Y.; Lau, Wing


    Liquid hydrogen absorbers for the Muon Ionization Cooling Experiment (MICE) have been developed, and the first absorber has been tested at KEK. In the preliminary test at KEK we have successfully filled the absorber with {approx}2 liters of liquid hydrogen. The measured hydrogen condensation speed was 2.5 liters/day at 1.0 bar. No hydrogen leakage to vacuum was found between 300 K and 20 K. The MICE experiment includes three AFC (absorber focusing coil) modules, each containing a 21 liter liquid hydrogen absorber made of aluminum. The AFC module has safety windows to separate its vacuum from that of neighboring modules. Liquid hydrogen is supplied from a cryocooler with cooling power 1.5 W at 4.2 K. The first absorber will be assembled in the AFC module and installed in MICE at RAL.

  6. Magnetic eye tracking in mice.

    Payne, Hannah L; Raymond, Jennifer L


    Eye movements provide insights about a wide range of brain functions, from sensorimotor integration to cognition; hence, the measurement of eye movements is an important tool in neuroscience research. We describe a method, based on magnetic sensing, for measuring eye movements in head-fixed and freely moving mice. A small magnet was surgically implanted on the eye, and changes in the magnet angle as the eye rotated were detected by a magnetic field sensor. Systematic testing demonstrated high resolution measurements of eye position of eye tracking offers several advantages over the well-established eye coil and video-oculography methods. Most notably, it provides the first method for reliable, high-resolution measurement of eye movements in freely moving mice, revealing increased eye movements and altered binocular coordination compared to head-fixed mice. Overall, magnetic eye tracking provides a lightweight, inexpensive, easily implemented, and high-resolution method suitable for a wide range of applications.

  7. Design of transverse head gradient coils using a layer-sharing scheme

    Wang, Yaohui; Liu, Feng; Zhou, Xiaorong; Crozier, Stuart


    In this paper, a new design for transverse asymmetric head gradient coils is proposed for Magnetic Resonance Imaging (MRI). Unlike the conventional coil designs where the x and y coils are placed onto separate radial layers, the new design has windings for both the x and y coils in each transverse coil layer. The coil performance using the new design was compared with the conventional coils with the same dimensions and constraints. The results showed that the new design can improve coil performance in terms of a lower inductance, lower resistance and a higher figure of merit.

  8. Review of the ATLAS B0 model coil test program

    Dolgetta, N; Acerbi, E; Berriaud, C; Boxman, H; Broggi, F; Cataneo, F; Daël, A; Delruelle, N; Dudarev, A; Foussat, A; Haug, F; ten Kate, H H J; Mayri, C; Paccalini, A; Pengo, R; Rivoltella, G; Sbrissa, E


    The ATLAS B0 model coil has been extensively tested, reproducing the operational conditions of the final ATLAS Barrel Toroid coils. Two test campaigns have taken place on B0, at the CERN facility where the individual BT coils are about to be tested. The first campaign aimed to test the cool-down, warm-up phases and to commission the coil up to its nominal current of 20.5 kA, reproducing Lorentz forces similar to the ones on the BT coil. The second campaign aimed to evaluate the margins above the nominal conditions. The B0 was tested up to 24 kA and specific tests were performed to assess: the coil temperature margin with respect to the design value, the performance of the double pancake internal joints, static and dynamic heat loads, behavior of the coil under quench conditions. The paper reviews the overall test program with emphasis on second campaign results not covered before. 10 Refs.


    M.Y. Gu; G. Chen; M.C. Zhang; X.C. Dai


    The mathematical model has been established for the simulation of steel coil's heat transfer during annealing thermal process in HPH (high performance hydrogen) furnace. The equivalent radial thermal conductivity is adopted by statistical analysis regression approach through the combination of a large quantity of production data collected in practice and theoretical analyses. The effect of the number of coils on circulating flow gas is considered for calculating the convection heat transfer coefficient. The temperature within the coil is predicted with the developed model during the annealing cycle including heating process ard cooling process. The good consistency between the predicted results and the experimental data has demonstrated that the mathematical model established and the parameters identified by this paper are scientifically feasible and the effective method of calculation for coil equivalent radial heat transfer coefficient and circulating gas flow has been identified successfully, which largely enhances the operability and feasibility of the mathematic model. This model provides a theoretical basis and an effective means to conduct studies on the impact that foresaid factors may imposed on the steel coil's temperature field, to analyze the stress within coils, to realize online control and optimal production and to increase facility output by increasing heating and cooling rates of coils without producing higher thermal stress.

  10. The noise factor of receiver coil matching networks in MRI.

    Cao, Xueming; Fischer, Elmar; Gruschke, Oliver; Korvink, Jan G; Hennig, Jürgen; Maunder, Adam M; De Zanche, Nicola; Zaitsev, Maxim


    In typical MRI applications the dominant noise sources in the received signal are the sample, the coil loop and the preamplifier. We hypothesize that in some cases (e.g. for very small receiver coils) the matching network noise has to be considered explicitly. Considering the difficulties of direct experimental determinations of the noise factor of matching networks with sufficient accuracy, it is helpful to estimate the noise factor by calculation. A useful formula of the coil matching network is obtained by separating commonly used coil matching network into different stages and calculating their noise factor analytically by a combination of the noise from these stages. A useful formula of the coil matching network is obtained. ADS simulations are performed to verify the theoretical predictions. Thereafter carefully-designed proof-of-concept phantom experiments are carried out to qualitatively confirm the predicted SNR behavior. The matching network noise behavior is further theoretically investigated for a variety of scenarios. It is found that in practice the coil matching network noise can be improved by adjusting the coil open port resonant frequency.




    OAK-B135 The magnetic diagnostics program at DIII-D adds to its in-vessel installations of induction-type loops and coils almost every year. The current design of toroidal and poloidal magnetic field coils (45-50 kHz, N {center_dot} A = 0.06 m{sup 2}) has been in existence since 1987. Many coils were installed in DIII-D during that year and are still operating and reliable today. The high reliability of the coils is owing to the use of a continuous length of mineral-insulated cable, eliminating any electrical connections inside the vacuum vessel. The geometry of the probes was designed to achieve a bandwidth of 50 kHz, despite the conducting shell formed by the stainless steel sheath of the mineral-insulated cable. The bandwidth is sensitive to the details of the cable dimensions and winding technique, and care must be taken in the fabrication in order to maintain this specification. With possible future magnetic diagnostics installations IN ITER and other long-pulse machines requiring large numbers of coils and/or multiple layers per coil, the manufacturing scale-up, quality control, and the development of layered coils should all be investigated in addition to the obvious issues such as irradiation effects.

  12. Endothelial cell proliferation in swine experimental aneurysm after coil embolization.

    Yumiko Mitome-Mishima

    Full Text Available After coil embolization, recanalization in cerebral aneurysms adversely influences long-term prognosis. Proliferation of endothelial cells on the coil surface may reduce the incidence of recanalization and further improve outcomes after coil embolization. We aimed to map the expression of proliferating tissue over the aneurysmal orifice and define the temporal profile of tissue growth in a swine experimental aneurysm model. We compared the outcomes after spontaneous thrombosis with those of coil embolization using histological and morphological techniques. In aneurysms that we not coiled, spontaneous thrombosis was observed, and weak, easily detachable proliferating tissue was evident in the aneurysmal neck. In contrast, in the coil embolization group, histological analysis showed endothelial-like cells lining the aneurysmal opening. Moreover, immunohistochemical and morphological analysis suggested that these cells were immature endothelial cells. Our results indicated the existence of endothelial cell proliferation 1 week after coil embolization and showed immature endothelial cells in septal tissue between the systemic circulation and the aneurysm. These findings suggest that endothelial cells are lead to and proliferate in the former aneurysmal orifice. This is the first examination to evaluate the temporal change of proliferating tissue in a swine experimental aneurysm model.

  13. Fetal MRI on a multi-element digital coil platform

    Serai, Suraj D.; Merrow, Arnold C.; Kline-Fath, Beth M. [Cincinnati Children' s Hospital Medical Center, Department of Radiology, 3333 Burnett Ave., MLC 5031, Cincinnati, OH (United States)


    Fetal MRI has an increasing list of indications and is most commonly employed when anomalies detected by prenatal ultrasonography require further characterization. This may occur when sonography is technically challenging or where specific MRI findings will determine pre- and postnatal management, including critical in utero and/or peripartum interventions. In these circumstances, there are high expectations for MRI to sort out complex diagnostic dilemmas through exquisite anatomical imaging that fetal surgeons and obstetricians can comprehend and relay to their patients. These expectations, in light of evolving clinical innovations, continue to drive advances in fetal imaging. Increasing signal-to-noise ratio (SNR) is fundamental to improving MR image quality, and proper coil selection is a key component of this pursuit. Since the introduction of parallel imaging techniques, the numbers of elements in phased-array coils have been continuously increased to achieve high SNR and shorter scan times. With the invention of a digital coil platform, it is now possible to connect combinations of multiple coil elements to enhance SNR beyond the capabilities of the adult eight-channel torso-coil routinely used in fetal imaging. This paper describes the application of multi-element radiofrequency coils on a digital broadband imaging platform with unique coil combinations to perform dedicated fetal MRI. (orig.)

  14. A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T.

    Serés Roig, Eulalia; Magill, Arthur W; Donati, Guillaume; Meyerspeer, Martin; Xin, Lijing; Ipek, Ozlem; Gruetter, Rolf


    Carbon-13 magnetic resonance spectroscopy ((13) C-MRS) is challenging because of the inherent low sensitivity of (13) C detection and the need for radiofrequency transmission at the (1) H frequency while receiving the (13) C signal, the latter requiring electrical decoupling of the (13) C and (1) H radiofrequency channels. In this study, we added traps to the (13) C coil to construct a quadrature-(13) C/quadrature-(1) H surface coil, with sufficient isolation between channels to allow simultaneous operation at both frequencies without compromise in coil performance. Isolation between channels was evaluated on the bench by measuring all coupling parameters. The quadrature mode of the quadrature-(13) C coil was assessed using in vitro (23) Na gradient echo images. The signal-to-noise ratio (SNR) was measured on the glycogen and glucose resonances by (13) C-MRS in vitro, compared with that obtained with a linear-(13) C/quadrature-(1) H coil, and validated by (13) C-MRS in vivo in the human calf at 7T. Isolation between channels was better than -30 dB. The (23) Na gradient echo images indicate a region where the field is strongly circularly polarized. The quadrature coil provided an SNR enhancement over a linear coil of 1.4, in vitro and in vivo. It is feasible to construct a double-quadrature (13) C-(1) H surface coil for proton decoupled sensitivity enhanced (13) C-NMR spectroscopy in humans at 7T. © 2014 Wiley Periodicals, Inc.

  15. MEMS switch integrated radio frequency coils and arrays for magnetic resonance imaging

    Bulumulla, S. B.; Park, K. J.; Fiveland, E.; Iannotti, J.; Robb, F.


    Surface coils are widely used in magnetic resonance imaging and spectroscopy. While smaller diameter coils produce higher signal to noise ratio (SNR) closer to the coil, imaging larger fields of view or greater distance into the sample requires a larger overall size array or, in the case of a channel count limited system, larger diameter coils. In this work, we consider reconfiguring the geometry of coils and coil arrays such that the same coil or coil array may be used in multiple field of view imaging. A custom designed microelectromechanical systems switch, compatible with magnetic resonance imaging, is used to switch in/out conductive sections and components to reconfigure coils. The switch does not degrade the SNR and can be opened/closed in 10 μ s, leading to rapid reconfiguration. Results from a single coil, configurable between small/large configurations, and a two-coil phased array, configurable between spine/torso modes, are presented.

  16. Improvement of Prediction Method for Strip Coiling Temperature

    YU Qing-bo; WANG Zhao-dong; WANG Zhe-ying; LIU Xiang-hua; WANG Guo-dong


    In order to improve the control precision of strip coiling temperature for hot strip mill, the BP neural network was combined with mathematical model to calculate convective heat-transfer coefficient of laminar flow cooling. The off-line calculated results indicate that the standard deviation of coiling temperature prediction is reduced by 22.84 % with the convective heat-transfer coefficient calculated by BP neural network. The prospects of this method for on-line application are bright. This method is more helpful to increasing the control precision of coiling temperature for hot strip steel.

  17. Design and manufacturing of a Wendelstein 7-X demonstration coil

    Kronhardt, H. [Preussag Noell GmbH, Wuerzburg (Germany); Dormicchi, O. [Ansalto Energia, Genoa (Italy); Sapper, J. [Max-Planck-Institut fuer Plasmaphysik, Garching (Germany)


    The large Stellarator experiment Wendelstein 7-X is currently being constructed at the Max-Planck-Institute for Plasma physics (IPP). The magnet system consists of 50 non-planar and 20 planar superconducting coils. A full-size non-planar DEMO coil was built under industrial conditions, to be tested in the background field of the EU-LCT coil at the Forschungszentrum Karlsruhe (FZK). This paper reports the final manufacturing results and data from the warm acceptance test, as well as cryogenic data from strandmeasurements. (author)

  18. Magnetic mirror structure for testing shell-type quadrupole coils

    Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, F.; Novitski, I.; Tartaglia, N.; Turrioni, D.; /Fermilab


    This paper presents magnetic and mechanical designs and analyses of the quadrupole mirror structure to test single shell-type quadrupole coils. Several quadrupole coils made of different Nb{sub 3}Sn strands, cable insulation and pole materials were tested using this structure at 4.5 and 1.9 K. The coils were instrumented with voltage taps, spot heaters, temperature sensors and strain gauges to study their mechanical and thermal properties and quench performance. The results of the quadrupole mirror model assembly and test are reported and discussed.

  19. Magnetic mirror structure for testing shell-type quadrupole coils

    Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, F.; Novitski, I.; Tartaglia, N.; Turrioni, D.; /Fermilab


    This paper presents magnetic and mechanical designs and analyses of the quadrupole mirror structure to test single shell-type quadrupole coils. Several quadrupole coils made of different Nb{sub 3}Sn strands, cable insulation and pole materials were tested using this structure at 4.5 and 1.9 K. The coils were instrumented with voltage taps, spot heaters, temperature sensors and strain gauges to study their mechanical and thermal properties and quench performance. The results of the quadrupole mirror model assembly and test are reported and discussed.

  20. Parametric design of tri-axial nested Helmholtz coils.

    Abbott, Jake J


    This paper provides an optimal parametric design for tri-axial nested Helmholtz coils, which are used to generate a uniform magnetic field with controllable magnitude and direction. Circular and square coils, both with square cross section, are considered. Practical considerations such as wire selection, wire-wrapping efficiency, wire bending radius, choice of power supply, and inductance and time response are included. Using the equations provided, a designer can quickly create an optimal set of custom coils to generate a specified field magnitude in the uniform-field region while maintaining specified accessibility to the central workspace. An example case study is included.

  1. Intelligent shell feedback control in EXTRAP T2R reversed field pinch with partial coverage of the toroidal surface by a discrete active coil array

    Yadikin, D.; Brunsell, P. R.; Drake, J. R.


    An active feedback system is required for long pulse operation of the reversed field pinch (RFP) device to suppress resistive wall modes (RWMs). A general feature of a feedback system using a discrete active coil array is a coupling effect which arises when a set of side band modes determined by the number of active coils is produced. Recent results obtained on the EXTRAP T2R RFP demonstrated the suppression of independent m = 1 RWMs using an active feedback system with a two-dimensional array of discrete active coils in the poloidal and toroidal directions. One of the feedback algorithms used is the intelligent shell feedback scheme. Active feedback systems having different number of active coils in the poloidal (Mc) and toroidal (Nc) directions (Mc × Nc = 2 × 32 and Mc × Nc = 4 × 16) are studied. Different side band effects are seen for these configurations. A significant prolongation of the plasma discharge is achieved for the intelligent shell feedback scheme using the 2 × 32 active coil configuration. This is attributed to the side band sets including only one of the dominant unstable RWMs and avoiding coupling to resonant modes. Analog proportional-integral-derivative controllers are used in the feedback system. Regimes with different values of the proportional gain are studied. The requirement of the proportional-integral control for low proportional gain and proportional-derivative control for high proportional gain is seen in the experiments.

  2. A transition from strong right-handed to canonical left-handed supercoiling in a conserved coiled-coil segment of trimeric autotransporter adhesins.

    Alvarez, Birte Hernandez; Gruber, Markus; Ursinus, Astrid; Dunin-Horkawicz, Stanislaw; Lupas, Andrei N; Zeth, Kornelius


    Trimeric autotransporter adhesins (TAAs) represent an important class of pathogenicity factors in proteobacteria. Their defining feature is a conserved membrane anchor, which forms a 12-stranded beta-barrel through the outer membrane. The proteins are translocated through the pore of this barrel and, once export is complete, the pore is occluded by a three-stranded coiled coil with canonical heptad (7/2) sequence periodicity. In many TAAs this coiled coil is extended by a segment of varying length, which has pentadecad (15/4) periodicity. We used X-ray crystallography and biochemical methods to analyze the transition between these two periodicities in the coiled-coil stalk of the Yersinia adhesin YadA. Our results show how the strong right-handed supercoil of the 15/4-periodic part locally undergoes further over-winding to 19/5, before switching at a fairly constant rate over 14 residues to the canonical left-handed supercoil of the 7/2-periodic part. The transition region contains two YxD motifs, which are characteristic for right-handed coiled-coil segments of TAAs. This novel coiled-coil motif forms a defined network of inter- and intrahelical hydrogen bonds, thus serving as a structural determinant. Supercoil fluctuations have hitherto been described in coiled coils whose main sequence periodicity is disrupted locally by discontinuities. Here we present the first detailed analysis of two fundamentally different coiled-coil periodicities being accommodated in the same structure.

  3. The Role of Filtration in Maintaining Clean Heat Exchanger Coils

    Li Yang; James E. Braun; Eckhard A. Groll


    The main purpose of the study was to investigate the role of filtration in maintaining clean heat exchanger coils and overall performance. Combinations of 6 different levels of filtration (MERV 14, 11, 8, 6, 4, and no filter) and 4 different coils (an eight-row lanced-fin coil, HX8L), (an eight-row wavy-fin coil, HX8W), (a four-row lanced-fin coil, HX4L) and (a two-row lanced-fin coil, HX2L) were tested at 4 different air velocities (1.52, 2.03, 2.54,3.05 m/s (300, 400, 500, 600 ft/min)). The fouled conditions were obtained after injection of 600 grams of ASHRAE standard dust upstream of the filter/coil combination. This magnitude of dust is representative of a year of normal operation for an air conditioning system. The air-side pressure drops of the coils and filters and air-side heat transfer coefficients of the coils were determined from the measurements under the clean and fouled conditions. Depending upon the filter and coil test, the coil pressure drops increased in the range of 6%-30% for an air velocity at 2.54 m/s (500 ft/min). The impact was significantly greater for tests performed without a filter. The largest relative effect of fouling on pressure drop occurs for coils with fewer rows and having lanced fins. Coils with a greater number of rows can hold more dust so that a fixed amount of dust has a relatively smaller impact. The impact of fouling on air-side heat transfer coefficients was found to be relatively small. In some cases, heat transfer was actually enhanced due to additional turbulence caused by the presence of dust. The experimental results for pressure drops and heat transfer coefficients were correlated and the correlations were implemented within computer models of prototypical rooftop air conditioners and used to evaluate the impact of fouling on cooling capacity and EER. The equipment cooling capacity is reduced with fouling primarily because of a decrease in air flow due to the increase pressure drop rather than due to changes in h

  4. Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella

    E. Lesne


    Full Text Available The two-component system BvgAS controls the expression of the virulence regulon of Bordetella pertussis. BvgS is a prototype of bacterial sensor kinases with extracytoplasmic Venus flytrap perception domains. Following its transmembrane segment, BvgS harbors a cytoplasmic Per-Arnt-Sim (PAS domain and then a predicted 2-helix coiled coil that precede the dimerization-histidine-phosphotransfer domain of the kinase. BvgS homologs have a similar domain organization, or they harbor only a predicted coiled coil between the transmembrane and the dimerization-histidine-phosphotransfer domains. Here, we show that the 2-helix coiled coil of BvgS regulates the enzymatic activity in a mechanical manner. Its marginally stable hydrophobic interface enables a switch between a state of great rotational dynamics in the kinase mode and a more rigid conformation in the phosphatase mode in response to signal perception by the periplasmic domains. We further show that the activity of BvgS is controlled in the same manner if its PAS domain is replaced with the natural α-helical sequences of PAS-less homologs. Clamshell motions of the Venus flytrap domains trigger the shift of the coiled coil’s dynamics. Thus, we have uncovered a general mechanism of regulation for the BvgS family of Venus flytrap-containing two-component sensor kinases.

  5. The significant impact of framing coils on long-term outcomes in endovascular coiling for intracranial aneurysms: how to select an appropriate framing coil.

    Ishida, Wataru; Sato, Masayuki; Amano, Tatsuo; Matsumaru, Yuji


    OBJECTIVE The importance of a framing coil (FC)-the first coil inserted into an aneurysm during endovascular coiling, also called a lead coil or a first coil-is recognized, but its impact on long-term outcomes, including recanalization and retreatment, is not well established. The purposes of this study were to test the hypothesis that the FC is a significant factor for aneurysmal recurrence and to provide some insights on appropriate FC selection. METHODS The authors retrospectively reviewed endovascular coiling for 280 unruptured intracranial aneurysms and gathered data on age, sex, aneurysm location, aneurysm morphology, maximal size, neck width, adjunctive techniques, recanalization, retreatment, follow-up periods, total volume packing density (VPD), volume packing density of the FC, and framing coil percentage (FCP; the percentage of FC volume in total coil volume) to clarify the associated factors for aneurysmal recurrence. RESULTS Of 236 aneurysms included in this study, 33 (14.0%) had recanalization, and 18 (7.6%) needed retreatment during a mean follow-up period of 37.7 ± 16.1 months. In multivariate analysis, aneurysm size (odds ratio [OR] = 1.29, p < 0.001), FCP < 32% (OR 3.54, p = 0.009), and VPD < 25% (OR 2.96, p = 0.015) were significantly associated with recanalization, while aneurysm size (OR 1.25, p < 0.001) and FCP < 32% (OR 6.91, p = 0.017) were significant predictors of retreatment. VPD as a continuous value or VPD with any cutoff value could not predict retreatment with statistical significance in multivariate analysis. CONCLUSIONS FCP, which is equal to the FC volume as a percentage of the total coil volume and is unaffected by the morphology of the aneurysm or the measurement error in aneurysm length, width, or height, is a novel predictor of recanalization and retreatment and is more significantly predictive of retreatment than VPD. To select FCs large enough to meet the condition of FCP ≥ 32% is a potential relevant factor for better

  6. Inductively coupled transducer system for damage detection in composites

    Zhong, C. H.; Croxford, A. J.; Wilcox, P. D.


    The laminated construction of composite offers the possibility of permanently embedding sensors into structure, for example, ultrasonic transducers which can be used for NDE applications. An attractive and simple solution for probing embedded sensors wirelessly is via inductive coupling. However, before this can be achieved it is necessary to have a full understanding and proper design strategy for the inductively coupled system. This paper presents the developments of both system design procedure and a computer program for one dimensional inductively coupled transducer system mounted on a solid substrate. The design strategy in this paper mainly focuses on issues of localization of transducers, and optimizing the signal to noise level. Starting from a three coil equivalent circuit, this paper also explains how the measured impedance of a bonded piezoelectric disc is implemented into the system model representing a transducer bonded to an arbitrary solid substrate. The computer programme using this model provides immediate predictions of electrical input impedance, acoustic response and pulse-echo response. A series of experiments and calculations have been performed in order to validate the model. This has enabled the degree of accuracy required for various parameters within the model, such as mutual inductance between the coils and self-inductance of coils, to be assessed. Once validated, the model can be used as a tool to predict the effect of physical parameters, such as distance, lateral misalignment between the coils, and the coil geometry on the performance of an inductively coupled system.

  7. Formation of current coils in geodynamo simulations.

    Kageyama, Akira; Miyagoshi, Takehiro; Sato, Tetsuya


    Computer simulations have been playing an important role in the development of our understanding of the geodynamo, but direct numerical simulation of the geodynamo with a realistic parameter regime is still beyond the power of today's supercomputers. Difficulties in simulating the geodynamo arise from the extreme conditions of the core, which are characterized by very large or very small values of the non-dimensional parameters of the system. Among them, the Ekman number, E, has been adopted as a barometer of the distance of simulations from real core conditions, in which E is of the order of 10(-15). Following the initial computer simulations of the geodynamo, the Ekman number achieved has been steadily decreasing, with recent geodynamo simulations performed with E of the order of 10(-6). Here we present a geodynamo simulation with an Ekman number of the order of 10(-7)-the highest-resolution simulation yet achieved, making use of 4,096 processors of the Earth Simulator. We have found that both the convection flow and magnetic field structures are qualitatively different from those found in larger-Ekman-number dynamos. The convection takes the form of sheet plumes or radial sheet jets, rather than the columnar cell structures that are usually found. We have found that this sheet plume convection is an effective dynamo and the generated current is organized as a set of coils in the shape of helical springs or at times as a torus.

  8. The Search-Coil Magnetometer for MMS

    Le Contel, O.; Leroy, P.; Roux, A.; Coillot, C.; Alison, D.; Bouabdellah, A.; Mirioni, L.; Meslier, L.; Galic, A.; Vassal, M. C.; Torbert, R. B.; Needell, J.; Rau, D.; Dors, I.; Ergun, R. E.; Westfall, J.; Summers, D.; Wallace, J.; Magnes, W.; Valavanoglou, A.; Olsson, G.; Chutter, M.; Macri, J.; Myers, S.; Turco, S.; Nolin, J.; Bodet, D.; Rowe, K.; Tanguy, M.; de la Porte, B.


    The tri-axial search-coil magnetometer (SCM) belongs to the FIELDS instrumentation suite on the Magnetospheric Multiscale (MMS) mission (Torbert et al. in Space Sci. Rev. (2014), this issue). It provides the three magnetic components of the waves from 1 Hz to 6 kHz in particular in the key regions of the Earth's magnetosphere namely the subsolar region and the magnetotail. Magnetospheric plasmas being collisionless, such a measurement is crucial as the electromagnetic waves are thought to provide a way to ensure the conversion from magnetic to thermal and kinetic energies allowing local or global reconfigurations of the Earth's magnetic field. The analog waveforms provided by the SCM are digitized and processed inside the digital signal processor (DSP), within the Central Electronics Box (CEB), together with the electric field data provided by the spin-plane double probe (SDP) and the axial double probe (ADP). On-board calibration signal provided by DSP allows the verification of the SCM transfer function once per orbit. Magnetic waveforms and on-board spectra computed by DSP are available at different time resolution depending on the selected mode. The SCM design is described in details as well as the different steps of the ground and in-flight calibrations.

  9. Coil-Type Asymmetric Supercapacitor Electrical Cables.

    Yu, Zenan; Moore, Julian; Calderon, Jean; Zhai, Lei; Thomas, Jayan


    Cable-shaped supercapacitors (SCs) have recently aroused significant attention due to their attractive properties such as small size, lightweight, and bendability. Current cable-shaped SCs have symmetric device configuration. However, if an asymmetric design is used in cable-shaped supercapacitors, they would become more attractive due to broader cell operation voltages, which results in higher energy densities. Here, a novel coil-type asymmetric supercapacitor electrical cable (CASEC) is reported with enhanced cell operation voltage and extraordinary mechanical-electrochemical stability. The CASECs show excellent charge-discharge profiles, extraordinary rate capability (95.4%), high energy density (0.85 mWh cm(-3)), remarkable flexibility and bendability, and superior bending cycle stability (≈93.0% after 4000 cycles at different bending states). In addition, the CASECs not only exhibit the capability to store energy but also to transmit electricity simultaneously and independently. The integrated electrical conduction and storage capability of CASECS offer many potential applications in solar energy storage and electronic gadgets. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. ITER coils insulation R and D program

    Vieira, R.F.; Sugimoto, M.; Osaki, O.; Fujioka, T.; Korsunsky, V.; Reed, R.P.; Katheder, H.; Broadbent, A.


    The ITER coil insulation systems are required for operating voltages up to 10 KV and to support shear and normal compression loads through the winding pack. Manufacturing considerations and nuclear radiation resistance also influence the choice of suitable systems. A screening program of candidate systems is being conducted in stages. The first stage is reported in this paper. Present R and D data based on small samples indicate a static shear strength of about 85 MPa for a glass or alumina and epoxy resin vacuum pressure impregnation system and 50 MPa for a pre-impregnated glass/epoxy resin system with polyimide interleaved at a temperature of 4K. The preliminary irradiation results show that coating the steel surface with inorganic materials such as Al{sub 2}O{sub 3} or ZrO{sub 2}/8 Y{sub 2}O{sub 3} is beneficial in increasing the radiation resistance as far as shear strength is concerned. In addition Tetrafunctional epoxy (TGDM) systems appear to be more radiation resistant than Diglycidyl Ether of Bisphenol-A (DGEBA) systems. Further R and D work will focus on prototypical samples to continue evaluation of the performance of the insulation systems.

  11. Revisiting Coiled Flocculator Performance for Particle Aggregation.


    This work summarizes recent studies evaluating the torsion and curvature parameters in the flocculation efficiency using a hydraulic plug-flow flocculator named as Flocs Generator Reactor (FGR). Colloidal Fe(OH)3 and coal particles were used as suspension models and a cationic polyacrylamide was used for the flocculation. The effectiveness of the aggregation process (in the distinct curvature and torsion parameters and hydrodynamic conditions) was evaluated by the settling rate of the Fe(OH)3 flocs and flocs size by photographic analysis. Due to curvature, a secondary flow is induced and the profiles of the flow quantities differ from those for a straight pipe. Results showed that the difference in the flocculator design influences the Fe(OH)3 flocs size and settling rates, reaching values about 13 and 4 mh-1, for the coiled and straight pipes respectively. Coal flocs generation also showed to be dependent on the flocculator design and shear rate. Results showed that turbulent kinetic energy increases due to curvature when the torsion parameter is kept constant (pitch close to zero) enhancing the flocs formation.

  12. Implementation of a planar coil of wires as a sinus-galvanometer. Analysis of the coil magnetic field

    Stoyanov, Dimitar G


    The paper presents a theoretical analysis on the interaction between the Earth's magnetic field of a compass needle and the magnetic field of a straight infinite current-carrying wire. Implementation of a planar horizontal coil of wires has been shown as a sinus galvanometer. The magnetic field over the planar coil of wires has been examined by experiment. The coil could be used as a model for straight infinite current wire in demonstration set-ups or could be given as an assignment in Physics laboratory workshops.

  13. Implementation of a planar coil of wires as a sinus-galvanometer. Analysis of the coil magnetic field

    Stoyanov, Dimitar G.


    The paper presents a theoretical analysis on the interaction between the Earth's magnetic field of a compass needle and the magnetic field of a straight infinite current-carrying wire. Implementation of a planar horizontal coil of wires has been shown as a sinus galvanometer. The magnetic field over the planar coil of wires has been examined by experiment. The coil could be used as a model for straight infinite current wire in demonstration set-ups or could be given as an assignment in Physic...

  14. Novel Coil Winding Method to Realize Pot Heated Evenly

    Mao-Yan Wang; Hai-Long Li; Meng Zhang; Zhi-Tao Xu; Cui-Lin Zhong; Jun Xu


    To solve the problem about the inhomogeneous thermal effect of pot heated by coils along the circumference, a novel coil winding method is proposed and compared with the general winding method in the paper. First, based on the Biot-Savart law and Ampere’s rule, the magnetic induction generated by a straight current carrying conductor and a current loop is discussed, respectively. Then the novel coil winding method is developed by adjusting the location of inhomogeneous joints. The joints are periodically scattered along the circumferential direction and symmetrically designed around the central axis. Numerical results show that the quite non-uniform temperature in the base of pot at the circular direction is effectively improved by using the proposed winding method. The potential danger produced by high temperature at some region of coils plate is minimized. It is energy-efficient and safe for residential appliances.

  15. High-quality Critical Heat Flux in Horizontally Coiled Tubes


    An investigation on the high-quality dryout in two electrically heated coiled tubes with horizontally helix axes is reported.The temperature profiles both along the tube and around the circumference are measured.and it is found that the temperature profiles around the circumference are not identical for the corss-sections at different parts of the coil.The “local condition hypothesis” seems applicable under present conditions,and the critical heat flux qcr decreases with increasing critical quality xcr.The CHF increases as mass velocity and ratio of tube diameter to coil diameter(d/D) increases,and it seems not to be affected hby the system pressure.The CHF is larger with coils than that with straight tubes,and the difference increases with increasing mass velocity and d/D.

  16. Characterization of coiled SMA actuators for humanoid robot

    Potnuru, Akshay; Tadesse, Yonas


    In this paper, we present modeling and characterization of coiled SMA spring actuators that are fabricated by coiling cylindrical SMA wires on to a threaded screw mandrel and applying heat treatment. Here, we evaluate a theoretical model that describes the actuation behavior of SMA coiled springs based on the constitutive model of SMA. We have experimentally verified the developed theoretical model and analyzed various parameters with respect to temperature change during actuation. The model was coded in Simulink® and the effects of various parameters with respect to temperature change were investigated. Simulations were compared with experiments and good agreement was obtained. We also show, how the high tension winding of SMA on the mandrel help in better performance and understanding of the fabricated coiled SMAs.

  17. Coiled Brine Recovery Assembly (CoBRA) Project

    National Aeronautics and Space Administration — The Coiled Brine Recovery Assembly (CoBRA) project will result in a proof-of-concept demonstration for a lightweight, compact, affordable, regenerable and disposable...

  18. Critical Current Measurements in Commercial Tapes, Coils, and Magnets.

    Gubser, D. U.; Soulen, R. J., Jr.; Fuller-Mora, W. W.; Francavilla, T. L.


    We have measured a number of tapes, coils, and magnets produced by commercial vendors and determined their properties as functions of magnetic field and temperature. The tapes were measured at the National High Magnetic Field Laboratory in magnetic fields to 20 tesla and at temperatures of 4.2 K, 27 K, 65 K, and 77 K. For the tapes we report critical currents and current-voltage characteristics. Six inch diameter coils were measured at NRL in zero magnetic field. Critical currents, current-voltage characteristics, and reliability studies are reported for the coils. Larger 10 inch diameter coils, which are to be used in a 200 hp superconducting motor, were also measured and results will be presented. The talk will also review the status of the most recent tests of the superconducting motor.

  19. Foldable micro coils for a transponder system measuring intraocular pressure

    Ullerich, S.; Schnakenberg, U. [Technische Hochschule Aachen (Germany). Inst. of Materials in Electrical Engineering 1; Mokwa, W. [Technische Hochschule Aachen (Germany). Inst. of Materials in Electrical Engineering 1]|[Fraunhofer Inst. of Microelectronic Circuits and Systems, Duisburg (Germany); Boegel, G. vom [Fraunhofer Inst. of Microelectronic Circuits and Systems, Duisburg (Germany)


    A foldable transponder system consisting of a chip and a micro coil for measuring intraocular pressure continuously is presented. The system will be integrated in the haptic of a soft artificial intraocular lens. Calculations of planar micro coils with 6 mm and 10.3 mm in diameter show the limits for planar coils with an outer diameter of 6 mm. For the realisation of the transponder system a 20 {mu}m thick coil with an outer diameter of 10.3 mm, an inner diameter of 7.7 mm, 16 turns and a gap of 20 {mu}m between the windings was selected. Measurements show a good agreement between calculated and measured values. Wireless pressure measurements were carried out showing a linear behaviour of the output signal with respect to the applied pressure. (orig.)

  20. Photonic crystal fiber coil sensor for water-depth sensing

    Fan, Chen-Feng; Yu, Chin-Ping


    We fabricate a PCF coil sensor for water-depth sensing by winding a PCF on a plastic straw. Due to the bending-induced birefringence along the PCF, we can observe clear interference pattern in the output spectrum by placing the PCF coil into a Sagnac fiber loop. As we horizontally immerse the fabricated PCF coil into water, a nonlinear relationship between the water depth and the wavelength shift can be obtained. We have also measured the interference spectrum by vertically immersing the PCF coil into water. We can observe a linear relationship between the water depth and the wavelength shift, and the measured water-depth sensitivity for vertical immersion is -1.17 nm/mm.

  1. Experiment of low resistance joints for the ITER correction coil.

    Liu, Huajun; Wu, Yu; Wu, Weiyue; Liu, Bo; Shi, Yi; Guo, Shuai


    A test method was designed and performed to measure joint resistance of the ITER correction coil (CC) in liquid helium (LHe) temperature. A 10 kA superconducting transformer was manufactured to provide the joints current. The transformer consisted of two concentric layer-wound superconducting solenoids. NbTi superconducting wire was wound in the primary coil and the ITER CC conductor was wound in the secondary coil. The primary and the secondary coils were both immersed in liquid helium of a 300 mm useful bore diameter cryostat. Two ITER CC joints were assembled in the secondary loop and tested. The current of the secondary loop was ramped to 9 kA in several steps. The two joint resistances were measured to be 1.2 nΩ and 1.65 nΩ, respectively.

  2. Rapid mixing of viscous liquids by electrical coiling

    Kong, Tiantian; Li, Jingmei; Liu, Zhou; Zhou, Zhuolong; Ng, Peter Hon Yu; Wang, Liqiu; Shum, Ho Cheung


    The control for the processing of precursor liquids determines whether the properties and functions of the final material product can be engineered. An inherent challenge of processing viscous liquids arises from their large resistance to deform. Here, we report on the discovery of an electric approach that can significantly contribute to address this challenge. The applied electric force can induce a straight viscous jet to coil, and the resulting coiling characteristics are governed by the electric stress. We demonstrate the promising use of electrical coiling in the rapid and efficient mixing of viscous liquids. Remarkably, the degree of mixing can be precisely adjusted by tuning the applied electric stress. Our approach of controlling the coiling electrically has important implications on applications such as dispensing and printing of resins, printing patterned surfaces and scaffolds, processing of food and generating non-woven fabrics.

  3. Test data from the US-Demonstration Poloidal Coil experiment

    Painter, T.A.; Steeves, M.M.; Takayasu, M.; Gung, C.; Hoenig, M.O. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Plasma Fusion Center; Tsuji, H.; Ando, T.; Hiyama, T.; Takahashi, Y.; Nishi, M.; Yoshida, K.; Okuno, K.; Nakajima, H.; Kato, T.; Sugimoto, M.; Isono, T.; Kawano, K.; Koizumi, N.; Osikiri, M.; Hanawa, H.; Ouchi, H.; Ono, M.; Ishida, H.; Hiue, H.; Yoshida, J.; Kamiyauchi, Y.; Ouchi, T.; Tajiri, F.; Kon, Y.; Shimizu, H.; Matsuzaki, Y.; Oomori, S.; Tani, T.; Oomori, K.; Terakado, T.; Yagyu, J.; Oomori, H. [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Superconducting Magnet Lab.


    The US Demonstration Poloidal Field Coil (US-DPC) experiment took place successfully at the Japan Atomic Energy Research Institute (JAERI) in late 1990. The 8 MJ niobium-tin coil was leak tight; it performed very well in DC tests; it performed well in AC tests, achieving approximately 70% of its design goal. An unexpected ramp-rate barrier at high currents was identified. The barrier could not be explored in the regime of higher fields and slower ramp rates due to limitations of the background-field coils. This document presents the results of the experiment with as little editing as possible. The coil, conductor, and operating conditions are given. The intent is to present data in a form that can be used by magnet analysts and designers.

  4. Convective heat transfer enhancement inside tubes using inserted helical coils

    Ali, R. K.; Sharafeldeen, M. A.; Berbish, N. S.; Moawed, M. A.


    Convective heat transfer was experimentally investigated in tubes with helical coils inserts in turbulent flow regime within Reynolds number range of 14400 ≤ Re ≤ 42900. The present work aims to extend the experimental data available on wire coil inserts to cover wire diameter ratio from 0.044 to 0.133 and coil pitch ratio from 1 to 5. Uniform heat flux was applied to the external surface of the tube and air was selected as fluid. The effects of Reynolds number and wire diameter and coil pitch ratios on the Nusselt number and friction factor were studied. The enhancement efficiency and performance criteria ranges are of (46.9-82.6%) and (100.1-128%) within the investigated range of the different parameters, respectively. Correlations are obtained for the average Nusselt number and friction factor utilizing the present measurements within the investigated range of geometrical parameters and Re.

  5. Progress of the ITER Correction Coils in China

    Wei, J; Han, S; Yu, X; Du, S; Li, C; Fang, C; Wang, L; Zheng, W; Liu, L; Wen, J; Li, H; Libeyre, P; Dolgetta, N; Cormany, C; Sgobba, S


    The ITER Correction Coils (CC) include three sets of six coils each, distributed symmetrically around the tokamak to correct error fields. Each pair of coils, located on opposite sides of the tokamak, is series connected with polarity to produce asymmetric fields. The manufacturing of these superconducting coils is undergoing qualification of the main fabrication processes: winding into multiple pancakes, welding helium inlet/outlet on the conductor jacket, turn and ground insulation, vacuum pressure impregnation, inserting into an austenitic stainless steel case, enclosure welding, and assembling the terminal service box. It has been proceeding by an intense phase of R\\&D, trials tests, and final adjustment of the tooling. This paper mainly describes the progress in ASIPP for the CC manufacturing process before and on qualification phase and the status of corresponding equipment which are ordered or designed for each process. Some test results for the key component and procedure are also presented.

  6. Experimental evaluation of helically coiled tube flocculators for ...

    Experimental evaluation of helically coiled tube flocculators for turbidity removal ... clarification system, while varying hydraulic and geometrical parameters in HCTs. ... of baffled tank processing times) were observed for high efficiency process ...

  7. A hybrid optimization method for biplanar transverse gradient coil design

    Qi Feng [Key Laboratory for Quantum Information and Measurements, Ministry of Education, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871 (China); Tang Xin [Beijing Key Laboratory of Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871 (China); Jin Zhe [Key Laboratory for Quantum Information and Measurements, Ministry of Education, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871 (China); Jiang Zhongde [Beijing Key Laboratory of Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871 (China); Shen Yifei [Key Laboratory for Quantum Information and Measurements, Ministry of Education, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871 (China); Meng Bin [Key Laboratory for Quantum Information and Measurements, Ministry of Education, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871 (China); Zu Donglin [Beijing Key Laboratory of Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871 (China); Wang Weimin [Key Laboratory for Quantum Information and Measurements, Ministry of Education, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871 (China)


    The optimization of transverse gradient coils is one of the fundamental problems in designing magnetic resonance imaging gradient systems. A new approach is presented in this paper to optimize the transverse gradient coils' performance. First, in the traditional spherical harmonic target field method, high order coefficients, which are commonly ignored, are used in the first stage of the optimization process to give better homogeneity. Then, some cosine terms are introduced into the series expansion of stream function. These new terms provide simulated annealing optimization with new freedoms. Comparison between the traditional method and the optimized method shows that the inhomogeneity in the region of interest can be reduced from 5.03% to 1.39%, the coil efficiency increased from 3.83 to 6.31 mT m{sup -1} A{sup -1} and the minimum distance of these discrete coils raised from 1.54 to 3.16 mm.

  8. Modelling and Practical Implementation of 2-Coil Wireless Power Transfer Systems

    Hong Zhou


    Full Text Available Wireless power transfer (WPT based on inductive coupling could be potentially applied in many practical applications. It has attracted a lot of research interests in the last few years. In this paper, the modelling, design, and implementation of a 2-coil WPT system are represented. The prototype system can be implemented using conventional power electronic devices such as MOSFETs with very low costs as it works in relative low frequency range (less than 1 MHz. In order to find out about the optimal working area for the WPT system, the circuit model based on the practical parameters from the prototype is built. The relationships between the exciting frequency, coupling, and output power are analyzed based on the circuit and magnetic principles. Apart from the theoretic study, the detailed implementation of the WPT prototype including the coil design, digital frequency generation, and high frequency power electronics is also introduced in this paper. Experiments are conducted to verify the effectiveness of the circuit analysis. By carefully tuning the circuit parameters, the prototype is able to deliver 20 W power through 2.2 meter distance with 20–30% efficiency.

  9. NSTX-U Digital Coil Protection System Software Detailed Design



    The National Spherical Torus Experiment (NSTX) currently uses a collection of analog signal processing solutions for coil protection. Part of the NSTX Upgrade (NSTX-U) entails replacing these analog systems with a software solution running on a conventional computing platform. The new Digital Coil Protection System (DCPS) will replace the old systems entirely, while also providing an extensible framework that allows adding new functionality as desired.

  10. Development and testing of the cooling coil cleaning end effector

    Johnson, K.I.; Mullen, O.D.; Powell, M.R.; Daly, D.S.; Engel, D.W.


    The Retrieval Process Development and Enhancement (KPD{ampersand}E) program has developed and tested an end effector to support the waste retrieval mission at the Idaho National Engineering and Environmental Laboratory (INEEL). The end effector was developed specifically to remove a sticky waste material from the cooling coils in the High Level Liquid Waste (HLLW) tank, and to vacuum up a sediment layer that has settled beneath the cooling coils. An extensive testing program was conducted in the hydraulic test bed (HTB) at the Pacific Northwest National Laboratory (PNNL) to evaluate the performance of the end effector under simulated in-tank conditions. A mock up of the cooling coils was installed in the test bed tank, and simulated waste materials were included to represent the sticky waste on the tubes and the particulate waste settled beneath them. The testing program focused on assessing long-duration mining strategies for cleaning the cooling coils and removing the particulate waste forms. The report describes the results of the end effector testing program at PNNL. Section 2 describes the physical characteristics of the HLLW tanks, including the layout of the cooling coils, and it also describes what is known of the waste forms in the tanks. Section 3 describes the cleaning and retrieval strategy that was used in developing the end effector design. Section 4 describes the cooling coil mockup in the hydraulic test bed. Section 5 discusses the rationale used in selecting the simulants for the tarry waste and particulate waste forms. Section 6 describes the tests that were performed to evaluate cleaning of the cooling coils and retrieval of the particulate simulant. Section 7 summarizes the cleaning and retrieval tests, assesses the relative importance of cleaning the cooling coils and retrieving the particulate waste, and suggests modifications that would simplify the end effector design.

  11. Treatment of pulmonary arteriovenous malformation using platinum coils: case report

    Kim, Man Deuk; Kim, Jeung Sook; Lim, Chang Young [College of Medicine, Pochon CHA University, Pochon (China)


    Pulmonary arteriovenous malformation (PAVM) is an abnormal direct communication between the pulmonary arteries and veins without any capillary network. The patients may be completely asymptomatic or may they develop serious complications including hemoptysis and brain abscess. We present here a case of incidentally found PAVM in a 33-year-old male who underwent embolization using platinum coils. Coil embolization is a safe, highly effective procedure that should be considered more often for the treatment of PAVM.

  12. High-Q Antennas with built-in coils

    Bahramzy, Pevand; Svendsen, Simon; Pedersen, Gert Frølund


    Efficiency and isolation, at low frequencies (700 MHz), are two of the most important metrics for successful multicommunication implementation. This paper presents an antenna concept, that exhibits a very high isolation between high-Q Tx and Rx antennas at 700 MHz. Furthermore, it is shown how...... coils can be integrating into the antenna structure for obtaining better efficiency. It is shown that by integrated coils into the antenna structure, the efficiency can be improved by 2dB for each antenna....

  13. Support system for the W7-X coil assembly

    Jaksic, N.; Simon-Weidner, J.; Sapper, J. [Max-Planck-Institut fuer Plasmaphysik, Garching (Germany)


    The WENDELSTEIN 7-X (W7-X) stellarator experiment is now in the state of its final design. The basic confinement system consists of 50 nonplanar and 20 planar superconducting coils. Meanwhile the geometrical data of the coils have been fixed. The changes with respect to the first design influenced the support concept taking into account needs on enlarged space for the different ports and nozzles. (author)

  14. How long does it take to coil an intracranial aneurysm?

    Gast, Anjob N. de; Soepboer, Aelwyn; Sluzewski, Menno; Rooij, Willem J. van [St. Elisabeth Ziekenhuis, Department of Radiology, Tilburg (Netherlands); Beute, Guus N. [St. Elisabeth Ziekenhuis, Department of Neurosurgery, Tilburg (Netherlands)


    The change in the treatment of choice for intracranial aneurysms from clipping to coiling has been associated with an important change in logistics. The time needed for coiling is variable and depends on many factors. In this study, we assessed the procedural time for the coiling of 642 aneurysms and tried to identify predictors of a long procedural time. The procedural time for coiling was defined as the number of minutes between the first diagnostic angiographic run and the last angiographic run after embolization. Thus, induction of general anesthesia and catheterization of the first vessel were not included in the procedural time. A long procedural time was defined as the upper quartile of procedural times (70-158 min). Logistic regression analysis was performed for several variables. The mean procedural time was 57.3 min (median 52 min, range 15-158 min). More than half of the coiling procedures lasted between 30 and 60 min. Multiple logistic regression analysis identified the use of a supportive device (OR 5.4), procedural morbidity (OR 4.5) and large aneurysm size (OR 3.0) as independent predictors of a long procedural time. A poor clinical condition of the patient, the rupture status of the aneurysm, gender, the occurrence of procedural rupture, and aneurysm location were not related to a long procedural time. The mean time for the first 321 coiling procedures was not statistically significantly different from mean time for the last 321 procedures. With optimal logistics, coiling of most intracranial aneurysms can be performed in one to two hours, including patient handling before and after the actual coiling procedure. (orig.)

  15. Design of an MgB2 race track coil for a wind generator pole demonstration

    Abrahamsen, A.B.; Magnusson, N.; Jensen, B.B.; Liu, D.; Polinder, H.


    An MgB2 race track coil intended for demonstrating a down scaled pole of a 10 MW direct drive wind turbine generator has been designed. The coil consists of 10 double pancake coils stacked into a race track coil with a cross section of 84 mm x 80 mm. The length of the straight section is 0.5 m and t

  16. Design of an MgB2 race track coil for a wind generator pole demonstration

    Abrahamsen, A.B.; Magnusson, N.; Jensen, B.B.; Liu, D.; Polinder, H.


    An MgB2 race track coil intended for demonstrating a down scaled pole of a 10 MW direct drive wind turbine generator has been designed. The coil consists of 10 double pancake coils stacked into a race track coil with a cross section of 84 mm x 80 mm. The length of the straight section is 0.5 m and

  17. Retrieval of a Migrated Coil Using an X6 MERCI Device.

    O'Hare, A


    Summary: Coil migration is a recognised but rare complication of endovascular coiling. Many techniques are available commercially for coil retrieval. We report the case of an acute subarachnoid hemorrhage in a 54-year-old woman in which a migrated coil was successfully retrieved using an X6 MERCI device.

  18. The Effect of Axial Stress on YBCO Coils

    Sampson, W.; Anerella, M.; Cozzolino, J.P.; Gupta, R.C.; Shiroyanagi, Y.; Evangelou, E.


    The large aspect ratio of typical YBCO conductors makes them ideal for constructing solenoids from pancake style coils. An advantage of this method is that each subunit can be tested before assembly into the finished magnet. The fact that conductors are available in relatively short lengths is another reason for using such a fabrication technique. The principal drawback is the large number of joints required to connect the coils together. When very high field solenoids such as those contemplated for the muon collider are built in this way the magnetic forces between pancakes can be very large. Extensive measurements have been made on the effect of stress on short lengths of conductor, but there is little or no data on the effect of intercoil loading. The experiment described in this paper was designed to test the ability of YBCO coils to withstand these forces. A spiral wound 'pancake' coil made from YBCO coated conductor has been stressed to a pressure of 100MPa in the axial direction at 77K. In this case axial refers to the coil so that the force is applied to the edge of the conductor. The effect on the critical current was small and completely reversible. Repeatedly cycling the pressure had no measureable permanent effect on the coil. The small current change observed exhibited a slight hysteretic behaviour during the loading cycle.

  19. Low Impedance Voice Coils for Improved Loudspeaker Efficiency

    Iversen, Niels Elkjær; Knott, Arnold; Andersen, Michael A. E.


    In modern audio systems utilizing switch-mode amplifiers the total efficiency is dominated by the rather poor efficiency of the loudspeaker. For decades voice coils have been designed so that nominal resistances of 4 to 8 Ohms is obtained, despite modern audio amplifiers, using switch-mode techno......In modern audio systems utilizing switch-mode amplifiers the total efficiency is dominated by the rather poor efficiency of the loudspeaker. For decades voice coils have been designed so that nominal resistances of 4 to 8 Ohms is obtained, despite modern audio amplifiers, using switch......-mode technology, can be designed to much lower loads. A thorough analysis of the loudspeaker efficiency is presented and its relation to the voice coil fill factor is described. A new parameter, the drivers mass ratio, is introduced and it indicates how much a fill factor optimization will improve a driver......’s efficiency. Different voice coil winding layouts are described and their fill factors analyzed. It is found that by lowering the nominal resistance of a voice coil, using rectangular wire, one can increase the fill factor. Three voice coils are designed for a standard 10” woofer and corresponding frequency...

  20. Effect of Metal Proximity on a Pulsed Copper Coil

    Johnson, H. K.; Schaffner, D. A.; Brown, M. R.; Kaur, M.; Fiedler-Kawaguchi, C.


    Generating and accelerating plasma in a stainless steel chamber affects the magnetic fields inside. These effects will decrease the field due to a pulsed coil (which will later be used to accelerate plasma) inside the chamber. This work is being done in conjunction with the Swarthmore Spheromak Experiment. Both facilities are collaborating in an attempt to accelerate and compress plasma as part of ARPA-E's Accelerating Low-Cost Plasma Heating and Assembly (ALPHA) program. Measurements of the impact of the chamber on the coil's magnetic fields were made using a B-dot probe inside the coil, which was placed at incremental distances from a metal plate. As the coil is moved from the plate, the plate's interference with the field was seen to exponentially decay. This process was repeated for stainless steel, aluminum, and copper, and a range of voltages (500-800V). At least seventy percent of the original signal was recovered within two inches. Pulsing the coil inside the stainless steel chamber resulted in signals about one third the strength of those measured outside of the chamber. The results of this experiment will be used to guide development of the stainless steel pulse-coil system for the Swarthmore ALPHA project. Work supported by ARPA-E ALPHA program.

  1. Automatic tuning of flexible interventional RF receiver coils.

    Venook, Ross D; Hargreaves, Brian A; Gold, Garry E; Conolly, Steven M; Scott, Greig C


    Microcontroller-based circuitry was built and tested for automatically tuning flexible RF receiver coils at the touch of a button. This circuitry is robust to 10% changes in probe center frequency, is in line with the scanner, and requires less than 1 s to tune a simple probe. Images were acquired using this circuitry with a varactor-tunable 1-inch flexible probe in a phantom and in an in vitro porcine knee model. The phantom experiments support the use of automatic tuning by demonstrating 30% signal-to-noise ratio (SNR) losses for 5% changes in coil center frequency, in agreement with theoretical calculations. Comparisons between patellofemoral cartilage images obtained using a 3-inch surface coil and the surgically-implanted 1-inch flexible coil reveal a worst-case local SNR advantage of a factor of 4 for the smaller coil. This work confirms that surgically implanted coils can greatly improve resolution in small-field-of-view (FOV) applications, and demonstrates the importance and feasibility of automatically tuning such probes.

  2. First ATLAS Barrel Toroid coil casing arrives at CERN


    The first of eight 25-metre long coil casings for the ATLAS experiment's barrel toroid magnet system arrived at CERN on Saturday 2 March by road from Heidelberg. This structure will be part of the largest superconducting toroid magnet ever made.   The first coil casing for the toroidal magnets of Atlas arrives at Building 180. This is the start of an enormous three-dimensional jigsaw puzzle. Each of the eight sets of double pancake coils will be housed inside aluminium coil casings, which in turn will be held inside a stainless steel vacuum vessel. A huge construction, the casing that arrived at CERN measures 25 metres in length and 5 metres in width. It weighs 20 tones. And this is just the beginning of the toroid jigsaw: by early April a batch of four double pancake coils, which altogether weighs 65 tones, will arrive from Ansaldo in Italy. The first vacuum vessel will also be arriving from Felguera in Spain this month. It will take about two years for all these 25 m long structures of casings, coils a...


    王大明; 凌锋; 王安顺


    Objective To explore the causes, prevention, and management of the complications during intracranial aneurysm embolization with controllable coils (mechanical detachable spiral, MDS; and Guglielmi detachable coil, GDC). Methods Retrospective review of 120 cases with 125 intracranial aneurysms embolized with controllable coils from March 1995 to July 1999 was conducted. The 20 accidents (in 18 cases) including aneurysm rupture, over-embolization, protrusion of coil end into the parent artery, and thrombosis of the parent artery were analyzed. Results Among the 20 accidents, there were 6 aneurysm ruptures, 6 over-embolizations (in 5cases), 6 coil protrusions, and 2 thromboses (one was secondary to coil protrusion). The embolizationrelated mortality was 3.33% (4/120), the permanent neurological deficit was 1.67% (2/120), and the transitory neurological deficit was 3.33% (4/120). The occurrence and outcome of the complications were related to the embolizing technique, the pattern of aneurysm and its parent artery, the imperfection of embolic materials, and the observation and management during embolization. Conclusion Skilled embolizing technique, better understanding of the angio-anatomy of an aneurysm and its parent artery, correct judgement and management during embolization, and improvement of embolic materials are beneficial to the reduction of complications and to the melioration of the outcome of complications.

  4. Endovascular therapy of arteriovenous fistulae with electrolytically detachable coils

    Jansen, O.; Doerfler, A.; Forsting, M.; Hartmann, M.; Kummer, R. von; Tronnier, V.; Sartor, K. [Dept. of Neuroradiology, University of Heidelberg Medical School (Germany)


    We report our experience in using Guglielmi electrolytically detachable coils (GDC) alone or in combination with other materials in the treatment of intracranial or cervical high-flow fistulae. We treated 14 patients with arteriovenous fistulae on brain-supplying vessels - three involving the external carotid or the vertebral artery, five the cavernous sinus and six the dural sinuses - by endovascular occlusion using electrolytically detachable platinum coils. The fistula was caused by trauma in six cases. In one case Ehlers-Danlos syndrome was the underlying disease, and in the remaining seven cases no aetiology could be found. Fistulae of the external carotid and vertebral arteries and caroticocavernous fistulae were reached via the transarterial route, while in all dural fistulae a combined transarterial-transvenous approach was chosen. All fistulae were treated using electrolytically detachable coils. While small fistulae could be occluded with electrolytically detachable coils alone, large fistulae were treated by using coils to build a stable basket for other types of coil or balloons. In 11 of the 14 patients, endovascular treatment resulted in complete occlusion of the fistula; in the remaining three occlusion was subtotal. Symptoms and signs were completely abolished by this treatment in 12 patients and reduced in 2. On clinical and neuroradiological follow-up (mean 16 months) no reappearance of symptoms was recorded. (orig.)

  5. [Surgical Removal of Migrated Coil after Embolization of Jejunal Variceal Bleeding: A Case Report].

    Kim, Junhwan; Lee, Danbi; Oh, Kyunghwan; Lee, Mingee; So, Seol; Yang, Dong Hoon; Kim, Chan Wook; Gwon, Dong Il; Chung, Young Hwa


    Jejunal variceal bleeding is less common compared with esophagogastric varices in patients with portal hypertension. However, jejunal variceal bleeding can be fatal without treatment. Treatments include surgery, transjugular intrahepatic porto-systemic shunt (TIPS), endoscopic sclerotherapy, percutaneous coil embolization, and balloon-occluded retrograde transvenous obliteration (BRTO). Percutaneous coil embolization can be considered as an alternative treatment option for those where endoscopic sclerotherapy, surgery, TIPS or BRTO are not possible. Complications of percutaneous coil embolization have been reported, including coil migration. Herein, we report a case of migration of the coil into the jejunal lumen after percutaneous coil embolization for jejunal variceal bleeding. The migrated coil was successfully removed using surgery.

  6. Improved SNR of phased-array PERES coils via simulation study

    RodrIguez, Alfredo O [Centro de Investigacion en Imagenologia e Instrumentacion Medica, Universidad Autonoma Metropolitana Iztapalapa, Av. San Rafael Atlixco 186, Mexico, DF, 09340 (Mexico); Medina, LucIa [DISCA, Instituto de Investigacion en Matematicas Aplicadas y Sistemas, Universidad Nacional Autonoma de Mexico, AP 20-728, Admo. No. 20, 01000 Mexico, DF (Mexico); Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF (Mexico)


    A computational comparison of signal-to-noise ratio (SNR) was performed between a conventional phased array of two circular-shaped coils and a petal resonator surface array. The quasi-static model and phased-array optimum SNR were combined to derive an SNR formula for each array. Analysis of mutual inductance between coil petals was carried out to compute the optimal coil separation and optimum number of petal coils. Mutual interaction between coil arrays was not included in the model because this does not drastically affect coil performance. Phased arrays of PERES coils show a 114% improvement in SNR over that of the simplest circular configuration. (note)

  7. Rationally designed coiled-coil DNA looping peptides control DNA topology.

    Gowetski, Daniel B; Kodis, Erin J; Kahn, Jason D


    Artificial DNA looping peptides were engineered to study the roles of protein and DNA flexibility in controlling the geometry and stability of protein-mediated DNA loops. These LZD (leucine zipper dual-binding) peptides were derived by fusing a second, C-terminal, DNA-binding region onto the GCN4 bZip peptide. Two variants with different coiled-coil lengths were designed to control the relative orientations of DNA bound at each end. Electrophoretic mobility shift assays verified formation of a sandwich complex containing two DNAs and one peptide. Ring closure experiments demonstrated that looping requires a DNA-binding site separation of 310 bp, much longer than the length needed for natural loops. Systematic variation of binding site separation over a series of 10 constructs that cyclize to form 862-bp minicircles yielded positive and negative topoisomers because of two possible writhed geometries. Periodic variation in topoisomer abundance could be modeled using canonical DNA persistence length and torsional modulus values. The results confirm that the LZD peptides are stiffer than natural DNA looping proteins, and they suggest that formation of short DNA loops requires protein flexibility, not unusual DNA bendability. Small, stable, tunable looping peptides may be useful as synthetic transcriptional regulators or components of protein-DNA nanostructures.

  8. Transforming the Energy Landscape of a Coiled-Coil Peptide via Point Mutations.

    Röder, Konstantin; Wales, David J


    We analyze the effect of point mutations on the energy landscape of a coiled-coil peptide, GCN4-pLI, where the native state is a parallel tetrameric configuration formed from two identical dimers. Experimentally, a single mutation, E20S, supports both antiparallel and parallel structures. Here, we analyze the potential energy landscapes of the dimeric units for the parent sequence and four mutants, namely E20S, E20A, E20P, and E20G. Despite sharing characteristic funnels containing the parallel and antiparallel structures, the point mutations change some parts of the landscape quite dramatically, and we predict new intermediate structures and characterize the associated heat capacities. For the mutants we predict that kinked intermediate structures facilitate the transition between parallel and antiparallel morphologies, in contrast to the parent sequence. Furthermore, we predict a change from a multifunnel energy landscape in the E20S mutant to a landscape dominated by an underlying single funnel in the parent sequence, with accompanying heat capacity signatures. Our results imply that changes in the landscape due to mutations might provide useful tools for functional protein design.

  9. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice.

    Walwyn, W M; Keith, D E; Wei, W; Tan, A M; Xie, C W; Evans, C J; Kieffer, B L; Maidment, N T


    Although mu opioid receptors desensitize in various cell lines in vitro, the relationship of this change in signaling efficacy to the development of tolerance in vivo remains uncertain. It is clear that a system is needed in which functional mu opioid receptor expression is obtained in appropriate neurons so that desensitization can be measured, manipulated, and mutated receptors expressed in this environment. We have developed a recombinant system in which expression of a flag-tagged mu opioid receptor is returned to dorsal root ganglia neurons from mu opioid receptor knockout mice in vitro. Flow cytometry analysis showed that adenoviral-mediated expression of the amino-terminal flag-tagged mu opioid receptor in neurons resulted in approximately 1.3x10(6) receptors/cell. Many mu opioid receptor cell lines express a similar density of receptors but this is approximately 7x greater than the number of endogenous receptors expressed by matched wild-type neurons. Inhibition of the high voltage-activated calcium currents in dorsal root ganglia neurons by the mu agonist, D-Ala(2), N-MePhe(4), Gly(5)-ol-enkephalin (DAMGO), was not different between the endogenous and flag-tagged receptor at several concentrations of DAMGO used. Both receptors desensitized equally over the first 6 h of DAMGO pre-incubation, but after 24 h the response of the endogenous receptor to DAMGO had desensitized further than the flag- tagged receptor (71+/-3 vs 29+/-7% respectively; P<0.002), indicating less desensitization in neurons expressing a higher density of receptor. Using flow cytometry to quantify the percentage of receptors remaining on the neuronal cell surface, the flag-tagged receptor internalized by 17+/-1% after 20 min and 55+/-2% after 24 h of DAMGO. These data indicate that this return of function model in neurons recapitulates many of the characteristics of endogenous mu opioid receptor function previously identified in non-neuronal cell lines.

  10. Biochemical and molecular dynamic simulation analysis of a weak coiled coil association between kinesin-II stalks.

    Harinath Doodhi

    Full Text Available DEFINITION: Kinesin-2 refers to the family of motor proteins represented by conserved, heterotrimeric kinesin-II and homodimeric Osm3/Kif17 class of motors. BACKGROUND: Kinesin-II, a microtubule-based anterograde motor, is composed of three different conserved subunits, named KLP64D, KLP68D and DmKAP in Drosophila. Although previous reports indicated that coiled coil interaction between the middle segments of two dissimilar motor subunits established the heterodimer, the molecular basis of the association is still unknown. METHODOLOGY/PRINCIPAL FINDINGS: Here, we present a detailed heterodimeric association model of the KLP64D/68D stalk supported by extensive experimental analysis and molecular dynamic simulations. We find that KLP64D stalk is unstable, but forms a weak coiled coil heteroduplex with the KLP68D stalk when coexpressed in bacteria. Local instabilities, relative affinities between the C-terminal stalk segments, and dynamic long-range interactions along the stalks specify the heterodimerization. Thermal unfolding studies and independent simulations further suggest that interactions between the C-terminal stalk fragments are comparatively stable, whereas the N-terminal stalk reversibly unfolds at ambient temperature. CONCLUSIONS/SIGNIFICANCE: Results obtained in this study suggest that coiled coil interaction between the C-terminal stalks of kinesin-II motor subunits is held together through a few hydrophobic and charged interactions. The N-terminal stalk segments are flexible and could uncoil reversibly during a motor walk. This supports the requirement for a flexible coiled coil association between the motor subunits, and its role in motor function needs to be elucidated.

  11. Nitroxid-vermittelte Polymerisation mittels NMR-Sonden tragender Initiatoren zur Darstellung von coil-rod-coil-Blockcopolymeren

    Tietz, Marco


    A systematic synthesis for coil-rod-coil(c-r-c) block copolymers with differing material characteristics should lead to the usage of c-r-c block copolymers as surface probes and for the study of the self assembling behavior of c-r-c block copolymers. Therefor 2,2,5-Trimethyl-4-phenyl-3-azahexane-3-nitroxide (TIPNO) based alkoxyamines with covalently attached NMR probes where synthesized starting from nitroxides and functionalized styrenes. These alkoxyamines were used as initiators f...

  12. Parameters assessment of the inductively-coupled circuit for wireless power transfer

    Isaev, Yu N.; Vasileva, O. V.; Budko, A. A.; Lefebvre, S.


    In this paper, a wireless power transfer model through the example of inductively-coupled coils of irregular shape in software package COMSOL Multiphysics is studied. Circuit parameters, such as inductance, coil resistance and self-capacitance were defined through electromagnetic energy by the finite-element method. The study was carried out according to Helmholtz equation. Spatial distribution of current per unit depending on frequency and the coupling coefficient for analysis of resonant frequency and spatial distribution of the vector magnetic potential at different distances between coils were presented. The resulting algorithm allows simulating the wireless power transfer between the inductively coupled coils of irregular shape with the assessment of the optimal parameters.

  13. Optimized ground coupled heat pump mechanical package

    Catan, M.A.


    This project addresses the question of how well a ground coupled heat pump system could perform with a heat pump which was designed specifically for such systems operating in a northern climate. Conventionally, systems are designed around water source heat pumps which are not designed for ground coupled heat pump application. The objective of the project is to minimize the life cycle cost for a ground coupled system given the freedom to design the heat pump and the ground coil in concert. In order to achieve this objective a number of modeling tools were developed which will likely be of interest in their own right.

  14. Testing of a Single 11 T $Nb_3Sn$ Dipole Coil Using a Dipole Mirror Structure

    Zlobin, Alexander [Fermilab; Andreev, Nicolai [Fermilab; Barzi, Emanuela [Fermilab; Chlachidze, Guram [Fermilab; Kashikhin, Vadim [Fermilab; Nobrega, Alfred [Fermilab; Novitski, Igor [Fermilab; Turrioni, Daniele [Fermilab; Karppinen, Mikko [CERN; Smekens, David [CERN


    FNAL and CERN are developing an 11 T Nb3Sn dipole suitable for installation in the LHC. To optimize coil design parameters and fabrication process and study coil performance, a series of 1 m long dipole coils is being fabricated. One of the short coils has been tested using a dipole mirror structure. This paper describes the dipole mirror magnetic and mechanical designs, and reports coil parameters and test results.

  15. [High resolution MR imaging of the hip using pelvic phased-array coil].

    Niitsu, M; Mishima, H; Itai, Y


    A pelvic phased-array coil was applied to obtain high resolution MR images of the hip. Three-mm-thick fast spinecho images were obtained in seven hips. Images with a pelvic coil enhanced delineation of acetabular labrum and articular cartilage more clearly than those with a body coil or flexible-surface coil. The use of a pelvic coil in imaging of the hip may be of diagnostic value because of its superior delineation.

  16. Liquid Crystalline Assembly of Coil-Rod-Coil Molecules with Lateral Methyl Groups into 3-D Hexagonal and Tetragonal Assemblies

    Wang, Zhuoshi; Lan, Yu; Zhong, Keli; Liang, Yongri; Chen, Tie; Jin, Long Yi


    In this paper, we report the synthesis and self-assembly behavior of coil-rod-coil molecules, consisting of three biphenyls linked through a vinylene unit as a conjugated rod segment and poly(ethylene oxide) (PEO) with a degree of polymerization (DP) of 7, 12 and 17, incorporating lateral methyl groups between the rod and coil segments as the coil segment. Self-organized investigation of these molecules by means of differential scanning calorimetry (DSC), thermal polarized optical microscopy (POM) and X-ray diffraction (XRD) reveals that the lateral methyl groups attached to the surface of rod and coil segments, dramatically influence the self-assembling behavior in the liquid-crystalline mesophase. Molecule 1 with a relatively short PEO coil length (DP = 7) self-assembles into rectangular and oblique 2-dimensional columnar assemblies, whereas molecules 2 and 3 with DP of 12 and 17 respectively, spontaneously self-organize into unusual 3-dimensional hexagonal close-packed or body-centered tetragonal assemblies. PMID:24699045

  17. Rice Cellulose SynthaseA8 Plant-Conserved Region Is a Coiled-Coil at the Catalytic Core Entrance

    Rushton, Phillip S.; Olek, Anna T.; Makowski, Lee; Badger, John; Steussy, C. Nicklaus; Carpita, Nicholas C.; Stauffacher, Cynthia V.


    The crystallographic structure of a rice (Oryza sativa) cellulose synthase, OsCesA8, plant-conserved region (P-CR), one of two unique domains in the catalytic domain of plant CesAs, was solved to 2.4 Å resolution. Two antiparallel α-helices form a coiled-coil domain linked by a large extended connector loop containing a conserved trio of aromatic residues. The P-CR structure was fit into a molecular envelope for the P-CR domain derived from small-angle X-ray scattering data. The P-CR structure and molecular envelope, combined with a homology-based chain trace of the CesA8 catalytic core, were modeled into a previously determined CesA8 small-angle X-ray scattering molecular envelope to produce a detailed topological model of the CesA8 catalytic domain. The predicted position for the P-CR domain from the molecular docking models places the P-CR connector loop into a hydrophobic pocket of the catalytic core, with the coiled-coil aligned near the entrance of the substrate UDP-glucose into the active site. In this configuration, the P-CR coiled-coil alone is unlikely to regulate substrate access to the active site, but it could interact with other domains of CesA, accessory proteins, or other CesA catalytic domains to control substrate delivery.

  18. Liquid Crystalline Assembly of Coil-Rod-Coil Molecules with Lateral Methyl Groups into 3-D Hexagonal and Tetragonal Assemblies

    Zhuoshi Wang


    Full Text Available In this paper, we report the synthesis and self-assembly behavior of coil-rod-coil molecules, consisting of three biphenyls linked through a vinylene unit as a conjugated rod segment and poly(ethylene oxide (PEO with a degree of polymerization (DP of 7, 12 and 17, incorporating lateral methyl groups between the rod and coil segments as the coil segment. Self-organized investigation of these molecules by means of differential scanning calorimetry (DSC, thermal polarized optical microscopy (POM and X-ray diffraction (XRD reveals that the lateral methyl groups attached to the surface of rod and coil segments, dramatically influence the self-assembling behavior in the liquid-crystalline mesophase. Molecule 1 with a relatively short PEO coil length (DP = 7 self-assembles into rectangular and oblique 2-dimensional columnar assemblies, whereas molecules 2 and 3 with DP of 12 and 17 respectively, spontaneously self-organize into unusual 3-dimensional hexagonal close-packed or body-centered tetragonal assemblies.

  19. Design of the dummy coil for magnet power supply

    Kim, Chang-Hwan, E-mail:; Choi, Jae-Hoon; Jin, Jong-Kook; Lee, Dong-Keun; Kong, Jong-Dea; Joung, Nam-Young; Kim, Sang-Tae; Kim, Young-Jin; Kim, Yang-Soo; Kwon, Myeun


    Highlights: • It is necessary to confirm safety of the MPS on a dummy coil before the operating it. • We selected and designed the water cooling type dummy coil to test on the MPS's rating (12.5 kA) test. • For the design of the dummy coil, we considered requirements about electrical, structural and water cooling. • We will test as the rating power after MPS upgrade and that test will do before every KSTAR campaign. -- Abstract: It is necessary to test it on a dummy coil, before using a magnet power supply (MPS) to energize a Poloidal Field (PF) coil in the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The dummy coil should accept the same large current from the MPS as the PF coil and be within the capability of the utilities located at the KSTAR site. Therefore a coil design based on the characteristics of the MPS and other restrictive conditions needed to be made. There are three requirements to be met in the design: an electrical requirement, a structural requirement, and a water cooling requirement. The electrical requirement was that the coil should have an inductance of 40 mH. For the structural requirement, the material should be non magnetic. The coil support structure and water cooling manifold were made of SUS 304. The water cooling requirement was that there should be sufficient flow rate so that the temperature rise ΔT should not exceed 12 °C for operation at 12.5 kA for 5 min. Square cross-section hollow conductor with dimensions of 38.1 mm × 38.1 mm was used with a 25.4 mm center hole for cooling water. However, as a result of tests, it was found that the electrical and structural requirements were satisfied but that the water cooling was over designed. It is imperative that the verification will be redone for a test with 12.5 kA for 5 min.

  20. Coupled transfers; Transferts couples

    Nicolas, X.; Lauriat, G.; Jimenez-Rondan, J. [Universite de Marne-la-Vallee, Lab. d' Etudes des Transferts d' Energie et de Matiere (LETEM), 77 (France); Bouali, H.; Mezrhab, A. [Faculte des Sciences, Dept. de Physique, Lab. de Mecanique et Energetique, Oujda (Morocco); Abid, C. [Ecole Polytechnique Universitaire de Marseille, IUSTI UMR 6595, 13 Marseille (France); Stoian, M.; Rebay, M.; Lachi, M.; Padet, J. [Faculte des Sciences, Lab. de Thermomecanique, UTAP, 51 - Reims (France); Mladin, E.C. [Universitaire Polytechnique Bucarest, Faculte de Genie Mecanique, Bucarest (Romania); Mezrhab, A. [Faculte des Sciences, Lab. de Mecanique et Energetique, Dept. de Physique, Oujda (Morocco); Abid, C.; Papini, F. [Ecole Polytechnique, IUSTI, 13 - Marseille (France); Lorrette, C.; Goyheneche, J.M.; Boechat, C.; Pailler, R. [Laboratoire des Composites ThermoStructuraux, UMR 5801, 33 - Pessac (France); Ben Salah, M.; Askri, F.; Jemni, A.; Ben Nasrallah, S. [Ecole Nationale d' Ingenieurs de Monastir, Lab. d' Etudes des Systemes Thermiques et Energetiques (Tunisia); Grine, A.; Desmons, J.Y.; Harmand, S. [Laboratoire de Mecanique et d' Energetique, 59 - Valenciennes (France); Radenac, E.; Gressier, J.; Millan, P. [ONERA, 31 - Toulouse (France); Giovannini, A. [Institut de Mecanique des Fluides de Toulouse, 31 (France)


    This session about coupled transfers gathers 30 articles dealing with: numerical study of coupled heat transfers inside an alveolar wall; natural convection/radiant heat transfer coupling inside a plugged and ventilated chimney; finite-volume modeling of the convection-conduction coupling in non-stationary regime; numerical study of the natural convection/radiant heat transfer coupling inside a partitioned cavity; modeling of the thermal conductivity of textile reinforced composites: finite element homogenization on a full periodical pattern; application of the control volume method based on non-structured finite elements to the problems of axisymmetrical radiant heat transfers in any geometries; modeling of convective transfers in transient regime on a flat plate; a conservative method for the non-stationary coupling of aero-thermal engineering codes; measurement of coupled heat transfers (forced convection/radiant transfer) inside an horizontal duct; numerical simulation of the combustion of a water-oil emulsion droplet; numerical simulation study of heat and mass transfers inside a reactor for nano-powders synthesis; reduction of a combustion and heat transfer model of a direct injection diesel engine; modeling of heat transfers inside a knocking operated spark ignition engine; heat loss inside an internal combustion engine, thermodynamical and flamelet model, composition effects of CH{sub 4}H{sub 2} mixtures; experimental study and modeling of the evolution of a flame on a solid fuel; heat transfer for laminar subsonic jet of oxygen plasma impacting an obstacle; hydrogen transport through a A-Si:H layer submitted to an hydrogen plasma: temperature effects; thermal modeling of the CO{sub 2} laser welding of a magnesium alloy; radiant heat transfer inside a 3-D environment: application of the finite volume method in association with the CK model; optimization of the infrared baking of two types of powder paints; optimization of the emission power of an infrared

  1. Structural mapping of the coiled-coil domain of a bacterial condensin and comparative analyses across all domains of life suggest conserved features of SMC proteins.

    Waldman, Vincent M; Stanage, Tyler H; Mims, Alexandra; Norden, Ian S; Oakley, Martha G


    The structural maintenance of chromosomes (SMC) proteins form the cores of multisubunit complexes that are required for the segregation and global organization of chromosomes in all domains of life. These proteins share a common domain structure in which N- and C- terminal regions pack against one another to form a globular ATPase domain. This "head" domain is connected to a central, globular, "hinge" or dimerization domain by a long, antiparallel coiled coil. To date, most efforts for structural characterization of SMC proteins have focused on the globular domains. Recently, however, we developed a method to map interstrand interactions in the 50-nm coiled-coil domain of MukB, the divergent SMC protein found in γ-proteobacteria. Here, we apply that technique to map the structure of the Bacillus subtilis SMC (BsSMC) coiled-coil domain. We find that, in contrast to the relatively complicated coiled-coil domain of MukB, the BsSMC domain is nearly continuous, with only two detectable coiled-coil interruptions. Near the middle of the domain is a break in coiled-coil structure in which there are three more residues on the C-terminal strand than on the N-terminal strand. Close to the head domain, there is a second break with a significantly longer insertion on the same strand. These results provide an experience base that allows an informed interpretation of the output of coiled-coil prediction algorithms for this family of proteins. A comparison of such predictions suggests that these coiled-coil deviations are highly conserved across SMC types in a wide variety of organisms, including humans. © 2015 Wiley Periodicals, Inc.

  2. Magnetic field modeling with a set of individual localized coils.

    Juchem, Christoph; Nixon, Terence W; McIntyre, Scott; Rothman, Douglas L; de Graaf, Robin A


    A set of generic, circular individual coils is shown to be capable of generating highly complex magnetic field distributions in a flexible fashion. Arbitrarily oriented linear field gradients can be generated in three-dimensional as well as sliced volumes at amplitudes that allow imaging applications. The multi-coil approach permits the simultaneous generation of linear MRI encoding fields and complex shim fields by the same setup, thereby reducing system complexity. The choice of the sensitive volume over which the magnetic fields are optimized remains temporally and spatially variable at all times. The restriction of the field synthesis to experimentally relevant, smaller volumes such as single slices directly translates into improved efficiency, i.e. higher magnetic field amplitudes and/or reduced coil currents. For applications like arterial spin labeling, signal spoiling and diffusion weighting, perfect linearity of the gradient fields is not required and reduced demands on accuracy can also be readily translated into improved efficiency. The first experimental realization was achieved for mouse head MRI with 24 coils that were mounted on the surface of a cylindrical former. Oblique linear field gradients of 20 kHz/cm (47 mT/m) were generated with a maximum current of 1.4A which allowed radial imaging of a mouse head. The potential of the new approach for generating arbitrary magnetic field shapes is demonstrated by synthesizing the more complex, higher order spherical harmonic magnetic field distributions X2-Y2, Z2 and Z2X. The new multi-coil approach provides the framework for the integration of conventional imaging and shim coils into a single multi-coil system in which shape, strength, accuracy and spatial coverage of the magnetic field can be specifically optimized for the application at hand.

  3. Local Multi-Channel RF Surface Coil versus Body RF Coil Transmission for Cardiac Magnetic Resonance at 3 Tesla: Which Configuration Is Winning the Game?

    Weinberger, Oliver; Winter, Lukas; Dieringer, Matthias A; Els, Antje; Oezerdem, Celal; Rieger, Jan; Kuehne, Andre; Cassara, Antonino M; Pfeiffer, Harald; Wetterling, Friedrich; Niendorf, Thoralf


    The purpose of this study was to demonstrate the feasibility and efficiency of cardiac MR at 3 Tesla using local four-channel RF coil transmission and benchmark it against large volume body RF coil excitation. Electromagnetic field simulations are conducted to detail RF power deposition, transmission field uniformity and efficiency for local and body RF coil transmission. For both excitation regimes transmission field maps are acquired in a human torso phantom. For each transmission regime flip angle distributions and blood-myocardium contrast are examined in a volunteer study of 12 subjects. The feasibility of the local transceiver RF coil array for cardiac chamber quantification at 3 Tesla is demonstrated. Our simulations and experiments demonstrate that cardiac MR at 3 Tesla using four-channel surface RF coil transmission is competitive versus current clinical CMR practice of large volume body RF coil transmission. The efficiency advantage of the 4TX/4RX setup facilitates shorter repetition times governed by local SAR limits versus body RF coil transmission at whole-body SAR limit. No statistically significant difference was found for cardiac chamber quantification derived with body RF coil versus four-channel surface RF coil transmission. Our simulation also show that the body RF coil exceeds local SAR limits by a factor of ~2 when driven at maximum applicable input power to reach the whole-body SAR limit. Pursuing local surface RF coil arrays for transmission in cardiac MR is a conceptually appealing alternative to body RF coil transmission, especially for patients with implants.

  4. Closed inductively coupled plasma cell

    Manning, Thomas J.; Palmer, Byron A.; Hof, Douglas E.


    A closed inductively coupled plasma cell generates a relatively high power, low noise plasma for use in spectroscopic studies. A variety of gases can be selected to form the plasma to minimize spectroscopic interference and to provide a electron density and temperature range for the sample to be analyzed. Grounded conductors are placed at the tube ends and axially displaced from the inductive coil, whereby the resulting electromagnetic field acts to elongate the plasma in the tube. Sample materials can be injected in the plasma to be excited for spectroscopy.

  5. Optical microfiber coil resonator refractometric sensor.

    Xu, Fei; Horak, Peter; Brambilla, Gilberto


    We present a novel refractometric sensor based on a coated all-coupling optical-fiber-nanowire microcoil resonator which is robust, compact, and comprises an intrinsic fluidic channel. We calculate the device sensitivity and find its dependence on the nanowire diameter and coating thickness. A sensitivity as high as 700 nm/RIU and a refractive index resolution as low as 10(-10) are predicted.

  6. Temperature Profile Measurements During Heat Treatment of BSCCO 2212 Coils

    Tollestrup, Alvin; /Fermilab


    The temperature profile of two different BSCCO 2212 coils has been analyzed. The profiles are obtained from thermocouples imbedded in the windings during the heat treatment that activates the 2212. The melting and freezing of the 2212 is clearly observed. A model that describes the data and can be used to guide the processing of new coils has been developed. We have obtained the thermal history of two BSCCO coils, one from NHMFL (1) that had 10 layers of 1 mm diameter wire with 0.15 mm insulation and a second coil from OST that had 24 layers with similar insulation and conductor size. Both coils had thermocouples imbedded in the windings and excellent recordings of the temperature over the whole reaction cycle were available for analysis. There are several features that we will address in this note. Measurements have shown that the I{sub c} of the conductor is a sensitive function of its thermal history. This brings up the question of the absolute accuracy of the thermometry in the range around 882 C, the MP of 2212. The reference for the treatment profile is really related to this MP and to small deviations around it. Since the heat of fusion of 2212 is rather large, it generates a clear signal during the melting and cooling transition that automatically generates the relative temperature markers. The physics is the same as the way ice in water maintains an isothermal environment until it is all melted. A related question is the thermal response time of the coil package. The temperature cycles that are being used to optimize strand and small coils can have rapid changes easily implemented whereas a large coil may have such a large thermal time constant that the optimum cycle may not be attainable. A simple analytical model that works well for small solenoids has been developed and an ANSYS (5) program that works for larger coils with more complicated geometry has been set up but will not be discussed in this note.

  7. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3

    Ghiselli Giancarlo


    Full Text Available Abstract Background The structural maintenance of chromosome proteins SMC1 and SMC3 play an important role in the maintenance of chromosomal integrity by preventing the premature separation of the sister chromatids at the onset of anaphase. The two proteins are constitutive components of the multimeric complex cohesin and form dimers by interacting at their central globular regions. Results In order to identify proteins that by binding to SMC3 may interfere with the protein dimerization process, a human cDNA library was screened by the yeast two-hybrid system by using the hinge region of SMC3 as bait. This has lead to the identification of Hinderin, a novel five domains protein including two coiled-coil motifs and sharing a strikingly structural similarity to the SMC family of proteins. Hinderin is ubiquitously expressed in human tissues. Orthologue forms of the protein are present in other vertebrates but not in lower organisms. A mapping of the interaction sites revealed that the N- and C-terminal globular domains mediate the binding of Hinderin to SMC3. Hinderin/SMC3 complexes could be recovered by immunoprecipitation from cell lysates using an anti-SMC3 antibody, thus demonstrating that the two proteins interact in vivo. On the contrary, Hinderin did not interact with SMC1. In vivo the rate of SMC1/SMC3 interaction was decreased by the ectopic expression of Hinderin. Conclusions Hinderin is a novel binding partner of SMC3. Based on its ability to modulate SMC1/SMC3 interaction we postulate that Hinderin affects the availability of SMC3 to engage in the formation of multimeric protein complexes.

  8. Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction.

    Pelassa, Ilaria; Corà, Davide; Cesano, Federico; Monje, Francisco J; Montarolo, Pier Giorgio; Fiumara, Ferdinando


    The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but the general extent of their association in proteomes is unknown. Furthermore, the structural mechanisms by which their expansion causes disease are not well understood, and these repeats are generally thought to misfold upon expansion into aggregation-prone β-sheet structures like amyloids. However, recent evidence indicates a critical role for coiled-coil (CC) structures in triggering aggregation and toxicity of polyQ-expanded proteins, raising the possibility that polyA repeats may as well form these structures, by themselves or in association with polyQ. We found through bioinformatics screenings that polyA, polyQ and polyQA repeats have a phylogenetically graded association in human and non-human proteomes and associate/overlap with CC domains. Circular dichroism and cross-linking experiments revealed that polyA repeats can form--alone or with polyQ and polyQA--CC structures that increase in stability with polyA length, forming higher-order multimers and polymers in vitro. Using structure-guided mutagenesis, we studied the relevance of polyA CCs to the in vivo aggregation and toxicity of RUNX2--a polyQ/polyA protein associated with cleidocranial dysplasia upon polyA expansion--and found that the stability of its polyQ/polyA CC controls its aggregation, localization and toxicity. These findings indicate that, like polyQ, polyA repeats form CC structures that can trigger protein aggregation and toxicity upon expansion in human genetic diseases. © The Author 2014. Published by Oxford University Press.

  9. Performance of Upgraded Cooling System for Lhd Helical Coils

    Hamaguchi, S.; Imagawa, S.; Obana, T.; Yanagi, N.; Moriuchi, S.; Sekiguchi, H.; Oba, K.; Mito, T.; Motojima, O.; Okamura, T.; Semba, T.; Yoshinaga, S.; Wakisaka, H.


    Helical coils of the Large Helical Device (LHD) are large scale superconducting magnets for heliotron plasma experiments. The helical coils had been cooled by saturated helium at 4.4 K, 120 kPa until 2005. An upgrade of the cooling system was carried out in 2006 in order to improve the cryogenic stability of the helical coils and then it has been possible to supply the coils with subcooled helium at 3.2 K, 120 kPa. A designed mass flow of the supplied subcooled helium is 50 g/s. The subcooled helium is generated at a heat exchanger in a saturated helium bath. A series of two centrifugal cold compressors with gas foil bearing is utilized to lower the helium pressure in the bath. The supplied helium temperature is regulated by rotational speed of the cold compressors and power of a heater in the bath. The mass flow of the supplied helium is also controlled manually by a supply valve and its surplus is evaporated by ten heaters at the outlet above the coils. In the present study, the performance of the cooling system has been investigated and a stable operating method has also developed. As the result, it was confirmed that the performance of the upgraded cooling system satisfies the requirements.

  10. Novel TMS coils designed using an inverse boundary element method

    Cobos Sánchez, Clemente; María Guerrero Rodriguez, Jose; Quirós Olozábal, Ángel; Blanco-Navarro, David


    In this work, a new method to design TMS coils is presented. It is based on the inclusion of the concept of stream function of a quasi-static electric current into a boundary element method. The proposed TMS coil design approach is a powerful technique to produce stimulators of arbitrary shape, and remarkably versatile as it permits the prototyping of many different performance requirements and constraints. To illustrate the power of this approach, it has been used for the design of TMS coils wound on rectangular flat, spherical and hemispherical surfaces, subjected to different constraints, such as minimum stored magnetic energy or power dissipation. The performances of such coils have been additionally described; and the torque experienced by each stimulator in the presence of a main magnetic static field have theoretically found in order to study the prospect of using them to perform TMS and fMRI concurrently. The obtained results show that described method is an efficient tool for the design of TMS stimulators, which can be applied to a wide range of coil geometries and performance requirements.

  11. Background field coils for the High Field Test Facility

    Zbasnik, J.P.; Cornish, D.N.; Scanlan, R.M.; Jewell, A.M.; Leber, R.L.; Rosdahl, A.R.; Chaplin, M.R.


    The High Field Test Facility (HFTF), presently under construction at LLNL, is a set of superconducting coils that will be used to test 1-m-o.d. coils of prototype conductors for fusion magnets in fields up to 12 T. The facility consists of two concentric sets of coils; the outer set is a stack of Nb-Ti solenoids, and the inner set is a pair of solenoids made of cryogenically-stabilized, multifilamentary Nb/sub 3/Sn superconductor, developed for use in mirror-fusion magnets. The HFTF system is designed to be parted along the midplane to allow high-field conductors, under development for Tokamak fusion machines, to be inserted and tested. The background field coils were wound pancake-fashion, with cold-welded joints at both the inner and outer diameters. Turn-to-turn insulation was fabricated at LLNL from epoxy-fiberglass strip. The coils were assembled and tested in our 2-m-diam cryostat to verify their operation.

  12. Cryocooled Facilities for Superconducting Coils Testing in Gaseous Helium

    Naumov, A. V.; Keilin, V. E.; Kovalev, I. A.; Surin, M. I.; Shcherbakov, V. I.; Shevchenko, S. A.; Ilin, A. A.

    Two superconducting coil test facilities equipped by Sumitomo SRDK-415D cryocoolers were developed, manufactured and tested. The motivation for their constructing was to make cheaper the testing (and especially training of LTS magnets) by liquid helium (LHe) saving. It is well known that the helium price increases rapidly and this tendency most probably will continue for a long time, as the demand of helium grows faster than its production. The utilization of heat-exchange gas considerably reduces many problems, that arise in the design of completely dry LTS magnets. The goal was to decrease or even completely avoid the consumption of rather expensive liquid helium for testing the laboratory size Nb-Ti and Nb3Sn coils including their training process. Several superconducting magnets were tested by using these facilities. For example, the first facility was successfully used for testing of 13 T, 60 kg coil cooled by cryocooler in helium gas (several torr pressure) heat exchange atmosphere. The precooling time was about 45 hours. The quench current (240 A at 4.2 K) was equal to that reached in the pool boiling LHe cryostat. The second facility with 420 mm wide access bore can be used for testing of corresponding size superconducting coils with very modest consumption of liquid helium with its level well below the lower flange of the coil. Each test facility is equipped by 2 pairs of HTS current leads. Design and operational experience of one of them is described.

  13. Power Supply Changes for NSTX Resistive Wall Mode Coils

    Ramakrishnan, S S.


    The National Spherical Torus Experiment (NSTX) has been designed and installed in the existing facilities at Princeton Plasma Physics Laboratory (PPPL). Most of the hardware, plant facilities, auxiliary sub-systems, and power systems originally used for the Tokamak Fusion Test Reactor (TFTR) have been used with suitable modifications to reflect NSTX needs. Prior to 2004, the NSTX power system was feeding twelve (12) circuits in the machine. In 2004 the Resistive Wall Mode (RWM) Coils were installed on the machine to correct error fields. There are six of these coils installed around the machine in the mid-plane. Since these coils need fast and accurate controls, a Switching Power Amplifier (SPA) with three sub-units was procured, installed and commissioned along with other power loop components. Two RWM Coils were connected in series and fed from one SPA sub-unit. After the initial RWM campaign, operational requirements evolved such that each of the RWM coils now requires separate power and control. Hence a second SPA with three sub-units has been procured and installed. The second unit is of improved design and has the controls and power components completely isolated. The existing thyristor rectifier is used as DC Link to both of the Switching Power Amplifiers. The controls for the RWM are integrated into the overall computer control of the DC Power systems for NSTX. This paper describes the design changes in the RWM Power system for NSTX.

  14. Superconducting flux pump for high-temperature superconductor insert coils of NMR magnets

    Jeong, S.; Lee, H.; Iwasa, Y.


    This paper describes a prototype flux pump recently operated at the MIT Francis Bitter Magnet Laboratory. The results of the prototype flux pump will be used in the development of a full-scale flux pump that will be coupled to a high-temperature superconductor (HTS) insert coil of a high-field NMR magnet. Such an HTS insert is unlikely to operate in persistent mode because of the conductor's low index (n). The flux pump can compensate for field decay in the HTS insert coil and make the insert operate effectively in persistent mode. The flux pump, comprised essentially of a transformer and two switches, all made of superconductor, transfers into the insert coil a fraction of a magnetic energy that is first introduced in the secondary circuit of the transformer by a current supplied to the primary circuit. A prototype flux pump has been designed, fabricated, and operated to demonstrate that a flux pump can indeed supply a small metered current into a load superconducting magnet. A current increment in the range of microamperes has been measured in the magnet after each pumping action. The superconducting prototype flux pump is made of Nb3Sn tape. The pump is placed in a gaseous environment above the liquid helium level to keep its heat dissipation from directly discharged in the liquid; the effluent helium vapor maintains the thermal stability of the flux pump. [This paper is also published in Advances in Cryogenic Engineering Volume 47A, AIP Conference Proceedings Volume 613, pp. 441-448.

  15. Magnetic resonance butterfly coils: Design and application for hyperpolarized 13C studies

    Giovannetti, Giulio; Frijia, Francesca; Attanasio, Simona


    of dedicated coils capable of providing large field of view with high Signal-to-Noise Ratio (SNR) data is of fundamental importance. This work presents magnetostatic simulations and tests of two butterfly coils with different geometries, both designed for 13C hyperpolarized studies of pig heart with a clinical...... 3T scanner. In particular, the paper provides details of the design, modeling, construction and application of the butterfly style coils. While both coils could be successfully employed in single configuration (linear mode), the second prototype was used to design a quadrature surface coil...... constituted by the butterfly and a circular loop both in receive (RX) mode while using a birdcage coil as transmitter (TX). The performance of this coils configuration was compared with the single TX/RX birdcage coil, in order to verify the advantage of the proposed configuration over the volume coil...

  16. Flow diverter assisted coil embolization of a very small ruptured ophthalmic artery aneurysm.

    Dornbos, David; Pillai, Promod; Sauvageau, Eric


    Small ruptured aneurysms present a unique problem to endovascular therapy. We report a case in which a patient presented with subarachnoid hemorrhage and a very small ruptured ophthalmic artery aneurysm, for which endovascular therapy was preferred secondary to severe cardiac comorbidities. Due to the aneurysm size, a small 1.5 mm coil was needed, but presented a significant risk of migration. Conventional stent assisted coiling was considered suboptimal as the small coil could have easily migrated through the strut. We present a novel technique of flow diverter assisted coil embolization in which a coil was placed within the aneurysm and a pipeline embolization device was then partially deployed, jailing the microcatheter and coil mass. Once in place, the coil was detached, securing the aneurysm, and preventing coil migration. Through the use of a flow diverter, some degree of aneurysm protection would still be expected in the event of coil migration toward the ophthalmic artery origin.

  17. Design of a quadrature surface coil for hyperpolarized 13C MRS cardiac metabolism studies in pigs

    Giovannetti, G.; Frijia, F.; Hartwig, V.;


    This work describes the design of a quadrature surface coil constituted by a circular loop and a butterfly coil, employed in transmit/receive (TX/RX) mode for hyperpolarized 13C studies of pig heart with a clinical 3T scanner. The coil characterization is performed by developing an SNR model...... for coil performance evaluation in terms of coil resistance, sample-induced resistance and magnetic field pattern. Experimental SNR-vs.-depth profiles, extracted from the [1-13C]acetate phantom chemical shift image (CSI), showed good agreement with the theoretical SNR-vs.-depth profiles. Moreover......, the performance of the quadrature coil was compared with the single TX/RX circular and TX/RX butterfly coil, in order to verify the advantage of the proposed configuration over the single coils throughout the volume of interest for cardiac imaging in pig. Finally, the quadrature surface coil was tested...

  18. Theoretical signal-to-noise ratio of a slotted surface coil for magnetic resonance imaging

    Ocegueda, K; Solis, S E; Rodriguez, A O


    The analytical expression for the signal-to-noise ratio of a slotted surface coil with an arbitrary number of slots was derived using the quasi-static approach. This surface coil based on the vane-type magnetron tube. To study the coil perfomance, the theoretical signal-to-noise ratio predictions of this coil design were computed using a different number of slots. Results were also compared with theoretical results obtained for a circular coil with similar dimensions. It can be appreciated that slotted surface coil performance improves as the number of coils increases and, outperformed the circular-shaped coil. This makes it a good candidate for other MRI applications involving coil array techniques.

  19. Rebleeding of a Splenic Artery Aneurysm after Coil Embolisation

    Kyra D. Kingma


    Full Text Available Background. Splenic artery aneurysm (SAA is an uncommon and difficult diagnosis. SAA is more common in females. Only 20% of SAA is symptomatic and may present as a rupture. A ruptured SAA is associated with a 25% mortality rate. Case Presentation. We present a case of a male patient with a bleeding SAA that rapidly increased in size. Distal coiling was technically impossible and despite proximal coil embolisation the SAA continued to bleed. A laparotomy including splenectomy and partial pancreatectomy was performed with an uneventful patient recovery. Discussion. Endovascular management is currently considered the optimal treatment of SAA. However, careful monitoring and follow-up is needed after embolisation as rapid recanalization of the SAA may possibly occur, especially when distal coiling of the aneurysm is unsuccessful. Conclusion. Endovascular treatment of an SAA is not necessarily effective. Surgeons must be prepared to perform open procedures to further reduce mortality rates.

  20. Impact response by a foamlike forest of coiled carbon nanotubes

    Daraio, Chiara; Nesterenko, Vitali F.; Jin, Sungho; Wang, Wei; Rao, Apparao M.


    We studied the dynamic response of a foamlike forest of coiled carbon nanotubes under high strain rate deformation using a simple drop-ball test. The method is based on measuring the dynamic force between the ball and the foam on the substrate during the stages of penetration and restitution. The analysis of the forest's morphology after impact has shown no trace of plastic deformation and a full recovery of the foamlike layer of coiled carbon nanotubes under various impact velocities. The contact force exhibits a strongly nonlinear dependence on displacement and appears fundamentally different from the response of a forest of straight carbon nanotubes, and from the Hertzian type of plane-sphere interaction. "Brittle" fracture of the foamlike layer is observed after repeated high velocity impacts. Such layers of coiled nanotubes may be used as a strongly nonlinear spring in discrete systems for monitoring their dynamic behavior and as a nanostructure for localized microimpact protection.