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Sample records for mi casa es

  1. Mi casa es esta pieza”: migración femenina y precariedad habitacional en la Ciudad de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Juliana Marcús

    2017-12-01

    Full Text Available El objetivo de este artículo es analizar, por un lado, el escenario migratorio de nueve mujeres y sus familias tomando en consideración las motivaciones de la migración y el proceso de desplazamiento desde sus lugares de origen hacia la Ciudad de Buenos Aires y, por otro lado, el proceso de integración en la sociedad receptora desde su residencia en hoteles-pensión de la ciudad capital. Esta modalidad del hábitat popular urbano, junto con los conventillos, inquilinatos, villas miseria, asentamientos y casas tomadas pone de relieve la precariedad habitacional de la ciudad. Se realizaron entrevistas en profundidad y observaciones participantes en los hoteles-pensión.Uno de los resultados obtenidos es que la ausencia de propuestas integradoras de política habitacional dirigidas a los sectores populares, sobre todo migrantes internos y de países limítrofes, incide en la falta de acceso a la vivienda digna. En este sentido, el Estado se desentiende en cuanto a políticas habitacionales destinadas a la integración. Las mujeres migrantes entrevistadas han sido seducidas y atraídas por los beneficios que otorga la gran ciudad y simultáneamente abandonadas por el Estado, pues los mecanismos de recepción y albergue son sumamente escasos. No sólo se les niega el derecho a la ciudad sino también se las despoja del derecho a una vivienda digna y se las “condena” a vivir en viviendas precarias o en los márgenes de la ciudad.

  2. 78 FR 19066 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MI CASA; Invitation for...

    Science.gov (United States)

    2013-03-28

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2013 0035] Requested Administrative Waiver of the Coastwise Trade Laws: Vessel MI CASA; Invitation for Public Comments AGENCY... CASA is: Intended Commercial Use of Vessel: Passenger charters. Geographic Region: Massachusetts, New...

  3. SENTIDOS DE DESACOLHIMENTO DE MÃES SOCIAIS DOS SISTEMAS DE CASAS LARES

    OpenAIRE

    Teixeira, Paulo André Sousa; Villachan-Lyra, Pompéia

    2015-01-01

    A institucionalização de crianças brasileiras é um fenômeno histórico. A presente pesquisa teve por objetivo problematizar os sentidos produzidos pelas mães sociais de uma casa de acolhimento no que diz respeito ao desligamento das crianças em situação de acolhimento prolongado, sendo realizada em uma ONG que trabalha com o sistema "Casa Lar". A coleta de dados foi efetuada a partir de um grupo focal, com o uso de um roteiro de entrevista semiestruturado. Os dados foram interpretados com base...

  4. SOBRE LA TRADUCCIÓN DEL POEMA DE GABRIEL ARESTI "LA CASA DE MI PADRE"

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    Vladimer Luarsabishvili

    2014-10-01

    Full Text Available En este artículo se analizan varias versiones del poema de Gabriel Aresti «La casa de mi padre». El autor profundiza en la teoría y práctica de la traducción con el ejemplo de varios traductores. En el artículo se citan ejemplos concretos de diversas traducciones de  K. Gamsakhurdia, M. Tsvetaeva, V. Nabokov, J. Borges etc. Al término de su trabajo el autor propone su propia versión de traducción al ruso del poema de Gabriel Aresti «La casa de mi padre».

  5. Mi Casa Es Su Casa: Sandra Tauler--City Librarian, Calexico, CA

    Science.gov (United States)

    Library Journal, 2005

    2005-01-01

    Sandra Tauler has tailored her collection and services to the needs of a community that is 97 percent Hispanic. Unfortunately, that's only half the job. The other half is getting potential users through the door. The solution Tauler and other Imperial Valley librarians came up with was Proyecto Televista. With LSTA funding, and the assistance of…

  6. Mi Casa es Su Casa: how an intracellular symbiont manipulates host biology.

    Science.gov (United States)

    Bhattacharya, Tamanash; Newton, Irene L G

    2017-10-27

    Wolbachia pipientis, the most common intracellular infection on the planet, infects 40% of insects as well as nematodes, isopods and arachnids. Wolbachia are obligately intracellular and challenging to study; there are no genetic tools for manipulating Wolbachia nor can they be cultured outside of host cells. Despite these roadblocks, the research community has defined a set of Wolbachia loci involved in host interaction: Wolbachia effectors. Through the use of Drosophila genetics, surrogate systems and biochemistry, the field has begun to define the toolkit Wolbachia use for host manipulation. Below we review recent findings identifying these Wolbachia effectors and point to potential, as yet uncharacterized, links between known phenotypes induced by Wolbachia infection and predicted effectors. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

  7. SENTIDOS DE DESACOLHIMENTO DE MÃES SOCIAIS DOS SISTEMAS DE CASAS LARES

    Directory of Open Access Journals (Sweden)

    Paulo André Sousa

    2015-04-01

    Full Text Available A institucionalização de crianças brasileiras é um fenômeno histórico. A presente pesquisa teve por objetivo problematizar os sentidos produzidos pelas mães sociais de uma casa de acolhimento no que diz respeito ao desligamento das crianças em situação de acolhimento prolongado, sendo realizada em uma ONG que trabalha com o sistema "Casa Lar". A coleta de dados foi efetuada a partir de um grupo focal, com o uso de um roteiro de entrevista semiestruturado. Os dados foram interpretados com base na análise semiótica, sendo centrais os conceitos de "Produção de Sentidos" e "Práticas Discursivas". Os sentidos construídos pelas mães sociais em relação às crianças e, principalmente, ao seu desligamento, alternam entre sentimentos maternais, até conclusões pessimistas quanto ao futuro desses jovens, fazendo da contradição, da incerteza e do afeto as marcas da vivência de tais profissionais.

  8. Socioeconomic residential segregation and public housing policies. An approach from the Program “Mi Casa, Mi Vida”. Case study in the city of Cordoba, Argentina

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    Florencia Molinatti

    2016-07-01

    Full Text Available This paper aims to analyze the possible effects of the housing program “Mi Casa, Mi Vida” in socioeconomic residential segregation in the city of Córdoba (Argentina. These effects are estimated from the study of the socioeconomic residential composition (before and after the implementation of the program, the mapping of residential movements generated by the program and the application of bivariate autocorrelation techniques. Among the key findings, most of the program beneficiaries are concentrated in poor areas surrounded by others in similar conditions. This fact favors the existence of a large cluster of poverty in the peripheries of the city and promotes marginalization and social exclusion.

  9. Casa Morpain

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    Parent, Claude

    1962-03-01

    Full Text Available Una casa fin de semana construida en las cercanías de París, en Fontainebleau. Es un proyecto de acusada personalidad, lo que nos lleva a prestarle una atención especial. Ha sido construida en una parcela con mediano desnivel, bien orientada, de fácil acceso y preciosas vistas sobre el Sena y el bosque que se extiende a lo largo de la orilla opuesta.

  10. A Casa Grande de Romarigães, um legado arquitectónico e literário de Aquilino Ribeiro

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    Maria Ribeiro Machado Pedroso de Lima

    2017-12-01

    Full Text Available A Casa Grande de Romarigães terá servido de cenário literário a uma das mais simbólicas obras do escritor Aquilino Ribeiro: A casa grande de Romarigães. Sua estrutura arquitectónica foi classificada como Imóvel de Interesse Público em 1986, atribuição que ainda não derivou em nenhum estudo rigoroso sobre a sua evolução morfológica. Com base nas constantes descrições na obra de Aquilino Ribeiro, e do seu confronto com a documentação histórica entretanto encontrada (escrita e gráfica, em grande parte inédita, este trabalho de investigação propõe o desenho da evolução morfológica da casa ao longo dos tempos, bem como a enunciação da influência deste solar para a organização social, cultural e económica da aldeia de Romarigães.

  11. Casa Sombrilla

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    Franzen, Ulrich

    1963-05-01

    Full Text Available The building is sited on top of a hill, which commands a magnificent view over the river Connecticut. The house is organised on two floor levels and full use is made of the sloping ground. On the lower floor three bedrooms, a dressing room, bathrooms, washing facilities, wardrobes, stores and the boiler room have been located. The top floor includes the main living zone of the house, namely: living-drawing room, dining room, breakfast room, kitchen and services. The structure is metallic and most ingeniously contrived. The roof consists of nine inverted parasol shapes, interconnected by means of three jointed arches. In the top floor the ceilings are covered with Cyprus wood and the floor surface is oak. The house harmonises well with the surrounding scenery. Both the internal and external aspect of the house is richly impressive, this being enhanced by the great simplicity and originality of its design.Se halla emplazada en la cima de un monte, con magníficas vistas sobre el río Connecticut. Se distribuye en dos plantas, según exige la pendiente del terreno: La baja comprende: tres dormitorios, vestidor, baños, lavadero, guardarropas, almacén y sala de calefacción. La alta aloja la zona representativa de la casa: estar-salón, comedor, comedor de desayunos, cocina y aseo. La estructura es metálica y muy ingeniosa. La cubierta se compone de nueve «sombrillas» invertidas y enlazadas entre sí por medio de tres arcos-bisagras. Los techos son de ciprés y los pisos de roble, en el pabellón superior. El aspecto de la casa es armónico con el paisaje, de gran riqueza exterior e interior, y de gran sencillez y originalidad.

  12. Latino/a Students' Perceptions of Their Sense of Belonging at Kansas State University: Mi Casa Es Su Casa... or Is It Really?

    Science.gov (United States)

    Esquivel, Sonia

    2010-01-01

    This qualitative multiple case study explored the campus climate and sense of belonging of Latino/a undergraduate student participants at a predominately White university. Guided by the work of Hurtado and Carter (1997), relationships among several aspects of the college environment and sense of belonging were examined. In depth interviews…

  13. Casa Gold

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    Schürmann, Joachim

    1963-05-01

    entorpezcan la visión de la casa. La piscina es como una continuación de la sala de estar, a través del porche, al que se accede por dos puertas practicadas en el cerramiento de cristal, completamente diáfano, del salón.

  14. Casas publicadas

    OpenAIRE

    Téllez,Andrés

    2010-01-01

    A partir de el hecho de que las casas son las obras de arquitectura más publicadas, el autor analiza comparativamente las obras de este número a través de su categorización basada en cuatro puntos de vista: geografías o distribuciones interiores, transformaciones de obras existentes, localización rural o urbana y referentes previos.

  15. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.

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    Nicholas Redshaw

    Full Text Available The Transforming Growth Factor-β (TGF-β signaling pathway is one of the major pathways essential for normal embryonic development and tissue homeostasis, with anti-tumor but also pro-metastatic properties in cancer. This pathway directly regulates several target genes that mediate its downstream functions, however very few microRNAs (miRNAs have been identified as targets. miRNAs are modulators of gene expression with essential roles in development and a clear association with diseases including cancer. Little is known about the transcriptional regulation of the primary transcripts (pri-miRNA, pri-miR from which several mature miRNAs are often derived. Here we present the identification of miRNAs regulated by TGF-β signaling in mouse embryonic stem (ES cells and early embryos. We used an inducible ES cell system to maintain high levels of the TGF-β activated/phosphorylated Smad2/3 effectors, which are the transcription factors of the pathway, and a specific inhibitor that blocks their activation. By performing short RNA deep-sequencing after 12 hours Smad2/3 activation and after 16 hours inhibition, we generated a database of responsive miRNAs. Promoter/enhancer analysis of a subset of these miRNAs revealed that the transcription of pri-miR-181c/d and the pri-miR-341∼3072 cluster were found to depend on activated Smad2/3. Several of these miRNAs are expressed in early mouse embryos, when the pathway is known to play an essential role. Treatment of embryos with TGF-β inhibitor caused a reduction of their levels confirming that they are targets of this pathway in vivo. Furthermore, we showed that pri-miR-341∼3072 transcription also depends on FoxH1, a known Smad2/3 transcription partner during early development. Together, our data show that miRNAs are regulated directly by the TGF-β/Smad2/3 pathway in ES cells and early embryos. As somatic abnormalities in functions known to be regulated by the TGF-β/Smad2/3 pathway underlie tumor

  16. Casa - estudio de un escultor

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    Enzo Venturelli

    2017-05-01

    Full Text Available La nueva arquitectura, como las antiguas o simplemente anteriores, está ligada al concepto social de la época, a pesar de lo cual hay siempre una constante que debe mantenerse: el hombre vive dentro de la casa y, por consiguiente, es preciso que se le dé un carácter cálido, vivo, movido..., humano.

  17. Casas de altos en Concepción

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    Rodrigo Fischer Pérez

    1990-06-01

    Full Text Available La casa de altos es una construcción eminentemente urbana. Pareada junto a otras construcciones, va formando bordes continuos, cuyos primeros pisos son generalmente comerciales y los superiores habitacionales.

  18. EL ORO ES TRISTE

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    Jose María Corella Hurtado

    2012-01-01

    Full Text Available Esas narraciones eran las mismas cantaletas de mis abuelos, de mis tíos, de los negros y los mineros, contadas bajo las torrenciales noches de lluvia o bajo los indignos soles. Mi madre también relataba de memoria, como una cotorra y con la misma exactitud mientras realizaba los oficios domésticos, bien sean los de la barraca del puerto de Barbacoas o los de la casa de Pasto. Los barbacoanos de esa lejana generación, debieron soportar los recuerdos nefastos de la historia enquistada con dolor porque crecieron coreando episodios con la misma y sorprendente precisión. Era, es y será por siempre, una carcoma dolorosa y perseverante, aquello de la draga. Es que lo sucedido en Barbacoas no debe olvidarse y menos repetirse. Esos sucesos me comprometían de alguna manera; vividos unos en carne propia y a oídas otros que mezclaban el dolor que causó a los paisanos la pobreza en que quedaron.

  19. Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response

    Science.gov (United States)

    Lipchina, Inna; Elkabetz, Yechiel; Hafner, Markus; Sheridan, Robert; Mihailovic, Aleksandra; Tuschl, Thomas; Sander, Chris; Studer, Lorenz; Betel, Doron

    2011-01-01

    MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-β signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area. PMID:22012620

  20. ¿Qué es Indoor airPLUS?

    Science.gov (United States)

    El Programa Interior de airPLUS es una asociación entre EPA, los constructores, raters, las utilidades, y organizaciones sanitarias e interiores ambientales de mejorar aire interior en nuevas casas casas verdes.

  1. The CASA Software Package

    Science.gov (United States)

    Petry, Dirk

    2018-03-01

    CASA is the standard science data analysis package for ALMA and VLA but it can also be used for the analysis of data from other observatories. In this talk, I will give an overview of the structure and features of CASA, who develops it, and the present status and plans, and then show typical analysis workflows for ALMA data with special emphasis on the handling of single dish data and its combination with interferometric data.

  2. CASA in invertebrates.

    Science.gov (United States)

    van der Horst, Gerhard; Bennett, Monique; Bishop, John D D

    2018-04-09

    Sperm movement has been described in several phyla of invertebrates. Yet, sperm motility has only been quantified using computer-aided sperm analysis (CASA-Mot) in externally fertilising species (broadcast spawners) of two phyla, molluscs and echinoderms. In the present study we quantified in detail the nature of the sperm tracks, percentage motility groupings and detailed kinematics of rapid-, medium- and slow-swimming spermatozoa in the oyster Crassostrea gigas and four species never previously studied by CASA-Mot, namely the molluscs Choromytilus meridionalis, Donax serra and Haliotis midae and the echinoderm Parechinus angulosus. A feature common to all these species are the helical tracks, the diameter of which seems to be species specific. Using CASA-Mot, the behaviour of spermatozoa was also studied over time and in the presence of egg water and Ca2+ modulators such as caffeine and procaine hydrochloride. For the first time, we show that hyperactivation can be induced in all species in the presence of egg water (sea water that was mixed with mature eggs and then centrifuged) and/or caffeine, and these hyperactivated sperm tracks were characterised using CASA-Mot. We relate the different patterns of sperm motility and behaviour to reproductive strategies such as broadcast spawning and spermcasting, and briefly review studies using CASA-Mot on other invertebrates.

  3. CASA Fact Sheet.

    Science.gov (United States)

    National Court Appointed Special Advocate Association, Seattle WA.

    Each year nearly 400,000 children in the United States are thrust into court through no fault of their own. Often these children also become victims of the United States' overburdened child welfare system. A Court Appointed Special Advocate (CASA) volunteer is a trained citizen who is appointed by a judge to represent the best interests of a child…

  4. A situação da lei na ótica da subjetividade: um estudo no vivido das crianças e jovens na Casa-Lar, Bela Vista - Vitória ES

    OpenAIRE

    Oliveira, Arlete Correa de

    2011-01-01

    Este trabalho questiona a lei, sob a ótica da subjetividade, no universo de crianças e jovens abrigados na Casa-Lar Bela Vista, Vitória, Espírito Santo. Sua temática central é a lei da proibição do incesto (EEP) e os complexos familiares (Lacan) cujos pressupostos teóricos orientam esta pesquisa e permitem explicitar a presença dessa lei na subjetividade humana e no laço social. Dentro desse questionamento, surge a importância da interface entre a assistência social e a explici...

  5. La construcción de un cielo: Casa Goycoolea

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    Rodrigo Lagos Vergara

    1995-12-01

    Full Text Available La casa se ubicará en una de las cuencas que deja el cerro Caracol a lo largo del río Bío-Bío en Concepción. El terreno es de dimensiones modestas y es un sitio entre medianeros que se encuentra dominado por vistas de las casas vecinas. La calle Los Copihues, hacia la que da el predio, es de tráfico limitado salvo los días de fiesta debido a que da acceso al Country Club de la ciudad. Esto determina que las únicas vistas apetecibles desde el sitio sean el horizonte de cerros, el cielo, y el acceso al Country Club, ya que por ese punto se abre el espacio y se accede.

  6. Ventaja de jugar en casa en voleibol de alto rendimiento

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    Rui Marcelino

    2009-01-01

    Full Text Available En este estudio se ha pretendido estudiar la ventaja en casa en el Voleibol de alto rendimiento, apoyándonos en las estadísticas de los partidos que más pueden explicar ese fenómeno. Se han analizado 65.949 acciones de juego seleccionadas de la Liga Mundial 2005. El instrumento de observación que se ha elaborado es una combinación de formato de campo con sistemas de categorías. Los datos se han obtenido mediante el "Volleyball Information System" y se han analizado mediante la prueba t de Student, y la prueba ji-cuadrado. Los resultados demuestran que hay ventaja en casa en Voleibol (57,5% de victorias jugando en casa. Las estadísticas del ataque (t= 2.49, p = 0.01, del servicio (t= -2.18, p= 0.03, de la recepción (t= 16.74, p<0.001 y de la distribución (t= 2.03, p= 0.04 muestran rendimientos superiores para los equipos que juegan en casa. No se han encontrado diferencias en el rendimiento del bloqueo (t= -0.25, p= 0.80 y la defensa (t= 0.11, p= 0.92 entre los juegos disputados en casa y los disputados fuera.

  7. Visión de las madres en el cuidado del hijo prematuro en el hogar Visão das mães no cuidado do filho prematuro em casa Vision of mothers in care of premature babies at home

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    Nubia Castiblanco López

    2011-07-01

    Full Text Available Objetivo: describir el significado que tiene para las madres cuidar el recién nacido prematuro en el hogar, desde su contexto cultural. Diseño: estudio de tipo cualitativo etnográfico basado en la teoría de Madeleine Leininger. Muestra: la información, obtenida de observación y 23 entrevistas a las madres en su hogar, se recolectó y se analizó según la entrevista y análisis etnográficos de James Spradley. Participantes: ocho madres de recién nacidos prematuros que asistieron a control al Programa Madre Canguro Integral, Hospital Universitario San Ignacio, entre noviembre de 2007 y mayo de 2008. Resultados: surgen dos temas: cuidados directos al recién nacido prematuro y el camino hacia la adaptación. El cuidado directo al recién nacido prematuro en el hogar significa para la madre cangurear, masajear, proteger del frío, alimentar al niño, mantener la higiene, conservar la protección del medio, dar amor, suministrar oxígeno suplementario al bebé si lo requiere y saber sobre las señales del niño. El camino hacia la adaptación materna tiene para las madres un objetivo: "criar el niño". Ellas manifiestan lo difícil que son las noches, expresan sus sentimientos y finalmente describen la adaptación materna como el acostumbrarse. Conclusión: la visión de las madres cuidando el recién nacido prematuro es universal: significa "cuidar mucho al niño" y estar pendientes; por otra parte, la connotación de cuidado es diversa porque cada madre lo cataloga, desde su propia percepción, como cuidado extremo, básico, esencial y especial. También las madres dejaron conocer creencias, valores, tradiciones y mitos.Objetivo: descrever o significado do cuidado do recém nascido prematuro em casa para as mães desde seu contexto cultural. Desenho: estudo de tipo qualitativo etnográfico baseado na teoria de Madeleine Leininger. Amostra: a informação obtida da observação e 23 entrevistas às mães em casa, a informação foi reunida

  8. La memoria y el registro de la Real Hacienda de Indias en la Casa de la Contratación (The memory and the record of the Royal Treasury in Indies in the Casa de la Contratación

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    Francisco Fernández López

    2015-03-01

    Full Text Available Resumen: Este artículo presenta, desde una perspectiva metodológica diplomática, la descripción y análisis de los libros de contabilidad que se llevaron en la Casa de la Contratación para el control administrativo y contable de la Real Hacienda. A estos efectos, mi objetivo es establecer el origen, naturaleza, formas y evolución, así como una clasificación de estos libros. Para el registro de las operaciones contables en esta institución se utilizaron, desde el momento de su creación en 1503, los libros de cargo y data. A mediados del siglo XVI aparecieron, además, los libros de arcas y los diarios y mayores de la partida doble.Abstract: This paper present, from a diplomatic methodological perspective, a description and analysis the accounting books of the Casa de la Contratación to the administrative and accounting control of the Royal Treasury in Indies. To this purpose, it is possible to demonstrate the origin, nature, formals requirements and evolution, together with a classification of these books. Transactions were recorded in the charge and discharge books, since 1503, and since the mid-sixteenth century in the books about arks and in the journals and the ledgers for double-entry bookkeeping.

  9. GERMINAÇÃO EM SEMENTES DE ESPÉCIES FLORESTAIS DA MATA ATLÂNTICA (LEGUMINOSEAE SOB CONDIÇÕES DE CASA DE VEGETAÇÃO GERMINATION OF SEEDS IN NATIVE FOREST SPECIES (LEGUMINOSEAE UNDER GREENHOUSE CONDITIONS

    Directory of Open Access Journals (Sweden)

    Adriane Oliveira Cunha

    2007-09-01

    Full Text Available

    O presente estudo teve como finalidade avaliar tratamentos pré-germinativos visando superar a dormência de sementes de quatro leguminosas arbóreas nativas da Mata Atlântica brasileira. O experimento foi conduzido sob ambiente de casa de vegetação, no Centro de Ciências Agrárias da Universidade Federal da Paraíba, em Areia-PB, Brasil. As espécies estudadas foram jatobá (Hymenaea courbaril L., guapuruvu [Schizolobium parahyba (Vell. Blake], orelha-de-negro [Enterolobium contortisiliquum (Vell. Morong] e madeira-nova [Peltophorum dubium (Spreng. Taub]. Os tratamentos consistiram em: T1 - escarificação lateral; T2 - escarificação lateral + embebição por 24 horas à temperatura ambiente; T3 - imersão em água a 50°C até esfriamento; T4 -imersão em água a 60°C até esfriamento; T5 - imersão em água destilada por 24 horas à temperatura ambiente; T6 - testemunha. A semeadura foi efetuada em bandejas, mediante a utilização do substrato areia. As características avaliadas foram emergência e índice de velocidade de emergência. Concluiu-se que sementes de jatobá submetidas à escarificação, seguida de embebição, exibem plântulas mais vigorosas. A escarificação sem embebição pode ser recomendada como tratamento pré-germinativo para sementes de orelha-de-negro. Seguida ou não de embebição, a escarificação foi também eficiente na quebra de dormência de sementes de guapuruvu. Quanto à dormência de sementes de madeira-nova, nenhum tratamento foi eficiente para superá-la.

  10. La Casa de Té como paradigma de la arquitectura en el espacio próximo

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    María Dolores Palacios

    2015-05-01

    Full Text Available La casa de Té es un ejemplo de arquitectura creada para ser percibida por la totalidad de los sentidos. Su ámbito es el espacio próximo, donde la totalidad de las cosas se encuentran al alcance de la mano. Nos habla del hombre y de la naturaleza y de la relación entre ambos.

  11. Status for CASA NOVA konsortiet

    DEFF Research Database (Denmark)

    Bonke, Sten

    1997-01-01

    The report reviews the development projects and the results hitherto achieved by the design and build organisation CASA NOVA which is one of four consortia within the R&D programme "Process and Product Development in Building", financed by the Ministry of Industry and the Ministry of Housing....

  12. Casa de parto: simbologia e princípios assistenciais Casa de parto: simbología y principios de asistencia Birth center: symbols and assistance -related principles

    Directory of Open Access Journals (Sweden)

    Luiza Akiko Komura Hoga

    2004-10-01

    Full Text Available A primeira Casa de Parto vinculada ao Programa Saúde da Família possui simbologia específica. Objetivou-se identificar os símbolos que permeiam as idéias, crenças, valores e práticas e os princípios que orientam a assistência prestada na Casa de Parto. O método de pesquisa foi a etnografia e a história oral temática, o recurso empregado para entrevistar enfermeiras obstétricas da Casa. Resultados: A Casa possui o valor simbólico da inovação da assistência ao parto e o cuidado humanizado à gestante é o princípio que norteia as práticas. Considerações finais: A simbologia da Casa e as práticas de cuidado desenvolvidas constituem referência às demais Casas de parto em proposição no Brasil e devem ser conhecidas pelas enfermeiras obstétricas.La primera Casa de Parto vinculada al Programa de Salud de la Familia posee simbología específica. El Objetivo de esta encuesta es identificar los símbolos que atraviesan las ideas, creencias, valores y prácticas así como los principios que orientan la asistencia de la casa de parto. El método de la encuesta fue la etnografía y la historia oral temática fue el recurso usado para entrevistar a enfermeras obstétricas de esta Casa. Resultados: La Casa posee el valor simbólico de la innovación de la asistencia al parto y el cuidado humanizado es el principio que orienta las prácticas de enfermería. Consideraciones finales: La simbología de la Casa y las prácticas de asistencia al parto desarrolladas en esta casa constituyen referencia de las demás casas de parto en Brasil y las deben conocer las enfermeras obstétricas.The first Birth Center of the Family Health Program has specific symbols. The purpose was the identification of symbols that permeate the ideas, beliefs, values, practices, and principles that guide the assistance given at the Birth Center. Ethnography was the research method; thematic oral history was the resource employed to interview obstetric nurses in

  13. Los procedimientos contables de Casa Boris: especial referencia al libro mayor (1872-1886)

    OpenAIRE

    José Paulo Cosenza; Carlos Antonio De Rocchi; Carlos Alberto Campello Ribeiro

    2014-01-01

    Boris Frères & Ltd. Co. (conocida popularmente como Casa Boris, denominación que se utiliza en este trabajo), durante ciento doce años tuvo un papel destacado en la economía de Ceará, una Provincia situada al Nordeste de Brasil. Este artículo examina los registros contables realizados en el Libro Mayor de la Casa Boris entre 1872 y 1886. El objetivo de este estudio es el de dar a conocer los hechos observados en el análisis del contenido de sus registros contables, con el fin de describir las...

  14. La casa Bermúdez-Samper, 1952-1960 Bogotá, Colombia

    Directory of Open Access Journals (Sweden)

    María Cecilia O’Byrne Orozco

    2010-12-01

    Full Text Available La casa Bermúdez, proyectada por Guillermo Bermúdez Umaña entre 1952 y 1960, es uno de los proyectos más conocidos y publicados de la arquitectura que se hizo en Bogotá durante la fecunda década de los años cincuenta del siglo XX. Este artículo propone una descripción de la casa a través de los documentos publicados con miras a entender y hacer explícito, desde los elementos, las partes y las relaciones que forman la arquitectura de la casa, el porqué de su fama.

  15. Casa para la playa, New Jersey

    Directory of Open Access Journals (Sweden)

    Breuer, Marcel

    1964-03-01

    Full Text Available The McMullan house, built on the beach, has been designed to be inhabited all the year round. Basically this building is a rectangular block, lifted above the dunes on a framework of timber columns and beams. The ground floor contains the entrance hall, the guest room or servant's quarters, including a bath room, and a shower room which can be reached separately from the beach. The second floor is taken up with the main living quarters, and the second floor contains the bedrooms. The northern and southern sides have few windows, whilst the eastern and western sides have balconies protected with sliding and Venetian blinds, which in addition to supplying an effective protection against the sun, give the house a pleasant sense of secluded intimacy. The blinds are made of wood, and are painted dark brown. Doors and windows are also made of wood, but painted white. This beautiful house on the New Jersey coast exhibits in a marked degree the sculptural quality of architecture, a three dimensional plasticity, which is often neglected in many buildings of the more simple kind. Marcel Breuer has succeeded in making each of the facades of this elementary boxlike design have an interest of its own, by playing with their colour, light and shade effects, texture and combination of materials.La casa McMullan, construida en la playa, está proyectada para ser habitada durante todo el año. En esencia es un bloque paralelepipédico, elevado sobre las dunas y sustentado por un sistema de columnas y vigas de madera vistas, tanto en el interior como en el exterior. Su planta baja alberga: la entrada principal, habitación de huéspedes o de servicio con baño y una ducha con acceso desde la playa. El primer piso agrupa las dependencias nobles. Y el segundo, la zona de dormitorios. Las fachadas norte y sur presentan pocos huecos al exterior; y las este y oeste disponen de galerías con persianas correderas y celosías, que, además de proporcionar intimidad a la

  16. CASA-MIA: A ''precision'' EAS detector

    International Nuclear Information System (INIS)

    Borione, A.; Cronin, J.W.; Covault, C.E.; Fick, B.E.; Gibbs, K.G.; Krimm, H.A.; McKay, T.A.; Mueller, D.; Newport, B.J.; Ong, R.A.; Rosenberg, L.J.; Catanese, M.; Green, K.D.; Matthews, J.; Nitz, D.F.; Sinclair, D.; van der Velde, J.C.; Kieda, D.

    1993-01-01

    The CASA-MIA detector was constructed to search for sources of UHE neutral radiation. As such it has established limits well below those of previously reported observations and of most contemporaneous detectors. In addition to its primary mission, however, CASA-MIA measures the lateral distribution of both electrons and muons in EAS throughout a range of energies and with a degree of sampling not previously available

  17. Casa de viviendas en Madrid

    Directory of Open Access Journals (Sweden)

    Lamela Martínez, Antonio

    1963-09-01

    Full Text Available This building occupies a site of 1990 sq. ms, and includes 29 apartments distributed in a semi ground floor, five standard floor levels, an attic and a double attic. The services have been located in a second basement, and the ground floor and first basement are being devoted to commercial uses, such as shops. In order to provide more free space for the commercial zone, the beginning of the stairs and the entry to the lifts is situated on the semi ground floor level. The porter's quarters, refuse reception cubicle and porter's hall have also been placed at this level. The basic nuclei of the apartments are clearly separated into zones daytime living quarters, night quarters and services. It is noteworthy that passages have been largely eliminated, and circulation problems have been otherwise solved, avoiding to some extent the crossing of the main lines of human circulation. The area devoted to social life has been increased as far as possible, and its environment has been enlarged by means of balcony-terraces. The fine aesthetic quality of the building, in its external aspect, is largely due to the clever way in which the materials have been used, exploiting their textures and combining these harmoniously.Ha sido construida sobre un solar de 1.991,41 m2 y consta de 29 viviendas distribuidas en cinco plantas- tipo, ático, doble ático y entreplanta. Los servicios generales de la casa están situados en el segundo sótano; la planta baja y el primer sótano albergan los locales comerciales. Para conseguir una mayor superficie en dichos locales se ha adoptado la solución de situar el arranque de escalera y ascensores en la entreplanta, donde, asimismo, aparecen ubicados los servicios de vigilancia, cuarto de recepción de basuras y vivienda del portero.

  18. CASAS: A Smart Home in a Box.

    Science.gov (United States)

    Cook, Diane J; Crandall, Aaron S; Thomas, Brian L; Krishnan, Narayanan C

    2013-07-01

    While the potential benefits of smart home technology are widely recognized, a lightweight design is needed for the benefits to be realized at a large scale. We introduce the CASAS "smart home in a box", a lightweight smart home design that is easy to install and provides smart home capabilities out of the box with no customization or training. We discuss types of data analysis that have been performed by the CASAS group and can be pursued in the future by using this approach to designing and implementing smart home technologies.

  19. CASAS: A Smart Home in a Box

    OpenAIRE

    Cook, Diane J.; Crandall, Aaron S.; Thomas, Brian L.; Krishnan, Narayanan C.

    2012-01-01

    While the potential benefits of smart home technology are widely recognized, a lightweight design is needed for the benefits to be realized at a large scale. We introduce the CASAS “smart home in a box”, a lightweight smart home design that is easy to install and provides smart home capabilities out of the box with no customization or training. We discuss types of data analysis that have been performed by the CASAS group and can be pursued in the future by using this approach to designing and...

  20. La distribución social de la tierra en el Bajo Miño (1600-1850, ¿Es posible el excedente campesino en comunidades minifundistas?

    Directory of Open Access Journals (Sweden)

    Pérez García, José Manuel

    2010-12-01

    polarization in a way that the dominant small farm went back a step but didn´t stop the consolidation and the enforcement of a privileged peasent minority able to accumulate, at the end of our overrun, a net surplus superior to the moderate income which this social model used to have.

    Con un uso cruzado de fuentes: inventarios post-mortem recogidos de 61 notarías de Pontevedra y Tuy y tres parroquias vaciadas de los libros reales del Catastro de Ensenada (326 explotaciones pretendemos adentrarnos en la sociedad del Bajo Miño a lo largo de casi tres siglos. Antes de proceder al análisis de esta sociedad propiamente dicha fue necesario pulir las fuentes manejadas, quizás la parte más laboriosa del presente trabajo y aproximarnos a la evolución de variables claves como las rentas, los rendimientos o la evolución de los cultivos para delimitar la relación entre el producto bruto y el producto neto medio por Ha. cultivada. La tendencia de la productividad neta por Ha. es de claro ascenso y al producirse esto en un contexto de estabilidad de la renta foral unido a la progresiva reducción de la semilla necesaria por la imposición creciente del maíz resulta que el mayor beneficiado del avance fuera el propio campesino explotador directo. El estudio evolutivo de la sociedad nos sitúa ante un modelo minifundista y deficitario en el siglo XVII en donde el modelo agrario, a pesar del éxito impositivo del maíz, fue incapaz de hacer frente al impetuoso avance de la población generando una gran marea de campesinos insuficientes necesitados de las necesarias salidas migratorias en la búsqueda de recursos complementarios. En el siglo XVIII, ahora en un cuadro de situación maltusiana y práctico estancamiento de la población, nuestra sociedad alcanza una especie de madurez y equilibrio sin que variasen de manera sustancial sus estructuras salvo pequeños avances y ello gracias a la emigración que alcanza sus topes y a un ganadería complementaria con un reparto m

  1. Residuos peligrosos hospitalarios en casa: una amenaza emergente.

    Directory of Open Access Journals (Sweden)

    Luz Divia Mejía-Reales

    2016-06-01

    Full Text Available Objetivo: describir el manejo de residuos peligrosos hospitalarios generados en los domicilios por usuarios con enfermedades crónicas de una institución prestadora de servicios de salud en la ciudad de Valledupar, Colombia. Materiales y Métodos: estudio de enfoque cuantitativo, la muestra estuvo conformada por 85 usuarios con enfermedades crónicas que cumplieran con los criterios de inclusión, a quienes se les aplicó un cuestionario sobre manejo de residuos peligrosos hospitalarios en casa. Resultados: la población encuestada estuvo expuesta a riesgos relacionados con el manejo de agujas un 40% de los diabéticos, el 55% de quienes padecen enfermedad renal, en contacto con líquido peritoneal, y los usuarios con enfermedad pulmonar obstructiva crónica 36% presentaron reacciones anafilácticas. Además se encontró que el 66% de la población no tiene conocimientos acerca del manejo de estos residuos, cuál es el almacenamiento, recolección, transporte, tratamiento y/o disposición final de los mismos. Conclusión: el estudio reveló que existe una problemática relacionada con el proceso integral de los residuos peligrosos hospitalarios, debido a que la población generadora de estos pertenecen a estratos medios - bajos y asumir la totalidad de los gastos generados es poco viable, además no está capacitada adecuadamente, por tal razón resultó pertinente la elaboración de un manual para el manejo de residuos peligrosos hospitalarios generados en casa, para instruir sobre actividades que realizan estos usuarios, buscando disminuir el impacto en la salud y el ambiente derivados de la producción de estos desechos.

  2. Study of the CASAS Relationship to GED 2002. Research Brief

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2003

    2003-01-01

    CASAS, in cooperation with the CASAS National Consortium Policy Council, conducted a study to provide guidance to program and instructional staff regarding student readiness to take the GED Tests. The study looked at the relationship of CASAS reading and math scores to official 2002 GED test results from five states--California, Hawaii, Iowa,…

  3. The Effectiveness of CASAs in Achieving Positive Outcomes for Children.

    Science.gov (United States)

    Litzelfelner, Pat

    2000-01-01

    Evaluated effectiveness of court-appointed special advocates (CASAs) in achieving positive outcomes for children in the child welfare system, using data from court and CASA program files on 200 children. Found that CASAs may have reduced the number of placements and court continuances children experienced. More services were provided to children…

  4. CASAS: An Effective Measurement System for Life Skills.

    Science.gov (United States)

    Stiles, Richard L.; And Others

    The California Adult Student Assessment System (CASAS) is a comprehensive educational system designed to enable adult educators to develop and evaluate a life skills curriculum for competency based educational programs. The system comprises the CASAS Competency List, the CASAS Item Bank, the User's Manual, the Curriculum Index and Matrix, and…

  5. Casa De La Solidaridad: A Pedagogy of Solidarity

    Science.gov (United States)

    Yonkers-Talz, Kevin

    2013-01-01

    Casa de la Solidaridad has been recognized as an innovative and effective educational model within Jesuit higher education yet, until now, there have only been verbal presentations of the unique attributes of the Casa de la Solidaridad model. In addition, there has been a lack of information regarding the influence of the Casa experience on the…

  6. Evolución de una casa

    Directory of Open Access Journals (Sweden)

    Mac L. Johansen, John

    1958-02-01

    Full Text Available La forma, aspecto, estructura, concepción y realización de una casa están en estrecha relación con el ambiente cultural, social y técnico que la rodean y con ellos evolucionan.

  7. CASA-Mot in mammals: an update.

    Science.gov (United States)

    Yániz, J L; Silvestre, M A; Santolaria, P; Soler, C

    2018-03-08

    Sperm motility is one of the most widely used parameters of sperm quality. Computer-aided sperm motility analysis (CASA-Mot) systems were developed to reduce the subjectivity of sperm motility assessment, and have had broad scientific and practical acceptance. In this review, the sources of variation and current applications of this technology and its relationships with other sperm quality tests are described in detail. Despite remarkable advances in the technique, there is still great need for standardisation in many species, and the numerous factors that affect the results make it difficult to provide universally accepted criteria for classifying semen samples based on sperm motility characteristics. The main fields for CASA-Mot include the study of male fertility and pathologies, evaluation of the effects of physical and chemical agents, improvement of epidemiological survey studies, more precise calculation of seminal doses for farm animals, realisation of basic studies about sperm function, improvement of sperm technologies such as cryopreservation and quality control analysis. Numerous relationships have been established between CASA-Mot and other sperm quality tests, although most of these parameters are complementary. Future CASA-Mot systems will probably be able to integrate several sperm quality parameters with motility.

  8. LA CIUDAD DESDE LA CASA: CIUDADES ESPONTÁNEAS EN LIMA

    Directory of Open Access Journals (Sweden)

    José García Calderón

    2010-01-01

    Full Text Available Los asentamientos informales en Lima surgen de la colocación de casas de estera en el desierto, en condiciones de precariedad y pobreza. Sin embargo, en estas siete décadas de existencia se han transformado en barrios relativamente integrados a la ciudad y con un considerable nivel de desarrollo. En esta investigación se describe cómo se ha generado un tejido urbano donde los procesos habituales de planificación, de la gran escala a la pequeña, de la ciudad a la casa (urbanización-parcelación-edificación se ven invertidos encontrando, en esta inversión, el mecanismo clave de su desarrollo. La casa de estera, en origen el único material para asentarse en el territorio, se convierte, más allá de un techo para sus ocupantes, en una estrategia para crear ciudad. La vivienda es taller o tienda, aportando esos usos al tejido urbano; cambia de funciones según las necesidades de los habitantes; crece a medida que se densifica el barrio, muta su tipología (de unifamiliar a colectiva o de carácter (de rural a urbana cuando el asentamiento pasa de pueblo a barrio. La casa crece al tiempo que crece la ciudad que forma; ambos se transforman mutuamente y esta simbiosis confiere al tejido su dinamismo y capacidad para evolucionar.

  9. Reacción constitucional producida por el extracto de polvo de casa

    Directory of Open Access Journals (Sweden)

    Enrique Drassinower H.

    1951-01-01

    Full Text Available 1° Hemos hecho una exposición general del polvo de casa, señalando que pertenece al grupo de los alergenos inhalantes no estacionales y hemos precisado que en nuestro medio es el alergeno inhalante más importante y el responsable más frecuente de las afecciones alérgicas del aparato respiratorio. 2° Hemos expuesto su composición, remarcando que su acción antigénica no depende de los alergenos inhalantes que entran como sus componentes, sino de un factor específico de alto poder antigénico, cuya naturaleza aún no ha podido ser precisada. 3° Somos partidarios de que el polvo de casa efectivamente posee acción antigénica y de que esta acción es debida a un factor específico. 4° Mencionamos que a favor de estos dos principios existen numerosas pruebas (entre las que destaca la de PRAUSNITZ-KÜSTNER o de la transmisión pasiva que demuestra la existencia de anticuerpos circulantes específicos, pero nos limitamos a señalar sobre todo los hechos de observación personal: Los benéficos efectos clínicos que hemos obtenido en nuestro medio con la desensibilización practicada tanto con extractos de polvo de casa autógenos como con extractos stock o mixtos. El estudio comparativo que hemos efectuado, tanto desde el punto de vista del diagnóstico como del tratamiento desensibilizante, entre los extractos de polvo de casa de la ciudad de Nueva York y los extractos de polvo de casa autógenos y stock de nuestro medio, nos ha permitido observar resultados sensiblemente iguales, lo que sin duda habla a favor de que la acción antigénica del polvo de casa es debida a un factor específico, el cual estaría presente en los tres extractos. Expusimos por último, que otra prueba concluyente a favor de la acción antigénica del polvo de casa lo constituye la reacción constitucional producida por el extracto de éste, y remarcamos lo infrecuente de estas reacciones con el extracto de polvo de casa. 5° Relatamos dos casos clínicos de

  10. Casa Neptuno- Hamburgo - Alemania Federal

    Directory of Open Access Journals (Sweden)

    Schramm, -

    1975-07-01

    Full Text Available The Neptune building, situated on one of the oldest piers of the port of Hamburg, is a structure of reinforced concrete, entirely designed for offices. It consists of ground floor, six further storeys and a basement with parking space and installations of the building. The facade, with rows of windows alternating with window boards of brick, is joined in vertical sections so as to adapt it to the dimensions of the old commercial buildings that are situated on the other side of the pier. Through the shape, dimensions and the materials used in the construction the building harmonizes perfectly with the surrounding environment.El edificio Neptuno, situado en uno de los más antiguos muelles del puerto de Hamburgo, es una construcción con estructura de hormigón armado, destinada en su totalidad a oficinas. Consta de planta baja, seis plantas superiores y un sótano de aparcamientos e instalaciones del edificio. La fachada, con bandas de ventanas alternadas con antepechos de ladrillo, está articulada en secciones verticales para adaptarla a las dimensiones de los viejos edificios comerciales que se encuentran al otro lado del muelle. El edificio, por su forma, dimensiones y materiales empleados en su construcción, armoniza perfectamente con, el entorno en el que se encuentra enclavado.

  11. A AFIRMAÇÃO DA CULTURA BRASILEIRA: DOS SERTÕES DA BAHIA ÀS METAMORFOSES DE CASAS-GRANDES E DE SENZALAS / The assertion of Brazilian culture: from the hinterland of Bahia to the metamorphoses of big houses and slave quarters

    Directory of Open Access Journals (Sweden)

    Afranio García

    2009-12-01

    Full Text Available Este artigo examina a contribuição de escritores ensaístas para a valorização da coletividade brasileira entre os anos de 1930 a 1960, substituindo a preocupação com a degenerescência de um povo de mestiços, pela objetivação da pesada herança histórica deixada pelo regime escravocrata das grandes plantações coloniais. Inicialmente é estudada a obra de Euclides da Cunha -Os Sertões- onde o significado do massacre de Canudos é amplificado por sua concepção como vinculado à liquidação do embrião de nova raça forte originada do cruzamento de brancos com índios. O estudo de três das obras fundamentais dos anos 30-40- Casa-grande e senzala de Gilberto Freyre, Raízes do Brasil de Sérgio Buarque de Holanda e Formação do Brasil Contemporâneo de Caio Prado Jr.- permite demonstrar como se objetivou a matriz social da mestiçagem no Brasil e o pesado legado deixado pela escravatura nos modos de funcionamento do espaço político, do campo econômico e na recriação das hierarquias sociais; sobretudo pelo exame desse legado sobre a “psicologia íntima” dos Brasileiros. São assim explicitados os desafios a serem enfrentados para consolidar a nação como uma democracia moderna e assegurar seu futuro autônomo.Palabras clave: Brasil; intelectuales; mesuizaje; cultura nacionalAbstractThis article investigates the contributions of intellectuals to the valorization of the Brazilian community during the years 1930-1940; substituting the objectivation of the heavy historical legacy inherited from the slavery system of large colonialplantations to the study of a miscigenated population. First this article reviews the book Os sertoes by Euclides da Cunha, where the signification of the war against the Canudos village is deciphered in terms of elimination of an emergingrace resulting from the cross-breeding of the Whites and the Indians. Then the study of three of the main works of the years 30-40, Casa Grande e Senzala (Masters

  12. Plan de viabilidad de una casa rural

    OpenAIRE

    Nieto González, Óscar

    2011-01-01

    Este proyecto consiste en la puesta en marcha de una casa rural en la localidad de Argés, próxima a la ciudad de Toledo, se llamará “La Casona de Argés”, la casa tendrá 4 habitaciones dobles y una suite, todas ellas con cuarto de baño y además de las estancias habituales como cocina y salón dispondrá de un semisótano destinado a zona de juegos, una piscina, y una amplia parcela acondicionada para juegos y disfrute de los huéspedes. El negocio va estar enfocado a un público que viaje con niños...

  13. Casa Veba en Dusseldorf - Alemania Federal

    Directory of Open Access Journals (Sweden)

    Hentrich, Helmut

    1977-03-01

    Full Text Available Designed for offices to be let, and made up of a buried part, occupying 6,500 m2 of the site, and a tower, cross-shaped plan, twelve storeys high. There are 200 parking spaces in the basement. The semibasement is occupied by part of the technical services of the house and a series of ancillary and supply quarters. Access to the building is through the ground floor, which comprises: rooms for meetings and lectures, electronic data processing installation and administrative offices. The offices to be let are distributed in the nine following floors. Finally, the coronation floor houses the remaining technical services of the building. In the main nucleus, vertical communication means have been arranged and the facilities of each floor. Construction has been performed by means of a reinforced concrete structure, with supports in the periphery of the building to leave the office areas free of obstacles. Flooring consists of ribbed slabs. Bracing against the wind is entrusted to the main nucleus, also of reinforced concrete. The building has a suitable series of technical installations, the varied range of measures adopted being worth mentioning, to achieve suitable sound-absorbing in each of the working premises.Está destinado a oficinas de alquiler, y se compone de un cuerpo enterrado, que ocupa los 6.500 m2 del solar, y una torre, de planta cruciforme, de doce alturas. En el sótano se han distribuido 200 plazas de aparcamiento. El semisótano lo ocupan parte de los servicios técnicos de la casa, y una serie de dependencias auxiliares y de suministro. El acceso al edificio es por la planta baja, que consta de: salas para reuniones y conferencias, instalación de elaboración electrónica de datos, y oficinas administrativas. En las nueve plantas siguientes se distribuyen las oficinas de alquiler. Por último, la planta de coronación aloja los restantes servicios técnicos del edificio. En el núcleo central se han dispuesto los medios

  14. Definición de un CRM para Casa Guatemala. Selección y adaptación de un CRM OpenSource para Casa Guatemala.

    OpenAIRE

    Iglesias Iglesias, Alberto

    2011-01-01

    El objetivo general de este proyecto es ayudar a las personas encargadas de dirigir y gestionar la institución, usando un sistema experto que, una vez alimentado con los datos necesarios, sea capaz de prever crisis económicas dentro de la institución, la calidad de vida de los niños, ayudar a gestionar el personal, tanto voluntariado como trabajadores, etc. En definitiva, ayudar y conseguir en la medida de lo posible la autosuficiencia de Casa Guatemala para tener un nivel d...

  15. SENSIBILIDADE DE Rhizoctonia solani Kuhn, A FUNGICIDAS “IN VITRO” E EM PLÂNTULAS DE ALGODOEIRO (Gossypium hirsutum L., EM CONDIÇÕES DE CASA DE VEGETAÇÃO SENSIBILITY OF Rhizoctonia solani Kuhn TO FUNGICIDES “IN VITRO” AND IN COTTON PLANTULES (Gossypium hirsutum L AT GREENHOUSE CONDITIONS

    Directory of Open Access Journals (Sweden)

    Wilson Ferreira de Oliveira

    2007-09-01

    Full Text Available

    Foram instalados nas dependências do Departamento Fitossanitário da Escola de Agronomia - UFG, ensaio “in vitro”, em BDA2 e a nível de Casa de Vegetação, objetivando testar a eficiência de diferentes dosagens de Iprodione + Thiran (Rovrin em comparação com PCNB (Brassicol 75 BR, TMTD (Rhodiauran 70 e Captan + Pencycuron (Monceren para o controle de Rhizoctonia solani Kuhn, na cultura do algodoeiro, através do tratamento de sementes. Os resultados obtidos, nas condições de realização dos ensaios, permitem concluir que os fungicidas Rovrin - 320 g.i.a., Monceren - 210 g.i.a., Rovrin - 240 g.i.a., Rovrin - 200 g.i.a., PCNB - 450 g.i.a./100 litros de água ou 100 kg de sementes mostraram-se eficientes e não diferiram estatisticamente entre si no controle de R. solani, enquanto que o produto TMTD (Rhodiauran 70 na dosagem de 280 g.i.a./100 litros de água ou 100 kg de sementes de algodoeiro não se mostrou eficiente no controle deste agente causal.

    Aiming to test the efficiency of different dosages of Iprodione + Thiram (Rovrin in comparison with PCNB (Brassicol 75 BR, TMTD (Rhodiauran 70 and Captan + Pencycuron (Monceren for controlling Rhizoctonia solani Kuhn, in cotton plantation, through seeds treatment, was mounted essays “in vitro” at greenhouse level and BDA, in the Phytosanitary Department annexes of School of Agronomy-UFG. The results obtained, at essays conditions, permit to conclude that fungicides Rovrin - 320 g.i.a., Monceren - 210 g.i.a., Rovrin - 240 g.i.a., Rovrin - 200 g.i.a., PCNB - 450 g.i.a./l00 liters of water or 100kg of seeds, were efficient and statistically had no variation among them, in controlling R. solani, while chemical product TMTD (Rhodiauran 70, at dosage of 280 g.i.a./100 liters of water or 100 kg of cotton seeds, was not efficient in controlling this causal

  16. Ewing's Sarcoma: An Analysis of miRNA Expression Profiles and Target Genes in Paraffin-Embedded Primary Tumor Tissue.

    Science.gov (United States)

    Parafioriti, Antonina; Bason, Caterina; Armiraglio, Elisabetta; Calciano, Lucia; Daolio, Primo Andrea; Berardocco, Martina; Di Bernardo, Andrea; Colosimo, Alessia; Luksch, Roberto; Berardi, Anna C

    2016-04-30

    The molecular mechanism responsible for Ewing's Sarcoma (ES) remains largely unknown. MicroRNAs (miRNAs), a class of small non-coding RNAs able to regulate gene expression, are deregulated in tumors and may serve as a tool for diagnosis and prediction. However, the status of miRNAs in ES has not yet been thoroughly investigated. This study compared global miRNAs expression in paraffin-embedded tumor tissue samples from 20 ES patients, affected by primary untreated tumors, with miRNAs expressed in normal human mesenchymal stromal cells (MSCs) by microarray analysis. A miRTarBase database was used to identify the predicted target genes for differentially expressed miRNAs. The miRNAs microarray analysis revealed distinct patterns of miRNAs expression between ES samples and normal MSCs. 58 of the 954 analyzed miRNAs were significantly differentially expressed in ES samples compared to MSCs. Moreover, the qRT-PCR analysis carried out on three selected miRNAs showed that miR-181b, miR-1915 and miR-1275 were significantly aberrantly regulated, confirming the microarray results. Bio-database analysis identified BCL-2 as a bona fide target gene of the miR-21, miR-181a, miR-181b, miR-29a, miR-29b, miR-497, miR-195, miR-let-7a, miR-34a and miR-1915. Using paraffin-embedded tissues from ES patients, this study has identified several potential target miRNAs and one gene that might be considered a novel critical biomarker for ES pathogenesis.

  17. Gamma-Ray Hold-up Measurements and Results for Casa 2 and Casa 3 at TA-18

    International Nuclear Information System (INIS)

    Desimone, David J.; Vo, Duc Ta

    2016-01-01

    Numerous critical assembly experiments were performed at TA-18 beginning in the 1940's. Several buildings, Casa 2 and Casa 3, were constructed to house these experiments. All gamma-ray hold-up measurements and analysis were performed for Casa 2 and Casa 3 in November/December 2015 to support decommissioning and demolition of the facilities. A technique called room hold-up was used to measure the nuclear materials. A grid pattern was laid out on the large room floor approximately every 9-10 feet. A three- to five-minute measurement was taken with a high-purity germanium (HPGe) detector at each location. Also, several measurements were taken in two storage vaults of Casa 3. A calibration check of the detectors showed that the efficiency and energy scale were stable. The final results of the hold-up measurements for Casa 2 and 3 are given.

  18. Mobile Motion Capture--MiMiC.

    Science.gov (United States)

    Harbert, Simeon D; Jaiswal, Tushar; Harley, Linda R; Vaughn, Tyler W; Baranak, Andrew S

    2013-01-01

    The low cost, simple, robust, mobile, and easy to use Mobile Motion Capture (MiMiC) system is presented and the constraints which guided the design of MiMiC are discussed. The MiMiC Android application allows motion data to be captured from kinematic modules such as Shimmer 2r sensors over Bluetooth. MiMiC is cost effective and can be used for an entire day in a person's daily routine without being intrusive. MiMiC is a flexible motion capture system which can be used for many applications including fall detection, detection of fatigue in industry workers, and analysis of individuals' work patterns in various environments.

  19. Análisis de Clima Organizacional de Baltimore Spice C.A.S.A.

    OpenAIRE

    Wong Carranza, Henry Paul

    2004-01-01

    Tesis de maestría -- Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas con énfasis en Gerencia, 2004 El objetivo general del trabajo es realizar un diagnóstico de los elementos que inciden e impactan negativamente en el desempeño del clima organizacional de Baltimore Spice C.A.S.A., que se ven reflejados directa e indirectamente en el rendimiento de los colaboradores en el nivel operativo. La organi...

  20. Viviendo Con Incendios: Una guia para los duenos de casas en Nuevo Mexico [Living with Fire: A Guide for the Homeowner-New Mexico

    Science.gov (United States)

    U.S. Department of the Interior Bureau of Land Management

    2008-01-01

    La posibilidad de perdidas humanas y de propiedad en Nuevo Mexico debido a un incendio forestal ha ido incrementando. Para responder a este peligro, entidades locales, estatales, federales, particulares y sin fines de lucro se han unido para crear Como Reducir la Amenaza de Incendios Forestales, un programa dirigido a los propietarios de casas. Este no es un programa...

  1. Los procedimientos contables de Casa Boris: especial referencia al libro mayor (1872-1886

    Directory of Open Access Journals (Sweden)

    José Paulo Cosenza

    2014-12-01

    Full Text Available Boris Frères & Ltd. Co. (conocida popularmente como Casa Boris, denominación que se utiliza en este trabajo, durante ciento doce años tuvo un papel destacado en la economía de Ceará, una Provincia situada al Nordeste de Brasil. Este artículo examina los registros contables realizados en el Libro Mayor de la Casa Boris entre 1872 y 1886. El objetivo de este estudio es el de dar a conocer los hechos observados en el análisis del contenido de sus registros contables, con el fin de describir las prácticas contables utilizadas por esta empresa de comercio en la conducción de sus negocios. Además, quisimos identificar los aspectos contables considerados relevantes y de interés para la historia de la contabilidad brasileña que explican la realización de las actividades mercantes desarrolladas por la Casa Boris en la Provincia de Ceará y en las ciudades vecinas. Los resultados del estudio ponen de manifiesto que los registros contables de la Casa Boris son transparentes, a punto de evidenciar y ayudar a explicar las transacciones económicas realizadas por dicha empresa según el marco comercial de la época y también, para poner de manifiesto el contexto histórico de la contabilidad durante la segunda monarquía brasileña, además de mostrar la coexistencia de un mercado provincial incipiente basado en una red de comercio uniendo Brasil y Europa.

  2. CASA: tracking the past and plotting the future.

    Science.gov (United States)

    Gallagher, M T; Smith, D J; Kirkman-Brown, J C

    2018-05-29

    The human semen sample carries a wealth of information of varying degrees of accessibility ranging from the traditional visual measures of count and motility to those that need a more computational approach, such as tracking the flagellar waveform. Although computer-aided sperm analysis (CASA) options are becoming more widespread, the gold standard for clinical semen analysis requires trained laboratory staff. In this review we characterise the key attitudes towards the use of CASA and set out areas in which CASA should, and should not, be used and improved. We provide an overview of the current CASA landscape, discussing clinical uses as well as potential areas for the clinical translation of existing research technologies. Finally, we discuss where we see potential for the future of CASA, and how the integration of mathematical modelling and new technologies, such as automated flagellar tracking, may open new doors in clinical semen analysis.

  3. Critical Pedagogy and Its Application to Health Education: A Critical Appraisal of the Casa en Casa Model.

    Science.gov (United States)

    Merideth, Emily

    1994-01-01

    Casa en Casa, a popular education project of an Oakland, California, community health clinic, has two key weaknesses: volunteers received little orientation to the role of health promoter, and promoters were given content knowledge without development of the skills needed to use it. (SK)

  4. De «La vivienda es mi derecho» a las «Ciudades armoniosas». La nueva comprensión del espacio habitable de UN-HABITAT

    OpenAIRE

    Goycoolea Prado, Roberto; Núñez Martí, Paz

    2009-01-01

    Análisis del alcance social y espacial de la evolución en el modo de entender el Derecho a la vivienda desde su incorporación en la Declaración de los Derechos Humanos en 1948. Entendido primero sólo como derecho a un cobijo sano y seguro, es hoy un elemento irrenunciable del Derecho a la Ciudad o a una vida digna en un entorno sostenible. Cambio conceptual cuya evolución y significado reflejan con claridad los lemas del Día Mundial del Hábitat. Instrumento de UN-HABITAT para exponer lo qu...

  5. CASA Uno GPS orbit and baseline experiments

    Science.gov (United States)

    Schutz, B. E.; Ho, C. S.; Abusali, P. A. M.; Tapley, B. D.

    1990-01-01

    CASA Uno data from sites distributed in longitude from Australia to Europe have been used to determine orbits of the GPS satellites. The characteristics of the orbits determined from double difference phase have been evaluated through comparisons of two-week solutions with one-week solutions and by comparisons of predicted and estimated orbits. Evidence of unmodeled effects is demonstrated, particularly associated with the orbit planes that experience solar eclipse. The orbit accuracy has been assessed through the repeatability of unconstrained estimated baseline vectors ranging from 245 km to 5400 km. Both the baseline repeatability and the comparison with independent space geodetic methods give results at the level of 1-2 parts in 100,000,000. In addition, the Mojave/Owens Valley (245 km) and Kokee Park/Ft. Davis (5409 km) estimates agree with VLBI and SLR to better than 1 part in 100,000,000.

  6. Casas-Ibarra parametrization and leptogenesis

    International Nuclear Information System (INIS)

    Xing Zhizhong

    2010-01-01

    The Casas-Ibarra parametrization is a description of the Dirac neutrino mass matrix M D in terms of the neutrino mixing matrix V, an orthogonal matrix O and the diagonal mass matrices of light and heavy Majorana neutrinos in the type-I seesaw mechanism. Because M D + M D is apparently independent of V but dependent on O in this parametrization, a number of authors have claimed that unflavored leptogenesis has nothing to do with CP violation at low energies. Here we question this logic by clarifying the physical meaning of O. We establish a clear relationship between O and the observable quantities, and find that O does depend on V. We show that both unflavored leptogenesis and flavored leptogenesis have no direct connection with low-energy CP violation. (authors)

  7. Casa do Alambique, estrutura rara e monumental

    OpenAIRE

    Cardoso, João Luís

    2014-01-01

    Uma intervenção arqueológica realizada em 2009 na Casa do Alambique, localizada na Quinta do Marquês de Pombal, em Oeiras, evidenciou a importância da produção de aguardente a partir da destilação do bagaço ou do vinho naquela quinta setecentista. O seu estudo, através da escavação e do registo, revelou assinaláveis cuidados técnicos, viabilizados por um já desenvolvido conhecimento científico, alicerçado no empirismo, conforme era usual na época. Trata-se de uma rara e monumental estru...

  8. miRSeqNovel

    DEFF Research Database (Denmark)

    Qian, Kui; Auvinen, Eeva; Greco, Dario

    2012-01-01

    We present miRSeqNovel, an R based workflow for miRNA sequencing data analysis. miRSeqNovel can process both colorspace (SOLiD) and basespace (Illumina/Solexa) data by different mapping algorithms. It finds differentially expressed miRNAs and gives conservative prediction of novel miRNA candidates...... with customized parameters. miRSeqNovel is freely available at http://sourceforge.net/projects/mirseq/files....

  9. PROGRAMA “CASA DAS GESTANTES”: UMA NOVA LÓGICA DE ATENÇÃO À SAÚDE MATERNA E PERINATAL

    OpenAIRE

    Adriano Maçal Pimenta; Juliana Vieira Nazareth; Kleyde Ventura de Souza

    2010-01-01

    El programa “Casa de las Embarazadas” es una estrategia del Ministerio de Salud Pública BR, teniendo en vista la equidad y humanización de la asistencia a las embarazadas de alto riesgo. Se trata de un estudio epidemiológico, transversal, descriptivo y exploratorio que se realizó en la “Casa de las Embarazadas” de una maternidad filantrópica en Belo Horizonte con el objetivo de evaluar el impacto de este programa en la salud materna de 292 embarazadas que usaron el servicio y de sus recién na...

  10. Ewing’s Sarcoma: An Analysis of miRNA Expression Profiles and Target Genes in Paraffin-Embedded Primary Tumor Tissue

    Directory of Open Access Journals (Sweden)

    Antonina Parafioriti

    2016-04-01

    Full Text Available The molecular mechanism responsible for Ewing’s Sarcoma (ES remains largely unknown. MicroRNAs (miRNAs, a class of small non-coding RNAs able to regulate gene expression, are deregulated in tumors and may serve as a tool for diagnosis and prediction. However, the status of miRNAs in ES has not yet been thoroughly investigated. This study compared global miRNAs expression in paraffin-embedded tumor tissue samples from 20 ES patients, affected by primary untreated tumors, with miRNAs expressed in normal human mesenchymal stromal cells (MSCs by microarray analysis. A miRTarBase database was used to identify the predicted target genes for differentially expressed miRNAs. The miRNAs microarray analysis revealed distinct patterns of miRNAs expression between ES samples and normal MSCs. 58 of the 954 analyzed miRNAs were significantly differentially expressed in ES samples compared to MSCs. Moreover, the qRT-PCR analysis carried out on three selected miRNAs showed that miR-181b, miR-1915 and miR-1275 were significantly aberrantly regulated, confirming the microarray results. Bio-database analysis identified BCL-2 as a bona fide target gene of the miR-21, miR-181a, miR-181b, miR-29a, miR-29b, miR-497, miR-195, miR-let-7a, miR-34a and miR-1915. Using paraffin-embedded tissues from ES patients, this study has identified several potential target miRNAs and one gene that might be considered a novel critical biomarker for ES pathogenesis.

  11. Don Alonso de Granada Venegas Rengifo, cuarto señor de la casa de Granada (1540-1611)

    OpenAIRE

    García Luján, José Antonio

    2014-01-01

    Limitada es la información que poseíamos hasta ahora sobre este conspicuo personaje. Sin embargo, un conjunto documental, disperso en varios archivos, ha posibilitado la realización de este artículo en el que se traza la biografía, hasta donde los documentos permiten, del que fuera titular de los mayorazgos y Casa de Granada desde 1565 hasta su fallecimiento en 1611. Sin duda, es su intervención en la rebelión morisca lo más conocido, que ahora se completa, al tiempo que se perfil...

  12. 78 FR 76050 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2013-12-16

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeron[aacute]uticas, S.A... rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain EADS CASA (Type...., Washington, DC. For EADS-CASA service information identified in this AD, contact EADS-CASA, Military...

  13. “La Casa de las Flores”: arquitectura urbana-manifiesto de Secundino Zuazo /

    Directory of Open Access Journals (Sweden)

    Duarte, Patricio; Gurovich, Alberto; Pavez, M.Isabel.

    2007-06-01

    Full Text Available La "Casa de las Flores" es un interesante proyecto de arquitectura urbana residencial -bloques de departamentos de alquiler- del arquitecto bilbaíno Secundino Zuazo Ugalde (tit. 1912, m. en 1970. Realizado entre 1930 y 1932, es uno de los tres conjuntos más representativos del Movimiento Moderno en Madrid, y fue declarado Monumento Nacional en 1981. En uno de los pisos de este conjunto residió el Premio Nobel de literatura Pablo Neruda.This is a remarkably housing project -apartments for rent- of Secundino Suazo. The building –National Monument since 1981- is representative of the Modern Movement of Madrid as well as a fine example of urban architecture. Pablo Neruda, the Chilean Nobel Prize in Literature, was a resident there.

  14. CASAS: Cancer Survival Analysis Suite, a web based application.

    Science.gov (United States)

    Rupji, Manali; Zhang, Xinyan; Kowalski, Jeanne

    2017-01-01

    We present CASAS, a shiny R based tool for interactive survival analysis and visualization of results. The tool provides a web-based one stop shop to perform the following types of survival analysis:  quantile, landmark and competing risks, in addition to standard survival analysis.  The interface makes it easy to perform such survival analyses and obtain results using the interactive Kaplan-Meier and cumulative incidence plots.  Univariate analysis can be performed on one or several user specified variable(s) simultaneously, the results of which are displayed in a single table that includes log rank p-values and hazard ratios along with their significance. For several quantile survival analyses from multiple cancer types, a single summary grid is constructed. The CASAS package has been implemented in R and is available via http://shinygispa.winship.emory.edu/CASAS/. The developmental repository is available at https://github.com/manalirupji/CASAS/.

  15. Casa Grande Ruins National Monument acoustical monitoring 2010

    Science.gov (United States)

    2014-11-01

    During September 2010, The Volpe Center collected baseline acoustical data at Casa Grande National Monument (CAGR), at one site for 28 days. The baseline data collected during this period will help park managers and planners estimate the effects of f...

  16. Mi sexualidad es una manifestación política y artística”. Ámbitos de la pospornografía en el México contemporáneo

    Directory of Open Access Journals (Sweden)

    José Antonio Romero López

    2018-03-01

    Full Text Available La pospornografía emergió como un movimiento político y artístico que llamaba a la reapropiación de la imagen pornográfica para visibilizar otras identidades, cuerpos, prácticas y placeres sexuales fuera del espectro heterosexual masculino que históricamente ha dominado en la pornografía de consumo masivo. La nota de investigación versa sobre los hallazgos y resultados que surgieron tras las entrevistas entabladas con doce artistas y activistas que han desarrollado su trabajo en torno a la pospornografía, dentro del contexto espacial-temporal del México contemporáneo. El propósito del texto es contribuir a la reflexión sobre las formas en que el posporno, como estrategia política de representación de la sexualidad, se ha empleado y comprendido en el contexto mexicano

  17. La casa de Halldor Gunnløgsson (1959. Una mirada a Oriente desde el Sund

    Directory of Open Access Journals (Sweden)

    Carmen García Sánchez

    2017-04-01

    Full Text Available La casa de Halldor Gunnløgsson, una de las obras más refinadas de la Edad de Oro de la arquitectura moderna danesa, es el resultado de una fuerte voluntad y disciplina artística personal. La cubierta plana, suspendida sobre una gran plataforma pavimentada –que continúa la construcción del lugar– tiene una gran presencia. En el interior, un espacio único, fluye libremente y se extiende al paisaje. Hay una extraordinaria sofisticación de la construcción vernácula; y una fuerte conexión con la arquitectura tradicional japonesa, revelada por el deseo de vivir en estrecho contacto con la naturaleza, la búsqueda del refinamiento mediante la moderación, la eliminación de los elementos superfluos y la preocupación por la luz y la sombra –estableciéndose un paralelismo con el oscuro invierno nórdico. Su característica abstracción es un ejemplo de modernidad. El edificio se acerca a la belleza clásica, por la aparición de proporción, simetría y orden, pero también por el tratamiento suave de las superficies de los materiales. Se reconoce un ritmo en diferentes dimensiones. Se valora la escala. Los colores aplicados o inherentes al material, alcanzan intensidad. La experiencia del espacio arquitectónico es global. Es una casa mágica y maravillosa.

  18. Casa Pruss. Buenos Aires - República Argentina

    Directory of Open Access Journals (Sweden)

    Álvarez, M. Roberto

    1974-12-01

    Full Text Available The building ¡s situated on a 910 m2 Lshaped site. It consists of three storeys and terrace: — in the basement are located: a garage with space for two cars, W.C., storage rooms and boiler room; — the ground floor comprises: hall-drawing room, dining-room and W.Cs. as well as the terraces; — the first floor contains: the family bedrooms, the staff bedrooms, the bathrooms and the laundry-and ironing room. A spiral staircase connects the three storeys and the terrace; another main staircase leads from the reception floor to the first. In front of as well as behind the house there is a garden. The structure is of metal with side walls and foundation of concrete. The remaining materials, interior as well as exterior, are of highest quality and easy to maintain.Está emplazada en una parcela de unos 910 m2, con forma de L. Consta de tres plantas y terraza: — el sótano comprende: un garaje para dos automóviles, aseo, almacenes y cuarto de calderas-máquinas; — en la baja se distribuyen: vestíbulo-salón, comedor de diario y servicios, además de las terrazas; — la planta primera agrupa: los dormitorios familiares, los de servicio, los baños y el cuarto de lavado y plancha. Una escalera curva comunica las tres plantas y la terraza; otra escalera, más aparente, enlaza la planta noble con la primera. Jardín delante y detrás de la casa. La estructura es metálica, con muros laterales y de fondo de hormigón. El resto de los materiales, en interiores y exteriores, son nobles y de fácil entretenimiento.

  19. Current perspectives of CASA applications in diverse mammalian spermatozoa.

    Science.gov (United States)

    van der Horst, Gerhard; Maree, Liana; du Plessis, Stefan S

    2018-03-26

    Since the advent of computer-aided sperm analysis (CASA) some four decades ago, advances in computer technology and software algorithms have helped establish it as a research and diagnostic instrument for the analysis of spermatozoa. Despite mammalian spermatozoa being the most diverse cell type known, CASA is a great tool that has the capacity to provide rapid, reliable and objective quantitative assessment of sperm quality. This paper provides contemporary research findings illustrating the scientific and commercial applications of CASA and its ability to evaluate diverse mammalian spermatozoa (human, primates, rodents, domestic mammals, wildlife species) at both structural and functional levels. The potential of CASA to quantitatively measure essential aspects related to sperm subpopulations, hyperactivation, morphology and morphometry is also demonstrated. Furthermore, applications of CASA are provided for improved mammalian sperm quality assessment, evaluation of sperm functionality and the effect of different chemical substances or pathologies on sperm fertilising ability. It is clear that CASA has evolved significantly and is currently superior to many manual techniques in the research and clinical setting.

  20. House, a feminine noun: representating architectural spaces in Casa e Jardim and Casa Claudia in age the great magazines

    Directory of Open Access Journals (Sweden)

    Rafael Alves Pinto Junior

    2011-12-01

    Full Text Available The emergence of magazines focusing on architecture and aimed at the general public, such as Casa e jardim in the 1950s and Casa Claudia in the 1970s, represented the creation of a culture of living associated with domestic spaces and the values this space represents as a typological object after the second half of the 20th century. Among other things, it affirmed the values of the social roles of women and architecture as the depository of the attributes of privacy and intimacy: the locus of family, memory and affection. The magazines set the tone for representing the architectural space as an area for living, legitimizing behaviors while exercising an aesthetic pedagogy, ushering in a culture associated with living and establishing a source for imagined ways of building in Brazil. By affirming an image of civilization, both Casa e jardim and Casa Claudia became a benchmark for other periodicals devoted to this theme.

  1. La casa Harry Seidler – Australia

    Directory of Open Access Journals (Sweden)

    Seidler, Harry

    1970-12-01

    Full Text Available The steep slope of the site has been utilised by the architects, who are also the owners, to establish various floor levels, corresponding to separate environmental zones, and thus adapt closely the functional aspects of the building to the ground topography. The house has a rectangular planform, and internally there is a sunny part mainly used during daytime, and a more protected one, suitable for relaxation and gentle activity. The interior is restful, and provides excellent visual perspectives in all directions, whilst the decoration, illumination and materials have been most tastefully chosen.El fuerte declive que presentaba la parcela fue aprovechado por los arquitectos —que al mismo tiempo son propietarios— para crear diferentes niveles, y en ellos diversos ambientes, y lograr la máxima adaptación de la edificación a la topografía del terreno. La casa adopta en planta ima forma rectangular, y en su interior se pueden apreciar: una soleada zona en la que desarrollan sus moradores «usos y actividades diurnas», y una sombreada zona destinada a «usos pasivos, tranquilos». En su interior se respira una sensación de desahogo y de libertad visuales tanto en el sentido horizontal como en el vertical. En todo el conjunto, sus diseñadores han conseguido acertados efectos, con la iluminación, y con la textura y color de los materiales empleados.

  2. Pharmaco-miR

    DEFF Research Database (Denmark)

    Rukov, Jakob Lewin; Wilentzik, Roni; Jaffe, Ishai

    2014-01-01

    MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics......' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. These interactions can be described as triplet sets consisting of a miRNA, a target gene and a drug associated with the gene. We have developed a web server which...... links miRNA expression and drug function by combining data on miRNA targeting and protein-drug interactions. miRNA targeting information derive from both experimental data and computational predictions, and protein-drug interactions are annotated by the Pharmacogenomics Knowledge base (Pharm...

  3. El ingeniero científico o casa con dos puertas mala es de guardar

    OpenAIRE

    Javier Aracil

    2011-01-01

    Resumen: En este artículo se analiza el sentido de la locución ingeniero científico, a partir de una discusión de la especificidad de la ingeniería y de su método. Se parte del papel fundamental jugado por la técnica en la génesis del género humano, así como del de la ingeniería en la de la civilización. A continuación se analiza el método del ingeniero, y se comentan las aportaciones de Simon, Vaughn Koen y Vincenti a la caracterización de ese método, y asimismo las peculiaridades de los con...

  4. Horizonte construido. Transformación del paisaje en la Casa Huarte

    Directory of Open Access Journals (Sweden)

    Pablo Olalquiaga Bescós

    2014-02-01

    Full Text Available La Casa Huarte (Madrid, 1966 representa, ante todo, una actuación en el paisaje. Sus creadores, José Antonio Corrales y Ramón Vázquez Molezún, invirtieron un método utilizado en proyectos anteriores (Instituto en Herrera de Pisuerga, Residencia en Miraflores, Pabellón de Bruselas donde la edificación se adecuaba al medio y el paisaje donde se insertaba. Mediante una transformación topográfica Corrales y Molezún construyeron un lugar en el que el horizonte, entendido como el paisaje formado por el encuentro de planos donde converge nuestra mirada, fue modificado. Cuando esto ocurre se produce una alteración de la mirada del observador, se “construye” un nuevo horizonte visual que es en definitiva el horizonte de la arquitectura, en el que los límites están definidos por los distintos planos. En esta construcción del nuevo horizonte, en la creación de nuevas experiencias visuales, las esculturas y los árboles, situadas en las plataformas de los patios de la Casa Huarte, se convirtieron en referencias visuales que alteraban los ángulos de visión previamente establecidos por la arquitectura. Estas siluetas incorporan nuevos puntos de referencia en ese horizonte, proporcionando profundidad, perspectiva y una escala intermedia entre la intimidad del observador y la monumentalidad del infinito

  5. c-Myc Represses Tumor-Suppressive microRNAs, let-7a, miR-16 and miR-29b, and Induces Cyclin D2-Mediated Cell Proliferation in Ewing's Sarcoma Cell Line.

    Directory of Open Access Journals (Sweden)

    Masanori Kawano

    Full Text Available Myc oncogenic transcription factor is known to inhibit tumor suppressive microRNAs (miRNAs, resulting in greater expression of their target protein related to cell cycle, invasion or anti-apoptotic factors in human cancer cells. To explore possible oncogenic factors in Ewing's sarcoma (ES, we conducted microarray-based approach to profile the changes in the expression of miRNAs and its downstream mRNAs in five ES cell lines and human mesenchymal stem cells (hMSCs. Three miRNAs, let-7a, miR-16 and miR-29b were significantly down-regulated, whereas c-Myc and cyclin D2 (CCND2 were significantly up-regulated in all tested ES cells compared with hMSCs. To verify that let-7a, miR-16 and miR-29b were the targets of c-Myc in ES cell lines, we transfected siRNA against c-Myc and confirmed the coordinate up-regulation of let-7a, miR-16 and miR-29b through the repression of c-Myc. The ES cells transfected with c-Myc-siRNA and let-7a, miR-16 and miR-29b exhibited the inhibition of the cell cycle progression. The increased expression of let-7a, miR-16 and miR-29b resulted in the reduction of CCND2 protein expression. We also demonstrated that c-Myc-siRNA treatment of ES cells was associated with the decreased expression of CCND2 as a down-stream of three miRNAs. Furthermore, the introduction of let-7a, miR-16 and miR-29b in ES cells could inhibit the c-Myc-mediated up-regulation of CCND2 resulted in the prevention of cell cycle progression. In addition, the transfection of let-7a, miR-16 and miR-29b in ES cells suppressed tumor growth ex vivo treatment. These findings suggests that the up-regulation of c-Myc inhibited the expression of let-7a, miR-16 and miR-29b subsequently induced CCND2 expression in ES cells. The present study might identify a novel oncogenic axis that c-Myc regulates the expression of CCND2 via let-7a, miR-16 and miR-29b, leading to the development new therapeutic targets for ES.

  6. Archivo histórico de la Casa de Moneda

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    Boletín Cultural y Bibliográfico Banco de la República

    1996-09-01

    Full Text Available El Banco de la República posee una de las colecciones más interesantes a nivel histórico y económico del país: el archivo de la Casa de Moneda que data de 1620. Su descripción y clasificación se comenzó en 1991 teniendo como base la Historia de la Casa de Moneda, de Antonio Barriga Villalba -administrador de la Casa en los años cincuenta-, siendo la única obra que se ha publicado hasta la fecha. La clasificación se ha realizado con base en la Norma general para la descripción archivística elaborada por el Archivo General de la Nación.

  7. Establishing CASA as an evidence-based practice.

    Science.gov (United States)

    Lawson, Jennifer; Berrick, Jill Duerr

    2013-01-01

    In this article the authors examine the evidentiary status of the Court Appointed Special Advocates (CASA) program through a review of current research findings and a critical analysis of the study methodologies used to produce those findings. Due to the equivocal research findings and widespread methodological weaknesses (most notably selection bias) in the literature base, it is determined that there is not currently enough evidence to establish CASA as an evidence-based practice. In spite of the challenges to the feasibility of such research, a future research agenda is suggested that calls for the execution of large randomized controlled trials in order to produce findings that will inform a deeper understanding of CASA effectiveness in improving child outcomes.

  8. Trabajo y salud en la mujer: análisis comparativo de mujeres con trabajo remunerado y amas de casa

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    Mª E. ESCALERA IZQUIERDO

    2000-01-01

    Full Text Available El objetivo de este estudio es detectar y analizar las posibles diferencias en salud, tanto psicológica como física, en mujeres con roles múltiples y amas de casa en exclusiva. Todas ellas tenían hijas/os, pareja y bastantes, un trabajo remunerado. Además de las diferencias, se han estudiado otras variables con las que la salud pudiera estar relacionada como las condiciones de trabajo (tanto en el campo laboral como en el doméstico, familiares (afectivas y ayuda instrumental, la tensión entre roles y recursos (autoestima, conductas de salud y de riesgo, apoyo social, nivel educativo e ingresos. Los resultados mostraron que existía una gran diferencia en las variables que explicaban la salud de las mujeres según trabajasen o no fuera de casa y una tendencia hacia una mejor salud por parte de las mujeres con trabajo remunerado. Para ambos grupos las variables más relevantes para una mejor salud estuvieron relacionadas con las conductas de salud y de riesgo y la tensión entre roles. En las que trabajaban fuera de casa fueron muy significativas la autoestima y las variables relativas a sus roles familiares (relaciones con la pareja e hijos/as así como las condiciones del trabajo doméstico, por delante de las laborales.

  9. La madre dice: el dolor de mi bebé es mi dolor A mãe diz: a dor do meu bebê é a minha dor Mother Says: My Baby´s Pain is my Pain

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    ROSA YOLANDA MUNÉVAR TORRES

    2010-10-01

    Full Text Available Objetivo: describir los sentimientos de las madres y el apoyo social con el que cuentan cuando su recién nacido siente dolor. Metodología: estudio cualitativo, de pequeño alcance, con metodología etnográfica. Se realizaron 22 entrevistas en profundidad a 8 madres, con promedio de 2 a 4 por informante. La muestra fue la saturación de información seleccionada por pertinencia y adecuación; se utilizaron notas de campo y observación participante. Los datos se analizaron según la metodología de James Spradley. Resultados: el tema central fue: el dolor del recién nacido lo conocen, sienten y alivian las madres con apoyo familiar. El primer subtema (ya publicado: Las madres conocen y alivian el dolor del recién nacido, y el segundo: La madre siente el dolor del recién nacido y se apoya en su familia; está constituido por dos dominios: Preocupación, dolor y amor son sentimientos maternos frente al dolor del recién nacido. La familia y los amigos son clases de apoyo de la madre. Conclusiones: el dolor del neonato y el desconocimiento de la causa y forma acertada de aliviarlo producen estrés en la madre y estrechan la relación madre-hijo, toda vez que ella cree experimentar el mismo dolor que el hijo, quien le demanda protección y cuidado como respuesta de alivio, acción que es prioritaria frente a sus propios sentimientos y necesidades. Por tanto, la madre desea ser cuidada como ser humano que sufre, requiere de familiares y personas cercanas que le ofrezcan apoyo emocional expresado en la compañía y la confianza e información cuando solicita orientación, consejo o ayuda en la toma de decisiones, sin desconocer su contexto cultural; estos aspectos son coherentes con la teoría propuesta por Madeleine Leininger, por cuanto el punto de vista del mundo de la madre y los factores de la estructura social que incluye la relación familiar influirán en los significados, las expresiones y modos de cuidar a su hijo con dolor de acuerdo

  10. Casa de alta montaña

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    Heidi Wenger

    2017-06-01

    Full Text Available En Rosswald, dominando el valle del Ródano y a 1.800 m de altura, está situada esta pequeña vivienda, de construcción sencilla y línea graciosa, cuya misión es el procurar refugio y descanso a sus habitantes, que, según costumbre tradicional, pasan en la región un mínimo de dos meses al año.

  11. Computer-assisted sperm analysis (CASA): capabilities and potential developments.

    Science.gov (United States)

    Amann, Rupert P; Waberski, Dagmar

    2014-01-01

    Computer-assisted sperm analysis (CASA) systems have evolved over approximately 40 years, through advances in devices to capture the image from a microscope, huge increases in computational power concurrent with amazing reduction in size of computers, new computer languages, and updated/expanded software algorithms. Remarkably, basic concepts for identifying sperm and their motion patterns are little changed. Older and slower systems remain in use. Most major spermatology laboratories and semen processing facilities have a CASA system, but the extent of reliance thereon ranges widely. This review describes capabilities and limitations of present CASA technology used with boar, bull, and stallion sperm, followed by possible future developments. Each marketed system is different. Modern CASA systems can automatically view multiple fields in a shallow specimen chamber to capture strobe-like images of 500 to >2000 sperm, at 50 or 60 frames per second, in clear or complex extenders, and in information for ≥ 30 frames and provide summary data for each spermatozoon and the population. A few systems evaluate sperm morphology concurrent with motion. CASA cannot accurately predict 'fertility' that will be obtained with a semen sample or subject. However, when carefully validated, current CASA systems provide information important for quality assurance of semen planned for marketing, and for the understanding of the diversity of sperm responses to changes in the microenvironment in research. The four take-home messages from this review are: (1) animal species, extender or medium, specimen chamber, intensity of illumination, imaging hardware and software, instrument settings, technician, etc., all affect accuracy and precision of output values; (2) semen production facilities probably do not need a substantially different CASA system whereas biology laboratories would benefit from systems capable of imaging and tracking sperm in deep chambers for a flexible period of time

  12. Expression and evolutionary analyses of three acetylcholinesterase genes (Mi-ace-1, Mi-ace-2, Mi-ace-3) in the root-knot nematode Meloidogyne incognita.

    Science.gov (United States)

    Cui, Ruqiang; Zhang, Lei; Chen, Yuyan; Huang, Wenkun; Fan, Chengming; Wu, Qingsong; Peng, Deliang; da Silva, Washington; Sun, Xiaotang

    2017-05-01

    The full cDNA of Mi-ace-3 encoding an acetylcholinesterase (AChE) in Meloidogyne incognita was cloned and characterized. Mi-ace-3 had an open reading frame of 1875 bp encoding 624 amino acid residues. Key residues essential to AChE structure and function were conserved. The deduced Mi-ACE-3 protein sequence had 72% amino acid similarity with that of Ditylenchus destructor Dd-AChE-3. Phylogenetic analyses using 41 AChEs from 24 species showed that Mi-ACE-3 formed a cluster with 4 other nematode AChEs. Our results revealed that the Mi-ace-3 cloned in this study, which is orthologous to Caenorhabditis elegans AChE, belongs to the nematode ACE-3/4 subgroup. There was a significant reduction in the number of galls in transgenic tobacco roots when Mi-ace-1, Mi-ace-2, and Mi-ace-3 were knocked down simultaneously, whereas little or no effect were observed when only one or two of these genes were knocked down. This is an indication that the functions of these three genes are redundant. Copyright © 2017. Published by Elsevier Inc.

  13. Bartolomé de Las Casas: una mirada política de la encomienda

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    Edwin Camacho Quintero

    2008-01-01

    Full Text Available La gura de Bartolomé de Las Casas es problemática, oscila entre los extremos que ven en él un Santo militante en la causa de la humanidad o un demente guiado por complejos narcisistas más que por un sentido humanitario hacia los indios. Tras la maraña de interpretaciones, diatribas y apologías tejidas durante casi cinco siglos, su pensamiento ofrece terrenos aún inexplorados en espe - cial su última etapa de maduración al interior del iusnaturalismo salmantino. Desde esta perspectiva, su tratamiento del problema de la encomienda trasciende los aspectos morales para ofrecer una mirada política que tiene como supuesto la consolidación del Estado absolutista español, y la reproducción problemática de prácticas medievales en el gobierno de las Indias.

  14. ‘Una ventanita’: Vida cotidiana de las dueñas de casa y agencia de las máquinas tragamonedas en Chile

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    Francisco Olivos Ravé

    2012-07-01

    Full Text Available Este artículo intenta dar respuesta de forma etnográfica a la pregunta de cuál es el sentido que ocupan las máquinas tragamonedas y la agencia que estas tienen sobre la vida cotidiana de las dueñas de casa de un barrio de clase media baja en la comuna de San Bernardo, Santiago. Se descubre que el juego en las máquinas tragamonedas no constituye un momento extraordinario, sino que es parte de la rutina, pero a la vez permite una ruptura de la simultaneidad del tiempo libre con el de las labores del hogar que caracteriza a otras actividades como ver televisión. Sin embargo, gracias al enfoque de la teoría del actor red es posible observar que la agencia de las máquinas tragamonedas canaliza el escape de lo que significa la casa, es decir, de las responsabilidades y de los problemas familiares. Se genera, por otra parte, un encuentro de las dueñas de casa con su self. Asimismo, la agencia de las máquinas tragamonedas desencadena controversias en la familia volviéndola parte de la red que se forma en torno el juego. Finalmente, se plantea que las decisiones que se tomen en torno a la legislación sobre el juego deben tener en cuenta una traducción que permita comprender la lógica del juego en la vida cotidiana de las dueñas de casa y de los jugadores en general.

  15. Historia oral de una maloca sitiada en el Amazonas: Aspectos de la rebelión de Yarocamena contra la Casa Arana, en 1917

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    Roberto Pineda Camacho

    1989-01-01

    Full Text Available Basándose en fuentes en su mayor parte orales, comparadas, el autor construye la narración histórica: La rebelión de muchos grupos indígenas del Putumayo, trabajadores esclavos en la explotación del caucho, contra su opresor La Casa Arana; cuyo resultado final es la matanza de los caucheros, orquestada por el Ejército peruano.

  16. A casa em verso e prosa: Canções, poesias e subjetividade do conceito de casa

    OpenAIRE

    CORDEIRO, Nilson Da Rocha

    2015-01-01

    Ao iniciar estas reflexões sobre a moradia, buscamos destacar o aspecto basilar da casa – enquanto abrigo – para o desenvolvimento do indivíduo, da cidade e da sociedade. Com o objetivo de investigar as concepções de casa, como esse termo é percebido e qual a sua real importância na constituição do indivíduo, utilizamos como porta de acesso para esse universo as representações feitas sobre a casa e o lar encontradas em canções e poemas que abordam a temática, seja de forma explicita ou implíc...

  17. Pedro Ventura de Puga, último señor de la Casa de Fontefiz

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    Leirós de la Peña, Paz

    2007-12-01

    Full Text Available This paper is based on documentation from Casa de Fontefiz kept in the AHPOR. The documents cover the period from the sixteenth to nineteenth century and provide information about the patrimony of the house, its social position and the political activities of Pedro Ventura de Puga during the firts half of the nineteenth century. The first part is focused on the origin and evolution of patrimony, way of living, nobility abuses (including social and sexual aspects, and the difficulties to keep the social status. In the second part, Pedro Ventura plays the main role: his participation in the War of Independence and the building of the liberal state. He is a relevant character to undestand the adaptation of nobility to an age of political changes and social ad economical survivals. The defense of the constitution and his participation in the liberal regime is compatible with the maintenance of a economy based on the collection of taxes and nobility titles. Pedro Ventura is politically registered as a moderate liberalist.

    Este trabajo está basado en la documentación de la Casa de Fontefiz, conservada en al AHPOR. Los documentos abarcan desde el siglo XVI al XIX y nos aportan información sobre el patrimonio de la Casa, su posición social y las actividades políticas de Pedro Ventura de Puga en la primera mitad del siglo XIX. La primera parte se centra en el origen y evolución del patrimonio, modo de vida, abusos de la hidalguía en el plano social y sexual y las dificultades para mantener el stuatus social. La segunda parte tiene como protagonista a Pedro Ventura de Puga, su participación en la Guerra de la Independencia y en la construcción del estado liberal. Es una figura clave para entender la adaptación de la hidalguía a una época de cambios políticos y de pervivencias sociales y económicas. La defensa de la Constitución y la participación en el régimen liberal es compatible con el mantenimiento de una econocmía basada en

  18. 77 FR 5998 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2012-02-07

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A... proposed to correct an unsafe condition for the specified products. The MCAI states: EADS-CASA received... address this condition, EADS-CASA has developed an engine condition control cable P/N 35-56382-0005 with...

  19. 75 FR 68185 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

    Science.gov (United States)

    2010-11-05

    ... Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones Aeronauticas, S.A...) that were, at that moment, defined in issue C of EADS-CASA document DT-0-C00-05001. That document has... implementation of the revised Fuel Airworthiness Limitations contained in issue D of EADS- CASA document DT-0-C00...

  20. Iowa CASAS Pilot Project Reports: An Initial Evaluation of CASAS Effectiveness in Iowa's Adult Basic Education Programs.

    Science.gov (United States)

    Strom, Mary L.

    In fall 1992, the Iowa Department of Education began pilot tests of the Comprehensive Adult Student Assessment System (CASAS), an assessment system evaluating reading, math, and problem solving in a life skills context for adult remedial programs. This document provides reports from the nine community colleges that served as test sites, describing…

  1. Computer-aided sperm analysis (CASA) in the medical laboratory: CASA in diagnostic andrology and assisted conception.

    Science.gov (United States)

    Tomlinson, Mathew J; Naeem, Asad

    2018-03-21

    CASA has been used in reproductive medicine and pathology laboratories for over 25 years, yet the 'fertility industry' generally remains sceptical and has avoided automation, despite clear weaknesses in manual semen analysis. Early implementers had difficulty in validating CASA-Mot instruments against recommended manual methods (haemocytometer) due to the interference of seminal debris and non-sperm cells, which also affects the accuracy of grading motility. Both the inability to provide accurate sperm counts and a lack of consensus as to the value of sperm kinematic parameters appear to have continued to have a negative effect on CASA-Mot's reputation. One positive interpretation from earlier work is that at least one or more measures of sperm velocity adds clinical value to the semen analysis, and these are clearly more objective than any manual motility analysis. Moreover, recent CASA-Mot systems offer simple solutions to earlier problems in eliminating artefacts and have been successfully validated for sperm concentration; as a result, they should be viewed with more confidence in relation to motility grading. Sperm morphology and DNA testing both require an evidence-based consensus and a well-validated (reliable, reproducible) assay to be developed before automation of either can be of real clinical benefit.

  2. Plan de negocio para la creación de una casa rural casitas El Teu-Llar en la isla de Lanzarote

    OpenAIRE

    GONZALEZ JARA, MARIA CRISTINA

    2014-01-01

    [ES] El presente trabajo final de carrera tiene por objeto la realización de un plan de negocio para implantar una empresa dedicada al alojamiento rural en el municipio de Haría (Lanzarote). El nombre comercial de la misma será Casitas el Teu-Llar queriendo hacer presente en el nombre tanto la procedencia de la propietaria (Valencia) como el lema de la empresa que es sentirse en casa. Los servicios que proporcionará estarán divididos en tres líneas de negocio (alojamiento, restauración y ...

  3. ELEMENTOS GÓTICOS EN UNA CASA VACÍA DE CARLOS CERDA

    Directory of Open Access Journals (Sweden)

    Cristián Cisternas

    2010-04-01

    Full Text Available Este artículo es un análisis de la novela Una casa vacía (1996 del escritor chileno Carlos Cerda, basado en la identificación de elementos de imaginería gótica en distintos niveles de la obra. Se estudia el funcionamiento de estos elementos dentro del marco esencialmente realista de la obra, para intentar establecer los límites cruzados entre el testimonio, la historia oficial y sus metaforizaciones. La alegoría final que la obra novelesca construye en relación con la antigua casa de tortura y sus habitantes, se corresponde con el período final de la Dictadura Militar (1973-1989 y las prácticas de tortura realizadas por organismos de gobierno contra civiles. Sin embargo, también se trata de mostrar la dificultad del realismo testimonial para escribir una novela sobre la degradación y el sufrimiento de la sociedad chilena del período, sin caer en una ideología maniquea de la narración.This article is an analysis of Una casa vacía (1996, a novel written by the Chilean author Carlos Cerda. This analysis is based upon the identification of elements of the Gothic imaginary at different levels of this narrative. The functioning of these elements is studied within the basically realistic frame of the novel, in order to establish the permeable boundaries between testimonial narrative, the official history and its metaphorizations. The ultimate allegory that the novel builds around a former torture house and its inhabitants finds its correspondence with the final period of the Military Dictatorship (1973-1989 and the torture practices carried by Government Organizations against civilians. Nevertheless, this article tries to show the difficulty of testimonial realism in order to write a novel about the suffering and decadence of the Chilean society of the period, without succumbing to a Manichean concept of the narrative function.

  4. Casa de la juventud, en Stuttgart, Alemania

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    Ellsässer, Karl

    1966-06-01

    Full Text Available The project consists of three buildings, joined together. The main building houses woodwork and metalwork shops, photographic laboratories, ceramic workshop and various secondary installations, in the basement. The ground floor has a number of games' rooms a room for the youth leader, and the manager's flat. The top floor is occupied by the library, a hall for craftwork and services. A second building has a large assembly hall, a cafeteria bar, dining room, and drawing room on the ground floor. On the first floor there is a general hall, for showing films, lectures, and similar, with a capacity for 180 seated people. The third building includes the table tennis hall and a bicycle storage. Construction is diaphanous, simple, and of high class workmanship, in up to date styles and using modem materials.El conjunto construido consta de tres edificios unidos entre sí: El edificio principal alberga, en el semisótano, los talleres de carpintería y metalistería, laboratorio fotográfico, taller de cerámica, cuartos de las instalaciones, etc.; en la planta baja, una serie de salas de juegos, etc., el cuarto del jefe de la juventud, y vivienda del director; y en la planta alta, la biblioteca, un local para la práctica de labores manuales, etc. El edificio de la gran sala colectiva aloja, en su nivel inferior, un salón cafetería-bar, comedor, sala de dibujo; y en la primera planta, la sala para múltiples usos —proyección de películas, reuniones, etc.— con capacidad de 180 asientos. Finalmente el tercer edificio alberga la sala de ping-pong y un local para guardar bicicletas. La construcción es diáfana, agradable y está concebida y realizada con esmero, de acuerdo con las directrices y materiales más modernos.

  5. El silencio en la Casa de la Reina

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    María del Carmen Simón Palmer

    2013-07-01

    Full Text Available Durante el reinado de los Austrias se impusieron duras reglas de etiqueta en la Casa de la Reina. La llegada de éstas supuso la sumisión tanto de la reina como de sus meninas.Sin embargo, muchos de los escritos de esta época dan una falsa imagen de felicidad, de mujeres que asisten continuamente a fiestas y banquetes, aunque una lectura más atenta demuestra que lo hacen sólo como adorno. Un sentimiento de sumisión, de vida en cautiverio, de miedo a la maternidad, y de agobio por unas normas que regulan la conversación con los hombres, y cualquier gesto de las habitantes de la Casa de la Reina, incluido el matrimonio por conveniencia, se convierten en artífices del continuo silencio femenino.

  6. Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation.

    Directory of Open Access Journals (Sweden)

    Constance Ciaudo

    2009-08-01

    Full Text Available Embryonic stem (ES cells are pluripotent cells derived from the inner cell mass of the mammalian blastocyst. Cellular differentiation entails loss of pluripotency and gain of lineage-specific characteristics. However, the molecular controls that govern the differentiation process remain poorly understood. We have characterized small RNA expression profiles in differentiating ES cells as a model for early mammalian development. High-throughput 454 pyro-sequencing was performed on 19-30 nt RNAs isolated from undifferentiated male and female ES cells, as well as day 2 and 5 differentiating derivatives. A discrete subset of microRNAs (miRNAs largely dominated the small RNA repertoire, and the dynamics of their accumulation could be readily used to discriminate pluripotency from early differentiation events. Unsupervised partitioning around meloids (PAM analysis revealed that differentiating ES cell miRNAs can be divided into three expression clusters with highly contrasted accumulation patterns. PAM analysis afforded an unprecedented level of definition in the temporal fluctuations of individual members of several miRNA genomic clusters. Notably, this unravelled highly complex post-transcriptional regulations of the key pluripotency miR-290 locus, and helped identify miR-293 as a clear outlier within this cluster. Accordingly, the miR-293 seed sequence and its predicted cellular targets differed drastically from those of the other abundant cluster members, suggesting that previous conclusions drawn from whole miR-290 over-expression need to be reconsidered. Our analysis in ES cells also uncovered a striking male-specific enrichment of the miR-302 family, which share the same seed sequence with most miR-290 family members. Accordingly, a miR-302 representative was strongly enriched in embryonic germ cells derived from primordial germ cells of male but not female mouse embryos. Identifying the chromatin remodelling and E2F-dependent transcription

  7. Differential compaction mechanism for earth fissures near Casa Grande, Arizona.

    Science.gov (United States)

    Jachens, R.C.; Holzer, T.L.

    1982-01-01

    Precise gravity measurements indicate that earth fissures or tension cracks caused by ground-water withdrawal within a 10km2 area SE of Casa Grande are associated with relief on the buried interface between the alluvial aquifer and underlying bedrock. These relations suggest that the fissures are forming in response to localized differential compaction caused by localized variations of aquifer-system thickness. -from Authors

  8. CUIDANDO UN HIJO PREMATURO EN CASA: DEL TEMOR Y LA DUDA A LA CONFIANZA

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    Melva Patricia Ocampo González

    2014-01-01

    Full Text Available Ser madre es el resultado de un proceso que implica desarrollar una fuerte identidad maternal, este inicia en la gestación y abarca incluso los primeros meses de vida del hijo. Este proceso se nutre de la constante interacción madre-hijo. Para conocer las vivencias de las madres de niños prematuros que han requerido hospitalización, al asumir el cuidado de ellos en casa, se realizó un estudio fenomenológico con participación de diez madres. Los hallazgos indican que la separación de la diada durante la hospitalización impone limitaciones, que impiden que la mujer asuma con tranquilidad y alegría el nuevo rol. Es importante empoderar al personal de enfermería de las unidades neonatales para implementar estrategias de contacto temprano y continuo madre-hijo, que apoyen a las mujeres en el proceso de convertirse en madres.

  9. La madre dice: el dolor de mi bebé es mi dolor

    OpenAIRE

    ROSA YOLANDA MUNÉVAR TORRES; LUCY MUÑOZ DE RODRÍGUEZ

    2010-01-01

    Objetivo: describir los sentimientos de las madres y el apoyo social con el que cuentan cuando su recién nacido siente dolor. Metodología: estudio cualitativo, de pequeño alcance, con metodología etnográfica. Se realizaron 22 entrevistas en profundidad a 8 madres, con promedio de 2 a 4 por informante. La muestra fue la saturación de información seleccionada por pertinencia y adecuación; se utilizaron notas de campo y observación participante. Los datos se analizaron según la metodología de Ja...

  10. La Casa del Fascio di Como e le sue

    Directory of Open Access Journals (Sweden)

    Cristina Casero

    2010-01-01

    Full Text Available Giuseppe Terragni’s ‘Casa del Fascio’ in Como undoubtedly stands out as a masterpiece of Italian ‘Razionalismo’, though inflected according to the architect’s peculiar language. However, as rightly noted by Diane Ghirardo, a merely formal analysis of the building is not plausible. The underlying meaning and the very value of the ‘Casa del Fascio’ are fully perceivable only by taking into consideration the original project, without overlooking the opulent ‘decoration’ specifically intended as an integral part of the building. That includes Marcello Nizzoli’s photomechanical panels for the façade, built but never actually put in place, and Mario Radice’s works for the ‘Sala del Direttorio’ and the ‘Salone delle Adunate’, both destroyed in the immediate post-war; also worth mentioning are the decorative projects by the architect himself for the ‘Sala Federale’ and the room entitled to Gigi Maino. From such a perspective, the ‘Casa del Fascio’ appears under a renovated light, as a building of great functional value, but also as a very interesting communicational device.

  11. DANIEL MERRO JOHNSTON: EL AUTOR Y EL INTÉRPRETE. LE CORBUSIER Y AMANCIO WILLIAMS EN LA CASA CURUTCHET

    Directory of Open Access Journals (Sweden)

    Jorge Torres Cueco

    2011-11-01

    Full Text Available No hace mucho tiempo pudimos ver en la pantalla la película El hombre de al lado (Argentina, 2009 filmada en la Casa del Doctor Pedro Curutchet en Buenos Aires. También era su principal protagonista, pues el argumento gira alrededor de su inmarcesible presencia. La cámara de Mariano Cohn y Gastón Duprat nos muestran una sugestiva narración de la promenade architectural, sus atractivos espacios interiores, los juegos de luces y sombras otorgados por su brise-soleil y, también, su fragilidad ante las actuaciones poco respetuosas. Algunas imágenes nos recuerdan las tomas que Pierre Chenal hizo en Architecture d’Aujourd’hui (1930 con la colaboración del propio Le Corbusier, en esa escenificación de la promenade, entonces, por la villa Savoye. A este respecto Tim Benton insistía en la importancia del significado asociado a este deambular. La villa Stein mostraba diversas clases de naturaleza, en la villa Savoye el dominio de la arquitectura contra un medio antagonista, la naturaleza, que se hace presente desde el hueco con que finaliza el recorrido por la rampa. En la casa Curutchet nos encontramos un árbol ante el que se producen todos los desplazamientos: es una porción de naturaleza encerrada en un patio. Es casi una homotecia en relación con el parque ante el que se sitúa la casa y la metrópolis de Buenos Aires. Quizás haya también una reflexión entre el habitar y el trabajar en la gran ciudad, tan presente en el pensamiento de Le Corbusier. Estos son interpretaciones que no constituyen verdad alguna, sino asociaciones de ideas que no tienen más validez que retazos de memoria y que, en modo alguno, tratan de suplantar la realidad que se encuentra en la misma obra de arquitectura. Muy distinto es el objetivo de Daniel Merro. No nos ofrece una interpretación sobre esta obra, sino que nos relata cómo es interpretada una misma partitura cuyo pentagrama se tiende a lo largo de una rampa.

  12. An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma

    Directory of Open Access Journals (Sweden)

    Mosakhani Neda

    2012-03-01

    Full Text Available Abstract Background Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses to identify novel biomarkers. Method Microarray technology (array comparative genomic hybridization (aCGH and micro RNA arrays was used to screen and identify copy number changes and differentially expressed miRNAs of 34 and 14 passages, respectively. Incubated cells used for xenografting (Passage 0 were considered to represent the primary tumor. Four important differentially expressed miRNAs (miR-31, miR-31*, miR-145, miR-106 were selected for further validation by real time polymerase chain reaction (RT-PCR. Integrated analysis of aCGH and miRNA data was performed on 14 xenograft passages by bioinformatic methods. Results The most frequent losses and gains of DNA copy number were detected at 9p21.3, 16q and at 8, 15, 17q21.32-qter, 1q21.1-qter, respectively. The presence of these alterations was consistent in all tumor passages. aCGH profiles of xenograft passages of each series resembled their corresponding primary tumors (passage 0. MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression. These miRNAS were predicted to regulate many ES-associated genes, such as genes of the IGF1 pathway, EWSR1, FLI1 and their fusion gene (EWS-FLI1. Twenty differentially expressed miRNAs were pinpointed in regions carrying altered copy numbers. Conclusion In the present study, ES xenografts were successfully applied for integrated microarray analyses. Our findings showed expression changes of miRNAs that were predicted to regulate many ES associated genes, such as IGF1 pathway genes, FLI1, EWSR1, and the EWS-FLI1 fusion genes.

  13. Preventive conservation applied to "Casa dos Patudos" oil painting collection

    Directory of Open Access Journals (Sweden)

    Mafalda Fernandes

    2016-01-01

    Full Text Available The main objective of this work was the identification of specific risks affecting the collection of oil paintings in the historic house "Casa dos Patudos" (Alpiarça, Portugal and the development of mitigation strategies for the risks encountered. The methodology used was proposed by the Canadian Conservation Institute. The results showed that the main risks affecting this collection result from incorrect handling, increase in paint detachment due to the maintenance of paintings with paint lifting on display, occurrence of insect pests, high fluctuations in relative humidity and, excessive exposure to ultraviolet radiation. Several preventive conservation strategies to mitigate these risks are proposed.

  14. Casa en Sierra Morena Huarochirí, Perú

    OpenAIRE

    Doblado, Juan Carlos

    2014-01-01

    La horizontalidad en la conformación de esta casa busca acentuar su relación con el paisaje de la cordillera de Los Andes. Se organiza en dos volúmenes horizontales paralelos, desfasados y semitransparentes, que se clavan a la pendiente. Al interior, la vivienda se caracteriza por poder integrar sus espacios a través de mamparas corredizas. En el primer cuerpo se encuentran los espacios comunes, la cocina y dormitorios, mientras que en el segundo volumen se sitúan un estar familiar y los dorm...

  15. Casa Elina”: el encuentro como oportunidad

    OpenAIRE

    Saavedra, Caudia; Martinez Goya, Milagros

    2017-01-01

    El dispositivo “Casa Elina” nace en abril del año 2014, como un servicio integrado entre el Hospital Subzonal Especializado “Elina de la Serna de Montes de Oca” y la Subsecretaría de Salud Mental y Adicciones, ahora Subsecretaría de Determinantes Sociales de la Salud y la Enfermedad Física, Mental y de las Adicciones del Ministerio de Salud de la provincia de Buenos Aires. Surge con la impronta de ser un dispositivo innovador en relación al formato tradicional hospitalario, a la vez de encuad...

  16. Dos casas en el cerro Pochoco: Lo Barnechea, Chile

    OpenAIRE

    Carreño, Mario; Sartori, Piera

    2009-01-01

    A partir de la remodelación de una vivienda, se generan dos casas superpuestas que comparten el mismo volumen y una torre-terraza asomada a un cajón cordillerano en la periferia de la ciudad de Santiago. La dimensión vertical de la montaña aparece en los interiores, orientados hacia el suelo inmediato y las vistas lejanas. Starting with the renovation of a dwelling, two superimposed houses are generated that share the same volume, a tower-terrace leaning out of a mountain valley in the out...

  17. Recent results from the CASA-MIA experiment

    International Nuclear Information System (INIS)

    Matthews, J.

    1995-01-01

    Results from the CASA-MIA cosmic ray experiment are presented. I discuss the apparatus and its performance, including new results on the identification of the shadows of the sun and moon used to determine the angular resolution. Limits on the emission of 100 TeV γ-rays from the Crab Nebula are well below extrapolations from TeV observations. A search for diffuse γ-rays from the Galactic plane give limits approaching some recent predictions. copyright 1995 American Institute of Physics

  18. Plant remains of archaeological site Casa Vieja, Callango (Ica

    Directory of Open Access Journals (Sweden)

    José Roque

    2013-06-01

    Full Text Available A paleoethnobotanical study was carried out at the Middle Horizon archaeological site of Casa Vieja, located in Callango within the Lower Ica Valley. A total of 23 species were identified, all determined to be of the Magnoliopyta Division, 78 % (or 18 species were Magnoliopsid and 22% (or 15 species Liliopsid. The Fabaceae are the best represented family with 6 species. Most of the analyzed samples correspond to seeds of Gossypium barbadense “cotton”. Seventy percent of the species were probably used as food; 48% for artifact-making and construction and 52% for medicinal and curative purposes.

  19. Search for <mi>CP> Violation and Measurement of the Branching Fraction in the Decay <mi>D>0<mi>KS>0<mi>KS>0

    Energy Technology Data Exchange (ETDEWEB)

    Dash, N.; Bahinipati, S.; Bhardwaj, V.; Trabelsi, K.; Adachi, I.; Aihara, H.; Al Said, S.; Asner, D. M.; Aulchenko, V.; Aushev, T.; Ayad, R.; Babu, V.; Badhrees, I.; Bakich, A. M.; Bansal, V.; Barberio, E.; Bhuyan, B.; Biswal, J.; Bobrov, A.; Bondar, A.; Bonvicini, G.; Bozek, A.; Bračko, M.; Breibeck, F.; Browder, T. E.; Červenkov, D.; Chang, M. -C.; Chekelian, V.; Chen, A.; Cheon, B. G.; Chilikin, K.; Cho, K.; Choi, Y.; Cinabro, D.; Di Carlo, S.; Doležal, Z.; Drásal, Z.; Dutta, D.; Eidelman, S.; Epifanov, D.; Farhat, H.; Fast, J. E.; Ferber, T.; Fulsom, B. G.; Gaur, V.; Gabyshev, N.; Garmash, A.; Gillard, R.; Goldenzweig, P.; Haba, J.; Hara, T.; Hayasaka, K.; Hayashii, H.; Hedges, M. T.; Hou, W. -S.; Iijima, T.; Inami, K.; Ishikawa, A.; Itoh, R.; Iwasaki, Y.; Jacobs, W. W.; Jaegle, I.; Jeon, H. B.; Jin, Y.; Joffe, D.; Joo, K. K.; Julius, T.; Kahn, J.; Kaliyar, A. B.; Karyan, G.; Katrenko, P.; Kawasaki, T.; Kiesling, C.; Kim, D. Y.; Kim, H. J.; Kim, J. B.; Kim, K. T.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kinoshita, K.; Kodyš, P.; Korpar, S.; Kotchetkov, D.; Križan, P.; Krokovny, P.; Kuhr, T.; Kulasiri, R.; Kumar, R.; Kumita, T.; Kuzmin, A.; Kwon, Y. -J.; Lange, J. S.; Lee, I. S.; Li, C. H.; Li, L.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, D.; Lubej, M.; Luo, T.; Masuda, M.; Matvienko, D.; Merola, M.; Miyabayashi, K.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Mohanty, S.; Moon, H. K.; Mori, T.; Mussa, R.; Nakano, E.; Nakao, M.; Nanut, T.; Nath, K. J.; Natkaniec, Z.; Nayak, M.; Niiyama, M.; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Ono, H.; Pakhlov, P.; Pakhlova, G.; Pal, B.; Pardi, S.; Park, C. -S.; Park, H.; Paul, S.; Pedlar, T. K.; Pesántez, L.; Pestotnik, R.; Piilonen, L. E.; Prasanth, K.; Ritter, M.; Rostomyan, A.; Sahoo, H.; Sakai, Y.; Sandilya, S.; Santelj, L.; Sanuki, T.; Sato, Y.; Savinov, V.; Schneider, O.; Schnell, G.; Schwanda, C.; Schwartz, A. J.; Seino, Y.; Senyo, K.; Sevior, M. E.; Shebalin, V.; Shen, C. P.; Shibata, T. -A.; Shiu, J. -G.; Shwartz, B.; Simon, F.; Sokolov, A.; Solovieva, E.; Starič, M.; Strube, J. F.; Stypula, J.; Sumisawa, K.; Sumiyoshi, T.; Takizawa, M.; Tamponi, U.; Tanida, K.; Tenchini, F.; Uchida, M.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Usov, Y.; Van Hulse, C.; Varner, G.; Vorobyev, V.; Vossen, A.; Waheed, E.; Wang, C. H.; Wang, M. -Z.; Wang, P.; Watanabe, M.; Watanabe, Y.; Widmann, E.; Williams, K. M.; Won, E.; Yamashita, Y.; Ye, H.; Yelton, J.; Yook, Y.; Yuan, C. Z.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zhukova, V.; Zhulanov, V.; Zupanc, A.

    2017-10-01

    We report a study of the decay <mi>D>0<mi>KS>0<mi>KS>0 using 921 fb-1 of data collected at or near the Υ(4S) and Υ(5S) resonances with the Belle detector at the KEKB asymmetric energy e+e- collider. The measured time-integrated CP asymmetry is ACP(<mi>D>0<mi>KS>0<mi>KS>0) = (-0.02 ± 1.53 ± 0.02 ± 0.17)%, and the branching fraction is B(<mi>D>0<mi>KS>0<mi>KS>0) = (1.321 ± 0.023 ± 0.036 ± 0.044) × 10-4, where the first uncertainty is statistical, the second is systematic, and the third is due to the normalization mode (<mi>D>0<mi>KS>0π0). These results are significantly more precise than previous measurements available for this mode. The ACP measurement is consistent with the standard model expectation.

  20. eXtended CASA Line Analysis Software Suite (XCLASS)

    Science.gov (United States)

    Möller, T.; Endres, C.; Schilke, P.

    2017-02-01

    The eXtended CASA Line Analysis Software Suite (XCLASS) is a toolbox for the Common Astronomy Software Applications package (CASA) containing new functions for modeling interferometric and single dish data. Among the tools is the myXCLASS program which calculates synthetic spectra by solving the radiative transfer equation for an isothermal object in one dimension, whereas the finite source size and dust attenuation are considered as well. Molecular data required by the myXCLASS program are taken from an embedded SQLite3 database containing entries from the Cologne Database for Molecular Spectroscopy (CDMS) and JPL using the Virtual Atomic and Molecular Data Center (VAMDC) portal. Additionally, the toolbox provides an interface for the model optimizer package Modeling and Analysis Generic Interface for eXternal numerical codes (MAGIX), which helps to find the best description of observational data using myXCLASS (or another external model program), that is, finding the parameter set that most closely reproduces the data. http://www.astro.uni-koeln.de/projects/schilke/myXCLASSInterface A copy of the code is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/598/A7

  1. Los dos mundos en Casa Malaparte Isla de Capri, Italia

    Directory of Open Access Journals (Sweden)

    Gloria Saravia Ortiz

    2010-12-01

    Full Text Available En Casa Malaparte lo doméstico y lo monumental se encuentran para dar paso a una de las viviendas más interesantes, cuestionadas y sugestivas de la modernidad. Proyecto “singular” cuanto entra en directa relación con la imponente naturaleza del lugar, esta obra propone el sentido doméstico de una vivienda cotidiana y simultáneamente una idea de lo monumental, lo cual le otorga un carácter casi mítico. El artículo recorre esta casa y su particular espacialidad entre lo expuesto y lo oculto; una vivienda capaz de reflejar la personalidad y la experiencia en el exilio de su propietario, el escritor italiano Curzio Malaparte, quien buscaba habitar una residencia hermética que, a su vez, satisficiera su deseo de espacio. Bajo la luz y la amplitud del paisaje de Capri que recibe el solarium de la vivienda, dominando el mar, el arquitecto italiano Adalberto Libera propone simultáneamente la opacidad y el hermetismo de una obra que desvela la soledad y permanece en la memoria como ilustración de la cultura mediterránea.

  2. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  3. Collective memory and the Casa della Memoria : on the potential and risk of instant patina

    NARCIS (Netherlands)

    Black, S.E.; Jenniskens, D.P.H.

    2017-01-01

    This article investigates the way in which instant patina is employed in the Casa della Memoria (House of Memory) in Milan by Baukuh (2015), with reference to Maurice Halbwachs’s theory of collective memory. It observes that the Casa della Memoria uses instant patina with the aim of solidifying a

  4. Aligning CASAS Competencies and Assessments to Basic Skills Content Standards. Second Edition

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2009

    2009-01-01

    Since its inception, the Comprehensive Adult Student Assessment System (CASAS) has focused on teaching and assessing basic skills in contexts that are relevant and important to adult learners. CASAS has developed and continues to refine a highly formalized hierarchy of competencies, the application of basic skills that adults need to be fully…

  5. Casa de la Esperanza: A Case Study of Service Coordination at Work in Colorado.

    Science.gov (United States)

    Franquiz, Maria E.; Hernandez, Carlota Loya

    This chapter describes how a federally funded farmworker housing facility in northern Colorado--Casa de la Esperanza--has changed the lives of migrant students and their families. The history of migrant workers in Colorado is described, as well as the struggle to construct a permanent farmworker housing facility. Casa was built in Boulder County,…

  6. Casa de un arquitecto, en la Tour-de-Peilz (Suiza

    Directory of Open Access Journals (Sweden)

    Pythoud, René

    1966-09-01

    Full Text Available This building has two levels. One of them is a semibasement, which contains a bedroom, a playroom, a wash room, a wine celler, a laundry, a boiler room and a garage. The other level, above the ground, has a living room, a dining room, a kitchen, for bedrooms and services. The house has been very simply constructed, and is almost totally open to the surrounding landscape. Materials have been employed strictly for functional purposes. The interior furniture and decoration are also most simple and elegant.Esta construcción tiene dos niveles: uno, el de semisótano, que está ocupado por un dormitorio, cuarto de juegos, una ducha y W. C., bodega, lavadero, cuarto de calefacción y garaje; y otro, en nivel superior, que aloja la sala de estar, comedor, cocina, cuatro dormitorios y los servicios. La casa es de una gran sencillez constructiva, casi totalmente abierta al paisaje que la circunda, y en ella se han utilizado los materiales con noble y pura sinceridad. La decoración y mobiliario interior son, asimismo, sencillos y de una gran elegancia.

  7. Casa-estudio núm. 25, de Arts & Architecture, en Los Ángeles, (U. S. A.

    Directory of Open Access Journals (Sweden)

    Killingsworth – Brady - Smith, Arquitectos and Associate

    1966-10-01

    Full Text Available This house has two storeys, the lower one containing a large open vestibule and the living zone: dining room, kitchen, services and garage. The top floor has a study (which can be converted into a bedroom, if need be, a main and a secondary bedroom and two bathrooms. This house is notable in many senses, and defines a new and highly interesting design criterion.Desarrollada en dos plantas aloja, en la baja, un amplio vestíbulo abierto, la zona de vivir diurna, comedor, cocina, servicios y garaje. Y en la planta superior, un. Estudio— convertible en caso de necesidad en dormitorio—, dormitorio principal, un segundo dormitorio y dos baños. La casa es notable en muchos aspectos y marca una pauta interesante a seguir.

  8. Autoficción y trabajo de memoria en La casa de los conejos de Laura Alcoba

    Directory of Open Access Journals (Sweden)

    Bruno Ragazzi

    2013-11-01

    Full Text Available Este artículo se propone indagar acerca de las representaciones discursivas en el campo de memoria que se presentan en La casa de los conejos de Laura Alcoba. Se cree que la elección del género de la autoficción es una herramienta genérica que permite descubrir nuevas narrativas mnémicas en torno al enfrentamiento desigual entre Montoneros y las fuerzas represivas de la derecha. Estas novedosas maneras de ver el pasado se vinculan con lo que Ricoeur ha denominado “trabajo de memoria”, una elaboración terapéutica sobre el recuerdo que permite a un pueblo abrirse hacia la esperanza y el perdón.

  9. La denuncia a través de la mujer: La casa de la laguna, de Rosario Ferré

    Directory of Open Access Journals (Sweden)

    Ana Molestina

    2015-08-01

    Full Text Available La historia puertorriqueña es una historia de imposiciones identitarias, choques culturales y ambivalencia desde la llegada de los españoles a la isla. En La casa de la laguna, Ferré analiza el pasado  y el presente de Puerto Rico. Crea una reconstrucción simbolizada en la historia de las familias Mendizábal-Monfort, en la cual Isabel Monfort, trata de descubrir las causas del fracaso de su matrimonio. En esta búsqueda y reflexión personal, se representan las versiones olvidadas o silenciadas de la historia puertorriqueña y de igual manera, da voz y vida a las mujeres marginadas o silenciadas.

  10. MiDAS

    DEFF Research Database (Denmark)

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties...... of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge...... communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study...

  11. Mi palabra favorita. Una actividad con vídeo

    Directory of Open Access Journals (Sweden)

    Susana Cañuelo Carrión

    2012-08-01

    Full Text Available Mi palabra favorita es un actividad que surge a partir de la propuesta que realizael Instituto Cervantes con la web El día E (www.eldiae.es. Este portal fue creado enconmemoración del día del español, que se celebra desde 2009 el último sábado dejunio. Para festejar la vitalidad de la lengua y el interés mundial que despierta, hablantesy aprendientes de todo el mundo pueden explicar en dicho portal cuál es su palabrafavorita. Y pueden hacerlo con un texto, con un pictograma o con un vídeo.

  12. El uso del hierro en la Casa Milá de Barcelona

    Directory of Open Access Journals (Sweden)

    Vila Rodríguez, Rafael

    1990-08-01

    Full Text Available The materials and construction systems, even the conception of the general structure, were for Gaudí no more than mediums at the service of the formal and spatial expression of his architectural imagination. Sometimes, the use of certain materials was indiscriminate or without sufficient guarantees. The Casa Milá is a good example. The use of laminated iron in the Pedrera, which allowed Gaudí to conceive a story independent of the façades —wall-screens of stone which seem to defy the law of gravity—, have been, at the same time, the main cause of the deterioration of these façades. In the case of the structure, the conceptual solution based on the use of iron has responded well to the static needs. This has not occured with the solutions —no less ingeneous but too improvlsed and risky— foreseen, also based on iron, to hold up the façade. Here, the material, subjected to the effects of humidity —favored by the form given to the stone—, has not resisted the passage of time very well.

    Los materiales y los sistemas constructivos, incluso la concepción de la estructura general, no eran para Gaudí más que medios al servicio de la expresividad formal y espacial de su imaginativa arquitectura. A veces, la utilización de algunos materiales se hizo de forma indiscriminada o sin suficientes garantías. La Casa Milá es un buen ejemplo. La utilización del hierro laminado en la Pedrera, que permitió a Gaudí concebir una planta libre independiente de las fachadas —muros-cortina de piedra que parecen desafiar la ley de la gravedad—, ha sido, al mismo tiempo, la causa principal del deterioro de estas fachadas. En el caso de la estructura, la solución conceptual basada en el uso del hierro ha respondido bien a las solicitudes estáticas. No ha ocurrido así con las soluciones —no menos ingeniosas pero excesivamente improvisadas y arriesgadas— previstas, también en base al hierro, para la sustentación de la fachada. Aqu

  13. Treasury Offset Program (TOP) MI

    Data.gov (United States)

    Social Security Administration — The TOP MI helps OPSOS coordinate TOP case processing in the regions. The MI also helped communicate our progress and findings to BFQM and ORDP, as well as the ACOSS.

  14. Central and South America GPS geodesy - CASA Uno

    Science.gov (United States)

    Kellogg, James N.; Dixon, Timothy H.

    1990-01-01

    In January 1988, scientists from over 25 organizations in 13 countries and territories cooperated in the largest GPS campaign in the world to date. A total of 43 GPS receivers collected approximately 590 station-days of data in American Samoa, Australia, Canada, Colombia, Costa Rica, Ecuador, New Zealand, Norway, Panama, Sweden, United States, West Germany, and Venezuela. The experiment was entitled CASA Uno. Scientific goals of the project include measurements of strain in the northern Andes, subduction rates for the Cocos and Nazca plates beneath Central and South America, and relative motion between the Caribbean plate and South America. A second set of measurements are planned in 1991 and should provide preliminary estimates of crustal deformation and plate motion rates in the region.

  15. MicroRNA modulation induced by AICA ribonucleotide in J1 mouse ES cells.

    Directory of Open Access Journals (Sweden)

    Xiaoyan Shi

    Full Text Available ES cells can propagate indefinitely, maintain self-renewal, and differentiate into almost any cell type of the body. These properties make them valuable in the research of embryonic development, regenerative medicine, and organ transplantation. MicroRNAs (miRNAs are considered to have essential functions in the maintenance and differentiation of embryonic stem cells (ES cells. It was reported that, strong external stimuli, such as a transient low-pH and hypoxia stress, were conducive to the formation of induced pluripotent stem cells (iPS cells. AICA ribonucleotide (AICAR is an AMP-activated protein kinase activator, which can let cells in the state of energy stress. We have demonstrated that AICAR can maintain the pluripotency of J1 mouse ES cells through modulating protein expression in our previous research, but its effects on ES cell miRNA expression remain unknown. In this study, we conducted small RNA high-throughput sequencing to investigate AICAR influence on J1 mouse ES cells by comparing the miRNA expression patterns of the AICAR-treated cells and those without treatment. The result showed that AICAR can significantly modulate the expression of multiple miRNAs, including those have crucial functions in ES cell development. Some differentially expressed miRNAs were selected and confirmed by real-time PCR. For the differently expressed miRNAs identified, further study was conducted regarding the pluripotency and differentiation associated miRNAs with their targets. Moreover, miR-134 was significantly down-regulated after AICAR treatment, and this was suggested to be directly associated with the up-regulated pluripotency markers, Nanog and Sox2. Lastly, Myc was significantly down-regulated after AICAR treatment; therefore, we predicted miRNAs that may target Myc and identified that AICAR induced up-regulation of miR-34a, 34b, and 34c can repress Myc expression in J1 mouse ES cells. Taken together, our study provide a new mechanism for

  16. Aplicación de un programa de ludo motricidad para elevar el autoestima de las mujeres protegidas por la Fundación Casa de Refugio Matilde de la ciudad de Quito

    OpenAIRE

    Flores Culqui, Marcia Graciela

    2014-01-01

    Trabajo de investigación cuyo objetivo es establecer la incidencia de la aplicación del programa de ludo motricidad en los niveles de la autoestima de las mujeres protegidas por la Fundación Casa de Refugio Matilde, de la ciudad de Quito, mujeres víctimas de maltrato intrafamiliar. La violencia intrafamiliar es todo patrón de conducta asociada a un ejercicio de poder desigual que se manifiesta en el uso de la violencia física, psicológica, patrimonial, omisión y/o económica o sexual. Al menos...

  17. Colección permanente del Banco de la República. Biblioteca Luis Ángel Arango. Casa de Exposiciones

    Directory of Open Access Journals (Sweden)

    Benhur Sánchez Suárez

    1996-05-01

    Full Text Available Desde cuando dejé mi provincia natal y me radiqué en Bogotá, con mis sueños de artista y de escritor, la Biblioteca Luis Ángel Arango fue uno de mis polos de atracción. Y es algo muy simple de entender: por un lado mi ansiedad visual por todo lo que fuera pintura y, por otro, porque en sus salones se realizaron gran parte de las mejores exposiciones de la época - importancia que compartió con el Museo de Arte Moderno y algunas galerías privadas- y es casi obvio que hacia ellos dirigiera mi interés, como lo hicieran tantos colombianos amantes de las artes plásticas y creyentes de nuestro desarrollo cultural.

  18. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.

    Science.gov (United States)

    Ulbricht, Anna; Gehlert, Sebastian; Leciejewski, Barbara; Schiffer, Thorsten; Bloch, Wilhelm; Höhfeld, Jörg

    2015-01-01

    Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscles to degrade mechanically damaged cytoskeleton proteins. Moreover, repeated resistance exercise during 4 wk of training led to an increased expression of CASA components. In human skeletal muscle, CASA apparently acts as a central adaptation mechanism that responds to acute physical exercise and to repeated mechanical stimulation.

  19. Lo peculiar de los seres humanos no es la razón, sino la voluntad libre

    OpenAIRE

    PASCUAL F. MARTÍNEZ-FREIRE

    2015-01-01

    Mi tesis es que los seres humanos son agentes racionales pero no pueden ser definidos como los agentes racionales. Las ciencias cognitivas (psicología y neurociencia, y también la inteligencia artificial) nos dicen que algunos animales y algunas máquinas son asimismo agentes racionales. En mi opinión el rasgo más característico de mujeres y hombres no es su dimensión racional sino su dimensión volicional, es decir, su aspecto de ser agentes libres. Es precisamente en este aspecto volicional d...

  20. Mi-spillet

    DEFF Research Database (Denmark)

    Larsen, Lea Lund; Hejlesen, Stine

    2003-01-01

    MI-spillet er et undervisningsspil til folkeskolens mellemtrin og udskolingen. Spillet omformer Howard Gardners teori om de mange intelligenser til et praktisk og håndgribeligt værktøj til brug i folkeskolen. Spillet indeholder et undervisningsmateriale bestående af lærervejledning og kopimappe...... emnebaseret eller tværfagligt arbejde. Alt materialet ligger samlet på en cd-rom, hvorfra materialet printes. Skolen kan derfor ved køb af én cd-rom printe og producere et ubegrænset antal spil. Cd-rommen indeholder: 1. Lærervejledning 2. MI-spillet * Gulvpladerne * Spørgsmål til spillet * Bilag til...

  1. PROGRAMA “CASA DAS GESTANTES”: UMA NOVA LÓGICA DE ATENÇÃO À SAÚDE MATERNA E PERINATAL

    Directory of Open Access Journals (Sweden)

    Adriano Maçal Pimenta

    2010-01-01

    Full Text Available El programa “Casa de las Embarazadas” es una estrategia del Ministerio de Salud Pública BR, teniendo en vista la equidad y humanización de la asistencia a las embarazadas de alto riesgo. Se trata de un estudio epidemiológico, transversal, descriptivo y exploratorio que se realizó en la “Casa de las Embarazadas” de una maternidad filantrópica en Belo Horizonte con el objetivo de evaluar el impacto de este programa en la salud materna de 292 embarazadas que usaron el servicio y de sus recién nacidos (RN. Para tanto, fueran analizados datos del libro de registro de la institución. Los resultados hallados fueron positivos para la salud materna y perinatal: la mejoría clínica de las embarazadas que tuvieron el alta o evolucionaron para el parto en la maternidad y alta proporción de RN con apgar superior a 7. La planificación de la asistencia ofrecida y los índices maternos y perinatales favorables muestran que este programa es una buena estrategia para reducir la mortalidad infantil y materna, Objetivos del Milenio propuestos por la Organización de las Naciones Unidas.

  2. Quando as lembranças doem: a casa da infância em Vermelho amargo, de Bartolomeu Campos de Queirós

    Directory of Open Access Journals (Sweden)

    Marcela Verônica da Silva

    2016-01-01

    Full Text Available La última obra de Bartolomeu Campos de Queirós, la novela Vermelho Amargo (2011 es notable por su forma y contenido. La portada de la primera edición hecha por Cosac Naify, de color rojo oscuro y sin la vida que caracteriza a los tonos púrpura, anuncia el contenido doloroso de la narración, que es una mezcla de memorias en prosa poética y de escritura autobiográfica. Las imágenes de la infancia se abren como heridas mal curadas, y el lector tiene la oportunidad de desvelar el poder del verbo poético cuando se enfrenta directamente a estas llagas. En el presente artículo nos proponemos analizar la escritura autobiográfica y la memoria narrativa, con el fin de poner de relieve la imagen de la casa como construcción de la conciencia. Estos temas tienen el apoyo teórico de Gaston Bachelard especialmente en sus reflexiones sobre la poética del espacio relacionada con la primera casa, considerado lugar de formación de las subjetividades del ser.

  3. Cucurbitacées

    African Journals Online (AJOL)

    SARAH

    31 août 2015 ... Environ 58,17% des consommateurs des produits à base des graines de Cucurbitacées consomment régulièrement la sauce liquide simple de courge. Elle est obtenue par deux différentes méthodes selon les consommateurs. La première(A1) pratiquée par les 64,12% des consommateurs de cette sauce.

  4. Casa de acogida para mujeres víctimas de violencia de género en la ciudad de Villa Carlos Paz en Córdoba (Argentina)

    OpenAIRE

    Cortina Vicente, Eva Maria

    2016-01-01

    Treball final de Màster Universitari en Igualtat i Gènere en l'Àmbit Públic i Privat (Pla de 2013). Codi: SRM042. Curs acadèmic 2015-2016 El tema elegido para el proyecto de intervención del trabajo final del Máster de Igualdad y Género en el Ámbito Público y Privado con especialidad en violencia de género es el de la creación de una Casa de Acogida para mujeres víctimas de violencia de género en la ciudad de Villa Carlos Paz en Córdoba (Argentina). Es uno de los recursos conte...

  5. The politics of publication: Bartolomé de las Casas's 'the devastation of the Indies'

    Directory of Open Access Journals (Sweden)

    Rolena Adorno

    1993-07-01

    Full Text Available [First paragraph] The Devastation of the Indies: A Brief Account. BARTOLOMÉ DE LAS CASAS. Translated by Herma Briffault. Introduction by Bill M. Donovan. Baltimore: Johns Hopkins University Press, 1992. 138 pp. (Paper US$ 11.95 The 1992 Johns Hopkins University Press publication of Bartolom? de las Casas's The Devastation of the Indies: A Brief Account has been, I am told, a commercial success. Regrettably, it is a scholarly failure. The translation - a reprint of a 1974 version - is so inaccurate that it barely deserves to go by the name, and the introductory essay that accompanies it repeats the old clich?s and familiar misunderstandings that one commonly reads about Las Casas's life and work. The shortcomings of both the translation and the introduction could have been overcome by a deeper engagement with Las Casas's works and greater attention to basic information about sixteenth-century Spanish history.

  6. Galicia ja galeegid / Arturo Casas Vales ; interv. Jüri Talvet

    Index Scriptorium Estoniae

    Vales, Arturo Casas

    2002-01-01

    Galiitsia kirjandusteoreetiku ja luuletaja ja A. Casas Valesi (sünd. 1958) arvamus eesti ja galeegi kirjanduse ning kultuuri sarnasustest ja erinevustest, galeegi keele sotsiaalsest kohast ja kirjanduse arengust

  7. Casas y bodegas de Florida, San Ignacio, Ninhue, Ranquil y Coelemu

    Directory of Open Access Journals (Sweden)

    Gonzalo Cerda Brintrup

    1990-12-01

    A continuación presentamos algunos de estos ejemplos: Casa principal del Fundo "Las Lajuelas" de Florida; Vivienda en Ranquil; Bodega de vinos "El Roble" en las cercanías de Coelemu y una vivienda urbana de Ninhue.

  8. Crop adapted spray application (CASA) - precise and safe plant protection in fruit growing

    NARCIS (Netherlands)

    Doruchowski, G.; Balsari, P.; Marucco, P.; Zande, van de J.C.; Wenneker, M.

    2012-01-01

    The Crop Adapted Spray Application (CASA) system for orchards integrates disease detection based on reflectance imaging, crop identification with ultrasonic sensors, wind measurement and DGPS navigation. Through the automatic adjustment of spray application parameters according to the crop

  9. El sentido cultural del cuidado en casa del enfermo

    Directory of Open Access Journals (Sweden)

    Marina Sánches-Sanabria

    2008-12-01

    Full Text Available Esta investigación tiene un diseño cualitativo descriptivo, transversal para comprender las diferencias existentes en los conocimientos, actitudes y prácticas influidas por la percepción o sentido cultural de cuidar del cuidador primario, como elemento básico para caracterizar elementos culturales presentes en el ambiente de cuidado al enfermo o discapacitado que está en casa a través de la indagación profunda de la percepción y sentimientos que tiene tanto el cuidador primario como el ser cuidado en casa. Se realizó con los usuarios inscritos del Programa de Promoción y Prevención de la indagación profunda de la percepción y sentimientos Universidad Popular del Cesar (IPS-UPC de los enfermos crónicos y discapacitados a nivel comunitario del grupo extramural de la comuna cinco y del Hospital Eduardo Arredondo Daza de la ciudad de Valledupar, Colombia. El valor de realizar este proyecto, está en desocultar los múltiples significados que en la realidad vivida por los seres cuidadores primarios y en los seres cuidados; son esas distintas formas de percibir la existencia, influido por el conocimiento de lo ancestral, los sentimientos y la sabiduría de la cultura que cada uno posee para expresarse en las múltiples formas que el cuidado lo acontece y lo requiere para dar el sentido cultural característico y diferenciado que se percibe en el modo de cuidar y la satisfacción de quien lo recibe y lo ofrece. Este aspecto fue valioso para la comunidad académica del programa de enfermería, porque ubicó epistémicamente la transculturalidad del cuidado como una mirada y forma de enseñar transdisciplinariamente, enseñando y ofreciendo el cuidado desde la cultura, sentimientos y pensamientos del ser cuidado para el mantenimiento de la vida y la salud, en la que estudiantes de enfermeria desde sus primeras experiencias formativas deben incursionar en la intervención holística que se requiere en el cuidado de la salud y de la vida.

  10. Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients.

    Science.gov (United States)

    Meng, Xiaodan; Joosse, Simon A; Müller, Volkmar; Trillsch, Fabian; Milde-Langosch, Karin; Mahner, Sven; Geffken, Maria; Pantel, Klaus; Schwarzenbach, Heidi

    2015-11-03

    Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC. Seven microRNAs (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429) were quantified in the serum of 180 EOC patients and 66 healthy women by TaqMan PCR microRNA assays. Median follow-up time was 21 months. The effects of miR-7 and miR-429 on apoptosis, cell proliferation, migration and invasion were investigated in two (EOC) cell lines. Serum levels of miR-25 (P=0.0001) and miR-93 (P=0.0001) were downregulated, whereas those of miR-7 (P=0.001) and miR-429 (P=0.0001) were upregulated in EOC patients compared with healthy women. The four microRNAs discriminated EOC patients from healthy women with a sensitivity of 93% and a specificity of 92%. The levels of miR-429 positively correlated with CA125 values (P=0.0001) and differed between FIGO I-II and III-IV stages (P=0.001). MiR-429 was an independent predictor of overall survival (P=0.011). Overexpressed miR-429 in SKOV3 cells led to suppression of cell migration (P=0.037) and invasion (P=0.011). Increased levels of miR-7 were associated with lymph node metastases (P=0.0001) and FIGO stages III-IV (P=0.0001). Overexpressed miR-7 in SKOV3 cells resulted in increased cell migration (P=0.001) and invasion (P=0.011). Additionally, the increased levels of miR-376a correlated with FIGO stages III-IV (P=0.02). Our data indicate the diagnostic potential of miR-7, miR-25, miR-93 and miR-429 in EOC and the prognostic potential of miR-429. This microRNA panel may be promising molecules to be targeted in the treatment of EOC.

  11. Tecnologias do lar e pedagogias de gênero: representações da “dona de casa ideal” na revista Casa & Jardim (anos 1950 e 1960)

    OpenAIRE

    Padilha, Ana Caroline de Bassi

    2014-01-01

    Neste trabalho, temos como objetivo investigar as associações entre tecnologias domésticas e tipos de feminilidades na revista Casa & Jardim como mídia de pedagogias de gênero. O recorte de estudo tem como foco os discursos textuais e imagéticos sobre tecnologias do lar veiculados na revista Casa & Jardim durante as décadas de 1950 e 1960. Neste período, as revistas direcionadas para públicos femininos buscavam criar uma identificação das mulheres com o espaço e o consumo domésticos, apresent...

  12. Métodos para determinar las casas del horóscopo en la astrología

    Directory of Open Access Journals (Sweden)

    Casulleras, Josep

    2009-06-01

    Full Text Available This paper revises the different methods of computation devised by Medieval Arabic astronomers and mathematicians for the astrological practice of the division of houses. Starting from a classification of these methods established by J.D. North (1986 and extended by E.S. Kennedy (1996, I summarize the available information contained in previous studies and present new data emerging from the analysis of more recently explored sources, emphasizing certain features of a Western astrological tradition.

    Este trabajo repasa los distintos métodos de cálculo que los astrónomos y matemáticos árabes medievales desarrollaron para ser aplicados a la práctica astrológica de la división de casas. Partiendo de una clasificación de estos métodos establecida por J.D. North (1986 y ampliada por E.S. Kennedy (1996, se recoge la información que se halla en estudios anteriores y se presentan nuevos datos como resultado del análisis de fuentes exploradas más recientemente, destacando ciertos elementos pertenecientes a una tradición astrológica occcidental.

  13. Validation of a novel computer-assisted sperm analysis (CASA) system using multitarget-tracking algorithms.

    Science.gov (United States)

    Tomlinson, Mathew James; Pooley, Karen; Simpson, Tracey; Newton, Thomas; Hopkisson, James; Jayaprakasan, Kannamanadias; Jayaprakasan, Rajisha; Naeem, Asad; Pridmore, Tony

    2010-04-01

    To determine the accuracy and precision of a novel computer-assisted sperm analysis (CASA) system by comparison with existing recommended manual methods. Prospective study using comparative measurements of sperm concentration and motility on latex beads and immotile and motile sperm. Tertiary referral fertility center with strong academic links. Sperm donors and male partners of couples attending for fertility investigations. None. Achievement of Accubead target value for high and low concentration suspensions. Repeatability as demonstrated by coefficients of variation and intraclass correlation coefficients. Correlation and limits of agreement between CASA and manual methods. The CASA measurements of latex beads and sperm concentrations demonstrated a high level of accuracy and repeatability. Repeated Accubead measurements attained the required target value (mean difference from target of 2.61% and 3.71% for high- and low-concentration suspensions, respectively) and were highly reproducible. Limits of agreement analysis suggested that manual and CASA counts compared directly could be deemed to be interchangeable. Manual and CASA motility measurements were highly correlated for grades a, b, and d but could not be deemed to be interchangeable, and manual motility estimates were consistently higher for motile sperm. The novel CASA system was able to provide semen quality measurements for sperm concentration and motility measurements which were at least as reliable as current manual methods. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  14. COSIMA-ES-PORT

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn; Leleur, Steen

    2007-01-01

    This article describes the results of the research project – WP3 East-west, Interreg IIIB – concerning the de¬velop¬ment of a new composite decision model, COSIMA-ES-PORT, for the assessment of three pre-feasibility studies situated at the Port of Esbjerg: a road project, a railway project...... and a multimodal terminal. The three studies indicates that a new road connection to the Port of Esbjerg is a very profitable project due to large travel time savings, whereas a new railway connection is not economically viable. However, a new multimodal terminal is also a very profitable project. The COSIMA...

  15. Reclaiming Sámi languages

    DEFF Research Database (Denmark)

    Rasmussen, Torkel; Nolan, John Shaun

    2011-01-01

    , this paper investigates what subsequently happens at the grassroots or micro level. This investigation shows that despite more positive policies, there is a strong sentiment of defeatism with regard to Sámi. Sámi speakers face problems because of the lack of implementation of nationally decided laws...... and for the sake of cultural maintenance, but also for instrumental reasons, i.e. to give their children better opportunities in the labor market where knowledge of Sámi is necessary....

  16. Teaching Cases in Management - Sabor de Casa Restaurant

    Directory of Open Access Journals (Sweden)

    Nilda Maria de Clodoaldo Pinto Guerra Leone

    2009-01-01

    Full Text Available Small family businesses present a series of peculiarities and challenges, especially when it comes to the management of human resources. This case describes the true situation of an enterprise, Restaurante Sabor de Casa, and portrays the relationship between the founder and successor and its consequences on the practice and policy of human resources. The story is told from the point of view of the successor, who thinks about the situation of the company and his deep involvement in the dynamic and complex stage of working with his mother, the founder of the company, whose performance is that of an entrepreneur, albeit a traditional one. It shows his reflections on the directions the company has taken, the opinions of employees, based on research conducted in 2006 by university students and their questions about the way the contributions of the employees are managed, mainly by recognizing their importance for both the present and the future of the company. This case deals with the complexity of the management of human resources in a family organizational environment.

  17. Gerrit Rietveld. Casas después de la Schroeder

    Directory of Open Access Journals (Sweden)

    Rafael García

    1997-07-01

    Full Text Available Las historias de la arquitectura moderna han incidido una y otra vez en un reducido número de obras que por su insistente atención, han llegado a convertirse en hitos imprescindibles. Entre estos edificios canónicos y prácticamente obligados, está la célebre casa Schröder-Schräder (1924' del arquitecto holandés Gerrit Rietveld. Ampliamente conocida por el público interesado, su gran popularidad ha tenido sin embargo, el efecto de dejar en segundo plano el resto de su obra arquitectónica. A ello se debe añadir además, el hecho de que su trayectoria está fundamentalmente asociada al movimiento neoplasticista, lo que ha tenido por resultado desviar la atención de una obra posterior, más difícilmente clasificable. Sin embargo, ello no significa que dicha obra sea en absoluto carente de atractivo.

  18. MiDAS

    DEFF Research Database (Denmark)

    McIlroy, Simon Jon; Kirkegaard, Rasmus Hansen; McIlroy, Bianca

    A deep understanding of the microbial communities and dynamics in wastewater treatment systems is a powerful tool for process optimization and design (Rittmann et al., 2006). With the advent of amplicon sequencing of the 16S rRNA gene, the diversity within the microbial communities can now...... web platform about the microbes in activated sludge and their associated ADs. The MiDAS taxonomy proposes putative names for each genus-level-taxon that can be used as a common vocabulary for all researchers in the field....

  19. A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature.

    Science.gov (United States)

    Seo, Min-Seob; Jang, Sumin; Kim, Hyunwoo

    2018-03-16

    A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (-40 to 10 °C) was required.

  20. El Futuro es Hoy

    Directory of Open Access Journals (Sweden)

    Alfonso Latiff Conde

    2002-08-01

    Full Text Available

    En ninguna otra época de la historia como en la nuestra se ha producido una transición tan rápida hacia el futuro, en el campo de la medicina.

    Lo que había sido una centuria de evolución desde la era Industrial a la era de la Informática, en la pasada década se ha convertido en una revolución.

    La cirugía laparoscopica que ha constituído el despertar a la edad de la informática como la tecnología lider es considerada ahora un standard en la práctica médica. En la actualidad tecnologias más avanzadas prometen mayores progresos en la medicina.

    La mayor revolución médica ocurrió en la cirugía en las postrimerias del siglo diecinueve cuando algunos gigantes de la medicina todavía caminaban sobre la tierra. Estos visionarios comprendieron la magnitud del cambio y dieron nacimiento a la nueva disciplina de la cirugía. Entre ellos estaban Bilroth, Lister, Virchow y Morton.

    Nunca trabajaron juntos, pero la integración espontánea de sus investigaciones y sus habilidades clínicas hicieron posible la nueva cirugía. Fue la convergencia de sus visiones y sus tecnologias las que dieron un vuelco a la cirugía. Bilroth aportó nuevas técnicas y nuevos instrumentos Lister aportó la asepsia, Virchow la patología y Morton la anestesia.

    Los antiguos mitos y muchos hechos empiricos hicieron creer por miles de años en la inviolabilidad del cuerpo humano. Las herramientas científicas de la Era Industrial convirtieron en realidad lo imposible y la ciencia dio nacimiento a la moderna cirugía. En un corto periodo de tiempo se establecieron los fundamentos de una cirugía que permitiría a las siguientes generaciones liderar nuevos avances y tecnologias.

    Nada estremeció más los fundamentos de la medicina como esta explosión de la cirugía. Comprender el shock, la cirugía cardiaca y coronaria, los trasplantes, tuvieron un enorme impacto que conmocionó la medicina. Es obvio que los cambios producidos

  1. EL CIRCO Y MI DILEMA

    Directory of Open Access Journals (Sweden)

    Martalucía Tamayo

    2015-03-01

    habilidades excepcionales, temo que lo que se esté buscando (¿o logrando? es un aplauso lleno de compasión o lástima por su condición de “seres diferentes”; o más bien agradados por haber presenciado “un fenómeno” digno de ser exhibido para la curiosidad morbosa de la gente. Ojalá no haya sido por eso. Tengo el mismo sentimiento de rechazo a los movimientos tipo “Teletón”, que suelen recoger ayuda económica mediante la explotación de un sentimiento de “compasión y lástima”. He luchado toda mi vida para que la sociedad no olvide el valor de la diferencia, el respeto a ella, el derecho a ser y vivir diferente; y hemos trabajado por muchos años para que esas personas “diferentes” sean (seamos “sujetos de derechos” igual que cualquier otro ser humano. Lo triste, y he ahí mi dilema, es que muchas personas del público comentan “pobrecitos, tan tiernos, al menos estos dos tienen empleo y viven de algo” y me digo que es verdad; son de los pocos que quizás logren sobrevivir económicamente bien en un mundo que está lejos de ser fácil para ellos. Pero ahí surge el dilema y el temor de que la sociedad aprenda a ver las cosas de manera equivocada. Y... ¿la dignidad? ¿Dónde queda la concientización o sensibilización de la sociedad? ¿Dónde queda el respeto a la diferencia? ¿A quién podría gustarle ser exhibido como fenómeno? ¿Alguien se ha preguntado el drama que vive el “ser diferente” en un mundo que no está diseñado para todo el mundo?...

  2. ANÁLISE HISTÓRICA DAS TRANSFORMAÇÕES DA FLORESTA AMAZÔNICA EM ÁREAS AGRÍCOLAS NA BACIA DO RIO SUIA-MIÇU. - Historical Changes of the Amazonian Forest into Agricultural Lands in the Suia-Miçu River Basin.

    Directory of Open Access Journals (Sweden)

    Antonio Roberto Formaggio

    2008-06-01

    Full Text Available Mudanças no uso e cobertura da terra, como as ocorridas nas áreas de expansão agrícola na AmazôniaLegal, geram uma série de impactos sociais, econômicos e ambientais. O entendimento destes processospode permitir um melhor planejamento de políticas públicas a fim de monitorar e mapear áreas maissuscetíveis a problemas ambientais. Sendo assim, este trabalho teve como objetivo analisar a dinâmicade ocupação da Bacia do Rio Suiá-Miçu, um dos afluentes do Rio Xingu localizado ao norte do estadodo Mato Grosso. Os mapas de uso e cobertura da terra para cada um dos períodos analisados (1973,1984 e 2005 foram confeccionados com o auxílio de imagens dos sensores MSS/Landsat-1, TM/Landsat-5 e do sensor MODIS/Terra. Os resultados mostraram que até 1984, 13% da vegetação natural dabacia havia sido desflorestada, enquanto que em 2005 as atividades agrícolas já ocupavam 40% daárea de estudo. Desta forma, tendo em vista as mudanças na paisagem observadas ao longo das últimasdécadas, torna-se notória a necessidade urgente de estudos mais aprofundados visando a avaliaçãodos impactos ambientais, bem como a preservação dos recursos naturais na regiãoLand use and land cover changes, as seen in the agricultural expansion areas in the Brazilian LegalAmazon, have as consequence several social, economic and environmental impacts. The understandingof these processes allows a better planning of public policies in order to monitor and map areas moresusceptible to environmental problems. Hence, this work had as objective to analyze the land use/landcover changes dynamics in the Suiá-Miçu River Basin, located in the north part of Mato Grosso state,Brazil. The land use/land cover maps for each of the analyzed periods (1973, 1984 and 2005 weremade using images from the MSS/Landsat-1, TM/Landsat-5 and the MODIS/Terra sensors. The resultsshowed that until 1984, 13% of the natural vegetation of the watershed was deforested, while in 2005the

  3. Description and evaluation of the CASA dual-Doppler system

    Science.gov (United States)

    Martinez, Matthew

    2011-12-01

    Long range weather surveillance radars are designed for observing weather events for hundreds of kilometers from the radar and operate over a large coverage domain independently of weather conditions. As a result a loss in spatial resolution and limited temporal sampling of the weather phenomenon occurs. Due to the curvature of the Earth, long-range weather radars tend to make the majority of their precipitation and wind observations in the middle to upper troposphere, resulting in missed features associates with severe weather occurring in the lowest three kilometers of the troposphere. The spacing of long-range weather radars in the United States limits the feasibility of using dual-Doppler wind retrievals that would provide valuable information on the kinematics of weather events to end-users and researchers. The National Science Foundation Center for Collaborative Adapting Sensing of the Atmosphere (CASA) aims to change the current weather sensing model by increasing coverage of the lowest three kilometers of the troposphere by using densely spaced networked short-range weather radars. CASA has deployed a network of these radars in south-western Oklahoma, known as Integrated Project 1 (IP1). The individual radars are adaptively steered by an automated system known as the Meteorological Command and Control (MCC). The geometry of the IP1 network is such that the coverage domains of the individual radars are overlapping. A dual-Doppler system has been developed for the IP1 network which takes advantage of the overlapping coverage domains. The system is comprised of two subsystems, scan optimization and wind field retrieval. The scan strategy subsystem uses the DCAS model and the number of dual-Doppler pairs in the IP1 network to minimizes the normalized standard deviation in the wind field retrieval. The scan strategy subsystem also minimizes the synchronization error between two radars. The retrieval itself is comprised of two steps, data resampling and the

  4. Rehabilitación casa Arruebo en Escarrilla (Huesca)

    OpenAIRE

    Arruebo Pérez, Eduardo

    2015-01-01

    El objetivo de este trabajo es la rehabilitación de la vivienda situada el la calle de la iglesia numero 2 de Escarrilla (Huesca) propiedad de mis padres, adaptándola a las nuevas necesidades familiares y mejorar su eficiencia energética. La vivienda esta ubicada en una parcela de 973 m² y 337,64 m² habitables distribuidos en tres plantas, sin contar la buhardilla. La construcción es del año 1961 y no se ha realizado ninguna obra de importancia desde la fecha y con un mantenimi...

  5. El "peixet": La experiencia de parir en casa The "peixet": The experience of giving birth at home

    Directory of Open Access Journals (Sweden)

    Ana Belén Rodríguez Feijóo

    2009-03-01

    Full Text Available El relato biográfico que nos ocupa, se basa en la experiencia vivida por una pareja (Elia y Daniel que quería vivir el parto de su primera hija (Illary de la forma más natural posible, por eso decidieron que naciera en casa. Su acceso a instituciones o profesionales (matronas que los ayudaran a realizar su deseo, fue relativamente fácil, al vivir en una comunidad autónoma (Cataluña en la que la oferta con respecto al parto en casa es superior a otras comunidades, dentro de la escasez existente en tal ámbito. Tras informarse del proceso y de la oferta existente, se decidieron por una asociación especializada, de la que formaba parte la matrona que finalmente los atendió (se omiten nombres reales. El título dado a esta historia, el peixet (traducido al castellano significa el pececillo, se debe a ser este el apodo cariñoso dado por estos padres a su hija, al producirse el nacimiento en el agua. Su valoración final del parto es positiva, deseando repetirla, a pesar del coste económico y de la falta de apoyo y comprensión social.Interview that occupies to us, bases on experience lived by pair (Elia and Daniel who wanted to live the childbirth of their first daughter (Illary of the possible most natural form, for that reason decided that it was born at home. Their access to institutions or professionals (midwives who helped them to make their desire, it was relatively easy to live in an autonomous community (Cataluña in which the supply with respect to the childbirth at home is superior to other communities within the existing shortage in such scope. After inquiring into the process and the existing supply, they were decided by a specialized association, which was part or the midwife comprised that finally took care of them (real name are omitted. The title given to this history, peixet (translated the Castilian it means the small fish, is due to this being the affectionate nickname given by these parents to their daughter, when taking

  6. El gobierno de la casa en Atenas clásica: género y poder en el "oikos"

    Directory of Open Access Journals (Sweden)

    María Dolores MIRÓN PÉREZ

    2010-02-01

    Full Text Available RESUMEN: La sociedad ateniense de los siglos V y IV a.C. es una de las que con mayor nitidez presenta diferenciación de papeles y espacios según el género: exterior/£> o/¿s/varón e interior/oz&os/mujer. Frente al poder público de los varones, la dirección de los asuntos internos del hogar es entendida como esfera de autoridad naturalmente femenina. No obstante esta división de competencias, ellas también conocen los asuntos externos de la casa, ya que el gobierno de ésta en todos sus ámbitos tiende a ejercerse conjuntamente por el marido y la esposa, siendo las funciones de ambos interdependientes e igualmente importantes. Esta autoridad femenina estará limitada por la decisión última del cabeza de familia, un varón, punto de intersección entre lo público y lo privado, y con capacidad legal en ambos ámbitos. La autoridad suprema en la casa corresponde al esposo, quien delega en su esposa las competencias para las que, por su naturaleza, se considera más apta una mujer. Sin embargo, ante la ausencia del marido, la esposa puede temporalmente erigirse de facto —aunque nunca legalmente— en auténtica cabeza de familia y en garante de la supervivencia del oikos.ABSTRACT: Athenian society of 5th and 4th centuries B. C. especially displays a clear gender differentiation of roles and spaces: exterior/^o/zVmen and interior/oz'&os/women. If men control public power, women exercise authority over the inner spheres of the household. Despite their different domains, women also have knowledge about external spheres, as both husband and wife jointly rule the household. Both domains were interdependent and equally important, but woman's authority was limited by the ultimate decision of the male head of household. He was the intermediary between the public and private worlds and he had legal capacity in both spheres. He is the supreme authority in the household and delegates to her wife the fields «naturally» more appropriate to women

  7. Casa de un arquitecto, Hörtekaer (Dinamarca

    Directory of Open Access Journals (Sweden)

    Jorgen Bo

    1960-07-01

    Full Text Available De una forma sencilla, pero admirablemente resuelta, ha sido diseñada esta vivienda, de dimensiones medias, compuesta de: tres dormitorios, estar, comedor, cocina, cuarto de baño, aseo, estudio en primera planta, desván y sótano. Es la morada del propio arquitecto.

  8. Capilla de la casa de ejercicios de las Hijas de la Caridad de San Vicente de Paúl Barcelona - España

    Directory of Open Access Journals (Sweden)

    Mir Valls, Jorge

    1975-04-01

    Full Text Available Special mention is made in this article of the chapel with oval plan form. It is situated in the bisection of the L-shaped, symmetrically winged body which is the Prayer House. The chapel consists of: basement, with auditorium, ground floor with the actual chapel, vestry and hall; the first floor of the Prayer House communicates directly with the choir. The basic materials are: unfaced concrete, artificial stone and wooden roof, with parabolic tie rods or catenaries, planking, and isolating and waterproofing layers.La capilla, de planta ovalada, es la que se describe especialmente en este artículo. Se halla en la bisectriz del cuerpo en L, de alas simétricas, constituido por la Casa de Ejercicios. Consta de: SEMISOTANO, con salón de actos, y BAJA, con la capilla —propiamente dicha—, sacristía y vestíbulo; desde la PLANTA PRIMERA de la Casa de Ejercicios se accede al coro. Los materiales fundamentales son: hormigón visto, piedra artificial y cubierta de madera, con tirantes o catenarias parabólicas, entablonado y capas aislante e impermeabilizante.

  9. Cajas vacías para la emoción. Los patios interiorizados de la Casa Carvajal en Somosaguas, Madrid

    Directory of Open Access Journals (Sweden)

    Sonia Vázquez-Díaz

    2017-11-01

    Full Text Available La Casa Carvajal es el resultado de una profunda reflexión sobre el papel del patio en la arquitectura moderna; un arquetipo inicialmente repudiado al juzgarse asociado a una espacialidad tradicional, introvertida y deudora de una concepción escindida entre interior y exterior. Sin embargo, tras este primer rechazo, el patio se incorpora de forma paulatina a la modernidad y, gracias precisamente a la integración de la concavidad que proporciona, permite que evolucionen y se complejicen los conceptos espaciales de la misma, tanto en relación a la apertura y fenomenización del espacio, como a la transparencia fenomenológica. Este artículo se propone mostrar cómo estos conceptos se manifiestan en los patios interiorizados de la Casa Carvajal, revelando, gracias a ello, la función determinante de los patios en la culminación de la modernidad. Mediante el análisis del orden formal y de las percepciones, a lo largo de la secuencia espacial que va desde el acceso hasta el entorno de los patios, se pondrá además de manifiesto que estos vacíos constituyen elementos esenciales en la estrategia de proyecto, tanto en el plano morfo-sintáctico, al constituir el germen de la lógica formal, como en el plano perceptivo-emocional, al cualificar el espacio como marco del habitar.

  10. Que es lo que queda cuando el agua se va

    Directory of Open Access Journals (Sweden)

    Hernán Ascui Fernández

    2007-10-01

    Full Text Available El agua siempre deja huellas de su paso. Las aguas del Nilo, después de inundar las llanuras del río, se retiraban dejando el suelo colmado de los nutrientes que habían traído desde el corazón de África. Las costas de Chile han sido modeladas por el ir y venir de las aguas marinas, el río Ibáñez ha esculpido un profundo canal en la roca para abrirse paso, dando nacimiento a un magnífico lugar conocido como Garganta del río Ibáñez. Las cascadas horadan montañas para poder deslizarse como blancas lágrimas, la sobrecogedora belleza de los glaciares ha dejado potentes huellas de sus trayectorias. La lluvia también deposita marcas en los lugares y superficies que moja. A veces son apenas sutiles señales como el musgo que crece en las piedras húmedas o en el perfume de los bosques de Valdivia, con su tierra negra y empapada de lluvia y rocío. Otras veces las huellas del agua están presentes en la arquitectura como ocurre con los palafitos de Castro o Caleta Tortel, donde las casas se levantan para tomar distancia del agua que se mueve al ritmo de las mareas. En otras ocasiones, las huellas del descorren el velo de un drama urbano; es lo que ocurrió con la inundación del invierno pasado. Las huellas del agua aún son visibles en las paredes manchadas, en los muebles, en los pisos. El agua se fue pero dejando tras de sí un desalentador recuerdo de su paso por las ciudades, los pueblos y las casas.

  11. Mulheres cuidando de mulheres: um estudo sobre a Casa de Apoio Viva Maria, Porto Alegre, Rio Grande do Sul, Brasil Women caring for women: a study on the "Viva Maria" shelter, Porto Alegre, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    2000-09-01

    Full Text Available Este trabalho teve como objetivo obter dados a respeito de mulheres vitimizadas que são atendidas em uma casa abrigo governamental denominada "Casa de Apoio Viva Maria", situada na cidade de Porto Alegre. Analisaram-se informações referentes a 110 mulheres que estiveram albergadas na casa durante os últimos dois anos - janeiro de 1996 a junho de 1998. O perfil da clientela mostrou que as mulheres eram jovens - em média, 29 anos; todas de baixa renda; 12% analfabetas, 21% negras, 80% delas com história de violência doméstica freqüente. Além disso, 18% destas mulheres retornaram à relação com o companheiro violento. Foram efetuadas visitas domiciliares a 34 ex-moradoras, convidando-as a participar de uma série de oficinas de avaliação. Um total de 118 pessoas - mães e crianças - integrou os três encontros de avaliação. Durante estes, os pesquisadores estimularam as participantes a expressar suas opiniões, percepções e sentimentos a respeito da experiência vivida na casa abrigo, assim como seus conceitos no tocante à violência. Finalmente, realizou-se um grupo focal com a equipe técnico-administrativa da casa. As trabalhadoras enfatizaram o quanto esse tipo de trabalho tem sido útil para seu desenvolvimento pessoal e auxiliou a modificar suas vidas.This research was conducted in Porto Alegre, Rio Grande do Sul, with a sample of battered women selected from a government shelter called the "Casa Viva Maria". We analyzed data on 110 women staying at the shelter during the previous two years (January 1996-June 1998. The profile of the women was as follows: abused women were young (mean age 29 years, all had low socioeconomic status, 12% were illiterate, 21% were black, 80% reported frequent abuse by their partners, and 18% had returned to violent homes. The researchers visited 34 former lodgers from the shelter and invited them to participate in a series of evaluation workshops. A total of 118 persons, including mothers and

  12. A casa assombrada: considerações sobre o especular e o escópico

    Directory of Open Access Journals (Sweden)

    Andrea Menezes Masagão

    2010-03-01

    Full Text Available A casa é um espaço privilegiado para abordar a identidade, visto que remete à origem e ao reconhecimento. No entanto, nem sempre o ser está em uma relação de adequação a seu habitat. Edgar Allan Poe trabalha o jogo dialético entre o familiar e o estranho de uma forma magistral em seu conto “A queda da casa de Usher”. A dialética do espaço da casa permite abordar o lugar especular do eu, bem como o lugar de ausência do sujeito para além da imagem do espelho. É na queda do suporte especular que surge a dimensão assustadora do olhar.

  13. A comparison of several computational auditory scene analysis (CASA) techniques for monaural speech segregation.

    Science.gov (United States)

    Zeremdini, Jihen; Ben Messaoud, Mohamed Anouar; Bouzid, Aicha

    2015-09-01

    Humans have the ability to easily separate a composed speech and to form perceptual representations of the constituent sources in an acoustic mixture thanks to their ears. Until recently, researchers attempt to build computer models of high-level functions of the auditory system. The problem of the composed speech segregation is still a very challenging problem for these researchers. In our case, we are interested in approaches that are addressed to the monaural speech segregation. For this purpose, we study in this paper the computational auditory scene analysis (CASA) to segregate speech from monaural mixtures. CASA is the reproduction of the source organization achieved by listeners. It is based on two main stages: segmentation and grouping. In this work, we have presented, and compared several studies that have used CASA for speech separation and recognition.

  14. La así llamada casa de Hippolytus: la fundación de los Anios y la schola de una agrupación colegial de la ciudad romana de Complutum

    Directory of Open Access Journals (Sweden)

    Rascón Marqués, Sebastián

    2007-12-01

    Full Text Available This paper is a review of existent data about Complutum so-called Casa de Hippolytus (Alcalá de Henares – Madrid. A multiple range of documents, belonging to different methods (methodical excavation, archaeobotanic, archaeozoology, historiography, probes that it was a collegia see, bound in the same enclosure with an Oriental garden and with Annios family Mausoleum, the same people who built the collegium schola. At the same time, this paper refute one recent proposal for the site, and refuse the explanation of Casa de Hippolytus as a suburban balneum belonging to a domus.El objetivo de este artículo es actualizar los datos existentes sobre la llamada Casa de Hippolytus de Complutum / Alcalá de Henares. El análisis de la documentación aportada por varios métodos (excavación sistemática, estudios arqueobotánicos, zoológicos, historiográficos, etc. demuestra que se trata de la sede de una agrupación colegial, que se vincula, en un mismo recinto, con un jardín orientalizante y con el mausoleo de la familia de los Anios, la misma que construye la schola de la asociación colegial. Al mismo tiempo refutamos otra interpretación propuesta para este yacimiento, y desechamos que se trate del balneum de una domus suburbana.

  15. Different computer-assisted sperm analysis (CASA) systems highly influence sperm motility parameters.

    Science.gov (United States)

    Boryshpolets, S; Kowalski, R K; Dietrich, G J; Dzyuba, B; Ciereszko, A

    2013-10-15

    In this study, we examined different computer-assisted sperm analysis (CASA) systems (CRISMAS, Hobson Sperm Tracker, and Image J CASA) on the exact same video recordings to evaluate the differences in sperm motility parameters related to the specific CASA used. To cover a wide range of sperm motility parameters, we chose 12-second video recordings at 25 and 50 Hz frame rates after sperm motility activation using three taxonomically distinct fish species (sterlet: Acipenser ruthenus L.; common carp: Cyprinus carpio L.; and rainbow trout: Oncorhynchus mykiss Walbaum) that are characterized by essential differences in sperm behavior during motility. Systematically higher values of velocity and beat cross frequency (BCF) were observed in video recordings obtained at 50 Hz frame frequency compared with 25 Hz for all three systems. Motility parameters were affected by the CASA and species used for analyses. Image J and CRISMAS calculated higher curvilinear velocity (VCL) values for rainbow trout and common carp at 25 Hz frequency compared with the Hobson Sperm Tracker, whereas at 50 Hz, a significant difference was observed only for rainbow trout sperm recordings. No significant difference was observed between the CASA systems for sterlet sperm motility at 25 and 50 Hz. Additional analysis of 1-second segments taken at three time points (1, 6, and 12 seconds of the recording) revealed a dramatic decrease in common carp and rainbow trout sperm speed. The motility parameters of sterlet spermatozoa did not change significantly during the 12-second motility period and should be considered as a suitable model for longer motility analyses. Our results indicated that the CASA used can affect motility results even when the same motility recordings are used. These results could be critically altered by the recording quality, time of analysis, and frame rate of camera, and could result in erroneous conclusions. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Exposição ocupacional por material biológico no Hospital Santa Casa de Pelotas - 2004 a 2008 La exposición ocupacional a material biológico en el Hospital Santa Casa de Pelotas - 2004 a 2008 Occupational exposure to biological material at the Hospital Santa Casa de Pelotas - 2004 to 2008

    Directory of Open Access Journals (Sweden)

    Lílian Moura de Lima

    2011-03-01

    Full Text Available A pesquisa trata de exposições ocupacionais por material biológico a que foram submetidos os profissionais de saúde, no Hospital Santa Casa de Misericórdia de Pelotas, no período de janeiro de 2004 a junho de 2008. Trata-se de um estudo transversal, descritivo, com abordagem quantitativa. Utilizou-se como instrumento de pesquisa um questionário elaborado com base na ficha de notificação de acidente de trabalho da referida instituição. Os dados foram digitados e analisados no programa Epi-info 6.04. Como principal resultado encontrou-se a maior ocorrência de acidentes de trabalho com material biológico entre os profissionais técnicos em enfermagem do sexo feminino (38,6%, com idade de 21 a 30 anos (53,9%. A maioria dos acidentes aconteceu através de lesões com perfurocortantes (82,2%, sendo 24,1% no Centro Cirúrgico e 84,5% envolvendo sangue. Conclui-se que o estudo é de extrema relevância, pois, com base no reconhecimento do tipo de acidentes mais frequentes, pode-se conhecer os riscos existentes e intervir na sua redução, por meio de ações preventivas que beneficiem o trabalhador e a instituição.El estudio aborda la exposición ocupacional a material biológico a que fueron sometidos los profesionales de salud en el Hospital Santa Casa de Misericordia de Pelotas, de enero de 2004 a junio de 2008. Este es un corte transversal, descriptivo y cuantitativo. Se utiliza como herramienta de investigación un cuestionario basado en el formulario de informe de accidente de trabajo de esa institución. Los datos fueron introducidos y analizados con Epi-Info 6.04. Como principal resultado se encontró una mayor incidencia de accidentes con material biológico entre los profesionales técnicos de enfermería del sexo femenino (38,6%, de 21 años a 30 años (53,9%. La mayoría de los accidentes ocurrió a través de lesiones con objetos punzantes (82,2%, siendo que 24,1% ocurrió en el Centro Quirúrgico, y 84,5% con sangre. Se

  17. A Casa do Fim: um conto de José Riço Direitinho

    OpenAIRE

    Oliveira, Catarina Alexandra Monteiro de

    2003-01-01

    The book A Casa do Fim by young writer José Riço Direitinho is made up of ten short and independent stories, stories of life and, above all, of death, played by unusual characters. The writer shapes a strongly rural fictional universe, where he mingles what is real and what is fantastic. A Casa do Fim is a structurally and semantically fractured story, where deep wisdom and ancestral habits are passed on from mother to daughter. The son atones for the sins of the father, and suicide is sho...

  18. Expression profiling of miR-96, miR-584 and miR-422a in colon ...

    African Journals Online (AJOL)

    Purpose: To determine the correlation between miRNAs; miR-96, miR-422a and miR584, and colon cancer, and also to test whether any of these miRNAs can act as non-invasive biomarkers in colon cancer. Methods: The tumor samples and the corresponding normal mucosa used in this study were collected from 60 ...

  19. Violencia, anticoncepción y embarazo no deseado. Mujeres indígenas en San Cristóbal de Las Casas, Chiapas

    Directory of Open Access Journals (Sweden)

    M. Georgina Rivas

    2009-01-01

    Full Text Available Este estudio es parte de una investigación cualitativa que se realizó en San Cristóbal de Las Casas, Chiapas, México. Con base en entrevistas a mujeres indígenas inmigrantes, se hacen evidentes la influencia del entorno de marginación social así como el abuso de poder de los varones en el origen del embarazo no deseado. La sobrevaloración de los saberes masculinos, la expectativa de formar una unión como mandato social y como estrategia de sobrevivencia, así como la violencia que sufren las mujeres a lo largo de su ciclo de vida, condicionan su aceptación de relaciones sexuales con escasa protección anticonceptiva.

  20. Generation of miRNA sponge constructs

    NARCIS (Netherlands)

    Kluiver, Joost; Slezak-Prochazka, Izabella; Smigielska-Czepiel, Katarzyna; Halsema, Nancy; Kroesen, Bart-Jan; van den Berg, Anke

    2012-01-01

    MicroRNA (miRNA) sponges are RNA molecules with repeated miRNA antisense sequences that can sequester miRNAs from their endogenous targets and thus serve as a decoy. Stably expressed miRNA sponges are especially valuable for long-term loss-of-function studies and can be used in vitro and in vivo. We

  1. El juego de la casa de cambio como una estrategia didáctica en la construcción de un sistema de numeración posicional. Proyecto juega y construye la matemática

    OpenAIRE

    Arredondo, John Faber; Quiseno, Maryuri Zulay

    2010-01-01

    El juego "La casa de cambio" es una propuesta pedagógica que busca desarrollar en los estudiantes un alto nivel de comprensión del sistema decimal, sus propiedades y cómo se conforma, abordando primero diferentes procesos operacionales en base 2 (sistema binario) o en otras bases, similares a los procesos que se realizan en el sistema decimal, tomándolo como un "juego de cambio" y en donde a raíz del trabajo continuo y articulado, los estudiantes construyen o deducen las propiedades que lo re...

  2. Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

    Directory of Open Access Journals (Sweden)

    Qiu Shuwei

    2013-01-01

    Full Text Available Abstract Background Glioblastoma multiforme (GBM is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs is involved in GBM. Therefore, we attempted to identify and develop specific miRNAs as prognostic and predictive markers for GBM patient survival. Methods Expression profiles of miRNAs and genes and the corresponding clinical information of 480 GBM samples from The Cancer Genome Atlas (TCGA dataset were downloaded and interested miRNAs were identified. Patients’ overall survival (OS and progression-free survival (PFS associated with interested miRNAs and miRNA-interactions were performed by Kaplan-Meier survival analysis. The impacts of miRNA expressions and miRNA-interactions on survival were evaluated by Cox proportional hazard regression model. Biological processes and network of putative and validated targets of miRNAs were analyzed by bioinformatics. Results In this study, 6 interested miRNAs were identified. Survival analysis showed that high levels of miR-326/miR-130a and low levels of miR-323/miR-329/miR-155/miR-210 were significantly associated with long OS of GBM patients, and also showed that high miR-326/miR-130a and low miR-155/miR-210 were related with extended PFS. Moreover, miRNA-323 and miRNA-329 were found to be increased in patients with no-recurrence or long time to progression (TTP. More notably, our analysis revealed miRNA-interactions were more specific and accurate to discriminate and predict OS and PFS. This interaction stratified OS and PFS related with different miRNA levels more detailed, and could obtain longer span of mean survival in comparison to that of one single miRNA. Moreover, miR-326, miR-130a, miR-155, miR-210 and 4 miRNA-interactions were confirmed for the first time as independent predictors for survival by Cox regression model

  3. Mi palabra favorita. Una actividad con vídeo

    Directory of Open Access Journals (Sweden)

    Susana Cañuelo Carrión

    2011-01-01

    Full Text Available Mi palabra favorita es un actividad que surge a partir de la propuesta que realiza el Instituto Cervantes con la web El día E (www.eldiae.es. Este portal fue creado en conmemoración del día del español, que se celebra desde 2009 el último sábado de junio. Para festejar la vitalidad de la lengua y el interés mundial que despierta, hablantes y aprendientes de todo el mundo pueden explicar en dicho portal cuál es su palabra favorita. Y pueden hacerlo con un texto, con un pictograma o con un vídeo.

  4. Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

    International Nuclear Information System (INIS)

    Schee, Kristina; Boye, Kjetil; Abrahamsen, Torveig Weum; Fodstad, Øystein; Flatmark, Kjersti

    2012-01-01

    MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and associations with clinicopathological parameters and patient outcome were analyzed. The miRNAs were chosen based on previous studies for their biomarker potential and suggested biological relevance in colorectal cancer. The miRNA expression was examined by qRT-PCR. Associations between miRNA expression and clinicopathological variables were explored using Mann–Whitney U and Kruskal-Wallis test while survival was estimated using the Kaplan-Meier method and compared using the log-rank test. MiR-101 was hardly expressed in the tumor samples, while for the other miRNAs, variable expression levels and expression ranges were observed, with miR-21 being most abundantly expressed relative to the reference (RNU44). In our study cohort, major clinical significance was demonstrated only for miR-31, as high expression was associated with advanced tumor stage and poor differentiation. No significant associations were found between expression of the investigated miRNAs and metastasis-free or overall survival. Investigating the expression of six miRNAs previously identified as candidate biomarkers in colorectal cancer, few clinically relevant associations were detected in our patient cohort. Our results emphasize the importance of validating potential tumor markers in independent patient cohorts, and indicate that the role of miRNAs as colorectal cancer biomarkers is still undetermined

  5. LA CASA CON PATIO EN MIES VAN DER ROHE / House with patio from Mies van der Rohe

    Directory of Open Access Journals (Sweden)

    José Altés Bustelo

    2013-05-01

    Full Text Available RESUMEN Una revisión del tema Casa con Patio, con especial atención a los planteamientos desarrollados por Mies van der Rohe durante sus últimos años en Berlín, a propósito del conocido dibujo denominado “Casa con tres patios”. Se explora su pensamiento arquitectónico a partir de los datos historiográficos de su trayectoria, más los que se pueden deducir del análisis de los dibujos y croquis previos del arquitecto. El conjunto de proyectos en que aparece el tema es muy amplio durante ese tiempo y los dibujos conservados ofrecen múltiples reflexiones. Sobre ese soporte se examinan conceptos relativos a la definición espacial y formal, donde aparecen cuestiones que ligan esa definición con los sistemas y materiales constructivos. Malla estructural, muro, pared de vidrio y patio vividero, vinculados necesariamente a sus respectivas cualidades tectónicas, adquieren el sentido de materiales de proyecto utilizados para definir un particular modo de entender la arquitectura en el que el usuario está presente siempre como destinatario de la misma. Finalmente, se plantea la utilidad didáctica del análisis de esos dibujos para el progreso del conocimiento en el proyecto arquitectónico.SUMMARY A review of the theme, House with Patio, with special reference to the plans developed by Mies van der Rohe during his last years in Berlin, in relation to the well–known drawing called: “House with three patios”. His architectural thoughts are explored through the historiographic data of his career, plus those that can be deduced from the analysis of the architect’s previous drawings and sketches. The group of projects, in which the theme appears is prolific from that time, and the preserved drawings offer multiple opportunities for reflection. Concepts on that medium are examined, relative to spatial and formal definition, where questions appear that link that definition with the constructive systems and materials. Structural mesh

  6. miREE: miRNA recognition elements ensemble

    Science.gov (United States)

    2011-01-01

    Background Computational methods for microRNA target prediction are a fundamental step to understand the miRNA role in gene regulation, a key process in molecular biology. In this paper we present miREE, a novel microRNA target prediction tool. miREE is an ensemble of two parts entailing complementary but integrated roles in the prediction. The Ab-Initio module leverages upon a genetic algorithmic approach to generate a set of candidate sites on the basis of their microRNA-mRNA duplex stability properties. Then, a Support Vector Machine (SVM) learning module evaluates the impact of microRNA recognition elements on the target gene. As a result the prediction takes into account information regarding both miRNA-target structural stability and accessibility. Results The proposed method significantly improves the state-of-the-art prediction tools in terms of accuracy with a better balance between specificity and sensitivity, as demonstrated by the experiments conducted on several large datasets across different species. miREE achieves this result by tackling two of the main challenges of current prediction tools: (1) The reduced number of false positives for the Ab-Initio part thanks to the integration of a machine learning module (2) the specificity of the machine learning part, obtained through an innovative technique for rich and representative negative records generation. The validation was conducted on experimental datasets where the miRNA:mRNA interactions had been obtained through (1) direct validation where even the binding site is provided, or through (2) indirect validation, based on gene expression variations obtained from high-throughput experiments where the specific interaction is not validated in detail and consequently the specific binding site is not provided. Conclusions The coupling of two parts: a sensitive Ab-Initio module and a selective machine learning part capable of recognizing the false positives, leads to an improved balance between

  7. CASAS Competencies: Essential Life and Work Skills for Youth and Adults

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2008

    2008-01-01

    The CASAS Competencies identify more than 360 essential life skills that youth and adults need to be functionally competent members of their community, their family, and the workforce. Competencies are relevant across the full range of instructional levels, from beginning literacy through high school completion including transition to…

  8. Guidelines for Providing Accommodations Using CASAS Assessment for Learners with Disabilities

    Science.gov (United States)

    CASAS - Comprehensive Adult Student Assessment Systems (NJ1), 2005

    2005-01-01

    These guidelines address methods for administering Comprehensive Adult Student Assessment System (CASAS) assessments using accommodations for learners with documented disabilities. The suggested accommodations for disability categories include provisions for: (1) Accommodations in test administration procedures; and (2) Use of appropriate CASAS…

  9. [History of the locations of the Casa de Orates (madhouse) in Santiago, Chile].

    Science.gov (United States)

    Osorio A, Carlos G

    2016-03-01

    This work describes the origin of the different locations that Casa de Orates (Madhouse) has occupied in Chile. The locations of this institution at the Yungay and Chimba neighborhoods area are specially analyzed. Moreover, the sad and poorly known incident involving the national Madhouse of Providencia is narrated.

  10. Differences in CASA output according to the chamber type when analyzing frozen-thawed bull sperm.

    Science.gov (United States)

    Ibănescu, Iulian; Leiding, Claus; Ciornei, Ştefan Gregore; Roșca, Petru; Sfartz, Ioana; Drugociu, Dan

    2016-03-01

    As demonstrated by some authors, the type of analyzing chamber can greatly influence the results of computer-assisted sperm analysis (CASA). This study aimed to compare three of the disposable chamber types currently available on the market and to determine whether the CASA output may be significantly different among them. The semen from five Fleckvieh bulls was analyzed by CASA using three different disposable chambers: Leja (20μm), MofA (20μm) and Minitube (20μm), at three different time points: immediately after filling the chamber, at 6min, and also at 12min after filling. Sperm concentration was also determined using the Nucleocounter® NC-100™ device and the hemocytometer as standard methods. The results showed higher values in terms of total and progressive sperm motility for MofA compared to the other two chambers immediately after filling (pCASA only when the other methods are not available. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Peer Assessment and Compliance Review (PACR) Innovative Strategies Report. California Court Appointed Special Advocates (CASA) Programs

    Science.gov (United States)

    Macro, Bronwen; Huang, Lee Ann

    2005-01-01

    This report focuses on the innovative strategies study component of the Peer Assessment and Compliance Review (PACR) project. California (Court Appointed Special Advocates) CASA programs have developed many innovative strategies to serve children in their communities. At each of the programs visited during the PACR project, the team identified at…

  12. MONTHLY VARIATION IN SPERM MOTILITY IN COMMON CARP ASSESSED USING COMPUTER-ASSISTED SPERM ANALYSIS (CASA)

    Science.gov (United States)

    Sperm motility variables from the milt of the common carp Cyprinus carpio were assessed using a computer-assisted sperm analysis (CASA) system across several months (March-August 1992) known to encompass the natural spawning period. Two-year-old pond-raised males obtained each mo...

  13. The Cinematic Genesis of the Mel Casas Humanscape, 1965-1967

    Science.gov (United States)

    Cordova, Ruben C.

    2011-01-01

    The 153 paintings that San Antonio-based artist Mel Casas calls Humanscapes were inspired by a glimpse of a drive-in movie screen. This article treats the first three years of work on this series, a period in which the artist referenced cinematic settings and audiences while registering aspects of the sexual revolution. Marshall McLuhan's…

  14. Geologic quadrangle maps of the United States: geology of the Casa Diablo Mountain quadrangle, California

    Science.gov (United States)

    Rinehart, C. Dean; Ross, Donald Clarence

    1957-01-01

    The Casa Diablo Mountain quadrangle was mapped in the summers of 1952 and 1953 by the U.S. Geological Survey in cooperation with the California State Division of Mines as part of a study of potential tungsten-bearing areas.

  15. Thermal evaluation by means of simulation of two houses with different materials in the city of La Paz, B.C.S.; Evaluacion termica mediante simulacion de dos casas con materiales diferentes en la ciudad de la Paz, B.C.S.

    Energy Technology Data Exchange (ETDEWEB)

    Resendiz Pacheco, Oscar; Morillon Galvez, David; Chavez M, Elizabeth; Poujol G, Federico; Flores I, Alfredo [Universidad Autonoma de Baja California Sur (Mexico)

    2009-01-15

    In this article the evaluation of two houses of social interest in the city of La Paz is presented, in terms of the thermal comfort that could be offered to their users with a minimum cost of energy by means of a simulation of their thermal behavior with the program TRNSYS. One of the houses is constructed in a large extent with adobe, for the walls and brick for the ceilings and the other is a typical construction of social interest built with conventional materials. The obtained results are presented, with which some recommendations that can be made tending to improve comfort and energy saving in houses of social interest. These recommendations consider the type of material as much as the geometry of the houses. [Spanish] En este articulo se presenta la evaluacion de dos casas de interes social para la ciudad de La Paz, en terminos del confort termico que pudieran ofrecer a sus usuarios con un gasto minimo de energia mediante una simulacion de su comportamiento termico con el programa TRNSYS. Una de las casas esta construida en su mayor parte con adobe, para las paredes y ladrillo para los techos y la otra es una construccion tipica de interes social construida de materiales convencionales. Se presentan los resultados obtenidos, con los que se pueden hacer algunas recomendaciones tendientes a mejorar confort y ahorro de energia en casas de interes social. Estas recomendaciones consideran tanto el tipo de material como la geometria de las casas.

  16. Reference miRNAs for miRNAome analysis of urothelial carcinomas.

    Directory of Open Access Journals (Sweden)

    Nadine Ratert

    Full Text Available BACKGROUND/OBJECTIVE: Reverse transcription quantitative real-time PCR (RT-qPCR is widely used in microRNA (miRNA expression studies on cancer. To compensate for the analytical variability produced by the multiple steps of the method, relative quantification of the measured miRNAs is required, which is based on normalization to endogenous reference genes. No study has been performed so far on reference miRNAs for normalization of miRNA expression in urothelial carcinoma. The aim of this study was to identify suitable reference miRNAs for miRNA expression studies by RT-qPCR in urothelial carcinoma. METHODS: Candidate reference miRNAs were selected from 24 urothelial carcinoma and normal bladder tissue samples by miRNA microarrays. The usefulness of these candidate reference miRNAs together with the commonly for normalization purposes used small nuclear RNAs RNU6B, RNU48, and Z30 were thereafter validated by RT-qPCR in 58 tissue samples and analyzed by the algorithms geNorm, NormFinder, and BestKeeper. PRINCIPAL FINDINGS: Based on the miRNA microarray data, a total of 16 miRNAs were identified as putative reference genes. After validation by RT-qPCR, miR-101, miR-125a-5p, miR-148b, miR-151-5p, miR-181a, miR-181b, miR-29c, miR-324-3p, miR-424, miR-874, RNU6B, RNU48, and Z30 were used for geNorm, NormFinder, and BestKeeper analyses that gave different combinations of recommended reference genes for normalization. CONCLUSIONS: The present study provided the first systematic analysis for identifying suitable reference miRNAs for miRNA expression studies of urothelial carcinoma by RT-qPCR. Different combinations of reference genes resulted in reliable expression data for both strongly and less strongly altered miRNAs. Notably, RNU6B, which is the most frequently used reference gene for miRNA studies, gave inaccurate normalization. The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p or three (miR-148b, miR-181b, and miR-874

  17. MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.

    Directory of Open Access Journals (Sweden)

    Dong Lu

    Full Text Available miRNAs are a class of small non-coding RNAs that regulate gene expression and have critical functions in various biological processes. Hundreds of miRNAs have been identified in mammalian genomes but only a small number of them have been functionally characterized. Recent studies also demonstrate that some miRNAs have important roles in reprogramming somatic cells to induced pluripotent stem cells (iPSCs.We screened 52 miRNAs cloned in a piggybac (PB vector for their roles in reprogramming of mouse embryonic fibroblast cells to iPSCs. To identify targets of miRNAs, we made Dgcr8-deficient embryonic stem (ES cells and introduced miRNA mimics to these cells, which lack miRNA biogenesis. The direct target genes of miRNA were identified through global gene expression analysis and target validation.We found that over-expressing miR-25 or introducing miR-25 mimics enhanced production of iPSCs. We identified a number of miR-25 candidate gene targets. Of particular interest were two ubiquitin ligases, Wwp2 and Fbxw7, which have been proposed to regulate Oct4, c-Myc and Klf5, respectively. Our findings thus highlight the complex interplay between miRNAs and transcription factors involved in reprogramming, stem cell self-renewal and maintenance of pluripotency.

  18. Influence of counting chamber type on CASA outcomes of equine semen analysis.

    Science.gov (United States)

    Hoogewijs, M K; de Vliegher, S P; Govaere, J L; de Schauwer, C; de Kruif, A; van Soom, A

    2012-09-01

    Sperm motility is considered to be one of the key features of semen analysis. Assessment of motility is frequently performed using computer-assisted sperm analysis (CASA). Nevertheless, no uniform standards are present to analyse a semen sample using CASA. We hypothesised that the type of counting chamber used might influence the results of analysis and aimed to study the effect of chamber type on estimated concentration and motility of an equine semen sample assessed using CASA. Commonly used disposable Leja chambers of different depths were compared with disposable and reusable ISAS chambers, a Makler chamber and a World Health Organization (WHO) motility slide. Motility parameters and concentrations obtained with CASA using these different chambers were analysed. The NucleoCounter was used as gold standard for determining concentration. Concentration and motility parameters were significantly influenced by the chamber type used. Using the NucleoCounter as the gold standard for determining concentration, the correlation coefficients were low for all of the various chambers evaluated, with the exception of the 12 µm deep Leja chamber. Filling a chamber by capillary forces resulted in a lower observed concentration and reduced motility parameters. All chambers evaluated in this study resulted in significant lower progressive motility than the WHO prepared slide, with the exception of the Makler chamber, which resulted in a slight, but statistically significant, increase in progressive motility estimates. Computer-assisted sperm analysis can only provide a rough estimate of sperm concentration and overestimation is likely when drop-filled slides with a coverslip are used. Motility estimates using CASA are highly influenced by the counting chamber; therefore, a complete description of the chamber type used should be provided in semen reports and in scientific articles. © 2011 EVJ Ltd.

  19. Use of multivariate statistics to identify unreliable data obtained using CASA.

    Science.gov (United States)

    Martínez, Luis Becerril; Crispín, Rubén Huerta; Mendoza, Maximino Méndez; Gallegos, Oswaldo Hernández; Martínez, Andrés Aragón

    2013-06-01

    In order to identify unreliable data in a dataset of motility parameters obtained from a pilot study acquired by a veterinarian with experience in boar semen handling, but without experience in the operation of a computer assisted sperm analysis (CASA) system, a multivariate graphical and statistical analysis was performed. Sixteen boar semen samples were aliquoted then incubated with varying concentrations of progesterone from 0 to 3.33 µg/ml and analyzed in a CASA system. After standardization of the data, Chernoff faces were pictured for each measurement, and a principal component analysis (PCA) was used to reduce the dimensionality and pre-process the data before hierarchical clustering. The first twelve individual measurements showed abnormal features when Chernoff faces were drawn. PCA revealed that principal components 1 and 2 explained 63.08% of the variance in the dataset. Values of principal components for each individual measurement of semen samples were mapped to identify differences among treatment or among boars. Twelve individual measurements presented low values of principal component 1. Confidence ellipses on the map of principal components showed no statistically significant effects for treatment or boar. Hierarchical clustering realized on two first principal components produced three clusters. Cluster 1 contained evaluations of the two first samples in each treatment, each one of a different boar. With the exception of one individual measurement, all other measurements in cluster 1 were the same as observed in abnormal Chernoff faces. Unreliable data in cluster 1 are probably related to the operator inexperience with a CASA system. These findings could be used to objectively evaluate the skill level of an operator of a CASA system. This may be particularly useful in the quality control of semen analysis using CASA systems.

  20. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

    Science.gov (United States)

    Hochstrasser, Megan L; Taylor, David W; Bhat, Prashant; Guegler, Chantal K; Sternberg, Samuel H; Nogales, Eva; Doudna, Jennifer A

    2014-05-06

    In bacteria, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) DNA-targeting complex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bind complementary DNA targets at sites adjacent to a trinucleotide signature sequence called the protospacer adjacent motif (PAM). The Cascade complex then recruits Cas3, a nuclease-helicase that catalyzes unwinding and cleavage of foreign double-stranded DNA (dsDNA) bearing a sequence matching that of the crRNA. Cascade comprises the CasA-E proteins and one crRNA, forming a structure that binds and unwinds dsDNA to form an R loop in which the target strand of the DNA base pairs with the 32-nt RNA guide sequence. Single-particle electron microscopy reconstructions of dsDNA-bound Cascade with and without Cas3 reveal that Cascade positions the PAM-proximal end of the DNA duplex at the CasA subunit and near the site of Cas3 association. The finding that the DNA target and Cas3 colocalize with CasA implicates this subunit in a key target-validation step during DNA interference. We show biochemically that base pairing of the PAM region is unnecessary for target binding but critical for Cas3-mediated degradation. In addition, the L1 loop of CasA, previously implicated in PAM recognition, is essential for Cas3 activation following target binding by Cascade. Together, these data show that the CasA subunit of Cascade functions as an essential partner of Cas3 by recognizing DNA target sites and positioning Cas3 adjacent to the PAM to ensure cleavage.

  1. Additional value of computer assisted semen analysis (CASA) compared to conventional motility assessments in pig artificial insemination.

    Science.gov (United States)

    Broekhuijse, M L W J; Soštarić, E; Feitsma, H; Gadella, B M

    2011-11-01

    In order to obtain a more standardised semen motility evaluation, Varkens KI Nederland has introduced a computer assisted semen analysis (CASA) system in all their pig AI laboratories. The repeatability of CASA was enhanced by standardising for: 1) an optimal sample temperature (39 °C); 2) an optimal dilution factor; 3) optimal mixing of semen and dilution buffer by using mechanical mixing; 4) the slide chamber depth, and together with the previous points; 5) the optimal training of technicians working with the CASA system; and 6) the use of a standard operating procedure (SOP). Once laboratory technicians were trained in using this SOP, they achieved a coefficient of variation of CASA. CASA results are preferable as accurate continuous motility dates are generated rather than discrimination motility percentage increments of 10% motility as with motility estimation by laboratory technicians. The higher variability of sperm motility found with CASA and the continuous motility values allow better analysis of the relationship between semen motility characteristics and fertilising capacity. The benefits of standardised CASA for AI is discussed both with respect to estimate the correct dilution factor of the ejaculate for the production of artificial insemination (AI) doses (critical for reducing the number of sperm per AI doses) and thus to get more reliable fertility data from these AI doses in return. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. MiRNA Biogenesis and Intersecting Pathways

    DEFF Research Database (Denmark)

    Ben Chaabane, Samir

    MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Plant miRNAs are critical for plant growth, development and stress response, and are processed in Arabidopsis from primary miRNA transcripts (pri-miRNAs) by the endonuclease activity of the DICER-LIKE1...... questions need to be addressed to establish a valid link, we provide encouraging evidence of the involvement of chromatin remodeling factors FAS1 and FAS2 in miRNA biogenesis. Together, we have expanded our understanding of the intersections between miRNA biogenesis and other pathways....

  3. miRConnect: Identifying Effector Genes of miRNAs and miRNA Families in Cancer Cells

    DEFF Research Database (Denmark)

    Hua, Youjia; Duan, Shiwei; Murmann, Andrea E

    2011-01-01

    have generated custom data sets containing expression information of 54 miRNA families sharing the same seed match. We have developed a novel strategy for correlating miRNAs with individual genes based on a summed Pearson Correlation Coefficient (sPCC) that mimics an in silico titration experiment......micro(mi)RNAs are small non-coding RNAs that negatively regulate expression of most mRNAs. They are powerful regulators of various differentiation stages, and the expression of genes that either negatively or positively correlate with expressed miRNAs is expected to hold information....... By focusing on the genes that correlate with the expression of miRNAs without necessarily being direct targets of miRNAs, we have clustered miRNAs into different functional groups. This has resulted in the identification of three novel miRNAs that are linked to the epithelial-to-mesenchymal transition (EMT...

  4. Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

    Czech Academy of Sciences Publication Activity Database

    Aherne, S.T.; Madden, S.F.; Hughes, D. J.; Pardini, B.; Naccarati, A.; Levý, M.; Vodička, Pavel; Neary, P.; Dowling, P.; Clynes, M.

    2015-01-01

    Roč. 15, apr 30 (2015), s. 2-13 ISSN 1471-2407 R&D Projects: GA ČR GAP304/10/1286 Institutional support: RVO:68378041 Keywords : colorectal cancer * circulating miRNAs * miR-34a * miR-150 * miR-923 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.265, year: 2015

  5. Expression profiling of miR-96, miR-584 and miR-422a in colon ...

    African Journals Online (AJOL)

    . Lower miRNA ... Thus, the ratio of miR-96/miR-638 in plasma is a potential non- ... leading cause of cancer related deaths. ... breast cancer cells have revealed a total of 51 ... Corresponding negative control ..... The American Joint Committee.

  6. 34A, miRNA-944, miRNA-101 and miRNA-218 in cervical cancer

    African Journals Online (AJOL)

    RNAs (21 - 24 nucleotides in length) that are critical for many important processes such as development, ... RNA extraction and reverse transcription. Total RNA was extracted from each of the experimental groups using ... used as an endogenous control to normalize the expression of miRNA-143, miRNA-34A, miRNA-.

  7. VOLTA REDONDA: IMPLICAÇÕES PARA A ENFERMAGEM

    Directory of Open Access Journals (Sweden)

    Ana Emília Cardoso Moraes

    2010-01-01

    Full Text Available Este estudio tuvo como objetivo la intervención en la Casa de Saúde Volta Redonda y sus implicaciones para la enfermería psiquiátrica. Las fuentes históricas son documentos escritos y orales. La organización, clasificación y análisis de los datos se hizo según el método histórico, con el apoyo de los conceptos de habitus y campo de Pierre Bourdieu y de la bibliografía sobre la reforma psiquiátrica en Brasil. Los cambios en la política de salud mental exigieron nuevas prácticas y actitudes de acuerdo con el proceso de implementación de la reforma psiquiátrica en aquel municipio, cuyo pilar es la inserción del enfermo psiquiátrico en la comunidad y el rescate de su ciudadanía. Estas medidas forman parte de un proyecto político partidario más amplio, con experiencias en otros municipios brasileños. La Enfermería ha ganado posiciones de poder y visibilidad para asegurar su participación en diferentes espacios decisorios en el ámbito de la asistencia psiquiátrica en el municipio.

  8. Cuando el 'sufrimiento a distancia' impacta en casa

    Directory of Open Access Journals (Sweden)

    Helena Flam

    2017-07-01

    Full Text Available Este artículo trata sobre los regímenes emocionales transnacionales relacionados con el 'sufrimiento a distancia'. Se sostiene que los movimientos solidarios transnacionales del pasado fueron 'románticos' e ingenuos y que no aprendimos mucho de sus éxitos y fracasos. Tales movimientos fueron reemplazados por un nuevo régimen de compasión, así lo demuestran diversos ejemplos. El escrito vuelve entonces sobre el tema de los refugiados, discute por qué Alemania aceptó a tantos de ellos entre 2015 y 2016, y sugiere que los regímenes emocionales transnacionales relacionados con el 'sufrimiento a distancia' –es decir, que refieren al desplazamiento desde la solidaridad hacia la compasión– influirán fuertemente acerca de cómo los refugiados, en Alemania e igualmente en otros lugares, serán tratados por el pueblo de buena voluntad que los acoge.

  9. es

    Directory of Open Access Journals (Sweden)

    Esther Bernal Valls

    Full Text Available El uso de ejercicios en el tratamiento de pacientes con déficit vestibular crónico está incrementándose de forma notable, lo que evidencia que se trata de un procedimiento que resulta beneficioso para este tipo de pacientes. Los buenos resultados que se obtienen sugieren que los ejercicios vestibulares dan lugar a una estabilidad postural y a una disminución de la sensación de desequilibrio.

  10. Encuentro "Mi marca y yo"

    OpenAIRE

    Universidad de Alicante. Observatorio Comunicación en Cambio

    2013-01-01

    La gestión de la marca personal, especialmente en los entornos digitales, ha cobrado actualmente gran importancia como estrategia de posicionamiento profesional. Te invitamos a que asistas a nuestro encuentro "Mi marca y yo" para reflexionar sobre qué implica contar con una marca personal.

  11. ES-2 Dummy Biomechanical Responses.

    Science.gov (United States)

    Byrnes, Katie; Abramczyk, Joseph; Berliner, Jeff; Irwin, Annette; Jensen, Jack; Kowsika, Murthy; Mertz, Harold J; Rouhana, Stephen W; Scherer, Risa; Shi, Yibing; Sutterfield, Aleta; Xu, Lan; Tylko, Suzanne; Dalmotas, Dainius

    2002-11-01

    This technical paper presents the results of biomechanical testing conducted on the ES-2 dummy by the Occupant Safety Research Partnership and Transport Canada. The ES-2 is a production dummy, based on the EuroSID-1 dummy, that was modified to further improve testing capabilities as recommended by users of the EuroSID-1 dummy. Biomechanical response data were obtained by completing a series of drop, pendulum, and sled tests that are outlined in the International Organization of Standardization Technical Report 9790 that describes biofidelity requirements for the midsize adult male side impact dummy. A few of the biofidelity tests were conducted on both sides of the dummy to evaluate the symmetry of its responses. Full vehicle crash tests were conducted to verify if the changes in the EuroSID-1, resulting in the ES-2 design, did improve the dummy's testing capability. In addition to the biofidelity testing, the ES-2 dummy repeatability, reproducibility and durability are discussed. Finally, this technical paper will compare the biofidelity ratings of the current adult side impact dummies with the ES-2 dummy, which received an overall dummy biofidelity rating of 4.6.

  12. Influence of chamber type integrated with computer-assisted semen analysis (CASA) system on the results of boar semen evaluation.

    Science.gov (United States)

    Gączarzewicz, D

    2015-01-01

    The objective of the study was to evaluate the effect of different types of chambers used in computer-assisted semen analysis (CASA) on boar sperm concentration and motility parameters. CASA measurements were performed on 45 ejaculates by comparing three commonly used chambers: Leja chamber (LJ), Makler chamber (MK) and microscopic slide-coverslip (SL). Concentration results obtained with CASA were verified by manual counting on a Bürker hemocytometer (BH). No significant differences were found between the concentrations determined with BH vs. LJ and SL, whereas higher (p0.05). The results obtained show that CASA assessment of boar semen should account for the effect of counting chamber on the results of sperm motility and concentration, which confirms the need for further study on standardizing the automatic analysis of boar semen.

  13. Sanaa y Kazuyo Sejima. Casa en un huerto de ciruelos

    Directory of Open Access Journals (Sweden)

    Eneko Besa

    2011-05-01

    Full Text Available ES; mso-bidi-language: AR-SA;" lang="EN-US">The house in a plum grove shows the plastic language of modernism with its white and abstract image, its free façade, and its flat roof. The terrace of this house by Sejima is conceived as another habitable space of the building, since it is configured as one of the autonomous living spaces that make up the house. Double-height spaces are created with empty volumes that make up autonomous units. These units are assembled to each other, generating a highly intense spatial complexity through the division of the original pure prism. All the plane surfaces of the house work as diaphragms, mainly responding to internal stress forces having to do with buckling and warping than to vertical forces. The wall surfaces are placed creating right-angled corners and forming the different volumes that make up the house. In the corners, all three planes work to provide each other with bracing. An apparent isotropy is sought, along with a tack of distinction between horizontal and vertical planes. Through the study and observation of several models with progressive modifications, Sejima's architecture, the Sanaa office, is able to find the true concept that generates the project, which goes beyond the original sources of modernism. In conclusion, the House in a Plum Grove stands out not only for its compactness and physical coherence, but also because it marks a milestone in the development of contemporary architecture at a conceptual level.

  14. A casa de Joana Dark: drama e montagem

    Directory of Open Access Journals (Sweden)

    John Cowart Dawsey

    2012-04-01

    Full Text Available Neste artigo, ao discutir o modo como se configuram imagens de Nossa Senhora e de mães e mulheres no Jardim das Flores (ou “buraco dos capetas”, na periferia de uma cidade do interior paulista, pretende-se explorar a especificidade de estéticas dramáticas. A seguir, ainda mais do que a estética do drama social, associada à obra de Victor Turner, o princípio da montagem, que se inspira no cinema de Sergei Eisenstein, ilumina registros de cadernos de campo. E com Eisenstein - Julia Kristeva, Walter Benjamin, Michael Taussig, e Antonin Artaud. A quem se dispuser a fazer uma audição dessas mulheres, sugiro cautela. Pois em nossos ouvidos talvez ressoem os tiros de uma garrucha.While discussing images of Our Lady and of the mothers and women of the Garden of Flowers (or “Devils’ Hole”, a peripheral district of a city in the interior of São Paulo state, this paper intends to explore the specificity of dramatic aesthetics. Rather than depend upon the aesthetics of social drama, as discussed in the works of Victor Turner, the present paper deals with a concept of montage that is inspired by the cinema of Sergei Eisenstein in order to illuminate a selection of field notes... and, along with Eisenstein, Julia Kristeva, Walter Benjamin, Michael Taussig and Antonin Artaud. Wit regards to those readers interested in hearing what these women may have to say, caution is suggested, for the words of these women may ring in our ears as the sounds of musket shots.

  15. Projeto de extensão “lendo e escrevendo na casa lar”

    OpenAIRE

    Terezinha Corrêa Lindino; Rita Maria Decarli Bottega; Verônica Pereira Coutinho Constanty; Alessandra Venâncio Justino; Aline Luane Fantinel; Amanda Perin Nonose; Andréia Carla Bach Kunzler; Francine Raquel Hoff Zibetti Zimmermann; Kelly Yara Hedel; Leomir Bruch; Patrícia Helena Frai; Sônia Regina Pinheiro Corrêa; Thiago Rafael Mazzarollo; Vanessa Borella da Ross

    2014-01-01

    http://dx.doi.org/10.5007/1807-0221.2013v10n16p1 O Projeto “Lendo e Escrevendo na Casa Lar”, edição 2012, teve como objetivo desenvolver atividades de leitura, escrita e alfabetização com crianças usuárias da Casa Lar da cidade de Marechal Cândido Rondon. Elaborado pela equipe pedagógica do Núcleo de Estudos e Defesa dos Direitos da Infância e da Juventude (NEDDIJ), em parceria com o Grupo de Estudo e Pesquisa em Formação de Professores (GEPEFOP), o Núcleo de Formação Docente e Prática de...

  16. Bartolomé de las Casas y Michel de Montaigne: Escritura y lectura del Nuevo Mundo

    Directory of Open Access Journals (Sweden)

    Juan Durán Luzio

    2016-04-01

    Full Text Available Se trata de mostrar cómo la obra de Bartolomé de Las Casas, Brevísima relación de la destrucción de las Indias, publicada en 1552 y traducida al francés en 1579,fue leída por Michel de Montaigne e incorporada en sus párrafos y doctrinas más relevantes en sus dos ensayos sobre el Nuevo Mundo: "Des Cannibales" (1580 y "Des Coches" (1588.   The work of Bartolomé de Las Casas Brevísima relación de la destrucción de las Indias, published in 1552 and translated into French in 1579, is shown to have been read by Michel de Montaigne who included it in the most relevant paragraphs and doctrines in his two essays about the new world: "Des Cannibales" (1850 and "Des Coches" (1588.

  17. Bartolomé de las Casas y Michel de Montaigne: Escritura y lectura del Nuevo Mundo

    OpenAIRE

    Juan Durán Luzio

    2016-01-01

    Se trata de mostrar cómo la obra de Bartolomé de Las Casas, Brevísima relación de la destrucción de las Indias, publicada en 1552 y traducida al francés en 1579,fue leída por Michel de Montaigne e incorporada en sus párrafos y doctrinas más relevantes en sus dos ensayos sobre el Nuevo Mundo: "Des Cannibales" (1580) y "Des Coches" (1588).   The work of Bartolomé de Las Casas Brevísima relación de la destrucción de las Indias, published in 1552 and translated into French in 1579, is sho...

  18. Relatório de Estágio em La Casa Amarilla (Barcelona)

    OpenAIRE

    Serrazina, Catarina Lopes

    2013-01-01

    Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Práticas Culturais para Municípios Este relatório procura apresentar os resultados das 570 horas de estágio em La Casa Amarilla e lançar uma base de reflexão acerca da pertinência que entidades como aquela que acolheu o estágio possuem nas cidades que as albergam. La Casa Amarilla é uma associação cultural sem fins lucrativos, com estatuto de organização não governamental, sediada e...

  19. Antropologia visuale dei senza casa di Place de la Réunion

    Directory of Open Access Journals (Sweden)

    Sylvaine Conord

    2008-07-01

    Full Text Available Questo quartiere negli anni 90 veniva considerato una zona prevalentemente popolare. Oggi resta l’esempio emblematico di una Parigi popolare in mutamento. Questa ricerca è sempre attuale grazie al soggetto: i senza casa. La questione dei senza casa nella regione parigina non è risolta: migliaia di nuclei familiari attendono l'assegnazione di un alloggio abitabile. Numerose famiglie vivono in palazzi occupati, nonostante abbiano presentato presso i servizi pubblici la loro domanda da molti anni. Quindi, oltre ad un osservazione partecipante, questo lavoro pone l’accento "su una sociologia militante" che prende corpo attraverso le testimonianze e la partecipazione attiva dell'osservatrice alle diverse situazioni che vive e vede.

  20. Some tests of wet tropospheric calibration for the CASA Uno Global Positioning System experiment

    Science.gov (United States)

    Dixon, T. H.; Wolf, S. Kornreich

    1990-01-01

    Wet tropospheric path delay can be a major error source for Global Positioning System (GPS) geodetic experiments. Strategies for minimizing this error are investigted using data from CASA Uno, the first major GPS experiment in Central and South America, where wet path delays may be both high and variable. Wet path delay calibration using water vapor radiometers (WVRs) and residual delay estimation is compared with strategies where the entire wet path delay is estimated stochastically without prior calibration, using data from a 270-km test baseline in Costa Rica. Both approaches yield centimeter-level baseline repeatability and similar tropospheric estimates, suggesting that WVR calibration is not critical for obtaining high precision results with GPS in the CASA region.

  1. O mito do gaúcho em A casa das sete mulheres

    Directory of Open Access Journals (Sweden)

    Menger, Amanda da Silva

    2011-01-01

    Full Text Available O presente artigo, O mito do gaúcho em A Casa das Sete Mulheres, trata do mito do gaúcho. Aborda desde o seu conceito, a sua formação até a perpetuação. Para isso, o trabalho faz uma retomada histórica do gaúcho, entre o pária e o herói e a influência da História e das Tecnologias do Imaginário, teoria proposta por Juremir Machado da Silva (2003, para esta mudança. O artigo também trata da imagem do gaúcho apresentada pela minissérie A Casa das Sete Mulheres

  2. Lo peculiar de los seres humanos no es la razón, sino la voluntad libre

    Directory of Open Access Journals (Sweden)

    PASCUAL F. MARTÍNEZ-FREIRE

    2015-02-01

    Full Text Available Mi tesis es que los seres humanos son agentes racionales pero no pueden ser definidos como los agentes racionales. Las ciencias cognitivas (psicología y neurociencia, y también la inteligencia artificial nos dicen que algunos animales y algunas máquinas son asimismo agentes racionales. En mi opinión el rasgo más característico de mujeres y hombres no es su dimensión racional sino su dimensión volicional, es decir, su aspecto de ser agentes libres. Es precisamente en este aspecto volicional donde encontramos los procesos mentales que muy probablemente son no-físicos (y quizás espirituales.

  3. Chimenea and other tools: Automated imaging of multi-epoch radio-synthesis data with CASA

    Science.gov (United States)

    Staley, T. D.; Anderson, G. E.

    2015-11-01

    In preparing the way for the Square Kilometre Array and its pathfinders, there is a pressing need to begin probing the transient sky in a fully robotic fashion using the current generation of radio telescopes. Effective exploitation of such surveys requires a largely automated data-reduction process. This paper introduces an end-to-end automated reduction pipeline, AMIsurvey, used for calibrating and imaging data from the Arcminute Microkelvin Imager Large Array. AMIsurvey makes use of several component libraries which have been packaged separately for open-source release. The most scientifically significant of these is chimenea, which implements a telescope-agnostic algorithm for automated imaging of pre-calibrated multi-epoch radio-synthesis data, of the sort typically acquired for transient surveys or follow-up. The algorithm aims to improve upon standard imaging pipelines by utilizing iterative RMS-estimation and automated source-detection to avoid so called 'Clean-bias', and makes use of CASA subroutines for the underlying image-synthesis operations. At a lower level, AMIsurvey relies upon two libraries, drive-ami and drive-casa, built to allow use of mature radio-astronomy software packages from within Python scripts. While targeted at automated imaging, the drive-casa interface can also be used to automate interaction with any of the CASA subroutines from a generic Python process. Additionally, these packages may be of wider technical interest beyond radio-astronomy, since they demonstrate use of the Python library pexpect to emulate terminal interaction with an external process. This approach allows for rapid development of a Python interface to any legacy or externally-maintained pipeline which accepts command-line input, without requiring alterations to the original code.

  4. THE ROLE OF EMPLOYEE PERFORMANCE APPRAISAL AT CASA DE LA ROSA TIMISOARA

    Directory of Open Access Journals (Sweden)

    SILVIA VLAD

    2015-04-01

    Full Text Available The purpose of this research is to analyze the most important aspects of employee performance appraisal role in a hotel. The research is based on highlighting the major aspects of employee performance appraisal at Casa de la Rosa Hotel and aims the aspects related to the hotel performance. The aim of this evaluation is to observe and to analyze the employee time evolution and the way they complete their tasks and their job requirements.

  5. Radar search and detection with the CASA 212 S43 aircraft

    OpenAIRE

    Landa Borges, José Manuel

    2004-01-01

    Approved for public release; distribution in unlimited. This research develops a detection rate model to analyze the effectiveness of the RDR 1500B search radar installed in the CASA 212 S43 aircraft belonging to Venezuelan Naval Aviation. The model is based on a search and detection mission to find a diesel submarine executing an incursion inside the Venezuelan Caribbean Sea area, assumed to be intermittently operating with periscopes or masts exposed above the sea surface. The analysis o...

  6. Casa Santos Lima : from “Business as Usual” to “Expand”

    OpenAIRE

    Sabido, João Oliveira da Silva

    2016-01-01

    The case study aims to evaluate the strategy formulation of Casa Santos Lima (CSL), a Portuguese wine company, whose profile and competitive business were very useful to discuss and recommend overall strategic priorities that should guide CLS’s development and overcome with success rather challenging times ahead. From a traditional wine farm located in Alenquer, in the denominated wine producer area of Lisbon, CSL implemented a philosophy of management based on high quality ...

  7. miRNAs in brain development

    International Nuclear Information System (INIS)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-01-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function

  8. Las revistas de tu casa: una provocación para innovar en la difusión académica

    Directory of Open Access Journals (Sweden)

    Mauricio Andión Gamboa

    2005-01-01

    Full Text Available Desde principios del siglo pasado, las universidades latinoamericanas han mostrado una vocación “extensionista”, es decir, un afán de difusión de la cultura científica y humanística más allá de los confines de las comunidades académicas. Las revistas y los libros han sido tradicionalmente la principal vía que las universidades han utilizado para difundir su producción cultural entre sus comunidades y la sociedad en general. La Galaxia de Gutenberg es sumamente extensa y, aún hoy, las universidades no han terminado de cruzarla. Las revistas universitarias son más que un medio de difusión, de hecho son proyectos académicos, la mayoría de ellos, que aglutinan grupos de interés integrados por afinidad ideológica, política, social o cultural. Para propiciar la discusión, se elaboró un video documental titulado “Las revistas de tu casa” que aborda la problemática actual de las revistas en la Universidad Autónoma Metropolitana (UAM, en su conjunto, y dentro del cambio de paradigma tecnológico.

  9. Graffiti: una expresión político-cultural juvenil en San Cristóbal de Las Casas, Chiapas, México

    Directory of Open Access Journals (Sweden)

    Jesús Gómez-Abarca

    2014-07-01

    Full Text Available El objetivo en este artículo es ayudar a comprender los componentes políticos y culturales asociados al desarrollo del graffiti en San Cristóbal de Las Casas. Realicé la investigación entre los años 2010 y 2012, desde el paradigma cualitativo, basado en la interpretación de registros etnográficos y entrevistas con sus productores y productoras. El graffiti emerge en esta ciudad desde la década de los noventa del siglo pasado, como una producción cultural, en torno a la cual las y los jóvenes construyen identidades individuales y colectivas; representan sus realidades, se (reapropian de los espacios públicos, cuestionan el ordenamiento socio-espacial y generan disputas por la definición del paisaje urbano. Con base en estos resultados concluyo que el graffiti es un producto cultural complejo a través del cual las y los jóvenes se posicionan como sujetos políticoculturales.

  10. Usefulness of hemocytometer as a counting chamber in a computer assisted sperm analyzer (CASA)

    Science.gov (United States)

    Eljarah, A.; Chandler, J.; Jenkins, J.A.; Chenevert, J.; Alcanal, A.

    2013-01-01

    Several methods are used to determine sperm cell concentration, such as the haemocytometer, spectrophotometer, electronic cell counter and computer-assisted semen analysers (CASA). The utility of CASA systems has been limited due to the lack of characterization of individual systems and the absence of standardization among laboratories. The aims of this study were to: 1) validate and establish setup conditions for the CASA system utilizing the haemocytometer as a counting chamber, and 2) compare the different methods used for the determination of sperm cell concentration in bull semen. Two ejaculates were collected and the sperm cell concentration was determined using spectrophotometer and haemocytometer. For the Hamilton-Thorn method, the haemocytometer was used as a counting chamber. Sperm concentration was determined three times per ejaculate samples. A difference (P 0.05) or between the haemocytometer count and the spectrophotometer. Based on the results of this study, we concluded that the haemocytometer can be used in computerized semen analysis systems as a substitute for the commercially available disposable counting chambers, therefore avoiding disadvantageous high costs and slower procedures.

  11. Sperm motility in fish: technical applications and perspectives through CASA-Mot systems.

    Science.gov (United States)

    Gallego, V; Asturiano, J F

    2018-03-09

    Although a relatively high number of sperm quality biomarkers have been reported over the years in several fish species, sperm motility is nowadays considered the best biomarker for fish spermatozoa. The first scientific reports focusing on fish sperm motility date from a century ago, but the objective assessment allowed by computer-aided sperm analysis (CASA-Mot) systems was not applied to fish species until the mid-1980s. Since then, a high number of sperm kinetic parameters from more than 170 fish species have been reported in more than 700 scientific articles, covering a wide range of topics, such as sperm physiology, sperm storage, broodstock management, the phenomenon of sperm competition, ecotoxicology and understanding the life cycle of the species. The sperm kinetic parameters provided by CASA-Mot systems can serve as powerful and useful tools for aquaculture and ecological purposes, and this review provides an overview of the major research areas in which fish sperm motility assessment by a CASA-Mot system has been used successfully.

  12. Selective degradation of the recalcitrant cell wall of Scenedesmus quadricauda CASA CC202.

    Science.gov (United States)

    Reshma, Ragini; Arumugam, Muthu

    2017-10-01

    An eco-friendly cell wall digestion strategy was developed to enhance the availability of nutritionally important bio molecules of edible microalgae and exploit them for cloning, transformation, and expression of therapeutic proteins. Microalgae are the source for many nutritionally important bioactive compounds and potential drugs. Even though edible microalgae are rich in nutraceutical, bioavailability of all these molecules is very less due to their rigid recalcitrant cell wall. For example, the cell wall of Scenedesmus quadricauda CASA CC202 is made up of three layers comprising of rigid outer pectin and inner cellulosic layer separated by a thin middle layer. In the present investigation, a comprehensive method has been developed for the selective degradation of S. quadricauda CASA CC202 cell wall, by employing both mechanical and enzymatic treatments. The efficiency of cell wall removal was evaluated by measuring total reducing sugar (TRS), tannic acid-ferric chloride staining, calcoflour white staining, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) analysis. It was confirmed that the yield of TRS increased from 129.82 mg/g in 14 h from pectinase treatment alone to 352.44 mg/g by combined sonication and enzymatic treatment within 12 h. As a result, the combination method was found to be effective for the selective degradation of S. quadricauda CASA CC202 cell wall. This study will form a base for our future works, where this will help to enhance the digestibility and availability of nutraceutically important proteins.

  13. Evaluation of sperm motility with CASA-Mot: which factors may influence our measurements?

    Science.gov (United States)

    Yeste, Marc; Bonet, Sergi; Rodríguez-Gil, Joan E; Rivera Del Álamo, Maria M

    2018-03-14

    Computer-aided sperm analysis (CASA) is now routinely used in IVF clinics, animal breeding centres and research laboratories. Although CASA provides a more objective way to evaluate sperm parameters, a significant number of factors can affect these measurements. This paper classifies these factors into four categories: (1) sample and slide (e.g. preincubation time, type of specimen and type of chamber slide); (2) microscope (e.g. light source and microscope stage); (3) hardware and software, including the settings of each system; and (4) user-related factors. We review the effects of the different factors in each category on the measurements made and emphasise the need to take measures to standardise evaluations. The take-home message of the present article is that there are several commercial and useful CASA systems, and all are appropriate for routine analysis. Non-commercial systems may also be good choices when the user needs to adapt the device to specific experimental conditions. In both cases (commercial and non-commercial), it is important that standard protocols are put in place for evaluation, as well as methods to validate the system.

  14. CASA : oil and gas industry perspective : flaring : case study of success

    International Nuclear Information System (INIS)

    Pryce, D.

    2002-01-01

    A brief overview of the Canadian Association of Petroleum Producers (CAPP) and its mission is provided at the beginning of this presentation. The importance of flaring is explained, as it represents a safety precaution in the event of an emergency or process upset. It is also an important part of operations, and is valuable in well test evaluations for gathering information as part of the facility design process. Some of the major issues associated with flaring are reviewed, namely flare performance; concerns related to health risks, odour, visibility, greenhouse gases, resource conservation; the position of the Energy and Utilities Board (EUB), and the need of the industry for regulatory certainty. The Clean Air Strategic Alliance (CASA) was commissioned by the CAPP to examine the issue of flaring in November 1996 as part of the CASA flaring project team. The key recommendations of the CASA flaring team project were submitted in 1998 and included: focus on solution gas at oil batteries, the establishment of a new management framework. The author presents the Alberta provincial policy objective with regard to flaring. The best management practices decision tree is explained, along with management tools, which were incorporated in a new guide for flaring issued in July 1999 by the Alberta Energy and Utilities Board. The reduction targets are reviewed, and the author explains the rationale for the industry support of the recommendations. The progress to date is reviewed, and the next steps in the ongoing process are described, such as the formal progress review currently underway

  15. A vivência do cuidado familiar em casas transitórias de apoio

    Directory of Open Access Journals (Sweden)

    Jaqueline Dias do Nascimento

    2016-06-01

    Full Text Available RESUMO Objetivo: apresentar modelo teórico representativo da vivência do cuidado em casas transitórias de apoio a familiares de crianças em pós-transplante de células-tronco hematopoiéticas. Método: Teoria Fundamentada nos Dados, realizada com 18 participantes de três grupos amostrais. Para análise, utilizou-se o software QSR Nvivo10. Resultados: elaboraram-se quatro categorias: residindo em casa transitória de apoio; vivenciando o cuidado à criança em pós-transplante de células-tronco hematopoiéticas; cuidando do cuidador familiar; e retornando a uma nova vida no lar, as quais se inter-relacionam conforme o código teórico da família interativa. Conclusão: esta pesquisa contribui para compreensão da vivência do cuidado em casas transitórias de apoio a familiares de crianças em pós-transplante de células-tronco hematopoiéticas e subsidia as ações de enfermagem e saúde prestadas a esta população; contribui ainda para a elaboração de orientação de alta hospitalar e cuidado direcionado a essa clientela.

  16. El uso de los presupuestos en la Casa ducal de Osuna (1860-69

    Directory of Open Access Journals (Sweden)

    Jesús Damián López Manjón

    2006-12-01

    El trabajo se basa en la descripción y el análisis de fuentes primarias conservadas en la Sección Nobleza del Archivo Histórico Nacional y en el Archivo Histórico de Protocolos de Madrid. La discusión permite, por un lado, conocer la situación de la Casa ducal a partir del presupuesto de 1862. Por otro lado, se presenta el debate surgido en la organización acerca del empleo de presupuestos, enfrentándose posturas reacias a su uso, intentos de implantarlos como una herramienta para la gestión de la Casa y presiones para que se usaran como limitaciones del gasto. Siendo esta última, la postura que logró imponerse, el debate sobre el uso de los presupuestos en la Casa se produjo en paralelo a la dialéctica política entre liberales y conservadores que caracterizó a la España del siglo XIX y al auge de la burguesía liberal.

  17. El Programa de Educación en Alimentación y Nutrición (1961-1982) y la capacitación de las amas de casa como responsables del bienestar familiar The food and nutrition program (1961-1982) and the training of housewives as family welfare managers

    OpenAIRE

    E. M.ª Trescastro López; M.ª E. Galiana Sánchez; J. Bernabeu-Mestre

    2012-01-01

    El objetivo de este trabajo es analizar desde una perspectiva de género, a través del ejemplo del Programa de Educación en Alimentación y Nutrición (EDALNU) que se desarrolló en España en las décadas finales del siglo XX, los mensajes y estrategias de educación alimentaria nutricional que iban dirigidos a mejorar la capacitación de las amas de casa como garantes del bienestar familiar y como expertas en la gestión de los diversos aspectos del hogar. Su acción específica sobre las amas de casa...

  18. Potential role of miR-9 and miR-223 in recurrent ovarian cancer

    Directory of Open Access Journals (Sweden)

    McGuinness Eamonn

    2008-04-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable disease. Results Using real-time RT-PCR, we obtained distinct miRNA expression profiles between primary and recurrent serous papillary ovarian adenocarcinomas (n = 6 in a subset of samples previously used in a transcriptome approach. Expression levels of top dysregulated miRNA genes, miR-223 and miR-9, were examined using TaqMan PCR in independent cohorts of fresh frozen (n = 18 and FFPE serous ovarian tumours (n = 22. Concordance was observed on TaqMan analysis for miR-223 and miR-9 between the training cohort and the independent test cohorts. Target prediction analysis for the above miRNA "recurrent metastatic signature" identified genes previously validated in our transcriptome study. Common biological pathways well characterised in ovarian cancer were shared by miR-9 and miR-223 lists of predicted target genes. We provide strong evidence that miR-9 acts as a putative tumour suppressor gene in recurrent ovarian cancer. Components of the miRNA processing machinery, such as Dicer and Drosha are not responsible for miRNA deregulation in recurrent ovarian cancer, as deluded by TaqMan and immunohistochemistry. Conclusion We propose a miRNA model for the molecular pathogenesis of recurrent ovarian cancer. Some of the differentially deregulated miRNAs identified correlate with our previous transcriptome findings. Based on integrated transcriptome and miRNA analysis, miR-9 and miR-223 can be of potential importance as biomarkers in recurrent ovarian cancer.

  19. Bioinformatics of cardiovascular miRNA biology.

    Science.gov (United States)

    Kunz, Meik; Xiao, Ke; Liang, Chunguang; Viereck, Janika; Pachel, Christina; Frantz, Stefan; Thum, Thomas; Dandekar, Thomas

    2015-12-01

    MicroRNAs (miRNAs) are small ~22 nucleotide non-coding RNAs and are highly conserved among species. Moreover, miRNAs regulate gene expression of a large number of genes associated with important biological functions and signaling pathways. Recently, several miRNAs have been found to be associated with cardiovascular diseases. Thus, investigating the complex regulatory effect of miRNAs may lead to a better understanding of their functional role in the heart. To achieve this, bioinformatics approaches have to be coupled with validation and screening experiments to understand the complex interactions of miRNAs with the genome. This will boost the subsequent development of diagnostic markers and our understanding of the physiological and therapeutic role of miRNAs in cardiac remodeling. In this review, we focus on and explain different bioinformatics strategies and algorithms for the identification and analysis of miRNAs and their regulatory elements to better understand cardiac miRNA biology. Starting with the biogenesis of miRNAs, we present approaches such as LocARNA and miRBase for combining sequence and structure analysis including phylogenetic comparisons as well as detailed analysis of RNA folding patterns, functional target prediction, signaling pathway as well as functional analysis. We also show how far bioinformatics helps to tackle the unprecedented level of complexity and systemic effects by miRNA, underlining the strong therapeutic potential of miRNA and miRNA target structures in cardiovascular disease. In addition, we discuss drawbacks and limitations of bioinformatics algorithms and the necessity of experimental approaches for miRNA target identification. This article is part of a Special Issue entitled 'Non-coding RNAs'. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Es Mi Vida (It’s Your Life)

    Centers for Disease Control (CDC) Podcasts

    2007-11-01

    This podcast uses music with a Latino beat to promote making healthy lifestyle choices. (Este podcast usa música con ritmo latinos para promover la selección de estilos de vida saludables.).  Created: 11/1/2007 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 12/1/2007.

  1. "Mi Historia Familiar Es Sencilla" ("My Family History Is Simple"): Testimonio in the New Latino Diaspora

    Science.gov (United States)

    McClure, Greg; Fitts, Shanan

    2018-01-01

    In this paper, we share the testimonio of Santana, an immigrant from rural México, who explained the ways that she navigates her life and raises her children as a Latina immigrant woman here in the southeastern United States. Our inquiry is guided by analysis of ethnographic interviews conducted with Santana over a period of three years. We argue…

  2. Measurement of target and double-spin asymmetries for the <mi>e><mi>pmi><mi>emi><mimi>+(<mi>n>) reaction in the nucleon resonance region at low <mi>Q>2

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, X.; Adhikari, K. P.; Bosted, P.; Deur, A.; Drozdov, V.; El Fassi, L.; Kang, Hyekoo; Kovacs, K.; Kuhn, S.; Long, E.; Phillips, S. K.; Ripani, M.; Slifer, K.; Smith, L. C.; Adikaram, D.; Akbar, Z.; Amaryan, M. J.; Anefalos Pereira, S.; Asryan, G.; Avakian, H.; Badui, R. A.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Briscoe, W. J.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Chen, J. -P.; Chetry, T.; Choi, Seonho; Ciullo, G.; Clark, L.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Crede, V.; D' Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Djalali, C.; Dodge, G. E.; Dupre, R.; Egiyan, H.; El Alaoui, A.; Elouadrhiri, L.; Eugenio, P.; Fanchini, E.; Fedotov, G.; Fersch, R.; Filippi, A.; Fleming, J. A.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gleason, C.; Golovach, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jenkins, D.; Jiang, H.; Jo, H. S.; Joosten, S.; Keller, D.; Khachatryan, G.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Kubarovsky, V.; Lanza, L.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Markov, N.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Movsisyan, A.; Munevar, E.; Munoz Camacho, C.; Murdoch, G.; Nadel-Turonski, P.; Net, L. A.; Ni, A.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Peng, P.; Pisano, S.; Pogorelko, O.; Price, J. W.; Puckett, A. J. R.; Raue, B. A.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schumacher, R. A.; Sharabian, Y. G.; Skorodumina, Iu.; Smith, G. D.; Sokhan, D.; Sparveris, N.; Stankovic, I.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tian, Ye; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zhang, J.; Zonta, I.

    2016-10-01

    We report measurements of target- and double-spin asymmetries for the exclusive channel <mi>e><mi>pmi><mi>emi><mimi>+(<mi>n>) in the nucleon resonance region at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). These asymmetries were extracted from data obtained using a longitudinally polarized NH3 target and a longitudinally polarized electron beam with energies 1.1, 1.3, 2.0, 2.3, and 3.0 GeV. The new results are consistent with previous CLAS publications but are extended to a low Q2 range from 0.0065 to 0.35 (GeV/c)2. The Q2 access was made possible by a custom-built Cherenkov detector that allowed the detection of electrons for scattering angles as low as 6 degrees. These results are compared with the unitary isobar models JANR and MAID, the partial-wave analysis prediction from SAID, and the dynamic model DMT. In many kinematic regions our results, in particular results on the target asymmetry, help to constrain the polarization-dependent components of these models.

  3. Perspectives on Sámi historiography

    Directory of Open Access Journals (Sweden)

    Lars Ivar Hansen

    2017-09-01

    Full Text Available The article focuses on Sámi history and historical methods. The main results and central aspects of Sámi history, in its relational context, are gone through. What effects and consequences — regarding both methodology and narrative styles — these aspects have had, and ought to have, for the processes of doing research on and writing Sámi history? The focus is on the politics of Sámi history and research. The issues, who is “allowed” to write Sámi history and the way Sámi research is demanded to stand in the service of different societal-cultural needs of the Sámi is dealt with. This expectation of applicability concerns Sámi history in general, and the more delimited efforts of presenting situated accounts of Sámi cultural practices, traditions and experience with relations to other folk groups. Finally, methodological considerations and recommendations of Sámi history are presented, in which a number of methodological competences and in-depth usage of numerous source categories are called for.

  4. Jurisdicción y solar. Poder, rentas y patrimonio de la casa de Grajal en la Edad Moderna

    Directory of Open Access Journals (Sweden)

    Laureano M. RUBIO PÉREZ

    2009-12-01

    Full Text Available RESUMEN: El presente artículo se enmarca en un proyecto más amplio que centrado en los señoríos y en el régimen señorial del Reino de León pretende profundizar tanto en el conocimiento de las diferentes casas nobiliarias, como en la incidencia que su dominio señorial tuvo en el desarrollo histórico y en el conjunto social de las comunidades concejiles leonesas sobre las que imponen su poder jurisdiccional. A partir de una serie de datos cuantitativos y de la información ofrecida por la documentación notarial hemos podido conocer tanto la dinámica familiar y el patrimonio de la Casa de Grajal, como la tipología y el nivel de ingresos procedentes de las rentas de los diferentes mayorazgos que ostentaron los señores, posteriormente condes de Grajal, hasta su incorporación en el siglo XVIII al marquesado de Alcañices. Dos rasgos fundamentales aparecen como definidores de un modelo de señorío en el que determinadas rentas feudales se intentan disfrazar bajo la cobertura de un supuesto dominio territorial cuya titularidad es difícil de probar fuera del feudo: los fueros concejiles que, sobre la base de antiguos censos de frutos, se convierten en foros enfitéuticos colectivos y la confrontación entre un poder señorial jurisdiccional y el poder político concejil que sobre la base del derecho consuetudinario se mantiene aún fuerte en el seno de estas villas rurales y que en cierto modo justifica la acción colectiva ante los frecuentes conflictos antiseñoriales.ABSTRACT: This work is part of a wider Project focussed on fiefs and feudal regime in the kingdom of Leon, that tries to enhance our knowledge of both the different noble houses and the influence that their lordship had in the historical and social development of the communities ruled by councils {Concejos, over which they exercised jurisdictional powers. Thanks to a series of quantitative data and to the information obtained from the records of notaries, we have grasped

  5. The perspectives of Brazilian homemakers concerning living with type 2 diabetes mellitus La perspectiva de ama de casa brasileña sobre la vida con diabetes mellitus tipo 2 As perspectivas de donas de casa brasileiras sobre a sua experiência com diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Denise Maria Guerreiro Vieira da Silva

    2012-06-01

    Full Text Available The purpose of this study is to present an understanding of the experience of Brazilian homemakers with type 2 diabetes mellitus (DM2. A descriptive exploratory design was used and semi-structured interviews were conducted with 25 Brazilian homemakers concerning their experience. The interviews were recorded, transcribed, and the resulting text was analyzed using the sequential step method. Data converged to one dominant category, "constructing one's identity in the family context", which is comprised of three categories: gender differences; day-to-day concerns; and incongruity between knowledge and behavior related to DM2. These findings suggest that participants construct their identities within the family context and that their experience of living with DM2 is integral to their self-identification as wives and mothers. This, in turn, has implications for the design and implementation of programs to assist women in managing DM2 effectively.El propósito de este estudio es comprender la experiencia de las amas de casa brasileñas con la diabetes mellitus tipo 2 (DM2. Se empleo un abordaje exploratorio descriptivo, donde participaron de las entrevistas 25 amas de casa de Brasil acerca de su experiencia con el DM. Las entrevistas fueron grabadas, transcritas y el texto resultante se analizó mediante el método secuencial de cuatro etapas: aprensión, síntesis, teorización y transferencia. Los datos se reunieron en un tema dominante: "construyendo su identidad en el contexto familiar", que se compone de tres sub-temas: las diferencias de género, las preocupaciones del cotidiano y la incongruencia entre el conocimiento y el comportamiento relacionado con DM2. Estos hallazgos sugieren que los participantes construyen su propia identidad dentro del contexto familiar y que su experiencia de vivir con DM2 es parte integral de su identificación como esposas y madres. Esto, a su vez, tiene implicaciones para el planeamiento e implementación de

  6. miRiadne: a web tool for consistent integration of miRNA nomenclature.

    Science.gov (United States)

    Bonnal, Raoul J P; Rossi, Riccardo L; Carpi, Donatella; Ranzani, Valeria; Abrignani, Sergio; Pagani, Massimiliano

    2015-07-01

    The miRBase is the official miRNA repository which keeps the annotation updated on newly discovered miRNAs: it is also used as a reference for the design of miRNA profiling platforms. Nomenclature ambiguities generated by loosely updated platforms and design errors lead to incompatibilities among platforms, even from the same vendor. Published miRNA lists are thus generated with different profiling platforms that refer to diverse and not updated annotations. This greatly compromises searches, comparisons and analyses that rely on miRNA names only without taking into account the mature sequences, which is particularly critic when such analyses are carried over automatically. In this paper we introduce miRiadne, a web tool to harmonize miRNA nomenclature, which takes into account the original miRBase versions from 10 up to 21, and annotations of 40 common profiling platforms from nine brands that we manually curated. miRiadne uses the miRNA mature sequence to link miRBase versions and/or platforms to prevent nomenclature ambiguities. miRiadne was designed to simplify and support biologists and bioinformaticians in re-annotating their own miRNA lists and/or data sets. As Ariadne helped Theseus in escaping the mythological maze, miRiadne will help the miRNA researcher in escaping the nomenclature maze. miRiadne is freely accessible from the URL http://www.miriadne.org. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  7. "Nada es más hermoso que conocer": Lastanosa, entre el anticuarismo y la erudición

    Directory of Open Access Journals (Sweden)

    María Almudena Domínguez Arranz

    2008-01-01

    Full Text Available En el Siglo de Oro asistimos a un coleccionismo que se orienta a reunir curiosidades o piezas antiguas que se despliega en la corte y en ambientes cultos. Es un interés estético lo que guía a los eruditos a incorporar artefactos y obras de arte del pasado para embellecer casas y jardines, pero también es afán de conocer. En su Wunderkammer, que frecuentaban personajes como Baltasar Gracián, Lastanosa disponía de tratados sobre antigu?edad y numismática. Él mismo compuso manuscritos y editó dos obras: el Museo de las medallas desconocidas españolas, sobre moneda antigua, y el Tratado de la moneda jaquesa, sobre moneda medieval y moderna aragonesa.

  8. The miRNome of bipolar disorder.

    Science.gov (United States)

    Fries, Gabriel R; Carvalho, Andre F; Quevedo, Joao

    2018-06-01

    Epigenetic mechanisms have been suggested to play a key role in the pathophysiology of bipolar disorder (BD), among which microRNAs (miRNAs) may be of particular significance according to recent studies. We aimed to summarize miRNA studies in BD to identify consistent findings, limitations, and future directions of this emerging field. We performed a comprehensive search on PUBMED and Medline for studies investigating an association between BD and miRNAs. The included studies report miRNA alterations in postmortem brain tissues and in the periphery, cell culture and preclinical findings, genetic associations, and the effects of medications. Several studies report changes in miRNA expression levels in postmortem brain and in the periphery of patients, although most of the results so far have not been replicated and are not concordant between different populations. Genetic studies also suggest that miRNA genes are located within susceptibility loci of BD, and also a putative role of miRNAs in modulating genes previously shown to confer risk of BD. We did not perform a systematic review of the literature, and miRNAs represent only one facet of the plethora of epigenetic mechanisms that might be involved in BD's pathophysiology. miRNA findings in BD significantly vary between studies, but are consistent to suggest a key role for these molecules in BD's pathophysiology and treatment, particularly miR-34a and miR-137. Accordingly, miRNA might represent important biomarkers of illness to be used in the clinical settings, and potentially also for the development of novel therapeutics for BD in the near future. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Modification of computational auditory scene analysis (CASA) for noise-robust acoustic feature

    Science.gov (United States)

    Kwon, Minseok

    While there have been many attempts to mitigate interferences of background noise, the performance of automatic speech recognition (ASR) still can be deteriorated by various factors with ease. However, normal hearing listeners can accurately perceive sounds of their interests, which is believed to be a result of Auditory Scene Analysis (ASA). As a first attempt, the simulation of the human auditory processing, called computational auditory scene analysis (CASA), was fulfilled through physiological and psychological investigations of ASA. CASA comprised of Zilany-Bruce auditory model, followed by tracking fundamental frequency for voice segmentation and detecting pairs of onset/offset at each characteristic frequency (CF) for unvoiced segmentation. The resulting Time-Frequency (T-F) representation of acoustic stimulation was converted into acoustic feature, gammachirp-tone frequency cepstral coefficients (GFCC). 11 keywords with various environmental conditions are used and the robustness of GFCC was evaluated by spectral distance (SD) and dynamic time warping distance (DTW). In "clean" and "noisy" conditions, the application of CASA generally improved noise robustness of the acoustic feature compared to a conventional method with or without noise suppression using MMSE estimator. The intial study, however, not only showed the noise-type dependency at low SNR, but also called the evaluation methods in question. Some modifications were made to capture better spectral continuity from an acoustic feature matrix, to obtain faster processing speed, and to describe the human auditory system more precisely. The proposed framework includes: 1) multi-scale integration to capture more accurate continuity in feature extraction, 2) contrast enhancement (CE) of each CF by competition with neighboring frequency bands, and 3) auditory model modifications. The model modifications contain the introduction of higher Q factor, middle ear filter more analogous to human auditory system

  10. Automated analysis of calcium spiking profiles with CaSA software: two case studies from root-microbe symbioses.

    Science.gov (United States)

    Russo, Giulia; Spinella, Salvatore; Sciacca, Eva; Bonfante, Paola; Genre, Andrea

    2013-12-26

    Repeated oscillations in intracellular calcium (Ca2+) concentration, known as Ca2+ spiking signals, have been described in plants for a limited number of cellular responses to biotic or abiotic stimuli and most notably the common symbiotic signaling pathway (CSSP) which mediates the recognition by their plant hosts of two endosymbiotic microbes, arbuscular mycorrhizal (AM) fungi and nitrogen fixing rhizobia. The detailed analysis of the complexity and variability of the Ca2+ spiking patterns which have been revealed in recent studies requires both extensive datasets and sophisticated statistical tools. As a contribution, we have developed automated Ca2+ spiking analysis (CaSA) software that performs i) automated peak detection, ii) statistical analyses based on the detected peaks, iii) autocorrelation analysis of peak-to-peak intervals to highlight major traits in the spiking pattern.We have evaluated CaSA in two experimental studies. In the first, CaSA highlighted unpredicted differences in the spiking patterns induced in Medicago truncatula root epidermal cells by exudates of the AM fungus Gigaspora margarita as a function of the phosphate concentration in the growth medium of both host and fungus. In the second study we compared the spiking patterns triggered by either AM fungal or rhizobial symbiotic signals. CaSA revealed the existence of different patterns in signal periodicity, which are thought to contribute to the so-called Ca2+ signature. We therefore propose CaSA as a useful tool for characterizing oscillatory biological phenomena such as Ca2+ spiking.

  11. The comparison of assessment of pigeon semen motility and sperm concentration by conventional methods and the CASA system (HTM IVOS).

    Science.gov (United States)

    Klimowicz, M D; Nizanski, W; Batkowski, F; Savic, M A

    2008-07-01

    The aim of these experiments was to compare conventional, microscopic methods of evaluating pigeon sperm motility and concentration to those measured by computer-assisted sperm analysis (CASA system). Semen was collected twice a week from two groups of pigeons, each of 40 males (group I: meat-type breed; group II: fancy pigeon) using the lumbo-sacral and cloacal region massage method. Ejaculates collected in each group were diluted 1:100 in BPSE solution and divided into two equal samples. One sample was examined subjectively by microscope and the second one was analysed using CASA system. The sperm concentration was measured by CASA using the anti-collision (AC) system and fluorescent staining (IDENT). There were not any significant differences between the methods of evaluation of sperm concentration. High positive correlations in both groups were observed between the sperm concentration estimated by Thom counting chamber and AC (r=0.87 and r=0.91, respectively), and between the sperm concentration evaluated by Thom counting chamber and IDENT (r=0.85 and r=0.90, respectively). The mean values for CASA measurement of proportion of motile spermatozoa (MOT) and progressive movement (PMOT) were significantly lower than the values estimated subjectively in both groups of pigeons (pCASA system is very rapid, objective and sensitive method in detecting subtle motility characteristics as well as sperm concentration and is recommended for future research into pigeon semen.

  12. Manual vs. computer-assisted sperm analysis: can CASA replace manual assessment of human semen in clinical practice?

    Science.gov (United States)

    Talarczyk-Desole, Joanna; Berger, Anna; Taszarek-Hauke, Grażyna; Hauke, Jan; Pawelczyk, Leszek; Jedrzejczak, Piotr

    2017-01-01

    The aim of the study was to check the quality of computer-assisted sperm analysis (CASA) system in comparison to the reference manual method as well as standardization of the computer-assisted semen assessment. The study was conducted between January and June 2015 at the Andrology Laboratory of the Division of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, Poland. The study group consisted of 230 men who gave sperm samples for the first time in our center as part of an infertility investigation. The samples underwent manual and computer-assisted assessment of concentration, motility and morphology. A total of 184 samples were examined twice: manually, according to the 2010 WHO recommendations, and with CASA, using the program set-tings provided by the manufacturer. Additionally, 46 samples underwent two manual analyses and two computer-assisted analyses. The p-value of p CASA and manually. In the group of patients where all analyses with each method were performed twice on the same sample we found no significant differences between both assessments of the same probe, neither in the samples analyzed manually nor with CASA, although standard deviation was higher in the CASA group. Our results suggest that computer-assisted sperm analysis requires further improvement for a wider application in clinical practice.

  13. Electricity sector standard setting through CASA : a government perspective on multi-stakeholder partnerships

    International Nuclear Information System (INIS)

    Lakeman, B.

    2002-01-01

    Some background information is provided concerning new air emission standards for coal-fired generation in Alberta which were announced in June 2001 by the Environment Minister. An assessment of the situation has revealed that the existing management system is effective. The author questions whether it would be suitable to meet the challenges now emerging, such as multi-pollutant approaches, airshed approaches, cumulative effects, market-based approaches, and greenhouse gases. A Statement of Opportunity was tabled by the Alberta government with the Clean Air Strategic Alliance (CASA) board in November 2001, with the goals of outlining future emission management expectations, maintaining the competitive electricity market in Alberta, and a reduction of environmental impacts, among others. A CASA electricity project team was formed, whose stated objective was the development of an air emissions management approach to include standards and performance expectations for the electricity sector of Alberta. Stakeholders and the public were consulted for the purpose of establishing a common information base to be used in the identification of emissions to be addressed, the identification and assessment of management options and the recommendation of management approaches. The development of the terms of reference was accomplished through the establishment of a working group in January 2002. which were then approved in March 2002 by the CASA board. The budget and work plan were approved in June 2002, and an interim review is planned for November 2002 with the final report and recommendations expected in June 2003. The members of the team were listed, and some of the challenges are reviewed

  14. Arquitecturas reversibles de Japón. Las casas de Shirakawa-go

    Directory of Open Access Journals (Sweden)

    Paula Jaén Caparrós

    2017-04-01

    Full Text Available “Minka” significa literalmente “casas de la gente” en japonés, y se refiere a la casa tradicional japonesa construida fundamentalmente desde las épocas más antiguas hasta finales del siglo XIX. Se trata de construcciones sencillas y ligeras hechas habitualmente con elementos de madera, bambú, y paja, unidos por juntas de madera y cuerdas. Las regiones montañosas de Shirakawa-go y Gokayama, en la zona central de Japón, al Oeste de Tokio, permanecieron aisladas durante un largo periodo de tiempo. Como consecuencia de ello, allí se desarrolló un tipo específico de minka, las llamadas Gassho-zukuri, caracterizadas por el uso de un sistema extremadamente lógico y racional en su construcción resultado de una adaptación natural a las difíciles condiciones del entorno. Construidas como estructuras permanentes, estas casas tradicionales son sin embargo desmontables: sus distintos componentes permiten ser desarmados, recuperados y ensamblados de nuevo sin mayor dificultad. El alto potencial de desmontaje contenido en estas pequeñas construcciones invita a reflexionar acerca de las pautas proyectuales y constructivas presentes en sus soluciones que podrían ser recuperadas y aplicadas en propuestas actuales que integraran el desmontaje, la recuperación y el traslado de todo el objeto construido como factor clave para un diseño arquitectónico sostenible.

  15. About miRNAs, miRNA seeds, target genes and target pathways.

    Science.gov (United States)

    Kehl, Tim; Backes, Christina; Kern, Fabian; Fehlmann, Tobias; Ludwig, Nicole; Meese, Eckart; Lenhof, Hans-Peter; Keller, Andreas

    2017-12-05

    miRNAs are typically repressing gene expression by binding to the 3' UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of thoughts is: miRNAs with similar (seed) sequence target similar sets of genes and thus similar sets of pathways. By calculating similarity scores for all 3.25 million pairs of 2,550 human miRNAs, we found that this pattern frequently holds, while we also observed exceptions. Respective results were obtained for both, predicted target genes as well as experimentally validated targets. We note that miRNAs target gene set similarity follows a bimodal distribution, pointing at a set of 282 miRNAs that seems to target genes with very high specificity. Further, we discuss miRNAs with different (seed) sequences that nonetheless regulate similar gene sets or pathways. Most intriguingly, we found miRNA pairs that regulate different gene sets but similar pathways such as miR-6886-5p and miR-3529-5p. These are jointly targeting different parts of the MAPK signaling cascade. The main goal of this study is to provide a general overview on the results, to highlight a selection of relevant results on miRNAs, miRNA seeds, target genes and target pathways and to raise awareness for artifacts in respective comparisons. The full set of information that allows to infer detailed results on each miRNA has been included in miRPathDB, the miRNA target pathway database (https://mpd.bioinf.uni-sb.de).

  16. Retrospective study of penetrating keratoplasty at the Santa Casa of Porto Alegre

    OpenAIRE

    Fabris, Caroline; Corrêa, Zélia Maria S.; Marcon, Alexandre S.; Castro, Terla Nunes de; Marcon, Ítalo Mundialino; Pawlowski, Cristiane

    2001-01-01

    Objetivos: Traçar o perfil clínico e social dos pacientes submetidos a transplante de córnea e avaliar as principais indicações desses transplantes, tempo de espera para doação e os índices de sucesso, rejeição e falência dos transplantes penetrantes de córnea. Métodos: Foram analisados retrospectivamente os prontuários de 87 pacientes submetidos a transplante penetrante de córnea no Serviço de Oftalmologia da Santa Casa de Porto Alegre entre janeiro de 1990 e dezembro de 1998, totalizando 91...

  17. Projeto de extensão “lendo e escrevendo na casa lar”

    Directory of Open Access Journals (Sweden)

    Terezinha Corrêa Lindino

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/1807-0221.2013v10n16p1 O Projeto “Lendo e Escrevendo na Casa Lar”, edição 2012, teve como objetivo desenvolver atividades de leitura, escrita e alfabetização com crianças usuárias da Casa Lar da cidade de Marechal Cândido Rondon. Elaborado pela equipe pedagógica do Núcleo de Estudos e Defesa dos Direitos da Infância e da Juventude (NEDDIJ, em parceria com o Grupo de Estudo e Pesquisa em Formação de Professores (GEPEFOP, o Núcleo de Formação Docente e Prática de Ensino (NUFOPE e o Programa Institucional de Bolsa de Iniciação à Docência (PIBID, o projeto visou atender ao pedido do Conselho Municipal dos Direitos da Criança e do Adolescente (CMDCA do município de Marechal Cândido Rondon, de modo a minimizar as dificuldades pedagógicas apresentadas pelas crianças atendidas na Casa Lar dessa cidade. Para efetivar seu objetivo, as atividades que compuseram o projeto foram organizadas nas dependências da Casa Lar, conforme horário esquematizado pelos pais sociais, contando com a participação das coordenadoras e dos graduandos envolvidos. Em cada encontro, foram desenvolvidas oficinas sobre coordenação motora, ludicidade, leitura, escrita e aplicação de técnicas de Yoga, que visam auxiliar na aprendizagem e execução das atividades propostas. Para a realização dessas atividades, dividimos o grupo de participantes em três equipes, compostas por monitores dos cursos de Pedagogia, Letras, Geografia e Serviço Social. A cada período, por meio de reuniões entre os monitores e as coordenadoras do projeto, foi realizada uma verificação do andamento e progresso das crianças.

  18. A casa da cabeça de cavalo: a morte como lucidez

    Directory of Open Access Journals (Sweden)

    Maria Theresa Abelha Alves

    2003-03-01

    Full Text Available Oromance de Teolinda Gersão, A casa da cabeça de cavalo, mesclando variados modelos narrativos, tais como o romance de folhetim, a narrativa fantástica e a metaficção historiográfica, propõe uma nova perspectiva para os fatos e os conceitos consagrados pela lógica e adota, como estratégia desconstrutora, o lúdico e o humorístico, ao discursar sobre a morte e sobre a História. 

  19. Vascular Plant and Vertebrate Inventory of Casa Grande Ruins National Monument

    Science.gov (United States)

    Powell, Brian F.; Albrecht, Eric W.; Schmidt, Cecilia A.; Halvorson, William L.; Anning, Pamela; Docherty, Kathleen

    2006-01-01

    Executive Summary This report summarizes results of the first comprehensive biological inventory of Casa Grande Ruins National Monument (NM) in southern Arizona. Surveys at the monument were part of a larger effort to inventory vascular plants and vertebrates in eight National Park Service units in Arizona and New Mexico. In 2001 and 2002 we surveyed for vascular plants and vertebrates (amphibians, reptiles, birds, and mammals) at Casa Grande Ruins NM to document the presence, and in some cases relative abundance, of species. By using repeatable study designs and standardized field techniques, which included quantified survey effort, we produced inventories that can serve as the basis for a biological monitoring program. Of the National Park Service units in the region, no other has experienced as much recent ecological change as Casa Grande Ruins NM. Once situated in a large and biologically diverse mesquite bosque near the perennially flowing Gila River, the monument is now a patch of sparse desert vegetation surrounded by urban and commercial development that is rapidly replacing agriculture as the dominant land use in the area. Roads, highways, and canals surround the monument. Development, and its associated impacts, has important implications for the plants and animals that live in the monument. The plant species list is small and the distribution and number of non-native plants appears to be increasing. Terrestrial vertebrates are also being impacted by the changing landscape, which is increasing the isolation of these populations from nearby natural areas and thereby reducing the number of species at the monument. These observations are alarming and are based on our review of previous studies, our research in the monument, and our knowledge of the biogeography and ecology of the Sonoran Desert. Together, these data suggest that the monument has lost a significant portion of its historic complement of species and these changes will likely intensify as

  20. Itinerario de una arquitectura poética: las casas de Pablo Neruda

    Directory of Open Access Journals (Sweden)

    Majorie Agosín

    1992-12-01

    Full Text Available Con el advenimiento del gobiemo democrático de Patricio Alwyn en 1990, finaliza un legado de terror y despotismo de aproximadamente diecisiete años en Chile. La censura y Ia autocensura que tanto modificaron el espíritu creativo de la nación se encuentra lleno de energía y apertura y uno de los logros de mayor envergadura después de Ia derrota de Pinbchet consiste en las casas de Pablo Neruda, abiertas después de una clausum obligatoria par la dictadura militar.

  1. PROGRAMA “MINHA CASA, MINHA VIDA” COMO DIREITO FUNDAMENTAL SOCIAL À MORADIA

    OpenAIRE

    Silva, Juscelino Soares da; Silva, Jardel Pereira da

    2015-01-01

    O presente artigo objetiva analisar a moradia como direito fundamental social, ressaltando a necessidade de intervenção do Estado para a efetivação desse direito através da efetivação de políticas públicas, destacando o caso específico do programa social “Minha Casa, Minha Vida”. A pesquisa foi desenvolvida através de fonte documental e de instrumentos normativos, utilizando a doutrina e método dedutivo. Para maior compreensão do assunto abordado optou-se por dividir o trabalho em quatro part...

  2. The Political Agency of Victims in Atrocity Tales by Bartolomé de las Casas

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2016-01-01

    de las Casas, who is very often regarded as a precursor of modern human rights. I will argue that this atrocity tale is split between ethical universalism and international politics and that the image of the ‘victims’, that is, the American Indians, shifts like in a puzzle picture. The victims...... are both helpless, universalized bodies that are slaughtered by the Spanish, and in this way expose what Judith Butler has called a ‘primary vulnerability’ (Butler ) and they are potential political agents: inhabitants of defined political communities in the New World who have the right to protest against...... publication of this book in 1598....

  3. Don José Joquín Casas : un hombre una época

    Directory of Open Access Journals (Sweden)

    Rafael Azula Barrera

    1966-03-01

    Full Text Available Debo a las generosas instancias del reverendo padre Félix Restrepo -cuyo tránsito terrenal, concluído al finalizar el año último, se halla constelado de hazañas que reclaman ser esculpidas, como alto relieves, en el propio pedestal de la estatua que la gratitud nacional habrá de levantar a su nombre el honor inmerecido de pronunciar las palabras de rigor, al conmemorar nuestro instituto, en este día del idioma, el primer centenario del nacimiento de don José Joaquín Casas.

  4. Effect of semen preparation on casa motility results in cryopreserved bull spermatozoa.

    Science.gov (United States)

    Contri, Alberto; Valorz, Claudio; Faustini, Massimo; Wegher, Laura; Carluccio, Augusto

    2010-08-01

    Computer-assisted sperm analyzers (CASA) have become the standard tool for evaluating sperm motility and kinetic patterns because they provide objective data for thousands of sperm tracks. However, these devices are not ready-to-use and standardization of analytical practices is a fundamental requirement. In this study, we evaluated the effects of some settings, such as frame rate and frames per field, chamber and time of analysis, and samples preparations, including thawing temperature, sperm sample concentration, and media used for dilution, on the kinetic results of bovine frozen-thawed semen using a CASA. In Experiment 1, the frame rate (30-60 frame/s) significantly affected motility parameters, whereas the number of frames per field (30 or 45) did not seem to affect sperm kinetics. In Experiment 2, the thawing protocol affects sperm motility and kinetic parameters. Sperm sample concentration significantly limited the opportunity to perform the analysis and the kinetic results. A concentration of 100 and 50 x 10(6) sperm/mL limited the device's ability to perform the analysis or gave wrong results, whereas 5, 10, 20, and 30 x 10(6) sperm/mL concentrations allowed the analysis to be performed, but with different results (Experiment 3). The medium used for the dilution of the sample, which is fundamental for a correct sperm head detection, affects sperm motility results (Experiment 4). In this study, Makler and Leja chambers were used to perform the semen analysis with CASA devices. The chamber used significantly affected motility results (Experiment 5). The time between chamber loading and analysis affected sperm velocities, regardless of chamber used. Based on results recorded in this study, we propose that the CASA evaluation of motility of bovine frozen-thawed semen using Hamilton-Thorne IVOS 12.3 should be performed using a frame rate of 60 frame/s and 30 frames per field. Semen should be diluted at least at 20 x 10(6) sperm/mL using PBS. Furthermore, it is

  5. The effect of tracking network configuration on GPS baseline estimates for the CASA Uno experiment

    Science.gov (United States)

    Wolf, S. Kornreich; Dixon, T. H.; Freymueller, J. T.

    1990-01-01

    The effect of the tracking network on long (greater than 100 km) GPS baseline estimates was estimated using various subsets of the global tracking network initiated by the first Central and South America (CASA Uno) experiment. It was found that best results could be obtained with a global tacking network consisting of three U.S. stations, two sites in the southwestern Pacific, and two sites in Europe. In comparison with smaller subsets, this global network improved the baseline repeatability, the resolution of carrier phase cycle ambiguities, and formal errors of the orbit estimates.

  6. Garoto-propaganda Casas Bahia: configuração e estratégia

    OpenAIRE

    João, Aléxon Gabriel

    2015-01-01

    O fio condutor da análise dos anúncios é a construção discursiva, passando pelos princípios norteadores de Bakhtin que entende o texto como um suporte material que dialoga em diferentes níveis com o consumidor. Além do teórico russo, foram incorporados os conceitos de Eliseo Verón, Patrick Charaudeau e Paolo Fabbri. No caso do Garoto-propaganda Casas Bahia, a forma, o estilo e a maneira de anunciar os produtos da empresa parecem apontar para estratégias e movimentos muito peculiares que favor...

  7. El duelo es un trabajo

    OpenAIRE

    Mesa, Clara Cecilia

    2012-01-01

    Esta pregunta por lo nuevo en la atención en duelo invita a pensar en varias direcciones: qué hay de nuevo como oferta médica para ayudar a soportar la situación de pérdida que el duelo arrastra consigo, por un lado, pero por otro, qué hay de nuevo en el duelo? Es difícil saber si las condiciones de elaboración del duelo se modifican con las particularidades de una época o con las particularidades propias de cada modalidad de sufrimiento, igualmente existe una tesis que afirma que nuestra épo...

  8. El duelo es un trabajo

    Directory of Open Access Journals (Sweden)

    Clara Cecilia Mesa

    2001-02-01

    Full Text Available Esta pregunta por lo nuevo en la atención en duelo invita a pensar en varias direcciones: qué hay de nuevo como oferta médica para ayudar a soportar la situación de pérdida que el duelo arrastra consigo, por un lado, pero por otro, qué hay de nuevo en el duelo? Es difícil saber si las condiciones de elaboración del duelo se modifican con las particularidades de una época o con las particularidades propias de cada modalidad de sufrimiento, igualmente existe una tesis que afirma que nuestra época no es ya la época de la muerte romántica más bien que la condición de guerra haría a su vez que las
    coordenadas del duelo podrían pensarse de manera distinta, sin embargo detrás de lo nuevo siempre encontramos lo viejo: la muerte. Parafraseando el último verso de “Las Flores del Mal” de Baudelaire:

  9. Natural(es) remisión de V. ciencias natural(es).

    OpenAIRE

    2011-01-01

    [ES] Definición del término Natural(es) remisión de V. ciencias natural(es). en el diccionario Dicter. [EN] Definition of the word Natural(es) remisión de V. ciencias natural(es). in the dictionary Dicter.

  10. Implementing an open-access CASA software for the assessment of stallion sperm motility: Relationship with other sperm quality parameters.

    Science.gov (United States)

    Giaretta, Elisa; Munerato, Mauro; Yeste, Marc; Galeati, Giovanna; Spinaci, Marcella; Tamanini, Carlo; Mari, Gaetano; Bucci, Diego

    2017-01-01

    Setting an open-access computer assisted sperm analysis (CASA) may benefit the evaluation of motility in mammalian sperm, especially when economic constraints do not allow the use of a commercial system. There have been successful attempts to develop such a device in Zebra fish sperm and the system has been used in very few studies on mammalian spermatozoa. Against this background, the present study aimed at developing an open-access CASA system for mammalian sperm using the horse as a model and based upon the Image J software previously established for Zebra fish sperm. Along with determining the sperm progressive motility and other kinetic parameters (such as amplitude of lateral head displacement), the "results" window was adjusted to simplify subsequent statistical analyses. The path window was enriched with colored sperm trajectories on the basis of the subpopulation they belong to and a number that allowed the sperm track to be associated to the sperm motility data shown in the "results" window. Data obtained from the novel plugin (named as CASA_bgm) were compared with those of the commercial CASA Hamilton-Thorn IVOS Vers.12, through Bland Altman's plots. While the percentage of total and progressive motile sperm, VCL, VAP, VSL, LIN and STR and ALH were in agreement with those obtained with the commercial system, BCF significantly differed between the two systems probably due to their settings. Interestingly, a positive and significant correlation between the percentages of total motile sperm evaluated through CASA_bgm and those showing high mitochondrial membrane potential evaluated by JC-1 staining was found. In conclusion, CASA_bgm ImageJ plugin could be useful and reliable for stallion sperm motility analysis and it is our aim to apply this system to other mammalian species. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. “Santa Eulalia. Memorias de una Casa Abierta”. (Biografía de Enrique Uribe White

    Directory of Open Access Journals (Sweden)

    Mario Camacho Pinto

    2000-12-01

    Full Text Available

    Desde el comienzo hasta el final de la lectura de este libro, resulta emocionante configurar la reseña sobre su contenido que se refiere a la inusual trayectoria allí descrita de “La Casa de la Tertulia” como la denominó el ex Presidente Belisario Betancur en el inicio del Prólogo, en el que más adelante elogia la forma como “su autor, el médico humanista Efraím Otero- Ruiz, describe su hermoso libro”.

    El autor del libro en su Introducción la denomina “Casa Abierta”, puesto que como lo relata escuetamente, así se mantenía los fines de semana y días festivos, una verdadera “open house” en donde visitantes y amigos podían entrar y salir libremente, todo lo cual es reconstruido con gran fidelidad, en sus propias palabras.

    Enrique Uribe White, hijo de médico y sobrino nada menos que del general Rafael Uribe Uribe, es presentado como descendiente de una racha de antioqueños notables que se lanzaron a colonizar las tierras de Caldas y del Norte del Valle del Cauca, fundando de paso pueblos importantes como Sevilla y Caicedonia. Anota en forma detallada cómo por línea paterna y materna fluyeron los genes que harían de Enrique un intelectual.

    Es admirable el trabajo de investigación, descripción ordenada y detallada sobre la privilegiada vida del personaje que motiva este libro, sobre su formación, educación, instrucción dentro y fuera del país; su inquietud intelectual, su afición por la música, hasta su traslado a Bogotá en plena madurez, que muestra con la fundación de la Revista PAN y el Club Náutico del Muña, y más tarde como Director de la Biblioteca Nacional. Veamos algunos detalles:

    “En su vivienda por el camino hacia Suba le echa el ojo a un lote de la Hacienda Viscaya y lo compra” y construye su exótica mansión que bautizó “Santa Eulalia” en memoria del sitio de donde son originarios sus antepasados viscainos y vascos (Santa Eulalia de Borgoña. “El dise

  12. La restauración de la Casa Yamamura de Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Hidekazu Nishizawa

    2004-12-01

    Full Text Available La Casa Yamamura, proyectada por el arquitecto en 1918 para un solar ubicado en Ashiya (Hyogo, se aleja en su diseño del resto de su obra japonesa para acercarse a las características de su etapa californiana. Su singularidad se reflejó en su declaración como Bien de Interés Cultural en 1974, como primer edificio de la era Taisho (1912-1926 que recibía tal distinción. A principios de los años ochenta, la casa, en estado de desidia, fue objeto de estudio y restauración. Posteriormente, el terremoto de Kobe de 1995 afectó seriamente al edificio, de manera que se debió emprender una nueva restauración que constituye el contenido principal de este artículo.

  13. Paradigm, experiment and conclusion: La Casa by Bernard Rudofsky in three acts

    Directory of Open Access Journals (Sweden)

    Héctor García-Diego Villarías

    2018-04-01

    Full Text Available La Casa –or in English, the house– that Bernard Rudofsky built on the Spanish Mediterranean coast in 1971 is a valuable case study on the operational possibilities of popular architecture in the practice of this contemporary discipline. It is a repository of theoretical references typical of the vernacular world; its author, known for the exhibition Architecture without Architects, is emblematic of this type of architecture to which he dedicated much of his efforts as a theorist and polemicist throughout the course of his life. Additionally, La Casa is a unique architectural feat as it involves the practical materialization of its implicated theoretical position. It is possible that a concrete conclusion can be drawn from this case, which may shed light on the possible operability of a type of architecture that presents more than a few difficulties for the current context of the discipline, despite being habitually admired and praised. Additionally, the text presented here brings to light unpublished information found in the personal diaries of the architect that allows for the recreation of the circumstances surrounding the ideation and construction of this piece of architecture.

  14. Documenting Modern Mexican Architectural Heritage for Posterity: Barragan's Casa Cristo, in Guadalajara, Mexico

    Science.gov (United States)

    Mezzino, D.; Pei, W.; Santana Quintero, M.; Reyes Rodriguez, R.

    2015-08-01

    This contribution describes the results of an International workshop on documentation of historic and cultural heritage developed jointly between Universidad de Guadalajara's Centro Universitario de Arte, Arquitectura y Diseño (CUAAD) and Carleton University's Architectural Conservation and Sustainability Program. The objective of the workshop was to create a learning environment for emerging heritage professionals through the use of advanced recording techniques for the documentation of modern architectural heritage in Guadalajara, Mexico. The selected site was Casa Cristo, one of the several architectural projects by Luis Barragán in Guadalajara. The house was built between 1927 and 1929 for Gustavo R. Cristo, mayor of the city. The style of the building reflects the European influences derived from the architect's travel experience, as well as the close connection with local craftsmanship. All of these make the house an outstanding example of modern regional architecture. A systematic documentation strategy was developed for the site, using different survey equipment and techniques to capture the shape, colour, spatial configuration, and current conditions of Casa Cristo for its eventual rehabilitation and conservation.

  15. Dilemas de autenticidad: la restauración de la Casa Freeman de Frank Lloyd Wright

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Chusid

    2015-06-01

    Full Text Available El artículo expone una breve descripción histórica ilustrativa del proceso de encargo, diseño y construcción de la casa con los bloques prefabricados característicos de la etapa californiana de Wright y de la vida posterior del edificio, centro neurálgico de la actividad de vanguardia artística de Los Ángeles, con sustanciales modificaciones llevadas a cabo por otros arquitectos afamados como Rudolph Schindler, Gregory Ain and John Lautner. En el texto se refleja no solo la tremenda complejidad técnica de restaurar esta casa erigida con un sistema constructivo sugerente pero tremendamente frágil y problemático y la dificultad añadida de su presencia en zona sísmica y los daños sufridos por el terremoto de Los Ángeles de 1994, sino también el dilema que surge a la hora de escoger eventualmente qué fase restaurar del edificio entre toda la estratificación de intervenciones de arquitectos estrella que caracteriza a este edificio.

  16. Organizaçao e funcionamento duma casa de abrigo de solidariedade social

    Directory of Open Access Journals (Sweden)

    Maria Jose Magalhaes

    2011-12-01

    Full Text Available A organização e o funcionamento de uma casa de abrigo de uma instituição humanista não feminista (chamada de "Solidariedade Social" constituiu o foco central desta pesquisa. Para isto, realizaram-se entrevistas semi-estruturadas às profissionais: à diretora da instituição, à diretora técnica e ao psicólogo. A análise apresenta uma visão de uma casa de abrigo normativa sobre o que deve ser uma mulher, incluindo as suas rotinas diárias, associada a uma organização rígida no que diz respeito a regras e horários. Mais ainda, perspectivando a mulher apenas como mãe e doméstica, esta perspectiva apresenta uma elevada tolerância à violência de gênero. A este respeito, este tipo de instituições corre sério risco de cair na perspectiva de "revitimizar" a vítima.

  17. Território, desigualde e cidadania: o Programa Minha Casa, Minha Vida em Londrina

    Directory of Open Access Journals (Sweden)

    Eliane Barbosa Santos Pagani

    2013-12-01

    Full Text Available Este artigo tem como escopo tecer algumas reflexões sobre a relevância da perspectiva territorial para a gestão das políticas habitacionais. A Política Nacional de Habitação (2004 considera o direito à moradia para além de uma casa para morar, ou seja, este direito se concretiza quando o cidadão acessa também outros bens e serviços, permitindo o acesso à cidade em sua totalidade. Isto implica a moradia como direito de inclusão social, garantindo padrão mínimo de habitabilidade, infraestrutura, saneamento, mobilidade, transporte coletivo, equipamentos, serviços urbanos e sociais. Entendendo que são nos vários territórios da cidade que este direito se concretiza, em maior ou em menor proporção, busca compreender como foi considerado esta categoria analítica, cuja literatura considera como central para uma estratégia efetiva de inclusão social, em um empreendimento habitacional do Programa Minha Casa, Minha Vida no município de Londrina.

  18. Effects of diluting medium and holding time on sperm motility analysis by CASA in ram

    Directory of Open Access Journals (Sweden)

    Somayeh Mostafapor

    2014-06-01

    Full Text Available The aim of this study was to evaluate the effects of dilution rate and holding time on various motility parameters using computer-assisted sperm analysis (CASA. The semen samples were collected from three Ghezel rams. Samples were diluted in seminal plasma (SP, phosphate-buffered saline (PBS containing 1% bovine serum albumin (BSA and Bioexcell. The motility parameters that computed and recorded by CASA include curvilinear velocity (VCL, straight line velocity (VSL, average path velocity (VAP, straightness (STR, linearity (LIN, amplitude of lateral head displacement (ALH, and beat cross frequency (BCF. In all diluters, there was a decrease in the average of all three parameters of sperms movement velocity as the time passed, but density of this decrease was more intensive in SP. The average of ALH between diluters indicated a significant difference, as it was more in Bioexcell in comparison with the similar amount in SP and PBS. The average of LIN in the diluted sperms in Bioexcell was less than two other diluters in all three times. The motility parameters of the diluted sperms in Bioexcell and PBS indicated an important and considerable difference with the diluted sperms in SP. According to the gained results, the Bioexcell has greater ability in preserving motility of sperm in comparison with the other diluters but as SP is considered as physiological environment for sperm. It seems that the evaluation of the motility parameters in Bioexcell and PBS cannot be an accurate and comparable evaluation with SP.

  19. Casa comercial Uribe Ruiz Hermanos 1894 – 1916. El caso de una empresa familiar en Antioquia

    Directory of Open Access Journals (Sweden)

    Ana María Mesa Bedoya

    2011-01-01

    Full Text Available En el texto se describe el funcionamiento de la casa comercial Uribe Ruiz Hermanos que operó en Rionegro, Medellín y Manizales, localidades antioqueñas, desde 1894 hasta 1916. En Colombia desde medidos de siglo XIX las oportunidades para incrementar el comercio de exportación de materias primas e importación de manufacturas aumentaron. Antioquia fue una de las regiones más dinámicas del país en cuanto al desarrollo de relaciones comerciales e integración de mercados locales con centros urbanos gracias al comercio. Pedro y Estanislao Uribe Ruiz, fundadores de Uribe Ruiz Hermanos, organizaron su casa de comercio a través de la red parental con lo que aseguraron la continuidad del negocio y la confianza para invertir en diversos campos económicos, como era costumbre entre otros comerciantes antioqueños durante el siglo XIX. La principal fuente de consulta fue el archivo José María Uribe Uribe 1838-1921 en el que se encuentra información de las firmas comerciales José María Uribe e Hijos y Uribe Ruiz Hermanos.

  20. Implementation of novel statistical procedures and other advanced approaches to improve analysis of CASA data.

    Science.gov (United States)

    Ramón, M; Martínez-Pastor, F

    2018-04-23

    Computer-aided sperm analysis (CASA) produces a wealth of data that is frequently ignored. The use of multiparametric statistical methods can help explore these datasets, unveiling the subpopulation structure of sperm samples. In this review we analyse the significance of the internal heterogeneity of sperm samples and its relevance. We also provide a brief description of the statistical tools used for extracting sperm subpopulations from the datasets, namely unsupervised clustering (with non-hierarchical, hierarchical and two-step methods) and the most advanced supervised methods, based on machine learning. The former method has allowed exploration of subpopulation patterns in many species, whereas the latter offering further possibilities, especially considering functional studies and the practical use of subpopulation analysis. We also consider novel approaches, such as the use of geometric morphometrics or imaging flow cytometry. Finally, although the data provided by CASA systems provides valuable information on sperm samples by applying clustering analyses, there are several caveats. Protocols for capturing and analysing motility or morphometry should be standardised and adapted to each experiment, and the algorithms should be open in order to allow comparison of results between laboratories. Moreover, we must be aware of new technology that could change the paradigm for studying sperm motility and morphology.

  1. CASA-Mot technology: how results are affected by the frame rate and counting chamber.

    Science.gov (United States)

    Bompart, Daznia; García-Molina, Almudena; Valverde, Anthony; Caldeira, Carina; Yániz, Jesús; Núñez de Murga, Manuel; Soler, Carles

    2018-04-04

    For over 30 years, CASA-Mot technology has been used for kinematic analysis of sperm motility in different mammalian species, but insufficient attention has been paid to the technical limitations of commercial computer-aided sperm analysis (CASA) systems. Counting chamber type and frame rate are two of the most important aspects to be taken into account. Counting chambers can be disposable or reusable, with different depths. In human semen analysis, reusable chambers with a depth of 10µm are the most frequently used, whereas for most farm animal species it is more common to use disposable chambers with a depth of 20µm . The frame rate was previously limited by the hardware, although changes in the number of images collected could lead to significant variations in some kinematic parameters, mainly in curvilinear velocity (VCL). A frame rate of 60 frames s-1 is widely considered to be the minimum necessary for satisfactory results. However, the frame rate is species specific and must be defined in each experimental condition. In conclusion, we show that the optimal combination of frame rate and counting chamber type and depth should be defined for each species and experimental condition in order to obtain reliable results.

  2. Effects of diluting medium and holding time on sperm motility analysis by CASA in ram.

    Science.gov (United States)

    Mostafapor, Somayeh; Farrokhi Ardebili, Farhad

    2014-01-01

    The aim of this study was to evaluate the effects of dilution rate and holding time on various motility parameters using computer-assisted sperm analysis (CASA). The semen samples were collected from three Ghezel rams. Samples were diluted in seminal plasma (SP), phosphate-buffered saline (PBS) containing 1% bovine serum albumin (BSA) and Bioexcell. The motility parameters that computed and recorded by CASA include curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP), straightness (STR), linearity (LIN), amplitude of lateral head displacement (ALH), and beat cross frequency (BCF). In all diluters, there was a decrease in the average of all three parameters of sperms movement velocity as the time passed, but density of this decrease was more intensive in SP. The average of ALH between diluters indicated a significant difference, as it was more in Bioexcell in comparison with the similar amount in SP and PBS. The average of LIN in the diluted sperms in Bioexcell was less than two other diluters in all three times. The motility parameters of the diluted sperms in Bioexcell and PBS indicated an important and considerable difference with the diluted sperms in SP. According to the gained results, the Bioexcell has greater ability in preserving motility of sperm in comparison with the other diluters but as SP is considered as physiological environment for sperm. It seems that the evaluation of the motility parameters in Bioexcell and PBS cannot be an accurate and comparable evaluation with SP.

  3. Cuando dejan de ser bebés. Una experiencia en la casa infantil Universitaria

    Directory of Open Access Journals (Sweden)

    Karla Martorell Esquivel

    2007-01-01

    Full Text Available En el presente artículo se realiza un análisis reflexivo acerca de los procesos experimentados por los niños y las niñas entre los dos y los tres años, en relación con los cambios continuos y progresivos en las diferentes áreas del desarrollo, a saber socioafectiva, cognitivo-lingüístico y psicomotriz. Asimismo, se da a conocer la experiencia obtenida como docentes de la Casa Infantil Universitaria de la Universidad de Costa Rica en cuanto a las generalidades del desarrollo en esta edad. Las particularidades presentadas por la población infantil que asiste a la institución, así como las estrategias seguidas para su atención. Se hace referencia a la experiencia lograda durante el período del II Ciclo 2005 y el I Ciclo 2006, el cual constituyó una excelente oportunidad para favorecer el desarrollo integral de las personas de esas edades y el crecimiento profesional y personal de las maestras de la Casa Infantil Universitaria. Finalmente, se brindan algunas estrategias y consideraciones finales sobre cómo conducir y guiar a los niños y las niñas de esta edad en ambientes no escolarizados.

  4. Historia del Hogar Casa Cuna de la ciudad de Mendoza: La institución que permanece

    OpenAIRE

    Farias Carracedo, Ana Carolina

    2017-01-01

    Este trabajo presenta la historia del Hogar Casa Cuna en la ciudad de Mendoza, Argentina,desde sus orígenes, a principios del siglo XX, hasta la actualidad enmarcando dicha historia enel contexto legislativo nacional y provincial.En sus orígenes, la Casa Cuna fue fundada por las Damas de la Caridad. En 1950 el Estado, pormedio de la Dirección Provincial del Menor, se hizo cargo de dicha institución aunque delegó elcuidado de los niños a las Hermanas de Nuestra Señora del Rosario que desempeña...

  5. Gestión y organización de Casa Guatemala. Requisitos funcionales de un CRM

    OpenAIRE

    Gil de Avalle Muñoz, Maria

    2011-01-01

    Detección de los problemas actuales importantes de Casa Guatemala que impiden tener una buena organización y que, junto a la crisis económica mundial que se vive, impiden su resolución. · Diseño de una nueva organización estructurada y una nueva manera de gestionar Casa Guatemala que aporte beneficios, solucione su crisis interna y ayude a la falta de recursos económicos que se obtienen actualmente. · Descripción de nuevos canales de comunicación entre diferentes agentes de ...

  6. Development and Validation of the Coping with Acculturative Stress in American Schools (Casas-A) Scale on a Latino Adolescent Sample

    Science.gov (United States)

    Castro-Olivo, Sara M.; Palardy, Gregory J.; Albeg, Loren; Williamson, Ariel A.

    2014-01-01

    The psychometric properties of the Coping With Acculturative Stress in American Schools (CASAS-A) scale were examined using a sample of 148 Latino middle school students. CASAS-A is a self-report scale designed to identify students in need of culturally responsive social-emotional interventions due to having high levels of school-related…

  7. Diagnostic potential of miR-126, miR-143, miR-145, and miR-652 in malignant pleural mesothelioma

    DEFF Research Database (Denmark)

    Andersen, Morten; Grauslund, Morten; Ravn, Jesper

    2014-01-01

    Malignant pleural mesothelioma (MPM) is difficult to distinguish from reactive mesothelial proliferations (RMPs). It is uncertain whether miRNAs are useful biomarkers for differentiating MPM from RMPs. Thus, we screened with a quantitative RT-PCR (RT-qPCR)-based platform the expression of 742 miR...

  8. Taking a multiple intelligences (MI) perspective.

    Science.gov (United States)

    Gardner, Howard

    2017-01-01

    The theory of multiple intelligences (MI) seeks to describe and encompass the range of human cognitive capacities. In challenging the concept of general intelligence, we can apply an MI perspective that may provide a more useful approach to cognitive differences within and across species.

  9. Miércoles al cine

    OpenAIRE

    Aguado Franco, Juan Carlos

    2014-01-01

    Se analiza un caso concreto de demanda ante una iniciativa empresarial: los miércoles al cine. Se analiza un caso concreto de demanda ante una iniciativa empresarial: los miércoles al cine. Fundamentos del Análisis Económico

  10. La Casa Natal de Carlos J. Finlay. Un monumento del siglo XVIII Carlos Juan Finlay´s home: a XVII century monument

    Directory of Open Access Journals (Sweden)

    Gisela Gil Turnes

    2006-08-01

    Full Text Available En el siglo XVIII se realizan en la ciudad de Camagüey grandes obras arquitectónicas, sobresaliendo entre ellas las de tipo religioso y doméstico; y de estas últimas la casa marcada con el número 4, actual 5 de la calle Cristo es una de sus muestras relevantes. En ella vio la luz una de las figuras más sobresaliente de la medicina mundial, el doctor Carlos J. Finlay Barrés. El trabajo trata de los valores históricos y arquitectónicos del inmueble. El primero representado por el nacimiento del eminente científico; y el segundo por ser fiel exponente de las codificaciones en la vivienda colonial de la arquitectura camagüeyana en dicha etapaDuring the XVIII century big architectural Works carried out, standing out tose of religious and domestic types, and, among the last ones, the house marked with number 4, on Cristo Street is an outstanding sample. There, one the most relevant figures of the world medicine: Doctor Carlos J. Finlay Barrés, was born. This work is about the historical and architectural values of this property. The first one represented by the birth of the eminent scientist, and the second, for being a faithful exponent of the codes in the colonial housing of Camague y ´ s architecture in this stage

  11. Cavernomas: conduta no serviço de neurocirurgia da Santa Casa de Belo Horizonte Cavernous malformations: surgical management in Belo Horizonte Santa Casa Hospital

    Directory of Open Access Journals (Sweden)

    Marcello Penholate Faria

    2004-12-01

    Full Text Available A melhor compreensão da história natural dos cavernomas, o aprimoramento dos métodos diagnósticos e das técnicas microcirúrgicas tornaram possíveis as seguintes condutas: tratamento conservador, radiocirurgia e ressecção cirúrgica. Apresenta-se revisão de 33 pacientes operados no serviço de Neurocirurgia da Santa Casa de Belo Horizonte, no período de 1992 a 2001. Cavernomas corticais e subcorticais que se manifestaram por crises convulsivas de difícil controle (57,5% ou principalmente por hemorragia (15,1% foram tratados cirurgicamente. As lesões profundas (gânglios basais, tálamo e tronco encefálico somaram 27,7%. Estas, atualmente, só devem ser operadas quando estão próximas à superfície ependimária ou pial. Indicou-se ainda a ressecção de lesões medulares (5,5% e cerebrais profundas, que apresentaram déficit focal progressivo(13,8% ou episódios recorrentes de hemorragia(13,8%. As lesões pequenas e profundas que não apresentam hemorragia devem ser tratadas conservadoramente.Não existe, no momento, evidência de resultados favoráveis com a radiocirurgia.The better understanding of the natural history of the cavernous malformations and the improvement of diagnostic methods and of microsurgical techniques have made the management of cavernous malformations possible through the conservative treatment, radiosurgery, and microsurgical resection. We present 33 cases operated at our service at Santa Casa Hospital, Belo Horizonte, from 1992 to 2001. Cortical and subcortical cavernomas manifested by epilepsy (57.5% or mainly by hemorrhage (15.1% were surgically approached. The deep lesions (basal ganglia, talamo and brain steam represented 27.7% of our cases. They should only be operated when located near the pial or ependimary surface. The resection of spinal cord lesions (5.5% and of deep brain lesions is also recommended when they present progressive focal deficit (13.8% or recurrent episodes of hemorrhage (13

  12. La gráfica política y los marcos de acción colectiva en San Cristóbal de Las Casas, Chiapas (2010-2013

    Directory of Open Access Journals (Sweden)

    Carlos de Jesùs Gómez Abarca

    2018-01-01

    Full Text Available El objetivo de este artículo es interpretar la gráfica política realizada en San Cristóbal de Las Casas, Chiapas, integrada por composiciones que generalmente incluyen texto e imágenes. Se realizó, inicialmente, un análisis elemental de tipo semiótico visual a un registro fotográfico (2010-2013 de 63 producciones visuales, el cual fue complementado, posteriormente, con una interpretación desde la perspectiva de los marcos de acción colectiva. Se concluye que estas intervenciones, además de ser un vehículo de expresión política, constituyen marcos interpretativos que orientan las acciones colectivas de los diferentes actores políticos que confluyen en la ciudad.

  13. In Situ Vitrification Engineering-Scale Test ES-INEL-4, ES-INEL-5, ES-INEL-6, and ES-INEL-7 Test Plan

    International Nuclear Information System (INIS)

    Weidner, J.R.; Stoots, P.R.

    1990-10-01

    The In Situ Vitrification Engineering-Scale Tests ES-4, ES-5, ES-6, and ES-7 Product Characterization Test Plan describes the methods and procedures to be used or the physical and chemical characterization of the solid product(s) resulting from the Idaho National Engineering Laboratory engineering scale in situ vitrification tests ES-4, ES-5, ES-6, and ES-7. The goals of this Test Plan are to insure that the product characterization results are sufficient to meet the data needs of the In Situ Vitrification Program and are technically and legally defensible. Important issues addressed by the test plan include sampling and analysis strategy, sampling procedures, laboratory analysis, sample control and document management, equipment, data reporting and validation, quality assurance, specific routine procedures to assess data representativeness, safety and training program, and data management. 9 refs., 1 fig., 3 tabs

  14. Religions mondialisées.

    Directory of Open Access Journals (Sweden)

    Sébastien Fath

    2002-05-01

    Full Text Available « Dès le début de l’histoire, les croyances religieuses manifestent une tendance à ne pas se renfermer dans une société politique étroitement délimitée : il y a en elles comme une aptitude naturelle à passer par-dessus les frontières, à se diffuser, à s’internationaliser ». Ces réflexions d’Émile Durkheim, extraites des Formes élémentaires de la vie religieuse , sont placées en exergue de l’ouvrage d’Ariel Colonomos consacré aux « Églises en réseau ». ...

  15. miRNAFold: a web server for fast miRNA precursor prediction in genomes.

    Science.gov (United States)

    Tav, Christophe; Tempel, Sébastien; Poligny, Laurent; Tahi, Fariza

    2016-07-08

    Computational methods are required for prediction of non-coding RNAs (ncRNAs), which are involved in many biological processes, especially at post-transcriptional level. Among these ncRNAs, miRNAs have been largely studied and biologists need efficient and fast tools for their identification. In particular, ab initio methods are usually required when predicting novel miRNAs. Here we present a web server dedicated for miRNA precursors identification at a large scale in genomes. It is based on an algorithm called miRNAFold that allows predicting miRNA hairpin structures quickly with high sensitivity. miRNAFold is implemented as a web server with an intuitive and user-friendly interface, as well as a standalone version. The web server is freely available at: http://EvryRNA.ibisc.univ-evry.fr/miRNAFold. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  16. stockées Ephestia kuehniella (Lepidoptera)

    African Journals Online (AJOL)

    PR BOKO

    de Rebat (2008). [5] - B. DOUMANDJI-MITICHI. Etude d'un ravageur des denrées stockées E. Kuehiella, Am.El Harrach. (1997). [6] - F. TAIBI. Etude comparée du développement et de la reproduction chez deux ravageurs des denrées stockées Ephestia Kuehniella et Tenebrio molitor. Aspect endocrinien en rapport avec.

  17. Mi oíslo

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2006-12-01

    Full Text Available Hablando Sancho en su primer encuentro con don Quijote de su mujer Juana Gutiérrez, llamada en seguida Teresa Panza o simplemente Teresa, la nombra mi oíslo y repite lo mismo otras dos veces. Conviene tener presente que de su mujer Sancho habla siempre respetuosamente y con mucho cariño, con excepción de una conversación que llega a ser un litigio, II, 5. Allí, Sancho expresa su idea de cómo y con quién casar a la hija Sanchica y por fin impone su voluntad. Teresa se le opone vigorosamente y esto induce a Sancho, sobreexcitado, a formular una gradación sorprendente: mujer mía; mirad, Teresa; mujer; calla, boba; bestia y mujer de Barrabás; animalia; mentecata e ignorante.

  18. LA UNIÓN EN EMPRESAS FAMILIARES RESTAURANTERAS: UNA APROXIMACIÓN A LA SUCESIÓN GENERACIONAL EN EMPRESAS CON ACTIVIDAD TURÍSTICA DE SAN CRISTÓBAL DE LAS CASAS

    Directory of Open Access Journals (Sweden)

    Carlos Jesús González-Macías

    2016-06-01

    Full Text Available La sucesión generacional en una empresa es un proceso dinámico en que los papeles y tareas del predecesor y del sucesor evolucionan de manera independiente y en paralelo, hasta que se cruzan y se superponen, encaminando la empresa a la sustentabilidad. El presente documento reflexiona sobre la relación entre sucesión generacional y sustentabilidad en dichas empresas, analizando una muestra de conveniencia de nueve empresas familiares restauranteras en San Cristóbal de las Casas (Chiapas, México, y realizando un comparativo cualitativo a partir de los indicadores de las variables de estudio. Adicionalmente, se examina la situación de las empresas familiares en México y su relevancia e importancia para la economía. Se encontró que la importancia de la empresa familiar, tanto a nivel nacional como local, y el amplio desarrollo de la actividad restaurantera en San Cristóbal de las Casas, motivan a las familias dedicadas a esta actividad a continuar sus negocios y a transmitirlos a las futuras generaciones para ser sustentables, ya que, de acuerdo con lo que reporta el Instituto Nacional de Estadística y Geografía (INEGI, nueve de diez empresas familiares que se crean no llegan a los dos años de vida, lo cual constituye un índice de mortalidad extremo.         La unión familiar al interior de la empresa es el vínculo ideal para la sustentabilidad de la misma, ya que de ella depende una exitosa sucesión generacional que propicie que la empresa familiar perdure en sus actividades.

  19. Diversity of amphibians and reptiles associated with grasslands of Janos-Casas Grandes, Chihuahua, Mexico (La diversidad de anfibios y reptiles asociada a los pastizales de Janos-Casas Grandes, Chihuahua, Mexico)

    Science.gov (United States)

    Georgina Santos-Barrera; Jesus Pacheco-Rodriguez

    2006-01-01

    Prairie-dog (Cynomys ludovicianus) colonies in northwest Chihuahua, Mexico, have been of great significance not only in initiating protection programs for the species but also in learning about the biological diversity (flora and fauna) of the natural grasslands of Janos-Casas Grandes, Chihuahua. Therefore a study of the herpetological fauna within the prairie-dog...

  20. Altering β-cell number through stable alteration of miR-21 and miR-34a expression

    DEFF Research Database (Denmark)

    Backe, Marie Balslev; Novotny, Guy Wayne; Christensen, Dan Ploug

    2014-01-01

    RNAs, miR-21 and miR-34a, may be involved in mediating cytokine-induced β-cell dysfunction. Therefore, manipulation of miR-21 and miR-34a levels may potentially be beneficial to β cells. To study the effect of long-term alterations of miR-21 or miR-34a levels upon net β-cell number, we stably overexpressed...

  1. Pasiones políticas e imperialismo : la polémica entre Ginés de Sepúlveda y Bartolomé de las Casas

    Directory of Open Access Journals (Sweden)

    Sandra Chaparro

    2001-01-01

    Full Text Available Durante siglos el «amor» se ha venido considerando una virtud política, sostenedora de la vida comunitaria y fuente de la solidaridad social. Como tal, se trata de una pasión que se encuentra en la base de los sistemas simbólicos del pensamiento político occidental, si bien hoy, pasiones y política parecen dos conceptos alejados entre sí No obstante, en un mundo en vías de globalización resurgen con fuerza términos como solidaridad o cooperación, conceptos que implican una buena dosis de «amor político». El objeto de este trabajo es recurrir al ejemplo histórico como una buena manera de señalar los riesgos y limitaciones de esta estrategia. Así, en él se analizan los debates suscitados en el siglo xvi en torno a la forma correcta de cristianizar a las sociedades indígenas americanas a través de la polémica entre el «universalismo benevolente» de Bartolomé de las Casas y la idea de «cruzada como acto de amor» de Ginés de Sepúlveda. Esta polémica histórica resulta ser un magnifico ejemplo de la disputa en torno a la correcta utilización de las «pasiones políticas».For centuries, «love» as been a political virtue enhancing communitarism and social solidarity. As such, it as been a passion we find in the basis of the symbolic systems of wesern political thought, though nowadays passions and politics seem to be different realities. Nevertheless, in a worid in which globalization process take place, concepts based on «political love» like solidarity or cooperation recover their original force. The aim of this study is to appeal to an historical example to show the risks and limits of certain kinds of globalization strategies. This article is about the debates that took place in the sixteenth century, when jurists and theologians had to decide which was the right way of christianizing american natives. The historical debate between Bartolomé dse las Casas and his concept of «benevolent universalism» and Gines

  2. MiMiR: a comprehensive solution for storage, annotation and exchange of microarray data

    Directory of Open Access Journals (Sweden)

    Rahman Fatimah

    2005-11-01

    Full Text Available Abstract Background The generation of large amounts of microarray data presents challenges for data collection, annotation, exchange and analysis. Although there are now widely accepted formats, minimum standards for data content and ontologies for microarray data, only a few groups are using them together to build and populate large-scale databases. Structured environments for data management are crucial for making full use of these data. Description The MiMiR database provides a comprehensive infrastructure for microarray data annotation, storage and exchange and is based on the MAGE format. MiMiR is MIAME-supportive, customised for use with data generated on the Affymetrix platform and includes a tool for data annotation using ontologies. Detailed information on the experiment, methods, reagents and signal intensity data can be captured in a systematic format. Reports screens permit the user to query the database, to view annotation on individual experiments and provide summary statistics. MiMiR has tools for automatic upload of the data from the microarray scanner and export to databases using MAGE-ML. Conclusion MiMiR facilitates microarray data management, annotation and exchange, in line with international guidelines. The database is valuable for underpinning research activities and promotes a systematic approach to data handling. Copies of MiMiR are freely available to academic groups under licence.

  3. Gasto y financiación de las casas reales de Felipe III

    Directory of Open Access Journals (Sweden)

    Carlos Javier de CARLOS MORALES

    2009-12-01

    Full Text Available RESUMEN: La situación económica de las Casas reales en tiempos de Felipe III reflejó una de las características básicas de la Real Hacienda castellana: la acumulación de atrasos y débitos daba lugar a un pasivo que tenía que ser trasladado de ejercicio en ejercicio. Esta dinámica no sólo era consecuencia de unos gastos corrientes crecientes, sino sobre todo de la ausencia de una fuente de sostenimiento fija a disposición del maestro de la cámara, cuya dependencia de la Tesorería general era causa del «déficit flotante» que debía manejar de año en año. Ante esta situación, en el reinado de Felipe III no dejaron de realizarse intentos para ajustar los ingresos y gastos y para dotar a las Casas reales de unos medios estables de sostenimiento, como la asignación de los millones. Pero las vicisitudes padecidas por la Real Hacienda impidieron la superación de la crónica falta de liquidez del erario, y determinaron que el recurso al crédito fuera una forma ineludible de financiación de las Casas reales.ABSTRACT: The economic situation of the Royal Houses in the times of Felipe the Third reflect one of the basic characteristics of the castilian Royal Treasury: the accumulation of arrears and debits caused liabilities that had to be transferred from financial year to financial year. These happenings were not only the consequence of growing ordinary expenses, but also the absence of a source of fixed maintenance at the chambermaster disposition, whose dependence of the general Treasury was the reason for a «floating déficit» he had to manage year after year. Confronted with this situation, during Felipe the Third's reign, there were any number of attempts to try to adjust the income and the expenses, and to provide the Royal Houses of stable means of maintenance, such as asigning the millions possessed. But the ups and downs suffered by the Royal Treasury didn't allow the overcoming of the chronic lack of settlement in the

  4. Heat transfer in simple houses; Transferencia de calor en casas habitacion

    Energy Technology Data Exchange (ETDEWEB)

    Porta, Miguel Angel; Rubio, Eduardo; Fernandez, Jose Luis [Centro de Investigaciones Biologicas del Noroeste, Baja California Sur, (Mexico); Gomez Munoz, Victor [Centro Interdiciplinario de Ciencias Marinas, Baja California Sur (Mexico)

    2000-07-01

    A lumped parameter model is used to represent, with a high degree of precision, the temperature and comfort evolution with the time of a simple house, under any hot, extreme weather variation. Results are validated by experimental work in physical models, built to scale 1:2, with materials and building techniques typical of social interest housing in Baja California, Mexico. With the mathematical model properly calibrated, adequately validated heat transfer coefficients between walls, ceiling and windows are calculated. Sensitivity analyses lead to values of heat loads in simple houses with varying shapes, orientation, shading devices, and construction materials and techniques. Energy balance in the present work is achieved by means of three simultaneous equations, each depicting energy equilibrium in one of the basic building elements: the window glazing, the building materials, and inside air. Simultaneous solution of the equations is accomplished with of the Kutta method, which yields the representative temperature along the day of each of the components, while heat flow among them is calculated, together with thermal exchange with the environment. Comfort levels, energy consumption and saving are hence easily derived, and the economical pertinence of passive elements can be evaluated. [Spanish] Este trabajo presenta un modelo matematico de parametros concentrados que representa, de manera apropiada, el comportamiento de una casa habitacion tipica a lo largo de un dia cualquiera. Los resultados se validan mediante la experimentacion en modelo fisico, donde se ensayan casetas de material y dimensiones similares a las casas de interes social, a escala 1:2. Una vez que se ha calibrado el modelo, se pueden determinar, mediante corridas apropiadas en computadora, los coeficientes especificos de transferencia de calor en muros, ventanas y techo. Los analisis subsecuentes de sensibilidad producen informacion util para conocer los requerimientos energeticos de cada casa

  5. La Casa de las Atarazanas de Valencia y Joan del Poyo (I

    Directory of Open Access Journals (Sweden)

    Iborra Bernad, Federico

    2007-06-01

    Full Text Available

    The construction of the House of the Dockyards in the coast line of the city by the local government was the result of the urban development policy of Valencia, showing that the city itself was centred in showing an image of propriety and beauty in every place, and also the influence of Martin I and his unsatisfied wishes of constructing a palace near the coast of Barcelona. Despite the fact that the original purpose of the building was to be used a warehouse of the port, the needs of the local government forced it to extend its functions turning it into a palace receiving prominent figures and being the emplacement of many ceremonies and banquets. The importance of the House of the Dockyards can be appreciated in its dimensions, as we can see in the engravings and landscapes illustrations of El Grao, and in the work produced by Joan del Poyo after returning from Barcelona, where he served the king Martin I, probably in the Royal Palace of the city.



    La construcción de la Casa de las Atarazanas en la línea litoral de la urbe por parte del gobierno municipal se debió tanto a la política urbanística emprendida por el patriciado urbano centrada en mostrar una imagen de belleza y decoro en todos sus frentes, como a la influencia que pudo haber ejercido Martín I en el reino de Valencia, y su deseo no satisfecho de edificar en Barcelona un palacio cercano a la costa. Aunque en un primer momento la finalidad del edificio fue la de servir de almacén de los productos del puerto, las necesidades de gobierno hizo ampliar sus funciones, asemejándose más a la de una casa o palacio, que acogería a personajes ilustres en su llegada marítima y sería el emplazamiento de ceremonias y ágapes. La importancia de la Casa de las Atarazanas se aprecia tanto en sus grandes dimensiones, como constatan los grabados e ilustraciones paisajísticas del

  6. Pensées intimes

    CERN Document Server

    Einstein, Albert

    2000-01-01

    A quelqu'un qui lui demandant pourquoi les hommes pouvaient découvrir les atomes, mais pas les moyens de les contrôler, Einstein répondit : " C'est simple, mon ami : parce que la politique est plus difficile que la physique ". Albert Einstein était un écrivain prolifique dont l'œuvre abonde en aphorismes. Les 550 citations de ce recueil, tirées des quelque 40 000 documents des Archives Einstein, nous font découvrir le Einstein de la légende, l'ami des écoliers et des étudiants fauchés, le philosophe de la vie quotidienne, doux et ironique, mais aussi la face plus sombre, parfois désespérée, de ce grand génie de l'ère moderne. Qu'il s'exprime sur des sujets aussi variés que l'Amérique et les Américains, l'Allemagne et les Allemands, les Juifs et le sionisme, la guerre et le pacifisme, la politique, la religion et la science, ou sur des thèmes plus personnels, tels que l'amour et le mariage, la jeunesse et la vieillesse l'avortement ou l'homosexualité, ses propos restent toujours mordants,...

  7. 76 FR 15936 - Designation for the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND...

    Science.gov (United States)

    2011-03-22

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Designation for the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND; and Plainview, TX Areas AGENCY: Grain Inspection, Packers and Stockyards Administration, USDA. ACTION: Notice...

  8. 78 FR 43850 - Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ...

    Science.gov (United States)

    2013-07-22

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND and Plainview, TX; Areas; Request for Comments on the Official Agencies Servicing These Areas AGENCY: Grain...

  9. 75 FR 52925 - Opportunity for Designation in the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande...

    Science.gov (United States)

    2010-08-30

    ... DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in the Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ; Fargo, ND; Grand Forks, ND; and Plainview, TX Areas; Request for Comments on the Official Agencies Servicing These Areas AGENCY...

  10. Identification of miR-93 as a suitable miR for normalizing miRNA in plasma of tuberculosis patients.

    Science.gov (United States)

    Barry, Simone E; Chan, Brian; Ellis, Magda; Yang, YuRong; Plit, Marshall L; Guan, Guangyu; Wang, Xiaolin; Britton, Warwick J; Saunders, Bernadette M

    2015-07-01

    Tuberculosis (TB) remains a major public health issue. New tests to aid diagnoses and monitor the response to therapy are urgently required. There is growing interest in the use of microRNA (miRNA) profiles as diagnostic, prognostic or predictive markers in a range of clinical and infectious diseases, including Mycobacterium tuberculosis infection, however, challenges exist to accurately normalise miRNA levels in cohorts. This study examined the appropriateness of 12 miRs and RNU6B to normalise circulating plasma miRNA levels in individuals with active TB from 2 different geographical and ethnic regions. Twelve miRs (let-7, miR-16, miR-22, miR-26, miR-93, miR-103, miR-191, miR-192, miR-221, miR-423, miR-425 and miR-451) and RNU6B were selected based on their reported production by lung cells, expression in blood and previous use as a reference miRNA. Expression levels were analysed in the plasma of newly diagnosed TB patients from Australia and China compared with individuals with latent TB infection and healthy volunteers. Analysis with both geNorm and NormFinder software identified miR-93 as the most suitable reference miR in both cohorts, either when analysed separately or collectively. Interestingly, there were large variations in the expression levels of some miRs, in particular miR-192 and let-7, between the two cohorts, independent of disease status. These data identify miR-93 is a suitable reference miR for normalizing miRNA levels in TB patients, and highlight how environmental, and possibly ethnic, factors influence miRNA expression levels, demonstrating the necessity of assessing the suitability of reference miRs within the study population. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  11. miRNA Signatures of Insulin Resistance in Obesity.

    Science.gov (United States)

    Jones, Angela; Danielson, Kirsty M; Benton, Miles C; Ziegler, Olivia; Shah, Ravi; Stubbs, Richard S; Das, Saumya; Macartney-Coxson, Donia

    2017-10-01

    Extracellular microRNAs (miRNAs) represent functional biomarkers for obesity and related disorders; this study investigated plasma miRNAs in insulin resistance phenotypes in obesity. One hundred seventy-five miRNAs were analyzed in females with obesity (insulin sensitivity, n = 11; insulin resistance, n = 19; type 2 diabetes, n = 15) and without obesity (n = 12). Correlations between miRNA level and clinical parameters and levels of 15 miRNAs in a murine obesity model were investigated. One hundred six miRNAs were significantly (adjusted P ≤ 0.05) different between controls and at least one obesity phenotype, including miRNAs with the following attributes: previously reported roles in obesity and altered circulating levels (e.g., miR-122, miR-192); known roles in obesity but no reported changes in circulating levels (e.g., miR-378a); and no current reported role in, or association with, obesity (e.g., miR-28-5p, miR-374b, miR-32). The miRNAs in the latter group were found to be associated with extracellular vesicles. Forty-eight miRNAs showed significant correlations with clinical parameters; stepwise regression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R 2  = 0.57, P = 7.5 × 10 -8 ). Both miR-378a and miR-122 were perturbed in metabolically relevant tissues in a murine model of obesity. This study expands on the role of extracellular miRNAs in insulin-resistant phenotypes of obesity and identifies candidate miRNAs not previously associated with obesity. © 2017 The Obesity Society.

  12. João Andresen (1920/1967) : o projecto da casa Ruben A.

    OpenAIRE

    Pinto, Luís Miguel Rodrigues Moreira

    2011-01-01

    Dissertação de mestrado em Arquitectura. Exame público realizado em 11 de Julho de 2011. A dissertação aborda o projecto da Casa em Montedor que o arquitecto João Andresen projecta no final dos anos 40 para o escritor Ruben A. O ambiente de adesão e afirmação moderna que se vive na arquitectura portuguesa explica a interpretação genérica de um programa específico, a prioridade dada aos aspectos funcionais e o modo como a construção se relaciona, por oposição, com a paisagem. A confronta...

  13. Restauración de la casa doble de Le Corbusier en la Weissenhofsiedlung

    Directory of Open Access Journals (Sweden)

    Arne Fentzloff

    2014-07-01

    Full Text Available La Casa Doble diseñada por Le Corbusier en 1927 para la Weissenhofsiedlung constituye un hito en el diseño y construcción de viviendas en el Movimiento Moderno. Su precario estado de conservación requería una restauración que la Fundación Wüstenrot ha acometido con la voluntad no de repristinar necesariamente a su condición originaria, sino de restaurar el conjunto y habilitarlo para la visita pública conservando al menos parcialmente las diversas reformas y adaptaciones de uso que había sufrido estas viviendas pareadas durante sus años de historia. El texto explica abundantes detalles constructivos de su proceso de diseño y construcción y revela las soluciones técnicas adoptadas durante la restauración.

  14. Convocatoria al Premio Literario Casa de las Américas 2004

    Directory of Open Access Journals (Sweden)

    Boletín Cultural y Bibliográfico Banco de la República

    2001-09-01

    Full Text Available Premio extraordinario sobre estudios de la mujer. La Casa de las Américas convoca, por segunda vez, al Premio extraordinario de ensayo sobre estudios de la mujer, dedicado a ampliar el conocimiento de obras, figuras o grupos de mujeres latinoamericanas y del Caribe que se hayan destacado en cualquier campo de la vida intelectual, social o política. Los libros que concursen se someterán a las bases generales del Premio y podrán ser enviados a cualquiera de los lugares enumerados en la base 8 antes del 30 de noviembre de 2003. El fallo del jurado será dado a conocer conjuntamente con el de los demás premios en enero de 2004.

  15. “En tu casa o en la mía’: the interview as infotainment

    Directory of Open Access Journals (Sweden)

    Marián Alonso González

    2016-11-01

    Full Text Available The fight for viewers has led to a spectacular range of television content on offer where boundaries of genres have disappeared giving rise to new formats of hybrid television programmes. This has given a new lease of life to interviews as a genre of infotainment. The present article analyses the programme ‘En tu casa o en la mía’, a new type of interview of famous personalities which combines information and entertainment with elements that are very similar to the info-show. We shall embark on a study of this media product, its narrative, treatment, structure and the technique used so as to describe the elements that make it an example of gender hybridization in today’s television programmes.

  16. Evaluación de los resultados del programa 'Parto en el hospital, comadrona en casa'

    OpenAIRE

    Crespo Mirasol, Esther; España, M.Carmen; Basteiro, Elena; Zegarra, Mary Michel; Botet Mussons, Francisco; Pérez, José María; Arranz Betegón, Ángela; Palacio i Riera, Montserrat

    2015-01-01

    Objetivo: Describir las características y la evolución clínica de las puérperas y los neonatos incluidos en un programa de alta precoz hospitalaria. Material y método: Estudio observacional y descriptivo de la población incluida en el programa «Parto en el hospital, comadrona en casa», del Hospital Clínic de Barcelona, desde octubre de 2010 hasta abril de 2013. Resultados: Participaron un total de 150 madres, con una edad (media ± desviación estándar) de 32 ± 4 años. El 70% (n= 105) eran mult...

  17. La casa de Fermina Daza. Retrato de Gabo con loro al fondo

    OpenAIRE

    Rodríguez Blanco, Sergio

    2014-01-01

    Extracto de la crónica: "Gabriel García Márquez ubicó aquí la casa de soltera de la altiva Fermina Daza, la protagonista de El amor en los tiempos del cólera, una novela ambientada en una población imaginaria que se parece en todo a Cartagena de Indias a principios del siglo XX. Cada día, para obtener una mirada furtiva de su amada, el joven Florentino Ariza iba al parque de los Evangelios y fingía leer poemas sentado a la sombra de los almendros, desde el escaño menos visible de los que rode...

  18. Conquista, dominación y alteridad en Bartolomé de Las Casas

    Directory of Open Access Journals (Sweden)

    Luis Adrián Mora Rodríguez

    2011-11-01

    Full Text Available El presente artículo pretende efectuar un acercamiento innovador a la obra de Bartolomé de Las Casas. Se plantea que dicha obra debe ser abordada como una obra de teoría y de filosofía política, más allá de su importancia como obra ética o histórica. Se argumenta que dicho acercamiento permite observar y criticar las variantes del discurso lascasiano y profundizar sus conexiones y puentes con el pensamiento político moderno. Se trazan de esta manera algunas líneas de investigación posibles.

  19. CASA: An Efficient Automated Assignment of Protein Mainchain NMR Data Using an Ordered Tree Search Algorithm

    International Nuclear Information System (INIS)

    Wang Jianyong; Wang Tianzhi; Zuiderweg, Erik R. P.; Crippen, Gordon M.

    2005-01-01

    Rapid analysis of protein structure, interaction, and dynamics requires fast and automated assignments of 3D protein backbone triple-resonance NMR spectra. We introduce a new depth-first ordered tree search method of automated assignment, CASA, which uses hand-edited peak-pick lists of a flexible number of triple resonance experiments. The computer program was tested on 13 artificially simulated peak lists for proteins up to 723 residues, as well as on the experimental data for four proteins. Under reasonable tolerances, it generated assignments that correspond to the ones reported in the literature within a few minutes of CPU time. The program was also tested on the proteins analyzed by other methods, with both simulated and experimental peaklists, and it could generate good assignments in all relevant cases. The robustness was further tested under various situations

  20. Evaluación sustentable "CASA HABITACION" en el Municipio de Tlaxcala, Tlax. México.

    OpenAIRE

    Raúl Molina Rivera

    2012-01-01

    El artículo mostrará la evaluación realizada por medio del software de diseño Bioclimática Ecotect Analysis1 y de evaluación sustentable como ARTEBES2 a un proyecto de casa habitación que fue sometido a modificaciones sencillas, económicas y muy accesibles en la región, que optimizaran el uso de las energías renovables y ayudarán a la reducción de consumo de energías no-renovables para reducir los gastos económicos necesarios para el funcionamiento de la vivienda. Presentando una breve descri...

  1. O Programa Minha Casa Minha Vida e seus resultados formais em Uberaba (MG: residencial Tancredo Neves

    Directory of Open Access Journals (Sweden)

    Carmem Silvia Maluf

    2014-12-01

    Full Text Available This article proposes the discussion of the housing policy “Minha Casa Minha Vida” (“My House My Life”, its consequences and recurrent transformations for urban space, with focus in the analysis of the urban morphology resulting from Tancredo Neves residential subdivision, located in the municipality of Uberaba (MG, Brasil. This social housing has some single features, differing of other social housing, since the public intended to misuse of Permanent Preservation Areas (APP by the residents. The results of this analysis reinforce the importance of government in promoting housing, and identifies the recurrent reproducibility of housing models, and show how this proliferation of housing units impacts on urban morphology, bringing with questionable consequences for the landscape.

  2. Cultural diversity in Brazilian children’s literature: The project Literatura em Minha Casa in question

    Directory of Open Access Journals (Sweden)

    Flávia Ferreira de Paula

    2016-08-01

    Full Text Available This paper intends to search for representations of Brazilian cultural diversity in children’s literature of the Programa Nacional Biblioteca da Escola [National Program of School Library] (PNBE, in the editions of 2001, 2002, and 2003, years of the project Literatura em Minha Casa [Literature in My House], especially those addressed to fourth and fifth grades of Elementary School. The selection criteria of works claimed that the collections should “[…] present a small picture of the Brazilian culture […]” (Brasil, 2001; 2002; 2003, p. 12, understanding that culture as characterized by diversity. Therefore, the analysis was divided into two phases: the first dealt with ethnic plurality and the second with culture and regionalism. In general, the results showed that among 120 works analyzed, 15 had ethnic-racial diversity and 12 works presented aspects of regionalism and culture from different parts of Brazil.

  3. The Discursive Representation of Dictatorship in Lygia Bojunga’s A casa da madrinha

    Directory of Open Access Journals (Sweden)

    Alice Atsuko Matsuda

    2015-07-01

    Full Text Available The children’s novel A casa da madrinha [The Godmother's House], by Lygia Bojunga (2002, published in 1978, incorporates libertarian ideals of the children’s and youth production of that decade. Its plot breaks with the tradition of euphoric literary production around the 1940s and 1950s, intended to children and young people, talks about taboo subjects like abandonment of minors and child labor, bringing to the center an inhuman social reality in which children and youths are neither protected nor supported or respected, having their rights disregarded. This justify, thus, the objective of this text, which is to analyze how these ideals are configured in the discursive representation of said work, considering that it was published during a military dictatorship.

  4. Housing for the poor: Implementation and impact of Tu Casa program in Tijuana

    Directory of Open Access Journals (Sweden)

    Ana Elizabeth Jardón Hernández

    2009-01-01

    Full Text Available This study assesses the operation and some major results of most important federal housing program focus on households in poverty situation, with particular emphasis on their instrumentation process and impacts in Tijuana’s housing problem for poor families. The exam aims to analyses the design changes of the program that forced its transformation from Vivah to Tu Casa, and the operational difficulties for a proper implementation in an urban context, as well as its limited impact for solving popular housing needs. It also seeks to weigh the importance of government subsidies to acquire or improve housing, in their progressive modality, as an alternative for social segments excluded from any other public or private financing option.

  5. Evaluation of the Township Proper Carrying Capacity over Qinghai-Tibet plateau by CASA model

    Science.gov (United States)

    Wu, Chengyong; Cao, Guangchao; Xue, Huaju; Jiang, Gang; Wang, Qi; Yuan, Jie; Chen, Kelong

    2018-01-01

    The existing study of proper carrying capacity (PCC) has mostly focused on province or county administrative units, which can only macroscopically master the quantitative characteristics of PCC, but could not effectively take some animal husbandry management measures that are pertinent and operational. At town-scale, this paper used CASA model to estimate the PCC in Mongolian Autonomous County of Henan, Qinghai province, China,with serious grassland degeneration that mainly caused by overgrazing. The results showed that the PCC throughout the County was 950,417 sheep unit. For the township, the PCC of Saierlong and Duosong were the largest (247,100 sheep unit) and the smallest (82,016 sheep unit) respectively. This study will provide reference data for developing sustainable development of town-scale pasture policies and also will help to evaluate the health status of the alpine grassland ecosystem on Qinghai-Tibet plateau.

  6. The intertext of modernism in Crônica da casa assassinada, de Lúcio Cardoso

    Directory of Open Access Journals (Sweden)

    William Valentine Redmond

    2015-11-01

    Full Text Available AbstractThis article reflects on the many opinions about the author of the of Crônica da casa assassinada as a modernist or postmodernist writer.  Examining the narrative techniques used by the author, maybe influenced by his wide reading of foreign literatures , it may be possible to clarify a little the question of the position of Lucio Cardoso in relation to the literary movements of the twentieth century. His personal experience as a writer passes through the process of impersonalisation, transforming his masterpiece into a universal symbol.  It is hoped that this paper will show how this transformation of his personal experience comes across to the readers in the form of a modernist and not as some say, a post modernist novel. Resumo: Este artigo reflete sobre as muitas opiniões acerca do autor da Crônica da casa assassinada como um escritor modernista ou pós-modernista. Examinando as técnicas narrativas utilizadas pelo autor, talvez influenciado por sua vasta leitura de literaturas estrangeiras relatadas,  seria possível clarear um pouco esta questão da posicionamento de Lucio Cardoso com relação aos movimentos literários do século XX. A experiência pessoal do escritor passa por um processo de impessoalidade, através da transmutação e amalgamação, transformando a obra em símbolo universal. Espera-se com esta comunicação discutir o modo como essa transmutação chega ao leitor em forma de um romance modernista e não, como às vezes se afirma, como um romance pós-modernista. 

  7. Cointegrating MiDaS Regressions and a MiDaS Test

    OpenAIRE

    J. Isaac Miller

    2011-01-01

    This paper introduces cointegrating mixed data sampling (CoMiDaS) regressions, generalizing nonlinear MiDaS regressions in the extant literature. Under a linear mixed-frequency data-generating process, MiDaS regressions provide a parsimoniously parameterized nonlinear alternative when the linear forecasting model is over-parameterized and may be infeasible. In spite of potential correlation of the error term both serially and with the regressors, I find that nonlinear least squares consistent...

  8. miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma.

    Science.gov (United States)

    Khella, H W Z; Bakhet, M; Allo, G; Jewett, M A S; Girgis, A H; Latif, A; Girgis, H; Von Both, I; Bjarnason, G A; Yousef, G M

    2013-10-01

    MicroRNAs (miRNAs) play a crucial role in tumor progression and metastasis. We, and others, recently identified a number of miRNAs that are dysregulated in metastatic renal cell carcinoma compared with primary renal cell carcinoma. Here, we investigated three miRNAs that are significantly downregulated in metastatic tumors: miR-192, miR-194 and miR-215. Gain-of-function analyses showed that restoration of their expression decreases cell migration and invasion in renal cell carcinoma cell line models, whereas knockdown of these miRNAs resulted in enhancing cellular migration and invasion abilities. We identified three targets of these miRNAs with potential role in tumor aggressiveness: murine double minute 2, thymidylate synthase, and Smad Interacting protein 1/zinc finger E-box binding homeobox 2. We observed a convergent effect (the same molecule can be targeted by all three miRNAs) and a divergent effect (the same miRNA can control multiple targets) for these miRNAs. We experimentally validated these miRNA-target interactions using three independent approaches. First, we observed that miRNA overexpression significantly reduces the mRNA and protein levels of their targets. In the second, we observed significant reduction of the luciferase signal of a vector containing the 3'UTR of the target upon miRNA overexpression. Finally, we show the presence of inverse correlation between miRNA changes and the expression levels of their targets in patient specimens. We also examined the prognostic significance of miR-215 in renal cell carcinoma. Lower expression of miR-215 is associated with significantly reduced disease-free survival time. These findings were validated on an independent data set from The Cancer Genome Atlas. These results can pave the way to the clinical use of miRNAs as prognostic markers and therapeutic targets.

  9. The regulatory epicenter of miRNAs

    Indian Academy of Sciences (India)

    Bioresource Technology, Council of Scientific & Industrial Research, Palampur 176 061, HP, India. *Corresponding .... miRNA stem and loop regions, interacting with Drosha for .... a double-stranded element, having one strand from the 5′.

  10. Universal MI definition update for cardiovascular disease.

    Science.gov (United States)

    White, Harvey; Thygesen, Kristian; Alpert, Joseph S; Jaffe, Allan

    2014-01-01

    The new third universal definition of myocardial infarction (MI) is based on troponin elevation together with ischemic symptoms, ischemic ECG changes, and imaging evidence. MIs are classified into five types as to whether they are spontaneous, secondary to imbalance between coronary artery blood supply and demand, related to sudden death, or related to revascularization procedures. The definition is based on a rise and/or fall in troponin levels occurring in a clinical setting. There have been modifications over previous definitions with adding intracoronary thrombus as a criterion, adding a new type of MI type 4c, and raising the cutpoint for the diagnosis of MI related to percutaneous coronary intervention to five times the 99(th) percentile upper reference limit and requiring evidence of ischemia or angiographic complications. In clinical practice, trials, and registries, different definitions are used. There is a need for consistency with regard to the definition of MI and the universal definition should be implemented.

  11. miRNAting control of DNA methylation

    Indian Academy of Sciences (India)

    miRNAting control of DNA methylation. ASHWANI ... function and biological process ... Enrichment analysis of the genes methylated by DRM2 for molecular function and biological ... 39(3), June 2014, 365–380, © Indian Academy of Sciences.

  12. miRNAtools: Advanced Training Using the miRNA Web of Knowledge.

    Science.gov (United States)

    Stępień, Ewa Ł; Costa, Marina C; Enguita, Francisco J

    2018-02-16

    Micro-RNAs (miRNAs) are small non-coding RNAs that act as negative regulators of the genomic output. Their intrinsic importance within cell biology and human disease is well known. Their mechanism of action based on the base pairing binding to their cognate targets have helped the development not only of many computer applications for the prediction of miRNA target recognition but also of specific applications for functional assessment and analysis. Learning about miRNA function requires practical training in the use of specific computer and web-based applications that are complementary to wet-lab studies. In order to guide the learning process about miRNAs, we have created miRNAtools (http://mirnatools.eu), a web repository of miRNA tools and tutorials. This article compiles tools with which miRNAs and their regulatory action can be analyzed and that function to collect and organize information dispersed on the web. The miRNAtools website contains a collection of tutorials that can be used by students and tutors engaged in advanced training courses. The tutorials engage in analyses of the functions of selected miRNAs, starting with their nomenclature and genomic localization and finishing with their involvement in specific cellular functions.

  13. Mi-DISCOVERER: A bioinformatics tool for the detection of mi-RNA in human genome.

    Science.gov (United States)

    Arshad, Saadia; Mumtaz, Asia; Ahmad, Freed; Liaquat, Sadia; Nadeem, Shahid; Mehboob, Shahid; Afzal, Muhammad

    2010-11-27

    MicroRNAs (miRNAs) are 22 nucleotides non-coding RNAs that play pivotal regulatory roles in diverse organisms including the humans and are difficult to be identified due to lack of either sequence features or robust algorithms to efficiently identify. Therefore, we made a tool that is Mi-Discoverer for the detection of miRNAs in human genome. The tools used for the development of software are Microsoft Office Access 2003, the JDK version 1.6.0, BioJava version 1.0, and the NetBeans IDE version 6.0. All already made miRNAs softwares were web based; so the advantage of our project was to make a desktop facility to the user for sequence alignment search with already identified miRNAs of human genome present in the database. The user can also insert and update the newly discovered human miRNA in the database. Mi-Discoverer, a bioinformatics tool successfully identifies human miRNAs based on multiple sequence alignment searches. It's a non redundant database containing a large collection of publicly available human miRNAs.

  14. Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run.

    Science.gov (United States)

    Gomes, Clarissa P C; Oliveira, Getúlio P; Madrid, Bibiano; Almeida, Jeeser A; Franco, Octávio L; Pereira, Rinaldo W

    2014-11-01

    Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication. To investigate circulating muscle-specific miRNAs in recreational athletes. Three miRNAs from whole plasma before and after a half-marathon were analyzed by qPCR. MiR-1, -133a, and -206 significantly increased after the race. Increased levels of miRNAs after exercise point to potential biomarkers and to the possibility of being functional players following endurance training. These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.

  15. miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis

    DEFF Research Database (Denmark)

    Coskun, Mehmet; Bjerrum, Jacob Tveiten; Seidelin, Jakob Benedict

    2013-01-01

    were obtained endoscopically from patients with active UC or CD, quiescent UC or CD, as well as healthy controls. Total RNA was isolated and miRNA expression assessed using the miRNA microarray Geniom Biochip miRNA Homo sapiens (Febit GmbH, Heidelberg, Germany). Data analysis was carried out...... genes involved in various pathways, such as mitogen-activated protein kinase and cytokine signaling, which are both key signaling pathways in UC. CONCLUSION: The present study provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let-7e* are deregulated in patients with UC. The level...

  16. El mundo es un paisaje sonoro

    OpenAIRE

    Rezza, Sol

    2009-01-01

    El sonido es movimiento, sin movimiento no hay sonido. Nuestras vidas cotidianas están plagadas de sonidos, el mundo es un mundo sonoro. Soundscape, paisajes sonoros, postales sonoras, ambientes sonoros son algunos de los nombres con los que se define al sonido o a la combinación de sonidos que conforman un entono específico, es decir un ambiente sonoro.

  17. HISTORIZAR LA VIOLENCIA PUERTAS ADENTRO. EL CASO DE LA CASA YELA Y LA VIOLENCIA DE GENERO EN TALCA, 1964-2008

    OpenAIRE

    CARROLL HINER, HILLARY; CARROLL HINER, HILLARY

    2012-01-01

    Nuestra investigación se concentra en el caso de la Casa de la Mujer "Yela" en Talca, sede de una organización de mujeres - el Grupo Yela - y casa de acogida. La historia de esta Casa remite a una historia más larga de lucha y organización femenina y proponemos que las experiencias de las mujeres "Yela" tienen sus raíces en la llegada de las mujeres a las poblaciones del extremo barrio norte de Talca durante los años 60 y 70 y en las décadas de lucha colectiva emprendida por estas mujeres des...

  18. Recuperação de edifícios antigos com fachadas em azulejo : reabilitação da casa de Donães em Guimarães

    OpenAIRE

    Rodrigues, Joana Silva Lázaro

    2015-01-01

    Mestrado Integrado em Arquitectura Exame público realizado em 08 de Novembro de 2016 A presente dissertação tem como tema a "Recuperação de edifícios antigos com fachadas em azulejo". O objectivo geral desta dissertação consistiu em estudar a azelujaria de fachada, toda a sua beleza e importância em Portugal, compreendendo o importante desempenho deste material como revestimento de fachada. Não só no que diz respeito ao aspecto visual, à sua durabilidade, ao seu poder decorativo, que...

  19. Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer.

    Science.gov (United States)

    Chen, Zhanguo; Wu, Lili; Lin, Qi; Shi, Jing; Lin, Xiangyang; Shi, Liang

    2016-09-01

    Abnormal expression of microRNAs (miRNAs) plays an important role in development of several cancer types, including bladder cancer (BCa). However, the relationship between the ratio of miR-181/miR-100 and the prognosis of BCa has not been studied yet. The aim of this study was to evaluate the expression of miR-182, miR-100 and their clinical significance in BCa. Upregulation of miR-182 and down-regulation of miR-100 were validated in tissue specimens of 134 BCa cases compared with 148 normal bladder epithelia (NBE) specimens  using TaqMan-based real-time reverse transcription quantitative PCR (RT-qPCR). The diagnostic and prognostic evaluation of miR-182, miR-100, and miR-182/miR-100 ratio was also performed. miR-182 was upregulated in BCa and miR-100 was down-regulated in BCa compared with NBE (P ratio increased the diagnostic performance, yielding an AUC of 0.981 (97.01% sensitivity and 90.54% specificity). Moreover, miR-182/miR-100 ratio was associated with pT-stage, histological grade, BCa recurrence and carcinoma in situ (P analysis indicated that miR-182/miR-100 ratio was an independent prognostic factor for overall survival (Hazard ratio: 7.142; 95% CI: 2.106 - 9.891; P analysis revealed that high-level of miR-182/miR-100 ratio was significantly correlated with shortened survival time for BCa patients (P ratio may serve as a novel promising biomarker for diagnosis and survival prediction in BCa. Further studies are needed to elucidate the role of miR-182/miR-100 ratio as a non‑invasive diagnostic tool for BCa.

  20. Knock-down of miR-221 and miR-222 in the radiosensitization of breast cancer cells

    International Nuclear Information System (INIS)

    Zhang Chunzhi; Kang Chunsheng; Cao Yongzhen; Pu Peiyu; Lu Zhonghong; Du Yue

    2009-01-01

    Objective: To investigate the radiosensitizing effect of knock-down of miR-221 miR-222 on MCF-7 human breast cancer cells and explore the possible mechanism. Methods: Antisense oligonucleotides of miR-221 and miR-222 (AS-miR-221 and AS-miR-222), mediated by lipofectamine, were transfected to MCF-7 cells to knock down miR-221 and miR-222, Northern blotting was conducted to detect the expression of miR-221 and miR-222 in transfected cells. The cell apoptosis was detected by flow cytometry and Caspase-3 and Caspase-7 activity assay. Clonogenic assay was used to measure the sensitizing enhancement ratio. Target genes of miR-221 and miR-222 relevant to radio-sensitivity were searched using bioinformatics analysis. The targeted protein expression was determined by Western blot analysis. Results: The expression of miR-221 and miR-222 in the AS-miR-221/222 cells determined by Northern blotting was significantly reduced. Compared with the control group, the cell apoptosis and mitotic cell death after the radiation were significantly higher in AS-miR-221/222 cells. The sensitizing enhancement ratio was 1.87. Based on bioinformatics analysis, PTEN was a target gene of miR-221 and miR-222 which could enhance the radiosensitivity of MCF-7 cells. In AS-miR-221/222 cells, the expression of PTEN was up-regulated while pAkt down-regulated. Conclusions: AS-miR-221 and AS-miR-222 may enhance the radiosensitivity of MCF-7 breast cancer cells by up-regulating the expression of PTEN. (authors)

  1. Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

    DEFF Research Database (Denmark)

    Veno, Morten T.; Veno, Susanne T.; Rehberg, Kati

    2017-01-01

    The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across...

  2. Decreased miR-128 and increased miR-21 synergistically cause podocyte injury in sepsis.

    Science.gov (United States)

    Wang, Shanshan; Wang, Jun; Zhang, Zengdi; Miao, Hongjun

    2017-08-01

    Glomerular podocytes are injured in sepsis. We studied, in a sepsis patient, whether microRNAs (miRNAs) play a role in the podocyte injury. Podocytes were cultured and treated with lipopolysaccharide (LPS). Filtration barrier function of podocyte was analyzed with albumin influx assay. Nephrin level was analyzed with reverse transcription polymerase chain reaction (RT-PCR) and western blot. MiRNAs were detected using miRNAs PCR Array and in situ hybridization. MiRNA target sites were evaluated with luciferase reporter assays. LPS impaired the filtration barrier function of podocytes. MiR-128 level was decreased and miR-21 level was increased in podocytes in vitro and in the sepsis patient. The decrease in miR-128 was sufficient to induce the loss of nephrin and the impairment of filtration barrier function, while the increase of miR-21 exacerbated the process. Snail and phosphatase and tensin homolog (PTEN) were identified as the targets of miR-128 and miR-21. Decreased miR-128 induced Snail expression, and the increased miR-21 stabilized Snail by regulating the PTEN/Akt/GSK3β pathway. Supplementation of miR-128 and inhibition of miR-21 suppressed Snail expression and prevented the podocyte injury induced by LPS. Our study suggests that decreased miR-128 and increased miR-21 synergistically cause podocyte injury and are the potential therapeutic targets in sepsis.

  3. BOOK REVIEWS BOEKRESE ISlES

    African Journals Online (AJOL)

    colour-picture ever must be that of Lactrodactu mactans (black widow spider); incidentally the button pider is mi ing. Altogether this book must be considered one of the best general text-books of medicine. It is of particular use to student, and for the most part the articles can be recommended as being highly authoritative. P.l..

  4. Perfil mediacional de mães sociais que atuam em instituições de acolhimento

    OpenAIRE

    Tomás,Débora Nogueira; Vectore,Celia

    2012-01-01

    Este artigo aborda as interações entre mãe social e criança em situação de acolhimento, em instituição tipo casa-lar, devido à importância de mediações adequadas para o desenvolvimento infantil. Participaram quatro mães sociais, responsáveis pelas crianças de até seis anos de idade. Foram feitas observações do cotidiano institucional, entrevistas semiestruturadas com as participantes e vídeo-gravações de momentos de interação durante atividades rotineiras, como banho e alimentação. Foram real...

  5. Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status

    DEFF Research Database (Denmark)

    Rask, Lene; Balslev, Eva; Søkilde, Rolf

    2014-01-01

    PURPOSE: Therapeutic decisions in breast cancer are increasingly guided by prognostic and predictive biomarkers. Non-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features. One...... of the most consistently up-regulated miRNAs is miR-21. Here, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients. In the same patients, we also compared miR-21 expression with the expression of its presumed target...... PTEN. METHODS: Both microarray and RT-qPCR techniques were used to assess miRNA expression levels in lymph node-positive and -negative human invasive ductal carcinoma tissues. Simultaneously, PTEN protein expression levels were assessed using immunohistochemistry. RESULTS: miR-486-5p and miR-139-5p...

  6. miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.

    Directory of Open Access Journals (Sweden)

    Kinya Okamoto

    Full Text Available BACKGROUND AND AIMS: Cholangiocarcinoma (CCA is highly resistant to chemotherapy, including gemcitabine (Gem treatment. MicroRNAs (miRNAs are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play important roles in the chemosensitivity of tumors. Here, we examined the relationship between miRNA expression and the sensitivity of CCA cells to Gem. METHODS: Microarray analysis was used to determine the miRNA expression profiles of two CCA cell lines, HuH28 and HuCCT1. To determine the effect of candidate miRNAs on Gem sensitivity, expression of each candidate miRNA was modified via either transfection of a miRNA mimic or transfection of an anti-oligonucleotide. Ontology-based programs were used to identify potential target genes of candidate miRNAs that were confirmed to affect the Gem sensitivity of CCA cells. RESULTS: HuCCT1 cells were more sensitive to Gem than were HuH28 cells, and 18 miRNAs were differentially expressed whose ratios over ± 2log2 between HuH28 and HuCCT1. Among these 18 miRNAs, ectopic overexpression of each of three downregulated miRNAs in HuH28 (miR-29b, miR-205, miR-221 restored Gem sensitivity to HuH28. Suppression of one upregulated miRNA in HuH28, miR-125a-5p, inhibited HuH28 cell proliferation independently to Gem treatment. Selective siRNA-mediated downregulation of either of two software-predicted targets, PIK3R1 (target of miR-29b and miR-221 or MMP-2 (target of miR-29b, also conferred Gem sensitivity to HuH28. CONCLUSIONS: miRNA expression profiling was used to identify key miRNAs that regulate Gem sensitivity in CCA cells, and software that predicts miRNA targets was used to identify promising target genes for anti-tumor therapies.

  7. Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci.

    Directory of Open Access Journals (Sweden)

    Stefano Comazzetto

    2014-10-01

    Full Text Available Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive of several meiotic stages and spermiogenesis (terminal spermatozoa differentiation are transcriptionally inert, indicating the potential importance for the post-transcriptional microRNA (miRNA gene-silencing pathway therein. We found the expression of miRNA generating enzyme Dicer within spermatogenesis peaks in meiosis with critical functions in spermatogenesis. In an expression screen we identified two miRNA loci of the miR-34 family (miR-34b/c and miR-449 that are specifically and highly expressed in post-mitotic male germ cells. A reduction in several miRNAs inclusive of miR-34b/c in spermatozoa has been causally associated with reduced fertility in humans. We found that deletion of both miR34b/c and miR-449 loci resulted in oligoasthenoteratozoospermia in mice. MiR-34bc/449-deficiency impairs both meiosis and the final stages of spermatozoa maturation. Analysis of miR-34bc-/-;449-/- pachytene spermatocytes revealed a small cohort of genes deregulated that were highly enriched for miR-34 family target genes. Our results identify the miR-34 family as the first functionally important miRNAs for spermatogenesis whose deregulation is causal to oligoasthenoteratozoospermia and infertility.

  8. Early Sámi visual artists - Western fine art meets Sámi culture

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    Tuija Hautala-Hirvioja

    2014-04-01

    Full Text Available Johan Turi (1854–1936, Nils Nilsson Skum (1872–1951 and John Savio (1902–1938 were among the first Sámi visual artists. The production of their art work occurred between the 1910s and the early 1950s. Sámi aesthetics had its basis in folklore, i.e., handicraft or duodji, which did not follow the principle of art for art’s sake but combined beauty and practicality. Art was part of community life. Not until the 1970s was the word daidda, which is Finnish in origin and which means “art”, adopted into the Sámi language. Turi and Skum became famous through their books. They drew and wrote in order to pass the traditional knowledge of their people on to succeeding generations. They also wanted to introduce Sámi life and culture to non-Sámi people. One typical feature of their work is that they depicted Sáminess in a realistic way and sought to strengthen and preserve the Sámi identity through their art. In Turi and Skum’s work, both the documentation of community life and their own personal expression were strongly present and equally important; for this reason their pictures and texts have both practical and aesthetic dimensions. They did not attend school and were self-taught artists. The third pioneer of Sámi visual arts was John Savio, who, unlike the other two, attended secondary school and studied visual arts both independently and under the guidance of a mentor. He expressively combined Western ways of depiction with Sámi subjects. My article examines what made these early Sámi artists change over from Sámi handicraft, duodji, to Western visual arts, how they used Western pictorial conventions in dealing with their Sámi subjects, and the significance of their art for Sámi identity and culture. They lived and worked under cross pressure: the first few decades of the 20th century were characterized by racial theories that denigrated Sámi people, and the period following World War II was marked by demands for

  9. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population.

    Science.gov (United States)

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-03-01

    An international NGO, with financial and managerial support from "partner" communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala-an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access to referral care is facilitated. We conducted a mixed-methods study in San Sebastian Coatán municipality to assess the contribution of 2 Casas Maternas to health facility deliveries among partner and non-partner communities, with particular emphasis on equity in access. We surveyed all women who delivered in the study area between April 2013 and March 2014, the first full year in which both Casas Maternas in the study area were operating. In addition, using purposive sampling, we conducted in-depth interviews with 22 women who delivered and 6 focus group discussions with 42 community leaders, traditional birth attendants, and Casas Maternas staff members. We analyzed the quantitative data using descriptive statstics and the qualitative data with descriptive content analysis. Of the 321 women eligible for inclusion in the study, we surveyed 275 women (14.3% could not be located or refused to participate). Between April 2013 and March 2014, 70% of women living in partner communities delivered in a health facility (54% in a Casa Materna) compared with 30% of women living in non-partner communities (17% in a Casa Materna). There was no statistically significant difference in uptake of the Casa Materna by maternal education and only a weak effect by household wealth. In contrast, distance from the Casa Materna had a pronounced effect. Traditional birth attendants were strong advocates for utilization of the Casa Materna and played an important role in the decision regarding where the birth would take

  10. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population

    Science.gov (United States)

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-01-01

    ABSTRACT Background: An international NGO, with financial and managerial support from “partner” communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala—an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access to referral care is facilitated. Methods: We conducted a mixed-methods study in San Sebastian Coatán municipality to assess the contribution of 2 Casas Maternas to health facility deliveries among partner and non-partner communities, with particular emphasis on equity in access. We surveyed all women who delivered in the study area between April 2013 and March 2014, the first full year in which both Casas Maternas in the study area were operating. In addition, using purposive sampling, we conducted in-depth interviews with 22 women who delivered and 6 focus group discussions with 42 community leaders, traditional birth attendants, and Casas Maternas staff members. We analyzed the quantitative data using descriptive statstics and the qualitative data with descriptive content analysis. Results: Of the 321 women eligible for inclusion in the study, we surveyed 275 women (14.3% could not be located or refused to participate). Between April 2013 and March 2014, 70% of women living in partner communities delivered in a health facility (54% in a Casa Materna) compared with 30% of women living in non-partner communities (17% in a Casa Materna). There was no statistically significant difference in uptake of the Casa Materna by maternal education and only a weak effect by household wealth. In contrast, distance from the Casa Materna had a pronounced effect. Traditional birth attendants were strong advocates for utilization of the Casa Materna and played an important role in the

  11. Diáspora, duelo y memoria en Mi hermano de Jamaica Kincaid

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    Lucía Stecher

    2011-05-01

    fi ca Mi hermano de la escritora caribeña residente en Estados Unidos Jamaica Kincaid. Se muestra cómo a nivel de sus contenidos manifiestos –y también de la construcción de sí misma que hace Kincaid en una serie de entrevistas– la narrativa de esta autora se diferencia de la producida por otros autores diaspóricos contemporáneos, sobre todo en su reticencia a comprometerse en proyectos colectivos de asociación transcultural. Sin embargo, una lectura detenida del trabajo de duelo representado por la escritura de Mi hermano muestra cómo el discurso autoconsciente de la narradora-protagonista es subvertido por la fragilidad y vulnerabilidad a que la exponen la enfermedad y muerte de un ser querido.

  12. Testando o Modelo da Casa da Capacidade para o Trabalho entre profissionais do setor hospitalar

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    Maria Carmen Martinez

    Full Text Available RESUMO: Objetivo: Testar o Modelo da Casa da Capacidade para o Trabalho, verificando a hierarquia das dimensões propostas para um grupo de trabalhadores do setor hospitalar. Métodos: Estudo de coorte (2009-2011 conduzido com 599 trabalhadores de um hospital na cidade de São Paulo. Foi usado um formulário com questões sobre dados sociodemográficos, estilo de vida e condições de trabalho, e as versões brasileiras da Escala Estresse no Trabalho, Desequilíbrio Esforço-Recompensa, Work-Related Activities That May Contribute To Job-Related Pain and/or Injury e Índice de Capacidade para o Trabalho (ICT. Foi realizada análise de regressão logística hierárquica: as variáveis independentes foram alocadas em níveis de acordo com as dimensões do modelo teórico para avaliar os fatores associados ao comprometimento da capacidade para o trabalho (CT. Resultados: As variáveis associadas ao comprometimento da CT em cada dimensão foram: (a dimensão sociodemográfica: idade < 30 anos (p = 0,20, (b dimensão saúde: história de acidente de trabalho (p = 0,029, (c dimensão competência profissional: baixo nível educacional (p = 0,008, (d dimensão valores: intensificação do excesso de comprometimento (< 0,001, e (e dimensão trabalho: intensificação do desequilíbrio esforço-recompensa (p = 0,009 e das demandas elevadas (p = 0,040. Conclusão: Os resultados do estudo confirmaram as dimensões propostas para o Modelo da Casa da Capacidade para o Trabalho, indicando que ele é válido como representação de um construto multidimensional de determinação multicausal, podendo ser utilizado na gestão da CT.

  13. Cuando dejan de ser bebés. una experiencia en la Casa Infantil Universitaria

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    González Corrales, Laura

    2007-04-01

    Full Text Available Resumen: En el presente artículo se realiza un análisis reflexivo acerca de los procesos experimentados por losniños y las niñas entre los dos y los tres años, en relación con los cambios continuos y progresivos en lasdiferentes áreas del desarrollo, a saber socioafectiva, cognitivo-lingüístico y psicomotriz. Asimismo, se da aconocer la experiencia obtenida como docentes de la Casa Infantil Universitaria de la Universidad de Costa Ricaen cuanto a las generalidades del desarrollo en esta edad. Las particularidades presentadas por la poblacióninfantil que asiste a la institución, así como las estrategias seguidas para su atención. Se hace referencia a laexperiencia lograda durante el período del II Ciclo 2005 y el I Ciclo 2006, el cual constituyó una excelenteoportunidad para favorecer el desarrollo integral de las personas de esas edades y el crecimiento profesional ypersonal de las maestras de la Casa Infantil Universitaria. Finalmente, se brindan algunas estrategias yconsideraciones finales sobre cómo conducir y guiar a los niños y las niñas de esta edad en ambientes noescolarizados.Abstract: The next article is intended to make a reflexive analysis about the procedures experimented by the littleboys and girls between ages two to five years old, related to the continuous and progressive changes in thedifferent areas of the development, such as the socio/affective area, the cognitive/linguistic area and thepsychomotor area. Therefore, it is set to cheer the experience obtained as teachers of the Children’s UniversityHouse from The Costa Rican University as far as the generalities of the development in these age range, theparticularities presented by the children that attend this institution, as well as the strategies that were followed totake care of this population. Is focused mainly to the experience achieved among the 2005 II semester and 2006 Isemester periods, that was an excellent opportunity to favor the integral

  14. Why nobody likes a prophet: Bartolomé de las Casas, a loud voice in the wilderness

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    Lawrence A. Clayton

    2016-12-01

    Full Text Available This essay focuses on and analyzes the role of prophet that Bartolomé de las Casas (1485–1566 lived out in the conquest and settlement of the New World. Borrowing a great deal from a shorter essay written years ago by Stafford Poole on the history and nature of prophets, we examine how Las Casas’s life mirrored so many of the qualities and characteristics of the prophet, especially those of the Old Testament. It is part of our general argument that one can only truly understand the life of Las Casas, often described as the greatest defender of American Indians (the “indigenous” in today’s jargon, by placing him squarely within the Scriptural prophetic tradition that drove both is thinking and his actions. This is a “Critical Essay” and it was originally delivered as a public lecture.

  15. Experimentando cuidados en el contexto de una casa de partos: visión de las pacientes

    OpenAIRE

    GONÇALVES, Roselane; AGUIAR, Cláudia de Azevedo; MERIGHI, Miriam Aparecida Barbosa; JESUS, Maria Cristina Pinto de

    2011-01-01

    O modelo de assistência ao parto e nascimento no Brasil tem sido tema de muitas discussões e estudos sobre a incorporação de práticas obstétricas que considerem a autonomia da mulher no processo de parturição. O modelo proposto pelas Casas de Parto configura-se como um cenário para esses cuidados. Este estudo voltou-se para a compreensão da vivência da mulher parturiente no contexto de uma Casa de Parto situada em São Paulo. Os dados foram coletados no período de março a outubro de 2007 e ana...

  16. Unicidade: Proposta para uma cidadania ativa no espaço urbano aumentado do bairro de Casa Amarela

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    Madyana Torres

    2015-10-01

    Full Text Available Urban public spaces reflect changes in socioeconomic and political structures of a population. Concepts such as Augmented City reveal how this space is currently being progressively transformed and measured, as well as the growth of its importance. Given this context, this study investigates how to stimulate the feeling of protection and familiarity and how the designer can handle the complexity of this scenario. To that end, a project was proposed for the Casa Amarela neighbourhood, in Recife. Focusing on how to stimulate the engagement of the current group of residents to the collective Casa Amarela Saudável e Sustentável, techniques of Participatory Design were used for research, ideation and project development.

  17. Minha casa, minha vida: extensão do direito à moradia e proteção constitucional

    OpenAIRE

    Guilherme Domingos de Luca; Teófilo Marcelo de Arêa Leão Júnior

    2016-01-01

    O trabalho em questão busca analisar o Direito à moradia sob a ótica do Programa “Minha Casa, Minha Vida”. Demonstrará as ações do Estado visando a Regularização Fundiária, em face do interesse social no combate ao déficit imobiliário, além de analisar as hipóteses de perda do imóvel. O objetivo geral do estudo é compreender se há efetividade no direito à moradia a partir da vinculação ao Programa “Minha Casa, Minha Vida”, instituído pelo advento da Lei n° 11.977/09. De forma específica, o ob...

  18. Fray Bartolomé de Las Casas in the Work and Thought of Fray Servando Teresa de Mier

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    Begoña Pulido Herráez

    2011-10-01

    Full Text Available This paper studies the presence and influence of fray Bartolomé de Las Casas’s thought on the work of fray Servando Teresa de Mier, particularly the way in which it influenced the shaping of his original idea of the existence of a pact, a set of fundamental laws, a constitution established in the years after the conquest and where America would be included in the Crown of Castile as an independent realm, and not a colony. We examine the different texts where Mier starts to appropriate Las Casas’s thought, especially two poorly known texts: the Speech of Doctor Don Servando de Mier, born in Mexico, confirming the apology of Bishop Casas, written by the Reverend Bishop of Blois, Monsignor Henrique Gregoire, in a letter written in the year 1806, and the prologue to the edition of A Short Account of the Destruction of the Indies by Bartolomé de las Casas.

  19. Casas Maternas in the Rural Highlands of Guatemala: A Mixed-Methods Case Study of the Introduction and Utilization of Birthing Facilities by an Indigenous Population

    OpenAIRE

    Stollak, Ira; Valdez, Mario; Rivas, Karin; Perry, Henry

    2016-01-01

    ABSTRACT Background: An international NGO, with financial and managerial support from ?partner? communities, established Casas Maternas (birthing facilities) in 3 municipalities in the isolated northwestern highlands of the department of Huehuetenango in Guatemala?an area with high maternal mortality ratio (338 maternal deaths per 100,000 live births). Traditional birth attendants are encouraged to bring patients for delivery at the Casas Maternas, where trained staff are present and access t...

  20. Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants.

    Science.gov (United States)

    Posner, Kelly; Oquendo, Maria A; Gould, Madelyn; Stanley, Barbara; Davies, Mark

    2007-07-01

    To evaluate the link between antidepressants and suicidal behavior and ideation (suicidality) in youth, adverse events from pediatric clinical trials were classified in order to identify suicidal events. The authors describe the Columbia Classification Algorithm for Suicide Assessment (C-CASA), a standardized suicidal rating system that provided data for the pediatric suicidal risk analysis of antidepressants conducted by the Food and Drug Administration (FDA). Adverse events (N=427) from 25 pediatric antidepressant clinical trials were systematically identified by pharmaceutical companies. Randomly assigned adverse events were evaluated by three of nine independent expert suicidologists using the Columbia classification algorithm. Reliability of the C-CASA ratings and agreement with pharmaceutical company classification were estimated. Twenty-six new, possibly suicidal events (behavior and ideation) that were not originally identified by pharmaceutical companies were identified in the C-CASA, and 12 events originally labeled as suicidal by pharmaceutical companies were eliminated, which resulted in a total of 38 discrepant ratings. For the specific label of "suicide attempt," a relatively low level of agreement was observed between the C-CASA and pharmaceutical company ratings, with the C-CASA reporting a 50% reduction in ratings. Thus, although the C-CASA resulted in the identification of more suicidal events overall, fewer events were classified as suicide attempts. Additionally, the C-CASA ratings were highly reliable (intraclass correlation coefficient [ICC]=0.89). Utilizing a methodical, anchored approach to categorizing suicidality provides an accurate and comprehensive identification of suicidal events. The FDA's audit of the C-CASA demonstrated excellent transportability of this approach. The Columbia algorithm was used to classify suicidal adverse events in the recent FDA adult antidepressant safety analyses and has also been mandated to be applied to all

  1. A support vector machine and a random forest classifier indicates a 15-miRNA set related to osteosarcoma recurrence

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    He Y

    2018-01-01

    Full Text Available Yunfei He,1,2,* Jun Ma,1,* An Wang,1,3,* Weiheng Wang,1 Shengchang Luo,1 Yaoming Liu,2 Xiaojian Ye1 1Department of Orthopaedics, Changzheng Hospital Affiliated with Second Military Medical University, Shanghai, 2Department of Orthopaedics, Lanzhou General Hospital of Lanzhou Military Command Region, Lanzhou, 3Department of Orthopaedics, Shanghai Armed Police Force Hospital, Shanghai, People’s Republic of China *These authors contributed equally to this work Background: Osteosarcoma, which originates in the mesenchymal tissue, is the prevalent primary solid malignancy of the bone. It is of great importance to explore the mechanisms of metastasis and recurrence, which are two primary reasons accounting for the high death rate in osteosarcoma. Data and methods: Three miRNA expression profiles related to osteosarcoma were downloaded from GEO DataSets. Differentially expressed miRNAs (DEmiRs were screened using MetaDE.ES of the MetaDE package. A support vector machine (SVM classifier was constructed using optimal miRNAs, and its prediction efficiency for recurrence was detected in independent datasets. Finally, a co-expression network was constructed based on the DEmiRs and their target genes. Results: In total, 78 significantly DEmiRs were screened. The SVM classifier constructed by 15 miRNAs could accurately classify 58 samples in 65 samples (89.2% in the GSE39040 database, which was validated in another two databases, GSE39052 (84.62%, 22/26 and GSE79181 (91.3%, 21/23. Cox regression showed that four miRNAs, including hsa-miR-10b, hsa-miR-1227, hsa-miR-146b-3p, and hsa-miR-873, significantly correlated with tumor recurrence time. There were 137, 147, 145, and 77 target genes of the above four miRNAs, respectively, which were assigned to 17 gene ontology functionally annotated terms and 14 Kyoto Encyclopedia of Genes and Genomes pathways. Among them, the “Osteoclast differentiation” pathway contained a total of seven target genes and was

  2. miR482 and Its Isoforms in Plants

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    Abdil Hakan EREN

    2016-09-01

    Full Text Available In plants, miR482 family members are generally 22-nucleotide long, distinguishing from other microRNA (miRNA families by their extraordinary and diverse sequence structures. Studies showed that miRNA482 is related to NBLRR (Nucleotide binding-site leucine-rich repeat genes conferring resistance to disease in plants. There are different coded NB-LRR genes which are considered as the part immune response assisting the recognition of pathogens in plant genomes. NB-LRR proteins are mostly related to effector – triggering immune system against pathogens. The main immune receptors in plants are PRR (Pattern recoginition receptor and R (Resistance proteins. R proteins code for immune system proteins by NB-LRR activity. miR482, miR1448, slmiR2118 and ath-miR472 are disease resistance related miRNAs. In several studies, miR482 was found to be a homolog of miR1448 and phylogenetic analyses showed that miR1448 is formed by tandem duplication of miR482. While suppression of miR482 results in plant susceptibility to pathogens, miR482 was considered to play role in nodulation and mycorrhizal processes of soya roots. Increasing evidences exhibit that miR482 is critical in disease resistance against pathogen attacks.

  3. MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.

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    Kun Wang

    2014-07-01

    Full Text Available Long noncoding RNAs (lncRNAs are emerging as new players in gene regulation, but whether lncRNAs operate in the processing of miRNA primary transcript is unclear. Also, whether lncRNAs are involved in the regulation of the mitochondrial network remains to be elucidated. Here, we report that a long noncoding RNA, named mitochondrial dynamic related lncRNA (MDRL, affects the processing of miR-484 primary transcript in nucleus and regulates the mitochondrial network by targeting miR-361 and miR-484. The results showed that miR-361 that predominantly located in nucleus can directly bind to primary transcript of miR-484 (pri-miR-484 and prevent its processing by Drosha into pre-miR-484. miR-361 is able to regulate mitochondrial fission and apoptosis by regulating miR-484 levels. In exploring the underlying molecular mechanism by which miR-361 is regulated, we identified MDRL and demonstrated that it could directly bind to miR-361 and downregulate its expression levels, which promotes the processing of pri-miR-484. MDRL inhibits mitochondrial fission and apoptosis by downregulating miR-361, which in turn relieves inhibition of miR-484 processing by miR-361. Our present study reveals a novel regulating model of mitochondrial fission program which is composed of MDRL, miR-361 and miR-484. Our work not only expands the function of the lncRNA pathway in gene regulation but also establishes a new mechanism for controlling miRNA expression.

  4. Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.

    Science.gov (United States)

    Isozaki, K.; Tsujimura, T.; Nomura, S.; Morii, E.; Koshimizu, U.; Nishimune, Y.; Kitamura, Y.

    1994-01-01

    The mi locus of mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called mi factor). In addition to microphthalmus, osteopetrosis, and lack of melanocytes, mice of mi/mi genotype are deficient in mast cells. Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit. However, it remained to be examined whether the c-kit expression was also deficient in tissues of mi/mi mice. In the present study, we examined the c-kit expression by mi/mi skin mast cells using in situ hybridization and immunohistochemistry. Moreover, we examined the c-kit expression by various cells other than mast cells in tissues of mi/mi mice. We found that the c-kit expression was deficient in mast cells but not in erythroid precursors, testicular germ cells, and neurons of mi/mi mice. This suggested that the regulation of the c-kit transcription by the mi factor was dependent on cell types. Mice of mi/mi genotype appeared to be a useful model to analyze the function of transcription factors in the whole-animal level. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:7524330

  5. Quality, height, age and home advantage in boxing. [Calidad, altura, edad y la ventaja de boxear en casa].

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    Miguel Pic

    2018-04-01

    Full Text Available Abstract The main objective of the present study was the identification of performance indicators in boxing and their impact on the concept of home advantage (HA, among other variables. Professional boxing bouts of the European ranking were selected (N = 522, to generate 1044 units of analysis. ANOVA and T-student analyzes were applied to determine the influence of the difference between boxers in: a quality, calculated by the number of combats won, opponent's quality, inactivity time, among other indicators; b height and c age, depending on the result obtained and the location of the combat. It was also used as an influential variable in the final result. By multivariate analysis (CHAID model, the quality difference between boxers was the most determinant variable (p <.000 to reach the final result, but it was also predictive regarding the combat location (p <.006. The study allowed for revealing determinant effects for the performance in boxing through the crossing of variables and analysis techniques. Suggesting coaches and boxing practitioners to do a thorough review of their training tasks based on the location of their commitments and the boxers’ characteristics means they would profit the specificity of each match. The calculation of the risk percentage assumed by professional boxers to achieve success in professional boxing, is one of the practical applications of this research. Resumen El objetivo principal del presente estudio fue la identificación de indicadores de rendimiento en boxeo y su incidencia sobre el concepto de ventaja de jugar en casa (HA, entre otras variables. Fueron seleccionados combates profesionales del ranking Europeo (N=522 dando lugar a 1044 unidades de análisis. Fueron aplicados análisis ANOVA y T-student para determinar la influencia de la diferencia entre boxeadores en: a calidad, calculada mediante el número de combates ganados, calidad del oponente, tiempo de inactividad, entre otros indicadores; b

  6. Estudo da prevalência das doenças tireoidianas em pacientes tireoidectomizados no Hospital da Santa Casa de Goiânia

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    Alexandre Roberti

    Full Text Available OBJETIVO: O Estado de Goiás deixou de ser oficialmente considerado como região endêmica de bócio em 1995. O objetivo deste estudo é verificar a correspondência entre os diagnósticos das doenças tireoidianas (bócio endêmico, tireoidites e câncer, observados nos laudos anátomo-patológicos e nas observações dos inquéritos epidemiológicos. MÉTODO: Estudo retrospectivo de 1399 pacientes submetidos a tireoidectomias na Santa Casa de Misericórdia de Goiânia de 1993 a 2003, e que resultaram em 1610 diagnósticos anátomo-patológicos. RESULTADOS: Os resultados dos exames anátomo-patológicos dos pacientes revelaram: a adenoma folicular 155 (9,63%; b outros adenomas 29 (1,8%; c bócio adenomatoso 87 (5,4%; d bócio colóide 981 (60,9%; e carcinoma folicular 36 (2,24%; f carcinoma indiferenciado 3 (0,19%; g carcinoma papilífero 93 (5,78%; h cistos 9 (0,56%; i bócio difuso tóxico 75 (4,66%; j outras tireoidites 12 (0,75%; l outras neoplasias malignas 6 (0,38% e m tireoidite linfocítica 124 (7,71%. CONCLUSÕES: O perfil observado com uma prevalência alta de tireoidite linfocítica e carcinoma papilífero se correlaciona realmente com região não endêmica.

  7. Tutoria com médicos residentes em anestesiologia: o programa da Irmandade da Santa Casa de Misericórdia de São Paulo

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    Marcolino José Álvaro Marques

    2004-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A residência médica pode trazer desgaste emocional. Este artigo descreve um programa de tutoria durante o período de treinamento dos médicos em Anestesiologia. MÉTODO: O programa foi instituído na Irmandade da Santa Casa de Misericórdia de São Paulo. Vinte e sete residentes de Anestesiologia participaram do programa e quatro profissionais de saúde constituíram a equipe de tutoria. Um questionário sobre as impressões dos médicos residentes de primeiro e segundo anos, a respeito da formação médica em Anestesiologia foi desenvolvido com doze perguntas e três respostas para cada um, sendo aplicado antes e no fim do programa. Foram constituídos quatro grupos de residentes: residentes do 1º ano; residentes do 2º ano; residentes do 1º ano e 2º ano (2 grupos. As reuniões de tutoria ocorreram mensalmente às quintas-feiras, 7h00, com duração de uma hora. RESULTADOS: O cotidiano do residente foi considerado adequado. Houve redução na frustração e melhoria na auto-confiança. Um número elevado descreveu maior entusiasmo pela Anestesiologia e expectativas mais elevadas em relação ao futuro após a residência. Os tutores relataram a importância de reuniões obrigatórias, a possibilidade discutir a humanização e a possibilidade de despreparo dos tutores como um fator da limitação. CONCLUSÕES: O programa de tutoria pode ser considerado como um instrumento para a adaptação dos residentes no programa de Anestesiologia.

  8. Cuerpo(s-espacio(s como objeto(s de intervención política. Lecturas críticas sobre el programa habitacional “Mi Casa, Mi Vida”

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    Pedro Lisdero

    2010-04-01

    Full Text Available Este libro presenta resultados de la investigación titulada “Subjetividades y contextos de pobreza. Deconstrucción de políticas habitacionales en el traslado de familias a nuevas ciudades-barrio de Córdoba”, dirigida por María Eugenia Boito y Ana Levstein.Desde nuestra interpretación, la amplitud de miradas recogidas en artículos individuales y colectivos, encuentra en la problematización de una política pública puntual un campo fructífero donde indagar ciertas relaciones entre sujeto-cuerpo y espacios, que devienen centrales para comprender los procesos de constitución social. La reseña se organiza en función de tres ejes: primero reunimos artículos que se ocupan de las lógicas de funcionamiento de un tipo de intervención estatal en el campo de la pobreza, que reconfigura no solo las posibilidades de movilidad, acción e interacción entre los cuerpos, sino que además afecta las constituciones subjetivas a partir de lo que inaugura la vivencia de la condición habitacional. Un segundo eje se traza alrededor de la indagación de la transformación en los regímenes de sensibilidad atados a la nueva condición habitacional. Finalmente se vincula el juego entre la operatoria del sueño observada por Scribano y la propuesta de recuperar la literalidad como clave de análisis crítico que señalan en su artículo Boito, Espoz e Ibáñez.

  9. Cuerpo(s-espacio(s como objeto(s de intervención política. Lecturas críticas sobre el programa habitacional “Mi Casa, Mi Vida”

    Directory of Open Access Journals (Sweden)

    Pedro Lisdero

    2010-04-01

    Full Text Available Este libro presenta resultados de la investigación titulada “Subjetividades y contextos de pobreza. Deconstrucción de políticas habitacionales en el traslado de familias a nuevas ciudades-barrio de Córdoba”, dirigida por María Eugenia Boito y Ana Levstein. Desde nuestra interpretación, la amplitud de miradas recogidas en artículos individuales y colectivos, encuentra en la problematización de una política pública puntual un campo fructífero donde indagar ciertas relaciones entre sujeto-cuerpo y espacios, que devienen centrales para comprender los procesos de constitución social. La reseña se organiza en función de tres ejes: primero reunimos artículos que se ocupan de las lógicas de funcionamiento de un tipo de intervención estatal en el campo de la pobreza, que reconfigura no solo las posibilidades de movilidad, acción e interacción entre los cuerpos, sino que además afecta las constituciones subjetivas a partir de lo que inaugura la vivencia de la condición habitacional. Un segundo eje se traza alrededor de la indagación de la transformación en los regímenes de sensibilidad atados a la nueva condición habitacional. Finalmente se vincula el juego entre la operatoria del sueño observada por Scribano y la propuesta de recuperar la literalidad como clave de análisis crítico que señalan en su artículo Boito, Espoz e Ibáñez. Fecha de recepción: 31 de marzo de 2010. Fecha de aceptación: 18 de abril de 2010.

  10. Estudo retrospectivo dos transplantes penetrantes de córnea da Santa Casa de Porto Alegre Retrospective study of penetrating keratoplasty at the Santa Casa of Porto Alegre

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    Caroline Fabris

    2001-10-01

    Full Text Available Objetivos: Traçar o perfil clínico e social dos pacientes submetidos a transplante de córnea e avaliar as principais indicações desses transplantes, tempo de espera para doação e os índices de sucesso, rejeição e falência dos transplantes penetrantes de córnea. Métodos: Foram analisados retrospectivamente os prontuários de 87 pacientes submetidos a transplante penetrante de córnea no Serviço de Oftalmologia da Santa Casa de Porto Alegre entre janeiro de 1990 e dezembro de 1998, totalizando 91 olhos. Destes, 56 pacientes foram chamados para avaliação clínica do enxerto durante o levantamento de dados para este estudo. Resultados: Considerando-se os 91 transplantes (87 pacientes, 53 (60,9% foram realizados em pacientes do sexo masculino e 34 (39%, do sexo feminino. A idade variou de 3 a 89 anos, com média de 42,3 ± 19,8 anos. As principais indicações para transplante de córnea foram ceratocone em 32 (35% olhos, ceratopatia bolhosa (pós-facectomia, distrofia de Fuchs e outros em 24 (26,4%, trauma mecânico em 9 (9,9%, causas infecciosas em 9 (9,9%, queimadura química em 2 (2,2%, queimadura térmica em 1 (1,1% e outras causas em 14 (15,4% olhos. O tempo médio de espera por doação de córnea foi de 17,3 ± 9,9 meses. Do total de 91 olhos transplantados, 25 (27,5% apresentaram rejeição e 12 (13,2% olhos apresentaram falência do transplante. Conclusões: Este estudo mostrou a epidemiologia dos pacientes transplantados. A falta de dados seriados devido à alta precoce e perda de acompanhamento dos pacientes tornou impossível a análise e a comparação dos resultados pós-operatórios com outros estudos.Purpose: To describe the clinical and social profile of recipient patients of transplanted corneas, and to evaluate main indications for corneal transplants, waiting time for donor tissue, and percentages of success, rejection and failure of penetrating keratoplasty. Methods: Retrospective chart review of 87 patients

  11. Relatório de Salvamento e Acompanhamento Arqueológico nas Obras de Restauro da Casa da Banha

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    Luciana Peixoto

    2012-09-01

    Full Text Available Este relatório  apresenta os resultados do trabalho de acompanhamento e salvamento arqueológico realizado pelo Instituto de Memória e Patrimônio em parceria com o Laboratório de Antropologia e Arqueologia da UFPEL no imóvel denominado Casa da Banha durante as obras de restauro executadas no ano de 2007. O imóvel localizado no entorno da Praça Coronel Pedro Osório, centro histórico de Pelotas, foi construído na década de 30 do século XIX e ao longo de sua história sediou diversas instituições, públicas e privadas, sendo conhecido até hoje pelo nome Casa da Banha, último estabelecimento comercial que ali se instalou na década de 60 do século XX.PALAVRAS-CHAVE: Arqueologia histórica, Patrimônio.ABSTRACT: This report presents results of the work Monitoring and Rescue Archaeological accomplished by Institute for Memory and Heritage in partnership with the Laboratory of Anthropology and Archaeology of UFPEL in the property called Casa da Banha the restoration  works carried out in 2007. The property located around of Praça Coronel Pedro Osório, the historic center of Pelotas, was built in the late 30th century Throughout its diverse history hosted institutions, public and private, being known today by the name  of the Casa da BAnha, last commercial establishment that settled there in the 60s of the XX Century.KEY-WORKS: Historical Archaeology, Heritage.

  12. Autoficción y trabajo de memoria en La casa de los conejos de Laura Alcoba

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    Bruno Ragazzi

    2014-02-01

    Full Text Available The article explores discursive representations within the field of memory in La casa de los conejos by Laura Alcoba. The choice of autofiction as a genre allows discovering new mnemic narratives around the unequal confrontation between Montoneros and right-wing repressive forces. These novel ways of viewing the past are connected to what Ricoeur has called “work of memory”, a therapeutic elaboration on memory that enables a community to reach hope and forgiveness.

  13. Content validity of CASA-Q cough domains and UCSD-SOBQ for use in patients with Idiopathic Pulmonary Fibrosis.

    Science.gov (United States)

    Gries, Katharine Suzanne; Esser, Dirk; Wiklund, Ingela

    2013-09-16

    The study objective was to assess the content validity of the Cough and Sputum Assessment Questionnaire (CASA-Q) cough domains and the UCSD Shortness of Breath Questionnaire (SOBQ) for use in patients with Idiopathic Pulmonary Fibrosis (IPF). Cross-sectional, qualitative study with cognitive interviews in patients with IPF. Study outcomes included relevance, comprehension of item meaning, understanding of the instructions, recall period, response options, and concept saturation. Interviews were conducted with 18 IPF patients. The mean age was 68.9 years (SD 11.9), 77.8% were male, and 88.9% were Caucasian. The intended meaning of the CASA-Q cough domain items was clearly understood by most of the participants (89-100%). All participants understood the CASA-Q instructions; the correct recall period was reported by 89% of the patients, and the response options were understood by 76%. The intended meaning of the UCSD-SOBQ items was relevant and clearly understood by all participants. Participants understood the instructions (83%) and all patients understood the response options (100%). The reported recall period varied based on the type of activity performed. No concepts were missing, suggesting that saturation was demonstrated for both measures. This study provides evidence for content validity for the CASA-Q cough domains and the UCSD-SOBQ for patients with IPF. Items of both questionnaires were understood and perceived as relevant to measure the key symptoms of IPF. The results of this study support the use of these instruments in IPF clinical trials as well as further studies of their psychometric properties.

  14. Characterization of the Merkel Cell Carcinoma miRNome

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    Matthew S. Ning

    2014-01-01

    Full Text Available MicroRNAs have been implicated in various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma; however, the expression of microRNAs and their role in Merkel cell carcinoma (MCC have yet to be explored in depth. To identify microRNAs specific to MCC (MCC-miRs, next-generation sequencing (NGS of small RNA libraries was performed on different tissue samples including MCCs, other cutaneous tumors, and normal skin. Comparison of the profiles identified several microRNAs upregulated and downregulated in MCC. For validation, their expression was measured via qRT-PCR in a larger group of MCC and in a comparison group of non-MCC cutaneous tumors and normal skin. Eight microRNAs were upregulated in MCC: miR-502-3p, miR-9, miR-7, miR-340, miR-182, miR-190b, miR-873, and miR-183. Three microRNAs were downregulated: miR-3170, miR-125b, and miR-374c. Many of these MCC-miRs, the miR-183/182/96a cistron in particular, have connections to tumorigenic pathways implicated in MCC pathogenesis. In situ hybridization confirmed that the highly expressed MCC-miR, miR-182, is localized within tumor cells. Furthermore, NGS and qRT-PCR reveal that several of these MCC-miRs are highly expressed in the patient-derived MCC cell line, MS-1. These data indicate that we have identified a set of MCC-miRs with important implications for MCC research.

  15. Perfil mediacional de mães sociais que atuam em instituições de acolhimento

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    Débora Nogueira Tomás

    Full Text Available Este artigo aborda as interações entre mãe social e criança em situação de acolhimento, em instituição tipo casa-lar, devido à importância de mediações adequadas para o desenvolvimento infantil. Participaram quatro mães sociais, responsáveis pelas crianças de até seis anos de idade. Foram feitas observações do cotidiano institucional, entrevistas semiestruturadas com as participantes e vídeo-gravações de momentos de interação durante atividades rotineiras, como banho e alimentação. Foram realizadas vinte filmagens de dez minutos cada, sendo cinco de cada mãe social. As filmagens foram transcritas e analisadas conforme os critérios mediacionais - focalização, expansão, mediação de significado, recompensa e regulação de comportamento, propostos na abordagem da aprendizagem mediada. Os dados mostraram que o critério mediacional mais utilizado pelas mães foi a regulação de comportamento, e o menos utilizado, a expansão. O trabalho discute a necessidade de um programa contínuo de formação para mães sociais, com ênfase nos comportamentos mediacionais.

  16. miReg: a resource for microRNA regulation

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    Barh Debmalya

    2010-03-01

    Full Text Available MicroRNAs (miRNAs/miRs are important cellular components that regulate gene expression at posttranscriptional level. Various upstream components regulate miR expression and any deregulation causes disease conditions. Therefore, understanding of miR regulatory network both at upstream and downstream level is crucial and a resource on this aspect will be helpful. Currently available miR databases are mostly related to downstream targets, sequences, or diseases. But as of now, no database is available that provides a complete picture of miR regulation in a specific condition.

  17. Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway.

    Science.gov (United States)

    Yin, Mengmeng; Yuan, Yin; Cui, Yurong; Hong, Xian; Luo, Hongyan; Hu, Xinwu; Tang, Ming; Hescheler, Jurgen; Xi, Jiaoya

    2015-01-01

    Puerarin shows a wide range of biological activities, including affecting the cardiac differentiation from murine embryonic stem (mES) cells. However, little is known about its effect and mechanism of action on the self-renewal of mES cells. This study aimed to determine the effect of puerarin on the self-renewal and pluripotency of mES cells and its underlying mechanisms. RT-PCR and real-time PCR were used to detect the transcripts of core transcription factors, specific markers for multiple lineages, REST and microRNA-21 (miR-21). Colony-forming assay was performed to estimate the self-renewal capacity of mES cells. Western blotting and wortmannin were employed to explore the role of PI3K/Akt signaling pathway in the inhibitory action of puerarin on REST transcript. Transfected mES cells with antagomir21 were used to confirm the role of miR-21 in the action of puerarin on cell self-renewal. Puerarin significantly decreased the percentage of the self-renewal colonies, and suppressed the transcripts of Oct4, Nanog, Sox2, c-Myc and REST. Besides, PECAM, NCAM and miR-21 were up-regulated both under the self-renewal conditions and at day 4 of differentiation. The PI3K inhibitor wortmannin successfully reversed the mRNA expression changes of REST, Nanog and Sox2. Transfection of antagomir21 efficiently reversed the effects of puerarin on mES cells self-renewal. Inhibition of REST-miR-21 regulatory pathway may be the key mechanism of puerarin-induced suppression of mES cells self-renewal.

  18. El corredor en la casa de campo. 15 casos entre el mar y la cordillera

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    Hernán Ascui Fernández

    2008-10-01

    Además de sus cualidades de resguardo al clima es un lugar para el descanso, el trabajo y la contemplación. Por su alta eficiencia funcional, el corredor es un ámbito esencial para la vida campesina que se ha ido perfeccionando a través del tiempo en base a la experiencia y los conocimientos enraizados en la cultura local.

  19. Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer

    DEFF Research Database (Denmark)

    Winther, Mette; Alsner, Jan; Tramm, Trine

    2015-01-01

    analyses identified miR-21 as an independent prognostic marker for DSS in EAC [HR 3.52 (95% CI 1.06-11.69)]. High miR-375 was not correlated with improved prognosis in either histology. However, Forest plots demonstrated that both miR-21 and miR-375 were of prognostic impact in ESCC. CONCLUSION...... chemotherapy were analyzed. Expression levels of miR-21 and miR-375 were quantified using Affymetrix GeneChip miRNA 1.0 Array. The Cox proportional hazards model was used to assess the correlation of miR-21 and miR-375 with disease-specific survival (DSS) and overall survival (OS). Forest plots were performed...... to evaluate the prognostic impact of miR-21 and miR-375 in the present study and previously published reports. RESULTS: In ESCC, patients with miR-21 expression levels above median showed a trend towards poorer DSS and OS. When dividing miR-21 expression by tertiles, high levels of miR-21 significantly...

  20. miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3.

    Science.gov (United States)

    Qiu, Yu-Ying; Zhang, Ying-Wei; Qian, Xiu-Fen; Bian, Tao

    2017-01-01

    Asthma is tightly related to the imbalance of Th1/Th2 cells, and Runx3 plays a pivotal role in the differentiation of T helper cells. The present study aimed to investigate dysregulated microRNAs that may target Runx3 in CD4 + T cells from asthmatic patients and reveal Runx3 function in Th1/Th2 balance regulation. We detected the levels of Th1- and Th2-related cytokines by ELISA and analyzed the differentiation marker gene of T helper cells by qRT-PCR. Results indicated that an imbalance of Th1/Th2 cells was present in our asthmatic subject. Runx3 expression was reduced in the CD4 + T cells from asthmatic patients. Overexpression of Runx3 could restore the Th1/Th2 balance. After performing microRNA microarray assay, we found a series of microRNAs that were considerably altered in the CD4 + T cells from asthmatic patients. Among these upregulated microRNAs, eight microRNAs that may target Runx3 were selected by bioinformatics prediction. Five microRNAs, namely miR-371, miR-138, miR-544, miR-145, and miR-214, were confirmed by qRT-PCR and selected as candidate microRNAs. Luciferase reporter assay showed that these five microRNAs could directly target the 3'-UTR of Runx3. However, only simultaneous inhibition of these five microRNAs could alter the expression of Runx3. Most importantly, only simultaneous inhibition could improve the Th1/Th2 balance. Thus, we suggest that miR-371, miR-138, miR-544, miR-145, and miR-214 can modulate the Th1/Th2 balance in asthma by regulating Runx3 in a combinatorial manner.

  1. STUDY REGARDING THE PERFORMANCE EVOLUTION OF „CASA DE LA ROSA” HOTEL

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    PÎRJOL FLORENTINA

    2015-12-01

    Full Text Available The main goal of an economic activity in tourism is the granting of the effective needs and the potential needs of its consumers. The accomodations present a growing interest regarding the quality level of the services, the variety and also the complexity off additional services, so that the tourists have impecable conditions for the whole duration of their stay. The performance of a hotel, mainly results, from the impression the tourist leaves with. Therefore, if the offered services, aswell as the staff attitude pleased the tourist, he will return to that place. In the presented paper, the performance evolution of „Casa de la Rosa” Hotel was analysed. This is a 3 star hotel, from Timisoara, Timis county. The analysis was made for a period of 5 years from 2010 to 2014. For this purpose, I asked the hotel manager, Mr. Laurentiu ONEA, information regarding the „checking-in”, the medium stay, and the percentage of the foreign tourists as well as the Romanian tourists. This data was then used to calculate the indicators , required to the analisys. From a financialy-economical point of view analisys, data from the hotels internal sources were used regarding the turnover, profit and debts. The analisys showed a significant yearly growth of the hotels performances, mainly in the last 3 years of the analised period.

  2. Language’s Configurations in La casa de los conejos by Laura Alcoba

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    Estefanía Luján Di Meglio

    2018-01-01

    Full Text Available This article studies a novel written in the argentinean posdictatorship, in French, La casa de los conejos (2007 by Laura Alcoba. The main concept of the paper is the mother and second tongue and its multiples links with the history –the history of state violence– that novel relates. First of all, it is studied the fact that text is written in French in spite of author’s mother tongue is Spanish: Alcoba had to go into exile during the period of the “Triple A” in Argentina. In second place, it is observed that beyond this fact, there are several words written in Spanish. Such words work as metonymy of a whole language (Spanish, as a symbol of a history (the state terrorism and at the same time, they work as a metonymy of posdictatorship argentinean literature: those words represent the capital fact to telling a history in another way of that one of the oficial history.

  3. Simulation of Net Primary Productivity in Mongolia Using CASA Model, During 2000-2004

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    Narangarav Dugarsuren

    2016-12-01

    Full Text Available Vegetation net primary productivity (NPP is always used as an indicator of carbon cycling in terrestrial ecosystems at landscape and regional scales. Based on the CASA model, we analyzed the spatiotemporal pattern of growing season NPP from 2000 to 2004 using MODIS/NDVI and its relationship with precipitation. The result shows that the annual NPP in Mongolia has a tendency to slightly decrease from 61.13 in 2000 to 60 gC/m2 /yr in 2004, with an annual mean decrement of -0.259 gC/ m2 /yr. However, annual and inter-annual NPP trends showed spatial and temporal heterogeneity. NPP in forest and grassland has decreased with an average annual decrement of -1.03 (r2=0.262 and -0.49 (r2=0.324, meanwhile NPP in desert steppe and desert has increased with the annual average increment of 0.4327 (r2=0.322 and 0.2401 (r2=0.283, respectively. The correlation coeffi cient showed that mean growing season NPP in grassland and desert steppe were closely correlated with precipitation than forest and desert.

  4. "Eu quero uma casa no campo": a busca do verde em Belo Horizonte, 1966-1976

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    Regina Horta Duarte

    Full Text Available A expansão de condomínios horizontais esteve diretamente relacionada às condições históricas que acarretaram a deterioração e o abandono do centro urbano de Belo Horizonte, entre meados das décadas de 1960 e 1970. Nesse contexto, alguns tiveram o privilégio de escolher o sonho da casa no campo, atraídos por promessas de uma vida renovada, mergulhados nos paradoxos do desenvolvimento e dos dramas sociais, políticos e ambientais em curso no Brasil durante a ditadura civil-militar. Cientistas e técnicos realizavam as primeiras avaliações dos dilemas da poluição ambiental urbana. Entretanto, temas ambientais se configuravam como assunto extemporâneo e distante da política, subestimados por setores brasileiros de direita e esquerda. A perda de qualidade de vida em Belo Horizonte recebeu soluções individuais, por vezes com aspectos comunitários. O caráter simultâneo desses processos na capital mineira esclarece casos históricos similares em outras grandes metrópoles brasileiras e latino-americanas.

  5. Una finestra sul passato: Irse de casa di Carmen Martín Gaite

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    Giulia Tosolini

    2015-01-01

    Full Text Available Beyond historical and social implications, migration represents the possibility of crossing a threshold and opening oneself up to new empirical and emotional spaces. Amparo, the main character of Carmen Martín Gaite’s Irse de casa (1998, is the perfect personification of the gaitian feminine canon. After leaving Spain and settling in New York, she became a successful fashion designer, and seemed happy and easy-going. The bond with memory and the past is the main topic of this novel, as it is in most of Martín Gaite’s production. The window on the past that Amparo closed moving to the US suddenly reappears when she needs to discover herself and her origins. This inconvenience in an anonymous life brings huge changes that will condition her and her loved ones. Travelling to Spain and interacting with places and people connected with her childhood, Amparo goes through the window she had closed forty years before, restoring the order. The window connects the present and the past, symbolizes the emigrant’s transience, personified in the novel by Amparo, who can definitely find the lost serenity and heart’s-ease.

  6. Breath of fresh air; CASA's stakeholder approach has the glow of success

    International Nuclear Information System (INIS)

    Budd, G.

    2005-01-01

    The Clean Air Strategic Alliance (CASA), a stakeholder group of government, industry and officials from non-profit environmental groups, reports having achieved its target of 70 per cent reduction in flaring. The target was set in the late 1990s, and was reached in 2004. Environmentalists with public interest groups were particularly pleased, noting that methane, the main constituent of solution gas, is 23 times more potent in its greenhouse effect than carbon dioxide. Recent regulatory changes in sour gas management should reduce sulphur dioxide emissions as well, partly because a previous requirement for recovery of 96 per cent sulphur has been replaced by a 98.5 per cent sulphur recovery requirement. Despite these dramatic reductions in flaring, concerns continue to exist, as evidenced by a recent report about barriers that stand in the way of some further improvements, preventing upstream oil and gas companies from investing in emission-reducing and other environmental technologies. To reduce the barriers, the report advocates more and bigger tax incentives for environmental innovations, as well as direct funding during the demonstration phase of technology commercialization

  7. NEW HUMAN SEMEN ANALYSIS SYSTEM (CASA USING MICROSCOPIC IMAGE PROCESSING TECHNIQUES

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    N M Chaudhari

    2016-11-01

    Full Text Available Computer assisted semen analysis (CASA helps the pathologist or fertility specialist to evaluate the human semen. Detail analysis of spermatozoa like morphology and motility is very important in the process of intrauterine insemination (IUI or In-vitro fertilization (IVF in infertile couple. The main objective for this new semen analysis is to provide a low cost solution to the pathologist and gynecologist for the routine raw semen analysis, finding the concentration of the semen with dynamic background removal and classify the spermatozoa type (grade according to the motility and structural abnormality as per the WHO criteria. In this paper a new system , computer assisted semen analysis system is proposed in which hybrid approach is used to identify the moving object, scan line algorithm is applied for confirmation of the objects having tails, so that we can count the actual number of spermatozoa. For removal of background initially the dynamic background generation algorithm is proposed to create a background for background subtraction stage. The standard data set is created with 40× and 100× magnification from the different raw semen s. For testing the efficiency of proposed algorithm, same frames are applied to the existing algorithm. Another module of the system is focused on finding the motility and Type classification of individual spermatozoa.

  8. From Rhetoric to Interculturality. Some reflections on the contributions of Bartolomé de las Casas

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    Lorena Zuchel

    2018-01-01

    Full Text Available Writing in favor of the rhetoric, Las Casas was actually searching for a new anthropological model that would be different both from the elite humanism and from the Erasmian voluntarism. We would like to emphasize this attitude in the light of Las Casas’ practical objectives, which is to prevent from further homicide and to guarantee an unconditioned freedom to the Indians in every aspect of their social life. We will refer to this revolutionary attitude which is based on the theories of Aristotle and St. Thomas, but is also capable of overshadowing them in defense of the humanity itself and human values. The most important point of Las Casas’ theory is the recognition of the right and ability of every community to have an autonomous way of governing. For that reason, we argue, his writings can be interpreted as an important contribution to the question of the recognition of the Other, and as the theoretical starting point for the intercultural philosophy as well.

  9. San Pedro Atlapulco and the Real Casa de Moneda: Vicissitudes of a Community Enterprise

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    Felipe Castro Gutiérrez

    2008-01-01

    Full Text Available This work suggests the existence of very interesting exceptions to the widespread idea that New Spain indians were farmers who produced basically for their own needs and for paying tribute, thus limiting their contacts with the market. The author  examines the case of Atlapulco, a town that very soon became the main provider of charcoal as fuel for the official mint, the Real Casa de Moneda in Mexico City. The research reveals Atlapulco’s constant  battle against the arrival of indian and Spanish competitors seeking a sha­re in the deal, suggesting that the main reason for this attitude was the preservation of a lucrative monopoly, considered a special pri­vilege granted by the king. The author also describes the disputes between Atlapulco  and the mint administrators over fixing con­ tractually the price of charcoal. Finally, he examines the discourse used by Indians in the defense of their interests, pointing out how they appealed to the idea that commercial arrangements must ne­cessarilly take into account tradition, historical rights and mutual obligations sustaining social order.

  10. Trabalho de casa, auto-eficácia e rendimento em matemática

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    Pedro Sales Luís Rosário

    Full Text Available O Trabalho de Casa (TPC é uma estratégia instrutiva amplamente utilizada na Escola de muitos países. O TPC é um processo complexo que é afectado por múltiplos factores de ordem cognitiva, motivacional, social e contextual. A investigação tem-se centrado no tempo despendido na realização das tarefas de TPC, no entanto os resultados de vários estudos e as críticas metodológicas sugerem a necessidade de direccionar a pesquisa para outras variáveis. O objectivo deste estudo é a análise do poder preditivo da auto-eficácia percebida na Matemática e de três dimensões menos exploradas na literatura do TPC (e.g., número de TPC prescritos, taxa de completamento, e correcção percebida do TPC sobre o rendimento a matemática, em alunos portugueses do 5.º e 6.º ano de escolaridade (10 e 11 anos. Os resultados sugerem que o rendimento a matemática se encontra explicado, positiva e significativamente, pelas variáveis escolhidas. As conclusões sugerem a urgência de repensar o TPC como ferramenta educativa promotora do sucesso académico.

  11. Histórias de vida: as parteiras tradicionais e o nascimento em casa

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    Maria Djair Dias

    2007-08-01

    Full Text Available Esta é uma pesquisa qualitativa que utilizou a História Oral como caminho para investigar o fenômeno do nascimento em casa. Trata-se de compreender o significado da experiência de cuidar da mulher durante o processo de nascimento em domicilio em uma comunidade rural nordestina, a partir da história oral de vida das parteiras tradicionais. Os resultados revelam que a história de vida dessas mulheres se inscreve em um saber milenar que ao longo do tempo oferece significativa contribuição para a construção de um novo olhar em busca da humanização das relações no contexto da saúde, embora muito desse saber tenha sido desconsiderado com a institucionalização do cuidado. Diante da diversidade do universo cultural que envolve esse saber, considerado uma prática de solidariedade, um dom de Deus, conhecer e respeitar é condição fundamental para uma aproximação real entre o saber popular e o saber cientifico.

  12. A path-based measurement for human miRNA functional similarities using miRNA-disease associations

    Science.gov (United States)

    Ding, Pingjian; Luo, Jiawei; Xiao, Qiu; Chen, Xiangtao

    2016-09-01

    Compared with the sequence and expression similarity, miRNA functional similarity is so important for biology researches and many applications such as miRNA clustering, miRNA function prediction, miRNA synergism identification and disease miRNA prioritization. However, the existing methods always utilized the predicted miRNA target which has high false positive and false negative to calculate the miRNA functional similarity. Meanwhile, it is difficult to achieve high reliability of miRNA functional similarity with miRNA-disease associations. Therefore, it is increasingly needed to improve the measurement of miRNA functional similarity. In this study, we develop a novel path-based calculation method of miRNA functional similarity based on miRNA-disease associations, called MFSP. Compared with other methods, our method obtains higher average functional similarity of intra-family and intra-cluster selected groups. Meanwhile, the lower average functional similarity of inter-family and inter-cluster miRNA pair is obtained. In addition, the smaller p-value is achieved, while applying Wilcoxon rank-sum test and Kruskal-Wallis test to different miRNA groups. The relationship between miRNA functional similarity and other information sources is exhibited. Furthermore, the constructed miRNA functional network based on MFSP is a scale-free and small-world network. Moreover, the higher AUC for miRNA-disease prediction indicates the ability of MFSP uncovering miRNA functional similarity.

  13. "Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity.

    Directory of Open Access Journals (Sweden)

    Thomas Bertero

    Full Text Available Specificity of interaction between a microRNA (miRNA and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and hypoxia, respectively, induce very similar cellular effects in term of proliferation, migration and apoptosis. Hsa-miR-147b only shares a "minimal" 6-nucleotides seed sequence with hsa-miR-210, but is identical with hsa-miR-147a over 20 nucleotides, except for one base located in the seed region. Phenotypic changes induced after heterologous expression of miR-147a strikingly differ from those induced by miR-147b or miR-210. In particular, miR-147a behaves as a potent inhibitor of cell proliferation and migration. These data fit well with the gene expression profiles observed for miR-147b and miR-210, which are very similar, and the gene expression profile of miR-147a, which is distinct from the two others. Bioinformatics analysis of all human miRNA sequences indicates multiple cases of miRNAs from distinct families exhibiting the same kind of similarity that would need to be further characterized in terms of putative functional redundancy. Besides, it implies that functional impact of some miRNAs can be masked by robust expression of miRNAs belonging to distinct families.

  14. miRNAs in Alzheimer Disease - A Therapeutic Perspective.

    Science.gov (United States)

    Gupta, Priya; Bhattacharjee, Surajit; Sharma, Ashish Ranjan; Sharma, Garima; Lee, Sang-Soo; Chakraborty, Chiranjib

    2017-01-01

    Alzheimer's disease is a neurodegenerative disorder which generally affects people who are more than 60 years of age. The disease is clinically characterised by dementia, loss of cognitive functions and massive neurodegeneration. The presence of neurofibrilary tangles and amyloid plaques in the hippocampal region of the brain are the hallmarks of the disease. Current therapeutic approaches for the treatment of Alzheimer's disease are symptomatic and disease modifying, none of which provide any permanent solution or cure for the disease. Dysregulation of miRNAs is one of the major causes of neurodegeneration. In the present review, the roles of different miRNAs such as miR-9, miR-107, miR-29, miR-34, miR-181, miR-106, miR-146a, miR132, miR124a, miR153 has been discussed in detail in the pathogenesis of various neurodegenerative diseases with special focus on AD. The probability of miRNAs as an alternative and more sensitive approach for detection and management of the AD has also been discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  15. UTILIZATION OF 5Es' CONSTRUCTIVIST APPROACH FOR ...

    African Journals Online (AJOL)

    Global Journal

    learning, the effective utilization of which can enhance biology teaching and learning. This paper focused on how ... KEYWORDS: Utilization, 5Es Constructivist approach, difficult concepts, Biology. ... gives hope to the development of the deep.

  16. University of Dar es Salaam Library Journal

    African Journals Online (AJOL)

    University of Dar es Salaam Library Journal. ... PROMOTING ACCESS TO AFRICAN RESEARCH ... These include organization and dissemination of information, library education and training, information technology and its application in ...

  17. miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments

    Science.gov (United States)

    Hackenberg, Michael; Rodríguez-Ezpeleta, Naiara; Aransay, Ana M.

    2011-01-01

    We present a new version of miRanalyzer, a web server and stand-alone tool for the detection of known and prediction of new microRNAs in high-throughput sequencing experiments. The new version has been notably improved regarding speed, scope and available features. Alignments are now based on the ultrafast short-read aligner Bowtie (granting also colour space support, allowing mismatches and improving speed) and 31 genomes, including 6 plant genomes, can now be analysed (previous version contained only 7). Differences between plant and animal microRNAs have been taken into account for the prediction models and differential expression of both, known and predicted microRNAs, between two conditions can be calculated. Additionally, consensus sequences of predicted mature and precursor microRNAs can be obtained from multiple samples, which increases the reliability of the predicted microRNAs. Finally, a stand-alone version of the miRanalyzer that is based on a local and easily customized database is also available; this allows the user to have more control on certain parameters as well as to use specific data such as unpublished assemblies or other libraries that are not available in the web server. miRanalyzer is available at http://bioinfo2.ugr.es/miRanalyzer/miRanalyzer.php. PMID:21515631

  18. Género y trabajo: experiencia de las prestadoras de las casas de salud de mujeres indígenas de Guerrero y Oaxaca Gender and work: the experience of providers of health services to indigenous women from Guerrero and Oaxaca

    Directory of Open Access Journals (Sweden)

    Claudia Isabel Amaya-Castellanos

    2012-03-01

    Full Text Available OBJETIVO: Identificar, a través del discurso de prestadoras de servicio de las Casas de Salud de las Mujeres Indígenas de México en Ometepec, Guerrero y Matías Romero, Oaxaca, el papel de género en el desempeño de su rol como trabajadoras. METODOLOGÍA: Estudio cualitativo, basado en un análisis secundario de las entrevistas realizadas como parte del proyecto "Rescatando la experiencia de la Casa de la Mujer Indígena: sistematización y evaluación del proceso". RESULTADOS: Se identificó un importante valor al trabajo y compromiso hacia la comunidad. La culpa aparece como producto de la tensión entre el trabajo fuera del hogar y las responsabilidades como madres y esposas. La posibilidad de ayudar a otras mujeres es fuente de gratificación que disipa estos conflictos; el prestigio y el reconocimiento se suman a las ganancias de su rol. CONCLUSIONES: La experiencia laboral de las mujeres trabajadoras en la "casa de la mujer indígena" de Matías Romero, Oaxaca, y Ometepec, Guerrero, descrita en este trabajo muestra que tiene características muy específicas de difícil replicación en otras regiones del país. En estudios futuros es necesario considerar los diferentes contextos de vulnerabilidad.The scope of this paper was to identify the role of gender for women as workers, through the perception and discourse of health service providers at the 'Health Centers for Indigenous Women' ("Casas de Salud de las Mujeres Indígenas" in Ometepec, Guerrero and Matías Romero, Oaxaca, Mexico. It is a qualitative study, based on a secondary analysis of the interviews conducted as part of the "Rescatando la experiencia de la Casa de la Mujer Indígena: sistematización y evaluación del proceso" project. A strong sense of the value of work and a strong commitment towards the community were identified. Guilt appears as the result of tension between work outside the home and the responsibilities as mothers and wives. The possibility of helping

  19. Deformation near the Casa Diablo geothermal well field and related processes Long Valley caldera, Eastern California, 1993-2000

    Science.gov (United States)

    Howle, J.F.; Langbein, J.O.; Farrar, C.D.; Wilkinson, S.K.

    2003-01-01

    Regional first-order leveling lines, which extend from Lee Vining, CA, to Tom's Place, CA, have been surveyed periodically since 1957 by the U.S. Geological Survey (USGS), the National Geodetic Survey (NGS), and Caltrans. Two of the regional survey lines, or leveling networks, intersect at the Casa Diablo geothermal well field. These leveling networks, referenced to a distant bench mark (C916) near Lee Vining, provide time-series vertical control data of land-surface deformation that began around 1980. These data are also useful for delineating localized subsidence at Casa Diablo related to reservoir pressure and temperature changes owing to geothermal development that began in 1985. A comparison of differences in bench-mark elevations for five time periods between 1983 and 1997 shows the development and expansion of a subsidence bowl at Casa Diablo. The subsidence coincides spatially with the geothermal well field and temporally with the increased production rates and the deepening of injection wells in 1991, which resulted in an increase in the rate of pressure decline. The subsidence, superimposed on a broad area of uplift, totaled about 310 mm by 1997. The USGS established orthogonal tilt arrays in 1983 to better monitor deformation across the caldera. One tilt array (DBR) was established near what would later become the Casa Diablo geothermal well field. This array responded to magmatic intrusions prior to geothermal development, tilting away from the well field. With the start of geothermal fluid extraction in 1985, tilt at the DBR array reversed direction and began tilting into the well field. In 1991, geothermal power production was increased by a factor of four, and reservoir pressures began a period of steep decline. These changes caused a temporary three-fold increase in the tilt rate. The tilt rate became stable in 1993 and was about 40% lower than that measured in 1991-1992, but still greater than the rates measured during 1985-1990. Data from the

  20. Current perspectives in microRNAs (miRNA)

    CERN Document Server

    Ying, Shao-Yao

    2008-01-01

    In this book, many new perspectives of the miRNA research are reviewed and discussed. These new findings provide significant insight into the various mechanisms of miRNAs and offer a great opportunity in developing new therapeutic interventions.

  1. Circular RNA and miR-7 in Cancer

    DEFF Research Database (Denmark)

    Hansen, Thomas Birkballe; Kjems, Jørgen; Damgaard, Christian Kroun

    2013-01-01

    MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often deregulated in cancer. The identification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA activity underscores the increasing complexity of ncRNA-mediated regulatory networks....... Particularly, the recently identified circular RNA, ciRS-7, which acts as a designated miR-7 inhibitor/sponge, has conceptually changed the mechanistic understanding of miRNA networks. As miR-7 modulates the expression of several oncogenes, disclosing the regulation of miR-7 activity will likely advance...... the understanding of various cancer etiologies. Here, we review the current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways and discuss possible models explaining the relevance of coexpressing miR-7 along with a circRNA inhibitor....

  2. miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    McKenna, Declan J., E-mail: dj.mckenna@ulster.ac.uk [Biomedical Sciences Research Institute, University of Ulster, Coleraine, Co. Derry BT52 1SA (United Kingdom); Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); Patel, Daksha, E-mail: d.patel@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); McCance, Dennis J., E-mail: d.mccance@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom)

    2014-01-05

    A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. We demonstrate that the effect on miR-205 is due to E7 activity, as miR-205 expression is dependent on pRb expression. Finally, we provide evidence that miR-24 effects in the cell may be due to targeting of cyclin dependent kinase inhibitor p27. In summary, these results indicate that expression of both miR-24 and miR-205 are impacted by E6 and/or E7 expression, which may be one mechanism by which HPV onco-proteins can disrupt the balance between proliferation and differentiation in keratinocytes. - Highlights: • miR-24 and miR-205 are induced during keratinocyte differentiation. • This induction is lost in keratinocytes expressing HPV onco-proteins E6 and E7. • miR-205 is dependent upon pRb expression. • miR-24 targets p27 in cycling keratinocytes.

  3. miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes

    International Nuclear Information System (INIS)

    McKenna, Declan J.; Patel, Daksha; McCance, Dennis J.

    2014-01-01

    A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. We demonstrate that the effect on miR-205 is due to E7 activity, as miR-205 expression is dependent on pRb expression. Finally, we provide evidence that miR-24 effects in the cell may be due to targeting of cyclin dependent kinase inhibitor p27. In summary, these results indicate that expression of both miR-24 and miR-205 are impacted by E6 and/or E7 expression, which may be one mechanism by which HPV onco-proteins can disrupt the balance between proliferation and differentiation in keratinocytes. - Highlights: • miR-24 and miR-205 are induced during keratinocyte differentiation. • This induction is lost in keratinocytes expressing HPV onco-proteins E6 and E7. • miR-205 is dependent upon pRb expression. • miR-24 targets p27 in cycling keratinocytes

  4. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong-Kook [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Henry, Jon C. [Department of Surgery, Ohio State University, Columbus, OH 43210 (United States); Jiang, Jinmai [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Esau, Christine [Regulus Therapeutics, Carlsbad, CA (United States); Gusev, Yuriy [Lombardi Cancer Center, Georgetown University, Washington, DC (United States); Lerner, Megan R. [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Postier, Russell G. [Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Brackett, Daniel J. [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Schmittgen, Thomas D., E-mail: Schmittgen.2@osu.edu [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States)

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  5. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    International Nuclear Information System (INIS)

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-01-01

    Research highlights: → The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. → miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. → miR-132 and miR-212 expression is increased by a β2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G 2 /M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the β2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The β2 adrenergic pathway may play an important role in this novel mechanism.

  6. Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4⁺ T cells and peripheral blood from tuberculosis patients.

    Science.gov (United States)

    Kleinsteuber, Katja; Heesch, Kerrin; Schattling, Stefanie; Kohns, Malte; Sander-Jülch, Claudia; Walzl, Gerhard; Hesseling, Anneke; Mayatepek, Ertan; Fleischer, Bernhard; Marx, Florian M; Jacobsen, Marc

    2013-01-01

    The vast majority of Mycobacterium tuberculosis (M. tuberculosis) infected individuals are protected from developing tuberculosis and T cells are centrally involved in this process. MicroRNAs (miRNA) regulate T-cell functions and are biomarker candidates of disease susceptibility and treatment efficacy in M. tuberculosis infection. We determined the expression profile of 29 selected miRNAs in CD4(+) T cells from tuberculosis patients and contacts with latent M. tuberculosis infection (LTBI). These analyses showed lower expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4(+) T cells from tuberculosis patients. Whole blood miRNA candidate analyses verified decreased expression of miR-26a, miR-29a, and miR-142-3p in children with tuberculosis as compared to healthy children with LTBI. Despite marked variances between individual donor samples, trends of increased miRNA candidate expression during treatment and recovery were observed. Functional in vitro analysis identified increased miR-21 and decreased miR-26a expression after re-stimulation of T cells. In vitro polarized Interleukin-17 positive T-cell clones showed activation-dependent miR-29a up-regulation. In order to characterize the role of miR-29a (a described suppressor of Interferon-γ in tuberculosis), we analyzed M. tuberculosis specific Interferon-γ expressing T cells in children with tuberculosis and healthy contacts but detected no correlation between miR-29a and Interferon-γ expression. Suppression of miR-29a in primary human T cells by antagomirs indicated no effect on Interferon-γ expression after in vitro activation. Finally, classification of miRNA targets revealed only a moderate overlap between the candidates. This may reflect differential roles of miR-21, miR-26a, miR-29a, and miR-142-3p in T-cell immunity against M. tuberculosis infection and disease.

  7. Decreased Expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4+ T Cells and Peripheral Blood from Tuberculosis Patients

    Science.gov (United States)

    Schattling, Stefanie; Kohns, Malte; Sander-Jülch, Claudia; Walzl, Gerhard; Hesseling, Anneke; Mayatepek, Ertan; Fleischer, Bernhard; Marx, Florian M.; Jacobsen, Marc

    2013-01-01

    The vast majority of Mycobacterium tuberculosis (M. tuberculosis) infected individuals are protected from developing tuberculosis and T cells are centrally involved in this process. MicroRNAs (miRNA) regulate T-cell functions and are biomarker candidates of disease susceptibility and treatment efficacy in M. tuberculosis infection. We determined the expression profile of 29 selected miRNAs in CD4+ T cells from tuberculosis patients and contacts with latent M. tuberculosis infection (LTBI). These analyses showed lower expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4+ T cells from tuberculosis patients. Whole blood miRNA candidate analyses verified decreased expression of miR-26a, miR-29a, and miR-142-3p in children with tuberculosis as compared to healthy children with LTBI. Despite marked variances between individual donor samples, trends of increased miRNA candidate expression during treatment and recovery were observed. Functional in vitro analysis identified increased miR-21 and decreased miR-26a expression after re-stimulation of T cells. In vitro polarized Interleukin-17 positive T-cell clones showed activation-dependent miR-29a up-regulation. In order to characterize the role of miR-29a (a described suppressor of Interferon-γ in tuberculosis), we analyzed M. tuberculosis specific Interferon-γ expressing T cells in children with tuberculosis and healthy contacts but detected no correlation between miR-29a and Interferon-γ expression. Suppression of miR-29a in primary human T cells by antagomirs indicated no effect on Interferon-γ expression after in vitro activation. Finally, classification of miRNA targets revealed only a moderate overlap between the candidates. This may reflect differential roles of miR-21, miR-26a, miR-29a, and miR-142-3p in T-cell immunity against M. tuberculosis infection and disease. PMID:23613882

  8. LBNE-NuMI Muon Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, Mike [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Mills, Geoffrey [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Marino, Alysia [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Zimmerman, Eric [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Lane, Charles [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Bern, Hans [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2013-08-15

    This is a technical scope of work (TSW) that concerns Fermi National Laboratory and the experiments of LBNE who have committed to participate in muon detector prototype tests to be carried out in the NuMi alcoves during the 2013-2017 Fermilab Neutrino program.

  9. miRNAs: Small but deadly

    African Journals Online (AJOL)

    Jane

    2011-08-24

    Aug 24, 2011 ... Levels of some miRNAs are found altered in cancers, so we might expect these regulatory ..... males is the prostate cancer (PCa) (Jemal et al., 2008). ..... 1 growth factor receptor family members HER-1, HER-2, and HER-3.

  10. Saginaw Bay, MI LiDAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — TASK NAME:(NRCS) Saginaw Bay, MI LiDAR LiDAR Data Acquisition and Processing Production Task USGS Contract No. G10PC00057 Task Order No. G11PD01254 Woolpert Order...

  11. Low antigenicity of hematopoietic progenitor cells derived from human ES cells

    Directory of Open Access Journals (Sweden)

    Eun-Mi Kim

    2010-02-01

    Full Text Available Eun-Mi Kim1, Nicholas Zavazava1,21Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa, USA; 2Immunology Graduate Program, University of Iowa, Iowa City, Iowa, USAAbstract: Human embryonic stem (hES cells are essential for improved understanding of diseases and our ability to probe new therapies for use in humans. Currently, bone marrow cells and cord blood cells are used for transplantation into patients with hematopoietic malignancies, immunodeficiencies and in some cases for the treatment of autoimmune diseases. However, due to the high immunogenicity of these hematopoietic cells, toxic regimens of drugs are required for preconditioning and prevention of rejection. Here, we investigated the efficiency of deriving hematopoietic progenitor cells (HPCs from the hES cell line H13, after co-culturing with the murine stromal cell line OP9. We show that HPCs derived from the H13 ES cells poorly express major histocompatibility complex (MHC class I and no detectable class II antigens (HLA-DR. These characteristics make hES cell-derived hematopoietic cells (HPCs ideal candidates for transplantation across MHC barriers under minimal immunosuppression.Keywords: human embryonic stem cells, H13, hematopoiesis, OP9 stromal cells, immunogenicity

  12. DESENVOLVIMENTO DE MUDAS DE ALFACE EM DIFERENTES SUBSTRATOS E CONCENTRAÇÕES

    Directory of Open Access Journals (Sweden)

    Mário Pechara Jaeggi

    2017-04-01

    Full Text Available Objetivou-se com este trabalho avaliar o desempenho de diferentes substratos e concentrações, no desenvolvimento de cultivares de alface. O experimento foi conduzido em casa de vegetação, localizada no setor de Agroecologia do Instituto Federal do Espírito Santo Campus de Alegre, ES. O delineamento utilizado foi em blocos casualizados disposto em um esquema fatorial 4x3x2, sendo quatro tipos substratos (S1: Plantmax®; S2: composto orgânico; S3: húmus de minhoca; S4: borra de cana-de-açúcar, três concentrações (100%, 75% e 50% e duas cultivares de alface. As variáveis avaliadas foram: massa fresca da parte aérea, massa fresca toal e altura da parte aérea. As mudas foram avaliadas ao 21° dia após semeio. Os resultados demostraram que substratos orgânicos se mostraram eficazes para o desenvolvimento das cultivares de alface, os quais podem ser utilizados em diferentes concentrações em substituição ao substrato comercial.

  13. miR-21 Is Linked to Glioma Angiogenesis

    DEFF Research Database (Denmark)

    Hermansen, Simon Kjær; Nielsen, Boye Schnack; Aaberg-Jessen, Charlotte

    2016-01-01

    MicroRNA-21 (miR-21) is the most consistently over-expressed microRNA (miRNA) in malignant gliomas. We have previously reported that miR-21 is upregulated in glioma vessels and subsets of glioma cells. To better understand the role of miR-21 in glioma angiogenesis and to characterize miR-21......-localized with the hypoxia- and angiogenesis-associated markers HIF-1α (p=0.0020) and VEGF (p=0.0096), whereas the putative miR-21 target, PTEN, was expressed independently of miR-21. Expression of stem cell markers Oct4, Sox2 and CD133 was not associated with miR-21. In six glioblastoma cultures, miR-21 did not correlate...... with the six markers. These findings suggest that miR-21 is linked to glioma angiogenesis, that miR-21 is unlikely to regulate PTEN, and that miR-21-positive tumor cells do not possess stem cell characteristics....

  14. Protein-driven inference of miRNA-disease associations

    DEFF Research Database (Denmark)

    Mørk, Søren; Pletscher-Frankild, Sune; Palleja, Albert

    2014-01-01

    MicroRNAs (miRNAs) are a highly abundant class of non-coding RNA genes involved in cellular regulation and thus also diseases. Despite miRNAs being important disease factors, miRNA-disease associations remain low in number and of variable reliability. Furthermore, existing databases and prediction...

  15. miR319, miR390, and miR393 Are Involved in Aluminum Response in Flax (Linum usitatissimum L.).

    Science.gov (United States)

    Dmitriev, Alexey A; Kudryavtseva, Anna V; Bolsheva, Nadezhda L; Zyablitsin, Alexander V; Rozhmina, Tatiana A; Kishlyan, Natalya V; Krasnov, George S; Speranskaya, Anna S; Krinitsina, Anastasia A; Sadritdinova, Asiya F; Snezhkina, Anastasiya V; Fedorova, Maria S; Yurkevich, Olga Yu; Muravenko, Olga V; Belenikin, Maxim S; Melnikova, Nataliya V

    2017-01-01

    Acid soils limit agricultural production worldwide. Major reason of crop losses in acid soils is the toxicity of aluminum (Al). In the present work, we investigated expression alterations of microRNAs in flax ( Linum usitatissimum L.) plants under Al stress. Flax seedlings of resistant (TMP1919 and G1071/4_k) and sensitive (Lira and G1071/4_o) to Al cultivars and lines were exposed to AlCl 3 solution for 4 and 24 hours. Twelve small RNA libraries were constructed and sequenced using Illumina platform. In total, 97 microRNAs from 18 conserved families were identified. miR319, miR390, and miR393 revealed expression alterations associated with Al treatment of flax plants. Moreover, for miR390 and miR393, the alterations were distinct in sensitive and resistant to Al genotypes. Expression level changes of miR319 and miR390 were confirmed using qPCR analysis. In flax, potential targets of miR319 are TCPs, miR390-TAS3 and GRF5, and miR393-AFB2-coding transcripts. TCPs, TAS3, GRF5, and AFB2 participate in regulation of plant growth and development. The involvement of miR319, miR390, and miR393 in response to Al stress in flax was shown here for the first time. We speculate that these microRNAs play an important role in Al response via regulation of growth processes in flax plants.

  16. Casas e portas da memória e do patrimônio

    Directory of Open Access Journals (Sweden)

    Mario Chagas

    2007-12-01

    Full Text Available Apresenta reflexões em torno do conceito de patrimônio, desde a sua origem até a contemporaneidade. Afirma que existe uma relação intrínseca entre patrimônio e poder, que permanece na relação entre patrimônio e propriedade, seja material ou espiritual, econômica ou simbólica e a sua vinculação à idéia de preservação. Destaca que a noção de posse parece ser mais adequada aos museus do que a de propriedade Sugere que o caráter preservacionista e o sentido de posse estão na raiz da instituição do patrimônio e do museu (casa de memória e poder. Ressalta que a preservação como prática social que é utilizada para a construção de determinadas narrativas tem um caráter subjetivo, que é mascarado por discursos que se pretendem positivos, científicos e objetivos. Conclui que o que está em jogo nos museus e também no domínio do patrimônio cultural é memória, esquecimento, resistência e poder, perigo e valor, múltiplos significados e funções, silêncio e fala, destruição e preservação. E por tudo isso interessa compreendê-los em sua dinâmica social e interessa compreender o que se pode fazer com eles, contra eles, apesar e a partir deles.

  17. Varicella at "Casa Garrahan", 2008-2013: Assessment of postexposure prophylaxis measures.

    Science.gov (United States)

    Ruvinsky, Silvina; Taicz, Moira; Pérez, M Guadalupe; Mónaco, Andrea; García Escudé, Natalia; Inda, Laura; Carbonaro, Mirta; Bologna, Rosa

    2015-06-01

    Casa Garrahan (CG) accommodates children with complex conditions referred nationwide; these children are seen in children's hospitals located in the Autonomous City of Buenos Aires. Varicella is a highly-contagious disease, with attack rates of up to 90% among susceptible individuals. In closed communities, the implementation of outbreak control measures is critical. To describe the characteristics of children exposed to varicella at CG, the implemented prophylaxis measures and their effectiveness. Prospective, cohort study. Children exposed to varicella at CG between2008 and 2013, their demographic and clinical characteristics, immunization and/or history of varicella, prophylaxis measures, and secondary attack rate were assessed. N: 107. Fifty-three percent (n: 57) were girls. Their median age was 84 months old [interquartile range (IQR): 24-144]. Ninety-five percent (n: 102) had an underlying disease [hemato-oncological disease: 39% (n: 42); neurological disease: 18% (n: 19); congenital heart disease: 9% (n: 10); and post-operative period: 65 (n: 6)]. Fifty percent had some degree of immunosuppression (n: 54). Twenty-nine percent (n: 31) referred to have had varicella; 27% (n: 29) indicated that they never had the infection; and 41% (n: 44) did not recall a history of varicella. Only 3% (n: 3) had been vaccinated. Based on their immune status, age and history of varicella, acyclovir was indicated as prophylaxis in 61% (n: 65); immunization in 10% (n: 10); and gamma globulin in 1 patient. No adverse effects were observed in relation to the different prophylaxis measures. No secondary cases were observed at 30 days. Implemented measures were effective to prevent secondary cases. Among healthy and immunocompromised children, prophylaxis with acyclovir was effective and well-tolerated.

  18. Casas estudio: alternativa pedagógica para el proyecto de fin de carrera

    Directory of Open Access Journals (Sweden)

    Edison Henao Carvajal

    2011-12-01

    Full Text Available Este artículo da cuenta del proceso de elaboración del trabajo de grado de algunos de los estudiantes inscritos en la Línea de Profundización en Proyectos Arquitectónicos, del programa curricular de Arquitectura, de la sede Manizales de la Universidad Nacional de Colombia, durante los semestres segundo del 2009 y primero del 2010. El propósito de la experiencia, coordinada por los autores del artículo, consistió en poner a prueba un método de enseñanza-aprendizaje para el taller de proyectos de fin de carrera, en el marco de una concepción pedagógica basada en la solución de problemas de forma, a partir del reconocimiento y de la asimilación de las soluciones universales presentes en las obras de los grandes maestros de la arquitectura. En contravía de la metodología de concepción arquitectónica contemporánea, basada en “la realización de las ideas del autor”, el taller se centró en recuperar las maneras de operar de la modernidad arquitectónica, en las que tiene mayor importancia la búsqueda de una implantación correcta de la obra, la solución de los requerimientos programáticos del proyecto, su concepción constructiva y el planteamiento consistente de los espacios requeridos, en este caso, para una casa-estudio.

  19. Sin trabajo y sin casa: Subjetividades de la exclusión social

    Directory of Open Access Journals (Sweden)

    María Andrea Benítez

    2009-12-01

    Full Text Available Este estudio aborda la problemática de la exclusión laboral y habitacional, considerando que para quienes las padecen, la exclusión del trabajo (en términos de empleo y de condiciones dignas de habitación, implica una condición estigmatizante y deshonrosa que se desea abandonar, pero paradójicamente, visibilizar esta condición, puede constituir un paso para la superación de la misma, a través de la obtención de planes laborales o de asistencia habitacional. De esta forma se constituye una tensión que estructura los procesos de subjetivación y en consecuencia los modos de socialización de quienes atraviesan situaciones de exclusión del hábitat y el trabajo. Este trabajo se realizó sobre la base de entrevistas en profundidad a informantes que han vivido carencias de casa y trabajo. En ellas se privilegió la narración de las vivencias y definiciones propias de los actores.This study is focused on non - inclusion problematic related to labor and housing contexts. It considers a main paradox: the persons who are affected by non-inclusion situations because they have not granted minimum conditions of full employment and decent habitation, feel that those situations are stigmatizing and shameful. But in order overcome this non-inclusion condition -by obtaining employment plans or housing assistance- they have to make it visible. In this scenery emerges a conflict that configures subjectivity constitution and socialization processes. The study was based on opened interviews developed to a group of subject who have experienced a lack of home and work. The interviews emphasized subjective narrative of actors' experiences.

  20. Notas sobre la casa de los obispos de Córdoba en la Edad Media

    Directory of Open Access Journals (Sweden)

    Iluminado Sanz Sancho

    2005-01-01

    Full Text Available El estudio de la Casa y Corte de los Reyes ha supuesto una serie de novedades y avances importantes en la historiografía europea y española, que se ha aplicado también a algunos estados nobiliarios. Pero, hasta el momento, esta problemática y su estudio no se han proyectado sobre los altos eclesiásticos y menos aún en los tiempos medievales. Él presente artículo, reconociendo la dificultad que conlleva la carencia de fuentes suficientes, pretende, no obstante, plantear la posibilidad de este tipo de estudios en la Historia de la Iglesia y un procedimiento oportuno para su tratamiento. Igualmente, presentar algunos datos y noticias concretas, pertenecientes a la Iglesia de Córdoba, que pueden avalar el interés de este estudio y aventurar un mejor conocimiento de la Historia en la Edad Media.The study of the Royal House and Court has meant a series of important newness and advances in the European and Spanish historiography, and has also been applied to some noble estafes. Although, so far, the study of this subject has not been projected over the upper Ecclesiastics and even less during the Middie Ages. The present article, admitting the difficulty of not having enough sources, attempts, nonetheless, to introduce the possibility of this type of studies in the history of the Church and an appropriate method for its study. It also tries to show some specific data and news belonging to the Church of Córdoba, all of it may guarantee the interest of this study and foretaste a better knowledge of the History during the Middie Ages.

  1. A Tarefa de Casa na Inclusão Escolar: Alunos com Deficiencia Física

    Directory of Open Access Journals (Sweden)

    Carolina Cangemi GREGORUTTI

    Full Text Available RESUMO: a tarefa de casa (TC pode contribuir para a realização de aprendizagem significativa e para complementar e reforçar as atividades realizadas em sala de aula. Objetivou-se identificar e analisar como as TC estão sendo propostas para alunos com deficiência física (DF inseridos em classes de ensino comum, a partir da percepção de professoras e cuidadoras familiares. Participaram do estudo 15 professoras e 15 cuidadoras familiares de crianças com DF, inseridas em classes de ensino comum. Para a coleta de dados foram utilizados dois roteiros de entrevista semiestruturados, sendo um aplicado para as professoras e outro para as cuidadoras familiares. As verbalizações foram gravadas e transcritas na íntegra para posterior análise de conteúdo e categorização. Os resultados sugerem que o professor, em muitos casos, não adapta as TC para atender as demandas do aluno e, em outros, não oferece tarefa para o aluno com DF na mesma proporção que o faz para os demais alunos. Com relação às famílias, os resultados indicam que estas percebem as dificuldades da criança e, ao mesmo tempo, angustiam-se com a falta de comunicação com a escola nesse quesito, o que ocasiona questionamentos e dúvidas em relação ao desempenho do aluno. Os resultados deste estudo podem ser úteis no contexto da Educação Inclusiva, no sentido de a TC adquirir uma função particularmente interessante, pois, se bem gerenciada, pode funcionar como uma atividade mediadora da interlocução entre a escola e a família.

  2. Da casa ao hotel: entre a hospitalidade e a economia do turismo

    Directory of Open Access Journals (Sweden)

    Felipe José Comunello

    2015-01-01

    Full Text Available O município de São Joaquim, na região serrana de Santa Catarina, tem sido destacado pela imprensa escrita e televisiva nacional como a cidade mais fria do Brasil, ao longo dos últimos vinte anos. Em pesquisa realizada para tese de doutorado, identifiquei que muitas proprietárias de pousadas, as “pousadeiras” como elas mesmas se chamam, começaram abrigando turistas em dificuldades em dias de frio intenso, quando não há hotéis e pousadas suficientes na cidade. A partir disso, elas acreditaram ser possível transformar suas casas em pousadas, tendo diante de si um problema também compartilhado com os profissionais do turismo, a chamada sazonalidade dos turistas. Tal fato provoca dúvidas sobre a sustentação econômica das pousadas e inquietação aos profissionais quanto ao sucesso econômico do turismo. Nesse artigo, isso é analisado tendo como referência uma proposta de parceria recebida por meus interlocutores por parte da operadora de turismo CVC e da empresa de eventos da RBS, afiliada da Rede Globo em Santa Catarina. A discussão é em torno de questões a partir de uma antropologia da hospitalidade. A análise sugere que essa parceria ameaça uma ordem moral estabelecida com base em determinados valores de hospitalidade para com estranhos, principalmente o aquecimento perante o frio.

  3. Identification of novel miRNAs and miRNA dependent developmental shifts of gene expression in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Shuhua Zhan

    Full Text Available microRNAs (miRNAs are small, endogenous RNAs of 20 approximately 25 nucleotides, processed from stem-loop regions of longer RNA precursors. Plant miRNAs act as negative regulators of target mRNAs predominately by slicing target transcripts, and a number of miRNAs play important roles in development. We analyzed a number of published datasets from Arabidopsis thaliana to characterize novel miRNAs, novel miRNA targets, and miRNA-regulated developmental changes in gene expression. These data include microarray profiling data and small RNA (sRNA deep sequencing data derived from miRNA biogenesis/transport mutants, microarray profiling data of mRNAs in a developmental series, and computational predictions of conserved genomic stem-loop structures. Our conservative analyses identified five novel mature miRNAs and seven miRNA targets, including one novel target gene. Two complementary miRNAs that target distinct mRNAs were encoded by one gene. We found that genes targeted by known miRNAs, and genes up-regulated or down-regulated in miRNA mutant inflorescences, are highly expressed in the wild type inflorescence. In addition, transcripts upregulated within the mutant inflorescences were abundant in wild type leaves and shoot meristems and low in pollen and seed. Downregulated transcripts were abundant in wild type pollen and seed and low in shoot meristems, roots and leaves. Thus, disrupting miRNA function causes the inflorescence transcriptome to resemble the leaf and meristem and to differ from pollen and seed. Applications of our computational approach to other species and the use of more liberal criteria than reported here will further expand the number of identified miRNAs and miRNA targets. Our findings suggest that miRNAs have a global role in promoting vegetative to reproductive transitions in A. thaliana.

  4. Cloning and characterization of pre-miR159a and pre-miR1123 from ...

    African Journals Online (AJOL)

    Although many miRNA genes are conserved across the plant species, the same gene family varies significantly in size and genomic organization in different species. ... Sequence identity matrix suggests 43-82% variation in precursor of Tae AL pre-miR159a (Tae Agra local pre-miR159a) across the species. On the other ...

  5. ¿Es la Internet un derecho?

    Directory of Open Access Journals (Sweden)

    Eduardo Villanueva Mansilla

    2010-09-01

    Full Text Available Internet ha sido declarado como derecho, lo que hace que su acceso, uso y penetración sean considerados como prioritarios en todas las zonas del planeta. La intención de este ensayo es esbozar cuáles serían estos efectos. El derecho al Internet es simplemente la garantía de poder participar de la vida en sociedad sea como ciudadano o como consumidor sin restricción alguna. El acceso al Internet no es simple ni barato, implica un conjunto de acciones que requieren intervención del Estado, de varios actores económicos y del propio ciudadano. Asume el tratamiento de las complejidades de este derecho y el desafío para Latinoamérica.

  6. Era uma casa ...!? discurso, dinâmica familiar e contingências da rua ¿Era una casa ...!? discurso, dinámica familiar y contingencias de la calle It was a home...!? speech, family dynamics and contingencies of the street

    Directory of Open Access Journals (Sweden)

    Paula Cristina Monteiro de Barros

    2009-09-01

    Full Text Available Crianças e adolescentes em situação de rua refletem um sintoma social marcado essencialmente por violência, transgressões, abandono e a precocidade que a vida na rua impõe. Uma realidade perpassada por aspectos sociais, políticos, culturais, históricos, econômicos, que configuram uma complexa trama social. Na experiência em uma instituição (Olinda - Brasil, deparamo-nos com sujeitos com histórias singulares, que adotaram a mesma saída - a rua - para o conflito vivido. Partindo de um recorte dessa realidade, propomos uma leitura de aspectos da dinâmica familiar que fragilizam o sujeito, como as palavras que lhe são endereçadas, as quais o marcam com atributos que culminam com a identidade "menino de rua". Que lugar é atribuído ao sujeito que faz um rompimento com a casa e a família? Propomos também pensar estratégias de intervenção junto às famílias no sentido de restituir ou construir um lugar de pertencimento para essas crianças e para esses pais no âmbito familiar.Niños y adolescentes en situación de calle reflejan un síntoma social marcado esencialmente por la violencia, por las transgresiones, por el abandono y por el comportamiento precoz que la vida por la calle se impone. Una realidad configurada por aspectos sociales, políticos, culturales, históricos, económicos, que se enlazan en una compleja trama social. En la experiencia en una institución (Olinda - Brasil, nos deparamos con sujetos con historias singulares, pero que adoptaron la misma salida - la calle - para el conflicto que han vivido. A partir de un recorte de esa realidad, hemos propuesto una lectura de aspectos de la dinámica familiar que fragilizan el sujeto, como las palabras que son dirigidas a ellos, os marcan con la identidad "niños de calle". ¿Qué sitio es atribuido al sujeto que hace un rompimiento con la casa y con la familia? A partir de esa lectura, es nuestro propósito, también, pensar estrategias de intervención junto a la

  7. miR-10 in development and cancer

    DEFF Research Database (Denmark)

    Lund, Anders Henrik

    2010-01-01

    The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox ...... function to the miRNA repertoire.Cell Death and Differentiation advance online publication, 22 May 2009; doi:10.1038/cdd.2009.58....

  8. Epigenetic architecture and miRNA: reciprocal regulators

    DEFF Research Database (Denmark)

    Wiklund, Erik D; Kjems, Jørgen; Clark, Susan J

    2010-01-01

    Deregulation of epigenetic and microRNA (miRNA) pathways are emerging as key events in carcinogenesis. miRNA genes can be epigenetically regulated and miRNAs can themselves repress key enzymes that drive epigenetic remodeling. Epigenetic and miRNA functions are thus tightly interconnected......RNAs) are considered especially promising in clinical applications, and their biogenesis and function is a subject of active research. In this review, the current status of epigenetic miRNA regulation is summarized and future therapeutic prospects in the field are discussed with a focus on cancer....

  9. Discourse and Practice of Violence in the Italian Extreme Right: Frames, Symbols, and Identity-Building in CasaPound Italia

    Directory of Open Access Journals (Sweden)

    Pietro Castelli Gattinara

    2014-09-01

    Full Text Available An investigation of the neo-Fascist organization CasaPound Italia, focusing on how political violence is framed in its public discourse, and on the role it plays as a constitutive element of the group’s collective identity. Starting from the conceptualization of violence in Italian Fascism, we focus on CasaPound’s practices, discourse, and ideology. The analysis combines findings from nineteen in-depth interviews with CasaPound members and participant observation at protest events and activities. This paper disentangles CasaPound’s relationship with political violence, differentiating its discursive, aesthetic, and identity-building dimensions. Although in the external discourse of the group, violent activities are only accepted as a tool of self-determination and self-defence, we find that a cult of violence inspired by traditional Fascism emerges from the semiotic repertoire mobilized by CasaPound, and is reiterated by means of experiences of collective socialization based on violence.

  10. Contribution of the CASA system, based on open source software, to the assessment of sperm characteristics: informetric and usage-based approaches

    Directory of Open Access Journals (Sweden)

    Giovano Neumann

    Full Text Available ABSTRACT By using informetric tools, we evaluated the contribution and impact of the open source computer-assisted sperm analysis (CASA software on sperm studies, especially pertaining to fish. The article was cited 125 times between 2007 and 2014 in four publication types (articles, doctoral dissertations, master’s theses, and books. Among articles, the number of citations increased at rate of three citations per year and the calculated h-index was 17. Of the studies that cited Wilson-Leedy and Ingermann (2007, fish were the main group of organisms studied (61 articles; of these, 34 articles used the open source CASA, covering 23 marine or freshwater species. Studies conducted in 12 countries were published in 21 journals. Four ways of knowledge sharing were identified: by direct partnership with the system developers; by knowledge multipliers, who worked directly with the system developers; by groups that adopted the system by their own initiative; and through expansion of cooperation networks with autodidacts. In regard to specific analytical procedures, motility, curvilinear velocity, average path velocity, and straight-line velocity were the main CASA parameters used to describe sperm movements. As expected, the usage of this tool has been increasing over the years, being a reliable and versatile alternative to more costly similar platforms. However, the potential of the CASA system has not been completely explored and it is our assessment that some results produced by CASA are poorly understood or even misunderstood.

  11. ULCERA GASTRODUODENAL EM CÃES

    Directory of Open Access Journals (Sweden)

    Francisco Assis Uma Costa

    1993-12-01

    Full Text Available As ulcerações no sistema digestivo de cães são consideradas raras. São descritos dois casos de úlcera gastroduodenal em cães. O primeiro animal apresentou úlcera no duodeno próxima!. O segundo mostrou úlcera perfurada na região pilórica do estômago. Nenhum dos animais apresentou evidências de sangramento, mas as lesões eram profundas e arredondadas. Não houve evidência de patologias concorrentes.

  12. Appraisal and standardization of curvilinear velocity (VCL) cut-off values for CASA analysis of Japanese quail (Coturnix japonica) sperm.

    Science.gov (United States)

    Farooq, U; Malecki, I A; Mahmood, M; Martin, G B

    2017-06-01

    One of the basic steps in objective analysis of sperm motility is the subdivision of a motile sperm population into slow, medium and rapid categories based on their velocity. However, for CASA analysis of quail sperm, the velocity values for categorization of slow, medium and rapid sperm have not yet been standardized. To identify the cut-off values of "velocity curvilinear" (VCL) for quail sperm categorization, we captured and analysed 22,300 tracks of quail sperm using SCA ® -CASA. The median and mean VCL values were 85 and 97 μm/s. To define the VCL cut-off values, we used two methods. In the first, we identified the upper (rapid sperm) and lower (slow sperm) cut-off values using: (i) median VCL ± 25% or ± 50% or ± 75% of median VCL value; (ii) first and third quartile values of VCL data (i.e. 25% cut-off setting); and (iii) 33% and 66% of VCL data. Among these settings, sperm categories and their corresponding motility characteristics recorded using the "25%" setting (i.e. slow ≤36 ≤ medium ≤154 ≤ rapid) were found the most realistic and coherent with male ranking by fertility. In the second method, we calculated heteroscedasticity in the total VCL data using PCA and the two-step clustering method. With this approach, the mean of the high and low clusters was 165 and 51 μm/s, respectively. Together, the mean from two methods suggested that, for SCA ® -CASA categorization of quail sperm, sperm should be classed as "rapid" at VCL ≥160 μm/s and "slow" at VCL ≤45 μm/s. © 2017 Blackwell Verlag GmbH.

  13. Monitoring ground-surface heating during expansion of the Casa Diablo production well field at Mammoth Lakes, California

    Science.gov (United States)

    Bergfeld, D.; Vaughan, R. Greg; Evans, William C.; Olsen, Eric

    2015-01-01

    The Long Valley hydrothermal system supports geothermal power production from 3 binary plants (Casa Diablo) near the town of Mammoth Lakes, California. Development and growth of thermal ground at sites west of Casa Diablo have created concerns over planned expansion of a new well field and the associated increases in geothermal fluid production. To ensure that all areas of ground heating are identified prior to new geothermal development, we obtained high-resolution aerial thermal infrared imagery across the region. The imagery covers the existing and proposed well fields and part of the town of Mammoth Lakes. Imagery results from a predawn flight on Oct. 9, 2014 readily identified the Shady Rest thermal area (SRST), one of two large areas of ground heating west of Casa Diablo, as well as other known thermal areas smaller in size. Maximum surface temperatures at 3 thermal areas were 26–28 °C. Numerous small areas with ground temperatures >16 °C were also identified and slated for field investigations in summer 2015. Some thermal anomalies in the town of Mammoth Lakes clearly reflect human activity.Previously established projects to monitor impacts from geothermal power production include yearly surveys of soil temperatures and diffuse CO2 emissions at SRST, and less regular surveys to collect samples from fumaroles and gas vents across the region. Soil temperatures at 20 cm depth at SRST are well correlated with diffuse CO2 flux, and both parameters show little variation during the 2011–14 field surveys. Maximum temperatures were between 55–67 °C and associated CO2 discharge was around 12–18 tonnes per day. The carbon isotope composition of CO2 is fairly uniform across the area ranging between –3.7 to –4.4 ‰. The gas composition of the Shady Rest fumarole however has varied with time, and H2S concentrations in the gas have been increasing since 2009.

  14. Exploration of miRNA families for hypotheses generation.

    KAUST Repository

    Kamanu, T.K.

    2013-10-15

    Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.

  15. Entropy-based model for miRNA isoform analysis.

    Directory of Open Access Journals (Sweden)

    Shengqin Wang

    Full Text Available MiRNAs have been widely studied due to their important post-transcriptional regulatory roles in gene expression. Many reports have demonstrated the evidence of miRNA isoform products (isomiRs in high-throughput small RNA sequencing data. However, the biological function involved in these molecules is still not well investigated. Here, we developed a Shannon entropy-based model to estimate isomiR expression profiles of high-throughput small RNA sequencing data extracted from miRBase webserver. By using the Kolmogorov-Smirnov statistical test (KS test, we demonstrated that the 5p and 3p miRNAs present more variants than the single arm miRNAs. We also found that the isomiR variant, except the 3' isomiR variant, is strongly correlated with Minimum Free Energy (MFE of pre-miRNA, suggesting the intrinsic feature of pre-miRNA should be one of the important factors for the miRNA regulation. The functional enrichment analysis showed that the miRNAs with high variation, particularly the 5' end variation, are enriched in a set of critical functions, supporting these molecules should not be randomly produced. Our results provide a probabilistic framework for miRNA isoforms analysis, and give functional insights into pre-miRNA processing.

  16. CASAS COMERCIALES Y SUS OPERACIONES EN VALPARAÍSO: El Caso del Carbón Extranjero. 1890-1905

    Directory of Open Access Journals (Sweden)

    Aldo Meneses Inostroza

    2017-04-01

    Full Text Available Chile posterior a la Guerra del Pacifico, vio incrementada fuertemente su actividad económica, con la integración del salitre, teniendo como principal combustible el carbón. De ahí que resulte importante conocer esta actividad donde se aprovisionó principalmente de hullas australianas e inglesas, permitiendo a su vez vislumbrar la mentalidad de quienes llevaron a cabo esta actividad, las casas comerciales involucradas, sus prácticas en lo relacionado a las ventas, bandas de precio de las hullas y formas de pago

  17. Minha Casa, Minha Vida Program: Public Policy Social (ExInclusion of the Population In Street Situation

    Directory of Open Access Journals (Sweden)

    Domingos do Nascimento Nonato

    2016-12-01

    Full Text Available The objective is to reflect the requirements used by the program Minha Casa, Minha Vida to select beneficiaries with housing units have correspondence with socioeconomic vulnerability experienced by people in the streets. We chose methodologically the bibliographical and documentary research, which was fundamental to deepen reflections on the object and the proposed objective. It was concluded that such requirements do not correlate with the degree of misery to that experienced by population segment, which is excluded from this housing public policy, and has subtracted by the Government itself the possibility of exercising the fundamental right to housing.

  18. Direito a moradia e inclusão social: aspectos positivos e negativos do "programa minha casa minha vida"

    OpenAIRE

    Desordi, Jordana Laís; Strücker, Bianca

    2016-01-01

    O presente artigo pretende analisar aspectos conceituais e doutrinários referentes ao direito à moradia e à inclusão social, fazendo referência aos aspectos positivos e negativos do programa habitacional brasileiro “Minha Casa Minha Vida” (PMCMV). A pesquisa dá ênfase ao PMCMV, momento em que é analisada a legislação que cria e institui o Programa em suas duas versões existentes até este momento. Destaca-se, ainda, os reflexos que o programa causou ao proporcionar o acesso do indivíduo a sua ...

  19. [Trends and perspectives of nursing administration: a study in the Santa Casa hospital of Belo Horizonte-MG].

    Science.gov (United States)

    Spagnol, Carla Aparecida; Ferraz, Clarice Aparecida

    2002-01-01

    The "Santa Casa" Hospital of Belo Horizonte has implemented a new management system that has characterized it as a flexible organization. Based on this context, the authors of this research defined the following objectives: to analyze nursing administration by considering the implementation of the Management System (SIGESC), to describe how the nursing team perceives communication, the decision-making process and interpersonal relationships, to identify possible trends and perspectives present in the administrative practice developed. A time of transition in nursing administration that presents characteristics of classical management and contemporaneous management was shown as well as trends and perspectives that will contribute to the reorganization of nursing work in hospitals.

  20. Frecuencia de comidas fuera de casa y calidad de hidratos de carbono y de grasas en el proyecto SUN

    OpenAIRE

    Villacis, C. (Cecilia); Zazpe, I. (Itziar); Santiago, S. (Susana); Fuente-Arrillaga, C. (Carmen) de la; Bes-Rastrollo, M. (Maira); Martinez-Gonzalez, M.A. (Miguel Ángel)

    2015-01-01

    Objetivo: Investigar la asociación entre la frecuencia de comidas fuera de casa (CFC) con a) la calidad de hidratos de carbono y b) la calidad de grasas. Materiales y métodos: Se evaluaron 19.371 participantes de la cohorte SUN que completaron un cuestionario basal de frecuencia de consumo de alimentos previamente validado. Se utilizaron los índices de calidad de hidratos de carbono (ICHC) en una escala de 4 a 20 y de grasas (ICG) en una escala de 0,62 a 5,92. En ambos...

  1. Evolutionary relationships between miRNA genes and their activity.

    Science.gov (United States)

    Zhu, Yan; Skogerbø, Geir; Ning, Qianqian; Wang, Zhen; Li, Biqing; Yang, Shuang; Sun, Hong; Li, Yixue

    2012-12-22

    The emergence of vertebrates is characterized by a strong increase in miRNA families. MicroRNAs interact broadly with many transcripts, and the evolution of such a system is intriguing. However, evolutionary questions concerning the origin of miRNA genes and their subsequent evolution remain unexplained. In order to systematically understand the evolutionary relationship between miRNAs gene and their function, we classified human known miRNAs into eight groups based on their evolutionary ages estimated by maximum parsimony method. New miRNA genes with new functional sequences accumulated more dynamically in vertebrates than that observed in Drosophila. Different levels of evolutionary selection were observed over miRNA gene sequences with different time of origin. Most genic miRNAs differ from their host genes in time of origin, there is no particular relationship between the age of a miRNA and the age of its host genes, genic miRNAs are mostly younger than the corresponding host genes. MicroRNAs originated over different time-scales are often predicted/verified to target the same or overlapping sets of genes, opening the possibility of substantial functional redundancy among miRNAs of different ages. Higher degree of tissue specificity and lower expression level was found in young miRNAs. Our data showed that compared with protein coding genes, miRNA genes are more dynamic in terms of emergence and decay. Evolution patterns are quite different between miRNAs of different ages. MicroRNAs activity is under tight control with well-regulated expression increased and targeting decreased over time. Our work calls attention to the study of miRNA activity with a consideration of their origin time.

  2. Role of miRNA-9 in Brain Development

    Directory of Open Access Journals (Sweden)

    Balachandar Radhakrishnan

    2016-01-01

    Full Text Available MicroRNAs (miRNAs are a class of small regulatory RNAs involved in gene regulation. The regulation is effected by either translational inhibition or transcriptional silencing. In vertebrates, the importance of miRNA in development was discovered from mice and zebrafish dicer knockouts. The miRNA-9 (miR-9 is one of the most highly expressed miRNAs in the early and adult vertebrate brain. It has diverse functions within the developing vertebrate brain. In this article, the role of miR-9 in the developing forebrain (telencephalon and diencephalon, midbrain, hindbrain, and spinal cord of vertebrate species is highlighted. In the forebrain, miR-9 is necessary for the proper development of dorsoventral telencephalon by targeting marker genes expressed in the telencephalon. It regulates proliferation in telencephalon by regulating Foxg1, Pax6, Gsh2 , and Meis2 genes. The feedback loop regulation between miR-9 and Nr2e1/Tlx helps in neuronal migration and differentiation. Targeting Foxp1 and Foxp2 , and Map1b by miR-9 regulates the radial migration of neurons and axonal development. In the organizers, miR-9 is inversely regulated by hairy1 and Fgf8 to maintain zona limitans interthalamica and midbrain-hindbrain boundary (MHB. It maintains the MHB by inhibiting Fgf signaling genes and is involved in the neurogenesis of the midbrain-hindbrain by regulating Her genes. In the hindbrain, miR-9 modulates progenitor proliferation and differentiation by regulating Her genes and Elav3. In the spinal cord, miR-9 modulates the regulation of Foxp1 and Onecut1 for motor neuron development. In the forebrain, midbrain, and hindbrain, miR-9 is necessary for proper neuronal progenitor maintenance, neurogenesis, and differentiation. In vertebrate brain development, miR-9 is involved in regulating several region-specific genes in a spatiotemporal pattern.

  3. Prognostic significance of miR-205 in endometrial cancer.

    Directory of Open Access Journals (Sweden)

    Mihriban Karaayvaz

    Full Text Available microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus, microRNAs have potential as both cancer biomarkers and/or potential novel therapeutic targets. Although accumulating evidence suggests the role of aberrant microRNA expression in endometrial carcinogenesis, there are still limited data available about the prognostic significance of microRNAs in endometrial cancer. The goal of this study is to investigate the prognostic value of selected key microRNAs in endometrial cancer by the analysis of archival formalin-fixed paraffin-embedded tissues.Total RNAs were extracted from 48 paired normal and endometrial tumor specimens using Trizol based approach. The expression of miR-26a, let-7g, miR-21, miR-181b, miR-200c, miR-192, miR-215, miR-200c, and miR-205 were quantified by real time qRT-PCR expression analysis. Targets of the differentially expressed miRNAs were quantified using immunohistochemistry. Statistical analysis was performed by GraphPad Prism 5.0.The expression levels of miR-200c (P<0.0001 and miR-205 (P<0.0001 were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival (hazard ratio, 0.377; Logrank test, P = 0.028. Furthermore, decreased expression of a miR-205 target PTEN was detected in endometrial cancer tissues compared to normal tissues.miR-205 holds a unique potential as a prognostic biomarker in endometrial cancer.

  4. Excreta Disposal in Dar-es-salaam

    NARCIS (Netherlands)

    Chaggu, E.; Mashouri, D.; Buuren, van J.C.L.; Sanders, W.T.M.; Lettinga, G.

    2002-01-01

    The sociocultural and socioeconomic situation of sanitation in Dar-es-Salaam (Dsm), Tanzania, was studied with explicit emphasis on pit-latrines. Without considering the sociocultural conditions, the so-called best solution might not be the right one. Therefore, in order to achieve the intended

  5. El punto de partida es nuestra identidad

    OpenAIRE

    Alcalde, Pamela

    2016-01-01

    Néstor tiene claro que su identidad es algo primordial en su arte, desde los mantos pre incas de la cultura Paracas hasta el indigenismo con José Sabogal. Además, considera necesario tener una proyección social, buscar que la gente se sienta reflejada en sus obras.

  6. miRSponge: a manually curated database for experimentally supported miRNA sponges and ceRNAs.

    Science.gov (United States)

    Wang, Peng; Zhi, Hui; Zhang, Yunpeng; Liu, Yue; Zhang, Jizhou; Gao, Yue; Guo, Maoni; Ning, Shangwei; Li, Xia

    2015-01-01

    In this study, we describe miRSponge, a manually curated database, which aims at providing an experimentally supported resource for microRNA (miRNA) sponges. Recent evidence suggests that miRNAs are themselves regulated by competing endogenous RNAs (ceRNAs) or 'miRNA sponges' that contain miRNA binding sites. These competitive molecules can sequester miRNAs to prevent them interacting with their natural targets to play critical roles in various biological and pathological processes. It has become increasingly important to develop a high quality database to record and store ceRNA data to support future studies. To this end, we have established the experimentally supported miRSponge database that contains data on 599 miRNA-sponge interactions and 463 ceRNA relationships from 11 species following manual curating from nearly 1200 published articles. Database classes include endogenously generated molecules including coding genes, pseudogenes, long non-coding RNAs and circular RNAs, along with exogenously introduced molecules including viral RNAs and artificial engineered sponges. Approximately 70% of the interactions were identified experimentally in disease states. miRSponge provides a user-friendly interface for convenient browsing, retrieval and downloading of dataset. A submission page is also included to allow researchers to submit newly validated miRNA sponge data. Database URL: http://www.bio-bigdata.net/miRSponge. © The Author(s) 2015. Published by Oxford University Press.

  7. Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.

    Science.gov (United States)

    Ni, Bin; Rajaram, Murugesan V S; Lafuse, William P; Landes, Michelle B; Schlesinger, Larry S

    2014-11-01

    IFN-γ-activated macrophages play an essential role in controlling intracellular pathogens; however, macrophages also serve as the cellular home for the intracellular pathogen Mycobacterium tuberculosis. Based on previous evidence that M. tuberculosis can modulate host microRNA (miRNA) expression, we examined the miRNA expression profile of M. tuberculosis-infected primary human macrophages. We identified 31 differentially expressed miRNAs in primary human macrophages during M. tuberculosis infection by NanoString and confirmed our findings by quantitative real-time RT-PCR. In addition, we determined a role for two miRNAs upregulated upon M. tuberculosis infection, miR-132 and miR-26a, as negative regulators of transcriptional coactivator p300, a component of the IFN-γ signaling cascade. Knockdown expression of miR-132 and miR-26a increased p300 protein levels and improved transcriptional, translational, and functional responses to IFN-γ in human macrophages. Collectively, these data validate p300 as a target of miR-132 and miR-26a, and demonstrate a mechanism by which M. tuberculosis can limit macrophage responses to IFN-γ by altering host miRNA expression. Copyright © 2014 by The American Association of Immunologists, Inc.

  8. Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Khalda S. Amr

    2017-12-01

    Full Text Available Hepatocellular carcinoma (HCC is one of the common lethal types of tumor all over the world. The lethality of HCC accounts for many reasons. One of them, the lack of reliable diagnostic markers at the early stage, in this context, serum miRNAs became promising diagnostic biomarkers. Herein, we aimed to identify the predictive value of two miRNAs (miR-122 and miR-224 in plasma of patients with HCC preceded by chronic HCV infection. Taqman miRNA assays specific for hsa-miR-122 and hsa-miR-224 were used to assess the expression levels of the chosen miRNAs in plasma samples collected from three groups; 40 patients with HCC related to HCV, 40 with CHC patients and 20 healthy volunteers. This study revealed that the mean plasma values of miRNA-122 were significantly lower among HCC group when compared to CHC and control groups (P 1.2 (RQ and (AUC = 0.93, P < 0.001, while the accuracy of AFP to diagnose HCC was (AUC: 0.619; P = 0.06. In conclusion, the expression plasma of miR-122 and miR-224 could be used as noninvasive biomarkers for the early prediction of developing HCC at the early stage.

  9. "Este Libro Es Mi Historia": Mother-Child Interactions during Storybook Reading in a Mexican-American Household.

    Science.gov (United States)

    Manyak, Patrick

    A study explored the storybook reading experiences between Ms. Garza and her children. A broad conception of the zone of proximal development, involving use, adaptation, and transformation of culturally shaped tools in the process of shared activity, provides the framework for examining this particular Mexican-American family's reading behavior.…

  10. [Santa Casa de Misericórdia and hygienist policies in Belém do Pará in the late nineteenth century].

    Science.gov (United States)

    Miranda, Cybelle Salvador; Beltrão, Jane Felipe; Henrique, Márcio Couto; Bessa, Brena Tavares

    2015-01-01

    The article analyzes the relationship between hygienist policies in effect in Belém in the late nineteenth century and the expansion of activities of the Santa Casa de Misericórdia do Pará. Considered one of the first hospital institutions in the former Grão-Pará Province, in addition to its own hospital, the Brotherhood administered several other health facilities in the capital, and the study of its physical displacement made it possible to "map" three health centers in Belém: Pioneer, Expansion and the Santa Casa, which reinforce the growth vectors of the city. The expansion of its activities is configured as the expansion of the Santa Casa de Misericórdia to serve the underprivileged and sick, preceding the establishment of a public health system in Pará.

  11. El fresco de la casa de Iulia Felix : anatomía de una scho

    Directory of Open Access Journals (Sweden)

    Milagros Moro Ipola

    2010-01-01

    Full Text Available Antes del contacto de Roma con las ciudades griegas del sur de Italia durante la Guerra contra Pirro en el siglo III a.C., el tipo de educación que recibían los jóvenes romanos era el reflejo de la sociedad agraria que era por entonces Roma. Los hijos estaban bajo la tutela de la madre o del aya hasta los siete años, aproximadamente, cuando el padre se hacía cargo de su formación. La relación con Grecia y su cultura revolucionó el sistema educativo tradicional y la enseñanza casera y honorable, como decía Plutarco (Quest. Rom. LIX pues «la gente enseñaba sólo a sus amigos y familiares», a cargo del paterfamilias dejó paso a una otra peor valorada impartida por maestros y profesores. El conocido fresco escolar encontrado en la casa de Iulia Felix en Pomeya nos sirve de guía para descubrir ese mundo a través de una imagen.Before the contact with the Greek cities in southern Italy during the war against Pyrrhus in the IIIrd century b.C., the young Romans had a kind of upbringing that was a reflection of the agrarian society Rome was at that time. Children were a guard of the mother or the governess until they were around seven. Then, the father took charge of their training. The relationship with Greece and its culture revolutionized the traditional education system and the home and honorable upbringing in the charge of the paterfamilias, as Plutarch said, (Quest. Rom. LIX because «people only taught the friends and the relatives», gave way to another one, given by teachers and not valued by society at all. The known school fresco found in the House of Iulia Felix, in Pompeii, can serve a guide in order to discover this world through an image.

  12. MiRNA-155 and miRNA-132 as potential diagnostic biomarkers for pulmonary tuberculosis: A preliminary study.

    Science.gov (United States)

    Zheng, Meng-Li; Zhou, Nai-Kang; Luo, Cheng-Hua

    2016-11-01

    In our study, we aimed to profile a panel microRNAs (miRNAs) as potential biomarkers for the early diagnosis of pulmonary tuberculosis (PTB) and to illuminate the molecular mechanisms in the development of PTB. Firstly, gene expression profile of E-GEOD-49951 was downloaded from ArrayExpress database, and quantile-adjusted conditional maximum likelihood method was utilized to identify statistical difference between miRNAs of Mycobacterium tuberculosis (MTB)-infected individuals and healthy subjects. Furthermore, in order to assess the performance of our methodology, random forest (RF) classification model was utilized to identify the top 10 miRNAs with better Area Under The Curve (AUC) using 10-fold cross-validation method. Additionally, Monte Carlo Cross-Validation was repeated 50 times to explore the best miRNAs. In order to learn more about the differentially-expressed miRNAs, the target genes of differentially-expressed miRNAs were retrieved from TargetScan database and Ingenuity Pathways Analysis (IPA) was used to screen out biological pathways where target genes were involved. After normalization, a total of 478 miRNAs with higher than 0.25-fold quantile average across all samples were required. Based on the differential expression analysis, 38 differentially expressed miRNAs were identified when the significance was set as false discovery rate (FDR) < 0.01. Among the top 10 differentially expressed miRNAs, miRNA-155 obtained a highest AUC value 0.976, showing a good performance between PTB and control groups. Similarly, miRNA-449a, miRNA-212 and miRNA-132 revealed also a good performance with AUC values 0.947, 0.931 and 0.930, respectively. Moreover, miRNA-155, miRNA-449a, miRNA-29b-1* and miRNA-132 appeared in 50, 49, 49 and 48 bootstraps. Thus, miRNA-155 and miRNA-132 might be important in the progression of PTB and thereby, might present potential signatures for diagnosis of PTB. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Incubation of human blood fractions leads to changes in apparent miRNA abundance

    DEFF Research Database (Denmark)

    Skovgaard, Kerstin; Jørgensen, Stine Thuen; Heegaard, Peter M. H.

    in significant changes in the abundance of miR-21, miR-155, Let-7c and Let 7f in plasma, miR-21, miR-23a and miR-150 in RBC and miR-15b, miR-126, miR155 and Let-7g in PBMC, while no change was seen in PRP and PMN. Interestingly, in the samples incubated with glass beads, no miRNAs were significantly affected...... in plasma, RBC, PBMC and PMN, while expression of miR-25, miR15a, miR-126 and miR223 was significantly changed in PRP. Thus, PRP, as the only blood fraction depended on stimulation to change its miRNA profile upon incubation. For the other fractions, stimulation either leveled out the changes induced...

  14. Characterization of miRNomes in Acute and Chronic Myeloid

    Directory of Open Access Journals (Sweden)

    Qian Xiong

    2014-04-01

    Full Text Available Myeloid leukemias are highly diverse diseases and have been shown to be associated with microRNA (miRNA expression aberrations. The present study involved an in-depth miRNome analysis of two human acute myeloid leukemia (AML cell lines, HL-60 and THP-1, and one human chronic myeloid leukemia (CML cell line, K562, via massively parallel signature sequencing. mRNA expression profiles of these cell lines that were established previously in our lab facilitated an integrative analysis of miRNA and mRNA expression patterns. miRNA expression profiling followed by differential expression analysis and target prediction suggested numerous miRNA signatures in AML and CML cell lines. Some miRNAs may act as either tumor suppressors or oncomiRs in AML and CML by targeting key genes in AML and CML pathways. Expression patterns of cell type-specific miRNAs could partially reflect the characteristics of K562, HL-60 and THP-1 cell lines, such as actin filament-based processes, responsiveness to stimulus and phagocytic activity. miRNAs may also regulate myeloid differentiation, since they usually suppress differentiation regulators. Our study provides a resource to further investigate the employment of miRNAs in human leukemia subtyping, leukemogenesis and myeloid development. In addition, the distinctive miRNA signatures may be potential candidates for the clinical diagnosis, prognosis and treatment of myeloid leukemias.

  15. Encontros musicais como recurso em cuidados paliativos oncológicos a usuários de casas de apoio

    Directory of Open Access Journals (Sweden)

    Vladimir Araujo da Silva

    2013-06-01

    Full Text Available Investigação fenomenológica, estruturada na analítica existencial de Heidegger, que objetivou desvelar a percepção de usuários que vivenciam o câncer em uma casa de apoio, em relação aos encontros musicais. Participaram do estudo sete usuários da casa de apoio da Rede Feminina de Combate ao Câncer de Maringá, onde foram realizados oito encontros musicais, durante os meses de janeiro e fevereiro de 2011. Para a coleta de dados foi utilizada a entrevista individual, conduzida pela seguinte questão norteadora: o que esses encontros musicais representam para você neste momento de sua vida? Durante o processo de compreensão do fenômeno investigado, emergiram duas temáticas ontológicas - Sentindo-se cuidado nos encontros musicais e Transcendendo sua facticidade existencial. Constatou-se que o encontro mediado pela música constitui um recurso no cuidado de enfermagem em cuidados paliativos oncológicos, que inspira vida aos dias dos usuários, imprimindo-lhes a sensação de cuidado e ressignificando seu existir-no-mundo.

  16. Using African languages for democracy and lifelong learning in Africa: A post-2015 challenge and the work of CASAS

    Science.gov (United States)

    Brock-Utne, Birgit; Mercer, Malcolm

    2014-12-01

    Africans speak African languages in their everyday lives while lessons in school are delivered in an exogenous language. In many places adult education is also carried out in a language the majority of people do not speak. The exogenous languages, which are the languages of the former colonial powers and mastered just by a small African elite, are used in most parliaments in Africa and in most newspapers. This problem is largely ignored by the international community. An argument often put forward against using African languages as Languages of Instruction (LOIs) is that there are so many of them, and it may be problematic to select one as an LOI. But is this really the case? And does one need to select one language? The main work of the Centre for Advanced Studies of African Society (CASAS) located in Cape Town has been to harmonise the written forms of most African languages so that these languages can be used as LOIs and as languages of government and the press. This paper examines in some detail the work undertaken by CASAS, its successes and challenges. It shows that the political process of getting the harmonised languages adopted is more difficult and unpredictable than the linguistic work itself.

  17. Validation of the sperm class analyser CASA system for sperm counting in a busy diagnostic semen analysis laboratory.

    Science.gov (United States)

    Dearing, Chey G; Kilburn, Sally; Lindsay, Kevin S

    2014-03-01

    Sperm counts have been linked to several fertility outcomes making them an essential parameter of semen analysis. It has become increasingly recognised that Computer-Assisted Semen Analysis (CASA) provides improved precision over manual methods but that systems are seldom validated robustly for use. The objective of this study was to gather the evidence to validate or reject the Sperm Class Analyser (SCA) as a tool for routine sperm counting in a busy laboratory setting. The criteria examined were comparison with the Improved Neubauer and Leja 20-μm chambers, within and between field precision, sperm concentration linearity from a stock diluted in semen and media, accuracy against internal and external quality material, assessment of uneven flow effects and a receiver operating characteristic (ROC) analysis to predict fertility in comparison with the Neubauer method. This work demonstrates that SCA CASA technology is not a standalone 'black box', but rather a tool for well-trained staff that allows rapid, high-number sperm counting providing errors are identified and corrected. The system will produce accurate, linear, precise results, with less analytical variance than manual methods that correlate well against the Improved Neubauer chamber. The system provides superior predictive potential for diagnosing fertility problems.

  18. Minha casa, minha vida: extensão do direito à moradia e proteção constitucional

    Directory of Open Access Journals (Sweden)

    Guilherme Domingos de Luca

    2016-04-01

    Full Text Available O trabalho em questão busca analisar o Direito à moradia sob a ótica do Programa “Minha Casa, Minha Vida”. Demonstrará as ações do Estado visando a Regularização Fundiária, em face do interesse social no combate ao déficit imobiliário, além de analisar as hipóteses de perda do imóvel. O objetivo geral do estudo é compreender se há efetividade no direito à moradia a partir da vinculação ao Programa “Minha Casa, Minha Vida”, instituído pelo advento da Lei n° 11.977/09. De forma específica, o objetivo será entender o direito do indivíduo em adquirir novo imóvel, mesmo que em determinado momento teve de dispor de outro imóvel adquirido pelo Programa em questão. Trata-se de uma pesquisa pautada no método de investigação dedutivo, cujos procedimentos técnicos adotados foram livros, doutrinas, leis e jurisprudência. Com efeito, parte-se de um estudo bibliográfico e jurídico, para a posterior abordagem do atual contexto legislativo brasileiro mediante a adoção de um ponto de partida constitucional.

  19. The Casa Pizano and the Construction of Light Vaults in Colombia. The Origin of a Modern Tradition

    Directory of Open Access Journals (Sweden)

    Julián García

    2018-05-01

    Full Text Available At the beginning of the 20th Century several buildings were covered with tile vaults all through Latin America. However, two houses designed and built by Le Corbusier (the Maisons Sarabhai (Ahmadabad 1955 and Jaoul (Paris 1955 have traditionally been considered the main influence for later vaulted buildings covered with this technique in the area in the 60s and 70s. Since there were built examples contemporary or previous to the buildings by the Swiss architect, it seems logical to think that the influence of the Jaoul or Sarabhai houses in Latin American vault construction might have been somehow less relevant. There are several examples that support that idea: the most relevant is the Casa Pizano, a missing Bogota building designed by the local architect Francisco Pizano de Brigard, which was Le Corbusier's main inspiration for the aforementioned houses. The hypothesis of this paper is that local networks were also essential in the task of connecting similar technical initiatives regarding vault construction. To verify this hypothesis, several examples of buildings from different Latin American countries, starting from the Casa Pizano, will be studied, and some possible contacts between architects will be proposed.

  20. Evaluación del comportamiento sísmico de casas consistoriales de tapia pisada reforzadas con maderas de confinamiento

    OpenAIRE

    Ruiz, D; Silva, M; Cerón, L; López, C

    2017-01-01

    Existen pocos estudios del comportamiento de estructuras históricas en adobe y tapia pisada en Latinoamerica, lo que ha contribuido al deterioro de estas construcciones, que son patrimonio arquitectónico y cultural. Colombia tiene el 90% de sus edificios patrimoniales en tierra y la mayoría de ellos están ubicadas en zonas riesgo sísmico alto e intermedio. Las casas consistoriales de la época colonial (casas de ayuntamiento hechas en adobe o tapia pisada) son parte de este patrimonio arquitec...

  1. La “casa de la amistad”: Modos de construir y significar el hogar propio en jóvenes de la Ciudad de Buenos Aires

    OpenAIRE

    Felice, Magdalena

    2017-01-01

    Resumen: Este artículo analiza, desde una estrategia cualitativa-interpretativa, las experiencias de construcción de un hogar propio en jóvenes de sectores medios de la Ciudad de Buenos Aires que se fueron a vivir con amigos. Entre los resultados, se destaca que los amigos constituyen un soporte afectivo fundamental, en tanto la asociación con los pares permite afrontar el desafío de irse de la casa familiar de origen y construir un hogar propio. A su vez, la “casa de la amistad” se presenta ...

  2. Internacionalização em Parceria: Construção de Casas Pré-Fabricadas em Moçambique

    OpenAIRE

    Vaz Figueiredo , César Augusto

    2017-01-01

    Neste mercado competitivo e dinâmico, as casas pré-fabricadas surgem como uma alternativa, tanto no mercado português, como nos mercados internacionais, às casas de fabrico convencional. A capacidade de serem mais acessíveis, resistentes, flexíveis de acordo com as necessidades dos clientes, com uma elevada eficiência energética e rápidas a nível da sua construção/montagem, têm sido os fatores de sucesso ao longo dos tempos. O projeto em questão tem como finalidade principal...

  3. Desenvolvimento de uma rede de sensores sem fio aplicada no monitoramento da variabilidade térmica em casas de vegetação

    OpenAIRE

    Barbosa, Rogério Zanarde [UNESP

    2015-01-01

    Este é um trabalho de tecnologia computacional aplicada na área agrícola, cujo objetivo principal do trabalho é desenvolver uma rede de sensores sem fio, que envolve aspectos de software e hardware, para o monitoramento térmico no interior de uma casa de vegetação. Além da rede propriamente dita, o trabalho também inclui a sua aplicação no levantamento quantitativo da variabilidade térmica na casa de vegetação o que pode ser aplicado em diversas atividades agrícolas a serem desenvolvidas no i...

  4. Ansiedad, depresión y síntomas psicosomáticos en una muestra de amas de casa

    OpenAIRE

    Ma. Pilar Matud; Juan Manuel Bethencourt

    2000-01-01

    En este estudio se analizan las variables más relevantes relacionadas con ansiedad, depresión y síntomas somáticos en una muestra de 180 amas de casa residentes en las Islas Canarias (España). En la predicción de la puntuación en depresión surgieron cinco predictores que explican el 44% de la variabilidad en síntomas depresivos. Las amas de casa que están más deprimidas son las de menor autoestima y apoyo social, las que se caracterizan por menor competitividad y hostilidad y las menos sat...

  5. Cuerpo y casa : hacia el espacio doméstico contemporáneo desde las transformaciones de la cocina y el cuarto de baño

    OpenAIRE

    Pardo Díaz, Gonzalo

    2016-01-01

    Los ámbitos vinculados tanto a la preparación de los alimentos como al cuidado del cuerpo revelan las transformaciones de la domesticidad a lo largo de la historia y permiten analizar los cambios más radicales de la casa y sus habitantes. Desde las primeras hogueras, el cocinar ha implicado un lugar, que una vez vinculado al habitar construido ha ido desplazándose por el espacio doméstico, ampliándose y reduciéndose, alejándose o acercándose al resto de los espacios de la casa en función de ...

  6. Education and Outreach through Ludo-Pedagogy and Experiential Learning. Bridging Feminist and Diversity Movements in Today's Nicaragua: An Interview with Helen Alfaro, Yova Briones, and Tannia Rizo Lazo of La Casa de los Colores

    Science.gov (United States)

    DeGrave, Analisa

    2016-01-01

    La Casa de los Colores (the House of Colors) is a feminist organization dedicated to defending human rights, particularly those of the LGBTQ+ community in León, Nicaragua. In 2016 Helen Alfaro, Yova Briones, Ani Guerrero, and Tannia Rizo Lazo, four members of La Casa's leadership team, "Las Coloras," were invited to speak about…

  7. Una vuelta a la “casa bonita”. Un bricolage interpretativo de las fuentes documentales sobre los rituales de menarquía de los pueblos originarios de la Patagonia argentina (Siglos XIX y XX

    Directory of Open Access Journals (Sweden)

    Graciela Hernández

    2015-12-01

    Full Text Available El principal objetivo de este trabajo es proponer un nuevo análisis del texto del británico Georges Musters, de su descripción de una ceremonia de menarquía (a la que denominó “casa bonita” observada entre tehuelches de la Patagonia en 1869, para contextualizarla históricamente y desde una perspectiva de género.Desde la metodología cualitativa hemos armado un bricolage que se expresa en un recorrido articulado por una genealogía de fuentes documentales del siglo XIX, por testimonios producidos en trabajos antropológicos y lingüísticos en la segunda mitad del siglo XX, y por registros etnográficos de nuestros trabajos en historia oral que focalizan en  rituales para propiciar el hilado.La triangulación de fuentes de los documentos seleccionados nos lleva a pensar en la hipótesis que en las ceremonias de primera menstruación, del siglo XIX en adelante, se propiciaba el apego al hilado y tejido,  en sociedades que también  ritualizaron toda la esfera del trabajo textil.

  8. Novel Triazole linked 2-phenyl benzoxazole derivatives induce apoptosis by inhibiting miR-2, miR-13 and miR-14 function in Drosophila melanogaster.

    Science.gov (United States)

    Mondal, Tanmoy; Lavanya, A V S; Mallick, Akash; Dadmala, Tulshiram L; Kumbhare, Ravindra M; Bhadra, Utpal; Bhadra, Manika Pal

    2017-06-01

    Apoptosis is an important phenomenon in multi cellular organisms for maintaining tissue homeostasis and embryonic development. Defect in apoptosis leads to a number of disorders like- autoimmune disorder, immunodeficiency and cancer. 21-22 nucleotides containing micro RNAs (miRNAs/miRs) function as a crucial regulator of apoptosis alike other cellular pathways. Recently, small molecules have been identified as a potent inducer of apoptosis. In this study, we have identified novel Triazole linked 2-phenyl benzoxazole derivatives (13j and 13h) as a negative regulator of apoptosis inhibiting micro RNAs (miR-2, miR-13 and miR-14) in a well established in vivo model Drosophila melanogaster where the process of apoptosis is very similar to human apoptosis. These compounds inhibit miR-2, miR-13 and miR-14 activity at their target sites, which induce an increased caspase activity, and in turn influence the caspase dependent apoptotic pathway. These two compounds also increase the mitochondrial reactive oxygen species (ROS) level to trigger apoptotic cell death.

  9. miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments.

    Science.gov (United States)

    Hackenberg, Michael; Sturm, Martin; Langenberger, David; Falcón-Pérez, Juan Manuel; Aransay, Ana M

    2009-07-01

    Next-generation sequencing allows now the sequencing of small RNA molecules and the estimation of their expression levels. Consequently, there will be a high demand of bioinformatics tools to cope with the several gigabytes of sequence data generated in each single deep-sequencing experiment. Given this scene, we developed miRanalyzer, a web server tool for the analysis of deep-sequencing experiments for small RNAs. The web server tool requires a simple input file containing a list of unique reads and its copy numbers (expression levels). Using these data, miRanalyzer (i) detects all known microRNA sequences annotated in miRBase, (ii) finds all perfect matches against other libraries of transcribed sequences and (iii) predicts new microRNAs. The prediction of new microRNAs is an especially important point as there are many species with very few known microRNAs. Therefore, we implemented a highly accurate machine learning algorithm for the prediction of new microRNAs that reaches AUC values of 97.9% and recall values of up to 75% on unseen data. The web tool summarizes all the described steps in a single output page, which provides a comprehensive overview of the analysis, adding links to more detailed output pages for each analysis module. miRanalyzer is available at http://web.bioinformatics.cicbiogune.es/microRNA/.

  10. miR-181a and miR-630 regulate cisplatin-induced cancer cell death.

    Science.gov (United States)

    Galluzzi, Lorenzo; Morselli, Eugenia; Vitale, Ilio; Kepp, Oliver; Senovilla, Laura; Criollo, Alfredo; Servant, Nicolas; Paccard, Caroline; Hupé, Philippe; Robert, Thomas; Ripoche, Hugues; Lazar, Vladimir; Harel-Bellan, Annick; Dessen, Philippe; Barillot, Emmanuel; Kroemer, Guido

    2010-03-01

    MicroRNAs (miRNA) are noncoding RNAs that regulate multiple cellular processes, including proliferation and apoptosis. We used microarray technology to identify miRNAs that were upregulated by non-small cell lung cancer (NSCLC) A549 cells in response to cisplatin (CDDP). The corresponding synthetic miRNA precursors (pre-miRNAs) per se were not lethal when transfected into A549 cells yet affected cell death induction by CDDP, C2-ceramide, cadmium, etoposide, and mitoxantrone in an inducer-specific fashion. Whereas synthetic miRNA inhibitors (anti-miRNAs) targeting miR-181a and miR-630 failed to modulate the response of A549 to CDDP, pre-miR-181a and pre-miR-630 enhanced and reduced CDDP-triggered cell death, respectively. Pre-miR-181a and pre-miR-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including Bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. In addition, pre-miR-630 blocked early manifestations of the DNA damage response, including the phosphorylation of the ataxia-telangiectasia mutated (ATM) kinase and of two ATM substrates, histone H2AX and p53. Pharmacologic and genetic inhibition of p53 corroborated the hypothesis that pre-miR-630 (but not pre-miR-181a) blocks the upstream signaling pathways that are ignited by DNA damage and converge on p53 activation. Pre-miR-630 arrested A549 cells in the G0-G1 phase of the cell cycle, correlating with increased levels of the cell cycle inhibitor p27(Kip1) as well as with reduced proliferation rates and resulting in greatly diminished sensitivity of A549 cells to the late S-G2-M cell cycle arrest mediated by CDDP. Altogether, these results identify miR-181a and miR-630 as novel modulators of the CDDP response in NSCLC.

  11. The Origins of dEs

    Science.gov (United States)

    Skillman, Evan D.

    With the new discoveries that some dEs are rotationally supported and that dIs may show a large variety in star formation histories, the perceived relationships between these two families of galaxies are changing. There are at least three viable channels for the origin of dwarf elliptical galaxies with strong observational evidence that support their reality. I will discuss the observational evidence for each of these channels and the likely physical processes which determine each channel.

  12. ¿Que es TeleSUR?

    Directory of Open Access Journals (Sweden)

    Carlos Arcila Calderón

    2014-12-01

    Full Text Available Telesur nace en el seno de proyecto político, de resistencia contra el orden mundial actual, en el convencimiento de que la comunicación es capaz de lograr metas importantes en los procesos de cohesión de las sociedades. El desafío fue crear un medio de comunicación independiente de las empresas comerciales.

  13. The expression of miR-181a-5p and miR-371b-5p in chondrosarcoma.

    Science.gov (United States)

    Mutlu, S; Mutlu, H; Kirkbes, S; Eroglu, S; Kabukcuoglu, Y S; Kabukcuoglu, F; Duymus, T M; ISık, M; Ulasli, M

    2015-07-01

    Chondrosarcomas are malignant tumors of chondrocytes that affect bones and joints, and it represents the third most common type of primary bone tumors. Chondrosarcoma is difficult to treat because it is relatively resistant to both chemotherapy and radiation. Thus, surgery remains the best available treatment. It is important to find new diagnostic markers and improve treatment options. miRNAs are small non-coding transcripts (19-25 nucleotides) that regulate gene expression via targeting complementary sequences within messenger RNAs (mRNAs). miRNAs have been shown to be involved in regulation of many biochemical pathways. Dysregulated expression of many miRNAs has also been associated with multiple human diseases, such as cancer. 18 surgical chondrosarcoma specimens were obtained from patients. RNA extractions were performed from decalcified paraffin embedded tissues. The aim of this study was to investigate the expression levels of miR-181a and miR-371b in patients with chondrosarcoma by using RT-PCR and to evaluate the relationship between these miRNAs and chondrosarcoma. miR-181a was found to be upregulated in chondrosarcoma specimens whereas no significant alteration was found for miR-371b expression. It has been proposed that miRNA expression studies might be used as diagnostic, prognostic marker in cancer. miRNA expression data produced in our study may contribute future chondrosarcoma diagnosis and therapy.

  14. Integrating miRNA and mRNA Expression Profiling Uncovers miRNAs Underlying Fat Deposition in Sheep

    Directory of Open Access Journals (Sweden)

    Guangxian Zhou

    2017-01-01

    Full Text Available MicroRNAs (miRNAs are endogenous, noncoding RNAs that regulate various biological processes including adipogenesis and fat metabolism. Here, we adopted a deep sequencing approach to determine the identity and abundance of miRNAs involved in fat deposition in adipose tissues from fat-tailed (Kazakhstan sheep, KS and thin-tailed (Tibetan sheep, TS sheep breeds. By comparing HiSeq data of these two breeds, 539 miRNAs were shared in both breeds, whereas 179 and 97 miRNAs were uniquely expressed in KS and TS, respectively. We also identified 35 miRNAs that are considered to be putative novel miRNAs. The integration of miRNA-mRNA analysis revealed that miRNA-associated targets were mainly involved in the gene ontology (GO biological processes concerning cellular process and metabolic process, and miRNAs play critical roles in fat deposition through their ability to regulate fundamental pathways. These pathways included the MAPK signaling pathway, FoxO and Wnt signaling pathway, and focal adhesion. Taken together, our results define miRNA expression signatures that may contribute to fat deposition and lipid metabolism in sheep.

  15. Návrh kmitočtových filtrů s netradičními aktivními prvky

    OpenAIRE

    Jarník, Lukáš

    2013-01-01

    Táto bakalárska práca je zameraná na návrh kmitočtových filtrov s netradičnými aktívnymi prvkami. Sú tu prezentované aktívne prvky ako sú prúdové konvejory (GCC), napäťové konvejory (GVC), transkonduktančné zosilovače (OTA, CFTA), ktoré pracujú v prúdovom režime. V práci je ďalej navrhnutých a odsimulovaných šesť zapojení s aktívnymi prvkami (GCC), (CFTA), (OTA) a (GVC), ktoré vychádzaju z návrhu podla úplnej admitančnej siete. Jedno zapojenie bolo prakticky zrealizované a experimentálne over...

  16. ¿Qué es conducta?

    Directory of Open Access Journals (Sweden)

    Esteve Freixa i Baqué

    2003-01-01

    Full Text Available La definición de la Psicología como ciencia de la conducta adoptada por el Conductismo supone e implica a su vez una conceptualización clara y unívoca de dicho concepto. Pero tal definición se enfrenta con una serie de malentendidos tenaces que dificultan no sólo la comprensión de dicho concepto básico sino también, en consecuencia, la propia conceptualización conductista. El propósito del presente trabajo es intentar exponer algunos de estos malentendidos, entre los que destacan los errores categoriales groseros, los procesos de reificación abusiva, los razonamientos tautológicos disfrazados, la generalización imprudente del modelo médico al ámbito de la conducta y la confusión nefasta entre un fenómeno y su conceptualización. Para ello, y con un tono más didáctico que académico, se recurre a una serie de metáforas de la vida cotidiana: la parte escondida del iceberg no es más que iceberg, las piedras no caen por su propio peso, los hombres y las mujeres no mueren porque son mortales, el bacilo de Koch existe y la máscara no es el rostro.

  17. Investigation of low pressure ES-SAGD

    Energy Technology Data Exchange (ETDEWEB)

    Ivory, J.; Zheng, R.; Nasr, T.; Deng, X.; Beaulieu, G.; Heck, G. [Alberta Research Council, Edmonton, AB (Canada)

    2008-10-15

    This paper described a scaled model experiment conducted to investigate the effectiveness of expanding solvent steam assisted gravity drainage (ES-SAGD) processes at low pressures. Lower SAGD pressures typically result in reduced oil production as a result of correspondingly lower steam temperatures. However, lower pressures may also result in a reduced steam to oil ratio (SOR) and a higher vaporization heat. Steam was injected into an injection well at 33 cm{sup 3} per minute and in a production well at 31 cm{sup 3} per minute. Steam and solvents were then co-injected into the injection well at a temperature of 206 degrees C. The experiment was history-matched and a parametric analysis was conducted using a simulation tool. The 2-D and 3-D field-scale simulations investigated the impact of operating pressures, injection rates; sub-cool; oil and gas phase diffusion and dispersion; live oil versus dead oil performance; and the use of drawdown when oil rates declined. Low pressure ES-SAGD was then compared with low-pressure SAGD. Results of the study suggested that production pressures, sub-cool and solvent concentrations are important parameters in ES-SAGD processes. At 1500 kPa production pressure and 10 degrees C sub-cool, the co-injection of solvent with steam increased average oil rates by 15 per cent more than the SAGD process. SOR was also reduced. 6 refs., 8 tabs., 20 figs.

  18. The role of miRNAs in endometrial cancer.

    Science.gov (United States)

    Vasilatou, Diamantina; Sioulas, Vasileios D; Pappa, Vasiliki; Papageorgiou, Sotirios G; Vlahos, Nikolaos F

    2015-01-01

    miRNAs are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Since their discovery, miRNAs have been associated with every cell function including malignant transformation and metastasis. Endometrial cancer is the most common gynecologic malignancy. However, improvement should be made in interobserver agreement on histological typing and individualized therapeutic approaches. This article summarizes the role of miRNAs in endometrial cancer pathogenesis and treatment.

  19. Prevalência da retinopatia diabética no Ambulatório de Endocrinologia Pediátrica da Santa Casa de Misericórdia de São Paulo The prevalence of diabetic retinopathy at the Pediatric Endocrinology Outpatient Clinic of the Santa Casa de São Paulo

    Directory of Open Access Journals (Sweden)

    Daniel de Souza Pereira

    2004-02-01

    Full Text Available OBJETIVO: Verificar a prevalência de retinopatia diabética encontrada na população de diabéticos tipo 1, acompanhada no Ambulatório de Endocrinologia Pediátrica da Santa Casa de Misericórdia de São Paulo, entre 29 de agosto de 2000 e 17de agosto de 2001, e sua relação com o sexo, a idade do paciente na ocasião do diagnóstico do diabete e a duração do diabete. MÉTODO: Foi realizado mapeamento de retina, biomicroscopia de fundo e retinografia em 81 pacientes, 41 do sexo feminino e 40 do masculino, a fim de detectar e classificar a retinopatia diabética nessa população. RESULTADOS: A idade dos pacientes variou entre 4 e 23 anos (média = 12,0 ± 12,0, a idade do paciente na ocasião do diagnóstico, entre 6 meses e 15 anos (média = 3,4 ± 5,8 e a duração do diabete, entre 7 meses e 20 anos (média = 5,8 ± 4,4. A retinopatia diabética foi observada em 14 pacientes (17,3%, 7 (8,6% com a forma não proliferativa muito leve, 5 (6,2% com forma não proliferativa leve, 1 (1,2% com forma proliferativa de alto risco e 1 (1,2% com forma proliferativa avançada. CONCLUSÕES: A prevalência da retinopatia diabética na nossa amostra é 17,3%. Não há diferença entre os portadores e não portadores de retinopatia diabética quanto a sexo e idade do paciente na ocasião do diagnóstico. Quanto maior a duração da diabete, maior a prevalência da retinopatia diabética.PURPOSE: To verify the prevalence of diabetic retinopathy found in a type I diabetic population, accompanied at the Pediatric Endocrinology Outpatient Clinic of the "Santa Casa de Misericórdia de São Paulo", between August 29, 2000 and August 17, 2001, and it's relationship with sex, the patient's age on occasion of the diagnosis of diabetes and the duration of diabetes. METHODS: Retinal mappings, biomicroscopic fundus and retinography were accomplished in 81 patients, 41 female and 40 male, in order to detect and to classify the diabetic retinopathies in that

  20. Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 Increases Neovascularization and Blood Flow Recovery After Ischemia

    DEFF Research Database (Denmark)

    Welten, S. M. J.; Bastiaansen, Ajnm; de Jong, R. C. M.

    2014-01-01

    in mice after single femoral artery ligation. Methods and Results: Gene silencing oligonucleotides (GSOs) were used to inhibit 4 14q32 microRNAs, miR-329, miR-487b, miR-494, and miR-495, 1 day before double femoral artery ligation. Blood flow recovery was followed by laser Doppler perfusion imaging. All 4...... GSOs clearly improved blood flow recovery after ischemia. Mice treated with GSO-495 or GSO-329 showed increased perfusion already after 3 days (30% perfusion versus 15% in control), and those treated with GSO-329 showed a full recovery of perfusion after 7 days (versus 60% in control). Increased...

  1. Isolation and Identification of miRNAs in Jatropha curcas

    Science.gov (United States)

    Wang, Chun Ming; Liu, Peng; Sun, Fei; Li, Lei; Liu, Peng; Ye, Jian; Yue, Gen Hua

    2012-01-01

    MicroRNAs (miRNAs) are small noncoding RNAs that play crucial regulatory roles by targeting mRNAs for silencing. To identify miRNAs in Jatropha curcas L, a bioenergy crop, cDNA clones from two small RNA libraries of leaves and seeds were sequenced and analyzed using bioinformatic tools. Fifty-two putative miRNAs were found from the two libraries, among them six were identical to known miRNAs and 46 were novel. Differential expression patterns of 15 miRNAs in root, stem, leave, fruit and seed were detected using quantitative real-time PCR. Ten miRNAs were highly expressed in fruit or seed, implying that they may be involved in seed development or fatty acids synthesis in seed. Moreover, 28 targets of the isolated miRNAs were predicted from a jatropha cDNA library database. The miRNA target genes were predicted to encode a broad range of proteins. Sixteen targets had clear BLASTX hits to the Uniprot database and were associated with genes belonging to the three major gene ontology categories of biological process, cellular component, and molecular function. Four targets were identified for JcumiR004. By silencing JcumiR004 primary miRNA, expressions of the four target genes were up-regulated and oil composition were modulated significantly, indicating diverse functions of JcumiR004. PMID:22419887

  2. Exosomes as miRNA Carriers: Formation–Function–Future

    Science.gov (United States)

    Yu, Xiaojie; Odenthal, Margarete; Fries, Jochen W. U.

    2016-01-01

    Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine. PMID:27918449

  3. Exosomes as miRNA Carriers: Formation–Function–Future

    Directory of Open Access Journals (Sweden)

    Xiaojie Yu

    2016-12-01

    Full Text Available Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs. miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.

  4. Viruses and miRNAs: More Friends than Foes.

    Science.gov (United States)

    Bruscella, Patrice; Bottini, Silvia; Baudesson, Camille; Pawlotsky, Jean-Michel; Feray, Cyrille; Trabucchi, Michele

    2017-01-01

    There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses. Most times host miRNAs play a role in viral life-cycles and promote infection through complex regulatory pathways. miRNAs can also be encoded by a viral genome and be expressed in the host cell. Viral miRNAs can share common sequences with host miRNAs or have totally different sequences. They can regulate a variety of biological processes involved in viral infection, including apoptosis, evasion of the immune response, or modulation of viral life-cycle phases. Overall, virus/miRNA pathway interaction is defined by a plethora of complex mechanisms, though not yet fully understood. This article review summarizes recent advances and novel biological concepts related to the understanding of miRNA expression, control and function during viral infections. The article also discusses potential therapeutic applications of this particular host-pathogen interaction.

  5. Assay reproducibility in clinical studies of plasma miRNA.

    Directory of Open Access Journals (Sweden)

    Jonathan Rice

    Full Text Available There are increasing reports of plasma miRNAs as biomarkers of human disease but few standards in methodologic reporting, leading to inconsistent data. We systematically reviewed plasma miRNA studies published between July 2013-June 2014 to assess methodology. Six parameters were investigated: time to plasma extraction, methods of RNA extraction, type of miRNA, quantification, cycle threshold (Ct setting, and methods of statistical analysis. We compared these data with a proposed standard methodologic technique. Beginning with initial screening for 380 miRNAs using microfluidic array technology and validation in an additional cohort of patients, we compared 11 miRNAs that exhibited differential expression between 16 patients with benign colorectal neoplasms (advanced adenomas and 16 patients without any neoplasm (controls. Plasma was isolated immediately, 12, 24, 48, or 72 h following phlebotomy. miRNA was extracted using two different techniques (Trizol LS with pre-amplification or modified miRNeasy. We performed Taqman-based RT-PCR assays for the 11 miRNAs with subsequent analyses using a variable Ct setting or a fixed Ct set at 0.01, 0.03, 0.05, or 0.5. Assays were performed in duplicate by two different operators. RNU6 was the internal reference. Systematic review yielded 74 manuscripts meeting inclusion criteria. One manuscript (1.4% documented all 6 methodological parameters, while < 5% of studies listed Ct setting. In our proposed standard technique, plasma extraction ≤12 h provided consistent ΔCt. miRNeasy extraction yielded higher miRNA concentrations and fewer non-expressed miRNAs compared to Trizol LS (1/704 miRNAs [0.14%] vs 109/704 miRNAs [15%], not expressed, respectively. A fixed Ct bar setting of 0.03 yielded the most reproducible data, provided that <10% miRNA were non-expressed. There was no significant intra-operator variability. There was significant inter-operator variation using Trizol LS extraction, while this was

  6. Koncept oblikovne zasnove multifunkcionalne miške

    OpenAIRE

    Jelenko, Matic

    2016-01-01

    Diplomsko delo opisuje oblikovno zasnovo multifunkcijske miške, katere oblika temelji na združitvi klasične računalniški miške ter 3D miške. Predstavljena je raziskava zgodovine računalniške miške ter proces razvoja od ideje do prototipa. Rezultat je fizični model realne velikosti, narejen z načinom hitre izdelave prototipov. Dodana vrednost je dosežena z implikacijo grafično dekorativne podobe.

  7. Tissue-dependent paired expression of miRNAs

    OpenAIRE

    Ro, Seungil; Park, Chanjae; Young, David; Sanders, Kenton M.; Yan, Wei

    2007-01-01

    It is believed that depending on the thermodynamic stability of the 5′-strand and the 3′-strand in the stem-loop structure of a precursor microRNA (pre-miRNA), cells preferentially select the less stable one (called the miRNA or guide strand) and destroy the other one (called the miRNA* or passenger strand). However, our expression profiling analyses revealed that both strands could be co-accumulated as miRNA pairs in some tissues while being subjected to strand selection in other tissues. Ou...

  8. Methylation of miRNA genes and oncogenesis.

    Science.gov (United States)

    Loginov, V I; Rykov, S V; Fridman, M V; Braga, E A

    2015-02-01

    Interaction between microRNA (miRNA) and messenger RNA of target genes at the posttranscriptional level provides fine-tuned dynamic regulation of cell signaling pathways. Each miRNA can be involved in regulating hundreds of protein-coding genes, and, conversely, a number of different miRNAs usually target a structural gene. Epigenetic gene inactivation associated with methylation of promoter CpG-islands is common to both protein-coding genes and miRNA genes. Here, data on functions of miRNAs in development of tumor-cell phenotype are reviewed. Genomic organization of promoter CpG-islands of the miRNA genes located in inter- and intragenic areas is discussed. The literature and our own results on frequency of CpG-island methylation in miRNA genes from tumors are summarized, and data regarding a link between such modification and changed activity of miRNA genes and, consequently, protein-coding target genes are presented. Moreover, the impact of miRNA gene methylation on key oncogenetic processes as well as affected signaling pathways is discussed.

  9. Trinta dias na casa de tiros: o estranho caso do Dr. Edmund Forster e Adolf Hitler

    OpenAIRE

    Lewis,David

    2006-01-01

    Em 1918, em um hospital militar da reserva situado na pequena cidade pomerânia de Pasewalk, o neuropsiquiatra Prof. Edmund Forster tratou de um cabo austríaco chamado Adolf Hitler, que apresentava uma neurose de guerra (cegueira histérica), utilizando-se de técnicas terapêuticas sugestivas. Logo após a ascensão de Hitler ao poder na Alemanha nazista, em 1933, o Prof. Forster reuniu-se com um grupo de escritores alemães exilados em Paris e secretamente passou a eles informações sobre o caso. O...

  10. BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer.

    Science.gov (United States)

    Sugio, Asuka; Iwasaki, Masahiro; Habata, Shutaro; Mariya, Tasuku; Suzuki, Miwa; Osogami, Hiroyuki; Tamate, Masato; Tanaka, Ryoichi; Saito, Tsuyoshi

    2014-09-01

    Ovarian cancer is the leading cause of death from gynecologic cancer, reflecting its often late diagnosis and its chemoresistance. We identified a set of microRNAs whose expression is altered upon BAG3 knockdown. Our primary objective was to examine the relationships between BAG3, miR-29b and Mcl-1, an antiapoptotic Bcl-2 family protein, in ovarian cancer cells. Ovarian cancer cells were cultured and their responsiveness to paclitaxel was tested. Microarray analysis was performed to identify microRNAs differentially expressed in ES2 BAG3 knockdown ovarian cancer cells and their control cells. Primary ovarian cancer tissues were obtained from 56 patients operated on for ovarian cancer. The patients' clinical and pathological data were obtained from their medical records. BAG3 knockdown increased the chemosensitivity to paclitaxel of ES2 ovarian clear cell carcinoma cells to a greater degree than AMOC2 serous adenocarcinoma cells. qRT-PCR analysis showed that miR-29b expression was significantly upregulated in primary cancer tissue expressing low levels of BAG3, as compared to tissue expressing high levels. Moreover, levels of miR-29b correlated significantly with progression-free survival. Upregulation of miR-29b also reduced levels of Mcl-1 and sensitized ES2 cells to low-dose paclitaxel. BAG3 knockdown appears to downregulate expression of Mcl-1 through upregulation of miR-29b, thereby increasing the chemosensitivity of ovarian clear cell carcinoma cells. This suggests that BAG3 is a key determinant of the responsiveness of ovarian cancer cells, especially clear cell carcinoma, to paclitaxel and that BAG3 may be a useful therapeutic target for the treatment of ovarian cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Genome-wide miRNA screening reveals miR-310 family members negatively regulate the immune response in Drosophila melanogaster via co-targeting Drosomycin.

    Science.gov (United States)

    Li, Yao; Li, Shengjie; Li, Ruimin; Xu, Jiao; Jin, Ping; Chen, Liming; Ma, Fei

    2017-03-01

    Although innate immunity mediated by Toll signaling has been extensively studied in Drosophila melanogaster, the role of miRNAs in regulating the Toll-mediated immune response remains largely unknown. In this study, following Gram-positive bacterial challenge, we identified 93 differentially expressed miRNAs via genome-wide miRNA screening. These miRNAs were regarded as immune response related (IRR). Eight miRNAs were confirmed to be involved in the Toll-mediated immune response upon Gram-positive bacterial infection through genetic screening of 41 UAS-miRNA lines covering 60 miRNAs of the 93 IRR miRNAs. Interestingly, four out of these eight miRNAs, miR-310, miR-311, miR-312 and miR-313, are clustered miRNAs and belong to the miR-310 family. These miR-310 family members were shown to target and regulate the expression of Drosomycin, an antimicrobial peptide produced by Toll signaling. Taken together, our study implies important regulatory roles of miRNAs in the Toll-mediated innate immune response of Drosophila upon Gram-positive bacterial infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)

    Science.gov (United States)

    GAMBARI, ROBERTO; BROGNARA, ELEONORA; SPANDIDOS, DEMETRIOS A.; FABBRI, ENRICA

    2016-01-01

    MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal transition and metastasis. Several studies conclusively have demonstrated that miRNAs are deeply involved in tumor onset and progression, either behaving as tumor-promoting miRNAs (oncomiRNAs and metastamiRNAs) or as tumor suppressor miRNAs. This review focuses on the most promising examples potentially leading to the development of anticancer, miRNA-based therapeutic protocols. The inhibition of miRNA activity can be readily achieved by the use of miRNA inhibitors and oligomers, including RNA, DNA and DNA analogues (miRNA antisense therapy), small molecule inhibitors, miRNA sponges or through miRNA masking. On the contrary, the enhancement of miRNA function (miRNA replacement therapy) can be achieved by the use of modified miRNA mimetics, such as plasmid or lentiviral vectors carrying miRNA sequences. Combination strategies have been recently developed based on the observation that i) the combined administration of different antagomiR molecules induces greater antitumor effects and ii) some anti-miR molecules can sensitize drug-resistant tumor cell lines to therapeutic drugs. In this review, we discuss two additional issues: i) the combination of miRNA replacement therapy with drug administration and ii) the combination of antagomiR and miRNA replacement therapy. One of the solid results emerging from different independent studies is that miRNA replacement therapy can enhance the antitumor effects of the antitumor drugs. The second important conclusion of the reviewed studies is that the combination of anti-miRNA and miRNA replacement strategies may lead to excellent results, in terms of antitumor effects. PMID:27175518

  13. Estimation of Net Rice Production through Improved CASA Model by Addition of Soil Suitability Constant (ħα

    Directory of Open Access Journals (Sweden)

    Syed Muhammad Hassan Raza

    2018-05-01

    Full Text Available Net primary production (NPP is an important indicator of the supply of food and wood. We used a hierarchy model and real time field observations to estimate NPP using satellite imagery. Net radiation received by rice crop canopies was estimated as 27,428 Wm−2 (215.4 Wm−2 as averaged throughout the rice cultivation period (RCP, including 23,168 Wm−2 (118.3 Wm−2 as averaged as shortwave and 4260 Wm−2 (34.63 Wm−2 as averaged as longwave radiation. Soil, sensible and latent heat fluxes were approximated as 3324 Wm−2, 16,549 Wm−2, and 7554 Wm−2, respectively. Water stress on rice crops varied between 0.5838 and 0.1218 from the start until the end of the RCP. Biomass generation declined from 6.09–1.03 g/m2 in the tillering and ripening stages, respectively. We added a soil suitability constant (ħα into the Carnegie-Ames-Stanford Approach (CASA model to achieve a more precise estimate of yield. Classification results suggest that the total area under rice cultivation was 8861 km2. The spatial distribution of rice cultivation as per suitability zone was: 1674 km2 was not suitable (NS, 592 km2 was less suitable (LS, 2210 km2 was moderately suitable (MS and 4385 km2 was highly suitable (HS soil type with ħα ranges of 0.05–0.25, 0.4–0.6, 0.7–0.75 and 0.85–0.95 of the CASA based yield, respectively. We estimated net production as 1.63 million tons, as per 0.46 ton/ha, 1.2 ton/ha 1.9 ton/ha and 2.4 ton/ha from NS, LS, MS and HS soil types, respectively. The results obtained through this improved CASA model, by addition of the constant ħα, are likely to be useful for agronomists by providing more accurate estimates of NPP.

  14. miR398 and miR395 are involved in response to SO2 stress in Arabidopsis thaliana.

    Science.gov (United States)

    Li, Lihong; Yi, Huilan; Xue, Meizhao; Yi, Min

    2017-11-01

    Sulfur dioxide (SO 2 ) is a common air pollutant that has adverse effects on plants. MicroRNAs (miRNAs) are small noncoding RNA that play critical roles in plant development and stress response. In this study, we found that two miRNAs, miR398 and miR395, were differentially expressed in Arabidopsis shoots under SO 2 stress. The expression of miR398 was down-regulated, and the transcript levels of its target genes, Cu/Zn superoxide dismutases (CSD1 and CSD2), were increased during SO 2 exposure. The activity of superoxide dismutase (SOD), one of the major antioxidant enzymes, was enhanced with the increase in the CSD transcript level, suggesting an important role of miR398 in response to SO 2 -induced oxidative stress. Meanwhile, the expression of miR395 was increased, and the transcript levels of its target genes, ATP sulfurylases (APS3 and APS4) and a low-affinity sulfate transporter (SULTR2;1), were decreased in Arabidopsis shoots, showing that miR395 played important roles in the regulation of sulfate assimilation and translocation during SO 2 exposure. The content of glutathione (GSH), an important sulfur-containing antioxidant, was enhanced with the changes in sulfur metabolism in Arabidopsis shoots under SO 2 stress. These results showed that both miR398 and miR395 were involved in protecting plants from oxidative damage during SO 2 exposure. Many stress-responsive cis-elements were found in the promoter regions of MIR398 and MIR395, suggesting that these miRNAs might respond to various environmental conditions, including SO 2 stress. Overall, our study provides an insight into the regulatory roles of miRNAs in response to SO 2 stress in plants, and highlights the molecular mechanisms of plant adaptation to environmental stress.

  15. Expression patterns of miR-146a and miR-146b in mastitis infected dairy cattle.

    Science.gov (United States)

    Wang, Xing Ping; Luoreng, Zhuo Ma; Zan, Lin Sen; Raza, Sayed Haidar Abbas; Li, Feng; Li, Na; Liu, Shuan

    2016-10-01

    This study reports a significant up-regulation of bta-miR-146a and bta-miR-146b expression levels in bovine mammary tissues infected with subclinical, clinical and experimental mastitis. Potential target genes are involved in multiple immunological pathways. These results suggest a regulatory function of both miRNAs for the bovine inflammatory response in mammary tissue. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

    Science.gov (United States)

    Jimenez-Mateos, Eva M.; Bray, Isabella; Sanz-Rodriguez, Amaya; Engel, Tobias; McKiernan, Ross C.; Mouri, Genshin; Tanaka, Katsuhiro; Sano, Takanori; Saugstad, Julie A.; Simon, Roger P.; Stallings, Raymond L.; Henshall, David C.

    2011-01-01

    When an otherwise harmful insult to the brain is preceded by a brief, noninjurious stimulus, the brain becomes tolerant, and the resulting damage is reduced. Epileptic tolerance develops when brief seizures precede an episode of prolonged seizures (status epilepticus). MicroRNAs (miRNAs) are small, noncoding RNAs that function as post-transcriptional regulators of gene expression. We investigated how prior seizure preconditioning affects the miRNA response to status epilepticus evoked by intra-amygdalar kainic acid in mice. The miRNA was extracted from the ipsilateral CA3 subfield 24 hours after focal-onset status epilepticus in animals that had previously received either seizure preconditioning (tolerance) or no preconditioning (injury), and mature miRNA levels were measured using TaqMan low-density arrays. Expression of 21 miRNAs was increased, relative to control, after status epilepticus alone, and expression of 12 miRNAs was decreased. Increased miR-132 levels were matched with increased binding to Argonaute-2, a constituent of the RNA-induced silencing complex. In tolerant animals, expression responses of >40% of the injury-group-detected miRNAs differed, being either unchanged relative to control or down-regulated, and this included miR-132. In vivo microinjection of locked nucleic acid-modified oligonucleotides (antagomirs) against miR-132 depleted hippocampal miR-132 levels and reduced seizure-induced neuronal death. Thus, our data strongly suggest that miRNAs are important regulators of seizure-induced neuronal death. PMID:21945804

  17. A experiência de famílias rurais que permanecem em casas de apoio durante tratamento oncológico

    Directory of Open Access Journals (Sweden)

    Nara Marilene Oliveira Girardon-Perlini

    2017-04-01

    Full Text Available RESUMO Objetivo Compreender a experiência de famílias rurais que permanecem em casas de apoio durante o tratamento oncológico de um familiar adulto. Métodos Pesquisa qualitativa fundamentada no Interacionismo Simbólico e na pesquisa narrativa. Participaram sete famílias rurais, 14 pessoas hospedadas em casas de apoio em Santa Maria, Rio Grande do Sul, Brasil. Os dados obtidos por meio de entrevista, no período de novembro de 2010 a maio de 2011, foram analisados com ênfase no conteúdo. Resultados Os três temas abordados foram: casa de apoio como um local de referência para ficar, o cotidiano e a convivência na casa de apoio. Conclusões A experiência foi marcada pela necessidade da família adaptar-se a um contexto diferente do rural, com regras e rotinas específicas, com desconfortos e confrontos com características da cultura urbana e com o vivido por outras famílias também em situação de adoecimento, o que contribuiu para ressignificar a própria experiência.

  18. Aprendiendo en Casa: Media as a Resource for Learning among Hispanic-Latino Families. A Report of the Families and Media Project

    Science.gov (United States)

    Lee, June; Barron, Brigid

    2015-01-01

    The Hispanic-Latino population is one of the largest--and most diverse--demographics in the U.S. Aprendiendo en casa reveals findings from a national survey of Hispanic parents about their home media environments and practices, and their perceptions of their children's use of educational media across a range of different platforms. The report…

  19. "Do You Hear with Your Ears or with Your Eyes?": The Education of the Deaf Pupils at Casa Pia De Lisboa (c.1820-1950)

    Science.gov (United States)

    Martins, Catarina S.

    2009-01-01

    This paper focuses on the education of the deaf pupils at Casa Pia de Lisboa, a Portuguese boarding-school, covering the period from 1820 to 1950. The intention is to show that a historical sedimentation of a scientific discourse about deafness is an effect of a new rationality of government begun by modernity and perfectly fitting a bio-political…

  20. Computer-Assisted Sperm Analysis (CASA) parameters and their evolution during preparation as predictors of pregnancy in intrauterine insemination with frozen-thawed donor semen cycles.

    Science.gov (United States)

    Fréour, Thomas; Jean, Miguel; Mirallié, Sophie; Dubourdieu, Sophie; Barrière, Paul

    2010-04-01

    To study the potential of CASA parameters in frozen-thawed donor semen before and after preparation on silica gradient as predictors of pregnancy in IUI with donor semen cycles. CASA parameters were measured in thawed donor semen before and after preparation on a silica gradient in 132 couples undergoing 168 IUI cycles with donor semen. The evolution of these parameters throughout this process was calculated. The relationship with cycle outcome was then studied. Clinical pregnancy rate was 18.4% per cycle. CASA parameters on donor semen before or after preparation were not significantly different between pregnancy and failure groups. However, amplitude of lateral head displacement (ALH) of spermatozoa improved in all cycles where pregnancy occurred, thus predicting pregnancy with a sensitivity of 100% and a specificity of 20%. Even if CASA parameters do not seem to predict pregnancy in IUI with donor semen cycles, their evolution during the preparation process should be evaluated, especially for ALH. However, the link between ALH improvement during preparation process and pregnancy remains to be explored. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.