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Sample records for mhz acn cavities

  1. Fundamental Frequency Tuning and Its Influence on LHC 200MHz ACN Cavity

    CERN Document Server

    Linnecar, Trevor Paul R; Tückmantel, Joachim; CERN. Geneva. SPS and LHC Division

    2001-01-01

    To study the influence of the tuner on the fundamental mode frequency, the Q factor as well as the shunt impedance of the LHC 200MHz ACN cavities, 3D simulations have been done in the frequency domain using MAFIA. Curves giving the variation of RF frequency and other RF parameters with tuner position relative to the inner surface of the cavity have been obtained for the fundamental mode. This paper details the simulation results.

  2. Industrial Production of the eight normal-conducting 200 MHz ACN cavities for the LHC

    CERN Document Server

    Chiaveri, Enrico; Linnecar, Trevor Paul R; Losito, R; Marque, S; Tückmantel, Joachim

    2004-01-01

    The LHC-ACN RF system consists of 8 normalconducting cavities and is designed to reduce beam losses in the LHC when injecting beams with longitudinal emittance > 0.7 eVs from the CERN SPS. The cavity design took into account the possibility of recuperating all the "ancillary" equipment (tuners, fundamental mode damper, High Order Mode (HOM) couplers) from the old CERN SPS 200MHz system. The cavities are made from OFE copper. The original ingots, procured in Austria, have been forged and pre-formed by pressing them with a 20 tons press, following a procedure defined and adapted for the unusual dimensions of these pieces. The raw components thus obtained were machined and then welded together with an electron beam. In order to get a good repeatability of the fundamental mode frequency across the eight cavities, a procedure has been established with the contractor for the final machining and welding leading to a spread in frequencies below ±20 kHz (< 0.01%). The cavities will be installed in the LHC when l...

  3. Design of 325 MHz spoke cavity

    International Nuclear Information System (INIS)

    Sha Peng; Huang Hong; Dai Jianping; Zu Guoquan; Li Han

    2012-01-01

    Spoke cavity can be used in the low-energy section of the proton accelerator. It has many significant advantages: compact structure, high value of R/Q, etc. The ADS (Accelerator Driven System) project will adopt many spoke cavities with different β values. Therefore, IHEP has began the research of β=0.14, 325 MHz spoke cavity. In this pa per, the dimensions, RF performances and mechanical properties of it are studied. (authors)

  4. Summary of the production of the ACN cavities

    CERN Document Server

    Losito, R

    2004-01-01

    The LHC-ACN RF system consists of eight normal conducting cavities (four per beam) made of bulk copper and resonating at 200.4 MHz. CERN provided the forged copper parts to the contractor for the final machining and assembly (Ettore Zanon S.p.A., based in Schio, Italy). The contractor had to weld all the flanges to the body of the cavity, machine and weld the cooling channels, carry out the final machining to have the right geometry and the requested RF surface finish, and make the final assembly of all the components by electron beam welding. The precision required during the various steps is quite tight with respect to the dimension of the cavities and would have required a very time-consuming and costly quality check during production, with the constant presence of a CERN staff member at the contractor's and subcontractor's premises. It was therefore decided, in the engineering phase, to foresee a tuning procedure before the final weldings to allow the same final result (precision on fundamental mode frequ...

  5. Investigation of superconducting niobium 1170 MHz cavities

    International Nuclear Information System (INIS)

    Anashin, V.V.; Bibko, S.I.; Fadeyev, E.I.

    1988-01-01

    The design, fabrication and experiments with superconducting L-band single cell cavities are described. These cavities model a cell of an accelerating RF structure. The cavities have been fabricated from technical grade and higher purity grade sheet niobium using deep-drawing, electron beam welding and chemical polishing. They have spherical geometry and are excited in the TM 010 mode. A computerized set-up was used for cavity tests. Qo=1.5 x 10 9 and E acc = 4.3 MV/m were obtained in the cavity made of higher purity grade niobium. 6 references, 8 figures, 3 tables

  6. Prototype 350 MHz niobium spoke-loaded cavities

    International Nuclear Information System (INIS)

    Delayen, J. R.; Kedzie, M.; Mammosser, J.; Piller, C.; Shepard, K. W.

    1999-01-01

    This paper reports the development of 350 MHz superconducting cavities of a spoke-loaded geometry, intended for the velocity range 0.2 < v/c < 0.6. Two prototype single-cell cavities have been designed, one optimized for velocity v/c = 0.4, and the other for v/c = 0.29. Construction of the prototype niobium cavities is nearly complete. Details of the design and construction are discussed, along with the results of cold tests

  7. Prototype 350 MHz niobium spoke-loaded cavities.

    Energy Technology Data Exchange (ETDEWEB)

    Delayen, J. R.; Kedzie, M.; Mammosser, J.; Piller, C.; Shepard, K. W.

    1999-05-10

    This paper reports the development of 350 MHz superconducting cavities of a spoke-loaded geometry, intended for the velocity range 0.2 < v/c < 0.6. Two prototype single-cell cavities have been designed, one optimized for velocity v/c = 0.4, and the other for v/c = 0.29. Construction of the prototype niobium cavities is nearly complete. Details of the design and construction are discussed, along with the results of cold tests.

  8. Design of 118 MHz twelfth harmonic cavity of APS PAR

    International Nuclear Information System (INIS)

    Kang, Y.W.; Kustom, R.L.; Bridges, J.F.

    1992-01-01

    Two radio frequency (RF) cavities are needed in the Positron Accumulator Ring (PAR) of the Advanced Photon Source. One is for the first harmonic frequency at 9.8 MHz, and the other is for the twelfth harmonic frequency at 118 MHz. This note reports on the design of the 118 MHz RF cavity. Computer models are used to find the mode frequencies, impedances, Q-factors, and field distributions in the cavity. The computer codes MAFIA, URMEL, and URMEL-T are useful tools which model and simulate the resonance characteristics of a cavity. These codes employ the finite difference method to solve Maxwell's equations. MAFIA is a three-dimensional problem solver and uses square patches to approximate the inner surface of a cavity. URMEL and URMEL-T are two-dimensional problem solvers and use rectangular and triangular meshes, respectively. URMEL-T and MAFIA can handle problems with arbitrary dielectric materials located inside the boundary. The cavity employs a circularly cylindrical ceramic window to limit the vacuum to the beam pipe. The ceramic window used in the modeling will have a wall thickness of 0.9 cm. This wall thickness is not negligible in determining the resonant frequencies of the cavity. In the following, results of two- and three-dimensional modeling of the cavities using the URMEL-T and MAFIA codes are reported

  9. Early 500 MHz prototype LEP RF Cavity with superposed storage cavity

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    The principle of transferring the RF power back and forth between the accelerating cavity and a side-coupled storage cavity was demonstrated with this 500 MHz prototype. In LEP, the accelerating frequency was 352.2 MHz, and accelerating and storage cavities were consequently larger. See also 8002294, 8006061, 8407619X, and Annual Reports 1980, p.115; 1981, p.95; 1985, vol.I, p.13.

  10. Q0 Degradation of LANL 700-MHZ β = 0.64 Elliptical Cavities and ANL 340 MHZ Spoke Cavities

    International Nuclear Information System (INIS)

    Tajima, Tsuyoshi; Chan, Kwok-Chi D.; Edwards, Randall L.; Gentzlinger, Robert C.; Kelley, John Patrick; Krawczyk, Frank L.; Madrid, Michael A.; Montoya, Debbie I.; Schrage, Dale L.; Shapiro, Alan H.

    2002-01-01

    The quality factor (Q 0 ) of most of the six LANL β = 0.64 700-MHz 5-cell elliptical cavities starts to drop at E acc = 8-10 MV/m, which may be related to multipacting. Residual resistances of these cavities were measured to be 5.0-7.6 n(Omega). The sensitivity of surface resistance to the external magnetic field was measured to be 0.22 n(Omega)/mG. Q disease tests have shown no significant Q 0 degradation for both elliptical cavities and a spoke cavity with our 100 (micro)m BCP.

  11. Characterization of the SPS 800MHz travelling wave cavities.

    CERN Document Server

    Bazyl, Dmitry

    2015-01-01

    It is well known that HOMs in RF cavities are a potentially dangerous source of beam impedance. Therefore, HOMs (both longitudinal and transverse) can drive the beam unstable . The 800MHz cavities of the SPS were studied in the past. However, very little documentation was left behind. Currently, the performance of the SPS is limited by a longitudinal beam instability. In order to study this instability, an accurate impedance model of the whole SPS is needed.

  12. An Automated 476 MHz RF Cavity Processing Facility at SLAC

    CERN Document Server

    McIntosh, P; Schwarz, H

    2003-01-01

    The 476 MHz accelerating cavities currently used at SLAC are those installed on the PEP-II B-Factory collider accelerator. They are designed to operate at a maximum accelerating voltage of 1 MV and are routinely utilized on PEP-II at voltages up to 750 kV. During the summer of 2003, SPEAR3 will undergo a substantial upgrade, part of which will be to replace the existing 358.54 MHz RF system with essentially a PEP-II high energy ring (HER) RF station operating at 476.3 MHz and 3.2 MV (or 800 kV/cavity). Prior to installation, cavity RF processing is required to prepare them for use. A dedicated high power test facility is employed at SLAC to provide the capability of conditioning each cavity up to the required accelerating voltage. An automated LabVIEW based interface controls and monitors various cavity and test stand parameters, increasing the RF fields accordingly such that stable operation is finally achieved. This paper describes the high power RF cavity processing facility, highlighting the features of t...

  13. 201 MHz Cavity R and D for MUCOOL and MICE

    International Nuclear Information System (INIS)

    Li, Derun; Virostek, Steve; Zisman, Michael; Norem, Jim; Bross, Alan; Moretti, Alfred; Norris, Barry; Torun, Yagmur; Phillips, Larry; Rimmer, Robert; Stirbet, Mircea; Reep, Michael; Summers, Don

    2006-01-01

    We describe the design, fabrication, analysis and preliminary testing of the prototype 201 MHz copper cavity for a muon ionization cooling channel. Cavity applications include the Muon Ionization Cooling Experiment (MICE) as well as cooling channels for a neutrino factory or a muon collider. This cavity was developed by the US muon cooling (MUCOOL) collaboration and is being tested in the MUCOOL Test Area (MTA) at Fermilab. To achieve a high accelerating gradient, the cavity beam irises are terminated by a pair of curved, thin beryllium windows. Several fabrication methods developed for the cavity and windows are novel and offer significant cost savings as compared to conventional construction methods. The cavity's thermal and structural performances are simulated with an FEA model. Preliminary high power RF commissioning results will be presented

  14. The 938 MHz resonant damping loops for the 200 MHz SPS travelling wave cavities

    CERN Document Server

    Caspers, F

    2012-01-01

    Measurements of the beam stability in the SPS in 1982 - 1983 have shown a transversal instability for high intensity beams [1]. The fact that this related technical note is published nearly 30 years later, is related to the revival of interest in the frame of SPS impedance evaluation for LS1. Until now there was just a barely known paper folder available which could be consulted on request. The instability mentioned above was identified from beam measurements as raised by a deflecting mode at approximately 940 MHz in the 200 MHz travelling wave cavities of the SPS. Estimates showed that an attenuation of this particular mode by 20 dB would be desirable. In order to achieve this attenuation some vacuum ports on top of the cavities were available. For the damping devices three requirements had to be met: - sufficient damping at about 940 MHz - no serious change of cavity input VSWR at 200 MHz - no water cooling requirement for this higher order mode coupler.

  15. A High Current Proton Linac with 352 MHz SC Cavities

    CERN Document Server

    Pagani, C; Pierini, P

    1996-01-01

    A proposal for a 10-120 mA proton linac employing superconducting beta-graded, CERN type, four cell cavities at 352 MHz is presented. The high energy part (100 MeV-1 GeV) of the machine is split in three beta-graded sections, and transverse focusing is provided via a periodic doublet array. All the parameters, like power in the couplers and accelerating fields in the cavities, are within the state of the art, achieved in operating machines. A first stage of operation at 30 mA beam current is proposed, while the upgrade of the machine to 120 mA operation can be obtained increasing the number of klystrons and couplers per cavity. The additional coupler ports, up to four, will be integrated in the cavity design. Preliminary calculations indicate that beam transport is feasible, given the wide aperture of the 352 MHz structures. A capital cost of less than 100 M$ at 10 mA, reaching up to 280 M$ for the 120 mA extension, has been estimated for the superconducting high energy section (100 MeV-1 GeV). The high effic...

  16. Acne

    Science.gov (United States)

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  17. Design of large aperture 500 MHz 5-cell superconducting cavity

    International Nuclear Information System (INIS)

    Wei Yelong; Feng Ziqiang; Lu Changwang; Yu Haibo; Liu Jianfei; Hou Hongtao; Ma Zhenyu; Mao Dongqing

    2012-01-01

    With the potential application of Energy Recovery Linac (ERL), the superconducting (SC) cavities were developed to deliver much higher current than before. Nowadays, the current of the international SC accelerator designed has already exceeded 100 mA. This paper presents the design of a new 500 MHz 5-cell SC cavity (SINAP 5-cell cavity), in which the parameters r/Q= 515.5 Ω of the fundamental mode and the geometry factor G=275.8 are under an acceptable Radio Frequency (RF) field level. (B peak /E acc =4.31 mT/MV/m and E peak /E acc =2.48). This design employs a larger beam pipe to propagate the Higher Order Modes (HOMs) out of the cavity and increases the damping efficiently for the dangerous HOMs. By simulation technique, it has been found that almost all the dangerous HOMs (including TE 111 , TM 110 , and TM 011 ) can be propagated into the beam pipe and are absorbed by ferrite absorbers, when the beam pile is enlarged. Finally, the loss factor for the new 5-cell cavity is also calculated. (authors)

  18. Acne

    Science.gov (United States)

    ... squeezing existing pimples. Scrubbing your skin too harshly. Chocolate, dirt, and sexual activity do not cause acne. ... of Sun ExposureIt is important to know the benefits and dangers of sun exposure.How to Protect ...

  19. Cavity Processing and Preparation of 650 MHz Elliptical Cell Cavities for PIP-II

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, Allan [Fermilab; Chandrasekaran, Saravan Kumar [Fermilab; Grassellino, Anna [Fermilab; Melnychuk, Oleksandr [Fermilab; Merio, Margherita [Fermilab; Reid, Thomas [Argonne (main); Sergatskov, Dmitri [Fermilab

    2017-05-01

    The PIP-II project at Fermilab requires fifteen 650 MHz SRF cryomodules as part of the 800 MeV LINAC that will provide a high intensity proton beam to the Fermilab neutrino program. A total of fifty-seven high-performance SRF cavities will populate the cryomodules and will operate in both pulsed and continuous wave modes. These cavities will be processed and prepared for performance testing utilizing adapted cavity processing infrastructure already in place at Fermilab and Argonne. The processing recipes implemented for these structures will incorporate state-of-the art processing and cleaning techniques developed for 1.3 GHz SRF cavities for the ILC, XFEL, and LCLS-II projects. This paper describes the details of the processing recipes and associated chemistry, heat treatment, and cleanroom processes at the Fermilab and Argonne cavity processing facilities. This paper also presents single and multi-cell cavity test results with quality factors above 5·10¹⁰ and accelerating gradients above 30 MV/m.

  20. The Phase Servo Tuner Control system of the ALS 500 MHz cavity

    International Nuclear Information System (INIS)

    Lo, C.C.; Taylor, B.

    1993-05-01

    Three 500 MHz cavities are used in the Booster and Storage Ring of the Advanced Light Source (ALS). Due to different varying parameters, a control system is required to keep the cavities in tune during operation. The tuning of the 500 MHz cavity is achieved by detecting the phase error between the drive signal and the cavity probe signal. The error signal is amplified and used to drive a stepping motor which in turn moves a metallic cylinder in or out of the cavity to achieve tuning

  1. Development of 650 MHz (β=0.9) single-cell SCRF cavity

    International Nuclear Information System (INIS)

    Bagre, M.; Jain, V.; Yedle, A.; Maurya, T.; Yadav, A.; Puntambekar, A.; Goswami, S.G.; Choudhary, R.S.; Sandha, S.; Dwivedi, J.; Kane, G.V.; Mahawar, A.; Mohania, P.; Shrivastava, P.; Sharma, S.; Gupta, R.; Sharma, S.D.; Joshi, S.C.; Mistri, K.K.; Prakash, P.N.

    2013-01-01

    Raja Ramanna Centre for Advanced Technology has initiated the work on development of Superconducting Radio Frequency (SCRF) cavities and associated technologies as part of R and D activities for upcoming Spallation Neutron Source (SNS) project involving superconducting Linear Accelerator (LINAC). It is planned to use 650 MHz SCRF cavities for the medium and high energy section of the proposed LINAC. Under Indian Institution Fermilab Collaboration (IIFC), Raja Ramanna Centre for Advanced Technology is also working on development of 650 MHz (β=0.9) SCRF cavities proposed to be used in the high energy section of Project-X at FNAL. The work has been initiated with design and development of 650 MHz single cell SCRF cavity. FE analysis was done to estimate change in frequency with temperature as well as to estimate the frequency of the cavity at different cavity manufacturing stages. The development cycle comprises of design and manufacturing of forming tooling, machining, welding and RF measurement fixtures as well as design for manufacturing. The half-cell and beam tubes forming and machining of all parts were done using in-house facilities. The Electron beam welding was carried out at Inter-University Accelerator Centre (IUAC), New Delhi under a MoU. One 650 MHz single cell SCRF cavity has been recently manufactured. In this paper we present the development efforts on manufacturing and pre-qualification of 650 MHz (β=0.9) single cell SCRF cavity. (author)

  2. A 201-MHz Normal Conducting RF Cavity for the International MICE Experiment

    International Nuclear Information System (INIS)

    Li, D.; DeMello, A.J.; Virostek, Steve; Zisman, Michael S.; Rimmer, Robert

    2008-01-01

    MICE is a demonstration experiment for the ionization cooling of muon beams. Eight RF cavities are proposed to be used in the MICE cooling channel. These cavities will be operated in a strong magnetic field; therefore, they must be normal conducting. The cavity design and construction are based on the successful experience and techniques developed for a 201-MHz prototype cavity for the US MUCOOL program. Taking advantage of a muon beamΛ s penetration property, the cavity employs a pair of curved thin beryllium windows to terminate conventional beam irises and achieve higher cavity shunt impedance. The cavity resembles a round, closed pillbox cavity. Two half-shells spun from copper sheets are joined by e-beam welding to form the cavity body. There are four ports on the cavity equator for RF couplers, vacuum pumping and field probes. The ports are formed by means of an extruding technique.

  3. Compact 400-Mhz Half-Wave Spoke Resonator Crab Cavity for the LHC Update

    International Nuclear Information System (INIS)

    Li, Zenghai

    2010-01-01

    Crab cavities are proposed for the LHC upgrade to improve the luminosity. There are two possible crab cavity installations for the LHC upgrade: the global scheme at Interaction Region (IR) 4 where the beam-beam separation is about 420-mm, and the local scheme at the IR5 where the beam-beam separation is only 194-mm. One of the design requirements as the result of a recent LHC-Crab cavity workshop is to develop a 400-MHz cavity design that can be utilized for either the global or local schemes at IR4 or IR5. Such a design would offer more flexibility for the final upgrade installation, as the final crabbing scheme is yet to be determined, and save R and D cost. The cavity size of such a design, however, is limited by the beam-beam separation at IR5 which can only accommodate a cavity with a horizontal size of about 145-mm, which is a design challenge for a 400-MHz cavity. To meet the new design requirements, we have developed a compact 400-MHz half-wave spoke resonator (HWSR) crab cavity that can fit into the tight spaces available at either IR4 or IR5. In this paper, we present the optimization of the HWSR cavity shape and the design of HOM, LOM, and SOM couplers for wakefield damping.

  4. Progress on the high-current 704 MHz superconducting RF cavity at BNL

    International Nuclear Information System (INIS)

    Xu, W.; Astefanous, C.; Belomestnykh, S.; Ben-Zvi, I.

    2012-01-01

    The 704 MHz high current superconducting cavity has been designed with consideration of both performance of fundamental mode and damping of higher order modes. A copper prototype cavity was fabricated by AES and delivered to BNL. RF measurements were carried out on this prototype cavity, including fundamental pass-band and HOM spectrum measurements, HOM studies using bead-pull setup, prototyping of antenna-type HOM couplers. The measurements show that the cavity has very good damping for the higher-order modes, which was one of the main goals for the high current cavity design. 3D cavity models were simulated with Omega3P code developed by SLAC to compare with the measurements. The paper describes the cavity design, RF measurement setups and results for the copper prototype. The progress with the niobium cavity fabrication will also be described.

  5. Coupler Development and Gap Field Analysis for the 352 MHz Superconducting CH-Cavity

    CERN Document Server

    Liebermann, H; Ratzinger, U; Sauer, A C

    2004-01-01

    The cross-bar H-type (CH) cavity is a multi-gap drift tube structure based on the H-210 mode currently under development at IAP Frankfurt and in collaboration with GSI. Numerical simulations and rf model measurements showed that the CH-type cavity is an excellent candidate to realize s.c. multi-cell structures ranging from the RFQ exit energy up to the injection energy into elliptical multi-cell cavities. The reasonable frequency range is from about 150 MHz up to 800 MHz. A 19-cell, β=0.1, 352 MHz, bulk niobium prototype cavity is under development at the ACCEL-Company, Bergisch-Gladbach. This paper will present detailed MicroWave Studio simulations and measurements for the coupler development of the 352 MHz superconducting CH cavity. It will describe possibilities for coupling into the superconducting CH-Cavity. The development of the coupler is supported by measurement on a room temperature CH-copper model. We will present the first results of the measurements of different couplers, e.g. capacitiv...

  6. Operation of a 473 MHz four-rod cavity RFQ

    International Nuclear Information System (INIS)

    Kazimi, R.; Huson, F.R.; Mackay, W.W.; Meitzler, C.R.

    1992-01-01

    We have constructed a new type of four-rod Radio Frequency Quadrupole to operate at 473 MHz. Four-rod structures have not previously been built for such a high frequency. The RFQ is designed to accelerate 10 mA of H - ions from 30 keV to 0.5 MeV. The rf measurements and beam test of the RFQ have been performed successfully. Here we present operational results of the RFQ system including measurements of the beam current, the required rf power, energy, energy spread, and emittance. (Author) 8 refs., 6 figs., 2 tabs

  7. Fabrication of the prototype 201.25 MHZ cavity for a muon ionization cooling experiment

    International Nuclear Information System (INIS)

    Rimmer, R.A.; Manning, S.; Manus, R.; Phillips, L.; Stirbet, M.; Worland, K.; Wu, G.; Li, D.; MacGill, R.; Staples, J.; Virostek, S.; Zisman, M.S.; Taminger, K.; Hafley, R.; Martin, R.; Summers, D.; Reep, M.

    2005-01-01

    We describe the fabrication and assembly of the first prototype 201. 25 MHz copper cavity for the muon ionization cooling experiment (MICE). This cavity was developed by the US MUCOOL collaboration and will be tested in the new MUCOOL Test Area at Fermilab. We outline the component and subassembly fabrication steps and the various metal forming and joining methods used to produce the final cavity shape. These include spinning, brazing, TIG welding, electron beam welding, electron beam annealing and deep drawing. Some of the methods developed for this cavity are novel and offer significant cost savings over conventional methods

  8. Development of superconducting RF cavity at 1050 MHz frequency for an electron LINAC

    International Nuclear Information System (INIS)

    Sarkar, S.G.; Mondal, J.; Mittal, K.C.

    2011-01-01

    This paper reports the design of a prototype superconducting cavity at 1050 MHz and design of associated die punch and machining fixtures for the cavity fabrication. The cavity is of β= 1 and elliptical in shape. The circle-straight line-ellipse-type structure design has been optimized by 'SUPERFISH' - a 2 dimensional code for cavity tuning. The 3 Dimensional EM field analysis of the cavity structure has been done using 'CST' software. The ratio of the maximum surface electric field to the accelerating gradient, E pk /E acc , is optimised to 1.984 and H pk /E acc is optimised to 4.141 mT/(MV/m). Bore radius of the cavity has been chosen such a way so that the cell-to-cell coupling remains as high as 1.85%. The cavity is designed to achieve 25 MV/m accelerating gradient. (author)

  9. Test results for a heat-treated 4-cell 805 MHz superconducting cavity

    International Nuclear Information System (INIS)

    Rusnak, B.; Shapiro, A.H.

    1995-01-01

    Assessing superconducting technology for potential upgrades to existing proton accelerators as well as applications to future high-current machines necessitates developing expertise in the processing and handling of multicell cavities at useful frequencies. In order to address some of these technological issues, Los Alamos has purchased a 4-cell 805-MHz superconducting cavity from Siemens AG. The individual cavity cells were double-sided titanium heat-treated after equatorial welding, then the irises were welded to complete the cavity assembly. The resulting high RRR (residual resistance ratio) in the cells enables stable operation at higher cavity field levels than are possible with lower RRR material. Additionally, the high thermal conductivity of the material is conducive to rf and high peak power processing. The cavity was also cleaned at Los Alamos with high-pressure water rinsing. Results from the initial cavity tests, utilizing various processing techniques, are presented

  10. Measurement of electrodynamics characteristics of higher order modes for harmonic cavity at 2400 MHz

    Science.gov (United States)

    Shashkov, Ya V.; Sobenin, N. P.; Gusarova, M. A.; Lalayan, M. V.; Bazyl, D. S.; Donetskiy, R. V.; Orlov, A. I.; Zobov, M. M.; Zavadtsev, A. A.

    2016-09-01

    In the frameworks of the High Luminosity Large Hadron Collider (HL-LHC) upgrade program an application of additional superconducting harmonic cavities operating at 800 MHz is currently under discussion. As a possible candidate, an assembly of two cavities with grooved beam pipes connected by a drift tube and housed in a common cryomodule, was proposed. In this article we discuss measurements of loaded Q-factors of higher order modes (HOM) performed on a scaled aluminium single cell cavity prototype with the fundamental frequency of 2400 MHz and on an array of two such cavities connected by a narrow beam pipe. The measurements were performed for the system with and without the matching load in the drift tube..

  11. Computer-aided studies of the ALS 500 MHz storage ring cavity

    International Nuclear Information System (INIS)

    Lo, C.C.; Taylor, B.

    1989-03-01

    The design of the ALS storage ring 500 MHz cavity has been modeled with Mafia and Urmel codes. The effects of the holes cut for the drive port, the higher order mode damping port, the probe port and tuner plunger were modeled with the Mafia codes. The frequency dependence on the shape and spacing of the nose cones and the general shape of the cavity were modeled with Urmel codes. 9 refs., 7 figs., 1 tab

  12. Commissioning of the 112 MHz SRF Gun and 500 MHz bunching cavities for the CeC PoP Linac

    Energy Technology Data Exchange (ETDEWEB)

    Belomestnykh, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stony Brook Univ., NY (United States); Ben-Zvi, I. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stony Brook Univ., NY (United States); Brutus, J. C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Litvinenko, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stony Brook Univ., NY (United States); McIntosh, P. [Science and Technology Facilities Council (STFC), Daresbury (United Kingdom). Daresbury Lab.; Moss, A. [Science and Technology Facilities Council (STFC), Daresbury (United Kingdom). Daresbury Lab.; Narayan, G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Orfin, P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pinayev, I. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rao, T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Skaritka, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Smith, K. [Brookhaven National Lab. (BNL), Upton, NY (United States); Than, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tuozzolo, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wang, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wheelhouse, A. [Science and Technology Facilities Council (STFC), Daresbury (United Kingdom). Daresbury Lab.; Wu, Q. [Brookhaven National Lab. (BNL), Upton, NY (United States); Xiao, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Xin, T. [Stony Brook Univ., NY (United States); Xu, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Zaltsman, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    The Coherent electron Cooling Proof-of-Principle (CeC PoP) experiment at BNL includes a short electron linac. During Phase 1, a 112 MHz superconducting RF photo-emission gun and two 500 MHz normal conducting bunching cavities were installed and are under commissioning. The paper describes the Phase1 linac layout and presents commissioning results for the cavities and associated RF, cryogenic and other sub-systems

  13. Measurements on the SPS 200 MHz Travelling Wave Cavity towards an Impedance Model

    CERN Document Server

    Roggen, Toon; Caspers, Fritz; Vollinger, Christine; CERN. Geneva. ATS Department

    2016-01-01

    This note discusses the contribution of the SPS 200 MHz TWC (Travelling Wave Cavity) to the SPS longitudinal impedance model. The measurement method and setup is briefly explained and a comparison with simulations is discussed for both the fundamental pass band (FPB) as well as the Higher Order Modes (HOMs). In addition a number of improvements to the measurement setup are discussed.

  14. Buffer Chemical Polishing and RF Testing of the 56 MHz SRF Cavity

    Energy Technology Data Exchange (ETDEWEB)

    Burrill,A.

    2009-01-01

    The 56 MHz cavity presents a unique challenge in preparing it for RF testing prior to construction of the cryomodule. This challenge arises due to the physical dimensions and subsequent weight of the cavity, and is further complicated by the coaxial geometry, and the need to properly chemically etch and high pressure rinse the entire inner surface prior to RF testing. To the best of my knowledge, this is the largest all niobium SRF cavity to be chemically etched and subsequently tested in a vertical dewar at 4K, and these processes will be the topic of this technical note.

  15. Mechanical analysis of a $\\beta=0.09 $ 162.5MHz taper HWR cavity

    OpenAIRE

    Fan, Peiliang; Zhu, Feng; Zhong, Hutianxiang; Quan, Shengwen; Liu, Kexin

    2015-01-01

    One superconducting taper-type half-wave resonator (HWR) with frequency of 162.5MHz, \\b{eta} of 0.09 has been developed at Peking University, which is used to accelerate high current proton ($\\sim$ 100mA) and $D^{+}$($\\sim$ 50mA). The radio frequency (RF) design of the cavity has been accomplished. Herein, we present the mechanical analysis of the cavity which is also an important aspect in superconducting cavity design. The frequency shift caused by bath helium pressure and Lorenz force, and...

  16. Design and analysis of magnetic shield for 650 MHz SCRF cavity

    International Nuclear Information System (INIS)

    Thakur, Vanshree; Jain, Vikas; Das, S.; Shinde, R.S.; Joshi, S.C.

    2015-01-01

    Five-cell, 650 MHz Superconducting RF (SCRF) cavity is being developed at RRCAT for the Injector Linac of proposed ISNS project. The SCRF cavity needs to be shielded effectively from earth magnetic field. The external magnetic field can cause magnetic field trapping that limits the performance of SCRF cavity. The allowable limit of earth magnetic field in the cavity surface is < 10 mG. The magnetic shielding analysis carried out for 650 MHz dressed SCRF cavity is presented in this paper. For axial magnetic field shielding analysis, 2-D code PANDIRA has been used. A 2-D axisymmetric geometry (cylinder of Cryoperm10 sheet with 460 mm diameter of various thickness and 1100 mm length) has been modelled and analyzed in the presence of 240 mG external axial magnetic field. The influence of partial opening of 120 mm diameter at both ends of the cylinder on magnetic field pattern inside the shielded region has been evaluated. The transverse magnetic shielding analysis in the presence of 500 mG transverse external field has been carried out using OPERA 3D code. The flux leakage through the major openings for cavity supports, ports on the shield is investigated and accordingly the openings are designed to minimize the leakage. Inference of material thickness on the magnetic shielding for reducing magnetic field below specified limit has been investigated. Details of design and analysis of magnetic shield for SCRF cavity will be discussed in this paper. (author)

  17. Comparison of higher order modes damping techniques for 800 MHz single cell superconducting cavities

    Science.gov (United States)

    Shashkov, Ya. V.; Sobenin, N. P.; Petrushina, I. I.; Zobov, M. M.

    2014-12-01

    At present, applications of 800 MHz harmonic cavities in both bunch lengthening and shortening regimes are under consideration and discussion in the framework of the High Luminosity LHC project. In this paper we study electromagnetic characteristics of high order modes (HOMs) for a single cell 800 MHz superconducting cavity and arrays of such cavities connected by drifts tubes. Different techniques for the HOMs damping such as beam pipe grooves, coaxial-notch loads, fluted beam pipes etc. are investigated and compared. The influence of the sizes and geometry of the drift tubes on the HOMs damping is analyzed. The problems of a multipacting discharge in the considered structures are discussed and the operating frequency detuning due to the Lorentz force is evaluated.

  18. Development of 400- to 450-MHz RFQ resonator-cavity mechanical designs

    International Nuclear Information System (INIS)

    Hansborough, L.D.

    1982-01-01

    In the development of the radio-frequency quadrupole (RFQ) linac, the resonator cavity's mechanical design may be a challenge similar in magnitude to that of the development of the accelerator structure itself. Experience with the all-copper 425-MHz RFQ proof-of-principle linac has demonstrated that the resonator cavity must be structurally stiff and easily tunable. This experience has led to development of copper-plated steel structures having vanes that may be moved within a cylinder for tuning. Design of a flexible vane-to-cylinder radio-frequency (rf) joint, the vane, and the cylinder has many constraints dictated by the small-diameter cavities in the 400-MHz-frequency region. Two types of flexible, mechanical vane-to-cylinder rf joints are being developed at Los Alamos: the C-seal and the rf clamp-joint

  19. Comparison of higher order modes damping techniques for 800 MHz single cell superconducting cavities

    Energy Technology Data Exchange (ETDEWEB)

    Shashkov, Ya.V., E-mail: shashkovyv@mail.ru [National Research Nuclear University MEPhI, Moscow (Russian Federation); Sobenin, N.P.; Petrushina, I.I. [National Research Nuclear University MEPhI, Moscow (Russian Federation); Zobov, M.M. [Laboratori Nazionali di Frascati INFN, Rome (Italy)

    2014-12-11

    At present, applications of 800 MHz harmonic cavities in both bunch lengthening and shortening regimes are under consideration and discussion in the framework of the High Luminosity LHC project. In this paper we study electromagnetic characteristics of high order modes (HOMs) for a single cell 800 MHz superconducting cavity and arrays of such cavities connected by drifts tubes. Different techniques for the HOMs damping such as beam pipe grooves, coaxial-notch loads, fluted beam pipes etc. are investigated and compared. The influence of the sizes and geometry of the drift tubes on the HOMs damping is analyzed. The problems of a multipacting discharge in the considered structures are discussed and the operating frequency detuning due to the Lorentz force is evaluated.

  20. Simulation of the High-Pass Filter for 56MHz Cavity for RHIC

    International Nuclear Information System (INIS)

    Wu, Q.; Ben-Zvi, I.

    2010-01-01

    The 56MHz Superconducting RF (SRF) cavity for RHIC places high demands High Order Mode (HOM) damping, as well as requiring a high field at gap with fundamental mode frequency. The damper of 56MHz cavity is designed to extract all modes to the resistance load outside, including the fundamental mode. Therefore, the circuit must incorporate a high-pass filter to reflect back the fundamental mode into the cavity. In this paper, we show the good frequency response map obtained from our filter's design. We extract a circuit diagram from the microwave elements that simulate well the frequency spectrum of the finalized filter. We also demonstrate that the power dissipation on the filter over its frequency range is small enough for cryogenic cooling.

  1. Electromagnetic design of a β=0.9, 650 MHz elliptic superconducting radio frequency cavity

    International Nuclear Information System (INIS)

    Jana, Arup Ratan; Kumar, V.

    2011-01-01

    We have recently performed two-dimensional (2D) electromagnetic design studies of a β=0.9, 650 MHz, elliptic superconducting radio frequency (SCRF) cavity using electromagnetic field solver code SUPERFISH. We have evolved the design starting from the design parameters of β=1, 1300 MHz, TESLA design SCRF cavity and then scaled it for the β=0.9 and 650 MHz case. The design has been optimized for minimizing the SCRF cavity power loss. One of the important parameters in the design of such elliptic SCRF cavities is the wall angle, which is defined as the vertical angle made by the common tangent to the iris and equator ellipses. Generally, there is a constraint on the minimum value of the wall angle, which is decided by the mechanical considerations, ease of chemical cleaning etc. In our optimization studies, we have first explored the case when there is no such constraint on wall angle. We find that from the point of view of low cavity power dissipation, the optimized design has a re-entrant geometry, where the wall angle is negative. We then perform design optimization, keeping the constraint that the wall angle should be greater than 5 degree. Keeping this constraint, we find that our optimized design parameters for the single cell match closely with the design parameters reported for Project-X. We discuss the results of 2D electromagnetic field calculations for this design using SUPERFISH. In the next, we have performed the design studies of the multi-cell β=0.9, 650 MHz, elliptic SCRF cavity. The design parameters of end-cells are optimized such that the frequency of the end-cell is matched to that of mid-cells. We have studied all the normal modes for the multi-cell cavity. The frequency of different normal modes is also calculated using a finite element code ANSYS and results are compared with those obtained using SUPERFISH. The field flatness, which is an important design criterion, is also studied. For multi-cell cavity, another important aspect is the cell

  2. Fundamental damper power calculation of the 56 MHz SRF cavity for RHIC

    International Nuclear Information System (INIS)

    Wu, Q.; Bellavia, S.; Ben-Zvi, I.; Grau, M.; Miglionico, G.; Pai, C.

    2011-01-01

    At each injection period during RHIC's operation, the beam's frequency sweeps across a wide range, and some of its harmonics will cross the frequency of the 56MHz SRF cavity. To avoid excitation of the cavity at these times, we designed a fundamental damper for the quarter-wave resonator to damp the cavity heavily. The power extracted by the fundamental damper should correspond to the power handling ability of the system at all stages. In this paper, we discuss the power output from the fundamental damper when it is fully extracted, inserted, and any intermediate point. A Fundamental Damper (FD) will greatly reduce the cavity's Q factor to ∼300 during the acceleration phase of the beam. However, when the beam is at store and the FD is removed, the cavity is excited by both the yellow and the blue beams at 2 x 0.3A to attain the required 2MV voltage across its gap. The cavity then is operated to increase the luminosity of the RHIC experiments. Table 1 lists the parameters of the FD. Figure 1 shows the configuration of the FD fully inserted into the 56MHz SRF cavity; this complete insertion is defined as the start location (0cm) of FD simulation, an assumption we make throughout this paper. The power consumed by the cavity while maintaining the beam's energy and its orbit is compensated by the 28MHz accelerating cavities in the storage ring. The power dissipation of the external load is dynamic with respect to the position of the FD during its extraction. As a function of the external Q and the EM field in the cavity, the power should peak with the FD at a certain vertical location. Our calculation of the power extracted is detailed in the following sections. Figure 2 plots the frequency change in the cavity, and the external Q against the changes in position of the FD. The location of the FD is selected carefully such that the frequency will approach the designed working point from the lower side only. The loaded Q of the cavity is 223 when the FD is fully

  3. Status of the mechanical design of the 650 MHz cavities for Project X

    Energy Technology Data Exchange (ETDEWEB)

    Barbanotti, S.; Grimm, C.; Champion, M.; Foley, M.; Ginsburg, C.M.; Gonin, I.; Peterson, T.; Ristori, L.; Yakovlev, V.; /Fermilab

    2011-03-01

    In the high-energy section of the Project X Linac, acceleration of H{sup -} ions takes place in superconducting cavities operating at 650 MHz. Two families of five-cell elliptical cavities are planned: beta = 0.61 and beta = 0.9. A specific feature of the Project X Linac is low beam loading, and thus, low bandwidth and higher sensitivity to microphonics. Efforts to optimize the mechanical design of the cavities to improve their mechanical stability in response to the helium bath pressure fluctuations will be presented. These efforts take into account constraints such as cost and ease of fabrication. Also discussed will be the overall design status of the cavities and their helium jackets. The proposed design of the 3 GeV Project X superconducting (SC) Linac employs 650 MHz five-cell elliptical cavities to accelerate 1.0 mA of average H-beam current in the 160-3000 MeV energy range. The 650 MHz region of the Linac is divided into two sections with two different geometric phase velocity factors: beta = 0.61 to cover the 160-520 MeV range and beta = 0.9 to cover the 520-3000 MeV range. Approximately 40 beta = 0.61 and 150 beta = 0.9 cavities are currently planned for the project. An R&D program is in progress at FNAL, in collaboration with TJNAF and India, to develop the 650 MHz cavities for the proposed Linac design. This R&D program includes the design and fabrication of several beta = 0.61 and beta = 0.9 single-cell prototypes for evaluation prior to production of the five-cell cavities. FNAL has contracted AES to fabricate the beta = 0.9 prototypes, while TJNAF is building beta = 0.61 prototypes of their own design. In the remainder of this paper we will restrict our discussion to the five-cell beta = 0.9 cavities.

  4. High power RF test of an 805 MHz RF cavity for a muon cooling channel

    International Nuclear Information System (INIS)

    Li, Derun; Corlett, J.; MacGill, R.; Rimmer, R.; Wallig, J.; Zisman, M.; Moretti, A.; Qian, Z.; Wu, V.; Summers, D.; Norem, J.

    2002-01-01

    We present recent high power RF test results on an 805 MHz cavity for a muon cooling experiment at Lab G in Fermilab. In order to achieve high accelerating gradient for large transverse emittance muon beams, the cavity design has adopted a pillbox like shape with 16 cm diameter beam iris covered by thin Be windows, which are demountable to allow for RF tests of different windows. The cavity body is made from copper with stiff stainless steel rings brazed to the cavity body for window attachments. View ports and RF probes are available for visual inspections of the surface of windows and cavity and measurement of the field gradient. Maximum of three thermo-couples can be attached to the windows for monitoring the temperature gradient on the windows caused by RF heating. The cavity was measured to have Q 0 of about 15,000 with copper windows and coupling constant of 1.3 before final assembling. A 12 MW peak power klystron is available at Lab G in Fermilab for the high power test. The cavity and coupler designs were performed using the MAFIA code in the frequency and the time domain. Numerical simulation results and cold test measurements on the cavity and coupler will be presented for comparisons

  5. Production and Test of 352 MHZ Niobum-Sputtered Reduced-$\\beta$ Cavities

    CERN Document Server

    Benvenuti, Cristoforo; Calatroni, Sergio; Chiaveri, Enrico; Tückmantel, Joachim

    1997-01-01

    Three types of 352 MHz single-cell cavities foreseen for different particle speeds (v/c=0.8, 0.625 and 0.48) have been designed and built with the niobium sputtered on copper technique. We report on the results of the cold tests at 4.5 and 2.5 K and the actual status of the data analysis.

  6. Optimizing of the higher order mode dampers in the 56MHz SRF cavity

    International Nuclear Information System (INIS)

    Wu, Q.; Ben-Zvi, I.

    2010-01-01

    Earlier, we reported that a 56 MHz cavity was designed for a luminosity upgrade of the RHIC, and presented the requirements for Higher Order Mode (HOM) damping, the design of the HOM dampers, along with measurements and simulations of the HOM dampers. In this report, we describe our optimization of the dampers performance, and the modifications we made to their original design. We also optimized the number of the HOM dampers, and tested different configurations of locations for them.

  7. Design of 650 MHz, β=0.61, 5-cell SRF cavity and development of single cell niobium cavity

    International Nuclear Information System (INIS)

    Seth, Sudeshna; Som, Sumit; Bhattacharyya, Pranab

    2015-01-01

    In India, DAE laboratories and other institutes are now actively involved in research and development activities on SRF cavities and associated technologies for the proposed high current, high energy proton linear accelerators like ISNS/IADS and also for the FERMILAB PIP-II program under Indian institutions-Fermilab collaboration (IIFC). As part of the above activities, VECC, Kolkata, has been involved in the design, analysis and development of a 650 MHz, β=0.61, 5-cell elliptical shape Superconducting RF linac cavity. RF design involves optimization of the geometry to get acceptable values of field enhancement factors (magnetic and electric), R/Q , Geometric factor, coupling factor and field flatness. This paper describes the RF design using 2-D superfish and 3-D CST Microwave studio and multipacting analysis using 2-D Multipac2.1 and 3-D CST Particle Studio. A prototype 1-cell aluminum cavity and a prototype 5-cell copper cavity have been fabricated using die-punch assembly designed for fabrication of elliptical half-cells to check the procedures for forming and to make sure the desired frequency and field flatness could be obtained. RF characterization has been carried out for both the prototypes using Vector Network Analyzer and Bead pull measurement set up.The fabrication of a single-cell niobium cavity has been carried out indigenously and with the help of Electron Beam Welding (EBW) facility at IUAC, New Delhi. CMM measurement and RF characterization of the niobium half cells and full cell cavities have been carried out. This paper describes the development and measurement of prototype cavities and single cell niobium cavity. (author)

  8. Geometric optimization of the 56 MHz SRF cavity and its frequency table

    International Nuclear Information System (INIS)

    Chang, X.; Ben-Zvi, I.

    2008-01-01

    It is essential to know the frequency of a Superconducting Radio Frequency (SRF) cavity at its 'just being fabricated' stage because frequency is the key parameter in constructing the cavity. In this paper, we report our work on assessing it. We can estimate the frequency change from stage to stage theoretically and/or by simulation. At the operating stage, the frequency can be calculated accurately, and, from this value, we obtain the frequencies at other stages. They are listed in a table that serves to check the processes from stage to stage. Equally important is optimizing the geometric shape of the SRF cavity so that the peak electric-field and peak magnetic-field are as low as possible. It is particularly desirable in the 56MHz SRF cavity of RHIC to maximize the frequency sensitivity of the slow tuner. After undertaking such optimization, our resultant peak electric-field is only 44.1MV/m, and the peak magnetic-field is 1049G at 2.5MV of voltage across the cavity gap. To quench superconductivity in an SRF cavity, it is reported that the limit of the peak magnetic-field is 1800G (1), and that of the peak electric-field is more than l00MV/m for a SRF cavity (2). Our simulations employed the codes Superfish and Microwave Studio

  9. Design of horizontal test cryostat for testing two 650 MHz cavities: cryogenic considerations

    Science.gov (United States)

    Khare, P.; Gilankar, S.; Kush, P. K.; Lakshminarayanan, A.; Choubey, R.; Ghosh, R.; Jain, A.; Patel, H.; Gupta, P. D.; Hocker, A.; Ozelis, J. P.; Geynisman, M.; Reid, C.; Poloubotko, V.; Mitchell, D.; Peterson, T. J.; Nicol, T. H.

    2017-02-01

    Horizontal Test Cryostat has been designed for testing two 650 MHz "dressed" Superconducting Radio Frequency (SCRF) cavities in a single testing cycle at Raja Ramanna Centre for Advanced Technology, India (RRCAT) in collaboration with Fermi National Accelerator Laboratory, USA (FNAL). This cryostat will facilitate testing of two 5-cell 650 MHz SCRF cavities, in CW or pulsed regime, for upcoming High Intensity Superconducting Proton Accelerator projects at both countries. Two such HTS facilities are planned, one at RRCAT for Indian Spallation Neutron Source project (ISNS), which is on the horizon, and the other at FNAL, USA. A test cryostat, a part of horizontal test stand-2 (HTS-2) will be set up at RRCAT for Indian project. In order to maximize the utility of this facility, it can also be used to test two dressed 9-cell 1.3 GHz cavities and other similarly-sized devices. The facility assumes, as an input, the availability of liquid nitrogen at 80 K and liquid helium at 4.5 K and 2 K, with a refrigeration capacity of approximately 50 W at 2 K. Design work of cryostat has been completed and now procurement process is in progress. This paper discusses salient features of the cryostat. It also describes different design calculations and ANSYS analysis for cool down of few subsystems like cavity support system and liquid nitrogen cooled thermal radiation shield of horizontal test cryostat..

  10. Development of a cryostat for the 4-cell 352 MHz sc accelerating cavities at LEP

    International Nuclear Information System (INIS)

    Stierlin, R.

    1988-01-01

    The upgrading of LEP by s.c. cavities will require installation and operation of a few hundred 350 MHz, 4-cell cavities in the accelerator tunnel. It is at present anticipated to install eight cavities per rf-cell which have a length of ∼ 24 m. A tunnel slope of up to 1.5% and a tunnel diameter of 4.4 m have to be accommodated. For the design of adequate cryostats the following guiding lines were considered: up to eight cavities with their He tank could be housed in a common insulation vacuum. Cryostats should be modular and allow installation of individual cavities or groups of two cavities (with a total length not exceeding 6 m thus enabling normal transport inside the access pits and machine tunnel). A high accessibility to all critical parts like couplers, tuners and beam tube connections should be guaranteed. This requirement dictates a lateral access through the vacuum tank and thermal radiation shield which should also permit the removal and replacement of any one 4-cell cavity without disturbing the neighboring units. Cavity connections to the beam vacuum system as well as repairs should be possible under reasonably clean and dust-free conditions, particularly when keeping cavities under a slight overpressure of dry, dust-free protective gas. A test program was launched and a 1/5 scale model vacuum tank was constructed and tested. The main feature of this model was a frame and sealing skin design which offers complete accessibility to the inside of the vessel. The results obtained prompted the design and construction of a full size model which was completed in 1985 and proved the feasibility of the new concepts. A thin copper radiation shield mechanically clamped to the piping carrying the refrigerant and thus easily removable to meet the requirement of accessibility also proved adequate to intercept and evacuate the heat radiated by the vacuum tank. 4 references, 6 figures

  11. Mechanical design of 56 MHz superconducting RF cavity for RHIC collider

    Energy Technology Data Exchange (ETDEWEB)

    Pai, C.; Ben-Zvi, I.; Burrill, A.; Chang, X.; McIntyre, G.; Than, Y.; Tuozzolo, J.; Wu, Q.

    2011-03-28

    A 56 MHz Superconducting RF Cavity operating at 4.4K is being constructed for the RHIC collider. This cavity is a quarter wave resonator with beam transmission along the centerline. This cavity will increase collision luminosity by providing a large longitudinal bucket for stored bunches of RHIC ion beam. The major components of this assembly are the niobium cavity with the mechanical tuner, its titanium helium vessel and vacuum cryostat, the support system, and the ports for HOM and fundamental dampers. The cavity and its helium vessel must meet equivalent safety with the ASME pressure vessel code and it must not be sensitive to frequency shift due to pressure fluctuations from the helium supply system. Frequency tuning achieved by a two stage mechanical tuner is required to meet performance parameters. This tuner mechanism pushes and pulls the tuning plate in the gap of niobium cavity. The tuner mechanism has two separate drive systems to provide both coarse and fine tuning capabilities. This paper discusses the design detail and how the design requirements are met.

  12. Development of high pressure rinsing set up for 650 MHz, 5- cell superconducting RF cavity cleaning

    International Nuclear Information System (INIS)

    Suhane, S.K.; Chauhan, S.K.; Bose, A.; Kokil, S.V.; Rajput, D.S.; Oraon, B.; Md Hussain; Sahu, A.; Raghavendra, S.; Joshi, S.C.

    2015-01-01

    High pressure rinsing (HPR) is an ultra-cleanliness process for the surface preparation of high field superconducting RF cavities. Any dust particle or chemical residue on the interior of cavity causes field emission. Jets of high pressure (80-100 bar) ultra pure water dislodge surface contaminants that normally resist removal with conventional rinsing procedures, leading to substantial reduction in field emission and better cavity performance. For cleaning of 650 MHz, 5-cell SRF cavities, a high pressure rinsing set up has been developed at RRCAT. The HPR tool has a rotating wand coaxial with the vertically mounted SRF cavity that is moving up and down. Fan style spray nozzles are attached to the end of the rotating wand and the water jets emerging from spray nozzles scan the entire internal surface of the cavity. The set-up was installed in a specially built clean area meeting cleanliness class 100 standards. The ultrapure water with resistivity 2 ≥ 18 MΩ-cm required for rinsing is obtained from a dedicated water purification system installed for this purpose. The paper describes the salient design and constructional details of the high pressure rinsing set up. Characterization of water jet parameters based on the momentum transfer between the water jet and a load cell is also presented. (author)

  13. Design, fabrication and low power RF testing of a prototype beta=1, 1050 MHz cavity developed for electron linac

    International Nuclear Information System (INIS)

    Sarkar, S.; Mondal, J.; Mittal, K.C.

    2013-01-01

    A single cell 1050 MHz β = 1 elliptical cavity has been designed for possible use in High energy electron accelerator. A prototype Aluminium cavity has been fabricated by die punch method and low power testing of the cavity has been carried out by using VNA. The fundamental mode frequency of the prototype cavity is found out to be 1051.38 MHz and Q (loaded) and Q0 values corresponding to 2 modes are 8439 and 10013 respectively. Cell to cell coupling coefficient is 1.82 % from measurement which matches with the designed value (1.84%). The higher order mode frequencies are also measured and electric field of the cavity is confirmed by bead pull method. Low power RF measurements on the prototype cavity indicate that the critical RF parameters (Qo, f, Kc etc) for the cavity are consistent with the designed value. (author)

  14. RF, Thermal and Structural Analysis of the 201.25 MHz Muon Ionization Cooling Cavity

    International Nuclear Information System (INIS)

    Virostek, S.; Li, D.

    2005-01-01

    A finite element analysis has been carried out to characterize the RF, thermal and structural behavior of the prototype 201.25 MHz cavity for a muon ionization cooling channel. A single ANSYS model has been developed to perform all of the calculations in a multi-step process. The high-gradient closed-cell cavity is currently being fabricated for the MICE (international Muon Ionization Cooling Experiment) and MUCOOL experiments. The 1200 mm diameter cavity is constructed of 6 mm thick copper sheet and incorporates a rounded pillbox-like profile with an open beam iris terminated by 420 mm diameter, 0.38 mm thick curved beryllium foils. Tuning is accomplished through elastic deformation of the cavity, and cooling is provided by external water passages. Details of the analysis methodology will be presented including a description of the ANSYS macro that computes the heat loads from the RF solution and applies them directly to the thermal model. The process and results of a calculation to determine the resulting frequency shift due to thermal and structural distortion of the cavity will also be presented

  15. Fermilab 500 GeV main accelerator rf cavity 128 MHz mode damper

    International Nuclear Information System (INIS)

    Kerns, Q.A.; Miller, H.W.

    1977-01-01

    The Fermilab 500-GeV main accelerating system has been operating for a year now with the aid of 128-MHz mode dampers. Such dampers proved to be necessary to achieve stable operation and a reasonably smooth slow spill at intensities of approximately 2 x 10 13 protons per pulse, and furthermore are low-cost and reliable. The approach used to identify troublesome modes, the observed beam blow-up without dampers, and the steps taken to design and install suitable dampers on eighteen main ring cavities are discussed. Spectrum analyzer pictures help illustrate the performance

  16. An object-oriented implementation of the TRIUMF 92 MHz booster cavity control system

    International Nuclear Information System (INIS)

    Wilkinson, N.A.; Ludgate, G.A.

    1992-01-01

    A 92 MHz auxiliary accelerating cavity has been designed for installation inside the TRIUMF cyclotron, operating up to a maximum peak voltage of 200 kV. The cavity doubles the energy gain per turn for accelerating hydrogen ions in the energy region of 400-500 MeV, and reduces by 50% the stripping loss of the ion beam. The control system for the booster comprises a PC-based processor in a VME crate, for local control, and a 68030 processor with an ethernet connection as the interface to the TRIUMF Central Control System. The requirements for the booster control system were established by an object-oriented requirements analysis. Afterward, an object-oriented architectural design step was used to produce the processor allocation of the design, which was then implemented using C, for the VME processor, and a commercial database and screen generator product, for the VAX user interface. (author)

  17. Niobium thin film coating on a 500-MHz copper cavity by plasma deposition

    Energy Technology Data Exchange (ETDEWEB)

    Haipeng Wang; Genfa Wu; H. Phillips; Robert Rimmer; Anne-Marie Valente; Andy Wu

    2005-05-16

    A system using an Electron Cyclotron Resonance (ECR) plasma source for the deposition of a thin niobium film inside a copper cavity for superconducting accelerator applications has been designed and is being constructed. The system uses a 500-MHz copper cavity as both substrate and vacuum chamber. The ECR plasma will be created to produce direct niobium ion deposition. The central cylindrical grid is DC biased to control the deposition energy. This paper describes the design of several subcomponents including the vacuum chamber, RF supply, biasing grid and magnet coils. Operational parameters are compared between an operating sample deposition system and this system. Engineering work progress toward the first plasma creation will be reported here.

  18. An update on the study of high-gradient elliptical SRF cavities at 805 MHz for proton and other applications

    Energy Technology Data Exchange (ETDEWEB)

    Tajima, Tsuyoshi [Los Alamos National Laboratory; Haynes, Brian [Los Alamos National Laboratory; Krawczyk, Frank [Los Alamos National Laboratory; Madrid, Mike [Los Alamos National Laboratory; Roybal, Ray [Los Alamos National Laboratory; Simakov, Evgenya [Los Alamos National Laboratory; Clemens, Bob [TJNAF; Macha, Jurt [TJNAF; Manus, Bob [TJNAF; Rimmer, Bob [TJNAF; Rimmer, Bob [TJNAF; Turlington, Larry [TJNAF

    2010-09-09

    An update on the study of 805 MHz elliptical SRF cavities that have been optimized for high gradient will be presented. An optimized cell shape, which is still appropriate for easy high pressure water rinsing, has been designed with the ratios of peak magnetic and electric fields to accelerating gradient being 3.75 mT/(MV/m) and 1.82, respectively. A total of 3 single-cell cavities have been fabricated. Two of the 3 cavities have been tested so far. The second cavity achieved an E{sub acc} of {approx}50 MV/m at Q{sub 0} of 1.4 x 10{sup 10}. This result demonstrates that 805 MHz cavities can, in principle, achieve as high as, or could even be better than, 1.3 GHz high-gradient cavities.

  19. Development efforts on helium vessel for 5 cell - 650 MHz SRF cavity at RRCAT

    International Nuclear Information System (INIS)

    Kumar, Abhay; Kumar, Pankaj; Sandha, R.S.; Dutta, Subhajit; Soni, Rakesh; Dwivedi, Jishnu; Thakurta, A.C.; Bhatnagar, V.K.; Mundra, G.

    2011-01-01

    The work focuses on the development of helium vessel which houses a 5 cell - 650 MHz SRF niobium cavity and serves as a helium bath to maintain the cavity at 2 K. The vessel has provision for changing the axial length of the cavity for tuning purpose by using a tuning mechanism and a large bellow. Titanium has been chosen as a material of construction of the vessel due to its coefficient of thermal expansion being close to that of niobium. Efforts have been initiated to understand the functional requirements, design requirements, acceptance criteria for design and analysis, non-destructive examination requirements, inspection and testing requirements, manufacturing technology of the titanium vessel and its integration with the SRF cavity. The welding assumes a special significance as titanium is highly reactive and ductility of the weld joint is lost in the presence of air and other impurities. A trial vessel has been conceptualised having typical sizes and geometries. The manufacturing features of vessel are based on ASME B and PV Code, Section VIII Division-1 and manufacturing of this vessel has been started at an Indian industry. Quality assurance plan for this work is developed. The paper describes the work done at RRCAT on the functional and integration requirements, overall design requirements, design methodology to achieve code conformance, manufacturing technology and QAP being used in the development of helium vessel. (author)

  20. Multiplacting analysis on 650 MHz, BETA 0.61 superconducting RF LINAC cavity

    International Nuclear Information System (INIS)

    Seth, Sudeshna; Som, Sumit; Mandal, Aditya; Ghosh, Surajit; Saha, S.

    2013-01-01

    Design, analysis and development of high-β multi-cell elliptical shape Superconducting RF linac cavity has been taken up by VECC, Kolkata as a part of IIFC collaboration. The project aims to provide the-art technology achieving very high electric field gradient in superconducting linac cavity, which can be used in high energy high current proton linear accelerator to be built for ADSS/SNS programme in India and in Project-X at Fermilab, USA. The performance of this type of superconducting RF structure can be greatly affected due to multipacting when we feed power to the cavity. Multipacting is a phenomenon of resonant electron multiplication in which a large number of electrons build up an electron Avalanche which absorbs RF Energy leading to remarkable power losses and heating of the walls, making it impossible to raise the electric field by increasing the RF Power. Multipacting analysis has been carried out for 650 MHz, β=0.61, superconducting elliptical cavity using 2D code MultiPac 2.1 and 3 D code CST particle studio and the result is presented in this paper. (author)

  1. Effect of high solenoidal magnetic fields on breakdown voltages of high vacuum 805 MHz cavities

    International Nuclear Information System (INIS)

    Moretti, A.; Bross, A.; Geer, S.; Qian, Z.; Norem, J.; Li, D.; Zisman, M.; Torun, Y.; Rimmer, R.; Errede, D.

    2005-01-01

    There is an on going international collaboration studying the feasibility and cost of building a muon collider or neutrino factory [1,2]. An important aspect of this study is the full understanding of ionization cooling of muons by many orders of magnitude for the collider case. An important muon ionization cooling experiment, MICE [3], has been proposed to demonstrate and validate the technology that could be used for cooling. Ionization cooling is accomplished by passing a high-emittance muon beam alternately through regions of low Z material, such as liquid hydrogen, and very high accelerating RF Cavities within a multi-Tesla solenoidal field. To determine the effect of very large solenoidal magnetic fields on the generation of dark current, x-rays and on the breakdown voltage gradients of vacuum RF cavities, a test facility has been established at Fermilab in Lab G. This facility consists of a 12 MW 805 MHz RF station and a large warm bore 5 T solenoidal superconducting magnet containing a pill box type cavity with thin removable window apertures. This system allows dark current and breakdown studies of different window configurations and materials. The results of this study will be presented. The study has shown that the peak achievable accelerating gradient is reduced by a factor greater than 2 when solenoidal field of greater than 2 T are applied to the cavity

  2. Development of an optical inspection bench for the inspection of internal surfaces of 650 MHz SCRF cavities

    International Nuclear Information System (INIS)

    Kokil, S.V.; Kane, G.V.; Raghavendra, S.; Chauhan, S.K.; Rajpoot, D.S.; Oraon, B.; Om Prakash; Joshi, S.C.

    2015-01-01

    An optical inspection system has been developed for inspection of internal surfaces of 650 MHz superconducting RF cavities. The cavity parts are welded either using Electron Beam or Laser Beam Welding for making a good quality of weld joints. Surface defects like pits, scratches, welding spatters etc. on the internal surface of the cavity deteriorates cavity performance. Surface quality of the cavity equator joint plays an important role in the cavity performance. To study the quality of equator surface, the inspection bench offers high resolution images with a linear resolution of 45 m/pixel at a distance of ∼200 mm. The bench comprises of two major sub-systems, optical imaging system and cavity positioning system. A digital camera and multi coloured illumination system is used to obtain high resolution images. The camera is mounted inside a long cylindrical tube. The cylindrical tube can be inserted into a SCRF cavity. The length of the cylinder is long enough to inspect five-cell 650 MHz SCRF cavity. The cavity is placed on a set of PTFE rollers, which are mounted on a trolley. The cavity can be moved linearly with the help of ball screw-servomotor mechanism. The camera along with cylindrical tube can be rotated around its axis with a stepper motor to scan the cavity's internal surface. The paper presents the details about the optical inspection bench and optical inspection results. (author)

  3. RF Tests of an 805 MHz Pillbox Cavity at Lab G of Fermilab

    International Nuclear Information System (INIS)

    D. Li; J. Corlett; R. MacGill; M. Zisman; J. Norem; A. Moretti; Z. Qian; J. Wallig; V. Wu; Y. Torun; R.A. Rimmer

    2003-01-01

    We report recent high power RF tests on an 805 MHz RF pillbox cavity with demountable windows over beam apertures at Lab G of Fermilab, a dedicated facility for testing of MUCOOL (muon cooling) components. The cavity is installed inside a superconducting solenoidal magnet. A 12 MW peak RF power klystron is used for the tests. The cavity has been processed both with and without magnetic field. Without magnetic field, a gradient of 34 MV/m was reached rather quickly with very low sparking rate. In a 2.5 T solenoidal field, a 16 MV/m gradient was achieved, following several weeks of conditioning. Strong multipacting effects associated with high radiation levels were measured during processing with the magnetic field. More recently Be windows with TiN-coated surface have been installed and tested with and without the external magnetic field. 16 MV/m gradient without magnetic field was reached quickly as planned. Less multipacting was observed during the conditioning, indicating that the TiN-coated surface on the windows had indeed helped to reduce the secondary electron emission significantly. A gradient of 16.5 MV/m was finally achieved with magnet on in solenoidal mode and the field up to 4 T. Preliminary inspection of the Be window surface found no visual damage, in comparison with Cu windows where substantial surface damage was found. Preliminary understanding of conditioning the cavity in a strong magnetic field has been developed. More thorough window and cavity surface inspection is under way

  4. RF tests of an 805 MHz pillbox cavity at Lab G of Fermilab

    International Nuclear Information System (INIS)

    Li, Derun; Corlett, J.; MacGill, R.; Wallig, J.; Zisman, M.; Moretti, A.; Qian, Z.; Wu, V.; Rimmer, R.; Norem, J.; Torun, Y.

    2003-01-01

    We report recent high power RF tests on an 805 MHz RF pillbox cavity with demountable windows for beam apertures at Lab G of Fermilab, a dedicated facility for testing of MUCOOL (muon cooling) components. The cavity is installed inside a superconducting solenoidal magnet. A 12 MW peak RF power klystron is used for the tests. The cavity has been processed both with and without magnetic field. Without magnetic field, a gradient of 34 MV/m was reached rather quickly with very low sparking rate. In a 2.5 T solenoidal field, a 16 MV/m gradient was achieved, and it had to take many weeks of conditioning. Strong multipacting effects associated with high radiation levels were measured during the processing with the magnetic field. More recently Be windows with TiN-coated surface have been installed and tested at conditions of with and without the external magnetic field. A conservative 16 MV/m gradient without magnetic field was reached quickly as planned. Less multipacting was observed during the conditioning, it indicated that the TiN-coated surface on the windows had indeed helped to reduce the secondary electron emissions significantly. A modest gradient of 16.5 MV/m was finally achieved with magnet on in solenoidal mode and the field up to 4 T. Preliminary inspection on Be windows surface found no damage at all, in comparison with Cu windows where substantial surface damage was found. Preliminary understanding of conditioning cavity in a strong magnetic field has been developed. More through window and cavity surface inspection is under way

  5. Dark current, breakdown, and magnetic field effects in a multicell, 805 MHz cavity

    Directory of Open Access Journals (Sweden)

    J. Norem

    2003-07-01

    Full Text Available We present measurements of dark currents and x rays in a six cell 805 MHz cavity, taken as part of an rf development program for muon cooling, which requires high power, high stored energy, low frequency cavities operating in a strong magnetic field. We have done the first systematic study of the behavior of high power rf in a strong (2.5–4 T magnetic field. Our measurements extend over a very large dynamic range in current and provide good fits to the Fowler-Nordheim field emission model assuming mechanical structures produce field enhancements at the surface. The locally enhanced field intensities we derive at the tips of these emitters are very large, (∼10  GV/m, and should produce tensile stresses comparable to the tensile strength of the copper cavity walls and should be capable of causing breakdown events. We also compare our data with estimates of tensile stresses from a variety of accelerating structures. Preliminary studies of the internal surface of the cavity and window are presented, which show splashes of copper with many sharp cone shaped protrusions and wires which can explain the experimentally measured field enhancements. We discuss a “cold copper” breakdown mechanism and briefly review alternatives. We also discuss a number of effects due to the 2.5 T solenoidal fields on the cavity such as altered field emission due to mechanical deformation of emitters, and dark current ring beams, which are produced from the irises by E×B drifts during the nonrelativistic part of the acceleration process.

  6. Effect of High Solenoidal Magnetic Fields on Breakdown Voltages of High Vacuum 805 MHz Cavities

    CERN Document Server

    Moretti, A; Geer, S; Qian, Z

    2004-01-01

    The demonstration of muon ionization cooling by a large factor is necessary to demonstrate the feasilibility of a collider or neutrino factory. An important cooling experiment, MICE [1], has been proposed to demonstrate 10 % cooling which will validate the technology. Ionization cooling is accomplished by passing a high-emittance beam in a multi-Tesla solenoidal channel alternately through regions of low Z material and very high accelerating RF Cavities. To determine the effect of very large solenoidal magnetic fields on the generations of Dark current, X-Rays and breakdown Voltage gradients of vacuum RF cavities, a test facility has been established at Fermilab in Lab G. This facility consists of a 12 MW 805 MHz RF station, and a large bore 5 T solenoidal superconducting magnet containing a pill box type Cavity with thin removable window apertures allowing dark current studies and breakdown studies of different materials. The results of this study will be presented. The study has shown that the peak achievab...

  7. Design and development progress of a LLRF control system for a 500 MHz superconducting cavity

    Science.gov (United States)

    Lee, Y. S.; Kim, H. W.; Song, H. S.; Lee, J. H.; Park, K. H.; Yu, I. H.; Chai, J. S.

    2012-07-01

    The LLRF (low-level radio-frequency) control system which regulates the amplitude and the phase of the accelerating voltage inside a RF cavity is essential to ensure the stable operation of charged particle accelerators. Recent advances in digital signal processors and data acquisition systems have allowed the LLRF control system to be implemented in digitally and have made it possible to meet the higher demands associated with the performance of LLRF control systems, such as stability, accuracy, etc. For this reason, many accelerator laboratories have completed or are completing the developments of digital LLRF control systems. The digital LLRF control system has advantages related with flexibility and fast reconfiguration. This paper describes the design of the FPGA (field programmable gate array) based LLRF control system and the status of development for this system. The proposed LLRF control system includes an analog front-end, a digital board (ADC (analog to digital converter), DAC (digital to analog converter), FPGA, etc.) and a RF & clock generation system. The control algorithms will be implemented by using the VHDL (VHSIC (very high speed integrated circuits) hardware description language), and the EPICS (experiment physics and industrial control system) will be ported to the host computer for the communication. In addition, the purpose of this system is to control a 500 MHz RF cavity, so the system will be applied to the superconducting cavity to be installed in the PLS storage ring, and its performance will be tested.

  8. Testing of inductive output tube based RF amplifier for 650 MHz SRF cavities

    International Nuclear Information System (INIS)

    Mandal, A.; Som, S.; Manna, S.K.; Ghosh, S.; Seth, S.; Thakur, S.K.; Saha, S.; Panda, U.S.

    2012-01-01

    A 650 MHz IOT based RF amplifier has been developed in VECC. It can be used to power several cavity modules in high energy high current proton linear accelerator to be built for ADSS programme in India and in Project-X at Fermilab, USA. The IOT based amplifier requires different powers supplies, water cooling and forced air cooling for its operation. A Programmable Logic Controller (PLC) based interlocks has been incorporated to take care of systematic on/off of the power supplies and driver amplifier, water flow, air flow and other interlocks for the safe operation of the RF System. In addition to that EPICS based RF operating console and data logging/monitoring system has been added. (author)

  9. Final module tuning of the 805 MHz side-coupled cavities for the Fermilab linac group

    International Nuclear Information System (INIS)

    Qian, Z.; Champion, M.; Miller, H.W.; Moretti, A.; Padilla, R.

    1992-01-01

    As part of the Fermilab Tevatron collider upgrade program the last four linac drift-tube tanks are to be replaced with seven side-coupled cavity modules that will operate at an accelerating gradient of 8 MV/V. Each module is composed of four accelerating sections connected by three bridge couplers and is driven by a 12 MW 805 MHz klystron rf power supply. Sixteen accelerating cells and fifteen coupling cells are brazed into an accelerating section. The modules were tuned such that the π/2 mode of each section and the TM 010 mode of the individual bridge coupler agreed within 2 KHz of the module accelerating mode, the accelerating cell frequency was tuned within ± % KHz and the section stopbands were 50-100 KHz under vacuum. The main cell rms field deviation was in general <1% within any section and the section average rms field deviation was in all but one case <1%. The phase shift from section to section was tuned to <1 degree. The coupling between waveguide and cavity was tuned to match the 30 ma beam loading. 3 tabs., 4 figs., 6 refs

  10. Design, Fabrication and Testing of Medium-Beta 650 MHz SRF Cavity Prototypes for Project-X

    International Nuclear Information System (INIS)

    Marhauser, F.; Clemens, W.A.; Henry, J.; Kneisel, P.; Martin, R.; Rimmer, R.A.; Slack, G.; Turlington, L.; Williams, R.S.

    2011-01-01

    A new type of superconducting radio frequency (SRF) cavity shape with a shallow equator dome to reduce electron impact energies for suppressing multipacting barriers has been proposed. The shape is in consideration for the first time in the framework of Project-X to design a potential multi-cell cavity candidate for the medium-beta section of the SRF proton CW linac operating at 650 MHz. Rationales covering the design of the multi-cell cavity, the manufacture, post-processing and high power testing of two single-cell prototypes are presented.

  11. A 201 MHz RF cavity design with non-stressed pre-curved Be windows for muon cooling channels

    International Nuclear Information System (INIS)

    Li, Derun; Ladran, A.; Staples, J.; Virostek, S.; Zisman, M.; Lau, W.; Yang, S.; Rimmer, R.A.

    2003-01-01

    We present a 201-MHz RF cavity design for muon cooling channels with non-stressed and pre-curved Be foils to terminate the beam apertures. The Be foils are necessary to improve the cavity shunt impedance with large beam apertures needed for accommodating large transverse size muon beams. Be is a low-Z material with good electrical and thermal properties. It presents an almost transparent window to muon beams, but terminates the RF cavity electro-magnetically. Previous designs use pre-stressed flat Be foils in order to keep cavity from detuning resulted from RF heating on the window surface. Be foils are expensive, and it is difficult to make them under desired tension. An alternative design is to use pre-curved and non-stressed Be foils where the buckling direction is known, and frequency shifts can be properly predicted. We will present mechanical simulations on the Be foils in this paper

  12. Design and Development of an Octopus Thermometric system for the 704 MHZ Single-Cell SPL Cavity at CERN

    CERN Document Server

    Liao, K; Brunner, O; Ciapala, E; Glenat, D; Weingarten, W

    2012-01-01

    The octopus thermometric system is designed for the 704 MHz superconducting proton linac (SPL) cavity to detect hot spots and X-rays caused by normal conducting defects and the impact of emission electrons. This system features an octopus body and tentacle structure for good contact with the cavity and easy assembly, a multiplexing circuit with integrated microprocessor for efficient readout and a high density temperature sensor arrangement in order to complete a high resolution temperature and X-ray map. The first prototype is being manufactured and investigations are undergoing for further development.

  13. Study of the beam-cavity interaction in the CERN PS 10 MHz cavities and investigation of hardware solutions to reduce beam loading

    CERN Document Server

    AUTHOR|(CDS)2086984; Palumbo, Luigi

    In the Proton Synchrotron (PS), where the LHC protons longitudinal structure (bunch spacing) is determined as the result of a sophisticated series of Radio Frequency (RF) gymnastics, collective effects were identified as a major limitation to the achievable beam current delivered to the LHC. Dedicated machine development studies pointed out the RF cavities to be one of the major source of instability in the PS. In particular, the 10 MHz RF system, responsible for beam acceleration, was identified as the most probable impedance source in the machine. The cavity impedance limits the circulating intensity in the accelerator since the beam-induced voltage could trigger longitudinal instabilities causing beam losses. For this reason the cavity impedance seen by the beam must be kept as low as possible. In the framework of the LHC Injector Upgrade (LIU) project, the present PS 10 MHz RF system requires an upgrade, in order to reach higher beam intensities and to reduce beam loading. This thesis focuses on the impro...

  14. Study of thermal interaction between a 150 kW CW power coupler and a superconducting 704 MHz elliptical cavity

    Energy Technology Data Exchange (ETDEWEB)

    Souli, M. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France)]. E-mail: souli@ipno.in2p3.fr; Fouaidy, M. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France); Saugnac, H. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France); Szott, P. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France); Gandolfo, N. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France); Bousson, S. [Institut de Physique Nucleaire d' Orsay, CNRS/IN2P3, Orsay (France); Braud, D. [CEA Saclay, DSM/DAPNIA/SACM, 91191 Gif sur Yvette (France); Charrier, J.P. [CEA Saclay, DSM/DAPNIA/SACM, 91191 Gif sur Yvette (France); Roudier, D. [CEA Saclay, DSM/DAPNIA/SACM, 91191 Gif sur Yvette (France); Sahuquet, P. [CEA Saclay, DSM/DAPNIA/SACM, 91191 Gif sur Yvette (France); Visentin, B. [CEA Saclay, DSM/DAPNIA/SACM, 91191 Gif sur Yvette (France)

    2006-07-15

    The power coupler needed for {beta} = 0.65 SRF elliptical cavities dedicated to the driver of XADS (eXperimental Accelerator Driven System) should transmit a CW RF power of 150 kW to a 10 mA proton beam. The estimated average values of the RF losses in the coupler are 130 W (respectively 46 W) for the inner (respectively outer) conductor in SW mode. Due to such high values of the RF losses, it is necessary to very carefully design and optimize the cooling circuits of the coupler in order to efficiently remove the generated heat and to reduce the thermal load to the cavity operating at T = 2 K. An experiment simulating the thermal interaction between the power coupler and a 704 MHz SRF five cells cavity was performed in the CRYHOLAB test facility in order to determine the critical heat load that can be sustained by the cavity without degradation of its RF performance. Experimental data are compared to numerical simulation results obtained with the Finite Element Method code COSMOS/M. These data allow us also to perform in situ measurements of the thermal parameters needed in the thermal model of the coupler (thermal conductivity, thermal contact resistance). These data are used to validate numerical simulations.

  15. RF properties of 700 MHz, β = 0.42 elliptical cavity for high current ...

    Indian Academy of Sciences (India)

    Accelerator and Pulse Power Division, Bhabha Atomic Research Centre, ... has been taken up as a part of the accelerator-driven subcritical system project. ... cavity's peak electric and magnetic fields, power dissipation Pc, quality factor Q and.

  16. Higher Order Mode (HOM) Impedance and Damping Study for the LHC Capture Cavity

    CERN Document Server

    Linnecar, Trevor Paul R; Tückmantel, Joachim; CERN. Geneva. SPS and LHC Division

    2001-01-01

    To investigate the higher order mode, HOM, damping in the LHC 200MHz ACN cavity when using four HOM couplers, simulations have been done by both 3-D frequency domain and time domain methods. These simulations have previously been used in other studies of HOM damped cavities and shown to be effective by comparing measurement and simulation results[1] [2]. Using these methods the impedance spectrum of the HOM modes in the cavity before and after damping has been obtained. From this, detailed information about the HOM coupler's contribution to HOM damping can be obtained. The distribution and magnitude of some potentially dangerous HOM modes in the ACN cavity have been found.

  17. RF properties of 700 MHz, β= 0.42 elliptical cavity for high current ...

    Indian Academy of Sciences (India)

    ADSS) that will be mainly utilized for the transmutation of nuclear waste and enrichment of U233. Design and development of superconducting medium velocity cavity has been taken up as a part of the accelerator-driven subcritical system ...

  18. Acne vulgaris.

    Science.gov (United States)

    Moradi Tuchayi, Sara; Makrantonaki, Evgenia; Ganceviciene, Ruta; Dessinioti, Clio; Feldman, Steven R; Zouboulis, Christos C

    2015-09-17

    Acne vulgaris is a chronic inflammatory disease - rather than a natural part of the life cycle as colloquially viewed - of the pilosebaceous unit (comprising the hair follicle, hair shaft and sebaceous gland) and is among the most common dermatological conditions worldwide. Some of the key mechanisms involved in the development of acne include disturbed sebaceous gland activity associated with hyperseborrhoea (that is, increased sebum production) and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, induction of inflammation and dysfunction of the innate and adaptive immunity. Grading of acne involves lesion counting and photographic methods. However, there is a lack of consensus on the exact grading criteria, which hampers the conduction and comparison of randomized controlled clinical trials evaluating treatments. Prevention of acne relies on the successful management of modifiable risk factors, such as underlying systemic diseases and lifestyle factors. Several treatments are available, but guidelines suffer from a lack of data to make evidence-based recommendations. In addition, the complex combination treatment regimens required to target different aspects of acne pathophysiology lead to poor adherence, which undermines treatment success. Acne commonly causes scarring and reduces the quality of life of patients. New treatment options with a shift towards targeting the early processes involved in acne development instead of suppressing the effects of end products will enhance our ability to improve the outcomes for patients with acne.

  19. Dynamics and performance of the free electron laser at Super-Aco with a harmonic RF cavity set on 500 MHz

    International Nuclear Information System (INIS)

    Nutarelli, D.

    2000-01-01

    This work is dedicated to the development of the potentialities of the free electron laser that has been installed on the storage ring Super-Aco at Orsay university. We have studied the dynamics of the electron beam inside a harmonic RF cavity set on 500 MHz. The impact of the geometric characteristics of the optical cavity on the transverse overlapping between laser radiation and the electron beam has been studied in details. An important part of the work has been the assessment of the optical characterization of the dielectric multi-layer mirrors of the cavity. For that purpose a complete system has been designed to assess the changes in optical properties of mirrors during laser operation. Another important part of this work was the study of the interaction process between laser radiation and the electron bunch leading to saturation. This interaction process has been simulated through a new model and some predictions given by this model have been successfully confronted to experimental data. The installation of the harmonic RF cavity has led to a significant increase of the laser radiation gain and the value of the mean power of the laser radiation has reached 300 mW. An interesting application of this technique is the generation of high energy gamma photons through Compton backscattering. A collimated 35 MeV-energy photon beam has been produced at Super-Aco with a rate of 5.10 6 photons per second. (A.C.)

  20. High power tests of the prototype 352 MHz beta 0.85 five cell cavity for the TRASCO project

    International Nuclear Information System (INIS)

    Chiaveri, E.; Losito, R.; Calatroni, S.

    2003-01-01

    The Five-cell beta 0.85 cavities built at CERN for the development of the TRASCO project is fully tested at the CERN SL-CT Test Bench. The cavity, built using the standard Niobium on Copper technique, was previously tested in a vertical cryostat, showing Qo and Field exceeding the design goal for the TRASCO Project (2.5x10 9 and 5.5 MV/m at 4.5 K). After the successful test we decided to check the performances of the cavity installed in a horizontal Cryostat and equipped with a LEP-II Type high power main coupler and HOM couplers. The cavity was equipped with the Helium Tank, Tuners and couplers at CERN and tested at the SL-CT facility at CERN under a collaboration agreement between INFN and CERN. The behavior of the fully equipped cavity substantially confirmed the results of the preliminary production tests in the vertical Cryostat. The quality factor at low field was substantially unchanged. No MP activity was detected confirming the soundness of the design and the quality of the surface treatment. (author)

  1. Second Sound Measurement using SMD resistors to simulate Quench locations on the 704 MHZ Single-Cell Cavity at CERN

    CERN Document Server

    Liao, K; Ciapala, E; Junginger, T; Weingarten, W

    2012-01-01

    Oscillating Superleak Transducers (OSTs) containing flexible porous membranes are widely used to detect the so-called second sound temperature wave when a quench event occurs in a superconducting RF cavity. In principle, from the measured speed of this wave and the travel time between the quench event and several OSTs, the location of the quench sites can be derived by triangulation. Second sound behaviour has been simulated through different surface mount (SMD) resistors setups on a Superconducting Proton Linac (SPL) test cavity, to help understanding the underlying physics and improve quench localisation. Experiments are described that have been conducted to search for explanation of heat transfer during cavity quench that causes contradictory triangulation results.

  2. A compact 10 kW, 476 MHz solid state radio frequency amplifier for pre-buncher cavity of free electron laser injector linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Mohania, Praveen; Mahawar, Ashish; Shrivastava, Purushottam; Gupta, P. D. [Raja Rammana Centre for Advanced Technology (RRCAT), Indore 452013 (India)

    2013-09-15

    A 10 kW, 476 MHz, 0.1% duty cycle solid state RF amplifier system for driving sub-harmonic, pre-buncher cavity of IR-FEL injector LINAC, has been developed at RRCAT. The 10 kW power is achieved by combining output of eight 1400 W amplifier modules using 8-way planar corporate combiner. The solid state amplifier modules have been developed using 50 V RF LDMOS transistors which although meant for push-pull operation are being used in single ended configuration with matching circuit developed on a thin (25 mils), high dielectric constant (9.7), low loss microwave laminate with an aim to have a compact structure. Ease of fabrication, modularity, small size, and low cost are the important features of this design which could be used as a template for low duty cycle medium to high pulsed power UHF amplifier system.

  3. Can I Prevent Acne?

    Science.gov (United States)

    ... for Educators Search English Español Can I Prevent Acne? KidsHealth / For Teens / Can I Prevent Acne? Print en español ¿Puedo prevenir el acné? What Causes Acne? Contrary to what you may have heard, acne ...

  4. What Is Acne?

    Science.gov (United States)

    ... Topics Acne English Español 繁體中文 한국어 tiếng Việt Acne Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Acne Doctors don’t know what causes acne, but ...

  5. Dark chocolate exacerbates acne.

    Science.gov (United States)

    Vongraviopap, Saivaree; Asawanonda, Pravit

    2016-05-01

    The effects of chocolate on acne exacerbations have recently been reevaluated. For so many years, it was thought that it had no role in worsening acne. To investigate whether 99% dark chocolate, when consumed in regular daily amounts, would cause acne to worsen in acne-prone male subjects, twenty-five acne prone male subjects were asked to consume 25 g of 99% dark chocolate daily for 4 weeks. Assessments which included Leeds revised acne scores as well as lesion counts took place weekly. Food frequency questionnaire was used, and daily activities were recorded. Statistically significant changes of acne scores and numbers of comedones and inflammatory papules were detected as early as 2 weeks into the study. At 4 weeks, the changes remained statistically significant compared to baseline. Dark chocolate when consumed in normal amounts for 4 weeks can exacerbate acne in male subjects with acne-prone skin. © 2015 The International Society of Dermatology.

  6. Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris.

    Science.gov (United States)

    Liu, Pei-Feng; Hsieh, Yao-Dung; Lin, Ya-Ching; Two, Aimee; Shu, Chih-Wen; Huang, Chun-Ming

    2015-01-01

    Acne vulgaris, a multi-factorial disease, is one of the most common skin diseases, affecting an estimated 80% of Americans at some point during their lives. The gram-positive and anaerobic Propionibacterium acnes (P. acnes) bacterium has been implicated in acne inflammation and pathogenesis. Therapies for acne vulgaris using antibiotics generally lack bacterial specificity, promote the generation of antibiotic-resistant bacterial strains, and cause adverse effects. Immunotherapy against P. acnes or its antigens (sialidase and CAMP factor) has been demonstrated to be effective in mice, attenuating P. acnes-induced inflammation; thus, this method may be applied to develop a potential vaccine targeting P. acnes for acne vulgaris treatment. This review summarizes reports describing the role of P. acnes in the pathogenesis of acne and various immunotherapy-based approaches targeting P. acnes, suggesting the potential effectiveness of immunotherapy for acne vulgaris as well as P. acnes-associated diseases.

  7. Acne vulgaris: endocriene aspecten

    NARCIS (Netherlands)

    Dekkers, O. M.; Thio, B. H.; Romijn, J. A.; Smit, J. W. A.

    2006-01-01

    Androgens play an important part in the development of acne vulgaris. Androgen levels in patients with acne are higher than those in controls and people with the androgen insensitivity syndrome do not develop acne. Local factors other than androgen plasma levels, also play a part in the development

  8. Fabrication and Final Field Tuning of Copper Cavity Models for a High-Current SRF ERL at 703.75 MHz

    CERN Document Server

    Cole, Michael; Burger, Al; Falletta, Michael; Holmes, Douglas; Peterson, Ed; Wong, Robert

    2005-01-01

    Advanced Energy Systems is currently under contract to BNL to fabricate a five cell superconducting cavity and cryomodule for the RHIC eCooler SRF Energy Recovery Linac (ERL) program.* The cavity is designed and optimized for ampere class SRF ERL service. As part of this program, we have fabricated two low power copper models of the RF cavities. During the fabrication process a series of frequency measurements were made and compared to the frequency expected at that point in the fabrication process. Where possible, the cavity was modified either before or during, the next fabrication step to tune the cavity frequency toward the target frequency. Following completion of the cavities they were tuned for field flatness and frequency. This paper will review the measurements made, frequency tuning performed, and discuss discrepancies between the expected and measured results. We will also review the as fabricated field profiles and the results of the tuning steps. Further, the cost and benefits of extensive in pro...

  9. Acne in women.

    Science.gov (United States)

    Ramos-e-Silva, M; Ramos-e-Silva, S; Carneiro, S

    2015-07-01

    This review focuses on the subject of acne in women, a disease that is increasingly common and that can also affect men. Adult acne differs from the type of acne that occurs in teenagers, and it may persist beyond adolescence or have its onset at an older age (adult-onset acne or late acne). Acne can have a negative impact on the quality of life of patients at any age, leading to a negative body image and decrease in self-esteem, and in older patients it can result in discrimination in the workplace and in other social environments. Acne in women must be understood as a specific problem, and here we discuss the pathogenesis, clinical presentation, psychology and treatment of this very prevalent problem. © 2015 British Association of Dermatologists.

  10. Can Acne Scars Be Removed?

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Can Acne Scars Be Removed? KidsHealth / For Teens / Can Acne ... eliminar las cicatrices del acné? Different Types of Acne Scars from acne can seem like double punishment — ...

  11. Testing of super conducting low-beta 704 Mhz cavities at 50 Hz pulse repetition rate in view of SPL- first results

    CERN Document Server

    Höfle, W; Lollierou, J; Valuch, D; Chel, S; Devanz, G; Desmons, M; Piquet, O; Paparella, R; Pierini, P

    2010-01-01

    In the framework of the preparatory phase for the luminosity upgrade of the LHC (SLHC-PP ) it is foreseen to characterize two superconducting RF cavities and demonstrate compliance of the required SPL field stability in amplitude and phase using a prototype LLRF system. We report on the preparation for testing of two superconducting low-beta cavities at 50 Hz pulse repetition rate including the setting-up of the low level RF control system to evaluate the performance of the piezo-tuning system and cavity field stability in amplitude and phase. Results from tests with 50 Hz pulse repetition rate are presented. Simulations of the RF system will be used to predict the necessary specifications for power and bandwidth to control the cavity field and derive specifications for the RF system and its control. Exemplary results of the simulation are presented.

  12. Acne and anticonvulsants.

    Science.gov (United States)

    Greenwood, R; Fenwick, P B; Cunliffe, W J

    1983-01-01

    The severity of acne and rate of excretion of sebum were assessed in 243 patients with epilepsy taking various anticonvulsants who were in hospital long term and in matched controls derived from a normal population of 2176 people. Neither the prevalence of acne nor the sebum excretion rate significantly increased in the patients compared with the controls or in patients taking phenytoin compared with those not. It is concluded that anticonvulsant treatment does not cause acne. PMID:6227369

  13. Sonography of acne vulgaris.

    Science.gov (United States)

    Wortsman, Ximena; Claveria, Pedro; Valenzuela, Fernando; Molina, Maria Teresa; Wortsman, Jacobo

    2014-01-01

    The purpose of this study was to assess the sonographic morphology of the clinical and subclinical pathology of facial acne vulgaris. We studied patients with facial acne vulgaris diagnosed by certified dermatologists, and using a standardized protocol for sonographic examinations, we sequentially described the sonographic pathomorphologic characteristics. Lesions of particular interest to the referring clinician were also analyzed separately. Additionally, acne involvement was staged clinically and sonographically (SOS-Acne) using morphologic definitions of the relevant lesions and predefined scoring systems for gradation of the severity of acne lesions. A total of 245 acne lesions in 20 consecutive patients were studied. Sonographic abnormalities consisted of pseudocysts, folliculitis, fistulas, and calcinosis. Most conditions were subclinical and mostly due to lesion extensions deep into the dermis and hypodermis (52% of pseudocysts and 68% of fistulas). The statistical concordance between acne severity scores assigned by two separate clinicians was strong (κ = 0.8020), but the corresponding sonographic scores generally showed more severe and clinically occult involvement. Facial acne vulgaris often involves deeper tissues, beyond the reach of the spatially restricted clinical examination; these subclinical conditions can be detected and defined with sonography. Additionally, acne vulgaris is amenable to sonographic scoring.

  14. radiofrequency cavity

    CERN Multimedia

    1988-01-01

    The pulse of a particle accelerator. 128 of these radio frequency cavities were positioned around CERN's 27-kilometre LEP ring to accelerate electrons and positrons. The acceleration was produced by microwave electric oscillations at 352 MHz. The electrons and positrons were grouped into bunches, like beads on a string, and the copper sphere at the top stored the microwave energy between the passage of individual bunches. This made for valuable energy savings as it reduced the heat generated in the cavity.

  15. Management strategies for acne vulgaris

    Science.gov (United States)

    Whitney, Kristen M; Ditre, Chérie M

    2011-01-01

    Clinical question: What are the most effective treatment(s) for mild, moderate, severe, and hormonally driven acne? Results: Mild acne responds favorably to topical treatments such as benzoyl peroxide, salicylic acid, and a low-dose retinoid. Moderate acne responds well to combination therapy comprising-topical benzoyl peroxide, antibiotics, and/or retinoids, as well as oral antibiotics in refractory cases and oral contraceptive pills for female acne patients. Severe nodulocystic acne vulgaris responds best to oral isotretinoin therapy. In female patients with moderate to severe acne, facial hair, loss of scalp hair and irregular periods, polycystic ovarian syndrome should be considered and appropriate treatment with hormonal modulation given. Adjunctive procedures can also be considered for all acne patients. Implementation: Pitfalls to avoid when treating acne: treatment of acne in women of child-bearing age; familiarization of all acne treatments in order to individualize management for patients; indications for specialist referral. PMID:21691566

  16. Single-photon emission at a rate of 143 MHz from a deterministic quantum-dot microlens triggered by a mode-locked vertical-external-cavity surface-emitting laser

    Energy Technology Data Exchange (ETDEWEB)

    Schlehahn, A.; Gschrey, M.; Schnauber, P.; Schulze, J.-H.; Rodt, S.; Strittmatter, A.; Heindel, T., E-mail: tobias.heindel@tu-berlin.de; Reitzenstein, S. [Institut für Festkörperphysik, Technische Universität Berlin, Berlin 10623 (Germany); Gaafar, M.; Vaupel, M.; Stolz, W.; Rahimi-Iman, A.; Koch, M. [Department of Physics and Materials Science Center, Philipps-Universität Marburg, 35032 Marburg (Germany)

    2015-07-27

    We report on the realization of a quantum dot (QD) based single-photon source with a record-high single-photon emission rate. The quantum light source consists of an InGaAs QD which is deterministically integrated within a monolithic microlens with a distributed Bragg reflector as back-side mirror, which is triggered using the frequency-doubled emission of a mode-locked vertical-external-cavity surface-emitting laser (ML-VECSEL). The utilized compact and stable laser system allows us to excite the single-QD microlens at a wavelength of 508 nm with a pulse repetition rate close to 500 MHz at a pulse width of 4.2 ps. Probing the photon statistics of the emission from a single QD state at saturation, we demonstrate single-photon emission of the QD-microlens chip with g{sup (2)}(0) < 0.03 at a record-high single-photon flux of (143 ± 16) MHz collected by the first lens of the detection system. Our approach is fully compatible with resonant excitation schemes using wavelength tunable ML-VECSELs, which will optimize the quantum optical properties of the single-photon emission in terms of photon indistinguishability.

  17. Acne -- self-care

    Science.gov (United States)

    ... is no evidence that you need to avoid chocolate, milk, or high-fat foods. High sugar intake ... for severe acne A laser procedure called photodynamic therapy Chemical skin peeling When to Call the Doctor ...

  18. Isotretinoin in acne agminata

    International Nuclear Information System (INIS)

    Daneshpazhooh, M.; Ehsani, A.; Toosi, S.; Robati, Reza M.

    2007-01-01

    Acne agminata is an asymptomatic papulopustular eruption. This condition typically occurs in young adults. The eruption generally runs a self-limited course, but disfiguring scars can occur. Histological examination shows scattered dermal granulomas composed of epitheloid and some giant cells with central caseation. A variety of agents such as wide spectrum antibiotics, oral steroids, dapsone and clofazimine have been used with varying degrees of success. Herein, we report 2 Caucasian males with acne agminata successfully treated with isotretinoin. (author)

  19. Acne and the Internet.

    Science.gov (United States)

    Zeichner, Joshua A; Del Rosso, James Q

    2016-04-01

    The Internet provides both education and miseducation for acne patients. Although some sites provide disease background information and objective treatment guidance, support networks, and research findings, others may seem to be objective on the surface, but are in reality run by untrained, self-proclaimed experts or are promotional in nature. Providers must be aware of the potential benefits and pitfalls the Internet provides for those suffering with acne. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments In every pregnancy, a woman starts out with a 3-5% chance of having a baby ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  1. Evidence on acne therapy

    Directory of Open Access Journals (Sweden)

    Caroline Sousa Costa

    Full Text Available Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin.

  2. Neonatal and infantile acne vulgaris: an update.

    Science.gov (United States)

    Serna-Tamayo, Cristian; Janniger, Camila K; Micali, Giuseppe; Schwartz, Robert A

    2014-07-01

    Acne may present in neonates, infants, and small children. Neonatal and infantile acne vulgaris are not considered to be rare. The presentation of acne in this patient population sometimes represents virilization and may portend later development of severe adolescent acne. Neonatal and infantile acne vulgaris must be distinguished from other cutaneous disorders seen in newborns and infants. Infantile acne tends to be more pleomorphic and inflammatory, thus requiring more vigorous therapy than neonatal acne.

  3. Management strategies for acne vulgaris

    Directory of Open Access Journals (Sweden)

    Whitney KM

    2011-04-01

    Full Text Available Kristen M Whitney1, Chérie M Ditre21Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA; 2Skin Enhancement Center and Cosmetic Dermatology, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USADate of preparation: 30th November 2010Conflicts of interest: None declaredClinical question: What are the most effective treatment(s for mild, moderate, severe, and hormonally driven acne?Results: Mild acne responds favorably to topical treatments such as benzoyl peroxide, salicylic acid, and a low-dose retinoid. Moderate acne responds well to combination therapy comprising-topical benzoyl peroxide, antibiotics, and/or retinoids, as well as oral antibiotics in refractory cases and oral contraceptive pills for female acne patients. Severe nodulocystic acne vulgaris responds best to oral isotretinoin therapy. In female patients with moderate to severe acne, facial hair, loss of scalp hair and irregular periods, polycystic ovarian syndrome should be considered and appropriate treatment with hormonal modulation given. Adjunctive procedures can also be considered for all acne patients.Implementation: Pitfalls to avoid when treating acne: treatment of acne in women of childbearing age; familiarization of all acne treatments in order to individualize management for patients; indications for specialist referral.Keywords: acne vulgaris, benzoyl peroxide, retinoids, antibiotics, light and laser therapy, photodynamic therapy, photopneumatic therapy, chemical peels

  4. Dietary intervention in acne

    Science.gov (United States)

    Melnik, Bodo

    2012-01-01

    The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integrates signals of cellular energy, growth factors (insulin, IGF-1) and protein-derived signals, predominantly leucine, provided in high amounts by milk proteins and meat. mTORC1 activates SREBP, the master transcription factor of lipogenesis. Leucine stimulates mTORC1-SREBP signaling and leucine is directly converted by sebocytes into fatty acids and sterols for sebaceous lipid synthesis. Over-activated mTORC1 increases androgen hormone secretion and most likely amplifies androgen-driven mTORC1 signaling of sebaceous follicles. Testosterone directly activates mTORC1. Future research should investigate the effects of isotretinoin on sebocyte mTORC1 activity. It is conceivable that isotretinoin may downregulate mTORC1 in sebocytes by upregulation of nuclear levels of FoxO1. The role of Western diet in acne can only be fully appreciated when all stimulatory inputs for maximal mTORC1 activation, i.e., glucose, insulin, IGF-1 and leucine, are adequately considered. Epidemic acne has to be recognized as an mTORC1-driven disease of civilization like obesity, type 2 diabetes, cancer and neurodegenerative diseases. These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of

  5. Understanding Acne: How to Banish Breakouts

    Science.gov (United States)

    ... Issues Subscribe January 2010 Print this issue Understanding Acne How to Banish Breakouts Send us your comments ... Protect Your Skin from Sun Damage Wise Choices Acne Flare-ups The exact cause of acne is ...

  6. Radiation measurements during cavities conditioning on APS RF test stand

    International Nuclear Information System (INIS)

    Grudzien, D.M.; Kustom, R.L.; Moe, H.J.; Song, J.J.

    1993-01-01

    In order to determine the shielding structure around the Advanced Photon Source (APS) synchrotron and storage ring RF stations, the X-ray radiation has been measured in the near field and far field regions of the RF cavities during the normal conditioning process. Two cavity types, a prototype 352-MHz single-cell cavity and a 352-MHz five-cell cavity, are used on the APS and are conditioned in the RF test stand. Vacuum measurements are also taken on a prototype 352-MHz single-cell cavity and a 352-MHz five-cell cavity. The data will be compared with data on the five-cell cavities from CERN

  7. In-vivo fluorescence detection and imaging of porphyrin-producing bacteria in the human skin and in the oral cavity for diagnosis of acne vulgaris, caries, and squamous cell carcinoma

    Science.gov (United States)

    Koenig, Karsten; Schneckenburger, Herbert; Hemmer, Joerg; Tromberg, Bruce J.; Steiner, Rudolf W.

    1994-05-01

    Certain bacteria are able to synthesize metal-free fluorescent porphyrins and can therefore be detected by sensitive autofluorescence measurements in the red spectral region. The porphyrin-producing bacterium Propionibacterium acnes, which is involved in the pathogenesis of acne vulgaris, was localized in human skin. Spectrally resolved fluorescence images of bacteria distribution in the face were obtained by a slow-scan CCD camera combined with a tunable liquid crystal filter. The structured autofluorescence of dental caries and dental plaque in the red is caused by oral bacteria, like Bacteroides or Actinomyces odontolyticus. `Caries images' were created by time-gated imaging in the ns-region after ultrashort laser excitation. Time-gated measurements allow the suppression of backscattered light and non-porphyrin autofluorescence. Biopsies of oral squamous cell carcinoma exhibited red autofluorescence in necrotic regions and high concentrations of the porphyrin-producing bacterium Pseudomonas aerigunosa. These studies suggest that the temporal and spectral characteristics of bacterial autofluorescence can be used in the diagnosis and treatment of a variety of diseases.

  8. Quantification of Propionic Acid in the Bovine Spinal Disk After Infection of the Tissue With Propionibacteria acnes Bacteria.

    Science.gov (United States)

    Magnitsky, Sergey; Dudli, Stefan; Tang, Xinyan; Kaur, Jaskanwaljeet; Diaz, Joycelyn; Miller, Steve; Lotz, Jeffrey C

    2018-06-01

    Research. The goal of this study was to investigate whether Propionibacteria acnes infection of the intervertebral disc can be detected noninvasively by nuclear magnetic resonance (NMR) spectroscopy. Microbiological studies of surgical samples suggest that a significant subpopulation of back pain patients may have occult disc infection with P. acnes bacteria. This hypothesis is further supported by a double-blind clinical trial showing that back pain patients with Modic type 1 changes may respond to antibiotic treatment. Because significant side effects are associated with antibiotic treatment, there is a need for a noninvasive method to detect whether specific discs in back pain patients are infected with P acnes bacteria. P. acnes bacteria were obtained from human patients. NMR detection of a propionic acid (PA) in the bacteria extracts was conducted on 500 MHz high-resolution spectrometer, whereas in vivo NMR spectroscopy of an isolated bovine disk tissue infected with P. acnes was conducted on 7 T magnetic resonance imaging scanner. NMR spectra of P. acnes metabolites revealed a distinct NMR signal with identical chemical shits (1.05 and 2.18 ppm) as PA (a primary P. acne metabolite). The 1.05 ppm signal does not overlap with other bacteria metabolites, and its intensity increases linearly with P. acnes concentration. Bovine disks injected with P. acnes bacteria revealed a very distinct NMR signal at 1.05 ppm, which linearly increased with P. acnes concentration. The 1.05 ppm NMR signal from PA can be used as a marker of P. acnes infection of discs. This signal does not overlap with other disc metabolites and linearly depends on P. acnes concentration. Consequently, NMR spectroscopy may provide a noninvasive method to detect disc infection in the clinical setting. N/A.

  9. Is acne caused by colonization with the "wrong" strain of Propionibacterium acnes? A review of the role of Propionibacterium acnes in acne

    DEFF Research Database (Denmark)

    Lomholt, Hans Bredsted; Kilian, Mogens

    2008-01-01

    Acne is still a major problem, and treatment options are far from ideal. A number of studies suggest that the species Propionibacterium acnes plays an important role in the pathogenesis, and new data point towards molecular mechanisms by which the organism is able to trigger the host inflammatory...... response. The current knowledge on P. acnes in relation to acne is reviewed....

  10. Evaluation of Acne Quality of Life and Clinical Severity in Acne Female Adults

    Directory of Open Access Journals (Sweden)

    Amal Kokandi

    2010-01-01

    Full Text Available Acne is a common disease especially among teenagers. It has a considerable psychological impact on affected individuals. The aim of this paper was to assess if the effect of acne on acne-related quality of life is correlated to acne clinical severity. 112 university female students attending the university medical clinics with acne complaints were examined. Cardiff Acne Disability Index (CADI was used to assess acne-related quality of life, and global acne grading system (GAGS was used to assess clinical severity of acne. There was no correlation between acne severity (GAGS scoring system and quality of life impairment as assessed by CADI score (=0.145, =.127. Additionally, CADI score did not correlate with disease duration or age of patients. We therefore conclude that acne clinical severity alone does not affect acne-related quality of life changes. Many other factors might play a role.

  11. Hidradenitis Suppurativa/Acne Inversa

    DEFF Research Database (Denmark)

    Zouboulis, Christos C.; Del Marmol, Véronique; Mrowietz, Ulrich

    2015-01-01

    BACKGROUND: Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating disease, which inflicts a significant burden on patients and is associated with comorbid disorders, such as significantly reduced quality of life, depression, stigmatization, inactivity...

  12. The Psychosocial Impact of Acne Vulgaris

    Science.gov (United States)

    Hazarika, Neirita; Archana, M

    2016-01-01

    Background: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. Aims: To assess the impact of acne on the various psychosocial domains of daily life. Materials and Methods: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI) questionnaire. Results: Females (56%), 15–20 year olds (61%), facial lesions (60%), and Grade II acne (70%) were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6–10) interpreted as moderate effect on patient's life. Statistically significant correlation (P acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne. Limitation: It was a hospital-based study with small sample size. Conclusion: Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment. PMID:27688440

  13. The Psychosocial Impact of Acne Vulgaris.

    Science.gov (United States)

    Hazarika, Neirita; Archana, M

    2016-01-01

    Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. To assess the impact of acne on the various psychosocial domains of daily life. This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI) questionnaire. Females (56%), 15-20 year olds (61%), facial lesions (60%), and Grade II acne (70%) were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6-10) interpreted as moderate effect on patient's life. Statistically significant correlation (P < 0.05) found were as follows: Physical symptoms with grade of acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne. It was a hospital-based study with small sample size. Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.

  14. The psychosocial impact of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Neirita Hazarika

    2016-01-01

    Full Text Available Background: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. Aims: To assess the impact of acne on the various psychosocial domains of daily life. Materials and Methods: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI questionnaire. Results: Females (56%, 15–20 year olds (61%, facial lesions (60%, and Grade II acne (70% were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6–10 interpreted as moderate effect on patient's life. Statistically significant correlation (P < 0.05 found were as follows: Physical symptoms with grade of acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne. Limitation: It was a hospital-based study with small sample size. Conclusion: Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.

  15. The LHC superconducting cavities

    CERN Document Server

    Boussard, Daniel; Häbel, E; Kindermann, H P; Losito, R; Marque, S; Rödel, V; Stirbet, M

    1999-01-01

    The LHC RF system, which must handle high intensity (0.5 A d.c.) beams, makes use of superconducting single-cell cavities, best suited to minimizing the effects of periodic transient beam loading. There will be eight cavities per beam, each capable of delivering 2 MV (5 MV/m accelerating field) at 400 MHz. The cavities themselves are now being manufactured by industry, using niobium-on-copper technology which gives full satisfaction at LEP. A cavity unit includes a helium tank (4.5 K operating temperature) built around a cavity cell, RF and HOM couplers and a mechanical tuner, all housed in a modular cryostat. Four-unit modules are ultimately foreseen for the LHC (two per beam), while at present a prototype version with two complete units is being extensively tested. In addition to a detailed description of the cavity and its ancillary equipment, the first test results of the prototype will be reported.

  16. Acne, vulgaris on the back (image)

    Science.gov (United States)

    Acne frequently occurs on the back. Here, there are 2 to 6 millimeter wide erythematous (red) pustules ... Permanent scarring may follow a severe case of acne. Men are more often affected on their shoulders ...

  17. Acne, cystic on the face (image)

    Science.gov (United States)

    The face is the most common location of acne. Here, there are 4 to 6 millimeter red ( ... scars and fistulous tract formation (connecting passages). Severe acne may have a profound psychological impact and may ...

  18. Niobium superconducting cavity

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    This 5-cell superconducting cavity, made from bulk-Nb, stems from the period of general studies, not all directed towards direct use at LEP. This one is dimensioned for 1.5 GHz, the frequency used at CEBAF and also studied at Saclay (LEP RF was 352.2 MHz). See also 7908227, 8007354, 8209255, 8210054, 8312339.

  19. Current and future treatment options for acne.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Kleinpenning, M.M.; Jong, E.M.G.J. de; Gerritsen, M.J.P.; Dooren-Greebe, R.J. van; Alkemade, J.A.C.

    2006-01-01

    Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented.

  20. Normal Conducting RF Cavity for MICE

    International Nuclear Information System (INIS)

    Li, D.; DeMello, A.; Virostek, S.; Zisman, M.; Summers, D.

    2010-01-01

    Normal conducting RF cavities must be used for the cooling section of the international Muon Ionization Cooling Experiment (MICE), currently under construction at Rutherford Appleton Laboratory (RAL) in the UK. Eight 201-MHz cavities are needed for the MICE cooling section; fabrication of the first five cavities is complete. We report the cavity fabrication status including cavity design, fabrication techniques and preliminary low power RF measurements.

  1. Upgraded cavities for the positron accumulator ring of the APS

    International Nuclear Information System (INIS)

    Kang, Y.W.; Jiang, X.; Mangra, D.

    1997-01-01

    Upgraded versions of cavities for the APS positron accumulator ring (PAR) have been built and are being tested. Two cavities are in the PAR: a fundamental 9.8-MHz cavity and a twelfth harmonic 117.3-MHz cavity. Both cavities have been manufactured for higher voltage operation with improved Q-factors, reliability, and tuning capability. Both cavities employ current-controlled ferrite tuners for control of the resonant frequency. The harmonic cavity can be operated in either a pulsed mode or a CW mode. The rf properties of the cavities are presented

  2. Heredity of acne in Korean patients.

    Science.gov (United States)

    Cho, Eun Byul; Ha, Ji Min; Park, Eun Joo; Kim, Kwang Ho; Kim, Kwang Joong

    2014-10-01

    Acne is a chronic inflammatory disease of the pilocebaceous unit that presents with various spectrum and severity. Genetic backgrounds and environmental factors are also considered to be relevant, but few studies have focused on Korean patients. A cross-sectional epidemiologic study on family history of Korean acne patients was performed to analyze family history of acne, and to compare the severity and characteristics of acne in association with family history. A total of 221 patients were enrolled, 98 male (44.3%) and 123 female (55.7%). Patients were grouped as patients with (A+) or without (A-) family history of acne. In a second analysis, patients with any experience of acne treatment were evaluated. Severity of acne was measured with Burton's grading system and Korean Acne Grading System (KAGS). Female patients had a higher tendency to have family history than males (P = 0.002). Group A+ had statistically significant earlier onset of acne (P = 0.002). In inexperienced patients, patients with family history showed a relatively earlier onset (P = 0.084). This study confirmed the role of heredity in acne. Family history of acne is associated with earlier onset of the disease, and more non-inflammatory lesions. © 2014 Japanese Dermatological Association.

  3. Chemical peels for acne and acne scars in asians: Evidence based review

    Directory of Open Access Journals (Sweden)

    Evangeline B Handog

    2012-01-01

    Full Text Available Chemical peeling is a widely used procedure in the management of acne and acne scars, but there are very few studies on Asian populations who are more prone to develop hyper pigmentation. This article aims to summarize and evaluate the existing studies on the role of chemical peels in the treatment of acne and acne scars among Asians. An online search was conducted to identify prospective studies published in English that evaluated the use of chemical peels in active acne and acne scars in Asian populations. There were six studies for acne and eight studies for acne scars that were identified using our search parameters. Most were single-centre, open label and with small sample sizes. Acne severity was not uniformly reported and the objective outcome measures of some studies were not explicitly reported as well. The general trend of the results of the studies support the safety and efficacy of chemical peels for acne and acne scars including those of darker skin types. The existing studies support the use of chemical peels in the treatment of acne and acne scars in Asians. Further clinical trials with better study design and more subjects are needed to further establish the role of chemical peels in Asian acne patients.

  4. [Diet in pathogenesis of acne vulgaris].

    Science.gov (United States)

    Ozdarska, Katarzyna; Osucha, Karolina; Savitskyi, Stepan; Malejczyk, Jacek; Galus, Ryszard

    2017-10-23

    Acne vulgaris is one of the most common dermatologic condition especially among adolescents. Acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of Propionibacterium acnes. Some of investigations show association between acne and diet. Milk increases the level of IGF-1 leading to the synthesis of androgen-mediated increases sebum production. Chocolate predispose to hyperglycemia and insulinemia which aggravate of acne vulgaris. High levels of omega-6 fatty acids have been associated with increase of acne in contrast to omega-3 fatty acids, which decrease inflammation. Food have huge impact on development and severity of acne and may exert beneficial effect in the treatment of this disorder.

  5. Why Do I Get Acne?

    Science.gov (United States)

    ... to acne. And when you're washing your face, be sure you take the time to remove all of your makeup so it ... home. It also can help to wash your face after you've been ... clear it up at the same time. You can experiment with these to see which ...

  6. BNL 703 MHz SRF cryomodule demonstration

    International Nuclear Information System (INIS)

    Burrill, A.; Ben-Zvi, I.; Calaga, R.; Dalesio, L.; Dottavio, T.; Gassner, D.; Hahn, H.; Hoff, L.; Kayran, D.; Kewisch, J.; Lambiase, R.; Lederle, D.; Litvinenko, V.; Mahler, G.; McIntyre, G.

    2009-01-01

    This paper will present the preliminary results of the testing of the 703 MHz SRF cryomodule designed for use in the ampere class ERL under construction at Brookhaven National Laboratory. The preliminary cavity tests, carried out at Thomas Jefferson Laboratory, demonstrated cavity performance of 20 MV/m with a Qo of 1 x 10 10 , results we expect to reproduce in the horizontal configuration. This test of the entire string assembly will allow us to evaluate all of the additional cryomodule components not previously tested in the VTA and will prepare us for our next milestone test which will be delivery of electrons from our injector through the cryomodule to the beam dump. This will also be the first demonstration of an accelerating cavity designed for use in an ampere class ERL, a key development which holds great promise for future machines

  7. Adult female acne: a new paradigm.

    Science.gov (United States)

    Dréno, B; Layton, A; Zouboulis, C C; López-Estebaranz, J L; Zalewska-Janowska, A; Bagatin, E; Zampeli, V A; Yutskovskaya, Y; Harper, J C

    2013-09-01

    In the adult female, acne is a chronic condition with a substantial negative psychological, social and emotional impact. Based on time of onset, two subtypes of adult female acne are recognized: 'persistent acne' is a continuation of the disease from adolescence, while 'late-onset acne' first presents in adulthood. The morphological characteristics of adult female acne are often distinct from adolescent acne. In adults, inflammatory lesions (particularly papules, pustules and nodules) are generally more prominent on the lower chin, jawline and neck, and comedones are more often closed comedones (micro cysts). Adult acne is mainly mild-to-moderate in severity and may be refractory to treatment. A holistic approach to acne therapy should be taken in adult females, which combines standard treatments with adjunctive therapy and cosmetic use. A number of factors specific to the adult female influence choice of treatment, including the predisposition of older skin to irritation, a possible slow response to treatment, a high likelihood of good adherence, whether of child-bearing age, and the psychosocial impact of the disease. Adherence to therapy should be encouraged through further patient education and a simplified regimen that is tailored to suit the individual patient's needs and lifestyle. This article reviews the specific characteristics of adult female acne, and provides recommendations for acne therapy in this patient group. © 2013 The Authors. Journal of the European Academy of Dermatology and Venereology © 2013 European Academy of Dermatology and Venereology.

  8. Cardiff acne disability index in Sarawak, Malaysia.

    Science.gov (United States)

    Yap, Felix Boon-Bin

    2012-05-01

    Acne is considered a cosmetic nuisance in Malaysia since no insurance coverage is provided for its treatment. Its psychological impact is unknown. The aim of this study is to determine the impact of acne on quality of life and its relationship with severity. A cross-sectional study using the Cardiff acne disability index (CADI) and Global Acne Grading System for acne severity grading was done in three government-run dermatology clinics in Sarawak, Malaysia. The study cohort of 200 patients had a mean CADI score of 5.1. Most of the patients (59.5%) had mild CADI impairment, with the domain of feelings most affected. Patients with a family income 0.05). The correlation between CADI and mild acne severity was low (Pearson correlation coefficient=0.35; pSarawak was moderate and must be addressed. It should be viewed as a psychologically disabling disease requiring optimal management and resource allocation.

  9. SPS accelerating cavity

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    The SPS started up with 2 accelerating cavities (each consisting of 5 tank sections) in LSS3. They have a 200 MHz travelling wave structure (see 7411032 and 7802190) and 750 kW of power is fed to each of the cavities from a 1 MW tetrode power amplifier, located in a surface building above, via a coaxial transmission line. Clemens Zettler, builder of the SPS RF system, is standing at the side of one of the cavities. In 1978 and 1979 another 2 cavities were added and entered service in 1980. These were part of the intensity improvement programme and served well for the new role of the SPS as proton-antiproton collider. See also 7411032, 8011289, 8104138, 8302397.

  10. [Using combined magnetotherapy in patients with acne].

    Science.gov (United States)

    Kul'chitskaia, D B; Orekhova, E M; Vasil'eva, E S

    2004-01-01

    Laser Doppler flowmetry discovered microcirculatory disorders in acne patients. Affected are arterioles as well as capillaries and venules. Combination of magnetotherapy with medication improves microcirculation in acne patients. More marked positive changes occurred in the microcirculatory system due to combined treatment compared to medication therapy only. Thus, laser Doppler flowmetry is a new, noninvasive method of assessing microcirculation in acne patients and can serve an objective criterion of treatment efficacy.

  11. Environmental pollution and acne: Chloracne

    OpenAIRE

    Ju, Qiang; Zouboulis, Christos C; Xia, Longqing

    2009-01-01

    Environmental pollutants can result in a variant of acne called ‘chloracne’. Chloracne is caused by systemic exposure to certain halogenated aromatic hydrocarbons ‘chloracnegens’, and is considered to be one of the most sensitive indicators of systemic poisoning by these compounds. Dioxin is the most potent environmental chloracnegen. Most cases of chloracne have resulted from occupational and non-occupational exposures, non-occupational chloracne mainly resulted from contaminated industrial ...

  12. Ultrasensitive and broadband magnetometry with cavity optomechanics

    DEFF Research Database (Denmark)

    Li, Bei-Bei; Bulla, Douglas; Bilek, Jan

    2017-01-01

    We achieved sensitivity of 30 pT/Hz1/2 and working bandwidth larger than 100 MHz, using cavity optomechanical magnetometry, and also demonstrated quantum light enhanced sensitivity in such a magnetometer.......We achieved sensitivity of 30 pT/Hz1/2 and working bandwidth larger than 100 MHz, using cavity optomechanical magnetometry, and also demonstrated quantum light enhanced sensitivity in such a magnetometer....

  13. Superconducting cavities for HERA

    International Nuclear Information System (INIS)

    Dwersteg, B.; Ebeling, W.; Moeller, W.D.; Renken, D.; Proch, D.; Sekutowicz, J.; Susta, J.; Tong, D.

    1988-01-01

    Superconducting 500 MHz cavities are developed to demonstrate the feasibility of upgrading the e-beam energy of the HERA storage ring. A prototype module with 2 x 4 cell resonators and appropriate fundamental and higher mode couplers has been designed at DESY and is being built by industrial firms. The design and results of RF and cryogenic measurements are reported in detail. 17 references, 10 figures, 2 tables

  14. Single-cell LEP-type cavity on measurement stand

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    A single-cell cavity, made of copper, with tapered connectors for impedance measurements. It was used as a model of LEP-type superconducting cavities, to investigate impedance and higher-order modes and operated at around 600 MHz (the LEP acceleration frequency was 352.2 MHz). See 8202500.

  15. Standard guidelines of care for acne surgery

    Directory of Open Access Journals (Sweden)

    Khunger Niti

    2008-03-01

    Full Text Available Acne surgery is the use of various surgical procedures for the treatment of postacne scarring and also, as adjuvant treatment for active acne. Surgery is indicated both in active acne and post-acne scars. Physicians′ qualifications: Any Dermatologist can perform most acne surgery techniques as these are usually taught during postgraduation. However, certain techniques such as dermabrasion, laser resurfacing, scar revisions need specific "hands-on" training in appropriate training centers. Facility: Most acne surgery procedures can be performed in a physician′s minor procedure room. However, full-face dermabrasion and laser resurfacing need an operation theatre in a hospital setting. Active acne: Surgical treatment is only an adjunct to medical therapy, which remains the mainstay of treatment. Comedone extraction is a process of applying simple mechanical pressure with a comedone extractor, to extract the contents of the blocked pilosebaceous follicle. Superficial chemical peel is a process of applying a chemical agent to the skin, so as to cause controlled destruction of the epidermis leading to exfoliation. Glycolic acid, salicylic acid and trichloroacetic acid are commonly used peeling agents for the treatment of active acne and superficial acne scars. Cryotherapy: Cryoslush and cryopeel are used for the treatment of nodulocystic acne. Intralesional corticosteroids are indicated for the treatment of nodules, cysts and keloidal acne scars. Nonablative lasers and light therapy using Blue light, non ablative radiofrequency, Nd:YAG laser, IPL (Intense Pulsed Light, PDT (Photodynamic Therapy, pulse dye laser and light and heat energy machines have been used in recent years for the treatment of active inflammatory acne and superficial acne scars. Proper counseling is very important in the treatment of acne scars. Treatment depends on the type of acne scars; a patient may need more than one type of treatment. Subcision is a treatment to break the

  16. SPS RF Accelerating Cavity

    CERN Multimedia

    1979-01-01

    This picture shows one of the 2 new cavities installed in 1978-1979. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also increased: to the first 2 MW plant a second 2 MW plant was added and by end 1979 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412016X, 7412017X, 7411048X

  17. New achievements in RF cavity manufacturing

    International Nuclear Information System (INIS)

    Lippmann, G.; Pimiskern, K.; Kaiser, H.

    1993-01-01

    Dornier has been engaged in development, manufacturing and testing of Cu-, Cu/Nb- and Nb-cavities for many years. Recently, several different types of RF cavities were manufactured. A prototype superconducting (s.c.) B-Factory accelerating cavity (1-cell, 500 MHz) was delivered to Cornell University, Laboratory of Nuclear Studies. A second lot of 6 s.c. cavities (20-cell, 3000 MHz) was fabricated on contract from Technical University of Darmstadt for the S-DALINAC facility. Finally, the first copper RF structures (9-cell, 1300 MHz) for TESLA were finished and delivered to DESY, two s.c. niobium structures of the same design are in production. Highlights from the manufacturing processes of these cavities are described and first performance results will be reported

  18. Status of 174 MHz RF system for BEP

    International Nuclear Information System (INIS)

    Biryuchevsky, Yu.A.; Gorniker, E.I.; Kendjebulatov, E.K.; Krutikhin, S.A.; Kurkin, G.Ya.; Petrov, V.M.; Pilan, A.M.

    2012-01-01

    The new RF system for the BEP storage ring (which is an injector of VEPP-2000 accelerating complex) will increase the particles energy in the BEP from 0.9 to 1 GeV. RF system operates at a frequency of 174 MHz and consists of an accelerating cavity, RF power generator and control system.

  19. LEP Radio Frequency Copper Cavity

    CERN Multimedia

    The pulse of a particle accelerator. 128 of these radio frequency cavities were positioned around CERN's 27-kilometre LEP ring to accelerate electrons and positrons. The acceleration was produced by microwave electric oscillations at 352 MHz. The electrons and positrons were grouped into bunches, like beads on a string, and the copper sphere at the top stored the microwave energy between the passage of individual bunches. This made for valuable energy savings as it reduced the heat generated in the cavity.

  20. The flexible gene pool of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Brüggemann, Holger; Lomholt, Hans B; Kilian, Mogens

    2012-01-01

    Propionibacterium acnes is a Gram-positive bacterium that is intimately associated with humans. The nature and consequences of this symbiosis are poorly understood; it might comprise both mutualistic and parasitic properties. Recent advances in distinguishing phylotypes of P. acnes have revealed ...

  1. Acne | Lambert | South African Family Practice

    African Journals Online (AJOL)

    Acne vulgaris is a common skin condition with a high prevalence in teenagers and young adults. It is a condition of the pilosebaceous follicles, resulting in comedones, papules, pustules or nodules which occur primarily on the face, but which may also present on other areas of the body. Although acne is not physically ...

  2. Elliptical superconducting RF cavities for FRIB energy upgrade

    Science.gov (United States)

    Ostroumov, P. N.; Contreras, C.; Plastun, A. S.; Rathke, J.; Schultheiss, T.; Taylor, A.; Wei, J.; Xu, M.; Xu, T.; Zhao, Q.; Gonin, I. V.; Khabiboulline, T.; Pischalnikov, Y.; Yakovlev, V. P.

    2018-04-01

    The multi-physics design of a five cell, βG = 0 . 61, 644 MHz superconducting elliptical cavity being developed for an energy upgrade in the Facility for Rare Isotope Beams (FRIB) is presented. The FRIB energy upgrade from 200 MeV/u to 400 MeV/u for heaviest uranium ions will increase the intensities of rare isotope beams by nearly an order of magnitude. After studying three different frequencies, 1288 MHz, 805 MHz, and 644 MHz, the 644 MHz cavity was shown to provide the highest energy gain per cavity for both uranium and protons. The FRIB upgrade will include 11 cryomodules containing 5 cavities each and installed in 80-meter available space in the tunnel. The cavity development included extensive multi-physics optimization, mechanical and engineering analysis. The development of a niobium cavity is complete and two cavities are being fabricated in industry. The detailed design of the cavity sub-systems such as fundamental power coupler and dynamic tuner are currently being pursued. In the overall design of the cavity and its sub-systems we extensively applied experience gained during the development of 650 MHz low-beta cavities at Fermi National Accelerator Laboratory (FNAL) for the Proton Improvement Plan (PIP) II.

  3. Self-reported acne is not associated with prostate cancer

    NARCIS (Netherlands)

    Cremers, R.G.; Aben, K.K.; Verrneulen, S.H.; den Heijer, M.; van Oort, I.M.; van de Kerkhof, P.C.; Schalken, JA; Kiemeney, L.A.

    2014-01-01

    Objective: Some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium Propionibacterium acnes and prostate cancer (PCa). Self-reported acne might be an easily obtainable marker to identify men at relatively low risk of PCa and might be incorporated into

  4. Self-reported acne is not associated with prostate cancer

    NARCIS (Netherlands)

    Cremers, R.G.H.M.; Aben, K.K.H.; Vermeulen, S.; Heijer, M. den; Oort, I.M. van; Kerkhof, P.C.M. van de; Schalken, J.A.; Kiemeney, L.A.L.M.

    2014-01-01

    OBJECTIVE: Some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium Propionibacterium acnes and prostate cancer (PCa). Self-reported acne might be an easily obtainable marker to identify men at relatively low risk of PCa and might be incorporated into

  5. 21 CFR 333.350 - Labeling of acne drug products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Labeling of acne drug products. 333.350 Section... Acne Drug Products § 333.350 Labeling of acne drug products. (a) Statement of identity. The labeling of the product contains the established name of the drug, if any, and identifies the product as an “acne...

  6. Preliminary simulation studies of accelerator cavity loading

    International Nuclear Information System (INIS)

    Faehl, R.J.

    1980-06-01

    Two-dimensional simulations of loading effects in a 350 MHz accelerator cavity have been performed. Electron currents of 1-10 kA have been accelerated in 5 MV/m fields. Higher order cavity modes induced by the beam may lead to emittance growth. Operation in an autoaccelerator mode has been studied

  7. 352.2 MHz rf system for the ESRF

    International Nuclear Information System (INIS)

    Jacob, J.; David, C.

    1988-01-01

    This paper reports that ESRF's 352.2 MHz RF system that uses 1 MW-CW klystrons and five-cell LEP type cavities has been adopted. In the storage ring (SR), two klystrons will feed a total of four cavities in order to provide the maximum required accelerating voltage of 8.9 MV. In the injector synchrotron (SY), two cavities fed by one klystron in a cycling mode at 10 Hz will give the maximum needed accelerating voltage of 7.3 MV. In multibunch operation of the SR, coupled bunch oscillations will be driven by the higher order modes (HOMs) of the cavities, and may limit the maximum beam current to about 60 mA. Spare ports will allow to install HOM dampers on the cavities in order to raise the instability thresholds above the design current of 100 mA. In addition, active feed back systems may be implemented

  8. Acne polimorfo: tratamiento con Implacen

    Directory of Open Access Journals (Sweden)

    Rubén Pérez Armas

    1995-06-01

    Full Text Available Se realiza el estudio de 40 pacientes con acné polimorfo, los que fueron atendidos en la Consulta de Dermatología del Hospital Provincial Clinicoquirúrgico Docente "Celia Sánchez Manduley", en el período comprendido de enero de 1988 a diciembre de 1989. Se revisa la literatura médica sobre los diversos métodos y medicamentos utilizados en la terapéutica de esta dermatosis. Se describe el esquema de tratamiento empleado con implacén en 30 pacientes; los 10 restantes se trataron con placebo; se compara dicho esquema con los tradicionales y se observan mejores resultados con nuestro estudio. Se destaca la ausencia de recaídas, así como el resultado del tratamiento de acuerdo con el sexo.A study was performed in 40 patients presenting with polymorphic acne who were attended in the Dermatology Department of "Celia Sánchez Manduley" Clinicosurgical and Teaching Hospital from January, 1988 to December, 1989. A review of the literature was made seeking for the different methods and drugs used for the treatment of this dermatosis. The treatment schedule with the use of implacen in 30 patients is described. Such therapeutic schedule was compared with traditional ones and better results were observed with the use of implacen. The fact that there were no relapses is highlighted, as well as the result of treatment according to sex.

  9. Complementary therapies for acne vulgaris.

    Science.gov (United States)

    Cao, Huijuan; Yang, Guoyan; Wang, Yuyi; Liu, Jian Ping; Smith, Caroline A; Luo, Hui; Liu, Yueming

    2015-01-19

    Acne is a chronic skin disease characterised by inflamed spots and blackheads on the face, neck, back, and chest. Cysts and scarring can also occur, especially in more severe disease. People with acne often turn to complementary and alternative medicine (CAM), such as herbal medicine, acupuncture, and dietary modifications, because of their concerns about the adverse effects of conventional medicines. However, evidence for CAM therapies has not been systematically assessed. To assess the effects and safety of any complementary therapies in people with acne vulgaris. We searched the following databases from inception up to 22 January 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL; 2014,Issue 1), MEDLINE (from 1946), Embase (from 1974), PsycINFO (from 1806), AMED (from 1985), CINAHL (from 1981), Scopus (from 1966), and a number of other databases listed in the Methods section of the review. The Cochrane CAM Field Specialised Register was searched up to May 2014. We also searched five trials registers and checked the reference lists of articles for further references to relevant trials. We included parallel-group randomised controlled trials (or the first phase data of randomised cross-over trials) of any kind of CAM, compared with no treatment, placebo, or other active therapies, in people with a diagnosis of acne vulgaris. Three authors collected data from each included trial and evaluated the methodological quality independently. They resolved disagreements by discussion and, as needed, arbitration by another author. We included 35 studies, with a total of 3227 participants. We evaluated the majority as having unclear risk of selection, attrition, reporting, detection, and other biases. Because of the clinical heterogeneity between trials and the incomplete data reporting, we could only include four trials in two meta-analyses, with two trials in each meta-analysis. The categories of CAM included

  10. Automated facial acne assessment from smartphone images

    Science.gov (United States)

    Amini, Mohammad; Vasefi, Fartash; Valdebran, Manuel; Huang, Kevin; Zhang, Haomiao; Kemp, William; MacKinnon, Nicholas

    2018-02-01

    A smartphone mobile medical application is presented, that provides analysis of the health of skin on the face using a smartphone image and cloud-based image processing techniques. The mobile application employs the use of the camera to capture a front face image of a subject, after which the captured image is spatially calibrated based on fiducial points such as position of the iris of the eye. A facial recognition algorithm is used to identify features of the human face image, to normalize the image, and to define facial regions of interest (ROI) for acne assessment. We identify acne lesions and classify them into two categories: those that are papules and those that are pustules. Automated facial acne assessment was validated by performing tests on images of 60 digital human models and 10 real human face images. The application was able to identify 92% of acne lesions within five facial ROIs. The classification accuracy for separating papules from pustules was 98%. Combined with in-app documentation of treatment, lifestyle factors, and automated facial acne assessment, the app can be used in both cosmetic and clinical dermatology. It allows users to quantitatively self-measure acne severity and treatment efficacy on an ongoing basis to help them manage their chronic facial acne.

  11. Evaluation of nasal and oropharyngeal flora in patients with acne vulgaris according to treatment options.

    Science.gov (United States)

    Ozuguz, Pınar; Callioglu, Elif E; Tulaci, Kamil G; Kacar, Seval D; Balta, Ilknur; Asik, Gulsah; Karatas, Serap; Karaca, Semsettin

    2014-11-01

    The aim of this study was to evaluate changes in nasal and oropharyngeal flora in patients with acne during treatments with tetracycline and isotretinoin. Swab specimens were taken from the right and left nasal cavities and oropharynx of 55 patients with acne and 20 healthy volunteers who were admitted to the dermatology department (Etlik Educational and Research Hospital, Ankara, Turkey) before the administration of treatment and in the third month of treatment. Study participants were divided into four groups as follows: patients with acne on topical treatment only, systemic isotretinoin, and systemic tetracycline, and the control group. Of 55 patients with acne, 18 were male and 37 were female. The mean age of the patients and the control group was 22.21 ± 4.22 and 21.95 ± 7.64, respectively. Staphylococcus aureus was isolated from the nasal flora of five patients, normal flora was suppressed in the oropharyngeal cultures of seven patients, and normal flora grew in the cultures of the other 20 patients who were on tetracycline treatment. On the other hand, normal flora grew in the nasal and oropharyngeal cultures of all the patients who were on isotretinoin treatment. Treatment options and follow-up procedures for acne vulgaris may lead to the development of bacterial resistance and damage to flora. In particular, systemic tetracycline treatment leads to changes in flora of the nose and throat in patients with acne with an increased carriage of S. aureus. Therefore, careful attention should be paid to the duration of tetracycline treatment in order to not increase the risk of disturbance of microbial flora. © 2014 The International Society of Dermatology.

  12. Acne image analysis: lesion localization and classification

    Science.gov (United States)

    Abas, Fazly Salleh; Kaffenberger, Benjamin; Bikowski, Joseph; Gurcan, Metin N.

    2016-03-01

    Acne is a common skin condition present predominantly in the adolescent population, but may continue into adulthood. Scarring occurs commonly as a sequel to severe inflammatory acne. The presence of acne and resultant scars are more than cosmetic, with a significant potential to alter quality of life and even job prospects. The psychosocial effects of acne and scars can be disturbing and may be a risk factor for serious psychological concerns. Treatment efficacy is generally determined based on an invalidated gestalt by the physician and patient. However, the validated assessment of acne can be challenging and time consuming. Acne can be classified into several morphologies including closed comedones (whiteheads), open comedones (blackheads), papules, pustules, cysts (nodules) and scars. For a validated assessment, the different morphologies need to be counted independently, a method that is far too time consuming considering the limited time available for a consultation. However, it is practical to record and analyze images since dermatologists can validate the severity of acne within seconds after uploading an image. This paper covers the processes of region-ofinterest determination using entropy-based filtering and thresholding as well acne lesion feature extraction. Feature extraction methods using discrete wavelet frames and gray-level co-occurence matrix were presented and their effectiveness in separating the six major acne lesion classes were discussed. Several classifiers were used to test the extracted features. Correct classification accuracy as high as 85.5% was achieved using the binary classification tree with fourteen principle components used as descriptors. Further studies are underway to further improve the algorithm performance and validate it on a larger database.

  13. Underestimated clinical features of postadolescent acne.

    Science.gov (United States)

    Capitanio, Bruno; Sinagra, Jo Linda; Bordignon, Valentina; Cordiali Fei, Paola; Picardo, Mauro; Zouboulis, Christos C

    2010-11-01

    Postadolescent acne is usually described as an inflammatory, mild-to-moderate dermatosis, frequently involving the lower third of the face, the jawline, and the neck. However, we have also frequently observed a clinical form predominantly characterized by retention lesions (microcomedones and macrocomedones), with few inflammatory lesions (comedonal postadolescent acne [CPAA]), which appears significantly correlated with cigarette smoking. We sought to investigate the clinical features of postadolescent acne in a group of female patients affected by acne and its relationship with cigarette smoking. A total of 226 women with acne (25-50 years) attending our department were examined by a team of 3 dermatologists, to assess the age of onset of the disease, and the number, type, and distribution of acne lesions. In all, 192 of 226 patients (85.0%) were classified as having CPAA and 34 as having papulopustular postadolescent acne. A smoking habit was confirmed in 150 of 226 (66.3%). Remarkably, 72.9% of patients with CPAA were smokers as compared with only 29.4% of those with papulopustular postadolescent acne (P < .0001). Possible limitations are related to geographic area or to the prevalence of darker skin types (III and IV) (data about skin types have not been collected). Other possible aggravating factors (ie, stress and diet) have not been investigated. According to our results, CPAA appears as the most frequent clinical form of postadolescent acne and seems to be strictly correlated with cigarette smoking. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  14. Propionibacterium acnes endophthalmitis in Ahmed glaucoma valve.

    Science.gov (United States)

    Gutiérrez-Díaz, E; Montero-Rodríguez, M; Mencía-Gutiérrez, E; Fernández-González, M C; Pérez-Blázquez, E

    2001-01-01

    To report a case of Propionibacterium acnes endophthalmitis in a patient with an Ahmed glaucoma valve. A nine-year-old boy with bilateral congenital glaucoma, with an Ahmed glaucoma valve implanted in the left eye, had recurrent conjunctival dehiscence and endophthalmitis. Vitreous cultures demonstrated the presence of Propionibacterium acnes. This is the first reported case of Propionibacterium acnes endophthalmitis in an Ahmed glaucoma valve and the second one in a glaucoma drainage device. We strongly recommend using a patch graft to prevent and treat tube exposure. Conjunctival grafts may be useful to close the conjunctiva when there is marked scarring to prevent patch exposure and melting or extrusion.

  15. Complementary therapies for acne vulgaris

    Science.gov (United States)

    Cao, Huijuan; Yang, Guoyan; Wang, Yuyi; Liu, Jian Ping; Smith, Caroline A; Luo, Hui; Liu, Yueming

    2015-01-01

    Background Acne is a chronic skin disease characterised by inflamed spots and blackheads on the face, neck, back, and chest. Cysts and scarring can also occur, especially in more severe disease. People with acne often turn to complementary and alternative medicine (CAM), such as herbal medicine, acupuncture, and dietary modifications, because of their concerns about the adverse effects of conventional medicines. However, evidence for CAM therapies has not been systematically assessed. Objectives To assess the effects and safety of any complementary therapies in people with acne vulgaris. Search methods We searched the following databases from inception up to 22 January 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL; 2014, Issue 1), MEDLINE (from 1946), Embase (from 1974), PsycINFO (from 1806), AMED (from 1985), CINAHL (from 1981), Scopus (from 1966), and a number of other databases listed in the Methods section of the review. The Cochrane CAM Field Specialised Register was searched up to May 2014. We also searched five trials registers and checked the reference lists of articles for further references to relevant trials. Selection criteria We included parallel-group randomised controlled trials (or the first phase data of randomised cross-over trials) of any kind of CAM, compared with no treatment, placebo, or other active therapies, in people with a diagnosis of acne vulgaris. Data collection and analysis Three authors collected data from each included trial and evaluated the methodological quality independently. They resolved disagreements by discussion and, as needed, arbitration by another author. Main results We included 35 studies, with a total of 3227 participants. We evaluated the majority as having unclear risk of selection, attrition, reporting, detection, and other biases. Because of the clinical heterogeneity between trials and the incomplete data reporting, we could only include four

  16. Use of lipidomics to investigate sebum dysfunction in juvenile acne[S

    Science.gov (United States)

    Sinagra, Jo-Linda; Capitanio, Bruno

    2016-01-01

    Acne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity. Multiple factors centering on sebum secretion are implicated in acne pathogenesis. Despite the recognized role of sebum, its compositional complexity and limited analytical approaches have hampered investigation of alterations specifically associated with acne. To examine the profiles of lipid distribution in acne sebum, 61 adolescents (29 males and 32 females) were enrolled in this study. Seventeen subjects presented no apparent clinical signs of acne. The 44 affected individuals were clinically classified as mild (13 individuals), moderate (19 individuals), and severe (12 individuals) acne. Sebum was sampled from the forehead with SebutapeTM adhesive patches. Profiles of neutral lipids were acquired with rapid-resolution reversed-phase/HPLC-TOF/MS in positive ion mode. Univariate and multivariate statistical analyses led to the identification of lipid species with significantly different levels between healthy and acne sebum. The majority of differentiating lipid species were diacylglycerols (DGs), followed by fatty acyls, sterols, and prenols. Overall, the data indicated an association between the clinical grading of acne and sebaceous lipid fingerprints and highlighted DGs as more abundant in sebum from adolescents affected with acne. PMID:27127078

  17. Acne

    Science.gov (United States)

    ... free," "noncomedogenic," or "nonacnegenic." When you wash your face, take the time to remove all of your makeup. If you use hair sprays or gels, try to keep them away from your face because they can clog pores. If you have ...

  18. Acne

    Science.gov (United States)

    ... federal government website managed by the Office on Women's Health in the Office of the Assistant Secretary for Health at the U.S. Department of Health and Human Services . 200 Independence Avenue, S.W., Washington, DC 20201 1-800-994- ...

  19. Infantile acne treated with oral isotretinoin

    DEFF Research Database (Denmark)

    Miller, Iben Marie; Echeverría, Begoña; Torrelo, Antonio

    2013-01-01

    In contrast to adolescent acne, infantile acne (IA) is a rare condition with only a limited body of available literature. In this descriptive, retrospective study, we reviewed six cases from 2002 to 2010 treated with oral isotretinoin. The average age of onset was 6.16 months (range 0-21 mos......). Consistent with the previous, limited literature, we found predominantly boys are affected, a predilection for the cheeks, and a polymorphic inflammatory morphology. Two patients had a family history of acne. All cases were successfully and safely treated with oral isotretinoin. The suggested treatment...... of childhood acne is similar to that of adolescents (graded according to the severity of the skin disease and risk of scarring). Oral isotretinoin appears to be an effective and safe treatment for severe IA....

  20. Pregnancy Acne: What's the Best Treatment?

    Science.gov (United States)

    ... et al. Drug safety: Pregnancy ratings classifications and controversies. Clinics in Dermatology. 2016;34:401. Acne: Tips ... your agreement to the Terms and Conditions and Privacy Policy linked below. Terms and Conditions Privacy Policy ...

  1. A CLINICAL STUDY OF ACNE VULGARIS

    Directory of Open Access Journals (Sweden)

    Melathil Sadanandan Sadeep

    2017-11-01

    Full Text Available BACKGROUND Acne vulgaris is a highly prevalent chronic inflammatory disease of pilosebaceous unit affecting teenagers and young adults. Prognosis of acne is generally good, especially in mild acne. But, this disease reduces the self-esteem, their sense of identity and can severely compromise quality of life. All clinicians caring for children and adolescents should be familiar with this problem. Early diagnosis, proper treatment and timely counselling reduce the overall impact of disease to individuals. MATERIALS AND METHODS This is a prospective study conducted in the Department of Dermatology at Government Medical College, Kottayam, Kerala, in 200 patients who presented to the outpatient clinic with a clinical diagnosis of acne vulgaris who have not yet received any medical treatment for the disease and consented to participate in the study. RESULTS Male-to-female ratio of 1.43:1. 61.5% patients were in the 2nd decade. 4% were more than 30 years old. Duration of the disease at the time of presentation ranged from 3 weeks to 30 years. 42.5% complained of mild itching and 18.5% had burning sensation. 48.5% attribute exacerbation of disease after food intake. 72.5% acne patients had seborrhoea. Hirsutism and Acanthosis nigricans were present in 7.31% and 4.87% female patients, respectively. 50% with hirsutism and 25% with Acanthosis nigricans had polycystic ovarian disease and severe grades of acne. 25.6% females complained of premenstrual exacerbation of the disease. 26% of the patients showed exacerbation in summer. Smokers had severe grades of acne vulgaris compared to nonsmokers. Comedones were present in all and they were the predominant lesions in majority. Inflammatory papules were the 2nd most common lesions. Severe grades of acne were more common in patients with age ≥20 years. Severity of the disease increases with long duration of the disease. Relatively high incidence of post-acne scarring and post-inflammatory hyperpigmentation was

  2. [Light, laser and PDT therapy for acne].

    Science.gov (United States)

    Borelli, C; Merk, K; Plewig, G; Degitz, K

    2005-11-01

    In recent years, a number of studies have evaluated the treatment of acne using electromagnetic waves, such as lasers, photodynamic therapy, visible light or radio waves. While the efficacy of laser treatment is still uncertain, photodynamic therapy shows promising results, but with marked side-effects, as destruction of sebaceous glands. Treatment with blue light (405-420 nm wavelength) also appears effective and can be regarded as an treatment option for inflammatory acne.

  3. Light-based therapies in acne treatment

    Science.gov (United States)

    Pei, Susan; Inamadar, Arun C.; Adya, Keshavmurthy A.; Tsoukas, Maria M.

    2015-01-01

    The use of light and laser in the treatment of acne is increasing as these modalities are safe, effective, and associated with no or minimal complications when used appropriately. These light and laser sources are also being used in combination with pharmacological and/or physical measures to synergize their effects and optimize the therapeutic outcome. This review focuses on optical devices used in treating acne and serves to delineate the current application of various methods, including their utility and efficacy. PMID:26009707

  4. Pulse Clarithromycin Therapy In Severe ACNE Vulgaris

    Directory of Open Access Journals (Sweden)

    Rathi Sanjay K

    2002-01-01

    Full Text Available Three patients with severe acne vulgaris, not responding with long courses of doxycycline, minocycline and erythromycin were given oral clarithromycin in pulsed regimen. The patients were given 7 days course of clarithromycin 250mg twice daily, which was repeated after a gap of 10 days. Such 3 courses were given. The lesions responded significantly. No significant side effect was noted. Pulse clarithromycin therapy seems to be a good alternative and effective tool in the management of severe acne vulgaris.

  5. Imaging inflammatory acne: lesion detection and tracking

    Science.gov (United States)

    Cula, Gabriela O.; Bargo, Paulo R.; Kollias, Nikiforos

    2010-02-01

    It is known that effectiveness of acne treatment increases when the lesions are detected earlier, before they could progress into mature wound-like lesions, which lead to scarring and discoloration. However, little is known about the evolution of acne from early signs until after the lesion heals. In this work we computationally characterize the evolution of inflammatory acne lesions, based on analyzing cross-polarized images that document acne-prone facial skin over time. Taking skin images over time, and being able to follow skin features in these images present serious challenges, due to change in the appearance of skin, difficulty in repositioning the subject, involuntary movement such as breathing. A computational technique for automatic detection of lesions by separating the background normal skin from the acne lesions, based on fitting Gaussian distributions to the intensity histograms, is presented. In order to track and quantify the evolution of lesions, in terms of the degree of progress or regress, we designed a study to capture facial skin images from an acne-prone young individual, followed over the course of 3 different time points. Based on the behavior of the lesions between two consecutive time points, the automatically detected lesions are classified in four categories: new lesions, resolved lesions (i.e. lesions that disappear completely), lesions that are progressing, and lesions that are regressing (i.e. lesions in the process of healing). The classification our methods achieve correlates well with visual inspection of a trained human grader.

  6. Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Kilian, Mogens; Scholz, Christian F. P.; Lomholt, Hans B.

    2012-01-01

    Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer...... schemes were compared with reference to a phylogenetic tree based on 78 P. acnes genomes and their gene contents. Further support for a basically clonal population structure of P. acnes and a scenario of the global spread of epidemic clones of P. acnes was obtained. Compared to the Belfast scheme...

  7. Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Kilian, Mogens; Scholz, Christian; Lomholt, Hans B

    2011-01-01

    Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer...... with reference to a phylogenetic tree based on 78 P. acnes genomes and their gene contents. Further support for a basically clonal population structure of P. acnes and a scenario of global spread of epidemic clones of P. acnes was obtained. Compared with the Belfast scheme, the Aarhus MLST scheme (http...

  8. Acne e dieta: verdade ou mito? Acne and diet: truth or myth?

    Directory of Open Access Journals (Sweden)

    Adilson Costa

    2010-06-01

    Full Text Available Nos últimos 50 anos, foram publicados inúmeros estudos com a finalidade de comprovar se a dieta está relacionada à etiologia da acne. Embora existam estudos antigos, que são bem difundidos entre os dermatologistas e negam a associação entre acne e dieta, seu delineamento científico é pobre. Recentemente, novos artigos demonstraram evidências contrárias às publicações anteriores. Sendo assim, os autores realizaram esta revisão bibliográfica com o intuito de averiguar se a dieta influencia direta ou indiretamente um ou mais dos quatro pilares etiopatogênicos fundamentais da acne: (1 hiperproliferação dos queratinócitos basais, (2 aumento da produção sebácea, (3 colonização pelo Propionibacterium acnes e (4 inflamação.Numerous studies were published over the last 50 years to investigate whether diet is associated with the etiology of acne. Although older studies well known by dermatologists that refute the association between acne and diet exist, their scientific foundation is weak. New articles have recently brought to light evidence contrary to previous findings. Therefore, we would like to investigate whether diet, directly or indirectly, influences one or more of the four fundamental etiopathogenic pillars of acne: (1 hyperproliferation of basal keratinocytes, (2 increase of sebaceous production, (3 colonization by Propionibacterium acnes, and (4 inflammation.

  9. Dental cavities

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001055.htm Dental cavities To use the sharing features on this page, please enable JavaScript. Dental cavities are holes (or structural damage) in the ...

  10. 120 MW, 800 MHz Magnicon for a Future Muon Collider

    International Nuclear Information System (INIS)

    Jay L. Hirshfield

    2005-01-01

    Development of a pulsed magnicon at 800 MHz was carried out for the muon collider application, based on experience with similar amplifiers in the frequency range between 915 MHz and 34.3 GHz. Numerical simulations using proven computer codes were employed for the conceptual design, while established design technologies were incorporated into the engineering design. A cohesive design for the 800 MHz magnicon amplifier was carried out, including design of a 200 MW diode electron gun, design of the magnet system, optimization of beam dynamics including space charge effects in the transient and steady-state regimes, design of the drive, gain, and output cavities including an rf choke in the beam exit aperture, analysis of parasitic oscillations and design means to eliminate them, and design of the beam collector capable of 20 kW average power operation

  11. Nanoparticle Stabilized Liposomes for Acne Therapy

    Science.gov (United States)

    Fu, Victoria

    Acne vulgaris is a common skin disease that affects over 40 million people in the United States alone. The main cause of acne vulgaris is Propionibacterium acnes (P. acnes), resides deep in the pores and follicles of the skin in order to feed on oil produced by the sebaceous glands. The liposome is a lipid based nanoparticle with numerous advantages over free drug molecules as an acne treatment alternative. Bare liposomes loaded with lauric acid (LipoLA) were found to show strong antimicrobial activity against P. acnes while generating minimal toxicity. However, the platform is limited by the spontaneous tendency of liposomes to fuse with each other. Attaching nanoparticles to the surface of liposomes can overcome this challenge by providing steric repulsion and reduce surface tension. Thus, carboxyl-functionalized gold nanoparticles (AuC) were attached to the surface of liposomes (AuC-liposomes) loaded with doxycycline, a general tetracycline antibiotic. These particles were found to have a diameter of 120 nm and a zeta potential of 20.0 mV. Both fluorescent and antimicrobial studies demonstrated that based on electrostatic interaction, negatively charged AuC attached to the liposome's positively charged surface and stabilized liposomes in a neutral pH environment (pH = 7.4). Upon entering the skin's acidic environment (pH = 4), AuC detached from the liposome's surface and liposomes could fuse with P. acnes residing in the pores. Furthermore, toxicity studies showed that AuC-liposomes did not induce any significant toxicity, while two of the leading over-the-counter therapies, benzoyl peroxide and salicylic acid, generated substantial skin irritation.

  12. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris.

    Science.gov (United States)

    Rostami Mogaddam, Majid; Safavi Ardabili, Nastaran; Maleki, Nasrollah; Soflaee, Maedeh

    2014-01-01

    Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P = 0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

  13. Development of Acne therapeutic hydrogel patches by radiation technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Younmook; Nho, Youngchang; Gwon, Huijeong; Park, Jongseok; Kim, Jinkyu; Kim, Yongsoo

    2012-04-15

    In this project, hydrogel patches containing herbal extracts mixture were developed by radiation technology for acne treatment. Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, is the cause of inflammatory acne. To find novel mediation for inflammation of P. acnes, we confirmed the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The water extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thumb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were mixed into biocompatible polymers and irradiated by using gamma-ray to prepare hydrogels. The hydrogels containing herbal extracts mixture initiated to decrease the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-{alpha}, IL-8, IL-1{beta} and IL-6, in experiment with human monocytic THP-1 cells treated with heat-killed P. acnes at 1 mg/ml of mixture concentration.

  14. Development of Acne therapeutic hydrogel patches by radiation technology

    International Nuclear Information System (INIS)

    Lim, Younmook; Nho, Youngchang; Gwon, Huijeong; Park, Jongseok; Kim, Jinkyu; Kim, Yongsoo

    2012-04-01

    In this project, hydrogel patches containing herbal extracts mixture were developed by radiation technology for acne treatment. Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, is the cause of inflammatory acne. To find novel mediation for inflammation of P. acnes, we confirmed the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The water extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thumb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were mixed into biocompatible polymers and irradiated by using gamma-ray to prepare hydrogels. The hydrogels containing herbal extracts mixture initiated to decrease the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-α, IL-8, IL-1β and IL-6, in experiment with human monocytic THP-1 cells treated with heat-killed P. acnes at 1 mg/ml of mixture concentration

  15. Evaluation of acne quality of life, loneliness and life satisfaction levels in adolescents with acne vulgaris

    Directory of Open Access Journals (Sweden)

    İjlal Erturan

    2014-12-01

    Full Text Available Background and Design: Acne vulgaris is a dermatological disorder mainly seen in adolescents. Psychiatric morbidity has been reported in these patients. The aim of the present study was to investigate the quality of life, loneliness and life satisfaction levels in adolescents with acne vulgaris. Materials and Methods: A total of 264 adolescents with acne and 250 controls were included in the study. Acne severity was determined by the Global Acne Grading System (GAGS. Acne Quality of Life Scale (AQOL; developed by Gupta et al., UCLA Loneliness scale (ULS; developed by Russell, Peplau & Ferguson (1978, and the Life Satisfaction Scale (LSS; developed by Diener et al. were used to asses life quality, loneliness and life satisfaction levels, respectively in adolescents with acne and in controls. Results: The mean AQOL and the mean ULS scores were significantly higher in patients (13.67±4.75 vs 11.14±2.94, p<0.001 and 32.15±8.46 vs 30.52±8.70,p=0.031, respectively. The mean LSS score was significantly lower in acne patients (21.82±6.40 than in controls (23.04±6.45, p=0.033. There was a statistically significant difference in the mean LSS scores between the mild, moderate and severe acne patients (22.15±6.32, 21.61±6.20, 16.00±7.26, respectively; Kruskal Wallis Test p=0.036. While there was no significant difference in the mean ULS and LSS scores between the genders. The mean ALQI score was significantly higher in males than in females (p=0.004. Conclusion: Our results indicated that acne quality of life and life satisfaction levels were significantly reduced while loneliness levels were significantly increased in adolescents with acne compared to controls. Our study is important in terms of being the first study investigating the loneliness and life satisfaction levels in acne patients and the relationship between these parameters and severity of acne.

  16. Environmental pollution and acne: Chloracne

    Science.gov (United States)

    Zouboulis, Christos C; Xia, Longqing

    2009-01-01

    Environmental pollutants can result in a variant of acne called ‘chloracne’. Chloracne is caused by systemic exposure to certain halogenated aromatic hydrocarbons ‘chloracnegens’, and is considered to be one of the most sensitive indicators of systemic poisoning by these compounds. Dioxin is the most potent environmental chloracnegen. Most cases of chloracne have resulted from occupational and non-occupational exposures, non-occupational chloracne mainly resulted from contaminated industrial wastes and contaminated food products. Non-inflammatory comedones and straw-colored cysts are the primary clinical manifestation of chloracne. Increasing of cysts in number is a signal of aggravation of chloracne. Generalized lesions can appear on the face, neck, trunk, exterimities, genitalia, axillary and other areas. Course of chloracne is chronic. Severity of chloracne is related to dosage of exposed chloracnegens, chloracnegenic potency and individual susceptibility. Histopathology of chloracne is characterized mainly by hyperplasia of epidermal cell, while follicular and sebaceous gland are taken placed by keratinized epidermal cell. The pathogenesis of chloracne maybe related to the imbalance of epidermal stem cell. Chloracne appears to be resistant to all tested forms of treatment. The only way to control chloracne is to prevent exposure to chloracnegens. PMID:20436879

  17. Mechanical design and fabrication of power feed cavity test setup

    International Nuclear Information System (INIS)

    Ghodke, S.R.; Dhavle, A.S.; Sharma, Vijay; Sarkar, Shreya; Kumar, Mahendra; Nayak, Susanta; Barnwal, Rajesh; Jayaprakash, D.; Mondal, J.; Nimje, V.T.; Mittal, K.C.; Gantayet, L.M.

    2013-01-01

    Power feed cavity set up consists of nine number of accelerating cavity and eight numbers of coupling cavity for testing of power feed cavity with coupling flange for 2856 MHz S band standing wave coupled cavity linac. When we are assembling the cavity and applying the pressure, its resonance frequency changes with applied pressure/load. After some critical pressure/load frequency change becomes negligible or zero. This set up will be used to find out assembly performance of power feed cavity and its coupler. Top four cavity or eight half cells as well as bottom four cavity or eight half cells will be brazed separately. Power feed cavity will be sandwiched between this two brazed cavity assemblies. This paper discuss about linear motion bush, linear motion rod, load cell, hydraulic actuator, power pack, stepper motor PLC control, jig boring, alignment, tolerances and assembly procedure for this test setup. (author)

  18. STRUCTURAL ANALYSIS OF SUPERCONDUCTING ACCELERATOR CAVITIES

    International Nuclear Information System (INIS)

    Schrage, D.

    2000-01-01

    The static and dynamic structural behavior of superconducting cavities for various projects was determined by finite element structural analysis. The β = 0.61 cavity shape for the Neutron Science Project was studied in detail and found to meet all design requirements if fabricated from five millimeter thick material with a single annular stiffener. This 600 MHz cavity will have a Lorentz coefficient of minus1.8 Hz/(Mv/meter) 2 and a lowest structural resonance of more than 100 Hz. Cavities at β = 0.48, 0.61, and 0.77 were analyzed for a Neutron Science Project concept which would incorporate 7-cell cavities. The medium and high beta cavities were found to meet all criteria but it was not possible to generate a β = 0.48 cavity with a Lorentz coefficient of less than minus3 Hz/(Mv/meter) 2

  19. The Association between Cigarette Smoking and Acne Intensity

    Directory of Open Access Journals (Sweden)

    Taheri Ramin

    2009-06-01

    Full Text Available Background: Acne vulgaris is a common chronic inflammatory disease of pilosebaceous unit. Different factors have been suggested to influence acne including diet, menstruation and occupation. The role of some of these factors on acne intensity is confirmed. The affect of Cigarette smoking on acne intensity has been suggested. In this research, we evaluated the association between cigarette smoking and the acne intensity.Materials and Methods: This cross-sectional study was performed on 278 smoker and 277non smoker males referred to dermatology clinics of Semnan during 2006-2007. The dermatologists interviewing the patients completed questionnaires based on clinical diagnosis and intensity of acne. Data analysis was performed using t-test, Mann-Whitney, Chi-square and Spearman coefficient tests. P-value less than 0.05 were considered significant. Results: Severe acne was observed in 16.6% of non-smokers and 22.7% of smokers. Distribution of acne intensity in both groups was significant (P=0.023. Association between duration of cigarette smoking and acne intensity was significant too (P<0.001. The association between dosage of cigarette smoking and acne intensity was also significant (P<0.001.Conclusion: Significant association between cigarette smoking and acne intensity showed that smoking withdrawal is helpful for reducing the acne intensity

  20. Antimicrobial effects of Indian medicinal plants against acne ...

    African Journals Online (AJOL)

    Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Indian medicinal plants against these etiologic agents of acne vulgaris. Ethanolic extracts of Hemidesmus ...

  1. 21 CFR 333.310 - Acne active ingredients.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Acne active ingredients. 333.310 Section 333.310... FOR HUMAN USE TOPICAL ANTIMICROBIAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Topical Acne Drug Products § 333.310 Acne active ingredients. The active ingredient of the product consists of any of the...

  2. Tuner Design for PEFP Superconducting RF Cavities

    International Nuclear Information System (INIS)

    Tang, Yazhe; An, Sun; Zhang, Liping; Cho, Yong Sub

    2009-01-01

    A superconducting radio frequency (SRF) cavity will be used to accelerate a proton beam after 100 MeV at 700 MHz in a linac of the Proton Engineering Frontier Project (PEFP) and its extended project. In order to control the SRF cavity's operating frequency at a low temperature, a new tuner has been developed for the PEFP SRF cavities. Each PEFP superconducting RF cavity has one tuner to match the cavity resonance frequency with the desired accelerator operating frequency; or to detune a cavity frequency a few bandwidths away from a resonance, so that the beam will not excite the fundamental mode, when the cavity is not being used for an acceleration. The PEFP cavity tuning is achieved by varying the total length of the cavity. The length of the cavity is controlled differentially by tuner acting with respect to the cavity body. The PEFP tuner is attached to the helium vessel and drives the cavity Field Probe (FP) side to change the frequency of the cavity

  3. Fraxelated radiofrequency device for acne scars

    Science.gov (United States)

    Rao, Babar K.; Khokher, Sairah

    2012-09-01

    Acne scars can be improved with various treatments such as topical creams, chemical peels, dermal fillers, microdermabrasion, laser, and radiofrequency devices. Some of these treatments especially lasers and deep chemical peels can have significant side effects such as post inflammatory hyperpigmentation in darker skin types. Fraxelated RF Laser devices have been reported to have lower incidence of side effects in all skin phototypes. Nine patients between ages 18 and 35 of various skin phototypes were selected from a private practice and treated with a RF fraxelated device (E-matrix) for acne scars. Outcomes were measured by physician observation, subjective feedback received by patients, and comparison of before and after photographs. In this small group of patients with various skin phototypes, fraxelated radiofrequency device improved acne scars with minimal side effects and downtime.

  4. Progress on SCRF cavity manufacturing activities at RRCAT

    International Nuclear Information System (INIS)

    Puntambekar, A.; Dwivedi, J.; Mundra, G.; Srivastava, P.; Joshi, S.C.; Gupta, P.D.

    2015-01-01

    The work on development of SCRF cavities and associated technologies is ongoing at RRCAT to support its upcoming projects involving SC LINAC. RRCAT is also a member of Indian Institution Fermilab Collaboration (IIFC) working on development of SCRF cavities and associated technologies. Subsequent to 1.3 GHz single cell SCRF cavities, a 650 MHz single cell, a 1.3 GHz five cell and a 1.3 GHz nine cell SCRF cavities have been fabricated. These were tested for their mechanical, vacuum and RF qualifications at RRCAT for pre qualifications. The 1.3 GHz five cell SCRF cavity and 650 MHz single cell SCRF cavity has been processed and successfully tested at Fermi lab under IIFC. The 1.3 GHz five-cell cavity has achieved E acc of 20.3 MV/m at 2 K and 42 MV/m at 1.5-1.7 K with Q o of 2 x 10 10 . The 650 MHz single cell cavity has achieved the E acc > 19.3 MV/m with Q> 4x 10 10 at 2K. A 15 kW Electron Beam Welding (EBW) Machine has also been installed and commissioned at RRCAT as part of special infrastructure for development of SCRF cavities. One each 1.3 GHz and 650 MHz single cell SCRF cavities have also been fabricated using this EBW facility. Present focus of work is towards development of 650 MHz (β=0.92) multi-cell SCRF cavities. This paper will present the various technology development efforts on SCRF cavity fabrication, cavity test results and future plans. (author)

  5. Design Considerations for the LHC 200 MHz RF System

    CERN Document Server

    Boussard, Daniel; Kindermann, H P; Linnecar, Trevor Paul R; Marque, S; Tückmantel, Joachim

    2000-01-01

    The longitudinal beam transfer from the SPS into the LHC 400 MHz buckets will not be free of losses without a lower frequency capture system and a fast longitudinal damping system in LHC. We present a complete study of a combined system using four identical copper cavities at 200 MHz delivering 3 MV total CW voltage and having still enough bandwidth to achieve fast longitudinal damping. The shape of a cavity was designed according to the accelerating mode performance, its tuning and the higher order mode spectrum with respect to the LHC beam lines and their possible attenuation. The possibility to park the cavities during coast was included. The local heat load and the corresponding cooling water distribution as well as deformations were studied and techniques to build the cavity with all ports at low cost are proposed. The parameters of the RF generators, couplers and detuning are determined. Simulations of the total LHC RF system incorporating real delays, generator bandwidth and the control loops confirm t...

  6. Combination therapy of acne in women: searching for optimum solutions

    Directory of Open Access Journals (Sweden)

    M. V. Goryachkina

    2014-01-01

    Full Text Available Current data on the acne pathogenesis are given. According to the authors, dermatosis is becoming more prevalent among women of mature age. Issues related to the clinical picture, effect of exogenous and endogenous factors on the course of acne, and psychosocial characteristics of delayed acne manifestations in women are described in detail. The essential role of medical and cosmetic products for the complex therapy of acne is discussed. The authors describe their own experience of treating delayed acne using the Hyseac line of medical and cosmetic products in a combination with microdermabrasion and no-needle mesotherapy using the vitaPeel/vital О2 device.

  7. Acne Scarring—Pathogenesis, Evaluation, and Treatment Options

    Science.gov (United States)

    Connolly, Deirdre; Vu, Ha Linh; Mariwalla, Kavita

    2017-01-01

    Acne vulgaris is a ubiquitous problem affecting 80 percent of people ages 11 to 30 years, with many patients experiencing some degree of scarring. This review focuses on atrophic scars, the most common type of acne scar. We briefly address the cellular sequelae that lead to scar formation and the initial evaluation of patients with acne scars. We then discuss an algorithmic approach to the treatment of acne scarring based on the classification of scars into erythematous and atrophic types. Lastly, we discuss the future treatment of acne scars and ongoing clinical trials. PMID:29344322

  8. Parallel bias vs perpendicular bias of a ferrite tuned cavity for the TRIUMF KAON Factory booster ring

    International Nuclear Information System (INIS)

    Poirier, R.L.; Enegren, T.A.

    1988-06-01

    The RF cavity reference design for the KAON Factory booster ring is a double gap drift-tube cavity with parallel biased ferrite tuners to vary the frequency from 46 MHz to 62 MHz. LAMPF has developed a single gap cavity with perpendicularly biased ferrite to vary the frequency from 50 MHz to 60 MHz. Measurements on the LAMPF cavity have indicated that their frequency range could be extended to cover our requirements while still maintaining a reasonable magnetic Q. The analysis and comparison of the RF circuit and the AC magnetizing circuit for both designs are reported. (Author) (14 refs., 6 figs.)

  9. Acne is not Associated with yet Uncultured Bacteria

    DEFF Research Database (Denmark)

    Bek-Thomsen, Malene; Lomholt, Hans Bredsted; Kilian, Mogens

    2008-01-01

    Current clinical and microbiological information on acne fail to demonstrate a clear association between particular species, including Propionibacterium acnes, and disease, and the disease continues to be a considerable problem. To test if acne is associated with hitherto uncultured bacteria...... residing in diseased skin follicles, sequencing and phylogenetic analysis of approximately 5,700 amplified and cloned 16S rRNA genes were used to determine the microbial diversity in follicles from acne patients and healthy individuals and from superficial skin of acne patients. Follicles from healthy skin...... were exclusively colonized by P. acnes, whereas the follicular microbiota of acne patients, in addition, included S. epidermidis and minor proportions of other species. In comparison, samples from superficial skin showed a complex microbiota with 12 to 16 bacterial species represented. The study...

  10. Do generalists and specialists agree on descriptive acne morphology?

    DEFF Research Database (Denmark)

    Yazdanyar, S; Bryld, L E; Heidenheim, M

    2013-01-01

    BACKGROUND: Acne is a common skin disease, which is treated by many different specialities. Clinical guidelines for treatment are based on the recognition of acne morphology. The assessment of acne morphology is therefore an important element of the proper diagnosis and treatment of acne. OBJECTIVE......: To evaluate the level of congruence in the assessment of acne morphology in General Practitioners (GPs) and Dermatologists compared to the assessment of an expert. METHODS: The study was conducted during 2008-2009. Randomly selected GP and Dermatologists Practitioners, (DPs) from Denmark were invited...... in the distribution of answers. CONCLUSION: GPs described acne morphology recognized clinical hallmarks of severity in acne less well than dermatologists and were far less consistent....

  11. Significance of diet in treated and untreated acne vulgaris

    Science.gov (United States)

    Szmurło, Agnieszka; Sińska, Beata

    2016-01-01

    The relationship between diet and acne is highly controversial. Several studies during the last decade have led dermatologists to reflect on a potential link between diet and acne. This article presents the latest findings on a potential impact that diet can have on pathogenesis of acne vulgaris. The association between diet and acne can no longer be dismissed. Compelling evidence shows that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acne and the roles of omega-3 fatty acids, dietary fiber, antioxidants, vitamin A, zinc and iodine remain to be elucidated. The question of what the impact of diet is on the course of acne vulgaris still remains unclear. PMID:27279815

  12. HOM power in FCC-ee cavities

    CERN Document Server

    Karpov, Ivan; Chapochnikova, Elena

    2018-01-01

    This Note summarizes the results of the power loss calculations for FCC-ee machines with 400.79 MHz cavity options. The requirements for the single-cell cavity design and for the operation with beam are obtained from the results for the high-current FCC-ee machine (Z). For other machines the power loss is sufficiently low and can be absorbed and extracted by foreseen HOM couplers.

  13. Is acne a sign of androgen excess disorder or not?

    Science.gov (United States)

    Uysal, Gulsum; Sahin, Yılmaz; Unluhizarci, Kursad; Ferahbas, Ayten; Uludag, Semih Zeki; Aygen, Ercan; Kelestimur, Fahrettin

    2017-04-01

    Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne. The women were assigned as polycystic ovary syndrome (PCOS), idiopathic hirsutism (IH), idiopathic hyperandrogenemia (IHA). Women with acne associated with any of the androgen excess disorders mentioned above were named as hyperandrogenemia associated acne (HAA). Women with acne but without hirsutism and hyperandrogenemia and having ovulatory cycles were named as "isolated acne". Serum luteinizing hormone, follicle stimulating hormone, estradiol, progesterone, 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate (DHEAS), androstenedione, total testosterone and lipid levels were measured. Acne score was similar between the women with isolated acne and HAA. The most common cause for acne was PCOS and only 28% of the women had isolated acne. 114 (55%) women had at least one raised serum androgen level. In this study, 72% of acneic women had clinical and/or biochemical hyperandrogenemia. In contrast to the suggestion of ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group, our data indicate that the presence of androgen excess disorders should be evaluated in women presenting with acne. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. [Acne vulgaris: morphologic, endocrinologic and psychosomatic aspects].

    Science.gov (United States)

    Welp, K; Gieler, U

    1990-12-01

    25 male patients suffering from acne vulgaris were examined by means of endocrinological, morphological, and 5 psychometric procedures in order to check the correlations and interactions between the psychological and dermatological aspects of the disease. In comparison with a control group, the acne patients did not show any striking endocrinological abnormalities; we found no correlation between the extensiveness of the lesions and the level of DHEA sulphate. All the psychological tests yielded results deviating from those achieved by the representative controls, but they were comparable with those of other patients suffering from psychosomatic diseases. The individual feeling of being "disfigured" found its expression in self-consciousness, lack of trust in his/her own body, as well as the clinically relevant difference between his/her conception of self and the ideal of self. During times of enhanced psychosocial strains subjectively assumed by the patients, the lesions increased and the patients were disturbed in social interaction and communication. Surprisingly, we did not find any correlation between the clinical status and significant psychometric findings. Our results show that in acne vulgaris, the individual experience of wanting physical attractiveness, associated with a predominantly neurotic depressive personal structure, may play a central part in a disturbed process of interaction with the environment and suggest the influence of psychic factors in the pathogenesis of acne vulgaris.

  15. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells.

    Directory of Open Access Journals (Sweden)

    Maria Juszkiewicz-Borowiec

    2009-01-01

    Full Text Available Propionibacterium acnes (P. acnes has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response. The exposure of dendritic cells (DCs to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature DCs into antigen-presenting mature DCs. The aim of the study was to evaluate the capability of P. acnes to induce the maturation of DCs. We stimulated monocyte derived dendritic cells (Mo-DCs from acne patients with various concetrations of heat-killed P. acnes (10(6-10(8 bacteria/ml cultured from acne lesions. The results showed an increase in CD80+/CD86+/DR+ and CD83+/CD1a+/DR+ cells percentage depending on the concetration of P. acnes. The expression of CD83 and CD80 (shown as the mean fluorescence intensity - MFI increased with higher concetrations of P. acnes. There were also significant correlations between MFI of CD83, CD80, CD86 and concetration of P. acnes. The study showed that P. acnes in the concetration of 10(8 bacteria/ml is most effective in the induction of Mo-DCs maturation. Futher studies concerning the influence on the function of T cells are needed.

  16. 27.12 MHz Radiofrequency Ablation for Benign Cutaneous Lesions

    Directory of Open Access Journals (Sweden)

    Dong Hyun Kim

    2016-01-01

    Full Text Available As surgical and/or ablative modalities, radiofrequency (RF has been known to produce good clinical outcomes in dermatology. Recently, 27.12 MHz RF has been introduced and has several advantages over conventional 4 or 6 MHz in terms of the precise ablation and lesser pain perception. We aimed to evaluate the clinical efficacy and safety of 27.12 MHz RF for the treatment of benign cutaneous lesions. Twenty female patient subjects were enrolled. Digital photography and a USB microscope camera were used to monitor the clinical results before one session of treatment with 27.12 MHz RF and after 1 and 3 weeks. Treated lesions included telangiectasias, cherry and spider angiomas, skin tags, seborrheic keratoses, lentigo, milium, dilated pore, acne, piercing hole, and one case of neurofibroma. For vascular lesions, clinical results were excellent for 33.3%, good for 44.4%, moderate for 11.1%, and poor for 11.1%. For nonvascular lesions (epidermal lesions and other benign cutaneous lesions, clinical results were excellent for 48.3%, good for 45.2%, moderate for 3.2%, and poor for 3.2%. No serious adverse events were observed. Mild adverse events reported were slight erythema, scale, and crust. The 27.12 MHz RF treatment of benign vascular and nonvascular lesions appears safe and effective after 3 weeks of follow-up.

  17. Multiple Activities of Punica granatum Linne against Acne Vulgaris.

    Science.gov (United States)

    Lee, Chia-Jung; Chen, Lih-Geeng; Liang, Wen-Li; Wang, Ching-Chiung

    2017-01-12

    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes ( P . acnes ) and Staphylococcus aureus , and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P . acnes -induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin ( 1 ), punicalin ( 2 ), strictinin A ( 3 ), and granatin B ( 4 ), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1 , 3 , and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E₂ production in heat-killed P . acnes -treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin ( 1 ), the most effective component in PG-E, can be employed as a quality control marker.

  18. accelerating cavity

    CERN Multimedia

    On the inside of the cavity there is a layer of niobium. Operating at 4.2 degrees above absolute zero, the niobium is superconducting and carries an accelerating field of 6 million volts per metre with negligible losses. Each cavity has a surface of 6 m2. The niobium layer is only 1.2 microns thick, ten times thinner than a hair. Such a large area had never been coated to such a high accuracy. A speck of dust could ruin the performance of the whole cavity so the work had to be done in an extremely clean environment.

  19. Deflecting cavity for beam diagnostics at Cornell ERL injector

    International Nuclear Information System (INIS)

    Belomestnykh, Sergey; Bazarov, Ivan; Shemelin, Valery; Sikora, John; Smolenski, Karl; Veshcherevich, Vadim

    2010-01-01

    A single-cell, 1300-MHz, TM110-like mode vertically deflecting cavity is designed and built for beam slice emittance measurements, and to study the temporal response of negative electron affinity photocathodes in the ERL injector at Cornell University. We describe the cavity shape optimization procedure, RF and mechanical design, its performance with beam.

  20. Electromagnetic Design of a Radiofrequency Cavity

    Science.gov (United States)

    Montoya Soto, G. R.; Duarte Galvan, Carlos; Monzon, Ildefonso Leon; Podesta Lerma, Pedro Luis manuel; Valerio-Lizarraga, C. A.

    2017-10-01

    Electromagnetic and mechanical studies have been performed with the aim of build a RF cavity in the S-Band (2998 MHz), the design takes into consideration the relativistic change in the electron velocity through the acceleration cavity. Four cavity cases were considered at different input energies, 50 KeV, 100 KeV, 150 KeV, with output energies of 350 KeV, the designs show good acceleration efficiency and beam coherence comparable to the one created in the cathode.

  1. The epidemiology of adolescent acne in North East China.

    Science.gov (United States)

    Wei, B; Pang, Y; Zhu, H; Qu, L; Xiao, T; Wei, H-C; Chen, H-D; He, C-D

    2010-08-01

    Adolescent acne impacts self-esteem and quality of life in adolescents and its aetiology is not fully clarified. The aim of this study was to describe the epidemiological features of adolescent acne in North East China and determine the impact of genetic and environmental factors on the pathogenesis of acne. Data were collected from 5696 undergraduates (2920 patients and 2776 controls) using questionnaire. The survey data were analysed using spss version 13.0 and heritability of adolescent acne was calculated using Falconer's method. Total prevalence of adolescent acne was 51.30% (52.74% in males, 49.65% in females). The difference between genders was statistically significant (P skin and mixed type skin. Protective factors include (presented in descending order of occurrence) dry skin, neutral skin, frequent fruit consumption and computer access time skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents.

  2. Autoinflammatory syndromes associated with hidradenitis suppurativa and/or acne

    DEFF Research Database (Denmark)

    Vinkel, Caroline; Thomsen, Simon F.

    2017-01-01

    Autoinflammatory syndromes associated with hidradenitis suppurativa (HS) and/or acne are rare but potentially debilitating disorders if not diagnosed and treated correctly. They share a common pathogenesis involving a dysregulated innate immune system with abnormal interleukin (IL)-1 signaling...... leading to sterile neutrophilic inflammation. The clinical features are recurrent episodes of fever, painful arthritis, and skin lesions consistent with HS, acne, and pyoderma gangrenosum (PG) accompanied by elevated systemic inflammatory markers in blood. So far, several clinically different syndromes...... have been reported in the literature including pyoderma gangrenosum, acne, and pyogenic arthritis (PAPA), pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, and spondyloarthritis (PASS), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis...

  3. Energy-Based Devices in Treatment of Acne Vulgaris.

    Science.gov (United States)

    Handler, Marc Z; Bloom, Bradley S; Goldberg, David J

    2016-05-01

    Acne vulgaris is a chronic dermatologic complaint with a multifactorial cause. Traditionally, antibiotics and retinoids have been used to manage the condition; patient compliance has been an ongoing issue. A variety of energy-based devices have been reported to be effective in the treatment of acne vulgaris. To review and summarize the current literature specific to treatment of acne vulgaris with energy-based devices. A review of the current literature of energy-based devices used for the treatment of acne vulgaris. Although limited randomized controlled trials for the treatment of acne have been performed, significant clinical improvement of acne vulgaris, especially of inflammatory lesions, has been demonstrated with a variety of energy-based devices. Newer approaches may lead to even better results.

  4. A Honey Trap for the Treatment of Acne: Manipulating the Follicular Microenvironment to Control Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    E. Anne Eady

    2013-01-01

    Full Text Available Today, as 40 years ago, we still rely on a limited number of antibiotics and benzoyl peroxide to treat inflammatory acne. An alternative way of suppressing the growth of Propionibacterium acnes is to target the environment in which it thrives. We conjecture that P. acnes colonises a relatively “extreme” habitat especially in relation to the availability of water and possibly related factors such as ionic strength and osmolarity. We hypothesise that the limiting “nutrient” within pilosebaceous follicles is water since native sebum as secreted by the sebaceous gland contains none. An aqueous component must be available within colonised follicles, and water may be a major factor determining which follicles can sustain microbial populations. One way of preventing microbial growth is to reduce the water activity ( of this component with a biocompatible solute of very high water solubility. For the method to work effectively, the solute must be small, easily diffusible, and minimally soluble in sebaceous lipids. Xylose and sucrose, which fulfil these criteria, are nonfermentable by P. acnes and have been used to reduce water activity and hence bacterial colonisation of wounds. A new follicularly targeted topical treatment for acne based on this approach should be well tolerated and highly effective.

  5. Early prototype of a superconducting RF cavity for LEP

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    As early as 1979, before LEP became an approved project, studies were located in the ISR Division. Although Cu-cavities were foreseen, certainly for the 1st energy-stage, superconducting cavities were explored as a possible alternative for the 2nd energy-stage. This began with very basic studies of manufacture and properties of Nb-cavities. This one, held by Mr.Girel, was made from bulk Nb-sheet, 2.5 mm thick. It was dimensioned for tests at 500 MHz (LEP accelerating RF was 352.2 MHz). See also 8004204, 8007354, 8209255, 8210054, 8312339.

  6. POTENSI KEFIR SEBAGAI ANTIBAKTERI Propionibacterium acnes

    OpenAIRE

    ., Michael

    2015-01-01

    Jerawat merupakan suatu keadaan dimana pori-pori kulit tersumbat oleh kotoran dan adanya bakteri Propionibacterium acnes yang berkembang biak di daerah sumbatan tersebut. Di Indonesia, masyarakat mulai melirik suatu produk minuman yang dipercaya secara empiris dapat mengatasi masalah jerawat, yaitu produk minuman fermentasi kefir. Kefir merupakan produk fermentasi yang memiliki cita rasa asam dan sedikit beralkohol. Kefir dapat difermentasi dengan air maupun dengan susu. Kan...

  7. Role of insulin resistance and diet in acne

    Directory of Open Access Journals (Sweden)

    Rashmi Kumari

    2013-01-01

    Full Text Available There is increasing evidence in support of the interplay of growth hormone (GH, insulin, and insulin-like growth factor-1 (IGF-1 signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.

  8. Inversion of the OH 1720-MHz line

    International Nuclear Information System (INIS)

    Elitzur, M.

    1975-01-01

    It is shown that the OH 1720-MHz line can be strongly inverted by collisions which excite the rotation states. It is also argued that radiative pumps (of any wave length) can invert strongly only the 1612-MHz line. (author)

  9. LAMPF 201.25-MHz linac field distribution

    International Nuclear Information System (INIS)

    Jameson, R.A.; Halbig, J.K.

    1978-01-01

    Returning of the 201.25-MHz accelerator structure field distributions after the 1975 shutdown is described, and final data are given for use in beam dynamics studies. Several improvements made in procedures included a different method for stopband closure check and a positive method for postcoupler clamping. To obtain accurate results for the first tank a rigorous data reduction technique that included the removal of a ''signature'' due to the bead-pull string itself was used. Other special studies are reported, including the effects of vacuum, bead size, slug tuners, and a bead-pull method for measuring the cavity quality factor Q

  10. BNL 56 MHz HOM Damper Prototype Fabrication at JLab

    Energy Technology Data Exchange (ETDEWEB)

    Huque, Naeem A. [Jefferson Lab., Newport News, VA (United States); Daly, Edward F. [Jefferson Lab., Newport News, VA (United States); Clemens, William A. [Jefferson Lab., Newport News, VA (United States); McIntyre, Gary T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wu, Qiong [Brookhaven National Lab. (BNL), Upton, NY (United States); Seberg, Scott [Brookhaven National Lab. (BNL), Upton, NY (United States); Bellavia, Steve [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-01

    A prototype Higher-Order Mode (HOM) Damper was fabricated at JLab for the Relativistic Heavy-Ion Collider's (RHIC) 56 MHz cavity at Brookhaven National Laboratory (BNL). Primarily constructed from high RRR Niobium and Sapphire, the coaxial damper presented significant challenges in electron-beam welding (EBW), brazing and machining via acid etching. The results of the prototype operation brought about changes in the damper design, due to overheating braze alloys and possible multi-pacting. Five production HOM dampers are currently being fabricated at JLab. This paper outlines the challenges faced in the fabrication process, and the solutions put in place.

  11. Reduced expression of dermcidin, a peptide active against propionibacterium acnes, in sweat of patients with acne vulgaris.

    Science.gov (United States)

    Nakano, Toshiaki; Yoshino, Takashi; Fujimura, Takao; Arai, Satoru; Mukuno, Akira; Sato, Naoya; Katsuoka, Kensei

    2015-09-01

    Dermcidin (DCD), an antimicrobial peptide with a broad spectrum of activity against bacteria such as Propionibacterum acnes, is expressed constitutively in sweat in the absence of stimulation due to injury or inflammation. The aim of this study was to determine the relationship between DCD expression and acne vulgaris associated with P. acnes. The antimicrobial activity of recombinant full-length DCD (50 μg/ml) was 97% against Escherichia coli and 100% against Staphylococcus aureus. Antimicrobial activity against P. acnes ranged from 68% at 50 μg/ml DCD to 83% at 270 μg/ml DCD. DCD concentration in sweat from patients with acne vulgaris (median 9.8 μg/ml, range 6.9-95.3 μg/ml) was significantly lower than in healthy subjects (median 136.7 μg/ml, range 45.4-201.6 μg/ml) (p = 0.001). DCD demonstrated concentration-dependent, but partial, microbicidal activity against P. acnes. These results suggest that reduced DCD concentration in sweat in patients with inflammatory acne may permit proliferation of P. acnes in pilosebaceous units, resulting in progression of inflammatory acne.

  12. Commissioning of the 400 MHz LHC RF System

    CERN Document Server

    Ciapala, Edmond; Baudrenghien, P; Brunner, O; Butterworth, A; Linnecar, T; Maesen, P; Molendijk, J; Montesinos, E; Valuch, D; Weierud, F

    2008-01-01

    The installation of the 400 MHz superconducting RF system in LHC is finished and commissioning is under way. The final RF system comprises four cryo-modules each with four cavities in the LHC tunnel straight section round IP4. Also underground in an adjacent cavern shielded from the main tunnel are the sixteen 300 kW klystron RF power sources with their high voltage bunkers, two Faraday cages containing RF feedback and beam control electronics, and racks containing all the slow controls. The system and the experience gained during commissioning will be described. In particular, results from conditioning the cavities and their movable main power couplers and the setting up of the low level RF feedbacks will be presented.

  13. Botanical and phytochemical therapy of acne: a systematic review.

    Science.gov (United States)

    Fisk, Whitney A; Lev-Tov, Hadar A; Sivamani, Raja K

    2014-08-01

    Acne is prevalent among adolescents and adults with significant psychological effects. Standard oral and topical therapies can have significant side effects including skin irritation, gastrointestinal upset, and the development of drug-resistant bacteria. The use of botanicals and phytochemicals in dermatological products is increasingly popular, and many patients are turning to these alternative therapies for treatment of acne. This study aimed to systematically review clinical studies that have investigated the use of botanical agents in the treatment of acne. PubMed and Embase databases were searched in March 2013 for trials assessing botanical therapies in the treatment of acne vulgaris. Data from these trials are presented, and methodology of each study is assessed. Twenty-three trials met inclusion criteria. Interventions included plant extracts, herbal formulations, and phytochemicals. All studies reported favorable results, and several showed equal or superior treatment to standard therapies. No serious adverse events were reported. Few studies were methodologically rigorous. Each botanical was studied in only one or two trials. Botanicals are promising therapies for acne vulgaris although further research is warranted, especially with regard to severe acne and acne resistant to conventional therapy. There is a need for standardized methods for grading acne and assessing therapeutic effects. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Fractional CO2 laser resurfacing for atrophic acne scars

    DEFF Research Database (Denmark)

    Hedelund, Lene; Haak, Christina Skovbølling; Togsverd-Bo, Katrine

    2012-01-01

    The treatment of acne scars with fractional CO(2) lasers is gaining increasing impact, but has so far not been compared side-by-side to untreated control skin.......The treatment of acne scars with fractional CO(2) lasers is gaining increasing impact, but has so far not been compared side-by-side to untreated control skin....

  15. Severe acne vulgaris and tobacco smoking in young men.

    Science.gov (United States)

    Klaz, Itay; Kochba, Ilan; Shohat, Tzipora; Zarka, Salman; Brenner, Sarah

    2006-08-01

    As the relationship between tobacco smoking and acne remains unclear, we examined the relationship between cigarette smoking and severe acne in a large cohort of young men. Trained nurses interviewed subjects upon discharge from compulsory military service, regarding family history, habits, and tobacco smoking habits. Data was correlated with severe acne status, as diagnosed and coded by board-certified dermatologists. In total, 27,083 male subjects participated in the study from 1983 to 2003, of which 237 (0.88%) had severe acne, 11,718 (43.27%) were active smokers, and 15,365 (56.73%) were nonsmokers at the time of interviews. Active smokers showed a significantly lower prevalence of severe acne (0.71%) than nonsmokers (1.01%) (P = 0.0078). An inverse dose-dependent relationship between severe acne prevalence and daily cigarette consumption became significant from 21 cigarettes a day (chi2 and trend test: P < 0.0001), odds ratio: 0.2 (95% CI: 0.06-0.63). The study did not aim to establish a temporal correlation, and passive smoking and acne treatments were not measured. Previous in vitro and clinical studies strongly support an association with nicotine. We suggest a trial with topical nicotine treatment for acne to further investigate this association.

  16. Beliefs, perceptions and psychological impact of Acne vulgaris ...

    African Journals Online (AJOL)

    Background: There is a paucity of reports in the literature detailing the assessment of the beliefs,perception and psychological impact of acne patients . This is the first study from Saudi Arabia designed to address this issue. Materials and methods: A voluntary self-completed questionnaire was used to collect data from acne ...

  17. The epidemiology of acne vulgaris in late adolescence.

    Science.gov (United States)

    Lynn, Darren D; Umari, Tamara; Dunnick, Cory A; Dellavalle, Robert P

    2016-01-01

    Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15-19-year olds) remains lacking. To assess the global burden of the disease associated with acne vulgaris for late adolescents (15-19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Database summary study. Global Burden of Disease Study 2010 database. Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Geographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous opportunities for enhanced patient care. To that end, we highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence.

  18. Management of mild to moderate acne vulgaris | Malahlela | South ...

    African Journals Online (AJOL)

    Acne is a chronic inflammatory disease of the pilosebaceous units. It is the most common diagnosis in dermatology and regularly affects adolescents and young adults. Acne can be mild, moderate or severe. Treatment includes topical keratolytics, topical retinoids, antibiotics, hormonal therapy and systemic retinoids in ...

  19. Systemic isotretinoin in the management of acne – a patient ...

    African Journals Online (AJOL)

    Background: The primary aim was to investigate the appropriateness (as outlined in the South African Acne Treatment Guideline1) for the prescription of systemic isotretinoin in the management and counselling of acne in the Nelson Mandela Bay Metropole. Methods: A questionnaire was distributed to patients receiving ...

  20. Evaluation of Azithromycin in Treatment of Acne Vulgaris Compared to

    African Journals Online (AJOL)

    Introduction: Acne vulgaris is the most common dermatological disorder in adolescence. Treatment is essential to prevent physical and psychological scarring. Although many treatments for acne are available, effective management has become increasingly challenging with the emergence of antibiotic-resistant strains of ...

  1. Acné: un nuevo aporte terapéutico Acne: a new therapeutical approach

    Directory of Open Access Journals (Sweden)

    C. M. M. Paiva

    2007-06-01

    Full Text Available El acné es una patología que afecta casi al 80% de la población en algún momento de la vida. Múltiples terapéuticas locales y generales han sido utilizadas. En el presente estudio evaluamos la eficacia y seguridad del tratamiento de las lesiones activas de acné con luz pulsada como única terapéutica. Fueron tratados 91 pacientes y los resultados indican que la fototerapia es una opción terapéutica local con pocos efectos colaterales que evitaría el uso de drogas por vía general. Estos resultados fueron obtenidos en un período promedio de 4 semanas.Acne is a very common disease which affects a lot of people around the world. Multiple treatments options are available nowadays. In this study we evaluate the efficacy of IPL in active lesions of acne, as unique therapy. We treated 91 patients and results show the reduction of lesions in periods of follow-up between 4 to 6 weeks and provide a non-invasive alternative with drugs with potential secondary effects.

  2. An innovative approach to the topical treatment of acne

    Directory of Open Access Journals (Sweden)

    Sparavigna A

    2015-04-01

    Full Text Available Adele Sparavigna, Beatrice Tenconi, Ileana De Ponti, Laura La PennaDermIng srl, Clinical Research and Bioengineering Institute, Monza, MB, ItalyAbstract: Acne is characterized by primary lesions on the face, chest, and back, and by a variety of other signs and symptoms. In particular, acne inflammatory lesions result from Propionibacterium acnes colonization and are of particular relevance as they can cause permanent scarring. Acne also causes significant psychological morbidity in affected patients. Products currently available for the treatment of acne include systemic and topical treatments. As these products can cause severe side effects, new, innovative therapies are needed. Farmaka Acne Cream (FAC is a novel, film-forming cream developed to treat mild and moderate acne. In vitro studies have demonstrated that FAC is as effective as 5% benzoyl peroxide in inhibiting growth of P. acnes. In 32 subjects with mild or moderate acne, FAC reduced all the major signs and symptoms of the disease. These included itching, erythema, and scaling, as well as reductions in the numbers of papules, pustules, and open and closed comedones. Acne severity improved in 38% of subjects, while none worsened. FAC was found to be effective in controlling sebum secretion, and was non-comedogenic. Most subjects (90% reported tolerability as good or very good, while clinical efficacy and cosmetic acceptability were judged as good. For assessment of contact sensitization and photosensitization, FAC was applied daily to the backs of 29 subjects in two symmetric areas for 10 days. Using a solar stimulator, one minimal erythema dose was delivered to one side of the back from days 11 to 13. The four different subareas of treated/untreated and irradiated/nonirradiated and combinations thereof were compared. No cases of contact sensitization or photosensitization were observed, and FAC is considered safe for use in intense sunlight. In vitro and in vivo studies provide

  3. The LANSCE 805 MHZ RF System History and Status

    CERN Document Server

    Lynch, Michael; Tallerico, Paul J

    2005-01-01

    The Los Alamos Neutron Science Center (LANSCE) linear accelerator runs at 201.25 MHz for acceleration to 100 MeV. The remainder of the acceleration to 800 MeV is at 805 MHz. This is done with 44 accelerator cavity stages driven by 805 MHz klystrons. Each klystron has a peak power capability of 1.25 MeV. Originally, 97 klystrons were purchased, which was 70 from Varian/CPI and 27 from Litton. The 44 RF systems are laid out in sectors with either 6 or 7 klystrons per sector. The klystrons in each sector are powered from a common HV sytem. The current arrangement uses the Varian/CPI klystrons in 6 of the 7 sectors and Litton klystrons in the remaining sector. With that arrangement there are 38 CPI klystrons installed and 1 spare klystron per sector and 6 Litton klystrons installed in the final sector with 2 spares. The current average life of all of the operating and spare klystrons (52 total) is >112,000 filament hours and >93,000 HV hours. That is three times the typical klystron lifetime today f...

  4. Proteomic identification of secreted proteins of Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Holland Carsten

    2010-08-01

    Full Text Available Abstract Background The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as acne vulgaris. To date, the underlying disease-causing mechanisms remain ill-defined and knowledge of P. acnes virulence factors remains scarce. Here, we identified proteins secreted during anaerobic cultivation of a range of skin and clinical P. acnes isolates, spanning the four known phylogenetic groups. Results Culture supernatant proteins of P. acnes were separated by two-dimensional electrophoresis (2-DE and all Coomassie-stained spots were subsequently identified by MALDI mass spectrometry (MALDI-MS. A set of 20 proteins was secreted in the mid-exponential growth phase by the majority of strains tested. Functional annotation revealed that many of these common proteins possess degrading activities, including glycoside hydrolases with similarities to endoglycoceramidase, β-N-acetylglucosaminidase and muramidase; esterases such as lysophospholipase and triacylglycerol lipase; and several proteases. Other secreted factors included Christie-Atkins-Munch-Petersen (CAMP factors, glyceraldehyde 3-phosphate dehydrogenase (GAPDH, and several hypothetical proteins, a few of which are unique to P. acnes. Strain-specific differences were apparent, mostly in the secretion of putative adhesins, whose genes exhibit variable phase variation-like sequence signatures. Conclusions Our proteomic investigations have revealed that the P. acnes secretome harbors several proteins likely to play a role in host-tissue degradation and inflammation. Despite a large overlap between the secretomes of all four P. acnes phylotypes, distinct differences between predicted host-tissue interacting proteins were identified, providing potential insight into the differential virulence

  5. Novel techniques for enhancement and segmentation of acne vulgaris lesions.

    Science.gov (United States)

    Malik, A S; Humayun, J; Kamel, N; Yap, F B-B

    2014-08-01

    More than 99% acne patients suffer from acne vulgaris. While diagnosing the severity of acne vulgaris lesions, dermatologists have observed inter-rater and intra-rater variability in diagnosis results. This is because during assessment, identifying lesion types and their counting is a tedious job for dermatologists. To make the assessment job objective and easier for dermatologists, an automated system based on image processing methods is proposed in this study. There are two main objectives: (i) to develop an algorithm for the enhancement of various acne vulgaris lesions; and (ii) to develop a method for the segmentation of enhanced acne vulgaris lesions. For the first objective, an algorithm is developed based on the theory of high dynamic range (HDR) images. The proposed algorithm uses local rank transform to generate the HDR images from a single acne image followed by the log transformation. Then, segmentation is performed by clustering the pixels based on Mahalanobis distance of each pixel from spectral models of acne vulgaris lesions. Two metrics are used to evaluate the enhancement of acne vulgaris lesions, i.e., contrast improvement factor (CIF) and image contrast normalization (ICN). The proposed algorithm is compared with two other methods. The proposed enhancement algorithm shows better result than both the other methods based on CIF and ICN. In addition, sensitivity and specificity are calculated for the segmentation results. The proposed segmentation method shows higher sensitivity and specificity than other methods. This article specifically discusses the contrast enhancement and segmentation for automated diagnosis system of acne vulgaris lesions. The results are promising that can be used for further classification of acne vulgaris lesions for final grading of the lesions. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Acne vulgaris: Perceptions and beliefs of Saudi adolescent males

    Science.gov (United States)

    Al-Natour, Sahar H.

    2017-01-01

    INTRODUCTION: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal. OBJECTIVES: To evaluate the perceptions and beliefs of Saudi youth on acne. MATERIALS AND METHODS: Three hundred twenty-nine male students (aged 13–22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Data were analyzed by SPSS version 15.0. Results of subjects with acne, a family history of acne, and parents' educational levels were compared. Differences between the analyzed groups were assessed by a Chi-square test; p ≤ 0.05 was considered statistically significant. RESULTS: Over half (58.9%) of the participants considered acne a transient condition not requiring therapy. Only 13.1% knew that the proper treatment of acne could take a long time, even several years. Over half (52%) thought acne can be treated from the first or after few visits to the doctor. Popular sources of information were television/radio (47.7%), friends (45.6%), and the internet (38%). Only 23.4% indicated school as a source of knowledge. Reported causal factors included scratching (88.5%) and squeezing (82.1%) of pimples, poor hygiene (83.9%), poor dietary habits (71.5%), and stress (54.1%). Ameliorating factors included frequent washing of the face (52.9%), exercise (41.1%), sunbathing (24.1%), and drinking of mineral water (21%). The correlations of these facts are discussed. CONCLUSION: Results of this study point out that misconceptions of acne are widespread among Saudi youth. A health education program is needed to improve the understanding of the condition. PMID:28163574

  7. Generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Karthika Selvan

    2012-01-01

    Full Text Available Introduction: Antigen-specific antibody has been widely used for immunological analysis in the field of diagnosis as well as in pure scientific research, where the IgY antibodies can be raised against P acnes antigen. Material and Methods: To produce IgY against Propionibacterium acnes, laying hens were immunized with P acnes (MTCC No: 1951 and subsequent booster injections were given. The antibodies produced were purified from the egg yolk of immunized chicken using the polyethylene glycol and ammonium sulfate precipitation method and, further, by Diethylaminoethyl (DEAE cellulose ion-exchange column chromatography. The protein fraction of IgY was isolated from the egg yolk. The separation was rapid, and the success of each step was viewed on Sodium Dodecyl Sulphate-polyacrylamide gel electrophoresis (SDS-PAGE. The reactivity of anti-P acnes was evaluated by the Enzyme-linked immunosorbent assay (ELISA test and the dot-immunoassay. Results: With ELISA, the highest titter of 1:10000 was observed on the 150 th day after vaccination. The results of dot-immunoassay suggested that anti-P acnes IgY developed a brown color as positive reaction, which showed the antigen-antibody binding even after a maximum dilution of 1/500. These results suggest that anti-acne IgY was produced and had strong specific antibody reactivity. Conclusion: The findings indicate that anti-acne IgY is worth utilizing as a preventive agent for acne vulgaris.

  8. Steroid acne vs. Pityrosporum folliculitis: the incidence of Pityrosporum ovale and the effect of antifungal drugs in steroid acne.

    Science.gov (United States)

    Yu, H J; Lee, S K; Son, S J; Kim, Y S; Yang, H Y; Kim, J H

    1998-10-01

    Steroid acne is a folliculitis that can result from systemic or topical administration of steroid, and has been described as showing a similar clinical picture to Pityrosporum folliculitis, but there have been few reports about the incidence of Pityrosporum ovale and the effect of antimycotic drugs in steroid acne and other acneiform eruptions. Our purpose was to describe the association between steroid acne and P. ovale, and to confirm the superior efficacy of oral antifungal drugs over anti-acne drugs in the treatment of steroid acne. The history, clinical features direct microscopy, histopathologic analysis, and therapeutic results of 125 cases with steroid acne or other acneiform eruptions were described and compared. Over 80% of patients with acneiform eruption receiving systemic steroid revealed significant numbers of P. ovale in the lesional follicle. Furthermore, oral antifungal drug (itraconazole) showed significantly better clinical and mycologic effects than any other group of medications used in this study. Steroid acne and other acneiform eruptions showing discrete follicular papules and/or pustules localized to the upper trunk and acneiform facial skin lesions associated with multiple acneiform lesions on the body in the summer period should be suspected as Pityrosporum folliculitis. In addition, oral antifungal drugs recommended for Pityrosporum folliculitis; however, it will require a larger case-control study to confirm the superiority of antifungal therapy over anti-acne treatment.

  9. The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne.

    Science.gov (United States)

    Zhu, Jiang-Ting; Xuan, Min; Zhang, Ya-Ni; Liu, Hong-Wei; Cai, Jin-Hui; Wu, Yan-Hong; Xiang, Xiao-Fei; Shan, Gui-Qiu; Cheng, Biao

    2013-07-01

    The aim of this study was to evaluate the efficacy of autologous platelet-rich plasma (PRP) combined with erbium fractional laser therapy for facial acne or acne scars. PRP combined with erbium fractional laser therapy was used for the treatment of 22 patients, including 16 patients who suffered from facial acne scars and 6 patients who suffered from acne scars concomitant with acne. Whole blood (40 ml) was collected from each patient, and following differential centrifugation, PRP was harvested. After using an erbium fractional laser, we applied PRP to the entire face of every patient. Digital photos were taken before and after the treatment for evaluation by dermatologists and the patients rated the efficacy on a 5-point scale. The erythema was moderate or mild, while its total duration was 50%, and 91% of the patients were satisfied; no acne inflammation was observed after treatment. PRP combined with erbium fractional laser therapy is an effective and safe approach for treating acne scars or acne, with minimal side-effects, and it simultaneously enhanced the recovery of laser-damaged skin.

  10. Metastatic basal cell carcinoma caused by carcinoma misdiagnosed as acne - case report and literature review

    DEFF Research Database (Denmark)

    Aydin, Dogu; Hölmich, Lisbet Rosenkrantz; Jakobsen, Linda Plovmand

    2016-01-01

    Basal cell carcinoma can be misdiagnosed as acne; thus, carcinoma should be considered in treatment-resistant acne. Although rare, neglected basal cell carcinoma increases the risk of metastasis.......Basal cell carcinoma can be misdiagnosed as acne; thus, carcinoma should be considered in treatment-resistant acne. Although rare, neglected basal cell carcinoma increases the risk of metastasis....

  11. Waveform digitizing at 500 MHz

    International Nuclear Information System (INIS)

    Atiya, M.; Ito, M.; Haggerty, J.; Ng, C.; Sippach, F.W.

    1988-01-01

    Experiment E787 at Brookhaven National Laboratory is designed to study the decay K + → π + ν/bar /nu// to a sensitivity of 2 /times/ 10 -10 . To achieve acceptable muon rejection it is necessary to couple traditional methods (range/energy/momentum correlation) with observation of the (π + → μ + ν, μ + → e + ν/bar /nu//) decay sequence in scintillator. We report on the design and construction of 200 channels of relatively low cost solid state waveform digitizers. The distinguishing features are: 8 bits dynamic range, 500 MHz sampling, zero suppression on the fly, deep memory (up to .5 msec), and fast readout time (100 μsec for the entire system). We report on data obtained during the February-May 1988 run showing performance of the system for the observation of the above decay. 8 figs

  12. Waveform digitizing at 500 MHz

    International Nuclear Information System (INIS)

    Atiya, M.; Ito, M.; Haggerty, J.; Ng, C.; Sippach, F.W.

    1988-01-01

    Experiment E787 at Brookhaven National Laboratory is designed to study the decay K + → π + ν/bar /nu// to a sensitivity of 2 /times/ 10/sup /minus/10/. To achieve acceptable muon rejection it is necessary to couple traditional methods (range/energy/momentum correlation) with observation of the π + → μ + → e + ν/bar /nu// decay sequence in scintillator. We report on the design and construction of over 200 channels of relatively low cost solid state waveform digitizers. The distinguishing features are: 8 bits dynamic range, 500 MHz sampling, zero suppression on the fly, deep memory (up to .5 msec), and fast readout time (100 μsec for the entire system). We report on data obtained during the February--May 1988 run showing performance of the system for the observation of the above decay. 9 figs

  13. Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris.

    Science.gov (United States)

    Zhou, Maosong; Xie, Hongfu; Cheng, Lin; Li, Ji

    2016-01-01

    To evaluate the clinical characteristics and epidermal barrier function of papulopustular rosacea by comparing with acne vulgaris. Four hundred and sixty-three papulopustular rosacea patients and four hundred and twelve acne vulgaris patients were selected for the study in Xiangya Hospital of Central South University from March 2015 to May 2016. They were analyzed for major facial lesions, self-conscious symptoms and epidermal barrier function. Erythema, burning, dryness and itching presented in papulopustular rosacea patients were significantly higher than that in acne vulgaris patients ( P acne vulgaris patients ( P acne vulgaris patients ( P acne vulgaris patients in comparison with that of healthy subjects ( P >0.05, P acne vulgaris patients and healthy subjects ( P acne vulgaris patients than that of healthy subjects ( P acne vulgaris. The epidermal barrier function was damaged in papulopustular rosacea patients while not impaired in that of acne vulgaris patients.

  14. Superconducting spoke cavities for high-velocity applications

    Energy Technology Data Exchange (ETDEWEB)

    Hopper, Christopher S. [Old Dominion U.; Delayen, Jean R. [Old Dominion U., JLAB

    2013-10-01

    To date, superconducting spoke cavities have been designed, developed, and tested for particle velocities up to {beta}{sub 0}~0.6, but there is a growing interest in possible applications of multispoke cavities for high-velocity applications. We have explored the design parameter space for low-frequency, high-velocity, double-spoke superconducting cavities in order to determine how each design parameter affects the electromagnetic properties, in particular the surface electromagnetic fields and the shunt impedance. We present detailed design for cavities operating at 325 and 352 MHz and optimized for {beta}{sub 0}~=0.82 and 1.

  15. Baldness, acne and testicular germ cell tumors

    Science.gov (United States)

    Trabert, Britton; Sigurdson, Alice J.; Sweeney, Anne M.; Amato, Robert J.; Strom, Sara S.; McGlynn, Katherine A.

    2013-01-01

    Androgen levels during critical periods of testicular development may be involved in the etiology of testicular germ cell tumors (TGCT). We evaluated the roles of adolescent and early adult life correlates of androgen exposure and TGCT in a hospital-based case control study. TGCT cases (n=187) and controls (n=148), matched on age, race and state of residence, participated in the study. Unconditional logistic regression was used to estimate associations between TGCT and male pattern baldness, severe acne, markers of puberty onset and body size. Cases were significantly less likely to report hair loss than controls (OR, 0.6; 95% CI, 0.4, 1.0). Amount of hair loss, increasing age at onset and increasing rate of loss were all inversely associated with TGCT (rate of hair loss: p-trend=0.03; age at onset: p-trend=0.03; amount of hair loss: p-trend=0.01). History of severe acne was inversely associated with TGCT (OR, 0.5; 95% CI, 0.3, 0.9) and height was positively associated with TGCT (p-trend=0.02). Increased endogenous androgen levels during puberty and early adulthood may be associated with decreased risk of TGCT. Additional studies of endogenous hormone levels during puberty and early adult life are warranted, especially studies evaluating the role of androgen synthesis, metabolism and uptake. PMID:21128977

  16. 47 CFR 101.77 - Public safety licensees in the 1850-1990 MHz, 2110-2150 MHz, and 2160-2200 MHz bands.

    Science.gov (United States)

    2010-10-01

    ..., 2110-2150 MHz, and 2160-2200 MHz bands. 101.77 Section 101.77 Telecommunication FEDERAL COMMUNICATIONS...-1990 MHz, 2110-2150 MHz, and 2160-2200 MHz bands. (a) In order for public safety licensees to qualify... a Police licensee, a Fire Licensee, or an Emergency Medical Licensee as defined in § 90.7 of this...

  17. Treatment of acne vulgaris with fractional radiofrequency microneedling.

    Science.gov (United States)

    Kim, Sang Tae; Lee, Kang Hoon; Sim, Hyung Jun; Suh, Kee Suck; Jang, Min Soo

    2014-07-01

    Fractional radiofrequency microneedling is a novel radiofrequency technique that uses insulated microneedles to deliver energy to the deep dermis at the point of penetration without destruction of the epidermis. It has been used for the treatment of various dermatological conditions including wrinkles, atrophic scars and hypertrophic scars. There have been few studies evaluating the efficacy of fractional radiofrequency microneedling in the treatment of acne, and none measuring objective parameters like the number of inflammatory and non-inflammatory acne lesions or sebum excretion levels. The safety and efficacy of fractional radiofrequency microneedling in the treatment of acne vulgaris was investigated. In a prospective clinical trial, 25 patients with moderate to severe acne were treated with fractional radiofrequency microneedling. The procedure was carried out three times at 1-month intervals. Acne lesion count, subjective satisfaction score, sebum excretion level and adverse effects were assessed at baseline and at 4, 8 and 12 weeks after the first treatment as well as 4, 8 and 12 weeks after the last treatment. Number of acne lesions (inflammatory and non-inflammatory) decreased. Sebum excretion and subjective satisfaction were more favorable at every time point compared with the baseline values (P acne vulgaris. © 2014 Japanese Dermatological Association.

  18. High Frequency of Fibromyalgia in Patients With Acne Vulgaris.

    Science.gov (United States)

    Yazmalar, Levent; Çelepkolu, Tahsin; Batmaz, İbrahim; Sariyildiz, Mustafa Akif; Sula, Bilal; Alpayci, Mahmut; An, İsa; Burkan, Yahya Kemal; Uçak, Haydar; Çevik, Remzi

    2016-06-01

    This study aims to investigate the frequency of fibromyalgia syndrome and to specify fibromyalgia syndrome-associated clinical symptoms in patients with acne vulgaris. Eighty-eight patients (28 males, 60 females; mean age 23.2±5.1 years; range 18 to 40 years) with acne vulgaris and age, sex- and body mass index-similar 76 healthy controls (14 males, 62 females; mean age 24.5±2.9 years; range 18 to 35 years) were included. Acne vulgaris was evaluated by using the Global Acne Scale, while Hospital Anxiety and Depression Scale was used to evaluate anxiety. Fibromyalgia-associated pain, sleep disturbance, anxiety, and menstrual cycle disturbance were significantly more frequent in patients with acne vulgaris than controls. Also, the severity of anxiety and the number of tender points were significantly higher in the acne vulgaris patients than controls. This study indicates that patients with acne vulgaris have increased frequency of fibromyalgia syndrome than healthy controls (21.6% versus 5.3%, respectively).

  19. Propionibacterium acnes: A Treatable Cause of Constrictive Pericarditis

    Directory of Open Access Journals (Sweden)

    Daniel Cruz

    2015-01-01

    Full Text Available In this case report we share a case of infective Pericarditis caused by Propionibacterium acnes (P. acnes in an immune-competent, nonsurgical patient. This case and review will illustrate the importance of considering P. acnes as a cause of idiopathic pericardial effusion and effusive constrictive disease. The patient was a 61-year-old male with history of osteoarthritis of the knee. He received an intra-articular steroid injection in July 2013. Two months later, he presented with atrial fibrillation and heart failure. He was found to have pericardial and bilateral pleural effusions which grew P. acnes. This organism was initially considered to be contaminant; however, as P. acnes was isolated from both pleural and pericardial fluids, he was started on oral amoxicillin. He was noted to have recurrence of effusions within 2 weeks with evidence of constrictive physiology by echocardiography. Treatment was subsequently changed to intravenous Penicillin G with marked symptomatic improvement, resolution of pericardial/pleural effusions, and no echocardiographic evidence of constrictive pericarditis at 10 weeks follow-up. Pursuit and treatment of P. acnes could lead to prevention of constrictive pericarditis. We believe that further studies are needed to assess prevalence of P. acnes and response to intravenous Penicillin G in patients presenting with effusive constrictive disease.

  20. Electrodynamic characterisitcs measurements of higher order modes in S-band cavity

    Science.gov (United States)

    Donetsky, R.; Lalayan, M.; Sobenin, N. P.; Orlov, A.; Bulygin, A.

    2017-12-01

    The 800 MHz superconducting cavities with grooved beam pipes were suggested as one of the harmonic cavities design options for High Luminosity LHC project. Cavity simulations were carried out and scaled aluminium prototype having operational mode frequency of 2400 MHz was manufactured for testing the results of simulations. The experimental measurements of transverse shunt impedance with error estimation for higher order modes TM 110 and TE 111 for S-band elliptical cavity were done. The experiments using dielectric and metallic spherical beads and with ring probe were carried out. The Q-factor measurements for two-cell structure and array of two cells were carried out.

  1. Perpendicular biased ferrite tuned RF cavity for the TRIUMF KAON Factory booster ring

    International Nuclear Information System (INIS)

    Poirier, R.L.; Enegren, T.; Haddock, C.

    1989-03-01

    The rf cavity for the booster ring requires a frequency swing of 46 MHz to 62 MHz at a repetition rate of 50 Hz. The possibility of using the LANL booster cavity design with a yttrium garnet ferrite tuner biased perpendicular to the rf field, in the longitudinal direction, is being investigated. In order to minimize the stray magnetic biasing field on the beam axis, an alternative scheme similar to the design being proposed for the LANL main ring cavity in which the ferrite is perpendicular biased in the radial direction, is being considered. The behaviour of the rf cavity and the magnetizing circuit for both designs are discussed

  2. Use of organic acids in acne and skin discolorations therapy

    Directory of Open Access Journals (Sweden)

    Alicja Kapuścińska

    2015-03-01

    Full Text Available Acne is one of the most frequent skin disorders that occurs in puberty, but often adults also have acne. The most important factors responsible for acne are elevated production of sebum by hyperactive sebaceous glands and blockage of the follicle because of hyperkeratosis [14]. The third etiopathogenic factor of acne is excessive microflora reproduction [8]. The most significant bacterium that is responsible for formation of skin lesions is Propionibacterium acnes, a rod-shaped Gram-positive and aerotolerant anaerobic bacterium. It is estimated that P. acnes is responsible for acne in approximately 80% of people aged 11 to 30 [27,40]. Even healed skin lesions can often cause skin discolorations and scar formation [51]. Exfoliating chemical substances that are commonly used in dermatology and cosmetology are organic acids. Exfoliating treatment using organic acids is called “chemical peeling” and consists of controlled application of those substances on the skin [38]. The depth of exfoliation depends on organic acid concentration, type of substance and contact time with the skin [41]. Using exfoliating agents seems to be helpful in excessive keratinization – one of several factors responsible for acne. Moreover, epidermis exfoliation is a popular method of removing skin discoloration [22]. Considering chemical structure, exfoliating substances that are most often used in cosmetology contain alpha-hydroxyacids (glycolic acid, lactic acid, mandelic acid and citric acid, beta-hydroxyacids (salicylic acid and other organic acids, such as trichloroacetic acid and pyruvic acid [47]. In this article, a literature review of use of organic acids in acne and skin discoloration therapy is presented.

  3. Accelerating RF cavity of the Booster

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Each of the 4 PS Booster rings has a single accelerating cavity. It consists of 2 quarter-wave ferrite-loaded resonators. There are 2 figure-of-eight loops on the ferrite loads for tuning the frequency throughout the acceleration cycle, from 3 to 8 MHz (from 50 MeV at injection to the original Booster energy of 800 MeV, 2 GeV today). The cavities have a flat design, to fit the ring-to-ring distance of 36 cm. The tube for forced-air cooling is visible in the left front. See also 8301084.

  4. Accelerating RF cavity of the Booster

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    Each of the 4 PS Booster rings has a single accelerating cavity.It consists of 2 quarter-wave ferrite-loaded resonators. 2 figure-of-eight loops tune the frequency throughout the accelerating cycle, from 3 to 8 MHz (from 50 MeV at injection to the original Booster energy of 800 MeV, 2 GeV today). The cavities have a flat design, to fit the ring-to-ring distance of 36 cm, and are forced-air cooled. The 2 round objects in the front-compartments are the final-stage power-tetrodes. See also 8111095.

  5. Cryogenic system for TRISTAN superconducting RF cavity

    International Nuclear Information System (INIS)

    Hosoyama, K.; Hara, K.; Kabe, A.; Kojima, Yuuji; Ogitsu, T.; Sakamoto, Y.; Kawamura, S.; Ishimaru, Y.

    1990-01-01

    A cryogenic system consisting of a helium refrigerator (4 kW at 4.4 K) and a liquid helium distribution transfer system for TRISTAN 508 MHz 32 x 5-cell superconducting RF cavities was designed and constructed. After the performance test of the cryogenic system, 16 x 5-cell superconducting RF cavities in 8 cryostats were installed in underground TRISTAN electron-positron collider and connected to the helium refrigerator on the ground level through the transfer line (total length about 330 m) and cooled by liquid helium pool boiling in parallel. The cryogenic system and its operation experience are described. (author)

  6. Short-cavity squeezing in barium

    Science.gov (United States)

    Hope, D. M.; Bachor, H-A.; Manson, P. J.; Mcclelland, D. E.

    1992-01-01

    Broadband phase sensitive noise and squeezing were experimentally observed in a system of barium atoms interacting with a single mode of a short optical cavity. Squeezing of 13 +/- 3 percent was observed. A maximum possible squeezing of 45 +/- 8 percent could be inferred for out experimental conditions, after correction for measured loss factors. Noise reductions below the quantum limit were found over a range of detection frequencies 60-170 MHz and were best for high cavity transmission and large optical depths. The amount of squeezing observed is consistent with theoretical predictions from a full quantum statistical model of the system.

  7. ACNE VULGARIS. EVALUATION OF A MEDICATED CLEANSING PAD.

    Science.gov (United States)

    ROTH, H L

    1964-03-01

    Using the technique of simultaneous, symmetrical paired comparisons, a medicated cleansing pad that can be easily used at work or at school as an adjunctive in the treatment of acne vulgaris was evaluated.The experimental pads were significantly beneficial in reducing skin oiliness and in clinical improvement of the acne. Response to standard acne therapy was faster when the pads were used adjunctively, although the significant results seen initially tended to even out as therapy continued. Use of the medicated pads produced no untoward side effects and were well accepted by patients.

  8. ACNE VULGARIS—Evaluation of a Medicated Cleansing Pad

    Science.gov (United States)

    Roth, Harry L.

    1964-01-01

    Using the technique of simultaneous, symmetrical paired comparisons, a medicated cleansing pad that can be easily used at work or at school as an adjunctive in the treatment of acne vulgaris was evaluated. The experimental pads were significantly beneficial in reducing skin oiliness and in clinical improvement of the acne. Response to standard acne therapy was faster when the pads were used adjunctively, although the significant results seen initially tended to even out as therapy continued. Use of the medicated pads produced no untoward side effects and were well accepted by patients. PMID:14131397

  9. Hormonal Disorders as Significant Pathogenetic Factor of Acne in Women

    Directory of Open Access Journals (Sweden)

    L.O. Naumova

    2014-08-01

    Conclusions. Hormonal study of women with acne should include an assessment of the function of ovaries, adrenal glands, thyroid gland, determination of the level of prolactin in the blood plasma and glycated hemoglobin. Treatment should be aimed at management of hormonal and metabolic disorders, and topical treatment of acne. Before 30 years of age it is important to diagnose polycystic ovary syndrome and late forms of congenital dysfunction of the adrenal glands, after 30 — hyperprolactinemia syndrome, hypothyroidism, diabetes mellitus type 2, and after 40 years acne often manifests on the background of ovarian failure.

  10. 2016 American Conference on Neutron Scattering (ACNS)

    International Nuclear Information System (INIS)

    Woodward, Patrick

    2017-01-01

    The 8th American Conference on Neutron Scattering (ACNS) was held July 10-14, 2016 in Long Beach California, marking the first time the meeting has been held on the west coast. The meeting was coordinated by the Neutron Scattering Society of America (NSSA), and attracted 285 attendees. The meeting was chaired by NSSA vice president Patrick Woodward (the Ohio State University) assisted by NSSA president Stephan Rosenkranz (Argonne National Laboratory) together with the local organizing chair, Brent Fultz (California Institute of Technology). As in past years the Materials Research Society assisted with planning, logistics and operation of the conference. The science program was divided into the following research areas: (a) Sources, Instrumentation, and Software; (b) Hard Condensed Matter; (c) Soft Matter; (d) Biology; (e) Materials Chemistry and Materials for Energy; (f) Engineering and Industrial Applications; and (g) Neutron Physics.

  11. Radiotherapy of acne - a literature survey

    International Nuclear Information System (INIS)

    Maximilien, Remi.

    1983-01-01

    This review is part of a feasibility study on a follow-up survey of patients having undergone dermatologic X-ray therapy. Its main purpose is to bring up to date the knowledge on the long-term effects of the radiotherapy of seborrheic diseases and to collect any historical data contributing to the interpretation of the results of a future survey in this field. The older and modern physiopathogenic ideas on acne are first stated, and both the radiological protocols and the therapeutic associations set forth by roentgenologists in the years 1930-1960 are then described. A dosimetric and health assessment is made and the modalities of an epidemiological survey are considered [fr

  12. 2016 American Conference on Neutron Scattering (ACNS)

    Energy Technology Data Exchange (ETDEWEB)

    Woodward, Patrick [Materials Research Society, Warrendale, PA (United States)

    2017-02-09

    The 8th American Conference on Neutron Scattering (ACNS) was held July 10-14, 2016 in Long Beach California, marking the first time the meeting has been held on the west coast. The meeting was coordinated by the Neutron Scattering Society of America (NSSA), and attracted 285 attendees. The meeting was chaired by NSSA vice president Patrick Woodward (the Ohio State University) assisted by NSSA president Stephan Rosenkranz (Argonne National Laboratory) together with the local organizing chair, Brent Fultz (California Institute of Technology). As in past years the Materials Research Society assisted with planning, logistics and operation of the conference. The science program was divided into the following research areas: (a) Sources, Instrumentation, and Software; (b) Hard Condensed Matter; (c) Soft Matter; (d) Biology; (e) Materials Chemistry and Materials for Energy; (f) Engineering and Industrial Applications; and (g) Neutron Physics.

  13. Room temperature RF characterization of Nb make super conducting radio frequency cavities at RRCAT

    International Nuclear Information System (INIS)

    Mahawar, Ashish; Mohania, Praveen; Shrivastava, Purushottam; Yadav, Anand; Puntambekar, Avinash

    2015-01-01

    In order to ensure that the final welded Nb superconducting RF cavities are at the correct frequency the cavity structures are measured at various development stages for their resonant frequency. These measurements are performed at room temperature using a cavity measurement setup developed in house and a VNA. These measurements are critical to identify the length a cavity structure needs to be trimmed before welding. Measurement of resonant frequencies of Nb made cavity structures were performed for half cell, dumb bell, single cell, long end cell and short end cell structures. These structures were then joined to develop single cell and multi-cell 650 MHz/1300 MHz cavities. The present paper describes room temperature cavity characterization being carried out at RRCAT. (author)

  14. Hydroforming of Tesla Cavities at Desy

    International Nuclear Information System (INIS)

    Singer, W.; Kaiser, H.; Singer, X.; Gonin, I.; Zhelezov, I.; Khabibullin, T.; Kneisel, P.; Saito, K.

    2000-01-01

    Since several years the development of seamless niobium cavity fabrication by hydro forming is being pursued at DESY. This technique offers the possibility of lower cost of fabrication and perhaps better rf performance of the cavities because of the elimination of electron-beam welds, which in the standard fabrication technique have sometimes lead to inferior cavity performance due to defects. Several single cell 1300 MHz cavities have been formed from high purity seamless niobium tubes, which are under computer control expanded with internal pressure while simultaneously being swaged axially. The seamless tubes have been made by either back extrusion and flow forming or by spinning or deep drawing. Standard surface treatment techniques such as high temperature post purification, buffered chemical polishing (BCP), electropolishing (EP) and high pressure ultra pure water rinsing (HPR) have been applied to these cavities. The cavities exhibited high Q - values of 2 x 10 10 at 2K and residual resistances as low as 3 n(Omega) after the removal of a surface layer of app. 100 (micro)m by BCP. Surprisingly, even at high gradients up to the maximum measured values of E acc ∼ 33 MV/m the Q-value did not decrease in the absence of field emission as often observed. After electropolishing of additional 100 (micro)m one of the cavities reached an accelerating gradient of E acc (ge) 42 MV/m

  15. Differentiated treatment of patients with acne and concomitant candida infection

    Directory of Open Access Journals (Sweden)

    Yaakubi Randa

    2016-12-01

    Full Text Available There are a lot of works, which are devoted to the study of acne, but these data are often contradictory on the issue of interrelationship and interdependence of clinical manifestations, course and some factors in the pathogenesis of acne and candida infection. Aim of the research was to study the effect of the recommended differentiated therapy on the pathogenetic disorders in patients with acne and concomitant Candida infection. Methods and results. 120 patients with acne were examined. In 100 of them concomitant skin malasseziosis was set in the form of pityriasis rosea, kerosis, comedones, folliculitis, seborrhea, multicolored zoster, with some features, as well as candidiasis. Methods of the research – bacterioscopic, bacteriological, study of skin oiliness and moisture, skin pH, the level of Ca ++, parathyroid hormone and calcitonin. In patients with acne significant shifts in the composition of water-lipid mantle, increased oiliness and decreased moisture of skin, pH changes with a shift to the alkaline side were revealed, the most pronounced – in acne patients with Candida infection. The content of Ca ++ in the organism, as well as parathyroid hormone and calcitonin was increased and also the most indicative it was in patients with acne and concomitant Candida infection. After the comparative analysis on the basis of different levels of clinical and laboratory violations two clinical-therapeutic groups were distinguished, in accordance with that the differentiated therapy offered by us was conducted. Increased oiliness and Рh of skin, decline of moisture before the treatment, especially in patients with III and IV stages of acne, complicated by Candida infection, were normalized after treatment, unlike in patients treated traditionally. Conclusion. After treatment intensity of microbal colonization and also microbal associations of skin was diminished, the level of Ca++, parathyroid hormone and calcitonin went down.

  16. The epidemiology of acne vulgaris in late adolescence

    Science.gov (United States)

    Lynn, Darren D; Umari, Tamara; Dunnick, Cory A; Dellavalle, Robert P

    2016-01-01

    Importance Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15–19-year olds) remains lacking. Objective To assess the global burden of the disease associated with acne vulgaris for late adolescents (15–19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Design Database summary study. Setting Global Burden of Disease Study 2010 database. Participants Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Main outcomes and measures Geographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Conclusion and relevance Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous opportunities for enhanced patient care. To that end, we highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence. PMID:26955297

  17. Prototype of cavity for lepton acceleration in the SPS

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    The SPS was to be the injector for LEP and had to accelerate the electrons and positrons delivered by the PS. This is a prototype of a 200 MHz, single-cell, standing-wave, cavity for lepton acceleration in the SPS. On top of the cavity, at the back, is the tetrode amplifier, the tuning mechanism is leaning towards the viewer. See also 8103523 and Annual Report 1981, p.114.

  18. The Test of LLRF control system on superconducting cavity

    OpenAIRE

    Zhu, Zhenglong; Wang, Xianwu; Wen, Lianghua; Chang, Wei; Zhang, Ruifeng; Gao, Zheng; Chen, Qi

    2014-01-01

    The first generation Low-Level radio frequency(LLRF) control system independently developed by IMPCAS, the operating frequency is 162.5MHz for China ADS, which consists of superconducting cavity amplitude stability control, phase stability control and the cavity resonance frequency control. The LLRF control system is based on four samples IQ quadrature demodulation technique consisting an all-digital closed-loop feedback control. This paper completed the first generation of ADS LLRF control s...

  19. Hormonal and dietary factors in acne vulgaris versus controls.

    Science.gov (United States)

    Stewart, Thomas Jonathan; Bazergy, Carl

    2018-01-01

    Background : Acne vulgaris is an inflammatory skin disorder with not as yet fully understood pathogenesis. In this controlled study, we assessed acne vulgaris patients for several possible pathogenic factors such as vitamin D deficiency, vegan diet, increased body mass index (BMI) and positive anti-transglutaminase antibody. Methods : We screened 10 years of records at a family medicine clinic for patients diagnosed with acne vulgaris. In eligible subjects, we collected data regarding 25-hydroxylvitamin D levels, BMI, dietary preference and serum IgA tissue transglutaminase levels. Controls were age- (+/- 12 months) and sex-matched patients seen during the study period without a diagnosis of acne vulgaris. Results : 453 patients were given a diagnosis of acne vulgaris during the study period. Compared with controls, we found significant associations between vitamin D deficiency (4.0U/mL) and a diagnosis of acne vulgaris. Conclusions : Our study adds important information to the current body of literature in pursuit of elucidating the pathogenesis of this complex multifactorial disease.

  20. Novel pharmacological approaches for the treatment of acne vulgaris.

    Science.gov (United States)

    Valente Duarte de Sousa, Isabel Cristina

    2014-10-01

    Acne vulgaris is the most common skin disease worldwide; yet, current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. The adequate control of the four pathogenic mechanisms, involved in the appearance of acne lesions, is paramount to treatment success. The authors discuss and evaluate the pathogenic pathways related to the mechanisms of action of novel molecules, which are currently under investigation for the treatment of acne vulgaris. The manuscript is based on comprehensive searches made through PubMed, GoogleScholar and ClinicalTrial.gov, using different combination of key words, which include acne vulgaris, pathogenesis, treatment, sebogenesis and Propionibacterium acnes. In the near future, more effective treatments with fewer side effects are expected. The use of topical antiandrogens, acetylcholine inhibitors and PPAR modulators seem to be promising options for controlling sebum production. Retinoic acid metabolism-blocking agents and IL-1α inhibitors have the potential to become legitimate alternative options to retinoid therapy in the management of infundibular dyskeratosis. Indeed, the authors believe that there will likely be a decline in the use of antibiotics for controlling P. acnes colonization and targeting the inflammation cascade.

  1. Carrier-Based Drug Delivery System for Treatment of Acne

    Science.gov (United States)

    Vyas, Amber; Kumar Sonker, Avinesh

    2014-01-01

    Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system. PMID:24688376

  2. Acne and skin bleaching in Lomé, Togo.

    Science.gov (United States)

    Kombaté, Koussake; Mouhari-Toure, Abas; Saka, Bayaki; Akakpo, Abla Séfako; Maboudou, Akouavi; Pitché, Palokinam; Tchangaï-Walla, Kissem

    2012-11-01

    This study aims at describing the clinical characteristics of patients with acne using skin bleaching (SB) products. This is a prospective study conducted over 8 months in three dermatology departments and one private clinic. All patients examined for acne were included in the study. The study included 119 patients examined for acne from March to October 2010. Among them 48 (40.7%) did SB. Hydroquinone was the first product used for SB (26 of 48), followed by topical corticosteroids (17 of 48). The elementary lesions were papules (99.2%), comedos (36.1%), pustules (63.9%), pigmentation (26.1%), scars (21%), and nodules (20.2%). The extent of acne on the face was observed in all patients (100%). The lesions were extensive among 43.7% of the patients. The extent of acne lesions was not statistically associated with SB. Other body areas concerned were the chest (20.2%), back, and shoulders (41.2%). The relative risk of having lesions on the back and/or shoulders when the patient practiced SB was 2.71 (CI: 1.08-6.84), which is significant. The study suggests that the back and shoulders can be the main areas for acne lesions associated with the practice of SB. The influence of different types of product is unclear. © 2012 The International Society of Dermatology.

  3. An update on the management of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Jonette Keri

    2009-06-01

    Full Text Available Jonette Keri1,2, Michael Shiman11Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dermatology Service, Miami VA Hospital, FL, USAAbstract: Acne vulgaris is a common skin disorder that can affect individuals from childhood to adulthood, most often occurring in the teenage years. Acne can have a significant physical, emotional, and social impact on an individual. Many different treatment options are available for the treatment of acne vulgaris. Commonly used topical treatments include benzoyl peroxide, antibiotics, sulfur and sodium sulfacetamide, azelaic acid, and retinoids. Systemic treatment is frequently used and includes the use of systemic antibiotics, oral contraceptives, antiandrogens, and retinoids. Other treatment modalities exist such as the use of superficial chemical peels as well as using laser and light devices for the treatment of acne. With the multitude of treatment options and the rapidly expanding newer technologies available to clinicians, it is important to review and be aware of the current literature and studies regarding the treatment of acne vulgaris.Keywords: acne vulgaris, treatment, benzoyl peroxide, antibiotics, retinoids, lasers

  4. Topical antibiotic monotherapy prescribing practices in acne vulgaris.

    Science.gov (United States)

    Hoover, William D; Davis, Scott A; Fleischer, Alan B; Feldman, Steven R

    2014-04-01

    The aim of this study is to evaluate the frequency of dosing topical antibiotics as monotherapy in the treatment of acne vulgaris, and physician specialty prescribing these medications. This study is a retrospective review of all visits with a sole diagnosis of acne vulgaris (ICD-9-CM code 706.1) found on the National Ambulatory Medical Care Survey (NAMCS) in 1993-2010. We recorded the number of visits surveyed where acne vulgaris was the sole diagnosis, number of visits where topical antibiotics were the only treatment prescribed, and the specialty of physician in each encounter. Topical erythromycin or clindamycin were the sole medication prescribed in 0.81% of the visits recorded, with 60% of these prescriptions arising from dermatologists and 40% from non-dermatologists. The trend of prescribing topical antibiotic monotherapy is declining (p acnes to topical antibiotic regimens has led to the need to re-evaluate the use of topical antibiotics in the treatment of acne vulgaris. While the rate of topical antibiotic monotherapy is declining, their use should be reserved for situations where the direct need for antibiotics arises. If a clinician feels that antibiotics are a necessary component to acne therapy, they should be used as part of a combination regimen.

  5. Frequency-tunable SRF cavities for microwave opto-mechanics

    Science.gov (United States)

    Castelli, Alessandro; Martinez, Luis; Pate, Jacob; Thompson, Johnathon; Chiao, Raymond; Sharping, Jay

    Three dimensional SRF (Superconducting Radio Frequency) cavities are known for achieving high quality factors (Q =109 or higher) but suffer from limited frequency tunability once fabricated and cooled to superconducting temperatures. Our end-wall design allows for numerous applications of cavity tuning at temperatures as low as 40 millikelvin. Using a bimorphic piezoelectric transducer, we demonstrate approximately 15 MHz of resonance tunability for the TE011 mode at cryogenic temperatures in a cylindrical reactor grade niobium (Nb) cavity (10% of the range at room temperature). This range doubles when using tunable end-walls on both cavity ends. We report on techniques for improving the Q of multi-component cavities including the use of concave end-walls to reduce fields near the cylinder ends and indium O-rings to reduce resistive losses at the gaps. Three-dimensional SRF cavities of this type have potential applications to quantum information science, precision displacement metrology, and quantum electro-dynamics.

  6. Development of A 402.5 MHz 140 kW Inductive Output Tube

    International Nuclear Information System (INIS)

    Ives, R. Lawrence; Read, Michael; Jackson, Robert

    2012-01-01

    This report contains the results of Phase I of an SBIR to develop a Pulsed Inductive Output Tube (IOT) with 140 kW at 400 MHz for powering H-proton beams. A number of sources, including single beam and multiple beam klystrons, can provide this power, but the IOT provides higher efficiency. Efficiencies exceeding 70% are routinely achieved. The gain is typically limited to approximately 24 dB; however, the availability of highly efficient, solid state drivers reduces the significance of this limitation, particularly at lower frequencies. This program initially focused on developing a 402 MHz IOT; however, the DOE requirement for this device was terminated during the program. The SBIR effort was refocused on improving the IOT design codes to more accurately simulate the time dependent behavior of the input cavity, electron gun, output cavity, and collector. Significant improvement was achieved in modeling capability and simulation accuracy.

  7. Optomechanic interactions in phoxonic cavities

    Directory of Open Access Journals (Sweden)

    Bahram Djafari-Rouhani

    2014-12-01

    Full Text Available Phoxonic crystals are periodic structures exhibiting simultaneous phononic and photonic band gaps, thus allowing the confinement of both excitations in the same cavity. The phonon-photon interaction can be enhanced due to the overlap of both waves in the cavity. In this paper, we discuss some of our recent theoretical works on the strength of the optomechanic coupling, based on both photoelastic and moving interfaces mechanisms, in different (2D, slabs, strips phoxonic crystals cavities. The cases of two-dimensional infinite and slab structures will enable us to mention the important role of the symmetry and degeneracy of the modes, as well as the role of the materials whose photoelastic constants can be wavelength dependent. Depending on the phonon-photon pair, the photoelastic and moving interface mechanisms can contribute in phase or out-of-phase. Then, the main part of the paper will be devoted to the optomechanic interaction in a corrugated nanobeam waveguide exhibiting dual phononic/photonic band gaps. Such structures can provide photonic modes with very high quality factor, high frequency phononic modes of a few GHz inside a gap and optomechanical coupling rate reaching a few MHz.

  8. Superconducting radio frequency cavities: design, development and results

    International Nuclear Information System (INIS)

    Prakash, P.N.; Mistri, K.K.; Sonti, S.S.K.; Sacharias, J.; Raiand, A.; Kanjilal, D.

    2013-01-01

    In recent years, the development of superconducting niobium cavities has evoked a lot of interest among the accelerator physics community of India. Many laboratories are planning to develop superconducting niobium cavities for new accelerators and applications. Inter-University Accelerator Centre (IUAC) has been engaged in the indigenous development of niobium resonators for over a decade. During this period, several quarter wave resonators have been successfully built, tested and installed in the superconducting linac at IUAC. A new niobium low beta resonator for the High Current Injector (HCI) project has been designed, prototyped and tested. In addition to the in-house projects, IUAC is nearing completion of two niobium single spoke resonators (SSR1) for Fermi Lab, USA. Under the Indian Institutions and Fermi Lab Collaboration (IIFC), Raja Ramanna Centre for Advanced Technology, Indore and Inter-University Accelerator Centre have jointly developed TESLA-type 1.3 GHz single cell cavities which have achieved very high accelerating gradients. Buoyed by the success of this work, a 5-cell 1.3 GHz cavity with simple end tubes has been successfully built. This cavity is presently at Fermi Lab for 2 K tests. Recently, a 650 MHz, β=0.9 single cell cavity has also been successfully completed and is ready for cold tests. There are plans to develop a 650 MHz, β=0.6 single cell cavity in collaboration with VECC, Kolkata. This paper presents the status of the niobium cavities developed at Inter-University Accelerator Centre. (author)

  9. Validation of the Spanish Acne Severity Scale (Escala de Gravedad del Acné Española--EGAE).

    Science.gov (United States)

    Puig, Lluis; Guerra-Tapia, Aurora; Conejo-Mir, Julián; Toribio, Jaime; Berasategui, Carmen; Zsolt, Ilonka

    2013-04-01

    Several acne grading systems have been described, but consensus is lacking on which shows superiority. A standardized system would facilitate therapeutic decisions and the analysis of clinical trial data. To assess the feasibility, reliability, validity and sensitivity to change of the Spanish Acne Severity Scale (EGAE). A Spanish, multicentre, prospective, observational study was performed in patients with facial, back or chest acne assessed using EGAE, Leeds Revised Acne Grading system (LRAG) and lesion count. Clinicians answered 4 questions regarding EGAE use and time employed. Patients were evaluated at baseline and after 5±1 weeks. Four additional blinded observers, all dermatologists, evaluated patients' pictures using EGAE and LRAG. In total, 349 acne locations were assessed in 328 patients. Of the dermatologists, 95.6% (CI: 92.9-97.5%) reported that EGAE was easy to use, and 75% used it in 0.85; p<0.001). EGAE mean score in treatment-compliant patients was significantly lower at follow-up than at baseline (2.14 vs. 1.57, p<0.001, Cohen's d=0.35).The pre-post-treatment difference in EGAE mean score in non-compliant patients was not significant (1.44 vs. 1.32, p<0.102) and Cohen's d was lower (0.19) than in compliant patients. The use of EGAE to evaluate acne grade in daily clinical dermatological practice in Spanish centres has shown feasibility, high interobserver reliability, concurrent validity and sensitivity to detect treatment effects.

  10. Mechanical design and fabrication of a 425-MHz H- buncher

    International Nuclear Information System (INIS)

    Wilson, N.G.; Precechtel, D.

    1987-01-01

    A beam buncher has been designed, fabricated, and installed on the accelerator test stand (ATS) to match the 2-MeV output beam of a 425-MHz H - radio-frequency quadrupole (RFQ) into a 425-MHz drift-tube linac (DTL). The buncher configuration provides integral-matching permanent-magnet quadrupoles (PMQ) at the exit of the RFQ and one βλ across the buncher accelerating gap; a third PMQ is the first DTL half-cell magnet. Located between the second and third PMQs is a 50-Ω, capacitively coupled, beam-sensing pickup loop. Cooling channels are provided in each of the brazed OFHC copper wall sections. Vacuum pumping of the buncher is provided by a cryogenic refrigerator vacuum pump through an array of small-diameter holes in the buncher cavity wall. Mechanical features of the buncher, the brazing and electron-beam welding of the solid-copper buncher structure, and the beam pickup loop are described in this paper. The buncher has been tuned, installed, and operated at full power on the ATS

  11. Randomized, controlled trial split-faced study of 595-nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood.

    Science.gov (United States)

    Lekwuttikarn, Ramrada; Tempark, Therdpong; Chatproedprai, Susheera; Wananukul, Siriwan

    2017-08-01

    The high prevalence of acne vulgaris in teenagers has increased comorbidities. Lasers offer alternative options for acne treatment because they have rapid action, low systemic adverse effects, and do not require everyday treatment. To study the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood, we designed a blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm 3 pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study in patients with mild to moderate acne by comparing the laser-treated and non-treated side. The acne lesion counts, acne erythema grading, and acne severity grading were evaluated at baseline and 2, 4, and 8 weeks. Thirty patients were recruited. The results showed no statistically significant difference except the papule count at week 4 which was -1.828 on the treated side and 0.103 on the non-treated side of the face, P-value 0.0018. There was no statistically significant difference of acne severity grading and acne erythema grading between both sides of the face. The mean scores of patients' satisfaction on the laser-treated side were 75, 81, and 81%, respectively. The PDL treatment in this study reveals no significant improvement in acne therapy; however, the patients were satisfied with this laser treatment. © 2017 The International Society of Dermatology.

  12. Design study of a 25.5-MHz split coaxial RFQ

    International Nuclear Information System (INIS)

    Arai, Shigeaki; Imanishi, Akira; Morimoto, Teruhisa; Shibuya, Shinji; Tojyo, Eiki; Tokuda, Noboru.

    1989-08-01

    A 25.5-MHz split coaxial RFQ with modulated vanes is now being fabricated. The RFQ, 2.1 m in length and 0.9 m in diameter, will accelerate ions with a charge-to-mass ratio greater than 1/30 from 1 keV/n up to 45.4 keV/n. The design works on beam dynamics and cavity fabrication are reported. (author)

  13. The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity

    Directory of Open Access Journals (Sweden)

    Moerbono Mochtar

    2018-01-01

    Full Text Available Introduction. Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL- 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods. This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA study was applied to measure IL-19 serum. Result. Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. Conclusions. There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.

  14. The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity.

    Science.gov (United States)

    Mochtar, Moerbono; Murasmita, Alamanda; Irawanto, M Eko; Julianto, Indah; Kariosentono, Harijono; Waskito, Fajar

    2018-01-01

    Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum. Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.

  15. Electromagnetic radiation-2450 MHz exposure causes cognition ...

    Indian Academy of Sciences (India)

    83

    Electromagnetic radiation-2450 MHz exposure causes cognition deficit with mitochondrial. 1 ... decrease in levels of acetylcholine, and increase in activity of acetyl ...... neuronal apoptosis and cognitive disturbances in sevoflurane or propofol ...

  16. New Control Structure of the 200 MHz RF System in the CERN PS

    CERN Document Server

    Damerau, H; CERN. Geneva. AB Department

    2008-01-01

    The 200 MHz RF system is an essential tool for the preparation of high-intensity beams in the CERN PS. Presently, six RF cavities are operated to control the longitudinal bunch emittance and rebunching of the beam before the transfer to the SPS. Cavities are selected for the various processes with a dedicated hardware matrix, switching the individual timing pulses and voltage programs per cavity. However, the electronics used for the matrix hardware is obsolete and its reliability cannot be guaranteed due to a lack of spare modules and components. Instead of replacing the old hardware matrix by modern hardware, this note describes a new control structure for the 200MHz RF system so that no dedicated hardware will be required anymore. The implementation of the new control structure is based on two main concepts. Firstly, linked timing trees per blow-up or rebunching are used to handle all related timing and to store one row of the matrix. Secondly, as a reflection of the RF signal generation for the 200 MHz sy...

  17. A pilot study on efficacy treatment of acne vulgaris using a new method: results of a randomized double-blind trial with Acne Dressing.

    Science.gov (United States)

    Chao, Chao-Ming; Lai, Wei-Yu; Wu, Bai-Yao; Chang, Hung-Chia; Huang, Wei-Shuan; Chen, Yu-Fei

    2006-01-01

    For many years the positive effect of hydrocolloid dressings on skin-related conditions attracted the attention of the medical scientific community. The use of Acne Dressing, a tape of hydrocolloid dressing, for the treatment of acne has not been reported previously. The aim of this study was to evaluate the clinical efficacy and beneficial effect of Acne Dressing on the marker for sebum output evaluations. We also determined the cosmetic outcome of this application during the treatment of acne and whether the material could prevent hand touching and UVB light from reaching the skin surface. The objective of this study was to assess improvement in acne vulgaris and tolerability during one week of short contact treatment with Acne Dressing compared to skin tapes. Efficacy data specific to treatment of acne vulgaris with Acne Dressing (3M Health Care) from a double-blind, randomized, skin types-controlled study is reported. A total of 20 patients with mild-to-moderate acne vulgaris applied the skin tapes or Acne Dressing every two days for up to one week. Twenty patients were enrolled in this study: ten patients received Acne Dressing and ten patients received skin tapes. Both groups showed decreases from baseline to the end of treatment in the mean of the overall severity scale (decrease of 1.37 from 1.8 to 0.43 with Acne Dressing and 0.28 from 1.08 to 0.8 with skin tapes). A statistically significant greater reduction was observed over a period of three to seven days in the overall severity of acne and inflammation in the Acne Dressing group compared with the mono-therapy (skin tapes) group. Similarly, Acne Dressing resulted in a significantly greater improvement in the redness, oiliness, dark pigmentation, and sebum casual level at days 3, 5, and 7. The ratio of transmission of UVB light with Acne Dressing was 7.4%, and 38% with skin tapes, which shows less UVB light reaching the skin surface with the Acne Dressing. No significant adverse events were identified in

  18. Providing primary standard calibrations beyond 20 MHz

    International Nuclear Information System (INIS)

    Bickley, C J; Zeqiri, B; Robinson, S P

    2004-01-01

    The number of applications of medical ultrasound utilising frequencies in excess of 20 MHz has shown a consistent increase over recent years. Coupled with the commercial availability of wide-bandwidth hydrophones whose response extends beyond 40 MHz, this has driven a growing need to develop hydrophone calibration techniques at elevated frequencies. The current National Physical Laboratory primary standard method of calibrating hydrophones is based on an optical interferometer. This has been in operation for around 20 years and provides traceability over the frequency range of 0.3 to 20 MHz. More recently, calibrations carried out using the interferometer have been extended to 60 MHz, although the uncertainties associated with these calibrations are poor, being in excess of ±20% at high frequencies. Major contributions to the degraded calibration uncertainties arise from poor signal-to-noise at higher frequencies, the frequency response of the photodiodes used and the noise floor of the instrument. To improve the uncertainty of hydrophone calibrations above 20 MHz, it has been necessary to build and commission a new interferometer. Important features of the new primary standard are its use of a higher power laser to improve the signal-to-noise ratio, along with photodiodes whose greater bandwidth to improve the overall frequency response. This paper describes the design of key aspects of the new interferometer. It also presents some initial results of the performance assessment, including a detailed comparison of calibrations of NPL reference membrane hydrophones, undertaken using old and new interferometers for calibration up to 40 MHz

  19. Study of CSR longitudinal bunch compression cavity

    International Nuclear Information System (INIS)

    Yin Dayu; Li Peng; Liu Yong; Xie Qingchun

    2009-01-01

    The scheme of longitudinal bunch compression cavity for the Cooling Storage Ring (CSR)is an important issue. Plasma physics experiments require high density heavy ion beam and short pulsed bunch,which can be produced by non-adiabatic compression of bunch implemented by a fast compression with 90 degree rotation in the longitudinal phase space. The phase space rotation in fast compression is initiated by a fast jump of the RF-voltage amplitude. For this purpose, the CSR longitudinal bunch compression cavity, loaded with FINEMET-FT-1M is studied and simulated with MAFIA code. In this paper, the CSR longitudinal bunch compression cavity is simulated and the initial bunch length of 238 U 72+ with 250 MeV/u will be compressed from 200 ns to 50 ns.The construction and RF properties of the CSR longitudinal bunch compression cavity are simulated and calculated also with MAFIA code. The operation frequency of the cavity is 1.15 MHz with peak voltage of 80 kV, and the cavity can be used to compress heavy ions in the CSR. (authors)

  20. Development of vertical electropolishing process applied on 1300 and 704 MHz superconducting niobium resonators

    Directory of Open Access Journals (Sweden)

    F. Eozénou

    2014-08-01

    Full Text Available An advanced setup for vertical electropolishing of superconducting radio-frequency niobium elliptical cavities has been installed at CEA Saclay. Cavities are vertically electropolished with circulating standard HF-HF-H_{2}SO_{4} electrolytes. Parameters such as voltage, cathode shape, acid flow, and temperature have been investigated. A low voltage (between 6 and 10 V depending on the cavity geometry, a high acid flow (25  L/min, and a low acid temperature (20° C are considered as promising parameters. Such a recipe has been tested on single-cell and nine-cell International Linear Collider (ILC as well as 704 MHz five-cell Super Proton Linac (SPL cavities. Single-cell cavities showed similar performances at 1.6 K being either vertically or horizontally electropolished. The applied baking process provides similar benefit. An asymmetric removal is observed with faster removal in the upper half-cells. Multicell cavities (nine-cell ILC and five-cell SPL cavities exhibit a standard Q_{0} value at low and medium accelerating fields though limited by power losses due to field emitted electrons.

  1. 805 MHz Beta = 0.47 Elliptical Accelerating Structure R & D

    Energy Technology Data Exchange (ETDEWEB)

    S. Bricker; C. Compton; W. Hartung; M. Johnson; F. Marti; J. Popierlarski; R. C. York; et al

    2008-09-22

    A 6-cell 805 MHz superconducting cavity for acceleration in the velocity range of about 0.4 to 0.53 times the speed of light was designed. After single-cell prototyping, three 6-cell niobium cavities were fabricated. In vertical RF tests of the 6-cell cavities, the measured quality factors (Q{sub 0}) were between 7 {center_dot} 10{sup 9} and 1.4 {center_dot} 10{sup 10} at the design field (accelerating gradient of 8 to 10 MV/m). A rectangular cryomodule was designed to house 4 cavities per cryomodule. The 4-cavity cryomodule could be used for acceleration of ions in a linear accelerator, with focusing elements between the cryomodules. A prototype cryomodule was fabricated to test 2 cavities under realistic operating conditions. Two of the 6-cell cavities were equipped with helium tanks, tuners, and input coupler and installed into the cryomodule. The prototype cryomodule was used to verify alignment, electromagnetic performance, frequency tuning, cryogenic performance, low-level RF control, and control of microphonics.

  2. 805 MHz β = 0.47 Elliptical Accelerating Structure R and D. Final Report

    International Nuclear Information System (INIS)

    Bricker, S.; Compton, C.; Hartung, W.; Johnson, M.; Marti, F.; Popierlarski, J.; York, R.C.

    2008-01-01

    A 6-cell 805 MHz superconducting cavity for acceleration in the velocity range of about 0.4 to 0.53 times the speed of light was designed. After single-cell prototyping, three 6-cell niobium cavities were fabricated. In vertical RF tests of the 6-cell cavities, the measured quality factors (Q 0 ) were between 7 · 10 9 and 1.4 · 10 10 at the design field (accelerating gradient of 8 to 10 MV/m). A rectangular cryomodule was designed to house 4 cavities per cryomodule. The 4-cavity cryomodule could be used for acceleration of ions in a linear accelerator, with focusing elements between the cryomodules. A prototype cryomodule was fabricated to test 2 cavities under realistic operating conditions. Two of the 6-cell cavities were equipped with helium tanks, tuners, and input coupler and installed into the cryomodule. The prototype cryomodule was used to verify alignment, electromagnetic performance, frequency tuning, cryogenic performance, low-level RF control, and control of microphonics.

  3. RF BREAKDOWN STUDIES USING PRESSURIZED CAVITIES

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland

    2014-09-21

    Many present and future particle accelerators are limited by the maximum electric gradient and peak surface fields that can be realized in RF cavities. Despite considerable effort, a comprehensive theory of RF breakdown has not been achieved and mitigation techniques to improve practical maximum accelerating gradients have had only limited success. Part of the problem is that RF breakdown in an evacuated cavity involves a complex mixture of effects, which include the geometry, metallurgy, and surface preparation of the accelerating structures and the make-up and pressure of the residual gas in which plasmas form. Studies showed that high gradients can be achieved quickly in 805 MHz RF cavities pressurized with dense hydrogen gas, as needed for muon cooling channels, without the need for long conditioning times, even in the presence of strong external magnetic fields. This positive result was expected because the dense gas can practically eliminate dark currents and multipacting. In this project we used this high pressure technique to suppress effects of residual vacuum and geometry that are found in evacuated cavities in order to isolate and study the role of the metallic surfaces in RF cavity breakdown as a function of magnetic field, frequency, and surface preparation. One of the interesting and useful outcomes of this project was the unanticipated collaborations with LANL and Fermilab that led to new insights as to the operation of evacuated normal-conducting RF cavities in high external magnetic fields. Other accomplishments included: (1) RF breakdown experiments to test the effects of SF6 dopant in H2 and He gases with Sn, Al, and Cu electrodes were carried out in an 805 MHz cavity and compared to calculations and computer simulations. The heavy corrosion caused by the SF6 components led to the suggestion that a small admixture of oxygen, instead of SF6, to the hydrogen would allow the same advantages without the corrosion in a practical muon beam line. (2) A

  4. Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne

    Directory of Open Access Journals (Sweden)

    Fatemeh Mokhtari

    2016-01-01

    Conclusion: Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.

  5. Could Probiotics Be the Next Big Thing in Acne and Rosacea Treatments?

    Science.gov (United States)

    ... facts News releases News 30 January 2014 Could probiotics be the next big thing in acne and ... Dermatologists encouraged by early research showing link between probiotic use and clearer skin in acne and rosacea ...

  6. Acne in adolescents: quality of life, self-esteem, mood, and psychological disorders.

    Science.gov (United States)

    Dunn, Lauren K; O'Neill, Jenna L; Feldman, Steven R

    2011-01-15

    Acne is a significant adolescent problem and may precipitate emotional and psychological effects. The impact of acne on psychological parameters and implications for acne treatment are not fully understood. We performed a MEDLINE search using the terms "acne" and "adolescent" along with "psychological," "depression," or "psychiatric," which yielded 16 reviewed studies. Qualitative review of the selected articles revealed that the presence of acne has a significant impact on self-esteem and quality of life. Depression and other psychological disorders are more prevalent in acne patients and acne treatment may improve symptoms of these disorders. The reviewed studies were semi-quantitative analyses utilizing various standardized surveys or questionnaires. Therefore, quantitative analysis of selected studies was not possible. The presence of co-morbid psychological disorders should be considered in the treatment of acne patients and future prospective trials are needed to assess the impact of treatment on psychological outcomes.

  7. Calculation of mechanical vibration frequencies of stiffened superconducting cavities

    International Nuclear Information System (INIS)

    Black, S.J.; Spalek, G.

    1992-01-01

    We calculated the frequencies of transverse and longitudinal mechanical-vibration modes of the HEPL- modified, CERN/DESY four-cell superconducting cavity, using finite-element techniques. We compared the results of these calculations, including the stiffening of the cavity with rods, with mode frequencies measured at HEPL. The correlation between data was significant. The same techniques were also used to design and optimize the stiffening scheme for the seven-cell 805-MHz superconducting cavity being developed at Los Alamos. In this report, we describe the final stiffening scheme and the results of our calculations

  8. Calculation of mechanical vibration frequencies of stiffened superconducting cavities

    International Nuclear Information System (INIS)

    Black, S.J.; Spalek, G.

    1992-01-01

    We calculated the frequencies of transverse and longitudinal mechanical-vibration modes of the HEPL-modified, CERN/DESY four-cell superconducting cavity, using finite-element techniques. We compared the results of these calculations, including the stiffening of the cavity with rods, with mode frequencies measured at HEPL. The correlation between data was significant. The same techniques were also used to design and optimize the stiffening scheme for the seven-cell 805-MHz superconducting cavity being developed at Los Alamos. In this report, we describe the final stiffening scheme and the results of our calculations. (Author) 6 figs., 5 tabs., 4 refs

  9. RF-cavity for the X-ray generator NESTOR

    International Nuclear Information System (INIS)

    Androsov, V.P.; Gvozd, A.M.; Karnaukhov, I.M.; Telegin, Yu.N.; Chernov, K.N.; Ostreyko, G.N.; Sedlyarov, I.K.

    2007-01-01

    In the Kharkov Institute of Physics and Technology 225 MeV electron storage ring NESTOR is under development. The paper describes the design and parameters of a 700 MHz cavity that has been fabricated at BINP for the NESTOR RF-system. Now the low-power and vacuum tests of the cavity are under way at BINP. We present here the results of 3D simulations of the cavity with ANSYS code. The problem of multibunch instabilities in NESTOR is also discussed

  10. Progress on a prototype main ring rf cavity

    International Nuclear Information System (INIS)

    Swain, G.; Kandarian, R.; Thiessen, H.A.; Poirier, R.; Smythe, W.R.

    1989-01-01

    A prototype rf cavity and rf drive system for a hadron facility main ring has been designed and will be tested in the Proton Storage Ring (PSR) at Los Alamos as a part of a collaborative effort between LANL and TRIUMF. The cavity uses an orthogonally biased ferrite tuner. The design provides for accelerating gap voltages up to 200 kV for the 49.3 to 50.8 MHz range. Progress on the cavity construction and testing is described. 13 refs., 5 figs

  11. Teens and Technology Transforming Acne Treatment.

    Science.gov (United States)

    Ettel, Donna Lee; Lamanno, Lora Rose; Neyra, Sarah Anne; Ettel, Wallace John; Ettel, George Leonard; Mitchell, Matthew Kevin

    2017-01-01

    Although the Internet contains many health Web sites with valid information, it also contains sites with false information. To learn whether high school students searching health care information believe they are using evidence-based sites and to understand their topics of interest, frequently navigated sites, and trust/confidence in the credibility of information found. Cross-sectional. Students at a private high school answered an anonymous survey inquiring about their belief that they were using evidence-based sites, topics of interest, search engines of choice, and their trust in information obtained. Descriptive statistics and multivariate analysis of variance were used to compare trends across grade levels. Of 705 students enrolled, 24.7% were absent or declined to participate. For the remaining students, 497 completed the surveys, representing a response rate of 70.5% (497/705) and a participation rate of 93.6% (497/531). Overall, 82% of students communicated that they believed they were using evidence-based sources when searching for health information (p information, and 43% investigated specific medical conditions; topics related to skin and acne were researched significantly more often (p information they learn from the Internet. We found it chilling that less than half of students obtained their information from a Web site with health care professionals' oversight.

  12. 2010 American Conference on Neutron Scattering (ACNS 2010)

    Energy Technology Data Exchange (ETDEWEB)

    Billinge, Simon

    2011-06-17

    The ACNS provides a focal point for the national neutron user community to strengthen ties within this diverse group, while at the same time promoting neutron research among colleagues in related disciplines identified as “would-be” neutron users. The American Conference on Neutron Scattering thus serves a dual role as a national user meeting and a scientific meeting. As a venue for scientific exchange, the ACNS showcases recent results and provides forums for scientific discussion of neutron research in diverse fields such as hard and soft condensed matter, liquids, biology, magnetism, engineering materials, chemical spectroscopy, crystal structure, and elementary excitations, fundamental physics and development of neutron instrumentation through a combination of invited talks, contributed talks and poster sessions. As a “super-user” meeting, the ACNS fulfills the main objectives of users' meetings previously held periodically at individual national neutron facilities, with the advantage of a larger and more diverse audience. To this end, each of the major national neutron facilities (NIST, LANSCE, HFIR and SNS) have an opportunity to exchange information and update users, and potential users, of their facility. This is also an appropriate forum for users to raise issues that relate to the facilities. For many of the national facilities, this super-user meeting should obviate the need for separate user meetings that tax the time, energy and budgets of facility staff and the users alike, at least in years when the ACNS is held. We rely upon strong participation from the national facilities. The NSSA intends that the American Conference on Neutron Scattering (ACNS) will occur approximately every two years, but not in years that coincide with the International or European Conferences on Neutron Scattering. The ACNS is to be held in association with one of the national neutron centers in a rotating sequence, with the host facility providing local

  13. Status of the AC perpendicular biased ferrite tuned cavity development program at TRIUMF

    International Nuclear Information System (INIS)

    Poirier, R.L.; Enchevich, I.B.

    1993-01-01

    The rf cavity for the Booster Synchrotron requires a frequency swing from 46 MHz to 61 MHz at a repetition rate of 50 Hz and a maximum accelerating voltage of 62,5 kV. These parameters have been achieved on a prototype cavity at TRIUMF using yttrium garnet ferrites rather than the conventional parallel biased NiZn ferrites. The results of the tests performed on the prototype cavity as well as some of the problems encountered and their solutions are reported. 4 refs.; 8 figs

  14. Changes in serum desnutrin levels in patients with acne vulgaris.

    Science.gov (United States)

    Demir, Betul; Ucak, Haydar; Cicek, Demet; Aydin, Suleyman; Erden, Ilker; Dertlioglu, Selma Bakar

    2014-01-01

    Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris. We investigated the association between serum desnutrin levels and acne vulgaris in the pathogenesis of insulin resistance. 25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Patients with acne vulgaris had a mean serum desnutrin level of (8.83 ± 1.13 μIU/mL), which was statistically significantly lower in the control group (10:58 ± 3.43 μIU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 ± 7:46 mg/dL, 11.33 ± 5.93 μIU/mL, 2.49 ± 1.40, respectively) were significantly higher than the control group (77.36 ± 9.83 mg/dL, 5.82 ± 2.68 μIU/mL, 1.11 ± 0.51, respectively) (p = 0.01, pacne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.

  15. Antibacterial activity of Thai herbal extracts on acne involved microorganism.

    Science.gov (United States)

    Niyomkam, P; Kaewbumrung, S; Kaewnpparat, S; Panichayupakaranant, P

    2010-04-01

    Ethyl acetate and methanol extracts of 18 Thai medicinal plants were investigated for their antibacterial activity against Propionibacterium acnes, Stapylococcus aureus, and S. epidermidis. Thirteen plant extracts were capable of inhibiting the growth of P. acnes and S. epidermidis, while 14 plant extracts exhibited an inhibitory effect on S. aureus. Based on the broth dilution method, the ethyl acetate extract of Alpinia galanga (L.) Wild. (Zingiberaceae) rhizome showed the strongest antibacterial effect against P. acnes, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 156.0 and 312.0 microg/mL, respectively. On the basis of bioassay-guided purification, the ethyl acetate extract was isolated to afford the antibacterial active compound, which was identified as 1'-acetoxychavicol acetate (1'-ACA). 1'-ACA had a strong inhibitory effect on P. acnes with MIC and MBC values of 62.0 and 250.0 microg/mL, respectively. Thus, 1'-ACA was used as an indicative marker for standardization of A. galanga extract using high performance liquid chromatography. These results suggest that A. galanga extract could be an interesting agent for further studies on an alternative treatment of acne.

  16. Acne Scar Treatment: A Multimodality Approach Tailored to Scar Type.

    Science.gov (United States)

    Zaleski-Larsen, Lisa A; Fabi, Sabrina G; McGraw, Timothy; Taylor, Mark

    2016-05-01

    Acne scarring can be classified into atrophic icepick, boxcar, and rolling scars in addition to keloidal and hypertrophic scars. Additionally, these scars can be erythematous, hyperpigmented, and/or hypopigmented. Each scar type has a different structural cause warranting a customized approach. Many cosmetic options exist to address these changes individually, but little literature exists about the safety and efficacy of combining such procedures and devices. A Medline search was performed on combination treatments because it relates to facial acne scarring, and results are summarized. Practical applications for these combinations of procedures are also discussed. Studies examining the efficacy and safety of ablative, nonablative, fractionated, and nonfractionated lasers, dermabrasion, chemical peels, needling, subcision, radiofrequency, stem cell therapy, fat transplantation, platelet-rich plasma, and hyaluronic acid dermal fillers for acne scars were found. The authors review their experience in combining these techniques. Review of the literature revealed multiple single options for facial acne scarring treatment with minimal evidence in the literature found on the safety and efficacy of combining such procedures and devices. The authors' experience is that combining acne scar treatment techniques can be performed safely and synergistically with optimal patient outcomes.

  17. Developments and directions in 200 MHz very high power RF at LAMPF

    International Nuclear Information System (INIS)

    Cliff, R.; Bush, E.D.; DeHaven, R.A.; Harris, H.W.; Parsons, M.

    1991-01-01

    The Los Alamos Meson Physics Facility (LAMPF), is a linear particle accelerator a half-mile long. It produces an 800 million electron- volt hydrogen-ion beam at an average current of more than one milliamp. The first RF section of the accelerator consists of four Alvarez drift-tube structures. Each of these structures is excited by an amplifier module at a frequency of 201.25 MHz. These amplifiers operate at a duty of 13 percent or more and at peak pulsed power levels of about 2.5 million watts. The second RF accelerator section consists of forty-four side-coupled-cavity structures. Each of these is excited by an amplifier module at a frequency of 805 MHz. These amplifiers operate at a duty of up to 12 percent and at peak pulsed power levels of about 1.2 million watts. The relatively high average beam current in the accelerator places a heavy demand upon components in the RF systems. The 201-MHz modules have always required a large share of maintenance efforts. In recent years, the four 201.25 MHz modules have been responsible for more than twice as much accelerator down-time as have the forty-four 805 MHz modules. This paper reviews recent, ongoing, and planned improvements in the 201-MHz systems. The Burle Industries 7835 super power triode is used in the final power amplifiers of each of the 201-MHz modules. This tube has been modified for operation at LAMPF by the addition of Penning ion vacuum''pumps.'' This has enabled more effective tube conditioning and restarting. A calorimetry system of high accuracy is in development to monitor tube plate-power dissipation

  18. Acne: a new model of immune-mediated chronic inflammatory skin disease.

    Science.gov (United States)

    Antiga, E; Verdelli, A; Bonciani, D; Bonciolini, V; Caproni, M; Fabbri, P

    2015-04-01

    Acne is a chronic inflammatory disease of the sebaceous-pilosebaceous unit. Interestingly, inflammation can be detected by histopathological examination and immuohistochemical analysis even in the apparently non-inflammatory acneic lesions, such as comedones. In the last years, it has been clearly demonstrated that acne development is linked to the combination of predisposing genetic factors and environmental triggers, among which a prominent role is played by the follicular colonization by Propionibacterium acnes (P. acnes). P. acnes displays several activities able to promote the development of acne skin lesions, including the promotion of follicular hyperkeratinisation, the induction of sebogenesis, and the stimulation of an inflammatory response by the secretion of proinflammatory molecules and by the activation of innate immunity, that is followed by a P. acnes-specific adaptive immune response. In addition, P. acnes-independent inflammation mediated by androgens or by a neurogenic activation, followed by the secretion in the skin of pro-inflammatory neuropeptides, can occur in acne lesions. In conclusion, acne can be considered as a model of immune-mediated chronic inflammatory skin disease, characterized by an innate immune response that is not able to control P. acnes followed by a Th1-mediated adaptive immune response, that becomes self-maintaining independently from P. acnes itself.

  19. Room temperature RF characterization of niobium SCRF cavities and their prototypes

    International Nuclear Information System (INIS)

    Mahawar, Ashish; Mohania, Praveen; Shrivastava, P.; Yadav, Anand; Puntambekar, A.M.

    2013-01-01

    Raja Ramanna Centre for Advanced Technology is working on development of 1.3 GHz and 650 MHz multi-cell SCRF cavities. The multi-cell cavities require RF characterization at various stages of fabrication to ensure that the final welded cavity has the right resonant frequency. The prototype cavities as well as the final cavities were extensively characterized at each stage of half cell, dumb bell and end group development and assembly stages. The paper will provide details of the RF characterizations done and the final results achieved. (author)

  20. Comparison of fractional microneedling radiofrequency and bipolar radiofrequency on acne and acne scar and investigation of mechanism: comparative randomized controlled clinical trial.

    Science.gov (United States)

    Min, Seonguk; Park, Seon Yong; Yoon, Ji Young; Suh, Dae Hun

    2015-12-01

    Fractional microneedling radiofrequency (FMR) is one of the promising methods in acne treatment. Moreover, bipolar radiofrequency (BR) generates heat thereby which induces neocollagenosis. FMR may have the potential to be a safe and effective treatment for the patients both with acne and acne scar. This study was performed to compare the efficacy and safety of FMR and BR in acne and acne scar treatment. Furthermore, mechanism of the FMR treatment was investigated through skin tissues obtained from subjects. Twenty subjects with mild-to-moderate acne and acne scars were treated in a split-face manner with FMR and BR. Two sessions of treatment was done 4 weeks apart in a total 12-week prospective single-blind, randomized clinical trial. Clinical assessment and sebum measurement were carried out for the evaluation of efficacy and safety. Skin tissues were acquired for investigation of molecular changes. FMR was more effective for acne scar especially in icepick and boxcar scar compared to BR. Both inflammatory and non-inflammatory acne lesions decreased by 80 and 65 % in the FMR-treated side at the final visit of 12 weeks, respectively. FMR treatment resulted in significant reduction of sebum excretion. Both treatments showed no severe adverse effects other than erythema. The FMR showed superior efficacy in acne and acne scar compared with BR. Increased expression of TGFβ and collagen I and decreased expression of NF-κB, IL-8 are suggested to involve in the improvement of acne scar and acne lesion by FMR.

  1. RF cavity for the Novosibirsk race-track microtron-recuperator

    International Nuclear Information System (INIS)

    Gavrilov, N.; Kuptsov, I.; Kurkin, G.; Mironenko, L.; Petrov, V.; Sedlyarov, I.; Veshcherevich, V.

    1994-01-01

    Geometry, engineering design and characteristics of a 181 MHz RF cavity are described. The cavity has copper clad stainless steel walls and has a Q of 42,000 and a shunt impedance of 8.5 MOhm. The cavities of that type are parts of an RF system of a CW race-track microtron-recuperator (RTMR). 10 refs.; 16 figs.; 1 tab

  2. RF Power Requirements for PEFP SRF Cavity Test

    International Nuclear Information System (INIS)

    Kim, Han Sung; Seol, Kyung Tae; Kwon, Hyeok Jung; Cho, Yong Sub

    2011-01-01

    For the future extension of the PEFP (Proton Engineering Frontier Project) Proton linac, preliminary study on the SRF (superconducting radio-frequency) cavity is going on including a five-cell prototype cavity development to confirm the design and fabrication procedures and to check the RF and mechanical properties of a low-beta elliptical cavity. The main parameters of the cavity are like followings. - Frequency: 700 MHz - Operating mode: TM010 pi mode - Cavity type: Elliptical - Geometrical beta: 0.42 - Number of cells: 5 - Accelerating gradient: 8 MV/m - Epeak/Eacc: 3.71 - Bpeak/Eacc: 7.47 mT/(MV/m) - R/Q: 102.3 ohm - Epeak: 29.68 MV/m (1.21 Kilp.) - Geometrical factor: 121.68 ohm - Cavity wall thickness: 4.3 mm - Stiffening structure: Double ring - Effective length: 0.45 m For the test of the cavity at low temperature of 4.2 K, many subsystems are required such as a cryogenic system, RF system, vacuum system and radiation shielding. RF power required to generate accelerating field inside cavity depends on the RF coupling parameters of the power coupler and quality factor of the SRF cavity and the quality factor itself is affected by several factors such as operating temperature, external magnetic field level and surface condition. Therefore, these factors should be considered to estimate the required RF power for the SRF cavity test

  3. Segmented trapped vortex cavity

    Science.gov (United States)

    Grammel, Jr., Leonard Paul (Inventor); Pennekamp, David Lance (Inventor); Winslow, Jr., Ralph Henry (Inventor)

    2010-01-01

    An annular trapped vortex cavity assembly segment comprising includes a cavity forward wall, a cavity aft wall, and a cavity radially outer wall there between defining a cavity segment therein. A cavity opening extends between the forward and aft walls at a radially inner end of the assembly segment. Radially spaced apart pluralities of air injection first and second holes extend through the forward and aft walls respectively. The segment may include first and second expansion joint features at distal first and second ends respectively of the segment. The segment may include a forward subcomponent including the cavity forward wall attached to an aft subcomponent including the cavity aft wall. The forward and aft subcomponents include forward and aft portions of the cavity radially outer wall respectively. A ring of the segments may be circumferentially disposed about an axis to form an annular segmented vortex cavity assembly.

  4. Yashada bhasma (Zinc calx) and Tankana (Borax) inhibit Propionibacterium acne and suppresses acne induced inflammation in vitro.

    Science.gov (United States)

    Sandeep Varma, R; Shamsia, S; Thiyagarajan, O S; Vidyashankar, S; Patki, P S

    2014-08-01

    Yashada bhasma (YB) and Tankana (TA) are well characterized minerals used in traditional medicine for the treatment of various skin ailments. Yashada bhasma and TA are a unique preparation of zinc and borax, respectively. The study was conducted to evaluate the in vitro inhibitory effect of YB, TA and its combination (YBTA) on Propionibacterium acne growth and P. acne-induced inflammation. The minerals were tested for anti-P. acne activity by disc diffusion and broth microdilution methods. The effect of these minerals on P. acne induced TNF-α and IL-8 production and gene expression were studied in THP-1 cells. In vitro toxicity was tested on human keratinocytes (HaCaT) and mouse embryonic fibroblasts (NIH3T3) using MTT assay. The minimum inhibitory concentrations (MIC values) for YB, TA and YBTA against P. acne were 0.1 ± 0.2, 1.9 ± 0.5 and 0.3 ± 0.5 mg mL(-1) , respectively. YB, TA and YBTA inhibited TNFα by 57.57%, 59.09% and 68.93% and IL-8 production by 48.76%, 47.92% and 51.13% in P. acne-stimulated THP-1 cells, respectively. The CTC50 values on HaCaT and NIH3T3 was 17.44 ± 0.5 and 16.37 ± 0.2 μg mL(-1) for YB, 1023.03 ± 4.0 and 1286.17 ± 4.4 μg mL(-1) for TA and 89.12 ± 2.3 and 111.58 ± 3.5 μg mL(-1) for YBTA, respectively. The present study revealed the inhibitory effect of YB, TA and YBTA on P. acne growth and inflammation. Clinical studies have suggested the anti-acne benefits of formulations containing YB and TA. The findings obtained from the present in vitro studies provide evidence to support the mechanism of anti-acne properties of YB and TA. © 2014 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  5. Profile of acne vulgaris-A hospital-based study from South India

    Directory of Open Access Journals (Sweden)

    Adityan Balaji

    2009-01-01

    Full Text Available Background: Acne vulgaris is believed to be the most common disease of the skin. There is no Indian study on the profile of acne vulgaris, markers of severe forms of acne vulgaris and a possible correlation between acne vulgaris and markers of androgenicity in females. Aim: To study the profile of acne vulgaris, its seasonal variation, relationship with smoking and possible correlation between acne vulgaris and markers of androgenicity in females. Methods: The study was conducted between August 2006 and June 2008. All patients with acne vulgaris who consented to participate in the study were included. The parameters evaluated included age, gender, age of onset, duration of lesions, site of lesions, grade, relation with menstrual cycle, markers of androgenicity, number of acne lesions such as comedones, papules pustules and nodules, number and site of post-acne scarring, post-acne hyperpigmentation, seasonal variation and history of smoking. Results: A total of 309 patients with acne vulgaris were included in the study. The frequency of acne vulgaris in our study was 1.068%. Mean age of the study group was 19.78 years. Male to female ratio was 1.25:1. The most common age group involved was 16 to 20 years (59.8%. Mean age of onset was 15.97 years. Face was involved in all the patients, followed by back (28.2%, chest (20.1%, neck (9.4% and arms (10%. In the older age groups, women were more likely to report having acne vulgaris than men ( P = 0.01. The closed comedones outnumbered open comedones by a factor of 4.9:1. A total of 186 patients (60.2% had grade 1 acne vulgaris, 85 (27.5% had grade 2 acne, 8 (2.6% had grade 3 acne and 30 (9.7% had grade 4 acne vulgaris. There was a higher incidence of scarring (39.5% and post-acne hyperpigmentation (24.6% in our study. In female patients, 57.7% had premenstrual flare and 12.4% had cutaneous markers of androgenicity. There was no association between severity of acne vulgaris and other markers of

  6. Experience use of azelaic acid in patients with acne

    Directory of Open Access Journals (Sweden)

    A. V. Statsenco

    2014-01-01

    Full Text Available Treatment of acne is one of the important problems of modern dermatology. The goal of the research. The study of clinical efficacy and safety of the 15% azelaic acid in the form of Azelik-gel in the treatment of patients with papulo-pustular acne, mild to moderate in severity. Material and methods. Open comparative study of 8 weeks, which was attended by 75 patients. To assess the safety and efficacy of the therapy was performed clinical and biochemical blood and urine tests, evaluation of dermatological status, measurement of pH, moisture and oiliness of skin and analysis of DLQI. Results. 82% of patients receiving the Azelik-gel, marked clinical improvement or significant improvement. Conclusions. The results of the study indicate a high level of safety and tolerability of the Azelik-gel and obtained clinical results have shown its therapeutic efficacy in the treatment of papulo-pustular acne mild to moderate in severity.

  7. Development of superconducting crossbar-H-mode cavities for proton and ion accelerators

    Directory of Open Access Journals (Sweden)

    F. Dziuba

    2010-04-01

    Full Text Available The crossbar-H-mode (CH structure is the first superconducting multicell drift tube cavity for the low and medium energy range operated in the H_{21} mode. Because of the large energy gain per cavity, which leads to high real estate gradients, it is an excellent candidate for the efficient acceleration in high power proton and ion accelerators with fixed velocity profile. A prototype cavity has been developed and tested successfully with a gradient of 7  MV/m. A few new superconducting CH cavities with improved geometries for different high power applications are under development at present. One cavity (f=325  MHz, β=0.16, seven cells is currently under construction and studied with respect to a possible upgrade option for the GSI UNILAC. Another cavity (f=217  MHz, β=0.059, 15 cells is designed for a cw operated energy variable heavy ion linac application. Furthermore, the EUROTRANS project (European research program for the transmutation of high level nuclear waste in an accelerator driven system, 600 MeV protons, 352 MHz is one of many possible applications for this kind of superconducting rf cavity. In this context a layout of the 17 MeV EUROTRANS injector containing four superconducting CH cavities was proposed by the Institute for Applied Physics (IAP Frankfurt. The status of the cavity development related to the EUROTRANS injector is presented.

  8. Experimental Study of an 805 MHz Cryomodule for the Rare Isotope Accelerator

    CERN Document Server

    Grimm, T L; Compton, C; Hartung, W; Johnson, M; Marti, F; Popielarski, J; York, R C

    2004-01-01

    The Rare Isotope Accelerator (RIA) driver linac will use superconducting, 805 MHz, 6-cell elliptical cavities with geometric β values of 0.47, 0.61 and 0.81. Each elliptical cavity cryomodule will have four cavities [1]. Room temperature sections between each cryomodule will consist of quadrupole doublets, beam instrumentation, and vacuum systems. Michigan State University (MSU) has designed a compact cryostat that reduces the tunnel cross-section and improves the linac real estate gradient. The cold mass alignment is accomplished with a titanium rail system supported by adjustable nitronic links from the top vacuum plate, and is similar to that used for existing MSU magnet designs. The same concept has also been designed to accommodate the quarter-wave and half-wave resonators with superconducting solenoids used at lower velocity in RIA. Construction of a prototype β=0.47 cryomodule was completed in February 2004 and is presently under test in realistic operating conditions. Experimental ...

  9. IL-17/Th17 Pathway Is Activated in Acne Lesions

    Science.gov (United States)

    Kelhälä, Hanna-Leena; Palatsi, Riitta; Fyhrquist, Nanna; Lehtimäki, Sari; Väyrynen, Juha P.; Kallioinen, Matti; Kubin, Minna E.; Greco, Dario; Tasanen, Kaisa; Alenius, Harri; Bertino, Beatrice; Carlavan, Isabelle; Mehul, Bruno; Déret, Sophie; Reiniche, Pascale; Martel, Philippe; Marty, Carine; Blume-Peytavi, Ulrike; Voegel, Johannes J.; Lauerma, Antti

    2014-01-01

    The mechanisms of inflammation in acne are currently subject of intense investigation. This study focused on the activation of adaptive and innate immunity in clinically early visible inflamed acne lesions and was performed in two independent patient populations. Biopsies were collected from lesional and non-lesional skin of acne patients. Using Affymetrix Genechips, we observed significant elevation of the signature cytokines of the Th17 lineage in acne lesions compared to non-lesional skin. The increased expression of IL-17 was confirmed at the RNA and also protein level with real-time PCR (RT-PCR) and Luminex technology. Cytokines involved in Th17 lineage differentiation (IL-1β, IL-6, TGF-β, IL23p19) were remarkably induced at the RNA level. In addition, proinflammatory cytokines and chemokines (TNF-α, IL-8, CSF2 and CCL20), Th1 markers (IL12p40, CXCR3, T-bet, IFN-γ), T regulatory cell markers (Foxp3, IL-10, TGF-β) and IL-17 related antimicrobial peptides (S100A7, S100A9, lipocalin, hBD2, hBD3, hCAP18) were induced. Importantly, immunohistochemistry revealed significantly increased numbers of IL-17A positive T cells and CD83 dendritic cells in the acne lesions. In summary our results demonstrate the presence of IL-17A positive T cells and the activation of Th17-related cytokines in acne lesions, indicating that the Th17 pathway is activated and may play a pivotal role in the disease process, possibly offering new targets of therapy. PMID:25153527

  10. RF cavities for the positron accumulator ring (PAR) of the Advanced Photon Source (APS)

    International Nuclear Information System (INIS)

    Kang, Y.W.; Nassiri, A.; Bridges, J.F.; Smith, T.L.; Song, J.J.

    1995-01-01

    The cavities for the dual frequency system of the APS PAR are described. The system uses two frequencies: a 9.78MHz fundamental system for the particle accumulation and a 117.3MHz twelfth harmonic system for the bunch compression. The cavities have been built, installed, tested, and used for storing the beam in the PAR for about a year. The fundamental cavity is a reentrant coaxial type with a capacitive loading plunger and has 1.6m length. The harmonic cavity is a symmetrical reentrant coaxial type and is 0.8m long. Ferrite tuners are used for frequency tuning. During the accumulation period, the ferrite tuner of the harmonic cavity works as a damper to disable the cavity. During an injection cycle the 9.78MHz system accumulates 24 positron bunches in a bucket and the 117.3MHz system compresses the bunch into a shorter bunch. Measurements were made on the rf properties of the cavities

  11. [Use of cyproterone acetate in the treatment of acne].

    Science.gov (United States)

    Piquero Martín, J; Acosta, H

    1982-01-01

    Forty two female patients with strong acne and oiliness were studied all of them were treated with a tablet daily of 2 mg. of cyprosterone Acetate and 0.05 mg of ethinyl oestradiol for 3 weeks and a week without it. We found intolerance to the treatment in 9 out of 42 patients and a high percentage of cure or marked improvement in 96.9% of patients. In conclusion this drug is a good help to the treatment of female acne with seborrheic skin.

  12. Experience use of azelaic acid in patients with acne

    OpenAIRE

    A. V. Statsenco; U. G. Gorbunov; V. R. Khairutdinov; N. E. Shestopalov; O. V. Antonova

    2014-01-01

    Treatment of acne is one of the important problems of modern dermatology. The goal of the research. The study of clinical efficacy and safety of the 15% azelaic acid in the form of Azelik-gel in the treatment of patients with papulo-pustular acne, mild to moderate in severity. Material and methods. Open comparative study of 8 weeks, which was attended by 75 patients. To assess the safety and efficacy of the therapy was performed clinical and biochemical blood and urine tests, evaluation of de...

  13. Heritability and GWAS Analyses of Acne in Australian Adolescent Twins.

    Science.gov (United States)

    Mina-Vargas, Angela; Colodro-Conde, Lucía; Grasby, Katrina; Zhu, Gu; Gordon, Scott; Medland, Sarah E; Martin, Nicholas G

    2017-12-01

    Acne vulgaris is a skin disease with a multifactorial and complex pathology. While several twin studies have estimated that acne has a heritability of up to 80%, the genomic elements responsible for the origin and pathology of acne are still undiscovered. Here we performed a twin-based structural equation model, using available data on acne severity for an Australian sample of 4,491 twins and their siblings aged from 10 to 24. This study extends by a factor of 3 an earlier analysis of the genetic factors of acne. Acne severity was rated by nurses on a 4-point scale (1 = absent to 4 = severe) on up to three body sites (face, back, chest) and on up to three occasions (age 12, 14, and 16). The phenotype that we analyzed was the most severe rating at any site or age. The polychoric correlation for monozygotic twins was higher (r MZ = 0.86, 95% CI [0.81, 0.90]) than for dizygotic twins (r DZ = 0.42, 95% CI [0.35, 0.47]). A model that includes additive genetic effects and unique environmental effects was the most parsimonious model to explain the genetic variance of acne severity, and the estimated heritability was 0.85 (95% CI [0.82, 0.87]). We then conducted a genome-wide analysis including an additional 271 siblings - for a total of 4,762 individuals. A genome-wide association study (GWAS) scan did not detect loci associated with the severity of acne at the threshold of 5E-08 but suggestive association was found for three SNPs: rs10515088 locus 5q13.1 (p = 3.9E-07), rs12738078 locus 1p35.5 (p = 6.7E-07), and rs117943429 locus 18q21.2 (p = 9.1E-07). The 5q13.1 locus is close to PIK3R1, a gene that has a potential regulatory effect on sebocyte differentiation.

  14. Guidelines of care for the management of acne vulgaris.

    Science.gov (United States)

    Zaenglein, Andrea L; Pathy, Arun L; Schlosser, Bethanee J; Alikhan, Ali; Baldwin, Hilary E; Berson, Diane S; Bowe, Whitney P; Graber, Emmy M; Harper, Julie C; Kang, Sewon; Keri, Jonette E; Leyden, James J; Reynolds, Rachel V; Silverberg, Nanette B; Stein Gold, Linda F; Tollefson, Megha M; Weiss, Jonathan S; Dolan, Nancy C; Sagan, Andrew A; Stern, Mackenzie; Boyer, Kevin M; Bhushan, Reva

    2016-05-01

    Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon in adults and can also be seen in children. This evidence-based guideline addresses important clinical questions that arise in its management. Issues from grading of acne to the topical and systemic management of the disease are reviewed. Suggestions on use are provided based on available evidence. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  15. The epidemiology of acne vulgaris in late adolescence

    Directory of Open Access Journals (Sweden)

    Lynn DD

    2016-01-01

    Full Text Available Darren D Lynn,1 Tamara Umari,1 Cory A Dunnick,2,3 Robert P Dellavalle2–4 1Department of Dermatology, University of Colorado School of Medicine, 2Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, 3Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, 4Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Importance: Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15–19-year olds remains lacking. Objective: To assess the global burden of the disease associated with acne vulgaris for late adolescents (15–19-year olds and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Design: Database summary study. Setting: Global Burden of Disease Study 2010 database. Participants: Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Main outcomes and measures: Geographic region-level disability-adjusted life year rates (per 100,000 persons associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Conclusion and relevance: Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous

  16. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

    Directory of Open Access Journals (Sweden)

    Melnik BC

    2015-07-01

    Full Text Available Bodo C Melnik Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Germany Abstract: Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1 hyperglycemic carbohydrates, 2 milk and dairy products, 3 saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs. Diet-induced insulin/insulin-like growth factor (IGF-1-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis. Western diet provides abundant branched-chain amino acids (BCAAs, glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1. Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1, the key regulator of anabolism and lipogenesis. FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ, liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c, crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARγ and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Δ6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides. Diet-mediated aberrations in sebum quantity (hyperseborrhea and composition (dysseborrhea promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate. Free palmitate functions as a “danger signal,” stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1β release, Th17 differentiation, and interleukin-17-mediated keratinocyte

  17. New Control Structure of the 10 MHz RF System in the CERN PS

    CERN Document Server

    Damerau, H

    2013-01-01

    The 10MHz cavities comprise the main RF system in the CERN PS and the only one that allows acceleration. In total 11 tunable cavities (10 operational and a hot spare, grouped into 3+1 tuning groups and up to presently 6 voltage program groups) are distributed all around the circumference of the PS ring. Next to the RF drive signal each of the cavities is controlled by a voltage program and timing pulses to open and close the relays to short-circuit the cavity gaps. These control signals are presently generated by a dedicated hardware matrix. It translates voltage functions and relay timing pulses per cavity group into functions and timings per cavity. However, due to its central position in the RF beam control system, the dedicated hardware matrix can cause significant downtime in case of a major hardware failure. Instead of upgrading the existing obsolete hardware, this note suggests a replacement by standard controls hardware and dedicated application software. Thanks to advanced software concepts like “M...

  18. [Clinical trials in dermatology. Evaluation of the tolerability and efficacy of a topical anti-acne].

    Science.gov (United States)

    Verschoore, M; Poncet, M; Schaefer, H; Revuz, J; De Prost, Y; Guillaume, J C; Ortonne, J P; Czernielewski, J

    1991-01-01

    Acne is a frequent dermatologic disease of the teenagers. Methodology of antiacne preparations clinical trials has evolved recently, leading to better comprehension of acne treatment on acne lesions. The main rules for good clinical evaluation of acne treatments are: an objective counting of each individual lesions on a defined area (face, back), a global acne assessment, a therapy duration from 1 to 3 months or more, a skin safety evaluation for erythema, desquamation, dryness, itching, burning and oiliness with a 0 to 3 scoring system.

  19. Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil*

    Science.gov (United States)

    Bagatin, Ediléia; Timpano, Denise Lourenço; Guadanhim, Lilia Ramos dos Santos; Nogueira, Vanessa Mussupapo Andraus; Terzian, Luiz Roberto; Steiner, Denise; Florez, Mercedes

    2014-01-01

    BACKGROUND Acne is a common disease in adolescents, but there are no epidemiological data for acne in Brazil. OBJECTIVES To estimate the prevalence and degree of acne in adolescents from Sao Paulo and study socio-demographic factors, family history and lifestyle, associated with the disease. METHODS Cross-sectional study with 452 adolescents aged between 10 and 17 (mean=13.3 years), students from elementary and high school, examined by 3 independent evaluators. RESULTS 62.4% were female, 85.8% white and 6.4% were aged 14. The prevalence was 96.0% and increased with age - all students over 14 had acne. The most prevalent form of acne was comedonal (61.1%), followed by mild (30.6%) and moderate (7.6%) papular-pustular, which affected mostly the face (97.5%). About half of the adolescents reported family history for acne in mother or father, and 20.6% reported previous treatment for acne. There was a higher chance of presenting non-comedonal acne with increased age (pacne in adolescents varies widely due to the clinical features and diagnostic methods used. Adolescents whose brothers/sisters had acne (OR=1.7-p=0.027) and those over 13 (OR=8.3-pacne. CONCLUSION This study showed high prevalence of acne in adolescents from Sao Paulo, predominantly the comedonal form on the face, with a higher chance of presenting non-comedonal acne with increased age. PMID:24937816

  20. Development of an advanced electropolishing setup for multicell high gradient niobium cavities

    Directory of Open Access Journals (Sweden)

    F. Éozénou

    2012-08-01

    Full Text Available Reproducible operation at high performances of superconducting cavities is required for linear accelerators. High beta elliptical cavities are thus of concern and, to achieve required performances for such resonators, surface preparation including electropolishing is recommended. We have designed and operate a setup for electropolishing in the vertical position of multicell cavities in order to: (i obtain high yield with large elliptical cavities for Superconducting Linac (SPL or European Spallation Source projects; (ii develop a reference installation demonstrating that this process is appropriate for the large scale treatment of cavities in industry. The setup described here is the first one able to electropolish vertically multicell cavities with circulating acid and high safety standards. This equipment makes it possible to use a wide range of parameters such as voltage, acid flow rate, temperature, and nitrogen injection with an R&D purpose in mind. Optimization is studied using modeling with COMSOL software for different cavities. As examples, we present some results for the 704 MHz high-beta SPL cavity and the 1300 MHz International Linear Collider cavity and show the influence of cathode shape on both acid flow and electric field distribution during the process. Importance of the size of the cavity and first results achieved on single-cell and nine-cell cavities will be discussed.

  1. Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk.

    Science.gov (United States)

    Shu, M; Kuo, S; Wang, Y; Jiang, Y; Liu, Y-T; Gallo, R L; Huang, C-M

    2013-01-01

    Propionibacterium acnes (P. acnes), a Gram-positive anaerobic bacterium, is a commensal organism in human skin. Like human cells, the bacteria produce porphyrins, which exhibit fluorescence properties and make bacteria visible with a Wood's lamp. In this review, we compare the porphyrin biosynthesis in humans and P. acnes. Also, since P. acnes living on the surface of skin receive the same radiation exposure as humans, we envision that the changes in porphyrin profiles (the absorption spectra and/or metabolism) of P. acnes by radiation may mirror the response of human cells to radiation. The porphyrin profiles of P. acnes may be a more accurate reflection of radiation risk to the patient than other biodosimeters/biomarkers such as gene up-/down-regulation, which may be non-specific due to patient related factors such as autoimmune diseases. Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk.

  2. BLAZAR SPECTRAL PROPERTIES AT 74 MHz

    Energy Technology Data Exchange (ETDEWEB)

    Massaro, F.; Funk, S. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Giroletti, M. [INAF Istituto di Radioastronomia, via Gobetti 101, I-40129 Bologna (Italy); Paggi, A.; D' Abrusco, R. [Harvard-Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Tosti, G. [Dipartimento di Fisica, Università degli Studi di Perugia, I-06123 Perugia (Italy)

    2013-10-01

    Blazars are the most extreme class of active galactic nuclei. Despite a previous investigation at 102 MHz for a small sample of BL Lac objects and our recent analysis of blazars detected in the Westerbork Northern Sky Survey, a systematic study of the blazar spectral properties at frequencies below 100 MHz has been never carried out. In this paper, we present the first analysis of the radio spectral behavior of blazars based on the recent Very Large Array Low-frequency Sky Survey (VLSS) at 74 MHz. We search for blazar counterparts in the VLSS catalog, confirming that they are detected at 74 MHz. We then show that blazars present radio-flat spectra (i.e., radio spectral indices of ∼0.5) when evaluated, which also about an order of magnitude in frequency lower than previous analyses. Finally, we discuss the implications of our findings in the context of the blazars-radio galaxies connection since the low-frequency radio data provide a new diagnostic tool to verify the expectations of the unification scenario for radio-loud active galaxies.

  3. Auto-tuning systems for J-PARC LINAC RF cavities

    International Nuclear Information System (INIS)

    Fang, Z.; Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S.; Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E.

    2014-01-01

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  4. Auto-tuning systems for J-PARC LINAC RF cavities

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Z., E-mail: fang@post.kek.jp [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E. [Japan Atomic Energy Agency (JAEA), 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195 (Japan)

    2014-12-11

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  5. High field conditioning of cryogenic RF cavities

    International Nuclear Information System (INIS)

    Cole, M.; Debiak, T.; Lom, C.; Shephard, W.; Sredniawski, J.

    1993-01-01

    Space-based and other related accelerators have conditioning and operation requirements that are not found in most machines. The use of cryogenic copper, relatively poor vacuum, and limited power storage and operating time put unusual demands on the high-field conditioning process and present some concerns. Two CW cryogenic engineering model open-quotes sparkerclose quotes cavities have been fabricated and tested to fairly high field levels. Tests included initial and repeated conditioning as well as sustained RF operations. The two cavities were an engineering model TDL and an engineering model RFQ. Both cavities operated at 425 MHz. The DTL was conditioned to 46 MV/m at 100% duty factor (CW) at cryogenic temperature. This corresponds to a gap voltage of 433 kV and a real estate accelerating gradient (energy gain/total cavity length) of 6.97 MV/m. The authors believe this to be record performance for cryo CW operation. During cryo pulsed operation, the same cavity reached 48 MV/m with 200 μsec pulses at 0.5% DF. The RFQ was conditioned to 30 MV/m CW at cryo, 85 kV gap voltage. During a brief period of cryo pulsed operation, the RFQ operated at 46 MV/m, or 125 kV gap voltage. Reconditioning experiments were performed on both cavities and no problems were encountered. It should be noted that the vacuum levels were not very stringent during these tests and no special cleanliness or handling procedures were followed. The results of these tests indicate that cavities can run CW without difficulty at cryogenic temperatures at normal conservative field levels. Higher field operation may well be possible, and if better vacuums are used and more attention is paid to cleanliness, much higher fields may be attainable

  6. Gallium-67-citrate uptake in a case of acne vulgaris

    International Nuclear Information System (INIS)

    Kipper, M.S.; Taylor, A.; Ashburn, W.L.

    1981-01-01

    A case of increased Ga-67 uptake in a patient with active acne vulgaris is reported. The scan was requested in a search for metastatic testicular carcinoma or bleomycin pulmonary toxicity. Careful clinical evaluation including physical examination was necessary in order to avoid an erroneous scan interpretation

  7. The oral adverse effects of isotretinoin treatment in acne vulgaris ...

    African Journals Online (AJOL)

    Background: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment. Objectives: This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in ...

  8. Lactic acid peeling in superficial acne scarring in Indian skin.

    Science.gov (United States)

    Sachdeva, Silonie

    2010-09-01

    Chemical peeling with both alpha and beta hydroxy acids has been used to improve acne scarring with pigmentation. Lactic acid, a mild alpha hydroxy acid, has been used in the treatment of various dermatological indications but no study is reported in acne scarring with pigmentation. To evaluate the efficacy and safety of full strength pure lactic acid 92% (pH 2.0) chemical peel in superficial acne scarring in Indian skin. Seven patients, Fitzpatrick skin type IV-V, in age group 20-30 years with superficial acne scarring were enrolled in the study. Chemical peeling was done with lactic acid at an interval of 2 weeks to a maximum of four peels. Pre- and post-peel clinical photographs were taken at every session. Patients were followed every month for 3 months after the last peel to evaluate the effects. At the end of 3 months, there was definite improvement in the texture, pigmentation, and appearance of the treated skin, with lightening of scars. Significant improvement (greater than 75% clearance of lesions) occurred in one patient (14.28%), good improvement (51-75% clearance) in three patients (42.84%), moderate improvement (26-50% clearance) in two patients (28.57%), and mild improvement (1-25% clearance) in one patient (14.28%). © 2010 Wiley Periodicals, Inc.

  9. Performance of the AC perpendicular biased ferrite tuned cavity for the TRIUMF KAON factory booster synchrotron

    International Nuclear Information System (INIS)

    Poirier, R.L.; Enchevich, I.B.; Mitra, A.K.; Fong, K.; Blaker, G.C.; Fang, S.

    1992-11-01

    The rf cavity for the Booster Synchrotron requires a frequency swing from 46 Mhz to 61 Mhz at a repetition rate of 50 Hz and a maximum accelerating voltage of 62.5 kV. These requirements were achieved on the prototype ferrite tuned cavity[1] for a short period of time and without any fast rf feedback or cavity tuning loops. Initially fast rf feedback and cavity tuning loops were closed at fixed frequencies (ferrite tuner dc biased ) to measure some of the response characteristics of the amplifier-cavity chain. Then a major effort was put into measuring the bandwidth response of the tuner in order to design the rf control loops for ac bias operation at 50 Hz. The performance of these control loops and results from long term running of the rf system are reported. (author) 3 refs., 5 figs

  10. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

    Science.gov (United States)

    Melnik, Bodo C

    2015-01-01

    Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs). Diet-induced insulin/insulin-like growth factor (IGF-1)-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis. Western diet provides abundant branched-chain amino acids (BCAAs), glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1). Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the key regulator of anabolism and lipogenesis. FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c), crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARγ and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Δ6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides. Diet-mediated aberrations in sebum quantity (hyperseborrhea) and composition (dysseborrhea) promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate. Free palmitate functions as a “danger signal,” stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1β release, Th17 differentiation, and interleukin-17-mediated keratinocyte proliferation. Oleate stimulates P. acnes adhesion, keratinocyte proliferation, and comedogenesis via interleukin-1α release. Thus, diet

  11. A New RF System for the CEBAF Normal Conducting Cavities

    International Nuclear Information System (INIS)

    Curt Hovater; Hai Dong; Alicia Hofler; George Lahti; John Musson; Tomasz Plawski

    2004-01-01

    The CEBAF Accelerator at Jefferson Lab is a 6 GeV five pass electron accelerator consisting of two superconducting linacs joined by independent magnetic transport arcs. CEBAF also has numerous normal conducting cavities for beam conditioning in the injector and for RF extraction to the experimental halls. The RF systems that presently control these cavities are becoming expensive to maintain, therefore a replacement RF control system is now being developed. For the new RF system, cavity field control is maintained digitally using an FPGA which contains the feedback algorithm. The system incorporates digital down conversion, using quadrature under-sampling at an IF frequency of 70 MHz. The VXI bus-crate was chosen as the operating platform because of its excellent RFI/EMI properties and its compatibility with the EPICS control system. The normal conducting cavities operate at both the 1497 MHz accelerating frequency and the sub-harmonic frequency of 499 MHz. To accommodate this, the ne w design will use different receiver-transmitter daughter cards for each frequency. This paper discusses the development of the new RF system and reports on initial results

  12. Adult-onset acne: prevalence, impact, and management challenges

    Directory of Open Access Journals (Sweden)

    Rocha MA

    2018-02-01

    Full Text Available Marco A Rocha, Ediléia Bagatin Paulista Medical School, Universidade Federal de São Paulo (Federal University of São Paulo, São Paulo, SP, Brazil Abstract: Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. In contrast to what was initially thought, most of these patients do not present endocrinopathy capable of leading to the development of the lesions. When present, polycystic ovarian syndrome is the main cause. However, in these cases, acne is rarely the only dermatological manifestation; hirsutism and acanthosis nigricans are often present. The majority of the normoandrogenic acne patients present a history since adolescence, but in many cases the lesion distribution and intensity change with time. There is often a typical localization of the lesions in the lower third of the face and lateral region of the neck. Another interesting feature is related to the impact on quality of life (QoL, which is always intense. Often there are signs of depression, even when the lesions are mild. As most adult patients are women, in addition to the conventional options, there is also hormone treatment. Combined oral contraceptives and spironolactone are good options. Knowing more about the particularities in etiopathogenesis, impact on QoL, and specific treatment options is important to all dermatologists who face the challenge of treating acne in adults. Keywords: adult, acne, hormonal, female

  13. The Incidence of Propionibacterium acnes in Shoulder Arthroscopy.

    Science.gov (United States)

    Chuang, Michael J; Jancosko, Jason J; Mendoza, Vivian; Nottage, Wesley M

    2015-09-01

    To document the skin colonization and deep tissue inoculation rates associated with arthroscopic shoulder surgery and how these rates differ with procedural and demographic factors. We prospectively recruited outpatient shoulder arthroscopy patients who agreed to participate and met the inclusion criteria from February 2013 to May 2014. All patients received routine antibiotic prophylaxis intravenously. Initial cultures were obtained before the skin preparation by swabbing the skin at the 3 standard portal sites: posterior, anterosuperior, and anterolateral. The skin preparation used 4% chlorhexidine scrub and 2% chlorhexidine gluconate/70% isopropyl alcohol paint applied to the entire shoulder. After completion of the arthroscopic procedure, a second culture was obtained through a cannula at the surgical site. All cultures were plated for 21 days using Brucella medium. We enrolled 51 patients over a 15-month period. Cultures showed a 72.5% Propionibacterium acnes superficial colonization rate: 46.1% of female and 81.6% of male patients (P = .027). We identified a deep culture-positive inoculation rate of 19.6%, all with positive P acnes skin colonization. No correlation could be made concerning diagnosis, procedure, suture anchor use, age, or sex. The rate of skin colonization with P acnes is high at arthroscopic portals, especially in men. Despite standard skin preparation and prophylactic antibiotics, the rate of deep tissue inoculation with P acnes in shoulder arthroscopy is much higher than the rate of infection reported in the literature. Shoulder arthroscopy introduces a significant amount of P acnes into the deep tissues. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  14. Improved reactor cavity

    International Nuclear Information System (INIS)

    Katz, L.R.; Demarchais, W.E.

    1984-01-01

    A reactor pressure vessel disposed in a cavity has coolant inlet or outlet pipes extending through passages in the cavity walls and welded to pressure nozzles. The cavity wall has means for directing fluid away from a break at a weld away from the pressure vessel, and means for inhibiting flow of fluid toward the vessel. (author)

  15. Prototype rf cavity for the HISTRAP accelerator

    International Nuclear Information System (INIS)

    Mosko, S.W.; Dowling, D.T.; Olsen, D.K.

    1989-01-01

    HISTRAP, a proposed synchrotron-cooling-storage ring designed to both accelerate and decelerate very highly charged very heavy ions for atomic physics research, requires an rf accelerating system to provide /+-/2.5 kV of peak accelerating voltage per turn while tuning through a 13.5:1 frequency range in a fraction of a second. A prototype half-wave, single gap rf cavity with biased ferrite tuning was built and tested over a continuous tuning range of 200 kHz through 2.7 MHz. Initial test results establish the feasibility of using ferrite tuning at the required rf power levels. The resonant system is located entirely outside of the accelerator's 15cm ID beam line vacuum enclosure except for a single rf window which serves as an accelerating gap. Physical separation of the cavity and the beam line permits in situ vacuum baking of the beam line at 300/degree/C

  16. Evaluation of Adolescents Diagnosed with Acne Vulgaris for Quality of Life and Psychosocial Challenges

    Science.gov (United States)

    Eyüboglu, Murat; Kalay, Incilay; Eyüboglu, Damla

    2018-01-01

    Background: Acne vulgaris is a common skin condition which affects most adolescents. It has a major impact on quality of life and psychosocial well-being. Aims: The aims of the study were to examine the psychosocial effects of acne on adolescents and changes in quality of life, and to reveal any difference in the possible effect between genders. In addition, an investigation of the association between acne severity and quality of life as well as psychosocial stress was conducted. Materials and Methods: The present study included 164 adolescents with a mean age of 12–18 years and was diagnosed with acne vulgaris without any previous treatment. The control group consisted of 188 healthy volunteers. Acne severity was evaluated by the global acne grading system. All patients filled in a Children's Dermatology Life Quality Index, Pediatric Quality of Life Questionnaire (PedsQL), and a Strength and Difficulties Questionnaire (SDQ). Results: The scores of SDQ and PedsQL were significantly lower in the case group. There was no significant correlation found between the genders in the control group for acne severity and scale scores. No significant correlation was found between acne severity and psychosocial challenges. Conclusions: The results of the present study show that acne has a significant effect on quality of life for adolescents, and this has an impact on their psychosocial life. Another important finding of the present study is that worsening in quality of life is not affected by some factors such as duration, severity of acne and age. PMID:29692454

  17. Vitamin D levels in acne vulgaris patients treated with oral isotretinoin.

    Science.gov (United States)

    El-Hamd, Mohammed Abu; El Taieb, Moustafa A; Ibrahim, Hassan M; Aly, Sanaa S

    2018-02-20

    Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. This study aimed to assess serum levels of 25 hydroxy vitamin D in patients with acne vulgaris before and after treatment with isotretinoin and its relation with acne vulgaris severity. Ninety patients with acne vulgaris and 60 age-sex matched healthy subject as controls have been recruited in this study. Patients were treated with 0.75 mg/kg/d isotretinoin for 3 months. Serum level of 25 hydroxy vitamin D has been measured at baseline and after treatment. Serum levels of 25 hydroxy vitamin D were significantly higher in patients with acne vulgaris than healthy controls (P = .001). There was a significant inverse relation between level of 25 hydroxy vitamin D and severity of acne vulgaris before treatment (P = .001). Serum levels of 25 hydroxy vitamin D were significantly increased after isotretinoin treatment in patients with acne vulgaris (P = .001). This study concluded that vitamin D may play a potential role in pathogenesis of acne vulgaris or acne vulgaris may have a negative effect on vitamin D synthesis. Further studies are needed to confirm these potential relations. © 2018 Wiley Periodicals, Inc.

  18. Assessment of Life Quality Index Among Patients with Acne Vulgaris in a Suburban Population.

    Science.gov (United States)

    Hazarika, Neirita; Rajaprabha, Radha K

    2016-01-01

    Acne vulgaris affects about 85% of adolescents, often extending into adulthood. Psychosocial impact of acne on health-related quality of life (QoL) has been identified, but it remains under-evaluated, especially in Indian patients. This study was aimed to assess the impact of acne and its sequelae on the QoL. This was a hospital-based, prospective, cross-sectional study done between June and November 2014 on 114 consenting patients above 15 years of age with acne vulgaris. Acne vulgaris and its sequelae were graded, and QoL was assessed by using Dermatology Life Quality Index (DLQI) questionnaire. Most cases (64%) were between 15 and 20 years. Females (57%) outnumbered males. Facial lesions (61.4%) and grade II acne were most common. Mean DLQI score was 7.22. DLQI scores were statistically influenced by the age of the patient, duration and grade of acne, acne scar, and postacne hyperpigmentation. This study showed significant impairment of QoL in acne patients. Assurance and counseling along with early treatment of acne vulgaris are important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.

  19. Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis.

    Science.gov (United States)

    Kang, Mi-Sun; Oh, Jong-Suk; Lee, Seok-Woo; Lim, Hoi-Soon; Choi, Nam-Ki; Kim, Seon-Mi

    2012-02-01

    While it is generally accepted that Propionibacterium acnes is involved in the development of acne, other bacteria including Staphylococcus epidermidis have also been isolated from the acne lesion. The interaction between Lactobacillus reuteri, a probiotic bacterium, and acnegenic bacteria is unclear. This study examined the effects of L. reuteri on the proliferation of P. acnes and S. epidermidis. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of P. acnes and S. epidermidis. The proliferation of P. acnes was decreased by 2-log scales after incubation with L. reuteri for 24 h. In addition, the proliferation of S. epidermidis was decreased by 3-log scales after incubation with L. reuteri for 24 h, whereas the growth of L. reuteri was unaffected by P. acnes or S. epidermidis. Among the L. reuteri strains examined, L. reuteri KCTC 3679 had the strongest inhibitory effect on the growth of P. acnes and S. epidermidis, followed by L. reuteri KCTC 3594 and L. reuteri KCTC 3678. Interestingly, reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. The most pronounced the antibacterial activities of L. reuteri were attributed to the production of organic acids. Overall, these results suggest that L. reuteri may be a useful probiotic agent to control the growth of bacteria involved in acne inflammation and prevent acne.

  20. Evaluation of social anxiety, self-esteem, life quality in adolescents with acne vulgaris.

    Science.gov (United States)

    Unal, Dilek; Emiroğlu, Nazan; Cengiz, Fatma Pelin

    2016-08-05

    Acne vulgaris is a visible skin disease commonly seen in adolescence. As it affects the appearance, it is likely to bring stress to the adolescent's life regarding sensitivity about their appearance. The aim of the study was to investigate the social anxiety level, acne-specific life quality, and self-esteem among adolescents with acne vulgaris. In addition, we evaluated the relationship between these parameters, clinical severity, and sociodemographic data. One hundred and two adolescents with acne vulgaris, aged 12-17 years without any psychiatric or medical comorbidity were recruited. The control group consisted of 83 adolescents in the same age range, who had neither psychiatric disease nor acne. Sociodemographic form (SDF), Capa Social Phobia Scale for Children and Adolescents (CSPSCA), and Rosenberg Self-esteem Scale (RSES) were applied to both groups. Additionally, the severity of acne was determined with Global Acne Grading System (GAGS), and life quality of the patients was evaluated with Acne Quality of Life Scale (AQOL). There was no significant difference in social anxiety levels and self-esteem between the study and control groups. Life quality impairment and high social anxiety levels, as well as low self-esteem, were found to be associated regardless of the clinical severity. Clinicians should be aware of the psychiatric comorbidities when treating adolescents with acne vulgaris. Especially, low self-esteem and life quality impairment should warn clinicians to predict high social anxiety levels in adolescent acne patients.

  1. Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Yoshinobu Eishi

    2013-01-01

    Full Text Available Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces pulmonary granulomas in mice sensitized with the protein and adjuvant, but only those with latent P. acnes infection in their lungs. Eradication of P. acnes by antibiotics prevents the development of granulomas in this experimental model. Although P. acnes is the most common commensal bacterium in the lungs and lymph nodes, P. acnes-specific antibody detected the bacterium within sarcoid granulomas of these organs. P. acnes can cause latent infection in the lung and lymph node and persist in a cell-wall-deficient form. The dormant form is activated endogenously under certain conditions and proliferates at the site of latent infection. In patients with P. acnes hypersensitivity, granulomatous inflammation is triggered by intracellular proliferation of the bacterium. Proliferating bacteria may escape granulomatous isolation, spreading to other organs. Latent P. acnes infection in systemic organs can be reactivated by another triggering event, leading to systemic sarcoidosis.

  2. QUALITY OF LIFE AMONG ADOLESCENTS WITH ACNE IN A TERTIARY REFERRAL CENTRE IN BANGALORE

    Directory of Open Access Journals (Sweden)

    Belliappa Pemmanda Raju

    2016-08-01

    Full Text Available BACKGROUND Acne is a common problem in adolescent children and has a considerable impact on their quality of life. AIMS The impact of acne on quality of life (QoL in Indian adolescent patients remains undocumented. The study was undertaken to detect the impact of acne vulgaris in adolescents on the QoL using 2 questionnaires: The Children’s Dermatology Life Quality Index (CDLQI and the Cardiff Acne Disability Index (CADI. MATERIALS AND METHODS This was a hospital-based, prospective, cross-sectional, pre-structured, questionnaire-based study done on 140 consenting individuals, who attended the Acne Clinic of our Dermatology Outpatient Department. Acne vulgaris was graded using simple grading system. QoL was measured using a combination of skin disease-specific (Children’s Dermatological Life Quality Index (CDLQI and acne-specific (Cardiff Acne Disability Index (CADI questionnaires. RESULTS The study population included 140 cases with a female to male ratio of 1.5:1. Comedones (123, 87.9% were the most common type of lesion. Grade I acne was the most common clinical type (76.4%. There was a statistically significant difference between acne severity and gender. The overall mean CDLQI score (7.21 of max. 30 and the overall mean CADI score (4.8 of max. 15 were low, indicating a mild impairment of QoL among adolescents. Statistically significant association was noted between CDLQI and CADI scores and grade of acne. There was no statistically significant association noted between CDLQI and CADI scores and gender. CONCLUSION Though acne had impact on patient’s QoL, it was less severe in our study. The CDLQI and CADI questionnaires represent simple and reliable instruments for the assessment of QoL among adolescents and should be incorporated when managing acne patients to provide better and appropriate care.

  3. Translation, cultural adaptation and validation for Brazilian Portuguese of the Cardiff Acne Disability Index instrument.

    Science.gov (United States)

    Grando, Luciana Rosa; Horn, Roberta; Cunha, Vivian Trein; Cestari, Tania Ferreira

    2016-04-01

    The Cardiff Acne Disability Index was originally developed in English for measuring quality of life of acne patients. Considering the psychosocial impact of this disease, it is important to have instruments culturally and linguistically validated for use in Brazilian adolescents. To translate the Cardiff Acne Disability Index into Brazilian Portuguese, culturally adapt it, and verify its reliability and validity in adolescent patients with acne. In the first step, the Cardiff Acne Disability Index was translated and validated linguistically to Brazilian Portuguese in accordance with international guidelines published. In the second step, the validation of the Cardiff Acne Disability Index into Brazilian Portuguese instrument was performed, when patients aged from 12 to 20 years with acne were selected. The participants were interviewed to collect demographic data, submitted to the classification of acne by the Global Acne Grading System and invited to respond the Cardiff Acne Disability Index into Brazilian Portuguese version and DLQI (>16 years) or CDLQI (≤16 years). The internal consistency of Cardiff Acne Disability Index into Brazilian Portuguese was assessed by Cronbach's alpha coefficient and concurrent validity was measured by the Spearman correlation coefficient and Student 's t-test for paired samples. The study included 100 adolescents. The Cardiff Acne Disability Index into Brazilian Portuguese version showed good reliability and internal consistency (Cronbach's alpha = 0.73). The concurrent validity of the scale was supported by a strong and significant correlation with CDLQI / DLQI instruments (rs=0.802;pPortuguese version is a reliable, valid and valuable tool to measure the impact of acne on quality of life in adolescent patients.

  4. Effects of bee venom against Propionibacterium acnes-induced inflammation in human keratinocytes and monocytes.

    Science.gov (United States)

    Kim, Jung-Yeon; Lee, Woo-Ram; Kim, Kyung-Hyun; An, Hyun-Jin; Chang, Young-Chae; Han, Sang-Mi; Park, Yoon-Yub; Pak, Sok Cheon; Park, Kwan-Kyu

    2015-06-01

    Propionibacterium acnes (P. acnes) cause inflammatory acne and play an important role in the pathogenesis of acne by inducing inflammatory mediators. P. acnes contributes to the inflammatory responses of acne by activating inflammatory cells, keratinocytes and sebocytes to secrete pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-8. Bee venom has traditionally been used in the treatment of certain immune-related diseases. However, there has not yet been a robust trial to prove the therapeutic effect of bee venom in skin inflammation. The aim of the present study was to investigate anti-inflammatory properties of bee venom in skin inflammation induced by P. acnes using keratinocytes (HaCaT) and monocytes (THP-1). P. acnes is known to stimulate the production of pro-inflammatory cytokines such as IL-1, IL-8, IL-12 and TNF-α. In the present study, the production of interferon-γ (IFN-γ), IL-1β, IL-8 and TNF-α was increased by P. acnes treatment in HaCaT and THP-1 cells. By contrast, bee venom effectively inhibited the secretion of IFN-γ, IL-1β, IL-8 and TNF-α. Furthermore, P. acnes treatment activated the expression of IL-8 and toll-like receptor 2 (TLR2) in HaCaT cells. However, bee venom inhibited the expression of IL-8 and TLR2 in heat-killed P. acnes. Based on these results, it is concluded that bee venom has an effective anti-inflammatory activity against P. acnes in HaCaT and THP-1 cells. Therefore, we suggest that bee venom is an alternative treatment to antibiotic therapy of acne.

  5. A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Yanhan Wang

    2016-11-01

    Full Text Available Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. epidermidis, a probiotic skin bacterium can exploit glycerol fermentation to produce short-chain fatty acids (SCFAs which have antimicrobial activities to suppress the growth of P. acnes. Unlike glycerol, sucrose is chosen here as a selective fermentation initiator (SFI that can specifically intensify the fermentation activity of S. epidermidis, but not P. acnes. A co-culture of P. acnes and fermenting S. epidermidis in the presence of sucrose significantly led to a reduction in the growth of P. acnes. The reduction was abolished when P. acnes was co-cultured with non-fermenting S. epidermidis. Results from nuclear magnetic resonance (NMR analysis revealed four SCFAs (acetic acid, butyric acid, lactic acid, and succinic acid were detectable in the media of S. epidermidis sucrose fermentation. To validate the interference of S. epidermidis sucrose fermentation with P. acnes, mouse ears were injected with both P. acnes and S. epidermidis plus sucrose or phosphate buffered saline (PBS. The level of macrophage-inflammatory protein-2 (MIP-2 and the number of P. acnes in ears injected with two bacteria plus sucrose were considerably lower than those in ears injected with two bacteria plus PBS. Our results demonstrate a precision microbiome approach by using sucrose as a SFI for S. epidermidis, holding future potential as a novel modality to equilibrate dysbiotic acne.

  6. Designing a fractal antenna of 2400 MHz

    International Nuclear Information System (INIS)

    Miranda Hamburger, Fabio

    2012-01-01

    The design of a fractal antenna with 2400 MHz of frequency has been studied. The fractal used is described by Waclaw Spierpi.ski. The initial figure, also known as seed, is divided using equilateral triangles with the aim of obtaining a perimeter similar to a meaningful portion of wave length. The use of λ to establish an ideal perimeter has reduced the radiation resistance. The adequate number of iterations needed to design the antenna is calculated based on λ. (author) [es

  7. Construction of the LITL cavity structure

    International Nuclear Information System (INIS)

    Itoh, S.; Masuda, S.; Ukai, Y.; Hirao, Y.

    1984-01-01

    This report presents briefly the mechanical consideration for the 100 MHz four-vane RFQ (radio frequency quadrupole accelerator) structure construction. At first, the theoretical vane shape required to obtain the RFQ electric field distribution was determined. A numerically controlled milling machine was employed for the precise machining of the complicated shape. The data sets for NC machining and for checking the size of three-dimensional coordinates were made up. A small vane model was machined by way of trial experiment to check the data to verify the circular interpolation programmed NC machining method, and to investigate cutter interference. The errors in the measurement in machining were less than +- 30 micrometer. The resonator tank is 56 cm in inner diameter and 138 cm in length, and is made of mild steel of 35 mm thickness. The inside wall was plated with copper thickly. Various conditions for the copper plating were investigated. Four vanes were assembled within the cavity of the RFQ. The vanes were built in the cavity tank with high dimensional accuracy. It was a matter of primary concern to design acceptable mechanical rf joints and select suitable rf contact elements for a high Q value of the RFQ resonator cavity. Finally, the Q value was measured, and was 10,600. The cavity was able to be evacuated to 10 -7 Torr. (Kato, T.)

  8. A prototype superconducting cavity for TRISTAN

    International Nuclear Information System (INIS)

    Furuya, T.; Hara, K.; Hosoyama, K.

    1987-01-01

    Following the feasibility study on the 3-cell superconducting cavity in the TRISTAN Accumulation Ring (TAR), a 5-cell 508 MHz Nb cavity was constructed and tested in the TAR. The cavity was equipped with a RF input coupler on a beam pipe, two HOM couplers on the other beam pipe and two additional HOM couplers on the equator of an end cell. The maximum accelerating field (Eaxx) was 4.5 MV/m with a Q value of about 1x10 9 at 4.2 deg K. The field was limited by the electron field emission and neither electron multipacting nor breakdown caused by couplers was observed. Damping of the HOM was sufficient and the input coupler was tested up to 82 KW in total reflection. A frequency tuning system consisted of two piezo electric and mechanical tuners. The piezo tuner was fast enough and the mechanical tuner covered wide range. In the beam test, the single bunch electron current of 29 mA was captured by the superconducting cavity alone and 13 mA was accelerated to 4.8 GeV. The maximum power transferred to the beam was 26 KW. The refrigeration system worked very stably

  9. Travelling Wave Structure of an SPS RF Cavity

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    The RF cavities for acceleration of particles in the SPS have a travelling-wave structure. They operate at a fixed frequency of 200 MHz (h = 4620). With a quality factor of Q = 100, the bandwidth covers the small frequency swing for the acceleration of protons from as low as 10 GeV to the top energy of 450 GeV. Later on, for the acceleration of ions, with a larger frequency swing, turn-to-turn phase jumps did the trick. Two cavities, each consisting of 5 tank sections, were installed in long straight section 3. Each cavity is driven by a power amplifier of 750 kW CW (1 MW pulsed). Another 2 cavities were added later on. See also 7411033 and 7802190.

  10. An RF cavity for barrier bucket experiment in the AGS

    Energy Technology Data Exchange (ETDEWEB)

    Fujieda, M.; Iwashita, Y. [Kyoto Univ. (Japan); Mori, Y. [and others

    1998-11-01

    A barrier bucket experiment in the AGS is planed in 1998. An accumulation of the beam, which intensity of 1.0 x 10{sup 14}ppp is, acceleration after the injection with a barrier bucket scheme and other RF gymnastics experiments will be studied. An isolated RF pulse of 40 kV per cavity is necessary for the experiment. The RF frequency is 2 MHz and the isolated pulse is generated at the repetition rate of the revolution frequency of 357 kHz. We have developed the barrier cavity for this experiment. The cavity is loaded with FINEMET core. It has low Q value but high shunt impedance. It makes the necessary power less than that of ferrite-loaded cavity for an isolated RF pulse. (author)

  11. High-Q perpendicular-biased ferrite-tuned cavity

    International Nuclear Information System (INIS)

    Carlini, R.D.; Thiessen, H.A.; Potter, J.M.

    1983-01-01

    Rapid-cycling proton synchrotrons, such as the proposed LAMPF II accelerator, require approximately 10 MV per turn rf with 17% tuning range near 50 MHz. The traditional approach to ferrite-tuned cavities uses a ferrite which is longitudinally biased (rf magnetic field parallel to bias field). This method leads to unacceptably high losses in the ferrite. At Los Alamos, we are developing a cavity with transverse bias (rf magnetic field perpendicular to the bias field) that makes use of the tensor permeability of the ferrite. Modest power tests of a small (10-cm-dia) quarter-wave singly re-entrant cavity tuned by nickel-zinc ferrites and aluminum-doped garnets indicate that the losses in the ferrite can be made negligible compared with the losses due to the surface resistivity of the copper cavity at power levels from 2 to 200 watts

  12. Progress on the Design of a Perpendicularly Biased 2nd Harmonic Cavity for the Fermilab Booster

    Energy Technology Data Exchange (ETDEWEB)

    Madrak, R. L. [Fermilab; Dey, J. E. [Fermilab; Duel, K. L. [Fermilab; Kuharik, J. C. [Fermilab; Pellico, W. A. [Fermilab; Reid, J. S. [Fermilab; Romanov, G. [Fermilab; Slabough, M. [Fermilab; Sun, D. [Fermilab; Tan, C. Y. [Fermilab; Terechkine, I. [Fermilab

    2016-10-01

    perpendicularly biased 2nd harmonic cavity is being designed and built for the Fermilab Booster. Its purpose is to flatten the bucket at injection and thus change the longitudinal beam distribution to decrease space charge effects. It can also help at extraction. The cavity frequency range is 76 – 106 MHz. The power amplifier will be built using the Y567B tetrode, which is also used for the fundamental mode cavities in the Fermilab Booster. We discuss recent progress on the cavity, the biasing solenoid design and plans for testing the tuner's garnet material

  13. Heat transfer enhancement using 2MHz ultrasound.

    Science.gov (United States)

    Bulliard-Sauret, Odin; Ferrouillat, Sebastien; Vignal, Laure; Memponteil, Alain; Gondrexon, Nicolas

    2017-11-01

    The present work focuses on possible heat transfer enhancement from a heating plate towards tap water in forced convection by means of 2MHz ultrasound. The thermal approach allows to observe the increase of local convective heat transfer coefficients in the presence of ultrasound and to deduce a correlation between ultrasound power and Nusselt number. Heat transfer coefficient under ultrasound remains constant while heat transfer coefficient under silent conditions increases with Reynolds number from 900 up to 5000. Therefore, heat transfer enhancement factor ranges from 25% up to 90% for the same energy conditions (supplied ultrasonic power=110W and supplied thermal power=450W). In the same time cavitational activity due to 2MHz ultrasound emission was characterized from mechanical and chemical viewpoints without significant results. At least, Particle Image Velocimetry (PIV) measurements have been performed in order to investigate hydrodynamic modifications due to the presence of 2MHz ultrasound. It was therefore possible to propose a better understanding of heat transfer enhancement mechanism with high frequency ultrasound. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Sensitive detection of individual neutral atoms in a strong coupling cavity QED system

    International Nuclear Information System (INIS)

    Zhang Pengfei; Zhang Yuchi; Li Gang; Du Jinjin; Zhang Yanfeng; Guo Yanqiang; Wang Junmin; Zhang Tiancai; Li Weidong

    2011-01-01

    We experimentally demonstrate real-time detection of individual cesium atoms by using a high-finesse optical micro-cavity in a strong coupling regime. A cloud of cesium atoms is trapped in a magneto-optical trap positioned at 5 mm above the micro-cavity center. The atoms fall down freely in gravitation after shutting off the magneto-optical trap and pass through the cavity. The cavity transmission is strongly affected by the atoms in the cavity, which enables the micro-cavity to sense the atoms individually. We detect the single atom transits either in the resonance or various detunings. The single atom vacuum-Rabi splitting is directly measured to be Ω = 2π × 23.9 MHz. The average duration of atom-cavity coupling of about 110 μs is obtained according to the probability distribution of the atom transits. (authors)

  15. The psychosocial impact of acne, vitiligo, and psoriasis: a review

    Directory of Open Access Journals (Sweden)

    Nguyen CM

    2016-10-01

    Full Text Available Catherine M Nguyen,1 Kourosh Beroukhim,2 Melissa J Danesh,3 Aline Babikian,4 John Koo,3 Argentina Leon3 1University of California, Irvine School of Medicine, Irvine, 2David Geffen School of Medicine at UCLA, Los Angeles, 3Department of Dermatology, University of California San Francisco School of Medicine, San Francisco, 4Touro University College of Osteopathic Medicine, Vallejo, CA, USA Introduction: Chronic skin conditions have been well reported to affect a patient's quality of life on multiple dimensions, including the psychosocial domain. Psychosocial is defined as the interrelation of social factors with an individual's thoughts and behavior. The assessment of the psychosocial impact of skin disease on a patient can help direct the dermatologists' treatment goals. To evaluate the psychosocial impact of skin disease, we conducted a review of the literature on three skin conditions with onsets at various stages of life: acne, vitiligo, and psoriasis. Methods: A PubMed search was conducted in March 2015 using the terms “psychosocial” AND “acne”, “psychosocial” AND “vitiligo”, and “psychosocial” AND “psoriasis”. The results were limited to articles published in English in the past 5 years studying patients of all ages. Results and their references were evaluated for relevance according to their discussion of psychosocial qualities in their patients and the validity of psychosocial assessments. The search for acne yielded 51 results, and eleven were found to be relevant; vitiligo yielded 30 results with ten found to be relevant; and psoriasis yielded 70 results with seven found to be relevant. Results: According to the articles evaluated, 19.2% of adolescent patients with acne were affected in their personal and social lives. Social phobia was present in 45% of patients with acne compared to 18% of control subjects. Race and sex played a role in self-consciousness and social perceptions of the disease. Vitiligo

  16. Inhibitory effects of Cheongsangbangpoong-tang on both inflammatory acne lesions and facial heat in patients with acne vulgaris: A randomized controlled trial protocol.

    Science.gov (United States)

    Kim, Kyuseok; Kim, Kwan-Il; Lee, Junhee

    2016-01-22

    Due to increasing interest from acne patients concerned about the side effects associated with conventional therapies, complementary and alternative medicine (CAM) has been suggested as a new therapeutic modality for acne vulgaris. Herbal medicine is one of these CAM treatments. Cheongsangbangpoong-tang (CBT) is a common herbal formula used in patients with acne vulgaris in the clinical practice of Korean Medicine (KM). However, despite the common use of CBT in clinical practice, the current level of evidence is insufficient to support an inhibitory effect of CBT on inflammatory acne lesions and facial heat. Therefore, this study was designed to assess the inhibitory effect of CBT on both inflammatory acne lesions and facial heat. A randomized, double-blind, parallel-group, and placebo-controlled trial will be conducted. Fifty-six participants with acne vulgaris will be randomized into one of two groups: the CBT or placebo groups. After randomization, participants will be prescribed either CBT or placebo three times a day at a dose of 5 g after meals for 8 weeks. The following outcome measurements will be used in the examination of subjects: the mean percentage change and the count change of the inflammatory and non-inflammatory acne lesions, the temperature of facial points on digital infrared thermal imaging (DITI), serum cortisol, serum dehydroepiandrosterone-sulfate (DHEA-S), visual analogue scale (VAS), investigator global assessment (IGA), and severity score on the Korean Acne Grading System (KAGS) from baseline to the end of the trial. This trial will provide evidence regarding the inhibitory effect of CBT on inflammatory acne lesions and facial heat. The findings of this trial may have important implications for the more widespread use of CBT for the treatment of acne vulgaris. The trial is registered with the Clinical Research Information Service (CRiS), Republic of Korea: KCT0001468 .

  17. Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients.

    Science.gov (United States)

    Jacyk, W K; Mpofu, P

    2001-10-01

    Acne vulgaris is a common dermatologic disease in African patients, as well as in Caucasians. Our report evaluates the safety and efficacy of adapalene gel 0.1% in African patients with acne vulgaris. We used a 12-week, 2-center, open-label, noncomparative study of adapalene gel 0.1% in 65 African patients with acne vulgaris to assess the drug's effect on hyperpigmented lesions in people with dark skin. The study demonstrated that the progressive and significant improvements in lesion counts and global acne grades produced by adapalene in African patients were paralleled by significant improvements in the degree of hyperpigmentation of acne lesions. During treatment with adapalene, less than 5% of patients reported moderate or severe skin irritation at any time during the study, and the incidence of skin oiliness decreased markedly. We conclude that adapalene gel 0.1% was well tolerated and highly effective in African patients with acne vulgaris and was found to reduce hyperpigmentation.

  18. The microsponge delivery system reduces facial oiliness and shine during acne therapy.

    Science.gov (United States)

    Kircik, Leon H

    2013-11-01

    Acne therapies that are able to show efficacious treatment of acne lesions as well as to address the issues of oiliness and shine control may be particularly appropriate for the treatment of patients with acne vulgaris that is accompanied by oily skin and facial shine. The microsphere delivery system (MDS), a novel delivery technology for topical therapy, can be customized to optimize product attributes, including oil absorption. Clinical trials have clearly established the efficacy and tolerability of such MDS formulations in the treatment of acne. In addition, studies have shown that the use of products formulated with an MDS provides a more significant reduction in facial shine than non-MDS acne therapy, as well as a reduction in facial sebum accumulation relative to control. Future clinical research should aim to further delineate the effect of individual topical acne treatment formulations on oiliness and shine.

  19. Psychological impact of isotretinoin treatment in patients with moderate and severe acne.

    Science.gov (United States)

    Simić, Dubravka; Situm, Mirna; Letica, Edita; Penavić, Jasna Zeljko; Zivković, Maja Vurnek; Tomić, Teo

    2009-12-01

    Acne patients are subject to different degree of psychosocial distress. The emotional impact of acne vulgaris due to disfigurement caused by the disease is undisputed. Most common reactions to the acne are depression and anxiety. The use of isotretinoin, one of the most effective options in acne treatment, increases depression symptoms. The aim of this study was to investigate the psychological status of the patients with moderate to severe acne and to compare patients treated with isotretinoin with patients treated with vitamin C. A total of 85 patients suffering from acne vulgaris were included in the study. The results of this study do not find a significant correlation between the use of isotretinoin and the psychological effects of the drug.

  20. The use of oral antibiotics in treating acne vulgaris: a new approach.

    Science.gov (United States)

    Farrah, Georgia; Tan, Ernest

    2016-09-01

    Although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. The anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. Common prescribing practices in Dermatology exert significant selection pressure on bacteria, contributing to the development of antibiotic resistance. Antibiotic use for acne not only promotes resistance in Propionibacterium acnes, but also affects other host bacteria with pathogenic potential. This review will summarize the commonly used treatments for acne vulgaris, and how they should be combined as rational treatment. The indications for using oral antibiotics in acne will be highlighted. Strategies described in the literature to conserve the utility of oral antibiotics will be summarized. These include limiting the duration of antibiotic therapy, concomitant use of a topical non-antibiotic agent, use of subantimicrobial dose doxycycline, and the introduction of topical dapsone. © 2016 Wiley Periodicals, Inc.

  1. 53 MHZ Feedforward beam loading compensation in the Fermilab main injector

    International Nuclear Information System (INIS)

    Joseph E Dey et al.

    2003-01-01

    53 MHz feedforward beam loading compensation is crucial to all operations of the Main Injector. Recently a system using a fundamental frequency down converter mixer, a digital bucket delay module and a fundamental frequency up converter mixer were used to produce a one-turn-delay feedforward signal. This signal was then combined with the low level RF signal to the cavities to cancel the transient beam induced voltage. During operation they have shown consistently over 20 dB reduction in side-band voltage around the fundamental frequency during Proton coalescing and over 14 dB in multi-batch antiproton coalescing

  2. MHz-level self-sustained pulsation in polymer microspheres on a chip

    Directory of Open Access Journals (Sweden)

    Zhou-Chen Luo

    2014-12-01

    Full Text Available We observe MHz-level periodic self-sustained pulsation (SSP in the transmission spectrum of a polydimethylsiloxane (PDMS spherical microcavity on a silicon chip, under a fixed-frequency continuous laser excitation. The SSP results from the strong competition between the thermo-optic and thermal expansion effects of PDMS within the cavity mode volume. The experimental results show good agreement with the theoretical prediction by considering the modification of the thermal expansion coefficient and the temperature distribution within the mode volume.

  3. RF Characterization of Niobium Films for Superconducting Cavities

    CERN Document Server

    Aull† , S; Doebert, S; Junginger, T; Ehiasarian, AP; Knobloch, J; Terenziani, G

    2013-01-01

    The surface resistance RS of superconductors shows a complex dependence on the external parameters such as temperature, frequency or radio-frequency (RF) field. The Quadrupole Resonator modes of 400, 800 and 1200 MHz allow measurements at actual operating frequencies of superconducting cavities. Niobium films on copper substrates have several advantages over bulk niobium cavities. HIPIMS (High-power impulse magnetron sputtering) is a promising technique to increase the quality and therefore the performance of niobium films. This contribution will introduce CERNs recently developed HIPIMS coating apparatus. Moreover, first results of niobium coated copper samples will be presented, revealing the dominant loss mechanisms.

  4. Computer-aided design of the RF-cavity for a high-power S-band klystron

    Science.gov (United States)

    Kant, D.; Bandyopadhyay, A. K.; Pal, D.; Meena, R.; Nangru, S. C.; Joshi, L. M.

    2012-08-01

    This article describes the computer-aided design of the RF-cavity for a S-band klystron operating at 2856 MHz. State-of-the-art electromagnetic simulation tools SUPERFISH, CST Microwave studio, HFSS and MAGIC have been used for cavity design. After finalising the geometrical details of the cavity through simulation, it has been fabricated and characterised through cold testing. Detailed results of the computer-aided simulation and cold measurements are presented in this article.

  5. Fast Ferroelectric L-Band Tuner for Superconducting Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Jay L. Hirshfield

    2011-03-01

    Analysis and modeling is presented for a fast microwave tuner to operate at 700 MHz which incorporates ferroelectric elements whose dielectric permittivity can be rapidly altered by application of an external voltage. This tuner could be used to correct unavoidable fluctuations in the resonant frequency of superconducting cavities in accelerator structures, thereby greatly reducing the RF power needed to drive the cavities. A planar test version of the tuner has been tested at low levels of RF power, but at 1300 MHz to minimize the physical size of the test structure. This test version comprises one-third of the final version. The tests show performance in good agreement with simulations, but with losses in the ferroelectric elements that are too large for practical use, and with issues in bonding of ferroelectric elements to the metal walls of the tuner structure.

  6. Fast Ferroelectric L-Band Tuner for Superconducting Cavities

    International Nuclear Information System (INIS)

    Hirshfield, Jay L.

    2011-01-01

    Analysis and modeling is presented for a fast microwave tuner to operate at 700 MHz which incorporates ferroelectric elements whose dielectric permittivity can be rapidly altered by application of an external voltage. This tuner could be used to correct unavoidable fluctuations in the resonant frequency of superconducting cavities in accelerator structures, thereby greatly reducing the RF power needed to drive the cavities. A planar test version of the tuner has been tested at low levels of RF power, but at 1300 MHz to minimize the physical size of the test structure. This test version comprises one-third of the final version. The tests show performance in good agreement with simulations, but with losses in the ferroelectric elements that are too large for practical use, and with issues in bonding of ferroelectric elements to the metal walls of the tuner structure.

  7. 47 CFR 90.355 - LMS operations below 512 MHz.

    Science.gov (United States)

    2010-10-01

    ... PRIVATE LAND MOBILE RADIO SERVICES Intelligent Transportation Systems Radio Service § 90.355 LMS... LMS station and the nearest co-channel base station of another licensee operating a voice system is 75... MHz, 150-170 MHz, and 450-512 MHz bands may use either base-mobile frequencies currently assigned the...

  8. Association between smoking habits and acne vulgaris. A case-control study

    Directory of Open Access Journals (Sweden)

    Alice Mannocci

    2012-09-01

    Full Text Available

    Background: acne vulgaris, is one of the most common skin disorder. Previous studies about the role of smoke in the pathogenesis of acne reported contradictory results. The aim of this study was to conduct a case-control study investigating the relationship between tobacco smoking and acne.

    Methods: a case-control study was performed during the period September 2009 - February 2010. A questionnaire was administrated to each participant, to assess the association acne - smoke. Cases were outpatients of the Dermatologic Ambulatory of the “Fiorini” Hospital, Sapienza University of Rome (Italy. Controls were age and gender-matched to the cases. The ratio cases-controls was 1:2. A univariate and a multiple logistic regression analysis were conducted; Odds Ratio (OR and the relative 95% confidence interval (95%CI were assessed. The statistical significance was set at p < 0.05.

    Results: crude OR for the association acne - smoke was 7.26 (IC=2.27-23.18; adjusted OR for sex and age was 5.47 (IC=1.67-17.97. Of 93 cases, 6 had a severe grade of acne (6.5%, 19 had an intermediate grade of acne (20.4%, and 68 had a mild grade of acne (73.1%. No one of the smokers had a severe grade of acne, one had an intermediate grade of acne and 11 had mild acne; these differences are not statistically significant.

    Conclusions: the association between acne and smoke shows an increased risk (OR=7.26 with a statistically significant CI. Moreover, people ≥ 18 years of age have twice the risk compared to persons < 18 years of age (OR=2.31.

  9. A Report of Two Cases of Solid Facial Edema in Acne

    OpenAIRE

    Kuhn-R?gnier, Sarah; Mangana, Joanna; Kerl, Katrin; Kamarachev, Jivko; French, Lars E.; Cozzio, Antonio; Navarini, Alexander A.

    2017-01-01

    Introduction Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. Methods We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. Results Both cases responded to oral isotretinoin, in one case combined with oral steroids. Our cases...

  10. Antimicrobial efficacy of granulysin-derived synthetic peptides in acne vulgaris.

    Science.gov (United States)

    Lim, Hee-Sun; Chun, Seung-Min; Soung, Min-Gyu; Kim, Jenny; Kim, Seong-Jin

    2015-07-01

    Antimicrobial peptides are considered as a potential alternative to antibiotic treatment in acne vulgaris because the development of a resistant strain of Propionibacterium acnes is problematic. Granulysin can be regarded as an ideal substance with which to treat acne because it has antimicrobial and anti-inflammatory effects. This study was performed to explore the effectiveness of granulysin-derived peptides (GDPs) in killing P. acnes in vitro under a standard microbiologic assay and to evaluate their potential use in a topical agent for the treatment of acne vulgaris. Twenty different peptides based on the known sequence of a GDP were synthesized and tested in vitro for antimicrobial activity. Thirty patients with facial acne vulgaris were instructed to apply a topical formulation containing synthetic GDP to acne lesions twice per day for 12 weeks. A newly synthesized peptide in which aspartic acid was substituted with arginine, and methionine was substituted with cysteine, showed the highest antimicrobial activity against P. acnes. Moreover, it was effective against both Gram-positive and Gram-negative bacteria in vitro. After treatment with the topical formulation containing 50 ppm of synthetic peptide for 12 weeks, a significant reduction in the number of pustules was observed, regardless of the increase in the number of comedones. In addition, a significant reduction in the clinical grade of acne based on the Korean Acne Grading System (KAGS) was evident. Synthesized GDP shows strong antimicrobial activity against P. acnes in vitro. The clinical improvement observed suggests a topical formulation containing the GDP has therapeutic potential for the improvement of inflammatory-type acne vulgaris by its antimicrobial activity. © 2015 The International Society of Dermatology.

  11. Depressive symptoms, suicidal ideation and acne: a study of male Finnish conscripts.

    Science.gov (United States)

    Rehn, L M H; Meririnne, E; Höök-Nikanne, J; Isometsä, E; Henriksson, M

    2008-05-01

    To investigate the association among acne, depressive symptoms and suicidal ideation in Finnish male military conscripts. Consecutive 165 acne patients and 150 patients with mild knee symptoms for comparison were enrolled in the study conducted in the Central Military Hospital, Helsinki, Finland. They filled out the following questionnaires: General Health Questionnaire (GHQ-12), Beck Depression Inventory (BDI), Alcohol Use Disorders Identification Test and Rosenberg Self-Esteem Scale. The Leeds acne grading scale was used to estimate the severity of acne. Sixteen (9.7%) acne patients and 20 (13.3%) comparison patients had at least moderate level of depressive symptoms (BDI score 10; P > 0.05, between groups). Suicidal ideation (BDI suicidal item score 1) was reported by 24 (14.5%) acne patients and 16 (10.7%) comparison patients (P > 0.05, between groups). When comparing the mild facial acne patients (Leeds score 0-3) with those with moderate-severe facial acne (Leeds score 4), there were no statistical differences in depressive symptoms (9.5% vs. 10.0%) or suicidal ideation (13.7% vs. 15.7%). No linear relationship was observed between the BDI and facial Leeds scores (P > 0.05). Risk factors for suicidal ideation among the acne patients were depression and alcohol risk use. Young male patients with acne do not suffer more depressive symptoms or suicidal ideation than patients with mild knee symptoms, and the severity of acne is not associated with the presence of depressive symptoms. The risk factors for suicidal ideation among acne patients seem to be similar to those found in the general population.

  12. Perbedaan Self-Image Remaja Laki-Laki dan Perempuan Penderita Acne Vulgaris

    OpenAIRE

    Nasution, Fauziah Nami

    2016-01-01

    The research aims to find out the differences self-images on adolescent boy’s Acne Vulgaris patient and on adolescent girl’s. Self-image is the mental picture of an individual about his physical appearance Jersild (1963). Acne vulgaris is a chronic inflammation of the follicle polisebasea characterized by comedones, papules, pustules, and cysts in predilection areas, such as the face, shoulders, chest, and back. The population of the research is senior students in Medan who have Acne Vulgaris...

  13. Cryogenic tunable microwave cavity at 13GHz for hyperfine spectroscopy of antiprotonic helium

    International Nuclear Information System (INIS)

    Sakaguchi, J.; Gilg, H.; Hayano, R.S.; Ishikawa, T.; Suzuki, K.; Widmann, E.; Yamaguchi, H.; Caspers, F.; Eades, J.; Hori, M.; Barna, D.; Horvath, D.; Juhasz, B.; Torii, H.A.; Yamazaki, T.

    2004-01-01

    For the precise measurement of the hyperfine structure of antiprotonic helium, microwave radiation of 12.9GHz frequency is needed, tunable over +/-100MHz. A cylindrical microwave cavity is used whose front and rear faces are meshed to allow the antiprotons and laser beams to enter. The cavity is embedded in a cryogenic helium gas target. Frequency tuning of ∼300MHz with Q values of 2700-3000 was achieved using over-coupling and an external triple stub tuner. We also present Monte-Carlo simulations of the stopping distribution of antiprotons in the low-density helium gas using the GEANT4 package with modified energy loss routines

  14. Thyroid neoplasms after radiation therapy for adolescent acne vulgaris

    International Nuclear Information System (INIS)

    Paloyan, E.; Lawrence, A.M.

    1978-01-01

    There is a potential hazard of thyroid cancer after exposure to external irradiation for the treatment of adolescent acne vulgaris. We noted a 60% incidence of thyroid carcinoma among 20 patients with such a history, who were operated on for thyroid nodules during a five-year period. Eighty-three percent of the patients with carcinoma had either a follicular or a mixed papillary-follicular carcinoma; 17% had a papillary carcinoma; 33% had regional node metastases; none had evidence of distant metastases. The interval between radiation exposure and thyroidectomy ranged from nine to 41 years. This association of thyroid neoplasms and a prior history of radiation for acne vulgaris may be coincidental and therefore remains to be proved by retrospective surveys of large numbers of treated patients with appropriate controls

  15. Acute post-traumatic endophthalmitis secondary to Propionibacterium acnes

    Science.gov (United States)

    Shailaja, S; Kamath, Yogish; Hazarika, Manali; Vishwanath, Shashidhar

    2013-01-01

    Propionibacterium acnes has rarely been reported as the causative organism in acute endophthalmitis following penetrating ocular trauma. We report a 53-year-old man, who presented with best corrected vision of counting fingers at 2 m, acnes. At the fifth month follow-up, the best corrected vision had improved to 20/20, N6. Thus, a good visual outcome was achieved, following appropriate treatment of a rather unusual causative organism. PMID:24096075

  16. An infrared free electron laser system for the proposed Chemical Dynamics Research Laboratory at LBL based on a 500 MHz superconducting linac

    International Nuclear Information System (INIS)

    Kim, K.J.; Byrns, R.; Chattopadhyay, S.; Donahue, R.; Edighoffer, J.; Gough, R.; Hoyer, E.; Leemans, W.; Staples, J.; Taylor, B.; Xie, M.

    1992-09-01

    We describe a new design of the Infrared Free Electron Laser (IRFEL) for the proposed Chemical Dynamics Research Laboratory (CDRL) at LBL. The design and choice of parameters are dictated by the unique requirements of the CDRL scientific program. The accelerator system is based on the 500 MHz superconducting cavity technology to achieve a wavelength stability of 10 -4

  17. Light/laser therapy in the treatment of acne vulgaris.

    Science.gov (United States)

    Nouri, Keyvan; Villafradez-Diaz, L Magaly

    2005-12-01

    Acne vulgaris is one of the most prevalent skin diseases known. As common as this condition is, the social and psychological consequences are limitless. Although current treatments are available and include topical or oral antibiotics, it is crucial to develop a less risky and more effective therapy such as light/laser therapy. This article focuses specifically on the benefits of the light/laser treatment on acne vulgaris. Porphyrins accumulated in the bacteria, Propionibacterium acnes, one of the etiologic factors involved in the pathogenesis, allows phototherapy to be a successful modality. They have specific absorption peaks at which lasers have optimal effects. The longer the wavelength of the light is, the deeper its penetration and thus the greater its damage to the sebaceous glands. Although blue light is best for the activation of porphyrins, red light is best for deeper penetration and an anti-inflammatory effect. Ultraviolet (UV) light, although it may have initial an anti-inflammatory effects, has been proven to be potentially carcinogenic and have adverse effects such as aging (by UV-A) and burning (by UV-B). Previous studies indicate successful long-term intervention and selective damage of the sebaceous glands by using a diode laser with indocyanine green (ICG) dye. Mid-infrared lasers have been found to decrease lesion counts while also reducing the oiliness of skin and the scarring process. Nonablative laser treatment of acne scars using the Er:YAG laser with a short-pulsed mode has been successful in reducing the appearance of scars by stimulating neocollagenesis. The light/laser therapy has started to be explored with promising results in highly selected patients that require further investigation in greater populations and well-designed protocols.

  18. 367 cases of CO2 laser therapy on facial acne

    Science.gov (United States)

    Gao, Yunqing; Liu, Songhao; Zhang, You; Liu, T. C.

    1996-09-01

    Since 1989, we have cured 367 persons of facial acne of different course by using direct irradiation of high-power CO2 laser combing with operative therapy of low-power CO2 laser. The cure rate is 100 percent. In this paper, we stated the therapeutic approach. It was shown that this therapeutic approach is simple and effective, and its recurrence rate is zero. There are no cicatrices after healing. It is easy to accept it, and is worthy of extension.

  19. Use of oral contraceptives in the management of acne

    OpenAIRE

    Melis, Gian; Paoletti,Anna Maria; ORRU' ,; MAROTTO ,; PILLONI,; PERSEU,; Lello,Stefano

    2011-01-01

    Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland) originates from increased sebum production by the sebaceous gland followed by colonization o...

  20. Cutibacterium acnes molecular typing: time to standardize the method.

    Science.gov (United States)

    Dagnelie, M-A; Khammari, A; Dréno, B; Corvec, S

    2018-03-12

    The Gram-positive, anaerobic/aerotolerant bacterium Cutibacterium acnes is a commensal of healthy human skin; it is subdivided into six main phylogenetic groups or phylotypes: IA1, IA2, IB, IC, II and III. To decipher how far specific subgroups of C. acnes are involved in disease physiopathology, different molecular typing methods have been developed to identify these subgroups: i.e. phylotypes, clonal complexes, and types defined by single-locus sequence typing (SLST). However, as several molecular typing methods have been developed over the last decade, it has become a difficult task to compare the results from one article to another. Based on the scientific literature, the aim of this narrative review is to propose a standardized method to perform molecular typing of C. acnes, according to the degree of resolution needed (phylotypes, clonal complexes, or SLST types). We discuss the existing different typing methods from a critical point of view, emphasizing their advantages and drawbacks, and we identify the most frequently used methods. We propose a consensus algorithm according to the needed phylogeny resolution level. We first propose to use multiplex PCR for phylotype identification, MLST9 for clonal complex determination, and SLST for phylogeny investigation including numerous isolates. There is an obvious need to create a consensus about molecular typing methods for C. acnes. This standardization will facilitate the comparison of results between one article and another, and also the interpretation of clinical data. Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  1. Efficacy and Safety of Topical Niacinamide for Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Zeynep Nurhan Saraçoğlu

    2011-06-01

    Full Text Available Background and Design: To investigate the efficacy and safety of topical 4% naicinamide gel cream in the treatment of mild to moderate acne vulgaris and to assess the quality of life of acne patients.Material and Method: Twenty-nine female patients aged 16-38 (mean: 23.57±5.42 years with mild to moderate acne vulgaris who presented in dermatology outpatient clinic were enrolled in the study. All patients applied 4% niacinamide gel cream (Vivatinell-acnecinamide gel cream® on their faces twice daily for eight weeks. The number of lesions (inflammatory and non-inflammatory was counted at 0, 2, 4 and 8 weeks. The side effects (erythema, desquamation, burning and dryness were recorded. The Skindex-29, a quality-of-life measure for patients with skin disease, was administered to the subjects at the beginning and the end of treatment.Results: The decrease in the mean number of inflammatory lesions was statistically significant at the end of the treatment (pre-treatment vs. post-treatment: 12.24 vs. 6.14; p =0.000. However, there was no statistically significant decrease in the number of non-inflammatory lesions at the end of the eight weeks. The niacinamide gel cream was generally well tolerated. There was statistically significant improvement in the Skindex-29 scale scores (p =0.000 at the end of the treatment.Conclusion: Topical 4% niacinamide gel cream may be an alternative treatment for inflammatory lesions of mild to moderate acne vulgaris.

  2. The effect of probiotics on immune regulation, acne, and photoaging

    Directory of Open Access Journals (Sweden)

    Mary-Margaret Kober

    2015-06-01

    Full Text Available Probiotics are live micro-organisms that provide a health benefit to the host. The role of probiotics in the management of disease, as well as immune modification, has recently experienced a renewed interest in society, as probiotics can be found in products ranging from yogurt to facial creams. In this article, we discuss the role of probiotics in the development of the immune system, the treatment of acne and rosacea, and protection against aging and photodamage.

  3. Measurement of Nitrogen Hyperfine Structure on the 53 CM (562 MHz) Butyronitrile Line

    Science.gov (United States)

    Dewberry, Christopher T.; Grubbs, Garry S. Grubbs, II; Raphelt, Andrew; Cooke, Stephen A.

    2009-06-01

    Recent improvements to our cavity-based Fourier transform radiofrequency spectrometer will be presented. Amongst other improvements use of Miteq amp, model AMF-6F-00100400-10-10P (0.1 GHz to 4 GHz, 65 dB gain minimum, 1 dB noise figure maximum) together with shielding from an improved Faraday cage have significantly helped us in this regard. Electromagnetic fields within our near-spherical cavity have been modeled and results will be presented. We have been able to easily resolve the nitrogen hyperfine structure on the ^aQ_{0,-1} transition 1_{1,0} ← 1_{1,1} located at 562 MHz. This result will be discussed.

  4. Computer simulation and cold model testing of CCL cavities

    International Nuclear Information System (INIS)

    Chang, C.R.; Yao, C.G.; Swenson, D.A.; Funk, L.W.

    1993-01-01

    The SSC coupled-cavity-linac (CCL) consists of nine modules with eight tanks in each module. Multicavity magnetically coupled bridge couplers are used to couple the eight tanks within a module into one RF resonant chain. The operating frequency is 1282.851 MHz. In this paper the authors discuss both computer calculations and cold model measurements to determine the geometry dimension of the RF structure

  5. Observational study of Arctium lappa in the treatment of acne vulgaris.

    Science.gov (United States)

    Miglani, Anjali; Manchanda, Raj K

    2014-07-01

    Arctium lappa (Lappa) is used in traditional Western and Chinese medicine for acne. It is mentioned in homeopathic literature for acne, but its effect has not previously been evaluated. To determine the effectiveness of homeopathic medicine Lappa in treatment of acne vulgaris. An uncontrolled observational interventional study was conducted on human subjects who fulfilled the inclusion criteria and gave written informed consent. Lappa was prescribed in potencies starting from 6c rising to 1M as required, over a period of 6 months. Objective assessment was change in acne lesion counts supplemented with Global Acne Grading System (GAGS) and subjective assessment by using Acne-Specific Quality of Life questionnaire (Acne-QoL). Out of 34 human subjects, 32 completed the follow-up. Statistical significant results were seen in lesion counts, GAGS and Acne-QoL score (p value Lappa has shown positive effects in the treatment of acne especially of inflammatory type. Further controlled, randomized studies with larger sample size are desirable. Trial is registered at ClinicalTrials.gov Identifier: NCT01040390. Copyright © 2013 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

  6. A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

    Directory of Open Access Journals (Sweden)

    Laila Shirbeigi

    2016-02-01

    Full Text Available Context Iranian traditional medicine (ITM is based on humoral theory. Temperament or Mizaj is the result of a combination of four cardinal humors. They are blood, phlegm, yellow bile (Safra and black bile (melancholy. Like any other disease, acne is the result of humoral imbalance. Acne is a highly prevalent dermatologic problem, which has both physical and psychological effects. The aim of this study was to introduce the etiology of acne and its remedies from the perspective of ITM. Evidence Acquisition Etiology and treatment of acne were studied and analyzed from selected medical textbooks of ITM. Some of the effective plants in these books were assessed in a table, and their anti-acne activities were compared with conventional medicine’s database. Results From the perspective of ITM, considering six essential schemes for health, diet and herbal remedies as well as manipulation are recommended for acne treatment. Although the introduced plants have antibacterial, anti-inflammatory and antioxidant effects but some of them have special proven effects on acne formation process. There is also a strong relationship between digestive system and skin. Conclusions This paper was rendered to show ancient Persian scholar’s point of view about acne and its treatment, and it was shown that Iranian traditional medicine has practical recommendations for acne treatment.

  7. Use of Oral Contraceptives for Management of Acne Vulgaris: Practical Considerations in Real World Practice.

    Science.gov (United States)

    Harper, Julie C

    2016-04-01

    Acne vulgaris may be effectively treated with combination oral contraceptive pills (COCs) in women. COCs may be useful in any woman with acne in the absence of known contraindications. When prescribing a COC to a woman who also desires contraception, the risks of the COC are compared with the risks associated with pregnancy. When prescribing a COC to a woman who does not desire contraception, the risks of the COC must be weighed against the risks associated with acne. COCs may take 3 cycles of use to show an effect in acne lesion count reductions. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin

    Science.gov (United States)

    Bek-Thomsen, Malene; Lomholt, Hans B.; Scavenius, Carsten; Enghild, Jan J.; Brüggemann, Holger

    2014-01-01

    Acne vulgaris is a very common disease of the pilosebaceous unit of the human skin. The pathological processes of acne are not fully understood. To gain further insight sebaceous follicular casts were extracted from 18 healthy and 20 acne-affected individuals by cyanoacrylate-gel biopsies and further processed for mass spectrometry analysis, aiming at a proteomic analysis of the sebaceous follicular casts. Human as well as bacterial proteins were identified. Human proteins enriched in acne and normal samples were detected, respectively. Normal follicular casts are enriched in proteins such as prohibitins and peroxiredoxins which are involved in the protection from various stresses, including reactive oxygen species. By contrast, follicular casts extracted from acne-affected skin contained proteins involved in inflammation, wound healing and tissue remodeling. Among the most distinguishing proteins were myeloperoxidase, lactotransferrin, neutrophil elastase inhibitor and surprisingly, vimentin. The most significant biological process among all acne-enriched proteins was ‘response to a bacterium’. Identified bacterial proteins were exclusively from Propionibacterium acnes. The most abundant P. acnes proteins were surface-exposed dermatan sulphate adhesins, CAMP factors, and a so far uncharacterized lipase in follicular casts extracted from normal as well as acne-affected skin. This is a first proteomic study that identified human proteins together with proteins of the skin microbiota in sebaceous follicular casts. PMID:25238151

  9. THE ROLE OF INFLAMMATORY CYTOKINES IN THE INITIATION AND COURSE OF ACNE: A MODERN VIEW

    Directory of Open Access Journals (Sweden)

    A. V. Kormilitcyna

    2017-01-01

    Full Text Available The publication provides an overview of current scientific and medical literature devoted to the study of mechanisms of immunopathogenesis of acne. The concept of the pathophysiology and immunopathogenesis of acne expanded significantly in recent years, many scientists have pointed out the link between the presence of acne and disorders of the endocrine, nervous, digestive and immune systems. Despite the fact that the individual links in the pathogenesis of acne are well studied, there are still questions about the role of commensal Propionibacterium acnes in the initiation and development of acne. So far there is no information on the number of P. acnes in healthy and diseased skin, the relationship between the numder of P. acnes and severity of the disease, also an important question remains unanswered — why do P. acnes cause inflammation for some people, while it don`t for the others? Despite the presence of bacterial factor in the pathogenesis of acne, there are a large number of studies showing that the nature of the patient’s immune response to P. acnes is more important than the infectious agent. For quite a long time data was received that proinflammatory cytokines play an important role in the initiation of acne. Interleukins IL-6 and IL-8 are involved in the stimulation of sebum hypersecretion, and subpopulation Th1 derived from a patient with acne, recognize P. acnes antigens. A number of recently obtained results suggest that P. acnes is a potent inducer of Th17 and Th1, and the study of the role of proinflammatory cytokines in the development of acne suggests new possibilities of acne therapy. Presented in this article is a clinical case clearly illustrates the part of the immune inflammation in acne. Prospective areas of research on the role of signaling molecules in the pathogenesis of acne are covered: such as the mechanism of action of nitric oxide on the secretion of interleukin IL-1 beta, which was shown as

  10. LEP copper accelerating cavities

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    These copper cavities were used to generate the radio frequency electric field that was used to accelerate electrons and positrons around the 27-km Large Electron-Positron (LEP) collider at CERN, which ran from 1989 to 2000. The copper cavities were gradually replaced from 1996 with new superconducting cavities allowing the collision energy to rise from 90 GeV to 200 GeV by mid-1999.

  11. High-flux cold rubidium atomic beam for strongly-coupled cavity QED

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Basudev [Indian Institute of Science Education and Research, Kolkata (India); University of Maryland, MD (United States); Scholten, Michael [University of Maryland, MD (United States)

    2012-08-15

    This paper presents a setup capable of producing a high-flux continuous beam of cold rubidium atoms for cavity quantum electrodynamics experiments in the region of strong coupling. A 2D{sup +} magneto-optical trap (MOT), loaded with rubidium getters in a dry-film-coated vapor cell, fed a secondary moving-molasses MOT (MM-MOT) at a rate greater than 2 x 10{sup 10} atoms/s. The MM-MOT provided a continuous beam with a tunable velocity. This beam was then directed through the waist of a cavity with a length of 280 μm, resulting in a vacuum Rabi splitting of more than ±10 MHz. The presence of a sufficient number of atoms in the cavity mode also enabled splitting in the polarization perpendicular to the input. The cavity was in the strong coupling region, with an atom-photon dipole coupling coefficient g of 7 MHz, a cavity mode decay rate κ of 3 MHz, and a spontaneous emission decay rate γ of 6 MHz.

  12. Combination therapy in the management of atrophic acne scars

    Directory of Open Access Journals (Sweden)

    Shilpa Garg

    2014-01-01

    Full Text Available Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively at 2-weeks interval for a total of 6 sessions of each. Grading of acne scar photographs was done pretreatment and 1 month after last procedure. Patients own evaluation of improvement was assessed. Results: Out of 16 patients with Grade 4 scars, 10 (62.5% patients improved to Grade 2 and 6 (37.5% patients improved to Grade 3 scars. Out of 22 patients with Grade 3 scars, 5 (22.7% patients were left with no scars, 2 (9.1% patients improved to Grade 1and 15 (68.2% patients improved to Grade 2. All 11 (100% patients with Grade 2 scars were left with no scars. There was high level of patient satisfaction. Conclusion: This combination has shown good results in treating not only Grade 2 but also severe Grade 4 and 3 scars.

  13. Hepatitis B, interferon, and acne fulminans in a young girl

    Directory of Open Access Journals (Sweden)

    Sandeep Arora

    2016-01-01

    Full Text Available Acne fulminans (AF is a very rare severe form of acne seen in young males, characterized by a sudden and explosive onset of hemorrhagic pustules and ulceration on the trunk, systemic features in the form of fever, polyarthropathy, malaise, erythema nodosum and painful osteolytic bone involvement with leukocytosis, and an elevated erythrocyte sedimentation rate. Conventional treatment of AF includes corticosteroids or immunosuppressive agents for the initial phase followed by isotretinoin. Active hepatitis B infection with a high viral load precludes the administration of any immunosuppressive drugs. We present the case of an 18-year-old girl with a history of occasional acne who presented with AF of sudden onset following administration of interferon-alpha-2a for her recently detected hepatitis B infection. Management of hepatitis B was withheld in view of her general condition. The patient was managed with low dose isotretinoin with subsidence of lesions. AF in a young female precipitated by interferon and its management with isotretinoin in the presence of active hepatitis B infection make the case unique.

  14. Could adult female acne be associated with modern life?

    Science.gov (United States)

    Albuquerque, R G R; Rocha, M A D; Bagatin, E; Tufik, S; Andersen, M L

    2014-10-01

    In recent years, the prevalence of adult female acne has increased, but the reason for this increase remains unclear. Acne is one of the most common skin disorders. It can be triggered or worsened by endogenous and exogenous factors, including genetic predisposition, hormone concentrations, diet, smoke and stress; although the interaction with this last factor is not well understood. Modern life presents many stresses including urban noises, socioeconomic pressures and light stimuli. Women are especially affected by stress during daily routine. The recent insertion in the labor market is added to the duties of the mother and wife. Women also have a higher risk of developing psychiatric disorders such as depression and anxiety. Sleep restriction is added to these factors, with several negative consequences on health, including on hormonal secretion and the immune system. This is further complicated by the natural variation in sleep architecture across the menstrual cycle. Recent studies have brought new data about the mechanisms and possible factors involved. This review aims to establish a connection between stress, sleep deprivation and adult female acne.

  15. 47 CFR 15.242 - Operation in the bands 174-216 MHz and 470-668 MHz.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the bands 174-216 MHz and 470-668... bands 174-216 MHz and 470-668 MHz. (a) The marketing and operation of intentional radiators under the... services, facilities, and beds for use beyond 24 hours in rendering medical treatment and institutions and...

  16. Use of oral contraceptives in the management of acne

    Directory of Open Access Journals (Sweden)

    Melis GB

    2011-11-01

    Full Text Available Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland originates from increased sebum production by the sebaceous gland followed by colonization of the hair follicle with Propionibacterium acnes, hyperkeratinization of the upper follicle, and release of inflammatory mediators into the skin. Androgens are the main stimulators of sebum production. Androgens originate from the gonads and adrenal glands, but can also be locally produced within the sebaceous gland from dehydroepiandrosterone sulfate. In the presence of high androgen levels, which can be either a normal pattern of adolescence or a consequence of gonadal or adrenal disease, overproduction of sebum triggers the pathogenesis of acne which, mainly in adolescent women, has deleterious psychological consequences. Estrogens exert the opposite action on sebum production, probably due to the reduction of androgen availability, a direct consequence of estrogen-related increased production of hepatic sex hormone-binding globulin (SHBG. The inhibition of the hypothalamus-pituitary axis induced by oral contraceptives is followed by reduced androgen production. Oral contraceptives containing ethinyl estradiol, which has strong estrogenic activity, amplify the hypoandrogenic effect via estrogen-related stimulation of SHBG. The hypoandrogenic effect of oral contraceptives is modulated by the progestin compound. Progestins derived from 19-nortestosterone bind androgenic receptors, whereas others exert antiandrogenic properties by antagonizing the binding of androgens to their receptors, reduce 5α-reductase, and do not bind SHBG. Through this last effect, SHBG is freely

  17. HOM Consideration of 704 MHz and 2.1 GHz Cavities for LEReC Linac

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Binping [RIKEN BNL; Belomestnykh, Sergey [SUNY, Stony Brook; Ben-Zvi, Ilan [RIKEN BNL; Blaskiewicz, Michael [RIKEN BNL; Brennan, Joseph [RIKEN BNL; Brutus, Jean Clifford [RIKEN BNL; Fedotov, Alexei [RIKEN BNL; Hahn, Harald [RIKEN BNL; McIntyre, Gary [RIKEN BNL; Pai, Chien [RIKEN BNL; Smith, Kevin [RIKEN BNL; Tuozzolo, Joseph [RIKEN BNL; Veshcherevich, Vadim [Cornell U., CLASSE; Wu, Qiong [RIKEN BNL; Xin, Tianmu [RIKEN BNL; Xu, Wencan [RIKEN BNL; Zaltsman, Alex [RIKEN BNL

    2016-06-01

    To improve RHIC luminosity for heavy ion beam energies below 10 GeV/nucleon, the Low Energy RHIC electron Cooler (LEReC) is currently under development at BNL. The Linac of LEReC is designed to deliver 2 MV to 5 MV electron beam, with rms dp/p less than 5·10⁻⁴. The HOM in this Linac is carefully studied to ensure this specification.

  18. Phase loop bandwidth measurements on the advanced photon source 352 MHz rf systems

    International Nuclear Information System (INIS)

    Horan, D.; Nassiri, A.; Schwartz, C.

    1997-01-01

    Phase loop bandwidth tests were performed on the Advanced Photon Source storage ring 352-MHz rf systems. These measurements were made using the HP3563A Control Systems Analyzer, with the rf systems running at 30 kilowatts into each of the storage ring cavities, without stored beam. An electronic phase shifter was used to inject approximately 14 degrees of stimulated phase shift into the low-level rf system, which produced measureable response voltage in the feedback loops without upsetting normal rf system operation. With the PID (proportional-integral-differential) amplifier settings at the values used during accelerator operation, the measurement data revealed that the 3-dB response for the cavity sum and klystron power-phase loops is approximately 7 kHz and 45 kHz, respectively, with the cavities the primary bandwidth-limiting factor in the cavity-sum loop. Data were taken at various PID settings until the loops became unstable. Crosstalk between the two phase loops was measured

  19. International inter-rater agreement in scoring acne severity utilizing cloud-based image sharing of mobile phone photographs.

    Science.gov (United States)

    Foolad, Negar; Ornelas, Jennifer N; Clark, Ashley K; Ali, Ifrah; Sharon, Victoria R; Al Mubarak, Luluah; Lopez, Andrés; Alikhan, Ali; Al Dabagh, Bishr; Firooz, Alireza; Awasthi, Smita; Liu, Yu; Li, Chin-Shang; Sivamani, Raja K

    2017-09-01

    Cloud-based image sharing technology allows facilitated sharing of images. Cloud-based image sharing technology has not been well-studied for acne assessments or treatment preferences, among international evaluators. We evaluated inter-rater variability of acne grading and treatment recommendations among an international group of dermatologists that assessed photographs. This is a prospective, single visit photographic study to assess inter-rater agreement of acne photographs shared through an integrated mobile device, cloud-based, and HIPAA-compliant platform. Inter-rater agreements for global acne assessment and acne lesion counts were evaluated by the Kendall's coefficient of concordance while correlations between treatment recommendations and acne severity were calculated by Spearman's rank correlation coefficient. There was good agreement for the evaluation of inflammatory lesions (KCC = 0.62, P cloud-based image sharing for acne assessment. Cloud-based sharing may facilitate acne care and research among international collaborators. © 2017 The International Society of Dermatology.

  20. The relationship between self-concept, self-esteem and perfectionism with the severity of acne in adolescents

    Directory of Open Access Journals (Sweden)

    Ali Afshari

    2017-10-01

     Conclusion: According to the findings of the study, adolescents are vulnerable to the psychosocial effects of acne. On this basis, considering mental health care along with medical treatment is necessary in acne treatment.

  1. Activity of capryloyl collagenic acid against bacteria involved in acne.

    Science.gov (United States)

    Fourniat, J; Bourlioux, P

    1989-12-01

    Synopsis Capryloyl collagenic acid (Lipacide C8Co) has similar bacteriostatic activity in vitro to that of benzoyl peroxide towards the bacteria found in acne lesions (Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes) (MIC between 1 and 4 mg ml(-1) for C8Co, and between 0.5 and 5 mg ml(-1) for benzoyl peroxide). The presence of Emulgine M8 did not affect the bacteriostatic activity of C8Co. A 4% w/v solution of C8Co (incorporating Emulgine M8) fulfilled the criteria for an antiseptic preparation as laid down by the French Pharmacopoeia (10th Edition), and had a spectrum 5 bactericidal activity according to the French Standard AFNOR NF T 72-151. The excellent cutaneous tolerance of capryloyl collagenic acid would indicate that an aqueous solution might be of value for topical treatment of the bacterial component of acne. Résumé Activité antibactérienne de l'acide capryloyl-collagénique vis à vis des bactéries impliquées dans l'etiologie de l'acné L'acide capryloyl-collagénique (Lipacide C8Co) et le peroxyde de benzoyle présentent une activité bactériostatique in-vitroéquivalente vis à vis des espèces bactériennes retrouvées au niveau des lésions acnéiques (Staphylococcus aureus, S. epidermidis et Propionibacterium acnes) (CMI comprise entre 1 et 4 mg ml(-1) pour le lipoaminoacide, et 0,5 et 5 mg ml(-1) pour le peroxyde de benzoyle). La mise en solution aqueuse de l'acide capryloyl-collagénique en présence d'Emulgine M8 ne modifie pas son activité bactériostatique. Une telle solution, à 4% m/V d'acide capryloyl-collagénique et 5% m/V d'Emulgine M8, satisfait à l'essai d'activité des préparations antiseptiques décrit à la Pharmacopée Française (Xème Ed.) (concentration minimale antiseptique: 10% v/V, pour un temps de contact de 5 min à 32 degrees C entre les germes tests et la solution diluée en eau distillée), et posséde une activité bactéricide antiseptique spectre 5 conforme à la norme AFNOR NF T

  2. Niobium quarter-wave cavity for the New Delhi booster linac

    International Nuclear Information System (INIS)

    Shepard, K.W.; Roy, A.; Potukuchi, P.N.

    1997-01-01

    This paper reports the completion of development of a 97 Mhz niobium coaxial quarter-wave cavity to be used in a booster linac for the New Delhi 16UD pellatron electrostatic accelerator. A prototype cavity, which incorporates a niobium-bellows tuning device, has been completed and operated at 4.2 K at accelerating gradients above 4 MV/m for extended periods of time

  3. Center frequency shift and reduction of feedback in directly modulated external cavity lasers

    DEFF Research Database (Denmark)

    Schiellerup, G.; Pedersen, Rune Johan Skullerud; Olesen, H.

    1989-01-01

    It is shown experimentally and theoretically that a center frequency shift occurs when an external cavity laser is directly modulated. The shift can be observed even when the frequency deviation is small compared to the roundtrip frequency of the external cavity and can qualitatively be explained...... by a reduction in the effective feedback level due to modulation. The frequency shift was measured as a function of modulation frequency and current, and frequency shifts up to 350 MHz were observed...

  4. Niobium quarter-wave cavity for the New Delhi booster linac

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, K.W. [Argonne National Lab., IL (United States); Roy, A.; Potukuchi, P.N. [Nuclear Science Centre, New Delhi (India)

    1997-09-01

    This paper reports the completion of development of a 97 Mhz niobium coaxial quarter-wave cavity to be used in a booster linac for the New Delhi 16UD pellatron electrostatic accelerator. A prototype cavity, which incorporates a niobium-bellows tuning device, has been completed and operated at 4.2 K at accelerating gradients above 4 MV/m for extended periods of time.

  5. Frequency Arrangement For 700 MHz Band

    Directory of Open Access Journals (Sweden)

    Ancans G.

    2015-02-01

    Full Text Available The 694-790 MHz (700 MHz band was allocated by the 2012 World Radiocommunication Conference (WRC-12 in ITU Region 1 (Europe included, to the mobile service on a co-primary basis with other services to which this band was allocated on the primary basis and identified for the International Mobile Telecommunications (IMT. At the same time, the countries of Region 1 will be able also to continue using these frequencies for their broadcasting services if necessary. This allocation will be effective immediately after 2015 World Radiocommunication Conference (WRC-15. In order to make the best possible use of this frequency band for mobile service, a worldwide harmonized frequency arrangement is to be prepared to allow for large economies of scale and international roaming as well as utilizing the available spectrum in the best possible way, minimizing possible interference between services, facilitating deployment and cross-border coordination. The authors analyze different possible frequency arrangements and conclude on the frequency arrangement most suitable for Europe.

  6. Assessment of Temperament and Character Profile with Anxiety and Depression in Patients with Acne

    Directory of Open Access Journals (Sweden)

    Perihan Öztürk

    2013-06-01

    Full Text Available Background: Acne is the most common skin disease, affecting nearly 85% of the population as well as their lives. Acne can severely affect social and psychological functioning. Patients with acne may have anxiety, depression, decreased self-esteem, interpersonal difficulties, unemployment, social withdrawal, and even suicidal intent. Aims: The aim of this study was to evaluate the temperament and character inventory (TCI of patients with acne and to compare the results with those of healthy controls. Study Design: Case-control study Methods: The study population consisted of 47 patients with acne, and 40 healthy control subjects. All participants were instructed to complete a self-administered 240-item TCI and the Hospital Anxiety and Depression Scale. Results: In this study, the scores for the temperament properties Worry and pessimism (HA1 and Dependence (RD4 and the character properties Social acceptance (C1 and Integrated conscience (C5 were found to be higher in acne patients than in healthy controls (p<0.05. Compared to the controls, depression and anxiety scores were found to be markedly higher in the patients with acne. Acne type correlated positively with the Disorderliness (NS4 subscale of Novelty seeking (NS and anxiety. Additionally, acne type correlated negatively with the Attachment (RD3 subscale of Reward Dependence (RD, with the Transpersonal identification (ST2 and Spiritual acceptance (ST3 subscales of Self-Trancendence (ST, and with the Compassion (C4 subscale of Cooperativeness (C. Conclusion: Studies in this area may lead to the development of specific and focused interventions for TCI in patients with acne vulgaris. We suggest that the evaluation and treatment of acne should also include psychosomatic approaches in clinical practice.

  7. Tissue Liver X-Receptor Alpha (LXRα) Level In Acne Vulgaris

    International Nuclear Information System (INIS)

    Nada, E.A.A.

    2012-01-01

    Acne vulgaris is a disease of the pilosebaceous unit. Increased sebum lipogenesis by sebaceous gland is the major factor in the pathophysiology of acne. LXRα have been recognized in the regulation of genes involved in lipid biosynthesis. Activation of LXRα inhibits proliferation, increase lipogenesis and improve differentiation of sebocytes. Aim: To investigate the level of tissue expression of LXRα in inflammatory and non inflammatory acne lesions and in comparison with normal skin. Patients and methods: Seventeen patients with inflammatory and non inflammatory acne lesions and sixteen age and sex comparable healthy volunteers as control were included in the study. Punch skin biopsies were taken from the acne lesions and normal skin of the volunteers for detection of gene expression of LXRα by RT- PCR. Results: the level of LXRα was significantly higher in the lesional skin either inflammatory (with a mean of 1188.52 ± 129.5) or comedonal acne (with a mean of 892.52 ± 66.08) in a statistically significant manner than the controls (with a mean of 600.50 ± 95.30) where the P value was <0.001. In addition, the level of LXRα was significantly higher in inflammatory acne (with a mean of 1188.52 ± 129.5) in a statistically significant manner) than comedonal acne (with a mean of 892.52 ± 66.08) where the P value was <0.001. Conclusion: the significant increase in the level of LXRα in acne lesions compared to controls suggesting that LXRα may have a role in the pathogenesis of acne vulgaris itself and is not a consequence of inflammation. In addition, it may play a role in the progression of the disease from comedonal to inflammatory. Further studies are recommended to evaluate the therapeutic benefits of the use of LXRα antagonists as a new therapeutic modality for acne vulgaris.

  8. The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris.

    Science.gov (United States)

    Hoffman, Lauren K; Del Rosso, James Q; Kircik, Leon H

    2017-06-01

    INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne. STUDY DESIGN: A single-center, open label pilot study was conducted to investigate the efficacy and safety of azelaic acid 15% foam as a treatment modality for moderate truncal acne. Use for facial acne was also allowed and monitored during the study. RESULTS: Twice-daily application of azelaic acid 15% foam to affected areas resulted in a 1-grade reduction in truncal investigator global assessment (IGA) scores in nearly all patients (16/18). Eight out of 18 patients (44%) were rated as Clear or Almost Clear in the trunk by the end of the study. There were also improvements in facial IGA scores; 9 of 18 patients (50%) exhibited a 1-grade improvement in IGA scores and 11 of 18 were Clear or Almost Clear by the end of the study. A significant reduction in lesion counts was found throughout the study and the medication was well tolerated. CONCUSION: Azelaic acid 15% foam was effective in treating moderate truncal acne and facial acne in this pilot study. Given the efficacy and convenience of the foam vehicle, azelaic acid may be considered as a viable option for treatment of acne vulgaris, including on the trunk. Further studies are suggested in a larger population of patients, including adult females with acne. J Drugs Dermatol. 2017;16(6):534-538..

  9. Cavity design programs

    International Nuclear Information System (INIS)

    Nelson, E.M.

    1996-01-01

    Numerous computer programs are available to help accelerator physicists and engineers model and design accelerator cavities and other microwave components. This article discusses the problems these programs solve and the principles upon which these programs are based. Some examples of how these programs are used in the design of accelerator cavities are also given

  10. Cavity quantum electrodynamics

    International Nuclear Information System (INIS)

    Walther, Herbert; Varcoe, Benjamin T H; Englert, Berthold-Georg; Becker, Thomas

    2006-01-01

    This paper reviews the work on cavity quantum electrodynamics of free atoms. In recent years, cavity experiments have also been conducted on a variety of solid-state systems resulting in many interesting applications, of which microlasers, photon bandgap structures and quantum dot structures in cavities are outstanding examples. Although these phenomena and systems are very interesting, discussion is limited here to free atoms and mostly single atoms because these systems exhibit clean quantum phenomena and are not disturbed by a variety of other effects. At the centre of our review is the work on the one-atom maser, but we also give a survey of the entire field, using free atoms in order to show the large variety of problems dealt with. The cavity interaction can be separated into two main regimes: the weak coupling in cavity or cavity-like structures with low quality factors Q and the strong coupling when high-Q cavities are involved. The weak coupling leads to modification of spontaneous transitions and level shifts, whereas the strong coupling enables one to observe a periodic exchange of photons between atoms and the radiation field. In this case, atoms and photons are entangled, this being the basis for a variety of phenomena observed, some of them leading to interesting applications in quantum information processing. The cavity experiments with free atoms reached a new domain with the advent of experiments in the visible spectral region. A review on recent achievements in this area is also given

  11. Quality of life measurement in acne. Position Paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

    NARCIS (Netherlands)

    Chernyshov, P. V.; Zouboulis, C. C.; Tomas-Aragones, L.; Jemec, G. B.; Manolache, L.; Tzellos, T.; Sampogna, F.; Evers, A. W. M.; Dessinioti, C.; Marron, S. E.; Bettoli, V.; van Cranenburgh, O. D.; Svensson, A.; Liakou, A. I.; Poot, F.; Szepietowski, J. C.; Salek, M. S.; Finlay, A. Y.

    2018-01-01

    Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in

  12. Harmonic Kicker RF Cavity for the Jefferson Lab Electron-Ion Collider EM Simulation, Modification, and Measurements

    Science.gov (United States)

    Overstreet, Sarah; Wang, Haipeng

    2017-09-01

    An important step in the conceptual design for the future Jefferson Lab Electron-Ion Collider (JLEIC) is the development of supporting technologies for the Energy Recovery Linac (ERL) Electron Cooling Facility. The Harmonic Radiofrequency (RF) kicker cavity is one such device that is responsible for switching electron bunches in and out of the Circulator Cooling Ring (CCR) from and to the ERL, which is a critical part of the ion cooling process. Last year, a half scale prototype of the JLEIC harmonic RF kicker model was designed with resonant frequencies to support the summation of 5 odd harmonics (95.26 MHz, 285.78 MHz, 476.30 MHz, 666.82 MHz, and 857.35 MHz); however, the asymmetry of the kicker cavity gives rise to multipole components of the electric field at the electron-beam axis of the cavity. Previous attempts to symmetrize the electric field of this asymmetrical RF cavity have been unsuccessful. The aim of this study is to modify the existing prototype for a uniform electric field across the beam pathway so that the electron bunches will experience nearly zero beam current loading. In addition to this, we have driven the unmodified cavity with the harmonic sum and used the wire stretching method for an analysis of the multipole electric field components.

  13. Formation of coronal cavities

    International Nuclear Information System (INIS)

    An, C.H.; Suess, S.T.; Tandberg-Hanssen, E.; Steinolfson, R.S.

    1986-01-01

    A theoretical study of the formation of a coronal cavity and its relation to a quiescent prominence is presented. It is argued that the formation of a cavity is initiated by the condensation of plasma which is trapped by the coronal magnetic field in a closed streamer and which then flows down to the chromosphere along the field lines due to lack of stable magnetic support against gravity. The existence of a coronal cavity depends on the coronal magnetic field strength; with low strength, the plasma density is not high enough for condensation to occur. Furthermore, we suggest that prominence and cavity material is supplied from the chromospheric level. Whether a coronal cavity and a prominence coexist depends on the magnetic field configuration; a prominence requires stable magnetic support

  14. 47 CFR 101.69 - Transition of the 1850-1990 MHz, 2110-2150 MHz, and 2160-2200 MHz bands from the fixed microwave...

    Science.gov (United States)

    2010-10-01

    ..., and 2160-2200 MHz bands from the fixed microwave services to personal communications services and...) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Applications and Licenses License Transfers... MHz bands from the fixed microwave services to personal communications services and emerging...

  15. The PS 13.3-20 MHZ RF Systems for LHC

    CERN Document Server

    Garoby, R; Haase, M; Krusche, A; Maesen, P; Morvillo, M; Paoluzzi, M; Rossi, C

    2003-01-01

    As part of the preparation of the PS as an injector for the LHC, a prototype 20 MHz rf system has been used, to demonstrate that the nominal longitudinal performance of the proton beam for LHC can be obtained using multiple bunch-splittings. Based on these successful results obtained during 2000, the development of the operational rf system began in 2001. To allow the preparation of bunch trains with a bunch spacing of 25 or 75 ns, this system must operate either at 20 or 13.3 MHz respectively. Two new ferrite cavities and their associated amplifiers have been designed and built. Each one can provide a maximum voltage of 20 kV peak during 200 ms with a 10% duty cycle. The cavities are equipped with fast (~20 ms) gap shorting relays, and rf feedback reduces their Q below 10 at both frequencies. A single system is sufficient to generate the nominal beam for LHC. The second one will then be both a "hot spare" and a very valuable performance enhancement providing the possibility of handling a larger than nominal ...

  16. Draft Genome Sequences of Two Propionibacterium acnes Strains Isolated from Progressive Macular Hypomelanosis Lesions of Human Skin

    DEFF Research Database (Denmark)

    Petersen, Rolf; Lomholt, Hans B.; Scholz, Christian F. P.

    2015-01-01

    Propionibacterium acnes is a Gram-positive bacterium that is prevalent on human skin. It has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (PMH). Here, we report draft genome sequences of two type III P. acnes strains, PMH5 and PMH7, isolated from...

  17. Application of International Linear Collider superconducting cavities for acceleration of protons

    Directory of Open Access Journals (Sweden)

    P. N. Ostroumov

    2007-12-01

    Full Text Available Beam acceleration in the International Linear Collider (ILC will be provided by 9-cell 1300 MHz superconducting (SC cavities. The cavities are designed for effective acceleration of charged particles moving with the speed of light and are operated on π-mode to provide a maximum accelerating gradient. A significant research and development effort has been devoted to develop ILC SC technology and its rf system which resulted in excellent performance of ILC cavities. Therefore, the proposed 8-GeV proton driver in Fermilab is based on ILC cavities above ∼1.2  GeV. The efficiency of proton beam acceleration by ILC cavities drops fast for lower velocities and it was proposed to develop squeezed ILC-type (S-ILC cavities operating at 1300 MHz and designed for β_{G}=0.81, geometrical beta, to accelerate protons or H^{-} from ∼420  MeV to 1.2 GeV. This paper discusses the possibility of avoiding the development of new β_{G}=0.81 cavities by operating ILC cavities on 8/9π-mode of standing wave oscillations.

  18. Fluorescence digital photography of acne using a light-emitting diode illuminator.

    Science.gov (United States)

    Ahn, Hyo Hyun; Kim, Soo Nam; Kye, Young Chul

    2006-11-01

    The fluorescence findings of several dermatological diseases, such as erythrasma, tinea versicolor, and acne are helpful for diagnosis and follow-up. However, many experience difficulty taking photographic images of fluorescence. The aim of this study was to develop a 405 nm light-emitting diode (LED) system for fluorescence digital photography of acne and to determine whether such a diode can be used to evaluate acne. Eight healthy acne patients were compared with controls by fluorescence digital photography using a digital camera equipped with a 405 nm LED illuminator. Digital photographs were taken by two different ways of exposure, i.e. appropriate exposure level and longer exposure. One side of the nose, cheek, and glabella was compared. The numbers and extents of fluorescence dots were counted and measured. As normal controls, seven individuals with apparent oiliness and no acne were enrolled. Red fluorescent facial dots were observed and photographed digitally using the 405 nm LED illuminator. These were more numerous and extensive on the glabella and cheeks of acne patients. Fluorescence digital photography of acne was successfully performed using a 405 nm LED illuminator. This illuminator could be used for acne evaluations.

  19. Formulation and characterization of solid lipid nanoparticles loaded Neem oil for topical treatment of acne

    Directory of Open Access Journals (Sweden)

    V. Vijayan

    2013-01-01

    Conclusion: The result concluded that Neem oil loaded solid lipid nanoparticles with more lecithin content in their colloid exhibit sustained effect which satisfactorily produced the antibacterial action on Acne microbes. Therefore Neem oil loaded SLN was used successfully for prolonged treatment of Acne.

  20. Quality of life in acne vulgaris: Relationship to clinical severity and demographic data.

    Science.gov (United States)

    Gupta, Aayush; Sharma, Yugal Kishor; Dash, Kedar Nath; Chaudhari, Nitin Dinkar; Jethani, Sumit

    2016-01-01

    Acne vulgaris is known to impair many aspects of quality of life. However, the correlation of this impairment with clinical severity remains equivocal despite various school, community and hospital-based studies. A hospital-based study was undertaken to measure the impairment of quality of life of patients of acne vulgaris and correlate it with the severity of lesions. This was a cross-sectional, questionnaire-based study in a cohort of 100 patients of acne vulgaris attending the outpatient department of our referral hospital. A physician measured the severity of lesions using the global acne grading system, and patients assessed quality of life by completing a questionnaire (Cardiff acne disability index). A correlation of these two was done; some additional correlations were brought out through demographic data collected from the patients. There was no correlation between the severity of acne vulgaris and an impaired quality of life. Patients who consumed alcohol and/or smoked cigarettes were found to have an impaired quality of life. While the severity of acne progressively lessened in older patients, the impact on quality of life increased. The sample size was small and there was a lack of guaranteed reliability on the self-reported quality of life. The severity of acne vulgaris does not correlate with impairment in quality of life.

  1. Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris.

    Science.gov (United States)

    Lee, Kyung Real; Lee, Eo Gin; Lee, Hee Jung; Yoon, Moon Soo

    2013-12-01

    A minimally invasive fractional radiofrequency microneedle (FRM) device has been used in skin rejuvenation and acne scars, and a recent pilot study demonstrated the positive therapeutic effect on acne. We evaluated the efficacy of FRM device for acne vulgaris in Asians and conducted objective measurement to assess its effect on sebum production. Twenty Korean patients with acne vulgaris received a single full-face FRM treatment. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, acne lesion count, and objective measurements of casual sebum level (CSL) and sebum excretion rate (SER). They were evaluated at baseline and 2, 4, 8 weeks after the treatment. After a single FRM treatment, the CSL and the SER showed 30-60% and 70-80% reduction, respectively, at week 2 (P acne severity and acne lesion count also revealed clinical improvement with maximum efficacy at week 2, but returned to the baseline in most patients by week 8. Patients' satisfaction scores (0-4) were above 2 on average, and adverse effects were minimal. This prospective study demonstrated the sebosuppressive effect from a single FRM treatment, but its therapeutic efficacy in acne requires further evaluation. © 2013 Wiley Periodicals, Inc.

  2. Management of acne vulgaris with hormonal therapies in adult female patients.

    Science.gov (United States)

    Husein-ElAhmed, Husein

    2015-01-01

    Acne vulgaris is a very common condition affecting up of 93% of adolescents. Although rare, this disease may persist in adulthood. In adult women with acne (those older than 25 years old), this condition is particularly relevant because of the refractory to conventional therapies, which makes acne a challenge for dermatologists in this group of patients. In order to its potential risk for chronicity and the involvement of visible anatomical sites such as face and upper torso, acne has been associated with a wide spectrum of psychological and social dysfunction such as depression, anxiety, suicidal ideation, somatization, and social inhibition. In particular, adult women with acne have been shown to be adversely impacted by the effect of acne on their quality of life. For the last four decades, dermatologists have used hormonal therapies for the management of acne vulgaris in adult women, which are considered a rational choice given the severity and chronicity of this condition in this group of patients. The aim of this work is to review the hormonal drugs for management of acne. © 2015 Wiley Periodicals, Inc.

  3. The influence of united psychosomatic factors on clinical features of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Dejanović Lidija

    2014-01-01

    Full Text Available Acne is a chronic inflammatory disorder of the pilosebaceal unit. Dermatological disorders are often associated with a variety of psychological problems which the patient have. Psichodermatologic disorders (acne are associated with skin problems that are not directly connected to the mind, but that react to emotional states, such as stress. The aim of this article is to show if there is any psychological characteristic which are common for the whole group of ill-patients from acne, as well as whether there is correlation between any type of acne and psychological parameters. Own exploration consist at thirty patients with three clinical type of acne. Personality test-Kornel index were used for identification and diagnostic psychosomatic disorders. The results are: neurastenic parameters, parameters of conversion and parameters of psychopathy in different percent at both sex, and different clinical features. We show correlation united 2-6 psichosomatic disorders in male sex with softly type of acne. In female sex with any type of acne are responsible 7-12 united findings. The association of several psychosomatic factors could possibly be responsible for the onset of acne at any type.

  4. Evaluation of microneedling fractional radiofrequency device for treatment of acne scars

    Directory of Open Access Journals (Sweden)

    Byalekere Shivanna Chandrashekar

    2014-01-01

    Full Text Available Background: Various treatment modalities including non-invasive methods such as chemical peels, topical retinoids, microdermabrasion, minimally invasive techniques such as microneedling, fractional lasers, microneedling radiofrequency devices and invasive procedures such as acne scar surgeries and ablative lasers are used for acne scars, each with its own unique advantages and disadvantages. This study is a retrospective assessment of efficacy and safety of microneedling fractional radiofrequency in the treatment of acne scars. Methods: Thirty one patients of skin types III-V with moderate and severe facial acne scarring received four sequential fractional radiofrequency treatments over a period of 6 months with an interval of 6 weeks between each session. Goodman & Baron′s acne scar grading system was used for assessment by a side by side comparison of preoperative and post- operative photographs taken at their first visit and at the end of 3 months after the last session. Results: Estimation of improvement with Goodman and Baron′s Global Acne Scarring System showed that by qualitative assessment of 31 patients with grade 3 and grade 4 acne scars, 80.64% showed improvement by 2 grades and 19.35% showed improvement by 1 grade. Quantitative assessment showed that 58% of the patients had moderate, 29% had minimal, 9% had good and 3% showed very good improvement. Adverse effects were limited to transient pain, erythema, edema and hyperpigmentation. Conclusion: Microneedling fractional radiofrequency is efficacious for the treatment of moderate and severe acne scars.

  5. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria.

    Science.gov (United States)

    Chomnawang, Mullika Traidej; Surassmo, Suvimol; Nukoolkarn, Veena S; Gritsanapan, Wandee

    2005-10-03

    Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Thai medicinal plants against these etiologic agents of acne vulgaris. Crude extracts were tested for antimicrobial activities by disc diffusion and broth dilution methods. The results from the disc diffusion method showed that 13 medicinal plants could inhibit the growth of Propionibacterium acnes. Among those, Senna alata, Eupatorium odoratum, Garcinia mangostana, and Barleria lupulina had strong inhibitory effects. Based on a broth dilution method, the Garcinia mangostana extract had the greatest antimicrobial effect. The MIC values were the same (0.039 mg/ml) for both bacterial species and the MBC values were 0.039 and 0.156 mg/ml against Propionibacterium acnes and Staphylococcus epidermidis, respectively. In bioautography assay, the Garcinia mangostana extract produced strong inhibition zones against Propionibacterium acnes. Antimicrobial activity from fractions of column chromatography revealed one of the active compounds in Garcinia mangostana could be mangostin, a xanthone derivative. Taken together, our data indicated that Garcinia mangostana had a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis. Therefore, this plant would be an interesting topic for further study and possibly for an alternative treatment for acne.

  6. Acne severity grading: determining essential clinical components and features using a Delphi consensus.

    Science.gov (United States)

    Tan, Jerry; Wolfe, Barat; Weiss, Jonathan; Stein-Gold, Linda; Bikowski, Joseph; Del Rosso, James; Webster, Guy F; Lucky, Anne; Thiboutot, Diane; Wilkin, Jonathan; Leyden, James; Chren, Mary-Margaret

    2012-08-01

    There are multiple global scales for acne severity grading but no singular standard. Our objective was to determine the essential clinical components (content items) and features (property-related items) for an acne global grading scale for use in research and clinical practice using an iterative method, the Delphi process. Ten acne experts were invited to participate in a Web-based Delphi survey comprising 3 iterative rounds of questions. In round 1, the experts identified the following clinical components (primary acne lesions, number of lesions, extent, regional involvement, secondary lesions, and patient experiences) and features (clinimetric properties, ease of use, categorization of severity based on photographs or text, and acceptance by all stakeholders). In round 2, consensus for inclusion in the scale was established for primary lesions, number, sites, and extent; as well as clinimetric properties and ease of use. In round 3, consensus for inclusion was further established for categorization and acceptance. Patient experiences were excluded and no consensus was achieved for secondary lesions. The Delphi panel consisted solely of the United States (U.S.)-based acne experts. Using an established method for achieving consensus, experts in acne vulgaris concluded that an ideal acne global grading scale would comprise the essential clinical components of primary acne lesions, their quantity, extent, and facial and extrafacial sites of involvement; with features of clinimetric properties, categorization, efficiency, and acceptance. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  7. A review of Acne Keloidalis Nuchae At The University of Nigeria ...

    African Journals Online (AJOL)

    Aim: To determine the profile of acne keloidilis nuchae among Nigerians and to document the various treatment modalities undertaken by these patients prior to presentation at our dermatology clinic. Patient and Methods: A retrospective study of patients with acne keloidalis nuchae (AKN) at the University of Nigeria ...

  8. The constellation of dietary factors in adolescent acne: a semantic connectivity map approach.

    Science.gov (United States)

    Grossi, E; Cazzaniga, S; Crotti, S; Naldi, L; Di Landro, A; Ingordo, V; Cusano, F; Atzori, L; Tripodi Cutrì, F; Musumeci, M L; Pezzarossa, E; Bettoli, V; Caproni, M; Bonci, A

    2016-01-01

    Different lifestyle and dietetic factors have been linked with the onset and severity of acne. To assess the complex interconnection between dietetic variables and acne. This was a reanalysis of data from a case-control study by using a semantic connectivity map approach. 563 subjects, aged 10-24 years, involved in a case-control study of acne between March 2009 and February 2010, were considered in this study. The analysis evaluated the link between a moderate to severe acne and anthropometric variables, family history and dietetic factors. Analyses were conducted by relying on an artificial adaptive system, the Auto Semantic Connectivity Map (AutoCM). The AutoCM map showed that moderate-severe acne was closely associated with family history of acne in first degree relatives, obesity (BMI ≥ 30), and high consumption of milk, in particular skim milk, cheese/yogurt, sweets/cakes, chocolate, and a low consumption of fish, and limited intake of fruits/vegetables. Our analyses confirm the link between several dietetic items and acne. When providing care, dermatologists should also be aware of the complex interconnection between dietetic factors and acne. © 2014 European Academy of Dermatology and Venereology.

  9. Treatment of Active Acne Vulgaris by Chemical Peeling Using 88% Lactic Acid

    Directory of Open Access Journals (Sweden)

    Khalifa E. Sharquie

    2014-10-01

    Full Text Available Introduction: The etiopathogenesis of acne vulgaris is multifactorial, and its therapy is prolonged course that might be not accepted by many patients. Most recently TCA 35% one session peeling gave complete clearance and full remission for active acne vulgaris. Lactic acid has been used effectively as therapeutic topical agents for many skin diseases. Aim: To evaluate the efficacy and safety of chemical peeling using 88% lactic acid solution in the treatment of active acne vulgaris. Material and Methods: This clinical, interventional, therapeutic study was done at the Department of Dermatology, Baghdad Teaching Hospital, during the period from October 2012 to October 2013. Twenty five patients with active acne vulgaris were included, 15 (60% females and 10 (40% males and their ages ranged from 16-36 (21.5000± 5.46279 years. Fifteen patients were associated with acne scars. Three chemical peels using 88% lactic acid solution was carried out two weeks apart for patients with active acne vulgaris with or without scarring. Scoring for active acne vulgaris and acne scar was done for each case before and after operation to evaluate the severity of acne and the degree of scar before and after treatment. All patients were with Fitzpatrick’s skin types III and IV. Patients were followed up every two weeks during period of therapy and monthly for 3 months after stopping the treatment. Results: Twenty five patients with active acne vulgaris were treated with 3 sessions of lactic acid, fifteen patients had associated acne scar. Scoring for active acne vulgaris including papules and pustules showed highly statistically significant reduction after 2 weeks of therapy (p=0.0001, after 4 weeks (p=0.0001and after 6 weeks (p=0.0001, with percent reduction 87.2% for papules and 94% for pustules after end of sessions while after 3 months follow up the reduction rate for papules 93.8% and p-value (p=0.001 and for pustules 97.6% and (p=0.0001. While the scarring

  10. Epidemiology of acne vulgaris in adolescent male students in Arar, Kingdom of Saudi Arabia.

    Science.gov (United States)

    Abo El-Fetoh, Nagah M; Alenezi, Naif G; Alshamari, Nasser G; Alenezi, Omar G

    2016-09-01

    Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Small, noninflamed acne lesions may not be more than a slight nuisance, but, in individuals with more severe inflammatory disease, pain, social embarrassment, and both physical and psychological scarring can be life altering. Despite its high prevalence, no previous community-based studies have been conducted in Arar, northern border of Kingdom of Saudi Arabia, addressing this issue. The aim of this study was to estimate the prevalence of acne vulgaris, to describe the sociodemographic characteristics of cases, and to determine the aggravating factors and the psychological impact of acne vulgaris in a representative sample of secondary school male students in Arar city, Kingdom of Saudi Arabia. This was a cross-sectional study. A multistage systematic random sampling technique was followed. A total of 400 male students during the academic year 2015-2016 were included in the study. Data were collected by means of personal interview and filling-in a questionnaire. The overall prevalence of acne vulgaris was 53.5%. The mean age of onset was 15.0±1.2 years. Positive family history of acne vulgaris was found in 46.7% of cases. The skin was greasy in 61.7% of cases. Acne site was the face in 67.3%, the back in 4.7%, and both in 28% of the cases. More than half (54.2%) of the cases had first-degree acne. Students mentioned several factors affecting the appearance of acne; 59.8% of cases reported a relation of increased acne appearance with the cleanliness of the skin, 35.5% reported relation with consumption of fatty meals, 24.2% with eating chocolate, 23.3% with consumption of spicy food, 12.1% with excess intake of cola drinks, 31.8% with heavy smoking, and 60.7% reported increased acne appearance in summer months. Acne was highly prevalent among secondary school male students in Arar city, Kingdom of Saudi Arabia. Several risk factors increased the appearance of acne, including

  11. The all-sky 408 MHz survey

    International Nuclear Information System (INIS)

    Haslam, C.G.T.; Salter, C.J.; Stoffel, H.

    1981-01-01

    A brief outline of the results of this survey is presented. The 408 MHz All-sky Survey has been made from four radio continuum surveys observed between 1965 and 1978, using the Jodrell Bank MKI telescope (Haslam et al., 1970), the Effelsberg 100 metre telescope (Haslam et al., 1974) and the Parkes 64 metre telescope (Haslam et al., 1975). A detailed description of the survey data reduction and calibration methods, with preliminary astronomical results will soon be published (Haslam et al., 1980a) and a second paper will give an atlas of maps at the full survey resolution of 51' arc between half power points (Haslam et al., 1980b). A map, smoothed to a gaussian beam with resolution between half power poitns of 3 0 , is presented. (Auth.)

  12. Incidence of Propionibacterium acnes in initially culture-negative thioglycollate broths

    DEFF Research Database (Denmark)

    Kvich, L.; Jensen, Peter Østrup; Justesen, U. S.

    2016-01-01

    The aim of this study was to prospectively investigate the incidence of Propionibacterium acnes in thioglycollate broths reported as culture-negative at the Department of Clinical Microbiology, Rigshospitalet, to evaluate whether 5 days of incubation was enough to find all relevant cases. Five....... After exclusion criteria were met, P. acnes was cultured from ten out of 151 patients (6.6%) in the infected group and from one out of 138 participants (0.7%) in the control group. This resulted in more findings of P. acnes in the infected group on day 14 than on day 5 (p 0.002). Furthermore, P. acnes...... was cultured more often from bone tissue and tissue surrounding foreign materials on day 14 than on day 5 (p 0.04). Clinical microbiology laboratories should consider incubating thioglycollate broths for at least 14 days to find all relevant cases of P. acnes, especially when it comes to bone tissue and tissue...

  13. Exploring the relationship between stress and acne: a medical student’s perspective

    Directory of Open Access Journals (Sweden)

    Maleki A

    2018-04-01

    Full Text Available Aryan Maleki, Noorulain Khalid Faculty of Medicine, Barts and The London School of Medicine and Dentistry, London, UKWe read with great interest the paper by Zari and Alrahmani1 investigating the relationship between stress and acne among female medical students. These findings are relevant as around 20% of young people are affected by moderate-to-severe acne, and indeed acne severity is associated with increased risks of anxiety, depression and suicidal ideation.2 The authors identified that “stress severity strongly correlated with an increase in acne severity,” and suggested that stress likely has an important role in the pathogenesis of acne.1 However, the paper could have been taken further to better establish the true extent of this relationship, and ultimately whether certain patients will benefit from clinical interventions based on their perceived stress scale. View the original paper by Zari and Alrahmani.

  14. The Skin Bacterium Propionibacterium acnes Employs Two Variants of Hyaluronate Lyase with Distinct Properties

    DEFF Research Database (Denmark)

    Nazipi, Seven; Stødkilde-Jørgensen, Kristian; Scavenius, Carsten

    2017-01-01

    Hyaluronic acid (HA) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. One of the most prevalent skin microorganisms, Propionibacterium acnes, possesses HA-degrading activity, possibly conferred by the enzyme hyaluronate lyase (HYL). In this study......, we identified the HYL of P. acnes and investigated the genotypic and phenotypic characteristics. Investigations include the generation of a P. acneshyl knockout mutant and HYL activity assays to determine the substrate range and formed products. We found that P. acnes employs two distinct variants...... of the observed differences between P. acnes phylotype IA and IB/II strains. Whereas type IA strains are primarily found on the skin surface and associated with acne vulgaris, type IB/II strains are more often associated with soft and deep tissue infections, which would require elaborate tissue invasion...

  15. [Physical treatment methods for acne. Light, laser, photodynamic therapy and peeling].

    Science.gov (United States)

    Borelli, C; Korting, H C

    2010-02-01

    The medical treatment of acne is generally sufficient to meet the expectations of acne patients. However, in a number of situations additional therapeutic approaches may be advisable. There are a wide variety of useful physical methods. They range from electromagnetic waves, usually light, to peeling and manual therapy. Phototherapy of acne includes not just visible light but also laser and flash lamp therapy. The present review provides an overview on the evidence. Visible light, in particular blue light, provides an effective option for treatment of inflammatory acne. Photodynamic therapy also is efficacious; however, it should not be used because of an unfavorable risk-benefit ratio. UV treatment of acne is obsolete. Newer studies on the use of a variety of laser systems and flash lamps have demonstrated in part rewarding results.

  16. Cheilitis in acne vulgaris patients with no previous use of systemic retinoid products.

    Science.gov (United States)

    Balighi, Kamran; Daneshpazhooh, Maryam; Lajevardi, Vahideh; Talebi, Shahin; Azizpour, Arghavan

    2017-08-01

    Isotretinoin is commonly used in the treatment of acne vulgaris. While one of the more common side-effects is cheilitis, we have observed an increased incidence of cheilitis prior to the commencement of systemic isotretinoin. The aim of this study was to assess the prevalence of cheilitis among acne vulgaris patients. A non-interventional cross-sectional study of patients with acne vulgaris. Patients with previous use of systemic retinoids were excluded. The patients were examined for signs and symptoms of cheilitis. Of a total of 400 patients, 134 (34%) had evidence of cheilitis at initial presentation. Two-thirds (63%) were female (P acne excorie, compared with only 8% of patients with no signs of cheilitis. Our findings suggest that cheilitis is quite common among acne vulgaris patients even before treatment with isotretinoin. © 2016 The Australasian College of Dermatologists.

  17. C1-C2 arthrodesis after spontaneous Propionibacterium acnes spondylodiscitis: Case report and literature analysis

    Science.gov (United States)

    di Russo, Paolo; Tascini, Carlo; Benini, Maria Elena; Martini, Carlotta; Lepori, Paolo

    2018-01-01

    Background: Propionibacterium acnes (P. acnes) is a microaerophilic anaerobic Gram-positive rod responsible for acne vulgaris. Although it is often considered to be a skin contaminant, it may act as a virulent agent in implant-associated infections. Conversely, spontaneous infectious processes have been rarely described. Case Description: Here, we describe a 43-year-old female with C1-C2 spondylodiscitis attributed to P. acnes infection. Despite long-term antibiotic treatment, computed tomography demonstrated erosion of the C1 and C2 vertebral complex that later warranted a fusion. One year postoperatively, the patient was asymptomatic. Conclusions: Clinical knowledge of P. acnes virulence in spontaneous cervical spondylodiscitis allows early diagnosis, which is necessary to prevent or reduce complications such as cervical deformity with myelopathy or mediastinitis. PMID:29497567

  18. Superconducting TESLA cavities

    Directory of Open Access Journals (Sweden)

    B. Aune

    2000-09-01

    Full Text Available The conceptional design of the proposed linear electron-positron collider TESLA is based on 9-cell 1.3 GHz superconducting niobium cavities with an accelerating gradient of E_{acc}≥25 MV/m at a quality factor Q_{0}≥5×10^{9}. The design goal for the cavities of the TESLA Test Facility (TTF linac was set to the more moderate value of E_{acc}≥15 MV/m. In a first series of 27 industrially produced TTF cavities the average gradient at Q_{0}=5×10^{9} was measured to be 20.1±6.2 MV/m, excluding a few cavities suffering from serious fabrication or material defects. In the second production of 24 TTF cavities, additional quality control measures were introduced, in particular, an eddy-current scan to eliminate niobium sheets with foreign material inclusions and stringent prescriptions for carrying out the electron-beam welds. The average gradient of these cavities at Q_{0}=5×10^{9} amounts to 25.0±3.2 MV/m with the exception of one cavity suffering from a weld defect. Hence only a moderate improvement in production and preparation techniques will be needed to meet the ambitious TESLA goal with an adequate safety margin. In this paper we present a detailed description of the design, fabrication, and preparation of the TESLA Test Facility cavities and their associated components and report on cavity performance in test cryostats and with electron beam in the TTF linac. The ongoing research and development towards higher gradients is briefly addressed.

  19. Cooling the APS storage ring radio-frequency accelerating cavities: Thermal/stress/fatigue analysis and cavity cooling configuration

    International Nuclear Information System (INIS)

    Primdahl, K.; Kustom, R.

    1995-01-01

    The 7-GeV Advanced Photon Source positron storage ring requires sixteen separate 352-MHz radio-frequency (rf) accelerating cavities. Cavities are installed as groups of four, in straight sections used elsewhere for insertion devices. They occupy the first such straight section after injection, along with the last three just before injection. Cooling is provided by a subsystem of the sitewide deionized water system. Pumping equipment is located in a building directly adjacent to the accelerator enclosure. A prototype cavity was fabricated and tested where cooling was via twelve 19-mm-diameter [3/4 in] brazed-on tubes in a series-parallel flow configuration. Unfortunately, the thermal contact to some tubes was poor due to inadequate braze filler. Here, heat transfer studies, including finite-element analysis and test results, of the Advanced Photon Source (APS) storage ring 352-MHz rf accelerating cavities are described. Stress and fatigue life of the copper are discussed. Configuration of water cooling is presented

  20. RF Processing of the Couplers for the SNS Superconducting Cavities

    International Nuclear Information System (INIS)

    Y.Kang; I.E. Campisi; D. Stout; A. Vassioutchenko; M. Stirbet; M. Drury; T. Powers

    2005-01-01

    All eighty-one fundamental power couplers for the 805 MHz superconducting cavities of the SNS linac have been RF conditioned and installed in the cryomodules successfully. The couplers were RF processed at JLAB or at the SNS in ORNL: more than forty couplers have been RF conditioned in the SNS RF Test Facility (RFTF) after the first forty couplers were conditioned at JLAB. The couplers were conditioned up to 650 kW forward power at 8% duty cycle in traveling and standing waves. They were installed on the cavities in the cryomodules and then assembled with the airside waveguide transitions. The couplers have been high power RF tested with satisfactory accelerating field gradients in the cooled cavities

  1. Multipacting studies in elliptic SRF cavities

    Science.gov (United States)

    Prakash, Ram; Jana, Arup Ratan; Kumar, Vinit

    2017-09-01

    performing any multi-particle simulation. This methodology has been employed along with computer code for the detailed analysis of multipacting in βg = 0 . 61 and βg = 0 . 9, 650 MHz elliptic SRF cavities that we have recently designed for the medium and high energy section of the proposed Indian Spallation Neutron Source (ISNS) project.

  2. Cavity-enhanced spectroscopies

    CERN Document Server

    van Zee, Roger

    2003-01-01

    ""Cavity-Enhanced Spectroscopy"" discusses the use of optical resonators and lasers to make sensitive spectroscopic measurements. This volume is written by the researcchers who pioneered these methods. The book reviews both the theory and practice behind these spectroscopic tools and discusses the scientific discoveries uncovered by these techniques. It begins with a chapter on the use of optical resonators for frequency stabilization of lasers, which is followed by in-depth chapters discussing cavity ring-down spectroscopy, frequency-modulated, cavity-enhanced spectroscopy, intracavity spectr

  3. Tuned optical cavity magnetometer

    Science.gov (United States)

    Okandan, Murat; Schwindt, Peter

    2010-11-02

    An atomic magnetometer is disclosed which utilizes an optical cavity formed from a grating and a mirror, with a vapor cell containing an alkali metal vapor located inside the optical cavity. Lasers are used to magnetically polarize the alkali metal vapor and to probe the vapor and generate a diffracted laser beam which can be used to sense a magnetic field. Electrostatic actuators can be used in the magnetometer for positioning of the mirror, or for modulation thereof. Another optical cavity can also be formed from the mirror and a second grating for sensing, adjusting, or stabilizing the position of the mirror.

  4. Hydroforming of elliptical cavities

    Science.gov (United States)

    Singer, W.; Singer, X.; Jelezov, I.; Kneisel, P.

    2015-02-01

    Activities of the past several years in developing the technique of forming seamless (weldless) cavity cells by hydroforming are summarized. An overview of the technique developed at DESY for the fabrication of single cells and multicells of the TESLA cavity shape is given and the major rf results are presented. The forming is performed by expanding a seamless tube with internal water pressure while simultaneously swaging it axially. Prior to the expansion the tube is necked at the iris area and at the ends. Tube radii and axial displacements are computer controlled during the forming process in accordance with results of finite element method simulations for necking and expansion using the experimentally obtained strain-stress relationship of tube material. In cooperation with industry different methods of niobium seamless tube production have been explored. The most appropriate and successful method is a combination of spinning or deep drawing with flow forming. Several single-cell niobium cavities of the 1.3 GHz TESLA shape were produced by hydroforming. They reached accelerating gradients Eacc up to 35 MV /m after buffered chemical polishing (BCP) and up to 42 MV /m after electropolishing (EP). More recent work concentrated on fabrication and testing of multicell and nine-cell cavities. Several seamless two- and three-cell units were explored. Accelerating gradients Eacc of 30 - 35 MV /m were measured after BCP and Eacc up to 40 MV /m were reached after EP. Nine-cell niobium cavities combining three three-cell units were completed at the company E. Zanon. These cavities reached accelerating gradients of Eacc=30 - 35 MV /m . One cavity is successfully integrated in an XFEL cryomodule and is used in the operation of the FLASH linear accelerator at DESY. Additionally the fabrication of bimetallic single-cell and multicell NbCu cavities by hydroforming was successfully developed. Several NbCu clad single-cell and double-cell cavities of the TESLA shape have been

  5. Hydroforming of elliptical cavities

    Directory of Open Access Journals (Sweden)

    W. Singer

    2015-02-01

    Full Text Available Activities of the past several years in developing the technique of forming seamless (weldless cavity cells by hydroforming are summarized. An overview of the technique developed at DESY for the fabrication of single cells and multicells of the TESLA cavity shape is given and the major rf results are presented. The forming is performed by expanding a seamless tube with internal water pressure while simultaneously swaging it axially. Prior to the expansion the tube is necked at the iris area and at the ends. Tube radii and axial displacements are computer controlled during the forming process in accordance with results of finite element method simulations for necking and expansion using the experimentally obtained strain-stress relationship of tube material. In cooperation with industry different methods of niobium seamless tube production have been explored. The most appropriate and successful method is a combination of spinning or deep drawing with flow forming. Several single-cell niobium cavities of the 1.3 GHz TESLA shape were produced by hydroforming. They reached accelerating gradients E_{acc} up to 35  MV/m after buffered chemical polishing (BCP and up to 42  MV/m after electropolishing (EP. More recent work concentrated on fabrication and testing of multicell and nine-cell cavities. Several seamless two- and three-cell units were explored. Accelerating gradients E_{acc} of 30–35  MV/m were measured after BCP and E_{acc} up to 40  MV/m were reached after EP. Nine-cell niobium cavities combining three three-cell units were completed at the company E. Zanon. These cavities reached accelerating gradients of E_{acc}=30–35  MV/m. One cavity is successfully integrated in an XFEL cryomodule and is used in the operation of the FLASH linear accelerator at DESY. Additionally the fabrication of bimetallic single-cell and multicell NbCu cavities by hydroforming was successfully developed. Several NbCu clad single-cell and

  6. The oral cavity is not a primary source for implantable pacemaker or cardioverter defibrillator infections

    Science.gov (United States)

    2013-01-01

    Background To test the hypothesis that the oral cavity is a potential source for implantable pacemaker and cardioverter defibrillators infections, the bacterial diversity on explanted rhythm heart management devices was investigated and compared to the oral microbiome. Methods A metagenomic approach was used to analyze the bacterial diversity on the surfaces of non-infected and infected pacemakers. The DNA from surfaces swaps of 24 non-infected and 23 infected pacemaker were isolated and subjected to bacterial-specific DNA amplification, single strand conformation polymorphism- (SSCP) and sequencing analysis. Species-specific primer sets were used to analyze for any correlation between bacterial diversity on pacemakers and in the oral cavity. Results DNA of bacterial origin was detected in 21 cases on infected pacemakers and assigned to the bacterial phylotypes Staphylococcus epidermidis, Propionibacterium acnes, Staphylococcus aureus, Staphylococcus schleiferi and Stapyhlococcus. In 17 cases bacterial DNA was found on pacemakers with no clinical signs of infections. On the basis of the obtained sequence data, the phylotypes Propionibacterium acnes, Staphylococcus and an uncultured bacterium were identified. Propionibacterium acnes and Staphylococcus epidermidis were the only bacteria detected in pacemeaker (n = 25) and oral samples (n = 11). Conclusions The frequency of the coincidental detection of bacteria on infected devices and in the oral cavity is low and the detected bacteria are highly abundant colonizers of non-oral human niches. The transmission of oral bacteria to the lead or device of implantable pacemaker or cardioverter defibrillators is unlikely relevant for the pathogenesis of pacemaker or cardioverter defibrillators infections. PMID:23575037

  7. Acne Vulgaris and Quality of Life Among Young Adults in South India

    Science.gov (United States)

    Durai, Priya Cinna T; Nair, Dhanya G

    2015-01-01

    Acne vulgaris is a chronic condition affecting more than 85% of adolescents and young adults. It is one of the most common diseases affecting humanity and its impact on quality of life (QoL) is important. The impact of acne on QoL in Indian patients remains undocumented. The study was undertaken to detect the impact of acne vulgaris and related factors that may influence the QoL. Materials and Methods: This was a hospital-based, prospective, cross-sectional, prestructured, questionnaire-based study done on 140 consenting individuals, who attended the Dermatology outpatient department. Acne vulgaris was graded using simple grading system. QoL was measured using a combination of skin disease-specific (Dermatological Life Quality Index (DLQI)) and acne-specific (Cardiff Acne Disability Index (CADI)) questionnaires. Results: Majority of our study population were students (103, 73.6%). Face (139, 99.3%) was the commonest site of acne and comedones 133, 95% were the commonest type of lesion. Most of the individuals 66, 47.1% were observed to have grade 1 acne. The mean DLQI score was 6.91 and the mean CADI score was 5.2. Association between the scores was statistically significant. Age, occupation, marital status, family, and treatment history played a role in affecting the QoL. Diet, smoking, and alcohol did not influence the QoL. Conclusion: Though acne had impact on patient's QoL, it was less severe in our study. It is important for health professionals to incorporate QoL measurements when managing acne patients to provide better and appropriate care. PMID:25657394

  8. Assessment of a new biological complex efficacy on dysseborrhea, inflammation, and Propionibacterium acnes proliferation

    Directory of Open Access Journals (Sweden)

    Trompezinski S

    2016-08-01

    Full Text Available Sandra Trompezinski,1 Sophie Weber,1 Benoît Cadars,2 Florence Larue,1 Nathalie Ardiet,1 Marlène Chavagnac-Bonneville,2 Michèle Sayag,2 Eric Jourdan2 1NAOS, Aix-en Provence, 2Direction Scientifique Bioderma (NAOS, Lyon, France Introduction: Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit triggered by Propionibacterium acnes. A bakuchiol, Ginkgo biloba extract, and mannitol (BGM complex has been developed to provide patients with acne with a specific dermocosmetic to be used adjunctively with conventional treatments. Objective: The aim of these studies was to assess the antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its individual compounds as well as its impact on sebum composition. Methods: The antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its compounds was assessed through in vitro, ex vivo, and clinical studies. The clinical benefit of BGM complex formulated in a cream was assessed in subjects prone to acne through sebum composition analysis and photometric assessments. Results: Results from the studies showed that the BGM complex has significant antibacterial, anti-inflammatory, and antioxidative properties. At similar concentrations, bakuchiol has up to twice the antioxidative potential than vitamin E. In subjects, BGM complex regulated the sebum composition in acne patients by increasing the level of sapienic and linolenic acid and reducing the level of oleic acid. The reduced number of porphyrins on the skin surface showed that it is also effective against P. acnes. Conclusion: BGM complex provides a complete adjunctive care in patients with acne by targeting etiopathogenic factors of acne: dysseborrhea, inflammation, and P. acnes proliferation. Keywords: acne, antibacterial, anti-inflammatory, antioxidation, cosmetics, sebum

  9. Effect of a single overnight topical application of miconazole nitrate paste on acne papules.

    Science.gov (United States)

    Flagothier, Caroline; Vroome, Valérie; Borgers, Marcel; Wang, Xuemin; Cauwenbergh, Geert; Piérard, Gérald E

    2006-03-01

    The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days. To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste. Narrow-band reflectance spectroscopy was used to assess the changes in E index (erythema) after overnight application of the pastes. In the first study, a total of 117 acne papules were assessed in 15 adolescents. Measurements of the E index were performed at 24-h intervals for 4 days on acne papules and the surrounding normal-looking skin. The last two assessments were performed the mornings preceding and following, respectively, a single application of the medicated paste. The second part of the study consisted of a double-blind, split-face study on 25 adolescents with acne. They applied each of the two formulations on a randomized part of the forehead. A total of 161 acne papules received the medicated paste and 160 received the same but unmedicated paste. Measurements were performed the mornings before and after the overnight treatment. In the first part of the study, no significant daily difference was observed between the three series of pretreatment E indices, on both acne papules and normal skin. The treatment did not affect the E index of normal skin. By contrast, it decreased significantly the E index of the acne papules. The second part of the study also showed that the medicated paste significantly decreased the E index of acne papules. This effect was significantly (P < 0.05) superior to that of the unmedicated paste. A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules.

  10. Construction and present status of KEKB superconducting cavities

    International Nuclear Information System (INIS)

    Tajima, T.; Akai, K.; Ezura, E; Furuya, T.; Hosoyama, K.; Mitsunobu, S.

    2000-01-01

    The superconducting cavity (SCC) for KEKB is 508 MHz single-cell cavity that has large beam pipes (22 cm and 30 cm i.d.) so that higher-order modes propagate out of the cavity and be absorbed by a lossy material. The input coupler is the TRISTAN-type coaxial one with some modifications such that dc bias voltage can be applied to avoid multipactoring during beam operation, fins to efficiently cool the outer conductor and a heater to remove condensed gases. The higher-order mode absorber is made of ferrite directly sinter-bonded on the inner surface of the copper pipe using a technique called Hot Isostatic Press (HIP). One prototype cavity was tested up to 0.57 A at TRISTAN Accumulation Ring (AR) in 1996. Then, four cavities were constructed for KEKB. One of the cavities achieved an accelerating field of 19 MV/m at a test in a vertical cryostat; this field is the world record at this frequency to our knowledge. No degradation of the field after assembly into horizontal cryostats was observed up to the available power of 300 kW that corresponds to ∼12 MV/m. These four cavities were installed in KEKB tunnel and are expected to supply 6 MV in total voltage to the 1.1 A electron beam in high energy ring (HER). Since beam commissioning started in Dec. 1998, the system has been supplying 6 MV and working very smoothly without any trouble. The maximum current has been 0.51 A and power delivered to beam per cavity is 370-380 kW/cavity up to the end of Apr., 1999. (author)

  11. Measurements of radio frequent cavity volt ages by X-ray spectrum measurements

    Directory of Open Access Journals (Sweden)

    Toprek Dragan

    2005-01-01

    Full Text Available This paper deals with X-ray spectrum measurement as a method for the measurement of radio frequent cavity voltage and the theory of X-ray spectrum calculation. Experimental results at 72 MHz for three different values of the radio frequent power of ACCEL K250 super conducting cyclotron are being presented.

  12. RF cavities of CESAR (2 MeV electron storage ring).

    CERN Multimedia

    Service Photo; CERN PhotoLab

    1968-01-01

    RF cavity. There were 2 identical ones: one for stacking (accumulation) procedures; the other for scanning with "empty buckets" (measurement of beam density distribution). Both were operated at h=2 (2nd harmonic of the revolution frequency), i.e. at around 24.4 MHz. Voltage, frequency and phase were programmed with analogue circuits.

  13. CESAR, 2 MeV electron storage ring; construction period; RF cavity.

    CERN Multimedia

    Service Photo; CERN PhotoLab

    1962-01-01

    RF cavity. There were 2 identical ones: one for stacking (accumulation) procedures; the other for scanning with "empty buckets" (measurement of beam density distribution). Both were operated at h=2 (2nd harmonic of the revolution frequency), i.e. at around 24.4 MHz. Voltage, frequency and phase were programmed with analogue circuits.

  14. Photoinactivation of Propionibacterium acnes by near-ultraviolet light

    International Nuclear Information System (INIS)

    Kjeldstad, B.

    1984-01-01

    Photodestruction of Propionibacterium acnes was investigated by broad-band near-ultraviolet light. The inactivation of the bacteria was found to be oxygen dependent, and without O 2 practically no photoinactivation occurred. D 2 O caused an increased inactivation (D 10 = 5 kJ/m 2 in D 2 O as compared to D 10 = 11 kJ/m 2 in normal water). Decreased temperature during illumination increased the ability to form colonies. The results are compared with corresponding results for other types of cells and the destruction mechanism is discussed. (orig.)

  15. Study of superconducting cavities for high power proton accelerators

    International Nuclear Information System (INIS)

    Biarrotte, J.L.

    2000-01-01

    The research program on hybrid reactors has started in France in order to study the technologies allowing the transmutation of radioactive wastes thanks to a spallation neutron source supplied by a linear high intensity proton accelerator. The study of the high energy part of this accelerator (superconducting accelerator for hybrid) has started, and its aim is the design of superconducting radiofrequency cavities which make the two different sections of the accelerator (0.47 and 0.65). This thesis presents the advance of the work carried out on this topic since 1997, in particular the design and optimization of the 5-cell cavities which work at the 704.4 MHz frequency. The experimental part of the study has been carried out in parallel with the industrial fabrication (Cerca) of several prototypes of mono-cell cavities. These cavities have shown very good RF performances during the tests in vertical cryostat; the A 102 A cavity, in particular develops a Q0 of 7.10 10 (indicating very low RF losses) and reaches an accelerator field of 25 MV/m, i.e. more than two times the specified value (about 10 MV/V). Finally, a new risk analysis method for the excitation of the upper modes is proposed. This method shows in particular the uselessness of the implementation of HOM couplers on the cavities for a continuous beam use. (J.S.)

  16. Current treatments of acne: Medications, lights, lasers, and a novel 650-μs 1064-nm Nd: YAG laser.

    Science.gov (United States)

    Gold, Michael H; Goldberg, David J; Nestor, Mark S

    2017-09-01

    The treatment of acne, especially severe acne, remains a challenge to dermatologists. Therapies include retinoids, antibiotics, hormones, lights, lasers, and various combinations of these modalities. Acne is currently considered a chronic rather than an adolescent condition. The appropriate treatment depends on the patient and the severity of disease. The purpose of this study was to review current therapies for acne of all severities and to introduce the 650-μs 1064-nm laser for the treatment of acne. © 2017 Wiley Periodicals, Inc.

  17. Dental Sealants Prevent Cavities

    Science.gov (United States)

    ... Digital Press Kit Read the MMWR Science Clips Dental Sealants Prevent Cavities Effective protection for children Language: ... more use of sealants and reimbursement of services. Dental care providers can Apply sealants to children at ...

  18. Statistical electromagnetics: Complex cavities

    NARCIS (Netherlands)

    Naus, H.W.L.

    2008-01-01

    A selection of the literature on the statistical description of electromagnetic fields and complex cavities is concisely reviewed. Some essential concepts, for example, the application of the central limit theorem and the maximum entropy principle, are scrutinized. Implicit assumptions, biased

  19. accelerating cavity from LEP

    CERN Multimedia

    This is an accelerating cavity from LEP, with a layer of niobium on the inside. Operating at 4.2 degrees above absolute zero, the niobium is superconducting and carries an accelerating field of 6 million volts per metre with negligible losses. Each cavity has a surface of 6 m2. The niobium layer is only 1.2 microns thick, ten times thinner than a hair. Such a large area had never been coated to such a high accuracy. A speck of dust could ruin the performance of the whole cavity so the work had to be done in an extremely clean environment. These challenging requirements pushed European industry to new achievements. 256 of these cavities are now used in LEP to double the energy of the particle beams.

  20. Absceso cerebral posquirúrgico causado por Propionibacterium acnes Post-surgery cerebral abscess due to Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Mariela S. Zárate

    2009-02-01

    Full Text Available Los abscesos cerebrales por Propionibacterium acnes son poco frecuentes. Es importante para el médico clínico la rápida identificación de este patógeno para la elección de una terapéutica antibiótica adecuada. En este caso se describe un paciente con una exéresis de un glioblastoma multiforme donde a los 9 meses se evidenció la existencia de una recidiva tumoral, se efectuó una extirpación tumoral subtotal y la colocación de implantes de quimioterapia en el lecho tumoral residual. Al cabo de un mes de esta reoperación presentó una lesión ocupante compatible con un absceso cerebral, motivo por el cual se realizó nueva craneotomía y drenaje del mismo. En los cultivos de las biopsias y del material purulento se aisló P. acnes como flora única. Para la identificación se realizaron pruebas bioquímicas y se aplicó el sistema API20A. Se determinó la concentración inhibitoria mínima (CIM a clindamicina, penicilina, amoxicilina y metronidazol, los valores de CIM (ug/ml obtenidos fueron: 0.250, 0.040, 0.023 y 256, respectivamente. El paciente recibió cefepime más metronidazol por vía endovenosa durante un período de 30 días y completó tratamiento con clindamicina por vía oral durante 60 días, dada la posible complicación ósea en el sitio de la infección. Luego de 8 meses de la intervención quirúrgica y el drenaje del absceso cerebral no hubo evidencia de signos clínicos de recidiva tumoral e infecciosa. P. acnes es un patógeno infrecuente como causal de abscesos cerebrales, sin embargo no se debe desestimar en muestras neuroquirúrgicas.Brain abscesses by Propionibacterium acnes are rare. The rapid identification of this pathogen is important in order to choice the appropriate antibiotic therapy. We describe the case of a patient with excision of a multiform glioblastoma who 9 months later presented a tumor recurrence. A subtotal tumor excision was made and implants chemotherapy were placed in the residual tumor

  1. Hybrid vertical cavity laser

    DEFF Research Database (Denmark)

    Chung, Il-Sug; Mørk, Jesper

    2010-01-01

    A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide.......A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide....

  2. Development of niobium spoke cavities for a superconducting light-ion linac

    International Nuclear Information System (INIS)

    Shepard, K.W.; Kedzie, M.; Delayen, J.R.; Piller, C.

    1998-01-01

    This paper reports the development of 350 MHz niobium superconducting cavities for the velocity range 0.2 < v/c < 0.6. Such cavities could be used to form a linac of exceptional flexibility, capable of efficiently accelerating beams of either protons, deuterons, or any of a wide range of ions, at intensities sufficient for a production beam for a radioactive facility. Results of numerical modeling for several resonator geometries are presented. The design and construction status of prototype niobium cavities is discussed

  3. Development of niobium spoke cavities for a superconducting light-ion Linac

    International Nuclear Information System (INIS)

    Shepard, K. W.

    1998-01-01

    This paper reports the development of 350 MHz niobium superconducting cavities for the velocity range 0.2< v/c <0.6. Such cavities could be used to form a linac of exceptional flexibility, capable of efficiently accelerating beams of either protons, deuterons, or any of a wide range of light ions, at intensities sufficient for a production beam for a radioactive beam facility. Results of numerical modeling for several resonator geometries are presented. The design and construction status of prototype niobium cavities is discussed

  4. Mode-locked Pr3+-doped silica fiber laser with an external cavity

    DEFF Research Database (Denmark)

    Shi, Yuan; Poulsen, Christian; Sejka, Milan

    1994-01-01

    We present a Pr3+-doped silica-based fiber laser mode-locked by using a linear external cavity with a vibrating mirror. Stable laser pulses with a FWHM of less than 44 ps, peak power greater than 9 W, and repetition rate up to 100 MHz are obtained. The pulse width versus cavity mismatch ΔL and pump...... power have been investigated. With a short piece of nonlinear fiber included in the external cavity, laser pulses of 45 ps have been measured...

  5. Conceptual design of the RF accelerating cavities for a superconducting cyclotron

    International Nuclear Information System (INIS)

    Maggiore, M.; Calabretta, L.; Di Giacomo, M.; Rifuggiato, D.; Battaglia, D.; Piazza, L.

    2006-01-01

    A superconducting cyclotron accelerating ions up to 250 A MeV, for medical applications and radioactive ions production is being studied at Laboratori Nazionali del Sud in Catania. The radio frequency (RF) system, working in the fourth harmonic, is based on four normal conducting radio frequency cavities operating at 93 MHz. This paper describes an unusual multi-stem cavity design, performed with 3D electromagnetic codes. Our aim is to obtain a cavity, completely housed inside the cyclotron, with a voltage distribution ranging from 65 kV in the injection region to a peak value of 120 kV in the extraction region, and having a low power consumption

  6. Effects of Crab Cavities' Multipole Content in an Electron-Ion Collider

    International Nuclear Information System (INIS)

    Satogata, Todd J.; Morozov, Vasiliy; Delayen, Jean R.; Castillo, Alejandro

    2015-09-01

    The impact on the beam dynamics of the Medium Energy Electron-Ion Colider (MEIC) due to the multipole content of the 750 MHz crab cavity was studied using thin multipole elements for 6D phase space particle tracking in ELEGANT. Target values of the sextupole component for the cavity's field expansion were used to perform preliminary studies on the proton beam stability when compared to the case of pure dipole content of the rf kicks. Finally, important effects on the beam sizes due to non-linear components of the crab cavities' fields were identified, and some criteria for their future study were proposed.

  7. High-power RF cavity R ampersand D for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Rimmer, R.; Lambertson, G.; Hodgson, J.

    1994-06-01

    We describe the development of a high-power test model of the 476 MHz RF cavity for the PEP-II B Factory. This cavity is designed to demonstrate the feasibility of a high-power design with higher-order mode (HOM) damping waveguides and the fabrication technologies involved, and it can also be used to evaluate aperture or loop couplers and various RF windows. Changes to the RF design to reduce peak surface heating are discussed and results of finite-element analyses of temperature and stress are presented. Fabrication methods for the prototype and subsequent production cavities are discussed

  8. Reducing field emission in the superconducting rf cavities for the next generation of particle accelerators

    International Nuclear Information System (INIS)

    Shu, Q.S.; Hartung, W.; Leibovich, A.; Kirchgessner, J.; Moffat, D.; Padamsee, H.; Rubin, D.; Sears, J.

    1991-01-01

    This paper reports on field emission, which is an obstacle to reaching the higher fields called for in future applications of superconducting radio frequency cavities to particle accelerators. The authors used heat treatment up to 1500 degrees C in an ultra-high vacuum furnace, along with processing of cavities and temperature mapping, to suppress field emission and analyze emitter properties. In 27 tests of 1-cell 1500 MHz fired accelerating cavities, on the average the accelerating field E acc increased to 24 MV/m (H pk = 1250 Oe) from 13 MV/m with chemical treatment alone; the highest E acc reached was 30.5 MV/m

  9. Development of niobium spoke cavities for a superconducting light-ion linac

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, K W; Kedzie, M; Delayen, J R; Piller, C

    1998-08-01

    This paper reports the development of 350 MHz niobium superconducting cavities for the velocity range 0.2 < v/c < 0.6. Such cavities could be used to form a linac of exceptional flexibility, capable of efficiently accelerating beams of either protons, deuterons, or any of a wide range of ions, at intensities sufficient for a production beam for a radioactive facility. Results of numerical modeling for several resonator geometries are presented. The design and construction status of prototype niobium cavities is discussed.

  10. Development of niobium spoke cavities for a superconducting light-ion Linac.

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, K. W.

    1998-11-18

    This paper reports the development of 350 MHz niobium superconducting cavities for the velocity range 0.2< v/c <0.6. Such cavities could be used to form a linac of exceptional flexibility, capable of efficiently accelerating beams of either protons, deuterons, or any of a wide range of light ions, at intensities sufficient for a production beam for a radioactive beam facility. Results of numerical modeling for several resonator geometries are presented. The design and construction status of prototype niobium cavities is discussed.

  11. Dependence of the surface resistance of niobium coated copper cavities on the coating temperature

    International Nuclear Information System (INIS)

    Darriulat, P.; Durand, C.; Janot, P.; Rensing, N.; Weingarten, W.; Bosland, P.; Gobin, J.; Martignac, J.

    1996-01-01

    Six hydro-formed copper 1.5 GHz cavities have been baked and coated with niobium at different temperatures between 100 deg C and 200 deg C, while keeping the other discharge parameters unchanged. Their surface resistance has been measured as a function RF field and trapped magnetic field. Its dependence on deposition temperature confirms earlier indications obtained using 350 MHz LEP cavities that 150 deg C leads to optimal performances. The critical temperatures of Nb/Cu and bulk niobium cavities have also been measured. (author)

  12. The Superconducting TESLA Cavities

    CERN Document Server

    Aune, B.; Bloess, D.; Bonin, B.; Bosotti, A.; Champion, M.; Crawford, C.; Deppe, G.; Dwersteg, B.; Edwards, D.A.; Edwards, H.T.; Ferrario, M.; Fouaidy, M.; Gall, P-D.; Gamp, A.; Gössel, A.; Graber, J.; Hubert, D.; Hüning, M.; Juillard, M.; Junquera, T.; Kaiser, H.; Kreps, G.; Kuchnir, M.; Lange, R.; Leenen, M.; Liepe, M.; Lilje, L.; Matheisen, A.; Möller, W-D.; Mosnier, A.; Padamsee, H.; Pagani, C.; Pekeler, M.; Peters, H-B.; Peters, O.; Proch, D.; Rehlich, K.; Reschke, D.; Safa, H.; Schilcher, T.; Schmüser, P.; Sekutowicz, J.; Simrock, S.; Singer, W.; Tigner, M.; Trines, D.; Twarowski, K.; Weichert, G.; Weisend, J.; Wojtkiewicz, J.; Wolff, S.; Zapfe, K.

    2000-01-01

    The conceptional design of the proposed linear electron-positron colliderTESLA is based on 9-cell 1.3 GHz superconducting niobium cavities with anaccelerating gradient of Eacc >= 25 MV/m at a quality factor Q0 > 5E+9. Thedesign goal for the cavities of the TESLA Test Facility (TTF) linac was set tothe more moderate value of Eacc >= 15 MV/m. In a first series of 27industrially produced TTF cavities the average gradient at Q0 = 5E+9 wasmeasured to be 20.1 +- 6.2 MV/m, excluding a few cavities suffering fromserious fabrication or material defects. In the second production of 24 TTFcavities additional quality control measures were introduced, in particular aneddy-current scan to eliminate niobium sheets with foreign material inclusionsand stringent prescriptions for carrying out the electron-beam welds. Theaverage gradient of these cavities at Q0 = 5E+9 amounts to 25.0 +- 3.2 MV/mwith the exception of one cavity suffering from a weld defect. Hence only amoderate improvement in production and preparation technique...

  13. Use of a Cutaneous Body Image (CBI) scale to evaluate self perception of body image in acne vulgaris.

    Science.gov (United States)

    Amr, Mostafa; Kaliyadan, Feroze; Shams, Tarek

    2014-01-01

    Skin disorders such as acne, which have significant cosmetic implications, can affect the self-perception of cutaneous body image. There are many scales which measure self-perception of cutaneous body image. We evaluated the use of a simple Cutaneous Body Image (CBI) scale to assess self-perception of body image in a sample of young Arab patients affected with acne. A total of 70 patients with acne answered the CBI questionnaire. The CBI score was correlated with the severity of acne and acne scarring, gender, and history of retinoids use. There was no statistically significant correlation between CBI and the other parameters - gender, acne/acne scarring severity, and use of retinoids. Our study suggests that cutaneous body image perception in Arab patients with acne was not dependent on variables like gender and severity of acne or acne scarring. A simple CBI scale alone is not a sufficiently reliable tool to assess self-perception of body image in patients with acne vulgaris.

  14. Cavity optomechanics in gallium phosphide microdisks

    International Nuclear Information System (INIS)

    Mitchell, Matthew; Barclay, Paul E.; Hryciw, Aaron C.

    2014-01-01

    We demonstrate gallium phosphide (GaP) microdisk optical cavities with intrinsic quality factors >2.8 × 10 5 and mode volumes 3 , and study their nonlinear and optomechanical properties. For optical intensities up to 8.0 × 10 4 intracavity photons, we observe optical loss in the microcavity to decrease with increasing intensity, indicating that saturable absorption sites are present in the GaP material, and that two-photon absorption is not significant. We observe optomechanical coupling between optical modes of the microdisk around 1.5 μm and several mechanical resonances, and measure an optical spring effect consistent with a theoretically predicted optomechanical coupling rate g 0 /2π∼30 kHz for the fundamental mechanical radial breathing mode at 488 MHz

  15. Design of radio-frequency cavities and Tera-Hertz electron injectors for advanced applications

    Energy Technology Data Exchange (ETDEWEB)

    Seyedfakhari, Seyedmoein

    2016-06-15

    Design of three accelerator components including a buncher cavity for REGAE, a normal conducting cavity for arrival time stabilization at FLASH and ultra-fast guns for the AXSIS project is presented in this thesis. Using RF cavities caused a revolution in accelerators and made it possible to generate high energy particle beams. In advanced accelerators, cavities are not only used to increase the particle energy but they are also widely used to improve the beam quality and additionally for beam diagnostic purposes. In the present dissertation, such applications are discussed. First, design of a buncher cavity which compresses the bunch at the REGAE facility is presented. The design pursues improving the mode separation of the cavity. The simulation result illustrates that the difference between the operating mode and its adjacent mode has been increased from 2 MHz for the existing cavity to 9.5 MHz for the new design. In the second part, a normal conducting cavity is discussed, which will be used to regulate the arrival time ofthe bunches at FLASH and at the European XFEL. The designed cavity is able to correct the arrival time jitter of ± 150 fs in order to provide femtosecond precision synchronization between the electron beam and the external laser pulses. Thermal, wakefield and multipacting simulations have also been performed for the designed cavity in order to evaluate its operation efficiency. In advanced accelerators however RF cavities should be replaced by novel structures to accelerate the particles in shorter distances using higher operating frequency. To this end, ultra-fast guns are designed which will be discussed in the last part of this work. The designed guns accelerate the electrons from their rest mass up to 2 MeV using a single cycle THz signal with a total energy of 2 mJ.

  16. Design of radio-frequency cavities and Tera-Hertz electron injectors for advanced applications

    International Nuclear Information System (INIS)

    Seyedfakhari, Seyedmoein

    2016-06-01

    Design of three accelerator components including a buncher cavity for REGAE, a normal conducting cavity for arrival time stabilization at FLASH and ultra-fast guns for the AXSIS project is presented in this thesis. Using RF cavities caused a revolution in accelerators and made it possible to generate high energy particle beams. In advanced accelerators, cavities are not only used to increase the particle energy but they are also widely used to improve the beam quality and additionally for beam diagnostic purposes. In the present dissertation, such applications are discussed. First, design of a buncher cavity which compresses the bunch at the REGAE facility is presented. The design pursues improving the mode separation of the cavity. The simulation result illustrates that the difference between the operating mode and its adjacent mode has been increased from 2 MHz for the existing cavity to 9.5 MHz for the new design. In the second part, a normal conducting cavity is discussed, which will be used to regulate the arrival time ofthe bunches at FLASH and at the European XFEL. The designed cavity is able to correct the arrival time jitter of ± 150 fs in order to provide femtosecond precision synchronization between the electron beam and the external laser pulses. Thermal, wakefield and multipacting simulations have also been performed for the designed cavity in order to evaluate its operation efficiency. In advanced accelerators however RF cavities should be replaced by novel structures to accelerate the particles in shorter distances using higher operating frequency. To this end, ultra-fast guns are designed which will be discussed in the last part of this work. The designed guns accelerate the electrons from their rest mass up to 2 MeV using a single cycle THz signal with a total energy of 2 mJ.

  17. Superconducting Prototype Cavities for the Spallation Neutron Source (SNS) Project

    International Nuclear Information System (INIS)

    Ciovati, G.; Kneisel, P.; Brawley, J.; Bundy, R.; Campisi, I.; Davis, K.; Macha, K.; Machie, D.; Mammosser, J.; Morgan, S.; Sundelin, R.; Turlington, L.; Wilson, K.; Doleans, M.; Kim, S.H.; Barni, D.; Pagani, C.; Pierini, P.; Matsumoto, K.; Mitchell, R.; Schrage, D.; Parodi, R.; Sekutowicz, J.; Ylae-Oijala, P.

    2001-01-01

    The Spallation Neutron Source project includes a superconducting linac section in the energy range from 192 MeV to 1000 MeV, operating at a frequency of 805 MHz at 2.1 K. For this energy range two types of cavities are needed with geometrical beta - values of beta= 0.61 and beta= 0.81. An aggressive cavity prototyping program is being pursued at Jlab, which calls for fabricating and testing of four beta= 0.61 cavities and two beta= 0.81 cavities. Both types consist of six cells made from high purity niobium and feature one HOM coupler on each beam pipe and a port for a high power coaxial input coupler. Three of the four beta= 0.61 cavities will be used for a cryomodule test in early 2002. At this time four medium beta cavities and one high beta cavity have been completed at JLab. The first tests on the beta=0.61 cavity and the beta= 0.81 exceeded the design values for gradient and Q - value: E acc = 1 0.3 MV/m and Q = 5 x 10 9 at 2.1K for beta= 0.61 and E acc = 12.3 MV/m and Q = 5 x 10 9 at 2.1K for beta= 0.81. One of the medium beta cavities has been equipped with an integrated helium vessel and measurements of the static and dynamic Lorentz force detuning will be done and compared to the ''bare'' cavities. In addition two single cell cavities have been fabricated, equipped with welded-on HOM couplers. They are being used to evaluate the HOM couplers with respect to multipacting, fundamental mode rejection and HOM damping as far as possible in a single cell. This paper will describe the cavity design with respect to electrical and mechanical features, the fabrication efforts and the results obtained with the different cavities existing at the time of this workshop

  18. Chronic Subdural Hematoma Infected by Propionibacterium Acnes: A Case Report

    Science.gov (United States)

    Yamamoto, Shusuke; Asahi, Takashi; Akioka, Naoki; Kashiwazaki, Daina; Kuwayama, Naoya; Kuroda, Satoshi

    2015-01-01

    We present a very rare case of a patient with an infected subdural hematoma due to Propionibacterium acnes. A 63-year-old male complained of dizziness and was admitted to our hospital. He had a history of left chronic subdural hematoma due to a traffic accident, which had been conservatively treated. Physical, neurological and laboratory examinations revealed no definite abnormality. Plain CT scan demonstrated a hypodense crescentic fluid collection over the surface of the left cerebral hemisphere. The patient was diagnosed with chronic subdural hematoma and underwent burr hole surgery three times and selective embolization of the middle meningeal artery, but the lesion easily recurred. Repeated culture examinations of white sedimentation detected P. acnes. Therefore, he underwent craniotomy surgery followed by intravenous administration of antibiotics. The infected subdural hematoma was covered with a thick, yellowish outer membrane, and the large volume of pus and hematoma was removed. However, the lesion recurred again and a low-density area developed in the left frontal lobe. Craniotomy surgery was performed a second time, and two Penrose drainages were put in both the epidural and subdural spaces. Subsequently, the lesions completely resolved and he was discharged without any neurological deficits. Infected subdural hematoma may be refractory to burr hole surgery or craniotomy alone, in which case aggressive treatment with craniotomy and continuous drainage should be indicated before the brain parenchyma suffers irreversible damage. PMID:25759659

  19. Effects of motherwort alkaloids on rat ear acne

    Directory of Open Access Journals (Sweden)

    Miao Mingsan

    2016-04-01

    Full Text Available The aim of this study was to explore the effects of motherwort alkaloids on rat ear acne. The rats that were administered high, medium, and low doses of motherwort alkaloids, tanshinone capsules, a model and a control group. Each group of rats was subjected to gavage once daily for 14 consecutive days. On the first day of testing, the control and model groups were administered an intradermal auricle injection of sterilized saline solution and the remaining groups were administered an intradermal auricle injection of Staphylococcus epidermidis in addition to the gavage. The thicknesses of the rats’ auricles were measured for five consecutive days following the injections. Anticoagulated blood was used for erythrocyte rheology index measurement. In addition, the entire ear of each rat was removed for morphological examination. Compared to the model group, the group administered motherwort alkaloids exhibited significantly reduced swelling, improved localized auricle proliferation, and reduced blood viscosity. This result suggests motherwort alkaloids are effective in rat ear acne.

  20. Association between Propionibacterium acnes and frozen shoulder: a pilot study.

    Science.gov (United States)

    Bunker, Tim D; Boyd, Matthew; Gallacher, Sian; Auckland, Cressida R; Kitson, Jeff; Smith, Chris D

    2014-10-01

    Frozen shoulder has not previously been shown to be associated with infection. The present study set out to confirm the null hypothesis that there is no relationship between infection and frozen shoulder using two modern scientific methods, extended culture and polymerase chain reaction (PCR) for bacterial nucleic acids. A prospective cohort of 10 patients undergoing arthroscopic release for stage II idiopathic frozen shoulder had two biopsies of tissue taken from the affected shoulder joint capsule at the time of surgery, along with control biopsies of subdermal fat. The biopsies and controls were examined with extended culture and PCR for microbial nucleic acid. Eight of the 10 patients had positive findings on extended culture in their shoulder capsule and, in six of these, Propionibacterium acnes was present. The findings mean that we must reject the null hypothesis that there is no relationship between infection and frozen shoulder. More studies are urgently needed to confirm or refute these findings. If they are confirmed, this could potentially lead to new and effective treatments for this common, painful and disabling condition. Could P. acnes be the Helicobacter of frozen shoulder?

  1. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

    OpenAIRE

    Ismail, Noor Hasnani; Manaf, Zahara Abdul; Azizan, Noor Zalmy

    2012-01-01

    Abstract Background The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults. Methods A case–control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS) was used to determine acne severity. A questionnaire comprising...

  2. The effect of personal, familial, and environmental characteristics on acne vulgaris: a prospective, multicenter, case controlled study from Turkey.

    Science.gov (United States)

    Karadağ, Ayşe S; Balta, İlknur; Saricaoğlu, Hayriye; Kiliç, Selim; Kelekçi, Kıymet H; Yildirim, Mehmet; Arica, Deniz A; Öztürk, Savaş; Karaman, Göksun; Çerman, Aslı A; Bilgili, Serap G; Turan, Enver; Demirci, Mustafa M; Uzunçakmak, Tuğba K; Güvenç, Serdar C; Ataseven, Arzu; Ferahbaş, Ayten; Aksoy, Berna; Çölgeçen, Emine; Ekiz, Özlem; Topaloğlu Demir, Filiz; Bilgiç, Özlem; Çakmak, Seray; Uçmak, Derya; Özuğuz, Pınar; Kaymak Konkuralp, Yeşim; Ermertcan, Aylin T; Gökdemir, Gonca; Bülbül Başkan, Emel; Alyamaç, Gökçen; Şanli, Hatice

    2017-07-11

    There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. A total of 3826 patients and 759 control patients were involved in this study. Mild acne was the most common type of acne, and most of the lesions were localized on face followed by the trunk. The severity of acne was worse in patients who had a positive family history of acne. The most common triggering factor was psychological stress. We found a positive correlation with chocolate, bread, green tea, milk, white sugar, ripe banana, ice cream, apple, orange, and red meat consumption. As we compare the acne severity according to geographical features we detected mildmoderate acne was more common in Mediterrenean region and severe acne was more common in East Anatolian region. Family history positivity was more common in Aegean region and least common in Middle Anatolian region. There was statistically significant relationship as we compare acne severity and dietary factors such as chocolate, dairy products such as milk, sunflower seed consumption within the geographical regions. This study presents the demographic and clinical characteristics of acne patients in Asian and the European parts of Turkey. We believe that this study will provide a useful overview of acne in Turkey.

  3. 0.5% Liposome-encapsulated 5-aminolevulinic acid (ALA) photodynamic therapy for acne treatment.

    Science.gov (United States)

    An, Jee-Soo; Kim, Jeong-Eun; Lee, Dong-Hun; Kim, Byung-Yoon; Cho, Soyun; Kwon, In-Ho; Choi, Won-Woo; Kang, Seong-Min; Won, Chong-Hyun; Chang, Sung-Eun; Lee, Mi-Woo; Choi, Jee-Ho; Moon, Kee-Chan

    2011-02-01

    Photodynamic therapy using topical 5-aminolevulinic acid (ALA) has been successful in treating acne vulgaris, but sun avoidance for at least 48 hours after treatment is necessary due to the risk of post-treatment photosensitivity. Recently, a lower concentration of liposome-encapsulated 5-ALA was introduced to minimize this risk. To evaluate the efficacy and safety of liposome-encapsulated 0.5% 5-ALA in the photodynamic therapy of inflammatory acne and its effects on sebum secretion in Asian skin. Thirteen Korean subjects with inflammatory acne were administered 0.5% ALA spray before photoradiation treatment. Photoradiation was performed at 3.5-6.0 J/cm(2) three times during each of two visits, performed 2 weeks apart. Improvement of acne was evaluated subjectively and objectively based on the Korean Acne Grading System. Sebum secretion was measured quantitatively at each visit. The mean reduction in acne grade at the end of the treatment was 43.2%. Of the patients, 69.2% reported improvements in subjective skin oiliness, but fewer showed objective reductions in sebum secretion as determined by the Sebumeter® SM10. No serious adverse events were observed. Photodynamic therapy using liposome-encapsulated 0.5% 5-ALA improved inflammatory acne with minimal side effects in Asians.

  4. [Bacterial resistance in acne? A meta-analysis of the controversy].

    Science.gov (United States)

    Alvarez-Sánchez, Mariana; Rodríguez-Ayala, Ernesto; Ponce-Olivera, Rosa María; Tirado-Sánchez, Andrés; Arellano-Mendoza, María Ivonne

    2016-01-01

    Acne is one of the dermatological pathologies with the highest incidence around the world. It is a multifactorial disease and its treatment can be complex. Propionibacterium acnes play a key role in the inflammation of this dermatosis. Topical antibiotics, including mainly erythromycin and clindamycin, have been used, but there is controversy over their use due to the widely documented bacterial resistance. For this reason a meta-analysis of the publications over the past 10 years is presented in order to confirm this hypothesis. A search was made of the publications over the past 10 years that included the results of antibiogams of patients with acne. MeSH type searches were performed with the terms "acne vulgaris", "Propionibacterium acnes", "topical administration", "treatment", "erythromycin", "clindamycin", "nadifloxacin", "antibacterial agent", "bacterial drug resistance" in PubMed, Ovid, EBSCO, Cochrane, ScienceDirect and ClinicalKey meta-searches. A total of 13 articles were found that met the inclusion criteria. The mean odds ratio (OR 1.24, 95% CI) of the articles showed a slight tendency toward resistance of Propionibacterium acnes. An increase in bacterial resistance to topical erythromycin and clindamycin can be confirmed, thus the use of these antibiotics is recommended in selective cases for short periods, and in combination with benzoyl peroxide for the best clinical outcome in patients with acne vulgaris. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  5. Cosmeceuticals based on Rhealba(®) Oat plantlet extract for the treatment of acne vulgaris.

    Science.gov (United States)

    Fabbrocini, G; Saint Aroman, M

    2014-12-01

    Recent evidence suggests that acne vulgaris begins as an inflammation in and around the sebaceous gland and alterations in the lipid content of sebum, which drive hyperproliferation and increased desquamation of keratinocytes within sebaceous follicles. This prevents sebum drainage, causing the formation of microcomedones, which spontaneously regress or become acne lesions when the pilosebaceous unit is further blocked by the accumulation of corneocytes. These conditions are favourable for the proliferation of Propionibacterium acnes, which further aggravates acne by enhancing abnormal desquamation, sebum production and inflammation. Also, skin fragility due to inflammation or irritation by anti-comedogenic agents can worsen the situation. Rhealba(®) Oat plantlet extract (Pierre Fabre Dermo Cosmetique) soothes and restores fragile skin in acne by reducing inflammation and inhibits bacterial adhesion of Propionibacterium acnes. Cosmeceuticals combining Rhealba(®) Oat plantlet extract and hydro-compensating actives, which are available with or without anti-comedogenic hydroxy acids, provide a balanced, multifaceted approach for acne patients. © 2014 European Academy of Dermatology and Venereology.

  6. Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.

    Science.gov (United States)

    Nasri, Hamid; Bahmani, Mahmoud; Shahinfard, Najmeh; Moradi Nafchi, Atefeh; Saberianpour, Shirin; Rafieian Kopaei, Mahmoud

    2015-11-01

    Acne vulgaris affects about 85% of teenagers and may continue to adulthood. There are about two million visits to physicians per year for teenagers and the direct cost of acne treatment in the US exceeds $1 billion per year. A wide variety of treatment regimens exist for acne vulgaris including benzoil peroxide, retinoids, isotretinoids, keratolytic soaps, alpha hydroxy acids, azelaic acid, salicilic acid as well as hormonal, anti-androgen or antiseborrheic treatments. However, none of these methods is free of side effects and their exact role in therapy is not clear. In this paper apart from presenting the possible causes of acne vulgaris and its available drugs, recently published papers about medicinal plants used in the treatment of acne vulgaris were reviewed. Consumption of alternative and complementary medicine, including medicinal plants, is increasing and is common amongst patients affected by acne and infectious skin diseases. Medicinal plants have a long history of use and have been shown to possess low side effects. These plants are a reliable source for preparation of new drugs. Many plants seem to have inhibitory effects on the growth of bacteria, fungi and viruses in vitro. However, there are a few clinical evidences about the effectiveness and safety of these plants in the treatment of acne and other skin infections.

  7. Use of radiofrequency in cosmetic dermatology: focus on nonablative treatment of acne scars

    Directory of Open Access Journals (Sweden)

    Simmons BJ

    2014-12-01

    Full Text Available Brian J Simmons, Robert D Griffith, Leyre A Falto-Aizpurua, Keyvan Nouri Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, University of Miami, Miami, FL, USA Abstract: Acne is a common affliction among many teens and some adults that usually resolves over time. However, the severe sequela of acne scarring can lead to long-term psychological and psychiatric problems. There exists a multitude of modalities to treat acne scars such as more invasive surgical techniques, subcision, chemical peels, ablative lasers, fractional lasers, etc. A more recent technique for the treatment of acne scars is nonablative radiofrequency (RF that works by passing a current through the dermis at a preset depth to produce small thermal wounds in the dermis which, in turn, stimulates dermal remodeling to produce new collagen and soften scar defects. This review article demonstrates that out of all RF modalities, microneedle bipolar RF and fractional bipolar RF treatments offers the best results for acne scarring. An improvement of 25%–75% can be expected after three to four treatment sessions using one to two passes per session. Treatment results are optimal approximately 3 months after final treatment. Common side effects can include transient pain, erythema, and scabbing. Further studies are needed to determine what RF treatment modalities work best for specific scar subtypes, so that further optimization of RF treatments for acne scars can be determined. Keywords: acne scarring, radiofrequency treatments, nonablative radiofrequency treatments, scars

  8. Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.

    Science.gov (United States)

    Al-Talib, Hassanain; Al-Khateeb, Alyaa; Hameed, Ayad; Murugaiah, Chandrika

    2017-01-01

    Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid.

  9. 300-MHz optical discriminator-counter

    International Nuclear Information System (INIS)

    Turko, B.; Lo, C.C.

    1981-07-01

    The prediction of future CO 2 content in the atmosphere is not completely credible because the oceanographers and terrestrial ecologists do not agree on the global CO 2 balance. Very precise measurements of O 2 /N 2 ratio using Raman scattering over a few years' period could provide important information and lead to the explanation of the disparity in the atmospheric CO 2 balance. An optical discriminator-counter has been developed to count closely spaced optical events in the few photon level. Simulated optical events as close as 2.5 ns apart had been positively detected by using selected photomultipliers and optimized discriminators. Testing of the optical discriminator-counter was done by using an electrical pulse pair spaced 3 ns apart and also by a similar optical pulse pair generated by fast light-emitting diode. The photomultiplier is capable of counting an average single photoelectron pulse frequency of 50 MHz and has a sensitive detecting area of 50 mm in diameter. The discriminator performance is discussed

  10. 500 MHz transient digitizers based on GaAs CCDs

    International Nuclear Information System (INIS)

    Bryman, D.A.; Constable, M.; Cresswell, J.V.; Daviel, A.; LeNoble, M.; Mildenberger, J.; Poutissou, R.

    1996-11-01

    A system of 500 MHz transient digitizers based on gallium arsenide resistive gate charged coupled devices has been developed for an experiment studying rare K decays. CCDs with dynamic range of 8-bits and 128 or 320 pixels are used as analog pipelines. The CCD's are driven by a single phase transport system. Data readout and manipulation occurs at 15.6 MHz. (authors)

  11. The 200 MHz accelerating structure for UNK

    International Nuclear Information System (INIS)

    Katalev, V.V.; Kovalev, S.S.; Kudryavtsev, V.G.; Sulygin, I.I.

    1992-01-01

    To accelerate a high-intensity proton beam, 7 MV and 12 MV RF voltage per turn is required for the first and second rings of the UNK, respectively. The accelerating structure is developed following the modular principle. Each unit consists of two cylinder-shaped single-cell cavities which are fed by their own 850 KW RF power amplifier via a 3 dB hybrid. The first ring of the UNK contains 8 RF units, the second one contains 16 RF units. All RF equipment with the exception of a power amplifiers designed and being manufactured at IHEP. The results of the unit tests made at the lab are described. (author) 7 refs.; 3 figs.; 1 tab

  12. The influence of dietary patterns on acne vulgaris in Koreans.

    Science.gov (United States)

    Jung, Jae Yoon; Yoon, Mi Young; Min, Seong Uk; Hong, Jong Soo; Choi, Yu Sung; Suh, Dae Hun

    2010-01-01

    The association between acne and food has been evaluated with inconsistent results. We enrolled 783 patients with acne and 502 control subjects. For the patients with acne, blood tests for insulin, insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), post prandial 2 hours blood glucose (PP2), and dehydroepiandrosterone sulphate (DHEAS) were performed. The acne patients were divided into an "aggravated by food" group (AF) and a "not aggravated by food" group (NAF). All participants were asked to fill out a questionnaire. The frequency of vegetables (yellow, green leafy, cruciferous) (P = .001) and fish (white flesh and green fish, blue tuna) ((P = .03) intake was significantly higher in the control group than in the acne group. Intake of instant noodles (P = .01), junk food (P = .002), carbonated drinks (P = .005), snacks (P = .001), processed cheeses (P = .04), pork (braised) (P = .02), pork (roast) (P < .001), chicken (fried) (P = .001), chicken (stewed) (P = .001), nuts (P = .002) and seaweed (P = .003) were significantly higher in the acne patients than in the controls. Intake of roast pork (P = .02), fried chicken (P < .02), and nuts (P = .03) was significantly higher in the AF than NAF. In addition, the regularity of inter-meal intervals (P < .001) and breakfast intake (P < .001) were significantly lower in the acne patients. IGF-1 and IGFBP-3 showed sexual differences. This study also showed that a high glycemic load diet, dairy food intake, high fat diet, and iodine in Korean foods appear to play a role in acne exacerbation. In addition, irregular dietary patterns were found to aggravate acne.

  13. Erythema-directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris.

    Science.gov (United States)

    Micali, G; Dall'Oglio, F; Tedeschi, A; Lacarrubba, F

    2018-01-31

    Erythema-directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments. Here, we describe three case reports in which erythema-directed digital photography was used to evaluate acne before and after up to 12 weeks of treatment with clindamycin 1%/tretinoin 0.025% (Clin-RA). Erythema-directed digital photography was used to evaluate acne in three patients with mild-to-moderate facial acne, two of whom had refused to continue previous topical acne treatment (benzoyl peroxide 5% and clindamycin 1%/benzoyl peroxide 5%) due to persistent irritation. Acne lesions and erythema were evaluated using standard clinical photography and erythema-directed digital photography (VISIA-CR ™ system) before and after 8-12 weeks of treatment with Clin-RA. Erythema-directed digital photography revealed background erythema from previous topical acne treatments that was not evident from standard clinical photographs and allowed a better visualization of both inflammatory and non-inflammatory lesions. In all patients, there was a clear improvement in background erythema and a reduction in acne lesions following treatment with Clin-RA. This study has demonstrated for the first time that erythema-directed digital photography can enhance the evaluation of the efficacy and tolerability of topical acne treatments. These cases show that Clin-RA was associated with improved efficacy and tolerability vs previous treatments with topical monotherapy (benzoyl peroxide 5%) or a topical fixed-dose combination (clindamycin 1%/benzoyl peroxide 5%). © 2018 The Authors. Skin Research and Technology Published by John Wiley & Sons Ltd.

  14. Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris.

    Science.gov (United States)

    Borovaya, Alena; Dombrowski, Yvonne; Zwicker, Stephanie; Olisova, Olga; Ruzicka, Thomas; Wolf, Ronald; Schauber, Jürgen; Sárdy, Miklós

    2014-10-01

    In acne vulgaris, antimicrobial peptides (AMPs) could play a dual role; i.e., protective by acting against Propionibacterium acnes, pro-inflammatory by acting as signalling molecules. The cutaneous expression of 15 different AMPs was investigated in acne patients; furthermore, the impact of isotretinoin therapy on AMP expression was analysed in skin biopsies from 13 patients with acne vulgaris taken before, during and after a 6-month treatment cycle with isotretinoin using quantitative real-time polymerase chain reaction. Cutaneous expression of the AMPs cathelicidin, human β-defensin-2 (HBD-2), lactoferrin, lysozyme, psoriasin (S100A7), koebnerisin (S100A15), and RNase 7 was upregulated in untreated acne vulgaris, whereas α-defensin-1 (HNP-1) was downregulated compared to controls. While relative expression levels of cathelicidin, HBD-2, lactoferrin, psoriasin (S100A7), and koebnerisin (S100A15) decreased during isotretinoin treatment, only those of cathelicidin and koebnerisin returned to normal after 6 months of isotretinoin therapy. The increased expression of lysozyme and RNase 7 remained unaffected by isotretinoin treatment. The levels of granulysin, RANTES (CCL5), perforin, CXCL9, substance P, chromogranin B, and dermcidin were not regulated in untreated acne patients and isotretinoin had no effect on these AMPs. In conclusion, the expression of various AMPs is altered in acne vulgaris. Isotretinoin therapy normalizes the cutaneous production of distinct AMPs while the expression of others is still increased in healing acne. Considering the antimicrobial and pro-inflammatory role of AMPs, these molecules could serve as specific targets for acne therapy and maintenance of clinical remission.

  15. Evaluation of leptin, adiponectin, and ghrelin levels in patients with acne vulgaris.

    Science.gov (United States)

    Ozuguz, P; Kacar, S D; Asik, G; Ozuguz, U; Karatas, S

    2016-02-09

    The research evaluating adipokines are very few in patients with acne vulgaris. The hypothesis that hyperinsulinemic and high glycemic index diet plays a role in the pathogenesis of acne is still controversial. In this study, we aimed to evaluate adipokines such as leptin (L), adiponectin (A), ghrelin and A levels, and A/L rates that indicate insulin resistance in nonobese patients with severe acne vulgaris. Thirty patients who are nonobese with moderate acne vulgaris, aged 18 to 25 years, and 15 age-sex compatible controls were included in our study. The acne lesions were assessed using the Global Acne Grading Scale (GAGS). All participants were evaluated for the parameters that may affect the metabolism of serum L, A, and ghrelin levels in blood, and their body mass index were calculated. The significance level was determined as p ≤ 0.05. Of the 30 patients, 17 were women and 13 were men. The mean age was 20.60 years and the mean duration of the disease were 2.8 years. All of patients had moderate acne vulgaris (GAGS 19-30). Of the 15 controls, 11 were women and 4 were men. The mean age was 21.20 years. There were not a statistically significant difference in L, ghrelin, A levels, and A/L ratio between the two groups. Adipokines may have a role in the pathogenesis of acne vulgaris. L, A, ghrelin, and insulin resistance may not participate in the responsible mechanisms in nonobese patients with moderate acne vulgaris. © The Author(s) 2016.

  16. Quality of life, self-esteem and psychosocial factors in adolescents with acne vulgaris.

    Science.gov (United States)

    Vilar, Gustavo Nunes; Santos, Laís Araújo dos; Sobral Filho, Jader Freire

    2015-01-01

    Dermatological diseases, among which acne vulgaris, have psychological impact on the affected generating feelings of guilt, shame and social isolation. To compare quality of life, self-esteem and other psychosocial variables amongst adolescents with and without acne vulgaris, and between levels of severity. Cross-sectional observational study in a sample of 355 high school students from the city of João Pessoa. Data collection was performed with questionnaires and clinical-dermatological evaluation. The primary variables were the incidence of AV; quality of life, set by the Children's Dermatology Quality of Life Index and Dermatology Quality of Life Index; and self-esteem, measured by the Rosenberg Self-Esteem Scale. For calculation of statistical tests, we used the SPSS 20.0 software, considering p=0.05. The sample, with an average age of 16, showed 89.3% prevalence of acne vulgaris. The most prevalent psychosocial issue was "afraid that acne will never cease", present in 58% of affected youth. The median score of Quality of Life in Children's Dermatology Index was different amongst students with and without acne vulgaris (p=0.003), as well as the Quality of Life in Dermatology (p=0.038) scores, so that students with acne vulgaris have worse QoL. There was a correlation between the severity of acne vulgaris and worse quality of life. Self-esteem was not significantly associated with the occurrence or severity of acne vulgaris. acne vulgaris assumes significance in view of its high prevalence and the effect on quality of life of adolescents, more severe at the more pronounced stages of disease (pacne vulgaris should be valued in the management of patients with this condition.

  17. Improving adherence to acne treatment: the emerging role of application software

    Directory of Open Access Journals (Sweden)

    Park C

    2014-02-01

    Full Text Available Chanhyun Park,1 Gilwan Kim,1 Isha Patel,2 Jongwha Chang,3 Xi Tan2 1College of Pharmacy, University of Texas at Austin, Austin, TX, USA; 2College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 3McWhorter School of Pharmacy, Samford University, Birmingham, AL, USA Objective: To examine recent studies on the effect of mobile and electronic (ME-health technology on adherence to acne treatment. Background: With emerging use of ME-health technology, there is a growing interest in evaluating the effectiveness of the tools on medication adherence. Examples of ME-health technology-based tools include text message-based pill reminders and Web-based patient education. Methods: MEDLINE, Cochrane Library, and Web of Science were searched for articles on adherence to acne treatment published through November 2013. A combination of search terms such as "acne" and "adherence" or "compliance" were used. Results: Adherence to oral acne medication was higher than for topical acne medication. The frequency of office visits was also an influencing factor for acne treatment adherence. The telephone-based reminders on a daily basis did not improve acne patients' medication adherence, whereas the Web-based educational tools on a weekly basis had a positive effect on medication adherence in acne treatment. Conclusion: In using ME-health interventions, factors such as medication dosage forms, frequency of intervention, and patients' preferences should be taken into consideration. Developing disease-specific text message reminders may be helpful to increase adherence rates. In addition, a combination of text message reminders with another type of intervention may improve medication adherence. Keywords: acne vulgaris, medication adherence, compliance, mobile and electronic health technology, application software, telemedicine

  18. Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne.

    Science.gov (United States)

    Ben-Amitai, D; Laron, Z

    2011-08-01

    The role of growth hormone, insulin, and insulin-like growth factor-1 (IGF-1) in the development of acne is incompletely understood. To study the effect of the absence of IGF-1 and its pharmacologic replacement on the occurrence of acne vulgaris. Laron syndrome (LS) is characterized by congenital IGF-1 deficiency. The study group consisted of 21 patients with classical LS, who underwent puberty: 13 (8 male, 5 female) untreated and under regular follow-up until age 20?48 years; and 8 (2 male, 6 female) treated with IGF-1 (70-200 μg/kg/day), including 6 adults (2 male, treated at age 14.5-29 years and 4 female, treated at age 30-37 years) and 2 adolescents (2 female, treated at age 3.5-16 years). The medical files were reviewed for occurrence of acne and the corresponding sex hormone levels, and the findings were compared between the treated and untreated patients. Puberty was delayed in all untreated patients. Only one patient had slight acne at age 22 years, when he reached full puberty. Among the 2 IGF-1 treated male patients, none acquired acne. Among the 6 treated female patients, 3 had signs of hyperandrogenism (oligo-amenorrhea) and acne during IGF-1 over-dosage. On reduction of the IGF-1 dose (to 50 μg/kg/day) or cessation of treatment, the acne disappeared in all 3 patients. This study demonstrates for the first time that serum IGF-1 deficiency prevents the occurrence of acne. The findings suggest that an interaction between IGF-1 and androgens is necessary for the development of acne. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

  19. Chronic prostatic infection and inflammation by Propionibacterium acnes in a rat prostate infection model.

    Science.gov (United States)

    Olsson, Jan; Drott, Johanna Bergh; Laurantzon, Lovisa; Laurantzon, Oscar; Bergh, Anders; Elgh, Fredrik

    2012-01-01

    Chronic inflammation in the prostate, seen as infiltration of inflammatory cells into the prostate gland in histological samples, affects approximately half the male population without indication of prostate disease, and is almost ubiquitous in patients diagnosed with benign prostate hyperplasia and cancer. Several studies have demonstrated the gram-positive bacterium Propionibacterium acnes to be frequently present in prostate tissue from men suffering from prostate disease. P. acnes has been shown to be associated with histological inflammation in human prostatectomy specimens, and also to induce strong inflammatory response in prostate-derived tissue culture models. The present paper describes a rat model for assessment of the pathogenic potential of P. acnes in prostate. Prostate glands of Sprague Dawley rats (n = 98) were exposed via an abdominal incision and live P. acnes or, in control rats, saline were injected into the ventral and dorso-lateral lobes. Rats were sacrificed 5 days, 3 weeks, 3 months and 6 months post infection, and prostate tissue was analyzed for bacterial content and histological inflammation. Rat sera were assessed for levels of CRP and anti-P. acnes IgG. Live P. acnes could be recovered from the dorso-lateral lobes up to 3 months post infection, while the ventral lobes were cleared from bacteria at that time. In samples up to 3 months post infection, the dorso-lateral lobes exhibited intense focal inflammation. CRP and IgG levels were elevated throughout the span of the experiment, and reached maximum levels 3 weeks and 3 months post infection, respectively. We show that P. acnes have the potential to cause chronic infection in previously healthy prostate, and that the infection has potential to cause chronic histological inflammation in the infected tissue. The high prevalence of P. acnes in human prostate tissue calls for resolution of pathogenic details. The present rat model suggests that complications such as chronic

  20. Propionibacterium acnes in shoulder surgery: is loss of hair protective for infection?

    Science.gov (United States)

    Hudek, Robert; Sommer, Frank; Abdelkawi, Ayman F; Kerwat, Martina; Müller, Hans-Helge; Gohlke, Frank

    2016-06-01

    Propionibacterium acnes (P acnes) has been linked to chronic infections in shoulder surgery. It was recently observed during first-time shoulder surgery in healthy patients at a rate between 36% and 56%. Male gender and the anterolateral approach were reported risk factors. Because the skin biology greatly differs, we aimed to correlate skin complaints with P acnes-positive intraoperative cultures from different tissue layer samples in patients undergoing shoulder surgery for the first time. Intraoperative samples (1 skin, 1 superficial, 1 deep tissue, and 1 control sample) from 112 patients (70 men, 42 women; aged 59.2 years) were cultured. The association between the presence of P acnes in the deep or superficial tissue, or both, and 10 items of a validated preoperative questionnaire for skin pathology was explored. The cultures were positive for P acnes in 38.4% (n = 43) of the cases. Skin samples were positive for P acnes in 8% (n = 9), superficial samples were positive in 23% (n = 26), and deep samples were positive in 30% (n = 34). Self-reported "loss of hair" was significantly negatively associated with the presence of P acnes in the superficial or deep tissue sample (P = .00028). Patients who report having "loss of hair" show fewer P acnes-positive cultures in intraoperative tissue samples taken during open shoulder surgery. Whether this subgroup is at a lesser risk for P acnes infections remains to be substantiated. Basic Science Study; Microbiology. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.