DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.

NARCIS (Netherlands)

B.J. Glassner (Brian); G. Weeda (Geert); J.M. Allan (James); J.L.M. Broekhof (Jose'); N.H.E. Carls (Nick); I. Donker (Ingrid); B.P. Engelward (Bevin); R.J. Hampson (Richard); R. Hersmus (Remko); M.J. Hickman (Mark); R.B. Roth (Richard); H.B. Warren (Henry); M.M. Wu (Mavis); J.H.J. Hoeijmakers (Jan); L.D. Samson (Leona)

1999-01-01

textabstractWe have generated mice deficient in O6-methylguanine DNA methyltransferase activity encoded by the murine Mgmt gene using homologous recombination to delete the region encoding the Mgmt active site cysteine. Tissues from Mgmt null mice displayed very low O6-methylguanine DNA

Research on DNA methylation of human osteosarcoma cell MGMT and its relationship with cell resistance to alkylating agents.

Science.gov (United States)

Guo, Jun; Cui, Qiu; Jiang, WeiHao; Liu, Cheng; Li, DingFeng; Zeng, Yanjun

2013-08-01

The objective of this study was to explore the O(6)-methylguanine-DNA methyltransferase (MGMT) gene methylation status and its protein expression, as well as the effects of demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-CdR) on MGMT gene expression and its resistance to alkylating agents, and to elucidate MGMT expression mechanism and significance in osteosarcoma. The human osteosarcoma cell lines Saos-2 and MG-63 were collected and treated with 5-Aza-CdR for 6 days. The cells not treated with 5-Aza-CdR were set as a negative control. The genomic DNA was extracted from the Saos-2 and MG-63 cells using methylation-specific PCR to detect the promoter CpG island methylation status of the MGMT gene. Cell sensitivity to alkylating agents before and after drug administration was detected by the MTT method. The variation in MGMT gene mRNA and protein was detected by reverse transcription PCR (RT-PCR) and Western blotting. The MGMT promoter gene of normal Saos-2 cells was methylated, with reduced MGMT mRNA and protein expression; the MGMT mRNA and protein expression of Saos-2 cells treated with 5-Aza-CdR was obviously enhanced, and its sensitivity to alkylating agents was reversed. Meanwhile, with promoter CpG island unmethylation of the MGMT gene, MGMT protein was expressed in the normal MG-63 cells and the MG-63 cells treated with 5-Aza-CdR, and both showed resistance to alkylating agents. The methylation status of the MGMT gene promoter in human osteosarcoma cells reflected the cells' ability to induce MGMT protein expression and can be used as a molecular marker to project the sensitivity of cancer tissues to alkylating agent drugs.

Different diagnostic values of imaging parameters to predict pseudoprogression in glioblastoma subgroups stratified by MGMT promoter methylation

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Yoon, Ra Gyoung [Catholic Kwandong University International St. Mary' s Hospital, Department of Radiology, Catholic Kwandong University College of Medicine, Incheon (Korea, Republic of); Kim, Ho Sung; Shim, Woo Hyun; Kim, Sang Joon [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Paik, Wooyul [Dankook Unversity Hospital, Department of Radiology, Cheonan-si, Chungcheongnam-do (Korea, Republic of); Kim, Jeong Hoon [University of Ulsan College of Medicine, Asan Medical Center, Department of Neurosurgery, Seoul (Korea, Republic of)

2017-01-15

The aim of this study was to determine whether diffusion and perfusion imaging parameters demonstrate different diagnostic values for predicting pseudoprogression between glioblastoma subgroups stratified by O{sup 6}-mythylguanine-DNA methyltransferase (MGMT) promoter methylation status. We enrolled seventy-five glioblastoma patients that had presented with enlarged contrast-enhanced lesions on magnetic resonance imaging (MRI) one month after completing concurrent chemoradiotherapy and undergoing MGMT promoter methylation testing. The imaging parameters included 10 or 90 % histogram cutoffs of apparent diffusion coefficient (ADC10), normalized cerebral blood volume (nCBV90), and initial area under the time signal-intensity curve (IAUC90). The results of the areas under the receiver operating characteristic curve (AUCs) with cross-validation were compared between MGMT methylation and unmethylation groups. MR imaging parameters demonstrated a trend toward higher accuracy in the MGMT promoter methylation group than in the unmethylation group (cross-validated AUCs = 0.70-0.95 and 0.56-0.87, respectively). The combination of MGMT methylation status with imaging parameters improved the AUCs from 0.70 to 0.75-0.90 for both readers in comparison with MGMT methylation status alone. The probability of pseudoprogression was highest (95.7 %) when nCBV90 was below 4.02 in the MGMT promoter methylation group. MR imaging parameters could be stronger predictors of pseudoprogression in glioblastoma patients with the methylated MGMT promoter than in patients with the unmethylated MGMT promoter. (orig.)

Volumetric and MGMT parameters in glioblastoma patients: Survival analysis

International Nuclear Information System (INIS)

Iliadis, Georgios; Kotoula, Vassiliki; Chatzisotiriou, Athanasios; Televantou, Despina; Eleftheraki, Anastasia G; Lambaki, Sofia; Misailidou, Despina; Selviaridis, Panagiotis; Fountzilas, George

2012-01-01

In this study several tumor-related volumes were assessed by means of a computer-based application and a survival analysis was conducted to evaluate the prognostic significance of pre- and postoperative volumetric data in patients harboring glioblastomas. In addition, MGMT (O 6 -methylguanine methyltransferase) related parameters were compared with those of volumetry in order to observe possible relevance of this molecule in tumor development. We prospectively analyzed 65 patients suffering from glioblastoma (GBM) who underwent radiotherapy with concomitant adjuvant temozolomide. For the purpose of volumetry T1 and T2-weighted magnetic resonance (MR) sequences were used, acquired both pre- and postoperatively (pre-radiochemotherapy). The volumes measured on preoperative MR images were necrosis, enhancing tumor and edema (including the tumor) and on postoperative ones, net-enhancing tumor. Age, sex, performance status (PS) and type of operation were also included in the multivariate analysis. MGMT was assessed for promoter methylation with Multiplex Ligation-dependent Probe Amplification (MLPA), for RNA expression with real time PCR, and for protein expression with immunohistochemistry in a total of 44 cases with available histologic material. In the multivariate analysis a negative impact was shown for pre-radiochemotherapy net-enhancing tumor on the overall survival (OS) (p = 0.023) and for preoperative necrosis on progression-free survival (PFS) (p = 0.030). Furthermore, the multivariate analysis confirmed the importance of PS in PFS and OS of patients. MGMT promoter methylation was observed in 13/23 (43.5%) evaluable tumors; complete methylation was observed in 3/13 methylated tumors only. High rate of MGMT protein positivity (> 20% positive neoplastic nuclei) was inversely associated with pre-operative tumor necrosis (p = 0.021). Our findings implicate that volumetric parameters may have a significant role in the prognosis of GBM patients. Furthermore

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

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Fahrer, Jörg; Frisch, Janina; Nagel, Georg; Kraus, Alexander; Dörsam, Bastian; Thomas, Adam D; Reißig, Sonja; Waisman, Ari; Kaina, Bernd

2015-10-01

Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated base excision repair, respectively. In view of recent evidence of nonlinear mutagenicity for NOC-like compounds, the question arises as to the existence of threshold doses in CRC formation. Here, we set out to determine the impact of DNA repair on the dose-response of alkylation-induced CRC. DNA repair proficient (WT) and deficient (Mgmt (-/-), Aag (-/-) and Mgmt (-/-)/Aag (-/-)) mice were treated with azoxymethane (AOM) and dextran sodium sulfate to trigger CRC. Tumors were quantified by non-invasive mini-endoscopy. A non-linear increase in CRC formation was observed in WT and Aag (-/-) mice. In contrast, a linear dose-dependent increase in tumor frequency was found in Mgmt (-/-) and Mgmt (-/-)/Aag (-/-) mice. The data were corroborated by hockey stick modeling, yielding similar carcinogenic thresholds for WT and Aag (-/-) and no threshold for MGMT lacking mice. O (6)-MeG levels and depletion of MGMT correlated well with the observed dose-response in CRC formation. AOM induced dose-dependently DNA double-strand breaks in colon crypts including Lgr5-positive colon stem cells, which coincided with ATR-Chk1-p53 signaling. Intriguingly, Mgmt (-/-) mice displayed significantly enhanced levels of γ-H2AX, suggesting the usefulness of γ-H2AX as an early genotoxicity marker in the colorectum. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG, as a key node in determining a carcinogenic threshold. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults.

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Alvarez, Marisa C; Santos, Juliana C; Maniezzo, Nathália; Ladeira, Marcelo S; da Silva, Artur L C; Scaletsky, Isabel C A; Pedrazzoli, José; Ribeiro, Marcelo L

2013-05-28

To evaluate the association between Helicobacter pylori (H. pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability (MSI). The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction (MSP-PCR) in gastric biopsy samples from uninfected or H. pylori-infected children (n = 50), from adults with chronic gastritis (n = 97) and from adults with gastric cancer (n = 92). MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene (β actin). MSI analysis was performed by screening MSI markers at 4 loci (Bat-25, Bat-26, D17S250 and D2S123) with PCR; PCR products were analysed by single strand conformation polymorphism followed by silver staining. Statistical analyses were performed with either the χ(2) test with Yates continuity correction or Fisher's exact test, and statistical significance for expression analysis was assessed using an unpaired Student's t-test. Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children, regardless of H. pylori infection status. The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H. pylori infection (P MLH1 methylation frequencies among H. pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%, respectively. We observed methylation of the MLH1 promoter (39%) and increased MSI levels (68%) in samples from gastric cancer patients in comparison to samples from H. pylori-infected adult chronic gastritis patients (P MLH1 and MGMT mRNA were significantly reduced in chronic gastritis samples that were also hypermethylated (P MLH1 methylation did not occur in earlier-stage H. pylori infections and thus might depend on the duration of infection.

Expression and relevant research of MGMT and XRCC1 gene in differentgrades of brain glioma and normal brain tissues

Institute of Scientific and Technical Information of China (English)

Ya-Fei Zhang

2015-01-01

Objective: To explore and analyze expression and relevant research of MGMT and XRCC1 gene in different grades of brain glioma and normal brain tissues. Methods: 52 cases of patients with brain glioma treated in our hospital from December 2013 to December 2014, and 50 cases of normal brain-tissue patients with intracranial hypertension were selected, and proceeding test to the surgical resection of brain tissue of the above patients to determine its MGMT and XRCC1 protein content, sequentially to record the expression of MGMT and XRCC1 of both groups. Grading of tumors to brain glioma after operation was carried out, and the expression of MGMT and XRCC1 gene in brain tissues of different patients was analyzed and compared;finally the contingency tables of X2 test was used to analyze the correlation of XRCC1and MGMT. Results:Positive rate of MGMT expression in normal brain tissue was 2%,while positive rate of MGMT expression in brain glioma was 46.2%,which was obviously higher than that in normal brain tissues (χ2=26.85, P0.05), which had no statistical significance. There were 12 cases of patients whose MGMT protein expression was positive and XRCC1 protein expression was positive; there were 18 cases of patients whose MGMT protein expression was negative and XRCC1 protein expression was negative. Contingency tables of X2 test was used to analyze the correlation of XRCC1 and MGMT, which indicated that the expression of XRCCI and MGMT in brain glioma had no correlation (r=0.9%, P=0.353), relevancy of both was r=0.9%. Conclusions: Positive rate of the expression of MGMT and XRCC1 in brain glioma was obviously higher than that in normal brain tissues, but the distribution of different grades of brain glioma had no obvious difference, and MGMT and XRCC1 expression had no obvious correlation, which needed further research.

Prognostic value of O‐6‐methylguanine–DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis

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Dahlrot, Rikke H; Dowsett, Joseph; Fosmark, Sigurd

2018-01-01

AIMS: It is important to predict response to treatment with temozolomide (TMZ) in glioblastoma (GBM) patients. Both MGMT protein expression and MGMT promoter methylation have been reported to predict the response to TMZ. We investigated the prognostic value of quantified MGMT protein levels...... in tumour cells and the prognostic importance of combining information of MGMT protein level and MGMT promoter methylations status. METHODS: MGMT protein expression was quantified in tumour cells in 171 GBMs from the population-based Region of Southern Denmark (RSD)-cohort using a double immunofluorescence...... approach. Pyrosequencing was performed in 157 patients. For validation we used GBM-patients from a Nordic Study (NS) investigating the effect of radiotherapy and different TMZ schedules. RESULTS: When divided at the median, patients with low expression of MGMT protein (AF-low) had the best prognosis (HR 1...

The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma

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Veronica Villani

2015-01-01

Full Text Available O6-methylguanine-DNA-methyltransferase (MGMT has emerged as a relevant predictor of therapeutic response and good prognosis in patients with glioblastoma (GBM. Transcriptionally active MGMT rapidly removes the alkyl adducts, preventing the formation of cross-links and thereby causing resistance to alkylating drugs. Studies with pyrosequencing (PSQ showed that this technique has a higher reproducibility and sensitivity than other techniques. However, the definition of a prognostically relevant threshold for the percentage of MGMT methylation remains one of the most critical issues in the use of PSQ analysis. The aim of this study was to define the cut-off value correlated with good favourable prognostic outcomes. We retrospectively analyzed 51 patients (33 males, 18 females with GBM who underwent surgery or biopsy. The Receiver Operating Characteristics analysis showed that the best possible criteria for PSQ-detected percentage of MGMT methylation that predicted progression-free survival (PFS and overall survival (OS were 19% and 13%, respectively. Patients with ≤19% of PSQ-detected MGMT had a shorter PFS (HR: 0.24, p<0.01; those ones with ≤13% had a shorter OS (HR: 0.33, p<0.05. Our study reinforces the importance of MGMT in the management of GBM patients, but future studies with larger sample sizes are warranted to confirm our findings.

Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.

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João Ramalho-Carvalho

Full Text Available MGMT downregulation in high-grade gliomas (HGG has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to alkylating agent-based chemotherapy. However, HGG harboring 10q deletions also benefit from treatment with alkylating agents. Because the MGMT gene is mapped at 10q26, we hypothesized that both epigenetic and genetic alterations might affect its expression and predict response to chemotherapy. To test this hypothesis, promoter methylation and mRNA levels of MGMT were determined by quantitative methylation-specific PCR (qMSP or methylation-specific multiplex ligation dependent probe amplification (MS-MLPA and quantitative RT-PCR, respectively, in a retrospective series of 61 HGG. MGMT/chromosome 10 copy number variations were determined by FISH or MS-MLPA analysis. Molecular findings were correlated with clinical parameters to assess their predictive value. Overall, MGMT methylation ratios assessed by qMSP and MS-MLPA were inversely correlated with mRNA expression levels (best coefficient value obtained with MS-MLPA. By FISH analysis in 68.3% of the cases there was loss of 10q26.1 and in 15% of the cases polysomy was demonstrated; the latter displayed the highest levels of transcript. When genetic and epigenetic data were combined, cases with MGMT promoter methylation and MGMT loss depicted the lowest transcript levels, although an impact in response to alkylating agent chemotherapy was not apparent. Cooperation between epigenetic (promoter methylation and genetic (monosomy, locus deletion changes affecting MGMT in HGG is required for effective MGMT silencing. Hence, evaluation of copy number alterations might add relevant prognostic and predictive information concerning response to alkylating agent-based chemotherapy.

Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

OpenAIRE

Jue, Toni Rose; Nozue, Kyoko; Lester, Ashleigh J.; Joshi, Swapna; Schroder, Lisette B. W.; Whittaker, Shane P.; Nixdorf, Sheri; Rapkins, Robert W.; Khasraw, Mustafa; McDonald, Kerrie L.

2017-01-01

Background The O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive to the standard treatment regime of surgery followed by concurrent radiotherapy (RT) and temozolomide. Here, we investigate the efficacy of adding a PARP inhibitor, veliparib, to radiotherapy to treat MGMT unmethylated GBM. Methods The inhibition of PARP with veliparib (ABT-888), a potent and orally bioavailable inhibitor in combination ...

MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma

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Skiriute Daina

2012-06-01

Full Text Available Abstract Background Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epigenetic markers and evaluate its separate and concomitant role in glioblastoma genesis and patient outcome. Methods The methylation status of MGMT, CD81, GATA6, DR4, and CASP8 in 76 patients with primary glioblastomas was investigated. Methylation-specific PCR reaction was performed using bisulfite treated DNA. Evaluating glioblastoma patient survival time after operation, patient data and gene methylation effect on survival was estimated using survival analysis. Results The overwhelming majority (97.3% of tumors were methylated in at least one of five genes tested. In glioblastoma specimens gene methylation was observed as follows: MGMT in 51.3%, GATA6 in 68.4%, CD81 in 46.1%, DR4 in 41.3% and CASP8 in 56.8% of tumors. Methylation of MGMT was associated with younger patient age (p CASP8 with older (p MGMT methylation was significantly more frequent event in patient group who survived longer than 36 months after operation (p CASP8 was more frequent in patients who survived shorter than 36 months (p MGMT, GATA6 and CASP8 as independent predictors for glioblastoma patient outcome (p MGMT and GATA6 were independent predictors for patient survival in younger patients’ group, while there were no significant associations observed in older patients’ group when adjusted for therapy. Conclusions High methylation frequency of tested genes shows heterogeneity of glioblastoma epigenome and the importance of MGMT, GATA6 and CASP8 genes methylation in glioblastoma patient outcome.

Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells

International Nuclear Information System (INIS)

Cheng, Jin; Ye, Feng; Dan, Guorong; Zhao, Yuanpeng; Wang, Bin; Zhao, Jiqing; Sai, Yan; Zou, Zhongmin

2016-01-01

Nitrogen mustard (NM), a bifunctional alkylating agent (BAA), contains two alkyl arms and can act as a cross-linking bridge between DNA and protein to form a DNA-protein cross-link (DPC). O 6 -methylguanine–DNA methyltransferase (MGMT), a DNA repair enzyme for alkyl adducts removal, is found to enhance cell sensitivity to BAAs and to promote damage, possibly due to its stable covalent cross-linking with DNA mediated by BAAs. To investigate MGMT-DNA cross-link (mDPC) formation and its possible dual roles in NM exposure, human bronchial epithelial cell line 16HBE was subjected to different concentrations of HN2, a kind of NM, and we found mDPC was induced by HN2 in a concentration-dependent manner, but the mRNA and total protein of MGMT were suppressed. As early as 1 h after HN2 treatment, high mDPC was achieved and the level maintained for up to 24 h. Quick total DPC (tDPC) and γ-H2AX accumulation were observed. To evaluate the effect of newly predicted protease DVC1 on DPC cleavage, we applied siRNA of MGMT and DVC1, MG132 (proteasome inhibitor), and NMS-873 (p97 inhibitor) and found that proteolysis plays a role. DVC1 was proven to be more important in the cleavage of mDPC than tDPC in a p97-dependent manner. HN2 exposure induced DVC1 upregulation, which was at least partially contributed to MGMT cleavage by proteolysis because HN2-induced mDPC level and DNA damage was closely related with DVC1 expression. Homologous recombination (HR) was also activated. Our findings demonstrated that MGMT might turn into a DNA damage promoter by forming DPC when exposed to HN2. Proteolysis, especially DVC1, plays a crucial role in mDPC repair. - Highlights: • Nitrogen mustard-induced MGMT-DNA cross-linking was detected in a living cell. • Concentration- and time-dependent manners of MGMT-DNA cross-linking were revealed. • Proteolysis played an important role in protein (MGMT)-DNA cross-linking repair. • DVC1 acts as a proteolytic enzyme in cross-linking repair in a p

MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response.

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Switzeny, Olivier J; Christmann, Markus; Renovanz, Mirjam; Giese, Alf; Sommer, Clemens; Kaina, Bernd

2016-01-01

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are routinely treated with alkylating drugs. Since MGMT is highly epigenetically regulated, the MGMT promoter methylation status is taken as an indicator of MGMT silencing, predicting the outcome of glioma therapy. MGMT promoter methylation is usually determined by methylation specific PCR (MSP), which is a labor intensive and error-prone method often used semi-quantitatively. Searching for alternatives, we used closed-tube high resolution melt (HRM) analysis, which is a quantitative method, and compared it with MSP and pyrosequencing regarding its predictive value. We analyzed glioblastoma cell lines with known MGMT activity and formalin-fixed samples from IDH1 wild-type high-grade glioma patients (WHO grade III/IV) treated with radiation and temozolomide by HRM, MSP, and pyrosequencing. The data were compared as to progression-free survival (PFS) and overall survival (OS) of patients exhibiting the methylated and unmethylated MGMT status. A promoter methylation cut-off level relevant for PFS and OS was determined. In a multivariate Cox regression model, methylation of MGMT promoter of high-grade gliomas analyzed by HRM, but not MSP, was found to be an independent predictive marker for OS. Univariate Kaplan-Meier analyses revealed for PFS and OS a significant and better discrimination between methylated and unmethylated tumors when quantitative HRM was used instead of MSP. Compared to MSP and pyrosequencing, the HRM method is simple, cost effective, highly accurate and fast. HRM is at least equivalent to pyrosequencing in quantifying the methylation level. It is superior in predicting PFS and OS of high-grade glioma patients compared to MSP and, therefore, can be recommended being used routinely for determination of the MGMT status of gliomas.

O6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C

International Nuclear Information System (INIS)

Passagne, Isabelle; Evrard, Alexandre; Depeille, Philippe; Cuq, Pierre; Cupissol, Didier; Vian, Laurence

2006-01-01

Alkylating agents play an important role in the chemotherapy of malignant melanomas. The activity of alkylating agents depends on their capacity to form alkyl adducts with DNA, in some cases causing cross-linking of DNA strands. However, the use of these agents is limited by cellular resistance induced by the DNA repair enzyme O 6 -methylguanine DNA-methyltransferase (MGMT) which removes alkyl groups from alkylated DNA strands. To determine to what extent the expression of MGMT in melanoma cells induces resistance to alkylating agents, the human cell line CAL77 Mer- (i.e., MGMT deficient) were transfected with pcMGMT vector containing human MGMT cDNA. Several clones expressing MGMT at a high level were selected to determine their sensitivity to chemotherapeutic drugs. Melanoma-transfected cells were found to be significantly less sensitive to nitrosoureas (carmustine, fotemustine, streptozotocin) and temozolomide with an increase of IC 5 values between 3 and 14 when compared to parent cells. No difference in cell survival rates between MGMT-proficient and -deficient cells was observed for melphalan, chlorambucil, busulphan, thiotepa and cisplatin which preferentially induce N 7 guanine lesions. Surprisingly, MGMT overexpression increased the sensitivity of CAL77 cells to mitomycin C by approximately 10-fold. Treatment of clonal cell lines with buthionine-[S,R]-sulfoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase which depletes cellular glutathione, completely reversed this unexpected increase in sensitivity to mitomycin C. This observation suggests that glutathione is involved in the sensitivity of MGMT-transfected cells to mitomycin C and may act synergistically with MGMT via an unknown mechanism

O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.

Science.gov (United States)

Passagne, Isabelle; Evrard, Alexandre; Depeille, Philippe; Cuq, Pierre; Cupissol, Didier; Vian, Laurence

2006-03-01

Alkylating agents play an important role in the chemotherapy of malignant melanomas. The activity of alkylating agents depends on their capacity to form alkyl adducts with DNA, in some cases causing cross-linking of DNA strands. However, the use of these agents is limited by cellular resistance induced by the DNA repair enzyme O(6)-methylguanine DNA-methyltransferase (MGMT) which removes alkyl groups from alkylated DNA strands. To determine to what extent the expression of MGMT in melanoma cells induces resistance to alkylating agents, the human cell line CAL77 Mer- (i.e., MGMT deficient) were transfected with pcMGMT vector containing human MGMT cDNA. Several clones expressing MGMT at a high level were selected to determine their sensitivity to chemotherapeutic drugs. Melanoma-transfected cells were found to be significantly less sensitive to nitrosoureas (carmustine, fotemustine, streptozotocin) and temozolomide with an increase of IC(50) values between 3 and 14 when compared to parent cells. No difference in cell survival rates between MGMT-proficient and -deficient cells was observed for melphalan, chlorambucil, busulphan, thiotepa and cisplatin which preferentially induce N(7) guanine lesions. Surprisingly, MGMT overexpression increased the sensitivity of CAL77 cells to mitomycin C by approximately 10-fold. Treatment of clonal cell lines with buthionine-[S,R]-sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase which depletes cellular glutathione, completely reversed this unexpected increase in sensitivity to mitomycin C. This observation suggests that glutathione is involved in the sensitivity of MGMT-transfected cells to mitomycin C and may act synergistically with MGMT via an unknown mechanism.

Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide).

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Pandith, Arshad A; Qasim, Iqbal; Zahoor, Wani; Shah, Parveen; Bhat, Abdul R; Sanadhya, Dheera; Shah, Zafar A; Naikoo, Niyaz A

2018-04-30

O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation and its subsequent loss of protein expression has been identified to have a variable impact on clinical outcome of glioma patients indicated for chemotherapy with alkylating agents (Temozolomide). This study investigated methylation status of MGMT gene along with in situ protein expression in malignant glioma patients of different histological types to evaluate the associated clinical outcome vis-a-vis use of alkylating drugs and radiotherapy. Sixty three cases of glioma were evaluated for MGMT promoter methylation by methylation-specific PCR (MS-PCR) and protein expression by immunostaining (IHC). Methylation status of MGMT and loss of protein expression showed a very high concordant association with better survival and progression free survival (PFS) (p < 0.0001). Multivariate Cox regression analysis showed both MGMT methylation and loss of protein as significant independent prognostic factors in glioma patients with respect to lower Hazard Ratio (HR) for better OS and PFS) [p < 0.05]. Interestingly concordant MGMT methylation and lack of protein showed better response in TMZ therapy treated patient subgroups with HR of 2.02 and 0.76 (p < 0.05). We found the merits of prognostication of MGMT parameters, methylation as well as loss of its protein as predictive factors for favorable outcome in terms of better survival for TMZ therapy.

Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma

DEFF Research Database (Denmark)

Kristensen, Lasse S; Michaelsen, Signe R; Dyrbye, Henrik

2016-01-01

Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a predictive and prognostic marker in newly diagnosed glioblastoma patients treated with temozolomide but how MGMT methylation should be assessed to ensure optimal detection accuracy is debated. We developed a novel quanti...

Using the apparent diffusion coefficient to identifying MGMT promoter methylation status early in glioblastoma: importance of analytical method

Energy Technology Data Exchange (ETDEWEB)

Rundle-Thiele, Dayle [Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia); Day, Bryan; Stringer, Brett [Brain Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland (Australia); Fay, Michael [Department of Radiation Oncology, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Martin, Jennifer [Discipline of Clinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales (Australia); Jeffree, Rosalind L [Department of Neurosurgery, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Thomas, Paul [Queensland PET Service, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Bell, Christopher [Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia); Salvado, Olivier [CSIRO Digital Productivity Flagship, CSIRO, Herston, Queensland (Australia); Gal, Yaniv [Centre for Medical Diagnostic Technologies in Queensland, University of Queensland, Brisbane, Queensland (Australia); Coulthard, Alan [Discipline of Medical Imaging, University of Queensland, St Lucia, Queensland (Australia); Department of Medical Imaging, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Crozier, Stuart [Centre for Medical Diagnostic Technologies in Queensland, University of Queensland, Brisbane, Queensland (Australia); Rose, Stephen, E-mail: stephen.rose@csiro.au [CSIRO Digital Productivity Flagship, CSIRO, Herston, Queensland (Australia); Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia)

2015-06-15

Accurate knowledge of O{sup 6}-methylguanine methyltransferase (MGMT) gene promoter subtype in patients with glioblastoma (GBM) is important for treatment. However, this test is not always available. Pre-operative diffusion MRI (dMRI) can be used to probe tumour biology using the apparent diffusion coefficient (ADC); however, its ability to act as a surrogate to predict MGMT status has shown mixed results. We investigated whether this was due to variations in the method used to analyse ADC. We undertook a retrospective study of 32 patients with GBM who had MGMT status measured. Matching pre-operative MRI data were used to calculate the ADC within contrast enhancing regions of tumour. The relationship between ADC and MGMT was examined using two published ADC methods. A strong trend between a measure of ‘minimum ADC’ and methylation status was seen. An elevated minimum ADC was more likely in the methylated compared to the unmethylated MGMT group (U = 56, P = 0.0561). In contrast, utilising a two-mixture model histogram approach, a significant reduction in mean measure of the ‘low ADC’ component within the histogram was associated with an MGMT promoter methylation subtype (P < 0.0246). This study shows that within the same patient cohort, the method selected to analyse ADC measures has a significant bearing on the use of that metric as a surrogate marker of MGMT status. Thus for dMRI data to be clinically useful, consistent methods of data analysis need to be established prior to establishing any relationship with genetic or epigenetic profiling.

Using the apparent diffusion coefficient to identifying MGMT promoter methylation status early in glioblastoma: importance of analytical method

International Nuclear Information System (INIS)

Rundle-Thiele, Dayle; Day, Bryan; Stringer, Brett; Fay, Michael; Martin, Jennifer; Jeffree, Rosalind L; Thomas, Paul; Bell, Christopher; Salvado, Olivier; Gal, Yaniv; Coulthard, Alan; Crozier, Stuart; Rose, Stephen

2015-01-01

Accurate knowledge of O 6 -methylguanine methyltransferase (MGMT) gene promoter subtype in patients with glioblastoma (GBM) is important for treatment. However, this test is not always available. Pre-operative diffusion MRI (dMRI) can be used to probe tumour biology using the apparent diffusion coefficient (ADC); however, its ability to act as a surrogate to predict MGMT status has shown mixed results. We investigated whether this was due to variations in the method used to analyse ADC. We undertook a retrospective study of 32 patients with GBM who had MGMT status measured. Matching pre-operative MRI data were used to calculate the ADC within contrast enhancing regions of tumour. The relationship between ADC and MGMT was examined using two published ADC methods. A strong trend between a measure of ‘minimum ADC’ and methylation status was seen. An elevated minimum ADC was more likely in the methylated compared to the unmethylated MGMT group (U = 56, P = 0.0561). In contrast, utilising a two-mixture model histogram approach, a significant reduction in mean measure of the ‘low ADC’ component within the histogram was associated with an MGMT promoter methylation subtype (P < 0.0246). This study shows that within the same patient cohort, the method selected to analyse ADC measures has a significant bearing on the use of that metric as a surrogate marker of MGMT status. Thus for dMRI data to be clinically useful, consistent methods of data analysis need to be established prior to establishing any relationship with genetic or epigenetic profiling

Influence of promoter/enhancer region haplotypes on MGMT transcriptional regulation: a potential biomarker for human sensitivity to alkylating agents.

Science.gov (United States)

Xu, Meixiang; Nekhayeva, Ilona; Cross, Courtney E; Rondelli, Catherine M; Wickliffe, Jeffrey K; Abdel-Rahman, Sherif Z

2014-03-01

The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and their functional/biological significance are currently unknown. We hypothesized that MGMT P/E haplotypes, rather than individual SNPs, alter MGMT transcription and can thus alter human sensitivity to alkylating agents. To identify the haplotype structure encompassing the MGMT P/E region SNPs, we sequenced 104 DNA samples from healthy individuals and inferred the haplotypes using the data generated. We identified eight SNPs in this region, namely T7C (rs180989103), T135G (rs1711646), G290A (rs61859810), C485A (rs1625649), C575A (rs113813075), G666A (rs34180180), C777A (rs34138162) and C1099T (rs16906252). Phylogenetics and Sequence Evolution analysis predicted 21 potential haplotypes that encompass these SNPs ranging in frequencies from 0.000048 to 0.39. Of these, 10 were identified in our study population as 20 paired haplotype combinations. To determine the functional significance of these haplotypes, luciferase reporter constructs representing these haplotypes were transfected into glioblastoma cells and their effect on MGMT promoter activity was determined. Compared with the most common (reference) haplotype 1, seven haplotypes significantly upregulated MGMT promoter activity (18-119% increase; P alkylating agents.

ECP divisional training: plan 1996

OpenAIRE

Storr, Kenneth Mick

1996-01-01

The divisional training plan is produced each year at the request of the Joint Training Board (JTB) following a recommendation in the 1991 CERN Training Plan which states that divisions should produce a plan setting out training priorities. This plan presents a review of training activities. a report on ECP progress in implementing the recommendations of the 1995 CERN training plan, a discussion of divisional training objectives, and a summary of training requests generated by the 1996 period...

Clinical Neuropathology practice news 1-2014: Pyrosequencing meets clinical and analytical performance criteria for routine testing of MGMT promoter methylation status in glioblastoma

Science.gov (United States)

Preusser, Matthias; Berghoff, Anna S.; Manzl, Claudia; Filipits, Martin; Weinhäusel, Andreas; Pulverer, Walter; Dieckmann, Karin; Widhalm, Georg; Wöhrer, Adelheid; Knosp, Engelbert; Marosi, Christine; Hainfellner, Johannes A.

2014-01-01

Testing of the MGMT promoter methylation status in glioblastoma is relevant for clinical decision making and research applications. Two recent and independent phase III therapy trials confirmed a prognostic and predictive value of the MGMT promoter methylation status in elderly glioblastoma patients. Several methods for MGMT promoter methylation testing have been proposed, but seem to be of limited test reliability. Therefore, and also due to feasibility reasons, translation of MGMT methylation testing into routine use has been protracted so far. Pyrosequencing after prior DNA bisulfite modification has emerged as a reliable, accurate, fast and easy-to-use method for MGMT promoter methylation testing in tumor tissues (including formalin-fixed and paraffin-embedded samples). We performed an intra- and inter-laboratory ring trial which demonstrates a high analytical performance of this technique. Thus, pyrosequencing-based assessment of MGMT promoter methylation status in glioblastoma meets the criteria of high analytical test performance and can be recommended for clinical application, provided that strict quality control is performed. Our article summarizes clinical indications, practical instructions and open issues for MGMT promoter methylation testing in glioblastoma using pyrosequencing. PMID:24359605

Isocitrate dehydrogenase 1 and 2 genes mutations and MGMT methylation in gliomas

Directory of Open Access Journals (Sweden)

D. V. Tabakov

2017-01-01

Full Text Available Gliomas are the most common brain tumors. It is difficult to detect them at early stages of disease and there is a few available therapies providing significant improvement in survival. Mutations of isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2 play significant role in gliomogenesis, diagnostics and selection of patient therapy. We tested the distribution of IDH1 and IDH2 mutations in gliomas of different histological types and grades of malignancy by DNA melting analysis using our protocol with a sensitivity of 5 %. The results of this assay were confirmed by conventional Sanger sequencing. IDH1/2 mutations were detected in 74 % of lower grade gliomas (II and III, World Health Organization and in 14 % of glioblastomas (IV, World Health Organization. Mutation rate in gliomas with oligodendroglioma component were significantly higher then in other glioma types (р = 0.014. The IDH1 mutations was the most common (79 % of general mutation number. IDH1/2 mutations can induce aberrant gene methylation. Detection of methylation rate of the gene encoding for O6-methylguanine-DNA-methyltransferase (MGMT, predictive biomarker for treatment of gliomas with the alkylating agents, has demonstrated a partial association with IDH1/2 mutations. In 73 % of IDH1/2-mutant tumors MGMT promoter methylation were observed. At the same time IDH1/2 mutations were not revealed in 67 % tumors with MGMT promoter methylation. These results indicate existence of another mechanism of MGMT methylation in gliomas. Our data strong support for necessity of both markers testing when patient therapy is selected.

The effects of tumor treating fields and temozolomide in MGMT expressing and non-expressing patient-derived glioblastoma cells.

Science.gov (United States)

Clark, Paul A; Gaal, Jordan T; Strebe, Joslyn K; Pasch, Cheri A; Deming, Dustin A; Kuo, John S; Robins, H Ian

2017-02-01

A recent Phase 3 study of newly diagnosed glioblastoma (GBM) demonstrated the addition of tumor treating fields (TTFields) to temozolomide (TMZ) after combined radiation/TMZ significantly increased survival and progression free survival. Preliminary data suggested benefit with both methylated and unmethylated O-6-methylguanine-DNA methyl-transferase (MGMT) promoter status. To date, however, there have been no studies to address the potential interactions of TTFields and TMZ. Thus, the effects of TTFields and TMZ were studied in vitro using patient-derived GBM stem-like cells (GSCs) including MGMT expressing (TMZ resistant: 12.1 and 22GSC) and non-MGMT expressing (TMZ sensitive: 33 and 114GSC) lines. Dose-response curves were constructed using cell proliferation and sphere-forming assays. Results demonstrated a ⩾10-fold increase in TMZ resistance of MGMT-expressing (12.1GSCs: IC 50 =160μM; 22GSCs: IC 50 =44μM) compared to MGMT non-expressing (33GSCs: IC 50 =1.5μM; 114GSCs: IC 50 =5.2μM) lines. TTFields inhibited 12.1 GSC proliferation at all tested doses (50-500kHz) with an optimal frequency of 200kHz. At 200kHz, TTFields inhibited proliferation and tumor sphere formation of both MGMT GSC subtypes at comparable levels (12.1GSC: 74±2.9% and 38±3.2%, respectively; 22GSC: 61±11% and 38±2.6%, respectively; 33GSC: 56±9.5% and 60±7.1%, respectively; 114 GSC: 79±3.5% and 41±4.3%, respectively). In combination, TTFields (200kHz) and TMZ showed an additive anti-neoplastic effect with equal efficacy for TTFields in both cell types (i.e., ± MGMT expression) with no effect on TMZ resistance. This is the first demonstration of the effects of TTFields on cancer stem cells. The expansion of such studies may have clinical implications. Copyright © 2016 Elsevier Ltd. All rights reserved.

MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells

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Lee YY

2018-04-01

Full Text Available Yi-Yen Lee,1,2,* Aliaksandr A Yarmishyn,3,4,* Mong-Lien Wang,3,4 Hsiao-Yun Chen,4,5 Shih-Hwa Chiou,3–5 Yi-Ping Yang,4,5 Chun-Fu Lin,1,2 Pin-I Huang,2,6 Yi-Wei Chen,2,6 Hsin-I Ma,7 Ming-Teh Chen1,2 1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 2Faculty of Medicine, National Yang-Ming University, 3Institute of Pharmacology, National Yang-Ming University, 4Department of Medical Research, Taipei Veterans General Hospital, 5Institute of Clinical Medicine, National Yang Ming University, 6Cancer Center, Radiation Oncology Division, Taipei Veterans General Hospital, 7Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan *These authors contributed equally to this work Background: Glioblastoma multiforme (GBM is the most malignant brain tumor, and there is no effective treatment strategy. Patients with GBM have a median overall survival of only 14.6 months. Current treatment consists of safe and maximal surgical excision, followed by concurrent chemoradiotherapy and maintenance chemotherapy. There are several obstacles that hinder the effectiveness of this aggressive treatment. Temozolomide (TMZ is an oral alkylating drug that acts through alkylating the O6 position of guanine in DNA that leads to cell death. However, the expression and enzymatic activity of the DNA repair protein MGMT limits the therapeutic benefit from treatment with TMZ. MGMT reduces the efficacy of alkylating drugs by removing the methyl or alkyl group from damaged O6-methylguanine. Expression levels of MGMT play an important role in the outcome of GBM patients. miRNAs are a group of small regulatory RNAs that control target gene expression by binding to mRNAs. miR-142-3p has been found to be an important factor in the development and maintenance of the oncogenic state. Results: In this study, we sought to investigate whether miR-142-3p can regulate MGMT gene expression in GBM cells

76 FR 3648 - NIMS Training Plan

Science.gov (United States)

2011-01-20

...] NIMS Training Plan AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice of availability... comments on the NIMS Training Plan. This plan defines National Incident Management System (NIMS) national... sustaining NIMS training. In addition to delineating responsibilities and actions, the NIMS Training Plan...

S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells

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AGM Mostofa

2018-04-01

Full Text Available Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma and other cancer cell lines. MGMT protein was shown to harbor a nearly perfect PCNA-Interacting Protein (PIP box motif. Isogenic p53-null H1299 cells were engineered to express the p21 protein by two different procedures. Reciprocal immunoprecipitation/western blotting, Far-western blotting, and confocal microscopy confirmed the specific association of MGMT with PCNA and the ability of p21 to strongly disrupt the MGMT-PCNA complexes in tumor cells. Alkylation DNA damage resulted in a greater colocalization of MGMT and PCNA proteins, particularly in HCT116 cells deficient in p21 expression. p21 expression in isogenic cell lines directly correlated with markedly higher levels of MGMT mRNA, protein, activity and greater resistance to alkylating agents. In other experiments, four glioblastoma cell lines synchronized at the G1/S phase using either double thymidine or thymidine-mimosine blocks and subsequent cycling consistently showed a loss of MGMT protein at mid- to late S-phase, irrespective of the cell line, suggesting such a downregulation is fundamental to cell cycle control. MGMT protein was also specifically degraded in extracts from S-phase cells and evidence strongly suggested the involvement of PCNA-dependent CRL4Cdt2 ubiquitin-ligase in the reaction. Overall, these data provide the first evidence for non-repair functions of MGMT in cell cycle and highlight the involvement of PCNA in MGMT downregulation, with p21 attenuating the process.

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer

NARCIS (Netherlands)

Barault, L.; Amatu, A.; Bleeker, F. E.; Moutinho, C.; Falcomatà, C.; Fiano, V.; Cassingena, A.; Siravegna, G.; Milione, M.; Cassoni, P.; de Braud, F.; Rudà, R.; Soffietti, R.; Venesio, T.; Bardelli, A.; Wesseling, P.; de Witt Hamer, P.; Pietrantonio, F.; Siena, S.; Esteller, M.; Sartore-Bianchi, A.; Di Nicolantonio, F.

2015-01-01

O(6)-methyl-guanine-methyl-transferase (MGMT) silencing by promoter methylation may identify cancer patients responding to the alkylating agents dacarbazine or temozolomide. We evaluated the prognostic and predictive value of MGMT methylation testing both in tumor and cell-free circulating DNA

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer

NARCIS (Netherlands)

Barault, L.; Amatu, A.; Bleeker, F. E.; Moutinho, C.; Falcomatà, C.; Fiano, V.; Cassingena, A.; Siravegna, G.; Milione, M.; Cassoni, P.; de Braud, F.; Rudà, R.; Soffietti, R.; Venesio, T.; Bardelli, A.; Wesseling, P.; de Witt Hamer, P.; Pietrantonio, F.; Siena, S.; Esteller, M.; Sartore-Bianchi, A.; di Nicolantonio, Federica

2015-01-01

Background: O6-methyl-guanine-methyl-transferase (MGMT) silencing by promoter methylation may identify cancer patients responding to the alkylating agents dacarbazine or temozolomide. Patients and methods: We evaluated the prognostic and predictive value of MGMT methylation testing both in tumor and

Impact of Therapy Sequence with Alkylating Agents and MGMT Status in Patients with Advanced Neuroendocrine Tumors.

Science.gov (United States)

Krug, Sebastian; Boch, Michael; Rexin, Peter; Gress, Thomas M; Michl, Patrick; Rinke, Anja

2017-05-01

Alkylating chemotherapeutics with either a streptozotocin-(STZ) or temozolomide-(TEM) backbone are routinely used in patients with progressive and unresectable pancreatic neuroendocrine tumors (PNET). In addition, dacarbazine (DTIC) was described as an alternative alkylating therapy option for PNETs. The optimal treatment sequence with alkylating compounds and a potential use of O6-methylguanine-DNA methyltransferase (MGMT) level as predictive biomarker have not yet been sufficiently elucidated. The aim of our study was the evaluation of therapy sequence with either STZ-based treatment followed by DTIC (group A) or the inverse schedule with upfront DTIC (group B) and to correlate MGMT status with clinicopathological characteristics and response to therapy. We retrospectively analyzed 28 patients with neuroendocrine tumors (NET) who were treated with STZ-based therapy and DTIC. Additionally, in a second group MGMT immunohistochemistry was performed from primary and metastatic tumor sites. For statistical evaluation Kaplan-Meier analysis, Cox regression methods and Fisher's exact test were used. There was no difference of objective response and disease control between either STZ-based therapy followed by DTIC treatment (group A) after progression or the reverse sequence (group B). Median time to progression (TTP) was estimated to be 21 months in both arms. First-line STZ-based chemotherapy was not superior to first-line DTIC treatment (16 vs. 13 months; p=0.8). MGMT status did not correlate with clinicopathological characteristics or response to therapy with these alkylating agents. Upfront chemotherapy with either STZ-based treatment or DTIC monotherapy showed similar efficacy and median TTP rates. In this study, MGMT protein expression assessed by immunohistochemistry did not play an important role as a predictive marker for alkylating agents. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients.

Science.gov (United States)

Li, Xia; Wang, Yibaina; Zhang, Zuoming; Yao, Xiaoping; Ge, Jie; Zhao, Yashuang

2013-11-01

CpG island methylation in the promoter regions of the DNA mismatch repair gene mutator L homologue 1 ( MLH1 ) and DNA repair gene O 6 -methylguanine-DNA methyltransferase ( MGMT ) genes has been shown to occur in the leukocytes of peripheral blood and colorectal tissue. However, it is unclear whether the methylation levels in the blood leukocytes and colorectal tissue are correlated. The present study analyzed and compared the levels of MGMT and MLH1 gene methylation in the leukocytes of peripheral blood and colorectal tissues obtained from patients with colorectal cancer (CRC). The methylation levels of MGMT and MLH1 were examined using methylation-sensitive high-resolution melting (MS-HRM) analysis. A total of 44 patients with CRC were selected based on the MLH1 and MGMT gene methylation levels in the leukocytes of the peripheral blood. Corresponding colorectal tumor and normal tissues were obtained from each patient and the DNA methylation levels were determined. The correlation coefficients were evaluated using Spearman's rank test. Agreement was determined by generalized κ-statistics. Spearman's rank correlation coefficients (r) for the methylation levels of the MGMT and MLH1 genes in the leukocytes of the peripheral blood and normal colorectal tissue were 0.475 and 0.362, respectively (P=0.001 and 0.016, respectively). The agreement of the MGMT and MLH1 gene methylation levels in the leukocytes of the peripheral blood and normal colorectal tissue were graded as fair and poor (κ=0.299 and 0.126, respectively). The methylation levels of MGMT and MLH1 were moderately and weakly correlated between the patient-matched leukocytes and the normal colorectal tissue, respectively. Blood-derived DNA methylation measurements may not always represent the levels of normal colorectal tissue methylation.

O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

Science.gov (United States)

Bobola, Michael S.; Alnoor, Mohammad; Chen, John Y.-S.; Kolstoe, Douglas D.; Silbergeld, Daniel L.; Rostomily, Robert C.; Blank, A.; Chamberlain, Marc C.; Silber, John R.

2014-01-01

Background CpG methylation in the O6-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tissue has not been unequivocally assessed. This information is central to developing anti-resistance therapies. Methods We examined the relationship of MGMT activity in 91 GBMs and 84 AGs with progression-free survival (PFS) following alkylator therapy and with promoter methylation status determined by methylation-specific PCR (MSP). Results Cox regression analysis revealed that GBMs with high activity had a significantly greater risk for progression in dichotomous (P ≤ 0.001) and continuous (P ≤ 0.003) models, an association observed for different alkylator regimens, including concurrent chemo-radiation with temozolomide. Analysis of MGMT promoter methylation status in 47 of the GBMs revealed that methylated tumors had significantly lower activity (P ≤ 0.005) and longer PFS (P ≤ 0.036) compared to unmethylated tumors, despite overlapping activities. PFS was also significantly greater in methylated vs. unmethylated GBMs with comparable activity (P ≤ 0.005), and among unmethylated tumors with less than median activity (P ≤ 0.026), suggesting that mechanisms in addition to MGMT promote alkylator resistance. Similar associations of MGMT activity with PFS and promoter methylation status were observed for AGs. Conclusions Our results provide strong support for the hypotheses that MGMT activity promotes alkylator resistance and reflects promoter methylation status in malignant gliomas. General significance MGMT activity is an attractive target for anti-resistance therapy regardless of methylation status. PMID:25558448

The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma.

Directory of Open Access Journals (Sweden)

Fumiharu Ohka

Full Text Available Gliomas are the most frequently occurring primary brain tumor in the central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4 have a dismal prognosis despite the use of the alkylating agent, temozolomide (TMZ, and even low grade gliomas (LGGs, WHO grade 2 eventually transform to malignant secondary GBMs. Although GBM patients benefit from promoter hypermethylation of the O(6-methylguanine-DNA methyltransferase (MGMT that is the main determinant of resistance to TMZ, recent studies suggested that MGMT promoter methylation is of prognostic as well as predictive significance for the efficacy of TMZ. Glioma-CpG island methylator phenotype (G-CIMP in the global genome was shown to be a significant predictor of improved survival in patients with GBM. Collectively, we hypothesized that MGMT promoter methylation might reflect global DNA methylation. Additionally in LGGs, the significance of MGMT promoter methylation is still undetermined. In the current study, we aimed to determine the correlation between clinical, genetic, and epigenetic profiles including LINE-1 and different cancer-related genes and the clinical outcome in newly diagnosed 57 LGG and 54 GBM patients. Here, we demonstrated that (1 IDH1/2 mutation is closely correlated with MGMT promoter methylation and 1p/19q codeletion in LGGs, (2 LINE-1 methylation levels in primary and secondary GBMs are lower than those in LGGs and normal brain tissues, (3 LINE-1 methylation is proportional to MGMT promoter methylation in gliomas, and (4 higher LINE-1 methylation is a favorable prognostic factor in primary GBMs, even compared to MGMT promoter methylation. As a global DNA methylation marker, LINE-1 may be a promising marker in gliomas.

PFP dangerous waste training plan

International Nuclear Information System (INIS)

Khojandi, J.

1996-01-01

This document establishes the minimum training requirements for the Plutonium Finishing Plant (PFP) personnel who are responsible for management of dangerous waste. The training plan outlines training requirements for handling of solid dangerous waste during generator accumulation and liquid dangerous waste during treatment and storage operations. The implementation of this training plan will ensure the PFP facility compliance with the training plan requirements of Dangerous Waste Regulation. Chapter 173-303-330. Washington Administrative Code (WAC). The requirements for such compliance is described in Section 11.0 of WHC-CM-7-5 Environmental Compliance Manual

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.

Science.gov (United States)

Ogino, Shuji; Kawasaki, Takako; Kirkner, Gregory J; Suemoto, Yuko; Meyerhardt, Jeffrey A; Fuchs, Charles S

2007-11-01

The CpG island methylator phenotype (CIMP or CIMP-high) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer. In contrast, a phenotype with less widespread promoter methylation (CIMP-low) has not been well characterised. O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and silencing have been associated with G>A mutations and microsatellite instability-low (MSI-low). To examine molecular correlates with MGMT methylation/silencing in colorectal cancer. Utilising MethyLight technology, we quantified DNA methylation in MGMT and eight other markers (a CIMP-diagnostic panel; CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) in 920 population-based colorectal cancers. Tumours with both MGMT methylation and loss were correlated positively with MSI-low (p = 0.02), CIMP-high (>or=6/8 methylated CIMP markers, p = 0.005), CIMP-low (1/8-5/8 methylated CIMP markers, p = 0.002, compared to CIMP-0 with 0/8 methylated markers), KRAS G>A mutation (p = 0.02), and inversely with 18q loss of heterozygosity (p = 0.0002). Tumours were classified into nine MSI/CIMP subtypes. Among the CIMP-low group, tumours with both MGMT methylation and loss were far more frequent in MSI-low tumours (67%, 12/18) than MSI-high tumours (5.6%, 1/18; p = 0.0003) and microsatellite stable (MSS) tumours (33%, 52/160; p = 0.008). However, no such relationship was observed among the CIMP-high or CIMP-0 groups. The relationship between MGMT methylation/silencing and MSI-low is limited to only CIMP-low tumours, supporting the suggestion that CIMP-low in colorectal cancer may be a different molecular phenotype from CIMP-high and CIMP-0. Our data support a molecular difference between MSI-low and MSS in colorectal cancer, and a possible link between CIMP-low, MSI-low, MGMT methylation/loss and KRAS mutation.

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

Science.gov (United States)

Doak, Shareen H; Brüsehafer, Katja; Dudley, Ed; Quick, Emma; Johnson, George; Newton, Russell P; Jenkins, Gareth J S

2008-12-15

The alkylating agents methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS) have non-linear dose-response curves, with a no-observed effect level (NOEL) and a lowest observed effect level (LOEL) for both gross chromosomal damage and mutagenicity. However, the biological mechanism responsible for the NOEL has yet to be identified. A strong candidate is DNA repair as it may be able to efficiently remove alkyl adducts at low doses resulting in a NOEL, but at higher doses fails to fully remove all lesions due to saturation of enzymatic activity resulting in a LOEL and subsequent linear increases in mutagenicity. We therefore assessed the transcriptional status of N-methylpurine-DNA glycoslase (MPG) and O(6)-methylguanine DNA methyltransferase (MGMT), which represent the first line of defence following exposure to alkylating agents through the respective enzymatic removal of N7-alkylG and O(6)-alkylG. The relative MPG and MGMT gene expression profiles were assessed by real-time RT-PCR following exposure to 0-2 microg/ml MMS for 1-24h. MPG expression remained fairly steady, but in contrast significant up-regulation of MGMT was observed when cells were treated with 0.5 and 1.0 microg/ml MMS for 4h (2.5- and 6.5-fold increases respectively). These doses lie within the NOEL for MMS mutagenicity (LOEL is 1.25 microg/ml), thus this boost in MGMT expression at low doses may be responsible for efficiently repairing O(6)methylG lesions and creating the non-linear response for mutations. However, as the LOEL for MMS clastogenicity is 0.85 microg/ml, O(6)-alkylG is unlikely to be responsible for the clastogenicity observed at these concentrations. Consequently, at low doses N7-methylG is possibly the predominant cause of MMS clastogenicity, while O(6)-methylG is more likely to be responsible for MMS mutagenicity, with MGMT up-regulation playing a key role in removal of O(6)-alkylG lesions before they are fixed as permanent point mutations, resulting in non-linear dose

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.

Science.gov (United States)

Felsberg, Jörg; Thon, Niklas; Eigenbrod, Sabina; Hentschel, Bettina; Sabel, Michael C; Westphal, Manfred; Schackert, Gabriele; Kreth, Friedrich Wilhelm; Pietsch, Torsten; Löffler, Markus; Weller, Michael; Reifenberger, Guido; Tonn, Jörg C

2011-08-01

Epigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methylation status and the expression of MGMT and the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 in pairs of primary and recurrent glioblastomas of 80 patients, including 64 patients treated with radiotherapy and TMZ after the first operation. Among the primary tumors, the MGMT promoter was methylated in 31 patients and unmethylated in 49 patients. In 71 patients (89%), the MGMT promoter methylation status of the primary tumor was retained at recurrence. MGMT promoter methylation, but not MGMT protein expression, was associated with longer progression-free survival, overall survival and postrecurrence survival (PRS). Moreover, PRS was increased under salvage chemotherapy. Investigation of primary and recurrent glioblastomas of 43 patients did not identify promoter methylation in any of the four MMR genes. However, recurrent glioblastomas demonstrated significantly lower MSH2, MSH6 and PMS2 protein expression as detected by immunohistochemistry. In conclusion, reduced expression of MMR proteins, but not changes in MGMT promoter methylation, is characteristic of glioblastomas recurring after the current standards of care. Copyright © 2011 UICC.

77 FR 16862 - Proposed Information Collection Request; Training, Training Plans, and Records

Science.gov (United States)

2012-03-22

...; Training, Training Plans, and Records AGENCY: Mine Safety and Health Administration, Labor. ACTION: Request... proposed extension of the information collection related to training, training plans, and records at these.... Agency: Mine Safety and Health Administration. Title: Part 46--Training, Training Plans, and Records. OMB...

DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide.

Directory of Open Access Journals (Sweden)

Amandine Etcheverry

Full Text Available Consistently reported prognostic factors for glioblastoma (GBM are age, extent of surgery, performance status, IDH1 mutational status, and MGMT promoter methylation status. We aimed to integrate biological and clinical prognostic factors into a nomogram intended to predict the survival time of an individual GBM patient treated with a standard regimen. In a previous study we showed that the methylation status of the DGKI promoter identified patients with MGMT-methylated tumors that responded poorly to the standard regimen. We further evaluated the potential prognostic value of DGKI methylation status.399 patients with newly diagnosed GBM and treated with a standard regimen were retrospectively included in this study. Survival modelling was performed on two patient populations: intention-to-treat population of all included patients (population 1 and MGMT-methylated patients (population 2. Cox proportional hazard models were fitted to identify the main prognostic factors. A nomogram was developed for population 1. The prognostic value of DGKI promoter methylation status was evaluated on population 1 and population 2.The nomogram-based stratification of the cohort identified two risk groups (high/low with significantly different median survival. We validated the prognostic value of DGKI methylation status for MGMT-methylated patients. We also demonstrated that the DGKI methylation status identified 22% of poorly responding patients in the low-risk group defined by the nomogram.Our results improve the conventional MGMT stratification of GBM patients receiving standard treatment. These results could help the interpretation of published or ongoing clinical trial outcomes and refine patient recruitment in the future.

DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide.

Science.gov (United States)

Etcheverry, Amandine; Aubry, Marc; Idbaih, Ahmed; Vauleon, Elodie; Marie, Yannick; Menei, Philippe; Boniface, Rachel; Figarella-Branger, Dominique; Karayan-Tapon, Lucie; Quillien, Veronique; Sanson, Marc; de Tayrac, Marie; Delattre, Jean-Yves; Mosser, Jean

2014-01-01

Consistently reported prognostic factors for glioblastoma (GBM) are age, extent of surgery, performance status, IDH1 mutational status, and MGMT promoter methylation status. We aimed to integrate biological and clinical prognostic factors into a nomogram intended to predict the survival time of an individual GBM patient treated with a standard regimen. In a previous study we showed that the methylation status of the DGKI promoter identified patients with MGMT-methylated tumors that responded poorly to the standard regimen. We further evaluated the potential prognostic value of DGKI methylation status. 399 patients with newly diagnosed GBM and treated with a standard regimen were retrospectively included in this study. Survival modelling was performed on two patient populations: intention-to-treat population of all included patients (population 1) and MGMT-methylated patients (population 2). Cox proportional hazard models were fitted to identify the main prognostic factors. A nomogram was developed for population 1. The prognostic value of DGKI promoter methylation status was evaluated on population 1 and population 2. The nomogram-based stratification of the cohort identified two risk groups (high/low) with significantly different median survival. We validated the prognostic value of DGKI methylation status for MGMT-methylated patients. We also demonstrated that the DGKI methylation status identified 22% of poorly responding patients in the low-risk group defined by the nomogram. Our results improve the conventional MGMT stratification of GBM patients receiving standard treatment. These results could help the interpretation of published or ongoing clinical trial outcomes and refine patient recruitment in the future.

20 CFR 628.420 - Job training plan.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Job training plan. 628.420 Section 628.420... THE JOB TRAINING PARTNERSHIP ACT Local Service Delivery System § 628.420 Job training plan. (a) The Governor shall issue instructions and schedules to assure that job training plans and plan modifications...

Double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours.

Science.gov (United States)

Burke, Elinor; Grobler, Mariana; Elderfield, Kay; Bond, Frances; Crocker, Matthew; Taylor, Rohan; Bridges, Leslie R

2013-06-10

Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA, a recognised molecular genetic technique which we applied as the gold-standard for the methylation status). Double-labelling immunohistochemistry for MGMT produced a visual separation of tumourous and non-tumourous elements on the same histological slide, making it quick and easy to determine whether tumour cell nuclei were MGMT-positive or MGMT-negative (and thereby infer the methylation status of the tumour). We found good agreement between observers (kappa 0.76) and within observer (kappa 0.84). Furthermore, double-labelling showed good specificity (80%), sensitivity (73.33%), positive predictive value (PPV, 83.33%) and negative predictive value (NPV, 68.75%) compared to MS-MLPA. Double-labelling was quicker and easier to assess than single-labelling and it outperformed quantitative computerised image analysis of MGMT single-labelling in terms of sensitivity, specificity, PPV and NPV. Double-labelling immunohistochemistry for MGMT and a cocktail of non-tumourous elements provides a "one look" method for determining whether tumour cell nuclei are MGMT-positive or MGMT-negative. This can be used to infer the methylation status of the tumour. There is good observer agreement and good specificity, sensitivity, PPV and NPV compared to a molecular gold-standard.

A Hypermethylated Phenotype Is a Better Predictor of Survival than MGMT Methylation in Anaplastic Oligodendroglial Brain Tumors: A Report from EORTC Study 26951

NARCIS (Netherlands)

Bent, M.J. van den; Gravendeel, L.A.; Gorlia, T.; Kros, J.M.; Lapre, L.; Wesseling, P.; Teepen, J.L.; Idbaih, A.; Sanson, M.; Smitt, P.A.; French, P.J.

2011-01-01

PURPOSE: The MGMT promoter methylation status has been suggested to be predictive for outcome to temozolomide chemotherapy in patients with glioblastoma (GBM). Subsequent studies indicated that MGMT promoter methylation is a prognostic marker even in patients treated with radiotherapy alone, both in

Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking

Directory of Open Access Journals (Sweden)

Guohui Sun

2016-06-01

Full Text Available DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT, which plays an important role in inducing drug resistance against alkylating agents that modify the O6 position of guanine in DNA, is an attractive target for anti-tumor chemotherapy. A series of MGMT inhibitors have been synthesized over the past decades to improve the chemotherapeutic effects of O6-alkylating agents. In the present study, we performed a three-dimensional quantitative structure activity relationship (3D-QSAR study on 97 guanine derivatives as MGMT inhibitors using comparative molecular field analysis (CoMFA and comparative molecular similarity indices analysis (CoMSIA methods. Three different alignment methods (ligand-based, DFT optimization-based and docking-based alignment were employed to develop reliable 3D-QSAR models. Statistical parameters derived from the models using the above three alignment methods showed that the ligand-based CoMFA (Qcv2 = 0.672 and Rncv2 = 0.997 and CoMSIA (Qcv2 = 0.703 and Rncv2 = 0.946 models were better than the other two alignment methods-based CoMFA and CoMSIA models. The two ligand-based models were further confirmed by an external test-set validation and a Y-randomization examination. The ligand-based CoMFA model (Qext2 = 0.691, Rpred2 = 0.738 and slope k = 0.91 was observed with acceptable external test-set validation values rather than the CoMSIA model (Qext2 = 0.307, Rpred2 = 0.4 and slope k = 0.719. Docking studies were carried out to predict the binding modes of the inhibitors with MGMT. The results indicated that the obtained binding interactions were consistent with the 3D contour maps. Overall, the combined results of the 3D-QSAR and the docking obtained in this study provide an insight into the understanding of the interactions between guanine derivatives and MGMT protein, which will assist in designing novel MGMT inhibitors with desired activity.

Double-labelling immunohistochemistry for MGMT and a “cocktail” of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours

Science.gov (United States)

2013-01-01

Background Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA, a recognised molecular genetic technique which we applied as the gold-standard for the methylation status). Results Double-labelling immunohistochemistry for MGMT produced a visual separation of tumourous and non-tumourous elements on the same histological slide, making it quick and easy to determine whether tumour cell nuclei were MGMT-positive or MGMT-negative (and thereby infer the methylation status of the tumour). We found good agreement between observers (kappa 0.76) and within observer (kappa 0.84). Furthermore, double-labelling showed good specificity (80%), sensitivity (73.33%), positive predictive value (PPV, 83.33%) and negative predictive value (NPV, 68.75%) compared to MS-MLPA. Double-labelling was quicker and easier to assess than single-labelling and it outperformed quantitative computerised image analysis of MGMT single-labelling in terms of sensitivity, specificity, PPV and NPV. Conclusions Double-labelling immunohistochemistry for MGMT and a cocktail of non-tumourous elements provides a "one look" method for determining whether tumour cell nuclei are MGMT-positive or MGMT-negative. This can be used to infer the methylation status of the tumour. There is good observer agreement and good specificity, sensitivity, PPV and NPV compared to a molecular gold-standard. PMID:24252243

Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma

International Nuclear Information System (INIS)

Santos, Juliana Carvalho; Bastos, André Uchimura; Cerutti, Janete Maria; Ribeiro, Marcelo Lima

2013-01-01

Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated with mutations in genes such as BRAF, RAS and IDH1 in colon and brain tumours. Little is known about the methylation status of MLH1 and MGMT in thyroid tumours and its association with MSI and mutational status. In a series of 96 thyroid tumours whose mutational profiles of BRAF, IDH1 and NRAS mutations and RET/PTC were previously determined, we investigated MLH1 and MGMT expression and methylation status by qPCR and methylation-specific PCR after bisulphite treatment, respectively. MSI was determined by PCR using seven standard microsatellite markers. Samples with point mutations (BRAF, IDH1 and NRAS) show a decrease in MLH1 expression when compared to negative samples. Additionally, malignant lesions show a higher MSI pattern than benign lesions. The MSI phenotype was also associated with down-regulation of MLH1. The results of this study allow us to conclude that low expression of MLH1 is associated with BRAF V600E mutations, RET/PTC rearrangements and transitions (IDH1 and NRAS) in patients with thyroid carcinoma. In addition, a significant relationship between MSI status and histological subtypes was found

Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: An immunohistochemical study

Science.gov (United States)

Giaginis, Constantinos; Michailidi, Christina; Stolakis, Vasileios; Alexandrou, Paraskevi; Tsourouflis, Gerasimos; Klijanienko, Jerzy; Delladetsima, Ioanna; Theocharis, Stamatios

2011-01-01

Summary Background DNA repair is a major defense mechanism, which contributes to the maintenance of genetic sequence, and minimizes cell death, mutation rates, replication errors, DNA damage persistence and genomic instability. Alterations in the expression levels of proteins participating in DNA repair mechanisms have been associated with several aspects of cancer biology. The present study aimed to evaluate the clinical significance of DNA repair proteins MSH2, MLH1 and MGMT in benign and malignant thyroid lesions. Material/Methods MSH2, MLH1 and MGMT protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 90 patients with benign and malignant lesions. Results The expression levels of MLH1 was significantly upregulated in cases with malignant compared to those with benign thyroid lesions (p=0.038). The expression levels of MGMT was significantly downregulated in malignant compared to benign thyroid lesions (p=0.001). Similar associations for both MLH1 and MGMT between cases with papillary carcinoma and hyperplastic nodules were also noted (p=0.014 and p=0.026, respectively). In the subgroup of malignant thyroid lesions, MSH2 downregulation was significantly associated with larger tumor size (p=0.031), while MLH1 upregulation was significantly associated with the presence of lymphatic and vascular invasion (p=0.006 and p=0.002, respectively). Conclusions Alterations in the mismatch repair proteins MSH2 and MLH1 and the direct repair protein MGMT may result from tumor development and/or progression. Further studies are recommended to draw definite conclusions on the clinical significance of DNA repair proteins in thyroid neoplasia. PMID:21358597

Differential Radiosensitizing Potential of Temozolomide in MGMT Promoter Methylated Glioblastoma Multiforme Cell Lines

International Nuclear Information System (INIS)

Nifterik, Krista A. van; Berg, Jaap van den; Stalpers, Lukas J.A.; Lafleur, M. Vincent M.; Leenstra, Sieger; Slotman, Ben J.; Hulsebos, Theo J.M.; Sminia, Peter

2007-01-01

Purpose: To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and fractionated γ-irradiation. Methods and Materials: Three genetically characterized human GBM cell lines (AMC-3046, VU-109, and VU-122) were exposed to various single (0-6 Gy) and daily fractionated doses (2 Gy per fraction) of γ-irradiation. Repeated TMZ doses were given before and concurrent with irradiation treatment. Immediately plated clonogenic cell-survival curves were determined for both the single-dose and the fractionated irradiation experiments. To establish the net effect of clonogenic cell survival and cell proliferation, growth curves were determined, expressed as the number of surviving cells. Results: All three cell lines showed MGMT promoter methylation, lacked MGMT protein expression, and were sensitive to TMZ. The isotoxic TMZ concentrations used were in a clinically feasible range of 10 μmol/L (AMC-3046), 3 μmol/L (VU-109), and 2.5 μmol/L (VU-122). Temozolomide was able to radiosensitize two cell lines (AMC 3046 and VU-122) using single-dose irradiation. A reduction in the number of surviving cells after treatment with the combination of TMZ and fractionated irradiation was seen in all three cell lines, but only AMC 3046 showed a radiosensitizing effect. Conclusions: This study on TMZ-sensitive GBM cell lines shows that TMZ can act as a radiosensitizer and is at least additive to γ-irradiation. Enhancement of the radiation response by TMZ seems to be independent of the epigenetically silenced MGMT gene

30 CFR 46.4 - Training plan implementation.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Training plan implementation. 46.4 Section 46.4..., SURFACE CLAY, COLLOIDAL PHOSPHATE, OR SURFACE LIMESTONE MINES. § 46.4 Training plan implementation. (a... accordance with the written training plan; (2) Presented by a competent person; and (3) Presented in language...

INDOT Technical Training Plan

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations : for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and E...

Planning and training in emergency preparedness

International Nuclear Information System (INIS)

Perkins, T.G.

1985-01-01

Link Simulation Systems Division of the Singer Company is combining its tactical simulation and display system with state-of-the-art decision and control technology to provide a combined operations, planning, and training (COPAT) system. This system provides for the total integration of the three primary responsibilities of emergency managers: planning and training for and decision and control of an emergency. The system is intended to be a complete operations center for emergency management personnel. In the event of a natural disaster or man-made emergency, the national, state, county, and city emergency managers require a secure and reliable operations center. The COPAT system combines the decision and control capabilities with proven simulation techniques allowing for integrated planning and training. The hardware system, software, data bases, and maps used during planning and training are the same as those used during actual emergencies

Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.

Directory of Open Access Journals (Sweden)

Arne Christians

Full Text Available Hypermethylation in the promoter region of the MGMT gene encoding the DNA repair protein O(6-methylguanine-DNA methyltransferase is among the most important prognostic factors for patients with glioblastoma and predicts response to treatment with alkylating agents like temozolomide. Hence, the MGMT status is widely determined in most clinical trials and frequently requested in routine diagnostics of glioblastoma. Since various different techniques are available for MGMT promoter methylation analysis, a generally accepted consensus as to the most suitable diagnostic method remains an unmet need. Here, we assessed methylation-specific polymerase chain reaction (MSP as a qualitative and semi-quantitative method, pyrosequencing (PSQ as a quantitative method, and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA as a semi-quantitative method in a series of 35 formalin-fixed, paraffin-embedded glioblastoma tissues derived from patients treated in a prospective clinical phase II trial that tested up-front chemoradiotherapy with dose-intensified temozolomide (UKT-05. Our goal was to determine which of these three diagnostic methods provides the most accurate prediction of progression-free survival (PFS. The MGMT promoter methylation status was assessable by each method in almost all cases (n = 33/35 for MSP; n = 35/35 for PSQ; n = 34/35 for MS-MLPA. We were able to calculate significant cut-points for the continuous methylation signals at each CpG site analysed by PSQ (range, 11.5 to 44.9% and at one CpG site assessed by MS-MLPA (3.6% indicating that a dichotomisation of continuous methylation data as a prerequisite for comparative survival analyses is feasible. Our results show that, unlike MS-MLPA, MSP and PSQ provide a significant improvement of predicting PFS compared with established clinical prognostic factors alone (likelihood ratio tests: p<0.001. Conclusively, taking into consideration prognostic value

Avaliação da expressão do gene MGMT nos tecidos normal e neoplásico de doentes com câncer colorretal

Directory of Open Access Journals (Sweden)

Adriana Teixeira Cordeiro

Full Text Available OBJETIVO: Avaliar a expressão tecidual do gene de reparo MGMT comparando a mucosa cólica normal e neoplásica em doentes com câncer colorretal. MÉTODOS: Foram estudados 44 portadores de adenocarcinoma colorretal confirmado por estudo histopatológico. Foram excluídos doentes suspeitos de pertencerem a famílias com câncer colorretal hereditário (HNPCC e PAF e os portadores de câncer do reto médio e inferior submetidos a tratamento quimioradioterápico neoadjuvante. A expressão do gene MGMT foi avaliada pela técnica da reação de polimerase em cadeia em tempo real (RT-PCR. A comparação dos resultados encontrados para expressão do gene MGMT entre tecidos normais e neoplásicos foi feita pelo teste t de Student pareado, adotando-se nível de significância de 5% (p <0,05. RESULTADOS: A expressão tecidual do gene MGMT em todos os doentes foi menor no tecido neoplásico quando comparada a do tecido normal (p=0,002. CONCLUSÃO: O gene de reparo MGMT encontra-se menos expresso no tecido neoplásico quando comparados aos tecidos normais em portadores de CCR esporádico.

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

Science.gov (United States)

Sartore-Bianchi, Andrea; Pietrantonio, Filippo; Amatu, Alessio; Milione, Massimo; Cassingena, Andrea; Ghezzi, Silvia; Caporale, Marta; Berenato, Rosa; Falcomatà, Chiara; Pellegrinelli, Alessio; Bardelli, Alberto; Nichelatti, Michele; Tosi, Federica; De Braud, Filippo; Di Nicolantonio, Federica; Barault, Ludovic; Siena, Salvatore

2017-01-01

O(6)-methylguanine-DNA-methyltransferase (MGMT) is a repair protein, and its deficiency makes tumours more susceptible to the cytotoxic effect of alkylating agents. Five clinical trials with temozolomide or dacarbazine have been performed in metastatic colorectal cancer (mCRC) with selection based on methyl-specific PCR (MSP) testing with modest results. We hypothesised that mitigated results are consequences of unspecific patient selection and that alternative methodologies for MGMT testing such as immunohistochemistry (IHC) and digital polymerase chain reaction (PCR) could enhance patient enrolment. Formalin-fixed paraffin embedded archival tumour tissue samples from four phase II studies of temozolomide or dacarbazine in MGMT MSP-positive mCRCs were analysed by IHC for MGMT protein expression and by methyl-BEAMing (MB) for percentage of promoter methylation. Pooled data were then retrospectively analysed according to objective response rate, progression-free survival (PFS) and overall survival (OS). One hundred and five patients were included in the study. Twelve had achieved partial response (PR) (11.4%), 24 stable disease (SD; 22.9%) and 69 progressive disease (PD; 65.7%). Patients with PR/SD had lower IHC scores and higher MB levels than those with PD. MGMT expression by IHC was negatively and MB levels positively associated with PFS (p alkylating agents. Their combination could enhance patient selection in this setting. Copyright © 2016 Elsevier Ltd. All rights reserved.

SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer

Science.gov (United States)

Kuroiwa-Trzmielina, Joice; Wang, Fan; Rapkins, Robert W.; Ward, Robyn L.; Buchanan, Daniel D.; Win, Aung Ko; Clendenning, Mark; Rosty, Christophe; Southey, Melissa C.; Winship, Ingrid M.; Hopper, John L.; Jenkins, Mark A.; Olivier, Jake; Hawkins, Nicholas J.; Hitchins, Megan P.

2016-01-01

Purpose Methylation of the MGMT promoter is the major cause of O6-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter-enhancer SNP rs16906252C>T. We sought evidence for an association between the rs16906252C>T genotype and increased risk of developing a subtype of colorectal cancer (CRC) featuring MGMT methylation, mediated by genotype-dependent epigenetic silencing within normal tissues. Experimental design By applying a molecular pathological epidemiology case-control study design, associations between rs16906252C>T and risk for CRC overall, and CRC stratified by MGMT methylation status, were estimated using multinomial logistic regression in two independent retrospective series of CRC cases and controls. The test sample comprised 1054 CRC cases and 451 controls from Sydney, Australia. The validation sample comprised 612 CRC cases and 245 controls from the Australasian Colon Cancer Family Registry (ACCFR). To determine if rs16906252C>T was linked to a constitutively altered epigenetic state, quantitative allelic expression and methylation analyses were performed in normal tissues. Results An association between rs16906252C>T and increased risk of developing MGMT-methylated CRC in the Sydney sample was observed (OR 3.3; 95%CI=2.0–5.3; PT represents an expression and methylation quantitative trait locus. Conclusions We provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated CRC, likely mediated by constitutive epigenetic repression of the T allele. PMID:27267851

The planning of training process in triathlon

Directory of Open Access Journals (Sweden)

Volodymyr Vodlozerov

2016-04-01

Full Text Available Purpose: is the working out of base variant of training process as the base for planning of individual training of triathlete. Material & Methods: studying and generalization of special literature of basis training process for endurance in cyclic kinds of sports, the analysis of training of famous triathletes to competitions. Results: mane stages of training process formation in triathlon and features of distribution of sportsman’s training load in depending on period of training were considered. Conclusions: comprehensive planning of training process in different kinds of triathlon is lying down in basis of improving of competition form of triathlete.

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status.

Science.gov (United States)

Bady, Pierre; Sciuscio, Davide; Diserens, Annie-Claire; Bloch, Jocelyne; van den Bent, Martin J; Marosi, Christine; Dietrich, Pierre-Yves; Weller, Michael; Mariani, Luigi; Heppner, Frank L; Mcdonald, David R; Lacombe, Denis; Stupp, Roger; Delorenzi, Mauro; Hegi, Monika E

2012-10-01

The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and epigenetic features of this intriguingly distinct behavior requires accurate MGMT classification to assess high throughput molecular databases. Promoter methylation-mediated gene silencing is strongly dependent on the location of the methylated CpGs, complicating classification. Using the HumanMethylation450 (HM-450K) BeadChip interrogating 176 CpGs annotated for the MGMT gene, with 14 located in the promoter, two distinct regions in the CpG island of the promoter were identified with high importance for gene silencing and outcome prediction. A logistic regression model (MGMT-STP27) comprising probes cg12434587 [corrected] and cg12981137 provided good classification properties and prognostic value (kappa = 0.85; log-rank p CIMP) positive tumors was found in glioblastomas from The Cancer Genome Atlas than in low grade and anaplastic glioma cohorts, while in CIMP-negative gliomas MGMT was classified as methylated in approximately 50 % regardless of tumor grade. The proposed MGMT-STP27 prediction model allows mining of datasets derived on the HM-450K or HM-27K BeadChip to explore effects of distinct epigenetic context of MGMT methylation suspected to modulate treatment resistance in different tumor types.

75 FR 79030 - Proposed Extension of Existing Information Collection; Training Plans and Records of Training

Science.gov (United States)

2010-12-17

... Extension of Existing Information Collection; Training Plans and Records of Training AGENCY: Mine Safety and... extension of the information collection for Training Plans and Records of Training, 30 CFR 48.3, 48.9, 48.23... require training plans for underground and surface mines, respectively. The standards are intended to...

Double-labelling immunohistochemistry for MGMT and a “cocktail” of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours

OpenAIRE

Burke, Elinor; Grobler, Mariana; Elderfield, Kay; Bond, Frances; Crocker, Matthew; Taylor, Rohan; Bridges, Leslie R

2013-01-01

Background Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT an...

Train turn restrictions and line plan performance

DEFF Research Database (Denmark)

Burggraeve, Sofie; Bull, Simon Henry; Lusby, Richard Martin

In this paper we study the impact of the `turn conditions' in end stations on the performance of a line plan. If trains have to turn on their platform in an end station, the yoccupy the platform for several minutes. A more preferred option, from a timetabling point of view, would be that a train...... in a exible and large enough shunt. Starting from a given line plan, we compare two timetables, one where trains have to turn on their platform and one where trains can turn in a shunt. We evaluate the impact on the performance of the line plan by its feasibility for timetabling,the minimum overall buffer...... disappears from the platform in its end station after dwelling and only appears again when departing for a subsequent trip. In this case, the train will not interfere with other trains that dwell on the platform during the time between these events. However, this option is only possible if the train can stay...

Computer-aided waste management strategic planning and analysis

International Nuclear Information System (INIS)

Avci, H.I.; Kotek, T.J.; Koebnick, B.L.

1995-01-01

A computational model called WASTE-MGMT has been developed to assist in the evaluation of alternative waste management approaches in a complex setting involving multiple sites, waste streams, and processing options. The model provides the quantities and characteristics of wastes processed at any facility or shipped between any two sites as well as environmental emissions at any facility within the waste management system. The model input is defined by three types of fundamental waste management data: (1) waste inventories and characteristics at the point of generation; (2) treatment, storage, and disposal facility characteristics; and (3) definitions of alternative management approaches. The model has been successfully used in the preparation of the US Department of Energy (DOE) Environmental Management Programmatic.Environmental Impact Statement (EM PEIS). Certain improvements are either being implemented or planned that would extend the usefulness and applicability of the WASTE-MGMT model beyond the EM PEIS and info the. strategic planning for management of wastes under the responsibility of DOE or other agencies

Payload Crew Training Complex (PCTC) utilization and training plan

Science.gov (United States)

Self, M. R.

1980-01-01

The physical facilities that comprise the payload crew training complex (PCTC) are described including the host simulator; experiment simulators; Spacelab aft flight deck, experiment pallet, and experiment rack mockups; the simulation director's console; payload operations control center; classrooms; and supporting soft- and hardware. The parameters of a training philosophy for payload crew training at the PCTC are established. Finally the development of the training plan is addressed including discussions of preassessment, and evaluation options.

Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population.

Directory of Open Access Journals (Sweden)

Rupal Sinha

Full Text Available Colorectal cancer (CRC development involves underlying modifications at genetic/epigenetic level. This study evaluated the role of Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation together/independently in sporadic CRC in Indian population and correlation with clinicopathological variables of the disease.One hundred and twenty four consecutive surgically resected tissues (62 tumor and equal number of normal adjacent controls of primary sporadic CRC were included and patient details including demographic characteristics, lifestyle/food or drinking habits, clinical and histopathological profiles were recorded. Polymerase chain reaction - Restriction fragment length polymorphism and direct sequencing for Kras gene mutation and Methylation Specific-PCR for RASSF1A, FHIT and MGMT genes was performed.Kras gene mutation at codon 12 & 13 and methylated RASSF1A, FHIT and MGMT gene was observed in 47%, 19%, 47%, 37% and 47% cases, respectively. Alcohol intake and smoking were significantly associated with presence of Kras mutation (codon 12 and MGMT methylation (p-value <0.049. Tumor stage and metastasis correlated with presence of mutant Kras codon 12 (p-values 0.018, 0.044 and methylated RASSF1A (p-values 0.034, 0.044, FHIT (p-values 0.001, 0.047 and MGMT (p-values 0.018, 0.044 genes. Combinatorial effect of gene mutation/methylation was also observed (p-value <0.025. Overall, tumor stage 3, moderately differentiated tumors, presence of lymphatic invasion and absence of metastasis was more frequently observed in tumors with mutated Kras and/or methylated RASSF1A, FHIT and MGMT genes.Synergistic interrelationship between these genes in sporadic CRC may be used as diagnostic/prognostic markers in assessing the overall pathological status of CRC.

30 CFR 77.107-1 - Plans for training programs.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Plans for training programs. 77.107-1 Section... COAL MINES Qualified and Certified Persons § 77.107-1 Plans for training programs. Each operator must..., a program or plan setting forth what, when, how, and where the operator will train and retrain...

Training and plant performance: a strategic planning partnership

International Nuclear Information System (INIS)

Coe, R.P.

1987-01-01

The nuclear industry as a whole, and specifically GPU Nuclear, is refocusing its attention on performance indicators. This standardized assessment of plant operational performance surfaces numerous examples of how performance-based training positively impacts plant performance. Numerous examples of high dollar savings range from scram reduction programs to reducing personnel rem exposures. The deeper the authors look the more they find that training is making a difference. The question now is, how long can they continue to afford the ever increasing demands of the pursuit of excellence. Early in 1985, the Training and Education Department at GPU Nuclear proactively began its strategic planning effort in order to address the increasing industry initiatives while facing flat or reduced commitments of resources. The Training Strategic Plan addresses detailed plans for each of the following areas: curriculum planning; program development; training and education organizational structure; training and education administrative procedures; training advisory structure and priority process; financial strategies. All of the above strategies are designed to assure training effectiveness. With the nuclear option under such strong public scrutiny, it is in the best interest of all of the nuclear utilities to assure the most cost effective approach to successful operation while achieving their standards of excellence

ABERRANT METHYLATION OF THE PROMOTER OF APC, CDH13 AND MGMT GENES IN COLORECTAL CANCER PATIENTS

Directory of Open Access Journals (Sweden)

O. I. Kit

2016-01-01

Full Text Available Aberrant methylation of gene promoter regions is the main epigenetic change characterizing colorectal cancer. Methylation levels of 42 CpG-sites of promoter regions of the MGMT, APC and CDH13 genes in colorectal cancer were studied in comparison with methylation levels of the adjacent normal tissue in 25 patients. Pyrosequencing showed an increase in methylation levels of promoter regions of the MGMT, APC and CDH13 genes in tumor samples by 3 to 5 times. These tumor samples were screened for activating SNP-mutations in the KRAS (40 %, NRAS (0 % and BRAF (0 % oncogenes. SNP-mutations in the KRAS gene were accompanied by hypermethylation of one or more promoters of the studied genes. Association of this epigenetic index with tumor metastasis was proved. The data on an increase in methylation of the promoter regions of oncosupressor genes can be used as sensitive prognostic markers of progression and metastasis of colorectal cancer.

30 CFR 75.161 - Plans for training programs.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Plans for training programs. 75.161 Section 75... Provision] § 75.161 Plans for training programs. Each operator must submit to the district manager, of the Coal Mine Safety and Health District in which the mine is located, a program or plan setting forth what...

INDOT Technical Training Plan : Appendix H

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix L

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix D

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix A

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix G

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix P

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix I

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix M

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix F

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix E

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix O

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix J

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix K

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix B

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix N

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

INDOT Technical Training Plan : Appendix C

Science.gov (United States)

2012-04-01

The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

45 CFR 235.62 - State plan requirements for training programs.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false State plan requirements for training programs. 235... ADMINISTRATION OF FINANCIAL ASSISTANCE PROGRAMS § 235.62 State plan requirements for training programs. A State plan under title I, IV-A, X, XIV, or XVI (AABD) of the Act must provide for a training program for...

Personality Traits and Training Initiation Process: Intention, Planning, and Action Initiation.

Science.gov (United States)

Laguna, Mariola; Purc, Ewelina

2016-01-01

The article aims at investigating the role of personality traits in relation to training initiation. Training initiation is conceptualized as a goal realization process, and explained using goal theories. There are three stages of the process analyzed: intention to undertake training, plan formulation, and actual training undertaking. Two studies tested the relationships between five personality traits, defined according to the five factor model, and the stages of the goal realization process. In Study 1, which explains training intention and training plans' formulation, 155 employees participated. In Study 2, which was time-lagged with two measurement points, and which explains intention, plans, and training actions undertaken, the data from 176 employees was collected at 3 month intervals. The results of these studies show that personality traits, mainly openness to experience, predict the training initiation process to some degree: intention, plans, and actual action initiation. The findings allow us to provide recommendations for practitioners responsible for human resource development. The assessment of openness to experience in employees helps predict their motivation to participate in training activities. To increase training motivation it is vital to strengthen intentions to undertake training, and to encourage training action planning.

Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

Science.gov (United States)

Weller, Michael; Stupp, Roger; Hegi, Monika E.; van den Bent, Martin; Tonn, Joerg C.; Sanson, Marc; Wick, Wolfgang; Reifenberger, Guido

2012-01-01

Histological subtyping and grading by malignancy are the cornerstones of the World Health Organization (WHO) classification of tumors of the central nervous system. They shall provide clinicians with guidance as to the course of disease to be expected and the choices of treatment to be made. Nonetheless, patients with histologically identical tumors may have very different outcomes, notably in patients with astrocytic and oligodendroglial gliomas of WHO grades II and III. In gliomas of adulthood, 3 molecular markers have undergone extensive studies in recent years: 1p/19q chromosomal codeletion, O6-methylguanine methyltransferase (MGMT) promoter methylation, and mutations of isocitrate dehydrogenase (IDH) 1 and 2. However, the assessment of these molecular markers has so far not been implemented in clinical routine because of the lack of therapeutic implications. In fact, these markers were considered to be prognostic irrespective of whether patients were receiving radiotherapy (RT), chemotherapy, or both (1p/19q, IDH1/2), or of limited value because testing is too complex and no chemotherapy alternative to temozolomide was available (MGMT). In 2012, this situation has changed: long-term follow-up of the Radiation Therapy Oncology Group 9402 and European Organisation for Research and Treatment of Cancer 26951 trials demonstrated an overall survival benefit from the addition to RT of chemotherapy with procarbazine/CCNU/vincristine confined to patients with anaplastic oligodendroglial tumors with (vs without) 1p/19q codeletion. Furthermore, in elderly glioblastoma patients, the NOA-08 and the Nordic trial of RT alone versus temozolomide alone demonstrated a profound impact of MGMT promoter methylation on outcome by therapy and thus established MGMT as a predictive biomarker in this patient population. These recent results call for the routine implementation of 1p/19q and MGMT testing at least in subpopulations of malignant glioma patients and represent an encouraging

190-C Facility <90 Day Storage Pad training plan

International Nuclear Information System (INIS)

Little, N.C.

1996-12-01

This is the Environmental Restoration Contractor (ERC) team training plan for the 190-C Facility <90 Day Storage Pad of Hazardous Waste. It is intended to meet the requirements of Washington Administrative Code (WAC) 173-303-330 and the Hanford Dangerous Waste Permit. Training unrelated to compliance with WAC 173-303-330 is not addressed in this training plan. WAC 173-303-330(1)(d)(ii, v, vi) requires that personnel be familiarized, where applicable, with waste feed cut-off systems, response to ground-water contamination incidents, and shutdown of operations. These are not applicable to 190-C Facility <90 Day Storage Pad, and are therefore not covered in this training plan

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

NARCIS (Netherlands)

P. Bady (Pierre); D. Sciuscio (Davide); A.C. Diserens; J. Bloch (Jocelyne); M.J. van den Bent (Martin); C. Marosi (Christine); P-Y. Dietrich (Pierre Yves); M. Weller (Michael); L. Mariani (Luigi); F.L. Heppner (Frank ); D.R. Mcdonald (David ); D. Lacombe (Denis); R. Stupp (Roger); M. Delorenzi (Mauro); M.E. Hegi (Monika)

2012-01-01

textabstractThe methylation status of the O6-methylguanine- DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of

Self-guided training for deep brain stimulation planning using objective assessment.

Science.gov (United States)

Holden, Matthew S; Zhao, Yulong; Haegelen, Claire; Essert, Caroline; Fernandez-Vidal, Sara; Bardinet, Eric; Ungi, Tamas; Fichtinger, Gabor; Jannin, Pierre

2018-04-04

Deep brain stimulation (DBS) is an increasingly common treatment for neurodegenerative diseases. Neurosurgeons must have thorough procedural, anatomical, and functional knowledge to plan electrode trajectories and thus ensure treatment efficacy and patient safety. Developing this knowledge requires extensive training. We propose a training approach with objective assessment of neurosurgeon proficiency in DBS planning. To assess proficiency, we propose analyzing both the viability of the planned trajectory and the manner in which the operator arrived at the trajectory. To improve understanding, we suggest a self-guided training course for DBS planning using real-time feedback. To validate the proposed measures of proficiency and training course, two experts and six novices followed the training course, and we monitored their proficiency measures throughout. At baseline, experts planned higher quality trajectories and did so more efficiently. As novices progressed through the training course, their proficiency measures increased significantly, trending toward expert measures. We developed and validated measures which reliably discriminate proficiency levels. These measures are integrated into a training course, which quantitatively improves trainee performance. The proposed training course can be used to improve trainees' proficiency, and the quantitative measures allow trainees' progress to be monitored.

Strategic planning approach to nuclear training

International Nuclear Information System (INIS)

Mills, R.J.

1985-01-01

Detroit Edison Company's Nuclear Training group used an organizational planning process that yielded significant results in 1984. At the heart of the process was a concept called the Driving Force which served as the basis for the development of goals, objectives, and action plants. A key ingredient of the success of the planning process was the total, voluntary participation by all members of the organization

PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma

Science.gov (United States)

Sharpe, Martyn A.; Raghavan, Sudhir; Baskin, David S.

2018-01-01

Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. In addition to elevation of O6-methylguanine DNA methyltransferase (MGMT), down-regulation of three DNA repair pathways; canonical mismatch repair (MMR), Non-Homologous End-Joining (NHEJ), and Homologous Recombination (HR) are correlated with poor patient outcome. We have designed and tested both in vitro and in vivo, a monoamine oxidase B (MAOB) specific prodrug, PAM-OBG, that is converted by glioma MAOB into the MGMT inhibitor O6-benzylguanine (O6BG) and the DNA crosslinking agent acrolein. In cultured glioma cells, we show that PAM-OBG is converted to O6BG, inhibiting MGMT and sensitizing cells to DNA alkylating agents such as BCNU, CCNU, and Temozolomide (TMZ). In addition, we demonstrate that the acrolein generated is highly toxic in glioma treated with an inhibitor of Nucleotide Excision Repair (NER). In mouse intracranial models of primary human glioma, we show that PAM-OBG increases survival of mice treated with either BCNU or CCNU by a factor of six and that in a chemoradiation model utilizing six rounds of TMZ/2Gy radiation, pre-treatment with PAM-OBG more than doubled survival time. PMID:29844863

Developing a vision and strategic action plan for future community-based residency training.

Science.gov (United States)

Skelton, Jann B; Owen, James A

2016-01-01

The Community Pharmacy Residency Program (CPRP) Planning Committee convened to develop a vision and a strategic action plan for the advancement of community pharmacy residency training. Aligned with the profession's efforts to achieve provider status and expand access to care, the Future Vision and Action Plan for Community-based Residency Training will provide guidance, direction, and a strategic action plan for community-based residency training to ensure that the future needs of community-based pharmacist practitioners are met. National thought leaders, selected because of their leadership in pharmacy practice, academia, and residency training, served on the planning committee. The committee conducted a series of conference calls and an in-person strategic planning meeting held on January 13-14, 2015. Outcomes from the discussions were supplemented with related information from the literature. Results of a survey of CPRP directors and preceptors also informed the planning process. The vision and strategic action plan for community-based residency training is intended to advance training to meet the emerging needs of patients in communities that are served by the pharmacy profession. The group anticipated the advanced skills required of pharmacists serving as community-based pharmacist practitioners and the likely education, training and competencies required by future residency graduates in order to deliver these services. The vision reflects a transformation of community residency training, from CPRPs to community-based residency training, and embodies the concept that residency training should be primarily focused on training the individual pharmacist practitioner based on the needs of patients served within the community, and not on the physical location where pharmacy services are provided. The development of a vision statement, core values statements, and strategic action plan will provide support, guidance, and direction to the profession of pharmacy to

POSTER FOR NRMRL QUALITY MANAGEMENT PLAN (QMP) TRAINING COURSE

Science.gov (United States)

NRMRL QMP Training CourseContact: Lauren Drees, NRMRL/STD (drees.lauren@epa.gov) NRMRL has developed a computer-based course to train personnel in the requirements of the NRMRL Quality Management Plan (QMP). This training course was developed using Trainersoft s...

Training Planning and Working Memory in Third Graders

Science.gov (United States)

Goldin, Andrea Paula; Segretin, Maria Soledad; Hermida, Maria Julia; Paz, Luciano; Lipina, Sebastian Javier; Sigman, Mariano

2013-01-01

Working memory and planning are fundamental cognitive skills supporting fluid reasoning. We show that 2 games that train working memory and planning skills in school-aged children promote transfer to 2 different tasks: an attentional test and a fluid reasoning test. We also show long-term improvement of planning and memory capacities in…

Waste Encapsulation and Storage Facility (WESF) Dangerous Waste Training Plan (DWTP)

International Nuclear Information System (INIS)

SIMMONS, F.M.

2000-01-01

This Waste Encapsulation Storage Facility (WESF) Dangerous Waste Training Plan (DWTP) applies to personnel who perform work at, or in support of WESF. The plan, along with the names of personnel, may be given to a regulatory agency inspector upon request. General workers, subcontractors, or visiting personnel who have not been trained in the management of dangerous wastes must be accompanied by an individual who meets the requirements of this training plan. Dangerous waste management includes handling, treatment, storage, and/or disposal of dangerous and/or mixed waste. Dangerous waste management units covered by this plan include: less-than-90-day accumulation area(s); pool cells 1-8 and 12 storage units; and process cells A-G storage units. This training plan describes general requirements, worker categories, and provides course descriptions for operation of the WESF permitted miscellaneous storage units and the Less-than-90-Day Accumulation Areas

Screening_mgmt: a Python module for managing screening data.

Science.gov (United States)

Helfenstein, Andreas; Tammela, Päivi

2015-02-01

High-throughput screening is an established technique in drug discovery and, as such, has also found its way into academia. High-throughput screening generates a considerable amount of data, which is why specific software is used for its analysis and management. The commercially available software packages are often beyond the financial limits of small-scale academic laboratories and, furthermore, lack the flexibility to fulfill certain user-specific requirements. We have developed a Python module, screening_mgmt, which is a lightweight tool for flexible data retrieval, analysis, and storage for different screening assays in one central database. The module reads custom-made analysis scripts and plotting instructions, and it offers a graphical user interface to import, modify, and display the data in a uniform manner. During the test phase, we used this module for the management of 10,000 data points of various origins. It has provided a practical, user-friendly tool for sharing and exchanging information between researchers. © 2014 Society for Laboratory Automation and Screening.

Review of Current Aircrew Coordination Training Program and Master Plan for Program Enhancement: Aircrew Coordination Training Master Plan

National Research Council Canada - National Science Library

Grubb, G

2001-01-01

...) program to develop a master plan of continuous improvement. Research source materials included policies, training courseware, evaluation guides, research papers and reports, and assessment summaries of operational trend data...

[The specialty program as a training tool: an individual training plan for each resident].

Science.gov (United States)

Rodríguez González, R; Capilla Cabezuelo, E

2010-01-01

The official training program for the specialty "Diagnostic Imaging" establishes minimum learning objectives that must be fulfilled. Each accredited teaching unit is responsible for designing and carrying out a curriculum to ensure that these objectives are met, and this approach permits a degree of flexibility. Various aspects must be considered in the individual training plans for each resident: the rotation scheme according to the way the department is organized, plans for recovering missed material or reinforcing weak points, optional rotations, increasing degrees of responsibility as skills are acquired during training, and accommodating special needs of handicapped persons. Nevertheless, the individual plan must be fitted to the established curriculum and guarantee that the content of the official program is covered and that the objectives stipulated therein are met. Furthermore, the methods of teaching must be adapted to the individual characteristics of the residents, and this is the most important aspect of the individualization of training. To this end, it is fundamental for residents to take on an active role in their training, guided by their tutor and with the participation of all the radiologists in the department including the other residents, all of whom should act as teachers. Copyright © 2010 SERAM. Published by Elsevier Espana. All rights reserved.

Intelligent control of a planning system for astronaut training.

Science.gov (United States)

Ortiz, J; Chen, G

1999-07-01

This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconstrained environment. Formulating the planning problem in the domain of discrete-event systems under a unified framework such that it can be modeled, designed, and analyzed as a control system will provide a self-contained theory for such planning systems. This will also provide a means to certify various planning systems for operations in the dynamical and complex environments in space. The work presented here completes the design, development, and analysis of an intricate, large-scale, and representative mathematical formulation for intelligent control of a real planning system for Space Station crew training. This planning system has been tested and used at NASA-Johnson Space Center.

From Training to Learning in Enterprise Resource Planning Systems

Science.gov (United States)

Kerr, Don; Murray, Peter A.; Burgess, Kevin

2012-01-01

The information systems' literature outlines how training is a critical factor to successful Enterprise Resource Planning (ERP) implementations. Yet, types of training are not discussed in the literature and there is little indication if existing training is effective and whether relevant contextual factors have been considered. Without…

Planning a sports training program using Adaptive Particle Swarm Optimization with emphasis on physiological constraints.

Science.gov (United States)

Kumyaito, Nattapon; Yupapin, Preecha; Tamee, Kreangsak

2018-01-08

An effective training plan is an important factor in sports training to enhance athletic performance. A poorly considered training plan may result in injury to the athlete, and overtraining. Good training plans normally require expert input, which may have a cost too great for many athletes, particularly amateur athletes. The objectives of this research were to create a practical cycling training plan that substantially improves athletic performance while satisfying essential physiological constraints. Adaptive Particle Swarm Optimization using ɛ-constraint methods were used to formulate such a plan and simulate the likely performance outcomes. The physiological constraints considered in this study were monotony, chronic training load ramp rate and daily training impulse. A comparison of results from our simulations against a training plan from British Cycling, which we used as our standard, showed that our training plan outperformed the benchmark in terms of both athletic performance and satisfying all physiological constraints.

33 CFR Appendix D to Part 154 - Training Elements for Oil Spill Response Plans

Science.gov (United States)

2010-07-01

... Appendix D to Part 154—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan dealing with training is one of the key elements of a response plan. This concept is clearly expressed by... that the plans often do not provide sufficient information in the training section of the plan for...

A High-Speed Train Operation Plan Inspection Simulation Model

Directory of Open Access Journals (Sweden)

Yang Rui

2018-01-01

Full Text Available We developed a train operation simulation tool to inspect a train operation plan. In applying an improved Petri Net, the train was regarded as a token, and the line and station were regarded as places, respectively, in accordance with the high-speed train operation characteristics and network function. Location change and running information transfer of the high-speed train were realized by customizing a variety of transitions. The model was built based on the concept of component combination, considering the random disturbance in the process of train running. The simulation framework can be generated quickly and the system operation can be completed according to the different test requirements and the required network data. We tested the simulation tool when used for the real-world Wuhan to Guangzhou high-speed line. The results showed that the proposed model can be developed, the simulation results basically coincide with the objective reality, and it can not only test the feasibility of the high-speed train operation plan, but also be used as a support model to develop the simulation platform with more capabilities.

Planning of the amount of trains needed for transportation by rail

Directory of Open Access Journals (Sweden)

J. Jonaitis

2007-06-01

Full Text Available The article analyses the importance of planning process of rail transportation. Railway planning problems are presented in this paper. Planning the railways for years, months, weeks or days ahead leads to substantially different problems; in this regard railway planning problems can be strategic, tactical, operational and short-term. Another way to classify railway planning problems is based on their target: they concern the timetable, the rolling stock and the crew. Planning the structure and volume of the rolling stock is a key factor in achieving maximum efficiency of transportation by rail as well as forecasting the demand for these transport facilities. The demand for trains is a time-dependant variable which in each case should be determined by two main approaches. The first method allows us to determine quantitative parameters of rolling stock (i.e. kilometers logged, efficiency, turnover, etc.. The second is based on specially developed mathematical models relying on qualitative characteristics such as relative expenses, efficiency of the particular train, relative expenditure of resources, cost of the trains, etc. Planning the volume of the rolling stock the determination of optimal service life of the trains plays an important role. The calculations involve repair costs, number of overhauls, current expenses and operational characteristics.

''Training plan optimized design'' methodology application to IBERDROLA - Power generation

International Nuclear Information System (INIS)

Gil, S.; Mendizabal, J.L.

1996-01-01

The trend in both Europe and the United States, towards the understanding that no training plan may be considered suitable if not backed by the results of application of the S.A.T. (Systematic Approach to Training) methodology, led TECNATOM, S.A. to apply thy methodology through development of an application specific to the conditions of the Spanish working system. The requirement that design of the training be coherent with the realities of the working environment is met by systematic application of the SAT methodology as part of the work analysis and job-based task analysis processes, this serving as a basis for design of the training plans

Contract Training Services Strategic Business Plan.

Science.gov (United States)

Sir Sandford Fleming Coll., Peterborough (Ontario).

Recommending organizational structures and strategies to achieve growth in contract training services (CTS) at Ontario's (Canada) Fleming College, this report reviews external conditions and proposes effective college responses. Following an overview of results and a recommended organizational chart, the planning process is reviewed and a…

Training hospital managers for strategic planning and management: a prospective study.

Science.gov (United States)

Terzic-Supic, Zorica; Bjegovic-Mikanovic, Vesna; Vukovic, Dejana; Santric-Milicevic, Milena; Marinkovic, Jelena; Vasic, Vladimir; Laaser, Ulrich

2015-02-26

Training is the systematic acquisition of skills, rules, concepts, or attitudes and is one of the most important components in any organization's strategy. There is increasing demand for formal and informal training programs especially for physicians in leadership positions. This study determined the learning outcomes after a specific training program for hospital management teams. The study was conducted during 2006 and 2007 at the Centre School of Public Health and Management, Faculty of Medicine, University of Belgrade and included 107 participants involved in the management in 20 Serbian general hospitals. The management teams were multidisciplinary, consisting of five members on average: the director of the general hospital, the deputy directors, the head nurse, and the chiefs of support services. The managers attended a training program, which comprised four modules addressing specific topics. Three reviewers independently evaluated the level of management skills at the beginning and 12 months after the training program. Principal component analysis and subsequent stepwise multiple linear regression analysis were performed to determine predictors of learning outcomes. The quality of the SWOT (strengths, weaknesses, opportunities and threats) analyses performed by the trainees improved with differences between 0.35 and 0.49 on a Likert scale (p strategic planning. Following the training program, the external environment, strategic positioning, and quality of care were predictors of learning outcomes. The four regression models used showed that the training program had positive effects (p Strategic Plan comprising the hospital mission, vision, strategic objectives, and action plan. This study provided evidence that training for strategic planning and management enhanced the strategic decision-making of hospital management teams, which is a requirement for hospitals in an increasingly competitive, complex and challenging context. For the first time, half of

River Protection Project (RPP) Dangerous Waste Training Plan

Energy Technology Data Exchange (ETDEWEB)

POHTO, R.E.

2000-03-09

This supporting document contains the training plan for dangerous waste management at River Protection Project TSD Units. This document outlines the dangerous waste training program developed and implemented for all Treatment, Storage, and Disposal (TSD) Units operated by River Protection Project (RPP) in the Hanford 200 East, 200 West and 600 Areas and the <90 Day Accumulation Area at 209E. Operating TSD Units managed by RPP are: the Double-Shell Tank (DST) System, 204-AR Waste Unloading Facility, Grout, and the Single-Shell Tank (SST) System. The program is designed in compliance with the requirements of Washington Administrative Code (WAC) 173-303-330 and Title 40 Code of Federal Regulations (CFR) 265.16 for the development of a written dangerous waste training program and the Hanford Facility Permit. Training requirements were determined by an assessment of employee duties and responsibilities. The RPP training program is designed to prepare employees to operate and maintain the Tank Farms in a safe, effective, efficient, and environmentally sound manner. In addition to preparing employees to operate and maintain the Tank Farms under normal conditions, the training program ensures that employees are prepared to respond in a prompt and effective manner should abnormal or emergency conditions occur. Emergency response training is consistent with emergency responses outlined in the following Building Emergency Plans: HNF-IP-0263-TF and HNF-=IP-0263-209E.

River Protection Project (RPP) Dangerous Waste Training Plan

International Nuclear Information System (INIS)

POHTO, R.E.

2000-01-01

This supporting document contains the training plan for dangerous waste management at River Protection Project TSD Units. This document outlines the dangerous waste training program developed and implemented for all Treatment, Storage, and Disposal (TSD) Units operated by River Protection Project (RPP) in the Hanford 200 East, 200 West and 600 Areas and the <90 Day Accumulation Area at 209E. Operating TSD Units managed by RPP are: the Double-Shell Tank (DST) System, 204-AR Waste Unloading Facility, Grout, and the Single-Shell Tank (SST) System. The program is designed in compliance with the requirements of Washington Administrative Code (WAC) 173-303-330 and Title 40 Code of Federal Regulations (CFR) 265.16 for the development of a written dangerous waste training program and the Hanford Facility Permit. Training requirements were determined by an assessment of employee duties and responsibilities. The RPP training program is designed to prepare employees to operate and maintain the Tank Farms in a safe, effective, efficient, and environmentally sound manner. In addition to preparing employees to operate and maintain the Tank Farms under normal conditions, the training program ensures that employees are prepared to respond in a prompt and effective manner should abnormal or emergency conditions occur. Emergency response training is consistent with emergency responses outlined in the following Building Emergency Plans: HNF-IP-0263-TF and HNF-=IP-0263-209E

33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

Science.gov (United States)

2010-07-01

.... 155, App. C Appendix C to Part 155—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan dealing with training is one of the key elements of a response plan. This concept is... included training as one of the sections required in a vessel or facility response plan. In reviewing...

Nuclear power reactor security personnel training and qualification plan reviewer workbook

International Nuclear Information System (INIS)

1979-06-01

The Training and Qualification Plan Reviewer Workbook has been developed to provide the information required for evaluating the adequacy of the Training and Qualification (T and Q) Plans developed to meet the requirements of 10 CFR 73.55(b)(4) and 10 CFR 73, Appendix B

Marketing and Distribution: What About Training Plans in the DE Project Laboratory?

Science.gov (United States)

Snyder, Ruth

1977-01-01

Managing a distributive education (DE) laboratory is a challenge. The laboratory is the simulated training station, with the instructor taking on the role of employer, managing student activities and learning. One tool to be utilized in managing a DE laboratory is a training plan. This article discusses the need for student training plans and the…

Role of Pharmacy Residency Training in Career Planning: A Student's Perspective.

Science.gov (United States)

McElhaney, Ashley; Weber, Robert J

2014-12-01

Pharmacy students typically become more focused on career planning and assessment in the final year of their PharmD training. Weighing career options in the advanced pharmacy practice experience year can be both exciting and stressful. The goal of this article is to provide a primer on how pharmacy students can assess how a residency can fit into career planning. This article will describe the various career paths available to graduating students, highlight ways in which a residency can complement career choices, review the current state of the job market for pharmacists, discuss the current and future plans for residency programs, and present thoughts from some current and former residents on why they chose to complete a residency. Most career paths require some additional training, and a residency provides appropriate experience very quickly compared to on-the-job training. Alternative plans to residency training must also be considered, as there are not enough residency positions for candidates. Directors of pharmacy must consider several factors when giving career advice on pharmacy residency training to pharmacy students; they should provide the students with an honest assessment of their work skills and their abilities to successfully complete a residency. This assessment will help the students to set a plan for improvement and give them a better chance at being matched to a pharmacy residency.

Plutonium finishing plant dangerous waste training plan

International Nuclear Information System (INIS)

ENTROP, G.E.

1999-01-01

This training plan describes general requirements, worker categories, and provides course descriptions for operation of the Plutonium Finish Plant (PFP) waste generation facilities, permitted treatment, storage and disposal (TSD) units, and the 90-Day Accumulation Areas

Planning and management support for NPP personnel SAT-based training programmes

International Nuclear Information System (INIS)

Ziakova, M.

1998-01-01

This paper deals with planning and management support for NPP personnel SAT based training programmes based on IAEA TC Project SLR/0/003 on upgrading NPP personnel training, with the aim of upgrading NPP safety and reliability of NPP operation and maintenance. The costs needed include both Slovak and IAEA sources. Five stages of the Project are defined: planning; organizing; motivating; implementation; control, review and accountability

Identification of training and emergency-planning needs through job-safety analysis

Energy Technology Data Exchange (ETDEWEB)

Veltrie, J.

1987-01-01

Training and emergency-planning needs within the photovoltaic industry may be more accurately determined through the performance of detailed job-safety analysis. This paper outlines the four major components of such an analysis, namely operational review, hazards evaluation, personnel review and resources evaluation. It then shows how these may be developed into coherent training and planning recommendations, for both emergency and non-emergency situations.

Training Effectiveness Assessment of Red Cape: Crisis Action Planning and Execution

National Research Council Canada - National Science Library

Schaefer, Peter S; Shadrick, Scott B; Beaubien, Jeff; Crabb, Brian T

2008-01-01

The crisis response training program Red Cape: Crisis Action Planning and Execution uses theme-based training and multimedia scenarios to instill expert thinking patterns in crisis response personnel...

Hanford Tanks Initiative AX tank farm cone penetrometer demonstration training plan

International Nuclear Information System (INIS)

Iwatate, D.F.

1998-01-01

The HTI subsurface characterization task will use the Hanford Cone Penetrometer platform (CPP) to deploy soil sensor and sampling probes into the vadose zone/soils around AX-104 during FY-99. This training plan identifies training requirements in support of the HTI task, describes specific staff training needs, and identifies how the training will be provided and by whom. Documentation of training completion is also described

Creating virtual humans for simulation-based training and planning

Energy Technology Data Exchange (ETDEWEB)

Stansfield, S.; Sobel, A.

1998-05-12

Sandia National Laboratories has developed a distributed, high fidelity simulation system for training and planning small team Operations. The system provides an immersive environment populated by virtual objects and humans capable of displaying complex behaviors. The work has focused on developing the behaviors required to carry out complex tasks and decision making under stress. Central to this work are techniques for creating behaviors for virtual humans and for dynamically assigning behaviors to CGF to allow scenarios without fixed outcomes. Two prototype systems have been developed that illustrate these capabilities: MediSim, a trainer for battlefield medics and VRaptor, a system for planning, rehearsing and training assault operations.

The Innate Insurgent Advantage: Can Training and Planning Bridge the Gap

Science.gov (United States)

2016-01-01

AIR UNIVERSITY AIR COMMAND AND STAFF COLLEGE The Innate Insurgent Advantage Can Training and Planning Bridge the Gap? Gary W. Boyd Department of...partners failed to adequately plan, train, or equip their individual forces until years after the start of the conflict . The objective of this research...Freedom (OEF) and Iraqi Freedom (OIF). Those three conflicts — along with Operation Allied Force, discreet operations following the Arab Spring, and

Training to the Nuclear emergency plans

International Nuclear Information System (INIS)

Vera Navascues, I.

2003-01-01

In 1994 the Civil Protection Directorate outlined a formation plan related to the Nuclear emergency plans with the purpose of guaranteeing for the communities involved in this material a basic and homogeneous formation. In the preparation of this Plan the following phases had been developed: 1. Study of formative needs of the different participant communities involved in nuclear plans. This has been done throw the information collected by: nuclear emergency plans and procedures that develop them, questionnaires, observation list, exercise, drills, etc. 2. With all the needs detected and in function of them was designed the objectives to teach in relation with the knowledge and the abilities that the formation can give to the participants. 3. Definition of thematic areas related with the different matters to teach, derived from the different objectives. 4. Organization: The development of the formative activities through a specific material with orientations for the professors (content of material to impart, didactic resources, etc.) and a short summary of the Didactic Units imparted to the students. The methodology is based in short theoretical classes and in the active implication through practice activities exercises and drills to train its functions and the coordination of the different implied organizations. 5. Evaluation: the implantation of the formation plan contributes new formative needs. (Author)

Long-term outcome and MGMT as a predictive marker in 24 patients with atypical pituitary adenomas and pituitary carcinomas given treatment with temozolomide

DEFF Research Database (Denmark)

Bengtsson, Daniel; Schrøder, Henrik Daa; Andersen, Marianne

2015-01-01

, GH 4, GH/PRL 2). Ki-67 was 2-50% in LAPTs, and 5-80% in carcinomas. MAIN OUTCOME: Response to TMZ and the association with tumor expression of O6-methylguanine DNA methyltransferase (MGMT), MLH1, MSH2, and MSH6, examined by immunohistochemistry. RESULTS: Complete tumor regression occurred in two...

B Plant Complex waste management training plan. Revision 1

International Nuclear Information System (INIS)

Beam, T.G.

1994-01-01

This training program is designed to comply with all applicable federal, state and US Department of Energy-Richland Operations Office training requirements. The training program complies with requirements contained within WAC 173-303-330 for the development of a written dangerous waste training program. The training program is designed to prepare personnel to manage and maintain waste treatment, storage and disposal (TSD) units, as well as generator units, in a safe, effective, efficient and environmentally sound manner. In addition to preparing employees to manage and maintain TSD and generator units under normal conditions, the training program ensures that employees are prepared to respond in a prompt and effective manner should an emergency occur. The training plan also identifies specific individuals holding key waste management positions at B Plant Complex

Comparing Written and Planned Training On Anxiety among Patients Undergoing Orthopedic Surgery

Directory of Open Access Journals (Sweden)

maryam tolyat

2017-03-01

Full Text Available Introduction and objectives: The prevalence of preoperative state anxiety is an unavoidable complication. Aside from its type and scope, the surgical operation is considered as a severe stressful situation for patients. Considering the importance of reducing the state anxiety in patients undergoing surgery, there are different methods, one of which is patient education; therefore the aim of the current study was compare the effect of written and planned training on the state anxiety among patients undergoing orthopedic surgery. Method: In this study, 81 patients candidate for orthopedic surgery were selected using convenience sampling and were randomly divided into 3 groups, including planned training, pamphlet and control groups. All patients answered 20 questions-State-Traits Anxiety Inventory (STAI Questionnaire the day before surgery and the intervention was later carried out in the planned training and pamphlet groups. Then the effect of preoperative state anxiety was re-evaluated about half an hour after training in three groups. For data analysis, in addition to mean and standard deviation, independent t-test and ANOVA were used in Spss16. Results: The results of comparing pre- and post-training mean score of the state anxiety in three groups showed that the mean score of state anxiety reached from 50.41 to 41.03, 52.41 to 44.37 and 45.04 to 50.56 in planned, pamphlet and control groups, respectively. ANOVA test showed that there is a significant difference in this comparison. The results of Tukey's test also revealed that the mean score of state anxiety in the planned and pamphlet groups was lower significantly than the control group (p<0.05. Conclusion: Based on research findings, the planned training method was more effective in decreasing state anxiety among patients compared to the pamphlet group before orthopedic surgery. Therefore, considering the fact that nurses play an important role in examining and relieving the state anxiety

Optimal trajectory planning and train scheduling for urban rail transit systems

CERN Document Server

Wang, Yihui; van den Boom, Ton; De Schutter, Bart

2016-01-01

This book contributes to making urban rail transport fast, punctual and energy-efficient –significant factors in the importance of public transportation systems to economic, environmental and social requirements at both municipal and national levels. It proposes new methods for shortening passenger travel times and for reducing energy consumption, addressing two major topics: (1) train trajectory planning: the authors derive a nonlinear model for the operation of trains and present several approaches for calculating optimal and energy-efficient trajectories within a given schedule; and (2) train scheduling: the authors develop a train scheduling model for urban rail systems and optimization approaches with which to balance total passenger travel time with energy efficiency and other costs to the operator. Mixed-integer linear programming and pseudospectral methods are among the new methods proposed for single- and multi-train systems for the solution of the nonlinear trajectory planning problem which involv...

30 CFR 48.23 - Training plans; time of submission; where filed; information required; time for approval; method...

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Training plans; time of submission; where filed... Surface Mines and Surface Areas of Underground Mines § 48.23 Training plans; time of submission; where... surface mine shall have an MSHA-approved plan containing programs for training new miners, training...

78 FR 979 - Petition for Positive Train Control Safety Plan Approval and System Certification of the...

Science.gov (United States)

2013-01-07

...] Petition for Positive Train Control Safety Plan Approval and System Certification of the Electronic Train... the Federal Railroad Administration (FRA) for Positive Train Control (PTC) Safety Plan (PTCSP) approval and system certification of the Electronic Train Management System (ETMS) as required by 49 U.S.C...

Astronauts McDivitt and White look over training plans

Science.gov (United States)

1965-01-01

Astronauts James A. McDivitt (left) and Edward H. White II are shown looking over training plans at Cape Kennedy during prelaunch preparations. The NASA Headquarters alternative photo number is 65-H-275.

Integrated Rolling Stock Planning for Suburban Passenger Trains

DEFF Research Database (Denmark)

Thorlacius, Per

used, the result being the loss of optimality. The talk will present a new, integrated rolling stock planning model in which the many requirements are handled all at the same time. Preliminary results from DSB S-tog, the suburban train operator of the City of Copenhagen will also be presented.......A central issue for operators of passenger trains is providing sufficient number of seats while minimising operating costs. This process must be conducted taking a large number of practical, railway oriented requirements into account. Because of this complexity, a stepwise solution was previously...

Advanced crew procedures development techniques: Procedures and performance program training plan

Science.gov (United States)

Arbet, J. D.; Benbow, R. L.

1975-01-01

A plan developed to support the training of PPP users in the operations associated with PPP usage is described. This document contains an overview of the contents of each training session and a detailed outline to be used as the guideline for each session.

Radiological Control Technician: Phase 1, Site academic training lesson plans

International Nuclear Information System (INIS)

1992-10-01

This volume provides lesson plans for training radiological control technicians. Covered here is basic radiological documentation, counting errors, dosimetry, environmental monitoring, and radiation instruments

30 CFR 48.3 - Training plans; time of submission; where filed; information required; time for approval; method...

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Training plans; time of submission; where filed....3 Training plans; time of submission; where filed; information required; time for approval; method... training plan shall be filed with the District Manager for the area in which the mine is located. (c) Each...

Management Plans for the UNESCO World Heritage Sites, Governance and Training

Directory of Open Access Journals (Sweden)

Claudio Ricci

2014-10-01

Full Text Available The presentation analyses the correlation between management, namely the coordination activities in the territorial framework of a UNESCO World Heritage Site, and training at different levels (professional training, political and management training and what patterns emerge from this relationship. A detailed analysis of the role, in this context, of the Management Plans is given, with a focus on the Italian experience.

Improving Training in Enterprise Resource Planning Systems Implementation through Communities of Practice

Science.gov (United States)

Kerr, Don; Burgess, Kevin J.; Houghton, Luke; Murray, Peter A.

2012-01-01

The Enterprise Resource Planning (ERP) literature suggests that effective training is one of the key reasons for success in ERP implementations. However, limited research has been conducted on what constitutes effective training in an ERP environment. A case study approach was used to explore the effectiveness of traditional training and to…

7 CFR 227.37 - State plan for nutrition education and training.

Science.gov (United States)

2010-01-01

... State program; (iii) criteria and procedure for selection of such representatives; (6) Plans to solicit....37 Section 227.37 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND... evaluation of the previous years' State plans for: (i) Inservice training of food service personnel, (ii...

Collaborative Optimization of Stop Schedule Plan and Ticket Allotment for the Intercity Train

Directory of Open Access Journals (Sweden)

Xichun Chen

2016-01-01

Full Text Available As regards the ticket allotment issue of the intercity passenger corridor designed for different train grades, the matching relationship between the ticket allotment and the passenger flow demand is studied. The passenger flow conversion equation which is based on the collaborative optimization of the intercity train stop schedule plan and ticket allotment is established. Then the mathematical model aiming at the maximum revenue of intercity train system and the highest satisfaction from the passengers is established. The particle swarm harmony search algorithm is designed to solve the model. The example verifies the effectiveness of the model and algorithm, which indicates that, through the collaborative optimization of the stop schedule plan and ticket allotment for different grades intercity trains, the sectional utilization rate of the train can be improved; meanwhile, the optimum matching between the intercity train revenue and the passenger satisfaction can be realized.

Radiographer-led plan selection for bladder cancer radiotherapy: initiating a training programme and maintaining competency.

Science.gov (United States)

McNair, H A; Hafeez, S; Taylor, H; Lalondrelle, S; McDonald, F; Hansen, V N; Huddart, R

2015-04-01

The implementation of plan of the day selection for patients receiving radiotherapy (RT) for bladder cancer requires efficient and confident decision-making. This article describes the development of a training programme and maintenance of competency. Cone beam CT (CBCT) images acquired on patients receiving RT for bladder cancer were assessed to establish baseline competency and training needs. A training programme was implemented, and observers were asked to select planning target volumes (PTVs) on two groups of 20 patients' images. After clinical implementation, the PTVs chosen were reviewed offline, and an audit performed after 3 years. A mean of 73% (range, 53-93%) concordance rate was achieved prior to training. Subsequent to training, the mean score decreased to 66% (Round 1), then increased to 76% (Round 2). Six radiographers and two clinicians successfully completed the training programme. An independent observer reviewed the images offline after clinical implementation, and a 91% (126/139) concordance rate was achieved. During the audit, 125 CBCT images from 13 patients were reviewed by a single observer and concordance was 92%. Radiographer-led selection of plan of the day was implemented successfully with the use of a training programme and continual assessment. Quality has been maintained over a period of 3 years. The training programme was successful in achieving and maintaining competency for a plan of the day technique.

Impact of partial participation in integrated family planning training on medical knowledge, patient communication and professionalism.

Science.gov (United States)

Steinauer, Jody E; Turk, Jema K; Preskill, Felisa; Devaskar, Sangita; Freedman, Lori; Landy, Uta

2014-04-01

Obstetrics and gynecology residency programs are required to provide access to abortion training, but residents can opt out of participating for religious or moral reasons. Quantitative data suggest that most residents who opt out of doing abortions participate and gain skills in other aspects of the family planning training. However, little is known about their experience and perspective. Between June 2010 and June 2011, we conducted semistructured interviews with current and former residents who opted out of some or all of the family planning training at ob-gyn residency programs affiliated with the Kenneth J. Ryan Residency Training Program in Abortion and Family Planning. Residents were either self-identified or were identified by their Ryan Program directors as having opted out of some training. The interviews were transcribed and coded using modified grounded theory. Twenty-six physicians were interviewed by telephone. Interviewees were from geographically diverse programs (35% Midwest, 31% West, 19% South/Southeast and 15% North/Northeast). We identified four dominant themes about their experience: (a) skills valued in the family planning training, (b) improved patient-centered care, (c) changes in attitudes about abortion and (d) miscommunication as a source of negative feelings. Respondents valued the ability to partially participate in the family planning training and identified specific aspects of their training which will impact future patient care. Many of the effects described in the interviews address core competencies in medical knowledge, patient care, communication and professionalism. We recommend that programs offer a spectrum of partial participation in family planning training to all residents, including residents who choose to opt out of doing some or all abortions. Learners who morally object to abortion but participate in training in family planning and abortion, up to their level of comfort, gain clinical and professional skills. We

Planning Training Loads for the 400 M Hurdles in Three-Month Mesocycles using Artificial Neural Networks.

Science.gov (United States)

Przednowek, Krzysztof; Iskra, Janusz; Wiktorowicz, Krzysztof; Krzeszowski, Tomasz; Maszczyk, Adam

2017-12-01

This paper presents a novel approach to planning training loads in hurdling using artificial neural networks. The neural models performed the task of generating loads for athletes' training for the 400 meters hurdles. All the models were calculated based on the training data of 21 Polish National Team hurdlers, aged 22.25 ± 1.96, competing between 1989 and 2012. The analysis included 144 training plans that represented different stages in the annual training cycle. The main contribution of this paper is to develop neural models for planning training loads for the entire career of a typical hurdler. In the models, 29 variables were used, where four characterized the runner and 25 described the training process. Two artificial neural networks were used: a multi-layer perceptron and a network with radial basis functions. To assess the quality of the models, the leave-one-out cross-validation method was used in which the Normalized Root Mean Squared Error was calculated. The analysis shows that the method generating the smallest error was the radial basis function network with nine neurons in the hidden layer. Most of the calculated training loads demonstrated a non-linear relationship across the entire competitive period. The resulting model can be used as a tool to assist a coach in planning training loads during a selected training period.

Planning Training Loads for The 400 M Hurdles in Three-Month Mesocycles Using Artificial Neural Networks

Directory of Open Access Journals (Sweden)

Przednowek Krzysztof

2017-12-01

Full Text Available This paper presents a novel approach to planning training loads in hurdling using artificial neural networks. The neural models performed the task of generating loads for athletes’ training for the 400 meters hurdles. All the models were calculated based on the training data of 21 Polish National Team hurdlers, aged 22.25 ± 1.96, competing between 1989 and 2012. The analysis included 144 training plans that represented different stages in the annual training cycle. The main contribution of this paper is to develop neural models for planning training loads for the entire career of a typical hurdler. In the models, 29 variables were used, where four characterized the runner and 25 described the training process. Two artificial neural networks were used: a multi-layer perceptron and a network with radial basis functions. To assess the quality of the models, the leave-one-out cross-validation method was used in which the Normalized Root Mean Squared Error was calculated. The analysis shows that the method generating the smallest error was the radial basis function network with nine neurons in the hidden layer. Most of the calculated training loads demonstrated a non-linear relationship across the entire competitive period. The resulting model can be used as a tool to assist a coach in planning training loads during a selected training period.

Training and Learning as Drivers of US Microenterprise Business Plan Quality

Science.gov (United States)

Cook, Ronald G.; Belliveau, Paul; Sandberg, Mark E.

2004-01-01

This study examined the output quality of a US microenterprise training program created to help entrepreneurs develop business plans for their ventures. The program concludes with the entrepreneurs' plans being scored by a panel of experts. Hypotheses were developed and tested to determine the importance of feedback, key components of business…

Spreadsheet Decision Support Model for Training Exercise Material Requirements Planning

National Research Council Canada - National Science Library

Tringali, Arthur

1997-01-01

... associated with military training exercises. The model combines the business practice of Material Requirements Planning and the commercial spreadsheet software capabilities of Lotus 1-2-3 to calculate the requirements for food, consumable...

EQUIP training the trainers: an evaluation of a training programme for service users and carers involved in training mental health professionals in user-involved care planning.

Science.gov (United States)

Fraser, C; Grundy, A; Meade, O; Callaghan, P; Lovell, K

2017-08-01

alongside ongoing support and supervision. Mental health nurses (and other health professionals) will be better able to involve service users and carers in care planning. Service users and carers may feel more involved in care planning in future. Introduction Limited evidence exists on service user and carer perceptions of undertaking a training course for delivering care planning training to qualified mental health professionals. We know little about trainee motivations for engaging with such train the trainers courses, experiences of attending courses and trainees' subsequent experiences of codelivering training to health professionals, hence the current study. Aim To obtain participants' views on the suitability and acceptability of a training programme that aimed to prepare service users and carers to codeliver training to health professionals. Method Semi-structured interviews with nine service users and carers attending the training programme. Transcripts were analysed using inductive thematic analysis. Results Participants' reasons for attending training included skill development and making a difference to mental health practice. Course content was generally rated highly but may benefit from review and/or extension to allow the range of topics and resulting professional training programme to be covered in more depth. Trainees who delivered the care planning training reported a mix of expectations, support experiences, preparedness and personal impacts. Implications for Practice Mental health nurses are increasingly coproducing and delivering training with service users and carers. This study identifies possibilities and pitfalls in this endeavour, highlighting areas where user and carer involvement and support structures might be improved in order to fully realize the potential for involvement in training. © 2017 The Authors. Journal of Psychiatric and Mental Health Nursing Published by John Wiley & Sons Ltd.

Case Study: Does training of private networks of Family Planning clinicians in urban Pakistan affect service utilization?

Science.gov (United States)

2010-01-01

Background To determine whether training of providers participating in franchise clinic networks is associated with increased Family Planning service use among low-income urban families in Pakistan. Methods The study uses 2001 survey data consisting of interviews with 1113 clinical and non-clinical providers working in public and private hospitals/clinics. Data analysis excludes non-clinical providers reducing sample size to 822. Variables for the analysis are divided into client volume, and training in family planning. Regression models are used to compute the association between training and service use in franchise versus private non-franchise clinics. Results In franchise clinic networks, staff are 6.5 times more likely to receive family planning training (P = 0.00) relative to private non-franchises. Service use was significantly associated with training (P = 0.00), franchise affiliation (P = 0.01), providers' years of family planning experience (P = 0.02) and the number of trained staff working at government owned clinics (P = 0.00). In this setting, nurses are significantly less likely to receive training compared to doctors (P = 0.00). Conclusions These findings suggest that franchises recruit and train various cadres of health workers and training maybe associated with increased service use through improvement in quality of services. PMID:21062460

Case Study: Does training of private networks of Family Planning clinicians in urban Pakistan affect service utilization?

Directory of Open Access Journals (Sweden)

Qureshi Asma M

2010-11-01

Full Text Available Abstract Background To determine whether training of providers participating in franchise clinic networks is associated with increased Family Planning service use among low-income urban families in Pakistan. Methods The study uses 2001 survey data consisting of interviews with 1113 clinical and non-clinical providers working in public and private hospitals/clinics. Data analysis excludes non-clinical providers reducing sample size to 822. Variables for the analysis are divided into client volume, and training in family planning. Regression models are used to compute the association between training and service use in franchise versus private non-franchise clinics. Results In franchise clinic networks, staff are 6.5 times more likely to receive family planning training (P = 0.00 relative to private non-franchises. Service use was significantly associated with training (P = 0.00, franchise affiliation (P = 0.01, providers' years of family planning experience (P = 0.02 and the number of trained staff working at government owned clinics (P = 0.00. In this setting, nurses are significantly less likely to receive training compared to doctors (P = 0.00. Conclusions These findings suggest that franchises recruit and train various cadres of health workers and training maybe associated with increased service use through improvement in quality of services.

Case Study: Does training of private networks of Family Planning clinicians in urban Pakistan affect service utilization?

Science.gov (United States)

Qureshi, Asma M

2010-11-09

To determine whether training of providers participating in franchise clinic networks is associated with increased Family Planning service use among low-income urban families in Pakistan. The study uses 2001 survey data consisting of interviews with 1113 clinical and non-clinical providers working in public and private hospitals/clinics. Data analysis excludes non-clinical providers reducing sample size to 822. Variables for the analysis are divided into client volume, and training in family planning. Regression models are used to compute the association between training and service use in franchise versus private non-franchise clinics. In franchise clinic networks, staff are 6.5 times more likely to receive family planning training (P = 0.00) relative to private non-franchises. Service use was significantly associated with training (P = 0.00), franchise affiliation (P = 0.01), providers' years of family planning experience (P = 0.02) and the number of trained staff working at government owned clinics (P = 0.00). In this setting, nurses are significantly less likely to receive training compared to doctors (P = 0.00). These findings suggest that franchises recruit and train various cadres of health workers and training maybe associated with increased service use through improvement in quality of services.

Proposed plan for education and training in nonnuclear and nuclear energy technologies

International Nuclear Information System (INIS)

Vachon, R.I.; Griffith, D.E.

1977-02-01

This report presents the results of a systems approach by an ERDA/ASEE Task Force to a charge from the 94th Congress to the Energy Research and Development Administration to develop a plan for a comprehensive program for education and training in nonnuclear energy technologies. The PLAN as presented is the recommendation of the Task Force and is not to be construed as the ERDA Plan. The interpretation of the charge leads to the following definitive statements. The PLAN should consist of a program and organizational and administrative means within ERDA to develop and manage the program. The program should: (1) include general educational subprograms, vocational skill subprograms to degree and post degree programs; (2) include nuclear as well as nonnuclear education and training; (3) encourage, assist, and utilize all institutions from labor unions to universities to assure educated and trained manpower to meet the nation's energy needs; (4) be catalytic in nature and rely not only on funding as a catalytic agent but also on information and leadership; (5) give equal opportunity to all seeking or needing education and training to become a part of the energy labor market in all regions of the nation; (6) be supplementary to what can be accomplished by the private sector; (7) promote interaction between ERDA and other Federal government agencies and state and local governments; (8) be responsive as well as anticipatory; (9) be applicable from energy resource exploration to energy and use; and (10) provide for input and feedback from the private sector

38 CFR 21.8072 - Authorizing training, services, and assistance beyond the initial individualized written plan of...

Science.gov (United States)

2010-07-01

... Authorizing training, services, and assistance beyond the initial individualized written plan of vocational... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Authorizing training, services, and assistance beyond the initial individualized written plan of vocational rehabilitation. 21...

Waste Encapsulation and Storage Facility (WESF) Dangerous Waste Training Plan (DWTP)

International Nuclear Information System (INIS)

SIMMONS, F.M.

1999-01-01

This training plan describes general requirements, worker categories, and provides course descriptions for operation of the WESF permitted miscellaneous storage units, and the < 90 day accumulation areas

America COMPETES at 5 years: An Analysis of Research-Intensive Universities' RCR Training Plans.

Science.gov (United States)

Phillips, Trisha; Nestor, Franchesca; Beach, Gillian; Heitman, Elizabeth

2018-02-01

This project evaluates the impact of the National Science Foundation's (NSF) policy to promote education in the responsible conduct of research (RCR). To determine whether this policy resulted in meaningful RCR educational experiences, our study examined the instructional plans developed by individual universities in response to the mandate. Using a sample of 108 U.S. institutions classified as Carnegie "very high research activity", we analyzed all publicly available NSF RCR training plans in light of the consensus best practices in RCR education that were known at the time the policy was implemented. We found that fewer than half of universities developed plans that incorporated at least some of the best practices. More specifically, only 31% of universities had content and requirements that differed by career stage, only 1% of universities had content and requirements that differed by discipline; and only 18% of universities required some face-to-face engagement from all classes of trainees. Indeed, some schools simply provided hand-outs to their undergraduate students. Most universities (82%) had plans that could be satisfied with online programs such as the Collaborative Institutional Training Initiative's RCR modules. The NSF policy requires universities to develop RCR training plans, but provides no guidelines or requirements for the format, scope, content, duration, or frequency of the training, and does not hold universities accountable for their training plans. Our study shows that this vaguely worded policy, and lack of accountability, has not produced meaningful educational experiences for most of the undergraduate students, graduate students, and post-doctoral trainees funded by the NSF.

Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.

Science.gov (United States)

Pierini, Stefano; Jordanov, Stanislav H; Mitkova, Atanaska V; Chalakov, Ivan J; Melnicharov, Mincho B; Kunev, Kuncho V; Mitev, Vanio I; Kaneva, Radka P; Goranova, Teodora E

2014-08-01

Laryngeal squamous cell carcinoma (laryngeal SCC) is a frequently occurring cancer of the head and neck area. Epigenetic changes of tumor-related genes contribute to its genesis and progression. We assessed promoter methylation status of the selected genes (CDKN2A, MGMT, MLH1, and DAPK) using methylation-sensitive high resolution melting (MS-HRM) in 100 patients with laryngeal SCC and studied the correlations with clinical characteristics. The prevalence of promoter methylation in MGMT, CDKN2A, MLH1, and DAPK was 59 of 97 (60.8%), 46 of 97 (47.4%), 45 of 97 (46.4%), and 41 of 97 patients (42.3%), respectively. Significantly increased methylation of CDKN2A was observed in heavy smokers. Epigenetic inactivation of CDKN2A and MLH1 were found to be associated with lymph node involvement. An inverse correlation was present between MLH1 methylation and alcohol consumption. Our results strongly suggest that deregulation of p16-associated, and MLH1-associated pathways, because of promoter hypermethylation, is associated with increased cancer cell migration, tumor invasiveness, and, thus, aggressive phenotype. Copyright © 2013 Wiley Periodicals, Inc.

<90 day storage training plan for the 103-B, 1701-BA, AND 1714-C buildings

International Nuclear Information System (INIS)

Snider, P.M.

1996-10-01

The 103-B, 1701-BA, and 1714C < 90 Day Storage Area stores characteristic wastes generated in the demolition of the 103-B, 1701-BA, and 1714-C Complex. Wastes (lead-based painted components) are packaged and stored in vendor shipment containers. This is the Environmental Restoration Contractor team training plan for the 103-B, 1701-BA, and 1714-C subgrade demolition < 90 Day Storage of Hazardous Waste. This document is intended to meet the requirements of Washington Administrative Code 173-303-330 and the Hanford Dangerous Waste Permit. Training unrelated to compliance with WAC 173-303-330 is not addressed in this training plan. WAC 173-303-330(1)(d)(2, 5, 6) requires that personnel be familiarized, where applicable, with waste feed cut-off systems, response to ground-water contamination incidents, and shutdown of operations. These are not applicable to 103-B, 1701-BA, and 1714-C Subgrade Demolition < 90 Day Storage, and therefore are not covered in this training plan

3D planning and radiation oncology residents' training

International Nuclear Information System (INIS)

Jayaraman, Subramania

1991-01-01

Radiation treatments in radiation oncology clinics have been always planned to irradiate three dimensional (3D) volumes. Though the term 3D planning has come in vogue only in recent years, the essence of 3D planning had been always there. This is because the patient is a 3D subject and every treatment option adopted in a radiotherapy clinic has to be based on a 3D judgement of its acceptability. An essential aspect of training of radiation oncology residents is to help them understand the different techniques and methods used to get an acceptable 3D dose delivery. The tools of 3D planning should be introduced to the residents for their educational value. The regular use of these tools may require not only fast computers and work stations, but also a change of routine in the department. This might be difficult since the departmental routine can evolve only gradually. On the other hand, an insight about the advantages of the tools could be gained through a simple personal computer. Some examples of using the 3D planning tools through a personal computer, for educational purposes have been presented here, using clinical contexts routinely encountered. (author). 5 refs., 10 figs

Routine training is not enough: structured training in family planning and abortion improves residents' competency scores and intentions to provide abortion after graduation more than ad hoc training.

Science.gov (United States)

Macisaac, Laura; Vickery, Zevidah

2012-03-01

Abortion provision remains threatened by the paucity of physicians trained to provide them. Lack of training during residency has been cited by obstetrician and gynecologist (ob-gyn) physicians as a reason for not including abortion in their practice. We administered surveys on interest, competency and intention to provide abortions to two groups of ob-gyn residents: one experiencing a new comprehensive and structured family planning rotation, and another group at our affiliate hospital's residency program receiving "ad hoc" training during their routine gynecology rotations. Surveys were anonymous and blinded to investigator. The structured family planning rotation group compared to the ad hoc group reported significantly increased competency score using a Likert scale in manual vacuum aspiration (MVA) (4.5 vs. 1; p=.003) and had a higher proportion reporting intent to provide office MVA postresidency (100% vs. 39%; p=.01) and being trained to 22.5 weeks' vs. 12 weeks' gestation (p=.005). In bivariate analysis, competency in MVA was associated with higher intentions to provide MVA after residency (p=.007). A structured rotation in family planning and abortion for obstetrics/gynecology residents results in increases in competency and intentions to provide abortion, and an association between the two. In-hospital structured training proved to be superior to ad hoc training in our affiliate institution in improving competency and intention to provide abortion after residency. Copyright © 2012 Elsevier Inc. All rights reserved.

Planning and management support for NPP personnel SAT-based training programmes

International Nuclear Information System (INIS)

Ziakova, M.

1998-01-01

Planning and management support for NPP personnel SAT-based training programmes is described for the following job positions: reactor operator; turbine operator; reactor maintenance worker; pump maintenance worker; chemistry foreman; health physics foreman; electric maintenance worker

Plutonium Finishing Plant Treatment and Storage Unit Dangerous Waste Training Plan

International Nuclear Information System (INIS)

ENTROP, G.E.

2000-01-01

The training program for personnel performing waste management duties pertaining to the Plutonium Finishing Plant (PFP) Treatment and Storage Unit is governed by the general requirements established in the Plutonium Finishing Plant Dangerous Waste Training Plan (PFP DWTP). The PFP Treatment and Storage Unit DWTP presented below incorporates all of the components of the PFP DWTP by reference. The discussion presented in this document identifies aspects of the training program specific to the PFP Treatment and Storage Unit. The training program includes specifications for personnel instruction through both classroom and on-the-job training. Training is developed specific to waste management duties. Hanford Facility personnel directly involved with the PFP Treatment and Storage Unit will receive training to container management practices, spill response, and emergency response. These will include, for example, training in the cementation process and training pertaining to applicable elements of WAC 173-303-330(1)(d). Applicable elements from WAC 173-303-330(1)(d) for the PFP Treatment and Storage Unit include: procedures for inspecting, repairing, and replacing facility emergency and monitoring equipment; communications and alarm systems; response to fires or explosions; and shutdown of operations

Integrated surgical emergency training plan in the internship: A step toward improving the quality of training and emergency center management.

Science.gov (United States)

Akhlaghi, Mohammad Reza; Vafamehr, Vajiheh; Dadgostarnia, Mohammad; Dehghani, Alireza

2013-01-01

In this study, by using a problem-oriented approach in the needs assessment, identifying the defects and deficiencies in emergency health training centers has been determined as the basis for the requirements. The main objective of the study was the implementation of surgical emergencies integration of the five surgical groups (general surgery, urology, orthopedics, neurosurgery, and ENT) to meet the needs and determining its efficacy. THIS INTERVENTIONAL STUDY WAS CONDUCTED IN THREE PHASES: (1) Phase I (design and planning): Needs assessment, recognition of implementation barriers and providing the objectives and training program for integrated emergencies. (2) Phase II (implementation): Justification of the main stakeholders of the project, preparation of students' duties in the emergency department, preparation of on-duty plans, supervising the implementation of the program, and reviewing the plan in parallel with the implementation based on the problems. (3) Phase III (evaluation): Reviewing the evidences based on the amount of efficiency of the plan and justification for its continuation. In the first and the second phase, the data were collected through holding focus group meetings and interviews. In the third phase, the opened-reply and closed-reply researcher-made questionnaires were used. The questionnaire face and content validity were confirmed by experts and the reliability was assessed by calculating the Cronbach's alpha. ACCORDING TO THE VIEWS OF THE INTERNS, ASSISTANTS, TEACHERS, AND EMERGENCY PERSONNEL, THE POSITIVE FEATURES OF THE PLAN INCLUDED THE FOLLOWING: Increasing the patients' satisfaction, reducing the patients' stay in the Emergency Department, increasing the speed of handling the patients, balancing the workloads of the interns, direct training of interns by young teachers of emergency medicine, giving the direct responsibility of the patient to the intern, practical and operational training of emergency issues, increasing the teamwork

Stormwater Management Plan for the Arden Hills Army Training Site, Arden Hills, Minnesota

Energy Technology Data Exchange (ETDEWEB)

Carr, Adrianne E. [Argonne National Lab. (ANL), Argonne, IL (United States); Wuthrich, Kelsey K. [Argonne National Lab. (ANL), Argonne, IL (United States); Ziech, Angela M. [Argonne National Lab. (ANL), Argonne, IL (United States); Bowen, Esther E. [Argonne National Lab. (ANL), Argonne, IL (United States); Quinn, John [Argonne National Lab. (ANL), Argonne, IL (United States)

2013-03-01

This stormwater management plan focuses on the cantonment and training areas of the Arden Hills Army Training Site (AHATS). The plan relates the site stormwater to the regulatory framework, and it summarizes best management practices to aide site managers in promoting clean site runoff. It includes documentation for a newly developed, detailed model of stormwater flow retention for the entire AHATS property and adjacent upgradient areas. The model relies on established modeling codes integrated in a U.S. Department of Defense-sponsored software tool, the Watershed Modeling System (WMS), and it can be updated with data on changes in land use or with monitoring data.

Training of Family Planning Counselors in Jordan: Developing Human Resources through Adult Education

Science.gov (United States)

Jabbar, Sinaria Kamil Abdel

2012-01-01

This paper briefly describes the development and status of family planning (FP) services, including counseling, in the Hashemite Kingdom of Jordan. It also reports extensively on a FP counseling training course organized by the Jordanian Association for Family Planning and Protection (JAFPP) which is a local NGO. A field survey approach, with…

A Preliminary Study on the Effects of Training Using Behavior Support Plan Quality Evaluation Guide (BSP-QE) to Improve Positive Behavioral Support Plans

Science.gov (United States)

Wright, Diana Browning; Mayer, G. Roy; Cook, Clayton R.; Crews, S. Dean; Kraemer, Bonnie Rawlings; Gale, Bruce

2007-01-01

The purpose of this research was to evaluate the effects of two trainings designed to increase the competencies of professionals to develop high quality positive behavior support plans for students that engage in problem behaviors that interfere with theirs and/or others' ability to learn. Training one consisted of training attendees on six key…

Integrated Optimization of Service-Oriented Train Plan and Schedule on Intercity Rail Network with Varying Demand

Directory of Open Access Journals (Sweden)

Wenliang Zhou

2015-01-01

Full Text Available For a better service level of a train operating plan, we propose an integrated optimization method of train planning and train scheduling, which generally are optimized, respectively. Based on the cost analysis of both passengers travelling and enterprises operation, and the constraint analysis of trains operation, we construct a multiobjective function and build an integrated optimization model with the aim of reducing both passenger travel costs and enterprise operating costs. Then, a solving algorithm is established based on the simulated annealing algorithm. Finally, using as an example the Changzhutan intercity rail network, as an example we analyze the optimized results and the influence of the model parameters on the results.

29 CFR 5.16 - Training plans approved or recognized by the Department of Labor prior to August 20, 1975.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Training plans approved or recognized by the Department of... STANDARDS ACT) Davis-Bacon and Related Acts Provisions and Procedures § 5.16 Training plans approved or... contractor shall be required to obtain approval of a training program which, prior to August 20, 1975, was...

5 CFR 2638.706 - Agency's written plan for annual ethics training.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Agency's written plan for annual ethics training. 2638.706 Section 2638.706 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Executive Agency Ethics...

METHODOLOGY OF DETERMINATION OF ADMISSIBLE SPEEDS OF TRAIN MOVEMENT ON DIFFICULT SECTIONS OF RAILROAD PLAN

Directory of Open Access Journals (Sweden)

M. B. Kurhan

2014-03-01

Full Text Available Purpose. Determination of improvement ways of admissible speeds of train movement on the difficult sections of а railroad plan. Methodology. Mathematical modeling of the train traffic is used to achieve the purpose of research. The average weighted speed and elevation of outer rail is predicted on this basis. Findings. The case analysis of the speeds determination in curved sections of track was carried out. The above mentioned track sections adversely affect the ride comfort and the intensity of the way disorder, as well as the reasons that contribute to the speed limits traffic on the railways of Ukraine. The technique of performing the calculations for determining the permissible train speeds was developed and tested on real curves of railways, were the accelerated movement of trains was introduced. Proposals on automate calculations in distances and services by way of determining the permissible speeds in curves were developed. Originality. Methodology of determining the permissible motion speeds and elevation of outer rails on the difficult sections of the railway plan was developed. This approach allows you to get a rational decisions on reorganization of plan based on local conditions. Practical value. The developed technique of definition of admissible speeds of motion in curves was implemented as a program DopShvid. The program was tested on real railway sections, where the accelerated train motion was introduced.

Offering the full range of contraceptive options: a survey of interest in vasectomy training in the US family planning community.

Science.gov (United States)

Nguyen, Brian T; Jochim, Andrea L; Shih, Grace H

2017-05-01

To assess current practices regarding female and male sterilization counseling and provision, as well as determine interest in providing vasectomy among family planning specialists. Members of the US-based network of family planning fellowship physicians (current fellows, graduates and faculty) received a Web-based survey from November 2015 through January 2016 regarding current sterilization preferences and practices, as well as interest in obtaining training in vasectomy counseling and procedure. Nearly 60% (n=178/302) of family planning fellowship providers responded to the survey. While 62% (111/178) of respondents reported counseling their patients about vasectomy at least most of the time and 57% (102/178) recommended vasectomy over female sterilization, few (8/178; 4 trained in family medicine and 4 trained in obstetrics and gynecology) had performed a vasectomy in the last year. Nearly 90% (158/178) of respondents were somewhat or very interested in receiving training on vasectomy counseling; 58% (103/178) desired procedural training. Desire for training was associated with being male and receiving residency training in family medicine. Few family planning fellowship physicians provide vasectomy, and the majority expressed being at least somewhat interested in receiving further training. Vasectomy is more effective, safer and less expensive than female sterilization but is less common than female sterilization. One barrier to vasectomy access is the low number of vasectomy providers. Creating a structured vasectomy training program through the family planning fellowship may help to increase the number of vasectomy providers. Copyright © 2017 Elsevier Inc. All rights reserved.

Reflective Lesson Planning in Refresher Training Programs for Experienced Physics Teachers.

Science.gov (United States)

Chung, C. M.; And Others

1995-01-01

Reports on a refresher training program that introduces experienced physics teachers to a reflective lesson-planning model and a more constructivist approach to physics teaching. Three instructional strategies developed by participants in the program and the corresponding suggestions made by their peers are presented and analyzed. (29 references)…

Evaluation of a co-delivered training package for community mental health professionals on service user- and carer-involved care planning.

Science.gov (United States)

Grundy, A C; Walker, L; Meade, O; Fraser, C; Cree, L; Bee, P; Lovell, K; Callaghan, P

2017-08-01

WHAT IS KNOWN ON THE SUBJECT?: There is consistent evidence that service users and carers feel marginalized in the process of mental health care planning. Mental health professionals have identified ongoing training needs in relation to involving service users and carers in care planning. There is limited research on the acceptability of training packages for mental health professionals which involve service users and carers as co-facilitators. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: A co-produced and co-delivered training package on service user- and carer-involved care planning was acceptable to mental health professionals. Aspects of the training that were particularly valued were the co-production model, small group discussion and the opportunity for reflective practice. The organizational context of care planning may need more consideration in future training models. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Mental health nurses using co-production models of delivering training to other mental health professionals can be confident that such initiatives will be warmly welcomed, acceptable and engaging. On the basis of the results reported here, we encourage mental health nurses to use co-production approaches more often. Further research will show how clinically effective this training is in improving outcomes for service users and carers. Background There is limited evidence for the acceptability of training for mental health professionals on service user- and carer-involved care planning. Aim To investigate the acceptability of a co-delivered, two-day training intervention on service user- and carer-involved care planning. Methods Community mental health professionals were invited to complete the Training Acceptability Rating Scale post-training. Responses to the quantitative items were summarized using descriptive statistics (Miles, ), and qualitative responses were coded using content analysis (Weber, ). Results Of 350 trainees, 310 completed the

Does Academic Training Change Intentions? Drawing upon the Theory of Planned Behaviour to Improve Academic Performance

Science.gov (United States)

Hodge, Brad; Wright, Brad; Bennett, Pauleen

2017-01-01

In order to improve transfer following training, it is important to understand what the training alters for each individual. We sought to develop a better understanding of the underlying mechanisms implicated in successful training. A questionnaire modelled on the Theory of Planned Behaviour (ToPB) was used to compare two distinct, academic skills…

Utility of learning plans in general practice vocational training: a mixed-methods national study of registrar, supervisor, and educator perspectives.

Science.gov (United States)

Garth, Belinda; Kirby, Catherine; Silberberg, Peter; Brown, James

2016-08-19

Learning plans are a compulsory component of the training and assessment requirements of general practice (GP) registrars in Australia. There is a small but growing number of studies reporting that learning plans are not well accepted or utilised in general practice training. There is a lack of research examining this apparent contradiction. The aim of this study was to examine use and perceived utility of formal learning plans in GP vocational training. This mixed-method Australian national research project utilised online learning plan usage data from 208 GP registrars and semi-structured focus groups and telephone interviews with 35 GP registrars, 12 recently fellowed GPs, 16 supervisors and 17 medical educators across three Regional Training Providers (RTPs). Qualitative data were analysed thematically using template analysis. Learning plans were used mostly as a log of activities rather than as a planning tool. Most learning needs were entered and ticked off as complete on the same day. Learning plans were perceived as having little value for registrars in their journey to becoming a competent GP, and as a bureaucratic hurdle serving as a distraction rather than an aid to learning. The process of learning planning was valued more so than the documentation of learning planning. This study provides creditable evidence that mandated learning plans are broadly considered by users to be a bureaucratic impediment with little value as a learning tool. It is more important to support registrars in planning their learning than to enforce documentation of this process in a learning plan. If learning planning is to be an assessed competence, methods of assessment other than the submission of a formal learning plan should be explored.

Training gaps for pediatric residents planning a career in primary care: a qualitative and quantitative study.

Science.gov (United States)

Rosenberg, Adam A; Kamin, Carol; Glicken, Anita Duhl; Jones, M Douglas

2011-09-01

Resident training in pediatrics currently entails similar training for all residents in a fragmented curriculum with relatively little attention to the career plans of individual residents. To explore strengths and gaps in training for residents planning a career in primary care pediatrics and to present strategies for addressing the gaps. Surveys were sent to all graduates of the University of Colorado Denver Pediatric Residency Program (2003-2006) 3 years after completion of training. Respondents were asked to evaluate aspects of their training, using a 5-point Likert scale and evaluating each item ranging from "not at all well prepared" to "extremely well prepared" for their future career. In addition, focus groups were conducted with practitioners in 8 pediatric practices in Colorado. Sessions were transcribed and hand coded by 2 independent coders. Survey data identified training in behavior and development (mean score, 3.72), quality improvement and patient safety strategies (mean, 3.57), and practice management (mean, 2.46) as the weakest aspects of training. Focus groups identified deficiencies in training in mental health, practice management, behavioral medicine, and orthopedics. Deficiencies noted in curriculum structure were lack of residents' long-term continuity of relationships with patients; the need for additional training in knowledge, skills, and attitudes needed for primary care (perhaps even a fourth year of training); and a training structure that facilitates greater resident autonomy to foster development of clinical capability and self-confidence. Important gaps were identified in the primary care training of pediatric residents. These data support the need to develop more career-focused training.

Annual training manual for security training: Protective force

Energy Technology Data Exchange (ETDEWEB)

1990-10-01

Westinghouse is committed to high quality training relevant to the need of the Protective Forces at the Waste Isolation Pilot Plant (WIPP). The training programs at WIPP are designed to qualify Security personnel to perform WIPP security missions in a professional and responsible manner. The program consists of basic as well as sustainment training, as further described in this plan. This plan documents the WIPP Security training program for security personnel for calendar year 1990. The programs detailed in this plan are designed to adequately train persons to ensure the uninterrupted continuity of Department of Energy (DOE)/Westinghouse operations. The Security Training Program consists of four basic elements. These elements are (1) basic level training; (2) on-the-job training; (3) refresher training; and (4) in-service training.

Training Community Modeling and Simulation Business Plan, 2007 Edition. Volume 2: Data Call Responses and Analysis

Science.gov (United States)

2009-02-01

services; and • Other reconstruction assistance. D-14 17. Train Forces on Military Assistance to Civil Authorities ( MACA ) Develop environments...for training in the planning and execution of MACA in support of disaster relief (natural and man-made), military assistance for civil disturbances

Highly Efficient Training, Refinement, and Validation of a Knowledge-based Planning Quality-Control System for Radiation Therapy Clinical Trials

Energy Technology Data Exchange (ETDEWEB)

Li, Nan; Carmona, Ruben [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States); Sirak, Igor; Kasaova, Linda [Department of Oncology and Radiotherapy, University Hospital, Hradec Kralove (Czech Republic); Followill, David [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Michalski, Jeff; Bosch, Walter; Straube, William [Department of Radiation Oncology, Washington University in St Louis, St Louis, Missouri (United States); Mell, Loren K. [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States); Moore, Kevin L., E-mail: kevinmoore@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States)

2017-01-01

Purpose: To demonstrate an efficient method for training and validation of a knowledge-based planning (KBP) system as a radiation therapy clinical trial plan quality-control system. Methods and Materials: We analyzed 86 patients with stage IB through IVA cervical cancer treated with intensity modulated radiation therapy at 2 institutions according to the standards of the INTERTECC (International Evaluation of Radiotherapy Technology Effectiveness in Cervical Cancer, National Clinical Trials Network identifier: 01554397) protocol. The protocol used a planning target volume and 2 primary organs at risk: pelvic bone marrow (PBM) and bowel. Secondary organs at risk were rectum and bladder. Initial unfiltered dose-volume histogram (DVH) estimation models were trained using all 86 plans. Refined training sets were created by removing sub-optimal plans from the unfiltered sample, and DVH estimation models… and DVH estimation models were constructed by identifying 30 of 86 plans emphasizing PBM sparing (comparing protocol-specified dosimetric cutpoints V{sub 10} (percentage volume of PBM receiving at least 10 Gy dose) and V{sub 20} (percentage volume of PBM receiving at least 20 Gy dose) with unfiltered predictions) and another 30 of 86 plans emphasizing bowel sparing (comparing V{sub 40} (absolute volume of bowel receiving at least 40 Gy dose) and V{sub 45} (absolute volume of bowel receiving at least 45 Gy dose), 9 in common with the PBM set). To obtain deliverable KBP plans, refined models must inform patient-specific optimization objectives and/or priorities (an auto-planning “routine”). Four candidate routines emphasizing different tradeoffs were composed, and a script was developed to automatically re-plan multiple patients with each routine. After selection of the routine that best met protocol objectives in the 51-patient training sample (KBP{sub FINAL}), protocol-specific DVH metrics and normal tissue complication probability were compared for original

29 CFR 2520.104-22 - Exemption from reporting and disclosure requirements for apprenticeship and training plans.

Science.gov (United States)

2010-07-01

... disclosure requirements for apprenticeship and training plans. (a) An employee welfare benefit plan that...) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR REPORTING AND DISCLOSURE UNDER THE EMPLOYEE... information required to be contained in such notice is disclosed to employees of employers contributing to the...

Project plan, Hazardous Materials Management and Emergency Response Training Center: Project 95L-EWT-100

International Nuclear Information System (INIS)

Borgeson, M.E.

1994-01-01

The Hazardous Materials Management and Emergency Response (HAMMER) Training Center will provide for classroom lectures and hands-on practical training in realistic situations for workers and emergency responders who are tasked with handling and cleanup of toxic substances. The primary objective of the HAMMER project is to provide hands-on training and classroom facilities for hazardous material workers and emergency responders. This project will also contribute towards complying with the planning and training provisions of recent legislation. In March 1989 Title 29 Code of Federal Regulations Occupational Safety and Health Administration 1910 Rules and National Fire Protection Association Standard 472 defined professional requirements for responders to hazardous materials incidents. Two general types of training are addressed for hazardous materials: training for hazardous waste site workers and managers, and training for emergency response organizations

Interim Corrective Measures Work Plan for the Expanded Bioventing System Eglin Main Base Old Fire Training Area

National Research Council Canada - National Science Library

1997-01-01

This interim corrective measures work plan (ICM work plan) presents the scope for an expanded bioventing system for in situ treatment of fuel-contaminated soils at the Eglin Main Base Old Fire Training Area (old Eglin FTA...

Training of Prospective Managers by Educational Institutions for Strategic Planning at the Stage of Studying for a Master’s Degree

Directory of Open Access Journals (Sweden)

Tamara R. Gumennikova

2015-08-01

Full Text Available In the given article the attention is focused on training of master’s degree students – prospective managers of an enterprise, institution, organization (in the field of education and industrial training for strategic planning by an educational institution.Ways of methodological accompaniment of educational manager’s training for strategic planning are presented. Fragments of systemic work of master’s degree teachers in the plane of the problem under investigation are demonstrated on actual examples.

Challenges and Approaches in River Delta Planning - Annexes to report on training workshop

NARCIS (Netherlands)

Wosten, J.H.M.; Douven, W.; Long Phi, H.; Fida Abdullah Khan, M.

2012-01-01

Programme, participants and all powerpoint presentations of the Delta Alliance Training Workshop: Challenges and approaches in river delta planning, sharing experiences from SE Asian Deltas and the Rhine-Meuse Delta. 22-26 October 2012, WACC, Vietnam National University, Ho Chi Minh City, Vietnam

Training, abilities, role and responsibilities of the technician in treatment planning or 'dosimetrist' in radiotherapy

International Nuclear Information System (INIS)

Buchheit, Isabelle; Angles, Damien; Marchesi, Vincent; Fau, Pierre; Aubignac, Leone; Palisson, Jeremy; Lacornerie, Thomas; Baron, Pierre-Louis; Popoff, Romain; Llagostera, Camille; Buffard, Edwige; Sarrazin, Thierry; Le Du, Dominique; Estivalet, Andre; Tchong, Bruno; Marcie, Serge; Guerin, Lucie; Parent, Laure

2013-09-01

As the creation of treatment plans in radiotherapy (commonly named dosimetry) has become a crucial task in the treatment process, and has been historically performed by the medical physician, it may be delegated to other professionals and there is therefore a need of creation of a profession: the technician in treatment planning or dosimetrist. In order to better define this profession, its role and its education and training requirements, this document describes its role, its required knowledge, abilities and capacities (general knowledge, knowledge in anatomy, oncology and imagery, in radiation production, in ballistic and preparation, in radiotherapy, in breath-based feedback, in body irradiation, in radiation protection, in delimitation of organs at risk, and in administrative issues). The different training levels are indicated: initial training, continuous training, and validation of prior experience. The legal framework and organisational issues are addressed in terms of delegation and responsibility

Management and training aspects of the emergency plan

International Nuclear Information System (INIS)

Lakey, J.R.A.

1996-01-01

The main objectives of an emergency management system are to prevent or reduce the likelihood of consequential loss in the event of an emergency occurring. In the event of a nuclear accident the effectiveness of measures for the protection of the public will depend on the advance preparation especially in education and training. This paper reviews two recent initiatives and concludes with comments on the future development of this subject. There is an increasing requirement in legal and moral terms for industry to inform the population of health hazards to which they are exposed. In a report published by the Nuclear Energy Agency (NEA/OECD) radiation protection was described as a subject which is impenetrable to the layman and as wide as it is complex. For this and other reasons radiation hazards are perceived to exceed all others and the public appear to have a poor image of the radiation protection specialists. Communication with the public and the media is widely recognized as a key pan of an emergency plan. This view is supported in the European Union which has sponsored the book on 'Radiation and Radiation Protection - a course for primary and secondary schools' which is described in this paper. The training of emergency teams includes the use of drills and exercises to maintain skills and can also be used to test the adequacy of plans. Every effort should be made to simulate the pressure on time and resources which would occur in a real event. Radiation emergencies are fortunately rare and so there is little practical experience of these events. The emergency worker must gain some radiation protection skills and must be able to use some technical language when communicating with specialist advisors. For this reason the European Union has sponsored the book 'Radiation Protection for Emergency Workers' which is also described in this paper. (author)

Development of a National Education and Training Data Standards Strategy and Implementation Plan. Cat. No. EDU 4

Science.gov (United States)

Australian Institute of Health and Welfare, 2015

2015-01-01

The Australian Institute of Health and Welfare developed a national data standards strategy and implementation plan to enhance the comparability, quality and coherence of information across the Australian education and training sectors, including early childhood education, school education, vocational education and training (VET) and higher…

Planning and management support for NPP personnel SAT-based training programmes. IAEA regional workshop. Working material

International Nuclear Information System (INIS)

1998-01-01

Within the European regional TC Project a workshop on Planning and Management Support for NPP Personnel SAT Based Training programmes was held at the Paks NPP Maintenance Training Centre in June 1998. It was organized jointly by IAEA and the Paks NPP. The objective of the workshop was to present the important experience gained by successful implementation of the IAEA Model Project on Strengthening Training for Safe Operation at Paks NPP as well as international experience in developing and carrying out the projects to upgrade NPP personnel training in particular maintenance training, and competence based Systematic Approach to Training (SAT). Twenty five participants from Armenia, Bulgaria, China, Czech republic, Hungary, Romania, Russia, Slovak Republic and Ukraine attended the workshop presenting and exchanging experiences in implementing NPP SAT-based training programmes

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 7: PEP logistics and training plan requirements

Science.gov (United States)

1979-01-01

Recommendations for logistics activities and logistics planning are presented based on the assumption that a system prime contractor will perform logistics functions to support all program hardware and will implement a logistics system to include the planning and provision of products and services to assure cost effective coverage of the following: maintainability; maintenance; spares and supply support; fuels; pressurants and fluids; operations and maintenance documentation training; preservation, packaging and packing; transportation and handling; storage; and logistics management information reporting. The training courses, manpower, materials, and training aids required will be identified and implemented in a training program.

Training Plan (M29 Revision)

Science.gov (United States)

Online Submission, 2008

2008-01-01

The objectives of training activities as stated in the DoW are: 1. to organize training within the project for the participants to learn to use the necessary tools; 2. to support training activities of the partners when they deliver and take in use the tools and practices during extended pilots. The approach with regards to the first point is that…

Nuclear manpower planning and personnel training

International Nuclear Information System (INIS)

Chen, J.H.

1984-01-01

Taiwan Power Company has established a nuclear manpower program to identify human resources, selection and recruitment of entry level engineers and technicians of Nuclear Energy Group. The methodology to estimate the future nuclear manpower demand of Taipower has been clearly described in this article. Also, the manpower program is being used as the bases for nuclear training program development. For safe, reliable and efficient operation of nuclear power plants, Taipower has established a systematic training program for nuclear power stations and headquarter personnel. The training program has been implemented in three stages with different patterns of training program. The first stage of nuclear training before 1975 was completed successfully. The second stage of nuclear training currently conducted since 1975 enlarges domestic training capability. The third stage of nuclear training with a long term training program is now under a systematic and compositive development effort

Assessing Changes in Job Behavior Due to Training: A Guide to the Participant Action Plan Approach.

Science.gov (United States)

Office of Personnel Management, Washington, DC.

This guide provides a brief introduction to the Participant Action Plan Approach (PAPA) and a user's handbook. Part I outlines five steps of PAPA which determine how job behavior is changed by training course or program participation. Part II, the manual, is arranged by the five steps of the PAPA approach. Planning for PAPA discusses making…

A High Intensity Interval Training (HIIT)-Based Running Plan Improves Athletic Performance by Improving Muscle Power.

Science.gov (United States)

García-Pinillos, Felipe; Cámara-Pérez, Jose C; Soto-Hermoso, Víctor M; Latorre-Román, Pedro Á

2017-01-01

García-Pinillos, F, Cámara-Pérez, JC, Soto-Hermoso, VM, and Latorre-Román, PÁ. A High Intensity Interval Training (HIIT)-based running plan improves athletic performance by improving muscle power. J Strength Cond Res 31(1): 146-153, 2017-This study aimed to examine the effect of a 5-week high-intensity intermittent training (HIIT)-based running plan on athletic performance and to compare the physiological and neuromuscular responses during a sprint-distance triathlon before and after the HIIT period. Thirteen triathletes were matched into 2 groups: the experimental group (EG) and the control group (CG). The CG was asked to maintain their normal training routines, whereas the EG maintained only their swimming and cycling routines and modified their running routine. Participants completed a sprint-distance triathlon before (pretest) and after (posttest) the intervention period. In both pretest and posttest, the participants performed 4 jumping tests: before the race (baseline), postswim, postcycling, and postrun. Additionally, heart rate was monitored (HRmean), whereas rate of perceived exertion (RPE) and blood lactate accumulation (BLa) were registered after the race. No significant differences (p ≥ 0.05) between groups were found before HIIT intervention (at pretest). Significant group-by-training interactions were found in vertical jumping ability and athletic performance: the EG improved jumping performance (∼6-9%, p ≤ 0.05, effect size (ES) > 0.7), swimming performance (p = 0.013, ES = 0.438), and running time (p = 0.001, ES = 0.667) during the competition, whereas the CG remained unchanged (p ≥ 0.05, ES HIIT-based running plan combined with the high training volumes of these triathletes in swimming and cycling improved athletic performance during a sprint-distance triathlon. This improvement may be due to improved neuromuscular characteristics that were transferred into improved muscle power and work economy.

Virtual reality in design, planning, operation and training related to the decommissioning of the Chernobyl NPP

International Nuclear Information System (INIS)

Mark, N.-K.; Johnsen, T.; Meyer, G.; Owre, F.

2007-01-01

Virtual Reality in refueling operation and maintenance training at Leningrad NPP has been recognized by Chernobyl NPP. Institute for Energy Technology's is establishing now the Chernobyl Decommissioning Visualization Centre to be used for planning and training the dismantling procedures in addition to presenting it to the authorities and the public. It will be ready in 2007. The first scenario will be the dismantling of the refueling machines

Is Participatory Action Research an innovative pedagogical alternative for training teachers as researchers? The training plan and evaluation for normal schools.

Science.gov (United States)

Paredes-Chi, Arely Anahy; Castillo-Burguete, María Teresa

2018-06-01

Normal schools in Mexico train teachers for basic level education. Classified as Higher Education Institutions, part of their mandate is to conduct scientific research to improve educational quality. Currently, normal school students can meet graduation requirements by either writing a thesis or reporting on professional practice using Participatory Action Research (PAR). Teachers at normal schools have only limited experience in conducting and supervising PAR projects. With the aim of analyzing the situation and addressing this paradox, we used PAR to develop a plan to train normal school teachers in application of PAR methodology. We present the training proposal and evaluate its results in a pilot phase. These suggest that PAR represents an innovative option for training teachers to conduct research and therefore fulfill part of their responsibilities at normal schools in Mexico. Changes in institutional culture and structure would be required for successful implementation of PAR in this context. Copyright © 2018 Elsevier Ltd. All rights reserved.

25 CFR 26.22 - May a tribe integrate Job Placement and Training funds into its Public Law 102-477 Plan?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false May a tribe integrate Job Placement and Training funds... THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.22 May a tribe integrate Job Placement and Training funds into its Public Law 102-477 Plan? Yes, Indian tribes...

5 CFR 724.203 - Training obligations.

Science.gov (United States)

2010-01-01

...) Each agency must develop a written plan to train all of its employees (including supervisors and... materials and method of its training plan. Each agency training plan shall describe: (1) The instructional materials and method of the training, (2) The training schedule, and (3) The means of documenting completion...

Project Management Plan/Progress Report UT/GTKS Training Program Development for Commercial Building Operators

Energy Technology Data Exchange (ETDEWEB)

None, None

2013-03-31

Universidad del Turabo (UT), in a collaborative effort with Global Turn Key Services, Inc. (GTKS), proposed to develop a training program and a commercialization plan for the development of Commercial Building Operators (CBOs). The CBOs will operate energy efficient buildings to help maintain existing buildings up to their optimal energy performance level, and ensure that net-zero-energy buildings continuously operate at design specifications, thus helping achieve progress towards meeting BTP Strategic Goals of creating technologies and design approaches that enable net-zero-energy buildings at low incremental costs by 2025. The proposed objectives were then: (1) Develop a Commercial Building Operator (CBO) training program and accreditation that will in turn provide a certification to participants recognized by Accreditation Boards such as the North American Board of Certified Energy Practitioners (NABCEP) and Leadership in Energy & Environmental Designs (LEED). (2) Develop and implement a commercialization and sustainability plan that details marketing, deployment, financial characterization, job placement, and other goals required for long-term sustainability of the project after the funding period. (3) After program development and deployment, provide potential candidates with the knowledge and skill sets to obtain employment in the commercial building green energy (net-zero-energy building) job market. The developed CBO training program will focus on providing skills for participants, such as displaced and unemployed workers, to enter the commercial building green energy (net-zeroenergy building) job market. This course was designed to allow a participant with minimal to no experience in commercial building green technology to obtain the required skill sets to enter the job market in as little as 12 weeks of intensive multi-faceted learning. After completion of the course, the CBO staff concluded the participant will meet minimum established accreditation

Army Task Force on Behavioral Health: Corrective Action Plan

Science.gov (United States)

2013-01-01

Veterans Affairs Legal Section KNOWLEDGE MGMT SECTION • KMO • CAA Analyst Figure I-1. Task Force Organization. ACRONYM Key ASA(M&RA): Assistant...Army Audit Agency OTIG: Office of the Inspector General OTSG: Office of the Surgeon General KMO : Knowledge Management Officer CAA: Center for

30 CFR 46.3 - Training plans.

Science.gov (United States)

2010-07-01

... Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND..., National Mine Health and Safety Academy, 1301 Airport Road, Beaver, WV 25813-9426, Telephone: (304) 256... responsible for the health and safety training at the mine. This person may be the production-operator or...

20 CFR 668.700 - What process must an INA grantee use to plan its employment and training services?

Science.gov (United States)

2010-04-01

... it uses to plan other activities and services. (b) However, in the process of preparing its Two Year... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What process must an INA grantee use to plan its employment and training services? 668.700 Section 668.700 Employees' Benefits EMPLOYMENT AND...

Table-top trainings in radiation protection. Educational element or emergency planning?

International Nuclear Information System (INIS)

Stolar, A.

2009-01-01

Education plays an important role in emergency management to prepare members of all levels of management for the worst case scenario. The mission that organizations have to deal with, is based on the application of fundamental knowledge, accumulated know-how and knowledge of the intersections and abilities of the participating organizations. An effective, safe and resource-saving way to get effective help in preparing disasters are table-top trainings. What great warlords helped to win centuries ago, is now increasingly anchored on a statutory basis and introduced in the emergency planning. (orig.)

A diagnostic study of Department of Health training courses for family planning providers.

Science.gov (United States)

Rood, S; Raquepo, M; Ladia, M A

1993-01-01

A study in the Philippines sought to observe and describe the family planning (FP) training program in two regions. This program trains physicians, nurses, and midwives as a team and includes a Basic/Comprehensive (B/C) course in FP with didactic and practicum elements, training in interpersonal communication skills (ICS) for those who have completed with B/C course, and a Preceptors Course for those who will supervise the practicum phase of the B/C course. The study gathered specific information on 1) trainee absenteeism and drop-out rates, 2) course content and effects, 3) the trainee selection process, 4) the practicum requirement for the B/C course, and 5) service delivery values and quality of care. Data were collected through observations, questionnaires, exit interviews with clients during the practicum phase, interviews with supervisors and public officials (mayors), and focus group discussions with regional trainers. This assessment led to the following recommendations: 1) maintain the current team approach; 2) reserve basic orientation-type subjects for office-based training to allow more time for FP topics in the training programs; 3) use caution in making a switch to "competency-based" training because of the possibility that supervision is inadequate for such a training method; 4) improve scheduling; 5) enforce the prerequisites for participation in the ICS and Preceptors Courses; 6) assign only one trainee to a preceptor area during the practicum and reduce the quota of IUD insertions to reduce pressure to obtain IUD acceptors; 7) create a "model" FP clinic each time a preceptor is trained; 8) pay more attention to natural FP methods; and 9) maintain an emphasis on quality of care.

[Progress and Future of the Training Plan for Cancer Professionals - Looking Back for 10 Years].

Science.gov (United States)

Matsuura, Nariaki

2017-06-01

In order to increase cancer professionals in Japan, the first phase of training plan for cancer professionals was performed for 5 years from 2007t o 2011, and the second one was performed for 5 years from 2012 to 2016. 95 universities for 18 hubs in the first phase and 100 universities for 15 hubs in the second one participated in this project 2,590 graduate students in the first phase and 2,319 students for 3 years in the second phase learned. Although the number of cancer professionals increased after the start of this project, it is still half of the set points and more efforts are required for this project. From 2017, the new training plan for cancer professionals will start for the third phase, and various professionals such as genome medicine professionals, rare cancer professionals, pediatric cancer professionals and those for the life-stage problems in cancer patients will be educated.

Irrigation Training Manual. Planning, Design, Operation, and Management of Small-Scale Irrigation Systems [and] Irrigation Reference Manual. A Technical Reference to Be Used with the Peace Corps Irrigation Training Manual T0076 in the Selection, Planning, Design, Operation, and Management of Small-Scale Irrigation Systems.

Science.gov (United States)

Salazar, LeRoy; And Others

This resource for trainers involved in irrigated agriculture training for Peace Corps volunteers consists of two parts: irrigation training manual and irrigation reference manual. The complete course should fully prepare volunteers serving as irrigation, specialists to plan, implement, evaluate and manage small-scale irrigation projects in arid,…

Application of Multiple-Population Genetic Algorithm in Optimizing the Train-Set Circulation Plan Problem

Directory of Open Access Journals (Sweden)

Yu Zhou

2017-01-01

Full Text Available The train-set circulation plan problem (TCPP belongs to the rolling stock scheduling (RSS problem and is similar to the aircraft routing problem (ARP in airline operations and the vehicle routing problem (VRP in the logistics field. However, TCPP involves additional complexity due to the maintenance constraint of train-sets: train-sets must conduct maintenance tasks after running for a certain time and distance. The TCPP is nondeterministic polynomial hard (NP-hard. There is no available algorithm that can obtain the optimal global solution, and many factors such as the utilization mode and the maintenance mode impact the solution of the TCPP. This paper proposes a train-set circulation optimization model to minimize the total connection time and maintenance costs and describes the design of an efficient multiple-population genetic algorithm (MPGA to solve this model. A realistic high-speed railway (HSR case is selected to verify our model and algorithm, and, then, a comparison of different algorithms is carried out. Furthermore, a new maintenance mode is proposed, and related implementation requirements are discussed.

Academic Training: Academic Training Lectures-Questionnaire

CERN Multimedia

2004-01-01

ACADEMIC TRAINING Françoise Benz tel. 73127 academic.training@cern.ch SUGGEST AND WIN! Its time to plan the 2004-2005 lecture series. From today until March 19 you have the chance to give your contribution to planning for next year's Academic Training Lecture Series. At the web site: http://cern.ch/Academic.Training/questionnaire you will find questionnaires proposing topics in high energy physics, applied physics and science and society. Answering the questionnaire will help ensure that the selected topics are as close as possible to your interests. In particular requests and comments from students will be much appreciated. To encourage your contribution, the AT Committee will reward one lucky winner with a small prize, a 50 CHF coupon for a book purchase at the CERN bookshop.

Training Accreditation Program

International Nuclear Information System (INIS)

1989-01-01

The Training Accreditation Program establishes the objectives and criteria against which DOE nuclear facility training is evaluated to determine its readiness for accreditation. Training programs are evaluated against the accreditation objectives and criteria by facility personnel during the initial self-evaluation process. From this self-evaluation, action plans are made by the contractor to address the scope of work necessary in order to upgrade any deficiencies noted. This scope of work must be formally documented in the Training Program Accreditation Plan. When reviewed and approved by the responsible Head of the Field Organization and cognizant Program Secretarial Office, EH-1 concurrence is obtained. This plan then becomes the document which guides accreditation efforts for the contractor

Patient-specific cardiac phantom for clinical training and preprocedure surgical planning.

Science.gov (United States)

Laing, Justin; Moore, John; Vassallo, Reid; Bainbridge, Daniel; Drangova, Maria; Peters, Terry

2018-04-01

Minimally invasive mitral valve repair procedures including MitraClip ® are becoming increasingly common. For cases of complex or diseased anatomy, clinicians may benefit from using a patient-specific cardiac phantom for training, surgical planning, and the validation of devices or techniques. An imaging compatible cardiac phantom was developed to simulate a MitraClip ® procedure. The phantom contained a patient-specific cardiac model manufactured using tissue mimicking materials. To evaluate accuracy, the patient-specific model was imaged using computed tomography (CT), segmented, and the resulting point cloud dataset was compared using absolute distance to the original patient data. The result, when comparing the molded model point cloud to the original dataset, resulted in a maximum Euclidean distance error of 7.7 mm, an average error of 0.98 mm, and a standard deviation of 0.91 mm. The phantom was validated using a MitraClip ® device to ensure anatomical features and tools are identifiable under image guidance. Patient-specific cardiac phantoms may allow for surgical complications to be accounted for preoperative planning. The information gained by clinicians involved in planning and performing the procedure should lead to shorter procedural times and better outcomes for patients.

Web-Based Training on Reviewing Dose Modeling Aspects of NRC Decommissioning and License Termination Plans

International Nuclear Information System (INIS)

LePoire, D.; Cheng, J.J.; Kamboj, S.; Arnish, J.; Richmond, P.; Chen, S.Y.; Barr, C.; McKenney, C.

2008-01-01

NRC licensees at decommissioning nuclear facilities submit License Termination Plans (LTP) or Decommissioning Plans (DP) to NRC for review and approval. To facilitate a uniform and consistent review of these plans, the NRC developed training for its staff. A live classroom course was first developed in 2005, which targeted specific aspects of the LTP and DP review process related to dose-based compliance demonstrations or modeling. A web-based training (WBT) course was developed in 2006 and 2007 to replace the classroom-based course. The advantage of the WBT is that it will allow for staff training or refreshers at any time, while the advantage of a classroom-based course is that it provides a forum for lively discussion and the sharing of experience of classroom participants. The objective of this course is to train NRC headquarters and regional office staff on how to review sections of a licensee's DP or LTP that pertain to dose modeling. The DP generally refers to the decommissioning of non-reactor facilities, while the LTP refers specifically to the decommissioning of reactors. This review is part of the NRC's licensing process, in which the NRC determines if a licensee has provided a suitable technical basis to support derived concentration guideline levels (DCGLs)1 or dose modeling analyses performed to demonstrate compliance with dose-based license termination rule criteria. This type of training is one component of an organizational management system. These systems 'use a range of practices to identify, create, represent, and distribute knowledge for reuse, awareness and learning'. This is especially important in an organization undergoing rapid change or staff turnover to retain organizational information and processes. NRC is committed to maintaining a dynamic program of training, development, and knowledge transfer to ensure that the NRC acquires and maintains the competencies needed to accomplish its mission. This paper discusses one specific project

External plans for radiological emergency; Plan de emergencia radiologica externo

Energy Technology Data Exchange (ETDEWEB)

Suarez, G; Vizuet G, J; Benitez S, J A [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

1999-07-01

Since 1989, the National Institute of Nuclear Research in Mexico shares in the task of Food and Water Control corresponding to the FT-86 task force of External Plans for Radiological Emergency (PERE), in charge of the Veracruz Health Services. In the PERE preparation stage previous actions are necessary developed for the preparation and updating of this plan and the task organization with the purpose to maintaining standing and operable in any time and circumstance, the capability to response in the face of an emergency. This stage englobes activities which must be realized before to carry out the Plan as they are the specialized training of personnel which participates and the execution of exercises and simulacrums. Until 1998, training and exercises for this task had been realized under diverse possible sceneries but in conditions that simulated the presence of radioactive material. For this reason, it should be emphasized the training realized during the days 6th, 7th, 8th July, 1999, in the emergency planning zone of the Plan, which to carry out using radioactive material. The National Institute of Nuclear Research had in charge of the training. This work describes all the activities for the realization of this training. (Author)

"Giving us hope": Parent and neonatal staff views and expectations of a planned family-centred discharge process (Train-to-Home).

Science.gov (United States)

Ingram, Jenny; Redshaw, Maggie; Manns, Sarah; Beasant, Lucy; Johnson, Debbie; Fleming, Peter; Pontin, David

2017-08-01

Preparing families and preterm infants for discharge is relatively unstructured in many UK neonatal units (NNUs). Family-centred neonatal care and discharge planning are recommended but variable. Qualitative interviews with 37 parents of infants in NNUs, and 18 nursing staff and 5 neonatal consultants explored their views of discharge planning and perceptions of a planned family-centred discharge process (Train-to-Home). Train-to-Home facilitates communication between staff and parents throughout the neonatal stay, using a laminated train and parent booklets. Parents were overwhelmingly positive about Train-to-Home. They described being given hope, feeling in control and having something visual to show their baby's progress. They reported positive involvement of fathers and families, how predicted discharge dates helped them prepare for home and ways staff engaged with Train-to-Home when communicating with them. Nursing staff reactions were mixed-some were uncertain about when to use it, but found the visual images powerful. Medical staff in all NNUs were positive about the intervention recognizing that it helped in communicating better with parents. Using a parent-centred approach to communication and informing parents about the needs and progress of their preterm infant in hospital is welcomed by parents and many staff. This approach meets the recommended prioritization of family-centred care for such families. Predicted discharge dates helped parents prepare for home, and the ways staff engaged with Train-to-Home when communicating with them helped them feel more confident as well as having something visual to show their baby's progress. © 2016 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

MODALITIES OF TRAINING PARAMETER ALTERNATION IN NOWADAYS STRENGTH TRAINING PRACTICE

Directory of Open Access Journals (Sweden)

RANISAVLJEV IGOR

2010-12-01

Full Text Available Large number of variables could be alternated during the process of planning and programming in sports training. Superior training results in majority of sports are achieved by optimally manipulating training parameters in appropriate sequences and combinations. Additionally, in some sports they might be the result of appropriate periodization pattern. Today's tendency in strength training practice is training movements instead of training muscles. Exercise classification according to the dominant movement types, allows creating new modalities in training alternation. Additional variations in volume, intensity, rest brakes, repetition velocity andinter-repetition rest can be the important part of functional strength training program. Alternation and combination of different training parameters makes appropriate training stimulus for strength increase in the most of nowadays sports. Optimal alternation of basic training parameters should be the first part in the processof planning and programming. As a result, majority of athletes might not need advanced periodization patterns for optimal improvement in muscle strength and power

Optimizing Preseason Training Loads in Australian Football.

Science.gov (United States)

Carey, David L; Crow, Justin; Ong, Kok-Leong; Blanch, Peter; Morris, Meg E; Dascombe, Ben J; Crossley, Kay M

2018-02-01

To investigate whether preseason training plans for Australian football can be computer generated using current training-load guidelines to optimize injury-risk reduction and performance improvement. A constrained optimization problem was defined for daily total and sprint distance, using the preseason schedule of an elite Australian football team as a template. Maximizing total training volume and maximizing Banister-model-projected performance were both considered optimization objectives. Cumulative workload and acute:chronic workload-ratio constraints were placed on training programs to reflect current guidelines on relative and absolute training loads for injury-risk reduction. Optimization software was then used to generate preseason training plans. The optimization framework was able to generate training plans that satisfied relative and absolute workload constraints. Increasing the off-season chronic training loads enabled the optimization algorithm to prescribe higher amounts of "safe" training and attain higher projected performance levels. Simulations showed that using a Banister-model objective led to plans that included a taper in training load prior to competition to minimize fatigue and maximize projected performance. In contrast, when the objective was to maximize total training volume, more frequent training was prescribed to accumulate as much load as possible. Feasible training plans that maximize projected performance and satisfy injury-risk constraints can be automatically generated by an optimization problem for Australian football. The optimization methods allow for individualized training-plan design and the ability to adapt to changing training objectives and different training-load metrics.

Controllability of Train Service Network

Directory of Open Access Journals (Sweden)

Xuelei Meng

2015-01-01

Full Text Available Train service network is a network form of train service plan. The controllability of the train service plan determines the recovery possibility of the train service plan in emergencies. We first build the small-world model for train service network and analyze the scale-free character of it. Then based on the linear network controllability theory, we discuss the LB model adaptability in train service network controllability analysis. The LB model is improved and we construct the train service network and define the connotation of the driver nodes based on the immune propagation and cascading failure in the train service network. An algorithm to search for the driver nodes, turning the train service network into a bipartite graph, is proposed and applied in the train service network. We analyze the controllability of the train service network of China with the method and the results of the computing case prove the feasibility of it.

Planning and assessing a cross-training initiative with multi-skilled employees.

Science.gov (United States)

Wermers, M A; Dagnillo, R; Glenn, R; Macfarlane, R; St Clair, V; Scott, D

1996-06-01

An improvement initiative begun by nurses at Parkview Episcopal Medical Center (Pueblo, Colo) to develop patient-focused care delivered by multiskilled workers followed a quality improvement methodology. Implementation of the new care delivery system on a model unit--2 South--provided the opportunity to plan, analyze data, and make changes as appropriate. Parkview's indoctrination of the teachings of W. Edwards Deming has helped leaders and staff realize the integral role of training in improvement activities. In his 14 points, Deming emphasizes the importance of employee education and of the employee having a clear understanding of his or her job. The time and money put into up-front education should help ensure the long-term success of this initiative. DEFINING THE CAREPARTNER: Three new multi-skilled positions were developed on 2 South--a Personal CarePartner, a Business CarePartner, and a Clinical CarePartner. By cross-training each of these roles to perform duties formerly done by centralized departments, 2 South was able to cut costs and time while ensuring quality care. TRAINING THE CAREPARTNER: An internally developed training program provided the new CarePartners with up-front education to prepare them to deliver patient-centered care. 2 South has experienced drops in patient falls and medication errors--areas that are often negatively affected when multi-skilled programs are instituted. Patient and physician surveys have shown increased satisfaction with care provided on the unit. The increased efficiency of the model unit has produced these outcomes while cutting costs substantially. The interdisciplinary team coordinating the improvement project learned many lessons in the process, including the importance of communication, education, and a sense of humor.

Sable Offshore Energy Inc.: Response to 'The Canada-Nova Scotia Offshore Petroleum Board Benefits Plan Decision Report' Condition No. 3: Employment and Training Plan; Condition No. 4: Research and Development Plan; Condition No. 6: Disadvantaged Individual or Groups; Condition No. 7: Technology Transfer

International Nuclear Information System (INIS)

1998-01-01

Decisions of the Canada-Nova Scotia Offshore Petroleum Board, regarding the responses of Sable Offshore Energy Inc (SOEI) to conditions imposed by the Board in the Sable Offshore Energy Project Canada-Nova Scotia Benefit Plan Decision Report, have been announced. According to the press release (copy attached), the Board accepted the responses of SOEI regarding the establishment and staffing of an office in Nova Scotia for the implementation and project management and training of project personnel, the level of expenditures for research and development to be undertaken in Nova Scotia, proposed initiatives for employment and training opportunities for disadvantaged individuals and groups, and a technology transfer plan that will facilitate succession planning and create joint venturing opportunities for Nova Scotian and Canadian industry. tabs., figs

Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.

Science.gov (United States)

Cai, Shanbao; Xu, Yi; Cooper, Ryan J; Ferkowicz, Michael J; Hartwell, Jennifer R; Pollok, Karen E; Kelley, Mark R

2005-04-15

DNA repair capacity of eukaryotic cells has been studied extensively in recent years. Mammalian cells have been engineered to overexpress recombinant nuclear DNA repair proteins from ectopic genes to assess the impact of increased DNA repair capacity on genome stability. This approach has been used in this study to specifically target O(6)-methylguanine DNA methyltransferase (MGMT) to the mitochondria and examine its impact on cell survival after exposure to DNA alkylating agents. Survival of human hematopoietic cell lines and primary hematopoietic CD34(+) committed progenitor cells was monitored because the baseline repair capacity for alkylation-induced DNA damage is typically low due to insufficient expression of MGMT. Increased DNA repair capacity was observed when K562 cells were transfected with nuclear-targeted MGMT (nucl-MGMT) or mitochondrial-targeted MGMT (mito-MGMT). Furthermore, overexpression of mito-MGMT provided greater resistance to cell killing by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) than overexpression of nucl-MGMT. Simultaneous overexpression of mito-MGMT and nucl-MGMT did not enhance the resistance provided by mito-MGMT alone. Overexpression of either mito-MGMT or nucl-MGMT also conferred a similar level of resistance to methyl methanesulfonate (MMS) and temozolomide (TMZ) but simultaneous overexpression in both cellular compartments was neither additive nor synergistic. When human CD34(+) cells were infected with oncoretroviral vectors that targeted O(6)-benzylguanine (6BG)-resistant MGMT (MGMT(P140K)) to the nucleus or the mitochondria, committed progenitors derived from infected cells were resistant to 6BG/BCNU or 6BG/TMZ. These studies indicate that mitochondrial or nuclear targeting of MGMT protects hematopoietic cells against cell killing by BCNU, TMZ, and MMS, which is consistent with the possibility that mitochondrial DNA damage and nuclear DNA damage contribute equally to alkylating agent-induced cell killing during chemotherapy.

O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.

Science.gov (United States)

Raj, Nitya; Klimstra, David S; Horvat, Natally; Zhang, Liying; Chou, Joanne F; Capanu, Marinela; Basturk, Olca; Do, Richard Kinh Gian; Allen, Peter J; Reidy-Lagunes, Diane

2017-07-01

Alkylating agents have activity in well-differentiated pancreatic neuroendocrine tumors (WD panNETs). In glioblastoma multiforme, decreased activity of O-methylguanine DNA methyltransferase (MGMT) predicts response; in panNETs, MGMT relevance is unknown. We identified patients with WD panNETs treated with alkylating agents, determined best overall response by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1, and performed MGMT activity testing. Fifty-six patients were identified; 26 (46%) of the 56 patients experienced partial response, 24 (43%) of 56 experienced stable disease, and 6 (11%) of 56 experienced progression of disease. O-methylguanine DNA methyltransferase status was available for 36 tumors. For tumors with partial response, 10 (67%) of 15 were MGMT deficient, and 5 (33%) of 15 were MGMT intact. For tumors with stable disease, 7 (47%) of 15 were MGMT deficient, and 8 (53%) of 15 were MGMT intact. For tumors with progression of disease, 3 (50%) of 6 were MGMT deficient, and 3 (50%) of 6 were MGMT intact. We observed response and resistance to alkylating agents in MGMT-deficient and MGMT-intact tumors. O-methylguanine DNA methyltransferase status should not guide alkylating agent therapy in WD panNETs.

Features of account and planning of training process of sportsmen pair-group acrobats taking into account sexual dimorphism (analysis of questionnaire these trainers of Ukraine

Directory of Open Access Journals (Sweden)

N.V. Bachinskaya

2015-01-01

Full Text Available Purpose: expose the features of planning of training process of different age acrobats and line of business on the stage of the direct training to the competitions from position of sexual dimorphism. Research tasks was to define methods and criteria of account and control of the training loading in pair-group to acrobatics. Material: in a questionnaire took part 38 trainers of Ukraine on sporting acrobatics aged from 28 to 68 years. Results: it is set that in an incomplete measure registered trainers loading executed sportsmen. The insufficient disinformation of trainers is exposed about knowledge and necessity of account of gender distinctions. Also about the methods of realization of account of the specific loading. There is absence of model of account, planning and control of the trainings loadings taking into account the functional, age, sexual features of sportsmen depending on their line of business. Conclusions: findings testify to the necessity of perfection of existent method of planning of training process. It is necessary to probe the morphofunctional features of organism of sportsmen and sportswomen. Also - to take into account the features of sexual dimorphism depending on the specific of type of sport. It is necessary to develop the trainings programs from position of morphofunctional and adaptation distinctions of masculine and womanish organism.

The Planning Process in Managing Organisations of Continuing Education: The Case of Greek Vocational Training Institutions

Science.gov (United States)

Petridou, Eugenia; Chatzipanagiotou, Paraskevi

2004-01-01

The aim of this article is to offer a framework model of the planning of the activities of organisations of continuing education and training, which gives the opportunity to determine their mission, to seek specific aims, to develop the available resources and to create a cooperative operating climate. Adopting this recommended model would help…

Compression planning for continuous improvement in quality programs

International Nuclear Information System (INIS)

Willis, Y.A.; Hood, F.C.

1992-01-01

This paper describes Compression Planning, an innovative approach for planning in groups. This participative and structured approach is especially suitable for technical and highly regulated organizations. Compression Planning was applied to the first organization-wide effort at training integration for regulatory compliance, at Battelle Pacific Northwest Laboratory (PNL), a multi-program national laboratory. The planning process was judged as measurably superior to PNL's customary planning. Within 10 days a training policy was issued and an action plan drafted. The participants produced a report identifying and prioritizing 33 key training issues; began to data gather and solicit input from personnel Lab-wide, producing a 2-volume training inventory; and formulated 14 recommendations for implementation. Two years later the plan is still evolving, as PNL training continues to develop, consistent with Continuous Improvement Process objectives

Strategic Planning and Online Learning

Science.gov (United States)

McLaughlin-Graham, Karen; Berge, Zane L.

2005-01-01

Strategic planning is a critical part of sustaining distance education. Through such planning, the organization can solve business problems that involve training and education in an effective and often cost savings manner compared to in-person training efforts. This paper examines the strategic planning process as it relates to sustaining distance…

Expression profiling of O6 methylguanine-DNA-methyl transferase in prolactinomas: a correlative study of promoter methylation and pathological features in 136 cases

International Nuclear Information System (INIS)

Jiang, Xiao-Bing; Hu, Bin; He, Dong-Sheng; Mao, Zhi-Gang; Wang, Xin; Song, Bing-Bing; Zhu, Yong-Hong; Wang, Hai-Jun

2015-01-01

Low-level expression of O 6 methylguanine-DNA-methyl transferase (MGMT) prolactinomas has been noted previously in case reports, although what modulates MGMT expression remains unclear. This study therefore aimed to delineate the factors regulating MGMT expression in prolactinomas. We retrospectively reviewed 136 prolactinoma patients who were treated in our center between January 2000 and September 2013. Expression of MGMT, Ki-67, and p53 protein were examined by immunohistochemical staining, and MGMT promoter methylation evaluated with methylation-specific PCR. MGMT immunopositivity was <25 % in 106/136 tumor specimens (77.94 %). MGMT immunoexpression was positively correlated with age (r = 0.251, p = 0.003), but inversely correlated with p53 staining (r = −0.153, p = 0.021). Moreover, reduced MGMT expression was more frequent in atypical prolactinomas (p = 0.044). Methylated MGMT promoter was confirmed in 10/46 specimens (21.7 %), all of which had low level or absent MGMT staining. Both p53 protein (r = −0.33, p = 0.025) and promoter methylation (r = −0.331, p = 0.025) were negatively associated with MGMT expression. Multivariate logistic analysis indicated that age (odds ratio [OR] = 1.127. 95 % confidence interval [CI] 1.027–1.236, p = 0.012) and p53 (OR = 0.116. 95 % CI 0.018–0.761, p = 0.025) staining were independent determents of MGMT expression. The majority of prolactinomas, especially atypical prolactinomas, showed low-level or no MGMT immunoexpression, providing a rationale for the utility of temozolomide as an alternative to managing prolactinomas. In summary, epigenetic and transcriptional regulation are involved in silencing MGMT expression

Integration of a physical training program in a weight loss plan for overweight pet dogs.

Science.gov (United States)

Vitger, Anne D; Stallknecht, Bente M; Nielsen, Dorte H; Bjornvad, Charlotte R

2016-01-15

To investigate whether a controlled physical training plan for overweight dogs during a weight loss program would improve cardiorespiratory fitness and better preserve lean body mass, compared with results for dogs undergoing a weight loss program based on caloric restriction alone. Prospective, nonrandomized clinical study. 19 client-owned overweight or obese dogs. All dogs were fed the same calorie-restricted diet rationed to achieve a weight loss rate of 1% to 2%/wk for 12 weeks. The fitness-and-diet (FD) group participated in a training program that included underwater and land-based treadmill exercise 3 times/wk. The diet-only (DO) group had no change in exercise routines. Daily activity before and during the intervention was recorded by accelerometry. Before and after intervention, heart rate during exercise was recorded to assess cardiovascular fitness, and body composition was analyzed by dual-energy x-ray absorptiometry. Differences between groups were evaluated with t tests and multiple regression analysis. Mean weight loss was 13.9% and 12.9% for the FD and DO groups, respectively (n = 8 dogs/group that completed the study). Mean accelerometer counts during intervention were 13% higher than baseline counts for the FD group. Heart rate during exercise declined after intervention in both groups. Lean body mass was preserved in the FD group and lost in the DO group during intervention. The controlled exercise plan used with a dietary weight loss program prevented loss of lean body mass in dogs. This finding supports inclusion of controlled physical training for obesity management in dogs.

The Challenge of Change. National Printing Industry Training Council Training Plan.

Science.gov (United States)

Cesnich, J.; And Others

Principally concerned with printing, publishing, and paper and paper products, the Australian printing industry is segmented into two sectors: general production and specialist (concerned with a variety of processes and products.) Current arrangements for entry-level training in the industry generally consist of off-the-job training usually…

Impact of Family Planning and Business Trainings on Private-Sector Health Care Providers in Nigeria.

Science.gov (United States)

Ugaz, Jorge; Leegwater, Anthony; Chatterji, Minki; Johnson, Doug; Baruwa, Sikiru; Toriola, Modupe; Kinnan, Cynthia

2017-06-01

Private health care providers are an important source of modern contraceptives in Sub-Saharan Africa, yet they face many challenges that might be addressed through targeted training. This study measures the impact of a package of trainings and supportive supervision activities targeted to private health care providers in Lagos State, Nigeria, on outcomes including range of contraceptive methods offered, providers' knowledge and quality of counseling, recordkeeping practices, access to credit and revenue. A total of 965 health care facilities were randomly assigned to treatment and control groups. Facilities in the treatment group-but not those in the control group-were offered a training package that included a contraceptive technology update and interventions to improve counseling and clinical skills and business practices. Multivariate regression analysis of data collected through facility and mystery client surveys was used to estimate effects. The training program had a positive effect on the range of contraceptive methods offered, with facilities in the treatment group providing more methods than facilities in the control group. The training program also had a positive impact on the quality of counseling services, especially on the range of contraceptive methods discussed by providers, their interpersonal skills and overall knowledge. Facilities in the treatment group were more likely than facilities in the control group to have good recordkeeping practices and to have obtained loans. No effect was found on revenue generation. Targeted training programs can be effective tools to improve the provision of family planning services through private providers.

Measuring the usefulness of family planning job aids following distribution at training workshops.

Science.gov (United States)

Tumlinson, Katherine; Hubacher, David; Wesson, Jennifer; Lasway, Christine

2010-09-01

A job aid is a tool, such as a flowchart or checklist, that makes it easier for staff to carry out tasks by providing quick access to needed information. Many public health organizations are engaged in the production of job aids intended to improve adherence to important medical guidelines and protocols, particularly in resource-constrained countries. However, some evidence suggests that actual use of job aids remains low. One strategy for improving utilization is the introduction of job aids in training workshops. This paper summarizes the results of two separate evaluations conducted in Uganda and the Dominican Republic (DR) which measured the usefulness of a series of four family planning checklists 7-24 months after distribution in training workshops. While more than half of the health care providers used the checklists at least once, utilization rates were sub-optimal. However, the vast majority of those providers who utilized the checklists found them to be very useful in their work.

Questionnaire for the contents of cancer professional training plan by Ministry of Education, Culture, Sports, Science, and Technology Japan

International Nuclear Information System (INIS)

Sasaki, Ryohei; Numasaki, Hodaka; Teshima, Teruki; Nishio, Teiji; Fukuda, Haruyuki; Ashino, Yasuo; Onishi, Hiroshi; Nakamura, Katsumasa; Nagata, Yasushi

2009-01-01

Questionnaire for the contents of cancer professional training plan by Ministry of Education, Culture, Sports, Science, and Technology Japan were widely assessed and introduced in the 4th Japanese Society for Therapeutic Radiology and Oncology (JASTRO) Future Planning Seminar held on March 8, 2008 in Tokyo, Japan. From the assessment, small number of instructors for medical physicists was elucidated as the most important problem for the future of fields of radiation oncology in Japan. (author)

Daybreak - a corporation plan of development and capacitation; Amanecer - un plan corporativo de desarollo y capacitacion

Energy Technology Data Exchange (ETDEWEB)

Pellegrini, Enzo [REPSOL Yacimientos Petroliferos Fiscales S.A. (Argentina)

2000-07-01

The current growth in production investments is motivating a war for talent which demands from companies a serious compromise to the recruiting of personnel as well as development and training policies that will build: technical competencies related to teamwork; high tech tools and knowledge; general training that will nourish employability in an increasingly competitive environment. Repsol YPF Group, within its Corporate Plan for Development and Training, implemented Plan Amanecer. Following is a general outline of the Plan. (author)

National Training Course. Emergency Medical Technician. Paramedic. Instructor's Lesson Plans. Module II. Human Systems and Patient Assessment.

Science.gov (United States)

National Highway Traffic Safety Administration (DOT), Washington, DC.

This instructor's lesson plan guide on human systems and patient assessment is one of fifteen modules designed for use in the training of emergency medical technicians (paramedics). Four units are presented: (1) medical terminology, which covers some common prefixes and suffixes and the use of the medical dictionary; (2) an overview of the…

Training of nonlicensed personnel

International Nuclear Information System (INIS)

Hetrick, D.E.

1975-01-01

The safety and efficiency with which a station operates is a function of the competence and proficiency of all personnel. This includes the nonlicensed personnel who make up the bulk of the station staff. Thus the training of these members of the station complement is an important function in overall station performance. Standards, regulations, regulatory guides, and codes provide guidance to the training requirements for such personnel. Training needs and objectives must be established, a plan prepared and then all incorporated into a training program. A well planned and operated training program will stimulate effective communications between the different groups within the station and between the station and off site support groups

Transmit Power Minimization and Base Station Planning for High-Speed Trains with Multiple Moving Relays in OFDMA Systems

KAUST Repository

Ghazzai, Hakim

2016-03-15

High-speed railway system equipped with moving relay stations placed on the middle of the ceiling of each train wagon is investigated. The users inside the train are served in two hops via the orthogonal frequency-division multiple access (OFDMA) technology. In this work, we first focus on minimizing the total downlink power consumption of the base station (BS) and the moving relays while respecting specific quality of service (QoS) constraints. We first derive the optimal resource allocation solution in terms of OFDMA subcarriers and power allocation using the dual decomposition method. Then, we propose an efficient algorithm based on the Hungarian method in order to find a suboptimal but low complexity solution. Moreover, we propose an OFDMA planning solution for high-speed train by finding the maximal inter-BS distance given the required user data rates in order to perform seamless handover. Our simulation results illustrate the performance of the proposed resource allocation schemes in the case of the 3GPP Long Term Evolution-Advanced (LTE-A) and compare them with previously developed algorithms as well as with the direct transmission scenario. Our results also highlight the significant planning gain obtained thanks to the use of multiple relays instead of the conventional single relay scenario.

Evaluation of the toxicity of organic matter in marine sediments

Digital Repository Service at National Institute of Oceanography (India)

Sarkar, A.

stream_size 3 stream_content_type text/plain stream_name 2_Int_Conf_Waste_Mgmt_Chem_Petrochem_Ind_Toxic_Mgmt_1991_258.pdf.txt stream_source_info 2_Int_Conf_Waste_Mgmt_Chem_Petrochem_Ind_Toxic_Mgmt_1991_258.pdf.txt Content...

Management Training in Retailing.

Science.gov (United States)

Veness, C. Rosina

Intended for prospective members of the new Distributive Industrial Training Board in Great Britain, this training guide concentrates on managerial functions in retailing; the selection of trainees; the planning of in-company and external training programs; scheduling and continuity of training; roles of training personnel; and the use of various…

Medical workforce education and training: A failed decentralisation attempt to reform organisation, financing, and planning in England.

Science.gov (United States)

Ovseiko, Pavel V; Buchan, Alastair M

2015-12-01

The 2010-2015 Conservative and Liberal Democrat coalition government proposed introducing a radical decentralisation reform of the organisation, financing, and planning of medical workforce education and training in England. However, following public deliberation and parliamentary scrutiny of the government's proposals, it had to abandon and alter its original proposals to the extent that they failed to achieve their original decentralisation objectives. This failed decentralisation attempt provides important lessons about the policy process and content of both workforce governance and health system reforms in Europe and beyond. The organisation, financing, and planning of medical workforce education is as an issue of national importance and should remain in the stewardship of the national government. Future reform efforts seeking to enhance the skills of the workforce needed to deliver high-quality care for patients in the 21st century will have a greater chance of succeeding if they are clearly articulated through engagement with stakeholders, and focus on the delivery of undergraduate and postgraduate multi-professional education and training in universities and teaching hospitals. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

20 CFR 632.255 - Program planning.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Program planning. 632.255 Section 632.255... EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.255 Program planning. (a... with its title IV program. (2) Native American grantees shall use the planning process described in...

Report of the Regional Intensive Training Course on Education and Human Resources Planning (Damascus, Syrian Arab Republic, November 17 to December 12, 1979).

Science.gov (United States)

Caillods, Francoise; Hajjar, Habib

To train 19 participants from nine Arab governments in educational and human resources planning, an intensive four-week course was offered covering the use of population census data, assessment of economies' demands for education and training, and techniques of evaluation and of manpower forecasting. This report describes the organizing and…

The C's of Our Sea Change: Plans for Training Staff, from Core Competencies to Learning 2.0

Science.gov (United States)

Blowers, Helene; Reed, Lori

2007-01-01

This article explains a two-part plan, created by the people at the Public Library of Charlotte & Mecklenburg County (PLCMC), to help staff members keep up with the sea change of technology. A core competencies training program was developed. This keeps workers afloat by providing them with the technology skills they need to support the change…

Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link".

Science.gov (United States)

Oh, H K; Teo, A K; Ali, R B; Lim, A; Ayi, T C; Yarosh, D B; Li, B F

1996-09-24

Human O6-methylguanine-DNA methyltransferase (MGMT) repairs DNA by transferring alkyl (R-) adducts from O6-alkylguanine (6RG) in DNA to its own cysteine residue at codon 145 (formation of R-MGMT). We show here that R-MGMT in cell extracts, which is sensitive to protease V8 cleavage at the glutamic acid residues at codons 30 (E30) and 172 (E172), can be specifically immunoprecipitated with an MGMT monoclonal antibody, Mab.3C7. This Mab recognizes an epitope of human MGMT including the lysine 107 (K107) which is within the most basic region that is highly conserved among mammalian MGMTs. Surprisingly, the K107L mutant protein is repair-deficient and readily cleaved by protease V8 similar to R-MGMT. We propose that R-MGMT adopted an altered conformation which exposed the Mab.3C7 epitope and rendered that protein sensitive to protease V8 attack. This proposal could be explained by the disruption of a structural "salt-link" within the molecule based on the available structural and biochemical data. The specific binding of Mab.3C7 to R-MGMT has been compared with the protease V8 method in the detection of R-MGMT in extracts of cells treated with low dosages of methyliodide (SN2) and O6-benzylguanine. Their identical behaviors in producing protease V8 sensitive R-MGMT and Mab.3C7 immunoprecipitates suggest that probably methyl iodide (an ineffective agent in producing 6RG in DNA) can directly alkylate the active site of cellular MGMT similar to O6-benzylguanine. The effectiveness of MeI in producing R-MGMT, i.e., inactivation of cellular MGMT, indicates that this agent can increase the effectiveness of environmental and endogenously produced alkylating carcinogens in producing the mutagenic O6-alkylguanine residues in DNA in vivo.

Qualification and training of quality assurance personnel

International Nuclear Information System (INIS)

Ribeiro da Costa, J.

1980-01-01

Introduction. Qualification and certification: definitions; approach of the problem. A first attempt for its solutions. The 'sample' course; results and conclusions. Planning a comprehensive program: results. Analysis and preliminary conclusions. Absorption of the know-how and planning further programs for training. Development and updating the general training course with the introduction of German experience - summary of results. General planning of a training course for quality and reliability are as for the next courses. Evaluation, grading and final results awarded to participants, as followed in QA-Training courses - certification. Future trends (tentative) - conclusions. (orig./RW)

External plans for radiological emergency

International Nuclear Information System (INIS)

Suarez, G.; Vizuet G, J.; Benitez S, J.A.

1999-01-01

Since 1989, the National Institute of Nuclear Research in Mexico shares in the task of Food and Water Control corresponding to the FT-86 task force of External Plans for Radiological Emergency (PERE), in charge of the Veracruz Health Services. In the PERE preparation stage previous actions are necessary developed for the preparation and updating of this plan and the task organization with the purpose to maintaining standing and operable in any time and circumstance, the capability to response in the face of an emergency. This stage englobes activities which must be realized before to carry out the Plan as they are the specialized training of personnel which participates and the execution of exercises and simulacrums. Until 1998, training and exercises for this task had been realized under diverse possible sceneries but in conditions that simulated the presence of radioactive material. For this reason, it should be emphasized the training realized during the days 6th, 7th, 8th July, 1999, in the emergency planning zone of the Plan, which to carry out using radioactive material. The National Institute of Nuclear Research had in charge of the training. This work describes all the activities for the realization of this training. (Author)

Egypt boosts family planning.

Science.gov (United States)

1977-10-27

A $4 million Agency for International Development (AID) agreement was signed in Cairo September 30 which will help the Egyptian government increase family planning services. The project is in response to a request for up to $17 million of AID funds for family planning programs during the next 3 years. The funds will pay for: contract advisors to provide short-term in-country training of physicians, architectural and engineering services to renovate a hospital for family planning and obstetrics/gynecology training, and a field training site for family planning service providers. Some Egyptians will receive training in specialized areas in the U.S. and other countries. More than $1.5 million of the $4 million will finance local costs of goods and services required. In addition, it is anticipated that U.S.-owned local currencies will be obligated for direct support of U.S. technical personnel. Over the 3-year life of the project the $17 million from AID plus $664,000 of U.S.-owned local currency will cover 44% of the total costs of selected Egyptian family planning activities. The Egyptian government will contribute at least $18.4 million and the U.N. Fund for Population Activities and the International Bank for Reconstruction and Development will contribute $4.3 million.

Recruiting patients for postgraduate medical training in a community family planning clinic: how do patients want to be asked?

Science.gov (United States)

Heathcote, Jennifer

2008-01-01

To look at patients' views about the way in which they are recruited to assist with postgraduate medical training (i.e. Who is the best person to ask patients to participate? When is the best time for patients to be asked?) and to compare these with clinical practice. Questionnaire surveys of 103 female family planning clinic (FPC) patients and 40 Diploma of the Faculty of Family Planning (DFFP) instructing doctors. Patients were recruited from the waiting room of a community FPC, and DFFP instructing doctors from the North West of England were recruited at an updating meeting. Patients preferred to be recruited by non-medical staff (i.e. receptionist and nurses). Few patients wanted to be asked by the training doctor. Only 9% would find it difficult to refuse a receptionist, 47% would find it difficult to refuse the instructing doctor and 65% would find it difficult to refuse the training doctor. In practice, the commonest person to recruit patients is the instructing doctor. Patients wanted to be given some time to consider the request; this was not always given. Patients may feel coerced into seeing training doctors because they find it difficult to refuse requests, particularly when they are being recruited by doctors. Non-medical staff may be more appropriate for the initial recruitment of patients. Patients need time to consider their involvement. The provision of written information may be useful. Further research is indicated to empower patients' decision-making and reduce the likelihood of coercion.

Web-based training related to NRC staff review of dose modeling aspects of license termination and decommissioning plans

International Nuclear Information System (INIS)

LePoire, D.; Arnish, J.; Cheng, J.J.; Kamboj, S.; Richmond, P.; Chen, S.Y.; Barr, C.; McKenney, C.

2007-01-01

NRC licensees at decommissioning nuclear facilities submit License Termination Plans (LTP) or Decommissioning Plans (DP) to NRC for review and approval. To facilitate a uniform and consistent review of these plans, the NRC developed training for its staff. A live classroom course was first developed in 2005, which targeted specific aspects of the LTP and DP review process related to dose-based compliance demonstrations or modeling. A web-based training (WBT) course is being developed in 2006 to replace the classroom-based course. The advantage of the WBT is that it will allow for staff training or refreshers at any time, while the advantage of a classroom-based course is that it provides a forum for lively discussion and the sharing of experience of classroom participants. The training course consists of the core and advanced modules tailored to specific NRC job functions. Topics for individual modules include identifying the characteristics of simple and complex sites, identifying when outside expertise or consultation is needed, demonstrating how to conduct acceptance and technical reviews of dose modeling, and providing details regarding the level of justification needed for realistic scenarios for both dose modeling and derivation of DCGLs. Various methods of applying probabilistic uncertainty analysis to demonstrate compliance with dose-based requirements are presented. These approaches include: (1) modeling the pathways of radiological exposure and estimating doses to receptors from a combination of contaminated media and radionuclides, and (2) using probabilistic analysis to determine an appropriate set of input parameters to develop derived concentration guideline limits or DCGLs (DCGLs are media- and nuclide-specific concentration limits that will meet dose-based, license termination rule criteria found in 10 CFR Part 20, Subpart E). Calculation of operational (field) DCGL's from media- and nuclide-specific DCGLs and use of operational DCGLs in conducting

Specification of Training Simulator Fidelity: A Research Plan

Science.gov (United States)

1982-02-01

Knowlede --Dunnette (1976) has recently reviewed the literature in the areas of human skills, abilities, and knowledges. The establishment of what types... management 6. Other than rational user responses to R&D studies and to training simulators 7. Deficiencies in training simulator design 23...proficient at managing the introduction of training innovations by applying those factors that can be controlled to influence acceptance. (p. 19) The

Inter-active and dynamic approaches on forest and land-use planning - proceedings from a training workshop

Energy Technology Data Exchange (ETDEWEB)

Sandewall, Mats [ed.

1999-07-01

This document summarises the outcome of a training workshop, 'Inter-active and dynamic approaches on forest and land-use planning', that was organised in Vietnam and Lao PDR during April 1999. The workshop was arranged by researchers from SLU, Umeaa in cooperation with SIDA and it's CCB programme, The National Board of Forestry and concerned government institutions in Lao PDR - The national Programme for Shifting Cultivation Stabilisation, Ministry of Agriculture and Forestry , and in Vietnam - the Forest Inventory and Planning Institute, Ministry of Agriculture and Rural Development. The main purpose of this paper are: (1) to review and conclude the outcome of the workshop to all those who have participated or been concerned with it; (2) to summarise an evaluation of the somewhat unique arrangement, with participants from different sectors, administrative levels, gender and countries; and (3) to present 'the APM approach' on land use planning, which was put forward, tested and discussed during the workshop.

Using 3D Printing to Create Personalized Brain Models for Neurosurgical Training and Preoperative Planning.

Science.gov (United States)

Ploch, Caitlin C; Mansi, Chris S S A; Jayamohan, Jayaratnam; Kuhl, Ellen

2016-06-01

Three-dimensional (3D) printing holds promise for a wide variety of biomedical applications, from surgical planning, practicing, and teaching to creating implantable devices. The growth of this cheap and easy additive manufacturing technology in orthopedic, plastic, and vascular surgery has been explosive; however, its potential in the field of neurosurgery remains underexplored. A major limitation is that current technologies are unable to directly print ultrasoft materials like human brain tissue. In this technical note, the authors present a new technology to create deformable, personalized models of the human brain. The method combines 3D printing, molding, and casting to create a physiologically, anatomically, and tactilely realistic model based on magnetic resonance images. Created from soft gelatin, the model is easy to produce, cost-efficient, durable, and orders of magnitude softer than conventionally printed 3D models. The personalized brain model cost $50, and its fabrication took 24 hours. In mechanical tests, the model stiffness (E = 25.29 ± 2.68 kPa) was 5 orders of magnitude softer than common 3D printed materials, and less than an order of magnitude stiffer than mammalian brain tissue (E = 2.64 ± 0.40 kPa). In a multicenter surgical survey, model size (100.00%), visual appearance (83.33%), and surgical anatomy (81.25%) were perceived as very realistic. The model was perceived as very useful for patient illustration (85.00%), teaching (94.44%), learning (100.00%), surgical training (95.00%), and preoperative planning (95.00%). With minor refinements, personalized, deformable brain models created via 3D printing will improve surgical training and preoperative planning with the ultimate goal to provide accurate, customized, high-precision treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.

Science.gov (United States)

Jansen, M; Bardenheuer, W; Sorg, U R; Seeber, S; Flasshove, M; Moritz, T

2001-07-01

Overexpression of O(6)-methylguanine DNA methyltransferase (MGMT) can protect hematopoietic cells from O(6)-alkylation damage. To identify possible clinical applications of this technology we compared the effect of MGMT gene transfer on the hematotoxicity induced by different O(6)-alkylating agents in clinical use: the chloroethylnitrosoureas ACNU, BCNU, CCNU and the tetrazine derivative temozolomide. In addition, various retroviral vectors expressing the MGMT-cDNA were investigated to identify optimal viral backbones for hematoprotection by MGMT expression. Protection from ACNU, BCNU, CCNU or temozolomide toxicity was evaluated utilizing a Moloney murine leukemia virus-based retroviral vector (N2/Zip-PGK-MGMT) to transduce primary murine bone marrow cells. Increased resistance in murine colony-forming units (CFU) was demonstrated for all four drugs. In comparison to mock-transduced controls, after transduction with N2/Zip-PGK-MGMT the IC50 for CFU increased on average 4.7-fold for ACNU, 2.5-fold for BCNU, 6.3-fold for CCNU and 1.5-fold for temozolomide. To study the effect of the retroviral backbone on hematoprotection various vectors expressing the human MGMT-cDNA from a murine embryonic sarcoma virus LTR (MSCV-MGMT) or a hybrid spleen focus-forming/murine embryonic sarcoma virus LTR (SF1-MGMT) were compared with the N2/Zip-PGK-MGMT vector. While all vectors increased resistance of transduced human CFU to ACNU, the SF1-MGMT construct was most efficient especially at high ACNU concentrations (8-12 microg/ml). Similar results were obtained for protection of murine high-proliferative-potential colony-forming cells. These data may help to optimize treatment design and retroviral constructs in future clinical studies aiming at hematoprotection by MGMT gene transfer.

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

Science.gov (United States)

Esteller, M; Toyota, M; Sanchez-Cespedes, M; Capella, G; Peinado, M A; Watkins, D N; Issa, J P; Sidransky, D; Baylin, S B; Herman, J G

2000-05-01

O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that removes mutagenic and cytotoxic adducts from the O6 position of guanine. O6-methylguanine mispairs with thymine during replication, and if the adduct is not removed, this results in conversion from a guanine-cytosine pair to an adenine-thymine pair. In vitro assays show that MGMT expression avoids G to A mutations and MGMT transgenic mice are protected against G to A transitions at ras genes. We have recently demonstrated that the MGMT gene is silenced by promoter methylation in many human tumors, including colorectal carcinomas. To study the relevance of defective MGMT function by aberrant methylation in relation to the presence of K-ras mutations, we studied 244 colorectal tumor samples for MGMT promoter hypermethylation and K-ras mutational status. Our results show a clear association between the inactivation of MGMT by promoter hypermethylation and the appearance of G to A mutations at K-ras: 71% (36 of 51) of the tumors displaying this particular type of mutation had abnormal MGMT methylation, whereas only 32% (12 of 37) of those with other K-ras mutations not involving G to A transitions and 35% (55 of 156) of the tumors without K-ras mutations demonstrated MGMT methylation (P = 0.002). In addition, MGMT loss associated with hypermethylation was observed in the small adenomas, including those that do not yet contain K-ras mutations. Hypermethylation of other genes such as p16INK4a and p14ARF was not associated with either MGMT hypermethylation or K-ras mutation. Our data suggest that epigenetic silencing of MGMT by promoter hypermethylation may lead to a particular genetic change in human cancer, specifically G to A transitions in the K-ras oncogene.

Strengthening public health nutrition research and training capacities in West Africa: Report of a planning workshop convened in Dakar, Senegal, 26-28 March 2009.

Science.gov (United States)

Brown, Kenneth H; McLachlan, Milla; Cardosa, Placido; Tchibindat, Félicité; Baker, Shawn K

2010-01-01

A three-day workshop was convened in Dakar, Senegal, to provide participants from West African and international academic and research institutions, public health agencies, and donor organisations an opportunity to review current public health nutrition research and training capabilities in West Africa, assess needs for strengthening the regional institutional and workforce capacities, and discuss appropriate steps required to advance this agenda. The workshop included presentations of background papers, experiences of regional and international training programmes and small group discussions. Participants concluded that there is an urgent need to: (1) increase the throughput of public health nutrition training programmes, including undergraduate education, pre-service and in-service professional training, and higher education in public health nutrition and related research skills; and (2) enhance applied research capacity, to provide the evidence base necessary for nutrition program planning and evaluation. A Task Team was appointed to inform the regional Assembly of Health Ministers of the workshop conclusions and to develop political and financial support for a regional nutrition initiative to: (1) conduct advocacy and nutrition stewardship; (2) survey existing training programmes and assist with curriculum development; and (3) develop a plan for a regional applied research institute in Public Health Nutrition.

Contingency planning and emergency response in construction activities: Training the construction worker

International Nuclear Information System (INIS)

Jones, E.

1987-01-01

Construction activities have the potential for environmental and/or health impacts at Oak Ridge National Laboratory (ORNL) particularly as site cleanup and restoration plans are initiated. ORNL has instituted special training for all construction workers and related contractors. Individuals learn how construction activities at ORNL can potentially have adverse effects on the environment and their health, and to learn how to respond to potential chemical and radiation hazards. Workers are given a review of basic information on radiation and chemicals in a framework that emphasizes the situations in which workers or the environment may be exposed to potential risk. Specific instructions are presented on what to do when contamination is suspected, with identification of emergency procedures and response personnel. 5 refs., 1 fig

Slaughterhouse Inspection (Egypt). Training Manual : Guidelines for the Planning and Organisation of Training Activities

NARCIS (Netherlands)

Blomne Sopov, M.; Ghouti, C.A.; Benlafquih, R.; Vugt, van F.; Latief, A.M.A.

2014-01-01

The training manual was prepared for the inspectors of slaughterhouses in Egypt to support the training activities of the General Organization for Veterinary Services (GOVS). The manual has two main parts: 1. Overview on how to design, organize, implement and evaluate training programs in general 2.

Consensus training: an effective tool to minimize variations in periodontal diagnosis and treatment planning among dental faculty and students.

Science.gov (United States)

John, Vanchit; Lee, Seung-Jun; Prakasam, Sivaraman; Eckert, George J; Maupome, Gerardo

2013-08-01

Considerable disagreements and variations exist in diagnosis and treatment planning of periodontal disease. Achieving high interrater periodontal diagnosis can prove challenging. The objectives of this study were to measure variations in periodontal diagnosis and treatment planning among predoctoral periodontics faculty members after consensus training and to compare such variation with those identified in third- and fourth-year dental students. Nine electronically stored case vignettes and survey instruments were made available to eighteen faculty members and twenty dental students under standardized conditions. A chi-square test was used to compare responses between groups, and multirater kappa tests were used to evaluate interrater agreement/reliability. Of the nine cases, only one differed between groups significantly in terms of treatment. Also, third-year students differed from fourth-year students on the diagnosis of aggressive periodontitis versus chronic periodontitis. Most respondents were able to distinguish clearly among diagnoses of chronic periodontitis, aggressive periodontitis, and gingivitis. This study established a baseline assessment of the current status of consensus after training. We will reassess variations after addressing the specific challenges identified. Programs designed and implemented to help decrease the variation in periodontal diagnosis and treatment planning among faculty members may ultimately translate into better agreement and better standardization of dental instruction.

The Effect of Teacher Training on the Knowledge of Positive Behavior Support and the Quality of Behavior Intervention Plans: A Preliminary Study in Taiwan

Science.gov (United States)

Wu, Pei-Fang

2017-01-01

The purpose of this study was to investigate whether through a series of teacher training. The participants could acquire better knowledge on Positive Behavior Support (PBS), and develop high quality behavior intervention plans. Thirty-six teachers from three public schools participated in the study. The competency-based training consisted of 12…

Job training planning and design for process plant operators

International Nuclear Information System (INIS)

Wirstad, J.

1983-01-01

A method is presented by which process plant operators for nuclear power plants are trained in Sweden. It works by a top-down method of systems analysis which can be integrated into the analysis, specification, and design of the process automation system. The training methods can also be adapted to existing automation systems and operating schedules. The author's method is based on the principle that training programs should be based on job requirements, e.g. operator tasks in common, less frequent, and rare operating conditions. Procedures have been tested for the following steps: Job analysis, analysis of knowledge and experience required, analysis of operator training requirements, set-up and organisation of the training programme, achievement control, evaluation of the training programme. (orig./HP) [de

Job training planning and design for process plant operators

Energy Technology Data Exchange (ETDEWEB)

Wirstad, J.

1983-01-01

A method is presented by which process plant operators for nuclear power plants are trained in Sweden. It works by a top-down method of systems analysis which can be integrated into the analysis, specification, and design of the process automation system. The training methods can also be adapted to existing automation systems and operating schedules. The author's method is based on the principle that training programs should be based on job requirements, e.g. operator tasks in common, less frequent, and rare operating conditions. Procedures have been tested for the following steps: Job analysis, analysis of knowledge and experience required, analysis of operator training requirements, set-up and organisation of the training programme, achievement control, evaluation of the training programme.

INDOT Technical Training Plan : [Technical Summary

Science.gov (United States)

2012-01-01

A wide range of job classifications, increasing technical : performance expectations, licensing and certification requirements, : budget restrictions and frequent department : reorganization has made technical training of employees : more difficult, ...

Remedial training for the radiology resident: a template for optimization of the learning plan.

Science.gov (United States)

Mar, Colin; Chang, Silvia; Forster, Bruce

2015-02-01

All radiology residency programs should strive for the early identification of individuals in need of remedial training and have an approach ready to address this situation. This article provides a template for a step-by-step approach which is team based. It includes definition of the learning or performance issues, creation of suitable learning objectives and learning plan, facilitation of feedback and assessment, and definition of outcomes. Using such a template will assist the resident in returning to the path toward a safe and competent radiologist. Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

Family planning providers' perspectives on family planning service delivery in Ibadan and Kaduna, Nigeria: a qualitative study.

Science.gov (United States)

Hebert, Luciana Estelle; Schwandt, Hilary Megan; Boulay, Marc; Skinner, Joanna

2013-01-01

In Nigeria, fertility continues to be high and contraceptive prevalence remains low. This study was conducted in order to understand the perceptions of, experiences with and challenges of delivering family planning services in two urban areas of Nigeria from the perspectives of family planning service providers. A qualitative study using 59 in-depth interviews was conducted among family planning providers working in hospitals, primary health centres, clinics, pharmacies and patent medicine vendors in Ibadan and Kaduna, Nigeria. Providers support a mix of individuals and organisations involved in family planning provision, including the government of Nigeria. The Nigerian government's role can take a variety of forms, including providing promotional materials for family planning facilities as well as facilitating training and educational opportunities for providers, since many providers lack basic training in family planning provision. Providers often describe their motivation to provide in terms of the health benefits offered by family planning methods. Few providers engage in any marketing of their services and many providers exclude youth and unmarried individuals from their services. The family planning provider community supports a diverse network of providers, but needs further training and support in order to improve the quality of care and market their services. Adolescents, unmarried individuals and women seeking post-abortion care are vulnerable populations that providers need to be better educated about and trained in how to serve. The perspectives of providers should be considered when designing family planning interventions in urban areas of Nigeria.

Astronaut training plans and training facilities in Japan; Uchu hikoshi tanjo eno michi (kunren to kunren setsubi)

Energy Technology Data Exchange (ETDEWEB)

Harada, C. [National Space Development Agency of Japan, Tokyo (Japan)

1999-10-05

Introduced are the training of astronauts for duties aboard a space shuttle, training provided by NASDA (National Space Development Agency of Japan), and training facilities. The astronaut candidate training course involves space science, space medicine, ocean science, and others, in addition to flight training aboard the T-38 jet trainer, emergency procedure training, shuttle system training, weightlessness training aboard the KC-135 jet plane on a ballistic flight, and SCUBA training. After candidates are named to serve aboard the space shuttle, they are to undergo training related to the shuttle system, emergency exit, adaptation to the surroundings, and the space laboratory system. As for ISS (international space station), astronauts will have to construct the station, and to stay there for a long time operating and maintaining the station and manipulating various experimental apparatuses. The astronaut training process in Japan covers approximately four years, including candidate training, advanced training, and mission dependent training. The training facilities include a weightless environment test system, low-pressure environment adaptation training system, etc., available at NASDA's Tsukuba Space Center. (NEDO)

Differential approach to planning of training loads in person with connective tissue dysplasia symptoms

Directory of Open Access Journals (Sweden)

Олег Борисович Неханевич

2015-05-01

Full Text Available Introduction. When dealing with issues of access and planning of training and competitive pressures special interest cause the person with signs of connective tissue dysplasia.Aim. Improvement of medical support of training process of athletes with signs of connective tissue dysplasia.Materials and methods. 188 athletes are examined, including 59 with signs of connective tissue dysplasia. There are made the basic group. Signs of systemic involvement of connective tissue are determined using anthropometry and somatoscopy. An echocardiographic examination is conducted for all athletes at rest and during bicycle ergometry in regenerative period conducted.Results. Underweight body, acromacria, hypermobility of joints and flat feet are often observed with signs of systemic involvement of connective tissue.During veloergometry it was established deterioration of myocardial relaxation during diastole core group of athletes while performing load average power, which led to a drop in ejection fraction at submaximal levels of exertion.Conclusions. Existence of connective tissue dysplasia in athletes with different prognosis states requires sports physicians an in-depth analysis and differential diagnosis of clinical forms in order to prevent complications during training and competitive pressures. Early signs of cardiac strain while performing physical activity in athletes with signs of connective tissue dysplasia were symptoms of myocardial relaxation on indicators of diastolic heart function. Ejection fraction at rest remained at normal levels

Advance care planning in a community setting.

Science.gov (United States)

Connolly, Josaleen; Milligan, Stuart; Stevens, Elaine; Jackson, Susan; Rooney, Kevin

2015-02-10

To evaluate the effects of implementing an advance care planning process within pilot sites in North Ayrshire in 2010, focusing on people with palliative care needs. Data were collected from participants in advance care planning training using a questionnaire. Semi-structured interviews were conducted and an audit of documentation was undertaken. Thirty nine questionnaires were returned, a response rate of 16%. Twenty four out of 25 (96%) participants rated the training as having improved their understanding of the advance care planning process. The general consensus in interviews was that advance care planning is a worthwhile process. Participants reported patients achieving their preferred place of end of life care and greater consultation regarding hospitalisation. Within the pilot sites, advance care planning training enhanced the ability of professionals to implement the advance care planning process and record the wishes of patients and residents.

Nuclear safety education and training network

International Nuclear Information System (INIS)

Bastos, J.; Ulfkjaer, L.

2004-01-01

In March 2001, the Secretariat convened an Advisory Group on Education and Training in nuclear safety. The Advisory Group considered structure, scope and means related to the implementation of an IAEA Programme on Education and Training . A strategic plan was agreed and the following outputs were envisaged: 1. A Training Support Programme in nuclear safety, including a standardized and harmonized approach for training developed by the IAEA and in use by Member States. 2. National and regional training centres, established to support sustainable national nuclear safety infrastructures. 3. Training material for use by lecturers and students developed by the IAEA in English and translated to other languages. The implementation of the plan was initiated in 2002 emphasizing the preparation of training materials. In 2003 a pilot project for a network on Education and Training in Asia was initiated

Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis.

Science.gov (United States)

Watanabe, Takao; Katayama, Yoichi; Ogino, Akiyoshi; Ohta, Takashi; Yoshino, Atsuo; Fukushima, Takao

2006-08-01

O(6)-methylguanine-deoxyribonucleic acid methyltransferase gene (MGMT) methylation is apparently correlated with responsiveness to nitrosourea chemotherapy, suggesting this alkylating agent should be effective against MGMT-methylated tumors. MGMT appears not to be linked to platinum resistance, so platinum chemotherapy should be used for MGMT-unmethylated tumors. This study was a preliminary trial of individualized chemotherapy based on MGMT methylation status in a total of 20 patients with newly diagnosed malignant astrocytomas (9 anaplastic astrocytomas and 11 glioblastomas multiforme). The procarbazine, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, and vincristine (PAV) regimen was administered to seven patients with MGMT-methylated tumors, and the carboplatin and etoposide (CE) regimen was administered to 13 patients with MGMT-unmethylated tumors. Objective response to the PAV therapy was noted in all three patients with measurable residual tumor (2 complete responses and 1 partial response). Five of the seven patients continued to be disease-free after initiation of the PAV therapy. Objective response to the CE therapy was seen in only one of seven patients with measurable residual tumor (1 partial response). Three of the 13 patients were free from progression, whereas the remaining 10 patients showed early progression. The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors.

Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.

Science.gov (United States)

Shiraishi, A; Sakumi, K; Sekiguchi, M

2000-10-01

O(6)-methylguanine-DNA methyltransferase plays vital roles in preventing induction of mutations and cancer as well as cell death related to alkylating agents. Mice defective in the MGMT: gene, encoding the methyltransferase, were used to evaluate cell death-inducing and tumorigenic activities of therapeutic agents which have alkylation potential. MGMT(-/-) mice were considerably more sensitive to dacarbazine, a monofunctional triazene, than were wild-type mice, in terms of survival. When dacarbazine was administered i.p. to 6-week-old mice and survival at 30 days was enumerated, LD(50) values of MGMT(-/-) and MGMT(+/+) mice were 20 and 450 mg/kg body wt, respectively. Increased sensitivity of MGMT(-/-) mice to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosou rea (ACNU), a bifunctional nitrosourea, was also noted. On the other hand, there was no difference in survival of MGMT(+/+) and MGMT(-/-) mice exposed to cyclophosphamide, a bifunctional nitrogen mustard. It appears that dacarbazine and ACNU produce O(6)-alkylguanine as a major toxic lesion, while cyclophosphamide yields other types of modifications in DNA which are not subjected to the action of the methyltransferase. MGMT(-/-) mice seem to be less refractory to the tumor-inducing effect of dacarbazine than are MGMT(+/+) mice. Thus, the level of O(6)-methylguanine-DNA methyltransferase activity is an important factor when determining susceptibility to drugs with the potential for alkylation.

Evaluation of training in the health sector. Results of training on the use of medicines

Directory of Open Access Journals (Sweden)

Pilar Pineda-Herrero

2012-11-01

Full Text Available The evaluation of training efficacy is one of the challenges of today’s organizations. In this article we present the results of an evaluation carried out in order to measure transfer of a training plan about the rational use of medicines addressed to 1550 health professionals. Data is collected by means of a survey to the trainee, two months after the training program. Results show that most of the trainees have improved their professional performance, in special the duties related to the selection and use of medicines. Key factors for transfer are also detected, such as motivation and support from the organization. In the paper, we reflect on the strengths and weaknesses of the training plan so as to help other researchers and practitioners to advance towards improving transfer of training and the efficacy of training.  

ACADEMIC TRAINING LECTURES-QUESTIONNAIRE

CERN Multimedia

Françoise Benz

2004-01-01

ACADEMIC TRAINING Françoise Benz tel. 73127 academic.training@cern.ch SUGGEST AND WIN! Its time to plan the 2004-2005 lecture series. From today until March 19 you have the chance to give your contribution to planning for next year's Academic Training Lecture Series. At the web site: http://cern.ch/Academic.Training/questionnaire you will find questionnaires proposing topics in high energy physics, applied physics and science and society. Answering the questionnaire will help ensure that the selected topics are as close as possible to your interests. In particular requests and comments from students will be much appreciated. To encourage your contribution, the AT Committee will reward one lucky winner with a small prize, a 50 CHF coupon for a book purchase at the CERN bookshop.

Staff training program of CANDU projects in Saskatoon

International Nuclear Information System (INIS)

Huterer, J.

1996-01-01

This paper describes the training process for a nuclear project on a new site. When AECL opened a project office Saskatoon, senior management recognized the need for large scale staff training and made the necessary commitments. Two types of training programs were initiated, general and technical. The general training plan included topics related to nuclear project life cycle. Technical training was discipline and task specific. Based on the job descriptions and staff qualifications, technical training requirements were documented for the entire staff. The training strategy was developed and implemented. Detailed records were maintained to monitor the progress, draw conclusions, and plan training for future nuclear facilities. (author)

IPPO training: socio-psychological training with horses

Directory of Open Access Journals (Sweden)

Doronina T. V.

2016-09-01

Full Text Available This article describes the socio-psychological training with horses "Ippo-training", aimed at the development of social competence of the participants, including interper- sonal perception, nonverbal means of communication, self-confidence, responsibility and commitment. The theoretical foundations of ippo-training from the points of social and animal psychology are examined. In particular, the author reveals the behavioral features of horses as social animals, the hierarchical structure of the herd, in which a person may be involved as the leader, which enables to find theoretical and behavioral similarities with the life of people in the society. The author indicates the main purpose of this type of work, results of ippo-training and variants of training for different types of participants — family, corporate or public ippo training. The article also provides guide- lines for conducting the training, technical requirements, qualifications which leaders need (psychologists and horsemen, safety techniques and an exemplary work plan.

LA PLANIFICACIÓN DE LOS CONTENIDOS DE ENTRENAMIENTO DE BALONCESTO EN EQUIPOS DE INICIACIÓN [Planning the contents of training in early age basketball teams

Directory of Open Access Journals (Sweden)

María Cañadas Alonso

2010-04-01

basketball process training was in initation stage. Specifically how to plan the contents of this sport over a season. For that, training activities planned by a coach who performed their work in a initation team were analyzed. 846 training activities for two seasons were studied. All training sessions were introduced in the PYC-Basket program to quantify the training. The study variables were the contents of training and media training. An initial descriptive analysis of the data to understand how the planning process was carried out. Subsequently, an inferential analysis was performed to study the relationship between two variables and examine the way it presents the development of each content. The planning and recording of the elements that define the coaching situation allowed the control of the programming content of training. The results show a predominance of technical contents, particularly of the individual gestures of attack. Contents also evolve in their treatment during the analyzed seasons. The individual technical and tactical gestures increase over the season. The individual technical and tactical behaviors were reduced with increasing tactical behaviors and collective group techniques. In the planned tasks, the use of means such as exercises and training games for each type of content were combined. Exercises were used to develop the technique and tactics games. Keywords: pedagogical variables, coaching, sport initiation, planning, contents, basketball.

LA PLANIFICACIÓN DE LOS CONTENIDOS DE ENTRENAMIENTO DE BALONCESTO EN EQUIPOS DE INICIACIÓN [Planning the contents of training in early age basketball teams

Directory of Open Access Journals (Sweden)

María Cañadas Alonso

2010-04-01

how basketball process training was in initation stage. Specifically how to plan the contents of this sport over a season. For that, training activities planned by a coach who performed their work in a initation team were analyzed. 846 training activities for two seasons were studied. All training sessions were introduced in the PYC-Basket program to quantify the training. The study variables were the contents of training and media training. An initial descriptive analysis of the data to understand how the planning process was carried out. Subsequently, an inferential analysis was performed to study the relationship between two variables and examine the way it presents the development of each content. The planning and recording of the elements that define the coaching situation allowed the control of the programming content of training. The results show a predominance of technical contents, particularly of the individual gestures of attack. Contents also evolve in their treatment during the analyzed seasons. The individual technical and tactical gestures increase over the season. The individual technical and tactical behaviors were reduced with increasing tactical behaviors and collective group techniques. In the planned tasks, the use of means such as exercises and training games for each type of content were combined. Exercises were used to develop the technique and tactics games. Keywords: pedagogical variables, coaching, sport initiation, planning, contents, basketball.

How to measure training effectiveness

CERN Document Server

Rae, Leslie

1986-01-01

Assessing training for effectiveness and value, this book covers the entire process from selecting and planning a training event, to validating and testing its outcome. This new, up-to-date edition includes details of the competence standards from the Training and Development

Self-Perceived Benefits of Cognitive Training in Healthy Older Adults

Directory of Open Access Journals (Sweden)

Vina M. Goghari

2018-04-01

Full Text Available The idea that individualized, computer-based cognitive training improves cognitive functioning in non-trained domains is highly contested. An understudied area is whether cognitive training improves one’s own perception of cognitive and day-to-day functioning. Furthermore, no studies have compared working memory training to programs that train higher-level processes themselves, namely logic and planning, in improving perception of cognitive abilities. We investigated self-reported changes in: (a cognitive errors relevant to daily life; (b expectations regarding training; and (c impact of training on daily life, in healthy older adults who completed working memory training or logic and planning training. Ninety-seven healthy older adults completed 8-weeks of computerized cognitive training that targeted either working memory or logic and planning. Findings were compared to a no-training control group. Participants reported fewer cognitive failures relevant to daily life after training compared to the no-training control group, with a greater reduction in errors reported by the logic and planning training group compared to the working memory training group. Trainees’ perception of training efficacy decreased over time. Nonetheless, approximately half of the participants in both training groups endorsed “some improvement” or more in self-perceived day-to-day functioning at post-testing. These results support the conclusion that individualized computerized cognitive training may enhance subjective perceptions of change and that higher level cognitive training may confer additional benefits. Findings suggest that cognitive training can enhance cognitive self-efficacy in healthy seniors.

Case Study: Does training of private networks of Family Planning clinicians in urban Pakistan affect service utilization?

OpenAIRE

Qureshi, Asma M

2010-01-01

Abstract Background To determine whether training of providers participating in franchise clinic networks is associated with increased Family Planning service use among low-income urban families in Pakistan. Methods The study uses 2001 survey data consisting of interviews with 1113 clinical and non-clinical providers working in public and private hospitals/clinics. Data analysis excludes non-clinical providers reducing sample size to 822. Variables for the analysis are divided into client vol...

Planning and Programming of Education and Training Courses on the Radiation Fusion Technologies for Next Generations

International Nuclear Information System (INIS)

Kim, Jin Kyu; Nam, Y. M.; Choi, P. H.

2009-06-01

In order to program education and training courses on the radiation technologies and to have the WNU RT School to be held in Korea, this project was carried out. It was also done to make a strategy for running the programmed courses, and to build and knit a global network among radiation specialists such as international advisory board, domestic advisory board and steering committee. A plan for the WNU RT School in Korea was made under this project. Curricula in all subjects related to radiation technology and the lecture materials were prepared, which are essential for education and training courses on radiation technologies for next generations. Lecturers were selected among global CEOs and professionals in radiation industries and university professors and radiation specialists. In addition, a global network among radiation specialists such as international advisory board, domestic advisory board and steering committee was built and organized. As a model for the international education and training courses in RT field as well as the other fields, it can be used for making fundamentals of technology exports and promoting Korea's national image in science and technology

Quality Assurance Plan for Transportation Management Division Transportation Training Programs

International Nuclear Information System (INIS)

1994-10-01

The U.S. Department of Transportation (DOT) implemented new rules requiring minimum levels of training for certain key individuals who handle, package, transport, or otherwise prepare hazardous materials for transportation. In response to these rules, the U.S. Department of Energy (DOE), Transportation Management Division (TMD), has developed a transportation safety training program. This program supplies designed instructional methodology and course materials to provide basic levels of DOT training to personnel for whom training has become mandatory. In addition, this program provides advanced hazardous waste and radioactive material packaging and transportation training to help personnel achieve proficiency and/or certification as hazardous waste and radioactive material shippers. This training program does not include site-specific or task-specific training beyond DOT requirements

Training of engineering personnel - Ad-hoc or science

International Nuclear Information System (INIS)

Popovic, J.; MacIsaac, M.

2005-01-01

The training programs at AECL, with emphasis on training of technical employees is described and discussed. Implementation of Systematic Approach to Training (SAT) principles, establishments of individual and organizational unit career development and training plans, commitment for training budget, and assessment on training effectiveness are presented. There is also recognition of the importance of informal training for on-going continued development of staff, around key specialists/subject-matter experts, through mentoring and establishment of small centers of excellence, as part of the technical succession planning program. There is a discussion on what works well and what needs improvements. These approaches to training promise improvements in training and career development of individual employees and implementation of the Corporate training objectives. (author)

Nuclear power training courses

International Nuclear Information System (INIS)

1977-01-01

The training of technical manpower for nuclear power projects in developing countries is now a significant part of the IAEA Technical Assistance Programme. Two basic courses are the cornerstones of the Agency's training programme for nuclear power: a course in planning and implementation, and a course in construction and operation management. These two courses are independent of each other. They are designed to train personnel for two distinct phases of project implementation. The nuclear power project training programme has proven to be successful. A considerable number of highly qualified professionals from developing countries have been given the opportunity to learn through direct contact with experts who have had first-hand experience. It is recognized that the courses are not a substitute for on-the-job training, but their purpose is achieved if they have resulted in the transfer of practical, reliable information and have helped developing countries to prepare themselves for the planning, construction and operation management of nuclear power stations

Momentum: "Developing Masterful Marketing Plans."

Science.gov (United States)

Meservey, Lynne D.

1988-01-01

Describes how directors can plan and develop a written marketing plan which can increase enrollment at child care centers. Components of successful marketing plans include parent retention; program merchandising; staff and director training; sales promotions; networking; and enrichment programs/fundraising. (NH)

Study of a proposal for the insertion of operational experience as a tool for support the training plan for nuclear power plants

International Nuclear Information System (INIS)

Fonseca, Renato Alves da

2009-05-01

The main objectives of this work are: to determine, through the operational experience analysis of Angra 1 nuclear power plant, the plant operational vulnerabilities that affect its staff training and to propose a modeling to plan a training program to address these vulnerabilities. This analysis utilizes the Angra 1 document entitled 'Ocorrencia de Relato Obrigatorio', which reports the plant event occurrences. Through this document, as well as the opinion of specialists on the most probably root causes of the reported events, the backdrop of the operational experience analysis of internal events was built. The modeling using the SAT method and has as a guideline the internal operational experience analysis. Moreover, this modeling encompasses techniques of event and second generation human reliability analysis, both specific of the nuclear area. The development of this work shows that: the internal operational experience analysis provides a realistic view of the vulnerabilities present in the plant in all areas (technical and organizational), which must be addressed to the plan of the training program and the modeling, based on realistic view of the plant, is dynamic, not linear, and is always up to date on events in the plant, its causes and consequences. (author)

Chemical Hygiene and Safety Plan

Energy Technology Data Exchange (ETDEWEB)

Berkner, K.

1992-08-01

The objective of this Chemical Hygiene and Safety Plan (CHSP) is to provide specific guidance to all LBL employees and contractors who use hazardous chemicals. This Plan, when implemented, fulfills the requirements of both the Federal OSHA Laboratory Standard (29 CFR 1910.1450) for laboratory workers, and the Federal OSHA Hazard Communication Standard (29 CFR 1910.1200) for non-laboratory operations (e.g., shops). It sets forth safety procedures and describes how LBL employees are informed about the potential chemical hazards in their work areas so they can avoid harmful exposures and safeguard their health. Generally, communication of this Plan will occur through training and the Plan will serve as a the framework and reference guide for that training.

49 CFR 193.2715 - Training: security.

Science.gov (United States)

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Training: security. 193.2715 Section 193.2715...: FEDERAL SAFETY STANDARDS Personnel Qualifications and Training § 193.2715 Training: security. (a) Personnel responsible for security at an LNG plant must be trained in accordance with a written plan of...

Testing the feasibility of training peers with a spinal cord injury to learn and implement brief action planning to promote physical activity to people with spinal cord injury

Science.gov (United States)

Gainforth, Heather L.; Latimer-Cheung, Amy E.; Davis, Connie; Casemore, Sheila; Martin Ginis, Kathleen A.

2015-01-01

Objective The present study tested the feasibility of training peers with spinal cord injury (SCI) to learn brief action planning (BAP), an application of motivational interviewing principles, to promote physical activity to mentees with SCI. Method Thirteen peers with SCI attended a half-day BAP workshop. Using a one-arm, pre-, post-test design, feasibility to learn BAP was assessed in terms of peers' (1) BAP and motivational interviewing spirit competence; (2) training satisfaction; and (3) motivations to use BAP as assessed by measures of the theory of planned behavior constructs. Measures were taken at baseline, immediately post-training, and 1 month follow up. Results Following the training, participants' BAP and motivational interviewing competence significantly increased (P's  2.27). Training satisfaction was very positive with all means falling above the scale midpoint. Participants' perceived behavioral control to use BAP increased from baseline to post (P  0.05). Conclusion Training peers with a SCI to learn to use BAP is feasible. Practical implications BAP is a tool that can be feasibly learned by peers to promote physical activity to their mentees. PMID:25429692

30 CFR 250.1503 - What are my general responsibilities for training?

Science.gov (United States)

2010-07-01

... plan that specifies the type, method(s), length, frequency, and content of the training for your employees. Your training plan must specify the method(s) of verifying employee understanding and performance... establish and implement a training program so that all of your employees are trained to competently perform...

Statistical Analysis Plan

DEFF Research Database (Denmark)

Ris Hansen, Inge; Søgaard, Karen; Gram, Bibi

2015-01-01

This is the analysis plan for the multicentre randomised control study looking at the effect of training and exercises in chronic neck pain patients that is being conducted in Jutland and Funen, Denmark. This plan will be used as a work description for the analyses of the data collected....

O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro.

Science.gov (United States)

Liu, Y; Egyhazi, S; Hansson, J; Bhide, S V; Kulkarni, P S; Grafström, R C

1997-10-01

Extracts prepared from tissue specimens of normal, non-tumourous human buccal mucosa, and cultured buccal epithelial cells and fibroblasts, exhibited O6-methylguanine-DNA methyltransferase (MGMT) activity by catalysing the repair of the premutagenic O6-methylguanine lesion in isolated DNA with rates of 0.2 to 0.3 pmol/mg protein. An SV40 T antigen-immortalized buccal epithelial cell line termed SVpgC2a and a buccal squamous carcinoma line termed SqCC/Y1, both of which lack normal tumour suppressor gene p53 function, exhibited about 50 and 10% of the MGMT activity of normal cells, respectively. The normal, experimentally transformed and tumourous buccal cell types showed MGMT mRNA levels which correlated with their respective levels of MGMT activity. Exposure of buccal cell cultures to various organic or water-based extracts of products related to the use of tobacco and betel quid, decreased both cell survival (measured by reduction of tetrazolium dye) and MGMT activity (measured subsequently to the exposures in cellular extracts). Organic extracts of bidi smoke condensate and betel leaf showed higher potency than those of tobacco and snuff. An aqueous snuff extract also decreased both parameters, whereas an aqueous areca nut extract was without effect. The well-established sulph-hydryl-reactive agent Hg2+, a corrosion product of dental amalgam, served as a positive control and decreased MGMT activity following treatment of cells within a range of 1-10 microM. Taken together, significant MGMT activities were demonstrated in buccal tissue specimens and in the major buccal mucosal cell types in vitro. Lower than normal MGMT activity in two transformed buccal epithelial cell lines correlated with decreased MGMT mRNA and lack of functional p53. Finally, in vitro experiments suggested the potential inhibition of buccal mucosal MGMT activity by complex mixtures present in the saliva of tobacco and betel nut chewers.

[Continuing training plan in a clinical management unit].

Science.gov (United States)

Gamboa Antiñolo, Fernando Miguel; Bayol Serradilla, Elia; Gómez Camacho, Eduardo

2011-01-01

Continuing Care Unit (UCA) focused the attention of frail patients, polypathological patients and palliative care. UCA attend patients at home, consulting, day unit, telephone consulting and in two hospitals of the health area. From 2002 UCA began as a management unit, training has been a priority for development. Key elements include: providing education to the workplace, including key aspects of the most prevalent health care problems in daily work, directing training to all staff including organizational aspects of patient safety and the environment, improved working environment, development of new skills and knowledge supported by the evidence-based care for the development of different skills. The unit can be the ideal setting to undertake the reforms necessary conceptual training of professionals to improve the quality of care. 2010 SESPAS. Published by Elsevier Espana. All rights reserved.

Training in AB Department 2004/2005

CERN Document Server

Schinzel, Josi; CERN. Geneva. AB Department

2006-01-01

This note provides an overview of the training attended by members of the AB Department during the years 2004 and 2005, giving a break-down of the different courses and costs as well as training directions. It describes the organisation of training in the department, and evolution in training directions and planning.

Training for hazardous waste workers

Energy Technology Data Exchange (ETDEWEB)

Favel, K.

1990-10-26

This implementation plan describes the system and provides the information and schedules that are necessary to comply with the Department of Energy (DOE) Albuquerque Operations Office (AL) Memorandum, Reference EPD dated September 11, 1990, Training for Hazardous Waste Workers. The memo establishes the need for identifying employees requiring environmental training, ensuring that the training is received, and meeting documentation and recordkeeping requirements for the training.

Operations Research for Freight Train Routing and Scheduling

DEFF Research Database (Denmark)

Harrod, Steven; Gorman, Michael F.

2011-01-01

This article describes the service design activities that plan and implement the rail freight operating plan. Elements of strategic service design include the setting of train frequency, the routing of cars among trains, and the consolidation of cars, called blocking. At the operational level......, trains are dispatched either according to train paths configured in advance, called timetables, or according to priority rules. We describe the North American and European practice along with selected modeling and problem solving methodologies appropriate for each of the operating conditions described...

The nuclear emergency plans

International Nuclear Information System (INIS)

Fuertes Menendez, M. J.; Gasco Leonarte, L.; Granada Ferrero, M. J.

2007-01-01

Planning of the response to emergencies in nuclear plants is regulated by the Basic Nuclear Emergency Plan (PLABEN). This basic Plan is the guidelines for drawing up, implementing and maintaining the effectiveness of the nuclear power plant exterior nuclear emergency plans. The five exterior emergency plans approved as per PLABEN (PENGUA, PENCA, PENBU, PENTA and PENVA) place special emphasis on the preventive issues of emergency planning, such as implementation of advance information programs to the population, as well as on training exercises and drills. (Author)

A new tool to measure training load in soccer training and match play

DEFF Research Database (Denmark)

Rebelo, A; Brito, J; Seabra, A

2012-01-01

-based methods (TRIMP and Edwards' method). 51 soccer players (age 15.6±0.3 years) answered 2 questions to assess perceived exertion and fatigue (VAS1-TL, and VAS2-TL) after training sessions and official matches. Performance in the Yo-Yo tests, VAS scores and heart rate of training sessions and matches......An accurate evaluation of training load is paramount for the planning and periodization of training. The aim of the present study was to evaluate the relationship between a new method to monitor training load in soccer (Visual Analogic Scale training load; VAS-TL), and two established heart rate...

Training at Aerospatiale

Science.gov (United States)

Chabod, Rene

A training plan for Aerospatiale is outlined which incorporates goals for both the organization and the individual. Emphasis is placed on the training of staff in multiple skills such as mechanics/electronics. Other areas considered include the development of information tools, the development of commercial approaches, and the learning of new industrial techniques and foreign languages.

CFD simulation of train aerodynamics : train-induced wind conditions at an underground railroad passenger platform

NARCIS (Netherlands)

Khayrullina, A.; Blocken, B.J.E.; Janssen, W.D.; Straathof, J.

2015-01-01

The Dutch railways plan to increase the amount of trains and their running velocities to avoid overcrowded trains during rush hours. This can cause pedestrian wind discomfort or danger at the platforms as trains will be allowed to pass small railway stations at high speeds up to 140 km/h. A number

Human Factors Review Plan

International Nuclear Information System (INIS)

Paramore, B.; Peterson, L.R.

1985-12-01

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management

Human Factors Review Plan

Energy Technology Data Exchange (ETDEWEB)

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

42 CFR 432.31 - Training and use of subprofessional staff.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Training and use of subprofessional staff. 432.31...; Subprofessional and Volunteer Programs § 432.31 Training and use of subprofessional staff. (a) State plan requirement. A State plan must provide for the training and effective use of subprofessional staff as...

The Effect of Training on Adopting Behaviors Preventing from Knee Osteoarthritis Based on Planned Behavior Theory

Directory of Open Access Journals (Sweden)

S

2015-05-01

Full Text Available Introduction: the arthritis is believed to be among common diseases which prevail in the developed and developing countries, including Iran. In demographic studies, the prevalence of knee arthritis which stands at %15/3 in the population above 15-years old was shown. Owing to the fact that societies are about to be aged than before, the issue has become a growing significance in the subject matter of public health. The present study is conducted with an aim to investigate into the effect of training based on the planned behavior model on preventing the teachers of preliminary schools from getting knee arthritis. Methods: the study as an intervention research is of quasi-experimental kind. The population in question included 114 individuals among female teachers of preliminary schools who were brought to the study randomly and divided into two groups intervention and non-intervention. Based on the primary results, the educational contents were designed and submitted in the intervention group. After two months of executing the training program, the post test was carried out. The data was analyzed by SPSS version 18. Due to the loss of normality in data distribution, non- parametric tests were used. Results: the study demonstrated that the components of the planned behavior theory (i.e. the attitudes, subjective norms and the control of perceived behavior could altogether estimate %37 of intention and %43 of behavior. Meanwhile, the role of subjective norms (β =56/0 in predicting intention was overriding, In this study,after the educational program, control of perceived behavior scores increased of 32/50 ± 4/05 to 34/82 ± 5/66. indicating that the major obstacles in adopting behaviors preventing from knee arthritis are the lack of regular physical activity (%72/4 and failure to use western-style toilet (%57. Conclusion: In this Study the effect theory of planned behavior support in predicting exercise intentions and behavior in the prevention of

The Impact of Appearance Management Training, Work Status, and Plans after High School on Opinions Regarding Appearance at Work and School

Science.gov (United States)

Freeburg, Beth Winfrey; Arnett, Sally E.

2010-01-01

The purpose of this study was to measure the effect of appearance management training, work status, and plans after high school on students' opinions about appearance at school and at work. A nonprobability sample of 132 high school juniors and seniors in a consumer education class were administered the Appearance Management Survey before and…

Project management plan, Hazardous Materials Management and Emergency Response Training Center

International Nuclear Information System (INIS)

Borgeson, M.E.

1994-01-01

For the next 30 years, the main activities at the Hanford Site will involve the handling and cleanup of toxic substances. Thousands of workers involved in these new activities will need systematic training appropriate to their tasks and associated risks. This project is an important part of the Hanford Site mission and will enable the US Department of Energy (DOE) to meet high standards for safety. The Hazardous Materials Management and Emergency Response Training Center (HAMMER) project will construct a centralized regional training center dedicated to training hazardous materials workers and emergency responders in classrooms and with hands-on, realistic training aids representing actual field conditions. The HAMMER Training Center will provide a cost-effective, high-quality way to meet the Hanford Site training needs. The training center creates a partnership among DOE; government contractors; labor; local, state, and tribal governments; and selected institutions of higher education

Effectiveness of training on preventative nutritional behaviors for type-2 diabetes among the female adolescents: Examination of theory of planned behavior.

Science.gov (United States)

Maleki, Farzaneh; Hosseini Nodeh, Zahra; Rahnavard, Zahra; Arab, Masoume

2016-01-01

Since type-2 diabetes is the most common chronic disease among Iranian female adolescents, we applied theory of planned behavior to examine the effect of training to intention to preventative nutritional behaviors for type-2 diabetes among female adolescents. In this experimental study 200 (11-14 year old) girls from 8 schools of Tehran city (100 in each intervention and control group) were recruited based on cluster sampling method during two stages. For intervention group, an educational program was designed based on the theory of planned behavior and presented in 6 workshop sessions to prevent type-2 diabetes. The data were collected before and two months after the workshops using a valid and reliable (α=0.72 and r=0.80) authormade questionnaire based on Ajzens TPB questionnaire manual. The data were analyzed using t-test, chi-square test and analysis of covariance. Findings indicate that the two groups were homogeneous regarding the demographic characteristics before education, but the mean score of the theory components (attitudes, subjective norms, perceived behavioral control, and intention) was higher in the control group. Also, results showed all of the theory components significantly increased after the education in the intervention group (p=0.000). Training based on the theory of planned behavior enhances the intention to adherence preventative nutritional behaviors for type-2 diabetes among the studied female adolescents.

OPTIMAL TRAINING POLICY FOR PROMOTION - STOCHASTIC MODELS OF MANPOWER SYSTEMS

Directory of Open Access Journals (Sweden)

V.S.S. Yadavalli

2012-01-01

Full Text Available In this paper, the optimal planning of manpower training programmes in a manpower system with two grades is discussed. The planning of manpower training within a given organization involves a trade-off between training costs and expected return. These planning problems are examined through models that reflect the random nature of manpower movement in two grades. To be specific, the system consists of two grades, grade 1 and grade 2. Any number of persons in grade 2 can be sent for training and after the completion of training, they will stay in grade 2 and will be given promotion as and when vacancies arise in grade 1. Vacancies arise in grade 1 only by wastage. A person in grade 1 can leave the system with probability p. Vacancies are filled with persons in grade 2 who have completed the training. It is assumed that there is a perfect passing rate and that the sizes of both grades are fixed. Assuming that the planning horizon is finite and is T, the underlying stochastic process is identified as a finite state Markov chain and using dynamic programming, a policy is evolved to determine how many persons should be sent for training at any time k so as to minimize the total expected cost for the entire planning period T.

Systematic development of training plan for maintenance people

International Nuclear Information System (INIS)

Mendizabal, J.L.; Moron, P.

1995-01-01

After TMI's accident, the american industry began a process to solve the problems detected, in order to ensure a trust able, secure and efficient production of the nuclear installations. With this objective was created INPO. This organization and NCR later has recommended that the training programmes of the personnel performing their activity in nuclear installations should be supported by a systematic analysis based in the job position's profit. The european industry has taken the risk in the same aspect, recommending through the IAEA the application of a similar process in its activity's field, as shown is the IAEA-TECDOC-525 document. Moreover, this methodological development endeavour to be the way of performing the demand of electric energy plants training departments, which keep demanding, day by day, training methodologies related to the principle that this should start, in its design, from the labour reality of its plant's personnel, and approach to the same labour reality in its application. (Author)

STS payloads mission control study. Volume 2-A, Task 1: Joint products and functions for preflight planning of flight operations, training and simulations

Science.gov (United States)

1976-01-01

Specific products and functions, and associated facility availability, applicable to preflight planning of flight operations were studied. Training and simulation activities involving joint participation of STS and payload operations organizations, are defined. The prelaunch activities required to prepare for the payload flight operations are emphasized.

SAT in operations training

International Nuclear Information System (INIS)

Gonzalez, M.

1995-01-01

The selection of tasks for analysis is made based on the decision tree that incorporates management's expectations of task difficulty and importance. The training setting (e.g., OJT, classroom, simulator, or laboratory) and the steps necessary to prepare the final training plan (along with example training plans for RO/SRO) was presented. The On-the-Job Training Manual is composed of a special video of each system that guides the trainee through a specified route in the plant showing the keypoints about the specific system. This Manual includes scanned photos of the main components and very detailed layout drawings to quickly walk-through a system. Two data bases were established to keep track of all the systems and tasks associated with a job post and to maintain the JPMs. SAT application in Spain, Argentina, Novovoronezh (Russia), and Hungary has varied by the time and human resources necessary to develop a complete SAT or a simplified SAT (which omits the taxonomic code for obtaining knowledge and skills associated to each task). An example of simulator training program materials and its correlation with the JPMs was presented along with a simulator evaluation guide showing how to assess RO/SRO behaviour

The training process: Planning for strength–power training in track and field. Part 1: Theoretical aspects

Directory of Open Access Journals (Sweden)

Brad H. DeWeese

2015-12-01

Full Text Available The process of strength–power training and the subsequent adaptation is a multi-factorial process. These factors range from the genetics and morphological characteristics of the athlete to how a coach selects, orders, and doses exercises and loading patterns. Consequently, adaptation from these training factors may largely relate to the mode of delivery, in other words, programming tactics. There is strong evidence that the manner and phases in which training is presented to the athlete can make a profound difference in performance outcome. This discussion deals primarily with block periodization concepts and associated methods of programming for strength–power training within track and field.

Interventional study plan to investigate the training effects on physical and psychological outcomes awareness of smoking in teenagers.

Science.gov (United States)

Mohamadian, Fathola; Baghri, Maryam; Delpisheh, Ali; Veisani, Yousef

2017-01-01

Studies have found that nearly 90% of the first use of tobacco takes place before high school graduation (teenagers) and training discussion due to prevention can be useful, therefore, here, we aimed to determine the effects of training on awareness of cigarette outcomes (physical and psychological) in male teenagers. We conducted an interventional study using Solomon's four-group plan, which used a two-stage cluster sampling in four groups (two experimental groups and two control groups). The three sessions of at least 2 h of education intervention including visual displaying using photo, film, and short scientific texts were held for the interventional group. After 1 month, all four groups took posttest, and research groups were followed up after 8 months of intervention. All data were analyzed using one-way analysis of variance and covariance in SPSS. According to the results, the mean of posttest scores had increased rather than pretest scores, and generally, a significant difference was observed ( P ≤ 0.001). These results were significant in the aspect of both physical and psychological outcomes awareness. The difference between the mean of scores in follow-up period and posttest was not statistically significant, and it shows training retention after 8 months ( P training, it is possible to increase the awareness of teenagers about physical and psychological outcomes of cigarette smoking that this can have an important role in smoking prevention.

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

Science.gov (United States)

Esteller, M; Risques, R A; Toyota, M; Capella, G; Moreno, V; Peinado, M A; Baylin, S B; Herman, J G

2001-06-15

Defects in DNA repair may be responsible for the genesis of mutations in key genes in cancer cells. The tumor suppressor gene p53 is commonly mutated in human cancer by missense point mutations, most of them G:C to A:T transitions. A recognized cause for this type of change is spontaneous deamination of the methylcytosine. However, the persistence of a premutagenic O(6)-methylguanine can also be invoked. This last lesion is removed in the normal cell by the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT). In many tumor types, epigenetic silencing of MGMT by promoter hypermethylation has been demonstrated and linked to the appearance of G to A mutations in the K-ras oncogene in colorectal tumors. To study the relevance of defective MGMT function by aberrant methylation in relation to the presence of p53 mutations, we studied 314 colorectal tumors for MGMT promoter hypermethylation and p53 mutational spectrum. Inactivation of MGMT by aberrant methylation was associated with the appearance of G:C to A:T transition mutations at p53 (Fischer's exact test, two-tailed; P = 0.01). Overall, MGMT methylated tumors displayed p53 transition mutations in 43 of 126 (34%) cases, whereas MGMT unmethylated tumors only showed G:C to A:T changes in 37 of 188 (19%) tumors. A more striking association was found in G:C to A:T transitions in non-CpG dinucleotides; 71% (12 of 17) of the total non-CpG transition mutations in p53 were observed in MGMT aberrantly methylated tumors (Fischer's exact test, two-tailed; P = 0.008). Our data suggest that epigenetic silencing of MGMT by promoter hypermethylation may lead to G:C to A:T transition mutations in p53.

A Greenhouse for Tropical Lowlands (Malaysia), Training manual : Guidelines for the Planning and Organisation of Training Activities

NARCIS (Netherlands)

Elings, A.; Stijger, I.; Blomne Sopov, M.; Campen, J.B.; Runia, L.

2012-01-01

This Training Manual on tropical lowland greenhouse horticulture has been prepared as a manual for training of trainers staff of the Department of Agriculture of Malaysia, agricultural extension workers of the government, trainers of educational institutes engaged in greenhouse training and for

SU-F-T-447: The Impact of Treatment Planning Methods On RapidPlan Modeling for Rectum Cancer

Energy Technology Data Exchange (ETDEWEB)

Lu, S; Peng, J; Li, K; Wang, J; Hu, W [Fudan University Shanghai Cancer Center, Shanghai, Shanghai (China)

2016-06-15

Purpose: To investigate the dose volume histogram (DVH) prediction varieties based on intensity modulate radiotherapy (IMRT) plan or volume arc modulate radiotherapy (VMAT) plan models on the RapidPlan. Methods: Two DVH prediction models were generated in this study, including an IMRT model trained from 83 IMRT rectum plans and a VMAT model trained from 60 VMAT rectum plans. In the internal validation, 20 plans from each training database were selected to verify the clinical feasibility of the model. Then, 10 IMRT plans (PIMRT-by-IMRT-model) generated from IMRT model and 10 IMRT plans generated from VMAT model (PIMRT-by-VMAT-model) were compared on the dose to organs at risk (OAR), which included bladder, left and right femoral heads. The similar comparison was also performed on the VMAT plans generated from IMRT model (PVMAT-by-IMRT-model) and VMAT plans generated from VMAT (PVMAT-by-VMAT-model) model. Results: For the internal validation, all plans from IMRT or VMAT model shows significantly improvement on OAR sparing compared with the corresponded clinical ones. Compared to the PIMRT-by-VMAT-model, the PIMRT-by-IMRT-model has a reduction of 6.90±3.87%(p<0.001) on V40 6.63±3.62%(p<0.001) on V45 and 4.74±2.26%(p<0.001) on V50 in bladder; and a mean dose reduction of 2.12±1.75Gy(p=0.004) and 2.84±1.53Gy(p<0.001) in right and left femoral head, respectively. There was no significant difference on OAR sparing between PVMAT-by-IMRT-model and PVMAT-by-VMAT-model. Conclusion: The IMRT model for the rectal cancer in the RapidPlan can be applied to for VMAT planning. However, the VMAT model is not suggested to use in the IMRT planning. Cautions should be taken that the planning model based on some technique may not feasible to other planning techniques.

Challenging behaviour: an action plan for education and training.

Science.gov (United States)

Farrell, Gerald A; Salmon, Peter

Nurses and other health care staff frequently encounter a range of aggressive and other 'challenging behaviours' at work from clients and colleagues. In response to staff concerns, an abundance of state and national policies are now available but it is left up to individual employers to decide how best to implement them at a local level. In this paper we offer an education and training model which is conceptually sound, practical in application, and suitable for health care staff at different levels in the organisation. The importance of understanding challenging behaviour from an interactional perspective, and the educational principles on which training should be founded, are discussed. Finally, the cost of training and the need for program evaluation are considered.

Implementation of the INEEL safety analyst training standard

International Nuclear Information System (INIS)

Hochhalter, E. E.

2000-01-01

The Idaho Nuclear Technology and Engineering Center (INTEC) safety analysis units at the Idaho National Engineering and Environmental Laboratory (INEEL) are in the process of implementing the recently issued INEEL Safety Analyst Training Standard (STD-1107). Safety analyst training and qualifications are integral to the development and maintenance of core safety analysis capabilities. The INEEL Safety Analyst Training Standard (STD-1107) was developed directly from EFCOG Training Subgroup draft safety analyst training plan template, but has been adapted to the needs and requirements of the INEEL safety analysis community. The implementation of this Safety Analyst Training Standard is part of the Integrated Safety Management System (ISMS) Phase II Implementation currently underway at the INEEL. The objective of this paper is to discuss (1) the INEEL Safety Analyst Training Standard, (2) the development of the safety analyst individual training plans, (3) the implementation issues encountered during this initial phase of implementation, (4) the solutions developed, and (5) the implementation activities remaining to be completed

Can the 'Assessment Drives Learning' effect be detected in clinical skills training? - Implications for curriculum design and resource planning

Science.gov (United States)

Buss, Beate; Krautter, Markus; Möltner, Andreas; Weyrich, Peter; Werner, Anne; Jünger, Jana; Nikendei, Christoph

2012-01-01

Purpose: The acquisition of clinical-technical skills is of particular importance for the doctors of tomorrow. Procedural skills are often trained for the first time in skills laboratories, which provide a sheltered learning environment. However, costs to implement and maintain skills laboratories are considerably high. Therefore, the purpose of the present study was to investigate students’ patterns of attendance of voluntary skills-lab training sessions and thereby answer the following question: Is it possible to measure an effect of the theoretical construct related to motivational psychology described in the literature – ‘Assessment drives learning’ – reflected in patterns of attendance at voluntary skills-lab training sessions? By answering this question, design recommendations for curriculum planning and resource management should be derived. Method: A retrospective, descriptive analysis of student skills-lab attendance related to voluntary basic and voluntary advanced skills-lab sessions was conducted. The attendance patterns of a total of 340 third-year medical students in different successive year groups from the Medical Faculty at the University of Heidelberg were assessed. Results: Students showed a preference for voluntary basic skills-lab training sessions, which were relevant to clinical skills assessment, especially at the beginning and at the end of the term. Voluntary advanced skills-lab training sessions without reference to clinical skills assessment were used especially at the beginning of the term, but declined towards the end of term. Conclusion: The results show a clear influence of assessments on students’ attendance at skills-lab training sessions. First recommendations for curriculum design and resource management will be described. Nevertheless, further prospective research studies will be necessary to gain a more comprehensive understanding of the motivational factors impacting students’ utilisation of voluntary skills

GUIDELINES FOR TRAINING SITUATION ANALYSIS (TSA). FINAL REPORT.

Science.gov (United States)

CHENZOFF, ANDREW P.; FOLLEY, JOHN D., JR.

THESE GUIDELINES REPRESENT A TEXTBOOK FOR INSTRUCTION IN THREE PHASES OF TRAINING SITUATION ANALYSIS (TSA), A STANDARDIZED PROCEDURE DEVELOPED BY THE NAVAL TRAINING DEVICE CENTER FOR SYSTEMATICALLY GATHERING AND INTERPRETING THE INFORMATION RELEVANT TO THE PLANNING OF TRAINING AND TRAINING DEVICES. THREE PHASES OF TSA ARE DESCRIBED IN…

Training Standardization

International Nuclear Information System (INIS)

Agnihotri, Newal

2003-01-01

The article describes the benefits of and required process and recommendations for implementing the standardization of training in the nuclear power industry in the United States and abroad. Current Information and Communication Technologies (ICT) enable training standardization in the nuclear power industry. The delivery of training through the Internet, Intranet and video over IP will facilitate this standardization and bring multiple benefits to the nuclear power industry worldwide. As the amount of available qualified and experienced professionals decreases because of retirements and fewer nuclear engineering institutions, standardized training will help increase the number of available professionals in the industry. Technology will make it possible to use the experience of retired professionals who may be interested in working part-time from a remote location. Well-planned standardized training will prevent a fragmented approach among utilities, and it will save the industry considerable resources in the long run. It will also ensure cost-effective and safe nuclear power plant operation

20 CFR 631.50 - Substate plan.

Science.gov (United States)

2010-04-01

... THE JOB TRAINING PARTNERSHIP ACT Substate Programs § 631.50 Substate plan. (a) In order to receive an...)). (g) If a substate grantee fails to meet the requirements for plan submission and approval found in...

Development of a Training Program for Commercial Building Technicians

Energy Technology Data Exchange (ETDEWEB)

Rinholm, Rod

2013-05-31

This project focused on developing and deploying a comprehensive program of 22 training modules, including certification requirements, and accreditation standards for commercial building technicians, to help achieve the full savings potential of energy efficient buildings, equipment, and systems. This curriculum extended the currently available commercial building technician programs -- training a labor force in a growing market area focused on energy efficiency. The program helps to remove a major market impediment to low energy/zero energy commercial building system acceptance, namely a lack of operating personnel capable of handling more complex high efficiency systems. The project developed a training curriculum for commercial building technicians, with particular focus on high-efficiency building technology, and systems. In Phase 1, the project team worked collaboratively in developing a draft training syllabus to address project objectives. The team identified energy efficiency knowledge gaps in existing programs and plans and plans to address the gaps with either modified or new curricula. In Phase 2, appropriate training materials were developed to meet project objectives. This material was developed for alternative modes of delivery, including classroom lecture materials, e-learning elements, video segments, exercises, and hands-on training elements. A Certification and Accreditation Plan and a Commercialization and Sustainability Plan were also investigated and developed. The Project Management Plan was updated quarterly and provided direction on the management approaches used to accomplish the expected project objectives. GTI project management practices tightly coordinate project activities using management controls to deliver optimal customer value. The project management practices include clear scope definition, schedule/budget tracking, risk/issue resolution and team coordination.

EM Health and Safety Plan Guidelines

Energy Technology Data Exchange (ETDEWEB)

1994-12-01

This document contains information about the Health and Safety Plan Guidelines. Topics discussed include: Regulatory framework; key personnel; hazard assessment; training requirements; personal protective equipment; extreme temperature disorders or conditions; medical surveillance; exposure monitoring/air sampling; site control; decontamination; emergency response/contingency plan; emergency action plan; confined space entry; and spill containment.

O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis

Directory of Open Access Journals (Sweden)

Altamura Gennaro

2012-11-01

Full Text Available Abstract Background Bovine papillomaviruses (BPVs types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to neoplastic skin lesions in equids termed sarcoids. The equine sarcoid is considered to be the most common equine cutaneous tumour worldwide for which no effective therapy is available. Very little is known about the molecular mechanisms underlying tumourigenesis, although genes contributing to sarcoid development have been identified. Several studies associate the development of cancer to the loss of function of a number of oncosuppressor genes. In this study the putative role of O6-methylguanine-DNA methyltrasferase (MGMT was investigated for sarcoids. The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissues. In addition, the DNA methylation profile was analysed to assess the role of epigenetic mechanism in regulation of MGMT expression. Results A group of 15 equine sarcoids and two primary sarcoid cell lines (fibroblasts were analyzed for the expression of MGMT protein by immunohistochemistry, immunofluorescence and Western blotting techniques. The sarcoid cell line EqSO4b and the tumour samples showed a reduction or absence of MGMT expression. To investigate the causes of deregulated MGMT expression, ten samples were analyzed for the DNA methylation profile of the CpG island associated to the MGMT promoter. The analysis of 73 CpGs encompassing the region of interest showed in 1 out of 10 (10% sarcoids a pronouncedly altered methylation profile when compared to the control epidermal sample. Similarily the EqSO4b cell line showed an altered MGMT methylation pattern in comparison to normal fibroblasts. Conclusion As previously demonstrated for the oncosuppressor gene FHIT, analysis of MGMT expression in sarcoid tissues and a sarcoid-derived fibroblast cell line further suggests that

Monju operator training report. Training results and upgrade of the operation training simulator in 2002 YF

International Nuclear Information System (INIS)

Koyagoshi, Naoki; Sasaki, Kazuichi; Sawada, Makoto; Kawanishi, Tomotake; Yoshida, Kazuo

2003-09-01

The prototype fast breeder reactor, Monju, has been performing deliberately the operator training which is composed of the regulated training required by the government and the self-training. The training used a full scope type simulator (MARS: Monju Advanced Reactor Simulator) plays an important role among of the above mentioned trainings and greatly contributes to the Monju operator training for Monju restarting. This report covers the activities of Monju operator training in 2002 FY, i.e. the training results and the remodeling working of the MARS in progress since 1999. (1) Eight simulator training courses were carried out 46 times and 180 trainees participated. Additionally, both the regulated training and self-training were held total 10 times by attended 34 trainees, as besides simulator training. (2) Above training data was reduced compare with the last year's data (69 times (338 trainees)) due to the indispensable training courses in Monju operator training were changed by reorganized operator's number and decreasing of training times owing to remodeling working of the simulator was conducted. (3) By means of upgrading of the MARS completed in 2002 FY, its logic arithmetic time was became speedier and its instructing function was improved remarkably, thus, the simulator training was became to be more effective. Moreover, it's planning to do both remodeling in the next year as the final working: remodeling of reactor core model with the aim of improvement simulating accuracy and corresponding to the sodium leakage measures. Regarding on the Monju training results and simulator's remodeling so far finished, please referring JNC report number of JNC TN 4410 2002-001 Translation of Monju Simulator Training owing Monju Accident and Upgrade of MARS''. (author)

A report on disaster prevention trainings of nuclear energy, in fiscal year 2000

International Nuclear Information System (INIS)

Nomura, Tamotsu; Katagiri, Hiromi; Akiyama, Takashi; Kikuchi, Masayuki

2001-05-01

Trainings on nuclear disaster prevention are often planned and practiced since early times at the nuclear energy relating organizations on many courses. A training carried out in fiscal year 2000 by the Emergent Assistance and Training Center in the Japan Nuclear Cycle Development Institute is decided to a portion on disaster prevention measure at a viewpoint of 'Crisis Management' which is essential element in present disaster prevention measure to fall short at present. In concrete, a crisis management training for nuclear disaster prevention (senior and business courses), an emergent publicity response training, and a disaster prevention training planning training were designed and decided. These trainings were established according to experiences accumulated by inter-company crisis management learning, and were constructed by containing items relating to respective special knowledge, conditions on chemical plants and disaster prevention measure system in U.S.A. and Europe, and so on. Here was described on design and practice of training plan, and practice of the trainings. (G.K)

Training program for energy conservation in new-building construction. Volume IV. Energy conservation technology: advanced course for plan examiners

Energy Technology Data Exchange (ETDEWEB)

None

1977-12-01

A Model Code for Energy Conservation in New Building Construction has been developed by those national organizations primarily concerned with the development and promulgation of model codes. The technical provisions are based on ASHRAE Standard 90-75 and are intended for use by state and local officials. This manual contains a more in-depth training in the review techniques and concepts required by the plan examiners and code officials in administering the code for conventional (buildings of 3 stories or less) construction.

Succession Planning for Library Instruction

Science.gov (United States)

Sobel, Karen; Drewry, Josiah

2015-01-01

Detailed succession planning helps libraries pass information from one employee to the next. This is crucial in preparing for hiring, turnover, retirements, training of graduate teaching assistants in academic libraries, and other common situations. The authors of this article discuss succession planning for instruction programs in academic…

Systematic approach to training. Experiences from the training activities of regulatory body personnel in STUK

Energy Technology Data Exchange (ETDEWEB)

Aro, I.

1998-04-01

The report describes the experiences obtained of a training programme for nuclear power plant inspectors arranged in the 90`s by the Radiation and Nuclear Safety Authority of Finland (STUK). In the implementation of the programme, a systematic method was used to analyse the training needs, to plan, develop and implement the training programme as well as to assess the programme`s implementation and results. The method used, `SAT Ae Systematic Approach to Training`, is presented in `Nuclear Power Plant Personnel Training and its Evaluation, A Guidebook`, IAEA Technical Report Series No. 380, which is a publication of the International Atomic Energy Agency. It is recommended that this method be applied in the planning and implementation of nuclear power plant personnel training. The application of the method as a tool for developing the qualifications of nuclear power plant inspectors shows that the method is well suited for use in Finland. Until the 90`s, STUK had no systematic approach to training activities. Some training was arranged internally, but training in most respects meant participation in external training events and international seminars. A more systematic approach was adopted in the early 90`s. The main goal was to define basic competence profiles for inspectors working in different fields and to provide an internal basic training programme not available externally. The development of the training activities called for a profound renewal of the training function to ensure a systematic approach and high quality. The experiences gained in STUK are useful in co-operation with Eastern and Central European regulatory bodies; they can be utilized when the qualifications of personnel who carry out inspections are developed. This will extensively contribute to the safety of nuclear power plants. (orig.). 2 refs.

Systematic approach to training. Experiences from the training activities of regulatory body personnel in STUK

International Nuclear Information System (INIS)

Aro, I.

1998-04-01

The report describes the experiences obtained of a training programme for nuclear power plant inspectors arranged in the 90's by the Radiation and Nuclear Safety Authority of Finland (STUK). In the implementation of the programme, a systematic method was used to analyse the training needs, to plan, develop and implement the training programme as well as to assess the programme's implementation and results. The method used, 'SAT Ae Systematic Approach to Training', is presented in 'Nuclear Power Plant Personnel Training and its Evaluation, A Guidebook', IAEA Technical Report Series No. 380, which is a publication of the International Atomic Energy Agency. It is recommended that this method be applied in the planning and implementation of nuclear power plant personnel training. The application of the method as a tool for developing the qualifications of nuclear power plant inspectors shows that the method is well suited for use in Finland. Until the 90's, STUK had no systematic approach to training activities. Some training was arranged internally, but training in most respects meant participation in external training events and international seminars. A more systematic approach was adopted in the early 90's. The main goal was to define basic competence profiles for inspectors working in different fields and to provide an internal basic training programme not available externally. The development of the training activities called for a profound renewal of the training function to ensure a systematic approach and high quality. The experiences gained in STUK are useful in co-operation with Eastern and Central European regulatory bodies; they can be utilized when the qualifications of personnel who carry out inspections are developed. This will extensively contribute to the safety of nuclear power plants. (orig.)

21 CFR 120.13 - Training.

Science.gov (United States)

2010-04-01

... CONSUMPTION HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS General Provisions § 120.13 Training... measures, as required by § 120.7. (2) Developing a Hazard Analysis and Critical Control Point (HACCP) plan...) Verifying and modifying the HACCP plan in accordance with the corrective action procedures specified in...

Training Quality: Before and after Winning the Deming Prize.

Science.gov (United States)

Magennis, Jo P.

1995-01-01

Describes the Quality Improvement Program developed by Florida Power and Light's Nuclear Training organization that was awarded the Deming Application Prize for quality control. Training quality, team activities, training's role in business planning, customer involvement and evaluation, and continuous improvement of training are discussed. (LRW)

Comparison of Periodized and Non-Periodized Resistance Training on Maximal Strength: A Meta-Analysis.

Science.gov (United States)

Williams, Tyler D; Tolusso, Danilo V; Fedewa, Michael V; Esco, Michael R

2017-10-01

Periodization is a logical method of organizing training into sequential phases and cyclical time periods in order to increase the potential for achieving specific performance goals while minimizing the potential for overtraining. Periodized resistance training plans are proposed to be superior to non-periodized training plans for enhancing maximal strength. The primary aim of this study was to examine the previous literature comparing periodized resistance training plans to non-periodized resistance training plans and determine a quantitative estimate of effect on maximal strength. All studies included in the meta-analysis met the following inclusion criteria: (1) peer-reviewed publication; (2) published in English; (3) comparison of a periodized resistance training group to a non-periodized resistance training group; (4) maximal strength measured by 1-repetition maximum (1RM) squat, bench press, or leg press. Data were extracted and independently coded by two authors. Random-effects models were used to aggregate a mean effect size (ES), 95% confidence intervals (CIs) and potential moderators. The cumulative results of 81 effects gathered from 18 studies published between 1988 and 2015 indicated that the magnitude of improvement in 1RM following periodized resistance training was greater than non-periodized resistance training (ES = 0.43, 95% CI 0.27-0.58; P training status (β = -0.59; P = 0.0305), study length (β = 0.03; P = 0.0067), and training frequency (β = 0.46; P = 0.0123) were associated with a change in 1RM. These results indicate that undulating programs were more favorable for strength gains. Improvements in 1RM were greater among untrained participants. Additionally, higher training frequency and longer study length were associated with larger improvements in 1RM. These results suggest that periodized resistance training plans have a moderate effect on 1RM compared to non-periodized training plans. Variation in training stimuli

Training programs for emergency response personnel at Hanford

International Nuclear Information System (INIS)

Oscarson, E.E.

1979-01-01

The Three Mile Island reactor accident has focused attention on emergency planning and preparedness including selection and training of personnel. At Hanford, Pacific Northwest Laboratory (PNL) is in the unique position of providing emergency response personnel, planning, training and equipment not only for its own organization and facilities but also for the Hanford Site in general, as well as the Interagency Radiological Assistance Plan (IRAP) Region 8 Team. Team members are chosen for one or more of the emergency teams based upon professional education and/or experience as well as interest, aptitude and specialized knowledge. Consequently, the initial training orientation of each new team member is not directed toward general professional ability, but rather toward specialized knowledge required to carry out their assigned emergency tasks. Continual training and practice is necessary to maintain the interest and skills for effectively coping with major emergencies. The types of training which are conducted include: tests of emergency systems and/or procedures; drills involving plant employees and/or emergency team members (e.g., activation of emergency notification systems); short training sessions on special topics; and realistic emergency exercises involving the simulation of major accidents wherein the emergency team must solve specific problems on a real time basis

PART I: Bioventing Pilot Test Work Plan for Fire Protection Training Area Site FY-03, Charleston AFB, South Carolina. PART II: Draft Interim Pilot Test Results Report for Fire Protection Training Area Site FT-03, Charleston AFB, South Carolina

National Research Council Canada - National Science Library

1993-01-01

This site-specific work plan presents the scope of a bioventing pilot test for in situ treatment of fuel contaminated soils at the Fire Protection Training Area designated as Site FT-O3, Charleston Air Force Base (AFB), South Carolina...

Department of Defense Training Transformation Implementation Plan

National Research Council Canada - National Science Library

2003-01-01

... and noncombat operations. Emphasis has shifted from deliberate to adaptive war planning, and from permanent organizations and large hierarchies to smaller, highly-distributed joint and combined forces and standing joint task...

78 FR 61251 - The National Public Transportation Safety Plan, the Public Transportation Agency Safety Plan, and...

Science.gov (United States)

2013-10-03

...-0030] RIN 2132-AB20; 2132-AB07 The National Public Transportation Safety Plan, the Public Transportation Agency Safety Plan, and the Public Transportation Safety Certification Training Program; Transit... Public Transportation Safety Program (National Safety Program) and the requirements of the new transit...

The nuclear industry in transition: Methods and effects of cross training

International Nuclear Information System (INIS)

Starrett, D.M.; Wilczek, T.A.; Armstrong, D.L.

1996-01-01

As DOE facilities transition from defense programs to environmental management, cross training is becoming increasingly important as an essential component of change management. When applied to those specific segments of nuclear industry undergoing transition, cross training methods can be especially effective. Use of methodologies such as team approach, change agents, strategic plans, operations plans, specific training, and formal transition techniques can generate many positive benefits to the industry. This paper explores the benefits of cross training, proposes methodology for use when developing cross training for the transition of employees from DOE defense programs to environmental projects, and provides two examples of successful implementation of cross training methods

Complex Information Coordination Performance: Differential Changes in Working Memory Contributions Following Training. Cognitive Components of Information Coordination

Science.gov (United States)

1993-06-30

UNIVERSITY DEPARTMENT OF PSYCHOLOGY EDUCATION BUILDING TALLAHASSEE FL 32306 W LAFAYETTE IN 47907 DR NEIL DORANS DR RODNEY COCKING EDUCATIONAL TESTING SERVICE...DR LORRAINE D EYDE PSYCHOLOGY DEPARTMENT US OFFICE OF PERSONNEL MGMT IOWA STATE UNIVERSITY OFFICE OF PERSONNEL RESEARCH AMES IA 50010 AND DEVELOP...judgments were performed under the added cognitive load of the coordination task. Method Subjects A total of eighty subjects were tested , with one

Multifuntional Nanotherapeutics for the Combinatorial Drug and Gene Therapy in the Treatment of Glioblastoma Multiforme

Science.gov (United States)

Hourigan, Breanne

Glioblastoma multiforme (GBM), a grade IV glioma, is the most common primary brain tumor, affecting about 3 out of 100,000 persons per year in the United States. GBM accounts for about 80% of primary malignant brain tumors, and is also the most aggressive of malignant brain tumors. With exhaustive treatment, survival only averages between 12 and 15 months, with a 2-year survival rate less than 25%. New therapeutic strategies are necessary to improve the outcomes of this disease. Chemotherapy with temozolomide (TMZ), a DNA alkylating agent, is used as a first-line of treatment for GBM. However, GBM tumors develop resistance to TMZ over time due to increased expression of O6-methylguanine-DNA methyltransferase (MGMT), a gene responsible for DNA repair. We previously developed cationic, amphiphilic copolymer poly(lactide-co-glycolide)-g-polyethylenimine (PgP) and demonstrated its utility for nucleic acid delivery. Here, we examine the ability of PgP polyplexes to overcome TMZ resistance and improve therapeutic efficacy through combination drug and gene therapy for GBM treatment. In this study, we evaluated the ability of PgP to deliver siRNA targeting to MGMT (siMGMT), a gene responsible for drug resistance in GBM. Our results demonstrated that PgP effectively forms stable complex with siRNA and protects siRNAs from heparin competition assay, serum- and ribonuclease-mediated degradation, confirming the potential of the polyplex for in vivo delivery. Results from MTT assays showed that PgP/siRNA polyplexes exhibited minimal cytotoxicity compared to untreated cells when incubated with T98G human GBM cells. We also demonstrated that PgP/siMGMT polyplexes mediate knockdown of MGMT protein as well as a significant ˜56% and ˜68% knockdown of MGMT mRNA in T98G GBM cells compared to cells treated with PgP complexed with non-targeting siRNA (siNT) at a 60:1 and 80:1 nitrogen:phosphate (N:P) ratio, respectively. Further, co-incubation of PgP/siMGMT polyplexes with TMZ

Health physics training of plant staff

International Nuclear Information System (INIS)

Heublein, R.M. Jr.

1982-01-01

The scope of this document entitled Health Physics Training of Plant Staff addresses those critical elements common to all health physics training programs. The incorporation of these elements in a health physics training program will provide some assurances that the trainees are competent to work in the radiological environment of a nuclear plant. This paper provides sufficient detail for the health physicist to make managerial decisions concerning the planning, development, implementation, and evaluation of health physics training programs. Two models are provided in the appendices as examples of performance based health physics training programs

2005-06 Academic Training Programme Questionnaire

CERN Multimedia

Françoise Benz

2005-01-01

Please help the Academic Training Committee to plan the 2005-06 programme of lectures by filling in the 2005-06 Academic Training Programme Questionnaire which can be found at: http://cern.ch/Academic.Training/questionnaire ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.

PHMC post-NPH emergency response training

International Nuclear Information System (INIS)

Conrads, T.J.

1997-01-01

This document describes post-Natural Phenomena Hazard (NPH) emergency response training that was provided to two teams of Project Hanford Management Contractors (PHMC) staff that will be used to assess potential structural damage that may occur as a result of a significant natural phenomena event. This training supports recent plans and procedures to use trained staff to inspect structures following an NPH event on the Hanford Site

PHMC post-NPH emergency response training

Energy Technology Data Exchange (ETDEWEB)

Conrads, T.J.

1997-04-08

This document describes post-Natural Phenomena Hazard (NPH) emergency response training that was provided to two teams of Project Hanford Management Contractors (PHMC) staff that will be used to assess potential structural damage that may occur as a result of a significant natural phenomena event. This training supports recent plans and procedures to use trained staff to inspect structures following an NPH event on the Hanford Site.

Evaluations of Three Methods for Remote Training

Science.gov (United States)

Woolford, B.; Chmielewski, C.; Pandya, A.; Adolf, J.; Whitmore, M.; Berman, A.; Maida, J.

1999-01-01

Long duration space missions require a change in training methods and technologies. For Shuttle missions, crew members could train for all the planned procedures, and carry documentation of planned procedures for a variety of contingencies. As International Space Station (ISS) missions of three months or longer are carried out, many more tasks will need to be performed for which little or no training was received prior to launch. Eventually, exploration missions will last several years, and communications with Earth will have long time delays or be impossible at times. This series of three studies was performed to identify the advantages and disadvantages of three types of training for self-instruction: video-conferencing; multimedia; and virtual reality. These studies each compared two types of training methods, on two different types of tasks. In two of the studies, the subject's were in an isolated, confined environment analogous to space flight; the third study was performed in a laboratory.

MAXIMIZATION OF DNA DAMAGE TO MGMT(+ EGFR(+ GBM CELLS USING OPTIMAL COMBINATION OF TEMOZOLOMIDE-ANTI EGFR MONOCLONAL ANTIBODY NIMOTUZUMAB

Directory of Open Access Journals (Sweden)

M. A. M. Inggas

2015-09-01

Full Text Available Background: Glioblastoma multiforme (GBM is the most aggressive primary brain tumor in adultswith dismal prognosis due to the unavailability of an effective therapy. Up to now, there had been no definitive studies published on EGFR inhibition therapy as a chemosensitizer for GBM therapy using Temozolomide (TMZ. This study aims to reveal the most effective method and timing to administer TMZ-anti EGFR targeted therapy which causes maximal DNA damage on GBM cells.Methods: Various regimens of anti EGFR monoclonal antibody Nimotuzumab (NMZ was administered in different combinations with TMZ, performed on U87MG MGMT(+ EGFR(+ cells. The effectiveness of the combinations were evaluated by measuring yH2AX levels which reflects the degree of DNA damage. One-way Anova and LSD tests were performed to determine the effects of each treatment with p<0.05. Results and discussion: the mean SD of yH2AX of each treatment was: 11,90±1,25 for the control group; 29.33±1.91 for NMZ alone; 28.13±1.58 for TMZ alone; 41.53±3.51 for concurrent use; 35.67 ±2.65 for NMZ after 24 hours TMZ; 31.87±2.94 for NMZ after 48 hours TMZ; 39.57±4.2 for TMZ after 24 hours NMZ; and 35.93 ±3.56 for TMZ after 48 hours NMZ. The administration of TMZ concurrent with or after 24 hours NMZ gives the highest amount of DNA damage to GBM cells. Conclusion: The administration of Nimotuzumab targeted therapy up to 24 hours before Temozolomide chemotherapy has been proven to be effective in maximizing the amount of DNA damage done to GBM cells in vitro. 

NDE training activities at the EPRI NDE Center

International Nuclear Information System (INIS)

Pherigo, G.L.

1988-01-01

The three principal categories of training activity at the EPRI NDE Center are in-service inspection (ISI) training, technical skills training, and human resource development. The ISI training category, which addresses recently developed NDE technologies that are ready for field application, is divided into two areas. One area provides ongoing training and qualification service to boiling water reactor (BWR) utilities in accordance with the Coordination Plan for NRC/EPRI/BWROG Training and Qualification Activities of NDE Personnel. This plan specifically addresses the detection and sizing of intergranular stress corrosion cracking (IGSCC). The second area includes training activities for other recently developed NDE technologies. Courses in this area include weld overlay examination and advanced eddy current data analysis. The technical skills training is developed and offered to support the basic NDE technology needs of the utilities, with emphasis on utility applications. These programs are provided in direct response to generic or specific needs identified by the utility NDE community. The human resource development activities are focused on long-term utility needs through awareness programs for high schools, technical schools, and universities. These training programs are described

"Part of the Team": Mapping the outcomes of training patients for new roles in health research and planning.

Science.gov (United States)

Shklarov, Svetlana; Marshall, Deborah A; Wasylak, Tracy; Marlett, Nancy J

2017-12-01

A patient research internship (Patient and Community Engagement Research program-PaCER) was created to support a provincial commitment by Alberta Health Services' Strategic Clinical Networks ™ to find new ways to engage patients in a new interdisciplinary organization to support evidence-informed improvements in clinical outcomes across the health system. Implement and test a new research method and training curriculum to build patient capacity for engagement in health through peer-to-peer research. Programme evaluation using Outcome Mapping and the grounded theory method. Twenty-one patients with various chronic conditions completed one year of training in adapted qualitative research methods, including an internship where they designed and conducted five peer-to-peer inquiries into a range of health experiences. Outcomes were continually monitored and evaluated using an Outcome Mapping framework, in combination with grounded theory analysis, based on data from focus groups, observation, documentation review and semi-structured interviews (21 patient researchers, 15 professional collaborators). Key stakeholders indicated the increased capacity of patients to engage in health-care research and planning, and the introduction and acceptance of new, collaborative roles for patients in health research. The uptake of new patient roles in health-care planning began to impact attitudes and practices. Patient researchers become "part of the team" through cultural and relationship changes that occur in two convergent directions: (i) building the capacity of patients to engage confidently in a dialogue with clinicians and decision makers, and (ii) increasing the readiness for patient engagement uptake within targeted organizations. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

Restaurant Training Recipe At Triton College

Science.gov (United States)

Quagliano, Joseph

1974-01-01

The successful restaurant training program at Triton College (Illinois) involves a broadly based, two-year curriculum offering practical training in nearly all the areas associated with a comprehensive food operation--management, food preparation, menu planning, nutrition, personnel vending, dining room service, and cost control. (Author/EA)

ISS Microgravity Research Payload Training Methodology

Science.gov (United States)

Schlagheck, Ronald; Geveden, Rex (Technical Monitor)

2001-01-01

The NASA Microgravity Research Discipline has multiple categories of science payloads that are being planned and currently under development to operate on various ISS on-orbit increments. The current program includes six subdisciplines; Materials Science, Fluids Physics, Combustion Science, Fundamental Physics, Cellular Biology and Macromolecular Biotechnology. All of these experiment payloads will require the astronaut various degrees of crew interaction and science observation. With the current programs planning to build various facility class science racks, the crew will need to be trained on basic core operations as well as science background. In addition, many disciplines will use the Express Rack and the Microgravity Science Glovebox (MSG) to utilize the accommodations provided by these facilities for smaller and less complex type hardware. The Microgravity disciplines will be responsible to have a training program designed to maximize the experiment and hardware throughput as well as being prepared for various contingencies both with anomalies as well as unexpected experiment observations. The crewmembers will need various levels of training from simple tasks as power on and activate to extensive training on hardware mode change out to observing the cell growth of various types of tissue cultures. Sample replacement will be required for furnaces and combustion type modules. The Fundamental Physics program will need crew EVA support to provide module change out of experiment. Training will take place various research centers and hardware development locations. It is expected that onboard training through various methods and video/digital technology as well as limited telecommunication interaction. Since hardware will be designed to operate from a few weeks to multiple research increments, flexibility must be planned in the training approach and procedure skills to optimize the output as well as the equipment maintainability. Early increment lessons learned

Training Educators: Plan for Replicating the Experience

Science.gov (United States)

Mambetakunov, Ulanbek; Ribaudo, Marina

2013-01-01

This paper reports on a short survey and a training course offered to the faculty members of the University of Genova with the aim of driving the users of the university Learning Management System in the transition from Moodle 1.9 to Moodle 2, transition that took place in August 2012. The survey has been administered to lectures and staff to…

20 CFR 628.210 - State Job Training Coordinating Council.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State Job Training Coordinating Council. 628... PROGRAMS UNDER TITLE II OF THE JOB TRAINING PARTNERSHIP ACT State Planning § 628.210 State Job Training Coordinating Council. (a) The Governor shall appoint a State Job Training Coordinating Council (SJTCC) pursuant...

Mesostructure, contemporary training model of the Cuban boxing school

Directory of Open Access Journals (Sweden)

Juan Hernández Sierra

2018-01-01

Full Text Available The present work aims to convey the experiences on the development and application of a meso-structure of 3-4 microcycles that allowed maintaining a long state of the sport form (5-6 months on a scientific-technical and methodological basis in the planning of the Sports training of the national boxing team, who participated in the 4th World Boxing Series (WSB. The investigated sample consisted of 21 boxers, representing 58%, of a population made up of 36 athletes / students belonging to the National School of Boxing. The importance of the research is that it exposes the use of new planning concepts and the current modifications in the training structure, as well as the contribution of science to the adaptation of training loads, which allows to obtain positive results during a long period of time. state of the sport form, factors on which it is necessary to reflect for an effective planning of modern sports training.

Evaluation of plan quality assurance models for prostate cancer patients based on fully automatically generated Pareto-optimal treatment plans.

Science.gov (United States)

Wang, Yibing; Breedveld, Sebastiaan; Heijmen, Ben; Petit, Steven F

2016-06-07

IMRT planning with commercial Treatment Planning Systems (TPSs) is a trial-and-error process. Consequently, the quality of treatment plans may not be consistent among patients, planners and institutions. Recently, different plan quality assurance (QA) models have been proposed, that could flag and guide improvement of suboptimal treatment plans. However, the performance of these models was validated using plans that were created using the conventional trail-and-error treatment planning process. Consequently, it is challenging to assess and compare quantitatively the accuracy of different treatment planning QA models. Therefore, we created a golden standard dataset of consistently planned Pareto-optimal IMRT plans for 115 prostate patients. Next, the dataset was used to assess the performance of a treatment planning QA model that uses the overlap volume histogram (OVH). 115 prostate IMRT plans were fully automatically planned using our in-house developed TPS Erasmus-iCycle. An existing OVH model was trained on the plans of 58 of the patients. Next it was applied to predict DVHs of the rectum, bladder and anus of the remaining 57 patients. The predictions were compared with the achieved values of the golden standard plans for the rectum D mean, V 65, and V 75, and D mean of the anus and the bladder. For the rectum, the prediction errors (predicted-achieved) were only  -0.2  ±  0.9 Gy (mean  ±  1 SD) for D mean,-1.0  ±  1.6% for V 65, and  -0.4  ±  1.1% for V 75. For D mean of the anus and the bladder, the prediction error was 0.1  ±  1.6 Gy and 4.8  ±  4.1 Gy, respectively. Increasing the training cohort to 114 patients only led to minor improvements. A dataset of consistently planned Pareto-optimal prostate IMRT plans was generated. This dataset can be used to train new, and validate and compare existing treatment planning QA models, and has been made publicly available. The OVH model was highly accurate

SU-G-TeP1-07: Investigation of RapidPlan Based Plan Quality for Breast IMRTSimultaneously Integrated Boost

International Nuclear Information System (INIS)

Wang, J; Hu, W; Chen, X; Wu, Z

2016-01-01

Purpose: The aim of this study is to investigate the feasibility of using RapidPlan for breast cancer radiotherapy and to evaluate its performance for planners with different planning experiences. Methods: A training database was collected with 80 expert plan datasets from patients previously received left breast conserving surgery and IMRT-simultaneously integrated boost radiotherapy. The models were created on the RapidPlan. Five patients from the training database and 5 external patients were used for internal and external validation, respectively. Three planners with different planning experiences (beginner, junior, senior) designed manual and RapidPlan based plans for additional ten patients. The plan qualities were compared with manual and RapidPlan based ones. Results: For the internal and external validations, there were no significant dose differences on target coverage for plans from RapidPlan and manual. Also, no difference was found in the mean doses to contralateral breast and lung. The RapidPlan improved the heart (V5, V10, V20, V30, and mead dose) and ipsilateral lung (V5, V10, V20, V30, and mean dose) sparing for the beginner and junior planners. Compare to the plans from senior planner, 6 out of 16 clinically checked parameters were improved in RapidPlan, and the left parameters were similar. Conclusion: It is feasible to generate clinical acceptable plans using RapidPlan for breast cancer radiotherapy. The RapidPlan helps to systematically improve the quality of IMRT plans against the benchmark of clinically accepted plans. The RapidPlan shows promise for homogenizing plan quality by transferring planning expertise from more experienced to less experienced planners.

SU-G-TeP1-07: Investigation of RapidPlan Based Plan Quality for Breast IMRTSimultaneously Integrated Boost

Energy Technology Data Exchange (ETDEWEB)

Wang, J; Hu, W; Chen, X; Wu, Z [Fudan University Shanghai Cancer Center, Shanghai, Shanghai (China)

2016-06-15

Purpose: The aim of this study is to investigate the feasibility of using RapidPlan for breast cancer radiotherapy and to evaluate its performance for planners with different planning experiences. Methods: A training database was collected with 80 expert plan datasets from patients previously received left breast conserving surgery and IMRT-simultaneously integrated boost radiotherapy. The models were created on the RapidPlan. Five patients from the training database and 5 external patients were used for internal and external validation, respectively. Three planners with different planning experiences (beginner, junior, senior) designed manual and RapidPlan based plans for additional ten patients. The plan qualities were compared with manual and RapidPlan based ones. Results: For the internal and external validations, there were no significant dose differences on target coverage for plans from RapidPlan and manual. Also, no difference was found in the mean doses to contralateral breast and lung. The RapidPlan improved the heart (V5, V10, V20, V30, and mead dose) and ipsilateral lung (V5, V10, V20, V30, and mean dose) sparing for the beginner and junior planners. Compare to the plans from senior planner, 6 out of 16 clinically checked parameters were improved in RapidPlan, and the left parameters were similar. Conclusion: It is feasible to generate clinical acceptable plans using RapidPlan for breast cancer radiotherapy. The RapidPlan helps to systematically improve the quality of IMRT plans against the benchmark of clinically accepted plans. The RapidPlan shows promise for homogenizing plan quality by transferring planning expertise from more experienced to less experienced planners.

The IAEA Assistance Training Programme for Transport Security

Energy Technology Data Exchange (ETDEWEB)

Eriksson, Ann-Margret [International Atomic Energy Agency (IAEA); Rawl, Richard R [ORNL; Hawk, Mark B [ORNL; Anderson, Kimberly K [ORNL

2010-01-01

The IAEA Office of Nuclear Security is working cooperatively with the U.S. Department of Energy's Global Threat Reduction Initiative, European Union and Australia to provide transport security assistance to countries throughout the world. Assistance is available to countries in reviewing and upgrading their transport security programs at all levels: (1) National level (regulatory and other government agencies); and (2) Operator level (shippers and carriers). Assistance is directed at implementing a consistent level of security throughout the life cycle of radioactive material (same level of security during transport as when in a fixed facility) Upgrade assistance can include: (1) Expert advisory missions to provide advice and guidance; (2) Training courses for regulatory, governmental and industry personnel; (3) Transport security awareness; (4) Detailed training on designing and implementing transport security programs; (5) Planning to identify and prioritize needs (developing security approaches and plans); (6) Developing model security plans and procedures; and (7) Equipment (vehicles, packages, command and control equipment, etc.). Country visits are now being scheduled to initiate transport security cooperative activities. A training course has been developed to assist countries in developing and implementing transport security programs. The training course has been given as a national training course (three times) and as a Regional training course (three times). The course addresses recommended security provisions for the transport of all radioactive material.

Training for Information Management in a Company.

Science.gov (United States)

Karivalo, Merja

1989-01-01

Argues that information resource management is an established philosophy that needs to be linked to human resources management and strategic planning in industrial companies. A training program for information management is presented, including training objectives, participants, contents, and structure. (CLB)

Radiological emergencies - planning and preparedness

Energy Technology Data Exchange (ETDEWEB)

NONE

1986-12-31

This information and training film in three parts deals with the technical background for emergency planning, emergency planning concepts and emergency preparedness. It describes the technical characteristics of radiological emergencies on which important emergency planning concepts are based and the purpose of those concepts. The film also demonstrates how emergency organizations must work together to ensure adequate preparedness. The programme reflects the standards, guidance and recommendations of the International Atomic Energy Agency

Strategic Planning and the Long-term R&D Plan

International Nuclear Information System (INIS)

Cooley, J.

2015-01-01

The Department of Safeguards of the International Atomic Energy Agency implements a structured strategic planning process to ensure that safeguards will continue to be both effective and efficient in the future. This process provides the Department with a comprehensive and coherent planning framework for the short (2 years), medium (6 years) and long (12 years) term. The Department's suite of planning documents includes a long-term strategic plan and an associated long-term research and development plan as well as a biennial development and implementation support programme. The Department's Long-Term Strategic Plan 2012-2023 addresses the conceptual framework for safeguards implementation, legal authority, technical capabilities (expertise, equipment and infrastructure) and the human and financial resources necessary for Agency verification activities. As research and development (R&D) are essential to meet the safeguards needs of the future, the Department-s Long-Term R&D Plan 2012-2023 is designed to support the Long-Term Strategic Plan 2012-2023 by setting out the capabilities that the Department needs to achieve its strategic objectives, and key milestones towards achieving those capabilities for which Member State R&D support is needed. The Long-Term R&D Plan 2012-2023 addresses the Department's R&D requirements in areas such as safeguards concepts and approaches; detection of undeclared nuclear material and activities; safeguards equipment and communication; information technology, collection, analysis and security; analytical services; new mandates; and training. Long-term capabilities discussed in the presentation include deployed systems (e.g., equipment at facilities); analytical (e.g., sample analysis), operational (e.g., staff expertise and skills) and readiness (e.g., safeguarding new types of facilities) capabilities. To address near-term development objectives and support the implementation of its verification activities as well as to

Training Plan in the Artisanal Processing of Banana as a Productive Activity

Directory of Open Access Journals (Sweden)

Gladys Esther Valencia Navas

2017-05-01

Full Text Available The purpose of this article is centered in the application of a training plan in the artisan processing of the raw material of the cambur like productive activity directed to the farmers of the community El Cobalongo, Altamira Parish of Cáceres Municipio Bolivar, Barinas State. In this sense, the research is oriented under the feasible project modality and will be developed in the following phases: Phase I: Diagnosis, Phase II: Elaboration of the program, Phase III: Feasibility Assessment, Phase IV: Phase V: Evaluation of program impact. The design is field descriptive type so the method to be used is descriptive. The sample will be made up of eighteen (18 producers of cambur of the community mentioned above, to be applied a questionnaire of twenty (20 items, with four alternatives of answer (always, almost always, sometimes and never. The one that will be validated through expert judgment and its reliability will be calculated by calculating the Cronbach alpha coefficient. The data processing will be done as indicated by the criteria to be used for the coding, tabulation and analysis of the information.

MONITORING TRAINING LOADS, STRESS, IMMUNE-ENDOCRINE RESPONSES AND PERFORMANCE IN TENNIS PLAYERS

Directory of Open Access Journals (Sweden)

Rodrigo Vitasovic Gomes

2013-06-01

Full Text Available The study aim was to investigate the effect of a periodised pre-season training plan on internal training load and subsequent stress tolerance, immune-endocrine responses and physical performance in tennis players. Well-trained young tennis players (n = 10 were monitored across the pre-season period, which was divided into 4 weeks of progressive overloading training and a 1-week tapering period. Weekly measures of internal training load, training monotony and stress tolerance (sources and symptoms of stress were taken, along with salivary testosterone, cortisol and immunoglobulin A. One repetition maximum strength, running endurance, jump height and agility were assessed before and after training. The periodised training plan led to significant weekly changes in training loads (i.e. increasing in weeks 3 and 4, decreasing in week 5 and post-training improvements in strength, endurance and agility (P < 0.05. Cortisol concentration and the symptoms of stress also increased in weeks 3 and/or 4, before returning to baseline in week 5 (P < 0.05. Conversely, the testosterone to cortisol ratio decreased in weeks 3 and 4, before returning to baseline in week 5 (P < 0.05. In conclusion, the training plan evoked adaptive changes in stress tolerance and hormonal responses, which may have mediated the improvements in physical performance.

Training Program in Biostatistics for Breast Cancer Research

National Research Council Canada - National Science Library

Little, Roderick

1998-01-01

The current training program terminates in the summer of 1998. We had originally planned to develop a training program in biostatistics for cancer research for submission to the National Cancer Institute (Task 9...

Dynamics of general and specially trained of women-weightlifters at the stage of specialized basic training

Directory of Open Access Journals (Sweden)

Viktor Slobodyanuk

2015-04-01

Full Text Available Purpose: to determine the dynamics of the general and special training of women-weightlifters different groups weight categories for annual macrocycle at the stage of specialized basic training. Materials and Methods: indexes long jump, running 30 meters, push-ups, jumps on how Abalakova index and wrist strength athletes different schools of Ukraine. Results: found dynamic indicators of general and special training of women-weightlifters different groups weight categories at the stage of basic training six specialized schools in Ukraine. Conclusions: the results of the study provide an opportunity to consider certain indicators in planning differentiated training programs to improve the training process athletes for women-weightlifters at the stage of specialized basic training different groups weight categories in the annual macrocycle.

Making training decisions proactively

International Nuclear Information System (INIS)

Hartman, R.F.

1988-01-01

The challenge of making training decisions with a high degree of confidence as to the results of those decisions face every DOD, Federal, State, and City agency. Training has historically been a very labor and paper intensive system with limited automation support. This paper outlines how one DOD component, the Air Force, is approaching that challenge. The Training Decision System (TDS) will provide the Air Force with an automated decision aid to help plan and estimate the consequences of various mixes of resident training, On-The-Job Training (OJT), and field training within a specialty such as security. The system described provides training from enlistment to separation and responds to hundreds of related security task needs. This system identifies what the tasks are, who should provide the training, what training setting should be used, what proficiency should be achieved, and through computer modeling provides an assessment of training effectiveness options and estimate the impact of implementing those options. With current budgetary constraints and with the possibility of further reductions in the future, the most cost effective training mix must be found to sustain required capabilities

Training scientist from developing countries

International Nuclear Information System (INIS)

Schultze-Kraft, P.

1987-01-01

The system of the training of specialists at the IAEA training courses, which are organized on interregional, regional and national basis, is presented. The necessity in the training of specialists in the given field, which is expressed by the states asking for assistance, is the main criterion for choosing subjects at the training courses. The IAEA has concentrated its attention on the courses in the following three directions: courses on the planning (expansion of power systems, prediction of needs in electric power); courses on the supervision (project realization, safety and reliability of NPP operation, radiation protection); courses for NPP construction inspectors, site selection, safety assessment. Training of teachers for national personnel is one of the new directions

O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction

International Nuclear Information System (INIS)

Brell, Marta; Ibáñez, Javier; Tortosa, Avelina

2011-01-01

The DNA repair protein O 6 -Methylguanine-DNA methyltransferase (MGMT) confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction (MSP) the most commonly used for promoter methylation study, while immunohistochemistry (IHC) has become the most frequently used for the detection of MGMT protein expression. Agreement on the best and most reliable technique for evaluating MGMT status remains unsettled. The aim of this study was to perform a systematic review and meta-analysis of the correlation between IHC and MSP. A computer-aided search of MEDLINE (1950-October 2009), EBSCO (1966-October 2009) and EMBASE (1974-October 2009) was performed for relevant publications. Studies meeting inclusion criteria were those comparing MGMT protein expression by IHC with MGMT promoter methylation by MSP in the same cohort of patients. Methodological quality was assessed by using the QUADAS and STARD instruments. Previously published guidelines were followed for meta-analysis performance. Of 254 studies identified as eligible for full-text review, 52 (20.5%) met the inclusion criteria. The review showed that results of MGMT protein expression by IHC are not in close agreement with those obtained with MSP. Moreover, type of tumour (primary brain tumour vs others) was an independent covariate of accuracy estimates in the meta-regression analysis beyond the cut-off value. Protein expression assessed by IHC alone fails to reflect the promoter methylation status of MGMT. Thus, in attempts at clinical diagnosis the two methods seem to select different groups of patients and should not be used interchangeably

Turkish experience with the use of IAEA planning models

International Nuclear Information System (INIS)

Fikret, H.

1997-01-01

Most of the IAEA planning methodologies for energy and electricity planning have been transferred to Turkey as part of Technical Co-operation projects on the subject matter. The transfer has been supplemented by adequate training to national experts through their participation in the above projects and in the training courses on these models organized by the IAEA. The experience gathered in the use of these models in Turkey is described in this paper, highlighting how the models are imbedded in the country's planning procedure for energy and electricity matters. (author). 7 figs, 6 tabs

Turkish experience with the use of IAEA planning models

Energy Technology Data Exchange (ETDEWEB)

Fikret, H [Ministry of Energy and Natural Resouces, Ankara (Turkey)

1997-09-01

Most of the IAEA planning methodologies for energy and electricity planning have been transferred to Turkey as part of Technical Co-operation projects on the subject matter. The transfer has been supplemented by adequate training to national experts through their participation in the above projects and in the training courses on these models organized by the IAEA. The experience gathered in the use of these models in Turkey is described in this paper, highlighting how the models are imbedded in the country`s planning procedure for energy and electricity matters. (author). 7 figs, 6 tabs.

CERN Technical Training : Vista !

CERN Multimedia

HR Department

2009-01-01

Are you running Vista on your new PC – or are you planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual session of this course will take place on 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

CERN Technical Training : Vista !

CERN Multimedia

HR Department

2008-01-01

Are you running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at Technical.Training@cern.ch

CERN Technical Training : Vista !

CERN Multimedia

HR Department

2008-01-01

You are running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

CERN Technical Training : Vista !

CERN Multimedia

HR Department

2008-01-01

Are you running Vista on your new PC – or are you planning to install it? The Technical Training service is organizing a half-day training course on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced in the use of Windows XP. The next bilingual sessions of this course will take place on 12 December 2008 and 30 January 2009. Register using our catalogue: http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at mailto:Technical.Training@cern.ch

CERN Technical Training : Vista !

CERN Multimedia

HR Department

2008-01-01

You are running Vista on your new PC – or are planning to install it? The Technical Training service is organizing a half-day training on the new features of the VISTA operating system. This course introduces the new interfaces and presents the new functionalities for people who are experienced using Windows XP. The next bilingual sessions of this course will take place on December 12, 2008 and January 30, 2009. Register using our catalogue : http://cta.cern.ch/cta2/f?p=110:9 or contact us with your questions/comments at Technical.Training@cern.ch

Connected vehicle impacts on transportation planning technical memorandum #6: skills and expertise required to incorporate connected vehicles into transportation planning.

Science.gov (United States)

2016-02-08

Professional development and training are essential to the incorporation of connected/automated vehicles (C/AV) into the : transportation planning process. In order to guarantee a successful deployment, transportation planning agencies and their : st...

Training Effectiveness Assessment of Red Cape: Crisis Action Planning and Execution

National Research Council Canada - National Science Library

Schaefer, Peter S; Shadrick, Scott B; Beaubien, Jeff; Crabb, Brian T

2008-01-01

.... The training program was assessed in workshops conducted with the Army National Guard. Quantitative data indicate that cognitive performances, reflected in both independent and self assessments, improves as a function of training...

Maternal-Newborn and Surgical Nurses’ Perceptions of Professional Autonomy During the Development of Shared Governance

Science.gov (United States)

1993-01-01

dependent, and deferent beings--hardly characteristics associated with autonomy. Despite the emergence of the feminist movement, these stereotypes...recently, most women have not had occupational roles. Even though Erikson’s model does not stand well from a feminist perspective, many women define...patient clnc.perinetal clinic. AKU. IVF) g. suep"" Nurse Regisry h. Other (MA. Oiech Planning, Ed. Coord.. Adm. Mgmt. Shift Manager. IV Therapy

The training of the operation personnel

International Nuclear Information System (INIS)

Martin, H.D.

1975-01-01

A survey about training places and the volume of the training program for reactor personnel in the Federal Republic of Germany is given. Paragraph 7 of the atomic energy act, which imposes on the operators of nuclear energy plants the qualifired training of the personnel, is refered to. Positive experiences with the use of simulation equipment for training have led to the planning of a simulator-centre which is expected to be ready for operation in 1977. The versatile program of this centre is briefly reported. (ORU) [de

General medicine vs subspecialty career plans among internal medicine residents.

Science.gov (United States)

West, Colin P; Dupras, Denise M

2012-12-05

Current medical training models in the United States are unlikely to produce sufficient numbers of general internists and primary care physicians. Differences in general internal medicine (GIM) career plans between internal medicine residency program types and across resident demographics are not well understood. To evaluate the general medicine career plans of internal medicine residents and how career plans evolve during training. A study of US internal medicine residents using an annual survey linked to the Internal Medicine In-Training Examination taken in October of 2009-2011 to evaluate career plans by training program, sex, and medical school location. Of 67,207 US eligible categorical and primary care internal medicine residents, 57,087 (84.9%) completed and returned the survey. Demographic data provided by the National Board of Medical Examiners were available for 52,035 (77.4%) of these residents, of whom 51,390 (76.5%) responded to all survey items and an additional 645 (1.0%) responded to at least 1 survey item. Data were analyzed from the 16,781 third-year residents (32.2%) in this sample. Self-reported ultimate career plans of internal medicine residents. A GIM career plan was reported by 3605 graduating residents (21.5%). A total of 562 primary care program (39.6%) and 3043 categorical (19.9%) residents reported GIM as their ultimate career plan (adjusted odds ratio [AOR], 2.76; 99% CI, 2.35-3.23; P international medical graduates (22.0% vs 21.1%, respectively; AOR, 1.76; 99% CI, 1.50-2.06; P international medical graduates (57.3% vs 27.3%, respectively; AOR, 3.48; 99% CI, 2.58-4.70; P internal medicine residents, including those in primary care training programs, and differed according to resident sex, medical school location, and program type.

Applying radiological emergency planning experience to hazardous materials emergency planning within the nuclear industry

International Nuclear Information System (INIS)

Foltman, A.; Newsom, D.; Lerner, K.

1988-01-01

The nuclear industry has extensive radiological emergency planning (REP) experience that is directly applicable to hazardous materials emergency planning. Recently, the Feed Materials Production Center near Cincinnati, Ohio, successfully demonstrated such application. The REP experience includes conceptual bases and standards for developing plans that have been tested in hundreds of full-scale exercises. The exercise program itself is also well developed. Systematic consideration of the differences between chemical and radiological hazards shows that relatively minor changes to the REP bases and standards are necessary. Conduct of full-scale, REP-type exercises serves to test the plans, provide training, and engender confidence and credibility

Breastfeeding. COTALMA: training health professionals.

Science.gov (United States)

Casanovas, M C

1994-01-01

The Comite Tecnico de Apoyo a la Lactancia Materna (COTALMA), the Technical Breastfeeding Support Committee, was founded in Bolivia in 1989. It is financed by the United States Agency for International Development (USAID) and the United Nations Children's Fund (UNICEF). It is administered in coordination with the Ministry of Health (MOH). MOH and UNICEF choose the hospitals, who send teams that include a pediatrician, a gynecologist, a nurse, and a nutritionist. The first phase of the course (5.5 days) covers the scientific background of breastfeeding. A baseline study is then planned and conducted at each hospital. 2 to 3 months later, the second phase takes place during which data is presented and breast feeding programs are developed for each hospital. Communication, training, counseling, and planning and evaluation are covered. Practicums are conducted at hospitals. Trainers are usually members of COTALMA. The person in charge of maternal and child health services at MOH lectures on national health policies concerning mothers and children. Training includes use of the national health card, breastfeeding and child survival, and breastfeeding as a family planning method. Culturally appropriate course materials, which are in Spanish, are adapted from those developed by Wellstart International. Articles by COTALMA members and others are added. Participants are encouraged to train all staff at their institutions.

Lessons Learned from an International e-Training

International Nuclear Information System (INIS)

Han, K. W.; Hwang, I. A.; Min, B. J.; Lee, E. J.; Kwon, S. J.

2008-01-01

The Nuclear Training and Education Center (NTC) of KAERI is actively participating in the IAEA's Asian Network for Education in Nuclear Technology (ANENT), focusing on web-based nuclear education and training. The center has contributed, in particular, to the development of the ANENT web-portal including cyber platform, and making relevant courses available on it. As part of this effort, the first e-training was attempted with a course on energy planning jointly by NTC of KAERI, and Planning and Economic Studies Section (PESS) and Nuclear Knowledge Management Section (NKM) of IAEA. The objective of the e-training was: - to introduce the use of an IAEA model named as SIMPACTS (Simplified approach for estimating environmental impacts from electricity generation) for assessing environmental impacts from various electricity generations; - to identify real problems as they are and consider solutions for an effective implementation of e-training courses. SIMPACTS deals with sub-programs, i.e. AirPacts for a non-radiological air pollution, NukPacts for a radiological air pollution, HydroPacts for project impacts, and LiquidPacts for a radiological water pollution. This paper discusses lessons learned from the perspective of the e-training host and an ANENT member

The development and piloting of the REnal specific Advanced Communication Training (REACT) programme to improve Advance Care Planning for renal patients.

Science.gov (United States)

Bristowe, Katherine; Shepherd, Kate; Bryan, Liz; Brown, Heather; Carey, Irene; Matthews, Beverley; O'Donoghue, Donal; Vinen, Katie; Murtagh, Fliss E M

2014-04-01

In recent years, the End-Stage Kidney Disease population has increased and is ever more frail, elderly and co-morbid. A care-focused approach needs to be incorporated alongside the disease focus, to identify those who are deteriorating and improve communication about preferences and future care. Yet many renal professionals feel unprepared for such discussions. To develop and pilot a REnal specific Advanced Communication Training (REACT) programme to address the needs of End-Stage Kidney Disease patients and renal professionals. Two-part study: (1) development of the REnal specific Advanced Communication Training programme informed by multi-professional focus group and patient survey and (2) piloting of the programme. The REnal specific Advanced Communication Training programme was piloted with 16 participants (9 renal nurses/health-care assistants and 7 renal consultants) in two UK teaching hospitals. The focus group identified the need for better information about end-of-life phase, improved awareness of patient perspectives, skills to manage challenging discussions, 'hands on' practice in a safe environment and follow-up to discuss experiences. The patient survey demonstrated a need to improve communication about concerns, treatment plans and decisions. The developed REnal specific Advanced Communication Training programme was acceptable and feasible and was associated with a non-significant increase in confidence in communicating about end-of-life issues (pre-training: 6.6/10, 95% confidence interval: 5.7-7.4; post-training: 6.9/10, 95% confidence interval: 6.1-7.7, unpaired t-test - p = 0.56), maintained at 3 months. There is a need to improve end-of-life care for End-Stage Kidney Disease patients, to enable them to make informed decisions about future care. Challenges include prioritising communication training among service providers.

SAT for NPP personnel training in Spain

International Nuclear Information System (INIS)

Gonzalez, M.

1995-01-01

The SAT process objectives as applied to Spanish NPPs are: Perform JTA for selected job positions at the NPPs; develop the associated training plans; develop training support media; prepare training instructors as teachers and as task analysts; develop a SAT database. A lesson-learned from the task assessments conducted at Spanish NPPs is that the final task list should be obtained with full participation of workers so that they feel the final training plan has been developed taking into account their own opinion and experience. The breakdown of the tasks into its elements and the concordant job performance measure was presented. The process of determining knowledge and skills associated with the task elements and the structure and use of the taxonomy codes (for component, system, and academic skills and knowledge) was shown and explained. Based on the Spanish experience, the average time devoted to analyze a complete task is 5.33 person-hours per task. This data has permitted training and plant management to allocate the NPP human resources to support the analysis phase of SAT (which can be very time-consuming)

Training Services Site Support Program Plan WBS 6.13. Revision 1

International Nuclear Information System (INIS)

1995-09-01

The mission of Hanford Reservation's Training Services is to procure, promote, and provide ''Tomorrow's Training Today'' by innovatively adapting services to meet the needs of current programs. The program objectives are: provide the workforce with the knowledge and skills to safely and effectively achieve the Hanford Mission; Provide customer-driven training services in a quality, cost efficient manner; provide the Hanford community retraining opportunities consistent with the Hanford Mission and Columbia Basin economic viability; and provide workforce with knowledge and expertise with new and more effective technology

Procedural specificity in laparoscopic simulator training

DEFF Research Database (Denmark)

Bjerrum, Flemming; Sørensen, Jette Led; Konge, Lars

2014-01-01

. The secondary outcome is the total training time to proficiency. The improvement in motor skills and effect on cognitive load are also explored. DISCUSSION: The results of this trial might provide new knowledge on how the technical part of surgical training curricula should be comprised in the future......BACKGROUND: The use of structured curricula for minimally invasive surgery training is becoming increasingly popular. However, many laparoscopic training programs still use basic skills and isolated task training, despite increasing evidence to support the use of training models with higher...... functional resemblance, such as whole procedural modules. In contrast to basic skills training, procedural training involves several cognitive skills such as elements of planning, movement integration, and how to avoid adverse events. The objective of this trial is to investigate the specificity...

Findings from Survey Administered to Weatherization Training Centers

Energy Technology Data Exchange (ETDEWEB)

Conlon, Brian [Univ. of Tennessee, Knoxville, TN (United States); Tonn, Bruce Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2015-03-01

This report summarizes results of a survey administered to directors of weatherization training centers that receive funding from the U.S. Department of Energy. The survey presents results related to questions on training offered and future plans.

Caracterización del mercado en un plan de negocios para empresa de capacitación en e-learning - Market characterization in a business plan for an e-learning training company

Directory of Open Access Journals (Sweden)

Rocío Zairet Azuaje Contreras

2017-07-01

Full Text Available Hoy en día, la actualización empresarial es vital, ya que implica la adquisición y mejoramiento de competencias de acuerdo a las funciones del empleado en una organización. El presente artículo tiene como objetivo principal, caracterizar el mercado para la elaboración de un plan de negocios en la creación de una empresa de capacitación outsourcing basada en el E-Learning. En este sentido esta investigación descriptiva con diseño de campo empleó la técnica de la encuesta para determinar lo anteriormente planteado. Entre los hallazgos encontrados, se muestra la falta de incentivo en el adiestramiento de los empleados por parte de los directivos, a pesar de los recursos existentes, que muchos prefieren utilizar para aspectos operativos de la empresa. Sin embargo, hay un grupo dispuesto a recibir este tipo de capacitación, cuyas áreas de conocimiento mayormente demandadas son: área gerencial, Recursos Humanos y habilidades directivas. A manera de conclusión, una vez conocido lo anterior, se podrán plantear alternativas de solución, siendo el caso particular una empresa que ofrezca servicios de formación virtual Summary Today, business upgrading is vital as it involves the competencies acquiring and improving according to the employee’s roles in an organization. This article´s main objective is to characterize the market for the elaboration of a business plan in the creation of a training outsourcing enterprise based on the E-Learning. In this sense this descriptive research with field design used the technique of survey to determine what was previously proposed. Among the findings, there is a lack of incentive in the employees training given by managers, despite the existing resources, which many prefer to use for operational aspects of the company. However, there is a group willing to receive this kind of training, whose mainly demanded knowledge areas are: managerial area, Human Resources and managerial skills. In conclusion

The theory of planned behaviour in medical education: a model for integrating professionalism training.

Science.gov (United States)

Archer, Ray; Elder, William; Hustedde, Carol; Milam, Andrea; Joyce, Jennifer

2008-08-01

Teaching and evaluating professionalism remain important issues in medical education. However, two factors hinder attempts to integrate curricular elements addressing professionalism into medical school training: there is no common definition of medical professionalism used across medical education, and there is no commonly accepted theoretical model upon which to integrate professionalism into the curriculum. This paper proposes a definition of professionalism, examines this definition in the context of some of the previous definitions of professionalism and connects this definition to the attitudinal roots of professionalism. The problems described above bring uncertainty about the best content and methods with which to teach professionalism in medical education. Although various aspects of professionalism have been incorporated into medical school curricula, content, teaching and evaluation remain controversial. We suggest that intervening variables, which may augment or interfere with medical students' implementation of professionalism knowledge, skills and, therefore, attitudes, may go unaddressed. We offer a model based on the theory of planned behaviour (TPB), which describes the relationships of attitudes, social norms and perceived behavioural control with behaviour. It has been used to predict a wide range of behaviours, including doctor professional behaviours. Therefore, we propose an educational model that expands the TPB as an organisational framework that can integrate professionalism training into medical education. We conclude with a discussion about the implications of using this model to transform medical school curricula to develop positive professionalism attitudes, alter the professionalism social norms of the medical school and increase students' perceived control over their behaviours.

Out of the sandbox - cohesive dragline planning

Energy Technology Data Exchange (ETDEWEB)

Cobcroft, T. [Marston & Marston Inc., St Louis, MO (United States)

2008-01-15

Since 1983, Southern Illinois University Carbondale (SIUC), through the Coal Research Center in Carterville, Illinois, has been engaged in operator, engineer, supervisor and manager training in the foundations, plan formulation, iteration and improvement in efficiency of dragline planning and operations. 3d-Dig is a 3-D modeling package used in SIUC's training program to simulate digging and dumping from truck-shovel, dozer-push and dragline operations. SIUC has a scale model dragline and dragline simulator available to assist course attendees with standard dig progressions and optimizing operator technique. 1 fig., 6 photos.

Training at a faith-based institution matters for obstetrics and gynecology residents: results from a regional survey.

Science.gov (United States)

Guiahi, Maryam; Westhoff, Carolyn L; Summers, Sondra; Kenton, Kimberly

2013-06-01

Prior data suggest that opportunities in family planning training may be limited during obstetrics and gynecology (Ob-Gyn) residency training, particularly at faith-based institutions with moral and ethical constraints, although this aspect of the Ob-Gyn curriculum has not been formally studied to date. We compared Ob-Gyn residents' self-rated competency and intentions to provide family planning procedures at faith-based versus those of residents at non-faith-based programs. We surveyed residents at all 20 Ob-Gyn programs in Illinois, Indiana, Iowa, and Wisconsin from 2008 to 2009. Residents were queried about current skills and future plans to perform family planning procedures. We examined associations based on program and residents' personal characteristics and performed multivariable logistic regression analysis. A total of 232 of 340 residents (68%) from 17 programs (85%) returned surveys. Seven programs were faith-based. Residents from non-faith-based programs were more likely to be completely satisfied with family planning training (odds ratio [OR]  =  3.4, 95% confidence limit [CI], 1.9-6.2) and to report they "understand and can perform on own" most procedures. Most residents, regardless of program type, planned to provide all surveyed family planning services. Despite similar intentions to provide family planning procedures after graduation, residents at faith-based training programs were less satisfied with their family planning training and rate their ability to perform family planning services lower than residents at non-faith-based training programs.

2006-2007 Academic Training Programme Questionnaire

CERN Multimedia

Françoise Benz

2006-01-01

Please help the Academic Training Committee to plan the 2006-07 programme of lectures by filling in the 2006-07 Academic Training Programme Questionnaire, which can be found at: http://academia.web.cern.ch/academia/questionnaire/ If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training'form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received.

The relationships between internal and external training load models during basketball training.

Science.gov (United States)

Scanlan, Aaron T; Wen, Neal; Tucker, Patrick S; Dalbo, Vincent J

2014-09-01

The present investigation described and compared the internal and external training loads during basketball training. Eight semiprofessional male basketball players (mean ± SD, age: 26.3 ± 6.7 years; stature: 188.1 ± 6.2 cm; body mass: 92.0 ± 13.8 kg) were monitored across a 7-week period during the preparatory phase of the annual training plan. A total of 44 total sessions were monitored. Player session ratings of perceived exertion (sRPE), heart rate, and accelerometer data were collected across each training session. Internal training load was determined using the sRPE, training impulse (TRIMP), and summated-heart-rate-zones (SHRZ) training load models. External training load was calculated using an established accelerometer algorithm. Pearson product-moment correlations with 95% confidence intervals (CIs) were used to determine the relationships between internal and external training load models. Significant moderate relationships were observed between external training load and the sRPE (r42 = 0.49, 95% CI = 0.23-0.69, p external training load and the SHRZ model (r42 = 0.61, 95% CI = 0.38-0.77, p internal and external training load models, the magnitude of the correlations and low commonality suggest that internal training load models measure different constructs of the training process than the accelerometer training load model in basketball settings. Basketball coaching and conditioning professionals should not assume a linear dose-response between accelerometer and internal training load models during training and are recommended to combine internal and external approaches when monitoring training load in players.

Train shunting at a workshop area

DEFF Research Database (Denmark)

Jacobsen, Per Munk; Pisinger, David

2011-01-01

We consider the problem of planning the shunting of train units at a railway workshop area. Before and after the maintenance check, a train unit is parked at a depository track. The problem is to schedule the trains to workshops and depot tracks in order to complete the repairs as soon as possibl....... It turns out, that both GLS and SA find within a few minutes solutions that are a few percent from the best MIP solution found....

Grader Operator. Open Pit Mining Job Training Series.

Science.gov (United States)

Savilow, Bill

This training outline for grader operators, one in a series of eight outlines, is designed primarily for company training foremen or supervisors and for trainers to use as an industry-wide guideline for heavy equipment operator training in open pit mining in British Columbia. Intended as a guide for preparation of lesson plans both for classroom…

Measuring Training ROI: Silver Bullet or Urban Legend

Science.gov (United States)

2008-06-01

TSRD Doc NAWC Training Systems Division. Training Systems Requirements Analysis Webpage, 30 August 2007 Training System Plan Engineering Specs...QUESTIONNAIRES PERFORMANCE CONTRACTING MONITORING MEASURES OF EFFECTIVENESS 1-X: MSN EFFECTIVENESS (OUTPUT-ORIENTED) e.g.: SAFETY ENVIROMENTAL IMPACT...All costs required to research and develop a system before committing it to production ( engineering design, manufacturing of test articles, testing

Shovel Operator. Open Pit Mining Job Training Series.

Science.gov (United States)

Hartley, Larry

This training outline for shovel operators, one in a series of eight outlines, is designed primarily for company training foremen or supervisors and for trainers to use as an industry-wide guideline for heavy equipment operator training in open pit mining in British Columbia. Intended as a guide for preparation of lesson plans both for classroom…

Networked simulation for team training of Space Station astronauts, ground controllers, and scientists - A training and development environment

Science.gov (United States)

Hajare, Ankur R.; Wick, Daniel T.; Bovenzi, James J.

1991-01-01

The purpose of this paper is to describe plans for the Space Station Training Facility (SSTF) which has been designed to meet the envisioned training needs for Space Station Freedom. To meet these needs, the SSTF will integrate networked simulators with real-world systems in five training modes: Stand-Alone, Combined, Joint-Combined, Integrated, and Joint-Integrated. This paper describes the five training modes within the context of three training scenaries. In addition, this paper describes an authoring system which will support the rapid integration of new real-world system changes in the Space Station Freedom Program.

40 CFR 763.93 - Management plans.

Science.gov (United States)

2010-07-01

... implementation in a timely fashion. (d) Each local education agency shall maintain and update its management plan... surveillance and training. (12) With respect to each consultant who contributed to the management plan, the name of the consultant and one of the following statements: (i) If the State has adopted a contractor...

Dynamic sensorimotor planning during long-term sequence learning: the role of variability, response chunking and planning errors.

Science.gov (United States)

Verstynen, Timothy; Phillips, Jeff; Braun, Emily; Workman, Brett; Schunn, Christian; Schneider, Walter

2012-01-01

Many everyday skills are learned by binding otherwise independent actions into a unified sequence of responses across days or weeks of practice. Here we looked at how the dynamics of action planning and response binding change across such long timescales. Subjects (N = 23) were trained on a bimanual version of the serial reaction time task (32-item sequence) for two weeks (10 days total). Response times and accuracy both showed improvement with time, but appeared to be learned at different rates. Changes in response speed across training were associated with dynamic changes in response time variability, with faster learners expanding their variability during the early training days and then contracting response variability late in training. Using a novel measure of response chunking, we found that individual responses became temporally correlated across trials and asymptoted to set sizes of approximately 7 bound responses at the end of the first week of training. Finally, we used a state-space model of the response planning process to look at how predictive (i.e., response anticipation) and error-corrective (i.e., post-error slowing) processes correlated with learning rates for speed, accuracy and chunking. This analysis yielded non-monotonic association patterns between the state-space model parameters and learning rates, suggesting that different parts of the response planning process are relevant at different stages of long-term learning. These findings highlight the dynamic modulation of response speed, variability, accuracy and chunking as multiple movements become bound together into a larger set of responses during sequence learning.

Knowledge-based prediction of plan quality metrics in intracranial stereotactic radiosurgery

Energy Technology Data Exchange (ETDEWEB)

Shiraishi, Satomi; Moore, Kevin L., E-mail: kevinmoore@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California 92093 (United States); Tan, Jun [Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75490 (United States); Olsen, Lindsey A. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63110 (United States)

2015-02-15

Purpose: The objective of this work was to develop a comprehensive knowledge-based methodology for predicting achievable dose–volume histograms (DVHs) and highly precise DVH-based quality metrics (QMs) in stereotactic radiosurgery/radiotherapy (SRS/SRT) plans. Accurate QM estimation can identify suboptimal treatment plans and provide target optimization objectives to standardize and improve treatment planning. Methods: Correlating observed dose as it relates to the geometric relationship of organs-at-risk (OARs) to planning target volumes (PTVs) yields mathematical models to predict achievable DVHs. In SRS, DVH-based QMs such as brain V{sub 10Gy} (volume receiving 10 Gy or more), gradient measure (GM), and conformity index (CI) are used to evaluate plan quality. This study encompasses 223 linear accelerator-based SRS/SRT treatment plans (SRS plans) using volumetric-modulated arc therapy (VMAT), representing 95% of the institution’s VMAT radiosurgery load from the past four and a half years. Unfiltered models that use all available plans for the model training were built for each category with a stratification scheme based on target and OAR characteristics determined emergently through initial modeling process. Model predictive accuracy is measured by the mean and standard deviation of the difference between clinical and predicted QMs, δQM = QM{sub clin} − QM{sub pred}, and a coefficient of determination, R{sup 2}. For categories with a large number of plans, refined models are constructed by automatic elimination of suspected suboptimal plans from the training set. Using the refined model as a presumed achievable standard, potentially suboptimal plans are identified. Predictions of QM improvement are validated via standardized replanning of 20 suspected suboptimal plans based on dosimetric predictions. The significance of the QM improvement is evaluated using the Wilcoxon signed rank test. Results: The most accurate predictions are obtained when plans are

Knowledge-based prediction of plan quality metrics in intracranial stereotactic radiosurgery

International Nuclear Information System (INIS)

Shiraishi, Satomi; Moore, Kevin L.; Tan, Jun; Olsen, Lindsey A.

2015-01-01

Purpose: The objective of this work was to develop a comprehensive knowledge-based methodology for predicting achievable dose–volume histograms (DVHs) and highly precise DVH-based quality metrics (QMs) in stereotactic radiosurgery/radiotherapy (SRS/SRT) plans. Accurate QM estimation can identify suboptimal treatment plans and provide target optimization objectives to standardize and improve treatment planning. Methods: Correlating observed dose as it relates to the geometric relationship of organs-at-risk (OARs) to planning target volumes (PTVs) yields mathematical models to predict achievable DVHs. In SRS, DVH-based QMs such as brain V 10Gy (volume receiving 10 Gy or more), gradient measure (GM), and conformity index (CI) are used to evaluate plan quality. This study encompasses 223 linear accelerator-based SRS/SRT treatment plans (SRS plans) using volumetric-modulated arc therapy (VMAT), representing 95% of the institution’s VMAT radiosurgery load from the past four and a half years. Unfiltered models that use all available plans for the model training were built for each category with a stratification scheme based on target and OAR characteristics determined emergently through initial modeling process. Model predictive accuracy is measured by the mean and standard deviation of the difference between clinical and predicted QMs, δQM = QM clin − QM pred , and a coefficient of determination, R 2 . For categories with a large number of plans, refined models are constructed by automatic elimination of suspected suboptimal plans from the training set. Using the refined model as a presumed achievable standard, potentially suboptimal plans are identified. Predictions of QM improvement are validated via standardized replanning of 20 suspected suboptimal plans based on dosimetric predictions. The significance of the QM improvement is evaluated using the Wilcoxon signed rank test. Results: The most accurate predictions are obtained when plans are stratified based on

O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction

Directory of Open Access Journals (Sweden)

Ibáñez Javier

2011-01-01

Full Text Available Abstract Background The DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction (MSP the most commonly used for promoter methylation study, while immunohistochemistry (IHC has become the most frequently used for the detection of MGMT protein expression. Agreement on the best and most reliable technique for evaluating MGMT status remains unsettled. The aim of this study was to perform a systematic review and meta-analysis of the correlation between IHC and MSP. Methods A computer-aided search of MEDLINE (1950-October 2009, EBSCO (1966-October 2009 and EMBASE (1974-October 2009 was performed for relevant publications. Studies meeting inclusion criteria were those comparing MGMT protein expression by IHC with MGMT promoter methylation by MSP in the same cohort of patients. Methodological quality was assessed by using the QUADAS and STARD instruments. Previously published guidelines were followed for meta-analysis performance. Results Of 254 studies identified as eligible for full-text review, 52 (20.5% met the inclusion criteria. The review showed that results of MGMT protein expression by IHC are not in close agreement with those obtained with MSP. Moreover, type of tumour (primary brain tumour vs others was an independent covariate of accuracy estimates in the meta-regression analysis beyond the cut-off value. Conclusions Protein expression assessed by IHC alone fails to reflect the promoter methylation status of MGMT. Thus, in attempts at clinical diagnosis the two methods seem to select different groups of patients and should not be used interchangeably.

Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation.