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Sample records for mgmt 3287-001 managerial

  1. Managerial Coaching

    Science.gov (United States)

    Bommelje, Rick

    2015-01-01

    This chapter explores how coaching equips managers and supervisors to be successful in the 21st-century workplace. Coaching has benefited these professionals by providing them with viable tools to enhance the leadership and managerial tools they already possess.

  2. Antineoplastic Effect of Decoy Oligonucleotide Derived from MGMT Enhancer

    Science.gov (United States)

    Refael, Miri; Zrihan, Daniel; Siegal, Tali; Lavon, Iris

    2014-01-01

    Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival. Therefore, it is conceivable to consider MGMT as a potential therapeutic target for the treatment of cancers. Our previous results demonstrated the pivotal role of NF-kappaB in MGMT expression, mediated mainly through p65/NF-kappaB homodimers. Here we show that the non-canonical NF-KappaB motif (MGMT-kappaB1) within MGMT enhancer is probably the major inducer of MGMT expression following NF-kappaB activation. Thus, in an attempt to attenuate the transcription activity of MGMT in tumors we designed locked nucleic acids (LNA) modified decoy oligonucleotides corresponding to the specific sequence of MGMT-kappaB1 (MGMT-kB1-LODN). Following confirmation of the ability of MGMT-kB1-LODN to interfere with the binding of p65/NF-kappaB to the NF-KappaB motif within MGMT enhancer, the efficacy of the decoy was studied in-vitro and in-vivo. The results of these experiments show that the decoy MGMT-kB1-LODN have a substantial antineoplastic effect when used either in combination with temozolomide or as monotherapy. Our results suggest that MGMT-kB1-LODN may provide a novel strategy for cancer therapy. PMID:25460932

  3. Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.

    Directory of Open Access Journals (Sweden)

    Tamar Canello

    Full Text Available Silencing of O(6-methylguanine-DNA-methyltransferase (MGMT in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival. Therefore, it is conceivable to consider MGMT as a potential therapeutic target for the treatment of cancers. Our previous results demonstrated the pivotal role of NF-kappaB in MGMT expression, mediated mainly through p65/NF-kappaB homodimers. Here we show that the non-canonical NF-KappaB motif (MGMT-kappaB1 within MGMT enhancer is probably the major inducer of MGMT expression following NF-kappaB activation. Thus, in an attempt to attenuate the transcription activity of MGMT in tumors we designed locked nucleic acids (LNA modified decoy oligonucleotides corresponding to the specific sequence of MGMT-kappaB1 (MGMT-kB1-LODN. Following confirmation of the ability of MGMT-kB1-LODN to interfere with the binding of p65/NF-kappaB to the NF-KappaB motif within MGMT enhancer, the efficacy of the decoy was studied in-vitro and in-vivo. The results of these experiments show that the decoy MGMT-kB1-LODN have a substantial antineoplastic effect when used either in combination with temozolomide or as monotherapy. Our results suggest that MGMT-kB1-LODN may provide a novel strategy for cancer therapy.

  4. Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.

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    Barbara Ingold

    Full Text Available The O(6-methylguanine-methyltransferase (MGMT promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. First clinical reports on treating brain metastases with temozolomide describe varying effects. This may be due to the fact that MGMT promoter methylation of brain metastases has not yet been explored in depth. Therefore, we assessed MGMT promoter methylation of various brain metastases including those derived from lung (n = 91, breast (n = 72 kidney (n = 49 and from malignant melanomas (n = 113 by methylation-specific polymerase chain reaction (MS-PCR and MGMT immunoreactivity. Fifty-nine of 199 brain metastases (29.6% revealed a methylated MGMT promoter. The methylation rate was the highest in brain metastases derived from lung carcinomas (46.5% followed by those from breast carcinoma (28.8%, malignant melanoma (24.7% and from renal carcinoma (20%. A significant correlation of homogeneous MGMT-immunoreactivity (>95% MGMT positive tumor cells and an unmethylated MGMT promoter was found. Promoter methylation was detected in 26 of 61 (43% tumors lacking MGMT immunoreactivity, in 17 of 63 (27% metastases with heterogeneous MGMT expression, but only in 5 of 54 brain metastases (9% showing a homogeneous MGMT immunoreactivity. Our results demonstrate that a significant number of brain metastases reveal a methylated MGMT-promoter. Based on an obvious correlation between homogeneous MGMT immunoreactivity and unmethylated MGMT promoter, we hypothesize that immunohistochemistry for MGMT may be a helpful diagnostic tool to identify those tumors that probably will not benefit from the use of alkylating agents. The discrepancy between promoter methylation and a lack of MGMT immunoreactivity argues for assessing MGMT promoter methylation both by immunohistochemical as well as by molecular approaches for diagnostic purposes.

  5. EG-15THE METHYLATION STATUS OF MGMT IN MEDULLOBLASTOMA

    Science.gov (United States)

    Shimizu, Yuzaburo; Kurimoto, Tomoko; Kondo, Akihide; Arai, Hajime

    2014-01-01

    BACKGROUND: Medulloblastoma is a highly malignant brain tumor in childhood. Some studies reported that alkylating chemotherapeutic drugs are effective agents in the treatment of patients with medulloblastoma. O6-methylguanine-DNA methyltransferase (MGMT) is one of the DNA repair enzymes and plays a significant role in tumor resistance to alkylating agents. Low MGMT expression or MGMT promoter methylation have been found to be associated with favorable outcomes in malignant glioma patients treated with alkylating agents such as temozolomide. However, impact of MGMT status on clinical outcomes in medulloblastoma patients is not fully evaluated. OBJECTIVE: The objective of this study is to investigate the association between MGMT status and the response for chemotherapy in pediatric patients with medulloblastoma. METHODS: Patients with medulloblastoma treated at our institution between 1995 and 2012 were reviewed retrospectively. Relevant clinical information including current disease status, tumor response to chemotherapy was obtained from the hospital charts. To evaluate the MGMT status, we performed bisulfite sequencing analysis to determine the methylation status of the MGMT promoter. RESULTS: Tumor material and detailed clinical information were available in 22 patients. Of them, 13 patients were alive (11 in CR), seven died of disease and two were lost to follow up. Five patients were with dissemination at diagnosis. We succeeded to evaluate both the MGMT status of tumors and the number of methylation sites in MGMT promoter. CONCLUSIONS: We studied the prognostic value of MGMT promoter methylation in medulloblastoma children.

  6. Managerial Imagination

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    Michael Savvas

    2016-02-01

    Full Text Available This article analyzes the links between imagination and human resource management. The concept imagination has received little scholarly attention within the field of management, despite its potential to inform a number of lines of inquiry. At the present time, much of the research literature on imagination is confined to the visual arts, literature, and education. Human resource (HR professionals could play a part in aligning employees with organizational goals and bring about organizational change if they developed their thinking in a more imaginative way. Developing managerial imagination can help solve the dilemmas and contradictions they face. A diagram is developed, which maps the development of the personnel function and offers four possibilities within a framework. They are biography, personal framing, history, and social structure. The outcome of this analysis provides a development of the personnel function one of which is a globally imaginative HR management. Within such a framework, the concept of “the imaginative performer” is discussed. The implications of combining imagination with management may provide a theoretical and practical way to understanding HR management.

  7. MGMT expression: insights into its regulation. 1. Epigenetic factors

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    Iatsyshyna A. P.

    2013-03-01

    Full Text Available O6-methylguanine-DNA methyltransferase (MGMT is the DNA repair enzyme responsible for removing of alkylation adducts from the O6-guanine in DNA. Despite MGMT prevents mutations and cell death, this enzyme can provide resistance of cancer cells to alkylating agents of chemotherapy. The high intra- and inter-individual variations in the human MGMT expression level have been observed indicating to a complicated regulation of this gene. This review is focused on the study of epigenetic factors which could be potentially involved in regulation of the human MGMT gene expression. These include chromatin remodeling via histone modifications and DNA methylation of promoter region and gene body, as well as RNA-based mechanisms, alternative splicing, protein post- translational modifications, and other.

  8. EG-11DYSREGULATION OF MGMT IN GLIOBLASTOMA: FRIEND OR FOE?

    Science.gov (United States)

    Rapkins, Robert W.; Hitchins, Megan P.; McDonald, Kerrie L.

    2014-01-01

    Glioblastoma (GBM) is the most common and lethal form of brain cancer (median survival <15 months). The DNA alkylating agent, temozolomide, is used as the standard chemotherapeutic agent, resulting in mispairing of guanine with thymidine that leads to cellular arrest. However, in GBM patients the O6-methylguanine-DNA methyltransferase (MGMT) protein protects DNA from damage induced by temozolomide. Nevertheless, loss of MGMT expression is a frequent event in human malignancies and typically the result of MGMT promoter methylation. MGMT methylation has been strongly associated with the T-allele of the rs16906252 SNP (C/T) in colorectal carcinoma, pleural mesothelioma, and lung cancers. We therefore examined the T-allele and MGMT methylation in temozolmide-treated GBM patients. In 255 temozolomide-treated GBM patients, we found that the T-allele was significantly more frequent in patients with a methylated MGMT promoter. The unadjusted hazard ratio for death in carriers of the T-allele compared to wild-type, irrespective of methylation status, was 0.39 (95%CI:0.21-0.73; p = 0.003), indicating a 61% relative reduction in the risk for death of T-allele carriers. Surprisingly, GBM patients harboring the T-allele in the absence of MGMT methylation showed a survival benefit comparable to those with MGMT methylation (median survival: 15.5 months) and significantly better than the median survival of wild-type, unmethylated patients (median survival: 10.3 months). This suggests that the T-allele may reduce MGMT activity by mechanisms independent of methylation. Genotyping of 451 healthy controls indicated the frequency of carriage of the T-allele was 13% (MAF 0.065). In contrast, carriage of the T-allele in 160 GBM patients was 17%. Significantly, elevated risks were associated with carriage of the T-allele and development of GBM (odds ratio of 2.62 [95%CI:1.7-4.2]). We report that the T-allele (rs16906252) has predictive (response to temozolomide) and prognostic value (MGMT

  9. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.

    NARCIS (Netherlands)

    B.J. Glassner (Brian); G. Weeda (Geert); J.M. Allan (James); J.L.M. Broekhof (Jose'); N.H.E. Carls (Nick); I. Donker (Ingrid); B.P. Engelward (Bevin); R.J. Hampson (Richard); R. Hersmus (Remko); M.J. Hickman (Mark); R.B. Roth (Richard); H.B. Warren (Henry); M.M. Wu (Mavis); J.H.J. Hoeijmakers (Jan); L.D. Samson (Leona)

    1999-01-01

    textabstractWe have generated mice deficient in O6-methylguanine DNA methyltransferase activity encoded by the murine Mgmt gene using homologous recombination to delete the region encoding the Mgmt active site cysteine. Tissues from Mgmt null mice displayed very low O6-methylguanine DNA

  10. The relationship between managerial skills and managerial effectiveness in a Managerial simulation game

    OpenAIRE

    Smutný Petr; Procházka Jakub; Vaculík Martin

    2016-01-01

    The study explores the relationship between managerial skills and managerial effectiveness, measuring managerial effectiveness by four different methods. Evaluation of 96 top managers of fictitious companies by a group of 1,746 subordinates took place after three months of intensive cooperation during a managerial simulation game. All respondents were college students. Results show that different managerial effectiveness indicators have different sets of managerial skills predictors: Group pe...

  11. MGMT DNA repair gene promoter/enhancer haplotypes alter transcription factor binding and gene expression.

    Science.gov (United States)

    Xu, Meixiang; Cross, Courtney E; Speidel, Jordan T; Abdel-Rahman, Sherif Z

    2016-10-01

    The O 6 -methylguanine-DNA methyltransferase (MGMT) protein removes O 6 -alkyl-guanine adducts from DNA. MGMT expression can thus alter the sensitivity of cells and tissues to environmental and chemotherapeutic alkylating agents. Previously, we defined the haplotype structure encompassing single nucleotide polymorphisms (SNPs) in the MGMT promoter/enhancer (P/E) region and found that haplotypes, rather than individual SNPs, alter MGMT promoter activity. The exact mechanism(s) by which these haplotypes exert their effect on MGMT promoter activity is currently unknown, but we noted that many of the SNPs comprising the MGMT P/E haplotypes are located within or in close proximity to putative transcription factor binding sites. Thus, these haplotypes could potentially affect transcription factor binding and, subsequently, alter MGMT promoter activity. In this study, we test the hypothesis that MGMT P/E haplotypes affect MGMT promoter activity by altering transcription factor (TF) binding to the P/E region. We used a promoter binding TF profiling array and a reporter assay to evaluate the effect of different P/E haplotypes on TF binding and MGMT expression, respectively. Our data revealed a significant difference in TF binding profiles between the different haplotypes evaluated. We identified TFs that consistently showed significant haplotype-dependent binding alterations (p ≤ 0.01) and revealed their role in regulating MGMT expression using siRNAs and a dual-luciferase reporter assay system. The data generated support our hypothesis that promoter haplotypes alter the binding of TFs to the MGMT P/E and, subsequently, affect their regulatory function on MGMT promoter activity and expression level.

  12. Residual Deep Convolutional Neural Network Predicts MGMT Methylation Status.

    Science.gov (United States)

    Korfiatis, Panagiotis; Kline, Timothy L; Lachance, Daniel H; Parney, Ian F; Buckner, Jan C; Erickson, Bradley J

    2017-10-01

    Predicting methylation of the O6-methylguanine methyltransferase (MGMT) gene status utilizing MRI imaging is of high importance since it is a predictor of response and prognosis in brain tumors. In this study, we compare three different residual deep neural network (ResNet) architectures to evaluate their ability in predicting MGMT methylation status without the need for a distinct tumor segmentation step. We found that the ResNet50 (50 layers) architecture was the best performing model, achieving an accuracy of 94.90% (+/- 3.92%) for the test set (classification of a slice as no tumor, methylated MGMT, or non-methylated). ResNet34 (34 layers) achieved 80.72% (+/- 13.61%) while ResNet18 (18 layers) accuracy was 76.75% (+/- 20.67%). ResNet50 performance was statistically significantly better than both ResNet18 and ResNet34 architectures (p deep neural architectures can be used to predict molecular biomarkers from routine medical images.

  13. Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation

    International Nuclear Information System (INIS)

    Taioli, Emanuela; Ragin, Camille; Wang, Xiao-hong; Chen, Jiangying; Langevin, Scott M; Brown, Ashley R; Gollin, Susanne M; Garte, Seymour; Sobol, Robert W

    2009-01-01

    Biomarkers that predict clinical response, tumor recurrence or patient survival are severely lacking for most cancers, particularly for oral and pharyngeal cancer. This study examines whether gene-promoter methylation of tumor DNA correlates with survival and recurrence rates in a population of patients with oral or pharyngeal cancer. The promoter methylation status of the DNA repair gene MGMT and the tumor suppressor genes CDKN2A and RASSF1 were evaluated by methylation-specific PCR in 88 primary oral and pharyngeal tumors and correlated with survival and tumor recurrence. Quantitative MGMT methylation was also assessed. 29.6% of the tumors presented with MGMT methylation, 11.5% with CDKN2A methylation and 12.1% with RASSF1 methylation. MGMT promoter methylation was significantly associated with poorer overall and disease-free survival. No differences in methylation status of MGMT and RASSF1 with HPV infection, smoking or drinking habits were observed. A significant inverse trend with the amount of MGMT methylation and overall and disease-free survival was observed (p trend = 0.002 and 0.001 respectively). These results implicate MGMT promoter methylation as a possible biomarker for oral and pharyngeal cancer prognosis. The critical role of MGMT in DNA repair suggests that defective DNA repair may be correlative in the observed association between MGMT promoter methylation and tumor recurrence. Follow-up studies should include further quantitative MSP-PCR measurement, global methylation profiling and detailed analysis of downstream DNA repair genes regulated by promoter methylation

  14. Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma.

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    Tao Fu

    Full Text Available O6-methylguanine-DNA methyltransferase (MGMT methylation status has not been extensively investigated in duodenal adenocarcinoma (DA. The aim of this study was to evaluate the MGMT methylation status and examine its possible prognostic value in patients with stage III DA.Demographics, tumor characteristics and survival were available for 64 patients with stage III DA. MGMT methylation was detected by using MethyLight. A Cox proportional hazard model was built to predict survival, adjusted for clinicopathological characteristics and tumor molecular features, including the CpG island methylator phenotype (CIMP, microsatellite instability (MSI, and KRAS mutations.MGMT methylation was detected in 17 of 64 (26.6% patients, and was not correlated with sex, age, tumor differentiation, CIMP, MSI, or KRAS mutations. MGMT methylation was the only one factor associated with both overall survival (OS and disease-free survival (DFS on both univariate and multivariate analyses. In patients treated with surgery alone, MGMT-methylated group had worse OS and DFS when compared with MGMT-unmethylated group. However, in patients treated with chemotherapy/radiotherapy, outcomes became comparable between the two groups.Our results demonstrate MGMT methylation is a reliable and independent prognostic factor in DAs. Methylation of MGMT is associated with poor prognosis in patients with stage III DAs.

  15. Volumetric and MGMT parameters in glioblastoma patients: Survival analysis

    International Nuclear Information System (INIS)

    Iliadis, Georgios; Kotoula, Vassiliki; Chatzisotiriou, Athanasios; Televantou, Despina; Eleftheraki, Anastasia G; Lambaki, Sofia; Misailidou, Despina; Selviaridis, Panagiotis; Fountzilas, George

    2012-01-01

    In this study several tumor-related volumes were assessed by means of a computer-based application and a survival analysis was conducted to evaluate the prognostic significance of pre- and postoperative volumetric data in patients harboring glioblastomas. In addition, MGMT (O 6 -methylguanine methyltransferase) related parameters were compared with those of volumetry in order to observe possible relevance of this molecule in tumor development. We prospectively analyzed 65 patients suffering from glioblastoma (GBM) who underwent radiotherapy with concomitant adjuvant temozolomide. For the purpose of volumetry T1 and T2-weighted magnetic resonance (MR) sequences were used, acquired both pre- and postoperatively (pre-radiochemotherapy). The volumes measured on preoperative MR images were necrosis, enhancing tumor and edema (including the tumor) and on postoperative ones, net-enhancing tumor. Age, sex, performance status (PS) and type of operation were also included in the multivariate analysis. MGMT was assessed for promoter methylation with Multiplex Ligation-dependent Probe Amplification (MLPA), for RNA expression with real time PCR, and for protein expression with immunohistochemistry in a total of 44 cases with available histologic material. In the multivariate analysis a negative impact was shown for pre-radiochemotherapy net-enhancing tumor on the overall survival (OS) (p = 0.023) and for preoperative necrosis on progression-free survival (PFS) (p = 0.030). Furthermore, the multivariate analysis confirmed the importance of PS in PFS and OS of patients. MGMT promoter methylation was observed in 13/23 (43.5%) evaluable tumors; complete methylation was observed in 3/13 methylated tumors only. High rate of MGMT protein positivity (> 20% positive neoplastic nuclei) was inversely associated with pre-operative tumor necrosis (p = 0.021). Our findings implicate that volumetric parameters may have a significant role in the prognosis of GBM patients. Furthermore

  16. Standing up to Managerialism

    Science.gov (United States)

    Rowe, Stephen

    2014-01-01

    "Managerialism" represents a relatively new orientation to college and university administration, one that arises from the coincidence of three distinct features of the contemporary landscape: market rationality, nihilism, and the modern wish for a new beginning. In this article, the author offers simple clarification as to the nature of…

  17. Decentralisation, managerialism and accountability:

    DEFF Research Database (Denmark)

    Robinson, Sarah

    2015-01-01

    on the people inside an Australian state education administration during the time when the organisation was being restructured. It examines how decentralisation, managerialism and accountability result in the loss of professional expertise. This study contributes to the literature on the neo...

  18. Managerial Accounting. Study Guide.

    Science.gov (United States)

    Plachta, Leonard E.

    This self-instructional study guide is part of the materials for a college-level programmed course in managerial accounting. The study guide is intended for use by students in conjuction with a separate textbook, Horngren's "Accounting for Management Control: An Introduction," and a workbook, Curry's "Student Guide to Accounting for Management…

  19. Strategic planning and managerial control

    OpenAIRE

    Mihaela Ghicajanu

    2004-01-01

    In this paper present relationship among strategic planning and managerial control process. For begin I want present few elements about strategic planning and managerial control in order to identify link inter these elements.

  20. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Lower MGMT expression predicts better prognosis in proneural-like glioblastoma

    Science.gov (United States)

    He, Zhi-Cheng; Ping, Yi-Fang; Xu, Sen-Lin; Lin, Yong; Yu, Shi-Cang; Kung, Hsiang-Fu; Bian, Xiu-Wu

    2015-01-01

    Objective: To investigate the expression and significance of MGMT in different molecular subtypes of glioblastoma (GBM), and to evaluate the important role of MGMT and P53 in predicting the prognosis of GBM patients. Methods: MGMT expression was detected by immunohistochemical staining in 72 cases of GBM which had been classified as three molecular subtypes. The relationship between MGMT and P53, an important molecule for identification of proneural-like GBM, were further analyzed. The association between MGMT and patients’ prognosis was analyzed with Kaplan-Meier method, which was further validated by the data from 513 cases of GBM in the TCGA database. Results: MGMT expression was lower in proneural-like subtype in 72 GBM cases (p < 0.001), and was negatively correlated with P53 (r=-0. 6203, p < 0.001). This results was also verified by a validation group of 87 GBM cases (r=-0. 2950, p < 0.001). Interestingly, low expression of MGMT predicted a better outcome in proneurallike subtype or P53 high-expression group (p < 0.05) but not in non-proneural-like subtype and P53 low-expression group. All of these results were verified by the data from TCGA database. Conclusion: MGMT can be used as an independent prognostic factor and plays an important role in molecular typing and diagnosis of GBM by combination with proneural-like subtype marker P53. PMID:26884942

  2. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

    Science.gov (United States)

    Kaina, Bernd; Christmann, Markus; Naumann, Steffen; Roos, Wynand P

    2007-08-01

    O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O(6)-alkylguanine in DNA (collectively termed O(6)-alkylating agents [O(6)AA]). The defense is highly important, since O(6)AA are common environmental carcinogens, are formed endogenously during normal cellular metabolism and possibly inflammation, and are being used in cancer therapy. O(6)AA induced DNA damage is subject to repair, which is executed by MGMT, AlkB homologous proteins (ABH) and base excision repair (BER). Although this review focuses on MGMT, the mechanism of repair by ABH and BER will also be discussed. Experimental systems, in which MGMT has been modulated, revealed that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine are major mutagenic, carcinogenic, recombinogenic, clastogenic and killing lesions. O(6)MeG-induced clastogenicity and cell death require MutS alpha-dependent mismatch repair (MMR), whereas O(6)-chloroethylguanine-induced killing occurs independently of MMR. Extensive DNA replication is required for O(6)MeG to provoke cytotoxicity. In MGMT depleted cells, O(6)MeG induces apoptosis almost exclusively, barely any necrosis, which is presumably due to the remarkable ability of secondarily formed DNA double-strand breaks (DSBs) to trigger apoptosis via ATM/ATR, Chk1, Chk2, p53 and p73. Depending on the cellular background, O(6)MeG activates both the death receptor and the mitochondrial apoptotic pathway. The inter-individual expression of MGMT in human lymphocytes is highly variable. Given the key role of MGMT in cellular defense, determination of MGMT activity could be useful for assessing a patient's drug sensitivity. MGMT is expressed at highly variable amounts in human tumors. In gliomas, a correlation was found between MGMT activity, MGMT promoter methylation and response to O(6)AA. Although the human MGMT gene is inducible by glucocorticoids and genotoxins such as radiation and

  3. Cultural Impacts in Managerial Accounting

    OpenAIRE

    Flavius Guinea

    2006-01-01

    From the theoretical point of view, it has been stated that there is a considerable probability that some cultural aspects could affect the economic environment and, consequently, the managerial accounting. While this statement has a certain suppositional degree, we will try to test the importance of culture within the managerial accounting. Several empirical approaches underline the existence of a powerful impact of the national culture on the managerial accounting systems. Moreover, it is c...

  4. Topical Interface between Managerial Finance and Managerial Accounting.

    Science.gov (United States)

    Williams, Norman C.; Swanson, G. A.

    1988-01-01

    The authors present a method to examine the interfaces between business courses for redundancy. The method is demonstrated by examining the content in managerial finance and managerial accounting courses. A decision model application of analysis, expert judgment, and synthesis are incorporated in this method. (CH)

  5. ET-09DECOY OLIGONUCLEOTIDE DERIVED FROM MGMT ENHANCER HAS AN ANTINEOPLASTIC ACTIVITY IN-VITRO AND IN-VIVO

    Science.gov (United States)

    Canello, Tamar; Ovadia, Haim; Refael, Miri; Zrihan, Daniel; Siegal, Tali; Lavon, Iris

    2014-01-01

    INTRODUCTION: Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, correlates with a better therapeutic response and with increased survival. Our previous results demonstrated the pivotal role of NF-kappaB in MGMT expression, mediated mainly through binding of p65/NF-kappaB homodimers to the non-canonical NF-KappaB motif (MGMT-kappaB1) within MGMT enhancer. METHODS AND RESULTS: In an attempt to attenuate the transcription activity of MGMT in tumors we designed locked nucleic acids (LNA) modified decoy oligonucleotides corresponding to the specific sequence of MGMT-kappaB1 (MGMT-kB1-LODN). Following confirmation of the ability of MGMT-kB1-LODN to interfere with the binding of p65/NF-kappaB to MGMT enhancer, the potential of the MGMT-kB1-LODN to enhance cell killing was studied in vitro in two glioma cell lines (T98G and U87) and a melanoma cell line (A375P). All three cell lines manifested a significant enhanced cell killing effect following exposure to temozolomide (TMZ) when first transfected with MGMT-kb1-LODN, and also induced a significant cell killing when administered as monotherapy. These results were confirmed also in-vivo on A375P Melanoma xenografts. Intratumoral (Intralesional - IL) injection of MGMT-kB1-LODN with or without IP injection of TMZ induced significant tumor growth inhibition either as a monotherapy or in combination with TMZ. The long-term effect of MGMT-kB1-LODN monotherapy was evaluated using a repetitive IL injection every 4 to 5 days for 55 days with either MGMT-κB1 LODN or control ODN or vehicle. A significant difference (p < 0.01) in tumor volume was obtained by MGMT-κB1-LODN compared to both control groups. Moreover, two out of the seven mice treated with MGMT-κB1-LODN demonstrated tumor regression by day 55 and no tumor recurrence was observed five months later. CONCLUSION: The results of these experiments show that the MGMT-kB1-LODN has a substantial antineoplastic effect when used either in combination with

  6. Managerial coaching: a concept analysis.

    Science.gov (United States)

    Batson, Vicki D; Yoder, Linda H

    2012-07-01

    This article presents a report of a concept analysis of managerial coaching. Managerial coaching has been identified as a means for managers to give support to staff nurses, however, no clear delineation of what behaviours and attributes constitute managerial coaching or differentiate it from other career development relationships is provided in the current nursing literature. The CINAHL, ProQuest, Business Source Complete and PscyhIFNO databases were searched for articles published between 1980-2009 using the keywords coaching, managerial coaching, nurse manager support, nursing leadership, self-efficacy, work environment and empowerment. A hybrid approach was used, incorporating both Walker and Avant's method of concept analysis and King's conceptual system and Theory of Goal Attainment to explore the meaning of managerial coaching. Inclusive years of search ranged from 1980-2009. Managerial coaching is a specific dyadic relationship between the nurse manager and staff nurse intended to improve skills and knowledge as they relate to expected job performance. Antecedents and consequences are categorized at the individual and organizational level. Defining attributes, empirical referents and a model case are presented. The theoretical definition for this concept helps to differentiate it from other types of career development relationships and will give a basis for nurse managers to understand what skills and attributes are necessary to establish an effective managerial coaching relationship with staff nurses. Conceptualization will also assist in developing empirical studies examining managerial coaching behaviours in the work environment. © 2012 Blackwell Publishing Ltd.

  7. Managerial technology transfer

    CERN Document Server

    2012-01-01

    Organisations need to think globally, but act locally - with a full appreciation of the diversity of local cultures. Major global companies must recognise that policies need to be managed with the broad context of business strategy and integrated into the work culture with the support of all elements of human resources management. Most currently, companies are accommodating national cultural differences while preserving work culture principals that encourage people to effectively execute the company's strategic objectives. Even to the casual observer, it is apparent that culture- a society's programming of the mind- has both a pervasive and changing influence on each national business environment. Global managers must recognise the influence of culture and be prepared to either respond to it or change it. This book examines current research in the study of managerial technology transfer.

  8. Expression and relevant research of MGMT and XRCC1 gene in differentgrades of brain glioma and normal brain tissues

    Institute of Scientific and Technical Information of China (English)

    Ya-Fei Zhang

    2015-01-01

    Objective: To explore and analyze expression and relevant research of MGMT and XRCC1 gene in different grades of brain glioma and normal brain tissues. Methods: 52 cases of patients with brain glioma treated in our hospital from December 2013 to December 2014, and 50 cases of normal brain-tissue patients with intracranial hypertension were selected, and proceeding test to the surgical resection of brain tissue of the above patients to determine its MGMT and XRCC1 protein content, sequentially to record the expression of MGMT and XRCC1 of both groups. Grading of tumors to brain glioma after operation was carried out, and the expression of MGMT and XRCC1 gene in brain tissues of different patients was analyzed and compared;finally the contingency tables of X2 test was used to analyze the correlation of XRCC1and MGMT. Results:Positive rate of MGMT expression in normal brain tissue was 2%,while positive rate of MGMT expression in brain glioma was 46.2%,which was obviously higher than that in normal brain tissues (χ2=26.85, P0.05), which had no statistical significance. There were 12 cases of patients whose MGMT protein expression was positive and XRCC1 protein expression was positive; there were 18 cases of patients whose MGMT protein expression was negative and XRCC1 protein expression was negative. Contingency tables of X2 test was used to analyze the correlation of XRCC1 and MGMT, which indicated that the expression of XRCCI and MGMT in brain glioma had no correlation (r=0.9%, P=0.353), relevancy of both was r=0.9%. Conclusions: Positive rate of the expression of MGMT and XRCC1 in brain glioma was obviously higher than that in normal brain tissues, but the distribution of different grades of brain glioma had no obvious difference, and MGMT and XRCC1 expression had no obvious correlation, which needed further research.

  9. Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

    OpenAIRE

    Jue, Toni Rose; Nozue, Kyoko; Lester, Ashleigh J.; Joshi, Swapna; Schroder, Lisette B. W.; Whittaker, Shane P.; Nixdorf, Sheri; Rapkins, Robert W.; Khasraw, Mustafa; McDonald, Kerrie L.

    2017-01-01

    Background The O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive to the standard treatment regime of surgery followed by concurrent radiotherapy (RT) and temozolomide. Here, we investigate the efficacy of adding a PARP inhibitor, veliparib, to radiotherapy to treat MGMT unmethylated GBM. Methods The inhibition of PARP with veliparib (ABT-888), a potent and orally bioavailable inhibitor in combination ...

  10. The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma

    Directory of Open Access Journals (Sweden)

    Veronica Villani

    2015-01-01

    Full Text Available O6-methylguanine-DNA-methyltransferase (MGMT has emerged as a relevant predictor of therapeutic response and good prognosis in patients with glioblastoma (GBM. Transcriptionally active MGMT rapidly removes the alkyl adducts, preventing the formation of cross-links and thereby causing resistance to alkylating drugs. Studies with pyrosequencing (PSQ showed that this technique has a higher reproducibility and sensitivity than other techniques. However, the definition of a prognostically relevant threshold for the percentage of MGMT methylation remains one of the most critical issues in the use of PSQ analysis. The aim of this study was to define the cut-off value correlated with good favourable prognostic outcomes. We retrospectively analyzed 51 patients (33 males, 18 females with GBM who underwent surgery or biopsy. The Receiver Operating Characteristics analysis showed that the best possible criteria for PSQ-detected percentage of MGMT methylation that predicted progression-free survival (PFS and overall survival (OS were 19% and 13%, respectively. Patients with ≤19% of PSQ-detected MGMT had a shorter PFS (HR: 0.24, p<0.01; those ones with ≤13% had a shorter OS (HR: 0.33, p<0.05. Our study reinforces the importance of MGMT in the management of GBM patients, but future studies with larger sample sizes are warranted to confirm our findings.

  11. Cultural Impacts in Managerial Accounting

    Directory of Open Access Journals (Sweden)

    Flavius Guinea

    2006-08-01

    Full Text Available From the theoretical point of view, it has been stated that there is a considerable probability that some cultural aspects could affect the economic environment and, consequently, the managerial accounting. While this statement has a certain suppositional degree, we will try to test the importance of culture within the managerial accounting. Several empirical approaches underline the existence of a powerful impact of the national culture on the managerial accounting systems. Moreover, it is clear for everybody that the companies’ strategic objectives are often expressed in numerical terms, but they are chosen according to the culture.

  12. Research on DNA methylation of human osteosarcoma cell MGMT and its relationship with cell resistance to alkylating agents.

    Science.gov (United States)

    Guo, Jun; Cui, Qiu; Jiang, WeiHao; Liu, Cheng; Li, DingFeng; Zeng, Yanjun

    2013-08-01

    The objective of this study was to explore the O(6)-methylguanine-DNA methyltransferase (MGMT) gene methylation status and its protein expression, as well as the effects of demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-CdR) on MGMT gene expression and its resistance to alkylating agents, and to elucidate MGMT expression mechanism and significance in osteosarcoma. The human osteosarcoma cell lines Saos-2 and MG-63 were collected and treated with 5-Aza-CdR for 6 days. The cells not treated with 5-Aza-CdR were set as a negative control. The genomic DNA was extracted from the Saos-2 and MG-63 cells using methylation-specific PCR to detect the promoter CpG island methylation status of the MGMT gene. Cell sensitivity to alkylating agents before and after drug administration was detected by the MTT method. The variation in MGMT gene mRNA and protein was detected by reverse transcription PCR (RT-PCR) and Western blotting. The MGMT promoter gene of normal Saos-2 cells was methylated, with reduced MGMT mRNA and protein expression; the MGMT mRNA and protein expression of Saos-2 cells treated with 5-Aza-CdR was obviously enhanced, and its sensitivity to alkylating agents was reversed. Meanwhile, with promoter CpG island unmethylation of the MGMT gene, MGMT protein was expressed in the normal MG-63 cells and the MG-63 cells treated with 5-Aza-CdR, and both showed resistance to alkylating agents. The methylation status of the MGMT gene promoter in human osteosarcoma cells reflected the cells' ability to induce MGMT protein expression and can be used as a molecular marker to project the sensitivity of cancer tissues to alkylating agent drugs.

  13. Different diagnostic values of imaging parameters to predict pseudoprogression in glioblastoma subgroups stratified by MGMT promoter methylation

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ra Gyoung [Catholic Kwandong University International St. Mary' s Hospital, Department of Radiology, Catholic Kwandong University College of Medicine, Incheon (Korea, Republic of); Kim, Ho Sung; Shim, Woo Hyun; Kim, Sang Joon [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Paik, Wooyul [Dankook Unversity Hospital, Department of Radiology, Cheonan-si, Chungcheongnam-do (Korea, Republic of); Kim, Jeong Hoon [University of Ulsan College of Medicine, Asan Medical Center, Department of Neurosurgery, Seoul (Korea, Republic of)

    2017-01-15

    The aim of this study was to determine whether diffusion and perfusion imaging parameters demonstrate different diagnostic values for predicting pseudoprogression between glioblastoma subgroups stratified by O{sup 6}-mythylguanine-DNA methyltransferase (MGMT) promoter methylation status. We enrolled seventy-five glioblastoma patients that had presented with enlarged contrast-enhanced lesions on magnetic resonance imaging (MRI) one month after completing concurrent chemoradiotherapy and undergoing MGMT promoter methylation testing. The imaging parameters included 10 or 90 % histogram cutoffs of apparent diffusion coefficient (ADC10), normalized cerebral blood volume (nCBV90), and initial area under the time signal-intensity curve (IAUC90). The results of the areas under the receiver operating characteristic curve (AUCs) with cross-validation were compared between MGMT methylation and unmethylation groups. MR imaging parameters demonstrated a trend toward higher accuracy in the MGMT promoter methylation group than in the unmethylation group (cross-validated AUCs = 0.70-0.95 and 0.56-0.87, respectively). The combination of MGMT methylation status with imaging parameters improved the AUCs from 0.70 to 0.75-0.90 for both readers in comparison with MGMT methylation status alone. The probability of pseudoprogression was highest (95.7 %) when nCBV90 was below 4.02 in the MGMT promoter methylation group. MR imaging parameters could be stronger predictors of pseudoprogression in glioblastoma patients with the methylated MGMT promoter than in patients with the unmethylated MGMT promoter. (orig.)

  14. Managerial Attention in International SMEs

    NARCIS (Netherlands)

    Fan, Jiasi

    2017-01-01

    Managerial attention affects organizational strategies and the resulting consequences. In the international business context, it is noted that how much attention managers give to the international marketplace, i.e., international attention, has profound implications for large global companies’

  15. Accounting information and managerial work

    OpenAIRE

    Matthew Hall

    2010-01-01

    Despite calls to link management accounting more closely to management (Jonsson, 1998), much is still to be learned about the role of accounting information in managerial work. This lack of progress stems partly from a failure to incorporate in research efforts the findings regarding the nature of managerial work, as well as inadequate attention devoted to the detailed practices through which accounting information is actually used by managers in their work. In this paper I draw on prior rese...

  16. THE EVOLUTION OF MANAGERIAL ACCOUNTING

    OpenAIRE

    Delia MANEA

    2012-01-01

    The technological and organizational changes that have occurred in recent years, led to the apparition and then to continuous changes in managerial accounting, requiring the reconsideration of the existing informational system, so that it will contain all the information that managers need in order to make economic decisions. This paper aims to present the most important events that have marked the evolution of managerial accounting from its occurrence until today, and some courses of action ...

  17. MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma

    Directory of Open Access Journals (Sweden)

    Skiriute Daina

    2012-06-01

    Full Text Available Abstract Background Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epigenetic markers and evaluate its separate and concomitant role in glioblastoma genesis and patient outcome. Methods The methylation status of MGMT, CD81, GATA6, DR4, and CASP8 in 76 patients with primary glioblastomas was investigated. Methylation-specific PCR reaction was performed using bisulfite treated DNA. Evaluating glioblastoma patient survival time after operation, patient data and gene methylation effect on survival was estimated using survival analysis. Results The overwhelming majority (97.3% of tumors were methylated in at least one of five genes tested. In glioblastoma specimens gene methylation was observed as follows: MGMT in 51.3%, GATA6 in 68.4%, CD81 in 46.1%, DR4 in 41.3% and CASP8 in 56.8% of tumors. Methylation of MGMT was associated with younger patient age (p CASP8 with older (p MGMT methylation was significantly more frequent event in patient group who survived longer than 36 months after operation (p CASP8 was more frequent in patients who survived shorter than 36 months (p MGMT, GATA6 and CASP8 as independent predictors for glioblastoma patient outcome (p MGMT and GATA6 were independent predictors for patient survival in younger patients’ group, while there were no significant associations observed in older patients’ group when adjusted for therapy. Conclusions High methylation frequency of tested genes shows heterogeneity of glioblastoma epigenome and the importance of MGMT, GATA6 and CASP8 genes methylation in glioblastoma patient outcome.

  18. Relationship between promoter methylation & tissue expression of MGMT gene in ovarian cancer

    Directory of Open Access Journals (Sweden)

    V Shilpa

    2014-01-01

    Full Text Available Background & objectives: Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumour suppressor genes. O 6 -methyguanine-DNA methyltransferase (MGMT is a DNA repair gene that removes mutagenic and cytotoxic adducts from the O 6 -position of guanine induced by alkylating agents. MGMT promoter hypermethylation and reduced expression has been found in some primary human carcinomas. We studied DNA methylation of CpG islands of the MGMT gene and its relation with MGMT protein expression in human epithelial ovarian carcinoma. Methods: A total of 88 epithelial ovarian cancer (EOC tissue samples, 14 low malignant potential (LMP tumours and 20 benign ovarian tissue samples were analysed for MGMT promoter methylation by nested methylation-specific polymerase chain reaction (MSP after bisulphite modification of DNA. A subset of 64 EOC samples, 10 LMP and benign tumours and five normal ovarian tissue samples were analysed for protein expression by immunohistochemistry. Results: The methylation frequencies of the MGMT gene promoter were found to be 29.5, 28.6 and 20 per cent for EOC samples, LMP tumours and benign cases, respectively. Positive protein expression was observed in 93.8 per cent of EOC and 100 per cent in LMP, benign tumours and normal ovarian tissue samples. Promoter hypermethylation with loss of protein expression was seen only in one case of EOC. Interpretation & conclusions: Our results suggest that MGMT promoter hypermethylation does not always reflect gene expression.

  19. ROMANIAN MANAGERIAL APROACHES

    Directory of Open Access Journals (Sweden)

    Rusu Liviu Dumitru

    2015-07-01

    Full Text Available Globalization has deeply turned the macroeconomic environment as well as the behaviour of organizations on the global market. Increasingly fierce competition on this market has contributed to the emergence and crystallization of the euro management which was called upon to respond to this challenge. It is closely related to organizational culture and developed on the basis of the integration of markets and economies which led to the appearance, in the management area, of a methods ’ concentration, management techniques and methodologies specific to the European countries. As a part of the European management, the Romanian management involves the formulation of some specific traits, defining features, detached from its approach both on processes and management functions as well as on the components of the management system. This approach results from the organization's system feature called "management system". The objectives of this work consist in the formulation of some relevant answers to questions like: "Do the Romanian Managers have a certain conception in terms of functions of the management processes?"; "Was there outlined a specific content for each of the five managerial functions?"; "Is the content of the management components /subsystems already patterned?". As a methodology, from the answer to these questions , there will be taken some conclusions on the "Romanian management" from the theoretical-methodological point of view as a first stage and, on the second stage, as a pragmatic approach on the Romanian organizations and generally within the business environment in Romania. As a result, in the end we present the defining elements of the "Romanian management pattern", to the extent that we come to the conclusion that one can speak of such a model and which are the common and distinct traits as against the European management.

  20. Screening_mgmt: a Python module for managing screening data.

    Science.gov (United States)

    Helfenstein, Andreas; Tammela, Päivi

    2015-02-01

    High-throughput screening is an established technique in drug discovery and, as such, has also found its way into academia. High-throughput screening generates a considerable amount of data, which is why specific software is used for its analysis and management. The commercially available software packages are often beyond the financial limits of small-scale academic laboratories and, furthermore, lack the flexibility to fulfill certain user-specific requirements. We have developed a Python module, screening_mgmt, which is a lightweight tool for flexible data retrieval, analysis, and storage for different screening assays in one central database. The module reads custom-made analysis scripts and plotting instructions, and it offers a graphical user interface to import, modify, and display the data in a uniform manner. During the test phase, we used this module for the management of 10,000 data points of various origins. It has provided a practical, user-friendly tool for sharing and exchanging information between researchers. © 2014 Society for Laboratory Automation and Screening.

  1. DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

    Science.gov (United States)

    Fahrer, Jörg; Frisch, Janina; Nagel, Georg; Kraus, Alexander; Dörsam, Bastian; Thomas, Adam D; Reißig, Sonja; Waisman, Ari; Kaina, Bernd

    2015-10-01

    Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated base excision repair, respectively. In view of recent evidence of nonlinear mutagenicity for NOC-like compounds, the question arises as to the existence of threshold doses in CRC formation. Here, we set out to determine the impact of DNA repair on the dose-response of alkylation-induced CRC. DNA repair proficient (WT) and deficient (Mgmt (-/-), Aag (-/-) and Mgmt (-/-)/Aag (-/-)) mice were treated with azoxymethane (AOM) and dextran sodium sulfate to trigger CRC. Tumors were quantified by non-invasive mini-endoscopy. A non-linear increase in CRC formation was observed in WT and Aag (-/-) mice. In contrast, a linear dose-dependent increase in tumor frequency was found in Mgmt (-/-) and Mgmt (-/-)/Aag (-/-) mice. The data were corroborated by hockey stick modeling, yielding similar carcinogenic thresholds for WT and Aag (-/-) and no threshold for MGMT lacking mice. O (6)-MeG levels and depletion of MGMT correlated well with the observed dose-response in CRC formation. AOM induced dose-dependently DNA double-strand breaks in colon crypts including Lgr5-positive colon stem cells, which coincided with ATR-Chk1-p53 signaling. Intriguingly, Mgmt (-/-) mice displayed significantly enhanced levels of γ-H2AX, suggesting the usefulness of γ-H2AX as an early genotoxicity marker in the colorectum. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG, as a key node in determining a carcinogenic threshold. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. MRI texture features as biomarkers to predict MGMT methylation status in glioblastomas

    Energy Technology Data Exchange (ETDEWEB)

    Korfiatis, Panagiotis; Kline, Timothy L.; Erickson, Bradley J., E-mail: bje@mayo.edu [Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States); Coufalova, Lucie [Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States); Department of Neurosurgery of First Faculty of Medicine, Charles University in Prague, Military University Hospital, Prague 128 21 (Czech Republic); International Clinical Research Center, St. Anne’s University Hospital Brno, Brno 656 91 (Czech Republic); Lachance, Daniel H. [Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States); Parney, Ian F. [Department of Neurologic Surgery, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States); Carter, Rickey E. [Department of Health Sciences Research, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States); Buckner, Jan C. [Department of Medical Oncology, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905 (United States)

    2016-06-15

    Purpose: Imaging biomarker research focuses on discovering relationships between radiological features and histological findings. In glioblastoma patients, methylation of the O{sup 6}-methylguanine methyltransferase (MGMT) gene promoter is positively correlated with an increased effectiveness of current standard of care. In this paper, the authors investigate texture features as potential imaging biomarkers for capturing the MGMT methylation status of glioblastoma multiforme (GBM) tumors when combined with supervised classification schemes. Methods: A retrospective study of 155 GBM patients with known MGMT methylation status was conducted. Co-occurrence and run length texture features were calculated, and both support vector machines (SVMs) and random forest classifiers were used to predict MGMT methylation status. Results: The best classification system (an SVM-based classifier) had a maximum area under the receiver-operating characteristic (ROC) curve of 0.85 (95% CI: 0.78–0.91) using four texture features (correlation, energy, entropy, and local intensity) originating from the T2-weighted images, yielding at the optimal threshold of the ROC curve, a sensitivity of 0.803 and a specificity of 0.813. Conclusions: Results show that supervised machine learning of MRI texture features can predict MGMT methylation status in preoperative GBM tumors, thus providing a new noninvasive imaging biomarker.

  3. MRI texture features as biomarkers to predict MGMT methylation status in glioblastomas

    International Nuclear Information System (INIS)

    Korfiatis, Panagiotis; Kline, Timothy L.; Erickson, Bradley J.; Coufalova, Lucie; Lachance, Daniel H.; Parney, Ian F.; Carter, Rickey E.; Buckner, Jan C.

    2016-01-01

    Purpose: Imaging biomarker research focuses on discovering relationships between radiological features and histological findings. In glioblastoma patients, methylation of the O 6 -methylguanine methyltransferase (MGMT) gene promoter is positively correlated with an increased effectiveness of current standard of care. In this paper, the authors investigate texture features as potential imaging biomarkers for capturing the MGMT methylation status of glioblastoma multiforme (GBM) tumors when combined with supervised classification schemes. Methods: A retrospective study of 155 GBM patients with known MGMT methylation status was conducted. Co-occurrence and run length texture features were calculated, and both support vector machines (SVMs) and random forest classifiers were used to predict MGMT methylation status. Results: The best classification system (an SVM-based classifier) had a maximum area under the receiver-operating characteristic (ROC) curve of 0.85 (95% CI: 0.78–0.91) using four texture features (correlation, energy, entropy, and local intensity) originating from the T2-weighted images, yielding at the optimal threshold of the ROC curve, a sensitivity of 0.803 and a specificity of 0.813. Conclusions: Results show that supervised machine learning of MRI texture features can predict MGMT methylation status in preoperative GBM tumors, thus providing a new noninvasive imaging biomarker.

  4. Managerial level, managerial motivation and sense of coherence

    Directory of Open Access Journals (Sweden)

    MG Coetzee

    2006-04-01

    Full Text Available The first objective of the study was to assess whether the dimensions of Antonovsky’s Sense of Coherence (SOC scale correlated positively with those of the Managerial Motivation scale (MMQ. The second objective was to establish whether managers and supervisors differed with regard to sense of coherence and managerial motivation. The respondents were 124 employees of the Agricultural Research Council. None of the sense of coherence scales correlated with Attitude towards authority figures (MMQ. Also, Meaningfulness (SOC and Willingness to conduct administrative functions (MMQ did not correlate. However, the remainder of the correlations supported the hypothesis, indicating a strong positive relationship between managerial motivation and sense of coherence. Statistically significant differences between managers and supervisors were obtained for only two variables, namely Meaningfulness (SOC and Power motive (MMQ.

  5. Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma

    DEFF Research Database (Denmark)

    Kristensen, Lasse S; Michaelsen, Signe R; Dyrbye, Henrik

    2016-01-01

    Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a predictive and prognostic marker in newly diagnosed glioblastoma patients treated with temozolomide but how MGMT methylation should be assessed to ensure optimal detection accuracy is debated. We developed a novel quanti...

  6. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer

    NARCIS (Netherlands)

    Barault, L.; Amatu, A.; Bleeker, F. E.; Moutinho, C.; Falcomatà, C.; Fiano, V.; Cassingena, A.; Siravegna, G.; Milione, M.; Cassoni, P.; de Braud, F.; Rudà, R.; Soffietti, R.; Venesio, T.; Bardelli, A.; Wesseling, P.; de Witt Hamer, P.; Pietrantonio, F.; Siena, S.; Esteller, M.; Sartore-Bianchi, A.; Di Nicolantonio, F.

    2015-01-01

    O(6)-methyl-guanine-methyl-transferase (MGMT) silencing by promoter methylation may identify cancer patients responding to the alkylating agents dacarbazine or temozolomide. We evaluated the prognostic and predictive value of MGMT methylation testing both in tumor and cell-free circulating DNA

  7. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer

    NARCIS (Netherlands)

    Barault, L.; Amatu, A.; Bleeker, F. E.; Moutinho, C.; Falcomatà, C.; Fiano, V.; Cassingena, A.; Siravegna, G.; Milione, M.; Cassoni, P.; de Braud, F.; Rudà, R.; Soffietti, R.; Venesio, T.; Bardelli, A.; Wesseling, P.; de Witt Hamer, P.; Pietrantonio, F.; Siena, S.; Esteller, M.; Sartore-Bianchi, A.; di Nicolantonio, Federica

    2015-01-01

    Background: O6-methyl-guanine-methyl-transferase (MGMT) silencing by promoter methylation may identify cancer patients responding to the alkylating agents dacarbazine or temozolomide. Patients and methods: We evaluated the prognostic and predictive value of MGMT methylation testing both in tumor and

  8. Managerial accounting applications in radiology.

    Science.gov (United States)

    Lexa, Frank James; Mehta, Tushar; Seidmann, Abraham

    2005-03-01

    We review the core issues in managerial accounting for radiologists. We introduce the topic and then explore its application to diagnostic imaging. We define key terms such as fixed cost, variable cost, marginal cost, and marginal revenue and discuss their role in understanding the operational and financial implications for a radiology facility by using a cost-volume-profit model. Our work places particular emphasis on the role of managerial accounting in understanding service costs, as well as how it assists executive decision making.

  9. MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults.

    Science.gov (United States)

    Alvarez, Marisa C; Santos, Juliana C; Maniezzo, Nathália; Ladeira, Marcelo S; da Silva, Artur L C; Scaletsky, Isabel C A; Pedrazzoli, José; Ribeiro, Marcelo L

    2013-05-28

    To evaluate the association between Helicobacter pylori (H. pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability (MSI). The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction (MSP-PCR) in gastric biopsy samples from uninfected or H. pylori-infected children (n = 50), from adults with chronic gastritis (n = 97) and from adults with gastric cancer (n = 92). MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene (β actin). MSI analysis was performed by screening MSI markers at 4 loci (Bat-25, Bat-26, D17S250 and D2S123) with PCR; PCR products were analysed by single strand conformation polymorphism followed by silver staining. Statistical analyses were performed with either the χ(2) test with Yates continuity correction or Fisher's exact test, and statistical significance for expression analysis was assessed using an unpaired Student's t-test. Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children, regardless of H. pylori infection status. The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H. pylori infection (P MLH1 methylation frequencies among H. pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%, respectively. We observed methylation of the MLH1 promoter (39%) and increased MSI levels (68%) in samples from gastric cancer patients in comparison to samples from H. pylori-infected adult chronic gastritis patients (P MLH1 and MGMT mRNA were significantly reduced in chronic gastritis samples that were also hypermethylated (P MLH1 methylation did not occur in earlier-stage H. pylori infections and thus might depend on the duration of infection.

  10. Police, managerialization and presentational strategies

    NARCIS (Netherlands)

    Terpstra, J.; Trommel, W.A.

    2009-01-01

    Purpose - The managerialization of the police may be seen as an effort to restore the legitimacy of the police. This paper aims to show that the managerialist strategy presently occurring within police forces creates new pitfalls and unintended consequences. Design/methodology/approach - The paper

  11. Enhancing managerial effectiveness in dietetics.

    Science.gov (United States)

    Hoover, L W

    1983-01-01

    Environmental pressures from such sources as economic conditions, the government, third-party payers, and inter-institutional competition create managerial challenges. Although cost-containment has received considerable attention, long-term cost-effectiveness is probably the significant issue. Dietitians must become more cost-conscious and effective in resource management to attain desired performance outcomes. Some of the skills and characteristics essential to managerial effectiveness are a marketing orientation, systems design skill, quantitative operations management techniques, financial expertise, and leadership. These abilities facilitate decision-making and achievement of long-term cost-effectiveness. Curriculum enhancement and continuing education are two strategies for improving managerial competency in the dietetics profession. In dietetics education, study of management topics should be enhanced to provide more advanced coverage of management theories and quantitative models so that managerial performance can be at a higher level of sophistication and competency. To assure the viability of the dietetics profession, the emphasis on management must be more comprehensive and rigorous.

  12. Managerial Accounting. Course Administrative Manual.

    Science.gov (United States)

    Central Michigan Univ., Mount Pleasant. Inst. for Personal and Career Development.

    This manual is part of the materials for a college-level programmed course in managerial accounting and intended to aid instructors in helping students to work their way through the self-instructional study guide around which the course is organized. The manual describes the various materials and components used in the self-instructional sequence…

  13. Prognostic value of O‐6‐methylguanine–DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis

    DEFF Research Database (Denmark)

    Dahlrot, Rikke H; Dowsett, Joseph; Fosmark, Sigurd

    2018-01-01

    AIMS: It is important to predict response to treatment with temozolomide (TMZ) in glioblastoma (GBM) patients. Both MGMT protein expression and MGMT promoter methylation have been reported to predict the response to TMZ. We investigated the prognostic value of quantified MGMT protein levels...... in tumour cells and the prognostic importance of combining information of MGMT protein level and MGMT promoter methylations status. METHODS: MGMT protein expression was quantified in tumour cells in 171 GBMs from the population-based Region of Southern Denmark (RSD)-cohort using a double immunofluorescence...... approach. Pyrosequencing was performed in 157 patients. For validation we used GBM-patients from a Nordic Study (NS) investigating the effect of radiotherapy and different TMZ schedules. RESULTS: When divided at the median, patients with low expression of MGMT protein (AF-low) had the best prognosis (HR 1...

  14. Influence of promoter/enhancer region haplotypes on MGMT transcriptional regulation: a potential biomarker for human sensitivity to alkylating agents.

    Science.gov (United States)

    Xu, Meixiang; Nekhayeva, Ilona; Cross, Courtney E; Rondelli, Catherine M; Wickliffe, Jeffrey K; Abdel-Rahman, Sherif Z

    2014-03-01

    The O6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and their functional/biological significance are currently unknown. We hypothesized that MGMT P/E haplotypes, rather than individual SNPs, alter MGMT transcription and can thus alter human sensitivity to alkylating agents. To identify the haplotype structure encompassing the MGMT P/E region SNPs, we sequenced 104 DNA samples from healthy individuals and inferred the haplotypes using the data generated. We identified eight SNPs in this region, namely T7C (rs180989103), T135G (rs1711646), G290A (rs61859810), C485A (rs1625649), C575A (rs113813075), G666A (rs34180180), C777A (rs34138162) and C1099T (rs16906252). Phylogenetics and Sequence Evolution analysis predicted 21 potential haplotypes that encompass these SNPs ranging in frequencies from 0.000048 to 0.39. Of these, 10 were identified in our study population as 20 paired haplotype combinations. To determine the functional significance of these haplotypes, luciferase reporter constructs representing these haplotypes were transfected into glioblastoma cells and their effect on MGMT promoter activity was determined. Compared with the most common (reference) haplotype 1, seven haplotypes significantly upregulated MGMT promoter activity (18-119% increase; P alkylating agents.

  15. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

    Science.gov (United States)

    Esteller, M; Garcia-Foncillas, J; Andion, E; Goodman, S N; Hidalgo, O F; Vanaclocha, V; Baylin, S B; Herman, J G

    2000-11-09

    The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of the promoter silences the gene in cancer, and the cells no longer produce MGMT. We examined gliomas to determine whether methylation of the MGMT promoter is related to the responsiveness of the tumor to alkylating agents. We analyzed the MGMT promoter in tumor DNA by a methylation-specific polymerase-chain-reaction assay. The gliomas were obtained from patients who had been treated with carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea, or BCNU). The molecular data were correlated with the clinical outcome. The MGMT promoter was methylated in gliomas from 19 of 47 patients (40 percent). This finding was associated with regression of the tumor and prolonged overall and disease-free survival. It was an independent and stronger prognostic factor than age, stage, tumor grade, or performance status. Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents.

  16. Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide).

    Science.gov (United States)

    Pandith, Arshad A; Qasim, Iqbal; Zahoor, Wani; Shah, Parveen; Bhat, Abdul R; Sanadhya, Dheera; Shah, Zafar A; Naikoo, Niyaz A

    2018-04-30

    O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation and its subsequent loss of protein expression has been identified to have a variable impact on clinical outcome of glioma patients indicated for chemotherapy with alkylating agents (Temozolomide). This study investigated methylation status of MGMT gene along with in situ protein expression in malignant glioma patients of different histological types to evaluate the associated clinical outcome vis-a-vis use of alkylating drugs and radiotherapy. Sixty three cases of glioma were evaluated for MGMT promoter methylation by methylation-specific PCR (MS-PCR) and protein expression by immunostaining (IHC). Methylation status of MGMT and loss of protein expression showed a very high concordant association with better survival and progression free survival (PFS) (p < 0.0001). Multivariate Cox regression analysis showed both MGMT methylation and loss of protein as significant independent prognostic factors in glioma patients with respect to lower Hazard Ratio (HR) for better OS and PFS) [p < 0.05]. Interestingly concordant MGMT methylation and lack of protein showed better response in TMZ therapy treated patient subgroups with HR of 2.02 and 0.76 (p < 0.05). We found the merits of prognostication of MGMT parameters, methylation as well as loss of its protein as predictive factors for favorable outcome in terms of better survival for TMZ therapy.

  17. The importance of managerial accounting in managerial accounting system

    OpenAIRE

    Dragan Cristian

    2014-01-01

    In order to determine the role of Managerial Accounting in a company’s information system we must start with a systematic approach. According to systematic approach, this system is a structure that produces: - transformation; - self-adjusting; - synergy (the principle of totality). Therefore, considering the above, the total is higher than the sum of the component parts, when we are referring to plus- value creation.

  18. Can high-dose fotemustine reverse MGMT resistance in glioblastoma multiforme?

    Science.gov (United States)

    Gallo, Chiara; Buonerba, Carlo; Di Lorenzo, Giuseppe; Romeo, Valeria; De Placido, Sabino; Marinelli, Alfredo

    2010-11-01

    Glioblastoma multiforme (GBM), the highest grade malignant glioma, is associated with a grim prognosis-median overall survival is in the range 12-15 months, despite optimum treatment. Surgery to the maximum possible extent, external beam radiotherapy, and systemic temozolomide chemotherapy are current standard treatments for newly diagnosed GBM, with intracerebral delivery of carmustine wafers (Gliadel). Unfortunately, the effectiveness of chemotherapy can be hampered by the DNA repair enzyme O6-methylguanine methyltransferase (MGMT), which confers resistance both to temozolomide and nitrosoureas, for example fotemustine and carmustine. MGMT activity can be measured by PCR and immunohistochemistry, with the former being the current validated technique. High-dose chemotherapy can deplete MGMT levels in GBM cells and has proved feasible in various trials on temozolomide, in both newly diagnosed and recurrent GBM. We here report the unique case of a GBM patient, with high MGMT expression by immunohistochemistry, who underwent an experimental, high-dose fotemustine schedule after surgery and radiotherapy. Although treatment caused two episodes of grade 3-4 thrombocytopenia, a complete response and survival of more than three years were achieved, with a 30% increase in dose intensity compared with the standard fotemustine schedule.

  19. Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.

    Directory of Open Access Journals (Sweden)

    João Ramalho-Carvalho

    Full Text Available MGMT downregulation in high-grade gliomas (HGG has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to alkylating agent-based chemotherapy. However, HGG harboring 10q deletions also benefit from treatment with alkylating agents. Because the MGMT gene is mapped at 10q26, we hypothesized that both epigenetic and genetic alterations might affect its expression and predict response to chemotherapy. To test this hypothesis, promoter methylation and mRNA levels of MGMT were determined by quantitative methylation-specific PCR (qMSP or methylation-specific multiplex ligation dependent probe amplification (MS-MLPA and quantitative RT-PCR, respectively, in a retrospective series of 61 HGG. MGMT/chromosome 10 copy number variations were determined by FISH or MS-MLPA analysis. Molecular findings were correlated with clinical parameters to assess their predictive value. Overall, MGMT methylation ratios assessed by qMSP and MS-MLPA were inversely correlated with mRNA expression levels (best coefficient value obtained with MS-MLPA. By FISH analysis in 68.3% of the cases there was loss of 10q26.1 and in 15% of the cases polysomy was demonstrated; the latter displayed the highest levels of transcript. When genetic and epigenetic data were combined, cases with MGMT promoter methylation and MGMT loss depicted the lowest transcript levels, although an impact in response to alkylating agent chemotherapy was not apparent. Cooperation between epigenetic (promoter methylation and genetic (monosomy, locus deletion changes affecting MGMT in HGG is required for effective MGMT silencing. Hence, evaluation of copy number alterations might add relevant prognostic and predictive information concerning response to alkylating agent-based chemotherapy.

  20. MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response.

    Science.gov (United States)

    Switzeny, Olivier J; Christmann, Markus; Renovanz, Mirjam; Giese, Alf; Sommer, Clemens; Kaina, Bernd

    2016-01-01

    The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are routinely treated with alkylating drugs. Since MGMT is highly epigenetically regulated, the MGMT promoter methylation status is taken as an indicator of MGMT silencing, predicting the outcome of glioma therapy. MGMT promoter methylation is usually determined by methylation specific PCR (MSP), which is a labor intensive and error-prone method often used semi-quantitatively. Searching for alternatives, we used closed-tube high resolution melt (HRM) analysis, which is a quantitative method, and compared it with MSP and pyrosequencing regarding its predictive value. We analyzed glioblastoma cell lines with known MGMT activity and formalin-fixed samples from IDH1 wild-type high-grade glioma patients (WHO grade III/IV) treated with radiation and temozolomide by HRM, MSP, and pyrosequencing. The data were compared as to progression-free survival (PFS) and overall survival (OS) of patients exhibiting the methylated and unmethylated MGMT status. A promoter methylation cut-off level relevant for PFS and OS was determined. In a multivariate Cox regression model, methylation of MGMT promoter of high-grade gliomas analyzed by HRM, but not MSP, was found to be an independent predictive marker for OS. Univariate Kaplan-Meier analyses revealed for PFS and OS a significant and better discrimination between methylated and unmethylated tumors when quantitative HRM was used instead of MSP. Compared to MSP and pyrosequencing, the HRM method is simple, cost effective, highly accurate and fast. HRM is at least equivalent to pyrosequencing in quantifying the methylation level. It is superior in predicting PFS and OS of high-grade glioma patients compared to MSP and, therefore, can be recommended being used routinely for determination of the MGMT status of gliomas.

  1. Impact of Therapy Sequence with Alkylating Agents and MGMT Status in Patients with Advanced Neuroendocrine Tumors.

    Science.gov (United States)

    Krug, Sebastian; Boch, Michael; Rexin, Peter; Gress, Thomas M; Michl, Patrick; Rinke, Anja

    2017-05-01

    Alkylating chemotherapeutics with either a streptozotocin-(STZ) or temozolomide-(TEM) backbone are routinely used in patients with progressive and unresectable pancreatic neuroendocrine tumors (PNET). In addition, dacarbazine (DTIC) was described as an alternative alkylating therapy option for PNETs. The optimal treatment sequence with alkylating compounds and a potential use of O6-methylguanine-DNA methyltransferase (MGMT) level as predictive biomarker have not yet been sufficiently elucidated. The aim of our study was the evaluation of therapy sequence with either STZ-based treatment followed by DTIC (group A) or the inverse schedule with upfront DTIC (group B) and to correlate MGMT status with clinicopathological characteristics and response to therapy. We retrospectively analyzed 28 patients with neuroendocrine tumors (NET) who were treated with STZ-based therapy and DTIC. Additionally, in a second group MGMT immunohistochemistry was performed from primary and metastatic tumor sites. For statistical evaluation Kaplan-Meier analysis, Cox regression methods and Fisher's exact test were used. There was no difference of objective response and disease control between either STZ-based therapy followed by DTIC treatment (group A) after progression or the reverse sequence (group B). Median time to progression (TTP) was estimated to be 21 months in both arms. First-line STZ-based chemotherapy was not superior to first-line DTIC treatment (16 vs. 13 months; p=0.8). MGMT status did not correlate with clinicopathological characteristics or response to therapy with these alkylating agents. Upfront chemotherapy with either STZ-based treatment or DTIC monotherapy showed similar efficacy and median TTP rates. In this study, MGMT protein expression assessed by immunohistochemistry did not play an important role as a predictive marker for alkylating agents. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  2. Managerial Methodology in Public Institutions

    Directory of Open Access Journals (Sweden)

    Ion VERBONCU

    2010-10-01

    Full Text Available One of the most important ways of making public institutions more efficient is by applying managerial methodology, embodied in the promotion of management tools, modern and sophisticated methodologies, as well as operation of designing/redesigning and maintenance of the management process and its components. Their implementation abides the imprint of constructive and functional particularities of public institutions, decentralized and devolved, and, of course, the managers’ expertise of these organizations. Managerial methodology is addressed through three important instruments diagnosis, management by objectives and scoreboard. Its presence in the performance management process should be mandatory, given the favorable influence on the management and economic performance and the degree of scholastic approach of the managers’ performance.

  3. Managerial Decision Making in Traffic

    Directory of Open Access Journals (Sweden)

    Teodor Perić

    2003-11-01

    Full Text Available Decision-making is defined as a selection of a certain actionamong several alternatives. It is the essence of planning, asin the managerial sense there is no plan until a decision of engagementof resources, reputation and direction of activities ismade. Decision-making is, in fact, only a step in planning, evenwhen it is performed quickly and without special consideration.It is what we all experience every day. It is one of the most fascinatingbiological activities and the subject of frightening implicationsfor the whole human race. Since various techniques improvethe system and the quality of managerial decision-making,they are classified into three assumptions: risk analysis, decision-making trees, and the theory of revealed preference. Allof these are based on the interaction of a certain number of importantvariables out of which many contain the elements ofuncertainty, but maybe also high level of probability.

  4. Managerial Distance and Virtual Ownership

    DEFF Research Database (Denmark)

    Hansmann, Henry; Thomsen, Steen

    Industrial foundations are autonomous nonprofit entities that own and control one or more conventional business firms. These foundations are common in Northern Europe, where they own a number of internationally prominent companies. Previous studies have indicated, surprisingly, that companies con......, but corporate governance and fiduciary behavior more generally....... on differences among the industrial foundations themselves. We work with a rich data set comprising 113 foundation-owned Danish companies over the period 2003-2008. We focus in particular on a composite structural factor that we term “managerial distance.” We propose this as a measure of the extent to which......-seeking outside owners of the company. Consistent with this hypothesis, our empirical analysis shows a positive, significant, and robust association between managerial distance and the economic performance of foundation owned companies. The findings appear to illuminate not just foundation governance...

  5. Managerial competencies in Operations Management

    Directory of Open Access Journals (Sweden)

    Carmen Gonzalez-Zapatero

    2017-06-01

    Full Text Available The main objective of this paper is to develop a method of self-assessment of managerial competencies in Operations Management. Specifically we work the following skills: Analytical Consideration, Planification and organization, Consciousness and teamwork, Adaptability, Assertiveness, Leadership. The empirical evidence shows how some of these abilities are related to the results of the course while no relation was found with the results obtained with the results the rest of the degree.

  6. Mergers, managerial incentives, and efficiencies

    OpenAIRE

    Jovanovic, Dragan

    2014-01-01

    We analyze the effects of synergies from horizontal mergers in a Cournot oligopoly where principals provide their agents with incentives to cut marginal costs prior to choosing output. We stress that synergies come at a cost which possibly leads to a countervailing incentive effect: The merged firm's principal may be induced to stifle managerial incentives in order to reduce her agency costs. Whenever this incentive effect dominates the well-known direct synergy effect, synergies actually red...

  7. Two managerial grids in NPP

    International Nuclear Information System (INIS)

    Zhao Hui

    2012-01-01

    Today, the nuclear power corporation (NPC) enjoys the profit of LCEP (the low carbon economic policy). at the same time, they also enduring more and more pressure. For example, the partner competition or the NPP potential occupational risk . The efficient counterplot of risk is the self-ability cultivation. It is essential to research the NPP managerial flow. The nuclear power plant (NPP) unit is a carrier of the NPC enterprise management system, and has taken on a new look 'pull one portion then the whole moving'. The NPP has three systematical characters, the security responsibility center, the man-machine system and the input-output system. The manufacturing system and the enterprise management system are the great constituents of the NPP managerial flows. Means of systems analysis, we can find out the truth of the NPP running interface. In CHINA, there are many operating experiences near 20 years. It indicates that the NPP manufacturing system and the enterprise system are the roots of the nuclear power corporation, the core of the all NPP systems must be based on it. So the ability cultivation is the work core to NPP. It is reliably to ensure the NPP to be up against problems, for instance, the security duty, the costing control and the man-machine system running harmoniously. This paper introduces the NPP managerial flow and the present state of QNPC, also come up with a proposal to refer for the NPC development actions of collective measure, specialization, standardization, fine. (author)

  8. Modelling of functional systems of managerial accounting

    Directory of Open Access Journals (Sweden)

    O.V. Fomina

    2017-12-01

    Full Text Available The modern stage of managerial accounting development takes place under the powerful influence of managerial innovations. The article aimed at the development of integrational model of budgeting and the system of balanced indices in the system of managerial accounting that will contribute the increasing of relevance for making managerial decisions by managers of different levels management. As a result of the study the author proposed the highly pragmatical integration model of budgeting and system of the balanced indices in the system of managerial accounting, which is realized by the development of the system of gathering, consolidation, analysis, and interpretation of financial and nonfinancial information, contributes the increasing of relevance for making managerial decisions on the base of coordination and effective and purpose orientation both strategical and operative resources of an enterprise. The effective integrational process of the system components makes it possible to distribute limited resources rationally taking into account prospective purposes and strategic initiatives, to carry

  9. Managerial attitude toward quality assurance

    International Nuclear Information System (INIS)

    Kirschenmann, H.J.

    1983-01-01

    This paper will present what relationships exist between the attitude toward quality assurance and the variables of training and experience on the part of managers within the nuclear power industry. Managerial attitude toward quality assurance was measured via questionnaires submitted to managers within architect-engineering, nuclear steam supplier, and constructor firms throughout the United States. The data from the completed questionnaires were statistically analyzed using the chi-square test and conclusions were drawn. Additional study results related to major factors for positive and negative attitudes toward quality assurance will be presented

  10. A managerial modernization model in crisis conditions

    OpenAIRE

    Ion VERBONCU; Ion PURCARU

    2009-01-01

    The improvement of the economic performances of Romanian enterprises facing crisis conditions could be achieved by means of promoting and implementing a range of managerial modernization methods. Among them we mention several factors pertaining to strategic management: redesigning the managerial system, implementing methodological management – with an emphasis on profit center management and other managerial tools which ensure process and organizational flexibility – and professionalizing...

  11. ABERRANT METHYLATION OF THE PROMOTER OF APC, CDH13 AND MGMT GENES IN COLORECTAL CANCER PATIENTS

    Directory of Open Access Journals (Sweden)

    O. I. Kit

    2016-01-01

    Full Text Available Aberrant methylation of gene promoter regions is the main epigenetic change characterizing colorectal cancer. Methylation levels of 42 CpG-sites of promoter regions of the MGMT, APC and CDH13 genes in colorectal cancer were studied in comparison with methylation levels of the adjacent normal tissue in 25 patients. Pyrosequencing showed an increase in methylation levels of promoter regions of the MGMT, APC and CDH13 genes in tumor samples by 3 to 5 times. These tumor samples were screened for activating SNP-mutations in the KRAS (40 %, NRAS (0 % and BRAF (0 % oncogenes. SNP-mutations in the KRAS gene were accompanied by hypermethylation of one or more promoters of the studied genes. Association of this epigenetic index with tumor metastasis was proved. The data on an increase in methylation of the promoter regions of oncosupressor genes can be used as sensitive prognostic markers of progression and metastasis of colorectal cancer.

  12. Isocitrate dehydrogenase 1 and 2 genes mutations and MGMT methylation in gliomas

    Directory of Open Access Journals (Sweden)

    D. V. Tabakov

    2017-01-01

    Full Text Available Gliomas are the most common brain tumors. It is difficult to detect them at early stages of disease and there is a few available therapies providing significant improvement in survival. Mutations of isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2 play significant role in gliomogenesis, diagnostics and selection of patient therapy. We tested the distribution of IDH1 and IDH2 mutations in gliomas of different histological types and grades of malignancy by DNA melting analysis using our protocol with a sensitivity of 5 %. The results of this assay were confirmed by conventional Sanger sequencing. IDH1/2 mutations were detected in 74 % of lower grade gliomas (II and III, World Health Organization and in 14 % of glioblastomas (IV, World Health Organization. Mutation rate in gliomas with oligodendroglioma component were significantly higher then in other glioma types (р = 0.014. The IDH1 mutations was the most common (79 % of general mutation number. IDH1/2 mutations can induce aberrant gene methylation. Detection of methylation rate of the gene encoding for O6-methylguanine-DNA-methyltransferase (MGMT, predictive biomarker for treatment of gliomas with the alkylating agents, has demonstrated a partial association with IDH1/2 mutations. In 73 % of IDH1/2-mutant tumors MGMT promoter methylation were observed. At the same time IDH1/2 mutations were not revealed in 67 % tumors with MGMT promoter methylation. These results indicate existence of another mechanism of MGMT methylation in gliomas. Our data strong support for necessity of both markers testing when patient therapy is selected.

  13. Using the apparent diffusion coefficient to identifying MGMT promoter methylation status early in glioblastoma: importance of analytical method

    Energy Technology Data Exchange (ETDEWEB)

    Rundle-Thiele, Dayle [Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia); Day, Bryan; Stringer, Brett [Brain Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland (Australia); Fay, Michael [Department of Radiation Oncology, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Martin, Jennifer [Discipline of Clinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales (Australia); Jeffree, Rosalind L [Department of Neurosurgery, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Thomas, Paul [Queensland PET Service, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Bell, Christopher [Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia); Salvado, Olivier [CSIRO Digital Productivity Flagship, CSIRO, Herston, Queensland (Australia); Gal, Yaniv [Centre for Medical Diagnostic Technologies in Queensland, University of Queensland, Brisbane, Queensland (Australia); Coulthard, Alan [Discipline of Medical Imaging, University of Queensland, St Lucia, Queensland (Australia); Department of Medical Imaging, Royal Brisbane and Women' s Hospital, Brisbane, Queensland (Australia); Crozier, Stuart [Centre for Medical Diagnostic Technologies in Queensland, University of Queensland, Brisbane, Queensland (Australia); Rose, Stephen, E-mail: stephen.rose@csiro.au [CSIRO Digital Productivity Flagship, CSIRO, Herston, Queensland (Australia); Centre for Clinical Research, University of Queensland, Brisbane, Queensland (Australia)

    2015-06-15

    Accurate knowledge of O{sup 6}-methylguanine methyltransferase (MGMT) gene promoter subtype in patients with glioblastoma (GBM) is important for treatment. However, this test is not always available. Pre-operative diffusion MRI (dMRI) can be used to probe tumour biology using the apparent diffusion coefficient (ADC); however, its ability to act as a surrogate to predict MGMT status has shown mixed results. We investigated whether this was due to variations in the method used to analyse ADC. We undertook a retrospective study of 32 patients with GBM who had MGMT status measured. Matching pre-operative MRI data were used to calculate the ADC within contrast enhancing regions of tumour. The relationship between ADC and MGMT was examined using two published ADC methods. A strong trend between a measure of ‘minimum ADC’ and methylation status was seen. An elevated minimum ADC was more likely in the methylated compared to the unmethylated MGMT group (U = 56, P = 0.0561). In contrast, utilising a two-mixture model histogram approach, a significant reduction in mean measure of the ‘low ADC’ component within the histogram was associated with an MGMT promoter methylation subtype (P < 0.0246). This study shows that within the same patient cohort, the method selected to analyse ADC measures has a significant bearing on the use of that metric as a surrogate marker of MGMT status. Thus for dMRI data to be clinically useful, consistent methods of data analysis need to be established prior to establishing any relationship with genetic or epigenetic profiling.

  14. Using the apparent diffusion coefficient to identifying MGMT promoter methylation status early in glioblastoma: importance of analytical method

    International Nuclear Information System (INIS)

    Rundle-Thiele, Dayle; Day, Bryan; Stringer, Brett; Fay, Michael; Martin, Jennifer; Jeffree, Rosalind L; Thomas, Paul; Bell, Christopher; Salvado, Olivier; Gal, Yaniv; Coulthard, Alan; Crozier, Stuart; Rose, Stephen

    2015-01-01

    Accurate knowledge of O 6 -methylguanine methyltransferase (MGMT) gene promoter subtype in patients with glioblastoma (GBM) is important for treatment. However, this test is not always available. Pre-operative diffusion MRI (dMRI) can be used to probe tumour biology using the apparent diffusion coefficient (ADC); however, its ability to act as a surrogate to predict MGMT status has shown mixed results. We investigated whether this was due to variations in the method used to analyse ADC. We undertook a retrospective study of 32 patients with GBM who had MGMT status measured. Matching pre-operative MRI data were used to calculate the ADC within contrast enhancing regions of tumour. The relationship between ADC and MGMT was examined using two published ADC methods. A strong trend between a measure of ‘minimum ADC’ and methylation status was seen. An elevated minimum ADC was more likely in the methylated compared to the unmethylated MGMT group (U = 56, P = 0.0561). In contrast, utilising a two-mixture model histogram approach, a significant reduction in mean measure of the ‘low ADC’ component within the histogram was associated with an MGMT promoter methylation subtype (P < 0.0246). This study shows that within the same patient cohort, the method selected to analyse ADC measures has a significant bearing on the use of that metric as a surrogate marker of MGMT status. Thus for dMRI data to be clinically useful, consistent methods of data analysis need to be established prior to establishing any relationship with genetic or epigenetic profiling

  15. Iinformation accessibility and farmers manageriability of guinea ...

    African Journals Online (AJOL)

    The study examined the farmers' access to information and their manageriability of the intervention programme in the study area. To achieve the objective, there was need to determine farmers' information accessibility and manageriability of guinea worm intervention package; then determine farmers satisfaction with the ...

  16. No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

    Science.gov (United States)

    Doak, Shareen H; Brüsehafer, Katja; Dudley, Ed; Quick, Emma; Johnson, George; Newton, Russell P; Jenkins, Gareth J S

    2008-12-15

    The alkylating agents methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS) have non-linear dose-response curves, with a no-observed effect level (NOEL) and a lowest observed effect level (LOEL) for both gross chromosomal damage and mutagenicity. However, the biological mechanism responsible for the NOEL has yet to be identified. A strong candidate is DNA repair as it may be able to efficiently remove alkyl adducts at low doses resulting in a NOEL, but at higher doses fails to fully remove all lesions due to saturation of enzymatic activity resulting in a LOEL and subsequent linear increases in mutagenicity. We therefore assessed the transcriptional status of N-methylpurine-DNA glycoslase (MPG) and O(6)-methylguanine DNA methyltransferase (MGMT), which represent the first line of defence following exposure to alkylating agents through the respective enzymatic removal of N7-alkylG and O(6)-alkylG. The relative MPG and MGMT gene expression profiles were assessed by real-time RT-PCR following exposure to 0-2 microg/ml MMS for 1-24h. MPG expression remained fairly steady, but in contrast significant up-regulation of MGMT was observed when cells were treated with 0.5 and 1.0 microg/ml MMS for 4h (2.5- and 6.5-fold increases respectively). These doses lie within the NOEL for MMS mutagenicity (LOEL is 1.25 microg/ml), thus this boost in MGMT expression at low doses may be responsible for efficiently repairing O(6)methylG lesions and creating the non-linear response for mutations. However, as the LOEL for MMS clastogenicity is 0.85 microg/ml, O(6)-alkylG is unlikely to be responsible for the clastogenicity observed at these concentrations. Consequently, at low doses N7-methylG is possibly the predominant cause of MMS clastogenicity, while O(6)-methylG is more likely to be responsible for MMS mutagenicity, with MGMT up-regulation playing a key role in removal of O(6)-alkylG lesions before they are fixed as permanent point mutations, resulting in non-linear dose

  17. Managerial Leadership - A Theoretical Approach

    Directory of Open Access Journals (Sweden)

    Felicia Cornelia MACARIE

    2007-06-01

    Full Text Available The paper endeavors to offer an overview of the major theories on leadership and the way in which it influences the management of contemporary organizations. Numerous scholars highlight that there are numerous overlaps between the concepts of management and leadership. This is the reason why the first section of the paper focuses on providing an extensive overview of the literature regarding the meaning of the two aforementioned concepts. The second section addresses more in depth the concept of leadership and managerial leadership and focuses on the ideal profile of the leader. The last section of the paper critically discusses various types of leadership and more specifically modern approaches to the concept and practices of leadership.

  18. Peer Influence on Managerial Honesty

    DEFF Research Database (Denmark)

    Brunner, Markus; Ostermaier, Andreas

    2018-01-01

    peers’ reports are higher than they have expected, the opposite is not true. Third, partial transparency reinforces this asymmetry in peer influence. Unlike full transparency, it allows managers to substitute self-serving assumptions for missing information and to thus justify their own dishonesty more......We investigate peer influence on managerial honesty under varying levels of transparency. In a laboratory experiment, managers report their costs to a superior to request budget. We manipulate whether the managers learn each other’s report and cost (full transparency) or the report but not the cost...... (partial transparency). The results show, first, that managers are susceptible to peer influence, as they join peers in reporting honestly and dishonestly both under full and partial transparency. Second, however, the effect of peer influence is asymmetric. While managers’ dishonesty increases much when...

  19. S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells

    Directory of Open Access Journals (Sweden)

    AGM Mostofa

    2018-04-01

    Full Text Available Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma and other cancer cell lines. MGMT protein was shown to harbor a nearly perfect PCNA-Interacting Protein (PIP box motif. Isogenic p53-null H1299 cells were engineered to express the p21 protein by two different procedures. Reciprocal immunoprecipitation/western blotting, Far-western blotting, and confocal microscopy confirmed the specific association of MGMT with PCNA and the ability of p21 to strongly disrupt the MGMT-PCNA complexes in tumor cells. Alkylation DNA damage resulted in a greater colocalization of MGMT and PCNA proteins, particularly in HCT116 cells deficient in p21 expression. p21 expression in isogenic cell lines directly correlated with markedly higher levels of MGMT mRNA, protein, activity and greater resistance to alkylating agents. In other experiments, four glioblastoma cell lines synchronized at the G1/S phase using either double thymidine or thymidine-mimosine blocks and subsequent cycling consistently showed a loss of MGMT protein at mid- to late S-phase, irrespective of the cell line, suggesting such a downregulation is fundamental to cell cycle control. MGMT protein was also specifically degraded in extracts from S-phase cells and evidence strongly suggested the involvement of PCNA-dependent CRL4Cdt2 ubiquitin-ligase in the reaction. Overall, these data provide the first evidence for non-repair functions of MGMT in cell cycle and highlight the involvement of PCNA in MGMT downregulation, with p21 attenuating the process.

  20. Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells

    International Nuclear Information System (INIS)

    Cheng, Jin; Ye, Feng; Dan, Guorong; Zhao, Yuanpeng; Wang, Bin; Zhao, Jiqing; Sai, Yan; Zou, Zhongmin

    2016-01-01

    Nitrogen mustard (NM), a bifunctional alkylating agent (BAA), contains two alkyl arms and can act as a cross-linking bridge between DNA and protein to form a DNA-protein cross-link (DPC). O 6 -methylguanine–DNA methyltransferase (MGMT), a DNA repair enzyme for alkyl adducts removal, is found to enhance cell sensitivity to BAAs and to promote damage, possibly due to its stable covalent cross-linking with DNA mediated by BAAs. To investigate MGMT-DNA cross-link (mDPC) formation and its possible dual roles in NM exposure, human bronchial epithelial cell line 16HBE was subjected to different concentrations of HN2, a kind of NM, and we found mDPC was induced by HN2 in a concentration-dependent manner, but the mRNA and total protein of MGMT were suppressed. As early as 1 h after HN2 treatment, high mDPC was achieved and the level maintained for up to 24 h. Quick total DPC (tDPC) and γ-H2AX accumulation were observed. To evaluate the effect of newly predicted protease DVC1 on DPC cleavage, we applied siRNA of MGMT and DVC1, MG132 (proteasome inhibitor), and NMS-873 (p97 inhibitor) and found that proteolysis plays a role. DVC1 was proven to be more important in the cleavage of mDPC than tDPC in a p97-dependent manner. HN2 exposure induced DVC1 upregulation, which was at least partially contributed to MGMT cleavage by proteolysis because HN2-induced mDPC level and DNA damage was closely related with DVC1 expression. Homologous recombination (HR) was also activated. Our findings demonstrated that MGMT might turn into a DNA damage promoter by forming DPC when exposed to HN2. Proteolysis, especially DVC1, plays a crucial role in mDPC repair. - Highlights: • Nitrogen mustard-induced MGMT-DNA cross-linking was detected in a living cell. • Concentration- and time-dependent manners of MGMT-DNA cross-linking were revealed. • Proteolysis played an important role in protein (MGMT)-DNA cross-linking repair. • DVC1 acts as a proteolytic enzyme in cross-linking repair in a p

  1. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.

    Science.gov (United States)

    Barault, L; Amatu, A; Bleeker, F E; Moutinho, C; Falcomatà, C; Fiano, V; Cassingena, A; Siravegna, G; Milione, M; Cassoni, P; De Braud, F; Rudà, R; Soffietti, R; Venesio, T; Bardelli, A; Wesseling, P; de Witt Hamer, P; Pietrantonio, F; Siena, S; Esteller, M; Sartore-Bianchi, A; Di Nicolantonio, F

    2015-09-01

    O(6)-methyl-guanine-methyl-transferase (MGMT) silencing by promoter methylation may identify cancer patients responding to the alkylating agents dacarbazine or temozolomide. We evaluated the prognostic and predictive value of MGMT methylation testing both in tumor and cell-free circulating DNA (cfDNA) from plasma samples using an ultra-sensitive two-step digital PCR technique (methyl-BEAMing). Results were compared with two established techniques, methylation-specific PCR (MSP) and Bs-pyrosequencing. Thresholds for MGMT methylated status for each technique were established in a training set of 98 glioblastoma (GBM) patients. The prognostic and the predictive value of MGMT methylated status was validated in a second cohort of 66 GBM patients treated with temozolomide in which methyl-BEAMing displayed a better specificity than the other techniques. Cutoff values of MGMT methylation specific for metastatic colorectal cancer (mCRC) tissue samples were established in a cohort of 60 patients treated with dacarbazine. In mCRC, both quantitative assays methyl-BEAMing and Bs-pyrosequencing outperformed MSP, providing better prediction of treatment response and improvement in progression-free survival (PFS) (P alkylating agents. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  2. A Hypermethylated Phenotype Is a Better Predictor of Survival than MGMT Methylation in Anaplastic Oligodendroglial Brain Tumors: A Report from EORTC Study 26951

    NARCIS (Netherlands)

    Bent, M.J. van den; Gravendeel, L.A.; Gorlia, T.; Kros, J.M.; Lapre, L.; Wesseling, P.; Teepen, J.L.; Idbaih, A.; Sanson, M.; Smitt, P.A.; French, P.J.

    2011-01-01

    PURPOSE: The MGMT promoter methylation status has been suggested to be predictive for outcome to temozolomide chemotherapy in patients with glioblastoma (GBM). Subsequent studies indicated that MGMT promoter methylation is a prognostic marker even in patients treated with radiotherapy alone, both in

  3. GROUPWARE - MODERN INFORMATION MANAGERIAL METHOD

    Directory of Open Access Journals (Sweden)

    Rozalia NISTOR

    2006-01-01

    Full Text Available The notion groupware contents the information technologies that facilitate theteam work and that are intended for communication, collaboration,coordination within the organization. Having as base software routines forteamwork, the groupware technology has many applications in themanagement process of the organization. The notion groupware refers to aspecial class of web packages connected to a network of personalcomputers: email, chat, video IP, newsgroups, etc. The studies from theliterature consider the groupware as a class of software programs thatfacilitate the coordination, the communication and the cooperation within themember of a group. As in marketing the marketing-mix is known as the “4P”,in the area of groupware its characteristics are known as the “3C”:communication within the group; coordination among the members of thegroup; collaboration among the members of the group. From the groupwaresoftware those with relevance for the managerial activity are: electronic mail,Internet meetings, time management, project management, the managementof dissimulated information. The groupware technologies can be divised inmany categories based on two elements: time and space. The users of agroupware work together in the same time – real time groupware, or invarious periods of time – offline groupware.

  4. Differential Radiosensitizing Potential of Temozolomide in MGMT Promoter Methylated Glioblastoma Multiforme Cell Lines

    International Nuclear Information System (INIS)

    Nifterik, Krista A. van; Berg, Jaap van den; Stalpers, Lukas J.A.; Lafleur, M. Vincent M.; Leenstra, Sieger; Slotman, Ben J.; Hulsebos, Theo J.M.; Sminia, Peter

    2007-01-01

    Purpose: To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and fractionated γ-irradiation. Methods and Materials: Three genetically characterized human GBM cell lines (AMC-3046, VU-109, and VU-122) were exposed to various single (0-6 Gy) and daily fractionated doses (2 Gy per fraction) of γ-irradiation. Repeated TMZ doses were given before and concurrent with irradiation treatment. Immediately plated clonogenic cell-survival curves were determined for both the single-dose and the fractionated irradiation experiments. To establish the net effect of clonogenic cell survival and cell proliferation, growth curves were determined, expressed as the number of surviving cells. Results: All three cell lines showed MGMT promoter methylation, lacked MGMT protein expression, and were sensitive to TMZ. The isotoxic TMZ concentrations used were in a clinically feasible range of 10 μmol/L (AMC-3046), 3 μmol/L (VU-109), and 2.5 μmol/L (VU-122). Temozolomide was able to radiosensitize two cell lines (AMC 3046 and VU-122) using single-dose irradiation. A reduction in the number of surviving cells after treatment with the combination of TMZ and fractionated irradiation was seen in all three cell lines, but only AMC 3046 showed a radiosensitizing effect. Conclusions: This study on TMZ-sensitive GBM cell lines shows that TMZ can act as a radiosensitizer and is at least additive to γ-irradiation. Enhancement of the radiation response by TMZ seems to be independent of the epigenetically silenced MGMT gene

  5. O6-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C

    International Nuclear Information System (INIS)

    Passagne, Isabelle; Evrard, Alexandre; Depeille, Philippe; Cuq, Pierre; Cupissol, Didier; Vian, Laurence

    2006-01-01

    Alkylating agents play an important role in the chemotherapy of malignant melanomas. The activity of alkylating agents depends on their capacity to form alkyl adducts with DNA, in some cases causing cross-linking of DNA strands. However, the use of these agents is limited by cellular resistance induced by the DNA repair enzyme O 6 -methylguanine DNA-methyltransferase (MGMT) which removes alkyl groups from alkylated DNA strands. To determine to what extent the expression of MGMT in melanoma cells induces resistance to alkylating agents, the human cell line CAL77 Mer- (i.e., MGMT deficient) were transfected with pcMGMT vector containing human MGMT cDNA. Several clones expressing MGMT at a high level were selected to determine their sensitivity to chemotherapeutic drugs. Melanoma-transfected cells were found to be significantly less sensitive to nitrosoureas (carmustine, fotemustine, streptozotocin) and temozolomide with an increase of IC 5 values between 3 and 14 when compared to parent cells. No difference in cell survival rates between MGMT-proficient and -deficient cells was observed for melphalan, chlorambucil, busulphan, thiotepa and cisplatin which preferentially induce N 7 guanine lesions. Surprisingly, MGMT overexpression increased the sensitivity of CAL77 cells to mitomycin C by approximately 10-fold. Treatment of clonal cell lines with buthionine-[S,R]-sulfoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase which depletes cellular glutathione, completely reversed this unexpected increase in sensitivity to mitomycin C. This observation suggests that glutathione is involved in the sensitivity of MGMT-transfected cells to mitomycin C and may act synergistically with MGMT via an unknown mechanism

  6. O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.

    Science.gov (United States)

    Passagne, Isabelle; Evrard, Alexandre; Depeille, Philippe; Cuq, Pierre; Cupissol, Didier; Vian, Laurence

    2006-03-01

    Alkylating agents play an important role in the chemotherapy of malignant melanomas. The activity of alkylating agents depends on their capacity to form alkyl adducts with DNA, in some cases causing cross-linking of DNA strands. However, the use of these agents is limited by cellular resistance induced by the DNA repair enzyme O(6)-methylguanine DNA-methyltransferase (MGMT) which removes alkyl groups from alkylated DNA strands. To determine to what extent the expression of MGMT in melanoma cells induces resistance to alkylating agents, the human cell line CAL77 Mer- (i.e., MGMT deficient) were transfected with pcMGMT vector containing human MGMT cDNA. Several clones expressing MGMT at a high level were selected to determine their sensitivity to chemotherapeutic drugs. Melanoma-transfected cells were found to be significantly less sensitive to nitrosoureas (carmustine, fotemustine, streptozotocin) and temozolomide with an increase of IC(50) values between 3 and 14 when compared to parent cells. No difference in cell survival rates between MGMT-proficient and -deficient cells was observed for melphalan, chlorambucil, busulphan, thiotepa and cisplatin which preferentially induce N(7) guanine lesions. Surprisingly, MGMT overexpression increased the sensitivity of CAL77 cells to mitomycin C by approximately 10-fold. Treatment of clonal cell lines with buthionine-[S,R]-sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase which depletes cellular glutathione, completely reversed this unexpected increase in sensitivity to mitomycin C. This observation suggests that glutathione is involved in the sensitivity of MGMT-transfected cells to mitomycin C and may act synergistically with MGMT via an unknown mechanism.

  7. Women in Managerial Positions in Greek Education.

    Science.gov (United States)

    Athanassoula-Reppa, Anastasia; Koutouzis, Manolis

    2002-01-01

    Discusses the under representation of women in managerial positions in Greece and the evidence of barriers that inhibit women from pursuing and taking such positions, a type of covert discrimination that is counter to notions of democratic citizenship. (SLD)

  8. Job sharing at the managerial level.

    Science.gov (United States)

    Acorn, S; Williams, J; Dempster, L; Provost, S; McEwan, C

    1997-05-01

    Job sharing restructures a full-time position-two individuals share the responsibilities and the benefits of the position. If nurses are committed to making it work, this arrangement can succeed at the managerial level.

  9. Managerial Meta-knowledge, Uncertainty, and Adaptation

    DEFF Research Database (Denmark)

    Jensen, Henrik; Foss, Nicolai Juul

    "Managerial Meta-Knowledge, Uncertainty, and Adaptation: Governance Choice when Firms do not Know their Capabilities" Much research on economic organization (e.g., transaction cost economics) is based on an assumption that firms accurately know their own capabilities. In terms of what managers know...... about the resources of the firm (including employee knowledge) we argue that this amounts to an assumption of perfect managerial meta-knowledge. However, research streams on resource cognition, transaction memory and organizational self- knowledge suggests that this assumption is not in general...... warranted. We examine the implications for economic organization of less-than-perfect managerial meta-knowledge. Specifically, we show that imperfect managerial meta- knowledge is a cause of surprises in contractual relationships, affects the ability of coordinated adaptation, and an opportunism...

  10. Improving Communication Within a Managerial Workgroup

    Science.gov (United States)

    Harvey, Jerry B.; Boettger, C. Russell

    1971-01-01

    This paper describes an experiment involving the use of laboratory education (Bradford, Gibb, & Benne, 1964; Bennis & Schein, 1965) and was designed on the assumption that improvement of communication in managerial workgroups enhances task effectiveness. (Author)

  11. Remarks on managerial errors and public participation

    International Nuclear Information System (INIS)

    Hilberry, N.

    1978-01-01

    The failure of the Salt Vault project at Lyons was only a managerial error, as were the leaks in the Hanford tanks. Administrative and managerial decision-making needs to be distinguished. Despite claims to special welfare for the public welfare, no segment of the public, such as environmentalist groups, should be permitted to exercise greater (or lesser) political pressure than any other segment. The US NRC Commissioners should be the personification of the public for all operational purposes

  12. Clinical Neuropathology practice news 1-2014: Pyrosequencing meets clinical and analytical performance criteria for routine testing of MGMT promoter methylation status in glioblastoma

    Science.gov (United States)

    Preusser, Matthias; Berghoff, Anna S.; Manzl, Claudia; Filipits, Martin; Weinhäusel, Andreas; Pulverer, Walter; Dieckmann, Karin; Widhalm, Georg; Wöhrer, Adelheid; Knosp, Engelbert; Marosi, Christine; Hainfellner, Johannes A.

    2014-01-01

    Testing of the MGMT promoter methylation status in glioblastoma is relevant for clinical decision making and research applications. Two recent and independent phase III therapy trials confirmed a prognostic and predictive value of the MGMT promoter methylation status in elderly glioblastoma patients. Several methods for MGMT promoter methylation testing have been proposed, but seem to be of limited test reliability. Therefore, and also due to feasibility reasons, translation of MGMT methylation testing into routine use has been protracted so far. Pyrosequencing after prior DNA bisulfite modification has emerged as a reliable, accurate, fast and easy-to-use method for MGMT promoter methylation testing in tumor tissues (including formalin-fixed and paraffin-embedded samples). We performed an intra- and inter-laboratory ring trial which demonstrates a high analytical performance of this technique. Thus, pyrosequencing-based assessment of MGMT promoter methylation status in glioblastoma meets the criteria of high analytical test performance and can be recommended for clinical application, provided that strict quality control is performed. Our article summarizes clinical indications, practical instructions and open issues for MGMT promoter methylation testing in glioblastoma using pyrosequencing. PMID:24359605

  13. Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.

    Science.gov (United States)

    Felsberg, Jörg; Thon, Niklas; Eigenbrod, Sabina; Hentschel, Bettina; Sabel, Michael C; Westphal, Manfred; Schackert, Gabriele; Kreth, Friedrich Wilhelm; Pietsch, Torsten; Löffler, Markus; Weller, Michael; Reifenberger, Guido; Tonn, Jörg C

    2011-08-01

    Epigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methylation status and the expression of MGMT and the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 in pairs of primary and recurrent glioblastomas of 80 patients, including 64 patients treated with radiotherapy and TMZ after the first operation. Among the primary tumors, the MGMT promoter was methylated in 31 patients and unmethylated in 49 patients. In 71 patients (89%), the MGMT promoter methylation status of the primary tumor was retained at recurrence. MGMT promoter methylation, but not MGMT protein expression, was associated with longer progression-free survival, overall survival and postrecurrence survival (PRS). Moreover, PRS was increased under salvage chemotherapy. Investigation of primary and recurrent glioblastomas of 43 patients did not identify promoter methylation in any of the four MMR genes. However, recurrent glioblastomas demonstrated significantly lower MSH2, MSH6 and PMS2 protein expression as detected by immunohistochemistry. In conclusion, reduced expression of MMR proteins, but not changes in MGMT promoter methylation, is characteristic of glioblastomas recurring after the current standards of care. Copyright © 2011 UICC.

  14. Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma

    International Nuclear Information System (INIS)

    Santos, Juliana Carvalho; Bastos, André Uchimura; Cerutti, Janete Maria; Ribeiro, Marcelo Lima

    2013-01-01

    Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated with mutations in genes such as BRAF, RAS and IDH1 in colon and brain tumours. Little is known about the methylation status of MLH1 and MGMT in thyroid tumours and its association with MSI and mutational status. In a series of 96 thyroid tumours whose mutational profiles of BRAF, IDH1 and NRAS mutations and RET/PTC were previously determined, we investigated MLH1 and MGMT expression and methylation status by qPCR and methylation-specific PCR after bisulphite treatment, respectively. MSI was determined by PCR using seven standard microsatellite markers. Samples with point mutations (BRAF, IDH1 and NRAS) show a decrease in MLH1 expression when compared to negative samples. Additionally, malignant lesions show a higher MSI pattern than benign lesions. The MSI phenotype was also associated with down-regulation of MLH1. The results of this study allow us to conclude that low expression of MLH1 is associated with BRAF V600E mutations, RET/PTC rearrangements and transitions (IDH1 and NRAS) in patients with thyroid carcinoma. In addition, a significant relationship between MSI status and histological subtypes was found

  15. The effects of tumor treating fields and temozolomide in MGMT expressing and non-expressing patient-derived glioblastoma cells.

    Science.gov (United States)

    Clark, Paul A; Gaal, Jordan T; Strebe, Joslyn K; Pasch, Cheri A; Deming, Dustin A; Kuo, John S; Robins, H Ian

    2017-02-01

    A recent Phase 3 study of newly diagnosed glioblastoma (GBM) demonstrated the addition of tumor treating fields (TTFields) to temozolomide (TMZ) after combined radiation/TMZ significantly increased survival and progression free survival. Preliminary data suggested benefit with both methylated and unmethylated O-6-methylguanine-DNA methyl-transferase (MGMT) promoter status. To date, however, there have been no studies to address the potential interactions of TTFields and TMZ. Thus, the effects of TTFields and TMZ were studied in vitro using patient-derived GBM stem-like cells (GSCs) including MGMT expressing (TMZ resistant: 12.1 and 22GSC) and non-MGMT expressing (TMZ sensitive: 33 and 114GSC) lines. Dose-response curves were constructed using cell proliferation and sphere-forming assays. Results demonstrated a ⩾10-fold increase in TMZ resistance of MGMT-expressing (12.1GSCs: IC 50 =160μM; 22GSCs: IC 50 =44μM) compared to MGMT non-expressing (33GSCs: IC 50 =1.5μM; 114GSCs: IC 50 =5.2μM) lines. TTFields inhibited 12.1 GSC proliferation at all tested doses (50-500kHz) with an optimal frequency of 200kHz. At 200kHz, TTFields inhibited proliferation and tumor sphere formation of both MGMT GSC subtypes at comparable levels (12.1GSC: 74±2.9% and 38±3.2%, respectively; 22GSC: 61±11% and 38±2.6%, respectively; 33GSC: 56±9.5% and 60±7.1%, respectively; 114 GSC: 79±3.5% and 41±4.3%, respectively). In combination, TTFields (200kHz) and TMZ showed an additive anti-neoplastic effect with equal efficacy for TTFields in both cell types (i.e., ± MGMT expression) with no effect on TMZ resistance. This is the first demonstration of the effects of TTFields on cancer stem cells. The expansion of such studies may have clinical implications. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Three perspectives on physical therapist managerial work.

    Science.gov (United States)

    Schafer, D Sue

    2002-03-01

    The nature of managerial work in the commercial sector has not been studied since the 1970s, and little is known about the work of managers in the health care sector. In this study, the perceived importance of managerial role and skill categories among 3 groups of physical therapists were studied to better understand the work priorities of physical therapist managers. Two groups of subjects were physical therapist managers in hospitals or private practices. A third group consisted of faculty members in professional physical therapist education programs. Respondents (n=343) rated the importance of 75 managerial activities. Responses related to 16 predetermined work categories were placed in rank order by group. A multivariate analysis of variance (MANOVA) was used to identify differences among groups. All groups identified communication, financial control, entrepreneur, resource allocator, and leader as the 5 most important categories and rated technical expert and figurehead as least important. The MANOVA showed differences between faculty members and private practice managers in 15 work categories, between hospital-based managers and private practice managers in 9 categories, and between faculty members and hospital-based managers in 8 categories. Work setting appears to have an impact on level of importance placed on managerial work categories. The strongest candidates for "universal" physical therapist managerial work categories were communication, financial control, and resource allocator.

  17. DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide.

    Directory of Open Access Journals (Sweden)

    Amandine Etcheverry

    Full Text Available Consistently reported prognostic factors for glioblastoma (GBM are age, extent of surgery, performance status, IDH1 mutational status, and MGMT promoter methylation status. We aimed to integrate biological and clinical prognostic factors into a nomogram intended to predict the survival time of an individual GBM patient treated with a standard regimen. In a previous study we showed that the methylation status of the DGKI promoter identified patients with MGMT-methylated tumors that responded poorly to the standard regimen. We further evaluated the potential prognostic value of DGKI methylation status.399 patients with newly diagnosed GBM and treated with a standard regimen were retrospectively included in this study. Survival modelling was performed on two patient populations: intention-to-treat population of all included patients (population 1 and MGMT-methylated patients (population 2. Cox proportional hazard models were fitted to identify the main prognostic factors. A nomogram was developed for population 1. The prognostic value of DGKI promoter methylation status was evaluated on population 1 and population 2.The nomogram-based stratification of the cohort identified two risk groups (high/low with significantly different median survival. We validated the prognostic value of DGKI methylation status for MGMT-methylated patients. We also demonstrated that the DGKI methylation status identified 22% of poorly responding patients in the low-risk group defined by the nomogram.Our results improve the conventional MGMT stratification of GBM patients receiving standard treatment. These results could help the interpretation of published or ongoing clinical trial outcomes and refine patient recruitment in the future.

  18. DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide.

    Science.gov (United States)

    Etcheverry, Amandine; Aubry, Marc; Idbaih, Ahmed; Vauleon, Elodie; Marie, Yannick; Menei, Philippe; Boniface, Rachel; Figarella-Branger, Dominique; Karayan-Tapon, Lucie; Quillien, Veronique; Sanson, Marc; de Tayrac, Marie; Delattre, Jean-Yves; Mosser, Jean

    2014-01-01

    Consistently reported prognostic factors for glioblastoma (GBM) are age, extent of surgery, performance status, IDH1 mutational status, and MGMT promoter methylation status. We aimed to integrate biological and clinical prognostic factors into a nomogram intended to predict the survival time of an individual GBM patient treated with a standard regimen. In a previous study we showed that the methylation status of the DGKI promoter identified patients with MGMT-methylated tumors that responded poorly to the standard regimen. We further evaluated the potential prognostic value of DGKI methylation status. 399 patients with newly diagnosed GBM and treated with a standard regimen were retrospectively included in this study. Survival modelling was performed on two patient populations: intention-to-treat population of all included patients (population 1) and MGMT-methylated patients (population 2). Cox proportional hazard models were fitted to identify the main prognostic factors. A nomogram was developed for population 1. The prognostic value of DGKI promoter methylation status was evaluated on population 1 and population 2. The nomogram-based stratification of the cohort identified two risk groups (high/low) with significantly different median survival. We validated the prognostic value of DGKI methylation status for MGMT-methylated patients. We also demonstrated that the DGKI methylation status identified 22% of poorly responding patients in the low-risk group defined by the nomogram. Our results improve the conventional MGMT stratification of GBM patients receiving standard treatment. These results could help the interpretation of published or ongoing clinical trial outcomes and refine patient recruitment in the future.

  19. Personalitate şi nivel managerial

    Directory of Open Access Journals (Sweden)

    Andrei Ion

    2012-01-01

    Full Text Available This study investigates the relationship between personality traits and managerial level. Personality traits were assessed by using the Romanian version of the California Psychological Inventory – 260 (Gough, 2002. The inclusion criteria in the three managerial groups (low level management, middle level management and high level management were the number of subordinates and the reported distance from the CEO. Data were collected from the managers at a few companies from the fast moving consumer goods and telecom industry. Results indicated that some personality traits varied significantly across the three groups of managers. Moreover the scores on three scales appear to vary significantly across males and females samples.

  20. Power forward curves: a managerial perspective

    International Nuclear Information System (INIS)

    Nagarajan, Shankar

    1999-01-01

    This chapter concentrates on managerial application of power forward curves, and examines the determinants of electricity prices such as transmission constraints, its inability to be stored in a conventional way, its seasonality and weather dependence, the generation stack, and the swing risk. The electricity forward curve, classical arbitrage, constructing a forward curve, volatilities, and electricity forward curve models such as the jump-diffusion model, the mean-reverting heteroscedastic volatility model, and an econometric model of forward prices are examined. A managerial perspective of the applications of the forward curve is presented covering plant valuation, capital budgeting, performance measurement, product pricing and structuring, asset optimisation, valuation of transmission options, and risk management

  1. Scottish Education and the New Managerialism.

    Science.gov (United States)

    Fairley, John; Paterson, Lindsay

    1995-01-01

    Argues that the "new managerialism" approach to educational management in Scotland, with its emphasis on performance monitoring, diverts attention away from the core concerns of educational delivery and incurs significant bureaucratic costs. An alternative model, which is based on collegiality and democracy, focuses on professionalism,…

  2. Gendered Learning Environments in Managerial Work

    Science.gov (United States)

    Gustavsson, Maria; Eriksson, Anna Fogelberg

    2010-01-01

    The aim is to investigate female and male managers' learning environments with particular focus on their opportunities for and barriers to learning and career development in the managerial work of a male-dominated industrial company. In the case study 42 managers, 15 women and 27 men in the company were interviewed. The findings demonstrate that…

  3. Commandants' Managerial Capacity and Workers Productivity in ...

    African Journals Online (AJOL)

    The purpose of this study is to evaluate the commandant's managerial capacity as if relates to workers productivity with a view to determining whether their calling to the education terrain has been justified and to correct certain areas in need of improvement in the Nigeria Police Education set up. In doing this, the study took ...

  4. Exploring Methods in Managerial and Organizational Cognition

    DEFF Research Database (Denmark)

    Hodgkinson, Gerard P.; Sund, Kristian J.; Galavan, Robert

    2017-01-01

    This book comprises the second volume in the recently launched New Horizons in Managerial and Organizational Cognition book series. Volume 1 (Sund, Galavan, & Huff, 2016), addressed the topic of strategic uncertainty. This second volume comprises a collection of contributions that variously report...

  5. Option Strike Price and Managerial Investment Decisions

    Institute of Scientific and Technical Information of China (English)

    刘鸿雁; 张维

    2003-01-01

    The manager′s investment decisions is modeled when the manager is risk-averse and has stock options as compensation. It is found that the strike price of options is crucial to the investment incentives of managers, and that the correct value, or interval of values, of managerial stock option strike price can bring stockholder and manager interests in agreement.

  6. Internal Management and Perceived Managerial Trustworthiness

    DEFF Research Database (Denmark)

    Pedersen, Mogens Jin; Stritch, Justin Michael

    2018-01-01

    What is the effect of internal public management on individuals’ perceptions of managerial trustworthiness (MTW)? MTW is associated with a range of positive organizational outcomes, but research examining how a public manager might affect employees’ perception of MTW is sparse. This article compl...

  7. Managerial Effectiveness: Impact of Emotional Intellegence and ...

    African Journals Online (AJOL)

    organizations in Nigeria. The descriptive survey research method was adopted for the study. Instruments used for data collection in this study are: Emotional Intelligence Scale, Work-Family Role Conflict Scale and. Managerial Effectiveness Scale. Linear Regression Analysis was used to test hypotheses that were generated ...

  8. Leadership and managerial capacity strengthening for quality ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Success in the implementation of maternal and newborn health interventions at the country level has been generally attributed to three main interlinked factors: leadership and management, resources, and end-user-related factors. Leadership and managerial capacities are critical for transformational change and ...

  9. O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

    Science.gov (United States)

    Bobola, Michael S.; Alnoor, Mohammad; Chen, John Y.-S.; Kolstoe, Douglas D.; Silbergeld, Daniel L.; Rostomily, Robert C.; Blank, A.; Chamberlain, Marc C.; Silber, John R.

    2014-01-01

    Background CpG methylation in the O6-methylguanine-DNA methyltransferase (MGMT) promoter is associated with better outcome following alkylating agent chemotherapy in glioblastoma (GBM) and anaplastic glioma (AG). To what extent improved response reflects low or absent MGMT activity in glioma tissue has not been unequivocally assessed. This information is central to developing anti-resistance therapies. Methods We examined the relationship of MGMT activity in 91 GBMs and 84 AGs with progression-free survival (PFS) following alkylator therapy and with promoter methylation status determined by methylation-specific PCR (MSP). Results Cox regression analysis revealed that GBMs with high activity had a significantly greater risk for progression in dichotomous (P ≤ 0.001) and continuous (P ≤ 0.003) models, an association observed for different alkylator regimens, including concurrent chemo-radiation with temozolomide. Analysis of MGMT promoter methylation status in 47 of the GBMs revealed that methylated tumors had significantly lower activity (P ≤ 0.005) and longer PFS (P ≤ 0.036) compared to unmethylated tumors, despite overlapping activities. PFS was also significantly greater in methylated vs. unmethylated GBMs with comparable activity (P ≤ 0.005), and among unmethylated tumors with less than median activity (P ≤ 0.026), suggesting that mechanisms in addition to MGMT promote alkylator resistance. Similar associations of MGMT activity with PFS and promoter methylation status were observed for AGs. Conclusions Our results provide strong support for the hypotheses that MGMT activity promotes alkylator resistance and reflects promoter methylation status in malignant gliomas. General significance MGMT activity is an attractive target for anti-resistance therapy regardless of methylation status. PMID:25558448

  10. Using a Common Experience to Teach Introductory Managerial Accounting

    Science.gov (United States)

    King, Gail Hoover; McConnell, Cheryl

    2010-01-01

    Teaching introductory accounting courses can be both challenging and rewarding. In introductory financial and managerial accounting, students struggle with the unfamiliar terminology and concepts. However, managerial accounting offers distinct challenges in that managerial accounting reports used for decision-making are not publically available,…

  11. Double-labelling immunohistochemistry for MGMT and a “cocktail” of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours

    OpenAIRE

    Burke, Elinor; Grobler, Mariana; Elderfield, Kay; Bond, Frances; Crocker, Matthew; Taylor, Rohan; Bridges, Leslie R

    2013-01-01

    Background Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT an...

  12. THE NEED FOR MANAGERIAL ACCOUNTING SYSTEMS

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    Flavius-Andrei GUINEA

    2016-12-01

    Full Text Available The implementation of a managerial accounting system represents a genuine initiative for implementing change, this involving the need for change, a vision of change and strategy, and last, but not least, innovation stimulation. In the last decades, the implementation of such a system translated into a broader reform, including the management system used. A management control system, once implemented, tends to attract the manifestation of creative accounting phenomena, especially in times of crisis. Taking these into consideration, the article aims to highlight the importance of the implementation of a modern managerial accounting system in the Romanian firms, as well as to analyse the potential consequences of this process, from the author’s point of view.

  13. MANAGERIAL ACCOUNTING SYSTEM: UTILITY, PRACTICE, MANIPULATION, NORMALIZATION

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    Flavius-Andrei GUINEA

    2017-05-01

    Full Text Available Economic entities accuse current managerial accounting instruments due to their used indicators, their post operativeness, and their lack of necessary adjustments, short-term target, information handling and decisions taken for various reasons, except the efficiency one. In order to manage a more and more complex organization, located in an uncertain environment, managers require a permanent, real-time, information system. There is no longer sufficient the simple retrospective measurement of results, as there should be provided those instruments that support the decision making process throughout the strategic and operational processes. The implementation of a managerial accounting tool will always interact with the human behavioural dimension. In the initial stage, the actors of an organization will initially manifest reactions of difficult acceptance or even rejection. Each of them will adopt that behaviour which ensures the maximization of its own goals, even if these are, or not, convergent with the organizational objectives.

  14. Gendered learning environments in managerial work

    OpenAIRE

    Gustavsson, Maria; Fogelberg Eriksson, Anna

    2010-01-01

    The aim is to investigate female and male managers’ learning environments with particular focus on their opportunities for and barriers to learning and career development in the managerial work of a male-dominated industrial company. In the case study 42 managers, 15 women and 27 men in the company were interviewed. The findings demonstrate that the male managers were provided with significantly richer opportunities to participate in activities conducive to learning and career development tha...

  15. Stock Option Compensation and Managerial Turnover

    OpenAIRE

    Raluca Georgiana NASTASESCU

    2009-01-01

    This study examines the association between managerial turnover and equity-based compensation. I investigate whether stock options act to bond executives to their firms and whether retention of managers is a motivation of companies in designing CEO incentive contracts. The results show that stock options do negatively influence the probability of a CEO leaving the company. The monetary cost of losing the value of equity-based compensation package keeps the manager with his company. I also fin...

  16. Managerial Roles and Functions in Negotiation Process

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    Andrzej Kozina

    2014-06-01

    Full Text Available The paper is focused on negotiation processes performed in a company and presents author’s concept of the description of the roles and functions accomplished by managers within those processes and being of significant importance from the point of view of negotiations’ outcomes. Such a concept aims at providing the analysis and conducting of business negotiations with effective support. Firstly (following introduction, the concept, types, and comprehensive model of such negotiations is presented as a useful methodological framework for specifying managerial roles and functions. Secondly, some classic concepts of those roles are reviewed, drawing special attention to the ones that concern negotiation process. Thirdly, general managerial functions within that process are described. Fourthly, those functions are precised by relating them to typical hierarchical levels. Fifthly, peculiar managerial functions within negotiating team are discussed. Finally, specific issue of the role of manager as a mediator is addressed. Summing up the paper, the crucial areas for subsequent research were pointed out. In order to elaborate the presented concept the author carried out the comparative study of negotiation literature as well as developed his original ideas.

  17. Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients.

    Science.gov (United States)

    Li, Xia; Wang, Yibaina; Zhang, Zuoming; Yao, Xiaoping; Ge, Jie; Zhao, Yashuang

    2013-11-01

    CpG island methylation in the promoter regions of the DNA mismatch repair gene mutator L homologue 1 ( MLH1 ) and DNA repair gene O 6 -methylguanine-DNA methyltransferase ( MGMT ) genes has been shown to occur in the leukocytes of peripheral blood and colorectal tissue. However, it is unclear whether the methylation levels in the blood leukocytes and colorectal tissue are correlated. The present study analyzed and compared the levels of MGMT and MLH1 gene methylation in the leukocytes of peripheral blood and colorectal tissues obtained from patients with colorectal cancer (CRC). The methylation levels of MGMT and MLH1 were examined using methylation-sensitive high-resolution melting (MS-HRM) analysis. A total of 44 patients with CRC were selected based on the MLH1 and MGMT gene methylation levels in the leukocytes of the peripheral blood. Corresponding colorectal tumor and normal tissues were obtained from each patient and the DNA methylation levels were determined. The correlation coefficients were evaluated using Spearman's rank test. Agreement was determined by generalized κ-statistics. Spearman's rank correlation coefficients (r) for the methylation levels of the MGMT and MLH1 genes in the leukocytes of the peripheral blood and normal colorectal tissue were 0.475 and 0.362, respectively (P=0.001 and 0.016, respectively). The agreement of the MGMT and MLH1 gene methylation levels in the leukocytes of the peripheral blood and normal colorectal tissue were graded as fair and poor (κ=0.299 and 0.126, respectively). The methylation levels of MGMT and MLH1 were moderately and weakly correlated between the patient-matched leukocytes and the normal colorectal tissue, respectively. Blood-derived DNA methylation measurements may not always represent the levels of normal colorectal tissue methylation.

  18. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma.

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    Fumiharu Ohka

    Full Text Available Gliomas are the most frequently occurring primary brain tumor in the central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4 have a dismal prognosis despite the use of the alkylating agent, temozolomide (TMZ, and even low grade gliomas (LGGs, WHO grade 2 eventually transform to malignant secondary GBMs. Although GBM patients benefit from promoter hypermethylation of the O(6-methylguanine-DNA methyltransferase (MGMT that is the main determinant of resistance to TMZ, recent studies suggested that MGMT promoter methylation is of prognostic as well as predictive significance for the efficacy of TMZ. Glioma-CpG island methylator phenotype (G-CIMP in the global genome was shown to be a significant predictor of improved survival in patients with GBM. Collectively, we hypothesized that MGMT promoter methylation might reflect global DNA methylation. Additionally in LGGs, the significance of MGMT promoter methylation is still undetermined. In the current study, we aimed to determine the correlation between clinical, genetic, and epigenetic profiles including LINE-1 and different cancer-related genes and the clinical outcome in newly diagnosed 57 LGG and 54 GBM patients. Here, we demonstrated that (1 IDH1/2 mutation is closely correlated with MGMT promoter methylation and 1p/19q codeletion in LGGs, (2 LINE-1 methylation levels in primary and secondary GBMs are lower than those in LGGs and normal brain tissues, (3 LINE-1 methylation is proportional to MGMT promoter methylation in gliomas, and (4 higher LINE-1 methylation is a favorable prognostic factor in primary GBMs, even compared to MGMT promoter methylation. As a global DNA methylation marker, LINE-1 may be a promising marker in gliomas.

  19. Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.

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    Arne Christians

    Full Text Available Hypermethylation in the promoter region of the MGMT gene encoding the DNA repair protein O(6-methylguanine-DNA methyltransferase is among the most important prognostic factors for patients with glioblastoma and predicts response to treatment with alkylating agents like temozolomide. Hence, the MGMT status is widely determined in most clinical trials and frequently requested in routine diagnostics of glioblastoma. Since various different techniques are available for MGMT promoter methylation analysis, a generally accepted consensus as to the most suitable diagnostic method remains an unmet need. Here, we assessed methylation-specific polymerase chain reaction (MSP as a qualitative and semi-quantitative method, pyrosequencing (PSQ as a quantitative method, and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA as a semi-quantitative method in a series of 35 formalin-fixed, paraffin-embedded glioblastoma tissues derived from patients treated in a prospective clinical phase II trial that tested up-front chemoradiotherapy with dose-intensified temozolomide (UKT-05. Our goal was to determine which of these three diagnostic methods provides the most accurate prediction of progression-free survival (PFS. The MGMT promoter methylation status was assessable by each method in almost all cases (n = 33/35 for MSP; n = 35/35 for PSQ; n = 34/35 for MS-MLPA. We were able to calculate significant cut-points for the continuous methylation signals at each CpG site analysed by PSQ (range, 11.5 to 44.9% and at one CpG site assessed by MS-MLPA (3.6% indicating that a dichotomisation of continuous methylation data as a prerequisite for comparative survival analyses is feasible. Our results show that, unlike MS-MLPA, MSP and PSQ provide a significant improvement of predicting PFS compared with established clinical prognostic factors alone (likelihood ratio tests: p<0.001. Conclusively, taking into consideration prognostic value

  20. MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells

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    Lee YY

    2018-04-01

    Full Text Available Yi-Yen Lee,1,2,* Aliaksandr A Yarmishyn,3,4,* Mong-Lien Wang,3,4 Hsiao-Yun Chen,4,5 Shih-Hwa Chiou,3–5 Yi-Ping Yang,4,5 Chun-Fu Lin,1,2 Pin-I Huang,2,6 Yi-Wei Chen,2,6 Hsin-I Ma,7 Ming-Teh Chen1,2 1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 2Faculty of Medicine, National Yang-Ming University, 3Institute of Pharmacology, National Yang-Ming University, 4Department of Medical Research, Taipei Veterans General Hospital, 5Institute of Clinical Medicine, National Yang Ming University, 6Cancer Center, Radiation Oncology Division, Taipei Veterans General Hospital, 7Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan *These authors contributed equally to this work Background: Glioblastoma multiforme (GBM is the most malignant brain tumor, and there is no effective treatment strategy. Patients with GBM have a median overall survival of only 14.6 months. Current treatment consists of safe and maximal surgical excision, followed by concurrent chemoradiotherapy and maintenance chemotherapy. There are several obstacles that hinder the effectiveness of this aggressive treatment. Temozolomide (TMZ is an oral alkylating drug that acts through alkylating the O6 position of guanine in DNA that leads to cell death. However, the expression and enzymatic activity of the DNA repair protein MGMT limits the therapeutic benefit from treatment with TMZ. MGMT reduces the efficacy of alkylating drugs by removing the methyl or alkyl group from damaged O6-methylguanine. Expression levels of MGMT play an important role in the outcome of GBM patients. miRNAs are a group of small regulatory RNAs that control target gene expression by binding to mRNAs. miR-142-3p has been found to be an important factor in the development and maintenance of the oncogenic state. Results: In this study, we sought to investigate whether miR-142-3p can regulate MGMT gene expression in GBM cells

  1. Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

    Science.gov (United States)

    Sartore-Bianchi, Andrea; Pietrantonio, Filippo; Amatu, Alessio; Milione, Massimo; Cassingena, Andrea; Ghezzi, Silvia; Caporale, Marta; Berenato, Rosa; Falcomatà, Chiara; Pellegrinelli, Alessio; Bardelli, Alberto; Nichelatti, Michele; Tosi, Federica; De Braud, Filippo; Di Nicolantonio, Federica; Barault, Ludovic; Siena, Salvatore

    2017-01-01

    O(6)-methylguanine-DNA-methyltransferase (MGMT) is a repair protein, and its deficiency makes tumours more susceptible to the cytotoxic effect of alkylating agents. Five clinical trials with temozolomide or dacarbazine have been performed in metastatic colorectal cancer (mCRC) with selection based on methyl-specific PCR (MSP) testing with modest results. We hypothesised that mitigated results are consequences of unspecific patient selection and that alternative methodologies for MGMT testing such as immunohistochemistry (IHC) and digital polymerase chain reaction (PCR) could enhance patient enrolment. Formalin-fixed paraffin embedded archival tumour tissue samples from four phase II studies of temozolomide or dacarbazine in MGMT MSP-positive mCRCs were analysed by IHC for MGMT protein expression and by methyl-BEAMing (MB) for percentage of promoter methylation. Pooled data were then retrospectively analysed according to objective response rate, progression-free survival (PFS) and overall survival (OS). One hundred and five patients were included in the study. Twelve had achieved partial response (PR) (11.4%), 24 stable disease (SD; 22.9%) and 69 progressive disease (PD; 65.7%). Patients with PR/SD had lower IHC scores and higher MB levels than those with PD. MGMT expression by IHC was negatively and MB levels positively associated with PFS (p alkylating agents. Their combination could enhance patient selection in this setting. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. A study to determine important barriers in using managerial accounting

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    Rahmatollah Mohammadipour

    2012-09-01

    Full Text Available Managerial accounting plays an important role for making prompt and efficient decisions to reduce troubles in the market. However, there are many circumstances where management team cannot make appropriate, fast and reliable managerial decisions. In this paper, we present a survey in cement industry and look to find out important factors as major barriers of managerial accounting implementation. The proposed model of this paper designs and distributes questionnaire among management teams who work for cement industry in Iran. The results of the survey indicate that lack of familiarity of managers with managerial accounting techniques, existence of unprofessional people in financial and accounting affairs and lack of having globally acceptable standards are major barriers in this industry for implementation of managerial accounting skills. However, our survey does not find any relationship between market turbulence and efficiency and implementation of managerial accounting skills.

  3. Managerial share ownership, firm performance and dividends : Australian evidence

    OpenAIRE

    Khan, Arifur Rahman

    2017-01-01

    This thesis examines the relationship between managerial share ownership and firm performance as well as the relationship between managerial share ownership and dividends in Australia. Agency theory, more specifically two alternative theories – incentive alignment and managerial entrenchment theory – provides the theoretical framework that underpins this thesis. The three empirical studies in this thesis examine the top 300 Australian listed companies for the period 2000 to 2006 and the metho...

  4. Transformation of University Organizations:Leadership and Managerial Implications

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    Cemil ULUKAN

    2005-10-01

    Full Text Available Transformation of University Organizations:Leadership and Managerial Implications Cemil ULUKAN, Ph.D Anadolu UniversityOpen Education Faculty Eskisehir-TURKEYABSTRACT Technology and globalization are forcing higher education institutions to transform themselves. This paper aims to contribute to a better understanding the leadership and managerial implications of recent developments for higher education. Reviewing unique characteristics and the fundamental changes shaping higher education, the paper examines the need for organizational transformation and the major managerial implications.

  5. MANAGERIAL AND COST ACCOUNTING PRACTICES - A ROMANIAN OVERVIEW

    OpenAIRE

    CARDOS ILDIKO REKA; PETE STEFAN

    2011-01-01

    Research theme - Globalization and technological changes generates complexity both in the business environment and the accounting systems. Under these conditions managerial accounting needs to learn new practices in order to become an active consultant of management. Objectives - The main objective of this paper is to present how managerial accounting changed over the years in Romania. We intend to present how the managerial accounting system is implemented within Romanian organizations, to r...

  6. MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

    NARCIS (Netherlands)

    P. Bady (Pierre); D. Sciuscio (Davide); A.C. Diserens; J. Bloch (Jocelyne); M.J. van den Bent (Martin); C. Marosi (Christine); P-Y. Dietrich (Pierre Yves); M. Weller (Michael); L. Mariani (Luigi); F.L. Heppner (Frank ); D.R. Mcdonald (David ); D. Lacombe (Denis); R. Stupp (Roger); M. Delorenzi (Mauro); M.E. Hegi (Monika)

    2012-01-01

    textabstractThe methylation status of the O6-methylguanine- DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of

  7. MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status.

    Science.gov (United States)

    Bady, Pierre; Sciuscio, Davide; Diserens, Annie-Claire; Bloch, Jocelyne; van den Bent, Martin J; Marosi, Christine; Dietrich, Pierre-Yves; Weller, Michael; Mariani, Luigi; Heppner, Frank L; Mcdonald, David R; Lacombe, Denis; Stupp, Roger; Delorenzi, Mauro; Hegi, Monika E

    2012-10-01

    The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and epigenetic features of this intriguingly distinct behavior requires accurate MGMT classification to assess high throughput molecular databases. Promoter methylation-mediated gene silencing is strongly dependent on the location of the methylated CpGs, complicating classification. Using the HumanMethylation450 (HM-450K) BeadChip interrogating 176 CpGs annotated for the MGMT gene, with 14 located in the promoter, two distinct regions in the CpG island of the promoter were identified with high importance for gene silencing and outcome prediction. A logistic regression model (MGMT-STP27) comprising probes cg12434587 [corrected] and cg12981137 provided good classification properties and prognostic value (kappa = 0.85; log-rank p CIMP) positive tumors was found in glioblastomas from The Cancer Genome Atlas than in low grade and anaplastic glioma cohorts, while in CIMP-negative gliomas MGMT was classified as methylated in approximately 50 % regardless of tumor grade. The proposed MGMT-STP27 prediction model allows mining of datasets derived on the HM-450K or HM-27K BeadChip to explore effects of distinct epigenetic context of MGMT methylation suspected to modulate treatment resistance in different tumor types.

  8. MANAGERIAL AND COST ACCOUNTING PRACTICES - A ROMANIAN OVERVIEW

    Directory of Open Access Journals (Sweden)

    CARDOS ILDIKO REKA

    2011-12-01

    Full Text Available Research theme Globalization and technological changes generates complexity both in the business environment and the accounting systems. Under these conditions managerial accounting needs to learn new practices in order to become an active consultant of management. Objectives: The main objective of this paper is to present how managerial accounting changed over the years in Romania. We intend to present how the managerial accounting system is implemented within Romanian organizations, to report the level of adoption of traditional practices, tools and techniques, to identify to what extent contemporary managerial accounting practices are implemented and used, and finally to identify whether managerial accounting information is useful for business decisions. Prior works: Over the years researchers from all over the world were interested in managerial accounting changes and innovations, in managerial accounting practices, tools and techniques adopted by organizations. On international level the study made by Pavlatos and Paggios (2009 and on national level the study made by Jinga et al (2010 represents the starting point of our study. Both research team conducted a study on managerial accounting practices and the utility of managerial accounting information and found out that managerial accounting information is useful for managers in the decision making process but traditional practices, tools and techniques are used to 'produce' this type of information. Design/methodology : An empirical study was conducted in 2010 within Romanian accounting professionals. A questionnaire was sent to a number of 1871 professionals members of The Body of Expert and Licensed Accountants of Romania regarding managerial accounting practices, tools and techniques adopted and implemented. Data obtained was processed and analyzed with the help of descriptive statistics. Results/findings - Romanian professionals consider that managerial accounting information is useful

  9. Managerial Challenges in Investment Market Research

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    Daniel Manaţe

    2012-12-01

    Full Text Available Since1860 the investment community beneficiated by the first structured approach regarding the ocean of data which every potential money supplier was flooded with. It was Henry Poor who leaded the new investment way and, later, was followed by noble successors like John Moody, Benjamin Graham, David Dodd or John Burr Williams. They founded what today is called the fundamental analysis. The continuous increase of the turbulence and complexity of the environment confronting global, regional or local investors enhanced the need for a better managerial approach within the investment process. This was John Murphy’s mastermind work of synthesis, the intermarket analysis. The essence of this managerial approach is to profit the most from the global market relationships between equities market, forex market, commodities market and credit market. Studying the interaction among these markets and deciding accordingly the in and outs positions on different financial instruments paid far better than strategies such as the naive „buy and hold” or the manipulative „buy on rumours - sell on news”.

  10. ADAPTATION MODEL FOR REDUCING THE MANAGERIAL STRESS

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    VIOLETA GLIGOROVSKI

    2017-12-01

    Full Text Available Changes are an inseparable component of the company's life cycle and they can contribute to its essential growth in the future. The purpose of this paper is to explain managerial stress caused by implementation of changes and creating an adaptation model to decrease managerial stress. How much the manager will successfully lead the project for implementation of a change and how much they will manage to amortize stress among employees, mostly depends on their expertise, knowledge and skills to accurately and comprehensively inform and integrate the employees in the overall process. The adaptation model is actually a new approach and recommendation for managers for dealing with stress when the changes are implemented. Methodology. For this purpose, the data presented, in fact, were collected through a questionnaire that was submitted to 61 respondents/ managers. The data were measured using the Likert scale from 1 to 7. Namely, with the help of the Likert scale, quantification of stress was made in relation to the various variables that were identified as the most important for the researched issues. An adaption model (new approach for amortizing changes was created using the DIA Diagram application, to show the relations between manager and the relevant amortization approaches.

  11. Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population.

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    Rupal Sinha

    Full Text Available Colorectal cancer (CRC development involves underlying modifications at genetic/epigenetic level. This study evaluated the role of Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation together/independently in sporadic CRC in Indian population and correlation with clinicopathological variables of the disease.One hundred and twenty four consecutive surgically resected tissues (62 tumor and equal number of normal adjacent controls of primary sporadic CRC were included and patient details including demographic characteristics, lifestyle/food or drinking habits, clinical and histopathological profiles were recorded. Polymerase chain reaction - Restriction fragment length polymorphism and direct sequencing for Kras gene mutation and Methylation Specific-PCR for RASSF1A, FHIT and MGMT genes was performed.Kras gene mutation at codon 12 & 13 and methylated RASSF1A, FHIT and MGMT gene was observed in 47%, 19%, 47%, 37% and 47% cases, respectively. Alcohol intake and smoking were significantly associated with presence of Kras mutation (codon 12 and MGMT methylation (p-value <0.049. Tumor stage and metastasis correlated with presence of mutant Kras codon 12 (p-values 0.018, 0.044 and methylated RASSF1A (p-values 0.034, 0.044, FHIT (p-values 0.001, 0.047 and MGMT (p-values 0.018, 0.044 genes. Combinatorial effect of gene mutation/methylation was also observed (p-value <0.025. Overall, tumor stage 3, moderately differentiated tumors, presence of lymphatic invasion and absence of metastasis was more frequently observed in tumors with mutated Kras and/or methylated RASSF1A, FHIT and MGMT genes.Synergistic interrelationship between these genes in sporadic CRC may be used as diagnostic/prognostic markers in assessing the overall pathological status of CRC.

  12. Double-labelling immunohistochemistry for MGMT and a “cocktail” of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours

    Science.gov (United States)

    2013-01-01

    Background Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA, a recognised molecular genetic technique which we applied as the gold-standard for the methylation status). Results Double-labelling immunohistochemistry for MGMT produced a visual separation of tumourous and non-tumourous elements on the same histological slide, making it quick and easy to determine whether tumour cell nuclei were MGMT-positive or MGMT-negative (and thereby infer the methylation status of the tumour). We found good agreement between observers (kappa 0.76) and within observer (kappa 0.84). Furthermore, double-labelling showed good specificity (80%), sensitivity (73.33%), positive predictive value (PPV, 83.33%) and negative predictive value (NPV, 68.75%) compared to MS-MLPA. Double-labelling was quicker and easier to assess than single-labelling and it outperformed quantitative computerised image analysis of MGMT single-labelling in terms of sensitivity, specificity, PPV and NPV. Conclusions Double-labelling immunohistochemistry for MGMT and a cocktail of non-tumourous elements provides a "one look" method for determining whether tumour cell nuclei are MGMT-positive or MGMT-negative. This can be used to infer the methylation status of the tumour. There is good observer agreement and good specificity, sensitivity, PPV and NPV compared to a molecular gold-standard. PMID:24252243

  13. Double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours.

    Science.gov (United States)

    Burke, Elinor; Grobler, Mariana; Elderfield, Kay; Bond, Frances; Crocker, Matthew; Taylor, Rohan; Bridges, Leslie R

    2013-06-10

    Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain tumours (30 glioblastomas and 10 oligodendroglial tumours) with our new technique, namely double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumour antigens (CD34, CD45 and CD68). We compared the results with single-labelling immunohistochemistry for MGMT and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA, a recognised molecular genetic technique which we applied as the gold-standard for the methylation status). Double-labelling immunohistochemistry for MGMT produced a visual separation of tumourous and non-tumourous elements on the same histological slide, making it quick and easy to determine whether tumour cell nuclei were MGMT-positive or MGMT-negative (and thereby infer the methylation status of the tumour). We found good agreement between observers (kappa 0.76) and within observer (kappa 0.84). Furthermore, double-labelling showed good specificity (80%), sensitivity (73.33%), positive predictive value (PPV, 83.33%) and negative predictive value (NPV, 68.75%) compared to MS-MLPA. Double-labelling was quicker and easier to assess than single-labelling and it outperformed quantitative computerised image analysis of MGMT single-labelling in terms of sensitivity, specificity, PPV and NPV. Double-labelling immunohistochemistry for MGMT and a cocktail of non-tumourous elements provides a "one look" method for determining whether tumour cell nuclei are MGMT-positive or MGMT-negative. This can be used to infer the methylation status of the tumour. There is good observer agreement and good specificity, sensitivity, PPV and NPV compared to a molecular gold-standard.

  14. Managerial Career Patterns: A Review of the Empirical Evidence

    Science.gov (United States)

    Vinkenburg, Claartje J.; Weber, Torsten

    2012-01-01

    Despite the ubiquitous presence of the term "career patterns" in the discourse about careers, the existing empirical evidence on (managerial) career patterns is rather limited. From this literature review of 33 published empirical studies of managerial and similar professional career patterns found in electronic bibliographic databases, it is…

  15. Managerial Career Patterns: A Review of the Empirical Evidence

    NARCIS (Netherlands)

    Vinkenburg, C.J.; Weber, T.

    2012-01-01

    Despite the ubiquitous presence of the term "career patterns" in the discourse about careers, the existing empirical evidence on (managerial) career patterns is rather limited. From this literature review of 33 published empirical studies of managerial and similar professional career patterns found

  16. Student Academic Performance in Undergraduate Managerial-Accounting Courses

    Science.gov (United States)

    Al-Twaijry, Abdulrahman Ali

    2010-01-01

    The author's purpose was to identify potential factors possibly affecting student performance in three sequential management-accounting courses: Managerial Accounting (MA), Cost Accounting (CA), and Advanced Managerial Accounting (AMA) within the Saudi Arabian context. The sample, which was used to test the developed hypotheses, included 312…

  17. The Managerial Roles of Academic Library Directors: The Mintzberg Model.

    Science.gov (United States)

    Moskowitz, Michael Ann

    1986-01-01

    A study based on a model developed by Henry Mintzberg examined the internal and external managerial roles of 126 New England college and university library directors. Survey results indicate that the 97 responding directors were primarily involved with internal managerial roles and work contacts. (CDD)

  18. Low-level waste packaging--a managerial perspective

    International Nuclear Information System (INIS)

    Motl, G.P.; Hebbard, L.B. Jr.

    1980-01-01

    This paper emphasizes managerial responsibility for assuring that facility waste is properly packaged. Specifically, existing packaging regulations are summarized, several actual violations are reviewed and, lastly, some recommendations are made to assist managerial personnel in fulfilling their responsibility to ensure that low-level waste is packaged safely and properly before shipment to the disposal site

  19. Evaluating Managerial Skills for Business Education in a ...

    African Journals Online (AJOL)

    This will go a long way in determining whether Business Education is still relevant in accomplishing its goals such as provision of managerial skills for economic sustainability. Based on the above, the researchers thought it reasonable to evaluate the managerial skills acquired through Business Education in present day ...

  20. Gender Influence On Managerial Efficiency Of Academic Librarians ...

    African Journals Online (AJOL)

    This study discusses the influences of gender on managerial efficiency of academic librarians in Nigeria. The rationale for the study was to investigate if gender grouping has an influence on the managerial competence of librarians in Nigeria. The total enumeration sampling technique with a questionnaire instrument was ...

  1. Preconditions of origin, essence and assignment of strategic managerial accounting

    OpenAIRE

    Boiko, I.

    2010-01-01

    The article is devoted to the research of preconditions and necessity of creation strategic managerial accounting in the accounting system of enterprise. There are investigated economic essence and assignment of strategic managerial accounting and substantiated its importance for making strategic decisions on an enterprise.

  2. Chosen methods and tools for measuring managerial competencies

    Directory of Open Access Journals (Sweden)

    Gabriela Roszyk-Kowalska

    2016-12-01

    Full Text Available In contemporary enterprises, a lot of attention is devoted to notions regarding human capital in an organization, putting increasingly higher emphasis on specific professional competences, especially to managerial ones, which are crucial in efficient management of human resources. To achieve satisfactory results, it is at first worth to get familiar with methods and tools, which thanks to scientific research, can be implemented into systems of improving managerial competences, assessing them and adjusting possibilities of elimination of disadvantages and improvement of manager’s assets. The article embraces an attempt to analyze research methods regarding managerial competences, because not only scientific staff works on development of new techniques referring to managerial competences, as such actions may be also identified in case of commercial advisory companies. A reason for searching for new tools lays in continuously increasing requirements, especially within the already competitive market of workers of managerial personnel.

  3. Economic Organization and Imperfect Managerial Knowledge

    DEFF Research Database (Denmark)

    Jensen, Henrik

    question guiding this effort is: What managerial challenges arise from having distributed knowledge within a firm and how does the manager’s knowledge of this knowledge matter for economic organization? The dissertation consists of three research papers, each exploring a dimension of the research question....... The first paper investigates antecedents of coordination break-down and how teams differ in their ability to coordinate specialized knowledge and skills. The second paper provides a theoretical framework for theorizing about the role of managers’ knowledge about employees’ knowledge for economic......When companies depend on knowledge distributed among employees, managers play a key role in establishing cooperation and coordination systems. This dissertation investigates the implications of managers’ knowledge about the knowledge and skills of employees for economic organization. The research...

  4. The Visual Image in Managerial Communication

    Directory of Open Access Journals (Sweden)

    Tudor Ioan

    2016-07-01

    Full Text Available The increasing proliferation and diversification of artificial languages have become a prerequisite for an efficient managerial discourse. The inclusion of language in a philosophy of management is justified by at least three reasons: language becomes the condition, the model and the object of scientific management. Implementing one�s management plan is consistent with the ability to send easily decipherable messages. It is a fact that one of the most important qualities of a leader is his or her ability to communicate. Career success is conditioned by facilitating the ease of communication between employees and superiors. Communication skills can lauch or ruin a career. Advances in messaging technology have a profound impact on our psychology. Communication through image, especially nowadays, is of particular importance. Included among the expressive behaviors, nonverbal communication is characterized by several aspects.

  5. HEDGE FUND MANAGERIAL INCENTIVES AND PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Nor Hadaliza ABD RAHMAN

    2011-07-01

    Full Text Available The growth of the hedge fund industry over the decades has brought an interesting form of performance contract between the portfolio managers and their investors. The contractual relation has given an impact to the performance of the hedge fund industry, which benefited both fund managers and investors. Furthermore, it has created more investors and fund managers to participate in this high risk and high return investment. Currently, many issues on fee structures and performancebased incentives have been discussed. Do these issues affect the performance of the hedge fund in the market? This paper will investigate the issues in Australian market. It will empirically analyze the hedge fund performance in relation to the market performance and whether managerial incentives and discretions associated with better fund performance.

  6. The laboratory workforce shortage: a managerial perspective.

    Science.gov (United States)

    Cortelyou-Ward, Kendall; Ramirez, Bernardo; Rotarius, Timothy

    2011-01-01

    Most clinical laboratories in the nation report severe difficulties in recruitment and retention of most types of personnel. Other important factors impacting this problem include work complexities, increased automation, and a graying workforce. As a further challenge, institutional needs for clinical laboratory personnel are expected to grow significantly in the next decade. This article examines the current situation of the clinical laboratory workforce. It analyzes the different types of personnel; the managerial, supervision, and line positions that are key for different types of laboratories; the job outlook and recent projections for different types of staff; and the current issues, trends, and challenges of the laboratory workforce. Laboratory managers need to take action with strategies suggested for overcoming these challenges. Most importantly, they need to become transformational leaders by developing effective staffing models, fostering healthy and productive work environments, and creating value with a strategic management culture and implementation of knowledge management.

  7. Relationships among measures of managerial personality traits.

    Science.gov (United States)

    Miner, J B

    1976-08-01

    Comparisons were made to determine the degree of convergence among three measures associated with leadership success in large, hierarchic organizations in the business sector: the Miner Sentence Completion Scale; the Ghiselli Self-Description Inventory; and the F-Scale, Correlational analyses and comparisons between means were made using college students and business manager samples. The results indicated considerable convergence for the first two measures, but not for the F-Scale. The F-Scale was related to the Miner Sentence Completion Scale in the student group, but relationships were nonexistent among the managers. Analyses of the individual F-Scale items which produced the relationship among the students suggested that early family-related experiences and attitudes may contribute to the development of motivation to manage, but lose their relevance for it later, under the onslaught of actual managerial experience.

  8. THE IMPACT OF MANAGERIAL COMPETENCIES ON THE MANAGERIAL PERFORMANCE IN THE EDUCATIONAL SYSTEM

    OpenAIRE

    Cristina, STAN

    2015-01-01

    The concept of competence in science education is in the midst of individual and collective performance. The complexity of the activity of running school has found a certain specific of its management that is materialized in two dimensions of the school activity: the variety of categories of staff and the interpersonal relationship, culture and work climate. All these result in the formation and development of a set of skills specific to the managerial field and necessary to the director of s...

  9. Long-term outcome and MGMT as a predictive marker in 24 patients with atypical pituitary adenomas and pituitary carcinomas given treatment with temozolomide

    DEFF Research Database (Denmark)

    Bengtsson, Daniel; Schrøder, Henrik Daa; Andersen, Marianne

    2015-01-01

    , GH 4, GH/PRL 2). Ki-67 was 2-50% in LAPTs, and 5-80% in carcinomas. MAIN OUTCOME: Response to TMZ and the association with tumor expression of O6-methylguanine DNA methyltransferase (MGMT), MLH1, MSH2, and MSH6, examined by immunohistochemistry. RESULTS: Complete tumor regression occurred in two...

  10. Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.

    Science.gov (United States)

    Ogino, Shuji; Kawasaki, Takako; Kirkner, Gregory J; Suemoto, Yuko; Meyerhardt, Jeffrey A; Fuchs, Charles S

    2007-11-01

    The CpG island methylator phenotype (CIMP or CIMP-high) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer. In contrast, a phenotype with less widespread promoter methylation (CIMP-low) has not been well characterised. O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and silencing have been associated with G>A mutations and microsatellite instability-low (MSI-low). To examine molecular correlates with MGMT methylation/silencing in colorectal cancer. Utilising MethyLight technology, we quantified DNA methylation in MGMT and eight other markers (a CIMP-diagnostic panel; CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) in 920 population-based colorectal cancers. Tumours with both MGMT methylation and loss were correlated positively with MSI-low (p = 0.02), CIMP-high (>or=6/8 methylated CIMP markers, p = 0.005), CIMP-low (1/8-5/8 methylated CIMP markers, p = 0.002, compared to CIMP-0 with 0/8 methylated markers), KRAS G>A mutation (p = 0.02), and inversely with 18q loss of heterozygosity (p = 0.0002). Tumours were classified into nine MSI/CIMP subtypes. Among the CIMP-low group, tumours with both MGMT methylation and loss were far more frequent in MSI-low tumours (67%, 12/18) than MSI-high tumours (5.6%, 1/18; p = 0.0003) and microsatellite stable (MSS) tumours (33%, 52/160; p = 0.008). However, no such relationship was observed among the CIMP-high or CIMP-0 groups. The relationship between MGMT methylation/silencing and MSI-low is limited to only CIMP-low tumours, supporting the suggestion that CIMP-low in colorectal cancer may be a different molecular phenotype from CIMP-high and CIMP-0. Our data support a molecular difference between MSI-low and MSS in colorectal cancer, and a possible link between CIMP-low, MSI-low, MGMT methylation/loss and KRAS mutation.

  11. MANAGERIAL COMMUNICATION - PREMISE FOR THE INCREASE OF ECONOMIC AGENTS’ PERFORMANCE

    Directory of Open Access Journals (Sweden)

    ADRIAN MOCANU

    2015-12-01

    Full Text Available Managerial communication is a vital factor in achieving maximum efficiency within an organization, its purpose being the achievement of correct, efficient and effective information both vertically and horizontally, in order to achieve optimal use of internal and external requirements and consistent with the established managerial and organizational objectives. In order to obtain a managerial communication leading to maximum results require a detailed analysis of the basic communicative activities of managers, analysis which represents, in fact, the purpose of this article. Keywords: communication, manager, efficiency, performance

  12. Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: An immunohistochemical study

    Science.gov (United States)

    Giaginis, Constantinos; Michailidi, Christina; Stolakis, Vasileios; Alexandrou, Paraskevi; Tsourouflis, Gerasimos; Klijanienko, Jerzy; Delladetsima, Ioanna; Theocharis, Stamatios

    2011-01-01

    Summary Background DNA repair is a major defense mechanism, which contributes to the maintenance of genetic sequence, and minimizes cell death, mutation rates, replication errors, DNA damage persistence and genomic instability. Alterations in the expression levels of proteins participating in DNA repair mechanisms have been associated with several aspects of cancer biology. The present study aimed to evaluate the clinical significance of DNA repair proteins MSH2, MLH1 and MGMT in benign and malignant thyroid lesions. Material/Methods MSH2, MLH1 and MGMT protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 90 patients with benign and malignant lesions. Results The expression levels of MLH1 was significantly upregulated in cases with malignant compared to those with benign thyroid lesions (p=0.038). The expression levels of MGMT was significantly downregulated in malignant compared to benign thyroid lesions (p=0.001). Similar associations for both MLH1 and MGMT between cases with papillary carcinoma and hyperplastic nodules were also noted (p=0.014 and p=0.026, respectively). In the subgroup of malignant thyroid lesions, MSH2 downregulation was significantly associated with larger tumor size (p=0.031), while MLH1 upregulation was significantly associated with the presence of lymphatic and vascular invasion (p=0.006 and p=0.002, respectively). Conclusions Alterations in the mismatch repair proteins MSH2 and MLH1 and the direct repair protein MGMT may result from tumor development and/or progression. Further studies are recommended to draw definite conclusions on the clinical significance of DNA repair proteins in thyroid neoplasia. PMID:21358597

  13. Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

    Science.gov (United States)

    Weller, Michael; Stupp, Roger; Hegi, Monika E.; van den Bent, Martin; Tonn, Joerg C.; Sanson, Marc; Wick, Wolfgang; Reifenberger, Guido

    2012-01-01

    Histological subtyping and grading by malignancy are the cornerstones of the World Health Organization (WHO) classification of tumors of the central nervous system. They shall provide clinicians with guidance as to the course of disease to be expected and the choices of treatment to be made. Nonetheless, patients with histologically identical tumors may have very different outcomes, notably in patients with astrocytic and oligodendroglial gliomas of WHO grades II and III. In gliomas of adulthood, 3 molecular markers have undergone extensive studies in recent years: 1p/19q chromosomal codeletion, O6-methylguanine methyltransferase (MGMT) promoter methylation, and mutations of isocitrate dehydrogenase (IDH) 1 and 2. However, the assessment of these molecular markers has so far not been implemented in clinical routine because of the lack of therapeutic implications. In fact, these markers were considered to be prognostic irrespective of whether patients were receiving radiotherapy (RT), chemotherapy, or both (1p/19q, IDH1/2), or of limited value because testing is too complex and no chemotherapy alternative to temozolomide was available (MGMT). In 2012, this situation has changed: long-term follow-up of the Radiation Therapy Oncology Group 9402 and European Organisation for Research and Treatment of Cancer 26951 trials demonstrated an overall survival benefit from the addition to RT of chemotherapy with procarbazine/CCNU/vincristine confined to patients with anaplastic oligodendroglial tumors with (vs without) 1p/19q codeletion. Furthermore, in elderly glioblastoma patients, the NOA-08 and the Nordic trial of RT alone versus temozolomide alone demonstrated a profound impact of MGMT promoter methylation on outcome by therapy and thus established MGMT as a predictive biomarker in this patient population. These recent results call for the routine implementation of 1p/19q and MGMT testing at least in subpopulations of malignant glioma patients and represent an encouraging

  14. SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer

    Science.gov (United States)

    Kuroiwa-Trzmielina, Joice; Wang, Fan; Rapkins, Robert W.; Ward, Robyn L.; Buchanan, Daniel D.; Win, Aung Ko; Clendenning, Mark; Rosty, Christophe; Southey, Melissa C.; Winship, Ingrid M.; Hopper, John L.; Jenkins, Mark A.; Olivier, Jake; Hawkins, Nicholas J.; Hitchins, Megan P.

    2016-01-01

    Purpose Methylation of the MGMT promoter is the major cause of O6-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter-enhancer SNP rs16906252C>T. We sought evidence for an association between the rs16906252C>T genotype and increased risk of developing a subtype of colorectal cancer (CRC) featuring MGMT methylation, mediated by genotype-dependent epigenetic silencing within normal tissues. Experimental design By applying a molecular pathological epidemiology case-control study design, associations between rs16906252C>T and risk for CRC overall, and CRC stratified by MGMT methylation status, were estimated using multinomial logistic regression in two independent retrospective series of CRC cases and controls. The test sample comprised 1054 CRC cases and 451 controls from Sydney, Australia. The validation sample comprised 612 CRC cases and 245 controls from the Australasian Colon Cancer Family Registry (ACCFR). To determine if rs16906252C>T was linked to a constitutively altered epigenetic state, quantitative allelic expression and methylation analyses were performed in normal tissues. Results An association between rs16906252C>T and increased risk of developing MGMT-methylated CRC in the Sydney sample was observed (OR 3.3; 95%CI=2.0–5.3; PT represents an expression and methylation quantitative trait locus. Conclusions We provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated CRC, likely mediated by constitutive epigenetic repression of the T allele. PMID:27267851

  15. Managerial leadership in the micro hermeneutics school

    Directory of Open Access Journals (Sweden)

    Elsy Rodriguez

    2016-12-01

    Full Text Available In the present work, we analyze in a theoretical way the micropolitics of the centers for understand the singularity in the school organization. The literature review leads to the conclusion, that while the struggle comply an important role in the political arena of the schools, this can be manage through the executive leadership, it’s a necessary role but not ever assumable by the school principals, on the other hand, the reflection around the issue put the conflict and leadership as a factor that influence in the social fabric of an educational community. The first is inherent in the daily dynamics of every organization, including the school, because emerges from the interaction between people, each one with ideologies and ways to read the reality in different way. Situation that gives rise to diversity of goals on which we must agree. Therefore, the negotiation that leads to the parties to reach agreement requires the exercise of a leadership from the management function to avoid polarization of ideas and eventually work for the common good. That is to say the leadership in the managerial function is an important role for promote dialogue in the centers, for motivate to the members of the educational community to participate in future changes, in benefit of all and not a few, and achieve consensus without this implying shield the democracy. 

  16. CONSIDERATIONS ON MANAGERIAL ETHICS IN SPORTS ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Mihai Constantin Razvan BARBU

    2012-01-01

    Full Text Available The scholarly literature in the ethics field approaches the ethical management issue in different areas such as accounting, retail, banking, public institutions or private companies. The subject of sports managers’ ethics is not very well highlighted in the national literature, as "sports industry" is constantly evolving. Sports have a strong impact on the national culture, influencing the values of millions of spectators and participants. The definition of sports given by the Council of Europe is "all forms of physical activity which, through more or less organized participation, aim at expressing or improving physical and psychological condition, the development of social relationships or obtaining positive results in all levels competitions". In this paper we conducted a study on managerial ethics tools within sports clubs. The used methodology involved the intersection of the main current stage of knowledge and the formulation of new judgments. The study identified and highlighted the major role of the manager of sports clubs in providing the framework for the manifestation of ethical behaviors.

  17. Lessons From Managerial Theories for Improving Virtualness in Electronic Business

    NARCIS (Netherlands)

    Wassenaar, Arjen; Govindaraju, Rajesri; Govindaraju, R.; Moreno Bragado, Elisa; Moreno Bragado, Elisa; von Raesfeld Meijer, Ariane M.; Ribbers, Pieter; Swagerman, D.M.; Sieber, Pascal; Griese, Joachim

    1998-01-01

    Electronic business and virtual organisations are important research topics in the IS research community today. At the same time these research topics are very appropriate for interdisciplinary research. The panel aims: - presentation of lessons from managerial theories for improving organisational

  18. THE IMPACT OF ORGANIZATION'S PERSONALITY ON MANAGERIAL BEHAVIOR

    Directory of Open Access Journals (Sweden)

    Costin Mădălina-Adriana

    2010-07-01

    Full Text Available Organizational climate and the conditions that determine the "personality" of an organization represent important factors in determining the managerial behavior. Climate and behaviors are strongly influenced by organizational culture. Managerial behavior is determined by the variety of ways of realizing functions and by their attitude to employees and subordinates. These features of the each manager’ behavior is defined management style. This study examined the relationship between individual’s personality, organization’s personality, the environmental factors and managerial behavior. Data were collected from thirty enterprises (micro, small and mediums from Bihor County. The results obtained from these sources suggested that the size of the lead group has a great influence on managerial behavior.

  19. Determinants of Quit Behavior Among Managerial and Professional Women

    Science.gov (United States)

    1986-12-01

    to socialization or discrimination is the major cause of women’s over representation in crowded occupations. Some studies relate the amount of specific...c.l ^16 Arrowood Determinan ^t:^ of quit behavior aifiong managerial and professional women.

  20. Influence of Managerial Accounting Skills on SME's on the Success ...

    African Journals Online (AJOL)

    Influence of Managerial Accounting Skills on SME's on the Success and ... SMEs such as strategic management, financial, marketing, human resource and ICT and ... A census research design was used, with a self administered questionnaire ...

  1. Financial Accountant Versus Managerial Accountant in the Hotel Business System

    Directory of Open Access Journals (Sweden)

    Ivana Zubac

    2012-01-01

    Full Text Available From the perspective of financial or managerial accountant, subject of interest in this paper is the relationship of financial and managerial accounting in the hotel business. Being necessary functions within the business system of hotel company, their mutual connection as well as their differences are explained. The management of hotel company makes decisions based on accounting information from both parts of accounting. As support to hotel management in decision-making, financial accountant provides financial information about past events, while managerial accountant provides non-financial information oriented toward future. The example above is just one out of many specific tasks, which are performed by accountants of specific part of hotel accounting system. Without their support, the management could not make correct and timely decisions with certainty. The importance of the roles of financial and managerial accountant is reflected through need for a wide knowledge in the field of accounting in specific business conditions of hotel industry.

  2. managerial ability and farming success : an analysis of small ...

    African Journals Online (AJOL)

    This research and analysis drew from the field of Industrial Psychology to determine and ... capital and sound financial structure within farmers' business, market access, ... managerial ability and strong entrepreneurial instinct; ability to handle.

  3. CONCEPTUAL ASPECTS ON MANAGERIAL ACCOUNTING AND ITS INFLUENCE ON MANAGEMENT

    Directory of Open Access Journals (Sweden)

    TIRAU ADRIAN IOAN

    2017-12-01

    Full Text Available Managerial accounting must be defined and analyzed as well as an integrated component in the decisionmaking process. Starting from this premise, we need to clearly highlight the role and objectives of managerial accounting. The importance of managerial accounting is highlighted by the challange that economic entities have to respond, to develop and substantiate optimal decisions and know how to select new initiatives to refocus their own activity. The important role played by managerial accounting and the calculation of costs in the decision-making process outlines the objectives of the research theme, objectives which, in order to be achived suppose the analyse of theoretical aspects existing in the national and international literature regarding to the organization of the management accounting and cost calculation.

  4. Senegalese Entrepreneurs in the USA and Managerial Decision ...

    African Journals Online (AJOL)

    sulaiman.adebowale

    2007-12-26

    Dec 26, 2007 ... and Managerial Decision making: A pilot study ... informal accounts by Senegalese themselves suggest a population reaching at least 4,000 .... unrestricted capacity to consider any information that may provide a better.

  5. Managerial capacity in the innovation process and firm profitability

    OpenAIRE

    Giovanni Cerulli; Bianca Potì

    2013-01-01

    This paper studies at firm level the relation between managerial capacity in doing innovation and profitability. Moving along the intersection between the evolutionary/neo-Schumpeterian theory and the Resource-Based-View of the firm, we prove econometrically that managerial efficiency in mastering the production of innovation is an important determinant of firm innovative performance and market success, and that it complements traditional Schumpeterian drivers. By using a Stochastic Frontier ...

  6. A methodology to measure the degre of managerial innovation

    Directory of Open Access Journals (Sweden)

    Mustafa Batuhan Ayhan

    2014-01-01

    Full Text Available Purpose: The main objective of this study is to introduce the concept of managerial innovation and to propose a quantitative methodology to measure the degree of managerial innovation capability by analyzing the evolution of the techniques used for management functions.Design/methodology/approach: The methodology mainly focuses on the different techniques used for each management functions namely; Planning, Organizing, Leading, Controlling and Coordinating. These functions are studied and the different techniques used for them are listed. Since the techniques used for these management functions evolve in time due to technological and social changes, a methodology is required to measure the degree of managerial innovation capability. This competency is measured through an analysis performed to point out which techniques used for each of these functions.Findings: To check the validity and applicability of this methodology, it is implemented to a manufacturing company. Depending on the results of the implementation, enhancements are suggested to the company for each function to survive in the changing managerial conditionsResearch limitations/implications: The primary limitation of this study is the implementation area. Although the study is implemented in just a single manufacturing company, it is welcomed to apply the same methodology to measure the managerial innovation capabilities of other manufacturing companies. Moreover, the model is ready to be adapted to different sectors although it is mainly prepared for manufacturing sector.Originality/value: Although innovation management is widely studied, managerial innovation is a new concept and introduced to measure the capability to challenge the changes occur in managerial functions. As a brief this methodology aims to be a pioneer in the field of managerial innovation regarding the evolution of management functions. Therefore it is expected to lead more studies to inspect the progress of

  7. A methodology to measure the degre of managerial innovation

    OpenAIRE

    Ayhan, Mustafa Batuhan; Oztemel, Ercan

    2014-01-01

    Purpose: The main objective of this study is to introduce the concept of managerial innovation and to propose a quantitative methodology to measure the degree of managerial innovation capability by analyzing the evolution of the techniques used for management functions.Design/methodology/approach: The methodology mainly focuses on the different techniques used for each management functions namely; Planning, Organizing, Leading, Controlling and Coordinating. These functions are studied and the...

  8. Comparative Analysis Of Online Recruitment And Managerial Capabilities

    OpenAIRE

    Roblyn Simeon

    2011-01-01

    On-line recruitment is a phenomenon that is not only changing the traditional approach to human resource management but is also having a significant impact on other business strategies. Managerial recruitment appears to be the area having the greatest influence on business strategy. We examined two theoretical perspectives that help to explain the importance in the U.S. of aggressive screening and competence matching as firms seek out exceptional managerial candidates. We then used data colle...

  9. Managerial Perspective on Open Source Collaboration and Networked Innovation

    OpenAIRE

    Henttonen Maaret Katja; Pasi Pussinen; Timo Koivumäki

    2012-01-01

    This study explores the managerial perspectives towards open source software and networked innovation. We analysed six software companies who use open source software as a significant part of their product or service offering. The study found notable differences in managerial attitudes, expected benefits and key challenges related to open source software and its role in innovative activities. While all companies were using same pieces of software with open source communities, there were diffe...

  10. Chosen methods and tools for measuring managerial competencies

    OpenAIRE

    Gabriela Roszyk-Kowalska

    2016-01-01

    In contemporary enterprises, a lot of attention is devoted to notions regarding human capital in an organization, putting increasingly higher emphasis on specific professional competences, especially to managerial ones, which are crucial in efficient management of human resources. To achieve satisfactory results, it is at first worth to get familiar with methods and tools, which thanks to scientific research, can be implemented into systems of improving managerial competences, assessing them ...

  11. The Managerial Approach in Public Administration Studies (II

    Directory of Open Access Journals (Sweden)

    Cristina MORA

    2002-06-01

    Full Text Available The current paper has analyzed in its first installment the causes for the decrease in the interest vested in scientific management, while accepting its virtues as the starting point for a managerial approach to public administration. This paper points out that the above-mentioned bureaucratic model is no match for the process of organizing public administration, when change in managerial terms is compulsory.

  12. Managerial incentives for attracting attention and firm investor base

    OpenAIRE

    Papiashvili, Nino

    2016-01-01

    This thesis studies how managerial incentives relate to strategic transmission of soft information from managers to investors in order to attract attention of financial markets. Additionally, I study trading reaction of different investors (large sophisticated vs. small individual) to CEO voluntary announcements and how their trading is affected when managerial incentives are taken into account. I use large panel data and several alternative proxies for soft information togethe...

  13. Accounting and reporting in small businesses: managerial aspect

    OpenAIRE

    Gogol Tatyana A.

    2013-01-01

    The article states that development of small businesses envisages formation and use of a wide spectrum of economic information for providing managerial structure with timely and quality information, which requires creation of a system of managerial accounting and reporting, which should not contradict to the principle of expenses – benefits relation, when expenses on introduction of such a system would exceed the effect obtained from its functioning. It adds that the main requirements of buil...

  14. Role of emotional intelligence in managerial effectiveness: An empirical study

    Directory of Open Access Journals (Sweden)

    Md. Sahidur Rahman

    2016-03-01

    Full Text Available Emotional intelligence is very critical to the managerial effectiveness. The present study intends to explore the relationships between emotional intelligence and the three roles such as, interpersonal, informational, and decision of managerial effectiveness. Emotional intelligence is measured by using the Emotional Quotient Index (Rahim et al., 2002 [Rahim, M., Psenicka, C., Polychroniou, P., Zhao, J., Yu, C., Chan, K., Susana, K., Alves, M., Lee, C., Rahman, M.S., Ferdausy, S., & Wyk, R. (2002. A model of emotional intelligence and conflict management strategies: a study in seven countries. International Journal of Organizational Analysis, 10(4, 302-326.] while managerial effectiveness is assessed by using Tsui’s (1984 scale [Tsui, A.S. (1984. A role set analysis of managerial reputation. Organizational Behavior and Human Performance, 34, 64-96.]. Data were collected by distributing self-administered questionnaires among the working MBA students using a convenience sampling technique. Respondents are asked to rate their emotional intelligence and managerial effectiveness scales. Finally 127 usable responses are received and, then, analyzed by using the descriptive statistics, bivariate correlation, and regression analysis. Analysis shows that emotional intelligence was positively related with interpersonal role, informational role, and decision role. The main implication is that emotional intelligence could enhance managerial effectiveness guiding the managers, academics, and professionals. The limitations are the sample size and the sampling technique which might limit the generalizability of the findings. Future directions are also discussed.

  15. Managerial functions of organizing and leading people in MLM organizations and their manifestations in historical schools of managerial thinking

    OpenAIRE

    Košnarová, Zita

    2013-01-01

    The article looks into managerial functions of organizing and leading in multilevel marketing (MLM) organizations, focusing on the creation of organizational structures and the style of leadership. Paper is trying to identify what historical trends of managerial thinking these functions are derived from and what other trends influenced them. The functions are studied in a concrete MLM organization in which the organizational structure and the style of leading people are defined. The article d...

  16. Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking

    Directory of Open Access Journals (Sweden)

    Guohui Sun

    2016-06-01

    Full Text Available DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT, which plays an important role in inducing drug resistance against alkylating agents that modify the O6 position of guanine in DNA, is an attractive target for anti-tumor chemotherapy. A series of MGMT inhibitors have been synthesized over the past decades to improve the chemotherapeutic effects of O6-alkylating agents. In the present study, we performed a three-dimensional quantitative structure activity relationship (3D-QSAR study on 97 guanine derivatives as MGMT inhibitors using comparative molecular field analysis (CoMFA and comparative molecular similarity indices analysis (CoMSIA methods. Three different alignment methods (ligand-based, DFT optimization-based and docking-based alignment were employed to develop reliable 3D-QSAR models. Statistical parameters derived from the models using the above three alignment methods showed that the ligand-based CoMFA (Qcv2 = 0.672 and Rncv2 = 0.997 and CoMSIA (Qcv2 = 0.703 and Rncv2 = 0.946 models were better than the other two alignment methods-based CoMFA and CoMSIA models. The two ligand-based models were further confirmed by an external test-set validation and a Y-randomization examination. The ligand-based CoMFA model (Qext2 = 0.691, Rpred2 = 0.738 and slope k = 0.91 was observed with acceptable external test-set validation values rather than the CoMSIA model (Qext2 = 0.307, Rpred2 = 0.4 and slope k = 0.719. Docking studies were carried out to predict the binding modes of the inhibitors with MGMT. The results indicated that the obtained binding interactions were consistent with the 3D contour maps. Overall, the combined results of the 3D-QSAR and the docking obtained in this study provide an insight into the understanding of the interactions between guanine derivatives and MGMT protein, which will assist in designing novel MGMT inhibitors with desired activity.

  17. Economic and Managerial Analysis of Effective Managerial Strategies on Prevention from Ketosis in Transition Period in Shahroud Commercial Dairy Farms

    Science.gov (United States)

    Kashfi, H.; Yazdani, A. R.; Latifi, M.; Shirani Bidabadi, F.

    2011-01-01

    The purpose of this research is to study any effects of managerial strategies on prevention of ketosis metabolic disorder in transition period in Shahroud commercial dairy farms. For this purpose, a questionnaire was prepared in order to obtain required information about the performance of these managerial strategies, performance costs, involvement situation with disorders relying upon clinical signs and treatment and health records, producing and economic situation, and fertility rate and its costs. The considered managerial guidelines include body condition score management or type evaluation in transition period, increase in dry matter intake close to parturition, using propylene glycol, using niacin, and high-quality feeding (the importance of feed quality) in transition period. Finally and upon arrangement of data, it was possible to study any effects of mentioned managerial strategies on related variants through multiple linear regressions. Furthermore, in order to study any relation among variables, we considered Pearson correlation coefficients as well. Finally, it was revealed that any application of managerial strategies for prevention from Ketosis in transition period has a significant effect in betterment of managerial and economic parameters. PMID:23738102

  18. Evolution of managerial problems from the perspective of management science

    Directory of Open Access Journals (Sweden)

    Marek Szarucki

    2015-12-01

    Full Text Available Managerial problems and the process of their solving play an important role both in the theory of management science and practice of organisations’ functioning. There is a gap in the literature related to the evolution of management problems in the context of the methodological approaches to solve them. The main goal of this paper was to analyse the evolution of the managerial problems from the perspective of management science and to present dominant methodological approaches for problem solving. Based on the extensive literature analysis in the discipline of management science, the evolution of the managerial problems was described with relation to the sixteen streams of management science. The author reviewed the selected classifications of the management theory as well as proposed his own perspective, which took into account managerial problems and their evolution over time. Moreover, there was presented an attempt to depict sources of management problems from the historical perspective within the methodological approaches of management science. Despite the broad view on management problems presented in this paper, such perspective gives a good ground for developing new more specific problem classifications, addressing different facets of managerial problems.

  19. Hospital management training and improvement in managerial skills: Serbian experience.

    Science.gov (United States)

    Supic, Zorica Terzic; Bjegovic, Vesna; Marinkovic, Jelena; Milicevic, Milena Santric; Vasic, Vladimir

    2010-06-01

    The purpose of this study was to analyze the improvement of managerial skills of hospitals' top managers after a specific management training programme, and to explore possible predictors and relations. The study was conducted during the years 2006 and 2007 with cohort of 107 managers from 20 Serbian general hospitals. The managers self-assessed the improvement in their managerial skills before and after the training programme. After the training programme, all managers' skills had improved. The biggest improvement was in the following skills: organizing daily activities, motivating and guiding others, supervising the work of others, group discussion, and situation analysis. The least improved were: applying creative techniques, working well with peers, professional self-development, written communication, and operational planning. Identified predictors of improvement were: shorter years of managerial experience, type of manager, type of profession, and recognizing the importance of the managerial skills in oral communication, evidence-based decision making, and supervising the work of others. Specific training programme related to strategic management can increase managerial competencies, which are an important source of competitive advantage for organizations. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

  20. PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma

    Science.gov (United States)

    Sharpe, Martyn A.; Raghavan, Sudhir; Baskin, David S.

    2018-01-01

    Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. In addition to elevation of O6-methylguanine DNA methyltransferase (MGMT), down-regulation of three DNA repair pathways; canonical mismatch repair (MMR), Non-Homologous End-Joining (NHEJ), and Homologous Recombination (HR) are correlated with poor patient outcome. We have designed and tested both in vitro and in vivo, a monoamine oxidase B (MAOB) specific prodrug, PAM-OBG, that is converted by glioma MAOB into the MGMT inhibitor O6-benzylguanine (O6BG) and the DNA crosslinking agent acrolein. In cultured glioma cells, we show that PAM-OBG is converted to O6BG, inhibiting MGMT and sensitizing cells to DNA alkylating agents such as BCNU, CCNU, and Temozolomide (TMZ). In addition, we demonstrate that the acrolein generated is highly toxic in glioma treated with an inhibitor of Nucleotide Excision Repair (NER). In mouse intracranial models of primary human glioma, we show that PAM-OBG increases survival of mice treated with either BCNU or CCNU by a factor of six and that in a chemoradiation model utilizing six rounds of TMZ/2Gy radiation, pre-treatment with PAM-OBG more than doubled survival time. PMID:29844863

  1. Performance assessment of Portuguese wind farms: Ownership and managerial efficiency

    International Nuclear Information System (INIS)

    Pestana Barros, Carlos; Sequeira Antunes, Olinda

    2011-01-01

    This paper analyzes ownership and unobserved managerial ability as factors affecting the performance of a representative sample of Portuguese wind farms by means of frontier models. These farms are ranked according to their technical efficiency during the period 2004-2008 and homogenous and heterogeneous variables are disentangled in the cost function, which leads us to advise the implementation of common policies as well as policies by segments. Economic implications arising from the study are also considered. - Research highlights: → Wind farms are heterogeneous displaying distinct ownership and managerial characteristics that affect efficiency. → Managerial practices has a positive impact on the efficiency. → Ownership has a positive impact on the efficiency. Large wind farms are more efficient.

  2. Managerial Perspective on Open Source Collaboration and Networked Innovation

    Directory of Open Access Journals (Sweden)

    Henttonen Maaret Katja

    2012-09-01

    Full Text Available This study explores the managerial perspectives towards open source software and networked innovation. We analysed six software companies who use open source software as a significant part of their product or service offering. The study found notable differences in managerial attitudes, expected benefits and key challenges related to open source software and its role in innovative activities. While all companies were using same pieces of software with open source communities, there were different levels of engagement in the development of the software and information flows between companies and communities. A deeper level of involvement enables the exchange of more than just the code: like ideas, influences, opinions and even innovations or parts of them. The differences in managerial views on open source and networked innovation may be explained by industry domains, value chain position and leadership style

  3. Understanding the managerial state: a few theoretical tools

    Directory of Open Access Journals (Sweden)

    Iana Gomes de Lima

    2012-06-01

    Full Text Available This article offers theoretical tools to the analysis of the state and contemporary public policies, with special attention to educational policies. Utilizing mainly the contribution of John Clarke and Janet Newman and adding the concepts used by Michael Apple and Stephen Ball, this article offer theoretical lenses to theexamination of the managerial nature of the contemporary state. Through the dispersal of power, the blurring of the borders between public and private and assessment policies that control the action of public institutions, the managerial state fi ghts the Welfare State and creates the conditions to public policies that reshape the relationship between civil society and the state. The article ends with some implications to the study of educational policies, emphasizing the fact that the managerial logic does not transfer, unmediated, to all state actions.

  4. Does managerial turnover affect football club share prices?

    OpenAIRE

    Bell, Adrian; Brooks, Chris; Markham, Tom

    2013-01-01

    This paper analyses the 53 managerial sackings and resignations from 16 stock\\ud exchange listed English football clubs during the nine seasons between 2000/01 and\\ud 2008/09. The results demonstrate that, on average, a managerial sacking results in a\\ud post-announcement day market-adjusted share price rise of 0.3%, whilst a resignation\\ud leads to a drop in share price of 1% that continues for a trading month thereafter,\\ud cumulating in a negative abnormal return of over 8% from a trading ...

  5. Contributions to the Definition of the Managerial Profiles

    Directory of Open Access Journals (Sweden)

    Dan Constantinescu

    2008-01-01

    Full Text Available Considering that the superior manager variety is a result of the different levels of “accommodation” of the characteristics met in the dedicated literature, in the beginning we have summed up the opinions of the subjects of a statistical research in some managerial profiles, closer to the real life. The same procedure was applied in middle management, making some adjustments regarding the main characteristics. The last part of the study is dedicated to define the best performing managerial teams (tandems, reported to the role of the two representatives of the organizational structures in accomplishing the general objectives of each company.

  6. MANAGERIAL ACCOUNTING AND ENVIRONMENTAL PERFORMANCE OF BAKERY COMPANIES

    Directory of Open Access Journals (Sweden)

    Marian TAICU

    2012-09-01

    Full Text Available The complexity of the economic life, the economic and financial crisis and the social and environmental problems determine the increase in the role of information provided by managerial accounting in decision-making. The efficient management of any economic unit is based on the existence of a well structured information system, according to managers’ information needs, the main component of such system being accounting. The article aims at clarifying certain aspects concerning the role of managerial accounting in the correct assessment and in managing performance in bakery companies.

  7. Surgical center: challenges and strategies for nurses in managerial activities.

    Science.gov (United States)

    Martins, Fabiana Zerbieri; Dall'Agnoll, Clarice Maria

    2017-02-23

    Analyze the challenges and strategies of nurses performing managerial activities in a surgical center. Exploratory, descriptive study with a qualitative approach, involving six nurses by means of the Focus Group Technique, between April and August 2013. Data were submitted to thematic content analysis. The main challenges noted were deficiency of material resources, communication noise, adequacy of personnel downsizing, and relationships with the multidisciplinary team. Key strategies include construction of co-management spaces to promote integration among professionals, conflict resolution and exchange of knowledge. Managerial activities involve the promotion of dialogic moments to coordinate the different processes in the surgical center to provide inputs to expand safety and quality of services provided.

  8. Exploring Managerial Mechanisms That Influence Innovative Work Behavior

    DEFF Research Database (Denmark)

    Bysted, Rune; Jespersen, Kristina Risom

    2014-01-01

    Increasing employees’ innovative work behaviour is a complex process of developing an internal climate supportive of idea generation and realization through use of financial, participative, and decentralization mechanisms. This article investigates the effectiveness of these managerial mechanisms...... as extra-role behaviour to be compensated for. Private employees recognize innovative work behaviour as necessary behaviour for career advancement....

  9. Managerial autonomy, optimal security issuance and capital structure

    NARCIS (Netherlands)

    Boot, A.W.A.; Thakor, A.V.

    2005-01-01

    In this paper we address two related puzzles: (i) why do firms issue equity when stock prices are high and (ii) why do firms so often not issue securities to counteract the mechanical effect of their stock returns on their leverage ratios? Our theory builds on the importance of managerial autonomy

  10. Investment and Internal Finance: Asymmetric Information or Managerial Discretion?

    NARCIS (Netherlands)

    H. Degryse (Hans); A. de Jong (Abe)

    2001-01-01

    textabstractThis paper examines the relation between cash-flow availability and investment spending in the Netherlands. In particular, we are interested whether managerial discretion and/or asymmetric information drive the positive relation between cash-flow and investment spending. This relation

  11. Essays on the role of managerial type in financial reporting

    NARCIS (Netherlands)

    Jia, Y.

    2008-01-01

    In this dissertation, I combine two methodologies to venture a first attempt to explore the effect of managerial type on accounting quality. In an experimental study, I show that incentive compensation and social context (i.e., the behavior of other managers in the firm) are associated with how

  12. Valuing Professional, Managerial and Administrative Staff in HE

    Science.gov (United States)

    Duncan, David

    2014-01-01

    The article explores the role of the Registrar (Chief Operating Officer) in a university, and the ways in which we value the contributions of professional, managerial and administrative (PMA) staff. It assesses the conditions in which PMA staff work and describes the professional development opportunities they enjoy. The article goes on to analyse…

  13. Gendered Managerial Discourses in Sport Organizations: Multiplicity and Complexity

    NARCIS (Netherlands)

    Knoppers, Annelies; Anthonissen, A.

    2007-01-01

    The lack of women in senior management functions in sport may in part be attributed to dominant discursive managerial practices in sport organizations. The purpose of this study is to explore ways in which the discourses and their subtexts used by directors of Dutch national sport organizations

  14. Do the Managerial Characteristics of Schools Influence Their Performance?

    Science.gov (United States)

    Agasisti, Tommaso; Bonomi, Francesca; Sibiano, Piergiacomo

    2012-01-01

    Purpose: The purpose of this paper is to investigate the role of governance and managerial characteristics of schools. More specifically, the aim is to individuate the factors that are associated to higher schools' performances, as measured through student achievement. Design/methodology/approach: The research is conducted by means of a survey in…

  15. The Managerial Behavior of Secondary School Heads in Punjab (Pakistan)

    Science.gov (United States)

    Naeemullah, Khan; Muhammad, Inamullah Hafiz; Muhammad, Sarwar; Uddin, Muhammad Naseer; Shafqat, Hussain

    2010-01-01

    The purpose of the study was to explore the perception of secondary school heads and their managerial roles. The sample of the study consisted of 56 school heads including 34 males and 22 females. A five-point scale was designed by the researchers for data collection. One of the researchers personally collected and recorded the information from…

  16. Coping With Change And Globalisation: A Study Of Managerial ...

    African Journals Online (AJOL)

    This paper draws in part on the findings from a study of managerial perceptions of Globalisation-related business issues in the island of Mauritius. The objectives of the research were to determine the degree of awareness of Mauritian senior executives regarding the Globalisation issue, and to investigate the difficulties and ...

  17. Matching Managerial Skills and Behaviour with Business Strategy ...

    African Journals Online (AJOL)

    ... number of authors. The paper then concludes that matching a manager to a business strategy needs learning. However managerial characteristics are difficult to change as business change. At best the matching concepts suits manual and technical jobs. African Journal of Finance and Management Vol.8(2) 2000: 32-36 ...

  18. Food quality management : A techno-managerial approach

    NARCIS (Netherlands)

    Luning, P.A.; Marcelis, W.J.; Jongen, W.M.F.

    2002-01-01

    The book focuses on consumer-driven Quality Management in food production systems using a product-based approach. It integrates organizational and technological aspects of food product quality into one techno-managerial concept and it presents an integrated view of how Quality Management is to be

  19. Food quality management : a technological and managerial principles and practices

    NARCIS (Netherlands)

    Luning, P.A.; Marcelis, W.J.

    2009-01-01

    This book describes Food Quality Management in one integrated concept. Firstly, all relevant aspects of food quality management are brought into one model, which forms the framework for this book. Secondly, the authors introduce the techno-managerial approach. This approach starts from the idea that

  20. Perceptions of Women's Communication Skills Related to Managerial Effectiveness.

    Science.gov (United States)

    Berryman-Fink, Cynthia

    In a study designed to document empirically perceptions about women managers' communication skills and training needs, 101 managers (53 females and 48 males) responded to two open-ended questions: (1) From your observation and experience, what specific communication skills do women possess that might help promote their managerial effectiveness?…

  1. Essays of Executive Compensation - Managerial Incentives and Disincentives

    NARCIS (Netherlands)

    K-C. Yu (Ko-Chia)

    2011-01-01

    textabstractExecutive compensation has been a central point of debates for the past 20 years, both in the academic circle and in Wall Street Journal. Have shareholders paid too much to the CEOs, or are the pay packages necessary for recruiting and keeping managerial talents? Are the structures

  2. Control by Numbers: New Managerialism and Ranking in Higher Education

    Science.gov (United States)

    Lynch, Kathleen

    2015-01-01

    This paper analyses the role of rankings as an instrument of new managerialism. It shows how rankings are reconstituting the purpose of universities, the role of academics and the definition of what it is to be a student. The paper opens by examining the forces that have facilitated the emergence of the ranking industry and the ideologies…

  3. The influence of principal managerial task performance on ...

    African Journals Online (AJOL)

    Poor performance of managerial tasks culminates declining staff productivity and thus deteriorating students academic performance. Secondary school students performance in most public examinations are not satisfactory in most states in Nigeria. Hence, this study investigate the extent to which secondary school principal ...

  4. Managerial autonomy, allocation of control rights, and optimal capital structure

    NARCIS (Netherlands)

    Boot, A.W.A.; Thakor, A.V.

    2011-01-01

    We examine the design of control rights of external financiers, and how these interact with the firm's security issuance and capital structure when the firm's initial owners and managers may disagree with new investors over project choice. The first main result is an ex ante managerial preference

  5. Local School Micropolitical Agency: An Antidote to New Managerialism

    Science.gov (United States)

    Johnson, Bruce

    2004-01-01

    This paper reports research into the micropolitical strategies used by five school leadership teams in the South Australian School-based Research and Reform Project. The research challenges many of the orthodoxies of educational managerialism. For example: the use of leadership teams made up of teachers, coordinators and senior school leaders…

  6. Managerial Cost Accounting for a Technical Information Center.

    Science.gov (United States)

    Helmkamp, John G.

    A two-fold solution to the cost information deficiency problem is proposed. A formal managerial cost accounting system is designed expressly for the two information services of retrospective search and selective dissemination. The system was employed during a trial period to test its effectiveness in a technical information center. Once…

  7. Employability, Managerialism, and Performativity in Higher Education: A Relational Perspective

    Science.gov (United States)

    Kalfa, Senia; Taksa, Lucy

    2017-01-01

    This article combines Bourdieu's concepts of field, habitus and cultural capital with Lyotard's account of performativity to construct a three-tiered framework in order to explore how managerialism has affected the academic habitus. Specifically, this article examines the adoption of group assignments as a means of developing teamwork skills in…

  8. Managerial Accounting in Library and Information Science Education.

    Science.gov (United States)

    Hayes, Robert M.

    1983-01-01

    Explores meaning of managerial accounting in libraries and discusses instructional program for students of library and information science based on experience in School of Library and Information Science at University of California, Los Angeles. Management decision making (budgeting, performance evaluation, overhead, resource allocation,…

  9. Identification of Managerial Competencies in Knowledge-based Organizations

    Directory of Open Access Journals (Sweden)

    Königová Martina

    2012-03-01

    Full Text Available Managerial competencies identification and development are important tools of human resources management that is aimed at achieving strategic organizational goals. Due to current dynamic development and changes, more and more attention is being paid to the personality of managers and their competencies, since they are viewed as important sources of achieving a competitive advantage. The objective of this article is to identify managerial competencies in the process of filling vacant working positions in knowledge-based organizations in the Czech Republic. The objective was determined with reference to the Czech Science Foundation GACR research project which focuses on the identification of managerial competencies in knowledge-based organizations in the Czech Republic. This identification within the frame of the research project is primarily designed and subsequently realised on the basis of content analysis of media communications such as advertisements - a means through which knowledge- based organizations search for suitable candidates for vacant managerial positions. The first part of the article deals with theoretical approaches to knowledge-based organizations and issues on competencies. The second part evaluates the outcomes of the survey carried out, and also summarizes the basic steps of the application of competencies. The final part summarizes the benefits and difficulties of applying the competency-based approach as a tool of efficient management of organizations for the purpose of achieving a competitive advantage.

  10. Performance Management, Managerial Authority, and Public Service Performance

    DEFF Research Database (Denmark)

    Nielsen, Poul Aaes

    2014-01-01

    that managerial authority over human resources positively moderates the effect of performance management, whereas decentralizing goal setting works in the opposite direction. These findings may help account for the differing effects of performance management found in previous studies and suggest that decision...

  11. Giving meaning to sport involvement in managerial work

    NARCIS (Netherlands)

    Knoppers, A.E.|info:eu-repo/dai/nl/151627576

    2009-01-01

    I use a discursive analytical approach to explore ways in which senior managerial men working in nonprofit organizations understand the contribution, if any, of their own sport history to their work skills, how this may vary by organizational contexts and how the subtexts of these discourses may

  12. Capital Structure and Managerial Compensation : The Effects of Renumeration Seniority

    NARCIS (Netherlands)

    Calcagno, R.; Renneboog, L.D.R.

    2004-01-01

    We show that the relative seniority of debt and managerial compensation has important implications on the design of remuneration contracts.Whereas the traditional literature assumes that debt is senior to remuneration, we show that this is frequently not the case according to bankruptcy regulation

  13. The Managerial Grid; Key Orientations for Achieving Production through People.

    Science.gov (United States)

    Blake, Robert R; Mouton, Jane S.

    The Managerial Grid arranges a concern for production on the horizontal axis and a concern for people on the vertical axis of a coordinate system: 1,1 shows minimum concern for production and people; 9,1 shows major production emphasis and minimum human considerations; 1,9 shows maximum concern for friendly working conditions and minimum…

  14. Capital Structure and Managerial Compensation: the Effects of Remuneration Seniority

    NARCIS (Netherlands)

    Calcagno, R.; Renneboog, L.

    2007-01-01

    We show that the relative seniority of debt and managerial compensation has important implications for the design of remuneration contracts. Whereas the traditional literature assumes that debt is senior to remuneration, there are in reality many cases in which remuneration contracts are de facto

  15. Influence of managerial beliefs and personality on the leadership ...

    African Journals Online (AJOL)

    The study examined the influence of managerial beliefs and personality on leadership styles of managers in manufacturing and service organizations. Two hundred and three (203) managers participated110. (54.2%) were males and 93 (45.8%) were females. Managers from service organizations were 115 (56.7%) and ...

  16. Developing the Image and Public Reputation of Universities: The Managerial Process.

    Science.gov (United States)

    Davies, John L.; Melchiori, Gerlinda S.

    1982-01-01

    Managerial processes used in developing programs to improve an institution's public image are outlined, drawing on both theory and experience in college administration and public relations. Eight case studies provide illustrations. A five-stage managerial plan is presented. (MSE)

  17. Using Social Media as a Managerial Platform for an Educational Development Project : Cofimvaba

    CSIR Research Space (South Africa)

    Van der Vyver, AG

    2015-12-01

    Full Text Available of the project use Whatsapp, a popular social media platform to engage in managerial communication. The researchers found that this unconventional platform proved to be an excellent anchor for managerial communication on the project....

  18. Avaliação da expressão do gene MGMT nos tecidos normal e neoplásico de doentes com câncer colorretal

    Directory of Open Access Journals (Sweden)

    Adriana Teixeira Cordeiro

    Full Text Available OBJETIVO: Avaliar a expressão tecidual do gene de reparo MGMT comparando a mucosa cólica normal e neoplásica em doentes com câncer colorretal. MÉTODOS: Foram estudados 44 portadores de adenocarcinoma colorretal confirmado por estudo histopatológico. Foram excluídos doentes suspeitos de pertencerem a famílias com câncer colorretal hereditário (HNPCC e PAF e os portadores de câncer do reto médio e inferior submetidos a tratamento quimioradioterápico neoadjuvante. A expressão do gene MGMT foi avaliada pela técnica da reação de polimerase em cadeia em tempo real (RT-PCR. A comparação dos resultados encontrados para expressão do gene MGMT entre tecidos normais e neoplásicos foi feita pelo teste t de Student pareado, adotando-se nível de significância de 5% (p <0,05. RESULTADOS: A expressão tecidual do gene MGMT em todos os doentes foi menor no tecido neoplásico quando comparada a do tecido normal (p=0,002. CONCLUSÃO: O gene de reparo MGMT encontra-se menos expresso no tecido neoplásico quando comparados aos tecidos normais em portadores de CCR esporádico.

  19. Teacher’s asserting premises and possibilities of efficient managerial styles

    OpenAIRE

    Claudiu Marian Bunăiașu

    2014-01-01

    The issue of teacher's managerial styles is unitary approached along with educational styles issue and institutional management styles issue, and is part of the class' managerial dimension. Comparative, educational and managerial styles (of the school manager) have a theoretical history and benefit from validated techniques and tools, whereas teacher's managerial styles issue are about to gain consistency as part of the pedagogical literature, and present researches emphasize their roles in e...

  20. Aspects of the Normalization of Managerial Accounting in Romania on a Microeconomic Level

    Directory of Open Access Journals (Sweden)

    Sorin BRICIU

    2011-03-01

    Full Text Available The article presents the general frame of the normalization of managerial accounting on a national level, following an incursion in its international normalization. The objectives of the normalization of managerial accounting in Romania are presented into detail, from the authors’ point of view, as well as the profile and attributions of the managerial accountant as a normalizer. The article ends with the authors’ conclusions related to the normalization of managerial accounting in Romania on a microeconomic level.

  1. Traditional Vs. Contemporary Managerial/Cost Accounting Techniques Differences Between Opinions Of Educators And Practitioners

    OpenAIRE

    M. A. Ekbatani; M. A. Sangeladji

    2011-01-01

    From the mid 1980s, the start of new movements in the field of managerial/cost accounting, a gap has emerged between the opinions of academia and practitioners regarding the degree of usefulness of managerial/cost accounting techniques. It is believed that practitioners generally prefer managerial/cost accounting techniques which are simple, practical and economically applicable. On the other hand, many authors and academia believe that the traditional managerial/cost accounting techniques ar...

  2. MAXIMIZATION OF DNA DAMAGE TO MGMT(+ EGFR(+ GBM CELLS USING OPTIMAL COMBINATION OF TEMOZOLOMIDE-ANTI EGFR MONOCLONAL ANTIBODY NIMOTUZUMAB

    Directory of Open Access Journals (Sweden)

    M. A. M. Inggas

    2015-09-01

    Full Text Available Background: Glioblastoma multiforme (GBM is the most aggressive primary brain tumor in adultswith dismal prognosis due to the unavailability of an effective therapy. Up to now, there had been no definitive studies published on EGFR inhibition therapy as a chemosensitizer for GBM therapy using Temozolomide (TMZ. This study aims to reveal the most effective method and timing to administer TMZ-anti EGFR targeted therapy which causes maximal DNA damage on GBM cells.Methods: Various regimens of anti EGFR monoclonal antibody Nimotuzumab (NMZ was administered in different combinations with TMZ, performed on U87MG MGMT(+ EGFR(+ cells. The effectiveness of the combinations were evaluated by measuring yH2AX levels which reflects the degree of DNA damage. One-way Anova and LSD tests were performed to determine the effects of each treatment with p<0.05. Results and discussion: the mean SD of yH2AX of each treatment was: 11,90±1,25 for the control group; 29.33±1.91 for NMZ alone; 28.13±1.58 for TMZ alone; 41.53±3.51 for concurrent use; 35.67 ±2.65 for NMZ after 24 hours TMZ; 31.87±2.94 for NMZ after 48 hours TMZ; 39.57±4.2 for TMZ after 24 hours NMZ; and 35.93 ±3.56 for TMZ after 48 hours NMZ. The administration of TMZ concurrent with or after 24 hours NMZ gives the highest amount of DNA damage to GBM cells. Conclusion: The administration of Nimotuzumab targeted therapy up to 24 hours before Temozolomide chemotherapy has been proven to be effective in maximizing the amount of DNA damage done to GBM cells in vitro. 

  3. Dynamic Planning of Experiments for the Optimisation of Managerial Scheduling

    Directory of Open Access Journals (Sweden)

    Tomáš Macák

    2016-01-01

    Full Text Available Time management has a crucial role in organizations and also in our personal lives. Managerial scheduling is an important tool for the time management, especially It can serve as a tool for the first phase, of time management - namely for effective planning. This paper focusses on finding the best possible setting for determining significant the best layout for activities according to the criteria of urgency and importance using a modified steepest ascent method, which can be referred as dynamic scheduling. This term indicates the nature of the method; wherein the experimental design space is changed to look for the best conditions for adjustment factors influencing a managerial process. Existing methods for layout optimization mentioned in the literature and conventionally implemented in practice have only shown local optima.

  4. Driving Strategic Risk Planning With Predictive Modelling For Managerial Accounting

    DEFF Research Database (Denmark)

    Nielsen, Steen; Pontoppidan, Iens Christian

    for managerial accounting and shows how it can be used to determine the impact of different types of risk assessment input parameters on the variability of important outcome measures. The purpose is to: (i) point out the theoretical necessity of a stochastic risk framework; (ii) present a stochastic framework......Currently, risk management in management/managerial accounting is treated as deterministic. Although it is well-known that risk estimates are necessarily uncertain or stochastic, until recently the methodology required to handle stochastic risk-based elements appear to be impractical and too...... mathematical. The ultimate purpose of this paper is to “make the risk concept procedural and analytical” and to argue that accountants should now include stochastic risk management as a standard tool. Drawing on mathematical modelling and statistics, this paper methodically develops risk analysis approach...

  5. New Forms of Managerial Education in Knowledge Society

    Science.gov (United States)

    Maly, Milan

    Paper illustrates the ways of knowledge sharing in transition companies in two main topics: the methods of knowledge management of local managers in joint ventures with foreign partners from free market countries and the development of leadership behavior and decision making styles in privatized companies in the Czech Republic. Lack of previous experience is the main reason for the adoption of different ways of managerial education. Several systems like the tandem, distant learning, mixed, foreign and hired managerial systems are analyzed, and the role of both partners, local and foreign managers, is specified. The analysis of leadership behavior and decision-making styles specifying five levels of participation. Czech managers consider it to be appropriate to use a more autocratic style than a participative one. Only in a few cases, mostly in joint ventures, can we see some elements of the partnership style.

  6. Managerial competence at senior levels of integrated delivery systems.

    Science.gov (United States)

    Longest, B B

    1998-01-01

    The advent of integrated delivery systems (IDSs) in the healthcare industry has changed much about the work involved in running many healthcare organizations. As a result of these changes, senior healthcare managers in IDSs need different skills and knowledge (competencies) than managers of other healthcare systems. The work of managers is changed by the shift to more organizational integration in the healthcare industry because they become responsible for coordinated continuation of services, accountable for the overall health status of the populations they serve, and involved in more complex organizational structures. The article identifies six distinct managerial competencies--conceptual, technical managerial/clinical, interpersonal/collaborative, political, commercial, and governance--and describes how they relate to an IDS senior manager's successful work performance. The implications of these competencies are considered for practicing senior managers in IDSs, as well as those who aspire to such positions, and those who help educate them.

  7. Measuring the effect of managerial ability on earning quality

    Directory of Open Access Journals (Sweden)

    Jamal Bahri Sales

    2015-09-01

    Full Text Available This paper presents an empirical investigation to measure the effect of managerial ability on earning quality on selected firms listed on Tehran Stock Exchange over the period 2007-2013. The proposed study uses data envelopment analysis to measure the relative efficiency of selected firms where Sales is considered as output and Cost of goods (COGS, Selling, General and Administrative Expenses (SG&A, Net Property Plant and Equipment (PPE, Net operating Leases (OpsLease, Research & Development (R&D, Purchased Good will (Goodwill and Other intangible assets (OtherIntan are considered as inputs. Earning quality in this survey consists of three parts of quality of accruals, earnings and earnings forecast persistence. The results of our survey have indicated that managerial ability influences positively on earning quality.

  8. Managerial adjustment and its limits: sequential fault in comparative perspective

    Directory of Open Access Journals (Sweden)

    Flávio da Cunha Rezende

    2008-01-01

    Full Text Available This article focuses on explanations for sequential faults in administrative reform. It deals with the limits of managerial adjustment in an approach that attempts to connect theory and empirical data, articulating three levels of analysis. The first level presents comparative evidence of sequential fault within reforms in national governments through a set of indicators geared toward understanding changes in the role of the state. In light of analyses of a representative set of comparative studies on reform implementation, the second analytical level proceeds to identify four typical mechanisms that are present in explanations on managerial adjustment faults. In this way, we seek to configure an explanatory matrix for theories on sequential fault. Next we discuss the experience of management reform in the Brazilian context, conferring special attention on one of the mechanisms that creates fault: the control dilemma. The major hypotheses that guide our article are that reforms lead to sequential fault and that there are at least four causal mechanisms that produce reforms: a transactions costs involved in producing reforms; b performance legacy; c predominance of fiscal adjustment and d the control dilemma. These mechanisms act separately or in concert, and act to decrease chances for a transformation of State managerial patterns. Major evidence that is analyzed in these articles lend consistency to the general argument that reforms have failed in their attempts to reduce public expenses, alter patterns of resource allocation, reduce the labor force and change the role of the State. Our major conclusion is that reforms fail sequentially and managerial adjustment displays considerable limitations, particularly those of a political nature.

  9. JOINT VENTURE: STRATEGY TO OBTAINTHE MANAGERIAL COMPETITIVENESS IN PERU

    OpenAIRE

    Maguiña F., Raúl

    2014-01-01

    This article proposes a managerial competitiveness strategy using the Joint- Venture enterprise, rising out of alliances linking business units, by analizing its making-up process through legal and clear compromise requirements, framed within the peruvian law, and with the purpose of getting feasibility of various investment projects, in any production sector in our country. El artículo propone una estrategia de competitividad empresarial utilizando el joint venture, a partir de alianzas q...

  10. Managerial Methods Based on Analysis, Recommended to a Boarding House

    Directory of Open Access Journals (Sweden)

    Solomia Andreş

    2015-06-01

    Full Text Available The paper presents a few theoretical and practical contributions regarding the implementing of analysis based methods, respectively a SWOT and an economic analysis, from the perspective and the demands of a firm management which functions with profits due to the activity of a boarding house. The two types of managerial methods recommended to the firm offer real and complex information necessary for the knowledge of the firm status and the elaboration of prediction for the maintaining of business viability.

  11. Business annual planning and controlling in Slovenian managerial practice

    OpenAIRE

    Pučko, Danijel; Čater, Tomasž

    2001-01-01

    Management process is usually segmented into planning, organizing, leading and controlling. The first and the last of these subprocesses are analyzed in the paper from the economic and managerial viewpoint as they occurr in Slovenian enterprise practice. The focus is on empirical research on a tactical level. Business analysis, tactical planning and controlling are the core issues analyzed in the article. The paper builds heavily on presenting empirical findings regarding the empirical system...

  12. A MANAGERIAL AND COST ACCOUNTING APPROACH OF CUSTOMER PROFITABILITY ANALYSIS

    OpenAIRE

    PETE Stefan; CARDOS Ildiko Reka

    2010-01-01

    In the last years many organizations realized that market orientation is essential to their success. Satisfying the needs of customers, offering them products and services which meet their desires and demands, customer loyalty can increase profitability for long term. After analyzing the existing journal literature in this field we would like to emphasize that managerial accounting, cost calculation methods and techniques, the analysis of costs provides relevant information when analyzing the...

  13. Managerial Risk Accounting and Control – A German perspective

    OpenAIRE

    Winter, Peter

    2007-01-01

    Recent developments have sparked a renewed interest concerning risk related topics in nonfinancial companies. Risk management issues directly touch the domain of management accounting and control. In Germany, topics related to the support of corporate or enterprise risk management are commonly discussed under the label of “Risikocontrolling”, which will be translated as Managerial Risk Accounting and Control. However, the conceptual foundation of a risk oriented management accounting respecti...

  14. Location as a determinant of accommodation prices: managerial approach

    OpenAIRE

    Napierała, Tomasz; Leśniewska, Katarzyna

    2014-01-01

    In the presentation authors discuss the location-based factors’ impact on accommodation prices. The aim of the presentation is to compare the results of qualitative and quantitative research on location-based determinants of accommodation prices in Lodz Metropolitan Area (Poland). The authors employ methodological triangulation (Yeung 2000), both to explore statistical significance of location-based determinants of accommodation prices, and to present managerial opinions about the influence o...

  15. Capital Structure and Managerial Compensation: The Effects of Renumeration Seniority

    OpenAIRE

    Calcagno, R.; Renneboog, L.D.R.

    2004-01-01

    We show that the relative seniority of debt and managerial compensation has important implications on the design of remuneration contracts.Whereas the traditional literature assumes that debt is senior to remuneration, we show that this is frequently not the case according to bankruptcy regulation and as observed in practice.We theoretically show that including risky debt changes the incentive to provide the manager with stronger performance-related incentives ("contract substitution" effect)...

  16. Personality correlates of Managerial talent: Cross cultural comparison

    Directory of Open Access Journals (Sweden)

    A. D. de Bod

    1983-11-01

    Full Text Available In spite of the worldwide use of the Managerial Assessment Centre, little, if any, cross-cultural research has been done on the method. Another neglected area of AC-research, is the study of personality. This study is aimed at making a contribution towards both these areas by investigating the relationship between the managerial dimensions and personality attributes for a group of Canadian (N = 1199 and a group of South African (N = 177 middle level managers. The first step was to compare the measuring instruments which were used to test the two groups, so as to ascertain any similarities and/or differences between the two instruments. The data which was generated by the application of the instruments was then subjected to a correlational and discriminant function analysis. The result of these analyses was used to (a define the personality correlates of managerial talent and (b to identify broad tendencies with regard to the relative influence of culture on the relationship between personality and managerial talent. Opsomming Ten spyte van die wêreldwye gebruik van die bestuursbeoordelingsentrum (AC is daar tot dusver weinig kruiskulturele navorsing hieroor gedoen. 'n Verdere verwaarloosde area van AC-navorsing, is die bestudering van persoonlikheid. Hierdie studie ondersoek die verwantskap tussen bestuursdimensies en persoonlikheidsattribute van 'n groep Kanadese (N = 1199 en 'n groep Suid-Afrikaanse (N = 177 middelvlakbestuurders. Die eerste stap was om die meetinstrumente wat gebruik is te toets en die twee groepe te vergelyk. Die ingesamelde data vir beide groepe is aan 'n korrelatiewe en diskriminant-funksie ontleding onderwerp. Die ontledings is gebruik om (a die persoonlikheidskorrelate van bestuurstalent te omlyn en (b breë tendense bloot te lê ten opsigte van die relatiewe invloed van kultuur op die verwantskap tussen persoonlikheid en bestuurstalent.

  17. Managers’ Perception on Budget Participation, Procedural Justice and Managerial Performance

    Directory of Open Access Journals (Sweden)

    Sady Mazzioni

    2014-08-01

    Full Text Available The purpose of this paper is analyzing the influence of budget participation on the relationship between procedural justice and managerial performance in organizations in Santa Catarina. In order to achieve the objective, a descriptive quantitative research was carried out, based on a questionnaire, with 5 and 7-pont Likert scale, answered by 44 managers. For data treatment, it was used the statistical package Smart PLS to determine, by regression technique, the contribution of each variable (participation and procedural justice on the dependent variable (performance. Descriptive statistics points to a greater awareness regarding the possibility of participation in budgeting process and a less meaningful feeling regarding superiors’ procedural justice, leaving the assessment of managerial performance in an intermediate condition. Initially, it was found that the correlations between independent (procedural justice and intervening (budget participation variables, and between intervening and dependent (managerial performance variables are statistically meaningful. However, the correlation between independent and dependent variables was not statistically meaningful. The results of using structural equation (path analysis indicated that one of the assumptions of the indirect effect was not confirmed, that is, the relationship between independent and dependent variables should diminish after being controlled by the intervening variable. In the present study, the reverse situation was observed, starting from a non-significant correlation and reaching a significant negative correlation, after the effect of the intervening variable.

  18. Organizational, managerial, and institutional influences on risk management

    International Nuclear Information System (INIS)

    Perin, C.

    1992-01-01

    Organizational and managerial systems for risk management in nuclear power plants are under the influence of externally and internally generated goals. Externally, the NRC, public utility commissions, and such institutions as Institute of Nuclear Power Operations (INPO) establish requirements and guidelines for best practice. Internally, utility strategies define operational goals and standards for safety and production. One managerial responsibility in operating the complex, interdependent technological systems of nuclear power plants is to assure that the activities of departments, divisions, and functions are coordinated. These bridging processes need to be understood in order to suggest alternatives for organizing work and managing risk. To delineate the ways in which regulators and industry institutions affect these processes, details of their influences on daily practices can be addressed through a work system approach. The work system approach takes a dynamic view of organizational structures and managerial processes. Managers balance safety goals with efficiency and production goals through a continuous exchange of information, advice, expertise, budget allocations, personnel, and other resources, drawing on resources from within their organizations and from outside their boundaries. This exchange of resources is essential to organizational strategies for reducing and managing risk

  19. Managerial accounting in the system of payments with enterprise buyers

    Directory of Open Access Journals (Sweden)

    Tsegel'nik N.I.

    2017-12-01

    Full Text Available Today, in the period of global changes in different spheres of social activity, the issue of managerial accounting in the system of payments with buyers is actual enough as the efficiency of management of enterprise economic activity to a great extent depends exactly on the information resources of managerial accounting. The managerial accounting in the system of payments with buyers is adjusted on the implementation of enterprise strategies, that is the construction of administrative accounting depends on the strategy of market scope. There is a necessity to make the decision about how many places for selling products should be opened on a certain geographical territory to satisfy the necessities of present and potential clients of a special purpose group in products, commodities and services. The system of tasks of administrative accounting in the system of payments with buyers is formulated, that allows to unite all the information about the products sold, will do the information integral and will enable users, in particular, the leader of an enterprise, to a great extent to take the opportunity to get the complete information on the state of calculations with buyers and to make administrative decisions correctly in order to avoid complicated and contradictory situations with buyers. The paper determines the directions for further researches in relation to the development of issues, which have direct regard to the buyers of purchase-sale contractual relations.

  20. Work addiction and presenteeism: The buffering role of managerial support.

    Science.gov (United States)

    Mazzetti, Greta; Vignoli, Michela; Schaufeli, Wilmar B; Guglielmi, Dina

    2017-08-08

    The current study examined the mediating effect of presenteeism and moderating effect of managerial support in the relation between workaholism and work-family conflict. A sample of 1065 white-collar employees from an Italian company filled in an online survey and hypotheses were tested using a bootstrapping procedure. Results showed that presenteeism mediated the association between workaholism and work-family conflict. Moreover, the mediating effect of presenteeism was moderated by managerial support: for employees reporting lower levels of support workaholism was stronger related to presenteeism than for those experiencing higher support. Presenteeism, in turn, was related to greater levels of work-family conflict. The present study sheds light into the protective role played by managerial support in preventing workaholic employees from forcing themselves to attend work also when feeling sick. Accordingly, early intervention aimed at buffering the negative association between workaholism and work-family conflict should focus on training managers to develop supportive leadership skills. © 2017 International Union of Psychological Science.

  1. Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.

    Science.gov (United States)

    Pierini, Stefano; Jordanov, Stanislav H; Mitkova, Atanaska V; Chalakov, Ivan J; Melnicharov, Mincho B; Kunev, Kuncho V; Mitev, Vanio I; Kaneva, Radka P; Goranova, Teodora E

    2014-08-01

    Laryngeal squamous cell carcinoma (laryngeal SCC) is a frequently occurring cancer of the head and neck area. Epigenetic changes of tumor-related genes contribute to its genesis and progression. We assessed promoter methylation status of the selected genes (CDKN2A, MGMT, MLH1, and DAPK) using methylation-sensitive high resolution melting (MS-HRM) in 100 patients with laryngeal SCC and studied the correlations with clinical characteristics. The prevalence of promoter methylation in MGMT, CDKN2A, MLH1, and DAPK was 59 of 97 (60.8%), 46 of 97 (47.4%), 45 of 97 (46.4%), and 41 of 97 patients (42.3%), respectively. Significantly increased methylation of CDKN2A was observed in heavy smokers. Epigenetic inactivation of CDKN2A and MLH1 were found to be associated with lymph node involvement. An inverse correlation was present between MLH1 methylation and alcohol consumption. Our results strongly suggest that deregulation of p16-associated, and MLH1-associated pathways, because of promoter hypermethylation, is associated with increased cancer cell migration, tumor invasiveness, and, thus, aggressive phenotype. Copyright © 2013 Wiley Periodicals, Inc.

  2. The Theoretical and Methodical Foundations of Formation and Development of the Managerial Knowledge of Enterprise

    Directory of Open Access Journals (Sweden)

    Denysiuk Olga V.

    2017-05-01

    Full Text Available The article defines the relationship between the concepts of «managerial competency» and «managerial knowledge of enterprise». By generalizing the conceptual provisions, a typology of the enterprise’s competencies has been developed. In order to clarify the contents of the concept of managerial competency, the classification attributes of the managerial knowledge of enterprise have been allocated. The need to use management standards (management of business processes, staff, quality, projects, and production in the processes of formation and development of the managerial competencies of the enterprise has been substantiated. The composition of the methodical support of formation and development of the managerial competencies of enterprise have been provided.

  3. Managerial Ownership in Nursing Homes: Staffing, Quality, and Financial Performance.

    Science.gov (United States)

    Huang, Sean Shenghsiu; Bowblis, John R

    2017-06-20

    Ownership of nursing homes (NHs) has primarily focused broadly on differences between for-profit (FP), nonprofit (NFP), and government-operated facilities. Yet, among FPs, the understanding of detailed ownership structures at individual NHs is rather limited. Particularly, NH administrators may hold significant equity interests in their facilities, leading to heterogeneous financial incentives and NH outcomes. Through the principal-agent theory, this article studies how managerial ownership of individual facilities affects NH outcomes. We use a unique panel dataset of Ohio NHs (2005-2010) to empirically examine the relationship between managerial equity ownership and NH staffing, quality, and financial performance. We identify facility administrators as owner-managers if they have more than 5% of the equity stakes or are relatives of the owners. The statistical analysis is based on the pooled ordinary least squares and NH-fixed effect models. We find that owner-managed NHs are associated with higher nursing staff levels compared to other FP NHs. Surprisingly, despite higher staffing levels, owner-managed NHs are not associated with better quality and we find no statistically significant difference in financial performance between owner-managed and nonowner-managed FP NHs. Our results do not support the principal-agent model and we offer alternative explanations for future research. Our findings provide empirical evidence that NH ownership structures are more nuanced than simply broadly categorizing facilities as FP or NFP, and our results do not fully align with the standard principal-agent model. The role of managerial ownership should be considered in future NH research and policy discussions. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Business development - the function, research propositions, and managerial implications

    DEFF Research Database (Denmark)

    Sørensen, Hans Eibe

    and executives from high-tech firms and venture capitalists in North America, Asia, and Europe to provide a foundation for future research. Business development is an emerging staff function providing an added level of sophistication to the firms' overall strategic management with interesting performance...... implications. The business development function is typically found in progressive firms especially within high-tech industries, but is argued to become critical for all types of firms across industries wishing to grow and accumulate wealth. Research propositions and managerial implications are discussed....

  5. Critical Aspects regarding the Implementation of Managerial Accounting Systems

    Directory of Open Access Journals (Sweden)

    Guinea Flavius-Andrei

    2017-01-01

    This implementation is a genuine organisational revolution that includes the managerial systemused. Any implementation process should take into account the scope of the change in mentalityand culture that the people involved should undergo. The implementation should not be made byimposing hierarchically adopted decisions, but focus on the daily contribution of each andeveryone. A new system which has not been properly internalised and accepted is doomed todisappear. The training effort should be oriented more towards the change of mentality than on thepresentation of the techniques. Within this context, putting the decisions into practice becomesextremely important, especially when it comes to studying the impact on the organisation of theleaders’ attempt to impose their vision.

  6. A MANAGERIAL AND COST ACCOUNTING APPROACH OF CUSTOMER PROFITABILITY ANALYSIS

    Directory of Open Access Journals (Sweden)

    CARDOS Ildiko Reka

    2010-07-01

    Full Text Available In the last years many organizations realized that market orientation is essential to their success. Satisfying the needs of customers, offering them products and services which meet their desires and demands, customer loyalty can increase profitability for long term. After analyzing the existing journal literature in this field we would like to emphasize that managerial accounting, cost calculation methods and techniques, the analysis of costs provides relevant information when analyzing the customer’s profitability. We pay special attention on cost systems. An activity based costing approach takes customer profitability to new levels of accuracy and usefulness, provides the basis for creating, communicating and delivering value to the customers.

  7. The process of managerial control in quality improvement initiatives.

    Science.gov (United States)

    Slovensky, D J; Fottler, M D

    1994-11-01

    The fundamental intent of strategic management is to position an organization with in its market to exploit organizational competencies and strengths to gain competitive advantage. Competitive advantage may be achieved through such strategies as low cost, high quality, or unique services or products. For health care organizations accredited by the Joint Commission on Accreditation of Healthcare Organizations, continually improving both processes and outcomes of organizational performance--quality improvement--in all operational areas of the organization is a mandated strategy. Defining and measuring quality and controlling the quality improvement strategy remain problematic. The article discusses the nature and processes of managerial control, some potential measures of quality, and related information needs.

  8. PSYCHO-SOCIAL PERCEPTIONS AND MANAGERIAL PREFERENCES OF WOMEN ENTREPRENEURS IN WESTERN ROMANIA

    OpenAIRE

    Saveanu Tomina; Borza Adriana

    2010-01-01

    Our study aims at identifying correlations between preferences and psycho-social choices of women entrepreneurs, more precisely the effect of these characteristics on a given managerial strategy. Based on the data obtained through the administration of two types of questionnaires, we analyzed the relations between social and psychological set of perceptions and managerial strategy. Social success and managerial performance are related with these perceptions and thus we can identify a signific...

  9. Quality management techniques in public sector organizations: the role of managerial autonomy and organizational culture

    OpenAIRE

    Demuzere, Sara; Verhoest, Koen; Bouckaert, Geert

    2008-01-01

    According to NPM, more effective and efficient public services can be delivered if public sector organizations are granted more managerial autonomy and if they use various (private sector) management techniques. To date, only very limited attention has been paid to the link between managerial autonomy and the use of management techniques. With this study, we seek to fill this gap in the extensive NPM literature by examining the extent to which managerial autonomy has an effect on the use of m...

  10. The Assistant Manager - a Key Factor of the Managerial Team

    Directory of Open Access Journals (Sweden)

    Lecturer Ph. D. Niculina Vargolici

    2009-05-01

    Full Text Available The new economic context, marked by the crisis and by radical transformations of the labor market, generates the need for more and more sophisticated skills for the assistant manager. That is because the efficiency of the secretarial activity implies both strategic skills and complex abilities, starting from knowledge about the specific activity of the company/institution where the person works as assistant manager, to connected areas such as: management, marketing, human resources, brand communication, company’s culture etc. Whether the manager changes his job together with the “boss”, or the boss is changed and he is bond to adapt to new conditions, a strong team spirit between the manager and his assistant is one of the most important elements that contribute to the productivity and efficiency of the both. The loyalty to the boss and to the company where he works, his adaptation capacity, his competence and his professionalism make the today’s assistant manager a key factor of the managerial team. The essence of the assistant manager job consists in making more efficient the managerial activities, namely, to make it respond to the expectations expressed or not of the manager, or even to anticipate them.

  11. Malaysian aviation technologist promotion to managerial role: an empirical overview

    Science.gov (United States)

    Liew, C. L.; Abu Talib, A. R.; Jacobs, R. L.

    2016-10-01

    The Malaysian aviation industry has continued to march forward. With a turnover of RM23.7 billion in 2013, it is expected to grow higher especially after the Malaysian national aerospace blueprint was launched in 2015. The aviation related organizations currently have a workforce of approximately 13500. These organizations need to be managed by competent managers who have a strong background of technologist. Aviation technologist is one of the key components in the aviation maintenance industry as they are the future managers charged with the responsibility to ensure continuation of the organization's objectives and culture. The technologist role and manager's role are somehow different. The promotion of technologist to managerial roles is quite common but whether the technologist is able to take up managerial role effectively is yet to be fully understood. It is quite common that there was insufficient training for the technologist before being promoted to take up management roles. The purpose of this paper is to give an overview of the role of technologists and managers in professional services industries such as MRO and to understand that there is a need within the industry to re-look into the perspective of a proper training to prepare them to take up management roles effectively.

  12. Managerial Communication in the Context of Organizational Change

    Directory of Open Access Journals (Sweden)

    Mirela Arsith

    2014-05-01

    Full Text Available The hypothesis from which we start in initiating our approach is that according to which managerial communication is an important tool to change an organization's strategy. Our purpose is to argue in favor of the fact that this type of communication contributes significantly to adjusting the attitudes and changing behaviors of the organization members. In the context of change, managerial communication should be transformative, in order to ensure the adaptation of the organization to a new extra-organizational environment, which is, in turn, towards a significant change. What we intend to highlight is the fact that communicative interaction must occur at all levels and to be forceful, visionary and empathetic, to maintain wellness in the organization, as the essential element of the organizational change is the human change. Whatever the type of change - unplanned, planned, imposed, negotiated or participatory – it is very important to harmonize the measures of change between each other and with the processes that normally take place in the organization. Finally, we propose a case study that reveals the role of the transformative leadership and communication in the successful implementation of the new strategy.

  13. Generational shifts in managerial values and the coming of a global business culture

    NARCIS (Netherlands)

    van Hoorn, A.A.J.

    2013-01-01

    In a globalizing world, cross-national differences in values and business culture and understanding these differences become increasingly central to a range of managerial issues. Studies of cultural (dis)similarities in the values of managers (so-called managerial values) and the development of a

  14. Miller Table Company: A Profit Analysis Case Integrating Managerial Accounting, Microeconomics and Marketing

    Science.gov (United States)

    Miller, Louise

    2014-01-01

    This paper describes a unique integrative business case appropriate for use in a managerial accounting course or other business courses related to economics or marketing. The case describes a scenario in which a managerial accountant is assisting in business decisions relating to factors influencing the profitability of a small manufacturing…

  15. A Phenomenological Narrative Study: Elementary Charter School Principals' Managerial Roles

    Science.gov (United States)

    Cetinkaya, Ahmet

    2016-01-01

    This study was a phenomenological narrative research investigating the managerial roles of elementary charter school principals. Managerial leadership practices were investigated under three categories personnel management, student management, and finance management. Elementary charter school principals provided positive feedback for having small…

  16. The Managerial Labor Market and the Governance Role of Shareholder Control Structures in the UK

    NARCIS (Netherlands)

    Renneboog, L.D.R.; Trojanowski, G.

    2002-01-01

    We simultaneously analyze two mechanisms of the managerial labor market: CEO turnover and monetary remuneration schemes.Sample selection models and hazard analyses applied to a random sample of 250 firms listed on the London Stock Exchange over a six-year pre-Cadbury period show that managerial

  17. Managerial Coaches, Are They Ready? The Case of Malaysian Telecommunications Industry

    Science.gov (United States)

    Chong, Chin Wei; Yuen, Yee Yen; Tan, Booi Chen; Zarim, Zainal Abu; Hamid, Norhasniza Abdul

    2016-01-01

    Purpose: This paper aims to identify the key competencies managerial coaches have and examine the significant competencies that affect coaching effectiveness in the Malaysian telecommunications industry. Design/Methodology/Approach: The unit of analysis was individual managerial coaches who were working in the Malaysian telecommunications…

  18. Managerial trust in new product development projects : its antecedents and consequences

    NARCIS (Netherlands)

    Dayan, M.; Benedetto, Di A.C.; Colak, M.

    2009-01-01

    Purpose - To explore managerial trust in new product development (NPD) projects. Design/methodology/approach - Touches on studies into managerial trust, observing few in the articles in the NPD area. Connects trust, interactional justice, management trust and NPD team performance within a conceptual

  19. Managerial competence of first-line nurse managers: A concept analysis.

    Science.gov (United States)

    Gunawan, Joko; Aungsuroch, Yupin

    2017-02-01

    A variety of terms are used interchangeably to define managerial competence of first-line nurse managers. This has resulted in a degree of ambiguity in the way managerial competence is described. The aim of this concept analysis is to clarify what is meant by managerial competence of first-line nurse managers internationally, what attributes signify it, and what its antecedents and consequences are. The Walker and Avant concept analysis approach was applied. The attributes of managerial competence include developing self, planning, organizing, leading, managing legal and ethical issues, and delivering health care. Antecedents to managerial competence include internal and external factors. Consequences include nurse performances, nurse and patient outcomes, intention to stay of nurses, and nurse and patient satisfaction. This analysis helps first-line nurse managers to understand the concept and determine where the responsibility lies in establishing a definition of managerial competence. It is recommended that middle and top managers should be aware of the internal and external factors as antecedents of the concept. Further research is needed to illuminate the attributes of managerial competence in relation to antecedents and the potential effect upon the consequences, and the need to establish managerial competence evaluation. © 2017 John Wiley & Sons Australia, Ltd.

  20. On explaining performance differentials: Marketing and the managerial theory of the firm

    NARCIS (Netherlands)

    Stoelhorst, J.W.; Raaij, van E.M.

    2004-01-01

    Efforts to develop a managerially meaningful alternative to the neoclassical theory of the firm have always been an important part of theory development in marketing. This paper argues that the main explanandum of a managerial theory of the firm is performance differentials between firms. Marketing

  1. On explaining performance differentials: marketing and the managerial theory of the firm

    NARCIS (Netherlands)

    Stoelhorst, J.W.; van Raaij, E.M.

    2004-01-01

    Efforts to develop a managerially meaningful alternative to the neoclassical theory of the firm have always been an important part of theory development in marketing. This paper argues that the main explanandum of a managerial theory of the firm is performance differentials between firms. Marketing

  2. Social Work Discretion between Professionalism and Managerialism in Denmark

    DEFF Research Database (Denmark)

    Skals, Anette

    working with clients who are unfit for work or work market as a result of ill health. In Denmark the local municipal Job Centre is the primary service delivery involved in welfare-to-work. Here values, interest and policies, transformed into rules and regulation, meet the concrete practices of welfare-to-work...... for working in order to helping clients in becoming self-supporting after ill health. As well as examining how social work discretion is made possible in the work organization, the research behind the paper focuses on the issue of new forms of professionalism in social work. In the light of policy changes......Professionalism and managerialism are important and conflicting concepts in the study of professionals working in public service organizations. By focusing on street-level social workers and social work discretion, it is possible to see how welfare-to-work policies are practiced as well as how...

  3. Managerial Long-Term Responsibility in Family-Controlled Firms

    Directory of Open Access Journals (Sweden)

    Dietmar Sternad

    2013-01-01

    Full Text Available Evidence suggests that long-term orientation (LTO as a dominantstrategic logic contributes to the sustainable performance offamily-controlled firms (FCFS. Combining a review of the literatureon lto with stewardship theory and upper echelons theoryreasoning, this article presents a typology of managerial responsibilityand introduces the concept of long-term responsibility as amanagerial characteristic constituting a major driving force behindcreating lto. The antecedents of long-term responsibilityunder family firm-specific conditions (stemming from the familysystem, the governance system, and family-firm managers’ personalcharacteristics are also identified and presented in an integratedmodel. The paper contributes to a more comprehensiveunderstanding of intertemporal choice in fcfs and explains whythey tend to be more long-term oriented than other types of firms.

  4. Epistemic evaluation of the training and managerial competence development process

    Directory of Open Access Journals (Sweden)

    Evelio F. Machado

    2015-12-01

    Full Text Available This article presents the problem of defining the concept of “competence”, due to it being an integral and complex term that has been applied in many domains as well as in a more general sense for everyday life. However, no doubt, a competence can only be tested and valuated in the practice, and it is a person who becomes competent in a context for a certain function. This is why there are many different conceptions in the literature regarding this issue; it’s a consequence of its imprecise, variable character. However, the position profiles (mainly in educational entities and the acceptation/graduation profiles are being more and more frequently established in terms of competences. This paper intends to check what has been valuated and written about the managerial competences training and development regarding the educational field, in order to obtain conclusions regarding its dimension in the school level.

  5. Managerial Ethics: The Ethics in the Enterprise Organizations

    Directory of Open Access Journals (Sweden)

    Roberto Bondarik

    2006-12-01

    Full Text Available The present article has for objective to present the ethics meanings, its application and importance in the enterprise organizations. Century XX was marked by deep transformations in the most diverse fields of the activity human being, also perceived in its finish a concern with the enterprise ethical behavior. Was transferred to charge it of the companies a bigger concern with the quality of its products and the way that these organizations treated its diverse public, the intern and the external one. The ethical behavior in an organization does not have to be to result only of a requirement of the market, but of spontaneous behavior. The importance that the organizations possess in the present time made with that many scholars called our time of Managerial Age, therefore its paradigm is the company, who influences the society.

  6. A MANAGERIAL ACCOUNTING APPROACH OF CUSTOMER RELATIONSHIP MANAGEMENT

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    Ildikó Réka CARDOȘ

    2014-11-01

    Full Text Available Globalization and changes in the business environment have important implications on the nature and function of managerial accounting (MA. Organizations realized that market and customer orientation is essential for their success and the secret to improve profitability and performances is to attract and maintain customers. Customer relationship management (CRM is one of the most important business strategies for organizational performance evaluation. Although CRM is considered to be a marketing topic it is an important MA innovation at the same time and represents an attractive research topic. This article aims to explore the theoretical knowledge of CRM from the perspective of MA. In the first part, we focus on the conceptual framework of CRM, trying to identify processes and technologies involved. The second part is devoted to reflection on the successful implementation of CRM. Finally, we summarize the key points arising from the theory in order to set further research objectives.

  7. [Nursing managerial approach: a study based on general management theories].

    Science.gov (United States)

    Fernandes, Marcia Simoni; Spagnol, Carla Aparecida; Trevizan, Maria Auxiliadora; Hayashida, Miyeko

    2003-01-01

    The purpose of this study was to identify nurses managerial conduct in a private maternity hospital located in the interior of the São Paulo state, Brazil. In order to collect data, authors used a questionnaire with 20 propositions related to the work of nurses in the different units of the hospital. Following, authors performed a descriptive statistical analysis of the data. Results showed a tendency toward democratization in the conduct of the nurses investigated as the majority of the responses privileged questions on team work, workers' participation and group development. Also, authors evidenced that great part of the responses did not agree with the propositions about the principles of the Classical Administration Theory.

  8. Determinants of customer satisfaction with hospitals: a managerial model.

    Science.gov (United States)

    Andaleeb, S S

    1998-01-01

    States that rapid changes in the environment have exerted significant pressures on hospitals to incorporate patient satisfaction in their strategic stance and quest for market share and long-term viability. This study proposes and tests a five-factor model that explains considerable variation in customer satisfaction with hospitals. These factors include communication with patients, competence of the staff, their demeanour, quality of the facilities, and perceived costs; they also represent strategic concepts that managers can address in their bid to remain competitive. A probability sample was selected and a multiple regression model used to test the hypotheses. The results indicate that all five variables were significant in the model and explained 62 per cent of the variation in the dependent variable. Managerial implications of the proposed model are discussed.

  9. Penal managerialism from within: implications for theory and research.

    Science.gov (United States)

    Cheliotis, Leonidas K

    2006-01-01

    Unlike the bulk of penological scholarship dealing with managerialist reforms, this article calls for greater theoretical and research attention to the often pernicious impact of managerialism on criminal justice professionals. Much in an ideal-typical fashion, light is shed on: the reasons why contemporary penal bureaucracies endeavor systematically to strip criminal justice work of its inherently affective nature; the structural forces that ensure control over officials; the processes by which those forces come into effect; and the human consequences of submission to totalitarian bureaucratic milieus. It is suggested that the heavy preoccupation of present-day penality with the predictability and calculability of outcomes entails the atomization of professionals and the dehumanization of their work. This is achieved through a kaleidoscope of direct and indirect mechanisms that naturalize and/or legitimate acquiescence.

  10. Managerial ability and earnings quality: Evidence from Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Hamid Salehi

    2014-07-01

    Full Text Available Auditor independence is associated with the independence of the internal/external auditor from various parties who may have some financial interest in the business being audited. Many countries have set up different rules forcing firms to change their auditors every few years. This helps business retain healthy business. This paper presents an empirical investigation to study the effect of change in auditing system on 90 selected firms from Tehran Stock Exchange over the period 2007-2011. Using a regression model developed earlier by Demerjian et al. (2012a [Demerjian, P. R., Lev, B., Lewis, M. F., & McVay, S. E. (2012a. Managerial ability and earnings quality. The Accounting Review, 88(2, 463-498.], the study determines a positive impact of change in auditor system on business development.

  11. GROWTH OF MANAGERIAL PERFORMANCE BY IMPROVING AUDITING ACTIVITY

    Directory of Open Access Journals (Sweden)

    Daniel DĂNECI-PĂTRĂU

    2014-04-01

    Full Text Available To reflect the place and role of internal audit in the economic entity and its function as assistant manager in this paper we followed the presentation of the preliminary assumptions of a model for measuring the quality of internal audit. Also, we presented a possible model of research regarding managerial effectiveness. Questions that sought answer in this research are: How can we streamline internal audit? What is meant by effective internal audit? What is the relationship between internal audit efficiency and performance management? Recording a high level of performance of internal audit provide a high level of performance of the whole economic entity. Of course, responsible for the implementation of recommendations made by the Internal Auditor is the manager, but in our opinion, as long as the internal audit department conducts activities / tasks with maximum seriousness, conscientiousness and professionalism, the manager will be to some extent forced to implement the recommendations, having a high confidence in those.

  12. A Managerial Approach To A Controversial Exhibition: The Human Body

    Directory of Open Access Journals (Sweden)

    Viorica Aura Păuş

    2013-12-01

    Full Text Available This paper will analyse the reception of the Human Body exhibition of 2013 in Romania, from a managerial point of view. The research is based on the exhibition visitors’ book, to which a content analysis was applied. The main aim of the paper is to investigate how the ‘Grigore Antipa’ Museum (Romania constructed the cultural context in which the scientific arguments prevailed over the religious ones, turning the exhibition of plastinated human bodies into an accepted public event, with a strong emphasis on education and science (medicine. At the same time, ethical concerns and religious criticism were downplayed by maintaining the focus on the ‘education for health’ frame.

  13. Using a Managerial Analogy for Making Mathematics More Attractive

    Directory of Open Access Journals (Sweden)

    Jozef Hvorecký

    2010-06-01

    Full Text Available In many countries, Mathematics is among the least popular school subjects. Educators are spending a lot of time in searching methods that could change this unfortunate situation. The author, a lecturer at a School of Management, discusses the issue as a managerial problem.First, the popularity of mathematics is analyzed as a marketing problem. Marketing theories recommend increasing the market choice as a way of attracting more customers. Our first goal is therefore to expand the variety of problems. To do so, we consider Knowledge Management concepts to demonstrate an imbalance between tacit and explicit knowledge in traditional courses. Currently used educational methodologies favour the latter one. Examples of the approaches that might increase learners’ tacit knowledge are our second goal.

  14. Guidelines for overcoming hospital managerial challenges: a systematic literature review

    Directory of Open Access Journals (Sweden)

    Crema M

    2013-10-01

    Full Text Available Maria Crema, Chiara Verbano Department of Management and Engineering, University of Padova, Vicenza, Italy Purpose: The need to respond to accreditation institutes' and patients' requirements and to align health care results with increased medical knowledge is focusing greater attention on quality in health care. Different tools and techniques have been adopted to measure and manage quality, but clinical errors are still too numerous, suggesting that traditional quality improvement systems are unable to deal appropriately with hospital challenges. The purpose of this paper is to grasp the current tools, practices, and guidelines adopted in health care to improve quality and patient safety and create a base for future research on this young subject. Methods: A systematic literature review was carried out. A search of academic databases, including papers that focus not only on lean management, but also on clinical errors and risk reduction, yielded 47 papers. The general characteristics of the selected papers were analyzed, and a content analysis was conducted. Results: A variety of managerial techniques, tools, and practices are being adopted in health care, and traditional methodologies have to be integrated with the latest ones in order to reduce errors and ensure high quality and patient safety. As it has been demonstrated, these tools are useful not only for achieving efficiency objectives, but also for providing higher quality and patient safety. Critical indications and guidelines for successful implementation of new health managerial methodologies are provided and synthesized in an operative scheme useful for extending and deepening knowledge of these issues with further studies. Conclusion: This research contributes to introducing a new theme in health care literature regarding the development of successful projects with both clinical risk management and health lean management objectives, and should address solutions for improving health

  15. Informative-syntanalitical support system of managerial decision-making

    Directory of Open Access Journals (Sweden)

    O.M. Kostenko

    2017-12-01

    Full Text Available The article discusses the theoretical and methodological positions in the formation of info-syntanalitical management providing service. The author determines the directions in the improvement of the info-accounting formalization within the social phenomena and processes due to using there the info-syntanalitical identification. The management process, which is essentially the exchange of information between the management object and the management system, is examined. It is proved the necessity of the information, which should be objective, reliable, understandable, completed and useful for making or amending managerial decisions. The information sources used for decision-making are explored. It is determined that they serve as statistical observation, accounting and various off-classified data that characterize market and climatic conditions, regulatory environment, political stability, investment climate, etc. It is argued that the basis of the service activity is the staff, methods and conditions of service, while the effectiveness of the service depends on the correct management activity, which is provided by informative needs at different levels carried out with the help of information-syntactical service. The necessity of research was emphasized as the triad consisting of information, analytics and service, the task of which is to use existing information, to identify the reasons of process (situation undesirable development and to synthesize the results of the analytical assessment, to determine the reasonable directions of solving problem and in the most appropriate form to convey the possible options of managerial decisions to users, i.e. to create a high-quality service. It is generalized that the essence of the info-syntalitical service is expressed through the improvement of management efficiency by the improving display of in-depth reflection and reasonable prediction of the developing management object, as well as increasing the

  16. Investment, managerial capacity, and bias in public health preparedness.

    Science.gov (United States)

    Langabeer, James R; DelliFraine, Jami L; Tyson, Sandra; Emert, Jamie M; Herbold, John

    2009-01-01

    Nearly $7 billion has been invested through national cooperative funding since 2002 to strengthen state and local response capacity. Yet, very little outcome evidence exists to analyze funding effectiveness. The objective of this research is to analyze the relationship between investment (funding) and capacity (readiness) for public health preparedness (PHP). The aim of the authors is to use a management framework to evaluate capacity, and to explore the "immediacy bias" impact on investment stability. This study employs a longitudinal study design, incorporating survey research of the entire population of 68 health departments in the state of Texas. The authors assessed the investment-capacity relationship through several statistical methods. The authors created a structural measure of managerial capacity through principal components analysis, factorizing 10 independent variables and augment this with a perceived readiness level reported from PHP managers. The authors then employ analysis of variance, correlation analyses, and other descriptive statistics. There has been a 539 percent coefficient of variation in funding at the local level between the years 2004 and 2008, and a 63 percent reduction in total resources since the peak of funding, using paired sample data. Results suggest that investment is positively associated with readiness and managerial capacity in local health departments. The authors also find that investment was related to greater community collaboration, higher adoption of Incident Command System (ICS) structure, and more frequent operational drills and exercises. Greater investment is associated with higher levels of capacity and readiness. The authors conclude from this that investment should be stabilized and continued, and not be influenced by historical cognitive biases.

  17. MANAGERIAL PROBLEMS CONFRONTED BY EXECUTIVE CHEFS IN HOTELS

    Directory of Open Access Journals (Sweden)

    Kemal BIRDIR

    2014-07-01

    Full Text Available The study was conducted to determine the managerial problems confronted by executive chefs working at 4 and 5-star hotels in Turkey. A survey developed by the researchers was employed as a data collection tool. Answers given by participants were analyzed using “T-test” and “ANOVA” analyses in order to determine whether there are significant differences of opinion on the subject (collated in answers to the survey questionnaire amongst executive chefs, based on answers given by them (expressed as average figures dependent upon such variables as their “Age”, “Gender”, “Educational Status” and “Star status of the hotel within which they worked.” The study results showed that the most important problem confronting executive chefs was “finding educated/trained kitchen personnel.” On the specific problem, “responsibility and authority is not clear within the kitchen,” there was a significant difference of opinion by the gender of the executive chefs. Moreover, there was a significant difference of opinion dependent upon the star status of the hotels within which the chefs worked on the problem of whether or not “the working hours of kitchen personnel were too long.” The findings suggest that there are important problems confronted by executive chefs. Moreover, male and female executive chefs have different opinions on the magnitudes of some specific problems. Whereas there are various reports and similar publications discussing problems faced by executive chefs, the present study is the first one in the literature that solely explore the managerial problems experienced at a kitchen context.

  18. 41 CFR 102-192.125 - What is the appropriate managerial level for an agency mail manager?

    Science.gov (United States)

    2010-07-01

    ... managerial level for an agency mail manager? 102-192.125 Section 102-192.125 Public Contracts and Property... ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Agency Mail Manager Requirements § 102-192.125 What is the appropriate managerial level for an agency mail manager? The agency mail manager should be at a managerial...

  19. Managerial Stress Management as an Asset in People Management Being a Marketing Strategy Element

    Directory of Open Access Journals (Sweden)

    Branislav Radnović

    2013-07-01

    Full Text Available Any service organization operating under turbulent market conditions must have a successful marketing strategy. A successful marketing strategy implies proper management of all elements within a marketing mix: service package, price, distribution channels, promotion, service process, service ambience and people. People, i.e. primarily the employed within an organization are one of the elements that must be appropriately considered when drawing up and implementing a marketing strategy. Proper personnel management must nowadays include good management of managerial stress. Adequate managerial stress management is preconditioned by successful identification of sources of managerial stress. The aim of this paper is to present the importance of proper and timely identification of sources of managerial stress. The paper demonstrates the carried out scientific research based on a method that is universal for all types of organizations, regardless of their type and activity, in order to precisely identify the sources of managerial stress and define its proper management, as an asset in people management, which is an element of marketing strategy. The research was conducted using a survey, sampling 100 employees in 13 organizations throughout Serbia. Survey results indicated that the most important sources of managerial stress are: participation in decision-making, selection process, earnings, and time and deadlines pressure. Therefore, recommendations are provided for directing identified sources of managerial stress towards successful management of people as an element of marketing strategy.

  20. Deactivation of Pacemaker: Ethical Approach or Managerial Failure?

    Directory of Open Access Journals (Sweden)

    Macková Marie

    2017-12-01

    Full Text Available The decision about the deactivation of a pacemaker must be the result of a multicriteria decision-making process where the legal, ethical and effectiveness aspects must be taken into account and delicately balanced, while also considering the risk of managerial failure. Academic as well as professional discussion is necessary because there is a whole range of question marks on this topic and all the aspects mentioned above. The aim of this paper is to contribute to the debate by presenting the views of Czech physicians about the possibility of deactivation of the pacemaker in patients in terminal states. Based on the results of our research, the following steps are recommended to enable the deactivation of pacemakers in the Czech environment. Before the patient’s own indication of pacemaker therapy, treatment should be discussed with the patient in detail, including complications and deactivation options. Czech ethical consultant services should be set up in Czech hospitals. And last but not least, they should take an opinion on this issue as well as the professional society.

  1. Managerial Strategies for the Conservation of Rurality in Rural Tourism

    Directory of Open Access Journals (Sweden)

    Cornelia Petroman

    2010-10-01

    Full Text Available If we admit that rurality designates small densities, open areas, small settlements below 1,000 inhabitants, and land reserved mainly to agricultural and forestry practices, and as natural area, if we admit that society tends to be traditional and that government al policies tend to conserve rather than to make rapid or radical changes, then we should admit that rural tourism should be an activity generating new incomes in the area. Rurality also means preserving a continuum in the approach of different types of areas with different characteristics, a concept that can also be of use in the identification of activities specific to rural tourism. Be they activities specific to the rural environment or activities common to the rural area, they need to aim at the conservation of rurality as a main tourism resource. Managerial strategies in rural tourism contribute effectively to rural development, provided they are sustainable and that rural tourism be not the only solution for rural development.

  2. Managerial strategies to make incentives meaningful and motivating.

    Science.gov (United States)

    Korlén, Sara; Essén, Anna; Lindgren, Peter; Amer-Wahlin, Isis; von Thiele Schwarz, Ulrica

    2017-04-10

    Purpose Policy makers are applying market-inspired competition and financial incentives to drive efficiency in healthcare. However, a lack of knowledge exists about the process whereby incentives are filtered through organizations to influence staff motivation, and the key role of managers is often overlooked. The purpose of this paper is to explore the strategies managers use as intermediaries between financial incentives and the individual motivation of staff. The authors use empirical data from a local case in Swedish specialized care. Design/methodology/approach The authors conducted an exploratory qualitative case study of a patient-choice reform, including financial incentives, in specialized orthopedics in Sweden. In total, 17 interviews were conducted with professionals in managerial positions, representing six healthcare providers. A hypo-deductive, thematic approach was used to analyze the data. Findings The results show that managers applied alignment strategies to make the incentive model motivating for staff. The managers' strategies are characterized by attempts to align external rewards with professional values based on their contextual and practical knowledge. Managers occasionally overruled the financial logic of the model to safeguard patient needs and expressed an interest in having a closer dialogue with policy makers about improvements. Originality/value Externally imposed incentives do not automatically motivate healthcare staff. Managers in healthcare play key roles as intermediaries by aligning external rewards with professional values. Managers' multiple perspectives on healthcare practices and professional culture can also be utilized to improve policy and as a source of knowledge in partnership with policy makers.

  3. MANAGERIAL ORGANISATIONAL PATHOLOGIES IN PERIODS OF EXETENDED CRISIS

    Directory of Open Access Journals (Sweden)

    PASTOR IOAN

    2014-08-01

    Full Text Available In periods of extended crisis an increasing number of organisations are faced and confronted with pathological phenomena such as corruption, organizational stress, burnout, workaholism, mobbing, collective personality, organizational myths and neurotic organizations, which can generate organisational dysfunctions, managerial and organisational crises, critical moments when the results are unclear, disorders, confusions, mental and professional illnesses, organisational illnesses. All these have severe and generalized disadaptive effects that influence not only the personal life of the organisation’s members, but also their socio-professional life. They affect the work ability of the members of the organisation, the formal and informal relationships between them, their well-being and work productivity. In time, the organisation turns from a healthy and efficient one into a morbid and very unproductive one. The paper presents the results of some research for diagnosing some of these disadaptive phenomena present in the different sectors of activity of the Mureş County, which are affected by an extended crisis: organisational stress, burnout, workaholism and mobbing.

  4. R&D tax incentives for innovation and managerial decisions

    Directory of Open Access Journals (Sweden)

    Monika Walicka

    2016-09-01

    Full Text Available In many countries tax incentives are a popular means of realizing political, economic and social objectives. The main motive of their application is often to achieve and accelerate the selected activities in the public interest and also stimulate development of industry, and induce growth in research and investment. The key element that helps a company achieve a competitive advantage is innovation. Global competition forces the production of unique products and services. Tax incentives in science, research and development are important in stimulating innovation. The purpose of this article is to show the level of managerial awareness about R&D tax incentives, the level of R&D tax incentive usage by companies in Poland, and main obstacles that managers meet with R&D tax incentives in practice. We explore R&D tax incentives as a government instrument on R&D management and aim to find the reasons why Polish companies do not take advantage of them. We examine 275 companies using a semi-structured questi onnaire. Our findings suggest that many firms report lack of knowledge about such incentives, and firms find many obstacles to reach all of the requirements which are necessary to use the incentive. Due to our analysis we find that large firms, especially those that implement innovation, are more likely to use the tax incentives, but small and medium sized companies find more obstacle. The effect of this tax policy is significant mainly in large, high-tech sector firms.

  5. Managerial instrument for didactic staff structure optimization for Distance Learning

    Directory of Open Access Journals (Sweden)

    Gavrus Cristina

    2017-01-01

    Full Text Available Distance learning is a modern system for providing educational services and is relatively new in Romania, if related to the date of its emergence in Europe. More and more active working people are interested in this form of education, paying of course a special attention to its quality. It is quite difficult to appraise the quality of educational programs but several instruments and criteria have been developed over time. The present paper proposes an original mathematical instrument that is aiming at human resources, this type of resources being considered extremely important in case of providing educational service. The number of teachers is crucial for a distance learning program study, because the didactic staff must cover a number of didactic classes that take place on weekends. Concretely, this paper is focused on finding an algorithm that allows the didactic staff structure optimization. For accomplishing this objective, two managerial instruments were use. One of them is mathematical linear programing technique, that develops a mathematical model for didactic staff structure and the other one is WinQSB software package that tests the mathematical model.

  6. Conditions of Forming of Managerial Competences of the Enterprise

    OpenAIRE

    Denisyuk Olga V.

    2012-01-01

    The article analyzes the involvement of industrial enterprises in innovation, the tendency of managers to implement innovations. The conditions of formation of managerial competences are defined by means of laying the emphasis on financial, investment, industrial, and educational and qualification factors.В статье проанализирована степень участия промышленных предприятий в инновационной деятельности, склонность управленцев к внедрению нововведений. Определены условия формирования управленческ...

  7. Accomplishing Water Strategy Policies in Hospitals: The Role of Management Information Systems and Managerial Styles

    Directory of Open Access Journals (Sweden)

    David Naranjo-Gil

    2017-02-01

    Full Text Available Hospitals are using more sophisticated and comprehensive management information systems to implement multiple strategic policies towards water cost saving and water quality enhancement. However, they do not always achieve the intended strategic goals. This paper analyzes how managerial styles interact with sophisticated management information systems to achieve different water strategic priorities. How proactive vs. reactive managerial styles moderate the effects of management information systems on water cost saving and water quality enhancement is analyzed. Relationships are explored using data collected from 122 general services directors in Spanish public hospitals. The findings show a positive effect of sophisticated management information systems on the achievement of water policies focused on cost saving and quality enhancement. Results also show a different moderated effect of managerial styles; thus, sophisticated management information systems with a proactive managerial style facilitate managers to achieve better water quality policies rather than water cost saving policies.

  8. Integrating Computer Spreadsheet Modeling into a Microeconomics Curriculum: Principles to Managerial.

    Science.gov (United States)

    Clark, Joy L.; Hegji, Charles E.

    1997-01-01

    Notes that using spreadsheets to teach microeconomics principles enables learning by doing in the exploration of basic concepts. Introduction of increasingly complex topics leads to exploration of theory and managerial decision making. (SK)

  9. Managerialism, organisational commitment, and quality of job performances among European university employees

    NARCIS (Netherlands)

    Smeenk, S.; Teelken, J.C.; Doorewaard, H.; Eisinga, R.

    2009-01-01

    To achieve efficient and effective quality improvement, European universities have gradually adopted organizational strategies, structures, technologies, management instruments, and values that are commonly found in the private business sector. Whereas some studies have shown that such managerialism

  10. Managerialism, Organizational Commitment, and Quality of Job Performances among European University Employees

    NARCIS (Netherlands)

    Smeenk, S.G.A.; Teelken, J.C.; Eisinga, R.N.; Doorewaard, J.A.C.M.

    2009-01-01

    To achieve efficient and effective quality improvement, European universities have gradually adopted organizational strategies, structures, technologies, management instruments, and values that are commonly found in the private business sector. Whereas some studies have shown that such managerialism

  11. Managerialism, organizational commitment and quality of job performances among European university employees

    NARCIS (Netherlands)

    Smeenk, S.; Teelken, Ch.; Eisinga, R.; Doorewaard, R.

    2009-01-01

    To achieve efficient and effective quality improvement, European universities have gradually adopted organizational strategies, structures, technologies, management instruments, and values that are commonly found in the private business sector. Whereas some studies have shown that such managerialism

  12. Managerial conflict management in five European countries : The importance of power distance, uncertainty avoidance, and masculinity

    NARCIS (Netherlands)

    Van Oudenhoven, J.P.; Mechelse, L.; De Dreu, C.K.W.

    This research deals with managerial conflict management in Denmark, United Kingdom, The Netherlands, Spain, and Belgium. According to Hofstede (1991). these countries' cultures differ primarily in terms of uncertainty avoidance, power distance, and masculinity-femininity. The differences in

  13. Managerial performance and cost efficiency of Japanese local public hospitals: a latent class stochastic frontier model.

    Science.gov (United States)

    Besstremyannaya, Galina

    2011-09-01

    The paper explores the link between managerial performance and cost efficiency of 617 Japanese general local public hospitals in 1999-2007. Treating managerial performance as unobservable heterogeneity, the paper employs a panel data stochastic cost frontier model with latent classes. Financial parameters associated with better managerial performance are found to be positively significant in explaining the probability of belonging to the more efficient latent class. The analysis of latent class membership was consistent with the conjecture that unobservable technological heterogeneity reflected in the existence of the latent classes is related to managerial performance. The findings may support the cause for raising efficiency of Japanese local public hospitals by enhancing the quality of management. Copyright © 2011 John Wiley & Sons, Ltd.

  14. [The construction process of managerial profile competencies for nurse coordinators in the hospital field].

    Science.gov (United States)

    Manenti, Simone Alexandra; Ciampone, Maria Helena Trench; Mira, Vera Lucia; Minami, Lígia Fumiko; Soares, Jaqueline Maria Sousa

    2012-06-01

    The objective of this study was to construct a profile of managerial competencies, based on the consensus of nurse coordinators in the field. This study was developed in a philanthropic hospital in São Paulo, following the research-action model, and included 13 nurse coordinators as participants. The data collection was performed using the focal group technique. Data analysis was performed using the theoretical frameworks related to the working process and managerial competencies. The results identified the greater emphasis assigned to the competencies related to the mentor, coordinator and director roles. It was, therefore, possible to construct a professional development plan that is based on competencies in the technical, ethical-political, and communicative domains, as well as the development of citizenship. The analysis of the managerial working process and the study of the competencies within the managerial environment were shown to be important, because they highlighted the professionals' need to improve, thus fulfilling personal, professional, and organizational demands.

  15. Abordarea managerială în studiul administrației publice (II

    Directory of Open Access Journals (Sweden)

    Cristina MORA

    2002-06-01

    Full Text Available Current paper analyzes in the first part the causes of the decreased interest towards scientific management, accepting although its virtues as starting point for a managerial approach in public administration. This paper also points out that the bureaucratic model that has been presented previously does not match with the process of organizing public administration where a change in managerial terms is absolutely necessary.

  16. Managerial Analysis Regarding the Strategic Premises of Two Large Tourism Agencies

    Directory of Open Access Journals (Sweden)

    Solomia Andres

    2016-06-01

    Full Text Available The paper presents some theoretical and practical ideas regarding the application of managerial analysis methods of strategic premises belonging to two large tourism agencies that presently function on profitable bases on the Caras-Severin county territory. The observation refers to the managerial analysis used, which offers the information necessary to obtaining knowledge on the status of the firm and on the establishment of relevant premises and proposals for the viability of business in the tourism domain.

  17. Small Firms in a Small Country: Managerial Factors, Internationalization and Performance of Slovenian SMEs

    OpenAIRE

    Mariola Ciszewska-Mlinarič; Franjo Mlinarič

    2010-01-01

    International activities of small and medium enterprises (SMEs) constitute an important research area. To understand this phenomenon, researchers employ different theoretical perspectives. Among them, the resource-based theory has been given much attention. In this study three managerial factors: managerial attitude toward internationalization, internationalization knowledge and international experience, are seen as examples of the firm’s intangible assets. The objectives of this study are tw...

  18. INTERDEPENDENT ANALYSIS OF LEVERAGE, DIVIDEND, AND MANAGERIAL OWNERSHIP POLICIES: Agencies Perspectives

    Directory of Open Access Journals (Sweden)

    Wibisono Hardjopranoto

    2006-06-01

    Full Text Available This paper attempts to investigate interdependent mechanism among leverage, dividend, and managerial ownership policies. This paper considers firm size and economic conditions to control their effect on the relationship among the three policies. The interrelationship between leverage, dividend, and managerial ownership policies will be tested using two-stage least squares. Five exogenous variables are employed in simultaneous equation: current assets and structure of assets as leverage determinants, book to market and return on investment as dividend determinants, and relative return to risk as managerial ownership determinant. The research employs year 1994-2004 data, with 1717 firm years. The research findings can be summarised as follows. First, there is a negative relationship between managerial ownership and leverage policies as suggested by agency theory. Second, there is a relationship between managerial ownership and dividend policies, but the relationship between leverage and dividend is insignificant. Third, the relationship between leverage and dividend is insensitive to economic condition and firm size. Fourth, all exogenous variables have significant effect on endogenous variables, except relative return. Fifth, the effects of exogenous variables are not sensitive to control variables. Sixth, we find that managers show self-interest behaviours by reducing managerial ownership when the economic condition worsens.

  19. Factors contributing to managerial competence of first-line nurse managers: A systematic review.

    Science.gov (United States)

    Gunawan, Joko; Aungsuroch, Yupin; Fisher, Mary L

    2018-02-01

    To determine the factors contributing to managerial competence of first-line nurse managers. Understanding factors affecting managerial competence of nurse managers remains important to increase the performance of organizations; however, there is sparse research examining factors that influence managerial competence of first-line nurse managers. Systematic review. The search strategy was conducted from April to July 2017 that included 6 electronic databases: Science Direct, PROQUEST Dissertations and Theses, MEDLINE, CINAHL, EMBASE, and Google Scholar for the years 2000 to 2017 with full text in English. Quantitative and qualitative research papers that examined relationships among managerial competence and antecedent factors were included. Quality assessment, data extractions, and analysis were completed on all included studies. Content analysis was used to categorize factors into themes. Eighteen influencing factors were examined and categorized into 3 themes-organizational factors, characteristics and personality traits of individual managers, and role factors. Findings suggest that managerial competence of first-line nurse managers is multifactorial. Further research is needed to develop strategies to develop managerial competence of first-line nurse managers. © 2017 John Wiley & Sons Australia, Ltd.

  20. Managerial overconfidence and debt maturity structure of firms Analysis based on China's listed companies

    Institute of Scientific and Technical Information of China (English)

    Jiang Wei; Xiao Min; You Jiaxing

    2011-01-01

    Purpose-The purpose of this paper is to empirically analyze the effects of managerial overconfidence on debt maturity structure decisions in terms of liquidity risk and asset match in Chinese listed companies.Design/methodology/approach-Combining data from CSMAR with some default data collected by hand,this paper selects age,tenure,education,education background and whether the board chair and CEO positions are consolidated in Chinese listed companies as proxies of managerial overconfidence.Thus,the authors acquired needed and credible empirical data.Findings-It was found that,the younger the CEO,the shorter the tenure,the lower the education,having economics or management education and being chairman concurrently,CEOs have stronger managerial overconfidence.Thus,corporate debt maturity structure is more weakly correlated with debt ratio and asset structure.Research limitations/implications-The findings in this study suggest that managerial irrationality,especially overconfidence,does have an effect on the financing decisions of firms.Originality/value-This is the first paper to analyze the effects of managerial overconfidence on debt maturity structure derisions in terms of liquidity risk and asset match.The findings inspire firm risk management policies from managerial overconfidence.

  1. Managerial ownership and corporate performance in Slovenian post-privatisation period

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    Marko Simoneti

    2004-12-01

    Full Text Available The Slovenian post-privatisation period has been characterised by a decline in the ownership by non-managerial owners (employees and state-controlled funds. On the other hand, domestic and foreign non-financial firms, Privatisation Investment Funds and managers have been increasing their holdings. The latter, namely the growing managerial ownership, is likely to feature in future ownership dynamics in Slovenia. In fact, in 2002 the desired (optimal ownership stakes estimated by Slovenian managers were 10.8 percentage points higher than their actual stakes. The aim of our paper is to describe the main trends in the ownership of Slovenian corporations in the post-privatisation period and to provide an answer to the basic economic question: what is the influence of the ongoing consolidation of managerial ownership on the performance of Slovenian firms. The empirical analysis testing this relationship is based on a panel of 182 Slovenian firms in the 1995-99 period and does not provide relevant evidence of any positive effects of the increasing managerial control on Slovenian firms’ performance. If any, a positive incentive effect is only observed in those firms whose managers’ holdings exceed 10-percent, only with regards to firms’ financial performance (but not total factor productivity and only in firms that are not listed on the capital market. Further, the negative effect of the current gap between the desired and actual managerial ownership seems to exceed any positive incentive effect arising out of managerial ownership

  2. Educational technologies in the system of managerial staff mentoring

    Directory of Open Access Journals (Sweden)

    L. P. Gancharik

    2016-01-01

    Full Text Available Investigations related to educational technologies, ensuring the Investigations are related to the educational technologies, ensuring the formation and support of a system of mentoring of managerial staff on the basis of the «cascade» technology training. A new form of cascade training – academic cascade training when the educational institutions create a large-scale information and educational environment on the basis of telecommunication technologies to provide the institute mentoring support in the state bodies and organizations.In comparison with the traditional mentoring (personal experience, students and graduates of the retraining system of educational institutions can transmit the knowledge and skills, acquired by them in the course of training, to the young managers and specialists of their organizations, thereby promoting further innovative educational potential of educational institutions through a system of cascading mentoring. For this purpose, in educational institutions an interactive educational environment is created based on telecommunication technologies, which allows you to create and develop a common information space, to simplify the procedure for communicating the mentors and trainees, to provide a wide access to the content. Telecommunication information technologies are not only a powerful tool, intelligent instrument and means of creating a cascade learning environment, but also an important factor in improving the entire methodical system of mentoring.It is proposed the creation of a large-scale information and educational environment on the basis of telecommunication technologies for cascade training when the educational institutions may become a part of the mentoring institution. On the one hand, they prepare students, including both potential mentors, and on the other hand, using modern telecommunication educational technologies, they participate together with the students-mentors in mentoring activity in

  3. From feeling to naming: A sensitive approach to managerial newspeak through bullying at work

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    Agnès Vandevelde-Rougale

    2016-02-01

    Full Text Available By accessing language, an individual is granted the means to represent experiences and to share meaning. However, ill-being resulting from workplace bullying makes it hard for the subject to put his/her experience into words. I explored this uneasiness through qualitative research conducted through an interdisciplinary approach. My fieldwork led me to raise questions about the influence of modern managerial discourse on the individual and his/her relation to language. After conducting in-depth interviews with individuals confronted with bullying at work and crossing their narratives with information from organisational websites, I suggest that modern managerial discourse hinders the expression of emotions and thereby the understanding of subjective experiences (both the informants’ understanding of their own subjective experience and the understanding of their experiences by others. I argue that this process is rooted in an internalization of managerial discourse, which weakens the subject as it diminishes his/ her enunciative autonomy and limits his/her ability to make sense of his/her emotional experiences. This article considers these findings. Through excerpts from organisational communications, the first part calls on the heuristic dimension of knowing via the senses to question the subjective influence of managerial discourse. The narrative of an experience of workplace bullying then allows for display of the ambivalence of managerial discourse. It appears to be a tool both enabling and hindering subjective expression, as it allows sharing of facts at the expense of sharing emotions. Considering my argument that the internalization of managerial discourse by the subject turns this discourse into “managerial newspeak”, the third and concluding part of the article addresses the issue of sharing understanding of psychosocial processes in scientific work.

  4. Environmental impacts assessment of industrial estate providing with managerial process

    Energy Technology Data Exchange (ETDEWEB)

    Nouri, J.; Mahvi, A.H.; Younesian, M.; Nabizadeh, R.; Hashemi, I. [Univ. of Tehran (Iran)

    2007-07-01

    The existence of balance, coordination and required order among natural elements is one of the key factors in the ecosystem. If this balance is disturbed under certain circumstances, it will damage the structure of living existences and more specifically human beings. Since a half century ago, factors such as important economical and industrial activites, advanced technologies together with growing population and lack of concordance among different couhntries to take optimal advantage of the existing natural resources have distrubed the balance in the ecosystem. As a result, man has caused many problems such as high death tolls and arduous diseases due to the different pollutions in water, air, land, sound, temperature, etc and factors such as erosion, desert, expansion, floods, extinction of plant and animal species, ozone layer destruction, global warming, sea level rise and greenhouse gases increase. Environmental Impact Assessment (EIA) is to recognize and assess systematic consequences of projects and programs on elements like physicochemical, biological, cultural, economical and social phenomena in th environment; in other words it is a way or method to determine the direction of predication and assessment of environmental impacts of activities on the environmental health of the ecosystem affecting human lives. In this study, and environmental impact assessment of the establishment of the Shahzand Industrial Estate in Arak at the central part of Iran was investigated. After collection of data and analysis of the findings, the positive and negative impacts resulting from establishment of the indutrial estate were investigated using the Leopold Matrix and Scaling checklist methods providing the managerial solutions in order to minimize the harmful environmental impacts. The existing environmental situation was investigated and then environmental impact alternatives were determined. This was done in regard to the amount and kind of predicted pollution for the

  5. Do Short-Term Managerial Objectives Lead to Under- or Over-Investment in Long-Term Projects

    OpenAIRE

    Lucian Arye Bebchuk; Lars A. Stole

    1994-01-01

    This paper studies managerial decisions about investment in long-run projects in the presence of imperfect information (the market knows less about such investments than the firm's managers) and short-term managerial objectives (the managers are concerned about the short-term stock price as well as the long-term stock price). Prior work has suggested that imperfect information and short-term managerial objectives induce managers to underinvest in long-run projects. We show that either underin...

  6. The Effects of Tight Budgetary Control on Managerial Bahaviour in the Swedish Public Sector : Emphasizing Motivation, Commitment, Satisfaction and Stress

    OpenAIRE

    Hemsing, Malte; Baker, Fadi

    2013-01-01

    This thesis study is about the effects of tight budgetary control on managerial behaviour in the Swedish public sector. Managerial behaviour represents the four variables; motivation, organizational commitment, stress, and satisfaction. As previous research mostly investigated the effects of tight budgetary control on organizational performance in the private sector, this study can be seen as one of the first that focus on managerial behaviour and is based on the public sector. For the data c...

  7. The Effect of Managerial Ability on Future Stock Price Crash Risk: Evidence from Korea

    Directory of Open Access Journals (Sweden)

    Soo Yeon Park

    2017-12-01

    Full Text Available This study examines the effect of managerial ability on subsequent stock price crash risk using listed firm data in Korea. Compared to some financially advanced countries, the influence of managers is particularly more powerful in Korea, as ownership and management are not effectively separate in most Korean firms. In addition, we considered the effect of large business groups called Chaebol, which is family-run conglomerates with unique corporate governance system that hugely affect the Korean economy. It is important to recognize determinants of the stock price crash risk which would result in doubt on going concern to enhance the company’s sustainable management. Hence, this study focuses on the managerial ability as one of the main factors of the stock price crash risk. We use the measures of firm-specific stock price crash risk based on Hutton et al. (2009. Managerial ability is estimated through a Data Envelopment Analysis (DEA and tobit regressions following Demerjian et al. (2012. From the empirical tests, there is a negative association between managerial ability and stock price crash risk. This suggests that managers with a higher ability release more voluntary disclosure to signal their ability, ultimately lowering the subsequent stock price crash risk. We also find that firms in large business groups, Chaebol, weaken the negative association between managerial ability and subsequent stock price crash risk.

  8. Leadership styles and managerial culture at industrial enterprises with different modernization and innovation processes

    Directory of Open Access Journals (Sweden)

    Glukhov Sergei

    2017-01-01

    Full Text Available The article presents the results of an empirical research into the transformational leadership and managerial culture at industrial enterprises with different modernization and innovation processes. The authors suggest the criteria for differentiation of options of making changes at the industrial companies: the attitude to their own research base, the focus on introduction of innovations, the investment potential for the introduction of innovations, contacts with research and educational agencies, presence of institutional innovation structures in the structure. It was found out that the managerial profile of an industrial enterprise, focused on innovation activities, involves the index of transformational leadership and the managerial culture with a subject-oriented management, i.e. democratic, which is manifested in the commitment to the group decision making process; humanizing, which is manifested in the attitude towards the employees as being independently valuable regardless the context of achieving organizational results; and innovative, which is manifested in the constant quest for changes.

  9. MANAGERIAL OPTIMISM AND DEBT FINANCING: CASE STUDY ON INDONESIA MANUFACTURING LISTED FIRMS

    Directory of Open Access Journals (Sweden)

    Gesti Memarista

    2016-10-01

    Full Text Available Managerial’s psychology can affect financial decision in the company. This paper analyzes the influence of managerial optimism on the debt financing by using regression analysis. The dependent variable in this paper is debt financing. The independent variable is managerial optimism and the control variable are firm value, firm size, and firm performance that are occurred in the previous period. The sample used in this study is manufacturing companies that listed in Indonesian stock exchange during 2010-2014. The result on this study shows that managerial optimism, firm value, and firm size that are occurred in the previous period have positive significantly impact on debt financing, whereas firm performance in the previous period has negative significantly impact on debt financing.

  10. Managerial Characteristics and its Impact on Organizational Performance: Evidence from Syria

    Directory of Open Access Journals (Sweden)

    Elias Milana

    2015-06-01

    Full Text Available This study aims to explore impact of managerial human capital in performance of a Syrian public organization, Directorate of Finance of province of Damascus, through use some of managerial characteristics are age, level of education, tenure and functional track. This study applied on a sample of 12 managers and 138 employees. The study reveals that there are no significant effect of age, level of education and functional track in performance of Directorate of Finance of province of Damascus, while there is a positive, strong and significant effect of tenure manager in organizational performance, which indicates that managerial characteristics almost irrelevant with performance of Directorate of Finance of the province of Damascus, and the public sector in general. Such results appear a need for efforts are invested in the formulation and implementation of human resource procedures and policies which can bring about effective change in behaviours and roles of the public managers and employees.

  11. Managerial accounting of costs in the system of management of enterprise logistics activity

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    L.G. Medvid

    2017-12-01

    Full Text Available The article deals with the analysis of scientific researches about the reflection of the logistics activity costs of a production enterprise in the system of analytical accounting. Practice shows that it is difficult to separate the reflection of logistics costs in primary documents in the system of financial accounting, and, as a result, the reflection in managerial reporting and the possibility of control and optimization. The research allows to determine the components of the organizational and methodical model of accounting of logistics costs according to the responsibility centers of production enterprises, namely, the system of responsibility centers according to the enterprise logistics activity, regulated documents, the system of budgetary logistics costs and internal managerial reporting according to the responsibility centers of the second level. This allowed to develop the methodological and organizational bases of managerial accounting of logistics activity costs of a productive enterprise.

  12. INVOLVEMENT OF MANAGERIAL ACCOUNTING IN ENSURING THE COMAPNY’S COMPETITIVENESS ON THE MARKET

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    ALINA-TEODORA CIUHUREANU

    2012-01-01

    Full Text Available The problem of costs is that they are an extremely complex variable of the company’s management, because of its importance in the management of each business. All managers need accurate and timely information to carry out pricing, planning, operation activities and to take other type of decisions. Managerial accounting is considered as an indispensable system in the accounting activity of the organisation for decision making. Regardless of where they are, managers administrate their field of responsibility, start actions that will lead to effects only by means of resources consumption. But, in order for the effects to be favourable to the organisation, managerial accounting demonstrates its usefulness in establishing what is profitable, in terms of costs as decisive factors for determining prices, this system being implemented through the managerial accounting, as part of the accounting activity performed within the organisation.

  13. MANAGERIAL DECISION IN INNOVATIVE EDUCATION SYSTEMS STATISTICAL SURVEY BASED ON SAMPLE THEORY

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    Gheorghe SĂVOIU

    2012-12-01

    Full Text Available Before formulating the statistical hypotheses and the econometrictesting itself, a breakdown of some of the technical issues is required, which are related to managerial decision in innovative educational systems, the educational managerial phenomenon tested through statistical and mathematical methods, respectively the significant difference in perceiving the current qualities, knowledge, experience, behaviour and desirable health, obtained through a questionnaire applied to a stratified population at the end,in the educational environment, either with educational activities, or with simultaneously managerial and educational activities. The details having to do with research focused on the survey theory, turning into a working tool the questionnaires and statistical data that are processed from those questionnaires, are summarized below.

  14. PSYCHO-SOCIAL PERCEPTIONS AND MANAGERIAL PREFERENCES OF WOMEN ENTREPRENEURS IN WESTERN ROMANIA

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    Borza Adriana

    2010-12-01

    Full Text Available Our study aims at identifying correlations between preferences and psycho-social choices of women entrepreneurs, more precisely the effect of these characteristics on a given managerial strategy. Based on the data obtained through the administration of two types of questionnaires, we analyzed the relations between social and psychological set of perceptions and managerial strategy. Social success and managerial performance are related with these perceptions and thus we can identify a significant conversion of mentalities determined by the governmental changes which took place in Eastern Europe after 1990. The data presented here are driven from the research conducted within the project ”Entrepreneurship and equality of chances. A inter-regional model of entrepreneurship training for women in western Romania”.

  15. Farmers’ managerial thinking and management process effectiveness as factors of financial success on Finnish dairy farms

    Directory of Open Access Journals (Sweden)

    Heikki Mäkinen

    2013-12-01

    Full Text Available The objective of the study was to analyze how farmers’ managerial thinking and management process effectiveness contribute to profitability of farming. A structural equation model of these two elements of management capacity and financial performance was applied on survey data and bookkeeping results from 117 dairy farms. The model explained one-fourth of the varying profitability of sample farms. The results show that farmers’ managerial thinking is connected to farm profitability, but management process effectiveness is not. It was concluded that it is essential for good performance that the farmer has a clear vision of developing farming with business and investment plans. Successful farmers also have a firm confidence in their managerial skills, a strong emphasis on instrumental and intrinsic values, and a high appreciation of farming as occupation. They also see the farm as an entrepreneurial business unit and intend to follow the corresponding principles of management.

  16. Service quality in the electricity industry: The role of privatization and managerial behavior

    Energy Technology Data Exchange (ETDEWEB)

    Fumagalli, Elena; Garrone, Paola; Grilli, Luca [Politecnico di Milano, Milan (Italy). Department of Management, Economics and Industrial Engineering

    2007-12-15

    This paper analyzes the relationship between privatization and service quality in the electricity industry, and tests the hypothesis that managerial behavior is a significant intervening factor. The sample includes 31 Italian distributors over the period 1998-2004; their quality performance is represented by continuity of supply, an aspect of quality that is both contractible and regulated. Results of the empirical analysis suggest that the transfer of shareholdings to private investors does not lead to quality degradation. The results also suggest that managerial dominance translates into a reduction in supply quality; this effect is likely to be particularly strong for public-sector utilities. (author)

  17. ORGANIZING OF MANAGERIAL ACCOUNTING IN THE FORMING OF INFORMATION BASE OF BUILDING ENTERPRISES PROVIDING DEVELOPMENT

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    Nadiia Pylypiv

    2017-03-01

    Full Text Available This article explores the impact of organization of managerial accounting on formation of informational base on the local (level of the individual enterprise, regional, disciplinary and national levels in the context of providing stable economic development for building enterprises. Based on our findings, we built a cognitive map of such an influence, which shows itself through different spheres, such as: economic, ecological and social, and will enjoy informational requests of management for improving of effectiveness of management system of such kind of  enterprises. Keywords: managerial accounting, organization, provision, stable economic development, building enterprises

  18. Service quality in the electricity industry: The role of privatization and managerial behavior

    International Nuclear Information System (INIS)

    Fumagalli, Elena; Garrone, Paola; Grilli, Luca

    2007-01-01

    This paper analyzes the relationship between privatization and service quality in the electricity industry, and tests the hypothesis that managerial behavior is a significant intervening factor. The sample includes 31 Italian distributors over the period 1998-2004; their quality performance is represented by continuity of supply, an aspect of quality that is both contractible and regulated. Results of the empirical analysis suggest that the transfer of shareholdings to private investors does not lead to quality degradation. The results also suggest that managerial dominance translates into a reduction in supply quality; this effect is likely to be particularly strong for public-sector utilities

  19. The Relationship between Managerial Satisfaction and Job Turnover Intention: The Mediating Role of Job Satisfaction

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    Rüveyda Öztürk Basol

    2017-09-01

    Full Text Available The growth of service sector in Turkey occurs faster than the other sectors and the number of shopping malls increases correspondingly. The rapid growth of the number of shopping malls has necessitated the measurement of the attitudes of the employees in this sector. This study demonstrated that the gender, marital status and age were not the significant variables on job satisfaction, managerial satisfaction and job turnover intention; however, education status and income status were found to be significant variables on job satisfaction and job turnover intention. In addition, job satisfaction fully mediated the relationship between managerial satisfaction and job turnover intention.

  20. Determinants of managerial competencies for primary care managers in Southern Thailand.

    Science.gov (United States)

    Mohd-Shamsudin, Faridahwati; Chuttipattana, Nirachon

    2012-01-01

    The purpose of this paper is first, to identify the critical managerial competencies of primary care managers; and second, to determine the relationship between personality and motivation, and managerial competency. A survey was conducted involving distribution of questionnaires to 358 rural primary care managers in Southern Thailand. The survey found six critical managerial competencies: visionary leadership; assessment, planning, and evaluation; promotion of health and prevention of disease; information management; partnership and collaboration; and communication. Both personality and motivation are found to significantly influence primary care managers' managerial competency. In particular, conscientiousness (i.e. perseveres until the task is finished, does a thorough job, full of energy, does things efficiently, and a lot of enthusiasm) is related to all managerial competencies. It is clear that extrinsic and intrinsic factors (i.e. quality of supervision and leadership, organizational policy and administration, interpersonal relationship, working conditions, work itself, amount of responsibility, and job recognition) are influential in primary care manager motivation that can significantly improve morale. The short version of the personality instrument may limit the generalization of some of the findings. Future research is needed to assess the relationship between managerial competency and performance. Further research could be done in other countries to see if this conclusion is in fact correct. It would also be useful to research if the findings apply to other health and social areas. Personality and motivation are able to co-predict managerial competency whereby motivation tends to have a stronger influence than personality. These findings will be useful to policy makers and to those responsible for the human development in the preparation of management training and development programs. Moreover, top management should not overlook the motivational system

  1. Intervening: Managerial Issues and Challenges in an Educational Management Development Program.

    Science.gov (United States)

    Barrilleaux, Louis E.; Schermerhorn, John R., Jr.

    The literature on intervention theory tends to overlook the pragmatic managerial issues and challenges of intervening. This paper analyzes the formative period of a school management development program to establish crucial differences between the program director's espoused theory and the actual experience of the intervention. These differences…

  2. New Technology and Changing Organisational Forms: Implications for Managerial Control and Skills.

    Science.gov (United States)

    Grimshaw, Damian; Cooke, Fang-Lee; Grugulis, Irena; Vincent, Steve

    2002-01-01

    Case studies of client relations in a call center and an information technology company's partnership with a government agency examined how new technology affects organizational structures and managerial control. Evidence suggests that new structures arise in tandem with technological changes and technology's use as a form of control differs in…

  3. From Managerialism to Communicative Competence: Control and Consensus in Educational Administration.

    Science.gov (United States)

    Watkins, Peter

    1986-01-01

    Traditional approaches to educational administration have generally reflected a managerial perspective based partly on scientific management principles developed by Frederick W. Taylor. Concerns with efficiency and administrative control have masked inequities and ideologies comprising organizational structure. Habermas's critique may help expose…

  4. Instructional, Transformational, and Managerial Leadership and Student Achievement: High School Principals Make a Difference

    Science.gov (United States)

    Valentine, Jerry W.; Prater, Mike

    2011-01-01

    This statewide study examined the relationships between principal managerial, instructional, and transformational leadership and student achievement in public high schools. Differences in student achievement were found when schools were grouped according to principal leadership factors. Principal leadership behaviors promoting instructional and…

  5. Foucault, Confucius and the In-Service Learning of Experienced Teachers in an Era of Managerialism

    Science.gov (United States)

    Huang, Hua

    2018-01-01

    By drawing on Foucault's theory of subjectification, this study presents a case study of two experienced teachers' in-service learning in the managerialist climate of Macau. The results indicate that the prevailing policies and administrative strategies on in-service learning served as the apparatus of managerialism working on teachers and…

  6. Impact of Terrorism on Managerial Efficiency of Heads of Secondary Schools in Khyber Pakhtunkhwa, Pakistan

    Science.gov (United States)

    Khattak, Usman Ghani; Iqba, Javed

    2015-01-01

    Terrorism has adversely affected the educational environment in Khyber Pakhtoon Khwa Province. This study was conducted to know the impact of Terrorism on managerial efficiency of heads of secondary schools in Khyber Pakhtoon Khwa that included Malakand, Mangawara, Dir, Hangu , Bannu and D I Khan which are the highly affected areas of terrorism.…

  7. The Managerial Motivation Models Appear To Be in the Family Way.

    Science.gov (United States)

    Lanser, Kris

    Managerial motivation models have evolved beyond the human resource tradition of the 1960s and the 1970s to a form of corporate involvement with the personal needs of employees, many of whose family lifestyles have changed dramatically. To analyze the new role for companies and the corporate concern for employees' well-being, this research study…

  8. Managerial Competence--Its Place in the Structure of University Teachers Competencies

    Science.gov (United States)

    Turturean Monica

    2012-01-01

    Higher education in Romania is passing though an authentic crisis caused by the necessity of our society to adapt to the European Union's demands. University teachers have a huge role in satisfying these requests. They need to possess a lot of competencies, and one of the most important is the managerial competency that will help university…

  9. Impact of Long-Term Communication Training on Managerial Style and Perceptions of Organization.

    Science.gov (United States)

    Cullinane, Laura E.; Stacks, Don W.

    A study examined the impact of a working commitment to corporate communication and corporate communication education on perceptions of management and managerial style and the more general perceptions of the organization. Subjects, 15 male mid-level managers at a large southeastern chemical plant that had in place a continuing corporate…

  10. Determinants of the use of value-based performance measures for managerial performance evaluation

    NARCIS (Netherlands)

    Dekker, H.C.; Groot, T.L.C.M.; Schoute, M.; Wiersma, E.

    2012-01-01

    As value-based (VB) performance measures include firms' cost of capital, they are considered more congruent than earnings measures. Prior studies, however, find that their use for managerial performance evaluation is less extensive than their presumed benefits would suggest. We examine how the

  11. Information Technology Managerial Capabilities and Customer Service Performance Among Insurance Firms in Nigeria

    Directory of Open Access Journals (Sweden)

    Sunday Adekunle Aduloju

    2014-12-01

    Full Text Available The potential of information technology (IT as an enabler of customer service process continues to generate interest, which is reflected in the large number of IT-related studies. In spite of the significant progress made in this area, research findings have been mixed and inconsistent. Also, the underlying mechanisms by which IT can affect customer service process remain underexamined. The aim of this study was to find out whether IT investments and IT managerial capabilities can account for variations in customer service performance among insurance companies in Nigeria. Using survey research design, the three formulated hypotheses were tested with data gathered from 402 staff at the managerial level drawn from the selected insurance companies in Nigeria, which have been among the largest investors in IT, and where customer service is widely perceived as strategically important. Responses were analyzed using linear regression. A major finding of this study is that IT is a necessary, but not sufficient, condition for sustainable competitive advantage in customer service. Results show that the interaction of IT investments and tacit, path-dependent, and firm-specific IT managerial capabilities significantly explains variations in customer service performance. Consequently, this study recommends that to realize IT-business value, investments in IT should be accompanied by building and developing IT managerial capabilities.

  12. Resilience as resistance to the new managerialism: portraits that reframe nursing through quotes from the field.

    Science.gov (United States)

    Cope, Vicki; Jones, Bronwyn; Hendricks, Joyce

    2016-01-01

    This paper acknowledges the relationship between resilience and the new managerialism of contemporary nursing. Qualitative portraiture methodology. The new managerialism in hospital settings results in a rapidly increasing turnover of acutely ill or comorbid patients, which directly relates to retention and quality service. In education settings, the management imperative to recruit more students into the profession combined with financial cutbacks leads to similar tensions. In aged care the trend equates care directly with funding, with the same effect. Yet despite this, many registered nurses remain working. Portraiture explored 'why' nurses remain in workplaces often described as awful. The resilience of nurses is seen through their stories and reframed to highlight resilience as a form of resistance to the new managerialism inherent in contemporary healthcare. This paper describes some of the hallmarks of new managerialism where workforce pressures force practices that do not value the 'human resource'. The quotes from the field give insight into the nurse's world view and have implications for managers, educators and employers, as well as for consumers of nursing care. © 2015 John Wiley & Sons Ltd.

  13. Managerialism, Organizational Commitment, and Quality of Job Performances among European University Employees

    Science.gov (United States)

    Smeenk, Sanne; Teelken, Christine; Eisinga, Rob; Doorewaard, Hans

    2009-01-01

    To achieve efficient and effective quality improvement, European universities have gradually adopted organizational strategies, structures, technologies, management instruments, and values that are commonly found in the private business sector. Whereas some studies have shown that such managerialism is beneficial to the quality of job performances…

  14. Learning in product innovation processes. Managerial action on improving learning behaviour

    NARCIS (Netherlands)

    Gieskes, J.F.B.

    2001-01-01

    Learning in and by organisations has been of great interest to practitioners and academics for a number of years now. However, publications on empirical research are few, especially in the context of product innovation.This thesis reports on research which was aimed at (a) effective managerial

  15. Establishing managerial requirements for low-and intermediate-level waste repository

    International Nuclear Information System (INIS)

    Chung, C. W.; Lee, Y. K.; Kim, H. T.; Park, W. J.; Suk, T. W.; Park, S. H.

    2004-01-01

    This paper reviews basic considerations for establishing managerial requirements on the domestic low-and intermediate-level radioactive waste repository and presents the corresponding draft requirements. The draft emphasizes their close linking with the related regulations, standards and safety assessment for the repository. It also proposes a desirable direction towards harmonizing together with the existing waste acceptance requirements for the repository

  16. Administrative and managerial controls for the operation of nuclear fuel reprocessing plants

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Guidelines are provided for the administrative and managerial controls necessary for the safe and efficient operation of nuclear fuel reprocessing plants. Topics covered include: administrative organization; review and audit; facility administrative policies and procedures; and tests and inspections. Recognizing that administrative practices vary among organizations operating nuclear fuel reprocessing plants, the standard incorporates flexibility that provides for compliance by any organization

  17. Emotional Expression at Different Managerial Career Stages: Female Principals in Arab Schools in Israel

    Science.gov (United States)

    Arar, Khalid

    2017-01-01

    This paper examines emotional expression experienced by female principals in the Arab school system in Israel over their managerial careers--role-related emotions that they choose to express or repress before others. I employed narrative methodology, interviewing nine female principals from the Arab school system to investigate expression of…

  18. Auditors of the Managerial University: Neo-Liberal Business Advisers or Paternal Controllers?

    Science.gov (United States)

    Reid, Ian C.

    2009-01-01

    Universities are increasingly being seen as commercial enterprises, and are represented as particular types of business entities in manuals provided to university managers. Critical discourse analysis is employed in this paper to construct an analytical framework for the study of managerial advice, which is then used to examine the manual provided…

  19. The Effect of the Research Assessment Exercise on Organisational Culture in English Universities: Collegiality versus Managerialism

    Science.gov (United States)

    Yokoyama, Keiko

    2006-01-01

    The purpose of the study is to identify the effect of the research assessment exercise (RAE) on the balance between collegiality and managerialism in English universities. The article examines the institutional strategies for the 2001 RAE and its effect on organisational culture, identifying change in governance, management and leadership in…

  20. Networking and Managers' Career Success in the Malaysian Public Sector: The Moderating Effect of Managerial Level

    Science.gov (United States)

    Rasdi, Roziah Mohd; Garavan, Thomas N.; Ismail, Maimunah

    2012-01-01

    Purpose: The purpose of this paper is to investigate how managerial level moderates the relationships between networking behaviours and career success (objective and subjective) in the context of a public sector organisation in Malaysia. Design/methodology/approach: The study utilised a cross-sectional design and investigated these relationships…

  1. From Principled Dissent to Cognitive Escape: Managerial Resistance in the English Further Education Sector

    Science.gov (United States)

    Page, Damien

    2011-01-01

    This article presents findings from a study of first tier managers (FTMs) within further education. While studies of managerial resistance are rare, this research highlights a range of resistant behaviours employed by first tier managers as they struggle to meet demands from students, their teams and the organisation. Resistance here is considered…

  2. The use of role playing in managerial learning: A socio constructivistic approach

    NARCIS (Netherlands)

    Ruiller, C.; Heijden, B.I.J.M. van der; Patin-Saint-Mieux, B.

    2014-01-01

    This research deals with role playing (RP) aimed at assisting learners to optimize their managerial style. While RP is often used in training sessions, contributions on its evaluations have decreased since the beginning of the 1980s. Although RP as a training method had been criticized for several

  3. The use of role playing in managerial learning: a socio constructivistic approach

    NARCIS (Netherlands)

    Ruiller, Caroline; van der Heijden, Beatrice; Patin-Saint-Mleux, Bertille

    2014-01-01

    This research deals with role playing (RP) aimed at assisting learners to optimize their managerial style. While RP is often used in training sessions, contributions on its evaluations have decreased since the beginning of the 1980s. Although RP as a training method had been criticized for several

  4. Market liquidity, investor participation and managerial autonomy: why do firms go private?

    NARCIS (Netherlands)

    Boot, A.W.A.; Gopalan, R.; Thakor, A.V.

    2005-01-01

    We analyze a publicly-traded firm's decision to stay public or go private when managerial autonomy from shareholder intervention affects the supply of productive inputs by management. We show that both the advantage and the disadvantage of public ownership relative to private ownership lie in the

  5. Managerial attention to exploitation versus exploration : Toward a dynamic perspective on ambidexterity

    NARCIS (Netherlands)

    Walrave, B.; Romme, A.G.L.; van Oorschot, K.E.; Langerak, F.

    2017-01-01

    Managerial attention to exploitation and exploration has a strong influence on organizational performance. However, there is hardly any knowledge about whether senior managers need to adjust their distribution of attention to exploitation and exploration in response to major changes in demand

  6. Constrained Optimization Problems in Cost and Managerial Accounting--Spreadsheet Tools

    Science.gov (United States)

    Amlie, Thomas T.

    2009-01-01

    A common problem addressed in Managerial and Cost Accounting classes is that of selecting an optimal production mix given scarce resources. That is, if a firm produces a number of different products, and is faced with scarce resources (e.g., limitations on labor, materials, or machine time), what combination of products yields the greatest profit…

  7. Plan before You Play: An Activity for Teaching the Managerial Process

    Science.gov (United States)

    Althouse, Norm R.; Hedges, Peggy L.

    2015-01-01

    This article describes a 60-minute classroom activity using LEGO® bricks that demonstrates and reinforces the importance of the managerial process. The activity, Plan Before You Play (PBP), is targeted to introductory business classes, and differs from others in that it requires little investment or up-front planning, is easily scalable, and, with…

  8. The Influnce of Metacognition on Managerial Hiring Decision Making: Implications for Management Development

    OpenAIRE

    Kumar, Angela Ewell

    1998-01-01

    THE INFLUENCE OF METACOGNITION ON MANAGERIAL HIRING DECISION MAKING: IMPLICATIONS FOR MANAGEMENT DEVELOPMENT by Angela Ewell Kumar (ABSTRACT) Cognitive processing has a primary role in decision making. In addition, metacognition, the regulation and knowledge of cognition, affects decision making in a consistent and predictable way. Novices explain situations in a simple way. Novices are more likely to make inappropriate decisions. Research suggests that train...

  9. Outcome-Based Education and Student Learning in Managerial Accounting in Hong Kong

    Science.gov (United States)

    Lui, Gladie; Shum, Connie

    2012-01-01

    Although Outcome-based Education has not been successful in public education in several countries, it has been successful in the medical fields in higher education in the U.S. The author implemented OBE in her Managerial Accounting course in H.K. Intended learning outcomes were mapped again Bloom's Cognitive Domain. Teaching and learning…

  10. A Business Communication Module for an MBA "Managerial Accounting" Course: A Teaching Note

    Science.gov (United States)

    Stout, David E.

    2014-01-01

    This Teaching Note describes a two-hour-and-40-minute "Business Communication" module developed and used by the author over the past six years in an MBA "Managerial Accounting" course at a university in the USA. The module has two modest but important goals: to sensitize graduate accounting students to the importance of…

  11. E-hancing the Master of Business Administration (MBA) Managerial Accounting Course

    Science.gov (United States)

    Zabriskie, Fern H.; McNabb, David E.

    2007-01-01

    Professional education, including managerial accounting education, at independent colleges and universities faces two challenges: (a) meeting shifting demand with static or declining resources and (b) ensuring that graduates gain the technological knowledge and skills that they need to succeed in their future careers. For many schools, the…

  12. The Accounting Class as Accounting Firm: A Model Program for Developing Technical and Managerial Skills

    Science.gov (United States)

    Docherty, Gary

    1976-01-01

    One way to bring the accounting office into the classroom is to conduct the class as a "company." Such a class is aimed at developing students' technical and managerial skills, as well as their career awareness and career goals. Performance goals, a course description, and overall objectives of the course are given and might serve as a model.…

  13. Collegiality and Managerialism: A False Dichotomy? Evidence from the Higher Education Literature

    Science.gov (United States)

    Tight, Malcolm

    2014-01-01

    Collegiality and managerialism are often portrayed as opposed ideas or practices, with the latter, in particular, either held up as a necessary response to the massification of higher education or portrayed as a betrayal of long-held academic ideals (as supposedly reflected in collegiality). This article explores how collegiality and managerialism…

  14. Managerial entrenchment, external discipline and accounting manipulations in the credit union industry

    NARCIS (Netherlands)

    Hillier, D.; Hodgson, A.; Stevenson-Clarke, P.

    2005-01-01

    This study examines the extended stakeholder corporate governance model in credit unions and the extent to which inherent managerial entrenchment impacts upon their operational decisions. Using Australian credit union data and the introduction of Basle-type capital adequacy regulations as a case

  15. Neoliberal Globalisation, Managerialism and Higher Education in England: Challenging the Imposed "Order of Things"

    Science.gov (United States)

    Beckmann, Andrea; Cooper, Charlie

    2013-01-01

    This article critically explores the consequences of the imposition of neoliberal ideology on a transnational scale on the higher education system. Its particular focus is England where the context of the "new managerialism" continues to dominate the "lifeworlds" of educators and the educated, despite strong concerns about its…

  16. Evaluation of the Determinants of Technological and Managerial Results of Cooperability in Brazilian Multinationals

    Directory of Open Access Journals (Sweden)

    Priscila Rezende da Costa

    2013-12-01

    Full Text Available The objective of this article was to evaluate the technological and managerial elements that determine the results of the cooperability in Brazilian multinationals (BMN.We conducted a survey among the universe of BMN and the data analysis was supported by Cronbach's Alpha testing, factorial analysis, correlation analysis, principal component analysis and multiple regression analysis. As a conclusion of the study on the elements of the technological trajectory, we found that the greater the experience in R&D in the headquarters, the more effective will be the technological results of cooperability and the greater the accumulated experience in R&D in foreign subsidiaries and international cooperation the more effective will be the managerial results of cooperability. We also found that the greater the degree of relevance of strategies for technological capacity building the more effective will be the results of cooperability, both technological and managerial. The aggregated analysis of technological inputs showed that the higher the investments in R&D and the number of internal and cooperative projects the more effective will be the technological results. However, as the company expands its project portfolio, grow the difficulties regarding alignment and management of the BMN, which may adversely affect the managerial results of cooperability.

  17. When salespeople develop negative headquarters stereotypes: performance effects and managerial remedies

    OpenAIRE

    Homburg, Christian; Wieseke, Jan; Lukas, Bryan A.; Mikolon, Sven

    2011-01-01

    This study examines the performance implications that organizations may suffer when their salespeople develop negative stereotypes of their corporate headquarters. How such stereotypes can be remedied through managerial action is also examined. The study draws on matched data from four different sources: sales managers, salespeople, customers, and company reports. Findings indicate that negative headquarters stereotypes among salespeople are associated with poor marketing-related ...

  18. Managerial Accounting Principles and Cost Calculation Used by Economic Entities in the Coal Mining Industry

    OpenAIRE

    Boca (Rakos) Ileana – Sorina; Vatasoiu Cristian Ionel

    2011-01-01

    Considering the specialized work in managerial accounting, this paper aims to show which cost calculation principles are actually applied in the coal mining industry today. The methodology used in this scientific approach is of qualitative nature, using the following methods: direct observation and interview.

  19. Integrating resource, social and managerial indicators of quality into carrying capacity decision making

    Science.gov (United States)

    Peter Newman; Robert Manning; Bill Valliere

    2002-01-01

    As use in national parks and related areas continues to rise and visitors and types of activities continue to diversify, we are challenged to balance use and preservation in parks, wilderness and related areas. Faced with these challenges, integrative approaches to defining, monitoring and managing ecological, social and managerial setting attributes is crucial. This...

  20. The Effect of Gender on the Importance of Business Ethics and Managerial Decisions: A Student Perspective

    Science.gov (United States)

    Keith, Nancy K.; Perreault, Heidi R.; Chin, Mary; Keith, Megan

    2009-01-01

    Objective: The study examined male and female business college students' perceptions regarding the need for a match between personal and corporate ethics, whether success in business depends on ethical behavior, and the types of ethical misconduct that warrant the most severe managerial disciplinary actions. Background: The literature contains…

  1. The Use of Poster Projects as a Motivational and Learning Tool in Managerial Accounting Courses

    Science.gov (United States)

    Altintas, Nergis Nalan; Suer, Ayca Zeynep; Sari, Emre Selcuk; Ulker, Mirac Sema

    2014-01-01

    Poster projects are an alternative method of motivation, learning, and information dissemination in education. The main purpose of this initial study was to determine the effect of poster projects on the motivational and learning process of managerial accounting students. In addition, the authors aimed to compare the opinions of managerial…

  2. Cow behaviour and managerial aspects of fully automatic milking in loose housing systems

    NARCIS (Netherlands)

    Ketelaar-de Lauwere, C.C.

    1999-01-01

    In this study of cow behaviour and managerial aspects of fully automatic milking, the emphasis was on implementing automatic milking systems (AMS) in cubicle houses in a way that suits cows and farmer. The starting points of the research were that the cows would visit the AMS voluntarily

  3. Friend or Foe? New Managerialism and Technical, Administrative and Clerical Support Staff in Australian Universities

    Science.gov (United States)

    Pick, David; Teo, Stephen; Yeung, Melissa

    2012-01-01

    The aim of this paper is to assess and conceptualise the effects of new managerialism-related organisational reforms in three Australian public universities on technical, administrative and clerical support staff job stressors and job satisfaction. Using a mixed method approach consisting of a quantitative core component and qualitative…

  4. The Impact of Diagnosing Skill Deficiencies and Assessment-Based Communication Training on Managerial Performance.

    Science.gov (United States)

    Papa, Michael J.; Graham, Elizabeth E.

    1991-01-01

    Evaluates an organizational diagnosis program that assesses managerial communication skills and provides the frame for follow-up training programs. Finds that managers participating in follow-up communication skills training performed significantly higher on interpersonal skills, problem-solving ability, and productivity over three long-term…

  5. Development and validation of a managerial decision making self-efficacy questionnaire

    Directory of Open Access Journals (Sweden)

    Wim Myburgh

    2015-05-01

    Full Text Available Orientation: Self-efficacy beliefs, given their task-specific nature, are likely to influence managers’ perceived decision-making competence depending on fluctuations in their nature and strength as non-ability contributors. Research purpose: The present research describes the conceptualisation, design and measurement of managerial decision-making self-efficacy. Motivation for the study: The absence of a domain-specific measure of the decision-making self-efficacy of managers was the motivation for the development of the Managerial Decisionmaking Self-efficacy Questionnaire (MDMSEQ. Research approach, design and method: A cross-sectional study was conducted on a nonprobability convenience sample of managers from various organisations in South Africa. Statistical analysis focused on the construct validity and reliability of items through exploratory and confirmatory factor analysis to test the factorial validity of the measure. Main findings: The research offers confirmatory validation of the factorial structure of the MDMSEQ. The results of two studies involving 455 (Study 1, n = 193; Study 2, n = 292 experienced managers evidenced a multidimensional structure and demonstrated respectable subscale internal consistencies. Findings also demonstrated that the MDMSEQ shared little common variance with confidence and problem-solving self-efficacy beliefs. In addition, several model fit indices suggested a reasonable to good model fit for the measurement model. Practical/managerial implications: The findings have implications for practical applications in employment selection and development with regard to managerial decision-making. Absence of the assessment of self-efficacy beliefs may introduce systematic, non-performance related variance into managerial decision-making outcomes in spite of abilities that managers possess. Contribution/value-add: Research on the volition-undermining effect of self-efficacy beliefs has been remarkably prominent

  6. Self-assessment of managerial knowledge and skills of medical doctors in primary health care

    Directory of Open Access Journals (Sweden)

    Aida Pilav

    2016-03-01

    Full Text Available Introduction: The aim of this paper was to evaluate the managerial knowledge and skills of mid-level managers – medical doctors in Medical center of the Canton Sarajevo.Methods: A cross-sectional study of the mid-level managers in the Medical center of the Canton Sarajevo was conducted using an originally developed questionnaire for self-assessment of managerial knowledge and skills. The respondents answered each of the questions using a 5-point Likert scale. Apart from the quantitative section, the respondents could present their observations concerning the educational needs in the health care system.Results: Almost 40% of the respondents said that the process of assessing health care needs is not conducted. No statistical significance was observed in the responses according to the length of service in a managerial position. In total, 41% of the respondents were not sure whether a plan exists, even though the development of these plans should be a principal managerial responsibility in the quality management. Managers who were longer in the position reported no plans for corrective actions. This result was in contrast with the answers obtained from the managers who were in the position for a shorter period. In addition, 91% of the respondents said that they regularly discuss problems with their employees.Conclusions: Self- assessment and assessment of managerial competencies should be regular activities in a health care organization, in order to monitor the knowledge and skills, as well as to make the development plans. The results of this study could serve as the basis for planning and developing the health management education in the Canton Sarajevo.

  7. Implementing managerial innovations in primary care: can we rank change drivers in complex adaptive organizations?

    Science.gov (United States)

    Longo, Francesco

    2007-01-01

    There has been much innovation in primary care in the past few decades. Although external and systemic constraints for health care organizations are relevant for their managerial evolution, there is also evidence that organizations operating under the same external pressures reach different levels of maturity. Which of the internal drivers available explain and foster change? Is it possible to rank change drivers by looking at their rate of efficacy in order to define a general change management path in the relationship between managers and physicians? The study is a hypothesis-generating work, designed to discuss a framework, consistent with the complex adaptive systems literature, for more effective internal change management approaches. We employed a qualitative approach to conduct a multiple case study in order to directly observe the evidence and to ask "key change players" for their perceptions. We studied different organizations all subject to the same external constraints in order to focus on the effects of internal change drivers. According to key players' opinions, the main drivers for managerial development are characteristics of the actors involved: their motivation, leadership, and commitment; the quality of relationships among the main actors; and how the resources dedicated to manage change are used. Given these criteria, any organizational strategy and goal seems to be achievable. This is consistent with the suggestions coming from the complex adaptive system literature. MANAGERIAL IMPLICATIONS: Managers have to consider the management of the relationship with professionals as the key success factor for implementing change. Managerial leadership has to be diffused in the organization both in the vertical and horizontal dimensions. Innovations need a medium or long-term perspective to become widely applied, and this requires a strong commitment which is related to managerial stability. Resources for innovation are to be considered a critical driver

  8. Henri Fayol’un Yönetim Düşüncesi Üzerine Notlar(Notes on Managerial Thought of Henry Fayol)

    OpenAIRE

    Ramazan ŞENGÜL

    2007-01-01

    Henri Fayol, developed a managerial approach which is a perfect guide for both private and public sectors through focusing systematically upon managerial process. A major advantage of Fayol in creating a general managerial doctrine was his pratician side. His managerial thought which was developed in the early 20th century lasted up to our times. The distinguished characteristic of Fayol’s thought was studying the administrative reality through separating it into its functions, in that it hel...

  9. Managerial Risk-taking in International Acquisitions in the Brewery Industry

    DEFF Research Database (Denmark)

    Geppert, Mike; Dörrenbächer, Christoph; Gammelgaard, Jens

    2013-01-01

    in the authors' view are significantly shaped by specific home country institutional influences. This study concerns the question of how different forms of ownership - concentrated (e.g. family and bank based) and dispersed (stock market based) - influence risk-taking and managerial decision-making in large......This paper deals with the role that institutional differences play in managerial risk-taking when firms engage in international acquisitions. It is assumed that multinational corporations (MNCs) have different interests and capabilities when dealing with international acquisition, which...... international acquisitions. Comparing a total of 12 large acquisitions of four leading MNCs in the global brewery industry, the paper shows that mutually reinforcing influences of country of origin (coordinated vs liberal market economies) and ownership (family ownership vs stock market ownership) lead...

  10. Exploring Managerial Commitment towards SPI in Small and Very Small Enterprises

    Science.gov (United States)

    O'Connor, Rory V.; Basri, Shuib; Coleman, Gerry

    This paper compares and contrasts the results of two similar studies into the software process practices in Irish Small and Very Small Enterprises. The first study contains rich findings in relation to the role and influence of managerial experience and style, with particular respect to the company founder and software development managers in small to medium seized enterprises (SMEs), whilst the second study contains extensive findings in relation to people and management involvement / commitment and SPI goal planning in very small enterprises (VSEs). By combining these results of these two studies of Irish SMEs/VSEs we can develop a rich picture of managerial commitment towards SPI and in particular explore the similarities between Small and Very Small Enterprises.

  11. Creativity in Managerial Accounting: the Syndrome of Clone-type Production Costs

    Directory of Open Access Journals (Sweden)

    Flavius-Andrei Guinea

    2016-01-01

    Full Text Available This study presents the complex and delicate subject of managerial accounting systems, aiming to highlight the motivational complex of developing creative accounting techniques and to identify certain creative accounting techniques at the border between legal and fraud. The field research undertaken was also aimed at identifying and possibly solving the problems related to identifying and presenting a set of creative accounting techniques in the practical context of implemented systems, focusing also on the consequences on the quality of the accounting information. The contributions of the study are highlighted particularly in the practical level, this aspect being obviously due to the types of research conducted. One of the fundamental objectives of the study was to spark the interest in the practical possibilities of protecting against the dangers occurring from a creative managerial accounting system.

  12. Reported time-management of work and managerial activities: Head and department nurses

    Directory of Open Access Journals (Sweden)

    Tomáš Kotrba

    2010-01-01

    Full Text Available Here the author presents results of a nursing time-management questionnaire research from seven hospitals in the Czech Republic. Target subjects were department and head nurses. Questionnaires were distributed and collected between Nov. 2009 and Dec. 2009 and were completed by 147 respondents. The aim of this study was to evaluate and analyze reported time management by department and head nurses in performing their managerial duties. Nurses were asked about their allocation of regular shift hours versus additional managerial task hours. Findings were compared between hospitals. The research was made possible through the informational system RELA. Questionnaire results were statistically analyzed and compared with the results of working analysis. Work analysis was collected from two Czech hospitals and included work hours from 37 head nurses (357 total work day records and 37 department nurses (363 work day records. Research was made by auto-screening method.

  13. FORMATION OF THE ICT COMPETENCE OF MANAGERIAL AND PEDAGOGICAL STAFF IN A NETWORKING

    Directory of Open Access Journals (Sweden)

    O. A. Kozlov

    2016-01-01

    Full Text Available The questions related to the preparation of modern pedagogical and managerial staff to implement the capabilities of information and communication technologies in the professional activities in terms of networking. The authors found that the scientific-pedagogical conditions of formation of the ICT competencies of management and teaching staff as the coordinator of modernization of education are: to form approaches and principles of formation of the ICT competencies of management and teaching staff and the willingness of the professional community in the formation of the ICT competencies of management and teaching staff as the modernization of the coordinators education in networking Determined ways and means to achieve teaching and administrative staff of professional ICT competence under network interaction. Said factors that provide an optimal model to achieve the professional pedagogical ICT competence and managerial personnel under network interaction.

  14. Managerial Decision Styles of Deans: A Case Study of a Malaysian Public University

    Directory of Open Access Journals (Sweden)

    Leele Susana Jamian

    2011-12-01

    Full Text Available It is often said that decision making style (DMS is reflective of leadership style. Numerous studies in the area of Management and Leadership indicate that DMS is a key factor that contributes to the success of both managers and their organizational performance. Using the Decision Making Styles Inventory (DMSI developed by Rowe and Boulgarides (1992, this paper examines the managerial DMS ofdeans in one of the Malaysian public universities. The scores derived from the DMS were categorized into four decision styles, namely directive, behavioural, analytical and conceptual. The findings revealed that a majority of the deans adopted at least one very dominant or dominant DMS, i mainly behavioural DMS, along with one or two back-up decision styles. Nevertheless, the overall individual results further revealed that the deans possessed more than one style implying that they have considerable flexibility in their managerial DMS and are able to change their decision styles from one situation to another with little difficulty.

  15. Core competencies necessary for a managerial psycho-educational training programme for business team coaches

    Directory of Open Access Journals (Sweden)

    Jeanette E. Maritz

    2009-06-01

    Full Text Available The objective of this research was to explore and describe core competencies necessary for a managerial psycho-educational training programme for business team coaches. The total number of participants in this qualitative research was 30. A purposive and snowball sampling strategy was used. Triangulation was achieved through focus groups, in-depth individual interviews and naïve sketches. Data were analysed through an open inductive approach and descriptive analysis. The results describe core competencies of a business team coach as situated within an Outcomes Based Education framework and relate to the knowledge to be discovered, skills to be mastered and the attitudes to be formed during a managerial psycho-educational training programme.

  16. Are managerial pressure, technological control and intrinsic motivation effective in improving data quality?

    International Nuclear Information System (INIS)

    Molina, Roger; Unsworth, Kerrie; Hodkiewicz, Melinda; Adriasola, Elisa

    2013-01-01

    Can data collectors be “pushed” into collecting high quality data or would being “pulled” be more effective? This paper finds that managers should be careful of the degree to which “push” factors, such as managerial pressure and technological input control, are relied upon. While they may be helpful for motivating those data collectors who are not intrinsically motivated, they are either not helpful or may discourage those data collectors who are intrinsically motivated. Instead, self-concordance may act as a longer-term, more stable approach to increasing the motivation of data collectors and thus increasing the quality of data that enter reliability systems. This study uses a sequential mixed-method approach involving interviews with 20 data collectors and a quantitative survey of 109 data collectors in a water utility. It examines the interactive effect of managerial pressure, technological input control and self-concordance on data collection performance

  17. Determining change in managerial practices implementation readiness in a gold mine / Yolandie Jansen van Vuuren

    OpenAIRE

    Jansen van Vuuren, Yolandie

    2011-01-01

    Performance Effectiveness Appraisal, Performance Effectiveness Review as well as Coaching and training are crucial elements of the performance management process included in a set of managerial competencies required by managers in a deep level gold mine in South Africa. This dissertation provides a contemporary review of performance management and gold mining in a South African deep level gold mine context. It provides a theoretical framework for the processes of Performance Effectiveness ...

  18. The Impact of Managerial Leadership on Stress and Health Among Employees

    OpenAIRE

    Nyberg, Anna

    2009-01-01

    The overall aim of this thesis was to explore the relationship between managerial leadership on the one hand and stress, health, and other health related outcomes among employees on the other. This was done in five studies, three using a cross-sectional and two a prospective design. In all studies the employees rated their managers with a self-administered questionnaire. The health outcomes were in four of the studies self-reported, but in the last study register-based diagn...

  19. Service employee adaptiveness : exploring the impact of role-stress and managerial control approaches

    OpenAIRE

    Sahadev, S; Purani, K; Panda, T

    2017-01-01

    The research aims to explore the relationships between managerial control strategies, role stress and employee adaptiveness among call center employees.\\ud Based on a conceptual model, a questionnaire based survey methodology is adopted. Data was collected from call center employees in India and the data was analysed through PLS methodology.\\ud The study finds that Outcome control and activity control increase role stress while capability control does not have a significant impact. The intera...

  20. In search of the perfect manager? Work-life balance and managerial work

    OpenAIRE

    Ford, J; Collinson, D L

    2011-01-01

    Work-life balance debates continue to proliferate but give relatively little critical attention to managerial workers. This article draws on research into the experiences of managers in a local government organization revealing an intricate, multifaceted and heterogeneous picture of fragmentation, conflicting demands, pressures and anxieties. The study highlights the importance of paid work for public sector managers; the concomitant difficulties in controlling working hours for those in mana...

  1. Empowering communication as an aspect of managerial communication in the training and development of principals

    OpenAIRE

    2012-01-01

    D.Ed. On surveying education in South Africa, it becomes clear that there is a vast and pervasive effort to reform schools. Criticism from several quarters regarding the lack of effective managerial skills of principals including empowering communication indicates the importance of research into the communicative competencies of educational managers. The development of training programmes in effective communication skills for principals is thus imperative. A group of M.Ed. students from th...

  2. The integration of online face-to-face social networking: the need for managerial reconfiguration

    OpenAIRE

    B. Imperatori; D. Ruta

    2013-01-01

    Purpose — The chapter explores if and how online and face-to-face organizational environments can interact, and if and how this interaction could foster managerial practices to sustain personal growth, organizational development, and employee–organization relationships. Methodology — Research project is based on an emblematic case study: fubles.com is a social sport sharing platform with one of the most active sport communities in Europe. This case is representative of a novel initiative, ...

  3. Negotiation with teachers as a managerial task of the school principal / Sewagodimo Amos Sebetlele

    OpenAIRE

    Sebetlele, Sewagodimo Amos

    2005-01-01

    The study focuses on the use of negotiation skills as a managerial task of the school principal in order to reduce conflicts between teachers and between teachers and themselves, so as to enhance a good working interpersonal relationship between them. This will lead to the building of trust, professional development and success. The purpose of this study was to determine through a literature study and empirical investigation, the nature of negotiation in schools and the skills ...

  4. Essential managerial attributes of the nowadays nursing service manager in the South African context

    Directory of Open Access Journals (Sweden)

    K Jooste

    2003-09-01

    Full Text Available Nursing service managers need certain essential managerialattributes in taking the lead in effective management ofthe nowadays health care organisations in South Africa.Major changes in restructuring and human resources planningare taking place through transformation of health servicesand specific managerial attributes are needed in thisscenario. Without nursing service managers with the necessarymanagerial attributes, change in the health care environmentwill be hampered and planning, organising, directingand control of the delivering of quality care will benegatively influenced.

  5. Involvement of Managerial Accounting in Ensuring The Comapny’s Competitiveness on The Market

    OpenAIRE

    Alina-Teodora Ciuhureanu

    2012-01-01

    The problem of costs is that they are an extremely complex variable of the company’s management, because of its importance in the management of each business. All managers need accurate and timely information to carry out pricing, planning, operation activities and to take other type of decisions. Managerial accounting is considered as an indispensable system in the accounting activity of the organisation for decision making. Regardless of where they are, managers administrate their field of ...

  6. Impact of the Managerial Communication upon the Work Productivity in Organization

    OpenAIRE

    Luminita Lupu; Monica Voicu

    2006-01-01

    The main objective of the paper is to analyze on a real cases how communication offer gains on work productivity. The authors present on their researche results in the N-E Region organizations, which have real problems in work productivity. The conclusions of these researches are useful to managers to identify and analyze all factors which determine the the work productivity increases and the importance of managerial communication in these problems.

  7. The effects of perceived managerial support on organizational commitment: An example of professional football players

    Directory of Open Access Journals (Sweden)

    İlhan ADİLOĞULLARI

    2017-12-01

    Full Text Available Aim: The aim of the study was to examine the effect of the support from managers that the professional footballers perceive in their commitment to their teams. Material and Methods: In this study, 641 professional football players were randomly participated from the professional football leagues organized by Turkish Football Federation in the season of 2015-2016. Data were collected by administrating the “Perceived Managerial Support Questionnaire” developed by Giray and Sahin (2012 and the “Organizational Commitment Questionnaire” which developed by Meyer and Allen (1997 and adapted to Turkish language by Wasti (2000 that has three subscales and 18 items. The data obtained in the study were evaluated by the Mann Withney U test, the Kruskal-Wallis test and the regression analyses as well as the percent-frequency analyses via SPSS programme. Results: Results revealed that there was a significant relationship between the level of organizational commitment and managerial support of professional football players that they perceive from their managers. In relation to perceived managerial support of football players, there was a significant difference between the groups according to league category and educational status of football players who participated in the present study. Furthermore, there was a significant difference in the level of organizational commitment among the groups according to football players’ age, level of league, educational status and duration of professional football career. Conclusion: According to results of this study that the professional football players’ commitment of their teams is predicted by the perceived managerial support from their managers is considered as an important conclusion. In this premise, results of the present study shed light on our understanding of the organizational management in football to be aware of football player’s expectations from their managers and provide such awareness in

  8. Public sector restructuring: The institutional and social effects of fiscal, managerial and capacity-building reforms

    OpenAIRE

    Bangura, Yusuf

    2000-01-01

    There have been tremendous pressures in the 1990s to change the character and functions of the state in developed and developing countries alike. Multilateral financial agencies and neoliberal analysts question the state's nationalistic, hierarchical, redistributive and interventionist character, which they believe is partly responsible for poor service delivery and economic performance in many countries. They seek to transform the state into a market-friendly, lean, managerial, decentralized...

  9. A Theoretical Assessment on Emotional Intelligence as a Competitive Managerial Skill

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    Burcu Hacioglu

    2014-03-01

    Full Text Available Emotion as the main motive underlying the human behaviors is a conceptthat has been researched by many disciplines in the social sciences. Derivingfrom behavioral studies on emotions, Emotional Intelligence as acritical concept in organizational behavior studies is attached to theassestment of employee motivation and performance drivers. In this study, atheoretical framework for the emotional intelligence in workplace has beenassessed. The major contribution of the concept in competitive business strategiesfrom managerial scope has been evaluated.

  10. Investment cash flow sensitivity under managerial optimism: new evidence from NYSE panel data firms

    OpenAIRE

    Mohamed, Ezzeddine Ben; Fairchild, Richard; Bouri, Abdelfettah

    2014-01-01

    Investment cash flow sensitivity constitutes one important block of the corporate financial literature. While it is well documented in standard corporate finance, it is still young under behavioral corporate finance. In this paper, we test the investment cash flow sensitivity among panel data of American industrial firms during 1999-2010. Using Q-model of investment (Tobin, 1969), we construct and introduce a proxy of managerial optimism following Malmendier and Tate (2005a) to show the impac...

  11. Competitive position, managerial ties, and profitability of foreign firms in China: an interactive perspective

    OpenAIRE

    Julie Juan Li; Kevin Zheng Zhou; Alan T Shao

    2009-01-01

    Despite the prominence of the competitive strategy perspective, it remains unclear whether foreign firms entering China can still adopt a differentiation or low-cost position to achieve superior performance, given the unique market and institutional environments in China. Alternatively, should foreign firms follow conventional wisdom and actively build managerial ties with government officials and business community to enhance their performance? This study develops and tests an interactive pe...

  12. The international business of higher education – a managerial perspective on the internationalisation of UK universities.

    OpenAIRE

    Warwick, P.

    2014-01-01

    This paper employs a managerial perspective to examine the internationalisation of higher education (HE). Using four case studies of United Kingdom (UK) universities, the research identifies the differences between organisations that are making good progress toward implementing their internationalisation strategy and those that are finding it more difficult. The literature review combines three sets of literature on: the internationalisation of HE, management of HE institutions and strategic ...

  13. The Role of Batch Costing and Cost Accounting in the Managerial Process

    OpenAIRE

    Ciumag, Marin; Ciumag, Anca

    2008-01-01

    Starting from the premises that the informational system is a part of the management system of any company, it is always stated, completely rightly that the effectiveness of an company strictly related to the way in which this knows how to manage the information. One of the problems the economic agents encounter nowadays is the lack of some coherent and well structured information that should assist the managerial decision at a superior level, as well as at inferior echelons. Once with ...

  14. WTO Accession and Managerial Challenges for Manufacturing Sectors in Southern China

    OpenAIRE

    Yeung, G; Mok, V

    2002-01-01

    Based on 31 case studies, this study tests the validity of four major managerial hypotheses for manufacturers in China after WTO accession. It is argued that the skills of managers will be severely tested in four specific areas after China accedes to the WTO: (1) preparing for trade disputes with their overseas competitors, (2) developing newer and higher value-added products and diversifying their markets, (3) selecting the appropriate localization strategy, and (4) upgrading manufacturing p...

  15. The Relationship between Managerial Satisfaction and Job Turnover Intention: The Mediating Role of Job Satisfaction

    OpenAIRE

    Rüveyda Öztürk Basol; Harun Demirkaya

    2017-01-01

    The growth of service sector in Turkey occurs faster than the other sectors and the number of shopping malls increases correspondingly. The rapid growth of the number of shopping malls has necessitated the measurement of the attitudes of the employees in this sector. This study demonstrated that the gender, marital status and age were not the significant variables on job satisfaction, managerial satisfaction and job turnover intention; however, education status and income...

  16. The Perception of the Internal Managerial Control System – the Case of the Romanian Public Entities

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    State Violeta

    2017-01-01

    Full Text Available In order to control the management of activities for achieve the objectives, the managers at all levels of the hierarchy must have relevant information on the organization's events and activities, in an appropriate form and detail. Thus, they can assume their responsibilities. In this context, we considered that important of organizing and implementing in the public entities of the system of internal managerial control. This system provides reasonable assurance that the organization's objectives will be achieved in terms of efficiency, efficacy, economically. For this purpose, we have carried out a documentary research of both specialized papers and the applicable regulations in force in Romania in the field of managerial internal control within the public entities, as well as empirical research. Thus, in a conjunct survey, we conducted a survey on the implementation of the managerial internal control system in different public institutions in Romania with the central objective to highlight the perception of the staff involved in this tool at the disposal of the management.

  17. INTERDEPENDENCIES OF THE INTERNAL / MANAGERIAL CONTROL STANDARD NO. 6 - ORGANIZATIONAL STRUCTURE

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    Ionut-Cosmin BĂLOI

    2015-06-01

    Full Text Available Our initiative of analyzing the internal control standard which deals with the organizational structure comes from the observations on the significance of these essential aspects of modern management and on the sensitivity with which this standard is treated in most of the public institutions considered representative for the Oltenia region. Although the administrators of public institutions strive to optimize the systems of internal/managerial control, they frequently face many issues concerning the misunderstanding of these standards, vaguely explained, for example throughout some guidelines or other documents. The hypothesis of our study is that most of public institutions face gaps in understanding, interpreting, adapting and implementing an effective model of organizational structure, and the causes are due to the lack of an interdependent, correlated approach of the pillars that support the internal/managerial control system: the 25 standards required by the Romanian legislation. Our study critically describes the superficial approach founded in the self-evaluation reports of the public institutions, if we refer only to the conformity of the organizational structure and the four standards that we consider inextricably related with this internal/managerial control standard. From the methodological point of view, our study tests the correlation between the level of compliance of these standards and the functionality of the system composed by them in the public organizations that we have investigated.

  18. A phenomenological exploration of intellectual disability: nurse's experiences of managerial support.

    Science.gov (United States)

    Galvin, Geraldine; Timmins, Fiona

    2010-09-01

    The present study aimed to explore Registered Nurse Intellectual Disabilities (RNIDs) experiences of managerial support. The current work environment for RNIDs is undergoing immense change. These changes include the introduction of social care leaders and care staff to care for people with an intellectual disability (ID) and community-based approaches to care. This has led to ambiguity and marginalization for RNIDs thus requiring them to re-establish their role boundaries. Support is thus required, through this change process, with managers required to lead and support RNIDs through this process. A Heideggerian constructivist phenomenological approach was used. Four overarching themes emerged from the data: The Professional Role of the Clinical Nurse Manager (CNM), Leadership Role of the CNM, Personal Supports and the Effects of CNM support. The themes found in this research study correlate with findings of other research studies on nurses' experiences of managerial support in various nurse settings. The findings of this research study will illuminate and create an understanding for nurses, nurse managers and ID services of what managerial supports are to this specific group of RNIDs working in this service for people with an ID. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  19. Beyond clinical engagement: a pragmatic model for quality improvement interventions, aligning clinical and managerial priorities.

    Science.gov (United States)

    Pannick, Samuel; Sevdalis, Nick; Athanasiou, Thanos

    2016-09-01

    Despite taking advantage of established learning from other industries, quality improvement initiatives in healthcare may struggle to outperform secular trends. The reasons for this are rarely explored in detail, and are often attributed merely to difficulties in engaging clinicians in quality improvement work. In a narrative review of the literature, we argue that this focus on clinicians, at the relative expense of managerial staff, has proven counterproductive. Clinical engagement is not a universal challenge; moreover, there is evidence that managers-particularly middle managers-also have a role to play in quality improvement. Yet managerial participation in quality improvement interventions is often assumed, rather than proven. We identify specific factors that influence the coordination of front-line staff and managers in quality improvement, and integrate these factors into a novel model: the model of alignment. We use this model to explore the implementation of an interdisciplinary intervention in a recent trial, describing different participation incentives and barriers for different staff groups. The extent to which clinical and managerial interests align may be an important determinant of the ultimate success of quality improvement interventions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  20. STUDY REGARDING THE ALLOCATION OF PRODUCTION OVERHEADS PROCEDURE: CONVENTIONALITY, SUBJECTIVITY AND INFORMATION DISTORTION IN MANAGERIAL ACCOUNTING

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    GUINEA FLAVIUS-ANDREI

    2017-02-01

    Full Text Available Traditional methods of cost calculating have become obsolete. The loss of relevance of traditional cost calculating systems is mainly due to the existence of a gap between the current model of enterprise control and the model of analysis centres, as well as the difference between the way of composing the actual cost and its image reflected by managerial accounting. The vision of the company on which the method of analysis centres was based no longer corresponds to the present reality. The approach of this study captures the complex and delicate subject of the allocation of production overheads procedure. Through the field research undertaken, it was aimed to identify and possibly solve the problems related to the rational allocation of these expenditures. The own contributions of the study are highlighted in particular at practical level, as an obvious result of the types of research undertaken. One of the fundamental objectives of the present study is to enhance the interest regarding the practical possibilities of protecting against the dangers of a creative managerial accounting system. A managerial accounting system, once implemented, will also attract the manifestation of creative accounting phenomena, especially in times of crisis. Having at their disposal the most relevant set of information, managers are tempted to resort to more or less ingenious techniques that are more or less questionable and more or less legal, in order to improve the financial statement presentation.

  1. Nurse entrepreneurs' attitudes to management, their adoption of the manager's role and managerial assertiveness.

    Science.gov (United States)

    Sankelo, Merja; Akerblad, Leena

    2008-10-01

    This study explores the attitudes of Finnish nurse entrepreneurs to management, their adoption of the manager's role, managerial assertiveness, development and training needs in management and associated factors. The research was conducted as part of a questionnaire survey among 335 entrepreneurs with different educational backgrounds. The sample for the study reported here consisted of those respondents who had a registered nurse degree. The data were analysed using SPSS statistical software. Nurse entrepreneurs took a positive attitude towards management, but there were obvious shortcomings in their adoption of the manager's role. They also showed a lack of managerial assertiveness. Half of the respondents had development needs and one-third had training needs in relation to management. Nurses who are planning to start up in business should have earlier leadership experience and should attend some form of management training. The provision of care and nursing services is increasingly taking place in the private sector. This study contributes to our understanding of the managerial role of nurse entrepreneurs in this new environment.

  2. Strategic Management in Hospitals: Tensions between the Managerial and Institutional Lens

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    Lucilaine Maria Pascuci

    2017-07-01

    Full Text Available The relationship between organizations and their environments has been object of study by scholars of the theory of organizations and in discussions concerning organizational strategy. When these perspectives come together, two sets of different but overlapping forces in the strategy formation process are highlighted. The purpose of this study is to analyze how strategic management contributed to reducing tensions derived from managerial and institutional logics in philanthropic hospitals. It is a comparative case study, with a multi-method approach. The data were examined using narrative and document analysis techniques. The analysis indicated that integrating organizational-managerialist and institutional perspectives raises continuous tensions within organizations with a direct impact on managerial decisions, strategic actions and performance. The strategic management approach should be sensitive enough to recognize and reduce these tensions and find ways to integrate them more effectively. This effort requires a combination of strong leadership skills and appropriate managerial tools. Flexibility, adaptability, creativity and informal interactions should be the basis of any strategic initiatives. Daring and innovation of the hospitals - more than acquiescence - are essential to their social and financial sustainability.

  3. REVISITING SCHEIN (1965 STUDY ON THE MANAGERIAL VALUES AND ATTITUDES OF MBA STUDENTS

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    A. Gonul Demirel

    2015-04-01

    Full Text Available As schools are organized networks of socializing experiences which prepare individuals to act in society, MBA programs are the socializing media to prepare the future managers. Our study is “a partial replication” of the study done by Schein (1965. The same constructs are used in the questionnaire of the present study. Assuming that what is valued by managers influences how those individuals make business decisions, we aim to find out the managerial values and attitudes of MBA students. We also aim to draw the attention of the faculty members to think about what attitudes, beliefs, and values MBA students are learning and what might the faculty contributions be to the transfer of managerial values. Therefore, the main question of our study is “What are the major managerial values and attitudes of our MBA students?” A second intended contribution of this study is the validation of the scales. The goal of science is empirical generalization, or knowledge development. Systematically conducted replications with extensions facilitate this goal. Keeping this in mind our reconsidering the original constructs of the Schein (1965 study contributes to the validation of at least some of these original constructs.

  4. Assessing managerial information needs: Modification and evaluation of the Hospital Shift Leaders' Information Needs Questionnaire.

    Science.gov (United States)

    Peltonen, Laura-Maria; Lundgrén-Laine, Heljä; Siirala, Eriikka; Löyttyniemi, Eliisa; Aantaa, Riku; Salanterä, Sanna

    2018-03-01

    The aims were (1) to evaluate the modified version of the Intensive Care Unit Information Need Questionnaire for the broader hospital setting, and (2) to describe the differences in respondents' managerial activities and information needs according to the position held by the respondent and the type of hospital unit. Information systems do not support managerial decision-making sufficiently and information needed in the day-to-day operations management in hospital units is unknown. An existing questionnaire was modified and evaluated. Shift leaders, that is, the nurses and physicians responsible for the day-to-day operations management in hospital units were reached using purposive sampling (n = 258). The questionnaire ascertained the importance of information. Cronbach's α ranged from .85-.96 for the subscales. Item - total correlations showed good explanatory power. Managerial activities and information needs differed between respondents in different positions, although all shared about one-third of important information needs. The response rate was 26% (n = 67). The validity and reliability of the questionnaire were good. Attention should be paid to the positions of shift leaders when developing information systems. The questionnaire can be used to determine important information when developing information systems to support day-to-day operations management in hospitals. © 2018 John Wiley & Sons Ltd.

  5. Leadership Styles of Russian Enterprise Managers: The Effect of Transactional and Transformational Behaviors on Employees' Evaluation of Managerial Performance.

    Science.gov (United States)

    Ardichvili, Alexander

    2001-01-01

    Identifies leadership styles of Russian enterprise managers and determines how theses styles are related to employees' subjective evaluation of managerial performance. Highlights include laissez-faire leadership, transactional leadership, and transformational leadership; international leadership research; and implications for Russian leadership…

  6. The effects of a sound-field amplification system on managerial time in middle school physical education settings.

    Science.gov (United States)

    Ryan, Stu

    2009-04-01

    The focus of this research effort was to examine the effect of a sound-field amplification system on managerial time in the beginning of class in a physical education setting. A multiple baseline design across participants was used to measure change in the managerial time of 2 middle school female physical education teachers using a portable sound-field amplification system. Managerial time is defined as the cumulative amount of time that students spend on organizational, transitional, and nonsubject matter tasks in a lesson. The findings showed that the amount of managerial time at the beginning of class clearly decreased when the teacher used sound-field amplification feedback to physical education students. Findings indicate an immediate need for administrators to determine the most appropriate, cost-effective procedure to support sound-field amplification systems in existing physical education settings.

  7. Book review:- Confronting Managerialism. How The Business Elite And Their Schools Threw Our Lives Out Of Balance.

    OpenAIRE

    English, Rachel A.

    2011-01-01

    This was a book review on:- Confronting Managerialism. How The Business Elite And Their Schools Threw Our Lives Out Of Balance. Author:- Robert R. Locke & J.C. Spender. Publisher:- Zed Books, London & New York.

  8. Critical analysis of the implications of new managerialism on ethical, democratic and professional values in public service

    Directory of Open Access Journals (Sweden)

    Jose G. Vargas-Hernández

    2016-01-01

    Full Text Available This paper aims to critically analyze the implications of the new managerialism in the public service through ethical, democratic and professional values. It assumes the contradictions between the values that seek to promote the public service under the model of managerialism and the reality of its implementation. The method used is analytical-descriptive-normative from the critical perspective of the parallel developments of managerialism and public service. The theoretical and methodological framework that serves as a reference for this critical analysis is provided by the theories of organizational economics and public choice. The discussion concludes that there is a necessary conflict between ethical, democratic and professional values of these new organizational forms promoted by managerialism through the theories of economics and organizational public choice and traditional values of public service.

  9. Managerial Objectives of the Annual Financial Statements. True and Fair View or „Users, Be Careful!”

    OpenAIRE

    Alina Teodora Ciuhureanu; Nicolae Balteş; Hortensia Gorski

    2009-01-01

    The financial statements represent the less expensive and the most widely spread managerial communication method. Starting from this aspect, the paper shows the managerial usefulness of the information offered by the financial statements. But, in order to take reality, and not „creativity” based decisions, the financial statements must offer a true and fair view of the company, the managers’ opinion regarding this matter being captured, through a selective research.

  10. Investigating whether a lack of marketing and managerial skills is the main cause of business failure in South Africa

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    S Radipere

    2014-07-01

    The study concludes that a lack of marketing and managerial skills has a negative impact on the success, viability and development of small businesses.  The challenge is to improve the managerial skills of small business owners, since the small business sector is widely considered to be the ideal site for the solving of South Africa’s unemployment problems and the rejuvenation of its stagnating economy.

  11. The Different Inhibition of Return (IOR Effects of Emergency Managerial Experts and Novices: An Event-Related Potentials Study

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    Rong Cao

    2017-05-01

    Full Text Available Inhibition of return (IOR is an important effect of attention. However, the IOR of emergency managerial experts is unknown. By employing emergency and natural scene pictures in expert-novice paradigm, the present study explored the neural activity underlying the IOR effects for emergency managerial experts and novices. In behavioral results, there were no differences of IOR effects between novices and emergency managerial experts, while the event-related potentials (ERPs results were different between novices and experts. In Experiment 1 (novice group, ERPs results showed no any IOR was robust at both stimulus-onset asynchrony (SOA of 200 ms and 400 ms. In Experiment 2 (expert group, ERPs results showed an enhanced N2 at SOA of 200 ms and attenuated P3 at cued location in the right parietal lobe and adjacent brain regions than uncued location at SOA of 200 ms. The findings of the two experiments showed that, relative to the novices, IOR for the emergency managerial experts was robust, and dominated in the right parietal lobe and adjacent brain regions, suggesting more flexible attentional processing and higher visual search efficiency of the emergency managerial experts. The findings indicate that the P3, possible N2, over the right parietal lobe and adjacent brain regions are the biological indicators for IOR elicited by post-cued emergency pictures for emergency managerial experts.

  12. The relationship between gender role stereotypes and requisite managerial characteristics: the case of nursing and midwifery professionals.

    Science.gov (United States)

    Berkery, Elaine; Tiernan, Siobhan; Morley, Michael

    2014-09-01

    To examine the relationship between gender role stereotypes and requisite managerial characteristics within the nursing and midwifery profession. Studies have been carried out to determine gender role stereotypes and requisite managerial characteristics across a number of industries and among student samples. No study has been carried out within the nursing and midwifery profession. In order to allow for direct comparisons with previous research Schein's Descriptive Index (SDI) was used. A total 239 undergraduate and 171 postexperience responses were collected. Female nurses and midwives did not gender type the managerial role, whereas males gender typed the managerial role in favour of men. Student nurses and midwives recorded a stronger correlation between women and management than their qualified counterparts. Males gender typed the managerial role in favour of men. With an increase in numbers of men joining the profession and increased representation of males at the Clinical Nurse Manager (CMN) level there is a possibility that the profession will become two tiered. Health care organisations should pay careful consideration to career development and implement career structures which ensure equal access to managerial roles for both genders. © 2012 John Wiley & Sons Ltd.

  13. Nurse safety outcomes: old problem, new solution - the differentiating roles of nurses' psychological capital and managerial support.

    Science.gov (United States)

    Brunetto, Yvonne; Xerri, Matthew; Farr-Wharton, Ben; Shacklock, Kate; Farr-Wharton, Rod; Trinchero, Elisabetta

    2016-11-01

    The aim of this study was to examine the impacts of nurses' psychological capital and managerial support, plus specific safety interventions (managerial safety priorities, safety training satisfaction), on nurses' in-role safety performance. Most hospitals in industrialized countries have adopted selective (often the least costly) aspects of safety, usually related to safety policies. However, patient safety remains a challenge in many countries. Research shows that training can be used to upskill employees in psychological capital, with statistically significant organizational and employee benefits, but this area is under-researched in nursing. Data were collected using a survey-based, self-report strategy. The emerging patterns of data were then compared with the findings of previous research. Quantitative survey data were collected during 2014 from 242 nurses working in six Australian hospitals. Two models were tested and analysed using covariance-based Structural Equation Modelling. Psychological capital and safety training satisfaction were important predictors of nurses' in-role safety performance and as predictors of nurses' perceptions of whether management implements what it espouses about safety ('managerial safety priorities'). Managerial support accounted for just under a third of psychological capital and together, psychological capital and managerial support, plus satisfaction with safety training, were important to nurses' perceptions of in-role safety performance. Organizations are likely to benefit from upskilling nurses and their managers to increase nurses' psychological capital and managerial support, which then will enhance nurses' satisfaction with training and in-role safety performance perceptions. © 2016 John Wiley & Sons Ltd.

  14. Managerial Discretion.

    Science.gov (United States)

    May, William J.

    1983-01-01

    Defines the principal's role as educational leader. Shows how the status of principals and the bureaucracy of public schools in Canada limit the principal's role. Explains the Canadian school budgeting process and its disadvantages. Suggests that school-based management can overcome educational centralization. (SB)

  15. Managerial Styles.

    Science.gov (United States)

    Halverson, Don E.

    This is one of a series of monographs on the application of management principles to educational organizations. This monograph is devoted to identifying that way of managing that opens up a system and frees the individuals therein to voluntarily, willingly, even enthusiastically, strive to achieve the goals of the organization. Emphasis is placed…

  16. Henri Fayol’un Yönetim Düşüncesi Üzerine Notlar(Notes on Managerial Thought of Henry Fayol

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    Ramazan ŞENGÜL

    2007-01-01

    Full Text Available Henri Fayol, developed a managerial approach which is a perfect guide for both private and public sectors through focusing systematically upon managerial process. A major advantage of Fayol in creating a general managerial doctrine was his pratician side. His managerial thought which was developed in the early 20th century lasted up to our times. The distinguished characteristic of Fayol’s thought was studying the administrative reality through separating it into its functions, in that it helps to understand evolution and operation of organisations. The importance of his doctrine for today is that adapting contemporary managerial techniques into organisations of various kinds needs to refer Fayol’s managerial aproach in one way or another.

  17. Managerial leadership and ischaemic heart disease among employees: the Swedish WOLF study

    Science.gov (United States)

    Nyberg, A; Alfredsson, L; Theorell, T; Westerlund, H; Vahtera, J; Kivimäki, M

    2009-01-01

    Objective: To investigate the association between managerial leadership and ischaemic heart disease (IHD) among employees. Methods: Data on 3122 Swedish male employees were drawn from a prospective cohort study (WOLF). Baseline screening was carried out in 1992–1995. Managerial leadership behaviours (consideration for individual employees, provision of clarity in goals and role expectations, supplying information and feedback, ability to carry out changes at work successfully, and promotion of employee participation and control) were rated by subordinates. Records of employee hospital admissions with a diagnosis of acute myocardial infarction or unstable angina and deaths from IHD or cardiac arrest to the end of 2003 were used to ascertain IHD. Cox proportional-hazards analyses were used to calculate hazard ratios for incident IHD per 1 standard deviation increase in standardised leadership score. Results: 74 incident IHD events occurred during the mean follow-up period of 9.7 years. Higher leadership score was associated with lower IHD risk. The inverse association was stronger the longer the participant had worked in the same workplace (age-adjusted hazard ratio 0.76 (95% CI 0.61 to 0.96) for employment for 1 year, 0.77 (0.61 to 0.97) for 2 years, 0.69 (0.54 to 0.88) for 3 years, and 0.61 (0.47 to 0.80) for 4 years); this association was robust to adjustments for education, social class, income, supervisory status, perceived physical load at work, smoking, physical exercise, BMI, blood pressure, lipids, fibrinogen and diabetes. The dose–response association between perceived leadership behaviours and IHD was also evident in subsidiary analyses with only acute myocardial infarction and cardiac death as the outcome. Conclusion: If the observed associations were causal then workplace interventions should focus on concrete managerial behaviours in order to prevent IHD in employees. PMID:19039097

  18. Destructive managerial leadership and psychological well-being among employees in Swedish, Polish, and Italian hotels.

    Science.gov (United States)

    Nyberg, Anna; Holmberg, Ingalill; Bernin, Peggy; Alderling, Magnus; Åkerblom, Staffan; Widerszal-Bazyl, Maria; Magrin, Maria Elena; Hasselhorn, Hans-Martin; Milczarek, Malgorzata; D'Angelo, Giuliana; Denk, Melanie; Westerlund, Hugo; Theorell, Töres

    2011-01-01

    The aim of this cross-sectional exploratory study was to investigate destructive managerial leadership in the hotel industry in Sweden, Poland, and Italy in relation to psychological well-being among employees. 554 questionnaires were collected from employees in all occupational groups within hotels. The Copenhagen Psychosocial Questionnaire (COPSOQ) measured working conditions, particularly iso-strain or high work demands combined with low control and poor social support, and psychological well-being, defined in terms of mental health, vitality, and behavioural stress. Items adapted from the Global Leadership and Organisational Behaviour Effectiveness (GLOBE) research program questionnaire measured autocratic, malevolent, and self-centred leadership styles. Differences in ratings between countries were estimated, as well as the relationship between destructive managerial leadership on an organisation level and employee psychological well-being on an individual level. The relationship between destructive leadership and psychological well-being among employees was adjusted for employees' reported iso-strain. Autocratic and malevolent leadership were at the organisation level related to low vitality among employees and self-centred leadership was significantly associated with poormental health, low vitality, and high behavioural stress. Autocratic and malevolent leadership were more strongly related to iso-strain than was self-centred leadership. Variations in leadership practice between countries were seen in autocratic and malevolent leadership. This exploratory study suggests a significant association between destructive managerial leadership on the organisation level and poor psychological well-being among employees on an individual level. Interventions to decrease iso-strain and enhance psychological well-being among employees could be directed at an organisation level.

  19. Managerial effort under asymmetric information: The case of public schools in Brazil

    Directory of Open Access Journals (Sweden)

    Alessio Tony C. Almeida

    2017-09-01

    Full Text Available This paper uses a principal-agent model to investigate how public school managers react to government incentives based on previous school performance. Using data from the Brazilian Student Evaluation Exam (Prova Brasil – PB and the School Census, we estimate a managerial effort function by quantile regression. The findings show a regular non-linear relationship between managerial effort and lagged school performance, indicating that marginal effort is decreasing when a previously ineffective school manager becomes effective on reaching a performance goal. This evidence is in line with the adopted theoretical approach and provides new parameters for educational policies designs. Resumo: Este artigo usa um modelo de principal-agente para investigar como os gestores de escolas públicas reagem à incentivos do governo baseados no desempenho escolar anterior. Utilizando dados da Prova Brasil (PB e do Censo Escolar, estimamos uma função de esforço gerencial por regressão quantílica. Os resultados mostram uma relação não-linear regular entre o esforço gerencial e o desempenho escolar desfasado, indicando que o esforço marginal decresce quando um diretor de escola anteriormente ineficaz se torna efetivo ao atingir uma meta de desempenho. Esta evidência está em linha com a abordagem teórica adotada e fornece novos parâmetros para o desenho de políticas educacionais. JEL classification: I21, H52, H40, Keywords: School management, Managerial effort, Educational goals, Asymmetric information, Palavras-chave: Gestão escolar, Esforço gerencial, Metas educacionais, Informação assimétrica

  20. Age differences in coping and locus of control: a study of managerial stress in Hong Kong.

    Science.gov (United States)

    Siu, O; Cooper, C L; Spector, P E; Donald, I

    2001-12-01

    The present study involved data collection from 3 samples of Hong Kong managers to examine mechanisms by which age would relate to work well-being. A total of 634 managers was drawn by random sampling and purposive sampling methods. The results showed that age was positively related to well-being (job satisfaction and mental well-being). Furthermore, older managers reported fewer sources of stress, better coping, and a more internal locus of control. Multiple regression analyses suggested that the relations of age with 2 well-being indicators can be attributed to various combinations of coping, work locus of control, sources of stress, managerial level, and organizational tenure.

  1. OPPORTUNITIES AND DANGERS THAT ARE BASED ON MANAGERIAL DECESIONS IN CONSTANTA

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    Lucica SINTEA (ANGHEL

    2016-05-01

    Full Text Available Constanta County represents a very strong economic force in Romania, but also in the European continent in general. Thus, Constanta, is facing numerous problems. The negative factors that have influenced Constanta County are mainly internal. Due to its position by the Black Sea, the County is also influenced by all international political events, by the decrease of the cereals in commodities exchanges, by the oil prices or the fluctuation of the exchange rate. However, most risks have emerged because of the managerial strategies implemented by companies or the state policy on the protection of national wealth. Our welfare, at micro and macroeconomic level, depends on administrative policies.

  2. The Importance of Managerial Communication in the Activity of a Firm

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    Marcel Laurentiu ROMANESCU

    2016-12-01

    Full Text Available Communication is a fundamental feature of existence. All managerial functions are made through communication, as a process of understanding between people by means of information transfer. In the attempt of defining the notion of communication it should not lose sight that this is a means and not an purpose, which gives managers the opportunity to lead. Communication, in management science, is known as a main activity of the managers, being considered as a component of the management function. Communication or exchange of information, ideas and feelings, was defined as an interpersonal process of transmission and reception of symbols that have meanings attached.

  3. A Theoretical Assessment on Emotional Intelligence as a Competitive Managerial Skill

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    Burcu Hacioglu

    2016-01-01

    Full Text Available Emotion as the main motive underlying the human behaviors is a concept that has been researched by many disciplines in the social sciences. Deriving from behavioral studies on emotions, Emotional Intelligence as a critical concept in organizational behavior studies is attached to the assestment of employee motivation and performance drivers. In this study, a theoretical framework for the emotional intelligence in workplace has been assessed. The major contribution of the concept in competitive business strategies from managerial scope has been evaluated.

  4. Differences in perceptions of managerial roles by gender among southern business students.

    Science.gov (United States)

    Smith, J O; Schellenberger, R E

    1991-12-01

    Perception of the roles necessary for managerial success based on the 10 verbal descriptors of the Mintzberg roles were gathered from 128 business students at a southern U.S. university. The objective was to assess whether these 72 men and 56 women viewed the importance of the roles differently. Ratings were collected on the 10 roles for each of four different types of managers. The data were analyzed by one-way analysis of variance, chi-squared analysis, and Spearman rank-order correlation. No differences were observed in the perception of men and women in these roles or of their relative importance.

  5. A COMPARATIVE ANALYSIS OF MANAGERIAL COMPETENCIES BASED ON EVIDENCE FROM SATU MARE COUNTY, ROMANIA

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    Olimpia Neagu

    2014-12-01

    Full Text Available The paper explores the managerial competencies of human resources in the companies from Satu Mare County, by comparing the employers' and employees' views. The comparison is based on data collected and processed within the project HURO/0901/264/2.2.2 implemented in partnership by "Vasile Goldiș" Western University and University of Debrecen and financed by European Union through ERDF under Hungary-Romania 2007-2013 Programme, in 2012, and on data collected and processed in 2013-2014, in a new field research applied to employees from Satu Mare county.

  6. How do Managerial Successions Shape Corporate Financial Policies in Family Firms?

    DEFF Research Database (Denmark)

    Amore, Mario Daniele; Minichilli, Alessandro; Corbetta, Guido

    2011-01-01

    Despite recent evidence on the importance of chief executive officer (CEO) successions in family firms, we still know little about the differences in corporate strategies entailed by family and professional managers around transition. We investigate the consequences of managerial successions...... financing: the increase in debt is particularly pronounced for young firms, firms with a high level of investment, and firms in which the controlling family maintains a dominant representation on the board of directors. Examining the importance of financial flexibility, we find that the increase in debt...

  7. Managerialism in the university management: implications of strategic planning in the perception of managers from a public university

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    Lucilaine Pascuci

    2016-04-01

    Full Text Available The transition from the bureaucratic public administration model to a more effective managerial model requires a new kind of behavior within public universities. As a response to demands of a new more competitive for better performance there is a growing trend among universities of incorporating managerial approaches oriented by the market, and characterized as managerialism. However, such practices have identified as inappropriate losing much of its effectiveness by neglecting the organizational complexity of universities, especially the public ones. The purpose of this study is to analyze the contributions and limitations of the strategic planning incorporated by a public university. The results indicate the existence of a consensus among the central administration and the academic units related to the need for a professionalization of public management. It is also stressed that the ambiguity of public policies and overload of regulations together with the complexity of the academic organization ended up being serious barriers to the success of managerial practices like the strategic planning. The main conclusions reveal that the success of such managerial approach requires the adjustment of the rationality implicit in the model to the specificities of the academic organizations, as a condition by which the efforts can generate the expected benefits.

  8. Accounting firms’ managers’ and trainees’ perceptions of managerial competencies required to manage diversity in KwaZulu-Natal, South Africa

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    Msizi V. Mkhize

    2017-10-01

    Full Text Available Background: In South Africa, there is a shortage of black chartered accountants, with some progress being made in transforming the industry. Accounting firms’ managers must be prepared to effectively manage the increasing diversity of the profession. Aim: The purpose of the study was to identify the managerial competencies required by accounting firms managers to effectively manage diversity in KwaZulu-Natal. Setting: The setting for this study is accounting firms in KwaZulu-Natal. Methods: A prospective, descriptive and analytical, cross-sectional design using systematic sampling was employed. The responses of 45 accounting firms’ managers and 114 trainees were analysed. Results: Both managers and trainees perceived the six managerial competencies important in managing diversity, but the ranking order of perceived importance indicated that there are variations in ratings. Teamwork and self-management competencies were highly rated by managers, while communication and teamwork competencies were highly rated by trainees. Conclusion: The managerial competencies are vital for the accounting firms’ managers. The study suggests that the accounting firms’ managers should consider the importance given by trainees and by themselves in prioritising the most important competencies they require in managing diversity. Accounting firms are encouraged to incorporate the six managerial competencies into the job descriptions or job advertisements and in the firms’ management development programme or training and development programme as the managerial competencies will assist managers in managing the diverse workforce effectively.

  9. Factors Relating to Managerial Stereotypes: The Role of Gender of the Employee and the Manager and Management Gender Ratio.

    Science.gov (United States)

    Stoker, Janka I; Van der Velde, Mandy; Lammers, Joris

    2012-03-01

    PURPOSE: Several studies have shown that the traditional stereotype of a "good" manager being masculine and male still exists. The recent changes in the proportion of women and female managers in organizations could affect these two managerial stereotypes, leading to a stronger preference for feminine characteristics and female leaders. This study examines if the gender of an employee, the gender of the manager, and the management gender ratio in an organization are related to employees' managerial stereotypes. DESIGN/METHODOLOGY/APPROACH: 3229 respondents working in various organizations completed an electronic questionnaire. FINDINGS: The results confirm our hypotheses that, although the general stereotype of a manager is masculine and although most prefer a man as a manager, female employees, employees with a female manager, and employees working in an organization with a high percentage of female managers, have a stronger preference for feminine characteristics of managers and for female managers. Moreover, we find that proximal variables are much stronger predictors of these preferences than more distal variables. IMPLICATIONS: Our study suggests that managerial stereotypes could change as a result of personal experiences and changes in the organizational context. The results imply that increasing the proportion of female managers is an effective way to overcome managerial stereotyping. ORIGINALITY/VALUE: This study examines the influence on managerial stereotypes of various proximal and distal factors derived from theory among a large group of employees (in contrast to students).

  10. Logistical modelling of managerial decisions in social and marketing business systems

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    Oleksandr Velychko

    2017-10-01

    Full Text Available Logistical modelling of business systems within the context of mathematical logistics, logistical management, operational research as well as rationalistic provision of logistics at an enterprise have been considered in the article. The research was carried out on the methodological basis which included the authors’ developments and implied conveying familiar knowledge on new objects within the field of linear programming. Scientific novelty concerns the development of categorical toolkit as well as the existing methodical approaches of rationalistic logistics to managerial decisions. Rational areas of using terms “logistical model” and “model of logistics” in business environment have been determined. The authors’ methodology of constructing logistical models in management of separate social and marketing systems of enterprises according to minimization and maximization criteria is presented. Ways of using modelling at not conventional objects of logistical support for managerial decisions have been suggested in the context of studying the moral psychological climate of staff and complex estimation of socioeconomic measures of staff management improvement. The procedure of logistical optimization in the system of distributing and advertising activity of the enterprise has been developed. Approbation of the developed models has been carried out and possibilities for further model’s complication by output data, variables, and limitations under specific practical conditions have been grounded.

  11. Exploratory Study Examining the Joint Impacts of Mentoring and Managerial Coaching on Organizational Commitment

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    Hyung Rok Woo

    2017-01-01

    Full Text Available A number of organizations have adopted coaching and mentoring interventions to discover and foster the potential capabilities of employees. These practices are seen as competitive drivers to cultivate innovation and creativity in turbulent business environments. However, the literature has not investigated the question of how coaching and mentoring are interrelated. By examining this connection, this study explores the joint effects of these practices on the organizational commitment of employees. The results from survey data of 247 employees, who were coachees as well as protégés at the same time, from 17 companies in South Korea suggested that mentoring moderates the positive relationship between managerial coaching and organizational commitment. In addition, the moderating effects also depended on the extent of the homogeneity of their coach and mentor. The positive relationship between managerial coaching and organizational commitment strongly increased with conditions of higher mentoring and lower homogeneity of coach and mentor. Conversely, the relationship became negative when both mentoring practice and the homogeneity of coach and mentor were low. These results could provide practical implications to organizations that are concurrently adopting both coaching and mentoring programs by helping managers to better understand their joint effects.

  12. The relationship between hospital managers' leadership style and effectiveness with passing managerial training courses.

    Science.gov (United States)

    Saleh Ardestani, Abbas; Sarabi Asiabar, Ali; Ebadifard Azar, Farbod; Abtahi, Seyyed Ali

    2016-01-01

    Background: Effective leadership that rises from managerial training courses is highly constructive in managing hospitals more effectively. This study aims at investigating the relationship between leadership effectiveness with providing management training courses for hospital managers. Methods: This was a cross-sectional study carried out on top and middle managers of 16 hospitals of Iran University of Medical Sciences. As a sample, 96 participants were selected through census method. Data were collected using leadership effectiveness and style questionnaire, whose validity and reliability were certified in previous studies. Pearson correlation coefficient and linear regressions were used for data analysis. Results: Leadership effectiveness score was estimated to be 4.36, showing a suitable status for managers' leadership effectiveness compared to the set criteria. No significant difference was found between leadership effectiveness and styles among managers who had passed the training courses with those who had not (p>0.05). Conclusion: Passing managerial training courses may have no significant effect on managers' leadership effectiveness, but there may be some other variables which should be meticulously studied.

  13. End of an era? Managerial losses of African American and Latinos in the public sector.

    Science.gov (United States)

    Wilson, George; Roscigno, Vincent

    2015-11-01

    In this article, we examine whether "new governance" reforms in public sector work over the last two decades have generated managerial wage losses for African Americans and Latinos. Findings from Integrated Public Use Micro-Series data across three time points indicate that the new "business logic" encompassing, most notably, increased employer discretion has progressively disadvantaged African American and Latino men and women relative to their White and gender counterparts. Indeed, for both African Americans and Latinos in the managerial ranks, relative parity in wages that were witnessed in the public sector progressively eroded between 2000 and 2010. Qualifications to these findings indicate that levels of inequality become pronounced for African Americans, and more so among men than women. We discuss the historical niche status of public sector work for racial and ethnic minorities in the U.S. and the importance of conducting further analyses of the public sector because of its fluid nature as a locus of racial stratification. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. The Managerial Reduction in the Management Technologies Transposition Process to Public Organizations

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    Sandro Trescastro Bergue

    2010-04-01

    Full Text Available This essay discusses the phenomenon of the implementation of technologies designed in the management business, with emphasis on relations with public organizations. It proposes a reflection on the concept of sociological reduction by Guerreiro Ramos, recovering its roots in Husserl and Heidegger and their relationship with the concepts of creative adaptation and the translation of managerial issues. Contextualized in the paradigm of new public management and the list of values and assumptions on which this movement is based, the analysis of the reproduction of practices known in private organizations by public ones seeking their legitimacy has revealed the formality and ceremonial aspect of this contemporary phenomenon. The importance of bringing knowledge from the organizational field that subsidizes management as well as the coherence of these cultural objects in terms of concepts and assumptions of organization are highlighted here. The process of transpositions, contrasting with reproducible traits of Brazilian managerial culture that are historically constructed but consistent with the notion of sociological reduction, requires a critical, conscious and engaged attitude on the part of members of the organization not only regarding the relevance of the imported content but also giving new meaning to the concepts underlying the management technologies.

  15. Letting go of Managing? Struggles over Managerial Roles in Collaborative Governance

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    Mie Plotnikof

    2016-03-01

    Full Text Available This article discusses the role of the manager in collaborative governance studies. These studies identify a new managerial role as facilitator of stakeholder collaboration when pursuing public policy and service innovation. But the complications of role changes are underexplored; hence this article addresses the emerging challenges. Drawing on organizational discourse studies, it theorizes and analyzes managers’ positioning during collaborative governance practices in cases from the Danish daycare area. The findings demonstrate how public managers construct old and new roles related to various public management discourses, and their struggles to change accordingly. However, the findings also show how managers empower their new role and gain agency to steer collaborative outcomes. Thereby the article unpacks the challenges of becoming a facilitating manager alongside other roles: the struggles of identity and agency constitutive to particular ways of managing, as well as struggles over multiple roles. It suggests paying greater attention to constitutive aspects of changing roles to understand the managerial challenges and effects implied through emerging public management discourses.

  16. Midlife managerial experience is linked to late life hippocampal morphology and function.

    Science.gov (United States)

    Suo, C; Gates, N; Fiatarone Singh, M; Saigal, N; Wilson, G C; Meiklejohn, J; Sachdev, P; Brodaty, H; Wen, W; Singh, N; Baune, B T; Baker, M; Foroughi, N; Wang, Y; Valenzuela, Michael J

    2017-04-01

    An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation.

  17. Health among Swedish employees and financial situation, education, and managerial responsibility: a longitudinal study.

    Science.gov (United States)

    Runeson, Roma; Vingård, Eva; Lampa, Erik; Wahlstedt, Kurt

    2012-11-01

    The present study is part of a 3-year longitudinal study on work and health among employees in the public sector in Sweden. The aim was to study associations between self-rated health (SRH) and financial situation, education, and managerial responsibility. Of the 9003 employees, 7533 answered the baseline questionnaires (84%). Altogether 9373 subjects received the follow-up questionnaire, and 6617 subjects responded (71%). In total 4240 completed the questionnaire on both occasions, and this group comprised the study population. SRH consisted of the response to a single question: 'In general, would you say your health is excellent, very good, good, poor, or very poor?' The health was investigated in terms of the development of health status in the 3-year follow-up. The exposure factors were: financial situation, education, and managerial responsibility. Odds ratios were analysed using logistic regressions. Good financial situation and further education were predictors in maintaining good health and in avoiding poor health. The analysis also indicated the following determinants of sustained good SRH: having a good financial situation (OR 1.99 at baseline and OR 1.87 at follow-up), having a further education compared to lower education (OR 1.17 at baseline), and not having a worsening financial situation between baseline and follow-up (OR 0.53). Financial situation and educational level were important factors that influence the subjective perception of health.

  18. THE FEATURES OF THE PROCESS OF MANAGERIAL DECISION-MAKING IN THE ENTERPRISE

    Directory of Open Access Journals (Sweden)

    E. V. Romanovskaya

    2015-01-01

    Full Text Available The article discusses issues related to the development and acceptance of administrative decisions in the enterprise. The large number of publications in the field of research of the process of managerial decision-making demonstrates its relevance for effective management of the enterprise. The article presents the author's approach to the disclosure of the nature and concepts of the term «management decision», a substantive analysis of the main elements of the theoretical aspect of managerial decision-making. The increased competition associated with market liberalization and globalization of world economy, requires from senior management of an effective control system. The authors revised classification criteria and allocated them accordingly the kinds of management decisions; identifies the main stages of development and adoption of management decisions. The article is devoted to finding new ways of making decisions to improve the efficiency of enterprise management. It is noted that for optimal decision making, it is required to calculate the impact of its implementation on the value of the enterprise as a whole or the size of its economic effect.

  19. Relation of managerial efficiency and leadership styles – Empirical study in Hrvatska elektroprivreda d.d.

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    Damir Skansi

    2000-01-01

    Full Text Available The relation of the managerial efficiency and leadership styles are analysed in this paper. We conducted an empirical study in a Croatian power supply company (HEP. The dominant leadership style in HEP is consultational, which the organization, according to postulates of this research, brings closer to the top global companies, considering that the tendencies in leadership styles point to the need for a new generation of leaders which will be essentially different from the traditional manager. We have determined that there is a significant interdependence between leadership styles of HEP’s managers (measured using Likert’s method and the degree of management work efficiency (measured using the adjusted Mott’s technique; the closer the leadership style is to System 4, that is participational, the higher the managerial efficiency is. Also, we have found that there is no significant difference between lower and middle management in HEP, concerning the relation between leadership styles and efficiency. This means that both levels get better grades for its efficiency if they belong to a consultational and participational leadership style.

  20. The Impact of Technology, Job Complexity and Religious Orientation on Managerial Performance

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    Jesmin Islam

    2011-12-01

    Full Text Available This paper explores the impact of technology, job complexity and religious orientation on the performance of managers in the financial services industries. Data were collected from bank managers representing Islamic and conventional banks in Bangladesh. Path models were used to analyse the data. The results provide supportfor the hypothesis that a management accounting systems (MAS adequacy gap exists in the financial sector in a developing country such as Bangladesh. These Islamic and conventional banks also experienced varied outcomes regarding the impact of the MAS adequacy gap on managerial effectiveness. Significant results emerged concerning the direct influence of technology and job complexity on managerial effectiveness, although these findings again differed across religious and conventional banks. Significant intervening effects of both MAS adequacy gap and job complexity on the relationships between contingency factors and managers' effectiveness were also found. Overall the findings showed that the type of religious orientation in Islamic banks wielded an important influence on the sensitivity of the MAS adequacy gap. Religious orientation served as a control device for the relationships between job-related contingency factors andmanagerial effectiveness.

  1. Organic and conventional production in Slovakia: Comparison of selected managerial and financial indicators

    Directory of Open Access Journals (Sweden)

    Jana Kozáková

    2014-11-01

    Full Text Available The paper addresses the issue to compare organic and conventional agriculture from two points of view. Firstly the managerial point of view examing number of employees and the personal costs per hectare, secondly the owners' view examing profitability of organic farming. Both views result from the specifics of organic farming. Organic production should generate higher employment, higher personal cost and results in lower yields. We evaluated differences between organic and conventional farms in Slovakia over period of years 2009-2012 on a sample of more than 1050 farms in each year. The share of organic farms was 15%. Using t-test as evaluation method we found no significant differences from the managerial point of view (measured by employees per hectare and personal costs per hectare. From the owner' s point of view (measured by return on costs, return on equity and total assets per hectare we conclude that the subsidies successfully compensate the lower revenues of organic farms (there was no significant difference in ROE and ROC. Our results are based on the sample of organic farms with Average utilised area of 850 hectares and reflect the farm structure in Slovakia. We can conclude that large organic farms do not support employment in rural areas and generate comparable profit when compared to conventional farming.

  2. Managerial Opportunism: Monitoring Financial Risk of Malaysian Shariah-compliant Companies

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    Aziatul Waznah Ghazali

    2018-01-01

    Full Text Available Managerial opportunism, such as earnings management, is a rampant, but often discreet, among certain managers. Agency theory and the notion of conflict of interest are used as bases to assume that managers would resolve to engage with inappropriate activities for their personal benefits. Distortion of earnings would erode investor confidence and is detrimental to the capital market. The Islamic capital market with Shariah-compliant firms is expected not to engage in activities that go against the religion code of conduct. The main purpose of this study is to investigate managerial opportunism among Shariah-compliant companies, specifically the relationship between real earnings management and the risk of financial distress, leverage, and free cash flow. This study employs 4,115 data from 694 sample companies for five years (2009–2013. Findings conclude that the risk of financial distress, leverage, and free cash flow have a significant relationship with earnings management among Shariah-compliant companies. This study provides evidence that further improvements on corporate governance are necessary to ensure that Shariah-compliant companies adhere with the Shariah requirement.

  3. Managerial optimism and the impact of cash flow sensitivity on corporate investment: The case of Greece

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    Dimitrios I. Maditinos

    2015-10-01

    Full Text Available Purpose - The existence of optimism as a personal psychological characteristic of managers is a necessity in contemporary economy and decision making, although the phenomenon of over-optimism may lead to unfavourable outcomes. The purpose of this study is to examine the optimism bias and its impact on the firms' future performance. Especially regarding the recent years where Greece faces increased economic depression, high percentages of unemployment and lack of budgetary discipline, the goal is therefore, to find whether managerial optimism has an impact on corporate investment of Greek firms. Design/methodology/approach - The investment of firms with optimistic managers is more sensitive to cash flow than the investment of firms with managers who are not optimistic. To test the research question a number of fixed effect panel regressions of capital expenditures (capital expenditures divided by lagged assets is the dependent variable is run. In all regressions we analyse cash flow divided by lagged assets and lagged Tobin's Q as the independent variables, for firms whose managers are classified as optimistic and not optimistic. This classification is based on the optimism "dummy" variable, which is equal to 1 when members of the Executive Board and the Supervisory Board (ALL, only the Executive Board (EB, and only CEO are classified as optimistic. The concept of this study is tested for firms which are listed in the Athens Stock Exchange. A total of 243 firms are recorded, for the time period between 2007 and 2012, including firms from 11 different industries; basic materials, chemicals, consumer goods, consumer services, health care, industrials, financials, oil and gas, technology, telecommunications and utilities. Based on the literature and on related methodology aspects, financial firms are excluded. Findings - It was revealed that managerial optimism affects corporate investment in firms with high degree of closely held shares. Moreover

  4. The Moderating Effect of Procedural Justice on the Effectiveness of the Balanced Scorecard in Improving Managerial Performance through Organizational Commitment

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    Supriyadi Supriyadi

    2010-09-01

    Full Text Available This study extends prior studies on the effectiveness of theBalanced Scorecard (BSC to improve managerial performancedone by Lau and Mosser (2008 and Lau and Sholihin (2005.Specifically, the study empirically tests the moderating effects ofprocedural justice on the relationship between the financial andnonfinancial dimensions of BSC and managerial performance. Italso tests the impact of organizational commitment on performance.Based on survey data from 76 respondents, the results indicate thatperceived procedural justice in the use financial and nonfinancialdimensions of the BSC is associated with managers’ organizationalcommitment. It further finds that organizational commitment ispositively related to performance. The study extends the literatureby providing empirical evidence about the moderating effect ofprocedural justice on the relationship between the financial andnonfinancial dimensions of BSC and organizational commitment. Keywords: balanced scorecard; organizational commitment; financial measures;managerial performance; moderating effect; nonfinancial measures;procedural justice

  5. A Bridge Over Turbulent Waters: Illustrating the Interaction Between Managerial Leaders and Facilitators When Implementing Research Evidence.

    Science.gov (United States)

    van der Zijpp, Teatske Johanna; Niessen, Theo; Eldh, Ann Catrine; Hawkes, Claire; McMullan, Christel; Mockford, Carole; Wallin, Lars; McCormack, Brendan; Rycroft-Malone, Jo; Seers, Kate

    2016-02-01

    Emerging evidence focuses on the importance of the role of leadership in successfully transferring research evidence into practice. However, little is known about the interaction between managerial leaders and clinical leaders acting as facilitators (internal facilitators [IFs]) in this implementation process. To describe the interaction between managerial leaders and IFs and how this enabled or hindered the facilitation process of implementing urinary incontinence guideline recommendations in a local context in settings that provide long-term care to older people. Semistructured interviews with 105 managers and 22 IFs, collected for a realist process evaluation across four European countries informed this study. An interpretive data analysis unpacks interactions between managerial leaders and IFs. This study identified three themes that were important in the interactions between managerial leaders and IFs that could hinder or support the implementation process: "realising commitment"; "negotiating conditions"; and "encouragement to keep momentum going." The findings revealed that the continuous reciprocal relationships between IFs and managerial leaders influenced the progress of implementation, and could slow the process down or disrupt it. A metaphor of crossing a turbulent river by the "building of a bridge" emerged as one way of understanding the findings. Our findings illuminate a neglected area, the effects of relationships between key staff on implementing evidence into practice. Relational aspects of managerial and clinical leadership roles need greater consideration when planning guideline implementation and practice change. In order to support implementation, staff assigned as IFs as well as stakeholders like managers at all levels of an organisation should be engaged in realising commitment, negotiating conditions, and keeping momentum going. Thus, communication is crucial between all involved. © 2016 Sigma Theta Tau International.

  6. Career histories and managerial performance of health care chief executive officers: an empirical study in the Italian National Health Service.

    Science.gov (United States)

    Mascia, Daniele; Piconi, Ilaria

    2013-01-01

    Organizational studies widely acknowledge the importance of the relationship between CEO's career histories and managerial performance. Although the health care management literature largely explores the role of CEOs, whether and how top managers' career histories affect their own performance remains still unknown in this industry. The aim of this study was to investigate the career histories of health care CEOs and to explore their impact on managerial performance. Primary data were collected from a sample of 124 CEOs leading health care organizations in the Italian National Health Service in 2008. Biographic data were accessed to gather information about relevant CEOs' demographics and their career histories. The relevance of CEOs' prior experience was considered, taking into account the prominence of health care organizations in which they passed through in their career histories. Regression analyses were employed to assess the impact of CEOs' career histories on their managerial performance. Top managers already appointed as CEOs were more likely to achieve higher levels of performance. Careers with long tenure within the National Health Service appear to increase managerial performance. Those CEOs who accumulated prior experience in a large number of health care structures and who spent time working at the most prominent hospitals were also more likely to achieve higher levels of managerial performance. In health care, a CEO's career history does impact his or her managerial performance. Specifically, patterns of career that imply higher mobility across health care organizations are important. Although interorganizational mobility is significant for CEO performance, the same does not hold for mobility across industries. These findings contribute to the current debate about the need for management renovation within health care organizations.

  7. A grounded exploration of the dimensions of managerial capability: A preliminary study of top Australian pharmacist owner-managers.

    Science.gov (United States)

    Woods, Phillip; Gapp, Rod; King, Michelle A

    2015-01-01

    Australian community pharmacies are experiencing challenges, including government prescription pricing reform and a dramatically increasing competitive environment. Enacting appropriate responsive actions requires capable pharmacy managers. 'Capability' implies managing effectively in the present, but with unknown or emerging contexts and with new problems. A conceptual understanding of managerial capability as practiced by pharmacist owner-managers is unavailable in the literature. This research aimed to address the question: How can we understand managerial capability in relation to effective community pharmacy management? The study's objective was to develop preliminary theoretical departure points for continuing research responding to the research question. The objective was approached by exploring how 5 top Australian pharmacy owner-managers accomplish the management of their businesses in a changing business environment. Qualitative research methods were employed to develop a social process perspective of how the managers enact their management practices. In-depth semi-structured life-world interviews were undertaken as the major method of data collection. Interview text thematic analysis was carried out identifying rich conceptual properties and dimensions, which 'dimensionalized' 3 key integrated categories. The findings show how the managers are immersed in their business, managerial and personal practices in a holistic and relational manner. Managerial processes, reported through three conceptual categories, their properties and dimensions, reveal the highly situational nature of the reality the managers were experiencing, including their need to express their personal/professional identity. The properties and dimensions of the category 'learning generatively' in particular, reveal how the pharmacy owner-managers shape their business activities and their emerging context as time passes. The preliminary interpretive view of managerial capability describes

  8. Cognitive requirements of competing neuro-behavioral decision systems: some implications of temporal horizon for managerial behavior in organizations.

    Science.gov (United States)

    Foxall, Gordon R

    2014-01-01

    Interpretation of managerial activity in terms of neuroscience is typically concerned with extreme behaviors such as corporate fraud or reckless investment (Peterson, 2007; Wargo et al., 2010a). This paper is concerned to map out the neurophysiological and cognitive mechanisms at work across the spectrum of managerial behaviors encountered in more day-to-day contexts. It proposes that the competing neuro-behavioral decisions systems (CNBDS) hypothesis (Bickel et al., 2012b) captures well the range of managerial behaviors that can be characterized as hyper- or hypo-activity in either the limbically-based impulsive system or the frontal-cortically based executive system with the corresponding level of activity encountered in the alternative brain region. This pattern of neurophysiological responding also features in the Somatic Marker Hypothesis (Damasio, 1994) and in Reinforcement Sensitivity Theory (RST; Gray and McNaughton, 2000; McNaughton and Corr, 2004), which usefully extend the thesis, for example in the direction of personality. In discussing these theories, the paper has three purposes: to clarify the role of cognitive explanation in neuro-behavioral decision theory, to propose picoeconomics (Ainslie, 1992) as the cognitive component of competing neuro-behavioral decision systems theory and to suggest solutions to the problems of imbalanced neurophysiological activity in managerial behavior. The first is accomplished through discussion of the role of picoeconomics in neuro-behavioral decision theory; the second, by consideration of adaptive-innovative cognitive styles (Kirton, 2003) in the construction of managerial teams, a theme that can now be investigated by a dedicated research program that incorporates psychometric analysis of personality types and cognitive styles involved in managerial decision-making and the underlying neurophysiological bases of such decision-making.

  9. Cognitive requirements of competing neuro-behavioral decision systems: Some implications of temporal horizon for managerial behavior in organizations

    Directory of Open Access Journals (Sweden)

    Gordon Robert Foxall

    2014-04-01

    Full Text Available Interpretation of managerial activity in terms of neuroscience is typically concerned with extreme behaviors such as corporate fraud or reckless investment (Wargo, Baglini & Nelson, 2010a; Peterson, 2007. This paper is concerned to map out the neurophysiological and cognitive mechanisms at work across the spectrum of managerial behaviors encountered in more day-to-day contexts. It proposes that the competing neuro-behavioral decisions systems (CNBDS hypothesis (Bickel, Mueller & Jarmolowicz, 2012 captures well the range of managerial behaviors that can be characterized as hyper- or hypo-activity in either the limbically-based impulsive system or the frontal-cortically based executive system with the corresponding level of activity encountered in the alternative brain region. This pattern of neurophysiological responding also features in the Somatic Marker Hypothesis (Damasio, 1994 and in Reinforcement Sensitivity Theory (Gray & McNaughton, 2000; McNaughton & Corr, 2004, which usefully extend the thesis, for example in the direction of personality. In discussing these theories, the paper has three purposes: to clarify the role of cognitive explanation in neuro-behavioral decision theory, to propose picoeconomics (Ainslie, 1992 as the cognitive component of competing neuro-behavioral decision systems theory and to suggest solutions to the problems of imbalanced neurophysiological activity in managerial behaviour. The first is accomplished through discussion of the role of picoeconomics in neuro-behavioral decision theory; the second, by consideration of adaptive-innovative cognitive styles (Kirton, 2003 in the construction of managerial teams, a theme that can now be investigated by a dedicated research program that incorporates psychometric analysis of personality types and cognitive styles involved in managerial decision-making and the underlying neurophysiological bases of such decision-making.

  10. ISSUES REGARDING THE MANAGEMENT OF INTERNAL CONTROL/ MANAGERIAL AND COMBATING SOME NEGATIVE EFFECTS IN ROMANIAN PUBLIC INSTITUTIONS' ACTIVITY

    Directory of Open Access Journals (Sweden)

    Ion Stegaroiu

    2015-05-01

    Full Text Available The paper aims to analyze the importance and impact of the management of internal control/ managerial in Romanian public institutions, as well as the consequences arising as a result of not implementing it. It also analyzed the legal framework governing the internal control/managerial and the main conclusions issued by the Romanian Court of Accounts on the status of its implementation in Romanian public institutions. At the same time, it is stressed the role of management carried out by heads of public institutions in terms of combating the negative effects that have a direct impact on their activity.

  11. The Impact of the Electronic Payment System on the Development of Nowadays Society: an Economic and a Managerial Perspective

    Directory of Open Access Journals (Sweden)

    Cristina Raluca Popescu

    2015-12-01

    Full Text Available The paper “The Impact of the Electronic Payment System on the Development of Nowadays Society: an Economic and a Managerial Perspective” presents the aspects concerning the impact of the electronic payment system on the development of nowadays society as an economic and a managerial perspective. Our research focuses on issues related to the payments sector, the Smartcard, the Electronic Banking,payment systems based on bank cards, the Cyber cash, and the electronic payment systems (1 Net Cash and (2 E-Cash, Micro-payment systems with (1 Millicent and (2 Cyber Coin, as well as the electronic check payments.

  12. Comparisons of self-ratings on managerial competencies, research capability, time management, executive power, workload and work stress among nurse administrators.

    Science.gov (United States)

    Kang, Chun-Mei; Chiu, Hsiao-Ting; Hu, Yi-Chun; Chen, Hsiao-Lien; Lee, Pi-Hsia; Chang, Wen-Yin

    2012-10-01

    To assess the level of and the differences in managerial competencies, research capability, time management, executive power, workload and work-stress ratings among nurse administrators (NAs), and to determine the best predictors of managerial competencies for NAs. Although NAs require multifaceted managerial competencies, research related to NAs' managerial competencies is limited. A cross-sectional survey was conducted with 330 NAs from 16 acute care hospitals. Managerial competencies were determined through a self-developed questionnaire. Data were collected in 2011. All NAs gave themselves the highest rating on integrity and the lowest on both financial/budgeting and business acumen. All scores for managerial competencies, research capability, time management and executive power showed a statistically significant correlation. The stepwise regression analysis revealed that age; having received NA training; having completed a nursing project independently; and scores for research capability, executive power and workload could explain 63.2% of the total variance in managerial competencies. The present study provides recommendations for future administrative training programmes to increase NAs' managerial competency in fulfilling their management roles and functions. The findings inform leaders of hospitals where NAs need to develop additional competencies concerning the type of training NAs need to function proficiently. © 2012 Blackwell Publishing Ltd.

  13. The Role of Formal Education, Technical and Management Training on Information Systems (IS) Managers' Managerial Effectiveness as Perceived by Their Subordinates

    Science.gov (United States)

    Ligon, Jerry; Abdullah, ABM; Talukder, Majharul

    2007-01-01

    This study examined the relationship between Information Systems (IS) managers' formal education, level of technical and managerial training and their managerial effectiveness as perceived by their subordinates. The study finds that there is a strong positive relationship between the amount of technical training IS managers have received and their…

  14. Green, Innovative, and Profitable: A Case Study of Managerial Capabilities at Interface Inc.

    Directory of Open Access Journals (Sweden)

    Tommi Lampikoski

    2012-11-01

    Full Text Available This article describes the pioneering green-innovation management practices of a resource-intensive corporation, Interface Inc., which is a globally operating carpet manufacturer. Even during the current economic downturn, many companies remain committed to advancing their green business agendas. However, recent research suggests that most of these companies are far from reaching substantial competitive advantage from this commitment because they lack the connection between their green agendas and core innovation-management activities. This study illustrates how Interface succeeded with radical green innovations by investing in managerial capabilities that allowed it to conduct research, recognize opportunities, and revolutionize the carpeting industry. These capabilities enabled Interface to continuously challenge and disrupt well-established management recipes, existing knowledge, and proven industrial practices, and they enabled it to create a sustainable competitive advantage through a winning portfolio of radical green innovations.

  15. Pengaruh Penggantian Manajemen, Dewan Komisaris Independen, Kepemilikan Managerial, Kepemilikan Institusional, dan Kualitas Audit Terhadap Manajemen Laba

    Directory of Open Access Journals (Sweden)

    Andan Yunianto

    2016-03-01

    Full Text Available The purpose of this study is to find out empirical evidence that the management turnover positively affects the earnings management and composition of independent board of director, managerial ownership, institutional ownership, and the quality of auditing negatively affect the earnings management, which is measured by using an absolute discretionary accrual. Sample of the study is consisted of 76 firms with 166 firm years from panel data of all manufacturing companies listed in the Indonesian Stock Exchange from 2006 to 2009. The study uses an ordinary least square regression to test hypotheses proposed. Result of the study indicates that the management turnover, composition of independent board of director and institutional ownership did not affect the earnings management, while the quality of auditing positively affects the earnings management.

  16. A Behavioral Model of Managerial Perspectives Regarding Technology Acceptance in Building Energy Management Systems

    Directory of Open Access Journals (Sweden)

    Jacky Chin

    2016-07-01

    Full Text Available The Building Energy Management System (BEMS, a well-known system that has been implemented in some energy corporations, has become attractive to many companies seeking to better monitor their energy consumption efficiency. This study investigated the external factors that influence acceptance of the BEMS from managerial perspectives. An extended model based on the Technology Acceptance Model (TAM was created to evaluate the implementation of the BEMS in the manufacturing industries. A structural equation modeling (SEM approach was used to analyze the model by adopting compatibility, features, technology complexity, and perceived risk as the external variables, and integrating the five dimensions of perceived ease of use, perceived usefulness, attitude, user satisfaction, and behavioral intention. The analysis results indicated that the external factors positively influenced users’ behavioral intention to use the BEMS through expected satisfaction, perceived ease of use, and perceived usefulness. Suggestions for BEMS developers are provided as well.

  17. The environmental education from the perspective of the managerial social responsibility

    Directory of Open Access Journals (Sweden)

    Segundo Javier Reyes-Solórzano

    2018-02-01

    Full Text Available In the last two decades the concern for the environment in the organizational context has been growing demanding that the companies respect the environment for a sustainable development, this acquires it special relevance with the Managerial Social Responsibility, where the economic, social and environmental aspects are constituted in synthesis of the organizational ecological values. This reality imposes a necessity and a challenge: the environmental education, element that not alone it will guide the training in the company but rather it will project their activities toward the community for the solution of the environmental problems. For this, the relationship of the company and the community should propitiate the integration of the educational purposes of each one toward the adaptation and adjustment of the environmental problem, at the time that also promotes the potentialities to change and to transform the environment creatively.

  18. Cost analysis and the practicing radiologist/manager: an introduction to managerial accounting.

    Science.gov (United States)

    Forman, H P; Yin, D

    1996-06-01

    Cost analysis is inherently one of the most tedious tasks falling on the shoulders of any manager. In today's world, whether in a service business such as radiology or medicine or in a product line such as car manufacturing, accurate cost analysis is critical to all aspects of management: marketing, competitive strategy, quality control, human resource management, accounting (financial), and operations management, to name but a few. This is a topic that we will explore with the intention of giving the radiologist/manager the understanding and the basic skills to use cost analysis efficiently, making sure that major financial decisions are being made with adequate cost information, and showing that cost accounting is really managerial accounting in that it pays little attention to the bottom line of financial statements but places much more emphasis on equipping managers with the information to determine budgets, prices, salaries, and incentives and influences capital budgeting decisions through an understanding of product profitability rather than firm profitability.

  19. 'Following the word of God': Empirical insights into managerial perceptions on spirituality, culture and health.

    Science.gov (United States)

    Mayer, Claude-Hélène; Viviers, Rian

    2014-06-01

    This article focuses on managers in a selected South African organization and the connections they draw between mental health, culture and spirituality within the workplace. The aim is to gain a deeper understanding of the interrelationships in this complex and growing scientific discourse and to respond to the research question of how mental health, culture and spirituality are interrelated from a managerial perspective. The study follows an inductive single case study approach within the phenomenological paradigm. Qualitative research methods using in-depth interviews and observation were used. The sample comprised 27 managers within the international South African automotive organization. The findings show that not only culture, but also spirituality and religion in particular, influence mental health and well-being of managers at work. Conclusions are drawn and recommendations made.

  20. Women's access to managerial positions: an experimental study of leadership styles and gender.

    Science.gov (United States)

    Cuadrado, Isabel; Morales, J Francisco; Recio, Patricia

    2008-05-01

    This study attempts to test one of the explanations of the scarce representation of women in managerial positions, specifically the one advanced by "role congruity theory of prejudice toward female leaders" (Eagly & Karau, 2002), which appeals to the fact that women get unfavorable evaluations if they adopt male-stereotypical leadership styles. One-hundred and thirty-six undergraduate students participated in an experiment with a 2 (Male-stereotypical vs. Female-stereotypical leadership style) x 2 (Male vs. Female leader) design. Dependent variables were leader's competence, efficacy, and evaluation in a series of traits. It was found that, regardless of sex, the leaders were considered more competent and efficient, and were evaluated more favorably, when they adopted stereotypically feminine leadership styles. Implications of these findings for women's underrepresentation as leaders in management top positions worldwide are discussed.

  1. The managerial issues related to transferring shop floor knowledge in manufacturing relocation

    DEFF Research Database (Denmark)

    Knudsen, Mette Præst; Madsen, Erik Skov

    2014-01-01

    Purpose – The purpose of this paper is to explore the specific practices of management in the dispatching unit and to identify mechanisms for supporting transfer of shop floor knowledge embedded in operating manufacturing equipment. Design/methodology/approach – The paper applies an inductive...... and a case study approach for exploring three empirical cases that represent different manufacturing facility relocation processes and differences in the applied managerial practices. Findings – The paper identifies two important gaps in international production literature when firms relocate equipment...... to other sites; a time gap (from dismantling to re-assembly of production facilities) and a space gap (from the current to the new site abroad). These gaps are important for understanding why relocation processes are difficult and what management can do to facilitate such processes. Practical implications...

  2. The fundamental managerial challenges in the role of a contemporary district nurse: A discussion.

    Science.gov (United States)

    McComiskey, Florence

    2017-10-02

    This article examines some of the fundamental challenges facing the district nurse in delivery of the managerial aspects of her role in contemporary practice. It discusses the personal attributes that are essential for this role to ensure safe, effective and compassionate leadership and management. The communication skills and ethos underpinning collaborative multidiscilplinary team work and person-centred care are discussed. Issues that compromise positive and productive team working are identified, and strategies dealing with conflict and also change management are debated. These factors are interrelated with the everyday demands of caseload management, the development of educational needs to meet the demands of increased complexity in care needs, and the place of technology in modern health care. It is evidenced that sustained organisational support for this role is more important than ever, due to increasing demand and decreasing capacity. Potential solutions to these challenges are offered to assist the contemporary district nurse.

  3. UTILIZATION OF QUALITY MANAGERIAL SYSTEMS IN BUSINESS ENTITIES IN THE SLOVAK REPUBLIC

    Directory of Open Access Journals (Sweden)

    Zuzana Kapsdorferová

    2015-06-01

    Full Text Available Current global trends force businesses to enhance their competitiveness via quality, innovations, leaning of production processes and shortening of production cycles, development of employees and satisfying of customer's needs. At the same time, the society demands from entities more emphasis on sustainable development, environmental protection, social responsibility and on other social aspects of the business. Many firms seek the ways how to master such important demands and gain the recognition on the market. One of the avenues how to achieve planned results resides in implementation of the Total Quality Management systems, which also provide grounds for reaching a status of reliable business partner. Presented research paper puts an emphasis on execution of research in order to find out about the situation with the status of implementation of the quality managerial systems in Slovak businesses as well as to recognize reasons and contributions of usage of these systems in their activities.

  4. Sustainable Entrepreneurship Orientation: A Reflection on Status-Quo Research on Factors Facilitating Responsible Managerial Practices

    Directory of Open Access Journals (Sweden)

    Sascha Kraus

    2018-02-01

    Full Text Available With the global financial system having undergone vast changes since the financial crisis of 2007, scientific research concerning the investor’s point of view on sustainable investments has drastically increased. However, there remains a lack of research focused on the entrepreneur’s angle regarding sustainable oriented investments. The aim of this paper is to contribute to the understanding of sustainable financial markets by bringing together entrepreneurial and financial research. This paper provides a structured literature review, based on which the authors identify three relevant levels that they believe have an effect on the successful implementation of managerial sustainable practices; these are the individual, the firm, and the contextual levels. The results show that on the individual level sustainable entrepreneurs tend to derive their will to act more sustainably from their personal values or traits. On the organizational level, though, it can be concluded that an small and medium sized enterprise’s internal culture and the reconfiguration of resources are critical determinants for adopting a sustainable entrepreneurial orientation. Finally, on the contextual level, researchers have focused on a better understanding of how entrepreneurs can help society and the environment through sustainable entrepreneurship, and how they can act as role models or change agents in light of the fact that the choice of investing or financing based on sustainability is still in its infancy. By providing an overview on facilitating factors for responsible managerial practices on the entrepreneur’s side, this research contributes to a better understanding for both theory and practice on how sustainable practices can be implemented and facilitated.

  5. Evaluation of Managerial Needs for Palliative Care Centers: Perspectives of Medical Directors.

    Science.gov (United States)

    Kafadar, Didem; Ince, Nurhan; Akcakaya, Adem; Gumus, Mahmut

    2015-01-01

    Palliative therapies have an important role in increasing the quality of healthcare and in dealing with physical and psychosocial problems due to cancer. We here aimed to evaluate the managerial perspectives and opinions of the hospital managers and clinical directors about specialized palliative care centers. This study was conducted in two large-scale hospitals in which oncology care is given with medical directors (n:70). A questionnaire developed by the researchers asking about demographic characteristics and professional experience, opinions and suggestions of medical directors about providing and integrating palliative care into healthcare was used and responses were analyzed. Potential barriers in providing palliative care (PC) and integrating PC into health systems were perceived as institutional by most of the doctors (97%) and nurses (96%). Social barriers were reported by 54% of doctors and 82% of nurses. Barriers due to interest and knowledge of health professionals about PC were reported by 76% of doctors and 75% of nurses. Among encouragement ideas to provide PC were dealing with staff educational needs (72%), improved working conditions (77%) and establishing a special PC unit (49)%. An independent PC unit was suggested by 27.7% of participants and there was no difference between the hospitals. To overcome the barriers for integration of PC into health systems, providing education for health professionals and patient relatives, raising awareness in society, financial arrangements and providing infrastructure were suggested. The necessity for planning and programming were emphasized. In our study, the opinions and perspectives of hospital managers and clinical directors were similar to current approaches. Managerial needs for treating cancer in efficient cancer centers, increasing the capacity of health professionals to provide care in every stage of cancer, effective education planning and patient care management were emphasized.

  6. Leadership effectiveness in Higher Education: Managerial self-perceptions versus perceptions of others

    Directory of Open Access Journals (Sweden)

    Tessie H.H. Herbst

    2011-03-01

    Research purpose: The purpose of this study was to investigate the prevalence of selfperception accuracy amongst the managers and to explore the patterns of interaction between self-perception accuracy (regarding their leadership behaviour and perceived transformational leadership behaviour (as measured by composite ‘other’-ratings. Motivation of the study: Research has shown that managers in various work environments typically overestimate their own level of competence and that this could impact on the effectiveness of their leadership behaviour. This phenomenon has however not yet been researched in the context of South African higher education institutions. Research design, approach and method: A quantitative cross-sectional study of the relationship between self-perception accuracy and leadership effectiveness was conducted amongst the total population (N = 204 of staff members in management positions. The response rate was 67% and the realised sample consisted of 137 managers. Leadership behaviour was measured by means of behavioural ratings on the following five dimensions of the Leadership Practices Inventory (LPI: ‘Challenging the process’, ‘Inspiring a shared vision’, ‘Enabling others to act’, ‘Modelling the way’ and ‘Encouraging the heart’. Main findings: Statistically significant discrepancies were found between self- and observer ratings on all five leadership dimensions, indicating a probable overestimation of their own capabilities. Results further provide evidence that perceived leadership effectiveness on three of the five transformational leadership practices varied as a function of the self-perceptions of managers. Practical/managerial implications: Managerial development practices should sensitise managers to what is essentially introspective and provide opportunities for them to reflect upon and question their leadership practices. Contribution/value-add: A challenge for higher education is to embark on feedback intensive

  7. The Impact of Managerial and Adaptive Capabilities to Stimulate Organizational Innovation in SMEs: A Complementary PLS–SEM Approach

    Directory of Open Access Journals (Sweden)

    Zulfiqar Ali

    2017-11-01

    Full Text Available The aim of this study is to empirically explore and propose a rigorous model for the positive impact of managerial capability (in terms of decision-making, management style, people development, and succession planning and adaptive capability (in terms of horizon scanning, change management, and resilience on organizational innovation in the context of small and medium-sized enterprises (SMEs. The study uses partial least squares structural equation modeling (PLS–SEM to test the model hypotheses, and importance-performance matrix analysis (IPMA to provide information regarding the significance and relevance of the dimensions of managerial and adaptive capability in explaining organizational innovation in the proposed model. The empirical data is gathered through questionnaires from 210 SMEs. The results show a strong and significant relationship between managerial capability, adaptive capability, and organizational innovation. This study found that all of the dimensions of managerial capability and adaptive capability help to develop and improve the performance of organizational innovation in SMEs. The study concludes with a comprehensive discussion of the research limitations, and provides suggestions for future research.

  8. Administrators' Managerial Competencies for Sustainable Human Resource Management in Secondary Education in Enugu State, Nigeria

    Science.gov (United States)

    Ezeugbor, Carol Obiageli; Victor, Akinfolarin Akinwale

    2018-01-01

    The inability of teachers to timely cover the scheme of work, students' truancy and persistent lateness to school, poor attitude towards teaching and learning, activities of cultism and frequent conflicts among secondary school students in Enugu State prompted this study to determine the administrators' managerial competencies for sustainable…

  9. Impact of Managerial Skills Learnt through MA Educational Planning Management Programme of AIOU on the Performance of Institutional Heads

    Science.gov (United States)

    Chuadhry, Muhammad Asif; Shah, Syed Manzoor Hussain

    2012-01-01

    Management provides formal coordination in an organization for achieving pre-determined goals. The educational manager particulary performs his duties by using different planning and management techniques. These techniques are equally important for the manager of other sectors. The present study was focused on the impact of managerial skills…

  10. The Fate of the Underclass in the Managerial Age: The Law of the Progressive Elimination of Surplus Population.

    Science.gov (United States)

    Darity, William, Jr.

    With a change in emphasis of our economy from heavy industry, such as steel, to a computer and electronics base, there has emerged a new managerial class of professionals in administrative and technical positions. The underlying motivation of this class is not the pursuit of profit, but rather control of the economy and establishment of a perfect…

  11. Perceptions of MBA Students towards Learning Climate for Managerial Knowledge: A Study of Business School in Lahore

    Science.gov (United States)

    Raza, Ahmad; Murad, Hasan; Kayani, Ashraf

    2010-01-01

    Purpose: The purpose of this paper is to explore different cultural dimensions of the learning climate at a business school located at Lahore, Pakistan. Design/methodology/approach: This paper reports the result of an empirical study of the learning climate for managerial knowledge at a business school, located in Lahore, Pakistan. A sample of 150…

  12. THE USE OF SOFTWARE SOLUTIONS FOR THE NEW GENERATION IN ORDER TO IMPROVE MANAGERIAL AND FINANCIAL ACCOUNTING AIRLINES

    Directory of Open Access Journals (Sweden)

    L. N. Voropaeva

    2014-01-01

    Full Text Available The paper gives a brief description of the possibilities of using the software-solutions of new generation enterprise resource planning (SAP ERP in order to improve managerial and financial accounting of the airline. The solution allows to automate the processes of accounting and management and to optimize the management of financial flows.

  13. The rise of the managerial state in Indonesia : institutional transition during the early independence period. 1950-1965

    NARCIS (Netherlands)

    Fakih, Farabi

    2014-01-01

    The dissertation analyzes the production of a new elite group in Indonesia, the managers, during the early independence period. Indonesia faced lack of expertise and a government incapable of managing a national plan. The expansion of the managerial class was the result of the lack of leadership of

  14. Factors Relating to Managerial Stereotypes : The Role of Gender of the Employee and the Manager and Management Gender Ratio

    NARCIS (Netherlands)

    Stoker, Janka I.; Van der Velde, Mandy; Lammers, Joris

    Several studies have shown that the traditional stereotype of a "good" manager being masculine and male still exists. The recent changes in the proportion of women and female managers in organizations could affect these two managerial stereotypes, leading to a stronger preference for feminine

  15. Effect of Principal Managerial Leadership and Compensation towards Physics Teacher Performance in Senior High School in Baguala District-Ambon

    Science.gov (United States)

    Wenno, Izaak Hendrik

    2017-01-01

    The performance of teachers is an important factor that must be considered in efforts to improve the quality of education. Teacher's performance is affected by many factors. Factors that affect the performance of teachers are principals' managerial leadership and compensation. The purpose of this study was to determine the effect of principals'…

  16. Designing and Using Projects with Real World Application in a MBA Managerial Accounting Class: The Case of The Balanced Scorecard

    Science.gov (United States)

    Houke, Charlotte

    2017-01-01

    This paper explores the purpose of designing and using projects with real world application in a M.B.A. managerial accounting class. Included is a discussion of how and why the Balanced Scorecard (BSC) Project has been used in classes to link theory with practice by providing real world application of the BSC framework. M.B.A. students represent a…

  17. All are equal, but some are more equal than others: Managerialism and gender equality in higher education in comparative perspective

    NARCIS (Netherlands)

    Teelken, J.C.; Deem, R.

    2013-01-01

    The main purpose of this paper is to investigate what impact new regimes of management and governance, including new managerialism, have had on perceptions of gender equality at universities in three Western European countries. While in accordance with national laws and EU directives, contemporary

  18. Structural and Psychological Empowerment Climates, Performance, and the Moderating Role of Shared Felt Accountability: A Managerial Perspective

    Science.gov (United States)

    Wallace, J. Craig; Johnson, Paul D.; Mathe, Kimberly; Paul, Jeff

    2011-01-01

    The authors proposed and tested a model in which data were collected from managers (n = 539) at 116 corporate-owned quick service restaurants to assess the structural and psychological empowerment process as moderated by shared-felt accountability on indices of performance from a managerial perspective. The authors found that empowering leadership…

  19. Understanding Managerial Problem-Solving, Knowledge Use and Information Processing: Investigating Stages from School to the Workplace

    Science.gov (United States)

    Arts, Jos A. R.; Gijselaers, Wim H.; Boshuizen, Henny P. A.

    2006-01-01

    The present study explores stages in managerial problem-solving skills of participants beginning with formal education, and continuing through the professional workplace setting. We studied nine different levels of expertise: from novice student groups, to graduates and expert groups. Participants were asked to diagnose and solve business cases.…

  20. Stability and change in teachers' goal orientation profiles over time : Managerial coaching behavior as a predictor of profile change

    NARCIS (Netherlands)

    Kunst, E.M.; van Woerkom, M.; van Kollenburg, G.H.; Poell, R.F.

    2018-01-01

    Goal orientation is an important predictor of motivation at work. This study introduces goal orientation profiles in the work domain, evaluates their stability over time and assesses the impact of managerial coaching behavior on change in employees' goal orientation profiles. We hypothesize that

  1. How Providing Mentoring Relates to Career Success and Organizational Commitment: A Study in the General Managerial Population

    Science.gov (United States)

    Bozionelos, Nikos; Bozionelos, Giorgos; Kostopoulos, Konstantinos; Polychroniou, Panagiotis

    2011-01-01

    Purpose: This study aims to investigate the relationship of mentoring provided with career success and organizational commitment in the general managerial population. Design/methodology/approach: Participants were 194 native British who were employed in a variety of jobs, professions and industries in the United Kingdom. Findings: Mentoring…

  2. Concepts Needed by Managerial Personnel in Automated Offices as Perceived by Office Systems Consultants and Collegiate Business Faculty.

    Science.gov (United States)

    Graves, Charlotte K.

    1985-01-01

    Office systems consultants, office administration faculty, and other collegiate business faculty (management, marketing, accounting, and finance) were asked to rate the importance of 42 concepts needed by managerial personnel in automated offices. Also, business faculty were asked to indicate which concepts were currently being taught in courses…

  3. 77 FR 61028 - Hasbro, Inc.; Hasbro Managerial Services, Inc., Including On-Site Leased Workers of Entegee East...

    Science.gov (United States)

    2012-10-05

    ... relevant period and that the subject firm had sufficient control over the leased workers for the Department to determine that there was operational control of the leased workers by the subject firm. The... Managerial Services, Inc., Including On-Site Leased Workers of Entegee East Longmeadow, MA Amended...

  4. The Construction of a Managerial Education Discourse and the Involvement of Philanthropic Entrepreneurs: The Case of Israel

    Science.gov (United States)

    Resnik, Julia

    2011-01-01

    Similar to many other countries, an educational reform anchored in a managerial discourse was proposed in Israel in 2004 by the Dovrat Committee, encouraged by the "inter-state education gap" social problem that economist Dan Ben-David formulated on the basis of international examinations, such as PISA and TIMMS. Through a neo-Weberian…

  5. Using FarmVille in an Introductory Managerial Accounting Course to Engage Students, Enhance Comprehension, and Develop Social Networking Skills

    Science.gov (United States)

    Krom, Cynthia L.

    2012-01-01

    This article explores the use of the free Zynga computer game FarmVille, which is played in conjunction with Facebook[R], to facilitate active learning in a managerial accounting course. Results indicate that it invokes an improved understanding of the accounting content, particularly among nonaccounting majors; a high level of student…

  6. Exploiting Managerial Capability for Innovation in a Micro-Firm Context: New and Emerging Perspectives within the Irish Hotel Industry

    Science.gov (United States)

    Kearney, Arthur; Harrington, Denis; Kelliher, Felicity

    2014-01-01

    Purpose: The paper has been developed from a critical review of available literature drawn from the micro firm, managerial capability and innovation management fields. The paper aims to address these issues. Design/methodology/approach: The paper has been developed from a critical review of available literature drawn from the micro firm,…

  7. What We Know and How We Know It: A Preliminary Study of Managerial Practices of High Schools in Shanghai.

    Science.gov (United States)

    Pang, Nicholas Sun-Keung

    The School Values Inventory (SVI) was used to examine teacher preferences concerning managerial practices of high schools in Shanghai. The SVI includes subscales of organizational values as formality, bureaucratic control, participation, collaboration, and teacher autonomy. When the 50-item instrument was administered to 980 teachers from 27…

  8. All Are Equal, but Some Are More Equal than Others: Managerialism and Gender Equality in Higher Education in Comparative Perspective

    Science.gov (United States)

    Teelken, Christine; Deem, Rosemary

    2013-01-01

    The main purpose of this paper is to investigate what impact new regimes of management and governance, including new managerialism, have had on perceptions of gender equality at universities in three Western European countries. While in accordance with national laws and EU directives, contemporary current management approaches in universities…

  9. What's in it for me? : A managerial perspective on the influence of the psychological contract on attitude towards change

    NARCIS (Netherlands)

    van den Heuvel, S.R.H.; Schalk, R.; Freese, C.; Timmerman, V.

    2016-01-01

    Purpose The purpose of this paper is to develop a model on how business managers perceive that an employee’s psychological contract influences his or her attitude toward an organizational change. More specifically, it aims to provide insight into the managerial views on: first, the affective,

  10. What ' s in it for me? A managerial perspective on the influence of the psychological contract on attitude towards change

    NARCIS (Netherlands)

    Sjoerd van den Heuvel; René Schalk; Charissa Freese; Volken Timmerman

    2016-01-01

    Purpose – The purpose of this paper is to develop a model on how business managers perceive that an employee’s psychological contract influences his or her attitude toward an organizational change. More specifically, it aims to provide insight into the managerial views on: first, the affective,

  11. The Managerial Turn in Higher Education? On the Interplay of Organizational and Occupational Change in German Academia

    Science.gov (United States)

    Krücken, Georg; Blümel, Albrecht; Kloke, Katharina

    2013-01-01

    The managerial turn in academia is currently broadly discussed. Based on empirical data gathered from a sample that includes all German universities, we can give a broad and fine-grained account of this turn. What we can clearly see is that whole new categories of administrative management positions have been created over the last years.…

  12. Compliance or Pragmatism: How Do Academics Deal with Managerialism in Higher Education? A Comparative Study in Three Countries

    Science.gov (United States)

    Teelken, Christine

    2012-01-01

    Universities throughout Europe have adopted organisational strategies, structures, technologies, management instruments and values that are commonly found in the private sector. While these alleged managerial measures may be considered useful, and have a positive effect on the quality of teaching and research, there is also evidence of detrimental…

  13. Analysis of Principals' Managerial Competencies for Effective Management of School Resources in Secondary Schools in Anambra State, Nigeria

    Science.gov (United States)

    Victor, Akinfolarin Akinwale

    2017-01-01

    This study analyses principals' managerial competencies for effective management of school resources in secondary schools in Anambra State. The study was conducted in Anambra State. The study population comprised 257 principals in public secondary schools in the State. The study adopted a descriptive survey design. A 24 items researcher developed…

  14. Study of Modern Approach to Build the Functional Models of Managerial and Engineering Systems in Training Specialists for Space Industry

    Directory of Open Access Journals (Sweden)

    N. V. Arhipova

    2016-01-01

    Full Text Available The SM8 Chair at Bauman Moscow State Technological University (BMSTU trains specialists majoring not only in design and manufacture, but also in operation and maintenance of space ground-based infrastructure.The learning courses in design, production, and operation of components of the missile and space technology, give much prominence to modeling. The same attention should be given to the modeling of managerial and engineering systems, with which deal both an expert and a leadman. It is important to choose the modeling tools for managerial and engineering systems with which they are to work and to learn how to apply these tools.The study of modern approach to functional modeling of managerial and engineering systems is held in the format of business game in laboratory class. A structural analysis and design technique (IDEFØ is considered as the means of modeling.The article stresses the IDEFØ approach advantages, namely: comprehensible graphical language, applicability to all-types and all-levels-of-hierarchy managerial and engineering systems modeling, popularity, version control means, teamwork tools. Moreover, the IDEFØ allows us to illustrate such notions, as point of view, system bounders, structure, control, feedback as applied to the managerial and engineering systems.The article offers a modified procedure to create an IDEFØ model in the context of training session. It also suggests a step-by-step procedure of the instruction session to be held, as well as of student self-training to have study credits, and a procedure of the work defense (final test.The approach under consideration can be applied to other training courses. The article proves it giving information about positive experience of its application.

  15. Managerial attitude to the implementation of quality management systems in Lithuanian support treatment and nursing hospitals

    Directory of Open Access Journals (Sweden)

    Lydeka Zigmas

    2006-09-01

    Full Text Available Abstract Background The regulations of the Quality Management System (QMS implementation in health care organizations were approved by the Lithuanian Ministry of Health in 1998. Following the above regulations, general managers of health care organizations had to initiate the QMS implementation in hospitals. As no research on the QMS implementation has been carried out in Lithuanian support treatment and nursing hospitals since, the objective of this study is to assess its current stage from a managerial perspective. Methods A questionnaire survey of general managers of Lithuanian support treatment and nursing hospitals was carried out in the period of January through March 2005. Majority of the items included in the questionnaire were measured on a seven-point Likert scale. During the survey, a total of 72 questionnaires was distributed, out of which 58 filled-in ones were returned (response rate 80.6 per cent; standard sampling error 0.029 at 95 per cent level of confidence. Results Quality Management Systems were found operating in 39.7 per cent of support treatment and nursing hospitals and currently under implementation in 46.6 per cent of hospitals (13.7% still do not have it. The mean of the respondents' perceived QMS significance is 5.8 (on a seven-point scale. The most critical issues related to the QMS implementation include procedure development (5.5, lack of financial resources (5.4 and information (5.1, and development of work guidelines (4.6, while improved responsibility and power sharing (5.2, better service quality (5.1 and higher patient satisfaction (5.1 were perceived by the respondents as the key QMS benefits. The level of satisfaction with the QMS among the management of the surveyed hospitals is mediocre (3.6. However it was found to be higher among respondents who were more competent in quality management, were familiar with ISO 9000 standards, and had higher numbers of employees trained in quality management. Conclusion

  16. A Study of Transformational Leadership and Managerial Competencies in the Flower Agricultural Sector of Colombia

    Directory of Open Access Journals (Sweden)

    Iliana Páez

    2014-07-01

    Full Text Available Rev.esc.adm.neg A good leadership is essential for the successful development of organizations and their staff members. Transformational leadership is a contemporary focus which highlights the moral bases of leadership and which has been valued in different cultures, being associated with its efectiviness and workers´ outcomes such as satisfaction and performance. This leadership is manifested through four basic performance dimensions (idealized influence, inspiring motivation, intellectual stimulus and individual consideration and through the managerial competencies of an executive. In this case study, these dimensions and ten leadership competencies (integrity and confidence, orientation to outcomes, importance of action, perseverance, effective use of time, effective communication, high performance team formation and development, decision making, business capacity and strategic management capacity have been analyzed taking an executive sample of 16 companies from the flower agricultural sector with the Florverde seal. This seal shows care for products and compromise with companies regarding environmental affairs and social responsibility, issues which are closely related with transformational leadership. Two transformational leadership dimensions were found: idealized influence and inspiring motivation, and its most outstanding competence was confidence and integrity, key elements for the successful development of transformational leadership.

  17. Career salience and work outcomes: A comparison of managerial and clerical employees

    Directory of Open Access Journals (Sweden)

    G. J. Lock

    1997-06-01

    Full Text Available The present research aimed to assess the relationships between career salience and job satisfaction, organisational commitment, and psychological well-being. In addition, the variations within these relationships between management and clerical employees were explored. Self report data was collected from 86 accounting employees at the headoffice of a large retail company in Johannesburg. Pearson product-moment correlations, t-tests and z-transformations were computed. The results indicated that there is a significant positive relationship between career salience and both job satisfaction and organisational commitment. These results were found to differ according to hierarchical level. The variable psychological well-being only yielded significant associations with career salience for the managerial group. Opsomming Die navorsing neem die verband tussen loopbaanmarkantheid en werksbevrediging, toewyding aan die organisasie, en psigologiese welstand in oënskou. Verskille in hierdie verhoudings tussen bestuur en klerklike personeel word vervolgens ondersoek. Selfrapporteringsdata is ingesamel van 86 boekhouers by die hoofkantoor van 'n vooraanstaande kleinhandelaar in Johannesburg. Pearson produk-moment korrelasies, t-toetse en z-transformasies is bereken. Die resultate het aangedui dat daar 'n beduidende positiewe verband is tussen loopbaanmarkantheid, aan die een kant, en sowel werksbevrediging as toewyding aan die organisasie aan die ander kant. Daar is verder gevind dat resultaat bemvloed word deur die hierargiese vlak waarop mense werk. Psigologiese welstand het byvoorbeeld net in die geval van bestuurders 'n beduidende korrelasie met loopbaanmarkantheid getoon.

  18. The impact of selected organizational variables and managerial leadership on radiation therapists' organizational commitment

    International Nuclear Information System (INIS)

    Akroyd, Duane; Legg, Jeff; Jackowski, Melissa B.; Adams, Robert D.

    2009-01-01

    The purpose of this study was to examine the impact of selected organizational factors and the leadership behavior of supervisors on radiation therapists' commitment to their organizations. The population for this study consists of all full time clinical radiation therapists registered by the American Registry of Radiologic Technologists (ARRT) in the United States. A random sample of 800 radiation therapists was obtained from the ARRT for this study. Questionnaires were mailed to all participants and measured organizational variables; managerial leadership variable and three components of organizational commitment (affective, continuance and normative). It was determined that organizational support, and leadership behavior of supervisors each had a significant and positive affect on normative and affective commitment of radiation therapists and each of the models predicted over 40% of the variance in radiation therapists organizational commitment. This study examined radiation therapists' commitment to their organizations and found that affective (emotional attachment to the organization) and normative (feelings of obligation to the organization) commitments were more important than continuance commitment (awareness of the costs of leaving the organization). This study can help radiation oncology administrators and physicians to understand the values their radiation therapy employees hold that are predictive of their commitment to the organization. A crucial result of the study is the importance of the perceived support of the organization and the leadership skills of managers/supervisors on radiation therapists' commitment to the organization.

  19. Participation of the Neighborhood Representatives (Mukhtars into Managerial Activities in Local Level: Burdur Case

    Directory of Open Access Journals (Sweden)

    Mustafa LAMBA

    2017-05-01

    Full Text Available Neighborhood representatives (mukhtars are the nearest administrative units to citizens in local level. It is required to take advantage of that the neighborhood representatives know their districts and residents better than central and local government authorities. In addition, it will be appropriate to the principles of subsidiarity and the European Charter of Local Self Government to determine problems and demands of neighborhoods by their representatives. It is necessary to maintain communication channels and keep close relations with neighborhood representatives by local governments to use that advantage efficiently. It is aimed in this study to determine the participation level of neighborhood representatives into managerial activities in local level. For that purpose, the neighborhood representatives in the center of Burdur province are included in the research. According to the findings, it has been determined that the neighborhood representatives have participated into various activities without experiencing any difficulty, and they have been informed about the services regarding to their neighborhoods, and they have kept close relationship with central and local administrations, and most of them could communicate with local authorities directly. Therefore, it has been concluded that the neighborhood representatives have been influential enough in decision-making mechanisms in local level in Burdur.

  20. The impact of selected organizational variables and managerial leadership on radiation therapists' organizational commitment

    Energy Technology Data Exchange (ETDEWEB)

    Akroyd, Duane [Department of Adult and Community College Education, College of Education, Campus Box 7801, North Carolina State University, Raleigh, NC 27695 (United States)], E-mail: duane_akroyd@ncsu.edu; Legg, Jeff [Department of Radiologic Sciences, Virginia Commonwealth University, Richmond, VA 23284 (United States); Jackowski, Melissa B. [Division of Radiologic Sciences, University of North Carolina School of Medicine 27599 (United States); Adams, Robert D. [Department of Radiation Oncology, University of North Carolina School of Medicine 27599 (United States)

    2009-05-15

    The purpose of this study was to examine the impact of selected organizational factors and the leadership behavior of supervisors on radiation therapists' commitment to their organizations. The population for this study consists of all full time clinical radiation therapists registered by the American Registry of Radiologic Technologists (ARRT) in the United States. A random sample of 800 radiation therapists was obtained from the ARRT for this study. Questionnaires were mailed to all participants and measured organizational variables; managerial leadership variable and three components of organizational commitment (affective, continuance and normative). It was determined that organizational support, and leadership behavior of supervisors each had a significant and positive affect on normative and affective commitment of radiation therapists and each of the models predicted over 40% of the variance in radiation therapists organizational commitment. This study examined radiation therapists' commitment to their organizations and found that affective (emotional attachment to the organization) and normative (feelings of obligation to the organization) commitments were more important than continuance commitment (awareness of the costs of leaving the organization). This study can help radiation oncology administrators and physicians to understand the values their radiation therapy employees hold that are predictive of their commitment to the organization. A crucial result of the study is the importance of the perceived support of the organization and the leadership skills of managers/supervisors on radiation therapists' commitment to the organization.