Arabidopsis CDS blastp result: AK065420 [KOME

Lifescience Database Archive (English)

Full Text Available AK065420 J013022D10 At5g13630.1 magnesium-chelatase subunit chlH, chloroplast, puta...tive / Mg-protoporphyrin IX chelatase, putative (CHLH) nearly identical to magnesium chelatase subunit GI:11...54627 from [Arabidopsis thaliana]; contains Pfam profile: PF02514 CobN/magnesium chelatase family protein 1e-166 ...

Gun control saves lives

African Journals Online (AJOL)

gun control legislation. One study estimated that more than 4 500 lives were saved across five SA cities from 2001 to 2005.[5] Pro-gun interest groups seeking to promote gun ownership and diffusion have attacked these findings, suggesting that stricter gun control was only enacted in 2004 following the publication of ...

Effects of Exposure to Gun Violence in Movies on Children's Interest in Real Guns.

Science.gov (United States)

Dillon, Kelly P; Bushman, Brad J

2017-11-01

More US children die by accidental gun use than children in other developed countries. One factor that can influence children's interest in guns is exposure to media containing guns. To test whether children who see a movie containing guns will handle a real gun longer and will pull the trigger more times than children who see the same movie not containing guns. One hundred four children aged 8 to 12 years recruited through advertisements were randomly assigned in pairs to watch a 20-minute PG-rated movie containing or not containing guns in a university laboratory. Children then played with toys and games in a room for 20 minutes while being video recorded. A cabinet in the room contained a real (disabled) gun with a sensor counting trigger pulls. Recordings were coded for the time spent holding the gun and in aggressive play. Data were collected from July 15, 2015, through January 1, 2016, and analyzed using generalized estimating equations (Tweedie log-link for time spent holding the gun; Poisson log-link for pulling the trigger). The 2 main outcomes were time spent holding the gun and the number of trigger pulls. Control variables included sex, age, trait aggressiveness, exposure to violent media, interest in guns, and number of guns at home. Among the 104 study participants (62 boys [59.6%] and 42 girls [40.4%]; mean (SD) age, 9.9 [1.5] years), the adjusted median number of trigger pulls among children who saw the movie containing guns was 2.8 (interquartile range [IQR], 0.2-2.8) compared with 0.01 (IQR, 0.01-0.2) among children who saw the movie not containing guns (adjusted odds ratio, 22.3; 95% CI, 6.0-83.4; P gun among children who saw a movie containing guns was 53.1 (IQR, 35.5-53.1) compared with 11.1 (IQR, 10.7-16.7) among children who saw the movie not containing guns (adjusted odds ratio, 3.0; 95% CI, 0.9-9.9; P = .07). Qualitative analyses on 4 pairs from each condition found that children who saw the movie containing guns also played more

Gun ownership and social gun culture.

Science.gov (United States)

Kalesan, Bindu; Villarreal, Marcos D; Keyes, Katherine M; Galea, Sandro

2016-06-01

We assessed gun ownership rates in 2013 across the USA and the association between exposure to a social gun culture and gun ownership. We used data from a nationally representative sample of 4000 US adults, from 50 states and District of Columbia, aged >18 years to assess gun ownership and social gun culture performed in October 2013. State-level firearm policy information was obtained from the Brady Law Center and Injury Prevention and Control Center. One-third of Americans reported owning a gun, ranging from 5.2% in Delaware to 61.7% in Alaska. Gun ownership was 2.25-times greater among those reporting social gun culture (PR=2.25, 95% CI 2.02 to 2.52) than those who did not. In conclusion, we found strong association between social gun culture and gun ownership. Gun cultures may need to be considered for public health strategies that aim to change gun ownership in the USA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Water gun vs air gun: A comparison

Science.gov (United States)

Hutchinson, D.R.; Detrick, R. S.

1984-01-01

The water gun is a relatively new marine seismic sound source that produces an acoustic signal by an implosive rather than explosive mechanism. A comparison of the source characteristics of two different-sized water guns with those of conventional air guns shows the the water gun signature is cleaner and much shorter than that of a comparable-sized air gun: about 60-100 milliseconds (ms) for an 80-in3. (1.31-liter (I)) water gun compared with several hundred ms for an 80-in3. (1.31-1) air gun. The source spectra of water guns are richer in high frequencies (>200 Hz) than are those of air guns, but they also have less energy than those of air guns at low frequencies. A comparison between water gun and air gun reflection profiles in both shallow (Long Island Sound)-and deep (western Bermuda Rise)-water settings suggests that the water gun offers a good compromise between very high resolution, limited penetration systems (e.g. 3.5-kHz profilers and sparkers) and the large volume air guns and tuned air gun arrays generally used where significant penetration is required. ?? 1984 D. Reidel Publishing Company.

Hard-driven rail-gun tests

International Nuclear Information System (INIS)

Peterson, D.R.; Adams, D.F.; Cummings, C.E.; Fowler, C.M.; Kerrisk, J.F.; Marsh, S.P.; Parker, J.V.

1983-01-01

A number of prototype rail-gun designs have been tested, powered by explosive magnetic flux compression generators. Peak currents as high as 1.3 MA were delivered. Rail guns with 50-mm-thick Kevlar fiberwound structural shells were able to survive these high currents with minimum mechanical damage and were refired after enlarging the bores 0.2 to 0.4 mm to remove arc damage. In some tests, mechanical damage occurred that was apparently caused by the rebound of the gun after firing. Although the Kevlar shells had more than adequate strength, they appeared to lack sufficient stiffness, allowing excessive deflections. The use of a steel structural shell with a Kevlar sleeve was an improvement. Intrusion into the seams of the rail guns and condensation of material from the plasma armature were observed. Improved sealing of seams is indicated. In some cases, we suspect maldistribution of current within the gun; that is, not all the current delivered to the breech of the gun seemed to reach the plasma armature. Experiments are being designed to quantify the effects discussed. Rail guns of advanced design are being fabricated. An 18-g titanium projectile was accelerated to 2.4 km/s in a 16-mm-round-bore, 0.6-m-long gun, 4-6 g polycarbonate projectiles were accelerated to 3.5 km/s in 13-mm-square-bore, 1.2-m-long rail guns. All tests were conducted at atmospheric pressure

Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

DEFF Research Database (Denmark)

Leurs, Ulrike; Lohse, Brian; Rand, Kasper Dyrberg

2014-01-01

Inhibition of histone demethylases has within recent years advanced into a new strategy for treating cancer and other diseases. Targeting specific histone demethylases can be challenging as the active sites of KDM1A-B and KDM-4A-D histone demethylases, respectively, are highly conserved. Most...... inhibitors developed up-to-date target either the cofactor- or substrate-binding sites of these enzymes, resulting in a lack of selectivity and off-target effects. This study describes the discovery of the first peptide-based inhibitors of KDM4 histone demethylases that do not share the histone peptide...... sequence, or inhibit through substrate competition. Through screening of DNA-encoded peptide libraries against KDM1 and -4 histone demethylases by phage display, two cyclic peptides targeting the histone demethylase KDM4C were identified and developed as inhibitors by amino acid replacement, truncation...

Gun Control, Gun Ownership, and Suicide Prevention.

Science.gov (United States)

Lester, David

1988-01-01

Explored relationship between the extent of gun ownership and the strictness of gun control laws to suicide and homicide rates in the nine major geographic regions of the United States. Found gun ownership, rather than the strictness of gun control laws, was the strongest correlate of the rates of suicide and homicide by guns. (Author)

Lake Wobegon’s Guns: Overestimating Our Gun-Related Competences

Directory of Open Access Journals (Sweden)

Emily Stark

2016-02-01

Full Text Available The Lake Wobegon Effect is a general tendency for people to overestimate their own abilities. In this study, the authors conducted a large, nationally-representative survey of U.S. citizens to test whether Americans overestimate their own gun-relevant personality traits, gun safety knowledge, and ability to use a gun in an emergency. The authors also tested how gun control attitudes, political identification, gender, and gun experience affect self-perceptions. Consistent with prior research on the Lake Wobegon Effect, participants overestimated their gun-related competencies. Conservatives, males, and pro-gun advocates self-enhanced somewhat more than their counterparts but this effect was primarily due to increased gun experience among these participants. These findings are important to policymakers in the area of gun use, because overconfidence in one’s gun-related abilities may lead to a reduced perceived need for gun training.

RF Processing Experience with the GTF Prototype RF Gun

International Nuclear Information System (INIS)

Schmerge, J.F.

2010-01-01

The SSRL Gun Test Facility (GTF) was built to develop a high brightness electron injector for the LCLS and has been operational since 1996. A total of five different metal cathodes (4 Cu and 1 Mg) have been installed on the GTF gun. The rf processing history with the different cathodes will be presented including peak field achieved at the cathode. The LCLS gun is intended to operate at 120 MV/m and fields up to 140 MV/m have been achieved in the GTF gun. After installing a new cathode the number of rf pulses required to reach 120 MV/m is approximately 5-10 million. Total emitted dark current and Fowler Nordheim plots are also shown over the life of the cathode. The GTF photo-injector gun is an S-band standing-wave structure, with two resonant cavities and an intervening thick washer (Figure 1). The flat, back wall of the first cavity is a copper plate that serves as photocathode when illuminated with ultraviolet light from a pulsed, high-power laser. RF power enters the gun through an iris on the outer wall of the second cavity, and is coupled to the first through the axial opening of the washer. The first cavity is often referred to as a half cell, because its full-cell length has been truncated by the cathode plate and the second cavity is called the full cell. The gun is designed to operate in a π mode, with the peak field on axis in each cell approximately equal. The maximum in the half cell occurs at the cathode, and in the full cell near the center of the cavity. The field profile and tuning procedures are discussed in a separate tech note (1).

The effects of Urtica dioica L. leaf extract on aniline 4-hydroxylase in mice.

Science.gov (United States)

Ozen, Tevfik; Korkmaz, Halil

2009-01-01

The effects of hydroalcoholic (80% ethanol-20% water) extract of Urtica dioica L. on microsomal aniline 4-hydroxylase (A4H) were investigated in the liver of Swiss albino mice (8- 10-weeks-old) treated with two doses (50 and 100 mg/kg body weight, given orally for 14 days ). The activities of A4H showed a significant increase in the liver at both dose levels of extract treatment. The hydroalcoholic extract of Urtica dioica induced the activities of A4H that had been increased by treatment of metal ions (Mg2+ and Ca2+) and the mixture of cofactors (NADH and NADPH). At saturated concentration of cofactor, microsomal A4H exhibited significantly even higher activities in the presence of the mixture of cofactors than NADPH and NADH. Mg2+ and Ca2+ ions acted as stimulants in vitro. The present results suggest that the hydroalcoholic extract of Urtica dioica may have modalatory effect on aniline hydroxylase at least in part and enhance the activity of A4H adding metals ions and cofactors.

Engineering redox balance through cofactor systems.

Science.gov (United States)

Chen, Xiulai; Li, Shubo; Liu, Liming

2014-06-01

Redox balance plays an important role in the production of enzymes, pharmaceuticals, and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximal carbon flux towards target metabolites with no fluctuations in redox. This requires functional cofactor systems that support dynamic homeostasis between different redox states or functional stability in a given redox state. Redox balance can be achieved by improving the self-balance of a cofactor system, regulating the substrate balance of a cofactor system, and engineering the synthetic balance of a cofactor system. This review summarizes how cofactor systems can be manipulated to improve redox balance in microbes. Copyright © 2014 Elsevier Ltd. All rights reserved.

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.

Science.gov (United States)

Malm, Sven; Jusko, Monika; Eick, Sigrun; Potempa, Jan; Riesbeck, Kristian; Blom, Anna M

2012-01-01

Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b-binding protein (C4BP) and Factor H (FH). Yet, the significance of complement inhibitor acquisition in P. intermedia infection and FI binding by Gram-negative pathogens has not been addressed. Here we show that P. intermedia isolates bound purified FI as well as FI directly from heat-inactivated human serum. FI bound to bacteria retained its serine protease activity as shown in degradation experiments with (125)I-labeled C4b. Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. We propose that FI binding by P. intermedia represents a new mechanism contributing to complement evasion by a Gram-negative bacterial pathogen associated with chronic diseases.

Gun Play

Science.gov (United States)

Mechling, Jay

2008-01-01

Biology and the particular gun culture of the United States come together to explain the persistent and powerful attraction of American boys to both real guns and toy guns. The 1990s saw adults begin to conflate "the gun problem" with "the boy problem," sparking attempts (largely failed) to banish toy guns from homes and…

Unusual Case of Suicide With a Modified Trap Gun.

Science.gov (United States)

Vadysinghe, Amal; Dassanayake, Prasanna; Wickramasinghe, Medhani

2017-06-01

Trap gun is an illegal, locally manufactured gun with a basic trip system used to hunt wild animals. The body of a 28-year-old man was found in the jungle in supine position with both legs apart. A trap gun was between the legs pointing toward the cranial side of the body. It had 2 free wires that were not connected together. There was no evidence of foul play.The body had a single-entry wound (2.5-cm diameter) in the anterior chest, with blackening, burning, and tattooing. Six metal particles and nylon clothing material were embedded into soft tissue. No exit wound was found. Toxicology analysis reported an alcohol level of 72 mg/dL. The cause of death was multiple shrapnel injury to the chest at close to intermediate range by a single discharge from a trap gun. Circumstance was concluded as suicide.Ballistic and firearm experts opined that an illegal, manually operated, battery-powered ignition device was used to ignite the gun powder. We report the first case of suicide by a modified trap gun in literature.

Purification, crystallization and preliminary crystallographic analysis of a multiple cofactor-dependent DNA ligase from Sulfophobococcus zilligii

International Nuclear Information System (INIS)

Supangat, Supangat; An, Young Jun; Sun, Younguk; Kwon, Suk-Tae; Cha, Sun-Shin

2010-01-01

A recombinant multiple cofactor-dependent DNA ligase from S. zilligii has been purified and crystallized. X-ray diffraction data were collected to 2.9 Å resolution and the crystals belonged to space group P1. A recombinant DNA ligase from Sulfophobococcus zilligii that shows multiple cofactor specificity (ATP, ADP and GTP) was expressed in Escherichia coli and purified under reducing conditions. Crystals were obtained by the microbatch crystallization method at 295 K in a drop containing 1 µl protein solution (10 mg ml −1 ) and an equal volume of mother liquor [0.1 M HEPES pH 7.5, 10%(w/v) polyethylene glycol 10 000]. A data set was collected to 2.9 Å resolution using synchrotron radiation. The crystals belonged to space group P1, with unit-cell parameters a = 63.7, b = 77.1, c = 77.8 Å, α = 83.4, β = 82.4, γ = 74.6°. Assuming the presence of two molecules in the unit cell, the solvent content was estimated to be about 53.4%

Replacing Electron Transport Cofactors with Hydrogenases

KAUST Repository

Laamarti, Rkia

2016-12-01

Enzymes have found applications in a broad range of industrial production processes. While high catalytic activity, selectivity and mild reaction conditions are attractive advantages of the biocatalysts, particularly costs arising from required cofactors pose a sever limitation. While cofactor-recycling systems are available, their use implies constraints for process set-up and conditions, which are a particular problem e.g. for solid-gas-phase reactions. Several oxidoreductases are able to directly exchange electrons with electrodes. Hence, the co-immobilization of both, an electron-utilizing and an electron-generating oxidoreductase on conductive nanoparticles should facilitate the direct electron flow from an enzymatic oxidation to a reduction reaction circumventing redox-cofactors requirements. In such a set-up, hydrogenases could generate and provide electrons directly form gaseous hydrogen. This thesis describes the co-immobilization of the oxygen tolerant hydrogenases from C. eutropha or C. metallidurans and cytochrome P450BM3 as test system. Conductive material in the form of carbon nanotubes (CNT) serves as a suitable support. A combination of the hydrogenase and the catalytic domain of P450BM3 immobilized on carbon nanotubes were tested for the oxidation of lauric acid in the presence of hydrogen instead of an electron-transport cofactor. The GC-MS analysis reveals the conversion of 4% of lauric acid (LA) into three products, which correspond to the hydroxylated lauric acid in three different positions with a total turnover (TON) of 34. The product distribution is similar to that obtained when using the wildtype P450BM3 with the nicotinamide adenine dinucleotide phosphate (NADPH) cofactor. Such electronic coupling couldn’t be achieved for the conversion of other substrates such as propane and cyclohexane, probably due to the high uncoupling rate within the heme-domain of cytochrome P450BM3 when unnatural substrates are introduced.

Gun Shows and Gun Violence: Fatally Flawed Study Yields Misleading Results

Science.gov (United States)

Hemenway, David; Webster, Daniel; Pierce, Glenn; Braga, Anthony A.

2010-01-01

A widely publicized but unpublished study of the relationship between gun shows and gun violence is being cited in debates about the regulation of gun shows and gun commerce. We believe the study is fatally flawed. A working paper entitled “The Effect of Gun Shows on Gun-Related Deaths: Evidence from California and Texas” outlined this study, which found no association between gun shows and gun-related deaths. We believe the study reflects a limited understanding of gun shows and gun markets and is not statistically powered to detect even an implausibly large effect of gun shows on gun violence. In addition, the research contains serious ascertainment and classification errors, produces results that are sensitive to minor specification changes in key variables and in some cases have no face validity, and is contradicted by 1 of its own authors’ prior research. The study should not be used as evidence in formulating gun policy. PMID:20724672

Encyclopedia of Gun Control and Gun Rights.

Science.gov (United States)

Utter, Glenn H.

This reference volume provides information on gun control and gun rights, including resources on the debate surrounding the Second Amendment and individuals and organizations focused on gun issues, along with statutes, court cases, events, and publications surrounding this current topic. Highlighted are the important organizations and their…

Protonation/reduction dynamics at the [4Fe-4S] cluster of the hydrogen-forming cofactor in [FeFe]-hydrogenases.

Science.gov (United States)

Senger, Moritz; Mebs, Stefan; Duan, Jifu; Shulenina, Olga; Laun, Konstantin; Kertess, Leonie; Wittkamp, Florian; Apfel, Ulf-Peter; Happe, Thomas; Winkler, Martin; Haumann, Michael; Stripp, Sven T

2018-01-31

The [FeFe]-hydrogenases of bacteria and algae are the most efficient hydrogen conversion catalysts in nature. Their active-site cofactor (H-cluster) comprises a [4Fe-4S] cluster linked to a unique diiron site that binds three carbon monoxide (CO) and two cyanide (CN - ) ligands. Understanding microbial hydrogen conversion requires elucidation of the interplay of proton and electron transfer events at the H-cluster. We performed real-time spectroscopy on [FeFe]-hydrogenase protein films under controlled variation of atmospheric gas composition, sample pH, and reductant concentration. Attenuated total reflection Fourier-transform infrared spectroscopy was used to monitor shifts of the CO/CN - vibrational bands in response to redox and protonation changes. Three different [FeFe]-hydrogenases and several protein and cofactor variants were compared, including element and isotopic exchange studies. A protonated equivalent (HoxH) of the oxidized state (Hox) was found, which preferentially accumulated at acidic pH and under reducing conditions. We show that the one-electron reduced state Hred' represents an intrinsically protonated species. Interestingly, the formation of HoxH and Hred' was independent of the established proton pathway to the diiron site. Quantum chemical calculations of the respective CO/CN - infrared band patterns favored a cysteine ligand of the [4Fe-4S] cluster as the protonation site in HoxH and Hred'. We propose that proton-coupled electron transfer facilitates reduction of the [4Fe-4S] cluster and prevents premature formation of a hydride at the catalytic diiron site. Our findings imply that protonation events both at the [4Fe-4S] cluster and at the diiron site of the H-cluster are important in the hydrogen conversion reaction of [FeFe]-hydrogenases.

State Gun Law Environment and Youth Gun Carrying in the United States.

Science.gov (United States)

Xuan, Ziming; Hemenway, David

2015-11-01

Gun violence and injuries pose a substantial threat to children and youth in the United States. Existing evidence points to the need for interventions and policies for keeping guns out of the hands of children and youth. (1) To examine the association between state gun law environment and youth gun carrying in the United States, and (2) to determine whether adult gun ownership mediates this association. This was a repeated cross-sectional observational study design with 3 years of data on youth gun carrying from US states. The Youth Risk Behavior Survey comprises data of representative samples of students in grades 9 to 12 from biennial years of 2007, 2009, and 2011. We hypothesized that states with more restrictive gun laws have lower rates of youth gun carrying, and this association is mediated by adult gun ownership. State gun law environment as measured by state gun law score. Youth gun carrying was defined as having carried a gun on at least 1 day during the 30 days before the survey. In the fully adjusted model, a 10-point increase in the state gun law score, which represented a more restrictive gun law environment, was associated with a 9% decrease in the odds of youth gun carrying (adjusted odds ratio [AOR], 0.91 [95% CI, 0.86-0.96]). Adult gun ownership mediated the association between state gun law score and youth gun carrying (AOR, 0.94 [ 95% CI, 0.86-1.01], with 29% attenuation of the regression coefficient from -0.09 to -0.07 based on bootstrap resampling). More restrictive overall gun control policies are associated with a reduced likelihood of youth gun carrying. These findings are relevant to gun policy debates about the critical importance of strengthening overall gun law environment to prevent youth gun carrying.

Large Bore Powder Gun Qualification (U)

Energy Technology Data Exchange (ETDEWEB)

Rabern, Donald A. [Los Alamos National Laboratory; Valdiviez, Robert [Los Alamos National Laboratory

2012-04-02

A Large Bore Powder Gun (LBPG) is being designed to enable experimentalists to characterize material behavior outside the capabilities of the NNSS JASPER and LANL TA-55 PF-4 guns. The combination of these three guns will create a capability to conduct impact experiments over a wide range of pressures and shock profiles. The Large Bore Powder Gun will be fielded at the Nevada National Security Site (NNSS) U1a Complex. The Complex is nearly 1000 ft below ground with dedicated drifts for testing, instrumentation, and post-shot entombment. To ensure the reliability, safety, and performance of the LBPG, a qualification plan has been established and documented here. Requirements for the LBPG have been established and documented in WE-14-TR-0065 U A, Large Bore Powder Gun Customer Requirements. The document includes the requirements for the physics experiments, the gun and confinement systems, and operations at NNSS. A detailed description of the requirements is established in that document and is referred to and quoted throughout this document. Two Gun and Confinement Systems will be fielded. The Prototype Gun will be used primarily to characterize the gun and confinement performance and be the primary platform for qualification actions. This gun will also be used to investigate and qualify target and diagnostic modifications through the life of the program (U1a.104 Drift). An identical gun, the Physics Gun, will be fielded for confirmatory and Pu experiments (U1a.102D Drift). Both guns will be qualified for operation. The Gun and Confinement System design will be qualified through analysis, inspection, and testing using the Prototype Gun for the majority of process. The Physics Gun will be qualified through inspection and a limited number of qualification tests to ensure performance and behavior equivalent to the Prototype gun. Figure 1.1 shows the partial configuration of U1a and the locations of the Prototype and Physics Gun/Confinement Systems.

Cofactor engineering for advancing chemical biotechnology.

Science.gov (United States)

Wang, Yipeng; San, Ka-Yiu; Bennett, George N

2013-12-01

Cofactors provide redox carriers for biosynthetic reactions, catabolic reactions and act as important agents in transfer of energy for the cell. Recent advances in manipulating cofactors include culture conditions or additive alterations, genetic modification of host pathways for increased availability of desired cofactor, changes in enzyme cofactor specificity, and introduction of novel redox partners to form effective circuits for biochemical processes and biocatalysts. Genetic strategies to employ ferredoxin, NADH and NADPH most effectively in natural or novel pathways have improved yield and efficiency of large-scale processes for fuels and chemicals and have been demonstrated with a variety of microbial organisms. Copyright © 2013 Elsevier Ltd. All rights reserved.

A metastable Mg11Sm phase obtained by rapid solidification

International Nuclear Information System (INIS)

Budurov, S.

1993-01-01

Molten Mg-Sm alloys with a Sm concentration of 4.93, 6.86, and 8.35 at.% were rapidly soldified with the aid of a shock wave gun device. Investigations of the obtained splats were performed with the aid of DSC, X-ray analysis, and metallography. Rapid soldification of the eutectic MgSm 8.35 alloy forms a new Im3m-type phase. (orig.)

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites

Science.gov (United States)

Mortusewicz, Oliver; Roth, Wera; Li, Na; Cardoso, M. Cristina; Meisterernst, Michael; Leonhardt, Heinrich

2008-01-01

The multifunctional nuclear protein positive cofactor 4 (PC4) is involved in various cellular processes including transcription, replication, and chromatin organization. Recently, PC4 has been identified as a suppressor of oxidative mutagenesis in Escherichia coli and Saccharomyces cerevisiae. To investigate a potential role of PC4 in mammalian DNA repair, we used a combination of live cell microscopy, microirradiation, and fluorescence recovery after photobleaching analysis. We found a clear accumulation of endogenous PC4 at DNA damage sites introduced by either chemical agents or laser microirradiation. Using fluorescent fusion proteins and specific mutants, we demonstrated that the rapid recruitment of PC4 to laser-induced DNA damage sites is independent of poly(ADP-ribosyl)ation and γH2AX but depends on its single strand binding capacity. Furthermore, PC4 showed a high turnover at DNA damages sites compared with the repair factors replication protein A and proliferating cell nuclear antigen. We propose that PC4 plays a role in the early response to DNA damage by recognizing single-stranded DNA and may thus initiate or facilitate the subsequent steps of DNA repair. PMID:19047459

Electromagnetic Guns versus Conventional Guns - a performance comparison

NARCIS (Netherlands)

Reus, N.M. de; Weijden, J. van der

1993-01-01

Performance improvement is one of the key issues of Electromagnetic gun systems compared to conventional gun systems. Due to higher muzzle velocities, the gun's fire control computer will be able to predict the target's future position more accurately because prediction time will be smaller. In this

Optimization Strategies for Hardware-Based Cofactorization

Science.gov (United States)

Loebenberger, Daniel; Putzka, Jens

We use the specific structure of the inputs to the cofactorization step in the general number field sieve (GNFS) in order to optimize the runtime for the cofactorization step on a hardware cluster. An optimal distribution of bitlength-specific ECM modules is proposed and compared to existing ones. With our optimizations we obtain a speedup between 17% and 33% of the cofactorization step of the GNFS when compared to the runtime of an unoptimized cluster.

Laser-pulsed relativistic electron gun

International Nuclear Information System (INIS)

Sherman, N.K.

1986-01-01

A relativistic (β ≅ 0.8) electron gun with good emittance and subnanosecond pulse duration which can be synchronized to picosecond laser pulses is being developed at NRC for use in studies of particle acceleration by lasers. Bursts of electron pulses exceeding 280 keV in energy have been extracted into air form a laser-driven vacuum photodiode. Trains of 5 ps pulses of ultraviolet UV light illuminate a magnesium cathode. Photoelectrons emitted from the cathode are accelerated in a graded electrostatic potential set up by a 360 kV Marx-generator. The UV pulses are obtained by doubling the frequency of a 606 nm dye laser modelocked at 160 MHz. Electron energies were measured by residual range in an echelon of Al foils. Total charge per burst was measured by picoammeter. Time structure of the bursts has been examined with plastic scintillator and a fast photomultiplier. Tests on a low voltage photodiode achieved a current density of 180 A/cm/sup 2/ from an Mg cathode, with quantum efficiency of 2.4 x 10/sup -6/ electron per UV photon. The brevity and intensity of the laser pulses cause the electric charge collected per pulse to increase linearly with bias voltage rather than according to the Langmuir-Child law. Gun emittance is about 150 mm-msr and beam brightness is about 1A/cm/sup 2/-sr. Estimated duration of individual electron pulses of a burst is about 400 ps with instantaneous current of about 0.1 mA. Energy spread within one pulse is expected to be about 15%. This gun has the potential to be a useful source of relativistic electrons for laser acceleration studies

Coaxial-gun design and testing for the PLX- α Project

Science.gov (United States)

Witherspoon, F. Douglas; Brockington, Samuel; Case, Andrew; Cruz, Edward; Luna, Marco; Langendorf, Samuel

2016-10-01

We describe the Alpha coaxial gun designed for a 60-gun scaling study of spherically imploding plasma liners as a standoff driver for plasma-jet-driven magneto-inertial fusion (PJMIF). The guns operate over a range of parameters: 0.5-5.0 mg of Ar, Ne, N2, Kr, and Xe; 20-60 km/s; 2 × 1016 cm-3 muzzle density; and up to 7.5 kJ stored energy per gun. Each coaxial gun incorporates a fast dense gas injection and triggering system, a compact low-weight pfn with integral sparkgap switching, and a contoured gap designed to suppress the blow-by instability. The latest design iteration incorporates a faster more robust gas valve, an improved electrode contour, a custom 600- μF, 5-kV pfn, and six inline sparkgap switches operated in parallel. The switch and pfn are mounted directly to the back of the gun and are designed to reduce inductance, cost, and complexity, maximize efficiency and system reliability, and ensure symmetric current flow. We provide a brief overview of the design choices, the projected performance over the parameter ranges mentioned above, and experimental results from testing of the PLX- α coaxial gun. This work supported by the ARPA-E ALPHA Program.

The Effects of Gun Ownership Rates and Gun Control Laws on Suicide Rates

OpenAIRE

Mark Gius

2011-01-01

The purpose of the present study is to determine the effects of gun control laws and gun ownership rates on state-level suicide rates. Using the most recent data on suicide rates, gun control measures, and gun ownership rates, the results of the present study suggest that states that require handgun permits have lower gun-related suicide rates, and states that have higher gun ownership rates have higher gun-related suicide rates. Regarding non-gun suicides, results suggest that stricter gun c...

Gun Safety

Science.gov (United States)

Many U.S. households have guns, but they can cause harm if not handled properly. Here are some things you can do to keep yourself and ... safe: Teach children that they shouldn't touch guns and that if they see a gun, to ...

Single crystal structures of the new vanadates CuMgVO{sub 4} and AgMgVO{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Ben Yahia, Hamdi, E-mail: Hyahia@qf.org.qa [Research Institute of Electrochemical Energy, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577 (Japan); Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 5825, Doha (Qatar); Shikano, Masahiro, E-mail: shikano.masahiro@aist.go.jp [Research Institute of Electrochemical Energy, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577 (Japan); Essehli, Rachid; Belharouak, Ilias [Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 5825, Doha (Qatar)

2016-08-01

The new compounds CuMgVO{sub 4} and AgMgVO{sub 4} have been synthesized by a solid state reaction route. Their crystal structures were determined from single-crystal X-ray diffraction data. CuMgVO{sub 4} crystallizes with Na{sub 2}CrO{sub 4}-type structure with space group Cmcm, a = 5.6932 (10), b = 8.7055 (15), c = 6.2789 (10) Å, V = 311.20 (9) Å{sup 3}, and Z = 4, whereas AgMgVO{sub 4} crystallizes in the maricite-type structure with space group Pnma, a = 9.4286 (14), b = 6.7465 (10), c = 5.3360 (8) Å, V = 339.42 (9) Å{sup 3}, and Z = 4. Both structures of CuMgVO{sub 4}, and AgMgVO{sub 4} contain MgO{sub 4} chains made up of edge-sharing MgO{sub 6} octahedra. In CuMgVO{sub 4} the MgO{sub 4} chains are interconnected through CuVO{sub 4} double chains made up of VO{sub 4} and CuO{sub 4} tetrahedra sharing corners and edges, however in AgMgVO{sub 4} the chains are interlinked by the VO{sub 4} and AgO{sub 4} tetrahedra sharing only corners. - Highlights: • We have been able to grow CuMgVO{sub 4} and AgMgVO{sub 4} single crystals. • We solved their crystal structures using single crystal data. • We compared the crystal structures of CuMgVO{sub 4} and AgMgVO{sub 4}.

Coaxial Plasma Gun Development for the ARPA-E PLX- α Project

Science.gov (United States)

Witherspoon, F. Douglas; Case, Andrew; Brockington, Samuel

2015-11-01

We describe the renewed effort to design and build coaxial plasma guns appropriate for a scaling study of spherically imploding plasma liners as a standoff magneto-inertial-fusion driver under the ARPA-E Accelerating Low-Cost Plasma Heating And Assembly (ALPHA) program. HyperV joins LANL, UAH, UNM, BNL, and Tech-X to develop, build, operate and analyze a 60 plasma gun experiment using the existing PLX facility at LANL. The guns will be designed to operate over a scaling range of operating parameters: 0.5-5.0 mg of Ar, Ne, N2, Kr, and Xe; 20-60 km/s; 1016 -1017 cm-3 muzzle density; and up to 7.5 kJ stored energy per gun. Each gun is planned to incorporate contoured gaps, fast dense gas injection and triggering, and innovative integral sparkgap switching and pfn configurations to reduce inductance, cost, and complexity, and to increase efficiency and system reliability. We will describe the overall design approach for the guns and pulsed power systems. This work supported by the ARPA-E ALPHA Program.

Magnetized gun experiments

International Nuclear Information System (INIS)

Jarboe, T.R.; Henins, I.; Hoida, H.W.; Marshall, J.; Sherwood, A.R.

1981-01-01

In the Los Alamos Magnetized Gun Experiment we are attempting to produce a compact torus in a manner similar to an earlier experiment of Alfven. In our experiment a solenoidal coil is placed inside the inner electrode of a coaxial plasma gun. This coil produces an axial magnetic field inside the inner electrode which diverges and becomes a largely radial field in front of the gun muzzle. The idea is that when the gun is fired, the plasma escaping from the gun stretches these radial fields along the axial direction away from the gun, and these field lines can reconnect behind the plasma forming the poloidal field of the compact torus. The magnetic field generated by the gun current becomes the toroidal field and the major axis of the compact torus will be the same as the axis of the coaxial gun. Recent interest in this possible method of compact torus generation was stimulated by C. Hartman, and the approach is also being pursued in the field-reversed plasma gun experiment at LLL

Insights into hydrocarbon formation by nitrogenase cofactor homologs.

Science.gov (United States)

Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W

2015-04-14

The L-cluster is an all-iron homolog of nitrogenase cofactors. Driven by europium(II) diethylenetriaminepentaacetate [Eu(II)-DTPA], the isolated L-cluster is capable of ATP-independent reduction of CO and CN(-) to C1 to C4 and C1 to C6 hydrocarbons, respectively. Compared to its cofactor homologs, the L-cluster generates considerably more CH4 from the reduction of CO and CN(-), which could be explained by the presence of a "free" Fe atom that is "unmasked" by homocitrate as an additional site for methanation. Moreover, the elevated CH4 formation is accompanied by a decrease in the amount of longer hydrocarbons and/or the lengths of the hydrocarbon products, illustrating a competition between CH4 formation/release and C-C coupling/chain extension. These observations suggest the possibility of designing simpler synthetic clusters for hydrocarbon formation while establishing the L-cluster as a platform for mechanistic investigations of CO and CN(-) reduction without complications originating from the heterometal and homocitrate components. Nitrogenase is a metalloenzyme that is highly complex in structure and uniquely versatile in function. It catalyzes two reactions that parallel two important industrial processes: the reduction of nitrogen to ammonia, which parallels the Haber-Bosch process in ammonia production, and the reduction of carbon monoxide to hydrocarbons, which parallels the Fischer-Tropsch process in fuel production. Thus, the significance of nitrogenase can be appreciated from the perspective of the useful products it generates: (i) ammonia, the "fixed" nitrogen that is essential for the existence of the entire human population; and (ii) hydrocarbons, the "recycled" carbon fuel that could be used to directly address the worldwide energy shortage. This article provides initial insights into the catalytic characteristics of various nitrogenase cofactors in hydrocarbon formation. The reported assay system provides a useful tool for mechanistic

Gun Safety (For Kids)

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Gun Safety KidsHealth / For Kids / Gun Safety What's in ... from guns outside the home. If You Have Guns in Your Home If your parents keep guns ...

State Gun Policy and Cross-State Externalities: Evidence from Crime Gun Tracing

OpenAIRE

Brian Knight

2013-01-01

This paper provides a theoretical and empirical analysis of cross-state externalities associated with gun regulations in the context of the gun trafficking market. Using gun tracing data, which identify the source state for crime guns recovered in destination states, we find that firearms in this market tend to flow from states with weak gun laws to states with strict gun laws, satisfying a necessary condition for the existence of cross-state externalities in the theoretical model. We also fi...

Temporal association between federal gun laws and the diversion of guns to criminals in Milwaukee.

Science.gov (United States)

Webster, Daniel W; Vernick, Jon S; Bulzacchelli, Maria T; Vittes, Katherine A

2012-02-01

The practices of licensed gun dealers can threaten the safety of urban residents by facilitating the diversion of guns to criminals. In 2003, changes to federal law shielded gun dealers from the release of gun trace data and provided other protections to gun dealers. The 14-month period during which the dealer did not sell junk guns was associated with a 68% reduction in the diversion of guns to criminals within a year of sale by the dealer and a 43% increase in guns diverted to criminals following sales by other dealers. The laws were associated with a 203% increase in the number of guns diverted to criminals within a year of sale by the gun store, which was the focus of this study. Policies which affect gun dealer accountability appeared to influence the diversion of guns to criminals.

Defect kinetics in spinels: Long-time simulations of MgAl2O4, MgGa2O4, and MgIn2O4

International Nuclear Information System (INIS)

Uberuaga, B. P.; Voter, A. F.; Sickafus, K. E.; Bacorisen, D.; Smith, Roger; Ball, J. A.; Grimes, R. W.

2007-01-01

Building upon work in which we examined defect production and stability in spinels, we now turn to defect kinetics. Using temperature accelerated dynamics (TAD), we characterize the kinetics of defects in three spinel oxides: magnesium aluminate MgAl 2 O 4 , magnesium gallate MgGa 2 O 4 , and magnesium indate MgIn 2 O 4 . These materials have varying tendencies to disorder on the cation sublattices. In order to understand chemical composition effects, we first examine defect kinetics in perfectly ordered, or normal, spinels, focusing on point defects on each sublattice. We then examine the role that cation disorder has on defect mobility. Using TAD, we find that disorder creates local environments which strongly trap point defects, effectively reducing their mobility. We explore the consequences of this trapping via kinetic Monte Carlo (KMC) simulations on the oxygen vacancy (V O ) in MgGa 2 O 4 , finding that V O mobility is directly related to the degree of inversion in the system

Color formation in nitrite-free dried hams as related to Zn-protoporphyrin IX and Zn-chelatase activity.

Science.gov (United States)

Parolari, Giovanni; Benedini, Riccardo; Toscani, Tania

2009-08-01

The development of red pigment Zn-protoporphyrin IX (ZPP) in nitrite-free Parma hams was investigated in 5 leg muscles at several stages of processing and the activity of muscle Zn-chelatase was concurrently assayed for its potential role in ZPP formation. A steady increase of the pigment was observed throughout the manufacturing stages at mild temperatures while no development was observed during the prior cold resting phase. The enzyme was partly inactivated according to a muscle-dependent pattern, resulting in similar ZPP contents, hence color, in finished hams. It is concluded that enzyme-dependent synthesis of ZPP in nitrite-free dried hams contributes to color development, enabling muscles in dried hams to become more similar in redness than in green thighs. Therefore, checking raw meat for the enzyme content may be a means to control color formation in nitrite-free dry-cured meat derivatives.

God and Guns: Examining Religious Influences on Gun Control Attitudes in the United States

Directory of Open Access Journals (Sweden)

Stephen M. Merino

2018-06-01

Full Text Available Mass shootings in the United States have generated significant media coverage and public concern, invigorating debates over gun control. Media coverage and academic research on gun control attitudes and reactions to mass shootings have paid little attention to the role of religion. Recent research sheds light on the complex relationship between religion and guns, including higher rates of gun ownership and stronger opposition to gun control among white evangelical Protestants. Using nationally representative survey data, this study examines the relationship between religious identity, gun ownership, and support for a range of gun control policies, including proposed remedies for preventing mass shootings. Compared with individuals from other religious traditions, evangelical Protestants are most opposed to stricter gun control laws and enforcement, even with statistical controls for gun ownership and demographic characteristics. Rather, they favor individualistic solutions and putting more emphasis on religious values in their social surroundings. I discuss how these findings reflect the cultural tools evangelical Protestants use to construct their understandings of social problems, including gun violence, and the broader implications for gun policy in the United States.

Thermoluminescence kinetic analysis and dosimetry features of MgSO4:Dy and MgSO4:Cu nano-rods

International Nuclear Information System (INIS)

Zahedifar, M.; Almasifard, F.; Sadeghi, E.; Biroon, M. Kashefi; Ramazani- Moghaddam-Arani, A.

2016-01-01

MgSO 4 :Dy and MgSO 4 :Cu nano-rods (NRs) were synthesized for the first time by semi co- precipitation method. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) were utilized for sample characterization. The optimum amount of dysprosium and copper concentrations were obtained both at 0.1 mol% in MgSO 4 :Dy and MgSO 4 :Cu NRs. T m -T stop and computerized glow curve deconvolution (CGCD) methods were used for identifying the number of component glow peaks and kinetic parameters of the synthesized NRs. Initial rise and variable heating rate methods were also used to ensure the reliability of obtained kinetic parameters. Results show that the TL sensitivity of MgSO 4 :Dy is about 7 times more than that of magnesium sulfate doped with Cu. The TL dose response of MgSO 4 :Dy and MgSO 4 :Cu NRs are linear up to absorbed dose of 10 KGy. Other TL dosimetry characteristics of the produced NRs are also presented and discussed. - Highlights: • MgSO4:Dy and MgSO4:Cu nano-rods were synthesized for the first time. • Thermoluminescence dosimetry properties were studied. • The nano-phosphors showed linear dose response up to very high dose levels. • The synthesized nano-rods have potential application for high dose dosimetry.

Gun Theft and Crime.

Science.gov (United States)

Cook, Philip J

2018-06-01

Some law enforcement officials and other observers have asserted that theft is the primary source of guns to crime. In fact, the role of theft in supplying the guns used in robbery, assault, and murder is unknown, and current evidence provides little guidance about whether an effective program to reduce gun theft would reduce gun violence. The current article analyzes publicly available national data on gun theft together with a unique data set for Chicago. The results tend to support a conclusion that stolen guns play only a minor role in crime. First, publicly available data are used to calculate that thefts are only about 1% of all gun transactions nationwide. Second, an analysis of original data from Chicago demonstrates that less than 3% of crime guns recovered by the police have been reported stolen to the Chicago Police Department (CPD). If a gun is reported stolen, there is a 20% chance that it will be recovered, usually in conjunction with an arrest for illegal carrying. Less than half of those picked up with a stolen gun have a criminal record that includes violent offenses. Third, results from surveys of convicted criminals, both nationally and in Chicago, suggest that it is rare for respondents to have stolen the gun used in their most recent crime. The data on which these results are based have various shortcomings. A research agenda is proposed that would provide more certainty about the role of theft.

Guns and Violence. Current Controversies.

Science.gov (United States)

Kim, Henny H., Ed.

This book focuses on gun violence and gun control, presenting both sides of arguments about firearms ownership and gun control. Each of five chapters poses a question about gun control and provides answers for both sides of the question. The following essays are included: (1) "Gun Violence Is Becoming an Epidemic" (Bob Herbert); (2) "Gun Violence…

The ternary system K2SO4MgSO4CaSO4

Science.gov (United States)

Rowe, J.J.; Morey, G.W.; Silber, C.C.

1967-01-01

Melting and subsolidus relations in the system K2SO4MgSO4CaSO4 were studied using heating-cooling curves, differential thermal analysis, optics, X-ray diffraction at room and high temperatures and by quenching techniques. Previous investigators were unable to study the binary MgSO4CaSO4 system and the adjacent area in the ternary system because of the decomposition of MgSO4 and CaSO4 at high temperatures. This problem was partly overcome by a novel sealed-tube quenching method, by hydrothermal synthesis, and by long-time heating in the solidus. As a result of this study, we found: (1) a new compound, CaSO4??3MgSO4 (m.p. 1201??C) with a field extending into the ternary system; (2) a high temperature form of MgSO4 with a sluggishly reversible inversion. An X-ray diffraction pattern for this polymorphic form is given; (3) the inversion of ??-CaSO4 (anhydrite) to ??-CaSO4 at 1195??C, in agreement with grahmann; (1) (4) the melting point of MgSO4 is 1136??C and that of CaSO4 is 1462??C (using sealed tube methods to prevent decomposition of the sulphates); (5) calcium langbeinite (K2SO4??2CaSO4) is the only compound in the K2SO4CaSO4 binary system. This resolved discrepancies in the results of previous investigators; (6) a continuous solid solution series between congruently melting K2SOP4??2MgSO4 (langbeinite) and incongruently melting K2SO4??2CaSO4 (calcium langbeinite); (7) the liquidus in the ternary system consists of primary phase fields of K2SO4, MgSO4, CaSO4, langbeinite-calcium langbeinite solid solution, and CaSO4??3MgSO4. The CaSO4 field extends over a large portion of the system. Previously reported fields for the compounds (K2SO4??MgSO4??nCaSO4), K2SO4??3CaSO4 and K2SO4??CaSO4 were not found; (8) a minimum in the ternary system at: 740??C, 25% MgSO4, 6% CaSO4, 69% K2SO4; and ternary eutectics at 882??C, 49% MgSO4, 19% CaSO4, 32% K2SO4; and 880??, 67??5% MgSO4, 5% CaSO4, 27??5% K2SO4. ?? 1967.

Modeling internal ballistics of gas combustion guns.

Science.gov (United States)

Schorge, Volker; Grossjohann, Rico; Schönekess, Holger C; Herbst, Jörg; Bockholdt, Britta; Ekkernkamp, Axel; Frank, Matthias

2016-05-01

Potato guns are popular homemade guns which work on the principle of gas combustion. They are usually constructed for recreational rather than criminal purposes. Yet some serious injuries and fatalities due to these guns are reported. As information on the internal ballistics of homemade gas combustion-powered guns is scarce, it is the aim of this work to provide an experimental model of the internal ballistics of these devices and to investigate their basic physical parameters. A gas combustion gun was constructed with a steel tube as the main component. Gas/air mixtures of acetylene, hydrogen, and ethylene were used as propellants for discharging a 46-mm caliber test projectile. Gas pressure in the combustion chamber was captured with a piezoelectric pressure sensor. Projectile velocity was measured with a ballistic speed measurement system. The maximum gas pressure, the maximum rate of pressure rise, the time parameters of the pressure curve, and the velocity and path of the projectile through the barrel as a function of time were determined according to the pressure-time curve. The maximum gas pressure was measured to be between 1.4 bar (ethylene) and 4.5 bar (acetylene). The highest maximum rate of pressure rise was determined for hydrogen at (dp/dt)max = 607 bar/s. The muzzle energy was calculated to be between 67 J (ethylene) and 204 J (acetylene). To conclude, this work provides basic information on the internal ballistics of homemade gas combustion guns. The risk of injury to the operator or bystanders is high, because accidental explosions of the gun due to the high-pressure rise during combustion of the gas/air mixture may occur.

RF Electron Gun with Driven Plasma Cathode

CERN Document Server

Khodak, Igor

2005-01-01

It's known that RF guns with plasma cathodes based on solid-state dielectrics are able to generate an intense electron beam. In this paper we describe results of experimental investigation of the single cavity S-band RF gun with driven plasma cathode. The experimental sample of the cathode based on ferroelectric ceramics has been designed. Special design of the cathode permits to separate spatially processes of plasma development and electron acceleration. It has been obtained at RF gun output electron beam with particle energy ~500 keV, pulse current of 4 A and pulse duration of 80 ns. Results of experimental study of beam parameters are referred in. The gun is purposed to be applied as the intense electron beam source for electron linacs.

Gun Sales. Firearm Facts.

Science.gov (United States)

Duker, Laurie, Ed.

Minimal federal regulations on firearm sales have facilitated the proliferation of guns, gun owners, and gun dealers in the United States. This fact sheet offers data on the growing number of firearm dealers, the relative ease of obtaining and keeping a license to sell guns from the Federal Bureau of Alcohol, Tobacco, and Firearms, the lack of…

Characterization and optimization of the HyperV PLX- α coaxial-gun plasma jet

Science.gov (United States)

Case, Andrew; Brockington, Sam; Cruz, Edward; Witherspoon, F. Douglas

2017-10-01

We present results from characterizing and optimizing performance of the contoured gap coaxial plasma guns under development for the ARPA-E Accelerating Low-Cost Plasma Heating And Assembly (ALPHA) program. Plasma jet diagnostics include fast photodiodes for velocimetry and interferometry for line integrated density. Additionally we present results from spectroscopy, both time resolved high resolution spectroscopy using a novel detector and time integrated survey spectroscopy, for measurements of velocity and temperature as well as impurities. Fast imaging gives plume geometry and time integrated imaging gives overall light emission. Results from a novel long record length camera developed by HyperV will also be presented. Experimental results are compared to the desired target parameters for the plasma jets. The target values for the plasmoid are velocity of 50 km/s, mass of 3.5 mg, and length of 10 cm. The best results so far from the exploration of parameter space for gun operation are: 4 mg at >50 km/s, with a length of 10 cm. Peak axial density 34 cm downstream from the muzzle is 2 ×1016 cm-3. This work supported by the ARPA-E ALPHA Program under contract DE-AR0000566.

Acceleration of small, light projectiles (including hydrogen isotopes) to high speeds using a two-stage light gas gun

International Nuclear Information System (INIS)

Combs, S.K.; Foust, C.R.; Gouge, M.J.; Milora, S.L.

1989-01-01

Small, light projectiles have been accelerated to high speeds using a two-stage light gas gun at Oak Ridge National Laboratory. With 35-mg plastic projectiles (4 mm in diameter), speeds of up to 4.5 km/s have been recorded. The ''pipe gun'' technique for freezing hydrogen isotopes in situ in the gun barrel has been used to accelerate deuterium pellets (nominal diameter of 4 mm) to velocities of up to 2.85 km/s. The primary application of this technology is for plasma fueling of fusion devices via pellet injection of hydrogen isotopes. Conventional pellet injectors are limited to pellet speeds in the range 1-2 km/s. Higher velocities are desirable for plasma fueling applications, and the two-stage pneumatic technique offers performance in a higher velocity regime. However, experimental results indicate that the use of sabots to encase the cryogenic pellets and protect them for the high peak pressures will be required to reliably attain intact pellets at speeds of ∼3 km/s or greater. In some limited tests, lithium hydride pellets were accelerated to speeds of up to 4.2 km/s. Also, repetitive operation of the two-stage gun (four plastic pellets fired at ∼0.5 Hz) was demonstrated for the first time in preliminary tests. The equipment and operation are described, and experimental results and some comparisons with a theoretical model are presented. 17 refs., 6 figs., 2 tabs

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase

Science.gov (United States)

Hernandez-Ortega, Aitor; Quesne, Matthew G.; Bui, Soi; Heuts, Dominic P. H. M.; Steiner, Roberto A.; Heyes, Derren J.; de Visser, Sam P.; Scrutton, Nigel S.

2014-01-01

Dioxygenases catalyze a diverse range of chemical reactions that involve the incorporation of oxygen into a substrate and typically use a transition metal or organic cofactor for reaction. Bacterial (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HOD) belongs to a class of oxygenases able to catalyze this energetically unfavorable reaction without any cofactor. In the quinaldine metabolic pathway, HOD breaks down its natural N-heteroaromatic substrate using a mechanism that is still incompletely understood. Experimental and computational approaches were combined to study the initial step of the catalytic cycle. We have investigated the role of the active site His-251/Asp-126 dyad, proposed to be involved in substrate hydroxyl group deprotonation, a critical requirement for subsequent oxygen reaction. The pH profiles obtained under steady-state conditions for the H251A and D126A variants show a strong pH effect on their kcat and kcat/Km constants, with a decrease in kcat/Km of 5500- and 9-fold at pH 10.5, respectively. Substrate deprotonation studies under transient-state conditions show that this step is not rate-limiting and yield a pKa value of ∼7.2 for WT HOD. A large solvent isotope effect was found, and the pKa value was shifted to ∼8.3 in D2O. Crystallographic and computational studies reveal that the mutations have a minor effect on substrate positioning. Computational work shows that both His-251 and Asp-126 are essential for the proton transfer driving force of the initial reaction. This multidisciplinary study offers unambiguous support to the view that substrate deprotonation, driven by the His/Asp dyad, is an essential requirement for its activation. PMID:24482238

Function of bunching segment in multi-cell RF gun

International Nuclear Information System (INIS)

Yang Xingfan; Xu Zhou Liu Xisan

2001-01-01

With a bunching segment and a shortened first cell, the 4 + 1/2 cell RF gun produced in CAEP has been proved experimentally to be effective in reducing electron back bombardment. The analysis of the electric field distribution and electron motion in bunching segment of multi-cell RF gun is presented. The electron capture efficiency and electron trajectory with different initial phase are calculated using Runge-Kutta method. The function of the bunching segment is discussed. The calculated parameters of the 4 + 1/2 cell RF gun agree well with the experimental results

Response of potato to drip and gun irrigation systems

DEFF Research Database (Denmark)

Zhenjiang, Zhou; Andersen, Mathias Neumann; Plauborg, Finn

2015-01-01

The objective of this study was to evaluate effects of different irrigation and N fertilization regimes by gun irrigation and drip-fertigation on potato production, and subsequently optimize the supply of water and N fertilizer to the growth condition of the specific season and minimize nitrate......-fertigation system (DFdsNds) and two gun irrigation systems (GIdsN120 and GIaN120) to display the differences on growth, yield and water use efficiency of potato. All treatments were irrigated according to model simulated soil water content. For fertilization all treatments received a basic dressing at planting of P......, K, Mg and micronutrients, and in addition 120 kg N/ha in the gun irrigated treatments and 36 kg N/ha in the drip-fertigated. For the latter, portion of 20 kg N/ha was applied whenever plant N concentration approached a critical value as simulated by the Daisy model. As a result differences in soil...

Racism, gun ownership and gun control: biased attitudes in US whites may influence policy decisions.

Science.gov (United States)

O'Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

2013-01-01

Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification) were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58) was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46), which likely represents self-interest in retaining property (guns). Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites' paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions.

Gun possession among American youth: a discovery-based approach to understand gun violence.

Science.gov (United States)

Ruggles, Kelly V; Rajan, Sonali

2014-01-01

To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011). Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1) visualize and assess which behaviors frequently co-occur and 2) evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1) physical activity and nutrition; 2) disordered eating, suicide and sexual violence; 3) weapon carrying and physical safety; 4) alcohol, marijuana and cigarette use; 5) drug use on school property and 6) overall drug use. Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

Gun possession among American youth: a discovery-based approach to understand gun violence.

Directory of Open Access Journals (Sweden)

Kelly V Ruggles

Full Text Available OBJECTIVE: To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. RESULTS: Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011. Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1 visualize and assess which behaviors frequently co-occur and 2 evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1 physical activity and nutrition; 2 disordered eating, suicide and sexual violence; 3 weapon carrying and physical safety; 4 alcohol, marijuana and cigarette use; 5 drug use on school property and 6 overall drug use. CONCLUSIONS: Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

Simple light gas guns for hypervelocity studies

International Nuclear Information System (INIS)

Combs, S.K.; Haselton, H.H.; Milora, S.L.

1990-01-01

Two-stage light guns are used extensively in hypervelocity research. The applications of this technology include impact studies and special materials development. Oak Ridge National Laboratory (ORNL) has developed two-stage guns that accelerate small projectiles (4-mm nominal diameter) to velocities of up to ∼5 km/s. These guns are relatively small and simple (thus, easy to operate), allowing a significant number of test shots to be carried out and data accumulated in a short time. Materials that have been used for projectiles include plastics, frozen isotopes of hydrogen, and lithium hydride. One gun has been used to demonstrate repetitive operation at a rate of 0.7 Hz; and, with a few design improvements, it appears capable of performing at firing frequencies of 1--2 Hz. A schematic of ORNL two-stage device is shown below. Unlike most such devices, no rupture disks are used. Instead, a fast valve (high-flow type) initiates the acceleration process in the first stage. Projectiles can be loaded into the gun breech via the slide mechanism; this action has been automated which allows repetitive firing. Alternatively, the device is equipped with ''pipe gun'' apparatus in which gas can be frozen in situ in the gun barrel to form the projectile. This equipment operates with high reliability and is well suited for small-scale testing at high velocity. 17 refs., 6 figs., 2 tabs

Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development☆

Science.gov (United States)

Neilson, Karen M.; Abbruzzesse, Genevieve; Kenyon, Kristy; Bartolo, Vanessa; Krohn, Patrick; Alfandari, Dominique; Moody, Sally A.

2016-01-01

Mutations in SIX1 and in its co-factor, EYA1, underlie Branchiootorenal Spectrum disorder (BOS), which is characterized by variable branchial arch, otic and kidney malformations. However, mutations in these two genes are identified in only half of patients. We screened for other potential co-factors, and herein characterize one of them, Pa2G4 (aka Ebp1/Plfap). In human embryonic kidney cells, Pa2G4 binds to Six1 and interferes with the Six1-Eya1 complex. In Xenopus embryos, knock-down of Pa2G4 leads to down-regulation of neural border zone, neural crest and cranial placode genes, and concomitant expansion of neural plate genes. Gain-of-function leads to a broader neural border zone, expanded neural crest and altered cranial placode domains. In loss-of-function assays, the later developing otocyst is reduced in size, which impacts gene expression. In contrast, the size of the otocyst in gain-of-function assays is not changed but the expression domains of several otocyst genes are reduced. Together these findings establish an interaction between Pa2G4 and Six1, and demonstrate that it has an important role in the development of tissues affected in BOS. Thereby, we suggest that pa2g4 is a potential candidate gene for BOS. PMID:27940157

Quantum mechanics/molecular mechanics studies on the mechanism of action of cofactor pyridoxal 5'-phosphate in ornithine 4,5-aminomutase.

Science.gov (United States)

Pang, Jiayun; Scrutton, Nigel S; Sutcliffe, Michael J

2014-09-01

A computational study was performed on the experimentally elusive cyclisation step in the cofactor pyridoxal 5'-phosphate (PLP)-dependent D-ornithine 4,5-aminomutase (OAM)-catalysed reaction. Calculations using both model systems and a combined quantum mechanics/molecular mechanics approach suggest that regulation of the cyclic radical intermediate is achieved through the synergy of the intrinsic catalytic power of cofactor PLP and the active site of the enzyme. The captodative effect of PLP is balanced by an enzyme active site that controls the deprotonation of both the pyridine nitrogen atom (N1) and the Schiff-base nitrogen atom (N2). Furthermore, electrostatic interactions between the terminal carboxylate and amino groups of the substrate and Arg297 and Glu81 impose substantial "strain" energy on the orientation of the cyclic intermediate to control its trajectory. In addition the "strain" energy, which appears to be sensitive to both the number of carbon atoms in the substrate/analogue and the position of the radical intermediates, may play a key role in controlling the transition of the enzyme from the closed to the open state. Our results provide new insights into several aspects of the radical mechanism in aminomutase catalysis and broaden our understanding of cofactor PLP-dependent reactions. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Racism, gun ownership and gun control: biased attitudes in US whites may influence policy decisions.

Directory of Open Access Journals (Sweden)

Kerry O'Brien

Full Text Available OBJECTIVE: Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty. This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. METHOD: The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. RESULTS: After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58 was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46, which likely represents self-interest in retaining property (guns. CONCLUSIONS: Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites' paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions.

Racism, Gun Ownership and Gun Control: Biased Attitudes in US Whites May Influence Policy Decisions

Science.gov (United States)

O’Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

2013-01-01

Objective Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. Method The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification) were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. Results After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58) was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46), which likely represents self-interest in retaining property (guns). Conclusions Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites’ paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions. PMID:24204867

Gun power source for electron gun of 3 MeV DC accelerator

International Nuclear Information System (INIS)

Dewangan, S.; Sharma, D.K.; Nanu, K.

2011-01-01

In DC electron beam accelerator electron gun is situated at high voltage terminal which requires constant power irrespective of beam energy. Floating power source is required for gun. This paper describes the scheme of static gun power source derived from parallel coupled voltage multiplier column. (author)

Electron guns for accelerators

International Nuclear Information System (INIS)

Rangarajan, L.M.; Mahadevan, S.; Ramamurthi, S.S.

1995-01-01

The high voltage, high current electron guns developed elsewhere for Linacs are based on cathode pulsing with direct emitting cathodes. Our grid pulsed triode gun employs indirect emitting cathode pellet under electron bombardment or a direct cathode emitter. Electron beam from the gun is injected to the accelerator guide at 40 kV and pulse duration is 2.8μsec. The gun is limited to axially symmetric geometry and electron optical design is optimized by computer programming. The gun with a water cooled Faraday cup is connected to a vacuum system comprising of a sputter ion pump and sorption pump. Working pressure is 1x10 -6 Pa. Gun is designed to be baked as an assembly at temperatures of 400 degC while vacuum processing. Materials are therefore restricted to refractory metals, SS, OFHC copper and all the electrodes are housed inside a ceramic tube. Lower Z graphite is used as a base material of Faraday cup. Grid is non-intercepting modulator anode, a new feature introduced, as compared to meshed grid system by others. CAT gun delivers 160 mA current pulses at 40 kV and its working characteristics such as perveance, emittance and beam radius compare well with SLAC and Hermosa guns. The above guns can be used for electron beam machines such as medical Linacs, industrial accelerators and EB welding equipment. (author). 2 refs., 2 figs

Armed To Learn: Aiming At California K 12 School Gun Policy

Science.gov (United States)

2016-03-01

AIMING AT CALIFORNIA K-12 SCHOOL GUN POLICY by Catherine Wilson Jones March 2016 Thesis Co-Advisors: Kathleen Kiernan John Rollins...Master’s thesis 4. TITLE AND SUBTITLE ARMED TO LEARN: AIMING AT CALIFORNIA K-12 SCHOOL GUN POLICY 5. FUNDING NUMBERS 6. AUTHOR(S) Catherine...gap in viewpoints between gun control advocates who want tighter gun control and constitutionalists who believe as strongly in the Second Amendment

Transcriptome Analysis of Manganese-deficient Chlamydomonas reinhardtii Provides Insight on the Chlorophyll Biosynthesis Pathway

Energy Technology Data Exchange (ETDEWEB)

Lockhart, Ainsley; Zvenigorodsky, Natasha; Pedraza, Mary Ann; Lindquist, Erika

2011-08-11

The biosynthesis of chlorophyll and other tetrapyrroles is a vital but poorly understood process. Recent genomic advances with the unicellular green algae Chlamydomonas reinhardtii have created opportunity to more closely examine the mechanisms of the chlorophyll biosynthesis pathway via transcriptome analysis. Manganese is a nutrient of interest for complex reactions because of its multiple stable oxidation states and role in molecular oxygen coordination. C. reinhardtii was cultured in Manganese-deplete Tris-acetate-phosphate (TAP) media for 24 hours and used to create cDNA libraries for sequencing using Illumina TruSeq technology. Transcriptome analysis provided intriguing insight on possible regulatory mechanisms in the pathway. Evidence supports similarities of GTR (Glutamyl-tRNA synthase) to its Chlorella vulgaris homolog in terms of Mn requirements. Data was also suggestive of Mn-related compensatory up-regulation for pathway proteins CHLH1 (Manganese Chelatase), GUN4 (Magnesium chelatase activating protein), and POR1 (Light-dependent protochlorophyllide reductase). Intriguingly, data suggests possible reciprocal expression of oxygen dependent CPX1 (coproporphyrinogen III oxidase) and oxygen independent CPX2. Further analysis using RT-PCR could provide compelling evidence for several novel regulatory mechanisms in the chlorophyll biosynthesis pathway.

Co-axial electrodes gun characteristics

International Nuclear Information System (INIS)

Masoud, M.M.; Soliman, H.M.

1981-01-01

A coaxial electrodes gun is constructed with inner electrode diameter of 3.2 cm; outer electrode diameter of 6.6 cm and length of 25 cm it is connected to a condenser bank which delivers 4 K joule stored energy. The maximum power of the discharge is equal to 4.5x10 4 K watt; for 5 KV charging voltage. The inductance showed two main peak values of 0.257μH and 0.27μH. Theoretical calculations using one-dimension-single fluid model is μ sed, which shows that the maximum acceleration is at 0.5 sec, and the gas breakdown takes place at the gun breech; at the start of the discharge, will leave the gun after 1.625μ sec, also the drift velocity, the force and the magnetic field are given. The measured results show quite reasonable agreement with the calculations for most of the results, and the position of the plasma sheath inside the gun slightly deviated from the theoretical calculations due to viscosity and wall interaction, as well as other parameters which did not be take into consideration. The plasma current density of the sheath has its maximum value at Z=18 cm, the plasma will leave the coaxial source after 1.5μ sec, from the start of the discharge, which conferms with the theoretical model. Resistance of the gas between the electrodes, changes with time according to the particle injected from this source, and the maximum efficiency of the installation for charging voltage 5kV and pressure 80μ Hg is at approx.=10μ sec and 20.5μ sec

An rf modulated electron gun pulser for linacs

International Nuclear Information System (INIS)

Legg, R.; Hartline, R.

1991-01-01

Present linac injector designs often make use of sub-harmonic prebuncher cavities to properly bunch the electron beam before injection into a buncher and subsequent accelerating cavities. This paper proposes an rf modulated thermionic gun which would allow the sub-harmonic buncher to be eliminated from the injector. The performance parameters for the proposed gun are 120 kV operating voltage, macropulse duration-single pulse mode 2 nsec, multiple pulse mode 100 nsec, rf modularing frequency 500 MHz, charge per micropulse 0.4 nC, macropulse repetition frequency 10 Hz (max). The gun pulser uses a grid modulated planar triode to drive the gun cathode. The grid driver takes advantage of recently developed modular CATV rf drivers, high performance solid state pulser devices, and high-frequency fiber optic transmitters for telecommunications. Design details are presented with associated SPICE runs simulating operation of the gun

Carbon plasma gun

International Nuclear Information System (INIS)

Mendel, C.W. Jr.; Zagar, D.M.; Mills, G.S.; Humphries, S. Jr.; Goldstein, S.A.

1980-01-01

A family of plasma guns supplying highly ionized carbon plasma is described. The guns are simple and inexpensive to construct and are pulsed by small capacitor banks of a few hundred joules. The output consists of 10 17 --10 18 multiply ionized carbon ions traveling at about 10 7 cm/s. Neutral output is very low and arrives well after the ionized carbon. The guns and pulsers are very reliable

A numerical study of emittance growths in RF guns

CERN Document Server

Masuda, K; Sobajima, M; Kitagaki, J; Ohnishi, M; Toku, H; Yoshikawa, K

1999-01-01

A beam with greatly reduced emittance is required for further improvements of FELs, in particular, for FELs of shorter wavelengths, and of narrower bandwidths. From this viewpoint, the BNL/SLAC/UCLA 1.6-cell S-band photocathode RF gun performance characteristics were calculated, first in order to evaluate what may contribute to the emittance growths in photocathode RF guns. We developed an RF gun to produce an electron beam with an extremely low emittance, by using a 2-D simulation code. It is found that, by optimizing the laser injection phase, the drive laser spot radius and the cavity shape around the laser spot, the beam emittance by the 1.6-cell RF gun can be greatly reduced to 2.1 pi mm mrad, from the previous 4.4 pi mm mrad of the original shape.

Carbon Nanotube Electron Gun

Science.gov (United States)

Nguyen, Cattien V. (Inventor); Ribaya, Bryan P. (Inventor)

2013-01-01

An electron gun, an electron source for an electron gun, an extractor for an electron gun, and a respective method for producing the electron gun, the electron source and the extractor are disclosed. Embodiments provide an electron source utilizing a carbon nanotube (CNT) bonded to a substrate for increased stability, reliability, and durability. An extractor with an aperture in a conductive material is used to extract electrons from the electron source, where the aperture may substantially align with the CNT of the electron source when the extractor and electron source are mated to form the electron gun. The electron source and extractor may have alignment features for aligning the electron source and the extractor, thereby bringing the aperture and CNT into substantial alignment when assembled. The alignment features may provide and maintain this alignment during operation to improve the field emission characteristics and overall system stability of the electron gun.

Co-factor activated recombinant adenovirus proteinases

Science.gov (United States)

Anderson, Carl W.; Mangel, Walter F.

1996-08-06

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Gun Violence, Mental Illness, And Laws That Prohibit Gun Possession: Evidence From Two Florida Counties.

Science.gov (United States)

Swanson, Jeffrey W; Easter, Michele M; Robertson, Allison G; Swartz, Marvin S; Alanis-Hirsch, Kelly; Moseley, Daniel; Dion, Charles; Petrila, John

2016-06-01

Gun violence kills about ninety people every day in the United States, a toll measured in wasted and ruined lives and with an annual economic price tag exceeding $200 billion. Some policy makers suggest that reforming mental health care systems and improving point-of-purchase background checks to keep guns from mentally disturbed people will address the problem. Epidemiological research shows that serious mental illness contributes little to the risk of interpersonal violence but is a strong factor in suicide, which accounts for most firearm fatalities. Meanwhile, the effectiveness of gun restrictions focused on mental illness remains poorly understood. This article examines gun-related suicide and violent crime in people with serious mental illnesses, and whether legal restrictions on firearm sales to people with a history of mental health adjudication are effective in preventing gun violence. Among the study population in two large Florida counties, we found that 62 percent of violent gun crime arrests and 28 percent of gun suicides involved individuals not legally permitted to have a gun at the time. Suggested policy reforms include enacting risk-based gun removal laws and prohibiting guns from people involuntarily detained in short-term psychiatric hospitalizations. Project HOPE—The People-to-People Health Foundation, Inc.

Sanoli Gun

Indian Academy of Sciences (India)

Home; Journals; Proceedings – Mathematical Sciences. Sanoli Gun. Articles written in Proceedings – Mathematical Sciences. Volume 119 Issue 3 June 2009 pp 275-281. Remarks on some Zero-Sum Theorems · S D Adhikari Sanoli Gun Purusottam Rath · More Details Abstract Fulltext PDF. In the present paper, we give a ...

Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells.

Science.gov (United States)

Philpott, Caroline C; Ryu, Moon-Suhn; Frey, Avery; Patel, Sarju

2017-08-04

Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors. Iron cofactors include heme, iron-sulfur clusters, and simple iron ions. Poly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytosolic/nuclear compartment, binding iron at import and delivering it to enzymes, for storage (ferritin) and export (ferroportin). Ferritin iron is mobilized by autophagy through the cargo receptor, nuclear co-activator 4. The monothiol glutaredoxin Glrx3 and BolA2 function as a [2Fe-2S] chaperone complex. These proteins form a core system of cytosolic iron cofactor chaperones in mammalian cells. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo†

Science.gov (United States)

Cotruvo, Joseph A.; Stubbe, JoAnne

2011-01-01

Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5′-diphosphates to deoxynucleoside 5′-diphosphates in iron-limited and oxidative stress conditions. We have recently demonstrated in vitro that this RNR is active with both diferric-tyrosyl radical (FeIII2-Y•) and dimanganese(III)-Y• (MnIII2-Y•) cofactors in the β2 subunit, NrdF [Cotruvo J.A., Jr. and Stubbe J., Biochemistry (2010) 49, 1297–1309]. Here we demonstrate, by purification of this protein from its endogenous levels in an E. coli strain deficient in its five known iron uptake pathways and grown under iron-limited conditions, that the MnIII2-Y• cofactor is assembled in vivo. This is the first definitive determination of the active cofactor of a class Ib RNR purified from its native organism without overexpression. From 88 g of cell paste, 150 μg of NrdF was isolated with ~95% purity, with 0.2 Y•/β2, 0.9 Mn/β2, and a specific activity of 720 nmol/min/mg. In these conditions, the class Ib RNR is the primary active RNR in the cell. Our results strongly suggest that E. coli NrdF is an obligate manganese protein in vivo and that the MnIII2-Y• cofactor assembly pathway we have identified in vitro involving the flavodoxin-like protein NrdI, present inside the cell at catalytic levels, is operative in vivo. PMID:21250660

Goods for Guns--the use of a gun buyback as an injury prevention/community education tool.

Science.gov (United States)

McGuire, Margaret; Manno, Mariann; Rook, Allison; Maranda, Louise; Renaud, Elizabeth; DeRoss, Anthony; Hirsh, Michael

2011-11-01

US children aged between 5 years and 14 years have a rate of gun-related homicide 17 times higher and a rate of gun-related suicide and unintentional firearm injury 10 times higher than other developed countries. Gun buyback programs have been criticized as ineffective interventions in decreasing violence. The Injury Free Coalition for Kids-Worcester (IFCK-W) Goods for Guns buyback is a multipronged approach to address these concerns and to reduce the number of firearms in the community. The IFCK-W buyback program is funded by corporate sponsors, grants, and individual donations. Citizens are instructed to transport guns, ammunition, and weapons safely to police headquarters on two Saturdays in December. Participants are guaranteed anonymity by the District Attorney's office and receive gift certificates for operable guns. Trained volunteers administer an anonymous survey to willing participants. Individuals who disclose having unsafely stored guns remaining at home receive educational counseling and trigger locks. Guns and ammunition are destroyed at a later time in a gun crushing ceremony. Since 2002, 1,861 guns (444 rifle/shotgun, 738 pistol/revolver, and 679 automatic/semiautomatic) have been collected at a cost of $99,250 (average, $53/gun). Seven hundred ten people have surrendered firearms, 534 surveys have been administered, and ≈ 75 trigger locks have been distributed per year. IFCK-W Goods for Guns is a relatively inexpensive injury prevention model program that removes unwanted firearms from homes, raises community awareness about gun safety, and provides high-risk individuals with trigger locks and educational counseling.

Emittance growth in laser-driven RF electron guns

International Nuclear Information System (INIS)

Kim, K.J.

1989-01-01

A simple analysis for the evolution of the electron-beam phase space distribution in laser-driven rf guns is presented. In particular, formulas are derived for the transverse and longitudinal emittances at the exit of the gun. The results are compared and found to agree well with those from simulation. (Author). 9 refs.; 4 figs

The Effects of Cueing and Framing on Youth Attitudes towards Gun Control and Gun Rights

Directory of Open Access Journals (Sweden)

Stephen Wu

2018-02-01

Full Text Available I analyze attitudes towards gun control from a recent survey of American high school students. For students who most closely identify as Republicans, cueing them to think about prior school shootings increases their agreement that armed staff in schools will improve safety and arming citizens will reduce risk of mass shootings. For those identifying as Democrats and Independents, providing them with selective information that certain states have loose gun control laws and low rates of gun violence makes them more supportive of gun rights. For Republicans, providing selective information that certain states have loose gun control laws and high rates of gun violence makes them less supportive of gun rights. These results suggest that emotional cues may exacerbate a priori biases, while informational cues may be more likely to change people’s minds about firearm policies.

Simplified pipe gun

International Nuclear Information System (INIS)

Sorensen, H.; Nordskov, A.; Sass, B.; Visler, T.

1987-01-01

A simplified version of a deuterium pellet gun based on the pipe gun principle is described. The pipe gun is made from a continuous tube of stainless steel and gas is fed in from the muzzle end only. It is indicated that the pellet length is determined by the temperature gradient along the barrel right outside the freezing cell. Velocities of around 1000 m/s with a scatter of +- 2% are obtained with a propellant gas pressure of 40 bar

Importance of the cyanobacterial Gun4 protein for chlorophyll metabolism and assembly of photosynthetic complexes

Czech Academy of Sciences Publication Activity Database

Sobotka, Roman; Dühring, U.; Komenda, Josef; Peter, E.; Gardian, Zdenko; Tichý, Martin; Grimm, D.; Wilde, A.

2008-01-01

Roč. 283, č. 38 (2008), s. 25794-25802 ISSN 0021-9258 R&D Projects: GA AV ČR IAA500200713 Grant - others:DE(DE) SFB429; DE(DE) TPA8 Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50510513 Keywords : gun4 protein * chlorophyll metabolism * photosystem II Subject RIV: EE - Microbiology, Virology Impact factor: 5.520, year: 2008

The case for moderate gun control.

Science.gov (United States)

DeGrazia, David

2014-03-01

In addressing the shape of appropriate gun policy, this essay assumes for the sake of discussion that there is a legal and moral right to private gun ownership. My thesis is that, against the background of this right, the most defensible policy approach in the United States would feature moderate gun control. The first section summarizes the American gun control status quo and characterizes what I call "moderate gun control." The next section states and rebuts six leading arguments against this general approach to gun policy. The section that follows presents a positive case for moderate gun control that emphasizes safety in the home and society as well as rights whose enforcement entails some limits or qualifications on the right to bear arms. A final section shows how the recommended gun regulations address legitimate purposes, rather than imposing arbitrary restrictions on gun rights, and offers concluding reflections.

Photocathode operation of a thermionic RF gun

International Nuclear Information System (INIS)

Thorin, S.; Cutic, N.; Lindau, F.; Werin, S.; Curbis, F.

2009-01-01

The thermionic RF gun using a BaO cathode at the MAX-lab linac injector has been successfully commissioned for additional operation as a photocathode gun. By retaining the BaO cathode, lowering the temperature below thermal emission and illuminating it with a UV (263 nm) 9 ps laser pulse a reduced emittance and enhanced emission control has been achieved. Measurements show a normalised emittance of 5.5 mm mrad at 200 pC charge and a maximum quantum efficiency of 1.1x10 -4 . The gun is now routinely switched between storage ring injections in thermionic mode and providing a beam for the MAX-lab test FEL in photocathode mode.

American State Gun Law Strength and State Resident Differences in Neuroticism Levels

Directory of Open Access Journals (Sweden)

Stewart J. H. McCann

2016-04-01

Full Text Available Relations between state gun law strength and state-aggregated levels of Republican leaning, gun ownership, and resident Big Five neuroticism (based on 619,397 residents nationally were determined in a state-level analysis of the 50 American states using multiple regression strategies with state socioeconomic status, white population percent, and urban population percent statistically controlled. In a standard hierarchical model with state gun law strength as the criterion, the three demographic variables accounted for 44.4% of the variance and the Big Five accounted for another 21.9%. When the Big Five entered stepwise after the demographics, neuroticism was the sole significant personality predictor, accounting for another 13.4% of the variance. Greater state gun law strength was associated with higher state resident neuroticism. Further hierarchical regression analyses showed that state Republican leaning and gun ownership could account separately and jointly for significant variance in state gun law strength but not with state resident neuroticism controlled.

Perancangan Sistem Kontrol PID Untuk Pengendali Sumbu Elevasi Gun Pada Turret-Gun Kaliber 20 Milimeter

Directory of Open Access Journals (Sweden)

Dimas Kunto Ariwibowo

2017-01-01

Full Text Available Pertahanan negara pada hakikatnya adalah segala upaya pertahanan yang bersifat semesta yang didasarkan pada kesadaran atas hak dan kewajiban warga negara serta keyakinan pada kekuatan sendiri dengan tujuan untuk menjaga dan melindungi kedaulatan negara, keutuhan wilayah NKRI dan keselamatan segenap bangsa. Salah satu alat pendukung pertahanan yaitu senjata laras panjang, Turret-Gun.  Adapun langkah-langkah yang dilakukan dalam merancang pengendali PID Turret-Gun kaliber 20mm ini diawali dengan studi literatur serta studi lapangan mengenai mekanisme dan parameter-parameter yang terdapat pada Turret-Gun pada sumbu elevasi. Setelah itu dilakukan perancangan transmisi dan sistem kontrol Turret-Gun untuk dievaluasi grafik responnya yang akan digunakan sebagai acuan untuk merancang pengendali PID yang sesuai. Selanjutnya pengendali PID yang telah dirancang lalu disimulasikan, sehingga menghasilkan grafik respon yang sesuai dengan kriteria yang dibutuhkan. Hasil yang telah didapatkan dari penelitian ini adalah konstanta PID yang direkomendasikan untuk , , dan secara berturut-turut adalah sebesar 23061.024, 37820.07 dan 3515.4 yang menghasilkan transient response dengan nilai overshoot sebesar 19.9 % , steady state error sebesar 0 % serta settling time sebesar 0.935 detik. Hasil analisa kestabilan untuk sistem kontrol dengan konstanta PID tersebut menunjukkan bahwa sistem kontrol telah stabil, baik menggunakan metode Root Locus maupun metode Routh-Hurwitz.

Access to a Loaded Gun Without Adult Permission and School-Based Bullying.

Science.gov (United States)

Simckes, Maayan S; Simonetti, Joseph A; Moreno, Megan A; Rivara, Frederick P; Oudekerk, Barbara A; Rowhani-Rahbar, Ali

2017-09-01

Gun access and bullying are risk factors for sustaining or perpetrating violence among adolescents. Our knowledge of gun access among bullied students is limited. We used data on students, aged 12-18 years, from the 2011 and 2013 School Crime Supplement to the National Crime Victimization Survey to assess the association between self-reported bullying victimization (traditional and cyber) and access to a loaded gun without adult permission. Prevalence ratios (PRs) and confidence intervals (CIs) were obtained from multivariable Poisson regression using the Taylor series after controlling for student age, sex, family income, public/private school, and race. Of 10,704 participants, 4.2% (95% CI: 3.8%-4.6%) reported gun access. Compared with nonbullied students, those who reported traditional bullying (PR = 2.2; 95% CI: 1.7-2.4), cyberbullying (PR = 2.8; 95% CI: 1.6-4.9), and both (PR = 5.9; 95% CI: 4.6-7.7) were more likely to also report gun access. Adolescents who experience bullying, particularly those who report both traditional bullying and cyberbullying, are more likely to report access to a loaded gun without adult permission. These findings highlight the importance of developing interventions focused on these modifiable risk factors for preventing self-directed or interpersonal violence among youth. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

ORELA electron guns

International Nuclear Information System (INIS)

Christian, O.W.; Lewis, T.A.

1981-09-01

The most recent information concerning the production and performance of ORELA electron guns is presented. Included are descriptions of procedures for gun fabrication, cathode conditioning and high voltage processing. Highlights of the performance characteristics are also included

RF Design of the LCLS Gun

International Nuclear Information System (INIS)

Limborg-Deprey, C.

2010-01-01

Final dimensions for the LCLS RF gun are described. This gun, referred to as the LCLS gun, is a modified version of the UCLA/BNL/SLAC 1.6 cell S-Band RF gun (1), referred to as the prototype gun. The changes include a larger mode separation (15 MHz for the LCLS gun vs. 3.5 MHz for the prototype gun), a larger radius at the iris between the 2 cells, a reduced surface field on the curvature of the iris between the two cells, Z power coupling, increased cooling channels for operation at 120 Hz, dual rf feed, deformation tuning of the full cell, and field probes in both cells. Temporal shaping of the klystron pulse, to reduce the average power dissipated in the gun, has also been adopted. By increasing the mode separation, the amplitude of the 0-mode electric field on the cathode decreases from 10% of the peak on axis field for the prototype gun to less than 3% for the LCLS gun for the steady state fields. Beam performance is improved as shown by the PARMELA simulations. The gun should be designed to accept a future load lock system. Modifications follow the recommendations of our RF review committee (2). Files and reference documents are compiled in Section IV.

Gene gun bombardment-mediated expression and translocation of EGFP-tagged GLUT4 in skeletal muscle fibres in vivo

DEFF Research Database (Denmark)

Lauritzen, Hans P M M; Reynet, Christine; Schjerling, Peter

2002-01-01

the enhanced green fluorescent protein (EGFP) labelling technique with physical transfection methods in vivo: intramuscular plasmid injection or gene gun bombardment. During optimisation experiments with plasmid coding for the EGFP reporter alone EGFP-positive muscle fibres were counted after collagenase...... treatment of in vivo transfected flexor digitorum brevis (FDB) muscles. In contrast to gene gun bombardment, intramuscular injection produced EGFP expression in only a few fibres. Regardless of the transfection technique, EGFP expression was higher in muscles from 2-week-old rats than in those from 6-week......Cellular protein trafficking has been studied to date only in vitro or with techniques that are invasive and have a low time resolution. To establish a gentle method for analysis of glucose transporter-4 (GLUT4) trafficking in vivo in fully differentiated rat skeletal muscle fibres we combined...

Practical XHV electron gun

International Nuclear Information System (INIS)

Urata, Tomohiro; Ishikawa, Tsuyoshi; Cho, Boklae; Oshima, Chuhei

2008-01-01

We have developed practical XHV chambers of a electron gun, of which the operating pressures are 1x10 -9 Pa in a stainless-steel one and 4x10 -9 Pa in a permalloy one. By mounting a noble single-atom electron source with high brightness and high spatial coherence on the electron gun including electron optics, we demonstrated highly collimated electron-beam emission: ∼80% of the total emission current entered the electron optics. This ratio was two or three orders of magnitude higher than those of the conventional electron sources. In XHV, in addition, we confirmed stable electron emission up to 20 nA, which results in the specimen current high enough for scanning electron microscopes. (author)

Gun Violence Following Inpatient Psychiatric Treatment: Offense Characteristics, Sources of Guns, and Number of Victims.

Science.gov (United States)

Kivisto, Aaron J

2017-10-01

This study presents data on the relative contribution to gun violence by people with a history of inpatient psychiatric treatment and on federal efforts to deter presumptively dangerous persons from obtaining firearms, information useful for analyzing the potential public health benefits of gun policies targeting people with serious mental illness. The study also estimates the reduction in gun violence victims that would be expected if individuals with a previous psychiatric hospitalization were prohibited from purchasing firearms. Data from 838 violent gun offenders from a nationally representative sample of state prison inmates were analyzed. Those with and without a history of psychiatric hospitalization were compared on a range of offense characteristics, including relationship to the victim, number of victims, location of the offense, and source of firearms. Inmates with a history of hospitalization constituted 12% of all violent gun offenders and accounted for 13% of the sample's victims. They were less likely than those without a previous hospitalization to victimize strangers (odds ratio=.52) and were no more likely to commit gun violence in public or to have multiple victims. Among those with previous hospitalizations, 78% obtained guns from sources not subject to federal background checks. Of the total 1,041 victims of gun violence, only 3% were victimized by participants with a history of hospitalization who obtained guns from currently regulated sources. Prohibiting all individuals with a history of psychiatric hospitalization from purchasing firearms, absent expanded background checks, was estimated to reduce the number of gun violence victims by only 3%.

Unbalanced field RF electron gun

Science.gov (United States)

Hofler, Alicia

2013-11-12

A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam.

From gun politics to self-defense politics: a feminist critique of the great gun debate.

Science.gov (United States)

Carlson, Jennifer D

2014-03-01

This article calls attention to a problematic binary produced by public debates surrounding gun rights and gun control-namely, that women must choose armed self-protection or no self-protection at all. I argue that both anti- and pro-gun discourses, drawing on and reproducing race and class privileges, use assumptions about women's physical inferiority to further their agendas. I highlight how both sides have used guns as the proxy for self-defense and conclude by calling for a shift in public discourse to focus on the broader question of the right to self-defense rather than the narrower question of gun rights.

Design and operation of a coaxial plasma gun at magnetic fields exceeding 0.5 megagauss

International Nuclear Information System (INIS)

Conte, D.; Bird, G.; Boyer, C.; Davis, J.; Seiler, S.; Turchi, P.

1981-01-01

The use of coaxial plasma guns to accumulate and concentrate electromagnetic and kinetic energy at high currents and power flux levels has been examined experimentally. For these studies, apparatus was designed to employ magnetic fields approaching 1MG, using the AFWL Shiva capacitor bank as the current source (1.9 MJ, 120 KV). The design divided the system into two major component regions: 1) a reusable cylindrical transition to the Shiva bank, an 2) disposable guns and feed plates

A high-brightness thermionic microwave electron gun

Energy Technology Data Exchange (ETDEWEB)

Borland, Michael [Stanford Univ., CA (United States)

1991-02-01

In a collaborative effort by SSRL, AET Associates, and Varian Associates, a high-brightness microwave electron gun using a thermionic cathode has been designed, built, tested, and installed for use with the SSRL 150 MeV linear accelerator. This thesis discusses the physics behind the design and operation of the gun and associated systems, presenting predictions and experimental tests of the gun`s performance. The microwave gun concept is of increasing interest due to its promise of providing higher-current, lower-emittance electron beams than possible from conventional, DC gun technology. In a DC guns, accelerating gradients are less than 8 MV/m, while those in a microwave gun can exceed 100 MV/m, providing much more rapid initial acceleration, thereby reducing the deleterious effects of space-charge. Microwave guns produce higher momentum beams than DC guns, thus lessening space-charge effects during subsequent beam transport. Typical DC guns produce kinetic energies of 80--400 KeV, compared to 2--3 MeV for the SSRL microwave gun. ``State-of-the-art`` microwave gun designs employ laser-driven photocathodes, providing excellent performance but with greater complexity and monetary costs. A thermionic microwave gun with a magnetic bunching system is comparable in cost and complexity to a conventional system, but provides performance that is orders of magnitude better. Simulations of the SSRL microwave gun predict a normalized RMS emittance at the gun exist of < 10 π • m_ec • μm for a beam consisting of approximately 50% of the particles emitted from the gun, and having a momentum spread ±10%. These emittances are for up to 5 x 10⁹e^- per bunch. Chromatic aberrations in the transport line between the gun and linear accelerator increase this to typically < 30 π • m_e • μm.

Cofactor and CO2 donor regulation involved in reductive routes for polymalic acid production by Aureobasidium pullulans CCTCC M2012223.

Science.gov (United States)

Zou, Xiang; Tu, Guangwei; Zan, Zhanquan

2014-10-01

Polymalic acid (PMA) is a water-soluble polyester with many attractive properties for biomedical application. Its monomer L-malic acid is widely used in the food industry and also a potential C4 platform chemical. Cofactor and CO2 donor involved in the reductive routes were investigated for PMA production by Aureobasidium pullulans. Biotin as the key cofactor of pyruvate carboxylase was favor for the PMA biosynthesis. Na2CO3 as CO2 donor can obviously improved PMA titer when compared with no CO2 supplier NaOH, and also exhibit more advantages than the other donor CaCO3 because of its water-soluble characteristic. A combinational process with addition of biotin 70 mg/L and Na2CO3 as the CO2 donor was scaled-up in 50 L fermentor, achieving the high product 34.3 g/L of PMA and productivity of 0.41 g/L h. This process provides an efficient and economical way for PMA and malic acid production, and is promising for industrial application.

A high-brightness thermionic microwave electron gun

International Nuclear Information System (INIS)

Borland, M.

1991-02-01

In a collaborative effort by SSRL, AET Associates, and Varian Associates, a high-brightness microwave electron gun using a thermionic cathode has been designed, built, tested, and installed for use with the SSRL 150 MeV linear accelerator. This thesis discusses the physics behind the design and operation of the gun and associated systems, presenting predictions and experimental tests of the gun's performance. The microwave gun concept is of increasing interest due to its promise of providing higher-current, lower-emittance electron beams than possible from conventional, DC gun technology. In a DC guns, accelerating gradients are less than 8 MV/m, while those in a microwave gun can exceed 100 MV/m, providing much more rapid initial acceleration, thereby reducing the deleterious effects of space-charge. Microwave guns produce higher momentum beams than DC guns, thus lessening space-charge effects during subsequent beam transport. Typical DC guns produce kinetic energies of 80--400 KeV, compared to 2--3 MeV for the SSRL microwave gun. ''State-of-the-art'' microwave gun designs employ laser-driven photocathodes, providing excellent performance but with greater complexity and monetary costs. A thermionic microwave gun with a magnetic bunching system is comparable in cost and complexity to a conventional system, but provides performance that is orders of magnitude better. Simulations of the SSRL microwave gun predict a normalized RMS emittance at the gun exist of e c · μm for a beam consisting of approximately 50% of the particles emitted from the gun, and having a momentum spread ±10%. These emittances are for up to 5 x 10 9 e - per bunch. Chromatic aberrations in the transport line between the gun and linear accelerator increase this to typically e · μm

Nuclear Receptor Cofactors in PPARγ-Mediated Adipogenesis and Adipocyte Energy Metabolism

Directory of Open Access Journals (Sweden)

Emily Powell

2007-01-01

Full Text Available Transcriptional cofactors are integral to the proper function and regulation of nuclear receptors. Members of the peroxisome proliferator-activated receptor (PPAR family of nuclear receptors are involved in the regulation of lipid and carbohydrate metabolism. They modulate gene transcription in response to a wide variety of ligands, a process that is mediated by transcriptional coactivators and corepressors. The mechanisms by which these cofactors mediate transcriptional regulation of nuclear receptor function are still being elucidated. The rapidly increasing array of cofactors has brought into focus the need for a clear understanding of how these cofactors interact in ligand- and cell-specific manners. This review highlights the differential effects of the assorted cofactors regulating the transcriptional action of PPARγ and summarizes the recent advances in understanding the physiological functions of corepressors and coactivators.

The glmS ribozyme cofactor is a general acid-base catalyst.

Science.gov (United States)

Viladoms, Júlia; Fedor, Martha J

2012-11-21

The glmS ribozyme is the first natural self-cleaving ribozyme known to require a cofactor. The d-glucosamine-6-phosphate (GlcN6P) cofactor has been proposed to serve as a general acid, but its role in the catalytic mechanism has not been established conclusively. We surveyed GlcN6P-like molecules for their ability to support self-cleavage of the glmS ribozyme and found a strong correlation between the pH dependence of the cleavage reaction and the intrinsic acidity of the cofactors. For cofactors with low binding affinities, the contribution to rate enhancement was proportional to their intrinsic acidity. This linear free-energy relationship between cofactor efficiency and acid dissociation constants is consistent with a mechanism in which the cofactors participate directly in the reaction as general acid-base catalysts. A high value for the Brønsted coefficient (β ~ 0.7) indicates that a significant amount of proton transfer has already occurred in the transition state. The glmS ribozyme is the first self-cleaving RNA to use an exogenous acid-base catalyst.

Racism, Gun Ownership and Gun Control: Biased Attitudes in US Whites May Influence Policy Decisions

OpenAIRE

O?Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

2013-01-01

OBJECTIVE: Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. METHOD: The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US wh...

Lanthanide Cofactors for Triphosphorylation Ribozymes

Science.gov (United States)

Sweeney, K. J.; Müller, U. F.

2017-07-01

RNA world organisms could have used trimetaphosphate as energy source for thermodynamically unfavorable RNA polymerization. Using in vitro selection we show here that Lanthanides can serve as cofactors for ribozyme-catalyzed RNA triphosphorylation.

CID thermionic gun system

International Nuclear Information System (INIS)

Koontz, R.F.

1981-10-01

A new high-current thermionic gun has been installed on the CID injector at SLAC and brought into operation. The gun and pulser system generate three nanosecond pulses of about six amps peak which, when bunched in the subharmonic buncher system, produce in excess of 10 11 electrons in a single S-band accelerated bunch. Preliminary operation of the gun is described, and details of the avalanche cathode drive pulser are presented

CID thermionic gun system

International Nuclear Information System (INIS)

Koontz, R.F.

1982-01-01

A new high-current thermionic gun has been installed on the CID injector at SLAC and brought into operation. The gun and pulser system generate three nanosecond pulses of about six amps peak which, when bunched in the subharmonic buncher system, produce in excess of 10 11 electrons in a single S-band accelerated bunch. Preliminary operation of the gun is described, and details of the avalanche cathode drive pulser are presented

X-Band RF Gun Development

International Nuclear Information System (INIS)

Vlieks, A.E.

2012-01-01

In support of the MEGa-ray program at LLNL and the High Gradient research program at SLAC, a new X-band multi-cell RF gun is being developed. This gun, similar to earlier guns developed at SLAC for Compton X-ray source program, will be a standing wave structure made of 5.5 cells operating in the pi mode with copper cathode. This gun was designed following criteria used to build SLAC X-band high gradient accelerating structures. It is anticipated that this gun will operate with surface electric fields on the cathode of 200 MeV/m with low breakdown rate. RF will be coupled into the structure through a final cell with symmetric duel feeds and with a shape optimized to minimize quadrupole field components. In addition, geometry changes to the original gun, operated with Compton X-ray source, will include a wider RF mode separation, reduced surface electric and magnetic fields.

Large-area thin self-supporting carbon foils with MgO coatings

Science.gov (United States)

Stolarz, Anna; Maier-Komor, Peter

2002-03-01

Large area self-supporting carbon foils in the thickness of range of 8-22 μg/cm 2, coated with approximately 4 μg/cm 2 MgO have been prepared by e-gun evaporation. They were mounted on frames with apertures of 130 cm 2. Problems related to the parting agent preparation, floating procedure, and mounting onto frames are discussed. Special precautions necessary to avoid damage during foil drying, storage and transportation are suggested.

Preventing gun injuries in children.

Science.gov (United States)

Crossen, Eric J; Lewis, Brenna; Hoffman, Benjamin D

2015-02-01

Firearms are involved in the injury and death of a large number of children each year from both intentional and unintentional causes. Gun ownership in homes with children is common, and pediatricians should incorporate evidence-based means to discuss firearms and protect children from gun-related injuries and violence. Safe storage of guns, including unloaded guns locked and stored separately from ammunition, can decrease risks to children, and effective tools are available that pediatricians can use in clinical settings to help decrease children's access to firearms. Furthermore, several community-based interventions led by pediatricians have effectively reduced firearm-related injury risks to children. Educational programs that focus on children's behavior around guns have not proven effective. © American Academy of Pediatrics, 2015. All rights reserved.

Gun violence trends in movies.

Science.gov (United States)

Bushman, Brad J; Jamieson, Patrick E; Weitz, Ilana; Romer, Daniel

2013-12-01

Many scientific studies have shown that the mere presence of guns can increase aggression, an effect dubbed the "weapons effect." The current research examines a potential source of the weapons effect: guns depicted in top-selling films. Trained coders identified the presence of violence in each 5-minute film segment for one-half of the top 30 films since 1950 and the presence of guns in violent segments since 1985, the first full year the PG-13 rating (age 13+) was used. PG-13-rated films are among the top-selling films and are especially attractive to youth. Results found that violence in films has more than doubled since 1950, and gun violence in PG-13-rated films has more than tripled since 1985. When the PG-13 rating was introduced, these films contained about as much gun violence as G (general audiences) and PG (parental guidance suggested for young children) films. Since 2009, PG-13-rated films have contained as much or more violence as R-rated films (age 17+) films. Even if youth do not use guns, these findings suggest that they are exposed to increasing gun violence in top-selling films. By including guns in violent scenes, film producers may be strengthening the weapons effect and providing youth with scripts for using guns. These findings are concerning because many scientific studies have shown that violent films can increase aggression. Violent films are also now easily accessible to youth (e.g., on the Internet and cable). This research suggests that the presence of weapons in films might amplify the effects of violent films on aggression.

Results from operation of metal melting electron gun

International Nuclear Information System (INIS)

Balloni, A.J.; Paes, A.C.J.; Miliano, A.C.

1988-09-01

The first results obtained during the operation of metal melting electron gun, of power 30Kw and current 1,2A, developed at IEAv, are presented. Details on operation of beam transport system (composed by magnetic lens and prism), from generation to fusion chamber and cathode construction. Into the fusion chamber the presssure can reach 10 -4 Pa, seeing that the gun test consisted in fusion for purification of approximatelly 1Kg titanium bar. The input average power was 12Kw, and the fusion remainded during 16 minutes. The calculated thermal efficiency was of the order of 10% consistent with the results found out in literature, for this type of gun. (M.C.K.) [pt

Supply system with microprocessor control for electron gun

International Nuclear Information System (INIS)

Duplin, N.I.; Sergeev, N.N.

1988-01-01

Precision supply system for electron gun used in Auger-spectrometer is described. The supply system consists of control and high-voltage parts, made as separate units. Supply high-voltage unit includes system supply module, filament module to supply electron gun cathode and 6 high-volt modules to supply accelerating, modulating and three focusing electrodes of the gun. High-voltage modules have the following characteristics: U-(100-1000)V output voltage, 5x10 -5 U stability, 10 -5 xU pulsation amplitude, J-(0-5)A filament current change range at 10 -4 xJ stability. Control unit including microprocessor, timer and storage devices forms control voltage for all modules and regulates voltage and current of filament at electrodes

Low emittance thermionic electron guns

International Nuclear Information System (INIS)

Herrmannsfeldt, W.B.

1989-01-01

The author discusses self-field effects and external field effects for electron guns. He also discusses designs of electron guns and their uses in electron cooling systems and as an injector for electrostatic free electron lasers. He closes by looking at electron guns for linear accelerators. 20 references, 3 figures

A flow cryostat for cooling of eight independent pipe guns

DEFF Research Database (Denmark)

Sørensen, H.; Hansen, J.E.; Sass, B.

1991-01-01

A flow cryostat allowing independent cooling of eight pipe guns in a multishot deuterium pellet injector is described. The pipe guns are placed symmetrically around the flow cryostat and with a liquid helium consumption of 4-5 l/h the cooling is sufficient for simultaneous formation of eight...

The HART I augmented electric gun facility

International Nuclear Information System (INIS)

Fikse, D.A.; Ciesar, J.A.; Wehrli, H.A.; Rimersma, H.; Docherty, E.F.; Pipich, C.W.

1991-01-01

This paper reports on an augmented electric gun system that has been commissioned. This system, called HART I (Hypervelocity Augmented Railgun Test), is built around a double augmented rail arrangement with a 1.27-cm square bore. It is powered by the SUVAC II 5.6-MJ distributed capacitor power supply. This arrangement allows operation in a simple, series augmented, or transaugmented gun system configuration. The objective of this facility is to perform materials research augmentation studies, and armature development in the 10-km/s regime. Armature masses of 2 to 4 g will be accelerated in a 4-m long barrel. Baseline bore materials will begin with conventional G9/GlidCop systems and then move into pyrolytic boron nitride/refractory materials. Hybrids, plasma, and ablation stabilized armature systems are planned. The gun system is instrumented with plasma and rail B probes for inbore velocity measurements. In addition, breech and muzzle voltages, currents, and external velocities are measured. The HART I system is currently performing hypervelocity experiments to verify the augmentation models

Guns at College.

Science.gov (United States)

Miller, Matthew; Hemenway, David; Wechsler, Henry

1999-01-01

Surveyed undergraduate students nationwide concerning firearm possession. About 3.5% possessed working firearms. Students with guns were more likely to be male, White, or Native American; binge drink; live off-campus; and live with a spouse or significant other. Students with guns were more likely to engage in activities that put themselves and…

Relationship between licensing, registration, and other gun sales laws and the source state of crime guns.

Science.gov (United States)

Webster, D W; Vernick, J S; Hepburn, L M

2001-09-01

To determine the association between licensing and registration of firearm sales and an indicator of gun availability to criminals. Tracing data on all crime guns recovered in 25 cities in the United States were used to estimate the relationship between state gun law categories and the proportion of crime guns first sold by in-state gun dealers. In cities located in states with both mandatory registration and licensing systems (five cities), a mean of 33.7% of crime guns were first sold by in-state gun dealers, compared with 72.7% in cities that had either registration or licensing but not both (seven cities), and 84.2% in cities without registration or licensing (13 cites). Little of the difference between cities with both licensing and registration and cities with neither licensing nor registration was explained by potential confounders. The share of the population near a city that resides in a neighboring state without licensing or registration laws was negatively associated with the outcome. States with registration and licensing systems appear to do a better job than other states of keeping guns initially sold within the state from being recovered in crimes. Proximity to states without these laws, however, may limit their impact.

Electrical properties of a co-axial plasma gun

International Nuclear Information System (INIS)

Allam, T.M.Y.

1997-01-01

The main interest of this work is to study the power discharge of capacitor bank through a coaxial electrodes system. Such arrangement is called the coaxial gun or coaxial accelerator. It is used in jet propulsion and in triggering of discharge in turbo engines or in plasma combustion arrangement. The main goal is to find out the efficiency of the system in both cases. coaxial plasma gun system has been constructed for this course of study. The plasma gun system consists of the plasma gun tube and the discharge chamber, the capacitor bank, the triggering system the vacuum system, the power supply, and safety and dumping system. Simple and efficient diagnostic techniques were used to measure the different parameters concerning the coaxial discharge system such as the Rogowski loop, the voltage divider, the magnetic probes, the double electric probe. Results were obtained using argon gas with an operating pressure ranging from 0.1 torr to 1 torr. The peak discharge current in the first half cycle was 44 K A with rise time of 6.25 μs for a bank charging voltage of 10 kv and gas pressure of 0.9 torr. 4-26 figs., 4-8 tabs., 33 refs

Pharmacokinetic characterization of three novel 4-mg nicotine lozenges
.

Science.gov (United States)

Sukhija, Manpreet; Srivastava, Reena; Kaushik, Aditya

2018-03-01

Nicotine replacement therapy (NRT) increases the probability of smoking cessation. This study was conducted to determine if three prototype 4-mg nicotine lozenges produced locally in India were bioequivalent to a globally marketed reference product, Nicorette® 4-mg nicotine lozenge. Healthy adult smokers (N = 39) were treated with three prototype 4-mg nicotine lozenges in comparison with a reference 4-mg lozenge in this single-center, randomized, open-label, single-dose, 4-way crossover study. Pharmacokinetic sampling was obtained to test for bioequivalence using maximal plasma concentration (Cmax) and extent of absorption (AUC0-t). Secondarily, AUC;0-∞, time to maximal plasma concentration (tmax), half-life (T1/2), elimination rate constant (Kel), and safety of the prototype lozenges versus the reference lozenge were compared. Each prototype 4-mg nicotine lozenge was found to be bioequivalent to the reference 4-mg nicotine lozenge based on the ratio of geometric means and 90% confidence intervals for Cmax, AUC0-t, and AUC;0-∞. Although tmax; was significantly longer for prototype III, all four lozenges achieved maximum plasma nicotine concentrations at a median of 1.5 hours. The safety profiles of the three prototype 4-mg lozenges did not differ from that of the 4-mg reference product. Each prototype 4-mg nicotine lozenge was bioequivalent to the reference 4-mg nicotine lozenge and was well tolerated. Furthermore, as these bioequivalent prototypes differed in in-vitro dissolution profiles, these data suggest that performance from the in -vitro method deployed is not a firm predictor of pharmacokinetic behavior.
.

Remaining challenges in cellular flavin cofactor homeostasis and flavoprotein biogenesis

Science.gov (United States)

Giancaspero, Teresa Anna; Colella, Matilde; Brizio, Carmen; Difonzo, Graziana; Fiorino, Giuseppina Maria; Leone, Piero; Brandsch, Roderich; Bonomi, Francesco; Iametti, Stefania; Barile, Maria

2015-04-01

The primary role of the water-soluble vitamin B2 (riboflavin) in cell biology is connected with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases, oxidases and reductases involved in energetic metabolism, epigenetics, protein folding, as well as in a number of diverse regulatory processes. The problem of localisation of flavin cofactor synthesis events and in particular of the FAD synthase (EC 2.7.7.2) in HepG2 cells is addressed here by confocal microscopy in the frame of its relationships with kinetics of FAD synthesis and delivery to client apo-flavoproteins. FAD synthesis catalysed by recombinant isoform 2 of FADS occurs via an ordered bi-bi mechanism in which ATP binds prior to FMN, and pyrophosphate is released before FAD. Spectrophotometric continuous assays of the reconstitution rate of apo-D-aminoacid oxidase with its cofactor, allowed us to propose that besides its FAD synthesising activity, hFADS is able to operate as a FAD "chaperone". The physical interaction between FAD forming enzyme and its clients was further confirmed by dot blot and immunoprecipitation experiments carried out testing as a client either a nuclear or a mitochondrial enzyme that is lysine specific demethylase 1 (LSD1, EC 1.-.-.-) and dimethylglycine dehydrogenase (Me2GlyDH, EC 1.5.8.4), respectively which carry out similar reactions of oxidative demethylation, assisted by tetrahydrofolate used to form 5,10-methylene-tetrahydrofolate. A direct transfer of the cofactor from hFADS2 to apo-dimethyl glycine dehydrogenase was also demonstrated. Thus, FAD synthesis and delivery to these enzymes are crucial processes for bioenergetics and nutri-epigenetics of liver cells.

Results of the AFWL deflagration gun experiments

International Nuclear Information System (INIS)

Hackett, K.E.; Baker, W.L.; Beason, J.D.

1987-01-01

The snowplow and deflagration modes of coaxial plasma gun operation have been experimentally investigated and computationally simulated at the Air Force Weapons Laboratory. The snowplow mode occurs when the gun is prefilled to a uniform gas density. The initial breakdown forms near the insulator at the gun breech. It heats the gas and creates a shock wave that travels down the gun, ionizing gas and producing a thin current sheath that travels just behind the shock front. The shock front piles up the gas in front of itself as it moves down the gun - hence the name ''snowplow''. Deflagration occurs when gas is injected into an evacuated gun so that the initial breakdown forms as the gas fills the gun. The ionized gas is accelerated into the vacuum region carrying current and magnetic field with it. A quasi-stationary diffuse discharge develops. Gas still entering the gun is processed through the deflagrating discharge and accelerated out the gun muzzle

RF guns: a review

International Nuclear Information System (INIS)

Travier, C.

1990-06-01

Free Electron Lasers and future linear colliders require very bright electron beams. Conventional injectors made of DC guns and RF bunchers have intrinsic limitations. The recently proposed RF guns have already proven their capability to produce bright beams. The necessary effort to improve further these performances and to gain reliability is now undertaken by many laboratories. More than twenty RF gun projects both thermionic and laser-driven are reviewed. Their specific characteristics are outlined and their nominal performances are given

THE IMPROVEMENT AND APPLICATION OF EI-GUN (ELECTRICAL INSEMINATION GUN FOR ARTIFICIAL INSEMINATION (AI USING GOAT FRESH SEMEN

Directory of Open Access Journals (Sweden)

Mirsa Ita Dewi

2017-03-01

Full Text Available Electrical Insemination Gun (EI-GUN was a tool for Artificial Insemination (AI using fresh semen with an electric control system. The research objective was to produced EI-GUN for AI using fresh semen on small ruminants (goat. The research was conducted from March to June 2015. The process of EI-GUN creation implemented in Design and Prototype Laboratory and Aero Modeling Research Laboratory at Engineering Faculty, University of Brawijaya (UB. Testing tools EI-GUN on goat was conducted in the Sumber Sekar Laboratory, Animal Husbandry Faculty, UB.  The methods of research were literature study, tool specification determination, designing EI-GUN, running test, semen evaluation passed EI-GUN and application on Goat. EI-GUN has seven important parts, which supports each other in this operating system. Those parts consist of stylet, servo, system controlled, insemination pump, connecting rod, battery, and holder. EI-GUN work system sucked the semen into insemination pump as much as 5 ml, and release the semen 0.25 ml appropriate standard of AI. It was applicable for 20 times AI. The results showed that the cell motility of spermatozoa ≥ 70% were still in ranging of Indonesian National Standard (SNI.   Keywords: artificial insemination, EI-GUN, fresh semen.

Understanding and Predicting Gun Barrel Erosion

National Research Council Canada - National Science Library

Johnston, Ian A

2005-01-01

The Australian Defence Force will soon have to contend with gun barrel erosion issues arising from the use of new low-vulnerability gun propellants, the acquisition of new ammunition and gun systems...

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases.

Science.gov (United States)

Cahn, Jackson K B; Werlang, Caroline A; Baumschlager, Armin; Brinkmann-Chen, Sabine; Mayo, Stephen L; Arnold, Frances H

2017-02-17

The ability to control enzymatic nicotinamide cofactor utilization is critical for engineering efficient metabolic pathways. However, the complex interactions that determine cofactor-binding preference render this engineering particularly challenging. Physics-based models have been insufficiently accurate and blind directed evolution methods too inefficient to be widely adopted. Building on a comprehensive survey of previous studies and our own prior engineering successes, we present a structure-guided, semirational strategy for reversing enzymatic nicotinamide cofactor specificity. This heuristic-based approach leverages the diversity and sensitivity of catalytically productive cofactor binding geometries to limit the problem to an experimentally tractable scale. We demonstrate the efficacy of this strategy by inverting the cofactor specificity of four structurally diverse NADP-dependent enzymes: glyoxylate reductase, cinnamyl alcohol dehydrogenase, xylose reductase, and iron-containing alcohol dehydrogenase. The analytical components of this approach have been fully automated and are available in the form of an easy-to-use web tool: Cofactor Specificity Reversal-Structural Analysis and Library Design (CSR-SALAD).

Spectral diagnostic of plasma in the coaxial gun

International Nuclear Information System (INIS)

Bacilek, J.; Hruska, J.; Kubes, P.

1975-01-01

Plasma ejected from a coaxial plasma gun was investigated spectroscopically. The coaxial gun consisted of two copper coaxial electrodes 57 and 100 mm in diameter, the length of the central electrode being 67 mm. The gun was fed by a 11 μF capacitor bank of 16 kV operating voltage. Hydrogen, helium and air were used as working gases. The emission spectra were recorded with spectrograph ISP-51 and with a monochromator-photomultiplier system. The plasma density reached its maximum of 4x10 15 cm -3 with the ejecting voltage applied some 20 to 30 μs after the gas injection. At this moment also the spectral lines of electrode material were most intensive. The electron temperature calculated from the presence of spectral lines of OII, CII and NII was about 2 eV. The velocity of fast hydrogen ions was 4x10 7 cmsec -1 calculated from the Hsub(β) line. (J.U.)

Water guns affect abundance and behavior of bigheaded carp and native fish differently

Science.gov (United States)

Rivera, Jose; Glover, David C.; Kocovsky, Patrick; Garvey, James E.; Gaikowski, Mark; Jensen, Nathan R.; Adams, Ryan F.

2017-01-01

Water guns have shown the potential to repel nuisance aquatic organisms. This study examines the effects of exposure to a 1966.4 cm3 seismic water gun array (two guns) on the abundance and behavior of Bighead Carp Hypophthalmichthys nobilis, Silver Carp H. molitrix (collectively referred to as bigheaded carp) and native fishes (e.g., Smallmouth Buffalo Ictiobus bubalus). Water guns were deployed in a channel that connects the Illinois River to backwater quarry pits that contained a large transient population of bigheaded carp. To evaluate the effect of water guns, mobile side-looking split-beam hydroacoustic surveys were conducted before, during and between replicated water gun firing periods. Water guns did not affect abundance of bigheaded carp, but abundance of native fish detected during the firing treatment was 43 and 34% lower than the control and water guns off treatments, respectively. The proximity of bigheaded carp to the water gun array was similar between the water guns on and water guns off treatments. In contrast, the closest detected native fish were detected farther from the water guns during the water guns on treatment (mean ± SE, 32.38 ± 3.32 m) than during the water guns off treatment (15.04 ± 1.59 m). The water gun array had a greater impact on native fish species than on bigheaded carp. Caution should be taken to the extrapolation of these results to other fish species and to fish exposed to water guns in different environments (e.g., reduced shoreline interaction) or exposure to a larger array of water guns, or for use of water guns for purposes other than a barrier.

Water guns affect abundance and behavior of bigheaded carp and native fish differently

Science.gov (United States)

Rivera, Jose; Glover, David C.; Kocovsky, Patrick; Garvey, James E.; Gaikowski, Mark; Jensen, Nathan R.; Adams, Ryan F.

2018-01-01

Water guns have shown the potential to repel nuisance aquatic organisms. This study examines the effects of exposure to a 1966.4 cm3 seismic water gun array (two guns) on the abundance and behavior of Bighead Carp Hypophthalmichthys nobilis, Silver Carp H. molitrix (collectively referred to as bigheaded carp) and native fishes (e.g., Smallmouth Buffalo Ictiobus bubalus). Water guns were deployed in a channel that connects the Illinois River to backwater quarry pits that contained a large transient population of bigheaded carp. To evaluate the effect of water guns, mobile side-looking split-beam hydroacoustic surveys were conducted before, during and between replicated water gun firing periods. Water guns did not affect abundance of bigheaded carp, but abundance of native fish detected during the firing treatment was 43 and 34% lower than the control and water guns off treatments, respectively. The proximity of bigheaded carp to the water gun array was similar between the water guns on and water guns off treatments. In contrast, the closest detected native fish were detected farther from the water guns during the water guns on treatment (mean ± SE, 32.38 ± 3.32 m) than during the water guns off treatment (15.04 ± 1.59 m). The water gun array had a greater impact on native fish species than on bigheaded carp. Caution should be taken to the extrapolation of these results to other fish species and to fish exposed to water guns in different environments (e.g., reduced shoreline interaction) or exposure to a larger array of water guns, or for use of water guns for purposes other than a barrier.

Electron gun for SSRF

International Nuclear Information System (INIS)

Sheng Shugang; Lin Guoqiang; Gu Qiang; Li Deming

2003-01-01

A 100 kV triode-electron-gun has been designed and manufactured for the Linac of Shanghai Synchrotron Radiation Facility (SSRF). In this paper the performance of the gun and some key components are described

Automatic targeting of plasma spray gun

Science.gov (United States)

Abbatiello, Leonard A.; Neal, Richard E.

1978-01-01

A means for monitoring the material portion in the flame of a plasma spray gun during spraying operations is provided. A collimated detector, sensitive to certain wavelengths of light emission, is used to locate the centroid of the material with each pass of the gun. The response from the detector is then relayed to the gun controller to be used to automatically realign the gun.

Automatic targeting of plasma spray gun

International Nuclear Information System (INIS)

Abbatiello, L.A.; Neal, R.E.

1978-01-01

A means for monitoring the material portion in the flame of a plasma spray gun during spraying operations is described. A collimated detector, sensitive to certain wavelengths of light emission, is used to locate the centroid of the material with each pass of the gun. The response from the detector is then relayed to the gun controller to be used to automatically realign the gun

Electron gun for technological linear accelerator

International Nuclear Information System (INIS)

Khodak, I.V.; Kushnir, V.A.; Mirochenko, V.V.; Stepin, D.L.; Zavada, L.M.

2000-01-01

The work is purposed to the design of diode electron gun for powerful technologic electron linac and to experimental investigations of the beam parameters at the gun exit.The gun feature is the quick cathode replacement.This is very impotent for operating of the accelerator.The gun optics and beam parameters were calculated using the EGUN code.Beam parameters were investigated as at the special test stand so as component of the linac injector.The gun produces the beam current of 2 A at the anode voltage 25 kV.Measured beam parameters correspond to calculated results

Are "goods for guns" good for the community? An update of a community gun buyback program.

Science.gov (United States)

Green, Jonathan; Damle, Rachelle N; Kasper, Rebecca E; Violano, Pina; Manno, Mariann; Nazarey, Pradeep P; Aidlen, Jeremy T; Hirsh, Michael P

2017-08-01

Gun violence remains a leading cause of death in the United States. Community gun buyback programs provide an opportunity to dispose of extraneous firearms. The purpose of this study was to understand the demographics, motivation, child access to firearms, and household mental illness of buyback participants in hopes of improving the program's effectiveness. A 2015 Injury Free Coalition for Kids gun buyback program which collaborated with local police departments was studied. We administered a 23-item questionnaire survey to gun buyback participants assessing demographic characteristics, motivation for relinquishing firearms, child firearm accessibility, and mental illness/domestic violence history. A total of 186 individuals from Central/Western Massachusetts turned in 339 weapons. Participants received between US $25 and US $75 in gift cards dependent on what type of gun was turned in, with an average cost of $41/gun. A total of 109 (59%) participants completed the survey. Respondents were mostly white (99%), men (90%) and first-time participants in the program (85.2%). Among survey respondents, 54% turned in firearms "for safety reasons." Respondents reported no longer needing/wanting their weapons (47%) and approximately one in eight participants were concerned the firearm(s) were accessible to children. Most respondents (87%) felt the program encouraged neighborhood awareness of firearm safety. Three of every five participants reported that guns still remained in their homes; additionally, 21% where children could potentially access them and 14% with a history of mental illness/suicide/domestic violence in the home. Gun buybacks can provide a low-cost means of removing unwanted firearms from the community. Most participants felt their homes were safer after turning in the firearm(s). In homes still possessing guns, emphasis on secure gun storage should continue, increasing the safety of children and families. The results of this survey also provided new

The ALS Gun Electronics system

International Nuclear Information System (INIS)

Lo, C.C.

1993-05-01

The ALS Gun Electronics system has been designed to accommodate gun with a custom made socket and high speed electronics circuit which is capable of producing single and multiple electron bunches with time jitters measured at better than 50 PS. The system generates the gated RF signal at ground level before sending it up to the 120 KV-biased gun deck via a fiber optic cable. The current pulse width as a function of grid bias, using an Eimac 8847A planar triode simulating an electron gun, was measured to show the relationship between the two parameters

The ALS gun electronics system

International Nuclear Information System (INIS)

Lo, C.C.

1993-01-01

The ALS Gun Electronics system has been designed to accommodate the gun with a custom made socket and a high speed electronics circuit which is capable of producing single and multiple electron bunches with time jitters measured at better than 50 PS. The system generates the gated RF signal at ground level before sending it up to the 120 KV-biased gun deck via a fiber optic cable. The current pulse width as a function of grid bias, using an Eimac 8847A planar triode simulating an electron gun, was measured to show the relationship between the two parameters

Cofactory: Sequence-based prediction of cofactor specificity of Rossmann folds

DEFF Research Database (Denmark)

Geertz-Hansen, Henrik Marcus; Blom, Nikolaj; Feist, Adam

2014-01-01

Obtaining optimal cofactor balance to drive production is a challenge metabolically engineered microbial strains. To facilitate identification of heterologous enzymes with desirable altered cofactor requirements from native content, we have developed Cofactory, a method for prediction of enzyme...

Large-area thin self-supporting carbon foils with MgO coatings

CERN Document Server

Stolarz, A

2002-01-01

Large area self-supporting carbon foils in the thickness of range of 8-22 mu g/cm sup 2 , coated with approximately 4 mu g/cm sup 2 MgO have been prepared by e-gun evaporation. They were mounted on frames with apertures of 130 cm sup 2. Problems related to the parting agent preparation, floating procedure, and mounting onto frames are discussed. Special precautions necessary to avoid damage during foil drying, storage and transportation are suggested.

Large-area thin self-supporting carbon foils with MgO coatings

Energy Technology Data Exchange (ETDEWEB)

Stolarz, Anna E-mail: anna@slcj.uw.edu.pl; Maier-Komor, Peter

2002-03-11

Large area self-supporting carbon foils in the thickness of range of 8-22 {mu}g/cm{sup 2}, coated with approximately 4 {mu}g/cm{sup 2} MgO have been prepared by e-gun evaporation. They were mounted on frames with apertures of 130 cm{sup 2}. Problems related to the parting agent preparation, floating procedure, and mounting onto frames are discussed. Special precautions necessary to avoid damage during foil drying, storage and transportation are suggested.

Synthesis, crystal growth and structure of Mg containing β-rhombohedral boron: MgB17.4

International Nuclear Information System (INIS)

Adasch, Volker; Hess, Kai-Uwe; Ludwig, Thilo; Vojteer, Natascha; Hillebrecht, Harald

2006-01-01

For the first time, single crystals of Mg containing β-rhombohedral boron MgB 17.4 were synthesised from the elements in a Mg/Cu melt at 1600deg. C. The crystal structure determined by the refinement of single crystal data (space group R-3m, a=10.991(2)A, c=24.161(4)A, 890 reflections, 123 variables, R 1 (F)=0.049, wR 2 (I)=0.122) improves and modifies the former structure model derived from earlier investigations on powder samples. Mg is located on four different positions with partial occupation. While the occupation of the sites D (53.3%), E (91%) and F (7.2%) is already known from other boron-rich borides related to β-rhombohedral boron, the occupation of the fourth position (18h, 6.7%) is observed for the first time. Two boron positions show partial occupation. The summation reveals the composition MgB 17.4 and Mg 5.85 B 101.9 , respectively, confirmed by WDX measurements. The single crystals of MgB 17.4 show the highest Mg content ever found. Preliminary measurements indicate no superconductivity

Glue Guns: Aiming for Safety

Science.gov (United States)

Roy, Ken

2010-01-01

While glue guns are very useful, there are safety issues. Regardless of the temperature setting, glue guns can burn skin. The teacher should demonstrate and supervise the use of glue guns and have a plan should a student get burned. There should be an initial first aid protocol in place, followed by a visit to the school nurse. An accident report…

Crystallization and preliminary X-ray analysis of tubulin-folding cofactor A from Arabidopsis thaliana

International Nuclear Information System (INIS)

Lu, Lu; Nan, Jie; Mi, Wei; Wei, Chun-Hong; Li, Lan-Fen; Li, Yi

2010-01-01

Tubulin-folding cofactor A from A. thaliana has been crystallized and preliminarily analyzed using X-ray diffraction. Tubulin-folding cofactor A (TFC A) is a molecular post-chaperonin that is involved in the β-tubulin-folding pathway. It has been identified in many organisms including yeasts, humans and plants. In this work, Arabidopsis thaliana TFC A was expressed in Escherichia coli and purified to homogeneity. After thrombin cleavage, a well diffracting crystal was obtained by the sitting-drop vapour-diffusion method at 289 K. The crystal diffracted to 1.6 Å resolution using synchrotron radiation and belonged to space group I4 1 , with unit-cell parameters a = 55.0, b = 55.0, c = 67.4 Å

Molybdenum-cofactor deficiency: an easily missed cause of neonatal convulsions

NARCIS (Netherlands)

Slot, H. M.; Overweg-Plandsoen, W. C.; Bakker, H. D.; Abeling, N. G.; Tamminga, P.; Barth, P. G.; van Gennip, A. H.

1993-01-01

Intractable seizures in the neonatal period may be caused by molybdenum-cofactor deficiency, an inborn error which combines the deficiencies of sulphite oxidase and xanthine dehydrogenase. The neurological symptoms of molybdenum cofactor and isolated sulphite oxidase deficiencies are identical. Two

"Is there a gun in the home?" Assessing the risks of gun ownership in older adults.

Science.gov (United States)

Pinholt, Ellen M; Mitchell, Joshua D; Butler, Jane H; Kumar, Harjinder

2014-06-01

An important ethical and safety concern that geriatricians, primary care providers, and home health professionals need to address is gun ownership by elderly adults. Those aged 65 and older now have the highest rate of gun ownership in America, and they also have a high prevalence of depression and suicide. Dementia can add additional layers of risk. Even older gun owners who are otherwise intellectually intact may benefit from information about gun safety with the increasing numbers of children being cared for by grandparents. Health professionals should ask patients, "Is there a gun in the home?" in the clinic and during home visits. Healthcare professionals must have knowledge and skills to address safe gun ownership in elderly adults. The 5 L's (Locked, Loaded, Little children, feeling Low, Learned owner) will assist professionals in addressing all aspects of safe ownership. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

Mechanical Properties and Fabrication of Nanostructured Mg_2SiO_4-MgAl_2O_4 Composites by High-Frequency Induction Heated Combustion

International Nuclear Information System (INIS)

Shon, In-Jin; Kang, Hyun-Su; Hong, Kyung-Tae; Doh, Jung-Mann; Yoon, Jin-Kook

2011-01-01

Nanopowders of MgO, Al_2O_3 and SiO_2 were made by high energy ball milling. The rapid sintering of nanostructured MgAl_2O_4-Mg_2SiO_4 composites was investigated by a high-frequency induction heating sintering process. The advantage of this process is that it allows very quick densification to near theoretical density and inhibition of grain growth. Nanocrystalline materials have received much attention as advanced engineering materials with improved physical and mechanical properties. As nanomaterials possess high strength, high hardness, excellent ductility and toughness, undoubtedly, more attention has been paid for the application of nanomaterials. Highly dense nanostructured MgAl_2O_4-Mg_2SiO_4 composites were produced with simultaneous application of 80 MPa pressure and induced output current of total power capacity (15 kW) within 2 min. The sintering behavior, gain size and mechanical properties of MgAl_2O_4-Mg_2SiO_4 composites were investigated.

Gun buyback programs: a venue to eliminate unwanted guns in the community.

Science.gov (United States)

Violano, Pina; Driscoll, Cassandra; Chaudhary, Neil K; Schuster, Kevin M; Davis, Kimberly A; Borer, Esther; Winters, Jane K; Hirsh, Michael P

2014-09-01

The United States has a high rate of death due to firearms, and gun buyback programs may mitigate these high death rates. Understanding the demographics, motivation, and geographic region of participants may improve program efficacy. Three Injury Free Coalition for Kids gun buyback programs, in collaboration with the local police, were studied: Phoenix, Arizona; Worcester, Massachusetts; and New Haven, Connecticut. Participants were defined as those who relinquished a firearm. A self-administered, anonymous, paper survey elicited information from participants regarding demographic data, formal training on the use of the firearm, how the firearm was acquired, potential child access, knowledge of others injured by a firearm, whether the firearm was stored unlocked, factors motivating the surrender of the firearm, and other factors. Survey results were entered into a composite database and analyzed for differences in location, race, sex, and other factors. Participants (n = 301) were predominantly male (73.5%), white (80.9%), and older than 55 years (59.0%). They lived an average of 19.0 miles from the event by zip codes and had an average median household income of $65,731. More than half (54.5%) did not purchase the firearm, acquiring it through inheritance, gift, or random find. Most (74.8%) had previous firearms training and were relinquishing for safety reasons (68.3%). Those relinquishing firearms for safety reasons were less likely to have purchased the firearm (odds ratio [OR], 2.46, p gun lock (OR, 0.15; p gun-wielding criminal acts were burglarized from the home of legal gun owners that had failed to secure them properly. The gun buyback program is solely one prong of a multipronged approach in reducing firearm-based interpersonal violence. Additional research is necessary to determine effective methods to target individuals who would have the greatest impact on gun violence if they relinquished their weapons. Through the forging of relationships and

Isopiestic Investigation of the Osmotic and Activity Coefficients of {yMgCl2 + (1 - y)MgSO4}(aq) and the Osmotic Coefficients of Na2SO4.MgSO4(aq) at 298.15 K

Energy Technology Data Exchange (ETDEWEB)

Miladinovic, J; Ninkovic, R; Todorovic, M; Rard, J A

2007-06-06

Isopiestic vapor pressure measurements were made for {l_brace}yMgCl{sub 2} + (1-y)MgSO{sub 4}{r_brace}(aq) solutions with MgCl{sub 2} ionic strength fractions of y = 0, 0.1997, 0.3989, 0.5992, 0.8008, and (1) at the temperature 298.15 K, using KCl(aq) as the reference standard. These measurements for the mixtures cover the ionic strength range I = 0.9794 to 9.4318 mol {center_dot} kg{sup -1}. In addition, isopiestic measurements were made with NaCl(aq) as reference standard for mixtures of {l_brace}xNa{sub 2}SO{sub 4} + (1-x)MgSO{sub 4}{r_brace}(aq) with the molality fraction x = 0.50000 that correspond to solutions of the evaporite mineral bloedite (astrakanite), Na{sub 2}Mg(SO{sub 4}){sub 2} {center_dot} 4H{sub 2}O(cr). The total molalities, m{sub T} = m(Na{sub 2}SO{sub 4}) + m(MgSO{sub 4}), range from m{sub T} = 1.4479 to 4.4312 mol {center_dot} kg{sup -1} (I = 5.0677 to 15.509 mol {center_dot} kg{sup -1}), where the uppermost concentration is the highest oversaturation molality that could be achieved by isothermal evaporation of the solvent at 298.15 K. The parameters of an extended ion-interaction (Pitzer) model for MgCl2(aq) at 298.15 K, which were required for an analysis of the {l_brace}yMgCl{sub 2} + (1-y)MgSO{sub 4}{r_brace}(aq) mixture results, were evaluated up to I = 12.025 mol {center_dot} kg{sup -1} from published isopiestic data together with the six new osmotic coefficients obtained in this study. Osmotic coefficients of {l_brace}yMgCl{sub 2} + (1-y)MgSO{sub 4}{r_brace}(aq) solutions from the present study, along with critically-assessed values from previous studies, were used to evaluate the mixing parameters of the extended ion-interaction model.

Power-supply system for high-voltage electron guns with grid control

International Nuclear Information System (INIS)

Grigorev, Y.V.

1985-01-01

A power-supply system for electron guns with grid control is described which consists of a source of accelerating voltage between 20 and 180 kV with a current of 100 mA and a control circuit for an electron gun that contains a pulse generator having an output voltage of up to 5 kV for pulse durations of 2, 10, 50 and 90 microseconds. The output pulses of the generator are synchronized with a certain phase of the cathode heater current of the gun, and they can be repeated at a frequency between 100 and 0.4 Hz. The system is reliable and resistant to the overloads associated with breakdowns in the gun

Measurements of Transverse Emittance for RF Photocathode Gun at the PAL

CERN Document Server

Park Jang Ho; Park, Sung-Ju; Soo Ko In; Wang, Xijie; Woon Parc, Yong; Xiang, Dao

2005-01-01

A BNL GUN-IV type RF photo-cathode gun is under fabrication for use in the FIR (Far Infra-Red) facility being built at the Pohang Accelerator Laboratory (PAL). Performance test of the gun will include the measurement of transverse emittance profile along the longitudinal direction. Successful measurement of the emittance profile will provide powerful tool for the commissioning of the 4GLS (4th generation light source) injectors based on the emittance compensation principle. We are going to achieve this withthe use of pepper-pot based emittance meters that can be moved along the longitudinal direction. In this article, we present design considerations on the emittance meter with the resolution of 1 mm mrad.

Mechanistic insights into Mg2+-independent prenylation by CloQ from classical molecular mechanics and hybrid quantum mechanics/molecular mechanics molecular dynamics simulations.

Science.gov (United States)

Bayse, Craig A; Merz, Kenneth M

2014-08-05

Understanding the mechanism of prenyltransferases is important to the design of engineered proteins capable of synthesizing derivatives of naturally occurring therapeutic agents. CloQ is a Mg(2+)-independent aromatic prenyltransferase (APTase) that transfers a dimethylallyl group to 4-hydroxyphenylpyruvate in the biosynthetic pathway for clorobiocin. APTases consist of a common ABBA fold that defines a β-barrel containing the reaction cavity. Positively charged basic residues line the inside of the β-barrel of CloQ to activate the pyrophosphate leaving group to replace the function of the Mg(2+) cofactor in other APTases. Classical molecular dynamics simulations of CloQ, its E281G and F68S mutants, and the related NovQ were used to explore the binding of the 4-hydroxyphenylpyruvate (4HPP) and dimethylallyl diphosphate substrates in the reactive cavity and the role of various conserved residues. Hybrid quantum mechanics/molecular mechanics potential of mean force (PMF) calculations show that the effect of the replacement of the Mg(2+) cofactor with basic residues yields a similar activation barrier for prenylation to Mg(2+)-dependent APTases like NphB. The topology of the binding pocket for 4HPP is important for selective prenylation at the ortho position of the ring. Methylation at this position alters the conformation of the substrate for O-prenylation at the phenol group. Further, a two-dimensional PMF scan shows that a "reverse" prenylation product may be a possible target for protein engineering.

Instantaneous current and field structure of a gun-driven spheromak for two gun polarities

International Nuclear Information System (INIS)

Woodruff, S; Nagata, M

2002-01-01

The instantaneous plasma structure of the SPHEX spheromak is determined here by numerically processing data from insertable Rogowski and magnetic field probes. Data is presented and compared for two modes of gun operation: with the central electrode biased positively and negatively. It is found that while the mean-, or even instantaneous-, field structure would give the impression of a roughly axisymmetric spheromak, the instantaneous current structure does not. Hundred per cent variations in J measured at the magnetic axis can be explained by the rotation of a current filament that has a width equal to half of the radius of the flux-conserving first wall. In positive gun operation, current leaves the filament in the confinement region leading to high wall current there. In negative gun operation, wall current remains low as all injected current returns to the gun through the plasma. The plasma, in either instance, is strongly asymmetric. We discuss evidence for the existence of the current filament in other gun-driven spheromaks and coaxial plasma thrusters

Heavy duty plasma spray gun

International Nuclear Information System (INIS)

Irons, G.C.; Klein, J.F.; Lander, R.D.; Thompson, H.C.; Trapani, R.D.

1984-01-01

A heavy duty plasma spray gun for extended industrial service is disclosed. The gun includes a gas distribution member made of a material having a coefficient of expansion different from that of the parts surrounding it. The gas distribution member is forcibly urged by a resilient member such as a coiled spring against a seal so as to assure the plasma gas is introduced into the gun arc in a manner only defined by the gas distribution member. The gun has liquid cooling for the nozzle (anode) and the cathode. Double seals are provided between the coolant and the arc region and a vent is provided between the seals which provides an indication when a seal has failed. Some parts of the gun are electrically isolated from others by an intermediate member which is formed as a sandwich of two rigid metal face pieces and an insulator disposed between them. The metal face pieces provide a rigid body to attach the remaining parts in proper alignment therewith

LCLS Gun Solenoid Design Considerations

International Nuclear Information System (INIS)

Schmerge, John

2010-01-01

The LCLS photocathode rf gun requires a solenoid immediately downstream for proper emittance compensation. Such a gun and solenoid have been operational at the SSRL Gun Test Facility (GTF) for over eight years. Based on magnetic measurements and operational experience with the GTF gun solenoid multiple modifications are suggested for the LCLS gun solenoid. The modifications include adding dipole and quadrupole correctors inside the solenoid, increasing the bore to accommodate the correctors, decreasing the mirror plate thickness to allow the solenoid to move closer to the cathode, cutouts in the mirror plate to allow greater optical clearance with grazing incidence cathode illumination, utilizing pancake coil mirror images to compensate the first and second integrals of the transverse fields and incorporating a bipolar power supply to allow for proper magnet standardization and quick polarity changes. This paper describes all these modifications plus the magnetic measurements and operational experience leading to the suggested modifications.

77 FR 37834 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

Science.gov (United States)

2012-06-25

... Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION: Notice of proposed rulemaking. SUMMARY... compliance than our existing regulations pertaining to caps intended for use with toy guns and toy guns not...

Theoretical investigation of a travelling-wave rf gun

International Nuclear Information System (INIS)

Gao, J.

1991-12-01

A travelling-wave type rf gun (TW gun) is investigated theoretically. Analytical formulae concerning energy gain, energy spread, and transverse emittance are derived. After showing the corresponding formulae for the standing-wave rf gun (SW gun), comparisons are made between the two types of rf gun. Finally, some numerical results are calculated to demonstrate further the behaviours of the TW gun, and to compare with those from analytical formulae. (author) 11 refs.; 27 figs

One nanosecond pulsed electron gun systems

International Nuclear Information System (INIS)

Koontz, R.F.

1979-02-01

At SLAC there has been a continuous need for the injection of very short bunches of electrons into the accelerator. Several time-of-flight experiments have used bursts of short pulses during a normal 1.6 micro-second rf acceleration period. Single bunch beam loading experiments made use of a short pulse injection system which included high power transverse beam chopping equipment. Until the equipment described in this paper came on line, the basic grid-controlled gun pulse was limited to a rise time of 7 nanoseconds and a pulse width of 10 nanoseconds. The system described here has a grid-controlled rise time of less than 500 pico-seconds, and a minimum pulse width of less than 1 nanosecond. Pulse burst repetition rate has been demonstrated above 20 MHz during a 1.6 microsecond rf accelerating period. The order-of-magnitude increase in gun grid switching speed comes from a new gun design which minimizes lead inductance and stray capacitance, and also increases gun grid transconductance. These gun improvements coupled with a newly designed fast pulser mounted directly within the gun envelope make possible subnanosecond pulsing of the gun

Design and development of a pierce electron gun

International Nuclear Information System (INIS)

Bhattacharjee, D.; Tiwari, R.; Nayak, B.; Tillu, A.R.; Jayaprakash, D.; Mishra, R.L.; Mittal, K.C.; Chakravarthy, D.P.; Gantayet, L.M.

2011-01-01

An electron gun is designed and developed using the Pierce configuration for the focusing electrode. Simulations were carried out using CST Particle Studio. The Gun is a thermionic type electron gun with indirect heating of the LaB6 cathode. The gun is capable of delivering a beam current of 500 mA at 50 kV with a beam size of less than 3.5 mm. It was tested on the gun test bench. This paper presents the gun design, particle simulations study, testing of the gun on test bench and integration with the ECIL 9 MeV linac. (author)

Electron gun for the Fel Clio

International Nuclear Information System (INIS)

Chaput, R.

1990-01-01

A triode electron gun has been developed and manufactured at LURE (Laboratoire pour l'Utilisation du Rayonnement Electromagnetique) and LAL (Laboratoire de l'Accelerateur Lineaire) for the free electron laser CLIO 1 (Collaboration pour un laser a electrons libres dans l'infrarouge a Orsay) now under construction: this gun involves a grid-cathode assembly manufactured by EIMAC, currently used in the SLAC gun family. For the FEL requirements, the gun must be able to yield a train of short pulses at accuracy frequency or a continuous pulse. Driving together the cathode and the grid the gun produces a continous beam of 12 μs or a pulsed beam of very short pulse of 1 ns at 250 MHz, 125 MHz, 62.5 MHz or 31.25 MHz. The performances of the gun has been tested on a testing bench. A peak current of 1 Amp. for 1 ns width at any frequencies was achieved at an injection voltage of 90 kV

Results of the SLAC LCLS Gun High-Power RF Tests

International Nuclear Information System (INIS)

Dowell, D.H.; Jongewaard, E.; Limborg-Deprey, C.; Schmerge, J.F.; Li, Z.; Xiao, L.; Wang, J.; Lewandowski, J.; Vlieks, A.

2007-01-01

The beam quality and operational requirements for the Linac Coherent Light Source (LCLS) currently being constructed at SLAC are exceptional, requiring the design of a new RF photocathode gun for the electron source. Based on operational experience at SLAC's GTF and SDL and ATF at BNL as well as other laboratories, the 1.6cell s-band (2856MHz) gun was chosen to be the best electron source for the LCLS, however a significant redesign was necessary to achieve the challenging parameters. Detailed 3-D analysis and design was used to produce near-perfect rotationally symmetric rf fields to achieve the emittance requirement. In addition, the thermo-mechanical design allows the gun to operate at 120Hz and a 140MV/m cathode field, or to an average power dissipation of 4kW. Both average and pulsed heating issues are addressed in the LCLS gun design. The first LCLS gun is now fabricated and has been operated with high-power RF. The results of these high-power tests are presented and discussed

Gas gun dynamics

International Nuclear Information System (INIS)

Denny, Mark

2013-01-01

The mechanics and thermodynamics of one- and two-stage gas guns are developed. Very high projectile muzzle speed can be obtained by the two-stage version. The physics of simple gas guns, such as air rifles, is accessible to undergraduates and the same level of presentation is used here to understand more complex designs. Numerical solutions to the equations of motion are shown, along with insightful analytic approximations. (paper)

Alignment Fixtures For Vacuum-Plasma-Spray Gun

Science.gov (United States)

Woodford, William H.; Mckechnie, Timothy N.; Power, Christopher A.; Daniel, Ronald L., Jr.

1993-01-01

Fixtures for alignment of vacuum-plasma-spray guns built. Each fixture designed to fit specific gun and holds small, battery-powered laser on centerline of gun. Laser beam projects small red dot where centerline intersects surface of workpiece to be sprayed. After laser beam positioned on surface of workpiece, fixture removed from gun and spraying proceeds.

Bleaching herbicide norflurazon inhibits phytoene desaturase by competition with the cofactors.

Science.gov (United States)

Breitenbach, J; Zhu, C; Sandmann, G

2001-11-01

Cofactor requirement was determined for the heterologous expressed phytoene desaturases from the cyanobacterium Synechococcus and the higher plant Gentiana lutea. The cyanobacterial enzyme is dependent on either NAD(P) or plastoquinone, whereas only quinones such as plastoquinone can function as a cofactor for the phytoene desaturase from G. lutea. Enzyme kinetic studies were carried out to determine a possible competition between the cofactors and the bleaching herbicide norflurazon. For the Synechococcus enzyme, competition between norflurazon and NADP, as well as plastoquinone, could be demonstrated. The K(m) values for these cofactors were 6.6 mM and 0.23 microM, respectively. Inhibition of the phytoene desaturase from G. lutea by norflurazon was also competitive with respect to plastoquinone. The K(m) values of both enzymes for plastoquinone were very close.

GenBank blastn search result: AK069545 [KOME

Lifescience Database Archive (English)

Full Text Available AK069545 J023025I06 BD084915.1 DNA sequences encoding the subunit CHLD of plant magnesium... chelatases, and determining the activity of plant magnesium chelatases.|PAT PAT 4e-91 Plus Plus ...

Electron gun

International Nuclear Information System (INIS)

Chen, H.-Y.; Hughes, R.H.

1979-01-01

The invention described relates to cathode ray tubes, and particularly to color picture tubes of the type useful in home television receivers and therefore to electron guns. The invention is especially applicable to self-converging tube-yoke combinations with shadow mask tubes of the type having plural-beam in-line guns disposed in a horizontal plane, an apertured mask with vertically oriented slit-shaped apertures, and a screen with vertically oriented phosphor stripes. The invention is not, however, limited to use in such tubes and may in fact be used, e.g., in dot-type shadow mask tubes and index-type tubes. (Auth.)

Operation of the APS rf gun

International Nuclear Information System (INIS)

Lewellen, J. W.

1998-01-01

The Advanced Photon Source (APS) has a thermionic-cathode rf gun system capable of providing beam to the APS linac. The gun system consists of a 1.6-cell thermionic-cathode rf gun, a fast kicker for beam current control, and an alpha magnet for bunch compression and injection into the APS linac line. This system is intended for use both as an injector for positron creation, and as a first beam source for the Low-Energy Undulator Test Line (LEUTL) project [1]. The first measured performance characteristics of the gun are presented.

An electron gun with replaceable cathode-heater assembly for an E-beam irradiator

International Nuclear Information System (INIS)

Wu Xunlei; Yu Xiaojuan; Jiang Zhenbo

2011-01-01

A new type of electron guns has been developed for a 10 MeV 1.5 mA linac for radiation processing. The specifications required are: cathode voltage 60 kV, peak beam current 550-600 mA, spot size 4 mm, and working distance 60 mm. Particularly, this electron gun is advantageous in its replaceable cathode-heater assembly. This helps the customers to reduce their operation cost. The Egun and Mafia codes were used to simulate electromagnetic fields and electron trajectories. The guns were produced in the same technology of our klystron production. Design specifications of the gun were achieved in the beam current test and beam spot test. The first gun of this type has been working on an linac for about 3000 hours. (authors)

Middle Ground on Gun Control

Science.gov (United States)

2016-12-01

34 Australian Institute of Criminology, July 7, 2015, http://www.aic.gov.au/ statistics /homicide/weapon.html. 0 100 200 300 400 500 600 700 Total Gun...firearms is not the business of a single Australian , so it is immeasurably easier for politicians to categorically ban types of guns because there is...not an Australian version of Smith and Wesson that is going to be put out of business . Additionally, because all of the guns in Australia are

Electron-optical system of 200 kV gun for the VEPP-5 preinjector

International Nuclear Information System (INIS)

Akimov, V.E.; Kazarezov, I.V.; Tiunov, M.A.

2004-01-01

The electron gun with a new electron-optical system to match project parameters of the VEPP-5 preinjector is described. The gun produces the current with 10 A amplitude, pulse duration 2...3 ns at half-height and electron energy 200 keV. The gun has a dispenser cathode 20 mm in diameter and 100 mm spherical radius. The current control is performed by means of molybdenum equipotential grid with the cell size 0.4 centre dot 0.4 mm and optical transparency of about 0.68. The experimental results obtained are in good agreement with project parameters

Large-area cold-cathode grid-controlled electron gun for Antares

International Nuclear Information System (INIS)

Scarlett, W.R.; Andrews, K.; Jansen, J.

1979-01-01

The CO 2 laser amplifiers used in the Antares inertial confinement fusion project require large-area radial beams of high-energy electrons to ionize the laser medium before the main discharge pulse is applied. We have designed a grid-controlled, cold-cathode electron gun with a cylindrical anode having a window area of 9.3 m 2 . A full diameter, 1/4 length prototype of the Antares gun has been built and tested. The design details of the Antares electron gun will be presented as well as test results from the prototype. Techniques used for the prevention and control of emission and breakdown from the grid will also be discussed

Camouflaged Collectives: Managing Stigma and Identity at Gun Events

Directory of Open Access Journals (Sweden)

Sarah Jane Blithe

2017-02-01

Full Text Available Gun violence persists in the United States, claiming lives and escalating healthcare costs. This article seeks to contribute to social justice work on the “gun problem” by studying gun collectives. To understand gun culture and to identify gun violence reduction strategies, we study places where gun owners organize – legal (and sometimes illegal settings that facilitate dialogue about gun issues. Based on participant observation and collaborative event ethnography at gun shows and a private shooting party, this analysis presents findings about the practices gun collective members use to manage stigma. We conclude that when participants in gun events attempt to subvert core stigma through everyday stigma management practices, they effectively facilitate the unfettered exchange of potentially dangerous goods, promote the invisibility of oppressive structures, and normalize violence.

US-guided percutaneous biopsies with a biopsy gun

International Nuclear Information System (INIS)

Ahn, In Oak; Kim, Hyung Jin; Kim, Jae Hyung; Lee, Goo; Jung, Sung Hoon

1993-01-01

Core tissue for histologic study is believed by many pathologist to be more diagnostic than material from needle aspiration. Recently introduced automatched biopsy gun simplifies core biopsies with increased quantity and quality of samples. Authors performed 38 percutaneous biopsies from 38 patients with 18G automated biopsy guns under US guide. Diagnostic target tissues were obtained in 33 biopsies(87%), inadequate tissues in 4(11%), and adequate but not of target tissue in 1(3%). There was no major complication requiring treatment, but pain needing analgesics and pain with nausea/vomiting were experienced in 2 and 1 biopsies respectively. Average number of needle passes was 1.5. We concluded that US guided gun biopsy was a easy and safe way to obtain tissue samples of good quantity and quality, especially useful in hospitals without constant availability of specialist in cytopathology

Nail gun injuries to the head with minimal neurological consequences: a case series.

Science.gov (United States)

Makoshi, Ziyad; AlKherayf, Fahad; Da Silva, Vasco; Lesiuk, Howard

2016-03-16

An estimated 3700 individuals are seen annually in US emergency departments for nail gun-related injuries. Approximately 45 cases have been reported in the literature concerning nail gun injuries penetrating the cranium. These cases pose a challenge for the neurosurgeon because of the uniqueness of each case, the dynamics of high pressure nail gun injuries, and the surgical planning to remove the foreign body without further vascular injury or uncontrolled intracranial hemorrhage. Here we present four cases of penetrating nail gun injuries with variable presentations. Case 1 is of a 33-year-old white man who sustained 10 nail gunshot injuries to his head. Case 2 is of a 51-year-old white man who sustained bi-temporal nail gun injuries to his head. Cases 3 and 4 are of two white men aged 22 years and 49 years with a single nail gun injury to the head. In the context of these individual cases and a review of similar cases in the literature we present surgical approaches and considerations in the management of nail gun injuries to the cranium. Case 1 presented with cranial nerve deficits, Case 2 required intubation for low Glasgow Coma Scale, while Cases 3 and 4 were neurologically intact on presentation. Three patients underwent angiography for assessment of vascular injury and all patients underwent surgical removal of foreign objects using a vice-grip. No neurological deficits were found in these patients on follow-up. Nail gun injuries can present with variable clinical status; mortality and morbidity is low for surgically managed isolated nail gun-related injuries to the head. The current case series describes the surgical use of a vice-grip for a good grip of the nail head and controlled extraction, and these patients appear to have a good postoperative prognosis with minimal neurological deficits postoperatively and on follow-up.

Interpreting the empirical evidence on illegal gun market dynamics.

Science.gov (United States)

Braga, Anthony A; Wintemute, Garen J; Pierce, Glenn L; Cook, Philip J; Ridgeway, Greg

2012-10-01

Thousands of Americans are killed by gunfire each year, and hundreds of thousands more are injured or threatened with guns in robberies and assaults. The burden of gun violence in urban areas is particularly high. Critics suggest that the results of firearm trace data and gun trafficking investigation studies cannot be used to understand the illegal supply of guns to criminals and, therefore, that regulatory and enforcement efforts designed to disrupt illegal firearms markets are futile in addressing criminal access to firearms. In this paper, we present new data to address three key arguments used by skeptics to undermine research on illegal gun market dynamics. We find that criminals rely upon a diverse set of illegal diversion pathways to acquire guns, gun traffickers usually divert small numbers of guns, newer guns are diverted through close-to-retail diversions from legal firearms commerce, and that a diverse set of gun trafficking indicators are needed to identify and shut down gun trafficking pathways.

Experimental studies of coaxial plasma gun current

International Nuclear Information System (INIS)

Price, D.W.

1988-01-01

In this investigation of a coaxial plasma gun, plasma sheath currents and related behavior are examined. Plasma behavior in the gun affects gun characteristics. Plasma gun applications are determined by the plasma behavior. The AFWL PUFF capacitor bank (72 μF, 29 nH, 120 kV) drives the plasma gun using a deuterium fill gas. The gas breakdown site is isolated from the dielectric/vacuum interface in the AFWL system. Two gas values deliver gas in the system. The first delivers gas from the gun breech and the second optional valve delivers gas to the gun muzzle. Currents and voltages are measured by Rogowski coils, B probes and capacitive voltage probes. A O-D slug model is used to predict the current, inductance, gun voltage and plasma sheath velocity. The slug model assumes the sheath transits the gun with all mass in the sheath. In the snowplow mode, the plasma sheath is thin with a sharp current rise and drop. Our system operated in a transition mode between the snowplow and deflagration modes with early snowplow behavior and late deflagration behavior. Neutrons are produced in a plasma pinch at the gun muzzle, indicating snowplow behavior. The slug theory models overall gun behavior to experimental accuracy. Experimental results are compared to four theories for plasma sheath velocities: the Alfven collisionally limited model, the Rosenbluth model, the Fishbine saturated model and a single particle drift model. Experimental velocities vary from 10 5 to 10 6 m/s. Only the single particle drift and the slug model calculations are of the right magnitude (8 x 10 5 m/s). The Fishbine and the Rosenbluth models predict slower velocities (2 x 10 5 m/s). The Alfven model is not applicable to this system

Gun Safety (For Parents)

Science.gov (United States)

... from the home of a relative or friend. Teens should never be able to get to a gun and bullets without an adult being there. People of any age who are depressed are at increased risk of suicide. If someone in the family has depression, or has had thoughts of suicide, all guns ...

Remotely controlled spray gun

Science.gov (United States)

Cunningham, William C. (Inventor)

1987-01-01

A remotely controlled spray gun is described in which a nozzle and orifice plate are held in precise axial alignment by an alignment member, which in turn is held in alignment with the general outlet of the spray gun by insert. By this arrangement, the precise repeatability of spray patterns is insured.

Repetitive, small-bore two-stage light gas gun

International Nuclear Information System (INIS)

Combs, S.K.; Foust, C.R.; Fehling, D.T.; Gouge, M.J.; Milora, S.L.

1991-01-01

A repetitive two-stage light gas gun for high-speed pellet injection has been developed at Oak Ridge National Laboratory. In general, applications of the two-stage light gas gun have been limited to only single shots, with a finite time (at least minutes) needed for recovery and preparation for the next shot. The new device overcomes problems associated with repetitive operation, including rapidly evacuating the propellant gases, reloading the gun breech with a new projectile, returning the piston to its initial position, and refilling the first- and second-stage gas volumes to the appropriate pressure levels. In addition, some components are subjected to and must survive severe operating conditions, which include rapid cycling to high pressures and temperatures (up to thousands of bars and thousands of kelvins) and significant mechanical shocks. Small plastic projectiles (4-mm nominal size) and helium gas have been used in the prototype device, which was equipped with a 1-m-long pump tube and a 1-m-long gun barrel, to demonstrate repetitive operation (up to 1 Hz) at relatively high pellet velocities (up to 3000 m/s). The equipment is described, and experimental results are presented. 124 refs., 6 figs., 5 tabs

A Raman spectroscopic study of the structural aspects of K2MgCl4 and Cs2MgCl4 as solid single crystals and molten salts

International Nuclear Information System (INIS)

Brooker, M.H.

1975-01-01

Polarized Raman spectra have been obtained for oriented single crystals of K 2 MgCl 4 and Cs 2 MgCl 4 at 77 and 298 K. The data are in excellent agreement with factor group analyses based on the space groups I 4 /mmm (D 17 4 /subh/) and Pnma (D 16 2 /subh/) for the K 2 MgCl 4 and Cs 2 MgCl 4 crystals. In K 2 MgCl 4 the magnesium is surrounded by six chloride ions in a distorted octahedral arrangement with a network structure such that neighboring octahedra share corners. In Cs 2 MgCl 4 a discrete tetrahedral MgCl 4 2- species is present. The 35 Cl-- 37 Cl isotopic splitting of the symmetric stetching mode of the tetrahedral MgCl 4 2- species has been resolved at 77 K and is similar to that observed for CCl 4 . Raman spectra for the high temperature solids and molten salts suggest that the coordination number of magnesium changes from six in solid K 2 MgCl 4 to four in the melt, whereas Cs 2 MgCl 4 melts with retention of the MgCl 4 2- tetrahedral complex. Additional evidence is presented to support previous reports that the MgCl 4 2- tetrahedral species is the principal complex ion in the melts, although a fraction of the magnesium appears to be present in a polynuclear complex, perhaps Mg 2 Cl 6 2-

Conceptual Design for CLIC Gun Pulser

Energy Technology Data Exchange (ETDEWEB)

Tang, Tao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

2016-01-08

The Compact Linear Collider (CLIC) is a proposed future electron-positron collider, designed to perform collisions at energies from 0.5 to 5 TeV, with a nominal design optimized for 3 TeV (Dannheim, 2012). The Drive Beam Accelerator consists of a thermionic DC gun, bunching section and an accelerating section. The thermionic gun needs deliver a long (~143us) pulse of current into the buncher. A pulser is needed to drive grid of the gun to generate a stable current output. This report explores the requirements of the gun pulser and potential solutions to regulate grid current.

Fueling by coaxial plasma guns

International Nuclear Information System (INIS)

Marshall, J.

1978-01-01

The operating principles of pulsed coaxial guns are reviewed. Some problems involved with the injection of plasma beams from these guns into containment fields are described. The injection during reactor operating conditions is then discussed

New Electron Gun System for BEPCII

CERN Document Server

Liu, Bo; Long Chi, Yun; Zhang, Chuang

2005-01-01

The new electron gun system for BEPCII has been put into operation since Nov. 2004. The article describes the design, experiment and operation of this new system. The design current of the gun is 10 A for the pulse lengths of 1 ns, 2.5 ns and 1 μs with repetition rate of 50 Hz. The gun is operated with a pulsed high voltage power supply which can provide up to 200 kV high voltage. Computer simulations have been carried out in the design stage, including simulation of the gun geometry and beam transportation. Some important relation curves are obtained during the experiment. Two-bunch operation is available and some elementary tests have been performed. New scheme of the gun control system based on EPICS is also presented. The real operation shows that the design and manufacturing is basically successful.

120 Hz Gun Review

Energy Technology Data Exchange (ETDEWEB)

Colby, E.

2005-01-31

The review was held at SLAC on September 11 and 12, 2001. Presentations concerning the thermal analysis, mechanical design, integration with the laser and accelerator, general beam dynamics considerations, a load lock mechanism, and symmetric power feed options comprised the review. Slides from these presentations are available elsewhere. The review committee was charged with evaluating the 120 Hz gun design including proposed load lock and power feed options and recommending improvements. Broader evaluation of the injector as a whole (including focusing and diagnostic systems that do no impact the envelope of the gun itself) is expected to be covered in a future review and will not be commented on here. In general, the long operational experience with four generations of s-band RF guns at numerous labs worldwide has led to considerable experience in design, fabrication, and operation aspects, and provides an excellent base on which to design the higher duty factor LCLS injector. While open questions remain on obtaining the design performance from these injectors, the microwave design of the gun has reached a state of relative maturity.

Production of thermoluminescent dosemeters based on MgB4O7: Dy and MgB4O7: Tm

International Nuclear Information System (INIS)

Souza, Luiza Freire de; Souza, Divanizia N.

2013-01-01

The thermoluminescent dosimetry (TL) is a well-established technique for the detection of ionizing radiation in hospitals, clinics, and industrial establishments where there is the need to quantify the radiation. For this practice is require the use phosphors which are sensitive to radiation. Some phosphors are already commonly used in this practice, for example, TLD-100 (LiF: Mg, Ti), CaSO 4 :Tm and CaSO 4 :Dy. A compound that was most recently introduced in dosimetry and has many advantageous features to detect neutrons, electrons and gamma is the magnesium tetraborate (MgB 4 O 7 ), but the undoped material is not good for dosimetry, since signal does not show satisfactory thermoluminescence. The present work presents the analysis of the compound MgB 4 O 7 when doped with rare earth elements, thulium (Tm) and dysprosium (Dy). The production of MgB 4 O 7 : Dy and MgB 4 O 7 : Tm occurred under acidic conditions. Following the process of crystal growth, several tests were made on phosphors produced to verify the quality of materials as TL dosimeter. Initially, was made the identification of the crystalline phases found in the material, using the technique of X-ray diffractometry, and then were evaluated and compared the TL emission curves of the crystals with two different types of dopants, to this, the samples were irradiated with different radiation sources: 137 Cs (0,66 MeV), 60 Co (1.25 MeV) and X-rays (0.41 MeV) and based on the results was evaluated the energy dependence of phosphors. Another characteristic analyzed, was the decay of TL signal for the material (fading). The results show that the material can be an excellent TL dosimeter when doped with rare earth elements Dy and Tm. (author)

Self-bunching electron guns

Science.gov (United States)

Mako, Frederick M.; Len, L. K.

1999-05-01

We report on three electron gun projects that are aimed at power tube and injector applications. The purpose of the work is to develop robust electron guns which produce self-bunched, high-current-density beams. We have demonstrated, in a microwave cavity, self-bunching, cold electron emission, long life, and tolerance to contamination. The cold process is based on secondary electron emission. FMT has studied using simulation codes the resonant bunching process which gives rise to high current densities (0.01-5 kA/cm2), high charge bunches (up to 500 nC/bunch), and short pulses (1-100 ps) for frequencies from 1 to 12 GHz. The beam pulse width is nominally ˜5% of the rf period. The first project is the L-Band Micro-Pulse Gun (MPG). Measurements show ˜40 ps long micro-bunches at ˜20 A/cm2 without contamination due to air exposure. Lifetime testing has been carried out for about 18 months operating at 1.25 GHz for almost 24 hours per day at a repetition rate of 300 Hz and 5 μs-long macro-pulses. Approximately 5.8×1013 micro-bunches or 62,000 coulombs have passed through this gun and it is still working fine. The second project, the S-Band MPG, is now operational. It is functioning at a frequency of 2.85 GHz, a repetition rate of 30 Hz, with a 2 μs-long macro-pulse. It produces about 45 A in the macro-pulse. The third project is a 34.2 GHz frequency-multiplied source driven by an X-Band MPG. A point design was performed at an rf output power of 150 MW at 34.2 GHz. The resulting system efficiency is 53% and the gain is 60 dB. The system efficiency includes the input cavity efficiency, input driver efficiency (a 50 MW klystron at 11.4 GHz), output cavity efficiency, and the post-acceleration efficiency.

Gun Violence, mental health, and Connecticut physicians.

Science.gov (United States)

Dodds, Peter R; Anderson, Caitlyn O; Dodds, Jon H

2014-01-01

While there is a public perception that gun violence is associated with mental illness we present evidence that it is a complex public health problem which defies simple characterizations and solutions. Only a small percentage of individuals with mental illness are at risk for extreme violence and they account for only a small percentage of gun-related homicides. Individuals who are at risk for gun violence are difficult to identify and successfully treat. The incidence, and perhaps the demographics, of gun violence vary substantially from state to state. We make a case for Connecticut physicians to study gun violence at the state level. We recommend that Connecticut physicians promote and expand upon the American Academy of Pediatrics' recommendation for creating a "safe home environment. "We suggest that guns be secured in all homes in which there are children. In addition we suggest that guns be voluntarily removed from homes in which there are individuals with a history of violence, threats of violence, depression, drug and/or alcohol abuse, and individuals with major mental illnesses who are not cooperating with therapy.

Electric rail gun application to space propulsion

International Nuclear Information System (INIS)

Barber, J.P.

1979-01-01

The paper examines the possibility of using the DC electric gun principles as a space vehicle propulsion system, capable of producing intermediate thrust levels. The application of an electromagnetic launch technique, called the DC electric rail gun, to the space propulsion concept of O'Neill, is examined. It is determined that the DC electric rail gun offers very high projectile accelerations and a very significant potential for reducing the size and mass of a reaction motor for space application. A detailed description of rail gun principles is given and some simple expressions for the accelerating force, gun impedance, power supply requirements, and system performance are discussed

Experimental Studies of Electrothermal Plasma Gun

International Nuclear Information System (INIS)

Diab, F.B.A.

2013-01-01

The aim of the present work is to study the capillary plasma discharge dynamics and characteristics. The capillary plasma device is a new technology for producing high density plasma after ablating the capillary wall using a pulsed electric power. An Electrothermal Plasma Gun (ETG) is composed of a capillary discharge tube made of Teflon operated with simple RLC circuit. The device called Electrothermal Gun (ETG) which is composed of 4 capacitors (70 μF, 10 kV, 1.28 μH) connected in parallel to a plasma source by means of one high power supply. The gun was operated in open air at discharge energies between 35 J - 3.5 kJ according to charging voltage. The work presented in this thesis covers the following items, 1- Measurements of the basic parameters and characterizations of the pretest results of the electrical circuits and capillary plasma discharge using Rogowski coil, voltage probe and Photomultiplier. 2- Material processing including (physics of the surface modifications, the morphology of the surface by using Scanning Electron Microscope (SEM) at different conditions, compositions of the materials by using X-ray Fluorescence (XRF), Micro hardness test and material particle deposition.

Association Between Substance Use and Gun-Related Behaviors.

Science.gov (United States)

Chen, Danhong; Wu, Li-Tzy

2016-01-01

Gun-related violence is a public health concern. This study synthesizes findings on associations between substance use and gun-related behaviors. Searches through PubMed, Embase, and PsycINFO located 66 studies published in English between 1992 and 2014. Most studies found a significant bivariate association between substance use and increased odds of gun-related behaviors. However, their association after adjustment was mixed, which could be attributed to a number of factors such as variations in definitions of substance use and gun activity, study design, sample demographics, and the specific covariates considered. Fewer studies identified a significant association between substance use and gun access/possession than other gun activities. The significant association between nonsubstance covariates (e.g., demographic covariates and other behavioral risk factors) and gun-related behaviors might have moderated the association between substance use and gun activities. Particularly, the strength of association between substance use and gun activities tended to reduce appreciably or to become nonsignificant after adjustment for mental disorders. Some studies indicated a positive association between the frequency of substance use and the odds of engaging in gun-related behaviors. Overall, the results suggest a need to consider substance use in research and prevention programs for gun-related violence. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Nicotine chewing gum (2 mg, 4 mg) and cigarette smoking: comparative effects upon vigilance and heart rate.

Science.gov (United States)

Parrott, A C; Winder, G

1989-01-01

Sixteen male smokers, abstinent the morning before testing, were assessed under four conditions: placebo chewing gum, 2 mg nicotine chewing gum, 4 mg nicotine gum, and cigarette smoking. Placebo gum was administered in the cigarette condition, while sham smoking occurred in the gum conditions. Pre-drug administration and post-drug difference scores were calculated for each assessment measure: rapid visual information processing (RVIP), memory for new information, and heart rate. Nicotine raised heart rate in a significant monotonic dose-related manner (P less than 0.001): placebo +0.2; 2 mg gum +5.1; 4 mg gum +9.8; cigarette +17.5 bpm. Rapid visual information processing target detections were also significantly related to dose (P less than 0.01), with this increased vigilance significant under 4 mg nicotine gum and cigarette smoking. Memory task performance was not significantly affected. Self-reported feelings of alertness/energy were higher while smoking than under placebo or 4 mg gum. Complaints about the taste of the 4 mg nicotine gum were frequent.

The effects of pulse pressure from seismic water gun technology on Northern Pike

Science.gov (United States)

Gross, Jackson A.; Irvine, Kathryn M.; Wilmoth, Siri K.; Wagner, Tristany L.; Shields, Patrick A; Fox, Jeffrey R.

2013-01-01

We examined the efficacy of sound pressure pulses generated from a water gun for controlling invasive Northern Pike Esox lucius. Pulse pressures from two sizes of water guns were evaluated for their effects on individual fish placed at a predetermined random distance. Fish mortality from a 5,620.8-cm3 water gun (peak pressure source level = 252 dB referenced to 1 μP at 1 m) was assessed every 24 h for 168 h, and damage (intact, hematoma, or rupture) to the gas bladder, kidney, and liver was recorded. The experiment was replicated with a 1,966.4-cm3 water gun (peak pressure source level = 244 dB referenced to 1 μP at 1 m), but fish were euthanized immediately. The peak sound pressure level (SPLpeak), peak-to-peak sound pressure level (SPLp-p), and frequency spectrums were recorded, and the cumulative sound exposure level (SELcum) was subsequently calculated. The SPLpeak, SPLp-p, and SELcum were correlated, and values varied significantly by treatment group for both guns. Mortality increased and organ damage was greater with decreasing distance to the water gun. Mortality (31%) by 168 h was only observed for Northern Pike exhibiting the highest degree of organ damage. Mortality at 72 h and 168 h postexposure was associated with increasing SELcum above 195 dB. The minimum SELcum calculated for gas bladder rupture was 199 dB recorded at 9 m from the 5,620.8-cm3 water gun and 194 dB recorded at 6 m from the 1,966.4-cm3water gun. Among Northern Pike that were exposed to the large water gun, 100% of fish exposed at 3 and 6 m had ruptured gas bladders, and 86% exposed at 9 m had ruptured gas bladders. Among fish that were exposed to pulse pressures from the smaller water gun, 78% exhibited gas bladder rupture. Results from these initial controlled experiments underscore the potential of water guns as a tool for controlling Northern Pike.

Brief use of a specific gun in a violent game does not affect attitudes towards that gun.

Science.gov (United States)

Hilgard, Joseph; Engelhardt, Christopher R; Bartholow, Bruce D

2016-11-01

Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) could influence players' attitudes towards the AR-15 specifically and gun ownership in general. College undergraduates ( N  = 176) played one of four modified video games in a 2 (gun: AR-15 or science-fiction control) × 2 (gun power: strong or weak) between-subjects design. Despite collecting many outcomes and examining many potential covariates and moderators, experimental assignment did little to influence outcomes of product evaluations or purchasing intentions with regard to the AR-15. Attitudes towards public policy and estimation of gun safety were also not influenced by experimental condition, although these might have been better tested by comparison against a no-violence control condition. By contrast, gender and political party had dramatic associations with all outcomes. We conclude that, if product placement shapes attitudes towards firearms, such effects will need to be studied with stronger manipulations or more sensitive measures.

Brief use of a specific gun in a violent game does not affect attitudes towards that gun

Science.gov (United States)

Engelhardt, Christopher R.; Bartholow, Bruce D.

2016-01-01

Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) could influence players' attitudes towards the AR-15 specifically and gun ownership in general. College undergraduates (N = 176) played one of four modified video games in a 2 (gun: AR-15 or science-fiction control) × 2 (gun power: strong or weak) between-subjects design. Despite collecting many outcomes and examining many potential covariates and moderators, experimental assignment did little to influence outcomes of product evaluations or purchasing intentions with regard to the AR-15. Attitudes towards public policy and estimation of gun safety were also not influenced by experimental condition, although these might have been better tested by comparison against a no-violence control condition. By contrast, gender and political party had dramatic associations with all outcomes. We conclude that, if product placement shapes attitudes towards firearms, such effects will need to be studied with stronger manipulations or more sensitive measures. PMID:28018611

Nail gun injuries among construction workers.

Science.gov (United States)

Dement, John M; Lipscomb, Hester; Li, Leiming; Epling, Carol; Desai, Tejas

2003-05-01

Pneumatic nail guns greatly increase worker productivity and are extensively used in wood frame building construction, with especially high use in residential construction. One surveillance report of nail gun injuries in Washington State has been published; however, other literature consists largely of case reports and case series in trauma journals. The major objective of the current study was to investigate the occurrence of nail gun-associated injuries among construction workers and to identify preventable work-related factors associated with these injuries. Nail gun-related injuries occurring among a cohort of 13,347 carpenters in Ohio who worked union hours during the time period January 1, 1994, until September 30, 1997, were identified by matching the cohort with workers' compensation claims made to the Ohio Bureau of Workers' Compensation. We also analyzed workers' compensation claims for North Carolina Home Builders Association members for the period July 1996-November 1999 to identify nail gun-related injuries. Analyses included stratified analyses of claims by nature and body part injured, calculation of nail gun injury rates, and analyses of free text descriptions of injuries. Overall, nail gun injuries were responsible for 3.9 percent of workers' compensation claims with 8.3 percent to 25.5 percent of claims involving paid lost work time. The overall rate of nail gun injuries (cases per 200,000 work hours) was 0.33 in North Carolina and 0.26 in Ohio, reflecting the greater concentration of wood frame construction workers in the North Carolina population studied. Higher rates of injury were observed for carpenters in North Carolina and among residential carpenters in Ohio. The predominant body part injured was the hands/fingers, with 80 to 89 percent of injuries being nail punctures. Analyses of free text information for puncture injuries found approximately 70 percent of injuries to occur during the framing/sheathing stage of construction. Our data

Comparing the Electrochemical Performance of LiFePO4/C Modified by Mg Doping and MgO Coating

Directory of Open Access Journals (Sweden)

Jianjun Song

2013-01-01

Full Text Available Supervalent cation doping and metal oxide coating are the most efficacious and popular methods to optimize the property of LiFePO4 lithium battery material. Mg-doped and MgO-coated LiFePO4/C were synthesized to analyze their individual influence on the electrochemical performance of active material. The specific capacity and rate capability of LiFePO4/C are improved by both MgO coating and Mg doping, especially the Mg-doped sample—Li0.985Mg0.015FePO4/C, whose discharge capacity is up to 163 mAh g−1, 145.5 mAh g−1, 128.3 mAh g−1, and 103.7 mAh g−1 at 1 C, 2 C, 5 C, and 10 C, respectively. The cyclic life of electrode is obviously increased by MgO surface modification, and the discharge capacity retention rate of sample LiFePO4/C-MgO2.5 is up to 104.2% after 100 cycles. Comparing samples modified by these two methods, Mg doping is more prominent on prompting the capacity and rate capability of LiFePO4, while MgO coating is superior in terms of improving cyclic performance.

Rail gun powered by an integral explosive generator

International Nuclear Information System (INIS)

Peterson, D.R.; Fowler, C.M.

1979-01-01

We propose the use of a rail gun powered by an explosive magnetic flux compression generator built into the rail gun itself in which the rails of the gun are driven together behind the projectile by explosives. The magnetic field established between the rails by an initial current supplied by an external source at the breech of the gun is trapped and compressed by the collapsing rails to accelerate the projectile down the bore of the gun

Expression and localization of tubulin cofactors TBCD and TBCE in human gametes.

Science.gov (United States)

Jiménez-Moreno, Victoria; Agirregoitia, Ekaitz

2017-06-01

The tubulin cofactors TBCD and TBCE play an essential role in regulation of the microtubule dynamics in a wide variety of somatic cells, but little information is known about the expression of these cofactors in human sperm and oocytes. In this study, we focused on the investigation of the presence of, and the differential distribution of, the tubulin cofactors TBCD and TBCE in human sperm and during human oocyte maturation. We performed expression assays for TBCD and TBCE by reverse transcription-polymerase chain reaction (RT-PCR), western blot and immunofluorescence and verified the presence of both cofactors in human gametes. TBCD and TBCE were located mainly in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. The mRNA of both tubulin cofactors were present in the human oocytes but not in sperm cells. This finding gives a first insight into where TBCD and TBCE could carry out their function in the continuous changes that the cytoskeleton experiences during gametogenesis and also prior to fertilization.

Development of a Gun Wear Data Bank.

Science.gov (United States)

1979-11-01

GO TO 3 INC.(j)zI 3 CONTINUE *4OLS=MF( ICCIr RETURN ENTRY SEL4 Jug C0 4 IIRKIN,IRPAX IJ=79 .AND. ISERS (1,1) 00 5 19219" IF (ZJ *EO. KODE (19)) GO TO 6... SEL4 will find data for each requested gun that also meets the requirements for selected records. 2. SUBROUTINE RBU will unpack velocity data for a

Rate control for electron gun evaporation

International Nuclear Information System (INIS)

Schellingerhout, A.J.G.; Janocko, M.A.; Klapwijk, T.M.; Mooij, J.E.

1989-01-01

Principles for obtaining high-quality rate control for electron gun evaporation are discussed. The design criteria for rate controllers are derived from this analysis. Results are presented which have been obtained with e-guns whose evaporation rate is controlled by a Wehnelt electrode or by sweeping of the electron beam. Further improvements of rate stability can be obtained by improved design of e-guns and power supplies

Background Checks for all Gun Buyers and Gun Violence Restraining Orders: State Efforts to Keep Guns from High-Risk Persons.

Science.gov (United States)

Vernick, Jon S; Alcorn, Ted; Horwitz, Joshua

2017-03-01

There were more than 36,000 firearm-related deaths in the U.S. in 2015. Under federal law, a background check is required only for gun purchases from licensed dealers. Research suggests that some persons prohibited from owning a gun turn to private sellers, including those identified online, to attempt to obtain a firearm. State-level approaches to make it more difficult for high-risk persons to purchase or possess firearms include universal background check (UBC) and gun violence restraining order (GVRO) laws. UBC laws, on the books in 18 states as of the end of 2016, can reduce both homicide and suicide rates. After Colorado adopted a UBC law in 2013, the number of background checks conducted by private sellers for sales occurring at places other than gun shows steadily increased. GVRO laws give law enforcement and families the authority to petition a court to temporarily remove firearms from an individual who presents a danger to himself or others during times of crisis, regardless of whether that person has been diagnosed with a mental illness. California enacted a GVRO law in 2014. Data are emerging to suggest the effectiveness of GVRO-type laws at averting suicides and providing an entryway to services.

Testing a GaAs cathode in SRF gun

International Nuclear Information System (INIS)

Wang, E.; Kewisch, J.; Ben-Zvi, I.; Burrill, A.; Rao, T.; Wu, Q.; Holmes, D.

2011-01-01

RF electron guns with a strained superlattice GaAs cathode are expected to generate polarized electron beams of higher brightness and lower emittance than do DC guns, due to their higher field gradient at the cathode's surface and lower cathode temperature. We plan to install a bulk GaAs:Cs in a SRF gun to evaluate the performance of both the gun and the cathode in this environment. The status of this project is: In our 1.3 GHz 1/2 cell SRF gun, the vacuum can be maintained at nearly 10 -12 Torr because of cryo-pumping at 2K. With conventional activation of bulk GaAs, we obtained a QE of 10% at 532 nm, with lifetime of more than 3 days in the preparation chamber and have shown that it can survive in transport from the preparation chamber to the gun. The beam line has been assembled and we are exploring the best conditions for baking the cathode under vacuum. We report here the progress of our test of the GaAs cathode in the SRF gun. Future particle accelerators, such as eRHIC and the ILC require high-brightness, high-current polarized electrons. Strained superlattice GaAs:Cs has been shown to be an efficient cathode for producing polarized electrons. Activation of GaAs with Cs,O(F) lowers the electron affinity and makes it energetically possible for all the electrons, excited into the conduction band that drift or diffuse to the emission surface, to escape into the vacuum. Presently, all operating polarized electron sources, such as the CEBAF, are DC guns. In these devices, the excellent ultra-high vacuum extends the lifetime of the cathode. However, the low field gradient on the photocathode's emission surface of the DC guns limits the beam quality. The higher accelerating gradients, possible in the RF guns, generate a far better beam. Until recently, most RF guns operated at room temperature, limiting the vacuum to ∼10 -9 Torr. This destroys the GaAs's NEA surface. The SRF guns combine the excellent vacuum conditions of DC guns and the high accelerating

Extended suicide using an atypical stud gun.

Science.gov (United States)

Hagemeier, L; Schyma, C; Madea, B

2009-08-10

Suicides with stud guns are uncommon, but are well documented in the literature. On rare occasions, stud guns are also used as a homicide weapon. This case report describes an extended suicide in which a husband killed his wife and their two dogs, which lived on the property. The husband then committed suicide with a shot from the stud gun into his skull. He was a 70-year-old pensioner, a retired butcher, who was found by his son. He was lying in a supine position on a carpet in the living room, with the stud gun stuck in his skull. During autopsy, high concentrations of an antihistamine were found in the blood of each corpse; this drug is used as a soporific. In contrast to the literature, which mainly describes powder deposits due to the use of conventional stud guns, in this case a stud gun was used in which the expanding gases and powder escaped together with the central bolt at the front of the device; powder drains were not involved. Detailed findings of the autopsy are given with reference to this type of stud gun.

Ready, Fire, Aim: The College Campus Gun Fight

Science.gov (United States)

Birnbaum, Robert

2013-01-01

The question of whether guns should be permitted on college and university campuses in the United States reflects the tension between two competing perspectives. America has both a robust gun culture and an equally robust (if less well known) gun-control culture. The gun culture is as American as apple pie: There may be as many as 300 million…

A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.

Science.gov (United States)

Tiefenbach, Jens; Moll, Pamela R; Nelson, Meryl R; Hu, Chun; Baev, Lilia; Kislinger, Thomas; Krause, Henry M

2010-03-22

Nuclear receptors (NRs) belong to a superfamily of transcription factors that regulate numerous homeostatic, metabolic and reproductive processes. Taken together with their modulation by small lipophilic molecules, they also represent an important and successful class of drug targets. Although many NRs have been targeted successfully, the majority have not, and one third are still orphans. Here we report the development of an in vivo GFP-based reporter system suitable for monitoring NR activities in all cells and tissues using live zebrafish (Danio rerio). The human NR fusion proteins used also contain a new affinity tag cassette allowing the purification of receptors with bound molecules from responsive tissues. We show that these constructs 1) respond as expected to endogenous zebrafish hormones and cofactors, 2) facilitate efficient receptor and cofactor purification, 3) respond robustly to NR hormones and drugs and 4) yield readily quantifiable signals. Transgenic lines representing the majority of human NRs have been established and are available for the investigation of tissue- and isoform-specific ligands and cofactors.

A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.

Directory of Open Access Journals (Sweden)

Jens Tiefenbach

2010-03-01

Full Text Available Nuclear receptors (NRs belong to a superfamily of transcription factors that regulate numerous homeostatic, metabolic and reproductive processes. Taken together with their modulation by small lipophilic molecules, they also represent an important and successful class of drug targets. Although many NRs have been targeted successfully, the majority have not, and one third are still orphans. Here we report the development of an in vivo GFP-based reporter system suitable for monitoring NR activities in all cells and tissues using live zebrafish (Danio rerio. The human NR fusion proteins used also contain a new affinity tag cassette allowing the purification of receptors with bound molecules from responsive tissues. We show that these constructs 1 respond as expected to endogenous zebrafish hormones and cofactors, 2 facilitate efficient receptor and cofactor purification, 3 respond robustly to NR hormones and drugs and 4 yield readily quantifiable signals. Transgenic lines representing the majority of human NRs have been established and are available for the investigation of tissue- and isoform-specific ligands and cofactors.

DC photoemission electron guns as ERL sources

International Nuclear Information System (INIS)

Sinclair, Charles K.

2006-01-01

Very-high-voltage DC electron guns, delivering moderate duration bunches from photoemission cathodes, and followed by conventional drift bunching and acceleration, offer a practical solution for an ERL injector. In a variant of this scheme, a DC gun is placed in close proximity to a superconducting RF accelerator cavity, with few or no active elements between the gun and cavity. The principal technical challenge with such electron guns arises from field emission from the cathode electrode and its support structure. Field emission may result in voltage breakdown across the cathode-anode gap, or a punch-through failure of the insulator holding off the cathode potential, as well as lesser though still serious problems. Various means to mitigate these problems are described. The operational lifetime of high quantum efficiency photocathodes in these guns is determined by the vacuum conditions, through phenomena such as chemical poisoning and ion back-bombardment. Minimization of the field strength on electrode structures pushes high-voltage DC guns toward large dimensions and, correspondingly, large outgassing loads, but it is also true that these guns offer many opportunities for achieving excellent vacuum conditions. Good solutions to vacuum problems that had previously limited cathode lifetime have been demonstrated in recent years. Designs for DC guns presently in use and planned for the near future will be described. The parameters necessary for a 100 mA average current, very-high-voltage DC gun with a photocathode operational lifetime greater than 100 h appear to be within reach, but have yet to be demonstrated. A 1 A average current source with good cathode operational lifetime will require developments beyond the present state-of-the-art

Phase formation in Na2MoO4 - MgMoO4 - Cr2(MoO4)3 system

International Nuclear Information System (INIS)

Kotova, I.Yu.; Kozhevnikova, N.M.

1998-01-01

Interaction within Na 2 MoO 4 - MgMoO 4 - Cr 2 (MoO 4 ) 3 ternary system is studied by X ray phase and DTA methods. State diagram of NaCr(MoO 4 ) 2 - MgMoO 4 section is plotted. Production of ternary molybdates of Na 1-x Mg 1-x Cr 1+x (MoO 4 ) 3 , where 0 ≤ x ≤ 0.3, and NaMg 3 Cr(MoO 4 ) 5 composition is ascertained [ru

Metabolic and Transcriptional Response to Cofactor Perturbations in Escherichia coli

DEFF Research Database (Denmark)

Holm, Anders Koefoed; Blank, L.M.; Oldiges, M.

2010-01-01

Metabolic cofactors such as NADH and ATP play important roles in a large number of cellular reactions, and it is of great interest to dissect the role of these cofactors in different aspects of metabolism. Toward this goal, we overexpressed NADH oxidase and the soluble F1-ATPase in Escherichia coli...... of redox and energy metabolism and should help in developing metabolic engineering strategies in E. coli....

RF gun using laser-triggered photocathode

International Nuclear Information System (INIS)

Akiyama, H.; Otake, Y.; Naito, T.; Takeuchi, Y.; Yoshioka, M.

1992-01-01

An RF gun using laser-triggered photocathode has many advantages as an injector of the linear colliders since it can generate a low emittance and high current pulsed beam. The experimental facility for the RF gun, such as an RF system, a laser system and a photocathode have been fabricated to study the fundamental characteristics. The dynamics of the RF gun has also studied by the 1D sheet beam model. (author)

Streptococcus sanguinis class Ib ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights.

Science.gov (United States)

Makhlynets, Olga; Boal, Amie K; Rhodes, Delacy V; Kitten, Todd; Rosenzweig, Amy C; Stubbe, JoAnne

2014-02-28

Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent studies demonstrate that this enzyme uses a dimanganese-tyrosyl radical (Mn(III)2-Y(•)) cofactor in vivo. The proteins required for S. sanguinis ribonucleotide reduction (NrdE and NrdF, α and β subunits of RNR; NrdH and TrxR, a glutaredoxin-like thioredoxin and a thioredoxin reductase; and NrdI, a flavodoxin essential for assembly of the RNR metallo-cofactor) have been identified and characterized. Apo-NrdF with Fe(II) and O2 can self-assemble a diferric-tyrosyl radical (Fe(III)2-Y(•)) cofactor (1.2 Y(•)/β2) and with the help of NrdI can assemble a Mn(III)2-Y(•) cofactor (0.9 Y(•)/β2). The activity of RNR with its endogenous reductants, NrdH and TrxR, is 5,000 and 1,500 units/mg for the Mn- and Fe-NrdFs (Fe-loaded NrdF), respectively. X-ray structures of S. sanguinis NrdIox and Mn(II)2-NrdF are reported and provide a possible rationale for the weak affinity (2.9 μM) between them. These streptococcal proteins form a structurally distinct subclass relative to other Ib proteins with unique features likely important in cluster assembly, including a long and negatively charged loop near the NrdI flavin and a bulky residue (Thr) at a constriction in the oxidant channel to the NrdI interface. These studies set the stage for identifying the active form of S. sanguinis class Ib RNR in an animal model for infective endocarditis and establishing whether the manganese requirement for pathogenesis is associated with RNR.

Green plasticizers for multibase gun propellants (Lecture)

NARCIS (Netherlands)

Schoolderman, C.; Driel, C.A. van; Zebregs, M.

2007-01-01

TNO Defence, Security and Safety has a long history of research on gun propellants. Areas investigated are formulating (new ingredients, optimization), manufacturing, charge design and lifetime assessment [1,2,3,4,5]. In conventional propellants inert plasticizers are used to alter performance,

Enzyme cofactors: Double-edged sword for catalysis

Science.gov (United States)

Ivanov, Ivaylo

2013-01-01

The metal cofactors responsible for the activity of CDK2 -- a representative member of the kinase superfamily of enzymes -- have now been shown to also have inhibitory effects during the catalytic cycle.

Design of the BEPCII electron gun system

International Nuclear Information System (INIS)

Liu Bo; Gu Mengping; Chi Yunlong

2006-01-01

BEPCII upgrading project needs a new high current electron gun. The design stage such as physical design, mechanical design and control system design of this new electron gun is described. The emission current is designed to be higher than 10 A for the pulse width of 1 ns with repetition rate of 50 Hz. The gun will operate with a pulsed high voltage power supply which can provide up to 200 kV high voltage. Computer simulations and optimizations have been carried out in the design stage, including the gun geometry and beam transport. EGUN and DGUN codes are used to simulate the gun geometry, and the results show that the perveance is about 0.22 μA·V -3/2 , and the emittance at gun exit is about 16 π·mm·mrad. PARMELA code shows that the electron beam can be easily transported to the end of the first accelerating tube with a capture efficiency of 67% and root mean square emittance of 25 mm·mrad. New scheme of the gun control system based on EPICS is also presented. Two-bunch operation mode and 2.5 μs long pulse operation mode are available in the control system. (authors)

Research on Miniature Calibre Rail-Guns for the Mechanical Arm

Directory of Open Access Journals (Sweden)

Ronggang Cao

2017-01-01

Full Text Available Rail-gun should not only be used to military applications, but also can be developed as applications in the civilian aspects of the market. With the development of the electromagnetic launch technology, based on the similarity theory, using the existing rail-gun model to guide the construction of more economical miniature calibre rail-guns, and apply it in some machinery and equipment, this idea will open up a wider rail-gun application space. This article will focus on the feasibility of application of miniature calibre rail-guns in the mechanical arm. This paper designs the schematic diagram, then theoretical analyzes force conditions of the armature in the mechanical arm, calculates the possible range of the current amplitude and so on. The existing rail-gun model can be used to guides design the circuit diagram of the miniature calibre rail-gun. Based on the similarity theory and many simulation experiments, designed the experimental parameters of a miniature rail-gun and analyzed the current, Lorentz force, velocity, and location of the existing rail-gun and miniature rail-gun. The results show that the rail-gun launching technology applied to robot arms is feasibility. The application of miniature calibre rail-guns in the mechanical arm will benefit to the further development of rail-guns.

Metabolic impact of redox cofactor perturbations in Saccharomyces cerevisiae

DEFF Research Database (Denmark)

Hou, Jin; Lages, Nuno; Oldiges, M.

2009-01-01

to induce widespread changes in metabolism. We present a detailed analysis of the impact of perturbations in redox cofactors in the cytosol or mitochondria on glucose and energy metabolism in Saccharomyces cerevisiae to aid metabolic engineering decisions that involve cofactor engineering. We enhanced NADH...... oxidation by introducing NADH oxidase or alternative oxidase, its ATP-mediated conversion to NADPH using NADH kinase as well as the interconversion of NADH and NADPH independent of ATP by the soluble, non-proton-translocating bacterial transhydrogenase. Decreasing cytosolic NADH level lowered glycerol...

The electron gun for the Daresbury SRS linac

International Nuclear Information System (INIS)

Dykes, D.M.

1996-01-01

The electron gun for the Daresbury SRS linac injector has been modified to use the cathode-grid assembly from the Eimac planar triode 8755. The gun now has improved beam characteristics, is more reliable and the cathode assembly is quicker and easier to change. This paper describes the assembly of the electron gun, and then the re-conditioning of the cathode highlighting the vacuum environment. The action of the grid modulation system on the electron beam, which pre-bunches the electron beam, is described, and typical gun characteristics are shown. Proposed developments to the gun system are discussed. (author)

Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation.

Science.gov (United States)

Su, Liqiu; Shen, Yanbing; Zhang, Wenkai; Gao, Tian; Shang, Zhihua; Wang, Min

2017-10-30

Cofactor engineering is involved in the modification of enzymes related to nicotinamide adenine dinucleotides (NADH and NAD + ) metabolism, which results in a significantly altered spectrum of metabolic products. Cofactor engineering plays an important role in metabolic engineering but is rarely reported in the sterols biotransformation process owing to its use of multi-catabolic enzymes, which promote multiple consecutive reactions. Androst-4-ene-3, 17-dione (AD) and androst-1, 4-diene-3, 17-dione (ADD) are important steroid medicine intermediates that are obtained via the nucleus oxidation and the side chain degradation of phytosterols by Mycobacterium. Given that the biotransformation from phytosterols to AD (D) is supposed to be a NAD + -dependent process, this work utilized cofactor engineering in Mycobacterium neoaurum and investigated the effect on cofactor and phytosterols metabolism. Through the addition of the coenzyme precursor of nicotinic acid in the phytosterols fermentation system, the intracellular NAD + /NADH ratio and the AD (D) production of M. neoaurum TCCC 11978 (MNR M3) were higher than in the control. Moreover, the NADH: flavin oxidoreductase was identified and was supposed to exert a positive effect on cofactor regulation and phytosterols metabolism pathways via comparative proteomic profiling of MNR cultured with and without phytosterols. In addition, the NADH: flavin oxidoreductase and a water-forming NADH oxidase from Lactobacillus brevis, were successfully overexpressed and heterologously expressed in MNR M3 to improve the intracellular ratio of NAD + /NADH. After 96 h of cultivation, the expression of these two enzymes in MNR M3 resulted in the decrease in intracellular NADH level (by 51 and 67%, respectively) and the increase in NAD + /NADH ratio (by 113 and 192%, respectively). Phytosterols bioconversion revealed that the conversion ratio of engineered stains was ultimately improved by 58 and 147%, respectively. The highest AD (D

Simulation of electron beam from two strip electron guns and control of power density by rotation of gun

International Nuclear Information System (INIS)

Sahu, G K; Baruah, S; Thakur, K B

2012-01-01

Electron beam is preferably used for large scale evaporation of refractory materials. Material evaporation from a long and narrow source providing a well collimated wedge shaped atomic beam has applications in isotopic purification of metals relevant to nuclear industry. The electron beam from an electron gun with strip type filament provides a linear heating source. However, the high power density of the electron beam can lead to turbulence of the melt pool and undesirable splashing of molten metal. For obtaining quiet surface evaporation, the linear electron beam is generally scanned along its length. To further reduce the power density to maintain quiet evaporation the width of the vapour source can be controlled by rotating the electron gun on its plane, thereby scanning an inclined beam over the molten pool. The rotation of gun has further advantages. When multiple strip type electron guns are used for scaling up evaporation length, a dark zone appears between two beams due to physical separation of adjacent guns. This dark zone can be reduced by rotating the gun and thereby bringing two adjacent beams closer. The paper presented here provides the simulation results of the electron beam trajectory and incident power density originating from two strip electron guns by using in-house developed code. The effect of electron gun rotation on the electron beam trajectory and power density is studied. The simulation result is experimentally verified with the image of molten pool and heat affected zone taken after experiment. This technique can be gainfully utilized in controlling the time averaged power density of the electron beam and obtaining quiet evaporation from the metal molten pool.

Mole gun injury.

Science.gov (United States)

Pistré, V; Rezzouk, J

2013-09-01

A mole gun is a weapon, which is used to trap and kill moles. This report provides an overview of the state of knowledge of mole gun injuries, comparable to blast injuries caused by fireworks, explosive or gunshot. Over a 2-year period, the authors reported their experience with ten hand injuries caused by mole gun. Radial side of the hand was often concerned, particularly the thumb. The authors explain their choices in the management of such lesions. Surgery was performed primarily and a large debridement currently seemed to offer the best outcome for the patient. Blast, crush, burns and lacerations may explain the higher rate of amputation to the digits. A long period of physiotherapy, specifically of the hand, was needed before the patient could return to work. This ballistic hand trauma encountered by surgeons requires knowledge and understanding of these injuries. It should be in accordance with firearms law because of severe injuries encountered and possible lethal wounds. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

78 FR 66840 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

Science.gov (United States)

2013-11-07

... Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION: Final rule. SUMMARY: Section 106 of the... regulations pertaining to caps intended for use with toy guns refer to obsolete equipment, but the ASTM F963...

Development of coaxial rotating-plasma gun

International Nuclear Information System (INIS)

Ikehata, Takashi; Tanabe, Toshio; Mase, Hiroshi

1985-01-01

A rotating-plasma gun has been devised to produce plasma streams with higher rotational velocities. The working mechanism of the gun and the results of a preliminary experiment have been described. (author)

Plural beam electron gun assembly

International Nuclear Information System (INIS)

Stratton, M.G.

1977-01-01

The invention relates to a cathode ray tube plural-beam-in-line bi-potential electron gun assembly, having applied beam currents of differing levels, manifests structurally modified gun structures to effect focused beam landings at the screen that are evidenced as substantially equi-sized spots thereby providing improved resolution and brightness of the screen imagery. The structural changes embody modifications of the related focusing and accelerator electrodes of the respective guns to provide a partial telescoping arrangement for effecting the discrete placement, forming and shielding of the final focusing lenses. The three lenses so formed are in different planes in partial overlapping axial relationship

Brief use of a specific gun in a violent game does not affect attitudes towards that gun

OpenAIRE

Hilgard, Joseph; Engelhardt, Christopher R.; Bartholow, Bruce D.

2016-01-01

Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) ...

Gun ownership and firearm-related deaths.

Science.gov (United States)

Bangalore, Sripal; Messerli, Franz H

2013-10-01

A variety of claims about possible associations between gun ownership rates, mental illness burden, and the risk of firearm-related deaths have been put forward. However, systematic data on this issue among various countries remain scant. Our objective was to assess whether the popular notion "guns make a nation safer" has any merits. Data on gun ownership were obtained from the Small Arms Survey, and for firearm-related deaths from a European detailed mortality database (World Health Organization), the National Center for Health Statistics, and others. Crime rate was used as an indicator of safety of the nation and was obtained from the United Nations Surveys of Crime Trends. Age-standardized disability-adjusted life-year rates due to major depressive disorder per 100,000 inhabitants with data obtained from the World Health Organization database were used as a putative indicator for mental illness burden in a given country. Among the 27 developed countries, there was a significant positive correlation between guns per capita per country and the rate of firearm-related deaths (r = 0.80; P ownership and mental illness as independent covariates, gun ownership was a significant predictor (P <.0001) of firearm-related deaths, whereas mental illness was of borderline significance (P = .05) only. The number of guns per capita per country was a strong and independent predictor of firearm-related death in a given country, whereas the predictive power of the mental illness burden was of borderline significance in a multivariable model. Regardless of exact cause and effect, however, the current study debunks the widely quoted hypothesis that guns make a nation safer. Copyright © 2013 Elsevier Inc. All rights reserved.

Redox cofactor engineering in industrial microorganisms: strategies, recent applications and future directions.

Science.gov (United States)

Liu, Jiaheng; Li, Huiling; Zhao, Guangrong; Caiyin, Qinggele; Qiao, Jianjun

2018-05-01

NAD and NADP, a pivotal class of cofactors, which function as essential electron donors or acceptors in all biological organisms, drive considerable catabolic and anabolic reactions. Furthermore, they play critical roles in maintaining intracellular redox homeostasis. However, many metabolic engineering efforts in industrial microorganisms towards modification or introduction of metabolic pathways, especially those involving consumption, generation or transformation of NAD/NADP, often induce fluctuations in redox state, which dramatically impede cellular metabolism, resulting in decreased growth performance and biosynthetic capacity. Here, we comprehensively review the cofactor engineering strategies for solving the problematic redox imbalance in metabolism modification, as well as their features, suitabilities and recent applications. Some representative examples of in vitro biocatalysis are also described. In addition, we briefly discuss how tools and methods from the field of synthetic biology can be applied for cofactor engineering. Finally, future directions and challenges for development of cofactor redox engineering are presented.

Ion plasma electron gun

International Nuclear Information System (INIS)

Wakalopulos, G.

1976-01-01

In the disclosed electron gun positive ions generated by a hollow cathode plasma discharge in a first chamber are accelerated through control and shield grids into a second chamber containing a high voltage cold cathode. These positive ions bombard a surface of the cathode causing the cathode to emit secondary electrons which form an electron beam having a distribution adjacent to the cathode emissive surface substantially the same as the distribution of the ion beam impinging upon the cathode. After passing through the grids and the plasma discharge chamber, the electron beam exits from the electron gun via a foil window. Control of the generated electron beam is achieved by applying a relatively low control voltage between the control grid and the electron gun housing (which resides at ground potential) to control the density of the positive ions bombarding the cathode

Association Between Gambling and Exposure to Guns Among Cocaine-Using Women.

Science.gov (United States)

Vaddiparti, Krishna; Striley, Catherine W; Cottler, Linda B

2016-09-01

The purpose of this study is to assess the association between gambling severity and exposure to guns among substance-using women recruited in the community. Data for these analyses come from the baseline phase of two community-based HIV prevention interventions conducted among alcohol and drug-using women in St. Louis, MO. Gun exposure was assessed using the Violence Exposure Questionnaire (VEQ), and DSM-IV pathological gambling (PG) symptoms and other psychiatric symptoms were assessed using the Computerized Diagnostic Interview Schedule; The Composite International Diagnostic Interview Substance Abuse Module assessed DSM-IV substance dependence, including cocaine dependence and alcohol dependence. Women in the study were predominantly African American (80%), mean age was 35.70 years ±8.8. Women exposed to guns were significantly more likely than women not exposed to guns to have gambled with all consequences: without meeting PG criteria (21% vs. 15%); to meet 1 to 4 PG criteria (22% vs. 12%), and to report 5 or more PG criteria (10% vs. 5%). These differences were significant at p  gambled without PG symptoms (OR = 1.77; 95% CI = 1.10-2.85) were nearly twice more likely to have exposure to guns than women who did not gamble. The risk for gun exposure increased with severity of gambling. Women who gambled and reported one to four PG criteria were twice as likely to have had an exposure to guns (OR 2.04; 95% CI = 1.45-3.06) and this risk increased to nearly threefold among women who met five or more criteria of PG (OR 2.65; 95% CI = 1.32-5.32). In addition, endorsing five or more criteria for major depressive disorder (OR 1.44; 95% CI = 1.00-2.06) and three or more criteria for antisocial personality adult criteria (OR 3.78; 95% CI = 2.03-7.02) were strong predictors for gun exposure among these women. The findings indicate that substance-using women with gambling behavior are at an enhanced risk to have exposure to guns.

SSRL photocathode RF gun test stand

International Nuclear Information System (INIS)

Hernandez, M.; Baltay, M.; Boyce, A.

1995-01-01

A photocathode RF gun test stand designed for the production and study of high brightness electron beams will be constructed at SSRL. The beam will be generated from a laser driven third generation photocathode RF gun being developed in collaboration with BNL, LBL, and UCLA. The 3-5 [MeV] beam from the gun will be accelerated using a SLAC three meter S-band accelerator section, in order to achieve the desired low emittance beam, emittance compensation with solenoidal focusing will be employed

Patterns of gun deaths across US counties 1999-2013.

Science.gov (United States)

Kalesan, Bindu; Galea, Sandro

2017-05-01

We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (WONDER). We characterized four levels of gun violence, as distinct levels of gun death rates of relatively safe, unsafe, violent, and extremely violent counties, based on quartiles of 15-year county-specific gun death rates per 100,000 and used negative binomial regression models allowing clustering by state to calculate incidence rate ratios and 95% confidence intervals (95% CIs). Most states had at least one violent or extremely violent county. Extremely violent gun counties were mostly rural, poor, predominantly minority, had high unemployment rate and homicide rate. Overall, homicide rate was significantly associated with gun deaths (incidence rate ratios = 1.08, 95% CI = 1.06-1.09). In relatively safe counties, this risk was 1.09 (95% CI = 1.05-1.13) and in extremely violent gun counties was 1.03 (95% CI = 1.03-1.04). There are broad differences in gun death rates across the United States representing different levels of gun death rates in each state with distinct socio-demographic profiles. Copyright © 2017 Elsevier Inc. All rights reserved.

Generation of femtosecond electron single pulse using laser photocathode RF gun

Energy Technology Data Exchange (ETDEWEB)

Uesaka, M.; Kinoshita, K.; Watanabe, T. [Nuclear Engineering Research Laboratory, University of Tokyo, Tokai, Ibaraki (JP)] [and others

1998-11-01

A new laser photocathode RF electron gun was installed in the second linac of the S-band twin linac system of Nuclear Engineering Research Laboratory(NERL) of University of Tokyo in August in 1997. Since then, the behavior of the new gun has been tested and the characteristic parameters have been evaluated. At the exit of the gun, the energy is 4.7 MeV, the charge per bunch 1 nC, the pulse width is 10 ps(FWHM), respectively, for 6 MW RF power supply from a klystron. The electron bunch is accelerated up to 17 MeV. The horizontal normalized emittance is 1 {pi} mm.mrad. Then, the bunch is compressed to be 440 fs(FWHM) with 0.35 nC by the chicane-type magnetic pulse compressor. The gun is planned to be used for femtosecond X-ray generation via the head-on Thomson scattering and laser wakefield acceleration in 1998. (author)

Status and future prospects of SRF gun developments

International Nuclear Information System (INIS)

Teichert, Jochen

2006-01-01

While the concepts of DC and normal-conducting photo-injectors are well proofed, the SRF gun development still possesses a high risk. Challenges are the thermal and contaminant isolation needed between the cathode and superconducting cavity, the choice of the right photocathode and its life time, the difficulty of coupling high-average power into the gun, and beam excitation of higher order cavity modes. But in combination with SRF linacs, the SRF guns are the best solution for high current and CW operation. Thus, several R and D projects of SRF gun have been launched. The talk will give an overview of the history and progress of the SRF gun development. In more detail the technical concept, performance, and status of the Rossendorf superconducting RF gun project, a collaboration of BESSY, DESY, MBI and FZR, will be presented. (author)

Design of a high repetition rate S-band photocathode gun

International Nuclear Information System (INIS)

Han Janghui; Cox, Matthew; Huang, Houcheng; Pande, Shivaji

2011-01-01

Photocathode RF guns have been developed in many laboratories for generating high quality electron beams for free-electron lasers based on linear accelerators. Such guns can generate electron beams with an exceptionally high peak current as well as a small transverse emittance. Their applications have been recently expanded for ultrafast electron diffraction, coherent terahertz radiation, and X-ray or γ-ray radiation by Compton scattering. In this paper, we design an S-band normal-conducting gun with capabilities of high quality beam generation and high repetition rate operation. The RF design and thermal analysis of the gun cavity and coupler are introduced. Optimal position of the gun focusing solenoid for low emittance beam generation is found by performing particle tracking simulations. Then, the gun system is designed to be able to afford the optimal solenoid position. The cooling-water channel surrounding the gun cavity and coupler is designed and analyzed numerically. The pressure in the gun is simulated with a vacuum model containing the detailed inner structure of the gun. An injector for a free-electron laser application is designed by using this gun and the beam dynamics simulation is shown. A cold test with a prototype gun for confirmation of the RF design is reported. - Highlights: → We design an S-band gun for low emittance beam generation and high repetition rate operation. → The RF design and thermal analysis of the gun cavity and coupler are studied. → An FEL injector is designed by using this gun and the beam dynamics simulation is shown. → A cold test with a prototype gun for confirmation of the RF design is reported.

Acute Alcohol Consumption, Alcohol Outlets, and Gun Suicide

Science.gov (United States)

Branas, Charles C.; Richmond, Therese S.; Ten Have, Thomas R.; Wiebe, Douglas J.

2014-01-01

A case–control study of 149 intentionally self-inflicted gun injury cases (including completed gun suicides) and 302 population-based controls was conducted from 2003 to 2006 in a major US city. Two focal independent variables, acute alcohol consumption and alcohol outlet availability, were measured. Conditional logistic regression was adjusted for confounding variables. Gun suicide risk to individuals in areas of high alcohol outlet availability was less than the gun suicide risk they incurred from acute alcohol consumption, especially to excess. This corroborates prior work but also uncovers new information about the relationships between acute alcohol consumption, alcohol outlets, and gun suicide. Study limitations and implications are discussed. PMID:21929327

Production of thermoluminescent dosemeters based on MgB{sub 4}O{sub 7}: Dy and MgB{sub 4}O{sub 7}: Tm; Producao de dosimetros termoluminescentes a base de MgB{sub 4}O{sub 7}: Dy e MgB{sub 4}O{sub 7}: Tm

Energy Technology Data Exchange (ETDEWEB)

Souza, Luiza Freire de; Souza, Divanizia N., E-mail: luizaf25@hotmail.com, E-mail: divanizi@ufs.br [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Programa de Pos-Graduacao em Fisica

2013-07-01

The thermoluminescent dosimetry (TL) is a well-established technique for the detection of ionizing radiation in hospitals, clinics, and industrial establishments where there is the need to quantify the radiation. For this practice is require the use phosphors which are sensitive to radiation. Some phosphors are already commonly used in this practice, for example, TLD-100 (LiF: Mg, Ti), CaSO{sub 4}:Tm and CaSO{sub 4}:Dy. A compound that was most recently introduced in dosimetry and has many advantageous features to detect neutrons, electrons and gamma is the magnesium tetraborate (MgB{sub 4}O{sub 7}), but the undoped material is not good for dosimetry, since signal does not show satisfactory thermoluminescence. The present work presents the analysis of the compound MgB{sub 4}O{sub 7} when doped with rare earth elements, thulium (Tm) and dysprosium (Dy). The production of MgB{sub 4}O{sub 7}: Dy and MgB{sub 4}O{sub 7}: Tm occurred under acidic conditions. Following the process of crystal growth, several tests were made on phosphors produced to verify the quality of materials as TL dosimeter. Initially, was made the identification of the crystalline phases found in the material, using the technique of X-ray diffractometry, and then were evaluated and compared the TL emission curves of the crystals with two different types of dopants, to this, the samples were irradiated with different radiation sources: {sup 137}Cs (0,66 MeV), {sup 60}Co (1.25 MeV) and X-rays (0.41 MeV) and based on the results was evaluated the energy dependence of phosphors. Another characteristic analyzed, was the decay of TL signal for the material (fading). The results show that the material can be an excellent TL dosimeter when doped with rare earth elements Dy and Tm. (author)

Separating Batterers and Guns: A Review and Analysis of Gun Removal Laws in 50 States

Science.gov (United States)

Frattaroli, Shannon; Vernick, Jon S.

2006-01-01

Firearms play an important role in lethal domestic violence incidents. The authors review state laws regarding two policies to separate batterers from firearms: laws authorizing police to remove firearms when responding to a domestic violence complaint ("police gun removal laws") and laws authorizing courts to order guns removed from batterers…

Study of Control Grid Thermionic Cathode RF Gun

CERN Document Server

Xiao, Jin; Ming, Li; Xinfan, Yang; Xumin, Shen; Yanan, Chen; Zhou, Xu

2004-01-01

In this paper, the beam loading effect of RF Gun was analyzed. To minimize the energy spread, the grid control RF Gun was introduced. The result shows that the grid congrol RF Gun can increase electron beam within 1% energy spread.

Klystron - Space-charge limited flow, guns, Perveance

International Nuclear Information System (INIS)

Isagawa, S.

1999-01-01

This paper treats Thermionic emission, Cathode as an e - emitter, Space-charge limited effect and 3/2 power law, Perveance, Beam spread due to space charge, Pierce guns, Magnetically immersed guns, Method of gun design including simulations, and Examples, mainly treating E3786, which attendees will operate above 1 MW-CW in a practical exercise course at KEK. (author). 74 refs

Gunning for accuracy: Company targets human error with 'foolproof' perforating gun

Energy Technology Data Exchange (ETDEWEB)

Ross, E.

2002-12-01

An innovative new design for a scalloped expandable perforating gun is described. The gun is manufactured in Edmonton by LRI Perforating Systems, and it aimed at reducing the chances of human error that can result in sub-optimal performance. A perforating gun is used to pierce the well's casing to allow hydrocarbons to flow into the wellbore. It consists of a carrier, a pipe with an eighth-inch thick wall that protects the explosives downhole, and an inner tube containing the explosives. The LRI system has a unique interlocking mechanism for the end plates, which are attached to either end of the thin-walled charge holder tube, in addition to other advantageous features, including a price advantage of 10 to 15 per cent. Marketing strategy is designed to interest wi reline companies that focus on vertical well applications. 1 photo.

Characteristics of the ETA gun

International Nuclear Information System (INIS)

Paul, A.C.; Neil, V.K.; Craig, G.D.; Fessenden, T.J.

1981-01-01

The Experimental Test Accelerator (ETA) is a linear induction device consisting of a 2.5-MV electron gun and ten 0.25-MV accelerating units designed to produce a 10-kA beam of electrons at 5 MeV. Calculations with the computer code EBQ as well as experimental measurements indicate that the current produced by the gun is limited by two phenomena. The first arises from the variation of particle energy with time during the pulse. Only particles with energy within a limited range can be transported by the focusing coils in the gun: therefore the variation of the gun's output current with time is determined by the coil settings. The second effect results from a collective interaction at sufficiently large current to cause a virtual cathode to form a few centimeters past the extraction grid. Operation in this regime results in greatly increased beam emittance and poor beam transport through the accelerator. Results of the code calculations are compared with experimental data and found to be in good agreement. (author)

Superconducting augmented rail gun (SARG)

International Nuclear Information System (INIS)

Homan, C.G.; Cummings, C.E.; Fowler, C.M.

1986-01-01

Superconducting augmentation consists of a superconducting coil operating in the persistent mode closely coupled magnetically with a normally conducting rail gun. A theoretical investigation of the effect of this system on a rail gun has shown that two benefits occur. Projectile velocities and launch efficiencies increase significantly depending on the magnetic coupling between the rail and augmentation circuits. Previous work evaluated an idealized system by neglecting energy dissipation effects. In this paper, the authors extend the analysis to include the neglected terms and show improved actual launch efficiencies for the SARG configuration. In this paper, the authors discuss details of projectile design in depth and present preliminary results of rail gun performance

Cerebral damage caused by nail gun injury

DEFF Research Database (Denmark)

Andersen, Chris

2016-01-01

Background Accidents with nail guns are rather common, especially in the construction industry. Most injuries involve the extremities and several present with intracerebral injuries. When the patient is unconscious, it can be a big challenge to determine whether the injury is an accident, self....... The forensic examination showed lesions of intracranial surgery and minor bruises on the arms. No sign of defense injuries was found. There were no signs of malfunction of the nail gun-wielding robot. On the side of the machine, there were a handheld nail gun and the police investigated the case as a possible...... criminal act. They found bloodstains on the back of the machine. When awake, the man explained, that by accident, he had hit his head against a nail gun and as a result of this, the nail gun delivered a nail into his skull. Conclusion Sometimes, the circumstances of a case are not clear...

Geometry Optimization of DC/RF Photoelectron Gun

CERN Document Server

Chen Ping; Yu, David

2005-01-01

Pre-acceleration of photoelectrons in a pulsed, high voltage, short, dc gap and its subsequent injection into an rf gun is a promising method to improve electron beam emittance in rf accelerators. Simulation work has been performed in order to optimize the geometric shapes of a dc/rf gun and improve electron beam properties. Variations were made on cathode and anode shapes, dc gap distance, and inlet shape of the rf cavity. Simulations showed that significant improvement on the normalized emittance (< 1 mm-mrad), compared to a dc gun with flat cathode, could be obtained after the geometric shapes of the gun were optimized.

NASA-Ames vertical gun

Science.gov (United States)

Schultz, P. H.

1984-01-01

A national facility, the NASA-Ames vertical gun range (AVGR) has an excellent reputation for revealing fundamental aspects of impact cratering that provide important constraints for planetary processes. The current logistics in accessing the AVGR, some of the past and ongoing experimental programs and their relevance, and the future role of this facility in planetary studies are reviewed. Publications resulting from experiments with the gun (1979 to 1984) are listed as well as the researchers and subjects studied.

ATA injector-gun calculations

International Nuclear Information System (INIS)

Paul, A.C.

1981-01-01

ATA is a pulsed, 50 ns 10 KA, 50 MeV linear induction electron accelerator at LLNL. The ETA could be used as an injector for ATA. However the possibility of building a new injector gun for ATA, raised the question as to what changes from the ETA gun in electrode dimensions or potentials, if any, should be considered. In this report the EBQ code results for the four electrode configurations are reviewed and an attempt is made to determine the geometrical scaling laws appropriate to these ETA type gun geometries. Comparison of these scaling laws will be made to ETA operation. The characteristic operating curves for these geometries will also be presented and the effect of washer position determined. It will be shown that emittance growth will impose a limitation on beam current for a given anode potential before the virtual cathode limit is reached

ECR ion source with electron gun

Science.gov (United States)

Xie, Zu Q.; Lyneis, Claude M.

1993-01-01

An Advanced Electron Cyclotron Resonance ion source (10) having an electron gun (52) for introducing electrons into the plasma chamber (18) of the ion source (10). The ion source (10) has a injection enclosure (12) and a plasma chamber tank (14). The plasma chamber (18) is defined by a plurality of longitudinal magnets (16). The electron gun (52) injects electrons axially into the plasma chamber (18) such that ionization within the plasma chamber (18) occurs in the presence of the additional electrons produced by the electron gun (52). The electron gun (52) has a cathode (116) for emitting electrons therefrom which is heated by current supplied from an AC power supply (96) while bias potential is provided by a bias power supply (118). A concentric inner conductor (60) and Outer conductor (62) carry heating current to a carbon chuck (104) and carbon pusher (114) Which hold the cathode (116) in place and also heat the cathode (16). In the Advanced Electron Cyclotron Resonance ion source (10), the electron gun (52) replaces the conventional first stage used in prior art electron cyclotron resonance ion generators.

Revised theory of Pierce-type electron guns

International Nuclear Information System (INIS)

Sar-El, H.Z.

1982-01-01

Attempts to date to obtain the shape of the beam forming electrodes of various Pierce-type electron guns are briefly discussed with emphasis on the many discrepansis in the results of previous works. A revised theory of Pierce-type electron guns is proposed. The shapes of the beam-forming electrodes for all known configurations of Pierce guns were computed on the basis of the proposed theory. (orig.)

Gas injected washer plasma gun

International Nuclear Information System (INIS)

Jain, K.K.; John, P.I.; Punithavelu, A.M.; Rao, P.P.

1980-01-01

A plasma gun similar in geometry to the washer plasma gun has been operated with gas injected externally. hydrogen, nitrogen and argon plasmas have been ionised and accelerated to velocities of the order of 10 7 mm s -1 and densities 10 11 mm -3 . Higher parameter range is possible with higher electrical input power. (author)

Gun Concerns Personal for Duncan

Science.gov (United States)

McNeil, Michele

2013-01-01

As U.S. Secretary of Education Arne Duncan works with other Obama administration officials on policy responses to the shootings at a Connecticut elementary school, he brings a personal and professional history that has acquainted him with the impact of gun violence. As schools chief in Chicago from 2001 to 2008, he was affected by the gun deaths…

Gun Safety Management with Patients at Risk for Suicide

Science.gov (United States)

Simon, Robert I.

2007-01-01

Guns in the home are associated with a five-fold increase in suicide. All patients at risk for suicide must be asked if guns are available at home or easily accessible elsewhere, or if they have intent to buy or purchase a gun. Gun safety management requires a collaborative team approach including the clinician, patient, and designated person…

MgB2 magnetometer with directly coupled pick-up loop

NARCIS (Netherlands)

Portesi, C.; Mijatovic, D.; Veldhuis, Dick; Brinkman, Alexander; Monticone, E.; Gonnelli, R.S.

2006-01-01

magnetometer with a directly coupled pick-up loop. We used an all in situ technique for fabricating magnesium diboride films, which consists of the co-evaporation of B and Mg by means of an e-gun and a resistive heater respectively. Consequently, we realized the superconducting device, which

Engineering cofactor flexibility enhanced 2,3-butanediol production in Escherichia coli.

Science.gov (United States)

Liang, Keming; Shen, Claire R

2017-12-01

Enzymatic reduction of acetoin into 2,3-butanediol (2,3-BD) typically requires the reduced nicotinamide adenine dinucleotide (NADH) or its phosphate form (NADPH) as electron donor. Efficiency of 2,3-BD biosynthesis, therefore, is heavily influenced by the enzyme specificity and the cofactor availability which varies dynamically. This work describes the engineering of cofactor flexibility for 2,3-BD production by simultaneous overexpression of an NADH-dependent 2,3-BD dehydrogenase from Klebsiella pneumoniae (KpBudC) and an NADPH-specific 2,3-BD dehydrogenase from Clostridium beijerinckii (CbAdh). Co-expression of KpBudC and CbAdh not only enabled condition versatility for 2,3-BD synthesis via flexible utilization of cofactors, but also improved production stereo-specificity of 2,3-BD without accumulation of acetoin. With optimization of medium and fermentation condition, the co-expression strain produced 92 g/L of 2,3-BD in 56 h with 90% stereo-purity for (R,R)-isoform and 85% of maximum theoretical yield. Incorporating cofactor flexibility into the design principle should benefit production of bio-based chemical involving redox reactions.

Design of a Two-Stage Light Gas Gun for Muzzle Velocities of 10 - 11 kms

Science.gov (United States)

Bogdanoff, David W.

2016-01-01

Space debris poses a major risk to spacecraft. In low earth orbit, impact velocities can be 10 11 kms and as high as 15 kms. For debris shield design, it would be desirable to be able to launch controlled shape projectiles to these velocities. The design of the proposed 10 11 kmsec gun uses, as a starting point, the Ames 1.280.22 two stage gun, which has achieved muzzle velocities of 10 11.3 kmsec. That gun is scaled up to a 0.3125 launch tube diameter. The gun is then optimized with respect to maximum pressures by varying the pump tube length to diameter ratio (LD), the piston mass and the hydrogen pressure. A pump tube LD of 36.4 is selected giving the best overall performance. Piezometric ratios for the optimized guns are found to be 2.3, much more favorable than for more traditional two stage light gas guns, which range from 4 to 6. The maximum powder chamber pressures are 20 to 30 ksi. To reduce maximum pressures, the desirable range of the included angle of the cone of the high pressure coupling is found to be 7.3 to 14.6 degrees. Lowering the break valve rupture pressure is found to lower the maximum projectile base pressure, but to raise the maximum gun pressure. For the optimized gun with a pump tube LD of 36.4, increasing the muzzle velocity by decreasing the projectile mass and increasing the powder loads is studied. It appears that saboted spheres could be launched to 10.25 and possibly as high as 10.7 10.8 kmsec, and that disc-like plastic models could be launched to 11.05 kms. The use of a tantalum liner to greatly reduce bore erosion and increase muzzle velocity is discussed. With a tantalum liner, CFD code calculations predict muzzle velocities as high as 12 to 13 kms.

Performance of a carbon nanotube field emission electron gun

Science.gov (United States)

Getty, Stephanie A.; King, Todd T.; Bis, Rachael A.; Jones, Hollis H.; Herrero, Federico; Lynch, Bernard A.; Roman, Patrick; Mahaffy, Paul

2007-04-01

A cold cathode field emission electron gun (e-gun) based on a patterned carbon nanotube (CNT) film has been fabricated for use in a miniaturized reflectron time-of-flight mass spectrometer (RTOF MS), with future applications in other charged particle spectrometers, and performance of the CNT e-gun has been evaluated. A thermionic electron gun has also been fabricated and evaluated in parallel and its performance is used as a benchmark in the evaluation of our CNT e-gun. Implications for future improvements and integration into the RTOF MS are discussed.

Law Enforcement and Gun Retailers as Partners for Safely Storing Guns to Prevent Suicide: A Study in 8 Mountain West States.

Science.gov (United States)

Runyan, Carol W; Brooks-Russell, Ashley; Brandspigel, Sara; Betz, Marian; Tung, Gregory; Novins, Douglas; Agans, Robert

2017-11-01

To examine the extent to which law enforcement agencies (LEAs) and gun retailers are willing to offer voluntary, temporary storage as a part of an overall suicide prevention effort. We invited all LEAs and gun retailers in 8 US states to respond to questionnaires asking about their willingness to offer temporary gun storage and their recommendations to gun owners about safe storage. We collected data in 2016 from 448 LEAs and 95 retailers (response rates of 53% and 25%, respectively). Three quarters of LEAs (74.8%; 95% confidence interval [CI] = 72.1, 77.5) indicated they already provided temporary storage compared with 47.6% (95% CI = 39.2, 56.0) of retailers. LEAs were most willing to provide storage when a gun owner was concerned about the mental health of a family member. Retailers were more receptive than were LEAs to providing storage when visitors were coming or for people wanting storage while traveling. Both groups recommended locking devices within the home, but LEAs were slightly more favorable to storing guns away from the home. Law enforcement agencies and gun retailers are important resources for families concerned about suicide.

Trapping of gun-injected plasma by a tokamak

International Nuclear Information System (INIS)

Leonard, A.W.; Dexter, R.N.; Sprott, J.C.

1986-01-01

It is shown that a plasma produced by a Marshall gun can be injected into and trapped by a tokamak plasma. Gun injection raises the line-averaged density and peaks the density profile. Trapping of the gun-injected plasma is explainable in terms of a depolarization current mechanism

doped LiMgPO4 phosphor

Indian Academy of Sciences (India)

attention because of their remarkable luminescence proper- ties and .... Figure 1. (a) X-ray diffraction patterns of LiMgPO4:Tb3+ phosphor and (b) standard data. ICDD file. .... ground signal which affects the signal to noise ratio [17]. MDD was ...

High Brightness Injectors Based On Photocathode DC Gun

International Nuclear Information System (INIS)

B. Yunn

2001-01-01

Sample results of new injector design method based on a photocathode dc gun are presented, based on other work analytically proving the validity of the emittance compensation scheme for the case even when beam bunching is involved. We have designed several new injectors appropriate for different bunch charge ranges accordingly. Excellent beam quality produced by these injectors clearly shows that a photocathode dc gun can compete with a rf gun on an equal footing as the source of an electron beam for the bunch charge ranging up to 2 nano Coulomb (nC). This work therefore elevates a dc gun based injector to the preferred choice for many ongoing high brightness accelerator projects considering the proven operational stability and high average power capability of the dc gun

Interaction in the NaIn(MoO4)2 - AMoO4 (A = Mg, Mn) systems

International Nuclear Information System (INIS)

Kotova, I.Yu.; Kozhevnikova, N.M.

2001-01-01

The results of investigation into NaIn(MoO 4 ) 2 - AMoO 4 (A = Mg, Mn) quasibinary cross-sections by means of X-ray diffraction and differential thermal analysis are presented. Conducted researches revealed that compounds NaMg 3 In(MoO 4 ) and NaMn 3 In(MoO 4 ) melting incongruently at 990 Deg C and 940 Deg C accordingly were formed in the NaIn(MoO 4 ) - AMoO 4 (A = Mg, Mn) systems. The data of initiation of X-ray diffraction pattern of NaMg 3 In(MoO 4 ) 5 are presented. The temperature dependences of conductivity, dielectric permeability and tangent of dielectric losses indicative on ionic-electronic nature conductivity are determined. Activation energy of conductivity in the Mg - Mn row changes moderately - from 9.91 till 5.71 eV [ru

PHERMEX electron gun development

International Nuclear Information System (INIS)

Builta, L.A.; Elliott, J.C.; Moir, D.C.; Starke, T.P.; Vecere, C.A.

1983-01-01

The PHERMEX facility is a 50-MHz standing-wave linear accelerator. Electrons are injected, accelerated, and transported to a tungsten target where bremsstrahlung x rays are generated for flash radiography of hydrodynamic systems. The purpose of this article is to describe the progress of PHERMEX electron gun development. The goal of this program is to generate and transport a 200-ns, 1-MV, 1-kA electron beam into the first PHERMEX accelerating cavity. The standard gun is operated at a pulse voltage of 550 kV, which is the limit determined by internal breakdown of the vacuum insulator. This insulator has been redesigned, and the gun has been pulsed at 750 kV without internal breakdown. At present, the current output is not limited by voltage but by a phenomenon called pulse shortening, which occurs at a pulse voltage of approximately 650 kV. The phenomenon has been investigated and the results are presented

What is the level of household gun ownership in urban Mexico? An estimate from the first Mexican survey on gun ownership 2017.

Science.gov (United States)

Perez Esparza, David; Hemenway, David

2017-12-20

Gun violence has increased in Mexico since the mid-2000s, but little is known about patterns of gun ownership. We examine the size and composition of the privately held urban firearm stock in Mexico, motivations for ownership, and attitudes about gun laws. To this end, a household telephone survey of 1361 adults living in nine Mexican cities was conducted in the summer of 2017. We find that few urban Mexican households contain guns. Most of those who report ownership possess one gun, having purchased it recently for self-defense. Few urban Mexican citizens plan to purchase a gun in the future. Respondents are more likely to believe that crime in Mexico would increase if guns were allowed in more places (ie, workplaces and motor vehicles). Evidence suggests urban Mexico has relative low rates of firearm ownership. Few city dwellers plan on obtaining a firearm in the near future. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Electrothermal plasma gun as a pellet injector

International Nuclear Information System (INIS)

Kincaid, R.W.; Bourham, M.A.

1994-01-01

The NCSU electrothermal plasma gun SIRENS has been used to accelerate plastic (Lexan polycarbonate) pellets, to determine the feasibility of the use of electrothermal guns as pellet injectors. The use of an electrothermal gun to inject frozen hydrogenic pellets requires a mechanism to provide protective shells (sabots) for shielding the pellet from ablation during acceleration into and through the barrel of the gun. The gun has been modified to accommodate acceleration of the plastic pellets using special acceleration barrels equipped with diagnostics for velocity and position of the pellet, and targets to absorb the pellet's energy on impact. The length of the acceleration path could be varied between 15 and 45 cm. The discharge energy of the electrothermal gun ranged from 2 to 6 kJ. The pellet velocities have been measured via a set of break wires. Pellet masses were varied between 0.5 and 1.0 grams. Preliminary results on 0.5 and 1.0 g pellets show that the exit velocity reaches 0.9 km/s at 6 kJ input energy to the source. Higher velocities of 1.5 and 2.7 km/s have been achieved using 0.5 and 1.0 gm pellets in 30 cm long barrel, without cleaning the barrel between the shots

78 FR 11902 - Review of Gun Safety Technologies

Science.gov (United States)

2013-02-20

... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (NIJ) Docket No. 1615] Review of Gun Safety...'s Plan to reduce gun violence released on January 16, 2013, the U.S. Department of Justice, Office... emerging gun safety technologies and plans to issue a report on the availability and use of those...

Gun Access and Safety Practices among Older Adults

Directory of Open Access Journals (Sweden)

Hillary D. Lum

2016-01-01

Full Text Available Background. Given high rates of gun ownership among older adults, geriatric providers can assess firearm safety practices using a “5 Ls” approach: Locked; Loaded; Little children; feeling Low; and Learned owner. This study describes gun access and the “5 Ls” among US older adults. Methods. Data on the “5 Ls” from the Second Injury Control and Risk Survey (ICARIS-2, a national telephone survey conducted by the Centers for Disease Control and Prevention, were analyzed. Weighted variables were used to generate national estimates regarding prevalence of gun ownership and associated gun safety among older adults (≥55 years. Results. Of 2939 older adults, 39% (95% CI 37%–42% reported ≥1 gun stored at home. Among those with guns at home, 21% (95% CI 18–24% stored guns loaded and unlocked; 9.2% (95% CI 6.6–12% had ≥1 child in household; 5.1% (95% CI 3.5–6.8% reported past-year suicidal ideation and 3.6% (95% CI 2.1–5.2% reported history of a suicide attempt; and 55% (95% CI 51–59% stated that ≥1 adult had attended firearm safety workshop. Conclusion. Some older adults may be at elevated risk of firearm injury because of storage practices, suicidal thoughts, or limited safety training. Future work should assess effective approaches to reduce the risk of gun-related injuries among older adults.

A 3 GHz photoelectron gun for high beam intensity

CERN Document Server

Bossart, Rudolf; Dehler, M; Godot, J C

1996-01-01

For the Compact Linear Collider Test Facility (CTF) at CERN a new rf gun with a laser driven photocathode is under construction. The new rf gun will replace the present 11/2 cell gun and will consist of 21/2 cells accelerating the beam to a momentum of 7.0 MeV/c with an electric field strength of 100 MV/m. The strong space-charge forces at low beam energy caused by the high charge density of the electron bunches are contained by radial and longitudinal rf focusing in the gun. The rf gun under construction has been optimized by MAFIA beam simulations for an injector assembly comprising a second accelerating rf structure and an intermediate solenoid magnet correcting the beam divergence of the 21/2 cell gun. The beam loading of the rf gun, by a train of 48 bunches with 21 nC charge each, causes a strong energy decay accompanied by an increase of the flight time for the bunches with lower energy. These effects can be corrected by slightly shifting the acceleration frequency of the gun. The experimental results...

Utility of indices of gun availability in the community.

Science.gov (United States)

Shenassa, Edmond D; Daskalakis, Constantine; Buka, Stephen L

2006-01-01

To estimate the degree to which the proportion of homicides and suicides committed with a gun is associated with reported availability of firearms across Chicago neighbourhoods. Data were collected as part of the Project on Human Development in Chicago Neighborhoods (PHDCN), a combined neighbourhood and individual level study of the city of Chicago. The study used data from 837 PHDCN participants between the ages of 17 and 22, residing in 170 different neighbourhoods. Gun availability was measured via participant reports on whether they had carried a gun and whether they perceived gun access to be easy in their community. Data on suicides and homicides were obtained from the Chicago Department of Health. A 10% change in the proportion of homicides committed by a gun in a neighbourhood was associated with a 20% increase in both the odds of reported gun access and reported gun carrying (p=0.002 and 0.048, respectively). The proportion of firearm related suicides was not associated with either of those self reported measures. The proportion of firearm related homicides, but not the proportion of firearm related suicides, is a useful predictor of gun availability across small areas such as neighbourhoods.

Beyond the Protein Matrix : Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction

NARCIS (Netherlands)

Martinoli, Christian; Dudek, Hanna M.; Orru, Roberto; Edmondson, Dale E.; Fraaije, Marco W.; Mattevi, Andrea

2013-01-01

A general question in biochemistry is the interplay between the chemical properties of cofactors and the surrounding protein matrix. Here, the functions of NADP(+) and FAD are explored by investigation of a representative monooxygenase reconstituted with chemically modified cofactor analogues. Like

Quantum localization and protein-assisted vibrational energy flow in cofactors

International Nuclear Information System (INIS)

Leitner, David M

2010-01-01

Quantum effects influence vibrational dynamics and energy flow in biomolecules, which play a central role in biomolecule function, including control of reaction kinetics. Lifetimes of many vibrational modes of proteins and their temperature dependence, as determined by quantum golden-rule-based calculations, exhibit trends consistent with experimental observation and distinct from estimates based on classical modeling. Particularly notable are quantum coherence effects that give rise to localization of vibrational states of sizable organic molecules in the gas phase. Even when such a molecule, for instance a cofactor, is embedded in a protein, remnants of quantum localization survive that influence vibrational energy flow and its dependence on temperature. We discuss these effects on the mode-damping rates of a cofactor embedded in a protein, using the green fluorescent protein chromophore as a specific example. We find that for cofactors of this size embedded in their protein and solvent environment at room temperature a golden-rule calculation often overestimates the mode-damping rate.

Low Emittance Guns for the ILC Polarized Electron Beam

International Nuclear Information System (INIS)

Clendenin, J. E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R. E.; Maruyama, T.; Miller, R. H.; Wang, J. W.; Zhou, F.

2007-01-01

Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of ≥200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while ≥500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

Low Emittance Guns for the ILC Polarized Electron Beam

International Nuclear Information System (INIS)

Clendenin, J.E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R.E.; Maruyama, T.; Miller, R.H.; Wang, J.W.; Zhou, F.; SLAC

2006-01-01

Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of (ge)200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while (ge)500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

Growth and scintillation properties of BaMgF4

International Nuclear Information System (INIS)

Yanagida, Takayuki; Kawaguchi, Noriaki; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Kamada, Kei; Yokota, Yuui; Yoshikawa, Akira; Chani, Valery

2010-01-01

By using the micro-pulling down (μ-PD) method, the barium magnesium fluoride (BaMgF 4 ) single crystalline scintillator was produced. The crystal was cut and mirror polished to the physical dimensions of 1x2x10 mm 3 for examination of scintillation properties. BaMgF 4 demonstrated ∼70% transmittance in wavelength range above 170 nm, and strong emission peaking around 205 nm was observed under X-ray excitation. The absolute light yield of BaMgF 4 was 1300±100 ph/MeV, and the decay time profile showed two components as 0.57±0.01 (70%) and 2.2±0.31 (30%) ns at room temperature.

Advances in DC photocathode electron guns

International Nuclear Information System (INIS)

Dunham M, Bruce; Heartmann, P.; Reza Kazimi; Hongxiu Liu; Poelker, B.M.; Price, J.S.; Rutt, P.M.; Schneider, W.J.; Sinclair K, Charles

1998-01-01

At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughout. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion back-bombardment, and precise control of all of the electrons emitted from the cathode. In this paper, the authors will review recent results and discuss implications for future photocathode guns

Advances in DC photocathode electron guns

International Nuclear Information System (INIS)

Dunham, B. M.; Hartmann, P.; Kazimi, R.; Liu, H.; Poelker, B. M.; Price, J. S.; Rutt, P. M.; Schneider, W. J.; Sinclair, C. K.

1999-01-01

At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughput. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion backbombardment, and precise control of all of the electrons emitted from the cathode. In this paper, we will review recent results and discuss implications for future photocathode guns

A compact electron gun using field emitter array

International Nuclear Information System (INIS)

Asakawa, M.R.; Ikeda, A.; Miyabe, N.; Yamaguchi, S.; Kusaba, M.; Tsunawaki, Y.

2008-01-01

A compact electron gun using field emitter array has been developed. With a simple triode configuration consisting of FEA, mid-electrode and anode electrode, the electron gun produces a parallel beam with a diameter of 0.5 mm. This electron gun is applicable for compact radiation sources such as Cherenkov free-electron lasers

Development of the electron gun control system of SSRF

International Nuclear Information System (INIS)

Zhou Dayong; Lin Guoqiang; Liu Dekang; Shen Liren

2010-01-01

An electron gun is the key part of a linac, the beam quality of which depends on beam quality of the electron gun, hence the need of a stable control system of the electron gun to ensure its safe operation.In this paper, we report our progresses in developing the linac's electron gun control system of Shanghai Synchrotron Radiation Facility (SSRF). It uses PLC as the device controllers, with the monitoring software developed on EPICS. The whole system is connected by Ethernet. The PLC and Ethernet technology ensures good reliability and easy maintenance of the electron gun control system. (authors)

Single-crystalline MgAl2O4 spinel nanotubes using a reactive and removable MgO nanowire template

International Nuclear Information System (INIS)

Fan Hongjin; Knez, Mato; Scholz, Roland; Nielsch, Kornelius; Pippel, Eckhard; Hesse, Dietrich; Goesele, Ulrich; Zacharias, Margit

2006-01-01

Using MgO nanowires as a reactive template, we fabricated for the first time single-crystal MgAl 2 O 4 spinel nanotubes through an interfacial solid-state reaction of MgO-Al 2 O 3 core-shell nanowires. Single-crystal MgO nanowires are coated with a conformal thin layer of amorphous Al 2 O 3 via atomic layer deposition. Subsequent annealing at 700 deg. C activates the interfacial reaction between MgO and Al 2 O 3 , transforming the alumina shell into a spinel shell. Finally, after etching away the remaining MgO core in ammonia sulfuric solution, MgAl 2 O 4 spinel nanotubes are obtained. As a transition from conventional planar spinel layers via thin-film interface reactions, our result might open a window for the fabrication of a wide variety of MgO-based spinel one-dimensional nanostructures

Characterisation of 100 kW electron beam melting gun and its adaptation as electron gun for high power DC electron accelerators

International Nuclear Information System (INIS)

Banerjee, Srutarshi; Bhattacharjee, Dhruva; Waghmare, Abhay; Tiwari, Rajnish; Bakhtsingh, R.I.; Dasgupta, K.; Gupta, Sachin; Prakash, Baibhaw; Jha, M.N.

2015-01-01

The paper deals with the characterization of the 100 kW electron beam melting gun for its adaptation in high power DC Electron Accelerators. The indigenously designed electron beam melting system at BARC is chosen for characterization. It comprises of electron gun as source of electrons, two electromagnetic focusing lenses viz. upper focusing lens and lower focusing lens for beam focusing, intermediate beam aperture for vacuum decoupling between gun region and melt zone, deflection and oscillation lens for maneuvering the beam on the melt charge and water cooled crucible that acts as a beam dump. In this system, the electron gun is designed for 40 kV and 100 kW corresponding to a maximum beam current of 2.5 A. The electron gun uses directly heated spiral tungsten filament. The operating temperature of the filament is 2800 °K. The focusing electrode and the anode profile are designed based on Pierce geometry. High Power DC Electron Accelerators require high currents of 1 A. The beam must comply with the requirement of 40 mm beam diameter and 10 mrad divergence at the exit of the electron gun. The characterization of the existing electron gun was done to find out all the beam parameters, for e.g. beam size, beam divergence, perveance etc. to be adapted or to be modified for the design of electron gun for high power DC accelerators. This paper shows limitations and the possible solutions for design of high power DC accelerators. (author)

Spheromak experiment using separate guns for formation and sustainment

International Nuclear Information System (INIS)

Brown, M.R.; Martin, A.

1996-01-01

An experiment is described that incorporates the use of separate magnetized plasma guns for formation and sustainment of a spheromak. It is shown that energy coupling efficiency approaches unity if the gun and spheromak are of comparable size. A large gun should be able to operate at lower current and therefore lower voltage. In addition, it is expected that a gun matched to the size of the spheromak will cause less perturbation to the equilibrium. It is proposed to use a smaller gun for spheromak formation and a large, efficient gun for sustainment. The theoretical basis for the experiment is developed, and the details of the experiment are described. A prediction of the equilibrium magnetic flux surfaces using the EFIT code is presented. 28 refs., 3 figs., 1 tab

Recent advances in high-brightness electron guns at AES

International Nuclear Information System (INIS)

Bluem, H.; Todd, A.M.M.; Cole, M.D.; Rathke, J.; Schultheiss, T.

2003-01-01

We describe a number of active Advanced Energy Systems projects pertaining to the development of advanced, high-brightness electron guns for various applications. These projects include a fully superconducting, CW RF gun, nearing test, that utilizes the niobium surface as the photocathode material. An integrated 100 mA, low emittance DC/SRF gun, ideal as an injector for ERL-type light sources and intended as the injector for a 100 kW FEL, is in late design stage. A parallel high-power, CW, normal-conducting L-band RF gun project has just begun. The early performance analysis for this gun also shows good promise as an injector for ERL-type light sources. Lastly, a fully axisymmetric RF gun, operating in X-band, is being studied as a source of extremely bright electron bunches

Particle transport and gas feed during gun injection

International Nuclear Information System (INIS)

Fowler, T K.

1999-01-01

It is shown that ion and neutral transport during gun injection tends to equalize the density in the spheromak to that in the open-line current channel. Since a gun operating at or near the ion saturation current requires a minimum density, because of transport these gun requirements also determine a minimum density in the spheromak that increases as the field increases. Hence attaining high fields by gun injection sets lower limits on the density, which in turn limits the temperature of the plasma and increases its ohmic resistance. Estimates of these effects are given using 0-D models calibrated to CTX, as guidance to 2-D UEDGE calculations in progress. For gun power levels in SSPX and the Pulsed Spheromak reactor, we find that buildup persists to the highest field levels of interest

Stereotactic breast biopsy with a biopsy gun

International Nuclear Information System (INIS)

Parker, S.H.; Lovin, J.; Luethke, J.; Jobe, W.E.; Hopper, K.D.; Yakes, W.F.

1989-01-01

With the recent introduction of stereotactic mammographic localizing devices, the authors have been performing histologic core needle breast biopsies in which the Bard biopsy gun is used in conjunction with sterotactic guidance. The authors have performed 60 breast gun biopsies with 16-gauge and 18-gauge biopsy-cut needles. These biopsies were followed immediately by traditional surgical excision. Pathologic results correlated well in 52 of the 60 patients, including 10 of 13 cancers. Three of the eight negative correlations occurred when diagnosis was made on gun biopsy but not on surgical biopsy. The stereotactic- guided gun biopsies appear to approach the surgical gold standard, decrease patient discomfort and potential disfigurement, lower the cost of breast biopsy, and lower the threshold necessary to perform breast biopsy

Lasers for RF guns: Proceedings

International Nuclear Information System (INIS)

Srinivasan-Rao, T.

1994-01-01

In the past decade, laser driven RF guns have matured from a device under development to a proven source for high brightness and low emittance electron beams. The reliability of the electron beam from these sources is dictated by the laser system that drives it. In addition, capabilities of the laser systems play a vital role in the design of the electron source for future machines such as the TESLA and NLC. The purpose of this workshop was to provide a forum for discussing the design criteria for the laser systems so that the reliability of the existing sources could be improved and the future machines could be serviced. The Workshop brought together experts in RF Guns, accelerators, and lasers, from both the commercial and academic community. Most of the presentations, discussions and conclusions at the workshop are included in these proceedings. The contents are divided into three sections, Section I contains the invited talks that outline the requirements of the RF Guns and the capabilities of the laser systems to meet these requirements. Section II includes most of the papers presented in the poster session. These papers describe various laser systems used with electron guns, schemes to modify the laser beam profile to optimize the electron bunch, and computer simulations of electron trajectories. Section III contains the summaries of the working groups. As the summary section indicates, with sufficient feed back systems, the electron gun could be made to operate reliably with minimum downtime, using commercial lasers currently available. The design of laser systems for future colliders depend critically on the choice of the cathode m the gun and its efficiency. Tentative designs of laser systems for the TESLA test facility and LCLS had been drawn assuming a copper cathode. Using a more efficient cathode will ease the energy requirement of the laser and simplify the design. The individual papers have been cataloged separately elsewhere

Development of the Antares electron gun

International Nuclear Information System (INIS)

Stine, R.; Leland, W.; Mansfield, C.; Rosocha, L.; Jansen, J.; Gibson, R.; Allen, G.

1984-01-01

Antares is the Los Alamos National Laboratory 40-kJ, 1-ns, CO 2 laser system that is now operational. This laser system was developed for the Intertial Confinement Fusion (ICF) program and is beginning target experiments. The distributed circuit modeling, design and operation of the large electron gun developed for the final laser power amplifier are reviewed. This gun is significant because of the large electron current area, 9 m 2 ; the number of emitter blades, 48; the dual cathode current return; and the coaxial geometry and grid control. The gun components and their development are discussed. These include the emitter blades, the coaxial grid (to maintain constant electron current during the 5-μs pulse), the bonded stacked-ring insulator (to electrically insulate the grid/cathode), the Kapton/aluminum electron transmission windows (to provide an interface between gun vacuum and laser gas) and the vacuum shell (operated at a vacuum of 10 -6 torr). A unique pressure diagnostic is also discussed

College Students Opinions on Gun Violence.

Science.gov (United States)

Lewis, Rhonda K; LoCurto, Jamie; Brown, Kyrah; Stowell, David; Maryman, J'Vonnah; Dean, Amber; McNair, Thoi; Ojeda, Debbie; Siwierka, Julia

2016-06-01

Gun violence and control issues have become serious public health problems. This study gathered the opinions from 419 college students from a Midwestern University. Participants were asked about beliefs about purchasing assault weapons, beliefs about bringing handguns to college campuses and beliefs about contributing factors that lead to gun violence. Participants completed surveys online. The findings showed that overall 54 % of respondents believed that military assault weapons should be banned and 53 % agree that teachers should be allowed to carry a registered handgun on campus. There were statistically significant differences between males and females on these issues. For instance, females believed military assault weapons and high capacity magazines should be banned more than 1.9 times (p = .004) p gun violence were decline in parenting and family values (17 %), gang involvement (14 %), bullying (13.8 %) and guns being easy to obtain (13.8 %). Limitations and implications for policy work are discussed.

Application of NAD(P)H oxidase for cofactor regeneration in dehydrogenase catalyzed oxidations

DEFF Research Database (Denmark)

Rehn, Gustav; Pedersen, Asbjørn Toftgaard; Woodley, John

2016-01-01

alcohol dehydrogenases. However, their effective use requires an effective regeneration of the oxidized nicotinamide cofactor (NAD(P)+), which is critical for the economic feasibility of the process. NAD(P)H oxidase is an enzyme class of particular interest for this cofactor regeneration since it enables...

rf traveling-wave electron gun for photoinjectors

Science.gov (United States)

Schaer, Mattia; Citterio, Alessandro; Craievich, Paolo; Reiche, Sven; Stingelin, Lukas; Zennaro, Riccardo

2016-07-01

The design of a photoinjector, in particular that of the electron source, is of central importance for free electron laser (FEL) machines where a high beam brightness is required. In comparison to standard designs, an rf traveling-wave photocathode gun can provide a more rigid beam with a higher brightness and a shorter pulse. This is illustrated by applying a specific optimization procedure to the SwissFEL photoinjector, for which a brightness improvement up to a factor 3 could be achieved together with a double gun output energy compared to the reference setup foreseeing a state-of-the-art S-band rf standing-wave gun. The higher brightness is mainly given by a (at least) double peak current at the exit of the gun which brings benefits for both the beam dynamics in the linac and the efficiency of the FEL process. The gun design foresees an innovative coaxial rf coupling at both ends of the structure which allows a solenoid with integrated bucking coil to be placed around the cathode in order to provide the necessary focusing right after emission.

Rational modification of Corynebacterium glutamicum dihydrodipicolinate reductase to switch the nucleotide-cofactor specificity for increasing l-lysine production.

Science.gov (United States)

Xu, Jian-Zhong; Yang, Han-Kun; Liu, Li-Ming; Wang, Ying-Yu; Zhang, Wei-Guo

2018-03-25

l-lysine is an important amino acid in animals and humans and NADPH is a vital cofactor for maximizing the efficiency of l-lysine fermentation. Dihydrodipicolinate reductase (DHDPR), an NAD(P)H-dependent enzyme, shows a variance in nucleotide-cofactor affinity in bacteria. In this study, we rationally engineered Corynebacterium glutamicum DHDPR (CgDHDPR) to switch its nucleotide-cofactor specificity resulting in an increase in final titer (from 82.6 to 117.3 g L -1 ), carbon yield (from 0.35 to 0.44 g [g glucose] -1 ) and productivity (from 2.07 to 2.93 g L -1  hr -1 ) of l-lysine in JL-6 ΔdapB::Ec-dapB C115G,G116C in fed-batch fermentation. To do this, we comparatively analyzed the characteristics of CgDHDPR and Escherichia coli DHDPR (EcDHDPR), indicating that hetero-expression of NADH-dependent EcDHDPR increased l-lysine production. Subsequently, we rationally modified the conserved structure of cofactor-binding motif, and results indicated that introducing the mutation K11A or R13A in CgDHDPR and introducing the mutation R16A or R39A in EcDHDPR modifies the nucleotide-cofactor affinity of DHDPR. Lastly, the effects of these mutated DHDPRs on l-lysine production were investigated. The highest increase (26.2%) in l-lysine production was observed for JL-6 ΔdapB::Ec-dapB C115G,G116C , followed by JL-6 Cg-dapB C37G,G38C (21.4%) and JL-6 ΔdapB::Ec-dapB C46G,G47C (15.2%). This is the first report of a rational modification of DHDPR that enhances the l-lysine production and yield through the modulation of nucleotide-cofactor specificity. © 2018 Wiley Periodicals, Inc.

The Use of an Electron Microchannel as a Self-Extracting and Focusing Plasma Cathode Electron Gun

International Nuclear Information System (INIS)

Cornish, S.; Khachan, J.

2016-01-01

A new and simple type of electron gun is presented. Unlike conventional electron guns, which require a heated filament or extractor, accelerator and focusing electrodes, this gun uses the collimated electron microchannels of an inertial electrostatic confinement (IEC) discharge to achieve the same outcome. A cylindrical cathode is placed coaxially within a cylindrical anode to create the discharge. Collimated beams of electrons and fast neutrals emerge along the axis of the cylindrical cathode. This geometry isolates one of the microchannels that emerge in a negatively biased IEC grid. The internal operating pressure range of the gun is 35-190 mTorr. A small aperture separates the gun from the main vacuum chamber in order to achieve a pressure differential. The chamber was operated at pressures of 4-12 mTorr. The measured current produced by the gun was 0.1-3 mA (0.2-14 mA corrected measurement) for discharge currents of 1-45 mA and discharge voltages of 0.5-12 kV. The collimated electron beam emerges from the aperture into the vacuum chamber. The performance of the gun is unaffected by the pressure differential between the vacuum chamber and the gun. This allows the aperture to be removed and the chamber pressure to be equal to the gun pressure if required. (paper)

The Use of an Electron Microchannel as a Self-Extracting and Focusing Plasma Cathode Electron Gun

Science.gov (United States)

Cornish, S.; Khachan, J.

2016-02-01

A new and simple type of electron gun is presented. Unlike conventional electron guns, which require a heated filament or extractor, accelerator and focusing electrodes, this gun uses the collimated electron microchannels of an inertial electrostatic confinement (IEC) discharge to achieve the same outcome. A cylindrical cathode is placed coaxially within a cylindrical anode to create the discharge. Collimated beams of electrons and fast neutrals emerge along the axis of the cylindrical cathode. This geometry isolates one of the microchannels that emerge in a negatively biased IEC grid. The internal operating pressure range of the gun is 35-190 mTorr. A small aperture separates the gun from the main vacuum chamber in order to achieve a pressure differential. The chamber was operated at pressures of 4-12 mTorr. The measured current produced by the gun was 0.1-3 mA (0.2-14 mA corrected measurement) for discharge currents of 1-45 mA and discharge voltages of 0.5-12 kV. The collimated electron beam emerges from the aperture into the vacuum chamber. The performance of the gun is unaffected by the pressure differential between the vacuum chamber and the gun. This allows the aperture to be removed and the chamber pressure to be equal to the gun pressure if required.

Strong gun laws are not enough: the need for improved enforcement of secondhand gun transfer laws in Massachusetts.

Science.gov (United States)

Braga, Anthony A; Hureau, David M

2015-10-01

Research suggests that an overwhelming majority of crime guns were transferred by private sellers before recovery by law enforcement. Unfortunately, most states do not regulate these transactions. This study examines whether analyses of state-level private transfer data could be used to develop interventions to reduce the supply of handguns to violent criminals. Traced Boston crime handguns first sold at Massachusetts license dealers were matched to state secondhand gun transfer data. Logistic regression and descriptive statistics were used to analyze the characteristics of recovered crime guns and in-state primary and secondary market transaction patterns. For crime handguns with records of secondary market transactions in Massachusetts, many rapidly move from private transfer to recovery by the police. Unfortunately, important transaction data on the in-state sources of nearly 63% of recovered handguns were not readily available to law enforcement agencies. Data on private transfers of guns could be used to prevent violent injuries by reducing criminal access. However, the passage of strong private transfer gun laws needs to be accompanied by investments in the vigorous enforcement of reporting requirements. Copyright © 2015 Elsevier Inc. All rights reserved.

Long pulse, plasma cathode E-gun

International Nuclear Information System (INIS)

Goebel, D.M.; Schumacher, R.W.; Watkins, R.M.

1993-01-01

A unique, long-pulse E-gun has been developed for high-power tube applications. The Hollow-Cathode-Plasma (HCP) E-gun overcomes the limitations of conventional thermionic-cathode guns that have limited current density (typically ≤ 10 A/cm 2 ) or field-emission guns that offer high current density but suffer from short pulsewidth capability (typically 50 A/cm 2 ), long-pulse operation without gap closure, and also requires no cathode-heater power. The gun employs a low-pressure glow discharge inside a hollow cathode (HC) structure to provide a stable, uniform plasma surface from which a high current-density electron beam can be extracted. The plasma density is controlled by a low-voltage HC discharge pulser to produce the desired electron current density at the first grid of a multi-grid accelerator system. A dc high-voltage electron-beam supply accelerates the electrons across the gap, while the HC pulser modulates the beam current to generate arbitrary pulse waveforms. The electron accelerator utilizes a multi-aperture array that produces a large area, high perveance (>35 μpervs) beam consisting initially of many individual beamlets. The E-beam is normally operated without an applied magnetic field in the ion-focused regime, where the plasma produced by beam ionization of a background gas space-charge neutralizes the beam, and the Bennett self-pinch compresses the beamlets and increases the current density. The self-pinched beam has been observed to propagate over a meter without beam breakup or instabilities. The HCP E-gun has been operated at voltages up to 150 kV, currents up to 750 A, and pulse lengths of up to 120 μsec

The Development of the Linac Coherent Light Source RF Gun

International Nuclear Information System (INIS)

Dowell, D

2008-01-01

The Linac Coherent Light Source (LCLS) is the first x-ray laser user facility based upon a free electron laser (FEL) requiring extraordinary beam quality to saturate at 1.5 angstroms within a 100 meter undulator.[1] This new type of light source is using the last kilometer of the three kilometer linac at SLAC to accelerate the beam to an energy as high as 13.6 GeV and required a new electron gun and injector to produce a very bright beam for acceleration. At the outset of the project it was recognized that existing RF guns had the potential to produce the desired beam but none had demonstrated it. Therefore a new RF gun or at least the modification of an existing gun was necessary. The parameters listed in Table 1 illustrate the unique characteristics of LCLS which drive the requirements for the electron gun as given in Table 2. The gun beam quality needs to accommodate emittance growth as the beam is travels through approximately one kilometer of linac and two bunch compressors before reaching the undulator. These beam requirements were demonstrated during the recent commissioning runs of the LCLS injector and linac [2] due to the successful design, fabrication, testing and operation of the LCLS gun. The goal of this paper is to relate the technical background of how the gun was able to achieve and in some cases exceed these requirements by understanding and correcting the deficiencies of the prototype s-band RF photocathode gun, the BNL/SLAC/UCLA Gun III. This paper begins with a brief history and technical description of Gun III and the Gun Test Facility (GTF) at SLAC, and studies of the gun's RF and emittance compensation solenoid. The work at the GTF identified the gun and solenoid deficiencies, and helped to define the specifications for the LCLS gun. Section 1.1.5 describes the modeling used to compute and correct the gun RF fields and Section 1.1.6 describes the use of these fields in the electron beam simulations. The magnetic design and measurements of

Structural Phase Transitions of Mg(BH4)2 under Pressure

International Nuclear Information System (INIS)

George, L.; Drozd, V.; Saxena, S.; Bardaji, E.; Fichtner, M.

2009-01-01

The structural stability of Mg(BH4)2, a promising hydrogen storage material, under pressure has been investigated in a diamond anvil cell up to 22 GPa with combined synchrotron X-ray diffraction and Raman spectroscopy. The analyses show a structural phase transition around 2.5 GPa and again around 14.4 GPa. An ambient-pressure phase of Mg(BH4)2 has a hexagonal structure (space group P61, a = 10.047(3) A, c = 36.34(1) A, and V = 3176(1) A3 at 0.2 GPa), which agrees well with early reports. The structure of high-pressure phase is found to be different from reported theoretical predictions; it also does not match the high-temperature phase. The high-pressure polymorph of Mg(BH4)2 is found to be stable on decompression, similar to the case of the high-temperature phase. Raman spectroscopic study shows a similarity in high-pressure behavior of as-prepared Mg(BH4)2 and its high-temperature phase.

Gun Carrying by High School Students in Boston, MA: Does Overestimation of Peer Gun Carrying Matter?

Science.gov (United States)

Hemenway, David; Vriniotis, Mary; Johnson, Renee M.; Miller, Matthew; Azrael, Deborah

2011-01-01

This paper investigates: (1) whether high school students overestimate gun carrying by their peers, and (2) whether those students who overestimate peer gun carrying are more likely to carry firearms. Data come from a randomly sampled survey conducted in 2008 of over 1700 high school students in Boston, MA. Over 5% of students reported carrying a…

Advances in DC photocathode electron guns

International Nuclear Information System (INIS)

Dunham, B.M.; Hartmann, P.; Kazimi, R.; Liu, H.; Poelker, B.M.; Price, J.S.; Rutt, P.M.; Schneider, W.J.; Sinclair, C.K.

1999-01-01

At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughput. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion backbombardment, and precise control of all of the electrons emitted from the cathode. In this paper, we will review recent results and discuss implications for future photocathode guns. copyright 1999 American Institute of Physics

The polarized electron gun for the SLC

International Nuclear Information System (INIS)

Schultz, D.C.; Clendenin, J.; Frisch, J.; Hoyt, E.; Klaisner, L.; Woods, M.; Wright, D.; Zolotorev, M.

1992-03-01

A new polarized electron gun for use on the SLC at SLAC has been built and tested. It is a diode gun with a laser driven GaAs photocathode. It is designed to provide short (2ns) pulses of 10 A at 160 kV at 120 Hz. The design features of the gun and results from a testing program on a new and dedicated beam line are presented. Early results from operation on the SLC will also be shown

Characterization of cable gun plasma with a charge collector array

International Nuclear Information System (INIS)

Chen Yulan; Zeng Zhengzhong; Sun Fengju; Kuai Bin; Qiu Aici; Yin Jiahui; Cong Peitian; Liang Tianxue

2003-01-01

The density, drift velocity and reproducibility of the plasma produced by a cable plasma gun array have been measured with a charge collector array. The plasma is used to prefill a coaxial plasma-opening switch with a conducting time approaching 0.4 μs. The reproducibility of the plasma source in subsequent shots is better than 5%. Near the gun nozzle and the opposite electrode, the plasma density amounts to 10 15 cm -3 , which is 2 times to 3 times that in the gap between the two coaxial electrodes. A plasma drift velocity of about 2.4 cm/μs is observed from the time of flight of the charged particles. Both plasma density and drift velocity increase almost linearly with the rise in charge voltage

Tri-Service Green Gun Barrel (PP 1074)

National Research Council Canada - National Science Library

Rusch, Lawrence F

2003-01-01

...) PP 1074 Tri-Service Green Gun Barrel. The program's goal was to develop an environmentally friendly process for depositing wear and erosion resistant materials onto gun bores replacing the current hazardous aqueous electro-deposition...

Progress on a cryogenically cooled RF gun polarized electron source

Energy Technology Data Exchange (ETDEWEB)

Fliller, R.P., III; Edwards, H.; /Fermilab

2006-08-01

RF guns have proven useful in multiple accelerator applications. An RF gun capable of producing polarized electrons is an attractive electron source for the ILC or an electron-ion collider. Producing such a gun has proven elusive. The NEA GaAs photocathode needed for polarized electron production is damaged by the vacuum environment in an RF gun. Electron and ion back bombardment can also damage the cathode. These problems must be mitigated before producing an RF gun polarized electron source. In this paper we report continuing efforts to improve the vacuum environment in a normal conducting RF gun by cooling it with liquid nitrogen after a high temperature vacuum bake out. We also report on a design of a cathode preparation chamber to produce bulk GaAs photocathodes for testing in such a gun. Future directions are also discussed.

Stability and performance studies of the PITZ photoelectron gun

Energy Technology Data Exchange (ETDEWEB)

Isaev, Igor

2018-02-15

The invention of free electron lasers (FELs) opened new opportunities for the investigation of natural phenomena. However, the operation of a FEL requires high energy, high peak current electron beams with very small transverse emittance which causes extreme requirements for the corresponding electron sources. Besides the high beam quality, the electron sources must have very high operational stability and reliability. One of the electron source types which satisfy FEL requirements is a photoelectron gun. Photoelectron guns combine photoemissive electron generation and direct acceleration in a Radio Frequency (RF) cavity. The Photo Injector Test facility at DESY, Zeuthen site (PITZ), was established as a test stand of the electron source for FELs like FLASH and the European XFEL in Hamburg. The studies of the beam emittance at PITZ showed that the gun is able to produce electron beams with emittance even smaller than it is required by XFEL specifications. But the experiments on the emittance revealed discrepancies between expected gun behavior and observation, such as the difference in optimal parameters for the smallest emittance value, asymmetry of the transverse beam profile and the phase spaces. The work performed at PITZ includes preparation of several RF guns for their subsequent operation at FLASH and the European XFEL. RF conditioning of a gun cavity is one of the major steps of the preparation of a high brightness electron source required for modern FELs. A thorough procedure is applied to increase the peak and average RF power in the gun cavity, including an increase of the repetition rate and RF pulse length combined with a gun solenoid current sweep. The main goals of this thesis are: (1) an attempt of deep understanding of physical processes taking place during operation of a photoelectron gun (conditioning process, parameters adjustments); (2) definition of operational problems sources and explanation of the experimentally obtained results in the gun

Stability and performance studies of the PITZ photoelectron gun

International Nuclear Information System (INIS)

Isaev, Igor

2018-02-01

The invention of free electron lasers (FELs) opened new opportunities for the investigation of natural phenomena. However, the operation of a FEL requires high energy, high peak current electron beams with very small transverse emittance which causes extreme requirements for the corresponding electron sources. Besides the high beam quality, the electron sources must have very high operational stability and reliability. One of the electron source types which satisfy FEL requirements is a photoelectron gun. Photoelectron guns combine photoemissive electron generation and direct acceleration in a Radio Frequency (RF) cavity. The Photo Injector Test facility at DESY, Zeuthen site (PITZ), was established as a test stand of the electron source for FELs like FLASH and the European XFEL in Hamburg. The studies of the beam emittance at PITZ showed that the gun is able to produce electron beams with emittance even smaller than it is required by XFEL specifications. But the experiments on the emittance revealed discrepancies between expected gun behavior and observation, such as the difference in optimal parameters for the smallest emittance value, asymmetry of the transverse beam profile and the phase spaces. The work performed at PITZ includes preparation of several RF guns for their subsequent operation at FLASH and the European XFEL. RF conditioning of a gun cavity is one of the major steps of the preparation of a high brightness electron source required for modern FELs. A thorough procedure is applied to increase the peak and average RF power in the gun cavity, including an increase of the repetition rate and RF pulse length combined with a gun solenoid current sweep. The main goals of this thesis are: (1) an attempt of deep understanding of physical processes taking place during operation of a photoelectron gun (conditioning process, parameters adjustments); (2) definition of operational problems sources and explanation of the experimentally obtained results in the gun

The design of gridded pierce guns for accelerators

International Nuclear Information System (INIS)

True, R.

1985-01-01

It is vital to employ ultra-laminar beams in electron linacs to maximize charge transport to the target. This paper presents numerical and experimental design techniques which have led to significant improvements in gridded Pierce guns used in microwave tubes and electron linacs. The paper concludes with two gun/injector concepts which have demonstrated enhanced performance over standard triode Pierce guns

Development of plasma cathode electron guns

Science.gov (United States)

Oks, Efim M.; Schanin, Peter M.

1999-05-01

The status of experimental research and ongoing development of plasma cathode electron guns in recent years is reviewed, including some novel upgrades and applications to various technological fields. The attractiveness of this kind of e-gun is due to its capability of creating high current, broad or focused beams, both in pulsed and steady-state modes of operation. An important characteristic of the plasma cathode electron gun is the absence of a thermionic cathode, a feature which leads to long lifetime and reliable operation even in the presence of aggressive background gas media and at fore-vacuum gas pressure ranges such as achieved by mechanical pumps. Depending on the required beam parameters, different kinds of plasma discharge systems can be used in plasma cathode electron guns, such as vacuum arcs, constricted gaseous arcs, hollow cathode glows, and two kinds of discharges in crossed E×B fields: Penning and magnetron. At the present time, plasma cathode electron guns provide beams with transverse dimension from fractional millimeter up to about one meter, beam current from microamperes to kiloamperes, beam current density up to about 100 A/cm2, pulse duration from nanoseconds to dc, and electron energy from several keV to hundreds of keV. Applications include electron beam melting and welding, surface treatment, plasma chemistry, radiation technologies, laser pumping, microwave generation, and more.

OPTIMIZATION OF OPERATION PARAMETERS OF 80-KEV ELECTRON GUN

Directory of Open Access Journals (Sweden)

JEONG DONG KIM

2014-06-01

As a first step, the electron generator of an 80-keV electron gun was manufactured. In order to produce the high beam power from electron linear accelerator, a proper beam current is required form the electron generator. In this study, the beam current was measured by evaluating the performance of the electron generator. The beam current was determined by five parameters: high voltage at the electron gun, cathode voltage, pulse width, pulse amplitude, and bias voltage at the grid. From the experimental results under optimal conditions, the high voltage was determined to be 80 kV, the pulse width was 500 ns, and the cathode voltage was from 4.2 V to 4.6 V. The beam current was measured as 1.9 A at maximum. These results satisfy the beam current required for the operation of an electron linear accelerator.

Plasma-gun fueling for tokamak reactors

International Nuclear Information System (INIS)

Ehst, D.A.

1980-11-01

In light of the uncertain extrapolation of gas puffing for reactor fueling and certain limitations to pellet injection, the snowplow plasma gun has been studied as a fueling device. Based on current understanding of gun and plasma behavior a design is proposed, and its performance is predicted in a tokamak reactor environment

Plasma focusing in coaxial gun

International Nuclear Information System (INIS)

Soliman, H.M.; Masoud, M.M.; El-Khalafawy, T.

1986-01-01

A capacitor bank has been discharged between two coaxial electrodes of 6.6 cm outer diameter, 3.2 cm inner diameter and length of 31.5 cm. filled with hydrogen gas at pressure of 310 μHg. Results show that, the axial and radial plasma current reach a maximum value at a position adjacent to the gun muzzle, at which the plasma focus occurs. The measurement of the electron temperature and density and azimuthal electric field along the axis of the expansion chamber, gives a maximum value at z∼18 cm from the gun muzzle, while the axial plasma current and velocity has a minimum value at that position. These results indicate that a second point of a plasma focus has been formed at z∼18 cm from the gun muzzle, along the axis of the expansion chamber

Progress of electron gun systems for the e-/e+ linac at KEK

International Nuclear Information System (INIS)

Ohsawa, S.; Ogawa, Y.; Otake, Y.; Yokota, M.; Fukuda, S.; Saito, Y.; Enomoto, A.; Azuma, O.; Iwata, H.; Asami, A.

1989-01-01

Several improvements have been made in the electron gun systems of the 2.5 GeV PF linac and the Positron Generator. In the electron gun system of the PF linac, the vacuum system and the focusing system have been modified, and the anode current was increased. In the case of a short pulse beam with a width of 2 ns, the anode current has been more than 200 mA for about a year with a constant pulse voltage output of a grid pulser. Injection time of the electron beam into the Accumulation Ring of TRISTAN has been normally less than 10 s. Meanwhile in the electron gun system of the Positron Generator, improvements have been made mainly in the following two points; (1) a raise of injection voltage of the gun from 115 kV to 150 kV, which was made possible by using a newly designed insulator, and (2) an increase of pulse voltage output of a grid pulser by use of new transistors with a high slew rate. As a result of these improvements, a maximum anode peak current of 12 A with a pulse width of 4 ns can be obtained, which satisfies the design parameters of the gun system. 7 refs., 8 figs

Therminoic gun control system for the CEBAF injector

International Nuclear Information System (INIS)

Pico, R.; Diamond, B.; Fugitt, J.; Bork, R.

1989-01-01

The injector for the CEBAF accelerator must produce a high-quality electron beam to meet the overall accelerator specifications. A Hermosa electron gun with a 2 mm-diameter cathode and a control aperture has been chosen as the electron source. This must be controlled over a wide range of operating conditions to meet the beam specifications and to provide flexibility for accelerator commissioning. The gun is controlled using Computer Automated Measurement and Control (CAMAC IEEE-583) technology. The system employs the CAMAC-based control architecture developed at CEBAF. The control system has been tested, and early operating data on the electron gun and the injector beam transport system has been obtained. This system also allows gun parameters to be stored at the operator location, without paralyzing operation. This paper describes the use of this computer system in the control of the CEBAF electron gun. 2 refs., 6 figs., 1 tab

Genome-scale consequences of cofactor balancing in engineered pentose utilization pathways in Saccharomyces cerevisiae.

Directory of Open Access Journals (Sweden)

Amit Ghosh

Full Text Available Biofuels derived from lignocellulosic biomass offer promising alternative renewable energy sources for transportation fuels. Significant effort has been made to engineer Saccharomyces cerevisiae to efficiently ferment pentose sugars such as D-xylose and L-arabinose into biofuels such as ethanol through heterologous expression of the fungal D-xylose and L-arabinose pathways. However, one of the major bottlenecks in these fungal pathways is that the cofactors are not balanced, which contributes to inefficient utilization of pentose sugars. We utilized a genome-scale model of S. cerevisiae to predict the maximal achievable growth rate for cofactor balanced and imbalanced D-xylose and L-arabinose utilization pathways. Dynamic flux balance analysis (DFBA was used to simulate batch fermentation of glucose, D-xylose, and L-arabinose. The dynamic models and experimental results are in good agreement for the wild type and for the engineered D-xylose utilization pathway. Cofactor balancing the engineered D-xylose and L-arabinose utilization pathways simulated an increase in ethanol batch production of 24.7% while simultaneously reducing the predicted substrate utilization time by 70%. Furthermore, the effects of cofactor balancing the engineered pentose utilization pathways were evaluated throughout the genome-scale metabolic network. This work not only provides new insights to the global network effects of cofactor balancing but also provides useful guidelines for engineering a recombinant yeast strain with cofactor balanced engineered pathways that efficiently co-utilizes pentose and hexose sugars for biofuels production. Experimental switching of cofactor usage in enzymes has been demonstrated, but is a time-consuming effort. Therefore, systems biology models that can predict the likely outcome of such strain engineering efforts are highly useful for motivating which efforts are likely to be worth the significant time investment.

Gun violence in Americans' social network during their lifetime.

Science.gov (United States)

Kalesan, Bindu; Weinberg, Janice; Galea, Sandro

2016-12-01

The overall burden of gun violence death and injury in the US is now well understood. However, no study has shown the extent to which gun violence is associated with the individual lives of Americans. We used fatal and non-fatal gun injury rates in 2013 from Centers for Disease Control and Prevention's Web-based Injury Statistics Query and Reporting System (WISQARS) and generally accepted estimates about the size of an American's social network to determine the likelihood that any given person will know someone in their personal social network who is a victim of gun violence during their lifetime. We derived estimates in the overall population and among racial/ethnic groups and by gun-injury intent. The likelihood of knowing a gun violence victim within any given personal network over a lifetime is 99.85% (99.8% to 99.9%). The likelihood among non-Hispanic white, black, Hispanic and other race Americans were 97.1%, 99.9%, 99.5% and 88.9% respectively. Nearly all Americans of all racial/ethnic groups are likely to know a victim of gun violence in their social network during their lifetime. Copyright © 2016 Elsevier Inc. All rights reserved.

Organic cofactors participated more frequently than transition metals in redox reactions of primitive proteins.

Science.gov (United States)

Ji, Hong-Fang; Chen, Lei; Zhang, Hong-Yu

2008-08-01

Protein redox reactions are one of the most basic and important biochemical actions. As amino acids are weak redox mediators, most protein redox functions are undertaken by protein cofactors, which include organic ligands and transition metal ions. Since both kinds of redox cofactors were available in the pre-protein RNA world, it is challenging to explore which one was more involved in redox processes of primitive proteins? In this paper, using an examination of the redox cofactor usage of putative ancient proteins, we infer that organic ligands participated more frequently than transition metals in redox reactions of primitive proteins, at least as protein cofactors. This is further supported by the relative abundance of amino acids in the primordial world. Supplementary material for this article can be found on the BioEssays website. (c) 2008 Wiley Periodicals, Inc.

Momentum equation for arc-driven rail guns

International Nuclear Information System (INIS)

Batteh, J.H.

1984-01-01

In several models of arc-driven rail guns, the rails are assumed to be infinitely high to simplify the calculation of the electromagnetic fields which appear in the momentum equation for the arc. This assumption leads to overestimates of the arc pressures and accelerations by approximately a factor of 2 for typical rail-gun geometries. In this paper, we develop a simple method for modifying the momentum equation to account for the effect of finite-height rails on the performance of the rail gun and the properties of the arc. The modification is based on an integration of the Lorentz force across the arc cross section at each axial location in the arc. Application of this technique suggests that, for typical rail-gun geometries and moderately long arcs, the momentum equation appropriate for infinite-height rails can be retained provided that the magnetic pressure term in the equation is scaled by a factor which depends on the effective inductance of the gun. The analysis also indicates that the magnetic pressure gradient actually changes sign near the arc/projectile boundary because of the magnetic fields associated with the arc current

rf traveling-wave electron gun for photoinjectors

Directory of Open Access Journals (Sweden)

Mattia Schaer

2016-07-01

Full Text Available The design of a photoinjector, in particular that of the electron source, is of central importance for free electron laser (FEL machines where a high beam brightness is required. In comparison to standard designs, an rf traveling-wave photocathode gun can provide a more rigid beam with a higher brightness and a shorter pulse. This is illustrated by applying a specific optimization procedure to the SwissFEL photoinjector, for which a brightness improvement up to a factor 3 could be achieved together with a double gun output energy compared to the reference setup foreseeing a state-of-the-art S-band rf standing-wave gun. The higher brightness is mainly given by a (at least double peak current at the exit of the gun which brings benefits for both the beam dynamics in the linac and the efficiency of the FEL process. The gun design foresees an innovative coaxial rf coupling at both ends of the structure which allows a solenoid with integrated bucking coil to be placed around the cathode in order to provide the necessary focusing right after emission.

Evaluation of Smart Gun Technologies preliminary report

Energy Technology Data Exchange (ETDEWEB)

Weiss, D.R.

1996-01-01

The Smart Gun Technology Project has a goal to eliminate the capability of an unauthorized user from firing a law enforcement officer`s firearm by implementing {open_quote}smart{close_quote} technologies. Smart technologies are those that can in some manner identify an officer. This report will identify, describe, and grade various technologies as compared to the requirements that were obtained from officers. This report does not make a final recommendation for a smart gun technology, nor does it give the complete design of a smart gun system.

Gun utopias? Firearm access and ownership in Israel and Switzerland.

Science.gov (United States)

Rosenbaum, Janet E

2012-02-01

The 2011 attempted assassination of a US representative renewed the national gun control debate. Gun advocates claim mass-casualty events are mitigated and deterred with three policies: (a) permissive gun laws, (b) widespread gun ownership, (c) and encouragement of armed civilians who can intercept shooters. They cite Switzerland and Israel as exemplars. We evaluate these claims with analysis of International Crime Victimization Survey (ICVS) data and translation of laws and original source material. Swiss and Israeli laws limit firearm ownership and require permit renewal one to four times annually. ICVS analysis finds the United States has more firearms per capita and per household than either country. Switzerland and Israel curtail off-duty soldiers' firearm access to prevent firearm deaths. Suicide among soldiers decreased by 40 per cent after the Israeli army's 2006 reforms. Compared with the United States, Switzerland and Israel have lower gun ownership and stricter gun laws, and their policies discourage personal gun ownership.

Gun Dynamics Laboratory

Data.gov (United States)

Federal Laboratory Consortium — The Gun Dynamics Laboratory is a research multi-task facility, which includes two firing bays, a high bay area and a second floor laboratory space. The high bay area...

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

International Nuclear Information System (INIS)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-01-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

Science.gov (United States)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-07-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

A high voltage test stand for electron gun qualification for LINACs

International Nuclear Information System (INIS)

Wanmode, Yashwant D.; Mulchandani, J.; Acharya, M.; Bhisikar, A.; Singh, H.G.; Shrivastava, Purushottam

2011-01-01

An electron gun lest stand has been developed at RRCAT. The test stand consists of a high voltage pulsed power supply, electron gun filament supply, grid supply, UHV system and electron gun current measurement system. Several electron guns developed indigenously were evaluated on this test stand. The shielding is provided for the electron gun set up. Electron gun tests can be tested upto 55 kV with pulse width of 15 microsecs and pulse repetition rates up to 200 Hz. The technical details of the subsystems are furnished and results of performance of the test stand have been reported in this paper. (author)

Gun barrel erosion - Comparison of conventional and LOVA gun propellants

NARCIS (Netherlands)

Hordijk, A.C.; Leurs, O.

2006-01-01

The research department Energetic Materials within TNO Defence, Security and Safety is involved in the development and (safety and insensitive munitions) testing of conventional (nitro cellulose based) and thermoplastic elastomer (TPE) based gun propellants. Recently our testing capabilities have

Beam dynamics simulations in the photo-cathode RF gun for the CLIC test facility

International Nuclear Information System (INIS)

Marchand, P.; Rinolfi, L.

1992-01-01

The CERN CLIC Test Facility (CTF) uses an RF gun with a laser driven photo-cathode in order to generate electron pulses of high charge (≥10 nC) and short duration (≤20 ps). The RF gun consists of a 3 GHz 1 + 1/2 cell cavity based on the design originally proposed at BNL which minimizes the non-linearities in the transverse field. The beam dynamics in the cavity is simulated by means of the multiparticle tracking code PARMELA. The results are compared to previous simulations as well as to the first experimental data. (author). 4 refs., 4 tabs., 4 figs

Engineering design of the PLX- α coaxial gun

Science.gov (United States)

Cruz, E.; Brockington, S.; Case, A.; Luna, M.; Witherspoon, F. D.; Thio, Y. C. Francis; PLX-α Team

2017-10-01

We describe the engineering and technical improvements, as well as provide a detailed overview of the design choices, of the latest PLX- α coaxial gun designed for the 60-gun scaling study of spherically imploding plasma liners as a standoff driver for plasma-jet-driven magneto-inertial fusion. Each coaxial gun incorporates a fast, dense gas injection and triggering system, a compact low-weight pfn with integral sparkgap switching, and a contoured gap designed to suppress the blow-by instability. The evolution of the latest Alpha gun is presented with emphasis on its upgraded performance. Changes include a faster more robust gas valve, better-quality ceramic insulator material and enhancements to overall design layout. These changes result in a gun with increased repeatability, reduced potential failure modes, improved fault tolerance and better than expected efficiency. A custom 600- μF, 5-kV pfn and a set of six inline sparkgap switches operated in parallel are mounted directly to the back of the gun, and are designed to reduce inductance, cost, and complexity, maximize efficiency and system reliability, and ensure symmetric current flow. This work supported by the ARPA-E ALPHA Program under contract DE-AR0000566 and Strong Atomics, LLC.

Spectrometer gun

Science.gov (United States)

Waechter, David A.; Wolf, Michael A.; Umbarger, C. John

1985-01-01

A hand-holdable, battery-operated, microprocessor-based spectrometer gun includes a low-power matrix display and sufficient memory to permit both real-time observation and extended analysis of detected radiation pulses. Universality of the incorporated signal processing circuitry permits operation with various detectors having differing pulse detection and sensitivity parameters.

Separation of xylose and glucose using an integrated membrane system for enzymatic cofactor regeneration and downstream purification

DEFF Research Database (Denmark)

Morthensen, Sofie Thage; Sigurdardóttir, Sigyn Björk; Meyer, Anne S.

2017-01-01

Mixtures of xylose, glucose and pyruvate were fed to a membrane bioreactor equipped with a charged NF membrane (NTR 7450). Value-added products were obtained in the reactor via enzymatic cofactor-dependent catalysis of glucose to gluconic acid and pyruvate to lactic acid, respectively. The initial...... cofactor (NADH) concentration could be decreased to 10% of the stoichiometric value (relative to glucose) without compromising process time and substrate conversion via i) efficient cofactor regeneration and ii) high retention of cofactor (R=0.98) in the membrane bioreactor. Furthermore, accumulation...

Mass Shootings, Mental Illness, and Gun Control.

Science.gov (United States)

Philpott-Jones, Sean

2018-03-01

In the wake of the Stoneman Douglas School shooting, Republican and Democratic leaders-like the American electorate they represent-remain sharply divided in their responses to gun violence. They are united in their condemnation of these mass shootings, but they disagree about whether stricter or looser gun control laws are the answer. Those on the right side of the political aisle suggest that the issue is one of mental illness rather than gun control. Conversely, those who are more liberal or progressive in their political learnings are quick to condemn attempts to reframe the issue of mass shootings as a mental health problem. Both sides are wrong. Mass shootings are indeed partially a mental health problem, albeit one poorly addressed by our current laws and policies. But the solution to mass shootings also needs to consider strategies that may reduce gun violence in general. © 2018 The Hastings Center.

Acceleration of solid pellets using a plasma gun

International Nuclear Information System (INIS)

Buller, T.L.; Turnbull, R.J.; Kim, K.

1979-01-01

The use of solid pellets of hydrogen isotopes to refuel thermonuclear fusion reactors based on the tokamak configuration will require that the pellets be accelerated to high velocities. One possible method of acceleration is to interact a fast plasma from a plasma gun with the pellets. In this paper preliminary results are given on the acceleration of solid pellets with a plasma gun. The plasma-gun requirements for successful acceleration to high velocities are discussed

Cofactors in allergic reactions to food : physical exercise and alcohol are the most important

NARCIS (Netherlands)

Versluis, Astrid; van Os-Medendorp, Harmieke; Kruizinga, Astrid G; Blom, W Marty; Houben, Geert F; Knulst, André C

2016-01-01

INTRODUCTION: Involvement of cofactors, like physical exercise, alcohol consumption and use of several types of medication, are associated with more severe food allergic symptoms. However, there is limited evidence on how often cofactors play a role in food allergic reactions. The study aimed to get

Handgun waiting periods reduce gun deaths.

Science.gov (United States)

Luca, Michael; Malhotra, Deepak; Poliquin, Christopher

2017-11-14

Handgun waiting periods are laws that impose a delay between the initiation of a purchase and final acquisition of a firearm. We show that waiting periods, which create a "cooling off" period among buyers, significantly reduce the incidence of gun violence. We estimate the impact of waiting periods on gun deaths, exploiting all changes to state-level policies in the Unites States since 1970. We find that waiting periods reduce gun homicides by roughly 17%. We provide further support for the causal impact of waiting periods on homicides by exploiting a natural experiment resulting from a federal law in 1994 that imposed a temporary waiting period on a subset of states. Copyright © 2017 the Author(s). Published by PNAS.

Role of 3d-ions for radiation defect production in MgO and MgAl2O4

International Nuclear Information System (INIS)

Mironova, N.A.; Grinvald, G.A.; Skvortsova, V.N.

1985-01-01

Optical properties of MgO and MgAl 2 O 4 crystals containing chromium and manganese impurity ions were studied by exposure to but all types of radiation. Complicated defects of the ''impurity-intrinsic matrix defect'' type were preferably considered. It has been shown that different symmetry center forming chromium ions in MgO:Crsup(3+) change their valency with various efficiency being exposed to external action. Besides, the compensating vacancy does not participate in the hole center formation. For MgOxAl 2 O 3 single crystals the presence of octahedrally coordinated manganese ions suppresses the hole center creation by gamma-irradiation. Studying luminescence spectra of Crsup(3+) ions in MgAl 2 O 4 it has been states that neutron irradiation increases the degree of inversion for the magnesium-aluminium spinel

Contoured-gap coaxial guns for imploding plasma liner experiments

Science.gov (United States)

Witherspoon, F. D.; Case, A.; Brockington, S.; Cassibry, J. T.; Hsu, S. C.

2014-10-01

Arrays of supersonic, high momentum flux plasma jets can be used as standoff compression drivers for generating spherically imploding plasma liners for driving magneto-inertial fusion, hence the name plasma-jet-driven MIF (PJMIF). HyperV developed linear plasma jets for the Plasma Liner Experiment (PLX) at LANL where two guns were successfully tested. Further development at HyperV resulted in achieving the PLX goal of 8000 μg at 50 km/s. Prior work on contoured-gap coaxial guns demonstrated an approach to control the blowby instability and achieved substantial performance improvements. For future plasma liner experiments we propose to use contoured-gap coaxial guns with small Minirailgun injectors. We will describe such a gun for a 60-gun plasma liner experiment. Discussion topics will include impurity control, plasma jet symmetry and topology (esp. related to uniformity and compactness), velocity capability, and techniques planned for achieving gun efficiency of >50% using tailored impedance matched pulse forming networks. Mach2 and UAH SPH code simulations will be included. Work supported by US DOE DE-FG02-05ER54810.

Self-bunching electron guns

CERN Document Server

Mako, F; Weilhammer, Peter

1999-01-01

We report on three electron gun projects that are aimed at power tube and injector applications. The purpose of the work is to develop robust electron guns which produce self-bunched, high-current-density beams. We have demonstrated cold emission, long life, and tolerance to contamination. The cold emission process is based on secondary electron emission. FMT has studied this resonant bunching process which gives rise to high current densities (0.01-5 kA/cm/sup 2/), high charge bunches (up to 100 nC/bunch), and short pulses (1-100 ps) for frequencies from 1 to 12 GHz. The beam pulse width is nominally ~5% of the RF period. The first project is the L-Band Micro-Pulse Gun (MPG). Measurements show ~40 ps long microbunches at ~20 A/cm/sup 2/ without contamination due to air exposure. Lifetime testing has been carried out for about 18 months operating at 1.25 GHz for almost 24 hours per day at a repetition rate of 300 Hz and 5 mu s-long macro- pulses. About 5.8*10/sup 13/ micro-bunches or 62,000 coulombs have pass...

Beam emittance measurement from CERN thermionic guns

International Nuclear Information System (INIS)

Kester, O.; Rao, R.; Rinolfi, L.

1992-01-01

In the LEP Injector Linacs (LIL) a thermionic gun provides electron beams with different peak intensities at an energy of 80 keV. The beam emittances were estimated from the EGUN programme. Since the gun is of triode type, the main contribution to the emittance comes from the grid. The simulation programme does not model the real geometry by assuming a cylindrical symmetry, while the grid does not have such symmetry. A Gun Test Facility (GTF), allowing emittance measurements, based on the 3-gradients-method was installed. The experimental results are presented. (author) 6 refs.; 6 figs

Field reversal produced by a plasma gun

International Nuclear Information System (INIS)

Hartman, C.W.; Condit, W.; Granneman, E.H.A.; Prono, D.; Smith, A.C. Jr.; Taska, J.; Turner, W.C.

1980-01-01

Experimental results are presented of the production of Field-Reversed Plasma with a high energy coaxial plasma gun. The gun is magnetized with solenoids inside the center electrode and outside the outer electrode so that plasma emerging from the gun entrains the radial fringer field at the muzzle. The plasma flow extends field lines propagating a high electrical conductivity, the flux inside the center electrode should be preserved. However, for low flux, the trapped flux exceeds by 2 or more the initial flux, possibly because of helical deformation of the current channel extending from the center electrode

Alpha Fuels Environmental Test Facility impact gun

International Nuclear Information System (INIS)

Anderson, C.G.

1978-01-01

The Alpha Fuels Environmental Test Facility (AFETF) impact gun is a unique tool for impact testing 238 PuO 2 -fueled heat sources of up to 178-mm dia at velocities to 300 m/s. An environmentally-sealed vacuum chamber at the muzzle of the gun allows preheating of the projectile to 1,000 0 C. Immediately prior to impact, the heat source projectile is completely sealed in a vacuum-tight catching container to prevent escape of its radioactive contents should rupture occur. The impact velocity delivered by this gas-powered gun can be regulated to within +-2%

CD/MCD/VTVH-MCD Studies of Escherichia coli Bacterioferritin Support a Binuclear Iron Cofactor Site.

Science.gov (United States)

Kwak, Yeonju; Schwartz, Jennifer K; Huang, Victor W; Boice, Emily; Kurtz, Donald M; Solomon, Edward I

2015-12-01

Ferritins and bacterioferritins (Bfrs) utilize a binuclear non-heme iron binding site to catalyze oxidation of Fe(II), leading to formation of an iron mineral core within a protein shell. Unlike ferritins, in which the diiron site binds Fe(II) as a substrate, which then autoxidizes and migrates to the mineral core, the diiron site in Bfr has a 2-His/4-carboxylate ligand set that is commonly found in diiron cofactor enzymes. Bfrs could, therefore, utilize the diiron site as a cofactor rather than for substrate iron binding. In this study, we applied circular dichroism (CD), magnetic CD (MCD), and variable-temperature, variable-field MCD (VTVH-MCD) spectroscopies to define the geometric and electronic structures of the biferrous active site in Escherichia coli Bfr. For these studies, we used an engineered M52L variant, which is known to eliminate binding of a heme cofactor but to have very minor effects on either iron oxidation or mineral core formation. We also examined an H46A/D50A/M52L Bfr variant, which additionally disrupts a previously observed mononuclear non-heme iron binding site inside the protein shell. The spectral analyses define a binuclear and an additional mononuclear ferrous site. The biferrous site shows two different five-coordinate centers. After O2 oxidation and re-reduction, only the mononuclear ferrous signal is eliminated. The retention of the biferrous but not the mononuclear ferrous site upon O2 cycling supports a mechanism in which the binuclear site acts as a cofactor for the O2 reaction, while the mononuclear site binds the substrate Fe(II) that, after its oxidation to Fe(III), migrates to the mineral core.

Production of field-reversed plasma with a magnetized coaxial plasma gun

International Nuclear Information System (INIS)

Turner, W.C.; Granneman, E.H.A.; Hartman, C.W.; Prono, D.S.; Taska, J.; Smith, A.C. Jr.

1981-01-01

Experimental data are presented on the production of field-reversed deuterium plasma by a modified coaxial plasma gun. The coaxial gun is constructed with solenoid coils along the inner and outer electrodes that, together with an external guide field solenoid, form a magnetic cusp at the gun muzzle. The net flux inside the inner electrode is arranged to be opposite the external guide field and is the source of field-reversed flux trapped by the plasma. The electrode length is 145 cm, the diameter of the inner (outer) electrode is 15 cm (32 cm). The gun discharge is driven with a 232-μF 40-kV capacitor bank. Acceleration of plasma through the magnetic cusp at the gun muzzle results in entrainment of field-reversed flux that is detected by magnetic probes 75 cm from the gun muzzle. Field-reversed plasma has been produced for a variety of experimental conditions. In one typical case, the guide magnetic field was B 0 =4.8 kG and the change in axial magnetic field ΔB/sub z/ normalized to B 0 was ΔB/sub z/ /B 0 =-3.1. Total field-reversed flux (poloidal flux) obtained by integrating ΔB/sub z/ profiles is in the range 2 x 10 3 kG cm 2 . Measurement of the orthogonal field component indicates a sizable toroidal field peaked off axis at rapprox. =10 cm with a magnitude of roughly one-half the poloidal field component that is measured on magnetic axis. Reconnection of the poloidal field lines has not been established for the data reported in the paper and will be addressed in future experiments which attempt to trap and confine the field-reversed plasma in a magnetic mirror

Insight into cofactor recognition in arylamine N-acetyltransferase enzymes

DEFF Research Database (Denmark)

Xu, Ximing; Li de la Sierra-Gallay, Inés; Kubiak, Xavier Jean Philippe

2015-01-01

Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes that catalyze the acetyl-CoA-dependent acetylation of arylamines. To better understand the mode of binding of the cofactor by this family of enzymes, the structure of Mesorhizobium loti NAT1 [(RHILO)NAT1] was determined...... for Bacillus anthracis NAT1 and Homo sapiens NAT2. Therefore, in contrast to previous data, this study shows that different orthologous NATs can bind their cofactors in a similar way, suggesting that the mode of binding CoA in this family of enzymes is less diverse than previously thought. Moreover......, it supports the notion that the presence of the `mammalian/eukaryotic insertion loop' in certain NAT enzymes impacts the mode of binding CoA by imposing structural constraints....

Design study on an independently-tunable-cells thermionic RF gun

International Nuclear Information System (INIS)

Hama, H.; Tanaka, T.; Hinode, F.; Kawai, M.

2006-01-01

Characteristics of a thermionic RF gun have been studied by a 3-D simulation code developed using an FDTD (Finite Difference Time Domain) method as a Maxwell's equations solver. The gun is consists of two independent power feeding cavities, so that we call it independently-tunable-cells (ITC)'-RF gun. The first cell is the cathode cell and the second one is an accelerating cell. The ITC gun can be operated at various modes of different RF-power ratio and phase between two cavities. Simulation study shows a velocity-bunching like effect may be occurred in the gun, so that the short pulse beam from the thermionic RF gun is a better candidate to produce the coherent THz synchrotron radiation. Expected bunch length with a total charge of ∼20 pC (1% energy width from the top energy) is around 200 fs (fwhm). Even the beam energy extracted from the gun is varied by which the input powers are changed, almost same shape of the longitudinal phase space can be produced by tuning the phase. (author)

Youth, Guns, and the Juvenile Justice System. Research Report.

Science.gov (United States)

Butts, Jeffrey; Coggeshall, Mark; Gouvis, Caterina; Mears, Daniel; Travis, Jeremy; Waul, Michelle; White, Ruth

This report documents trends in youth gun violence and the response within the justice system, noting the growing variety of data resources available to investigate the effect of new gun laws on youth, communities, and public safety. The first section reviews recent trends, examining the major wave of gun violence in the United States during the…

Guns, Suicide, COPD and Sleep

Directory of Open Access Journals (Sweden)

Robbins RA

2018-03-01

Full Text Available No abstract available. Article truncated at 150 words. Within the past year two tragic events, the shootings in Las Vegas and Florida have renewed the debate about guns. The politics and the money that fuels the political debate have sharply divided politicians. As tragic as these mass shootings are, deaths by suicide far outnumber the loss of live in these shootings. In 2014 suicide was the tenth most common cause of death with 42,826 lives lost (1. Half of the suicides were by firearm (21,386. The medical profession has traditionally been reluctant to speak about politically sensitive issues such as abortion, sexuality, and guns. However, beginning early in this millennium some medical societies such as the American Academy of Pediatrics, the US Preventative Services Task Force and even the Department of Veterans Affairs were suggesting physicians ask patients about gun behavior, but a few patients complained (2-5. There were some anecdotal reports of patients feeling “pressured” to answer …

Electron gun for the positron generator

International Nuclear Information System (INIS)

Fukuda, S.; Ogawa, Y.; Saito, Y.

1986-01-01

A triode electron gun has been installed on the Positron Generator at KEK, and brought into test operation. It involves a grid-cathode assembly currently used in a planner triode. The cathode has a diameter of 10 mm and is coated with Ba-Sr-Ca oxide. Because of the short grid-cathode distance (0.18 mm), the relatively low grid pulse voltages makes it possible to draw a high current. The assembly has a small vacuum flange which allows its easy replacement. Emission current from the oxide cathode is sensitive to residual gases, therefore, the vacuum system is carefully made and the pressure is kept in the range of 10 -9 Torr even when the accelerator is on. The grid pulser is a line type pulser using multi-stage avalanche transistors as a switch. The pulse width of 10 nsec has been used for the test to investigate the gun characteristics. The performance of the gun has been tested with this pulser and the emission current of 9.7 A was achieved at an injection voltage of 110 kV. The characteristics of the gun are described together with the beam trace

Gun utopias? Firearm access and ownership in Israel and Switzerland

OpenAIRE

Rosenbaum, Janet

2011-01-01

The 2011 attempted assassination of a US representative renewed the national gun control debate. Gun advocates claim that mass-casualty events are mitigated and deterred with three policies: (1) permissive gun laws, (2) widespread gun ownership, (3) encouragement of armed civilians who can intercept shooters, and cite Switzerland and Israel as exemplars. We evaluate these claims with analysis of International Crime Victimization Survey (ICVS) data and translation of laws and original source m...

Corrosion behavior of die-cast Mg-4Al-2Sn-xCa alloy

Energy Technology Data Exchange (ETDEWEB)

Park, Kyung Chul; Kim, Byeong Ho; Kim, Kyung Ro [Defence Agency for Technology and Quality, Jinju (Korea, Republic of); Cho, Dae Hyun; Park, Ik Min [Pusan National University, Busan (Korea, Republic of)

2016-05-15

In the present work, the effect of Ca additions on microstructure and corrosion characteristics of high pressure die-cast Mg-4Al-2Sn alloy has been investigated. Mg-4Al-2Sn-xCa (x= 0, 0.3 and 0.7wt.%) alloy was prepared by using a high pressure die-casting method. Results indicated that the microstructure of Mg-4Al-2Sn alloy consisted of α-Mg, Mg{sub 17}Al{sub 12} and Mg{sub 2}Sn phase. With increase of Ca additions, CaMgSn phase was newly formed and grain size was sharply decreased. From the test results, the corrosion resistance of die-cast Mg-4Al-2Sn alloy was significantly improved by Ca addition. It is considered that stabilization of Mg(OH){sub 2} layer and refinements of microstructure with increase of Ca additions.

Growth and scintillation properties of BaMgF{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kawaguchi, Noriaki [Tokuyama Corporation, Shibuya 3-chome, Shibuya-ku, Tokyo 150-8383 (Japan); Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Kamada, Kei; Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Chani, Valery [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan)

2010-09-21

By using the micro-pulling down ({mu}-PD) method, the barium magnesium fluoride (BaMgF{sub 4}) single crystalline scintillator was produced. The crystal was cut and mirror polished to the physical dimensions of 1x2x10 mm{sup 3} for examination of scintillation properties. BaMgF{sub 4} demonstrated {approx}70% transmittance in wavelength range above 170 nm, and strong emission peaking around 205 nm was observed under X-ray excitation. The absolute light yield of BaMgF{sub 4} was 1300{+-}100 ph/MeV, and the decay time profile showed two components as 0.57{+-}0.01 (70%) and 2.2{+-}0.31 (30%) ns at room temperature.

Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase

Science.gov (United States)

Werther, Tobias; Wahlefeld, Stefan; Salewski, Johannes; Kuhlmann, Uwe; Zebger, Ingo; Hildebrandt, Peter; Dobbek, Holger

2017-07-01

How an enzyme activates its substrate for turnover is fundamental for catalysis but incompletely understood on a structural level. With redox enzymes one typically analyses structures of enzyme-substrate complexes in the unreactive oxidation state of the cofactor, assuming that the interaction between enzyme and substrate is independent of the cofactors oxidation state. Here, we investigate the Michaelis complex of the flavoenzyme xenobiotic reductase A with the reactive reduced cofactor bound to its substrates by X-ray crystallography and resonance Raman spectroscopy and compare it to the non-reactive oxidized Michaelis complex mimics. We find that substrates bind in different orientations to the oxidized and reduced flavin, in both cases flattening its structure. But only authentic Michaelis complexes display an unexpected rich vibrational band pattern uncovering a strong donor-acceptor complex between reduced flavin and substrate. This interaction likely activates the catalytic ground state of the reduced flavin, accelerating the reaction within a compressed cofactor-substrate complex.

Alterations of Mg2+ After Hemorrhagic Shock.

Science.gov (United States)

Lee, Mun-Young; Yang, Dong Kwon; Kim, Shang-Jin

2017-11-01

Hemorrhagic shock is generally characterized by hemodynamic instability with cellular hypoxia and diminishing cellular function, resulting from an imbalance between systemic oxygen delivery and consumption and redistribution of fluid and electrolytes. Magnesium (Mg) is the fourth most abundant cation overall and second most abundant intracellular cation in the body and an essential cofactor for the energy production and cellular metabolism. Data for blood total Mg (tMg; free-ionized, protein-bound, and anion-bound forms) and free Mg 2+ levels after a traumatic injury are inconsistent and only limited information is available on hemorrhagic effects on free Mg 2+ as the physiologically active form. The aim of this study was to determine changes in blood Mg 2+ and tMg after hemorrhage in rats identifying mechanism and origin of the changes in blood Mg 2+ . Hemorrhagic shock produced significant increases in blood Mg 2+ , plasma tMg, Na + , K + , Cl - , anion gap, partial pressures of oxygen, glucose, and blood urea nitrogen but significant decreases in RBC tMg, blood Ca 2+ , HCO 3 - , pH, partial pressures of carbon dioxide, hematocrit, hemoglobin, total cholesterol, and plasma/RBC ATP. During hemorrhagic shock, K + , anion gap, and BUN showed significant positive correlations with changes in blood Mg 2+ level, while Ca 2+ , pH, and T-CHO correlated to Mg 2+ in a negative manner. In conclusion, hemorrhagic shock induced an increase in both blood-free Mg 2+ and tMg, resulted from Mg 2+ efflux from metabolic damaged cell with acidosis and ATP depletion.

Gun Trafficking and the Southwest Border

Science.gov (United States)

2009-07-29

felons, drug traffickers, and juvenile gang members from acquiring firearms from gun traffickers. These criminals often acquire firearms from persons...renounced their U.S. citizenship; (8) persons restrained under a court-order from harassing, stalking , or threatening an intimate partner or child of... gang members from acquiring firearms from gun traffickers. These criminals often acquire firearms from a person who otherwise is not prohibited to

Improved DC Gun and Insulator Assembly

Energy Technology Data Exchange (ETDEWEB)

Neubauer, Michael [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2015-01-11

Many user facilities such as synchrotron radiation light sources and free electron lasers rely on DC high voltage photoguns with internal field gradients as high as 10 to 15 MV/m. These high gradients often lead to field emission which poses serious problems for the photocathode used to generate the electron beam and the ceramic insulators used to bias the photocathode at high voltage. Ceramic insulators are difficult to manufacture, require long commissioning times, and have poor reliability, in part because energetic electrons bury themselves in the ceramic causing a buildup of charge and eventual puncture, and also because large diameter ceramics are difficult to braze reliably. The lifetimes of photo cathodes inside high current DC guns exhibiting field emission are limited to less than a hundred hours. Reducing the surface gradients on the metals reduces the field emission, which serves to maintain the required ultrahigh vacuum condition. A novel gun design with gradients around 5 MV/m and operating at 350 kV, a major improvement over existing designs, was proposed that allows for the in-situ replacement of photo cathodes in axially symmetric designs using inverted ceramics. In this project, the existing JLAB CEBAF asymmetric gun design with an inverted ceramic support was modeled and the beam dynamics characterized. An improved structure was designed that reduces the surface gradients and improves the beam optics. To minimize the surface gradients, a number of electrostatic gun designs were studied to determine the optimum configuration of the critical electrodes within the gun structure. Coating experiments were carried out to create a charge dissipative coating for cylindrical ceramics. The phase II proposal, which was not granted, included the design and fabrication of an axially symmetric DC Gun with an inverted ceramic that would operate with less than 5 MV/m at 350 kV and would be designed with an in-situ replaceable photo-cathode.

Co-factors necessary for PPAR mediated transactivation of endogenous target genes

DEFF Research Database (Denmark)

Grøntved, Lars; Nielsen, Ronni; Stunnenberg, Henk

of endogenous target gene in different cell types are elusive. To mutually compare the ability of the PPAR subtypes to activate endogenous target genes in a given cell, PPARa, PPARb/d and PPARg2 were HA tagged and rapidly, equally and synchronously expressed using adenoviral delivery. Within a few hours after...... subtype specific activation of target genes. Accumulating evidence suggests that transcriptional co-factors can function as master regulators for nuclear receptors and impose promoter selectivity. To study co-factor necessity for PPAR mediated transactivation of endogenous target genes, specific co...

ELECTRON GUN

Science.gov (United States)

Christofilos, N.C.; Ehlers, K.W.

1960-04-01

A pulsed electron gun capable of delivering pulses at voltages of the order of 1 mv and currents of the order of 100 amperes is described. The principal novelty resides in a transformer construction which is disposed in the same vacuum housing as the electron source and accelerating electrode structure of the gun to supply the accelerating potential thereto. The transformer is provided by a plurality of magnetic cores disposed in circumferentially spaced relation and having a plurality of primary windings each inductively coupled to a different one of the cores, and a helical secondary winding which is disposed coaxially of the cores and passes therethrough in circumferential succession. Additional novelty resides in the disposition of the electron source cathode filament input leads interiorly of the transformer secondary winding which is hollow, as well as in the employment of a half-wave filament supply which is synchronously operated with the transformer supply such that the transformer is pulsed during the zero current portions of the half-wave cycle.

ION GUN

Science.gov (United States)

Dandl, R.A.

1961-10-24

An ion gun is described for the production of an electrically neutral ionized plasma. The ion gun comprises an anode and a cathode mounted in concentric relationship with a narrow annulus between. The facing surfaces of the rear portions of the anode and cathode are recessed to form an annular manifold. Positioned within this manifold is an annular intermediate electrode aligned with the an nulus between the anode and cathode. Gas is fed to the manifold and an arc discharge is established between the anode and cathode. The gas is then withdrawn from the manifold through the annulus between the anode and cathode by a pressure differential. The gas is then ionized by the arc discharge across the annulus. The ionized gas is withdrawn from the annulus by the combined effects of the pressure differential and a collimating magnetic field. In a 3000 gauss magnetic field, an arc voltage of 1800 volts, and an arc current of 0.2 amp, a plasma of about 3 x 10/sup 11/ particles/cc is obtained. (AEC)

Design and experimental results of a new electron gun using a magnetic multipole plasma generator

International Nuclear Information System (INIS)

Tanaka, S.; Yokoyama, K.; Akiba, M.; Araki, M.; Dairaku, M.; Inoue, T.; Mizuno, M.; Okumura, Y.; Ohara, Y.; Seki, M.; Watanabe, K.

1991-01-01

A new electron gun utilizing a magnetic multipole plasma generator was designed and fabricated as the heat source of the high heat flux test facility, called JEBIS (JAERI electron beam irradiation stand). By changing the acceleration grids, this electron gun is able to produce a pencil to a sheetlike electron beams up to 4 A at 100 keV for 1 ms to continuous mode. In this electron gun, magnetic lens system is not adopted to focus the electron beam, but the space charge neutralization effect by the beam plasma produced downstream of the electron gun is utilized to prevent the blow-up of the electron beam. In addition, high permeability metal is embedded in the first and the second grids to magnetically shield the earth field and the stray field from the beam bending magnet. It was experimentally demonstrated that wide range of heat flux from 0.2 MW/m 2 to over 2000 MW/m 2 can be realized at the test sample position about 1.7 m downstream of the electron gun

Where have all the gun deaths gone?

African Journals Online (AJOL)

Gun violence denialists recently dismissed the findings of two studies presented at a seminar co-hosted by Gun Free South Africa, the. Institute for Security Studies and the African. Policing Civilian Oversight Forum. Abrahams et al.[1] compared the profile of female homicides from two representative national samples.

Gun Control: The Debate and Public Policy.

Science.gov (United States)

Watkins, Christine

1997-01-01

Provides an overview and background information on the debate over gun control, as well as several teaching ideas. Handouts include a list of related topics drawn from various disciplines (economics, U.S. history), seven arguments for and against gun control, and a set of policy evaluation guidelines. (MJP)

Virtual cathode driven by short pulse electron gun

International Nuclear Information System (INIS)

Spassovsky, I.P.; Cho, Sung Oh; Lee, Jongmin; Lee, Byung-Cheol; Jeong, Young Uk; Messina, G.; Yovchev, I.G.; Nikolov, N.A.

1996-01-01

An electron gun has been developed by ENEA (Italy) to power a free-electron laser operating in the far infrared region. The device can also be used to drive various microwave sources. Numerical simulations were performed for the planned foil-diode vircator experiment to be carried out by ENEA. (author). 5 figs., 4 refs

Virtual cathode driven by short pulse electron gun

Energy Technology Data Exchange (ETDEWEB)

Spassovsky, I P; Cho, Sung Oh; Lee, Jongmin; Lee, Byung-Cheol; Jeong, Young Uk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of). Laboratory for Quantum Optics; Messina, G [ENEA, Roma-Frascati (Italy). INN-FIS-LAC; Yovchev, I G; Nikolov, N A [Sofia Univ. (Bulgaria). Faculty of Physics

1997-12-31

An electron gun has been developed by ENEA (Italy) to power a free-electron laser operating in the far infrared region. The device can also be used to drive various microwave sources. Numerical simulations were performed for the planned foil-diode vircator experiment to be carried out by ENEA. (author). 5 figs., 4 refs.

Automated gun biopsy of the prostate under ultrasound guide

International Nuclear Information System (INIS)

Yang, Ik; Lim, Jae Hoon; Ko, Young Tae; Lee, Dong Ho; Lim, Joo Won

1994-01-01

To assess the effectiveness and clinical usefulness of prostate biopsy by automated gun biopsy device under the transrectal ultrasonographic guidance, authors analysed the result of biopsy and the patients status after biopsy procedure. The subjects consisted of 24 patients with prostatic disease. Biopsy instrument was an automated gun biopsy device loaded with an 18 gauze biopsy needle. All the patients were admitted to the hospital. No analgesics was given. All the procedure was performed with the patient in left lateral decubitus. Biopsy was performed at 2-4 different points of the prostate in 22 cases, but recently, six different points were targeted in two patients. Biopsy specimens were sufficient in 21 cases but insufficient in three cases. Histologic examination of biopsy specimens showed that 13 cases were nodular hyperplasia, eight cases were cancerous and three cases were inflammation. There was no clinically significant complication. There was mild to moderate degree of pain in all patients. Tansrectal biopsy of the prostate with an automated gun biopsy device under ultrasonographic guidance is considered relatively easy, handy and useful procedure in patients with prostatic disease. The procedure may be performed on the out patient basis

Performance of the Brookhaven photocathode rf gun

International Nuclear Information System (INIS)

Batchelor, K.; Ben-Zvi, I.; Fernow, R.C.; Fischer, J.; Fisher, A.S.; Gallardo, J.; Ingold, G.; Kirk, H.G.; Leung, K.P.; Malone, R.; Pogorelsky, I.; Srinivasan-Rao, T.; Rogers, J.; Tsang, T.; Sheehan, J.; Ulc, S.; Woodle, M.; Xie, J.; Zhang, R.S.; Lin, L.Y.; McDonald, K.T.; Russell, D.P.; Hung, C.M.; Wang, X.J.

1991-01-01

The Brookhaven Accelerator Test Facility (ATF) uses a photocathode rf gun to provide a high-brightness electron beam intended for FEL and laser-acceleration experiments. The rf gun consists of 1 1/2 cells driven at 2856 MHz in π-mode with a maximum cathode field of 100 MV/m. To achieve long lifetimes, the photocathode development concentrates on robust metals such as copper, yttrium and samarium. We illuminate these cathodes with a 10-ps, frequency-quadrupled Nd:YAG laser. We describe the initial operation of the gun, including measurements of transverse and longitudinal emittance, quantum efficiencies, and peak current. The results are compared to models

Emittance compensation of CW DC-gun photoinjector

International Nuclear Information System (INIS)

Li Peng; Wu Dai; Xu Zhou; Li Ming; Yang Xingfan

2011-01-01

Emittance growth induced by space charge effect is very important, especially for CW DC-gun photoinjector. In this work, the linear space charge force and its effect on electron beam transverse emittance are studied, and the principle and properties of emittance compensation by solenoid are analyzed. The CAEP DC-gun photoinjector with a solenoid is also simulated by code Parmela. Simulated results indicate that the normalized transverse emittance of an 80 pC bunch at the 350 keV DC-gun ex-it is 5.14 mm · mrad. And after compensated by a solenoid, it becomes 1.27 mm · mrad. The emittance of beam is well compensated. (authors)

QUICKGUN: An algorithm for estimating the performance of two-stage light gas guns

International Nuclear Information System (INIS)

Milora, S.L.; Combs, S.K.; Gouge, M.J.; Kincaid, R.W.

1990-09-01

An approximate method is described for solving the equation of motion of a projectile accelerated by a two-stage light gas gun that uses high-pressure (<100-bar) gas from a storage reservoir to drive a piston to moderate speed (<400 m/s) for the purpose of compressing the low molecular weight propellant gas (hydrogen or helium) to high pressure (1000 to 10,000 bar) and temperature (1000 to 10,000 K). Zero-dimensional, adiabatic (isentropic) processes are used to describe the time dependence of the ideal gas thermodynamic properties of the storage reservoir and the first and second stages of the system. A one-dimensional model based on an approximate method of characteristics, or wave diagram analysis, for flow with friction (nonisentropic) is used to describe the nonsteady compressible flow processes in the launch tube. Linear approximations are used for the characteristic and fluid particle trajectories by averaging the values of the flow parameters at the breech and at the base of the projectile. An assumed functional form for the Mach number at the breech provides the necessary boundary condition. Results of the calculation are compared with data obtained from two-stage light gas gun experiments at Oak Ridge National Laboratory for solid deuterium and nylon projectiles with masses ranging from 10 to 35 mg and for projectile speeds between 1.6 and 4.5 km/s. The predicted and measured velocities generally agree to within 15%. 19 refs., 3 figs., 2 tabs

Low Energy Electron Gun on Board a Scientific Satellite GEOTAIL

OpenAIRE

TSUTSUI, Minoru; ONISHI, Yoshiaki; MATSUMOTO, Hiroshi; KIMURA, Iwane; 筒井, 稔; 大西, 嘉昭; 松本, 紘; 木村, 磐根

1988-01-01

A low energy electron gun to be used for beam-plasma interaction experiments by a scientific satellite GEOTAIL has been designed and manufactured. Electrodes of the gun have been modified from the Pierce type gun because of the use of a directly heated cathode. Spatial density distributions of beam electrons emitted from the new gun have been measured in a large vacuum chamber, and characteristic curves of emission currents for some beam energies and cathode powers have been checked repeatedl...

A comparison of amorphous calcium carbonate crystallization in aqueous solutions of MgCl2 and MgSO4: implications for paleo-ocean chemistry

Science.gov (United States)

Han, Mei; Zhao, Yanyang; Zhao, Hui; Han, Zuozhen; Yan, Huaxiao; Sun, Bin; Meng, Ruirui; Zhuang, Dingxiang; Li, Dan; Liu, Binwei

2018-04-01

Based on the terminology of "aragonite seas" and "calcite seas", whether different Mg sources could affect the mineralogy of carbonate sediments at the same Mg/Ca ratio was explored, which was expected to provide a qualitative assessment of the chemistry of the paleo-ocean. In this work, amorphous calcium carbonate (ACC) was prepared by direct precipitation in anhydrous ethanol and used as a precursor to study crystallization processes in MgSO4 and MgCl2 solutions having different concentrations at 60 °C (reaction times 240 and 2880 min). Based on the morphology of the aragonite crystals, as well as mineral saturation indices and kinetic analysis of geochemical processes, it was found that these crystals formed with a spherulitic texture in 4 steps. First, ACC crystallized into columnar Mg calcite by nearly oriented attachment. Second, the Mg calcite changed from columnar shapes into smooth dumbbell forms. Third, the Mg calcite transformed into rough dumbbell or cauliflower-shaped aragonite forms by local dissolution and precipitation. Finally, the aragonite transformed further into spherulitic radial and irregular aggregate forms. The increase in Ca2+ in the MgSO4 solutions compared with the MgCl2 solutions indicates the fast dissolution and slow precipitation of ACC in the former solutions. The phase transition was more complete in the 0.005 M MgCl2 solution, whereas Mg calcite crystallized from the 0.005 M MgSO4 solution, indicating that Mg calcite could be formed more easily in an MgSO4 solution. Based on these findings, aragonite and Mg calcite relative to ACC could be used to provide a qualitative assessment of the chemistry of the paleo-ocean. Therefore, calcite seas relative to high-Mg calcite could reflect a low concentration MgSO4 paleo-ocean, while aragonite seas could be related to an MgCl2 or high concentration of MgSO4 paleo-ocean.

Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.

Science.gov (United States)

Barupala, Dulmini P; Dzul, Stephen P; Riggs-Gelasco, Pamela Jo; Stemmler, Timothy L

2016-02-15

In humans, the bulk of iron in the body (over 75%) is directed towards heme- or Fe-S cluster cofactor synthesis, and the complex, highly regulated pathways in place to accomplish biosynthesis have evolved to safely assemble and load these cofactors into apoprotein partners. In eukaryotes, heme biosynthesis is both initiated and finalized within the mitochondria, while cellular Fe-S cluster assembly is controlled by correlated pathways both within the mitochondria and within the cytosol. Iron plays a vital role in a wide array of metabolic processes and defects in iron cofactor assembly leads to human diseases. This review describes progress towards our molecular-level understanding of cellular heme and Fe-S cluster biosynthesis, focusing on the regulation and mechanistic details that are essential for understanding human disorders related to the breakdown in these essential pathways. Copyright © 2016 Elsevier Inc. All rights reserved.

Development of beam diagnostic devices for characterizing electron guns

International Nuclear Information System (INIS)

Bhattacharjee, D.; Tiwari, R.; Jayaprakash, D.; Mishra, R.L.; Sarukte, H.; Waghmare, A.; Thakur, N.; Dixit, K.P.

2015-01-01

The electron guns for the DC accelerators and RF Linacs are designed and developed at EBC/APPD/BARC, Kharghar. These electron guns need to be characterized for its design and performance. Two test benches were developed for characterizing the electron guns. Various beam diagnostic devices for measuring beam currents and beam sizes were developed. Conical faraday cup, segmented faraday cup, slit scanning bellows movement arrangement, multi-plate beam size measurement setup, multi- wire beam size measurement setup, Aluminum foil puncture assembly etc. were developed and used. The paper presents the in-house development of various beam diagnostics for characterizing electron guns and their use. (author)

Prospects for deflagration guns

International Nuclear Information System (INIS)

Cheng, D.Y.; Tripathi, P.P.; Chang, C.N.

1978-01-01

Deflagration is a process of fluid expansion with energy addition. Its existence in plasma physics was first discovered in the back-strapped T-tube experiments. In the coaxial plasma gun configuration the operation can be simple and yet produce a clean, high density (5 x 10 15 cm -3 ), and high kinetic energy (10 to 50 keV) collimated plasma beam. Plasma acceleration mechanism was thought to be driven by J x B force. Tapered electrodes have been used to obtain plasma beams. Scaling of the gun can be performed according to simple theory based on momentum and energy balance. Proposed plasma fueling and injection to magnetic fusion systems will be discussed

Microstructural stability of heat-resistant high-pressure die-cast Mg-4Al-4Ce alloy

Energy Technology Data Exchange (ETDEWEB)

Wang, Wei; Zhang, Jinghuai; Li, Guoqiang; Feng, Yan; Su, Minliang; Wu, Ruizhi; Zhang, Zhongwu [Harbin Engineering Univ. (China). Key Laboratory of Superlight Material and Surface Technology; Jiao, Yufeng [Jiamusi Univ. (China). College of Materials Science and Engineering

2017-05-15

The thermal stability of Al-RE (rare earth) intermetallic phases with individual RE for heat-resistant high-pressure die-casting Mg-Al-RE alloys is investigated. The results of this study show that the main strengthening phase of Mg-4Al-4Ce alloy is Al{sub 11}Ce{sub 3}, whose content is about 5 wt.% according to quantitative X-ray diffraction phase analysis. The Al{sub 11}Ce{sub 3} phase appears to have high thermal stability at 200 C and 300 C, while phase morphology change with no phase structure transition could occur for Al{sub 11}Ce{sub 3} when the temperature reaches 400 C. Furthermore, besides the kinds of rare earths and temperature, stress is also an influencing factor in the microstructural stability of Mg-4Al-4Ce alloy.

Differences Between New and Long-Standing US Gun Owners: Results From a National Survey.

Science.gov (United States)

Wertz, Joseph; Azrael, Deborah; Hemenway, David; Sorenson, Susan; Miller, Matthew

2018-07-01

To quantify the proportion of current US gun owners who are new to owning firearms and compare new versus long-standing gun owners with respect to their firearms and firearm-related behaviors. We performed a cross-sectional analysis of a nationally representative probability-based online survey conducted in 2015 in the United States. We defined new gun owners as current firearm owners who acquired all of their firearms within the past 5 years, but who lived in a home without a gun at some time over the past 5 years. We defined long-standing firearm owners as all other current gun owners. New gun owners represented 10% of all current US adult gun owners. In addition to being younger than long-standing gun owners, new gun owners were more likely to be liberal, own fewer guns, own handguns, own guns only for protection, and store guns in a safe manner. Gun ownership is dynamic, with approximately 1 million Americans becoming new gun owners each year. Public Health Implications. Clinical guidelines should be updated to explicitly endorse re-evaluating household firearm status at regular intervals.

Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification.

Science.gov (United States)

Dougherty, Edward J; Guo, Chunhua; Simons, S Stoney; Chow, Carson C

2012-01-01

Cofactors are intimately involved in steroid-regulated gene expression. Two critical questions are (1) the steps at which cofactors exert their biological activities and (2) the nature of that activity. Here we show that a new mathematical theory of steroid hormone action can be used to deduce the kinetic properties and reaction sequence position for the functioning of any two cofactors relative to a concentration limiting step (CLS) and to each other. The predictions of the theory, which can be applied using graphical methods similar to those of enzyme kinetics, are validated by obtaining internally consistent data for pair-wise analyses of three cofactors (TIF2, sSMRT, and NCoR) in U2OS cells. The analysis of TIF2 and sSMRT actions on GR-induction of an endogenous gene gave results identical to those with an exogenous reporter. Thus new tools to determine previously unobtainable information about the nature and position of cofactor action in any process displaying first-order Hill plot kinetics are now available.

Cofactor Editing by the G-protein Metallochaperone Domain Regulates the Radical B12 Enzyme IcmF.

Science.gov (United States)

Li, Zhu; Kitanishi, Kenichi; Twahir, Umar T; Cracan, Valentin; Chapman, Derrell; Warncke, Kurt; Banerjee, Ruma

2017-03-10

IcmF is a 5'-deoxyadenosylcobalamin (AdoCbl)-dependent enzyme that catalyzes the carbon skeleton rearrangement of isobutyryl-CoA to butyryl-CoA. It is a bifunctional protein resulting from the fusion of a G-protein chaperone with GTPase activity and the cofactor- and substrate-binding mutase domains with isomerase activity. IcmF is prone to inactivation during catalytic turnover, thus setting up its dependence on a cofactor repair system. Herein, we demonstrate that the GTPase activity of IcmF powers the ejection of the inactive cob(II)alamin cofactor and requires the presence of an acceptor protein, adenosyltransferase, for receiving it. Adenosyltransferase in turn converts cob(II)alamin to AdoCbl in the presence of ATP and a reductant. The repaired cofactor is then reloaded onto IcmF in a GTPase-gated step. The mechanistic details of cofactor loading and offloading from the AdoCbl-dependent IcmF are distinct from those of the better characterized and homologous methylmalonyl-CoA mutase/G-protein chaperone system. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Gun policy and serious mental illness: priorities for future research and policy.

Science.gov (United States)

McGinty, Emma Elizabeth; Webster, Daniel W; Barry, Colleen L

2014-01-01

In response to recent mass shootings, policy makers have proposed multiple policies to prevent persons with serious mental illness from having guns. The political debate about these proposals is often uninformed by research. To address this gap, this review article summarizes the research related to gun restriction policies that focus on serious mental illness. Gun restriction policies were identified by researching the THOMAS legislative database, state legislative databases, prior review articles, and the news media. PubMed, PsycINFO, and Web of Science databases were searched for publications between 1970 and 2013 that addressed the relationship between serious mental illness and violence, the effectiveness of gun policies focused on serious mental illness, the potential for such policies to exacerbate negative public attitudes, and the potential for gun restriction policies to deter mental health treatment seeking. Limited research suggests that federal law restricting gun possession by persons with serious mental illness may prevent gun violence from this population. Promotion of policies to prevent persons with serious mental illness from having guns does not seem to exacerbate negative public attitudes toward this group. Little is known about how restricting gun possession among persons with serious mental illness affects suicide risk or mental health treatment seeking. Future studies should examine how gun restriction policies for serious mental illness affect suicide, how such policies are implemented by states, how persons with serious mental illness perceive policies that restrict their possession of guns, and how gun restriction policies influence mental health treatment seeking among persons with serious mental illness.

Synthesis and characterization of sulfur-voided cubanes. Structural analogues for the MoFe(3)S(3) subunit in the nitrogenase cofactor.

Science.gov (United States)

Coucouvanis, Dimitri; Han, Jaehong; Moon, Namdoo

2002-01-16

A new class of Mo/Fe/S clusters with the MoFe(3)S(3) core has been synthesized in attempts to model the FeMo-cofactor in nitrogenase. These clusters are obtained in reactions of the (Cl(4)-cat)(2)Mo(2)Fe(6)S(8)(PR(3))(6) [R = Et (I), (n)Pr (II)] clusters with CO. The new clusters include those preliminarily reported: (Cl(4)-cat)MoFe(3)S(3)(PEt(3))(2)(CO)(6) (III), (Cl(4)-cat)(O)MoFe(3)S(3)(PEt(3))(3)(CO)(5) (IV), (Cl(4)-cat)(Pyr)MoFe(3)S(3)(PEt(3))(2)(CO)(6) (VI), and (Cl(4)-cat)(Pyr)MoFe(3)S(3)(P(n)Pr(3))(3)(CO)(4) (VIII). In addition the new (Cl(4)-cat)(O)MoFe(3)S(3)(P(n)Pr(3))(3)(CO)(5) cluster (IVa), the (Cl(4)-cat)(O)MoFe(3)S(3)(PEt(3))(2)(CO)(6)cluster (V), the (Cl(4)-cat)(O)MoFe(3)S(3)(P(n)Pr(3))(2)(CO)(6) cluster (Va), the (Cl(4)-cat)(Pyr)MoFe(3)S(3)(P(n)Pr(3))(2)(CO)(6) cluster (VIa), and the (Cl(4)-cat)(P(n)Pr(3))MoFe(3)S(3)(P(n)Pr(3))(2)(CO)(6) cluster (VII) also are reported. Clusters III-VIII have been structurally and spectroscopically characterized. EPR, zero-field (57)Fe-Mössbauer spectroscopic characterizations, and magnetic susceptibility measurements have been used for a tentative assignment of the electronic and oxidation states of the MoFe(3)S(3) sulfur-voided cuboidal clusters. A structural comparison of the clusters with the MoFe(3)S(3) subunit of the FeMo-cofactor has led to the suggestion that the storage of reducing equivalents into M-M bonds, and their use in the reduction of substrates, may occur with the FeMo-cofactor, which also appears to have M-M bonding. On the basis of this argument, a possible N(2)-binding and reduction mechanism on the FeMoco-cofactor is proposed.

The electrical Discharge Characteristics of the 3.5 KJ Electrothermal Plasma Gun Experiment

International Nuclear Information System (INIS)

Diab, F.; El-Aragi, G.M.; El-Kashef, G.M.; Saudy, A.H.

2013-01-01

In order to better understand the operating characteristics of an electrothermal plasma gun and its design, a variety of operation characteristics including ( the length of the capillary, applied voltage, diameter of the capillary tube, circuit inductance) were investigated to determine performance effects and viability in a real system. An Electrothermal Plasma Gun (ETG) is composed of a capillary discharge tube made of Teflon operated with simple RLC circuit. The device called Electrothermal Gun (ETG) which is composed of 4 capacitors (70 μF, 10 kV, 1.3 μH) connected in parallel to a plasma source by means of one high power plane transmission line by mean of a switch triggered by negative pulse 360/385 V. For the present studies a simple RLC was chosen, which allowed the circuit parameters to be easily measure d. The electrothermal discharge characteristics of the plasma gun operated in open air, So that at atmospheric pressure the main parameters were measured. The gun voltage and discharge current are measured with voltage divider and Rogowiski coil respectively. From the results recorded we found that, the current lagged the voltage i-e the plasma source has an inductive reactivity. Moreover, the current value was changed by changing the circuit parameters, including the discharge voltage and circuit inductance, and the wire properties such as the length and diameter. The maximum gun current ranged between (5 - 50 KA) according to the charging voltage of capacitors between (1-7 KV), a typical discharge times are on the order r of 125 μS.

Characterization of the C-2W Plasma Guns

Science.gov (United States)

Dubois, Ami; Sokolov, Vladimir; Korepanov, Sergey; Osin, Dima; Player, Gabriel; TAE Team

2017-10-01

Previous use of coaxial arc discharge plasma guns on the C-2U device exhibited great success in plasma stabilization and improved confinement. On the C-2W experiment, arc discharge plasma guns will again be used to facilitate the electrical connection between the plasma core and the divertor electrodes in order to maintain the electrode edge biasing and induce E x B shear to control plasma rotation. Each plasma gun contains an internal solenoid used to shape the plasma stream. Characterization of electron density (ne) , electron temperature (Te) , floating potential (Vf) , and total plasma flux in an arc discharge lasting 6 ms without the internal solenoid are presented. A Langmuir probe located 27 cm axially outside of the plasma gun anode measures a bell-like radial ne profile with peak ne 1018 m-3 and Te 2 - 10 eV. Observed spectral lines of impurity ions provide an estimate of Te, and Balmer series line ratios of the main ion component are used to evaluate ne at both the probe location and near the plasma gun anode. A calorimeter measures the plasma flux to be constant and equivalent to 1 kA.

Guns and Fear: A One-Way Street?

Science.gov (United States)

Hauser, Will; Kleck, Gary

2013-01-01

Surveys show that more than one half of gun owners report owning their firearm for self-protection. Although research has examined the effect of fear of crime on gun ownership, the issue of reciprocity and temporal order has been largely ignored. Furthermore, the effect of firearm acquisition and relinquishment on fear has not been evaluated…

Gun Violence and Children: Factors Related To Exposure and Trauma.

Science.gov (United States)

Slovak, Karen

2002-01-01

Study investigated relationship between access to firearms and parental monitoring on rural youths' exposure to gun violence, and examined the effect of gun violence exposure on mental health. Results indicated a substantial number were exposed to gun violence. Exposure was related to firearm access and parental monitoring. Implications for social…

Analysis on a electron gun for metal fusion

International Nuclear Information System (INIS)

Paes, A.C.J.; Galvao, R.M.O.; Boscolo, P.; Passaro, A.

1987-09-01

The characteristics of the electron beam of the HK-011600 Δ, electron gun for metal fusion at the 'Divisao de Materiais do Instituto de Pesquisa e Desenvolvimento do CTA (PMR/IPD/CTA)', is analyzed. In this analysis, the Pierce gun model and the SLAC computational code for electron optics are used. The electron beam R and Z profiles are obtained in the gun region and in the magnetic lenses region. The behaviour of the electron beam in the prism region is also discussed using a simple model. (author) [pt

Method of electron emission control in RF guns

International Nuclear Information System (INIS)

Khodak, I.V.; Kushnir, V.A.

2001-01-01

The electron emission control method for a RF gun is considered.According to the main idea of the method,the additional resonance system is created in a cathode region where the RF field strength could be varied using the external pulse equipment. The additional resonance system is composed of a coaxial cavity coupled with a RF gun cylindrical cavity via an axial hole. Computed results of radiofrequency and electrodynamic performances of such a two-cavity system and results of the RF gun model pilot study are presented in. Results of particle dynamics simulation are described

Method of electron emission control in RF guns

CERN Document Server

Khodak, I V

2001-01-01

The electron emission control method for a RF gun is considered.According to the main idea of the method,the additional resonance system is created in a cathode region where the RF field strength could be varied using the external pulse equipment. The additional resonance system is composed of a coaxial cavity coupled with a RF gun cylindrical cavity via an axial hole. Computed results of radiofrequency and electrodynamic performances of such a two-cavity system and results of the RF gun model pilot study are presented in. Results of particle dynamics simulation are described.

Non-channel magnetron gun as the electron source for resonance linear accelerator

International Nuclear Information System (INIS)

Ivanov, G.M.; Makhnenko, L.A.; Cherenshchikov, S.A.

1999-01-01

Studies on the magnetron gun with a cold cathode being part of linear accelerator on the travelling wave are described. Two modes of the gun operation differing by presence of UHF field of the pre-buncher near the gun are observed. In the mode without UHF field the short (about 2 ns) pulses of accelerated electrons with amplitude up to 0.5 A at the gun current up to 20 A were obtained. The presence of UHF field near the gun makes it possible to obtain the beam of higher duration (up to 1.0 μs), but with current up to 20 mA at the accelerator outlet and up to 1 A at the gun outlet. The mechanism of the gun operation is concerned with the secondary-electron current increase and setting self-sustaining secondary emission. Gun characteristics under study are acceptable for the purposes of injection into accelerator [ru

Performance of photocathode rf gun electron accelerators

International Nuclear Information System (INIS)

Ben-Zvi, I.

1993-01-01

In Photo-Injectors (PI) electron guns, electrons are emitted from a photocathode by a short laser pulse and then accelerated by intense rf fields in a resonant cavity. The best known advantage of this technique is the high peak current with a good emittance (high brightness). This is important for short wavelength Free-Electron Lasers and linear colliders. PIs are in operation in many electron accelerator facilities and a large number of new guns are under construction. Some applications have emerged, providing, for example, very high pulse charges. PIs have been operated over a wide range of frequencies, from 144 to 3000 MHz (a 17 GHz gun is being developed). An exciting new possibility is the development of superconducting PIs. A significant body of experimental and theoretical work exists by now, indicating the criticality of the accelerator elements that follow the gun for the preservation of the PI's performance as well as possible avenues of improvements in brightness. Considerable research is being done on the laser and photocathode material of the PI, and improvement is expected in this area

Modifications Of A Commercial Spray Gun

Science.gov (United States)

Allen, Peter B.

1993-01-01

Commercial spray gun modified to increase spray rate and make sprayed coats more nearly uniform. Consists of gun head and pneumatic actuator. Actuator opens valves for two chemical components, called "A" and "B," that react to produce foam. Components flow through orifices, into mixing chamber in head. Mixture then flows through control orifice to spray tip. New spray tip tapered to reduce area available for accumulation of foam and makes tip easier to clean.

Progress on Using NEA Cathodes in an RF Gun

CERN Document Server

Fliller, Raymond P; Blüm, Hans; Edwards, Helen; Hüning, Markus; Schultheiss, Tom; Sinclair, Charles K

2005-01-01

RF guns have proven useful in multiple accelerator applications, and are an attractive electron source for the ILC. Using a NEA GaAs photocathode in such a gun allows for the production of polarized electron beams. However the lifetime of a NEA cathode in this environment is reduced by ion and electron bombardment and residual gas oxidation. We report progress made with studies to produce a RF gun using a NEA GaAs photocathode to produce polarized electron beams. Attempts to reduce the residual gas pressure in the gun are discussed. Initial measurements of ion flux through the cathode port are compared with simulations of ion bombardment. Future directions are also discussed.

DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes

Science.gov (United States)

Cruz-Reyes, Jorge; Mooers, Blaine H.M.; Abu-Adas, Zakaria; Kumar, Vikas; Gulati, Shelly

2016-01-01

Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100–400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans. PMID:27540585

Technological guns which form the profiled electron beans

International Nuclear Information System (INIS)

Mel'nik, V.I.

1998-01-01

Electron guns with high-voltage glow discharge are developed which form disc - and tubule-like,hollow conic and linear electron beams,as well as devices and systems for control of gun parameter and technological processes in low and intermediate vacuum

The breakdown phase in a coaxial plasma gun

International Nuclear Information System (INIS)

Donges, A.; Herziger, G.; Krompholz, H.; Ruehl, F.; Schoenbach, K.

1980-01-01

The electrical breakdown in a coaxial plasma gun was investigated by means of optical and electrical measurements. The optimum start and operation conditions of the gun turned out to be strongly dependent on material and length of the cylindrical insulator. (orig.)

Characterization of a dielectric barrier plasma gun discharging at atmospheric pressure

International Nuclear Information System (INIS)

Zhang Guangqiu; Ge Yuanjing; Zhang Yuefei; Chen Guangliang

2004-01-01

The authors develop a plasma gun based on dielectric barrier discharge and working at atmospheric pressure. A theoretical model to predict the gun discharge voltage is built, which is in agreement with the experimental results. After investigating the characterization of discharging gun and utilizing it for polymerization, authors find that the gun can be used as a source to generate a stable uniform plasma for different plasma-processing technologies. (author)

Development of laser heated high current DC electron gun

International Nuclear Information System (INIS)

Banerjee, Srutarshi; Bhattacharjee, Dhruva; Kandaswamy, E.; Ghodke, S.R.; Tiwari, Rajnish; Bakhtsingh, R.I.

2015-01-01

The paper deals with the development of a Laser heated cathode for Electron Accelerator. The electron gun is meant for Megawatt-class DC Accelerator for Electron Beam Flue Gas Treatment applications. Conventionally, LaB 6 cathode is indirectly heated by tungsten filaments whereas in the newly proposed gun, Laser is utilized for heating. A Nd:YAG Laser is used to heat the LaB 6 cathode to emission temperatures. The characterization of cathode heating at various Laser powers has been carried out. In initial trials, it has been observed that with 125 W of Laser power, the LaB 6 pellet was heated to 1315 ° C. Based on these experimental results, an electron gun rated for 30 kV, 350 mA CW has been designed. The optimization of gun electrode geometry has been done using CST Particle Studio in order to tune the various electron gun parameters. The beam diameter obtained in simulation is 8 mm at 100 mm from the LaB 6 cathode. The perveance obtained is 7.1 x 10 -8 A/V 3/2 . The Laser heated cathode has the advantages of eliminating the magnetic field effects of filament on the electron beam, electrical isolation needed for gun filament power supplies and better electron beam emittances. (author)

Solid-liquid stable phase equilibria of the ternary systems MgCl2 + MgB6O10+ H2O AND MgSO4 + MgB6O10 + H2O at 308.15 K

Directory of Open Access Journals (Sweden)

Lingzong Meng

2014-03-01

Full Text Available The solubilities and the relevant physicochemical properties of the ternary systems MgCl2 + MgB6O10 + H2O and MgSO4 + MgB6O10 + H2O at 308.15 K were investigated using an isothermal dissolution method. It was found that there is one invariant point, two univariant curves, and two crystallization regions of the systems. The systems belong to a simple co-saturated type, and neither double salts nor solid solutions were found. Based on the extended HW model and its temperature-dependent equations, the single-salt Pitzer parameters β(0, β(1, β(2 and CØ for MgCl2, MgSO4, and Mg(B6O7(OH6, the mixed ion-interaction parameters θCl,B6O10, θSO4,B6O10, ΨMg,Cl,B6O10, ΨMg,SO4,B6O10 of the systems at 308.15 K were fitted, In addition, the average equilibrium constants of the stable equilibrium solids at 308.15 K were obtained by a method using the activity product constant. Then the solubilities of the ternary systems are calculated. The calculated solubilities agree well with the experimental values.

Emission spectra of phosphor MgSO4 doped with Dy and Mn

International Nuclear Information System (INIS)

Zhang Chunxiang; Chen Lixin; Tang Qiang; Luo Daling; Qiu Zhiren

2001-01-01

Emission spectra of phosphor MgSO 4 doped with Dy and Dy/Mn were measured with an optical multichannel analyzer and a linear heating system whose temperature was controlled by a microcomputer. The emission spectrum bands at 480 nm and 580 nm of phosphor MgSO 4 doped with Dy were observed in the three dimensional (3D) glow curves. Compared with the 3D spectrum of CaSO 4 :Dy and the spectrum bands of MgSO 4 :Dy shows the same wavelengths which resulted from the quantum transitions among the energy levels of Dy 3 '+ ions. The intensities of the glow peaks in both spectrum bands (480 nm and 580 nm) of phosphor MgSO 4 doped with Dy/Mn were dramatically reduced except the 380 degree C glow peak

Operating characteristics and modeling of the LLNL 100-kV electric gun

International Nuclear Information System (INIS)

Osher, J.E.; Barnes, G.; Chau, H.H.; Lee, R.S.; Lee, C.; Speer, R.; Weingart, R.C.

1989-01-01

In the electric gun, the explosion of an electrically heated metal foil and the accompanying magnetic forces drive a thin flyer plate up a short barrel. Flyer velocities of up to 18 km/s make the gun useful for hypervelocity impact studies. The authors briefly review the technological evolution of the exploding-metal circuit elements that power the gun, describe the 100-kV electric gun designed at Lawrence Livermore National Laboratory (LLNL) in some detail, and present the general principles of electric gun operation. They compare the experimental performance of the LLNL gun with a simple model and with predictions of a magnetohydrodynamics code

Coaxial plasma guns as injectors of high beta linear theta pinches

International Nuclear Information System (INIS)

Marshall, J.

1975-01-01

A brief review of research on coaxial plasma guns and their use is given. Some problems and possibilities of using this gun for beam injection experiments are pointed out. Some scaling laws for gun energy are described

American preferences for “smart” guns versus traditional weapons: Results from a nationwide survey

Directory of Open Access Journals (Sweden)

Lacey Nicole Wallace

2016-12-01

Full Text Available This study examines Americans' preferences regarding smart guns. The study builds on prior research by including previously unexamined factors, specifically victimization and comfort sharing gun ownership status with a doctor. Further, this study examines differences in preference patterns among gun owners and non-owners. Data were obtained from a nationwide online survey with 524 respondents in February 2016. The study finds that, among non-owners, older respondents and those with pro-gun attitudes are less likely to prefer smart guns to traditional firearms. Among gun owners, those with moderate political views, those with a history of victimization, and those residing in the Northeast are all more likely to prefer smart guns. Males and those with pro-gun attitudes are less likely to prefer smart guns. Education, income, race, marital status, presence of children in the home, and comfort discussing gun ownership with a doctor had no significant association with smart gun preference. Practical implications of these findings are discussed.

Should Gun Safety Be Taught in Schools? Perspectives of Teachers

Science.gov (United States)

Obeng, Cecilia

2010-01-01

Background: Gun-related injuries and deaths among children occur at disproportionately high rates in the United States. Children who live in homes with guns are the most likely victims. This study describes teachers' views on whether gun safety should be taught to children in the preschool and elementary years. Methods: A total of 150 survey…

Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers EVIDENCE FOR A DIRECT PATHWAY BETWEEN THE 4′-AMINOPYRIMIDINE N1′ ATOMS

Energy Technology Data Exchange (ETDEWEB)

Nemeria, Natalia S; Arjunan, Palaniappa; Chandrasekhar, Krishnamoorthy; Mossad, Madouna; Tittmann, Kai; Furey, William; Jordan, Frank [Pitt; (Goettingen); (VA); (Rutgers)

2010-11-03

Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4{prime}-aminopyrimidine N1{prime} atoms of thiamin diphosphates (ThDPs) in the two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a signal transduction pathway. Substitution of the three acidic residues (Glu{sup 571}, Glu{sup 235}, and Glu{sup 237}) and Arg{sup 606} resulted in impaired binding of the second ThDP, once the first active center was filled, suggesting a pathway for communication between the two ThDPs. (1) Steady-state kinetic and fluorescence quenching studies revealed that upon E571A, E235A, E237A, and R606A substitutions, ThDP binding in the second active center was affected. (2) Analysis of the kinetics of thiazolium C2 hydrogen/deuterium exchange of enzyme-bound ThDP suggests half-of-the-sites reactivity for the E1 component, with fast (activated site) and slow exchanging sites (dormant site). The E235A and E571A variants gave no evidence for the slow exchanging site, indicating that only one of two active sites is filled with ThDP. (3) Titration of the E235A and E237A variants with methyl acetylphosphonate monitored by circular dichroism suggested that only half of the active sites were filled with a covalent predecarboxylation intermediate analog. (4) Crystal structures of E235A and E571A in complex with ThDP revealed the structural basis for the spectroscopic and kinetic observations and showed that either substitution affects cofactor binding, despite the fact that Glu{sup 235} makes no direct contact with the cofactor. The role of the conserved Glu{sup 571} residue in both catalysis and cofactor orientation is revealed by the combined results for the first time.

Combustion of Na2B4O7 + Mg + C to synthesis B4C powders

International Nuclear Information System (INIS)

Jiang Guojian; Xu Jiayue; Zhuang Hanrui; Li Wenlan

2009-01-01

Boron carbide powder was fabricated by combustion synthesis (CS) method directly from mixed powders of borax (Na 2 B 4 O 7 ), magnesium (Mg) and carbon. The adiabatic temperature of the combustion reaction of Na 2 B 4 O 7 + 6 Mg + C was calculated. The control of the reactions was achieved by selecting reactant composition, relative density of powder compact and gas pressure in CS reactor. The effects of these different influential factors on the composition and morphologies of combustion products were investigated. The results show that, it is advantageous for more Mg/Na 2 B 4 O 7 than stoichiometric ratio in Na 2 B 4 O 7 + Mg + C system and high atmosphere pressure in the CS reactor to increase the conversion degree of reactants to end product. The final product with the minimal impurities' content could be fabricated at appropriate relative density of powder compact. At last, boron carbide without impurities could be obtained after the acid enrichment and distilled water washing.

Wetting of B4C, TiC and graphite substrates by molten Mg

International Nuclear Information System (INIS)

Zhang Dan; Shen Ping; Shi Laixin; Jiang Qichuan

2011-01-01

Highlights: → The wettability of TiC, B4C and C by molten Mg was determined using an improved sessile drop method. → A new method to evaluate the wetting behavior coupled with evaporation and reaction was proposed. → The bonding characteristics in the Mg/B4C, Mg/TiC and Mg/graphite systems were evaluated. - Abstract: The isotherm wetting of B 4 C, TiC and graphite substrates by molten Mg was studied in a flowing Ar atmosphere at 973-1173 K using an improved sessile drop method. The initial contact angles are in the ranges of 95-87 deg., 74-60 deg. and 142-124 deg., respectively, moderately depending on the temperature. All the systems are non-reactive in nature; however, the presence of impurity of free boron at the B 4 C surface gave rise to the chemical reaction with molten Mg and thus promoted the wettability to a certain degree. A new method was proposed to evaluate the wetting behavior coupled with evaporation and chemical reaction. Furthermore, based on the comparison of the work of adhesion and cohesion, the bonding in the Mg/B 4 C and Mg/TiC systems is presumably mainly chemical while that in the Mg/graphite system is physical.

High Brightness Electron Guns for Next-Generation Light Sources and Accelerators

International Nuclear Information System (INIS)

H. Bluem; M.D. Cole; J. Rathke; T. Schultheiss; A.M.M. Todd; I. Ben-Zvi; T. Srinivasan-Rao; P. Colestock; D.C. Nguyen; R.L. Wood; L. Young; D. Janssen; J. Lewellen; G. Neil; H.L. Phillips; J.P. Preble

2004-01-01

Advanced Energy Systems continues to develop advanced electron gun and injector concepts. Several of these projects have been previously described, but the progress and status of each will be updated. The project closest to completion is an all superconducting RF (SRF) gun, being developed in collaboration with the Brookhaven National Laboratory, that uses the niobium of the cavity wall itself as the photocathode material. This gun has been fabricated and will shortly be tested with beam. The cavity string for a closely-coupled DC gun and SRF cavity injector that is expected to provide beam quality sufficient for proposed ERL light sources and FELs will be assembled at the Jefferson Laboratory later this year. We are also collaboration with Los Alamos on a prototype CW normal-conducting RF gun with similar performance, that will undergo thermal testing in late 2004. Another CW SRF gun project that uses a high quantum efficiency photocathode, similar to the FZ-Rossendorf approach, has just begun. Finally, we will present the RF design and cold test results for a fully axisymmetric, ultra-high-brightness x-band RF gun

Design of e-gun for large KrF amplifiers

International Nuclear Information System (INIS)

Reilly, D.A.; Von Rosenberg, C.W.

1985-01-01

The design of very large single-aperture laser amplifier for an angular multiplexed laser fusion system requires advances in excimer laser e-gun technology beyond existing designs. Scaling considerations dictate the use of multiple e-guns to pump a single laser; in the present case the authors will discuss the scaling and design features of one of the ten e-guns being developed to pump the Los Alamos Polaris Power Amplifier Module. Multiple e-guns minimize the diode self-magnetic field, lowering the size of the imposed guide magnetic field, and reducing the diode impendance collapse. Multiple guns also result in lowered current rise times, reduce the development cost of the technology at the prototype stage, and, of course, limit the cost due to operation failures in the e-gun. The present design utilizes the expanding electron flow diode to provide uniform electron flow into the gas from a high-current density cold cathode (approx. =50 A/cm 2 ). Laminated iron and an imposed dipole field are utilized for B-field shaping. The applied B field lines trace from the anode, terminate on the cathode, and are then conducted through the shank to beyond the bushing. This feature not only provides for fully expanded electron flow from cathode to anode, but it also allows for self-magnetic field insulation of the shank and bushing, thus minimizing voltage standoff distances, inductance, and rise time. A single large aspect ratio racetrack-shaped bushing on each e-gun is provided with robust grading to limit field concentration at the ends

Proteolytic cleavage orchestrates cofactor insertion and protein assembly in [NiFe]-hydrogenase biosynthesis.

Science.gov (United States)

Senger, Moritz; Stripp, Sven T; Soboh, Basem

2017-07-14

Metalloenzymes catalyze complex and essential processes, such as photosynthesis, respiration, and nitrogen fixation. For example, bacteria and archaea use [NiFe]-hydrogenases to catalyze the uptake and release of molecular hydrogen (H 2 ). [NiFe]-hydrogenases are redox enzymes composed of a large subunit that harbors a NiFe(CN) 2 CO metallo-center and a small subunit with three iron-sulfur clusters. The large subunit is synthesized with a C-terminal extension, cleaved off by a specific endopeptidase during maturation. The exact role of the C-terminal extension has remained elusive; however, cleavage takes place exclusively after assembly of the [NiFe]-cofactor and before large and small subunits form the catalytically active heterodimer. To unravel the functional role of the C-terminal extension, we used an enzymatic in vitro maturation assay that allows synthesizing functional [NiFe]-hydrogenase-2 of Escherichia coli from purified components. The maturation process included formation and insertion of the NiFe(CN) 2 CO cofactor into the large subunit, endoproteolytic cleavage of the C-terminal extension, and dimerization with the small subunit. Biochemical and spectroscopic analysis indicated that the C-terminal extension of the large subunit is essential for recognition by the maturation machinery. Only upon completion of cofactor insertion was removal of the C-terminal extension observed. Our results indicate that endoproteolytic cleavage is a central checkpoint in the maturation process. Here, cleavage temporally orchestrates cofactor insertion and protein assembly and ensures that only cofactor-containing protein can continue along the assembly line toward functional [NiFe]-hydrogenase. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

The Effect of Child Access Prevention Laws on Non-Fatal Gun Injuries

OpenAIRE

Jeff DeSimone; Sara Markowitz

2005-01-01

Many states have passed child access prevention (CAP) laws, which hold the gun owner responsible if a child gains access to a gun that is not securely stored. Previous CAP law research has focused exclusively on gun-related deaths even though most gun injuries are not fatal. We use annual hospital discharge data from 1988-2001 to investigate whether CAP laws decrease non-fatal gun injuries. Results from Poisson regressions that control for various hospital, county and state characteristics, i...

Controlled and spontaneous magnetic field generation in a gun-driven spheromak

International Nuclear Information System (INIS)

Woodruff, S.; Cohen, B.I.; Hooper, E.B.; Mclean, H.S.; Stallard, B.W.; Hill, D.N.; Holcomb, C.T.; Romero-Talamas, C.; Wood, R.D.; Cone, G.; Sovinec, C.R.

2005-01-01

In the Sustained Spheromak Physics Experiment, SSPX [E. B. Hooper, D. Pearlstein, and D. D. Ryutov, Nucl. Fusion 39, 863 (1999)], progress has been made in understanding the mechanisms that generate fields by helicity injection. SSPX injects helicity (linked magnetic flux) from 1 m diameter magnetized coaxial electrodes into a flux-conserving confinement region. Control of magnetic fluctuations (δB/B∼1% on the midplane edge) yields T e profiles peaked at >200 eV. Trends indicate a limiting beta (β e ∼4%-6%), and so we have been motivated to increase T e by operating with stronger magnetic field. Two new operating modes are observed to increase the magnetic field: (A) Operation with constant current and spontaneous gun voltage fluctuations. In this case, the gun is operated continuously at the threshold for ejection of plasma from the gun: stored magnetic energy of the spheromak increases gradually with δB/B∼2% and large voltage fluctuations (δV∼1 kV), giving a 50% increase in current amplification, I tor /I gun . (B) Operation with controlled current pulses. In this case, spheromak magnetic energy increases in a stepwise fashion by pulsing the gun, giving the highest magnetic fields observed for SSPX (∼0.7 T along the geometric axis). By increasing the time between pulses, a quasisteady sustainment is produced (with periodic good confinement), comparing well with resistive magnetohydrodynamic simulations. In each case, the processes that transport the helicity into the spheromak are inductive and exhibit a scaling of field with current that exceeds those previously obtained. We use our newly found scaling to suggest how to achieve higher temperatures with a series of pulses

Controlled and Spontaneous Magnetic Field Generation in a Gun-Driven Spheromak

International Nuclear Information System (INIS)

Woodruff, S; Cohen, B I; Hooper, E B; McLean, H S; Stallard, B W; Hill, D N; Holcomb, C T; Romero-Talamas, C; Wood, R D; Cone, G; Sovinec, C R

2005-04-01

In the Sustained Spheromak Physics Experiment, SSPX, progress has been made in understanding the mechanisms that generate fields by helicity injection. SSPX injects helicity (linked magnetic flux) from 1-m diameter magnetized coaxial electrodes into a flux-conserving confinement region. Control of magnetic fluctuations ((delta)B/B∼1% on the midplane edge) yields T e profiles peaked at > 200eV. Trends indicate a limiting beta (β e ∼ 4-6%), and so we have been motivated to increase T e by operating with stronger magnetic field. Two new operating modes are observed to increase the magnetic field: (A) Operation with constant current and spontaneous gun voltage fluctuations. In this case, the gun is operated continuously at the threshold for ejection of plasma from the gun: stored magnetic energy of the spheromak increases gradually with (delta)B/B ∼2% and large voltage fluctuations ((delta)V ∼ 1kV), giving a 50% increase in current amplification, I tor /I gun . (B) Operation with controlled current pulses. In this case, spheromak magnetic energy increases in a stepwise fashion by pulsing the gun, giving the highest magnetic fields observed for SSPX (∼0.7T along the geometric axis). By increasing the time between pulses, a quasi-steady sustainment is produced (with periodic good confinement), comparing well with resistive MHD simulations. In each case, the processes that transport the helicity into the spheromak are inductive and exhibit a scaling of field with current that exceeds those previously obtained. We use our newly found scaling to suggest how to achieve higher temperatures with a series of pulses

State Firearm Laws and Interstate Transfer of Guns in the USA, 2006-2016.

Science.gov (United States)

Collins, Tessa; Greenberg, Rachael; Siegel, Michael; Xuan, Ziming; Rothman, Emily F; Cronin, Shea W; Hemenway, David

2018-06-01

In a cross-sectional, panel study, we examined the relationship between state firearm laws and the extent of interstate transfer of guns, as measured by the percentage of crime guns recovered in a state and traced to an in-state source (as opposed to guns recovered in a state and traced to an out-of-state source). We used 2006-2016 data on state firearm laws obtained from a search of selected state statutes and 2006-2016 crime gun trace data from the Bureau of Alcohol, Tobacco, Firearms, and Explosives. We examined the relationship between state firearm laws and interstate transfer of guns using annual data from all 50 states during the period 2006-2016 and employing a two-way fixed effects model. The primary outcome variable was the percentage of crime guns recovered in a state that could be traced to an original point of purchase within that state as opposed to another state. The main exposure variables were eight specific state firearm laws pertaining to dealer licensing, sales restrictions, background checks, registration, prohibitors for firearm purchase, and straw purchase of guns. Four laws were independently associated with a significantly lower percentage of in-state guns: a waiting period for handgun purchase, permits required for firearm purchase, prohibition of firearm possession by people convicted of a violent misdemeanor, and a requirement for relinquishment of firearms when a person becomes disqualified from owning them. States with a higher number of gun laws had a lower percentage of traced guns to in-state dealers, with each increase of one in the total number of laws associated with a decrease of 1.6 percentage points in the proportion of recovered guns that were traced to an in-state as opposed to an out-of-state source. Based on an examination of the movement patterns of guns across states, the overall observed pattern of gun flow was out of states with weak gun laws and into states with strong gun laws. These findings indicate that certain

Magnesium Aminoclay-Fe3O4 (MgAC-Fe3O4 Hybrid Composites for Harvesting of Mixed Microalgae

Directory of Open Access Journals (Sweden)

Bohwa Kim

2018-05-01

Full Text Available In this paper, we describe the synthesis of magnesium aminoclay-iron oxide (MgAC-Fe3O4 hybrid composites for microalgae-harvesting application. MgAC-templated Fe3O4 nanoparticles (NPs were synthesized in different ratios of MgAC and Fe3O4 NPs. The uniform distribution of Fe3O4 NPs in the MgAC matrix was confirmed by transmission electron microscopy (TEM. According to obtained X-ray diffraction (XRD patterns, increased MgAC loading leads to decreased intensity of the composites’ (311 plane of Fe3O4 NPs. For harvesting of Chlorella sp. KR-1, Scenedesmus obliquus and mixed microalgae (Chlorella sp. KR-1/ Scenedesmus obliquus, the optimal pH was 4.0. At higher pHs, the microalgae-harvesting efficiencies fell. Sample #1, which had the highest MgAC concentration, showed the most stability: the harvesting efficiencies for Chlorella sp. KR-1, Scenedesmus obliquus, and mixed microalgae were reduced only to ~50% at pH = 10.0. The electrostatic interaction between MgAC and the Fe3O4 NPs in the hybrid samples by microalgae, as confirmed by zeta potential measurements, were attributed to the harvesting mechanisms. Moreover, the zeta potentials of the MgAC-Fe3O4 hybrid composites were reduced as pH was increased, thus diminishing the microalgae-harvesting efficiencies.

Examining the relationship between the prevalence of guns and homicide rates in the USA using a new and improved state-level gun ownership proxy.

Science.gov (United States)

Siegel, Michael; Ross, Craig S; King, Charles

2014-12-01

Determining the relationship between gun ownership levels and firearm homicide rates is critical to inform public health policy. Previous research has shown that state-level gun ownership, as measured by a widely used proxy, is positively associated with firearm homicide rates. A newly developed proxy measure that incorporates the hunting license rate in addition to the proportion of firearm suicides correlates more highly with state-level gun ownership. To corroborate previous research, we used this new proxy to estimate the association of state-level gun ownership with total, firearm, and non-firearm homicides. Using state-specific data for the years 1981-2010, we modelled these rates as a function of gun ownership level, controlling for potential confounding factors. We used a negative binomial regression model and accounted for clustering of observations among states. We found that state-level gun ownership as measured by the new proxy, is significantly associated with firearm and total homicides but not with non-firearm homicides. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Thermal and mechanical study of a MIG-type electron gun for a 31 GHz, 100 k W gyrotron

International Nuclear Information System (INIS)

Patire Junior, H.; Barroso, J.J.

1994-01-01

A thermal and mechanical study of a MIG-type electron gun has been made to determine the temperature distribution in all the gun elements as a function of the input heater power. Appropriate materials were selected to minimize both the conduction and radiation thermal losses. The electron emitting surface operates at an average temperature of 1000 0 C with 374 W input power in the heating filament system. The purpose of the present study is to reduce the input heater power while keeping the required operating cathode temperature and to improve the gun design from a constructional point of view aiming at extending the capabilities of the electron gun. A thermal software has been used by considering the operation conditions taking into account external convection by forced air and thermal radiation transfer between the electrodes of the gun. (author). 5 refs, 4 figs, 1 tab

Spatio-temporal patterns of gun violence in Syracuse, New York 2009-2015.

Science.gov (United States)

Larsen, David A; Lane, Sandra; Jennings-Bey, Timothy; Haygood-El, Arnett; Brundage, Kim; Rubinstein, Robert A

2017-01-01

Gun violence in the United States of America is a large public health problem that disproportionately affects urban areas. The epidemiology of gun violence reflects various aspects of an infectious disease including spatial and temporal clustering. We examined the spatial and temporal trends of gun violence in Syracuse, New York, a city of 145,000. We used a spatial scan statistic to reveal spatio-temporal clusters of gunshots investigated and corroborated by Syracuse City Police Department for the years 2009-2015. We also examined predictors of areas with increased gun violence using a multi-level zero-inflated Poisson regression with data from the 2010 census. Two space-time clusters of gun violence were revealed in the city. Higher rates of segregation, poverty and the summer months were all associated with increased risk of gun violence. Previous gunshots in the area were associated with a 26.8% increase in the risk of gun violence. Gun violence in Syracuse, NY is both spatially and temporally stable, with some neighborhoods of the city greatly afflicted.

Finite element analyses of a linear-accelerator electron gun

Science.gov (United States)

Iqbal, M.; Wasy, A.; Islam, G. U.; Zhou, Z.

2014-02-01

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

Finite element analyses of a linear-accelerator electron gun

Energy Technology Data Exchange (ETDEWEB)

Iqbal, M., E-mail: muniqbal.chep@pu.edu.pk, E-mail: muniqbal@ihep.ac.cn [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Wasy, A. [Department of Mechanical Engineering, Changwon National University, Changwon 641773 (Korea, Republic of); Islam, G. U. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Zhou, Z. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

2014-02-15

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

Finite element analyses of a linear-accelerator electron gun

International Nuclear Information System (INIS)

Iqbal, M.; Wasy, A.; Islam, G. U.; Zhou, Z.

2014-01-01

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator

Thermal and mechanical modelling of a mig-type electron gun

International Nuclear Information System (INIS)

Patire Junior, H.; Castro, J.J.B. de

1995-01-01

A thermal and mechanical modelling of a magnetron injection electron gun has been made to minimize the temperature distribution in the gun elements while keeping the required operating temperature at 1000 0 C of the emitter. Appropriate materials were selected to reduce thermal losses and to improve the gun design from a constructional point of view aiming at extending the capabilities of the gun. A software has been used to simulate a thermal model considering the three processes of thermal transfer and the influence of the physical properties of the materials used. (author). 8 refs., 2 figs, 2 tabs

Luminescence characteristics of Mg2SiO4:Nd

International Nuclear Information System (INIS)

Indira, P.; Subrahmanyam, R.V.; Murthy, K.V.R.

2011-01-01

Thermoluminescence (TL) properties of Magnesium Ortho silicate (2:1) Mg 2 SiO 4 doped with various concentrations of rare earth (Nd) have been studied. The phosphor material were prepared using standard solid state reaction technique and heated specimens at 1100 ± 20 deg C for two hours. 4% Ammonium chloride was used as flux. The received material was grinded in an agate mortar and pestle. The TL exhibited by the Mg 2 SiO 4 with varying concentration of Nd is interesting in nature. It is interesting to note but as the concentration of Nd increases the peak around 125 deg C TL peak intensity increases. But the hump around 200 deg C resolved as TL peak at 253 deg C with high intensity. (author)