Sample records for mg kg-1 sd

  1. Rapacuronium 2.0 or 2.5 mg kg(-1) for rapid-sequence induction : comparison with succinylcholine 1.0 mg kg(-1)

    Blobner, M; Mirakhur, RK; Wierda, JMKH; Wright, PMC; Olkkola, KT; Debaene, B; Pendeville, P; Engbaek, J; Rietbergen, H; Sparr, HJ


    The purpose of this nine-centre study in 602 patients was to show that the frequency of acceptable intubating conditions after rapacuronium 2.0 or 2.5 mg kg(-1) is not more than 10% lower than the frequency after succinylcholine 1.0 mg kg(-1) during rapid-sequence induction of anaesthesia with fenta

  2. Sugammadex 4.0 mg kg-1 reversal of deep rocuronium-induced neuromuscular blockade

    Yu, Buwei; Wang, Xiangrui; Hansen, Søren Helbo


    Objective: Maintenance of deep Neuro Muscular Blockade (NMB) until the end of surgery may be beneficial in some surgical procedures. The selective relaxant binding agent sugammadex rapidly reverses deep levels of rocuronium-induced NMB. The purpose of this study was to evaluate the efficacy...... and safety of sugammadex 4.0 mg kg-1 for reversal of deep rocuronium-induced NMB in Chinese and Caucasian patients. Methods: This was an open-label, multicenter, prospective Phase III efficacy study in adult American Society of Anesthesiologists Class 1-3 patients scheduled for surgery under general...... anesthesia and requiring deep NMB. All patients received intravenous propofol and opioids for induction and maintenance of anesthesia, and a single intubation dose of rocuronium 0.6 mg/kg, with maintenance doses of 0.1-0.2 mg/kg as required. Sugammadex 4.0 mg/kg was administered after the last dose...

  3. Postoperative impairment of motor function at train-of-four ratio ≥0.9 cannot be improved by sugammadex (1 mg kg-1).

    Baumüller, E; Schaller, S J; Chiquito Lama, Y; Frick, C G; Bauhofer, T; Eikermann, M; Fink, H; Blobner, M


    A train-of-four ratio (TOFR) ≥0.9 measured by quantitative neuromuscular monitoring is accepted as an indication of sufficient neuromuscular recovery for extubation, even though many postsynaptic acetylcholine receptors may still be inhibited. We investigated whether antagonism with sugammadex after spontaneous recovery to TOFR≥0.9 further improves muscle function or subjective well-being. Following recovery to TOFR≥0.9 and emergence from anaesthesia, 300 patients randomly received either sugammadex 1.0 mg kg(-1) or placebo. Fine motor function (Purdue Pegboard Test) and maximal voluntary grip strength were measured before and after surgery (before and after test drug administration). At discharge from the postanaesthesia care unit, well-being was assessed with numerical analogue scales and the Quality-of-Recovery Score 40 (QoR-40). Patients' fine motor function [6 (sd 4) vs 15 (3) pegs (30 s)(-1), Psugammadex or placebo, motor function was significantly improved in both groups but did not reach the preoperative level. There was no difference between groups at any time. Global well-being was unaffected (QoR-40: placebo, 174 vs 185; sugammadex, 175 vs 186, P>0.05). Antagonizing rocuronium at TOF≥0.9 with sugammadex 1.0 mg kg(-) (1) did not improve patients' motor function or well-being when compared with placebo. Our data support the view that TOFR≥0.9 measured by electromyography signifies sufficient recovery of neuromuscular function. The trial is registered at (NCT01101139). © The Author 2014. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:

  4. Efficacy, safety and pharmacokinetics of sugammadex 4 mg kg-1 for reversal of deep neuromuscular blockade in patients with severe renal impairment.

    Panhuizen, I F; Gold, S J A; Buerkle, C; Snoeck, M M J; Harper, N J N; Kaspers, M J G H; van den Heuvel, M W; Hollmann, M W


    This study evaluated efficacy and safety of sugammadex 4 mg kg(-1) for deep neuromuscular blockade (NMB) reversal in patients with severe renal impairment (creatinine clearance [CLCR] Sugammadex 4 mg kg(-1) was administered at 1-2 post-tetanic counts for reversal of rocuronium NMB. Primary efficacy variable was time from sugammadex to recovery to train-of-four (T4/T1) ratio 0.9. Equivalence between groups was demonstrated if two-sided 95% CI for difference in recovery times was within -1 to +1 min interval. Pharmacokinetics of rocuronium and overall safety were assessed. The intent-to-treat group comprised 67 patients (renal n=35; control n=32). Median (95% CI) time from sugammadex to recovery to T4/T1 ratio 0.9 was 3.1 (2.4-4.6) and 1.9 (1.6-2.8) min for renal patients vs controls. Estimated median (95% CI) difference between groups was 1.3 (0.6-2.4) min; thus equivalence bounds were not met. One control patient experienced acceleromyography-determined NMB recurrence, possibly as a result of premature sugammadex (4 mg kg(-1)) administration, with no clinical evidence of NMB recurrence observed. Rocuronium, encapsulated by Sugammadex, was detectable in plasma at day 7 in 6 patients. Bioanalytical data for sugammadex were collected but could not be used for pharmacokinetics. Sugammadex 4 mg kg(-1) provided rapid reversal of deep rocuronium-induced NMB in renal and control patients. However, considering the prolonged sugammadex-rocuronium complex exposure in patients with severe renal impairment, current safety experience is insufficient to support recommended use of sugammadex in this population. NCT00702715. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:

  5. Children and parental anxiolysis in paediatric ambulatory surgery: a randomized controlled study comparing 0.3 mg kg-1 midazolam to tablet computer based interactive distraction.

    Marechal, C; Berthiller, J; Tosetti, S; Cogniat, B; Desombres, H; Bouvet, L; Kassai, B; Chassard, D; de Queiroz Siqueira, M


    The operating theatre, anaesthesia induction and separation from parents create fear and anxiety in children. Anxiety leads to adverse behavioral changes appearing and sometimes persisting during the postoperative period. Our aim was to compare the effects of midazolam (0.3 mg kg(-)(1): MDZ) for premedication with age-appropriate tablet game apps (TAB) on children anxiety during and after ambulatory surgery. A randomized controlled trial was conducted from May 16th, 2013 to March 25th, 2014 at the Children Hospital of Lyon. The primary outcome of this study was the change in m-YPAS score at the time of anaesthetic mask induction. Anxiety was also assessed in the waiting surgical area, at the time of separation with parents and when back in the ambulatory surgery ward. One hundred and eighteen patients aged four-11 yr were recruited, 60 in the TAB Group and 58 in the MDZ Group. Main endpoint was missing for three patients from the MDZ Group. At the time of mask induction, there was no significant difference between MDZ and TAB Group for the m-YPAS score (40.5 (18.6) vs 41.8 (20.7), P = 0.99). There was no significant correlation between m-YPAS score and its evolution over the four period of time between subjects. We were not able to show whether TAB is superior to MDZ to blunt anxiety in children undergoing ambulatory surgery. TAB is a non-pharmacological tool which has the capacity in reducing perioperative stress without any sedative effect in this population. NCT 02192710. © The Author 2017. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:


    Suzuki, Toshio [Department of Physics and Graduate School of Integrated Basic Sciences, College of Humanities and Sciences, Nihon University Sakurajosui 3-25-40, Setagaya-ku, Tokyo 156-8550 (Japan); Toki, Hiroshi [Research Center for Nuclear Physics (RCNP), Osaka University, Ibaraki, Osaka 567-0047 (Japan); Nomoto, Ken’ichi, E-mail: [Kavli Institute for the Physics and Mathematics of the Universe (WPI), The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan)


    Electron-capture and β-decay rates for nuclear pairs in the sd-shell are evaluated at high densities and high temperatures relevant to the final evolution of electron-degenerate O–Ne–Mg cores of stars with initial masses of 8–10 M{sub ⊙}. Electron capture induces a rapid contraction of the electron-degenerate O–Ne–Mg core. The outcome of rapid contraction depends on the evolutionary changes in the central density and temperature, which are determined by the competing processes of contraction, cooling, and heating. The fate of the stars is determined by these competitions, whether they end up with electron-capture supernovae or Fe core-collapse supernovae. Since the competing processes are induced by electron capture and β-decay, the accurate weak rates are crucially important. The rates are obtained for pairs with A = 20, 23, 24, 25, and 27 by shell-model calculations in the sd-shell with the USDB Hamiltonian. Effects of Coulomb corrections on the rates are evaluated. The rates for pairs with A = 23 and 25 are important for nuclear Urca processes that determine the cooling rate of the O–Ne–Mg core, while those for pairs with A = 20 and 24 are important for the core contraction and heat generation rates in the core. We provide these nuclear rates at stellar environments in tables with fine enough meshes at various densities and temperatures for studies of astrophysical processes sensitive to the rates. In particular, the accurate rate tables are crucially important for the final fates of not only O–Ne–Mg cores but also a wider range of stars, such as C–O cores of lower-mass stars.

  7. Electron capture and beta-decay rates for sd-shell nuclei in stellar environments relevant to high density O-Ne-Mg cores

    Suzuki, Toshio; Nomoto, Ken'ichi


    Electron capture and beta-decay rates for nuclear pairs in sd-shell are evaluated at high densities and high temperatures relevant to the final evolution of electron-degenerate O-Ne-Mg cores of stars with the initial masses of 8-10 solar mass. Electron capture induces a rapid contraction of the electron-degenerate O-Ne-Mg core. The outcome of rapid contraction depends on the evolutionary changes in the central density and temperature, which are determined by the competing processes of contraction, cooling, and heating. The fate of the stars are determined by these competitions, whether they end up with electron-capture supernovae or Fe core-collapse supernovae. Since the competing processes are induced by electron capture and beta-decay, the accurate weak rates are crucially important. The rates are obtained for pairs with A=20, 23, 24, 25 and 27 by shell-model calculations in sd-shell with the USDB Hamiltonian. Effects of Coulomb corrections on the rates are evaluated. The rates for pairs with A=23 and 25 ar...

  8. Single doses of ivermectin 400 micrograms/kg-1: the most effective dosage in bancroftian filariasis.

    Moulia-Pelat, J P; Glaziou, P; Nguyen, L N; Cartel, J L


    Forty-three Wuchereria bancrofti carriers were given four successive semi-annual single doses of ivermectin 100 (IVER 100). The geometric mean microfilaremia (mf) recurrence percentage as compared to the pre-initial treatment mf level was 35%, 21%, 17% and 17% at 6, 12, 18 and 24 months, respectively. However, the recurrence of mf 6 months after the fourth treatment remained high in several individuals: 15 have been considered as 'bad responders' and 28 as 'good responders' individuals. At month 24 (M 24), they were randomly allocated into 2 groups. A first group was treated with a fifty and a sixth dose of IVER 100, at M24 and M30, respectively; the second one was treated, at the same time, with single doses of IVER 400 (IVER 400). At M 36, the mf recurrence percentage (mf M36/mf M0) was significantly higher in patients treated with IVER 100 than IVER 400 (11% vs 1%, p < 10(-4). From the group IVER 100, 6 out of the 8 'bad responders' remained 'bad responders' whereas there were none of the 7 in the group IVER 400. Moreover, there were only 2 more patients in the group IVER 100 showing sustained complete zero mf, whereas they were 13 in the group IVER 400. Single doses of IVER 400 were effective on 'bad responders'; IVER 400 must be recommended for semi-annual mass treatment in bancroftian filariasis.

  9. Effects of the combination of decitabine and homoharringtonine in SKM-1 and Kg-1a cells.

    Geng, Suxia; Yao, Han; Weng, Jianyu; Tong, Jiaqi; Huang, Xin; Wu, Ping; Deng, Chengxin; Li, Minming; Lu, Zesheng; Du, Xin


    The methylation inhibitor decitabine (DAC) has great therapeutic value for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, DAC monotherapy is associated with relatively low rates of overall response and complete remission. Previous studies have shown promising results for combination treatment regimens including DAC. Homoharringtonine (HHT), an alkaloid from Chinese natural plants and Cephalotaxus, has demonstrated potential for leukemia treatment. Our studies have suggested that the combination of DAC and HHT has synergistic effects for inhibiting the viability of SKM-1 and Kg-1a cells. This combination leads to enhanced inhibition of colony formation and apoptosis induction compared with DAC alone in SKM-1 but not Kg-1a cells. Only high-dose DAC and HHT significantly up-regulate caspase-3 and caspase-9 and inhibit BCL-XL in the SKM-1 cell line. The combined effects of DAC plus HHT on apoptosis may not only depend on regulation of the apoptosis-related genes we examined but others as well. HHT had no demethylation effects, and HHT in combination with DAC had no enhanced effects on hypomethylation and DNMT1, DNMT3A and DNMT3B mRNA expression in SKM-1 cells. Overall, these results suggest that DAC used in combination with HHT may have clinical potential for MDS treatment.

  10. 白藜芦醇增强TRAIL对人髓系白血病KG-1a细胞的细胞毒作用%Resveratrol enhances cytotoxicity of TRAIL to human promyloblastic leukemia KG-1a cells

    胡亮杉; 孙茂本; 曾雅丽; 李玉华; 邓兰; 郭坤元


    目的:观察白藜芦醇作用前后TRAIL对人髓系白血病KG-1a细胞的细胞毒作用的变化.方法:流式细胞仪检测KG-1a细胞表面CD34 和CD38的表达,二甲氧唑黄(XTT)细胞增殖及细胞毒性检测试剂盒检测白藜芦醇作用前后TRAIL对KG-1a细胞增殖的影响,AnnexinV-FITC/PI染色流式细胞仪检测细胞凋亡变化.流式细胞仪检测白藜芦醇作用前后KG-1a细胞表面TRAIL死亡受体表达变化.结果:人髓系白血病KG-1a细胞 CD34+CD38-占(58.67±2.87)%,10~1 000 ng/ml 的TRAIL对KG-1a细胞增殖无明显影响,但对白藜芦醇作用后的KG-1a细胞的增殖有明显抑制作用,白藜芦醇能促进TRAIL诱导KG-1a细胞凋亡,并能上调KG-1a细胞表面TRAIL死亡受体DR5的表达.结论:白藜芦醇能增强TRAIL对人髓系白血病KG-1a细胞的细胞毒作用,其机制可能与白藜芦醇上调KG-1a细胞表面TRAIL死亡受体DR5的表达有关.%Objective :To explore the cytotoxicity of TRAIL to human acute promyeloblastic leukemia KG-1a cells treated with resvera trol .Methods :The expression of CD34 and CD38 on the Surface of KG-1 cells was detected by flow cytometry ;The effects of various concentration TRAIL on proliferation of KG-1a cells treated with or without resveratrol were analyzed by XTT cell proliferation and cytotoxicity assay kit ;The changes of apoptosis in KG-1a cells treated with or without resveratrol induced by TRAIL were detected by flow cytometry through the staining of AnnexinV-FITC /PI ;The effects of resveratrol on the expression of DR4/5 on the surface of KG-1a cells were detected by flow cytometry .Results :The CD34+ CD38- percent age of KG-1a cells was (58 .67±2 .87 )% ;10-1 000 ng/ml of TRAIL had no effects on the proliferation of KG-1a cells ,while could inhibit the proliferation of KG-1a cells treated with resveratrol ;Moreover ,resveratrol could enhance the apoptosis of KG-1a cells induced by TRAIL and up-regulate the expression of TIRAIL death receptors DR5

  11. Research on the Treatment of SD Rats Vascular Balloon Injury with Salvia and Panax Notoginseng Different Ethanol Extracts%三七与丹参不同洗脱部位对大鼠血管球囊损伤再狭窄的治疗作用研究

    王云飞; 潘从泽; 高秀梅; 王升启


    Objective: To investigate the treatment of SD rats vascular balloon injury with Salvia and Panax Notoginseng different ethanol extracts. Methods:84 SD rats were randomly divided into 14 groups:normal group,model group,sham operation group, Alpha statin calcium group(3 mg·kg-1·d-1) ,Fufang Danshen tablet group(300 mg·kg-1·d-1 ) ,50% Elution position high intermediate low dose group(300 mg·kg-1·d-1,150mg·kg-1·d-1 ,75 mg·kg-1·d-1) ,80% Elution position high intermediate low dose group(300mg·kg-1·d-1,150mg·kg-1·d-1,75 mg·kg-1·d-1 ) ,95% Elution position high intermediate low dose group(300 mg·kg-1·d-1,150 mg·kg-1·d-1,75 mg·kg-1·d-1 ) ,with intragastric administration. The balloon catheter injury method was used to establish model of intimal hyperplasia of rats carotid artery. After seven days,the serum SOD, NO and MDA levels were measured. The endometrium ( NIA) and the membrane ( MA) area ratio were calculated. Immunohisto-chemical detection of vascular injury in PCNA,VEGF and NF - κb expressions were observed. Results:50% Elution position intermediate dose group and 95% Elution position high dose group SOD compared with model group have significant difference. Conclusion:Salvia and Panax Notoginseng 50% as well as 95% elution position( 150 mg·kg-1·d-1)can inhibit the SD rat carotid artery balloon injury hyperplasia.%目的:探讨三七与丹参不同提取部位对SD大鼠左侧颈总动脉球囊损伤再狭窄的治疗作用.方法:SD大鼠,雄性,82只,分为正常组、模型组、假手术组、阿伐脱他汀钙片组(3 mg· kg-1·d-1)、复方丹参片组(300mg·kg-1·d-1)、50%洗脱部位高中低剂量组(300、150、75 mg·kg-1·d-1)、80%洗脱部位高中低剂量组(300、150、75 mg·kg-1·d-1)、95%洗脱部位高中低洗脱部位(300、150、75 mg·kg-1·d-1)灌胃.用球囊导管损伤建立大鼠颈总动脉内膜增生模型,7天后,测其血清中SOD、NO、MDA水平,计算其内膜(NIA

  12. TGF-β1对白血病KG-1细胞株Gli1表达的影响%Effect of TGF-β1 on Gli1 expression in KG-1 cell line

    李哲; 潘静


    Objective To prove that there was cross talk between Hh signaling pathway and TGF-β signaling pathway in KG-1 cells line. Methods (1) KG-1 cells were treated with 0. 1 ng/mL,l ng/mL,and 10 ng/mL TGF-β1 for 6 h,12 h,and 24 h respectively. Cells were collected after stimulation. Total mRNA was extracted. Glil expression was detected by real-time PCR. (2) KG-1 cells were treated with 5 ng/mL TGFβ1 and 5 ng/mL TGF-β1 +5 μmol SIS3 respectively for 24h. Cells were collected after stimulation. Total mRNA was extracted. Glil expression was detected. Results (1) When 1- 10 ng/mL TGF-β1 acted on the KG-1 cells respectively for 6 h, 12 h and 24 h, significant reduction of Glil mRNA in response to TGF-β1 was observed in KG-1 cells, emerging at 12 h and lasting at least 24 h,lower than that of the control group. (2) When 5 ng/mL TGF-β1 and 5 ng/mL TGF-β1 +5 μmol SIS3 acted on the KG-1 cells respectively for 24 h respectively,Glil expression of mRNA of control group was higher than that of TGF-β1 group, while much lower than that of TGF-β1 +SIS3 group. Conclusion TGF-β1significantly decreased Glil expression in KG-1 cells. Glil induction in KG-1 cells by TGF-β1 was a Smad3-dependent manner. This effect was independent from the Ptch/Smo axis.%目的 证明在白血病KG-1细胞株中存在TGF-β信号通路对Gli的调控作用.方法 (1)用0.1、1、10 ng/mL TGF-β1分别作用于KG-1细胞,时间分别为6、12、24 h.处理结束后收集细胞,提取mRNA,检测Gli1的表达.(2)5 ng/mL TGF-β1、5 ng/mL TGF-β1联合5 μmol SIS3分别作用于KG-1细胞24 h.处理结束后收集细胞,提取mRNA,检测Gli1的表达.结果 (1)1~10 ng/mL TGF-β1分别作用于KG-1细胞6、12、24 h,从12 h起并至少持续至24 h,其Gli1的mRNA表达较对照组明显减少;(2)5 ng/mL TGF-β1、5ng/mL TGF-β1联合5 μmol SIS3分别作用于KG-1细胞24 h,其Gli1的mRNA表达与对照组比较:5 ng/mL TGF-β1组较对照组降低,而5 ng/mL TGF-β1联合5 μmol SIS3组较

  13. Magnetic gold nanoparticles: synthesis, characterization and its application in the delivery of FITC into KG-1 cells.

    Hao, Yuzhi; Song, Steven; Yang, Xiaoyan; Xing, James; Chen, Jie


    In this article, we report a new method-a sonication method to disperse iron oxide nanoparticles into smaller nanoparticles and make gold ions absorb onto the surface or trapped in the micropores of the iron oxide nanoparticles using sonication action. By using quick reduction of ascorbic acid and post-HCI solution treatment, gold covered magnetic nanoparticles (mGNPs) with spherical morphology and uniform size were synthesized in a water solution. The size of the mGNPs was found to be 20-30 nm. Some ideal mGNPs possessed a core-shell structure. The mGNPs were non-cytotoxic and mGNP-fluorescein isothiocyanate (FITC) can enter KG-1 cells when driven by an external magnetic force, which was confirmed by confocal imaging. The confocal image also showed the FITC inside the KG-1 cells was near the nucleus. The fluorescein isothiocyanate (FITC) delivery efficiency is about 100% according to the flow cytometry results.

  14. Effect of vanillin inhalation on serum magnesium levels in depressed SD rat model%Vanillin吸嗅对抑郁模型SD大鼠血清Mg2+的影响

    许慧; 刘扬; 王艳梅; 徐金勇; 李光武


    目的 探讨嗅质香兰素(Vanillin)吸嗅对SD大鼠抑郁样行为的调节作用及可能的作用机制.方法 雄性SD大鼠70只,采用CUMS+孤养或嗅球毁损,制备抑郁样模型,符合模型大鼠随机分为Vanillin吸嗅组、氟西汀组、模型组、嗅球毁损+ Vanillin吸嗅组及假手术组.评价大鼠干预后各时间点的神经行为学变化及血清Mg2+含量.结果 (Vanillin吸嗅组干预2w后强迫游泳实验时间明显缩短(P <0.05);24h糖水消耗量实验明显增加(P<0.05);5w后旷野实验自主活动次数增加(P<0.05);血清Mg2含量明显提高(P<0.05).结论 Vanillin吸嗅可以缓解抑郁模型大鼠的抑郁样行为,其机制可能是提高血清Mg2含量,通过Mg2调控HPA轴,影响海马、杏仁核情绪中枢活动,从而达到防治抑郁症的作用.

  15. Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells

    Fuchs, Dominik [Research Group Molecular Neuro-Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg (Germany); Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg (Germany); Daniel, Volker; Sadeghi, Mahmoud; Opelz, Gerhard [Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg (Germany); Naujokat, Cord, E-mail: [Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg (Germany)


    Leukemia stem cells are known to exhibit multidrug resistance by expression of ATP-binding cassette (ABC) transporters which constitute transmembrane proteins capable of exporting a wide variety of chemotherapeutic drugs from the cytosol. We show here that human promyeloblastic leukemia KG-1a cells exposed to the histone deacetylase inhibitor phenylbutyrate resemble many characteristics of leukemia stem cells, including expression of functional ABC transporters such as P-glycoprotein, BCRP and MRP8. Consequently, KG-1a cells display resistance to the induction of apoptosis by various chemotherapeutic drugs. Resistance to apoptosis induction by chemotherapeutic drugs can be reversed by cyclosporine A, which effectively inhibits the activity of P-glycoprotein and BCRP, thus demonstrating ABC transporter-mediated drug resistance in KG-1a cells. However, KG-1a are highly sensitive to apoptosis induction by salinomycin, a polyether ionophore antibiotic that has recently been shown to kill human breast cancer stem cell-like cells and to induce apoptosis in human cancer cells displaying multiple mechanisms of drug and apoptosis resistance. Whereas KG-1a cells can be adapted to proliferate in the presence of apoptosis-inducing concentrations of bortezomib and doxorubicin, salinomycin does not permit long-term adaptation of the cells to apoptosis-inducing concentrations. Thus, salinomycin should be regarded as a novel and effective agent for the elimination of leukemia stem cells and other tumor cells exhibiting ABC transporter-mediated multidrug resistance.

  16. Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.


    Alcohol Denat. is the generic term used by the cosmetics industry to describe denatured alcohol. Alcohol Denat. and various specially denatured (SD) alcohols are used as cosmetic ingredients in a wide variety of products. Many denaturants have been previously considered, on an individual basis, as cosmetic ingredients by the Cosmetic Ingredient Review (CIR) Expert Panel, whereas others, including Brucine and Brucine Sulfate, Denatonium Benzoate, and Quassin, have not previously been evaluated. Quassin is a bitter alkaloid obtained from the wood of Quassia amara. Quassin has been used as an insect antifeedant and insecticide and several studies demonstrate its effectiveness. At oral doses up to 1000 mg/kg using rats, Quassin was not toxic in acute and short-term tests, but some reversible piloerection, decrease in motor activity, and a partial loss of righting reflex were found in mice at 500 mg/kg. At 1000 mg/kg given intraperitoneally (i.p.), all mice died within 24 h of receiving treatment. In a cytotoxicity test with brine shrimp, 1 mg/ml of Quassin did not possess any cytotoxic or antiplasmodial activity. Quassin administered to rat Leydig cells in vitro at concentrations of 5-25 ng/ml inhibited both the basal and luteinizing hormone (LH)-stimulated testosterone secretion in a dose-related fashion. Quassin at doses up to 2.0 g/kg in drinking water using rats produced no significant effect on the body weights, but the mean weights of the testes, seminal vesicles, and epididymides were significantly reduced, and the weights of the anterior pituitary glands were significantly increased. The sperm counts and levels of LH, follicle-stimulating hormone (FSH), and testosterone were significantly lower in groups treated with Quassin. Brucine is a derivative of 2-hydroxystrychnine. Swiss-Webster mice given Brucine base, 30 ml/kg, had an acute oral LD(50) of 150 mg/kg, with central nervous system depression followed by convulsions and seizures in some cases. In those

  17. Long-term efficacy of single-dose treatment with 400 of ivermectin in bancroftian filariasis: results at one year.

    Moulia-Pelat, J P; Glaziou, P; Nguyen, L N; Chanteau, S; Martin, P M; Cartel, J L


    In April 1992, a safety trial was performed with a single dose of ivermectin 400 (IVER 400). In 37 bancroftian filariasis carriers, 6 and 12 months after IVER 400 treatment, the microfilaremia recurrences were 3.2% and 13.5%, respectively. As compared to results from other studies with diethylcarbamazine and IVER at different dosages and periodicities, the dosage of IVER 400 seems the most effective; but a yearly intake might not be sufficient.

  18. 蝎毒多肽对白血病细胞株KG1a干细胞活性的影响%Study on the effects of PESV on the viability of leukemia stem cells line KG1a

    杨向东; 李红玉; 李德冠; 史哲新; 杨文华; 颜田赅; 闫理想; 王兴丽



  19. Resistance of Leukemia KG1 a Cells with Positive N-cadherin in Phase G0Against Killing Activity of VP16%N-cadherin阳性白血病KG1a细胞系在G0期抵抗VP16杀伤的作用

    何侃; 于沛; 邢海燕; 李艳; 田征; 王敏; 唐克晶; 饶青


    抗药性是白血病干细胞的重要特征,为探索N-cadherin阳性的白血病细胞耐受化疗药物VP16杀伤作用的机制,本研究以白血病细胞系KGla为研究模型,利用流式细胞术测定N-cadherin阳性和N-cadherin阴性细胞在G0期比例的差异,利用G-CSF诱导KG1a细胞进入细胞周期,观察G0期细胞比例的变化,并测定诱导后KG1a细胞对VP16的敏感性;再利用EGTA抑制N-cadherin介导的细胞间黏附后,观察KG1a细胞耐药性的变化.结果 显示,N-cadherin阳性的KG1a细胞G0期比例高于N-cadherin阴性的细胞;诱导KG1a细胞进入细胞周期后G0期细胞比例明显下降,KG1a细胞对VP16的敏感性显著升高;利用EGTA处理KG1a细胞24小时抑制N-cadherin的作用后,KG1a细胞在G0期比例降低,KG1a细胞对VP16的药物敏感性显著升高.结论:N-cadherin通过介导白血病细胞之间的黏附作用,使白血病细胞处于G0期的静息状态,从而耐受VP16的杀伤作用.%This study was aimed to investigate the methylation status of WTI gene in leukemia cell lines and its relation with expression of WTI gene. The WTI gene was silenced by DNA methylation or histone deacetylation, and the expression of WTI gene was induced by using HDAC inhibitor and/or demethylation agent of DNA. Some leukemia cell lines (U937, HL-60, K562, KG1) were detected by RT-PCR, MS-PCR, restriction analysis, and DNA sequencing. U937 leukemic cells without WTI mRNA expression were incubated with HDAC inhibitor Trichostatin A (TSA) and/or demethylation agent decitabine. The results showed that the U937 cells did not express WTI gene, but HL-60, K562 and KG1 cells hyghly expressed WTI gene; WTI gene was unmethylated in HL-60 cells, but methylated in K562 and U937 cells. WTI expression could be reactivated by co-incubation with TSA and decitabine, but not was observed by using single drug. It is concluded that WTI promoter is methylated in some leukemia cells, however, the methylation can not affect

  20. Study on the Functional Expression of P2X7 Receptor in Human Leukemic Cell Line KG1a%人白血病细胞系KG1a中P2X7受体的表达和功能研究

    张秀军; 孟丽君



  1. SD card projects using the PIC microcontroller

    Ibrahim, Dogan


    PIC Microcontrollers are a favorite in industry and with hobbyists. These microcontrollers are versatile, simple, and low cost making them perfect for many different applications. The 8-bit PIC is widely used in consumer electronic goods, office automation, and personal projects. Author, Dogan Ibrahim, author of several PIC books has now written a book using the PIC18 family of microcontrollers to create projects with SD cards. This book is ideal for those practicing engineers, advanced students, and PIC enthusiasts that want to incorporate SD Cards into their devices. SD cards are che

  2. The SD oscillator and its attractors

    Cao, Q [Department of Mathematics and Physics, Shijiazhuang Railway Institute, Shijiazhuang 050043 (China); Wiercigroch, M; Pavlovskaia, E; Grebogi, C; Michael, J; Thompson, T [Centre for Applied Dynamics Research, School of Engineering, University of Aberdeen, King' s College, Aberdeen AB24 3UE, Scotland (United Kingdom)], E-mail:


    We propose a new archetypal oscillator for smooth and discontinuous systems (SD oscillator). This oscillator behaves both smooth and discontinuous system depending on the value of the smoothness parameter. New dynamic behaviour is presented for the transitions from the smooth to discontinuous regime.

  3. Establishment and evaluation of adriamycin-induced chronic heart failure model in SD rats%SD大鼠阿霉素慢性心力衰竭模型的建立与评价

    吴运香; 张野; 谢春林; 张书杰; 解翔; 姜凡; 陈志武


    Aim To establish and evaluate an adriamycin-induced chronic heart failure model by tail vein injection in Sprague Dawley ( SD ) rats. Methods Adult male SD rats were randomly divided into two groups : the control group ( CON,n = 8 ) and the adriamycin-induced heart failure group ( ADR,n = 20 ).All rats in ADR group received 2 mg · kg-1adriamycin as an intravenous tail vein infusion once a week for 6 weeks at a total dose of 12 mg · kg-1 ; meanwhile in CON group, rats received an equal volume of 0. 9% sodium chloride intravenously. Transthoracic: echocardiography was performed to observe cardiac function including left ventricular end-diastolic diameter( LVEDD ) and end-systolic diameter ( LVESD ) and calculate left ventricular fractional shortening ( LVFS ) and ejection fraction ( LVEF ) 2 weeks later after the last injection. The pathological c:hange was analyzed by HE and Van Gieson ( VG ) stain. The plasma concentration of brain natriuretic peptide ( BNP ) was determined by euzymelinked immunosorbent assay ( ELISA ). Results Compared with CON group, LVEDD and LVESD were increased in ADR group, and LVFS and LVEF were significantly decreased ( P < 0. 01 ). The pathological changes by HE stain in ADR group were part of myocardial fiber fracture and myocardial periacardial inflammatory infiltration. Collagen volume fraction ( CVF ) and perivascular circumferential collagen area ( PVCA )by VG stain were significantly higher( P < 0. 01 ) than CON group. And the level of plasma BNP was significantly higher than that in CON group. Conclusions Adriamycin at a multiple intravenous dose of 2. 0 mg · kg-1 can be used to establish a reliable model of non-ischemia chronic heart failure in SD rats and lead to a decline in ventricular function and pathological changes.%目的 通过尾静脉注射阿霉素建立SD大鼠慢性心力衰竭模型,并对其进行评价.方法 成年♂SD大鼠随机分为两组:正常对照组(CON组,n=8)和

  4. Chromosome location of semidwarf gene sd t and sd n in indica rice


    Great achievements have been made in breeding of semidwarf varieties (indica) since 1960s. Results showed that the dwarf traits widely used at present were controlled by the same recessive major gene, sd 1, thus we faced the potential danger of losing genetic diversity. The low yield of semidwarf varieties newly bred in domestic or abroad may be related to the narrow use of dwarf resource. So it was important to explore, appraise, and use new semidwarf resource. In the last decade, we have found two non allelic semidwarf genes, sd t and sd n. To utilize the new semidwarf genes in breeding efficiently, genetic analysis was necessary.

  5. Gambaran Obesitas pada Siswa Sekolah Dasar di SD Pertiwi dan SD Negeri 03 Alai Padang

    Rizqa Fiorendita Hadi


    Full Text Available AbstrakObesitas merupakan permasalahan serius yang mulai menjadi perhatian di seluruh dunia. Pada beberapa dekade terakhir prevalensi obesitas pada anak mulai mengalami peningkatan. Tujuan dari penelitian ini adalah untuk melihat gambaran obesitas yang terjadi pada siswa sekolah dasar di SD Pertiwi dan SD Negeri 03 Alai Padang serta hubungan usia dan jenis kelamin dengan obesitas pada siswa di SD Pertiwi dan SD Negeri 03 Alai Padang. Penelitian ini bersifat deskriptif dengan desain cross sectional yang dilaksanakan pada bulan Agustus – September 2013. Populasi dari penelitian ini adalah semua murid kelas I sampai VI SD Pertiwi dan SD Negeri 03 Alai Padang. Sampel untuk pemeriksaan berat badan, tinggi badan, dan IMT yang memenuhi kriteria inklusi dan ekslusi berjumlah 93 anak. Data diperoleh dengan melakukan pemeriksaan tinggi badan, berat badan, dan IMT dengan menggunakan kurva BMI-CDC 2000. Siswa yang terpilih secara acak di SD Pertiwi dan SD Negeri 03 Alai dilakukan pengukuran berat badan, tinggi badan, dan IMT, didapatkan frekuensi obesitas pada anak adalah sebesar 10,8%. Frekuensi obesitas lebih tinggi pada siswa laki-laki (13%. Kejadian obesitas banyak ditemukan pada anak berusia >9 tahun yaitu 14,7%. Berdasarkan hasil uji statistik yang dilakukan dengan metode chi square, tidak terdapat hubungan yang bermakna antara usia dan jenis kelamin dengan obesitas pada siswa sekolah dasar (p>0,05.Kata kunci: obesitas, usia, jenis kelaminAbstractObesity is a serious problem that is starting to become a worldwide concern. In recent decades the prevalence of obesity in children began to increase around the world. The purpose of this study is to see an overview of obesity that occurs in primary school students in SD Pertiwi and SD Negeri 03 Alai Padang and the relationship of age and gender to obesity in SD Pertiwi and SD Negeri 03 Alai Padang. This study is a descriptive cross- sectional design and the study was conducted in August-September 2013

  6. Decursin Mediated Protection on Cisplatin-induced Nephrotoxicity in SD Rats and BDF1 Mice

    Jiang Cheng-zhe; Han Ilhyun; Choung Seyoung


    Tisplatin is one of the valuable icancer agents against several types of neoplasm. However, nephrotoxicity is the major adverse effect representing in cisplatin therapy. In this study, the animal tests detecting protective effects of a natural compound, Decursin, on cisplatin-induced nephrotoxicity were examined by using in vivo model. Pretreatment Decursin 10, 20 and 40 mg · kg^-1 at 48, 24 and 6 h, and administration of a single dose of Cisplatin 5.2 mg · kg^-1. Nephrotoxicity was evaluated by serum BUN and creatinine examination. There was significant difference in body weights, serum BUN and creatinine levels of the normal group. Based on the new understanding of the protective mechanisms of cisplatin-induced nephrotocivity, new strategies can be developed to prevent renal injury or to enhance recovery after cisplatin treatment.

  7. Proper conformal symmetries in SD Einstein spaces

    Chudecki, Adam


    Proper conformal symmetries in self-dual (SD) Einstein spaces are considered. It is shown, that such symmetries are admitted only by the Einstein spaces of the type [N]x[N]. Spaces of the type [N]x[-] are considered in details. Existence of the proper conformal Killing vector implies existence of the isometric, covariantly constant and null Killing vector. It is shown, that there are two classes of [N]x[-]-metrics admitting proper conformal symmetry. They can be distinguished by analysis of the associated anti-self-dual (ASD) null strings. Both classes are analyzed in details. The problem is reduced to single linear PDE. Some general and special solutions of this PDE are presented.

  8. NLTE analyses of sdB stars: progress and prospects

    Przybilla, N; Edelmann, H


    We report on preliminary results of a hybrid non-LTE analysis of high-resolution, high-S/N spectra of the helium-rich subdwarf B star Feige49 and the helium-poor sdB HD205805. Non-LTE effects are found to have a notable impact on the stellar parameter and abundance determination. In particular the HeI lines show significant deviations from detailed balance, with the computed equivalent widths strengthened by up to ~35%. Non-LTE abundance corrections for the metals (C, N, O, Mg, S) are of the order ~0.05-0.25 dex on the mean, while corrections of up to ~0.7 dex are derived for individual transitions. The non-LTE approach reduces systematic trends and the statistical uncertainties in the abundance determination. Consequently, non-LTE analyses of a larger sample of objects have the potential to put much tighter constraints on the formation history of the different sdB populations than currently discussed.

  9. Deformed $sd$-shell nuclei from first principles

    Jansen, G R; Hagen, G; Navrátil, P


    We extend the ab initio coupled-cluster effective interaction (CCEI) method to deformed open-shell nuclei with protons and neutrons in the valence space, and compute binding energies and excited states of isotopes of neon and magnesium. We employ a nucleon-nucleon and three-nucleon interaction from chiral effective field theory evolved to a lower cutoff via a similarity renormalization group transformation. We find good agreement with experiment for binding energies and spectra, while charge radii of neon isotopes are underestimated. For the deformed nuclei $^{20}$Ne and $^{24}$Mg we reproduce rotational bands and electric quadrupole transitions within uncertainties estimated from an effective field theory for deformed nuclei, thereby demonstrating that collective phenomena in $sd$-shell nuclei emerge from complex ab initio calculations.


    Widya Setyaningrum Bagyoastuti


    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan: (1 peran kepala sekolah dalam memberdayakan perpustakaan sekolah dasar, dan (2 peran pustakawan dalam memberdayakan perpustakaan sekolah dasar. Pendekatan kualitatif digunakan dalam penelitian ini dengan menjadikan perpustakaan SD Muhammadiyah Sapen dan SD Negeri Giwangan sebagai subjek penelitian. Data penelitian dikumpulkan melalui teknik observasi, wawancara, dan dokumentasi kemudian dianalisis dengan mengacu pada model interaktif menurut Miles dan Huberman. Hasil penelitian menunjukkan bahwa pemberdayaan perpustakaan sekolah dasar dimulai manakala terdapat dukungan kepala sekolah dan hadirnya pustakawan penuh waktu yang profesional. Kepala sekolah berperan sebagai (1 manajer sekolah, (2 pemimpin instruksional, dan (3 agen perubahan. Pustakawan berperan sebagai (1 manajer perpustakaan, (2 ahli informasi dan penggiat literasi informasi, (3 pelaku instruksional, dan (4 kolaborator. Pemberdayaan perpustakaan dapat dilakukan dengan (1 meningkatkan partisipasi warga sekolah dalam pengembangan koleksi pustaka, (2 meningkatkan kolaborasi antara pustakawan dengan guru dalam pembelajaran, dan (3 pengembangan literasi informasi yang terintegrasi ke dalam pembelajaran.


    Erlisnawati Erlisnawati


    Full Text Available Masalah Motivasi Siswa SD pada ilmu pengetahuan Sosial. Motivasi adalah hal yang sangat penting yang mempengaruhi kegiatan / pekerjaan yang dilakukan oleh individu, termasuk yang mempengaruhi siswa dalam kegiatan belajar. Motivasi adalah salah satu elemen yang paling penting dalam pengajaran yang efektif. Pembelajaran diikuti oleh siswa yang termotivasi untuk menjadi benar-benar menyenangkan, terutama untuk guru. Siswa termotivasi untuk belajar sesuatu akan menggunakan proses kognitif yang lebih tinggi belajar dan menyerap dan mengingat lebih dari itu. Motivasi sebagai proses internal yang memungkinkan, membimbing dan mempertahankan perilaku dari waktu ke waktu. Ada beberapa teori motivasi yaitu: teori perilaku, teori kebutuhan, teori atribusi, teori belajar mandiri dan teori harapan. Motivasi dipengaruhi oleh faktor intrinsik dan faktor ekstinsik. Guru harus mengetahui kondisi ketika siswa termotivasi dan ketika kondisi siswa tidak termotivasi. Untuk itu seorang guru harus memiliki kemampuan untuk memotivasi siswa. Adapun cara yang bisa dilakukan untuk memotivasi guru untuk meningkatkan siswa adalah untuk membangkitkan minat, menjaga rasa ingin tahu, menggunakan berbagai cara yang menarik menyajikan, membantu siswa menentukan target mereka sendiri. Pembelajaran yang dilakukan oleh siswa dengan mitivasi tinggi akan menciptakan proses pembelajaran yang efektif.Kata kunci: masalah, motivasi, ilmu pengetahuan sosial, sekolah dasarMotivation is a very important thing that affects the activities / work performed by the individual, including that affect students in learning activities. Motivation is one of the most important elements in effective teaching. Learning followed by students who are motivated to be really fun, especially for teachers. Students are motivated to learn something will use higher cognitive processes learn and absorb and remember more of it. Motivation as internal processes that enable, guide and sustain behavior over time. There

  12. Resonances in s-d shell nuclei

    Schiffer, J.P.


    It appears that the system we have studied here, /sup 24/Mg(/sup 16/O,/sup 12/C)/sup 28/Si representing /sup 40/Ca as the composite nucleus, is perhaps the heaviest one that exhibits strong enough resonances that quantitative measurements may be contemplated. But we have uncovered only a small corner of what is there and even within this system a huge amount of work remains. The nature of these resonances is not yet clear. The sequence may perhaps have an explanation that is schematically outlined, namely that there are several families of quasistationary states in /sup 40/Ca, but that the slopes of these families do not necessarily coincide with the slope of the grazing partial waves that provide us with a narrow transparent strip of a window on the underlying structure of the nucleus. We must concentrate a lot of effort and ingenuity in order to maximize the information we gather through this window and only then may we hope to sensibly attempt forming hypotheses about the underlying simple pattern.

  13. Atmospheric parameters and abundances of sdB stars

    Heber, U


    We summarize recent results of quantitative spectral analyses using NLTE and metal line-blanketed LTE model atmospheres. Temperatures and gravities derived for hundreds of sdB stars are now available and allow us to investigate systematic uncertainties of teff, log g scales and to test the theory of stellar evolution and pulsations. Surface abundance patterns of about two dozen sdB stars are surprisingly homogenous. In particular the iron abundance is almost solar for most sdBs. We highlight one iron deficient and three super metal-rich sdBs, a challenge to diffusion theory. SdB stars are slowly rotating stars unless they are in close binary systems which is hard to understand if the sdB stars were formed in merger events. The only exception is the pulsator PG 1605+072 rotating at v sin i = 39km/s. Signatures of stellar winds from sdB stars have possibly been found.

  14. SD-PAMs: What, Where, When and How?



    This paper examines what ''sustainable development policies and measures'' (SD-PAMs) could be, and how they could be implemented and could fit into a post-2012 climate regime. This paper assumes that the option to implement SD-PAMs instead of quantified GHG emission commitments post-2012 is an option that would be likely to be only open to non-Annex I countries. There are several key, but unanswered, questions related to SD-PAMs. These include policy-related issues such as which countries could take on commitments to implement SD-PAMs (rather than quantified emission commitments)? Why would particular countries decide to take on such commitments? They also include questions related to how SD-PAMs could be implemented. For many other options for possible post-2012 GHG mitigation actions, including by non-Annex I countries, have also been proposed. However, this paper focuses solely on SD-PAMs.

  15. A dynamic performance evaluation method based on SD-BSC

    TENG Chun-xian; PAN Xiao-dong; HU Xian-wu


    Taking into consideration the disadvantage of Balanced Scorecard (BSC) not being able to reflect time delay, nonlinear problems of causal relationship and being lack of effective simulation, we combined it with the characteristics of the System Dynamics (SD). Basing on the background of manufacturing enterprises,through SD integrating with the BSC we established a new performance evaluation method-SD-BSC method to overcome the disadvantage of BSC. A performance evaluation model of SD-BSC is provided and the simulation results are analyzed which show different production policies will lead to different customer's satisfaction degrees. The SD-BSC dynamic performance evaluation method can reflect dynamic, complex causal feedback relationship and time delay, so it compensates for the disadvantage of traditional financial performance evaluation method, and at the same time makes the BSC perfect.

  16. User's Manual for Space Debris Surfaces (SD_SURF)

    Elfer, N. C.


    A unique collection of computer codes, Space Debris Surfaces (SD_SURF), have been developed to assist in the design and analysis of space debris protection systems. SD_SURF calculates and summarizes a vehicle's vulnerability to space debris as a function of impact velocity and obliquity. An SD_SURF analysis will show which velocities and obliquities are the most probable to cause a penetration. This determination can help the analyst select a shield design which is best suited to the predominant penetration mechanism. The analysis also indicates the most suitable parameters for development or verification testing. The SD_SURF programs offer the option of either FORTRAN programs and Microsoft EXCEL spreadsheets and macros. The FORTRAN programs work with BUMPERII version 1.2a or 1.3 (Cosmic released). The EXCEL spreadsheets and macros can be used independently or with selected output from the SD_SURF FORTRAN programs.

  17. SdAb heterodimer formation using leucine zippers

    Goldman, Ellen R.; Anderson, George P.; Brozozog-Lee, P. Audrey; Zabetakis, Dan


    Single domain antibodies (sdAb) are variable domains cloned from camel, llama, or shark heavy chain only antibodies, and are among the smallest known naturally derived antigen binding fragments. SdAb derived from immunized llamas are able to bind antigens with high affinity, and most are capable of refolding after heat or chemical denaturation to bind antigen again. We hypothesized that the ability to produce heterodimeric sdAb would enable reagents with the robust characteristics of component sdAb, but with dramatically improved overall affinity through increased avidity. Previously we had constructed multimeric sdAb by genetically linking sdAb that bind non-overlapping epitopes on the toxin, ricin. In this work we explored a more flexible approach; the construction of multivalent binding reagents using multimerization domains. We expressed anti-ricin sdAb that recognize different epitopes on the toxin as fusions with differently charged leucine zippers. When the initially produced homodimers are mixed the leucine zipper domains will pair to produce heterodimers. We used fluorescence resonance energy transfer to confirm heterodimer formation. Surface plasmon resonance, circular dichroism, enzyme linked immunosorbent assays, and fluid array assays were used to characterize the multimer constructs, and evaluate their utility in toxin detection.

  18. Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats.

    Alam, Janey; Mujahid, Md; Badruddeen; Jahan, Yasmeen; Bagga, Paramdeep; Rahman, Md Azizur


    Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of 'ethanolic extract of Aquilaria agallocha ( Chen Xiang) leaves' (AAE) against paracetamol (PCM) induced hepatotoxicity in SD rats. Group I animals were treated with 1% CMC for 8 days. Group II, III, IV and V animals were first treated with '1% CMC' 1 ml/kg/day, AAE 200 mg/kg/day, AAE 400 mg/kg/day and silymarin 100 mg/kg/day respectively for 7 days and then, orally administered with PCM 3 g/kg b. wt. on 8th day in a single dose. 24 h after the last dosing by PCM, the blood was obtained through the retro-orbital plexus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, cholesterol, TP and ALB. Group IV rats showed significant (p rats. Hepatoprotective potential of AAE 400 mg/kg/day was comparable to that of standard drug silymarin 100 mg/kg/day. Results of the study were well supported by the histopathological observations. This study confirms that AAE possesses hepatoprotective potential comparable to that of standard drug silymarin as it exhibited comparable protective potential against PCM induced hepatotoxicity in SD rats.

  19. SD-OCT findings in polypoidal choroidal vasculopathy.

    Asensio-Sánchez, V M


    To examine patients with polypoidal choroidal vasculopathy (PCV), using spectral-domain optical coherence tomography (SD-OCT) to characterise and locate the PCV lesions. A series of 15 eyes of 10 patients diagnosed with PCV were examined. All eyes were imaged with macular SD-OCT. SD-OCT cross-sectional scan findings included atypical and typical pigment epithelial detachments (PEDs). Polyps and neovascularisation were located above Bruch membrane. All 15 eyes (100%) showed sub-retinal fluid (SRF) in association with PEDs. These SD-OCT findings located the vascular lesions of PCV in the sub-retinal pigment epithelium (RPE) space, and strongly suggest that PCV is a variant of type 1 neovascularization. Copyright © 2015. Published by Elsevier España, S.L.U.

  20. 76 FR 34286 - South Dakota Disaster Number SD-00041


    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION South Dakota Disaster Number SD-00041 AGENCY: U.S. Small Business Administration. ACTION... the following areas as adversely affected by the disaster. Primary Counties: Stanley. All...

  1. Biota - 2011 Vegetation Inventory - Mud Lake, MN/SD

    Army Corps of Engineers, Department of the Army, Department of Defense — 2011 Vegetation Classification for Mud Lake, MN/SD Vegetation Project Report, OMBIL Environmental Stewardship - Level 1 Inventory. Mud Lake, located on the Minnesota...

  2. SD-Pair Shell Model for Identical Nuclear Systems

    LUO Yan-An; PAN Feng; NING Ping-Zhi; Jerry P. Draayer


    @@ Typical spectra corresponding to vibrational, rotational and γ-soft cases were studied within the framework of nucleon-pair shell model truncated to SD-subspace. It is found that the three limiting cases all can be reproduced approximately. The analysis not only shows that the IBM indeed has a sound shell model foundation, but also confirms that the truncation scheme adopted in the SD-pair shell model seems to be reasonable.

  3. Photometric Survey to Search for Field sdO Pulsators

    Johnson, Christopher B; Wallace, S; O'Malley, C J; Amaya, H; Biddle, L; Fontaine, G


    We present the results of a campaign to search for subdwarf O (sdO) star pulsators among bright field stars. The motivation for this project is the recent discovery by Randall et al. (2011), of four rapidly pulsating sdO stars in the globular cluster Omega Cen, with Teff near 50,000 K, 5.4 -0.1 and similar temperatures and gravities. To date, we have found no detectable pulsations at amplitudes above 0.08% (4 times the mean noise level) in any of the 36 field sdO stars that we observed. The presence of pulsations in Omega Cen sdO stars and their apparent absence in seemingly comparable field sdO stars is perplexing. While very suggestive, the significance of this result is difficult to assess more completely right now due to remaining uncertainties about the temperature width and purity of the Omega Cen instability strip and the existence of any sdO pulsators with weaker amplitudes than the current detection limit in globular clusters.

  4. SD-CAS: Spin Dynamics by Computer Algebra System.

    Filip, Xenia; Filip, Claudiu


    A computer algebra tool for describing the Liouville-space quantum evolution of nuclear 1/2-spins is introduced and implemented within a computational framework named Spin Dynamics by Computer Algebra System (SD-CAS). A distinctive feature compared with numerical and previous computer algebra approaches to solving spin dynamics problems results from the fact that no matrix representation for spin operators is used in SD-CAS, which determines a full symbolic character to the performed computations. Spin correlations are stored in SD-CAS as four-entry nested lists of which size increases linearly with the number of spins into the system and are easily mapped into analytical expressions in terms of spin operator products. For the so defined SD-CAS spin correlations a set of specialized functions and procedures is introduced that are essential for implementing basic spin algebra operations, such as the spin operator products, commutators, and scalar products. They provide results in an abstract algebraic form: specific procedures to quantitatively evaluate such symbolic expressions with respect to the involved spin interaction parameters and experimental conditions are also discussed. Although the main focus in the present work is on laying the foundation for spin dynamics symbolic computation in NMR based on a non-matrix formalism, practical aspects are also considered throughout the theoretical development process. In particular, specific SD-CAS routines have been implemented using the YACAS computer algebra package (, and their functionality was demonstrated on a few illustrative examples.

  5. [SD-OCT contribution in congenital achromatopsia diagnosis (6 patients)].

    Largueche, L; Chebil, A; Bouladi, M; Bouraoui, R; Kort, F; Charfi, H; El Matri, L


    Achromatopsia (ACH) is a congenital autosomal recessive cone disorder. The puspose is to describe particular SD-OCT macular images in ACH. The study included 6 patients from 3 consanguineous Tunisian families with congenital nystagmus and amblyopia with ACH. All patients had clinical examination with fundus photography, autofluorescence, 100-Hue Color vision and the appearance and thickness of all retinal layers were evaluated by spectral-domain optical coherence tomography (SD-OCT). All patients had ACH. The feature was loss of inner- and outer-segments (IS/OS) with disruption of the ciliary layer on OCT and an appearance of partial-thickness hole in the outer macular retina. This feature seems to be characteristic of ACH. SD-OCT correlated to clinic signs help the diagnosis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  6. Listing of Approved Secretary of Defense (SD) Forms


    3E321, Pentagon Washington, DC 20301-1200 694-3242 ASD(LA) Mr. Stephen Bender ASD(Legislative Affairs) Director, R&A Room 3D932, Pentagon Washington...DC 20301-1300 697-3782 ASD(PA) COL Robert N. Seltzer ASD(Public Affairs) Room 2E811, Pentagon Washington, DC 20301-1400 697-5007 ASD(PA&E) Mrs. Eileen...A. PAGE DESCRIPTION OF MILITARY (202) 694-7044 PERSONNEL SD 59- 1 640701 DOCUMENT CONTROL ASD(PA) REFERENCE R. SELTZER (202) 697-5007 SD 59-12 551201

  7. Automated Segmentation of the Choroid from Clinical SD-OCT

    Zhang, Li; Lee, Kyungmoo; Niemeijer, Meindert; Mullins, Robert F.; Sonka, Milan; Michael D Abràmoff


    Aging and eye disease changes the choroid, but imaging it is hard. We describe a fully automated, highly reproducible, 3D method for segmentation of choroidal vessels, and quantification of choroidal and choriocapillaris-equivalent thickness, in standard clinical SD-OCT.

  8. 78 FR 48764 - South Dakota Disaster # SD-00061


    ... ADMINISTRATION South Dakota Disaster SD-00061 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY...: Submit completed loan applications to: U.S. Small Business Administration, Processing and Disbursement... of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite...


    Suhandi Astuti


    Full Text Available Identification conducted by the principle of SD Laboratory UKSW showed that the teachers were still not competent in doing learning assessment administration well. To solve these problems, the principal conducted academic supervision. The essence of the academic supervision is to help teachers develop professional capabilities. This was also done by the principle of SD Laboratory UKSW in solving problems related to the administration assessment of learning where there were some teachers in SD Laboratory UKSW not yet competent in preparing the learning assessment administration well. Supervision technique conducted by discussion. The result of supervision performed by principle of SD Laboratory UKSW showed an increasement. At the initial conditions the average level of competence of learning assessment administration preparation was 63.5 (ideal score of 100.  After given the action, the average of competence of learning assessment administration preparation was increased to 89.6. The data showed that the competence of learning assessment administration preparation has increased 26.2%.

  10. Bridging sd1 molecular knowledge with recent breeding strategies ...



    Apr 12, 2010 ... The sd1 allele present in 'IR8' is a null allele, containing a 383 bp ... 28, RH (%) = 60 and 12 h photoperiod). DNA extraction and PCR ... Comparison of plant height between seven breeding lines was done using Analysis of ...

  11. 75 FR 4417 - Wind Cave National Park, Custer County, SD


    ... Wind Cave National Park, Custer County, SD AGENCY: National Park Service. ACTION: Notice of... Statement, Wind Cave National Park, Custer County, South Dakota. SUMMARY: Pursuant to Section 102(2)(C) of... Environmental Impact Statement (Plan), Wind Cave National Park, Custer County, South Dakota. On December 3,...

  12. Many-Body Approximations in the sd-Shell Sandbox

    Sen'kov, R A; Brown, B A; Luo, Y L; Zelevinsky, V G


    A new theoretical approach is presented that combines the Hartree-Fock variational scheme with the exact solution of the pairing problem in the finite orbital space. Using this formulation in the sd-space as an example, we show that the exact pairing significantly improves the results for the ground state energy

  13. Microscopic calculations of C2 and C4 form factors in sd-shell nuclei

    Radhi, R A


    Inelastic electron scattering to 2 sup + and 4 sup + states for the even-even N=Z sd-shell nuclei ( sup 2 sup 0 Ne, sup 2 sup 4 Mg, sup 2 sup 8 Si and sup 3 sup 2 S) are discussed taking into account higher energy configurations outside the sd-shell. Higher energy configurations, which are called core polarization effects, are included through a microscopic theory that includes excitations from the core 1s and 1p orbits and also from 2s-1d shell to the higher allowed orbits with 2 Planck constant omega excitations. The predictions of C2 and C4 Coulomb form factors are compared with the available experimental data. The calculations based on the Wildenthal interaction for the sd-shell model space and on the modified surface delta interaction for the core-polarization effects. The effect of higher excited configurations is found essential in both the transition strength and momentum transfer dependence of form factors, and gives a remarkably good agreement with the measured data.

  14. Teratogenicity of vertilmicin in SD rats%威替米星对SD大鼠的致畸作用

    马玺里; 郑怡文; 朱玉平; 朱江波; 毕洁; 张天宝


    目的 探讨威替米星对妊娠期SD大鼠的胚胎毒性和致畸作用.方法 采用大鼠标准致畸试验,79只孕SD大鼠随机分为4组,每组19或20只.威替米星3个剂量组分别给予威替米星30.0、15.0、7.5 mg·kg-1,阴性对照组给予生理盐水,于妊娠d 6~15尾静脉注射给药,每日1次.妊娠d 20处死孕鼠,检查母体妊娠与胎鼠畸形情况.结果 威替米星各剂量组SD大鼠的孕鼠增重、活胎率、死胎率、吸收胎率和活胎身长与阴性对照组相比无显著差异(P>0.05).威替米星30.0 mg·kg-1组活胎体重、胎盘重量与阴性对照组比较有显著差异(P<0.05),但无明显的剂量-反应关系.各实验组均未观察到胎鼠明显的外观、脏器以及骨骼的畸形.结论 威替米星剂量≤30.0 mg·kg-1无明显的母体毒性和致畸作用,也无明显的胚胎毒性和胎儿毒性.

  15. Hepatotoxicity of heptaplatin and a new platinum complex LLC-0601 in SD rats%新型铂类化合物LLC-0601与舒铂对SD大鼠的肝毒性

    王振宇; 梅茸; 宋京风; 刘伟平; 陆瑛


    目的 观察新型铂类化合物LLC-D601与舒铂对SD大鼠的肝毒性,探讨其可能的毒性作用机制.方法 雄性SD大鼠尾静脉iv给予顺铂2mg·kg(阳性对照)、舒铂40 mg·kg、LLC-0601 40和70mg·kg,连续2 d,间隔5 d,共6次,末次给药后恢复期28 d,观察动物一般状况,并于给药末期和恢复28 d后检测血清谷丙转氨酶(GPT),谷草转氨酶(GOT),碱性磷酸酶(ALP),总蛋白(TP),白蛋白(ALB)和总胆红素(T-Bil),肝质量与系数,组织匀浆谷胱甘肽过氧化物酶(GSH-P),超氧化物歧化酶(T-SOD),微量丙二醛(MDA)及光学显微镜进行病理组织学检查.结果 与正常对照组相比,LLC-0601 40mg·kg组各项检测指标未见明显异常,其余给药组动物均出现精神差、少食、少动、竖毛、毛发无光泽以及体质量下降;给药末期血清生化检测舒铂组GPT升高,TP和ALB降低(P组肝质量明显降低(P组肝组织匀浆中GSH-PT和T-SOD降低,各给药组MDA均升高(P组肝病理组织学均出现不同程度肝细胞点灶状坏死,肝窦内淋巴细胞浸润,以舒铂组病变程度最重.恢复期顺铂组病理组织学病变较给药末期重,出现延迟性毒性反应,其余各给药组各项检测指标均基本恢复.结论 顺铂、舒铂和LLC-0601均可引起大鼠肝损伤,其机制与药物引起的组织过氧化损伤有关.%OBJECTIVE To investigate the hepatotoxicity of heptaplatin and LLC-0601 in SD rats, and to explore the toxic mechanisms. METHODS Rats were respectively injected with cisplatin 2 mg·kg-1 (positive control), heptaplatin 40 mg·kg-1 and LLC-0601 40 and 70 mg·kg-1,once a day, for 2 d, and then an inteval for 5 d, all 3 courses for 6 injections, and then rats restored for 28 d. After the last 24 h after administration and after restoration 28 d, the rats were inspected for their general condition. Serum biochemistry indices glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase(GOT), alkaline phosphatase(ALP), total

  16. What's the nature of sdA stars?

    Pelisoli, Ingrid; Koester, D; Romero, A D


    White dwarfs with log g lower than 7.0 are called Extremely Low Mass white dwarfs (ELMs). They were first found as companions to pulsars, then to other white dwarfs and main sequence stars (The ELM Survey: 2010 to 2016), and can only be formed in interacting binaries in the age of the Universe. In our SDSS DR12 white dwarf catalog (Kepler et al. 2016), we found a few thousand stars in the effective temperature and surface gravity ranges attributed to ELMs. We have called these objects sdAs, alluding to their narrow hydrogen line spectra showing sub-main sequence log g. One possible explanation for the sdAs is that they are ELMs. Increasing the ELMs sample would help constrain the number of close binaries in the Galaxy. Interestingly, if they turn out to be A stars with an overestimated log g, the distance modulus would put these young stars in the Galaxy's halo.

  17. Carbon abundances of sdO stars from SPY

    Hirsch, Heiko; Heber, Uli


    Ströer et al. (2007) recently suggested a classification of sdOs according to supersolar and subsolar helium abundances, with only the helium-enriched stars showing signes of carbon and/or nitrogen in their optical spectra. We aim to derive reliable carbon and nitrogen abundances by fitting synthetic spectra to data obtained with the UVES spectrograph at ESO. Here we present our first results of the analysis of carbon abundances in hot subdwarf O stars. By constructing a grid of model atmospheres consisting of hydrogen, helium and carbon we were able to derive atmospheric parameters of nine carbon rich sdOs. We find log(NC/Ntotal) up to ten times higher than the solar value, while the mean value for the effective temperature and the surface gravity is slightly lower than derived by helium-hydrogen models only. Surprisingly, we also find three fast rotators among our program stars.

  18. SD-OCT to distinguish papilledema from pseudopapilledema.

    Asensio-Sánchez, V M; Trujillo-Guzmán, L


    Two patients presented with headache and bilateral papillary edema. Patient 1 was found to have a papilledema (P) with intracranial pressure of 32cmH2O. Patient 2 was found to have a migraine with a pseudopapilledema (PP) (optic nerve head drusen). SD-OCT was used to image the optic disc, subretinal hyporeflective space (SHS), and alpha-angle (Aα). Optic disc SD-OCT may be useful for differentiating disc morphology in P and PP. The area of the SHS and the Aα were higher in the P patient than in the patient with PP. Copyright © 2014 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  19. Shell Model Depiction of Isospin Mixing in sd Shell

    Lam, Yi Hua; Smirnova, Nadya A. [CENBG (CNRS/IN2P3 - Universite Bordeaux 1) Chemin du Solarium, 33175 Gradignan (France); Caurier, Etienne [IPHC, IN2P3-CNRS et Universite Louis Pasteur, 67037 Strasbourg (France)


    We constructed a new empirical isospin-symmetry breaking (ISB) Hamiltonian in the sd(1s{sub 1/2}, 0d{sub 5/2} and 0d{sub 3/2}) shell-model space. In this contribution, we present its application to two important case studies: (i){beta}-delayed proton emission from {sup 22}Al and (ii) isospin-mixing correction to superallowed 0{sup +}{yields}0{sup +}{beta}-decay ft-values.

  20. SD1000 Collaboration: Hunting down the subdwarf populations

    Nemeth, Peter; Vos, Joris; Kawka, Adela; Vennes, Stephane


    Separating the subdwarf populations may shed light on their formation history and give unique insights into the atmospheric processes that are thought to be responsible for their abundance diversity. Such a task requires complex and time consuming spectral analyses, which we started to tailor to our objectives a year ago. Here we report the updates that have been made over the past year and will be the standard method in SD1000.

  1. sd(2) Graphene: Kagome band in a hexagonal lattice.

    Zhou, Miao; Liu, Zheng; Ming, Wenmei; Wang, Zhengfei; Liu, Feng


    Graphene, made of sp^{2} hybridized carbon, is characterized with a Dirac band, representative of its underlying 2D hexagonal lattice. The fundamental understanding of graphene has recently spurred a surge in the search for 2D topological quantum phases in solid-state materials. Here, we propose a new form of 2D material, consisting of sd^{2} hybridized transition metal atoms in hexagonal lattice, called sd^{2} "graphene." The sd^{2} graphene is characterized by bond-centered electronic hopping, which transforms the apparent atomic hexagonal lattice into the physics of a kagome lattice that may exhibit a wide range of topological quantum phases. Based on first-principles calculations, room-temperature quantum anomalous Hall states with an energy gap of ∼0.1  eV are demonstrated for one such lattice made of W, which can be epitaxially grown on a semiconductor surface of 1/3 monolayer Cl-covered Si(111), with high thermodynamic and kinetic stability.

  2. Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats.

    Luo, Qihui; Chen, Zhengli; Cheng, Anchun; Wang, Mingshu; Fang, Jing; Peng, Xi; Tang, Li


    Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6-15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6-20 pregnant days were significantly different (P changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.

  3. Automated Segmentation of the Choroid from Clinical SD-OCT

    Zhang, Li; Lee, Kyungmoo; Niemeijer, Meindert; Mullins, Robert F.; Sonka, Milan; Abràmoff, Michael D.


    Purpose. We developed and evaluated a fully automated 3-dimensional (3D) method for segmentation of the choroidal vessels, and quantification of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subjects using standard clinically available spectral domain optical coherence tomography (SD-OCT). Methods. A total of 24 normal subjects was imaged twice, using clinically available, 3D SD-OCT. A novel, fully-automated 3D method was used to segment and visualize the choroidal vasculature in macular scans. Local choroidal vasculature and choriocapillaris-equivalent thicknesses were determined. Reproducibility on repeat imaging was analyzed using overlapping rates, Dice coefficient, and root mean square coefficient of variation (CV) of choroidal vasculature and choriocapillaris-equivalent thicknesses. Results. For the 6 × 6 mm2 macula-centered region as depicted by the SD-OCT, average choroidal vasculature thickness in normal subjects was 172.1 μm (95% confidence interval [CI] 163.7–180.5 μm) and average choriocapillaris-equivalent thickness was 23.1 μm (95% CI 20.0–26.2 μm). Overlapping rates were 0.79 ± 0.07 and 0.75 ± 0.06, Dice coefficient was 0.78 ± 0.08, CV of choroidal vasculature thickness was 8.0% (95% CI 6.3%–9.4%), and of choriocapillaris-equivalent thickness was 27.9% (95% CI 21.0%–33.3%). Conclusions. Fully automated 3D segmentation and quantitative analysis of the choroidal vasculature and choriocapillaris-equivalent thickness demonstrated excellent reproducibility in repeat scans (CV 8.0%) and good reproducibility of choriocapillaris-equivalent thickness (CV 27.9%). Our method has the potential to improve the diagnosis and management of patients with eye diseases in which the choroid is affected. PMID:23060139

  4. Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes

    Feng-xiang ZHANG; Ming-long CHEN; Qi-jun SHAN; Jian-gang ZOU; Chun CHEN; Bing YANG; Dong-jie XU; Yu JIN; Ke-jiang CAO


    Aim: To investigate whether hypoxia reoxygenation induces premature senes-cence in neonatal Sprague-Dawley (SD) rat cardiomyocytes. Methods: Cardio-myocytes were isolated from neonatal SD rat heart and identified by immunohisto-chemistry. The control cultures were incubated at 37 ℃ in a humidified atmo-sphere of 5% CO and 95% air. The hypoxic cultures were incubated in a modular incubator chamber filled with 1% O2, 5% CO2, and balance N2 for 6 h. The reoxygen-ated cultures were subjected to 1% O2 and 5% CO2 for 6 h, then 21% oxygen for 4,8, 12, 24, and 48 h, respectively. Cell proliferation was determined using bromo-deoxyuridine labeling. The ultrastructure of cardiomyocytes was observed by using an electron microscope. Β-Galactosidase activity was determined by using a senescence β-galactosidase Staining Kit. P16INK4a and telomerase reverse tran-scriptase (TERT) mRNA levels were measured by real time quantitative PCR. TERT protein expression was determined by immunohistochemistry. Telomerase activi-ties were assayed by using the Telo TAGGG Telomerase PCR ELISApplus kit. Results:The initial cultures consisted of pure cardiomyocytes identified by immunohisto-chemistry. The proportion of BrdU positive cells was reduced significantly in the hypoxia reoxygenation-treated group (P<0.01). Under the condition of hypoxia reoxygenation, mitochondrial dehydration appeared; p16'INK4a and TERT mRNA levels, β-galactosidase activity, TERT protein expression and telomerase activi-ties were all significantly increased (P<0.01 or P<0.05). Conclusion: These data indicate that premature senescence could be induced in neonatal SD rat cardiomyo-cytes exposed to hypoxia reoxygenation. Although TERT significantly increased,it could not block senescence.

  5. On SD-oriented mechanism of technological innovation

    Yang Yuwen; Zhang Juyong


    If one enterprise just takes technological innovation as the way for economic profit but not the combinational profit of economy,society and ecology,it will never survive in this fierce competition market.Based on the relationship between technological innovation and sustainable development,this paper brings forward that technological innovation must take the sustainablel development of society as the fundamental goal.Technological innovation should be the real impulse for the development of society,economy and ecology.On the basis of the analysis on previous technologicalinnovation impetus mechanism,combined with the influential factors,this paper puts forward SD-oriented mechanism oftechnological innovation.

  6. Area SM12/SD12 - Reintegrated into the Meyrin Site

    Relations with the Host States Service


    Area SM12/SD12 near the Saint-Genis-Pouilly roundabout will be reintegrated into the Meyrin Site on Friday, 8 July at 2.00 p.m. From this date the area concerned will be accessible exclusively via the Route Siegbahn. The gate onto the main road RD 984 will be used exclusively for the exceptional loads of the LHC dipole cryomagnets under conditions laid down by the relevant authorities. Relations with the Host States Service and TS-IC Group

  7. Confinement orientation effects in S/D tunneling

    Medina-Bailon, C.; Sampedro, C.; Gámiz, F.; Godoy, A.; Donetti, L.


    The most extensive research of scaled electronic devices involves the inclusion of quantum effects in the transport direction as transistor dimensions approach nanometer scales. Moreover, it is necessary to study how these mechanisms affect different transistor architectures to determine which one can be the best candidate to implement future nodes. This work implements Source-to-Drain Tunneling mechanism (S/D tunneling) in a Multi-Subband Ensemble Monte Carlo (MS-EMC) simulator showing the modification in the distribution of the electrons in the subbands, and, consequently, in the potential profile due to different confinement direction between DGSOIs and FinFETs.

  8. Binary sdB Stars with Massive Compact Companions

    Geier, S; Edelmann, H; Heber, U; Napiwotzki, R


    The masses of compact objects like white dwarfs, neutron stars and black holes are fundamental to astrophysics, but very difficult to measure. We present the results of an analysis of subluminous B (sdB) stars in close binary systems with unseen compact companions to derive their masses and clarify their nature. Radial velocity curves were obtained from time resolved spectroscopy. The atmospheric parameters were determined in a quantitative spectral analysis. Based on high resolution spectra we were able to measure the projected rotational velocity of the stars with high accuracy. In the distribution of projected rotational velocities signs of tidal locking with the companions are visible. By detecting ellipsoidal variations in the lightcurve of an sdB binary we were able to show that subdwarf binaries with orbital periods up to 0.6 d are most likely synchronized. In this case, the inclination angles and companion masses of the binaries can be tightly constrained. Five invisible companions have masses that ar...

  9. SD45216:DC-DC转换器



  10. Determining the Energy Gap Between the sd-pf Neutron Shells in 25O

    Jones, Michael; Frank, Nathan; Deyoung, Paul; Baumann, Thomas; Kohley, Zach; Smith, Jenna; Spyrou, Artemis; Stiefel, Krystin; Kuchera, Anthony; Thoennessen, Michael; MoNA Collaboration


    The excited states of 25O, particularly those of negative parity, are of great interest for determining the evolution of the sd-pf shell gap in and around the ``island of inversion.'' Shell Model (WBBS) calculations tuned to nearby 27Ne predict the 3/2- state in 25O to be only 500 keV above the ground state, implying the sd-pf shell gap to be small. Hence it is likely for nuclei beyond N = 16 to have mixing between the 0d3/2 and 1p3/2 orbitals. A recent experiment, performed at the NSCL, populated 25O through use of a (d , p) reaction. Using the Ursinus College Liquid Hydrogen Target, an 24O beam impinged on a deuterium target cell with a thickness of 400 mg/cm2 at a rate of approximately 30 pps to produce 25O, which decayed immediately by neutron emission. The resulting charged fragments were bent by the Sweeper magnet into a suite of charged particle detectors, while the neutrons traveled unimpeded towards MoNA (Modular Neutron Array) and LISA (Large multi-Institutional Scintillator Array). Together, MoNA-LISA and the Sweeper provide a full kinematic measurement from which the decay energy of the 2-body system can be determined. Preliminary results will be discussed.

  11. Charge radii of magnesium isotopes by laser spectroscopy a structural study over the $sd$ shell

    Schug, M; Krieger, A R

    We propose to study the evolution of nuclear sizes and shapes over the magnesium chain by measuring the root-mean-square charge radii of $^{21 - 32}$Mg, essentially covering the entire $\\textit{sd}$ shell. Our goal is to detect the structural changes, which in the neutron-deficient isotopes may originate from clustering, in a way similar to neon, and on the neutron-rich side would characterize the transition to the "island of inversion". We will combine, for the first time, the sensitive $\\beta$-detection technique with traditional fluorescence spectroscopy for isotope-shift measurements and in such a way gain access to the exotic species near the ${N}$ = 8 and ${N}$ = 20 shell closures.

  12. Origin of fine structure of the giant dipole resonance in sd-shell nuclei

    Fearick, R W; Matsubara, H; von Neumann-Cosel, P; Richter, A; Roth, R; Tamii, A


    A set of high resolution zero-degree inelastic proton scattering data on 24Mg, 28Si, 32S, and 40Ca provides new insight into the long-standing puzzle of the origin of fragmentation of the Giant Dipole Resonance (GDR) in sd-shell nuclei. Understanding is provided by state-of-the-art theoretical Random Phase Approximation (RPA) calculatios for deformed nuclei using for the first time a realistic nucleon-nucleon interaction derived from the Argonne V18 potential with the unitary correlation operator method and supplemented by a phenomenological three-nucleon contact interaction. A wavelet analysis allows to extract significant scales both in the data and calculations characterizing the fine structure of the GDR. The fair agreement supports that the fine structure arises from ground-state deformation driven by alpha clustering.

  13. Heavy metals and lead isotopes in sdB stars

    O'Toole, S


    We present a detailed abundance analysis of high-resolution ultraviolet echelle spectra of five subdwarf B stars obtained with HST-STIS The goal of our observations was to test the hypothesis that pulsations in sdBs are correlated to the surface abundances of iron-group elements. We study two pulsators and three non-pulsators and determined abundances for 25 elements including the iron group and even heavier elements such as tin and lead using LTE spectrum synthesis techniques. We find strong enrichments of heavy elements up to 2.9dex with respect to solar which are probably caused by atomic diffusion processes. No clear-cut correlation between pulsations and metal abundances becomes apparent. Abundances for lead isotopes are derived from very high resolution spectra using an UV line of triply ionised lead. As Pb terminates the s-process sequence Pb isotopic abundance ratios yield important constraints. It is very difficult to measure them in hot stars. For the first time we were able to measure them in two s...

  14. Charge radii of neon isotopes across the sd neutron shell

    Marinova, K; Kowalska, M; Kotrotsios, G; Kloos, S; Neugart, R; Blaum, K; Simon, H; Keim, M; Lievens, P; Wilbert, S; Kappertz, S


    We report on the changes in mean square charge radii of unstable neon nuclei relative to the stable (20)Ne, based on the measurement of optical isotope shifts. The studies were carried out using collinear laser spectroscopy on a fast beam of neutral neon atoms. High sensitivity on short-lived isotopes was achieved thanks to nonoptical detection based on optical pumping and state-selective collisional ionization, which was complemented by an accurate determination of the beam kinetic energy. The new results provide information on the structural changes in the sequence of neon isotopes all across the neutron sd shell, ranging from the proton drip line nucleus and halo candidate (17)Ne up to the neutron-rich (28)Ne in the vicinity of the ``island of inversion.{''} Within this range the charge radius is smallest for (24)Ne with N = 14 corresponding to the closure of the neutron d(5/2) shell, while it increases toward both neutron shell closures, N = 8 and N = 20. The general trend of the charge radii correlates w...

  15. Identification of a New Marine Bacterial Strain SD8 and Optimization of Its Culture Conditions for Producing Alkaline Protease.

    Cui, Hongxia; Yang, Muyang; Wang, Liping; Xian, Cory J


    While much attention has been given to marine microorganisms for production of enzymes, which in general are relatively more stable and active compared to those from plants and animals, studies on alkaline protease production from marine microorganisms have been very limited. In the present study, the alkaline protease producing marine bacterial strain SD8 isolated from sea muds in the Geziwo Qinhuangdao sea area of China was characterized and its optimal culture conditions were investigated. Strain SD8 was initially classified to belong to genus Pseudomonas by morphological, physiological and biochemical characterizations, and then through 16S rDNA sequence it was identified to be likely Pseudomonas hibiscicola. In addition, the culture mediums, carbon sources and culture conditions of strain SD8 were optimized for maximum production of alkaline protease. Optimum enzyme production (236U/mL when cultured bacteria being at 0.75 mg dry weight/mL fermentation broth) was obtained when the isolate at a 3% inoculum size was grown in LB medium at 20 mL medium/100mL Erlenmeyer flask for 48h culture at 30°C with an initial of pH 7.5. This was the first report of strain Pseudomonas hibiscicola secreting alkaline protease, and the data for its optimal cultural conditions for alkaline protease production has laid a foundation for future exploration for the potential use of SD8 strain for alkaline protease production.

  16. Product of the SNPP VIIRS SD screen transmittance and the SD BRDF from both yaw maneuver and regular on-orbit data

    Lei, Ning; Xiong, Xiaoxiong


    To assure data quality, the Earth-observing Visible Infrared Imaging Radiometer Suite (VIIRS) regularly performs on orbit radiometric calibrations of its 22 spectral bands. The primary calibration radiance source for the reflective solar bands (RSBs) is a sunlit solar diffuser (SD). During the calibration process, sunlight goes through a perforated plate (the SD screen) and then strikes the SD. The SD scattered sunlight is used for the calibration, with the spectral radiance proportional to the product of the SD screen transmittance and the SD bidirectional reflectance distribution function (BRDF). The BRDF is decomposed to the product of its value at launch and a numerical factor quantifying its change since launch. Therefore, the RSB calibration requires accurate knowledge of the product of the SD screen transmittance and the BRDF (RSB; launch time). Previously, we calculated the product with yaw maneuver data and found that the product had improved accuracy over the prelaunch one. With both yaw maneuver and regular on orbit data, we were able to improve the accuracy of the SDSM screen transmittance and the product for the solar diffuser stability monitor SD view. In this study, we use both yaw maneuver and a small portion of regular on-orbit data to determine the product for the RSB SD view.


    Jamaluddin Jamaluddin


    Full Text Available Abstract: Elementary School Studens' Creative Thinking Skills in Science Learning. This study aims (1 to investigate the differences of creative thinking skills among elementary school students who applied various learning methods (questioning, Think-Pair-Share, and Numbered-Head together and those who applied conventional learning methods; (2 to find out the differences in creative thinking skills between students of high and low academic ability; (3 to investigate the differences of creative thinking skills as influ­enced by learning methods and academic ability. Using a quasi -experimental design, this study found out that there are differences in creative thinking skills among students applying different learning methods and among students of different academic abilities and that these differences in creative thinking are skills as influenced by learning methods and academic abilities. Abstrak: Kemampuan Berpikir Kreatif Siswa SD dalam Pembelajaran IPA. Artikel ini didasarkan pada laporan penelitian yang bertujuan untuk mengetahui (1 perbedaan keterampilan berpikir kreatif, antara siswa yang belajar dengan strategi pembelajaran PBMP, PBMPTPS, PBMPNHT, dan strategi pembelajaran konvensional; (2 perbedaan keterampilan berpikir kreatif siswa berkemampuan akademik tinggi dan rendah; (3 perbedaan keterampilan berpikir kreatif akibat dari interaksi antara strategi pembelajaran dengan kemampuan akademik siswa. Hasil penelitian menunjukkan (1 ada perbedaan keterampilan berpikir kreatif antara siswa yang belajar dengan strategi PBMP, PBMPTPS, PBMPNHT, dan strategi Konven­sional; (2 ada perbedaan keterampilan berpikir kreatif, antara siswa berkemampuan akademik tinggi dengan siswa berkemampuan akademik rendah; (3 interaksi strategi pembelajaran PBMP, PBMP.TPS, PBMP.NHT, dan konvensional dengan kemampuan akademik siswa tidak berpengaruh signifikan terhadap keterampilan berpikir kreatif.

  18. Preparation and evaluation of kaempferol-phospholipid complex for pharmacokinetics and bioavailability in SD rats.

    Zhang, Kexia; Gu, Liqiang; Chen, Jinpeng; Zhang, Yuanyuan; Jiang, Yu; Zhao, Longshan; Bi, Kaishun; Chen, Xiaohui


    As one of the dietary flavonoids, kaempferol (KP) has been well known to show strong anti-oxidative effect along with other biological properties. However, the oral bioavailability of KP is relatively low due to its poor solubility. In this study, we intended to increase the solubility and bioavailability of KP by preparing kaempferol-phospholipid complex (KP-PC). The KP-PC's physicochemical properties were characterized in terms of infrared spectroscopy (IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD), water/n-Octanol solubility and in vitro dissolution. KP-PC exhibited higher solubility and dissolution rate than KP, indicating a significant improvement in hydrophilicity. A UPLC-ESI-MS/MS method was developed and validated for the determination of KP in Sprague-Dawley (SD) rat plasma, so as to investigate the oral bioavailability of KP-PC versus KP. Results showed that Cmax and AUC(0-48 h) of KP from the complex (Cmax: 3.94 ± 0.83 μg/mL, AUC(0-48 h): 57.81 ± 9.43 mg/Lh) were higher than that of KP (Cmax: 1.43 ± 0.21 μg/mL, AUC(0-48 h): 13.65 ± 3.12 mg/Lh). This research indicated that phospholipid complex (PC) might be one of the suitable approachs to improve the oral bioavailability of KP and other poor-solubility flavonoids.

  19. The incidence of HLA-SD antigens in recessive retinitis pigmentosa.

    Chen, M C; Marak, G E; Pilkerton, A R


    Eighteen patients with recessive retinitis pigmentosa were tissue typed for HLA-SD antigens. There was no evidence that a particular HLA-SD antigen was associated with autosomal recessive retinitis pigmentosa. PMID:638110


    Jayanti Putri Purwaningrum


    Full Text Available Abstrak. Penelitian ini bertujuan untuk mengkaji: (1 perbedaan rata-rata antara hasil tes kemampuan koneksi matematis siswa dengan Kriteria Kentutasan Maksimum (KKM pada siswa yang belajar melalui circuit learning; (2 kemampuan koneksi matematis siswa yang belajar melalui circuit learning mencapai ketuntasan klasikal 75%; (3 circuit learning dapat meningkatkan kemampuan koneksi matematis siswa; dan (4 respon siswa tehadap pembelajaran matematika melalui circuit learning. Metode penelitian yang digunakan adalah pre experimental design, dengan desain one group pretest-posttest. Subjek dalam penelitian ini adalah siswa-siswi kelas IV pada salah satu SD di Kabpuaten Kudus dengan banyaknya siswa adalah 20 siswa. Instrumen penelitian yang digunakan yaitu tes kemampuan koneksi matematis, perangkat pembelajaran, skala sikap siswa dan lembar observasi. Hasil penelitian menyatakan: (1 terdapat perbedaan rata-rata antara hasil tes kemampuan koneksi matematis siswa dengan Kriteria Kentutasan Maksimum (KKM pada siswa yang belajar melalui circuit learning; (2 kemampuan koneksi matematis siswa yang belajar melalui circuit learning mencapai ketuntasan klasikal 75%; (3 circuit learning dapat meningkatkan kemampuan koneksi matematis siswa; dan (4 siswa merespon positif tehadap pembelajaran matematika melalui circuit learning.  Kata Kunci: Kemampuan Koneksi Matematis, Circuit Learning Abstract. This study aims to assess: (1 the different average between the results of students' mathematic connection ability test with the Kriteria Kentutasan Maksimum (KKM on students who learn through the learning circuit; (2 the ability of students mathematic connections who learn through circuit learning reaches classical completeness 75%; (3 circuit learning can improve students' mathematic connections ability; and (4 the students’ respons of learning mathematics through circuit learning. The method of the research used is pre experimental design, with one group pretest

  1. Penerapan Metoda Serial Peripheral Interface (SPI pada Rancang Bangun Data Logger berbasis SD card



    Full Text Available ABSTRAK Serial Peripheral Interface (SPI adalah protokol komunikasi yang dapat digunakan sebagai interface komunikasi antara mikrokontroler dengan SD Card. Dengan menerapkan metoda SPI pada data logger berbasis SD Card, maka dapat diketahui karakteristik protokol komunikasi SPI antara mikrokontroler dengan SD Card. SD Card diformat dengan tipe FAT 16, dan data di dalam SD Card berupa sekumpulan paket data sensor yang diambil secara periodik dan disimpan dalam bentuk file dengan format.csv. Berdasarkan format paket data sensor yang dibuat, dapat dihitungwaktu perekaman data yang diperlukan agar kapasitas SD Card terisi penuh oleh data sensor. Hasil penelitian menunjukkan,bahwa metoda SPI yang diterapkan pada penelitian ini memiliki sifat akan melakukan pemeriksaan berulang pada pin MISO terhadap command yang dikirimkan oleh mikrokontroler melalui pin MOSI. Proses read/write data pada SD Card data logger memiliki keberhasilan 100%, karena SD Card telah terinisialisasi dalam mode SPI melalui perintah reset dan init SD Card. Komunikasi ini dapat dilakukan dengan menggunakan crystal 4 Mhz – 20 Mhz. Untuk pengujian konfigurasi SPI, hanya Independent Slave Configuration yang dapat digunakan pada komunikasi SPI dengan 2 SD card sebagai slave. Kata kunci: Serial Peripheral Interface (SPI, Data Logger, SD card, FAT16 ABSTRACT Serial Peripheral Interface (SPI is a communication protocol that can be applied as a communication interface between microcontroller to SD Card. By implementing the SPI method to a data logger based on SD Card, it can be known the characteristics of the SPI communications protocol between microcontroller to SD Card. SD Card formatted in FAT 16 type, and data on the SD Card is the form of sensor data packets collection which be captured periodically and saved in .csv format file. Based on the sensor data packet format is created, it can be calculated recording time data required so that the SD Card capacity completely filled by the

  2. Improved hybrid genome assemblies of 2 strains of Bacteroides xylanisolvens SD-CC-1b and SD-CC-2a using Illumina and 454 sequencing technologies

    Bacteroides xlyanisolvens strains (SD_CC_1b, SD_CC_2a) isolated from human feces were able to grow on crystalline cellulose. Cellulolytic properties are not common in Bacteroides species. Here, we report improved genome sequences of both the B. xlyanisolvens strains....



    Penelitian ini bertujuan untuk mendeskripsikan kesiapan guru Sekolah Dasar (SD) dalam menerapkan Kurikulum 2013 khususnya dalam pembelajaran tematik-integratif di Daerah Istimewa Yogyakarta (DIY). Jenis penelitian yang digunakan yaitu penelitian survei. Populasi penelitian adalah guru kelas I dan IV yang terdapat di wilayah DIY. Jumlah sampel yang diambil dalam penelitian ini adalah sebanyak 182 guru SD yang berasal dari 49 SD negeri dan 15 SD swasta yang dijadikan pilot project berdasarkan d...

  4. Anti-jugular vein thrombotic effect of Morinda citrifolia L. [noni] in male SD rats

    Mian-Ying Wang


    Full Text Available Background: Venous thromboembolism (VTE is a common and serious medical condition, which is estimably responsible for more than 300,000 hospital admissions annually in the USA. Pulmonary embolism (PE is a major complication of VTE, which contributes to 12% death of hospitalized patients. Heparin is the most common anti-coagulant, but severe allergic reactions, bleeding, and thrombocytopenia limit its use. Thus, seeking a botanical, nontoxic antithrombotic alternative is an interesting area. Morinda citrifolia L. [noni] is a medicinal plant used in folk remedies by Polynesians for over 2,000 years. It has been reported to have a broad range of therapeutic and preventive effects. The bioactivities of NJ have been continuously discovered with antioxidative, anti-inflammatory, analgesic, and immune modifying activities. Our novel hypothesis is whether NJ has an anti-venous thrombotic effect in rodents. To examine our hypothesis, this study was designed to examine the anti-thrombotic effect of NJ on the jugular vein thrombosis model induced by ferric chloride in SD rats.Material and Methods: NJ and placebo used in this study were donated by Morinda Holding Inc. NJ was formulated with grape juice and blue berry juice. Placebo was prepared by using the same procedure of NJ preparation, but without NJ in it. Thirty-six male SD rats were divided into six groups. Anti-venous thrombotic activities of 5% NJ, 10% NJ, heparin, and 10% NJ plus heparin were examined and compared with the positive and blank controls. Thrombosis was induced by application of a filter paper soaked in 50% ferric chloride on the right jugular vein. AFunctional Foods in Health and Disease 2011; 9:297-3092-cm fragment of the occluded vein (thrombus was removed and weighed after 1-hour maturation. Blood samples were collected for platelet count, aPTT, and PT tests.Results: The weight of a 2-cm fragment of normal jugular vein was 9.9 ± 2.1 mg, while the weight of the occluded vein in

  5. Alleviating anastrozole induced bone toxicity by selenium nanoparticles in SD rats

    Vekariya, Kiritkumar K.; Kaur, Jasmine; Tikoo, Kulbhushan, E-mail:


    Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompany the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when given in conjugation to anastrozole, lower the bone toxicity caused by anastrozole and thus reduce the probable damage to the bone. Selenium nanoparticles at a dose of 5 μg/ml significantly reduced the cell death caused by anastrozole (1 μM) in HOS (human osteoblast) cells. In addition, our results also highlighted that in female SD rat model, SeNPs (0.25, 0.5, 1 mg/kg/day) significantly prevented the decrease in bone density and increase in biochemical markers of bone resorption induced by anastrozole (0.2 mg/kg/day) treatment. Histopathological examination of the femurs of SeNP treated group revealed ossification, mineralization, calcified cartilaginous deposits and a marginal osteoclastic activity, all of which indicate a marked restorative action, suggesting the protective action of the SeNPs. Interestingly, SeNPs (1 mg/kg/day) also exhibited protective effect in ovariectomized rat model, by preventing osteoporosis, which signifies that bone loss due to estrogen deficiency can be effectively overcome by using SeNPs. - Highlights: ► SeNPs significantly reduce bone toxicity in anastrozole treated rats. ► SeNPs successfully prevented osteoporosis in ovariectomized rats. ► SeNP treatment lowered the levels of TRAP and increased the levels of ALKP.

  6. Fine mapping of a semidwarf gene sd-g in indica rice (Oryza sativa L.)

    LIANG Guohua; CAO Xiaoying; SUI Jiongming; ZHAO Xiangqiang; YAN Changjie; YI Chuandeng; GU Minghong


    The semidwarf gene sd-g which has been used in indica rice breeding in southern China is a new one, nonallelic to sd-1. To map sd-g, an F2 population derived from the cross between Xinguiaishuangai and 02428 was constructed. The sd-g was roughly mapped between two microsatellite markers RM440 and RM163, with genetic distances of 0.5 and 2.5 cM, respectively. Then nine new polymorphic microsatellite markers were developed in this region. The sd-g was further mapped between two microsatellite markers SSR5-1 and SSR5-51, with genetic distances of 0.1 and 0.3 cM, respectively, while cosegregated with SSR418. A BAC contig was found to span the sd-g locus, the region being delimited to 85 kb. This result was very useful for cloning of the sd-g gene.

  7. New excited states in sd-shell nucleus {sup 33}P

    Fu, B.; Reiter, P.; Arnswald, K.; Hess, H.; Hirsch, R.; Lewandowski, L.; Schneiders, D.; Seidlitz, M.; Siebeck, B.; Steinbach, T.; Vogt, A.; Wendt, A.; Wolf, K. [Institut fuer Kernphysik, Universitaet zu Koeln (Germany)


    Isospin-symmetry breaking in nuclear physics is mainly described by Mirror-Energy Differences (MED) for mirror nuclei or Triplet-Energy Differences (TED) for isobaric triplets. Modified USD-calculations successfully reproduce MED for T=1,3/2,2 sd-shell nuclei. Refined tests of theory are given by lifetime measurements in order to deduce transition-strength values. In order to study the mirror pair {sup 33}Ar and {sup 33}P, the fusion-evaporation reaction {sup 13}C+{sup 26}Mg at 46 MeV was measured at the Cologne tandem accelerator and the HORUS spectrometer employing the Doppler-Shift-Attenuation-Method (DSAM). First results yielded new γ-ray transitions in {sup 33}P and {sup 33}S. The level scheme of {sup 33}P was extended up to excitation energies of 10 MeV. Spins and parities of the new levels were determined exploiting γγ-angular correlations. Together with values from the proton-rich T{sub z} = - 3/2 partner, the levels are compared to shell model calculations, describing excitation energies of sd -shell mirror pairs. The understanding of isospin symmetry and isospin-symmetry breaking is a fundamental question in nuclear physics. Isospin-symmetry breaking is mainly described by Mirror-Energy Differences (MED) for mirror nuclei or Triplet-Energy Differences (TED) for isobaric triplets. Modified USD{sup m}{sub 1,2,3}-calculations successfully reproduced MED for the mirror nuclei {sup 33}Ar and {sup 33}P. Both {sup 33}P and {sup 33}S were produced at the Cologne FN tandem accelerator employing the fusion-evaporation reaction {sup 13}C+{sup 26}Mg at 46 MeV and spectroscopically investigated using 14 HPGe detectors. Several new energy states (in {sup 33}P) and γ-ray transitions (in {sup 33}P and {sup 33}S) were detected. Spins and parities of the new levels in {sup 33}P were determined exploiting γγ-angular correlations. The level scheme of {sup 33}P was extended up to excitation energies of 10 MeV.

  8. Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference.

    He, Xinyi; Hull, Victoria; Thomas, Julie A; Fu, Xiaoqing; Gidwani, Sonal; Gupta, Yogesh K; Black, Lindsay W; Xu, Shuang-yong


    The first reported Type IV restriction endonuclease (REase) GmrSD consists of GmrS and GmrD subunits. In most bacteria, however, the gmrS and gmrD genes are fused together to encode a single-chain protein. The fused coding sequence for ECSTEC94C_1402 from E. coli strain STEC_94C was expressed in T7 Express. The protein designated as Eco94GmrSD displays modification-dependent ATP-stimulated REase activity on T4 DNA with glucosyl-5-hydroxymethyl-cytosines (glc-5hmC) and T4gt DNA with 5-hydroxymethyl-cytosines (5hmC). A C-terminal 6xHis-tagged protein was purified by two-column chromatography. The enzyme is active in Mg(2+) and Mn(2+) buffer. It prefers to cleave large glc-5hmC- or 5hmC-modified DNA. In phage restriction assays, Eco94GmrSD weakly restricted T4 and T4gt, whereas T4 IPI*-deficient phage (Δip1) were restricted more than 10(6)-fold, consistent with IPI* protection of E. coli DH10B from lethal expression of the closely homologous E. coli CT596 GmrSD. Eco94GmrSD is proposed to belong to the His-Asn-His (HNH)-nuclease family by the identification of a putative C-terminal REase catalytic site D507-H508-N522. Supporting this, GmrSD variants D507A, H508A, and N522A displayed no endonuclease activity. The presence of a large number of fused GmrSD homologs suggests that GmrSD is an effective phage exclusion protein that provides a mechanism to thwart T-even phage infection.

  9. Mercury(II) and methyl mercury speciation on Streptococcus pyogenes loaded Dowex Optipore SD-2

    Tuzen, Mustafa, E-mail: [Gaziosmanpasa University, Faculty of Science and Arts, Chemistry Department, 60250 Tokat (Turkey); Uluozlu, Ozgur Dogan [Gaziosmanpasa University, Faculty of Science and Arts, Chemistry Department, 60250 Tokat (Turkey); Karaman, Isa [Gaziosmanpasa University, Faculty of Science and Arts, Biology Department, 60250 Tokat (Turkey); Soylak, Mustafa [Erciyes University, Faculty of Science and Arts, Chemistry Department, 38039 Kayseri (Turkey)


    A solid phase extraction procedure based on speciation of mercury(II) and methyl mercury on Streptococcus pyogenes immobilized on Dowex Optipore SD-2 has been established. Selective and sequential elution with 0.1 mol L{sup -1} HCl for methyl mercury and 2 mol L{sup -1} HCl for mercury(II) were performed at pH 8. The determination of mercury levels was performed by cold vapour atomic absorption spectrometry (CVAAS). Optimal analytical conditions including pH, amounts of biosorbent, sample volumes, etc., were investigated. The influences of the some alkaline and earth alkaline ions and some transition metals on the recoveries were also investigated. The capacity of biosorbent for mercury(II) and methyl mercury was 4.8 and 3.4 mg g{sup -1}. The detection limit (3 sigma) of the reagent blank for mercury(II) and methyl mercury was 2.1 and 1.5 ng L{sup -1}. Preconcentration factor was calculated as 25. The relative standard deviations of the procedure were below 7%. The validation of the presented procedure is performed by the analysis of standard reference material (NRCC-DORM 2 Dogfish Muscle). The procedure was successfully applied to the speciation of mercury(II) and methyl mercury in natural water and environmental samples.

  10. Mercury(II) and methyl mercury speciation on Streptococcus pyogenes loaded Dowex Optipore SD-2.

    Tuzen, Mustafa; Uluozlu, Ozgur Dogan; Karaman, Isa; Soylak, Mustafa


    A solid phase extraction procedure based on speciation of mercury(II) and methyl mercury on Streptococcus pyogenes immobilized on Dowex Optipore SD-2 has been established. Selective and sequential elution with 0.1 mol L(-1) HCl for methyl mercury and 2 mol L(-1) HCl for mercury(II) were performed at pH 8. The determination of mercury levels was performed by cold vapour atomic absorption spectrometry (CVAAS). Optimal analytical conditions including pH, amounts of biosorbent, sample volumes, etc., were investigated. The influences of the some alkaline and earth alkaline ions and some transition metals on the recoveries were also investigated. The capacity of biosorbent for mercury(II) and methyl mercury was 4.8 and 3.4 mg g(-1). The detection limit (3 sigma) of the reagent blank for mercury(II) and methyl mercury was 2.1 and 1.5 ng L(-1). Preconcentration factor was calculated as 25. The relative standard deviations of the procedure were below 7%. The validation of the presented procedure is performed by the analysis of standard reference material (NRCC-DORM 2 Dogfish Muscle). The procedure was successfully applied to the speciation of mercury(II) and methyl mercury in natural water and environmental samples.

  11. Optimization of a bioactive exopolysaccharide production from endophytic Fusarium solani SD5.

    Mahapatra, Subhadip; Banerjee, Debdulal


    Endophytic fungi were less investigated for exopolysaccharide production. In this study endophytic Fusarium solani SD5 was used for optimization of exopolysaccharide production. One variable at a time method and response surface methodology were employed to explore the optimum medium compositions and fermentation conditions. The organism produced maximum exopolysaccharide after 13.68 days of incubation at 28 °C in potato dextrose broth supplemented with (g%/l) glucose, 9.8; yeast extract, 0.69; KCl, 0.05; KH₂PO₄, 0.05 with medium pH 6.46. Use of 50 ml medium in 250 ml Erlenmeyer flask gives highest exopolysaccharide production. The organism produced more than two times higher exopolysaccharide (2.276 ± 0.032 g/l EPS) at optimized condition compared to pre-optimized condition (0.96 ± 0.021). In vivo toxicity test established nontoxic nature of the EPS (≤400 mg EPS/Kg of body weight). The EPS slightly altered intestinal indigenous bacteria and influenced the growth of beneficial Lactobacillus spp. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Interaction of a human blood group Sd(a-) Tamm-Horsfall glycoprotein with applied lectins.

    Wu, J H; Watkins, W M; Chen, C P; Song, S C; Wu, A M


    Unlike the human blood group Sd(a+) Tamm-Horsfall glycoprotein (THGP), the Sd(a-) one lacks terminal GalNAcbeta1--> residues at the nonreducing ends. The binding properties of this glycoprotein and its asialo product with lectins were characterized by quantitative precipitin (QPA) and precipitin inhibition assays. Among 20 lectins tested by QPA, both native and asialo Sd(a-) THGP reacted best with Abrus precatorius and Ricinus communis and completely precipitated the lectin added. They also precipitated well Wistaria floribunda (WFA), Glycine max (SBA), Bauhinia purpurea alba, abrin-a and ricin, all of which recognize the Galbeta1--> 4GlcNAcbeta1--> sequence, although at different strength. The lectin-glycan interactions were inhibited by Galbeta1--> 4GlcNAc and Galbeta1--> 4Glc. When the precipitability of Sd(a-) THGP was compared with that of the Sd(a+) phenotype, the native Sd(a-) THGP exhibited a 40% lesser affinity for WFA, SBA, WGA and mistletoe lectin-I (ML-I). Mapping the precipitation and inhibition profiles of the present study and the results of THGP Sd(a+), it is concluded that Sd(a-) THGP showed a strongly diminished affinity for GalNAcbeta1--> active lectins (SBA and WFA) than the Sd(a+) phenotype.


    Taufik Muhtarom


    Full Text Available Penelitian ini bertujuan untuk: (1 mengetahui perbedaan budaya sekolah di SDSN dan SD Eks RSBI DIY, (2 memaparkan perbedaan masing-masing aspek budaya sekolah antara SDSN dengan SD Eks RSBI. Jenis penelitian ini adalah komparasi. Populasi penelitian ini adalah semua kepala sekolah, guru, dan staf SDSN dan SD RSBI di Daerah Istimewa Yogyakarta yang berjumlah 797 orang untuk SDSN dan 155 orang untuk SD Eks RSBI. Sampel dari SDSN berjumlah 256 orang dan sampel dari SD Eks RSBI sebanyak 116 orang ditentukan menggunakan teknik proportional sampling. Pengumpulan data dilakukan menggunakan kuesioner. Teknik analisis data yang digunakan adalah analisis univariat, bivariat, dan uji-t. Hasil penelitian ini menunjukkan bahwa: (1 tidak terdapat perbedaan yang signifikan antara budaya sekolah SDSN dengan SD Eks RSBI di Daerah Istimewa Yogyakarta; (2 ditemukan perbedaan skor dari masing-masing aspek budaya sekolah di SDSN dan SD Eks RSBI DIY. Aspek budaya sekolah yang lebih baik di SDSN adalah kolaborasi profesional, hubungan kolegial, self determination, visi-misi, konsensus, dan disiplin. Sedangkan aspek budaya sekolah yang lebih unggul pada SD Eks RSBI adalah aspek komitmen, hormat, empati, bebas bullying dan artefak fisik. Kata kunci: budaya sekolah, SDSN, SD Eks RSBI

  14. Mineralogic variation in drill holes USW NRG-6, NRG-7/7a, SD-7, SD-9, SD-12, and UZ{number_sign}14: New data from 1996--1997 analyses

    Chipera, S.J.; Vaniman, D.T.; Bish, D.L.; Carey, J.W.


    New quantitative X-ray diffraction (QXRD) mineralogic data have been obtained for samples from drill holes NRG-6, NRG-7/7A, SD-7, SD-9, SD- 12, and UZ{number_sign}14. In addition, new QXRD analyses were obtained on samples located in a strategic portion of drill hole USW H-3. These data improve our understanding of the mineral stratigraphy at Yucca Mountain, and they further constrain the 3-D Mineralogic Model of Yucca Mountain. Some of the unexpected findings include the occurrence of the zeolite chabazite in the vitric zone of USW SD-7, broad overlap of vitric and zeolitic horizons (over vertical ranges up to 70 m), and the previously unrecognized importance of the bedded tuft beneath the Calico Hills Formation as a subunit with generally more extensive zeolitization than the Calico Hills Formation in the southern part of the potential repository area. Reassessment of data from drill hole USW H-5 suggests that the zeolitization of this bedded unit occurs in the northwestern part of the repository exploration block as well. Further analyses of the same interval in USW H-3, however, have not permitted the same conclusion to be reached for the southwestern part of the repository block because of the much poorer quality of the cuttings in H-3 compared with those from H-5. X-ray fluorescence (XRF) chemical data for drill holes USW SD-7, 9, and 12 show that the zeolitic horizons provide a >10 million year record of retardation of Sr transport, although the data also show that simplistic models of one-dimensional downward flow in the unsaturated zone (UZ) are inadequate. Complex interstratification of zeolites and glass, with highly variable profiles between drill cores, point to remaining problems in constructing detailed mineral stratigraphies. However, the new data in this report provide important information for constructing bounding models of zeolite stratigraphy for transport calculations.

  15. 77 FR 68716 - Proposed Amendment of Class E Airspace; Hot Springs, SD


    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Hot Springs, SD...: This action proposes to amend Class E airspace at Hot Springs, SD. Additional controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAPs) at Hot Springs...

  16. 78 FR 14911 - Amendment of Class E Airspace; Hot Springs, SD


    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Hot Springs, SD AGENCY... airspace at Hot Springs, SD. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures at Hot Springs Municipal Airport. The FAA is taking...

  17. Automated Segmentability Index for Layer Segmentation of Macular SD-OCT Images

    Lee, K.; Buitendijk, G.H.; Bogunovic, H.; Springelkamp, H.; Hofman, A.; Wahle, A.; Sonka, M.; Vingerling, J.R.; Klaver, C.C.W.; Abramoff, M.D.


    PURPOSE: To automatically identify which spectral-domain optical coherence tomography (SD-OCT) scans will provide reliable automated layer segmentations for more accurate layer thickness analyses in population studies. METHODS: Six hundred ninety macular SD-OCT image volumes (6.0 x 6.0 x 2.3 mm3) we

  18. U(5)-O(6) Phase Transition in the SD-Pair Shell Model

    WANG Fu-Rong; LIU Lin; LUO Yan-An; PAN Feng; DRAAYER J. P.


    U(5)-O(6) transitional behaviour in the SD-pair shell model is studied. The results show that the U(5)-O(6) transitional patterns of the interacting boson model can be reproduced in the SD-pair shell model approximately.

  19. Cytogenetic Analysis of an SD Chromosome from a Natural Population of DROSOPHILA MELANOGASTER

    Trippa, G.; Loverre, A.; Cicchetti, R.


    The discovery and the cytogenetic characterization of a new SD (Segregation Distorter) chromosome 2 from a natural population in Ranna (Sicily, Italy), SDRa, are reported. The main features of this chromosome are as follows: (a) it contains an SdRa gene with a moderate degree of segregation distortion (k = 0.72), (b) a recessive female sterile gene, fs(2)TLM, responsible for modifications of the morphology and structure of the tests and ovaries is located at 89.7, (c) SDRa/SDRa males and females are viable but sterile, the females due to homozygosis of fs(2)TLM and the males because of homozygosis of a region containing the Sd locus, and (d) SDi/SDj combinations are fertile, thus suggesting that the different Sd factors found in natural populations constitute a multiple allelic series.—These data may indicate that each population containing SD chromosomes has evolved its own genetic architecture for the complex SD system, with specific modifiers and perhaps different Sd genes. The possibility of reconstructing the evolutionary pattern of the SDRa chromosome in the natural Ranna population after the model of Charlesworth and Hartl (1978) and Crow (1979) is considered. PMID:17249043

  20. A generating functional approach to the sd-model with strong correlations



    Full Text Available A Kadanoff-Baym-type generating functional approach, earlier developed by the authors to strongly correlated systems, is applied to the sd-model with strong sd-coupling. Formalism of the Hubbard X-operators was used, and equation for electron Green's function was derived with functional derivatives over external fluctuating fields. Iterations in this equation generate a perturbation theory near the atomic limit. Hartree-Fock type approximation is developed within the framework of this theory, and the problem of a metal-insulator phase transition in sd-model is discussed.

  1. Learning from CDM SD tool experience for Article 6.4 in the Paris Agreement

    Olsen, Karen Holm


    are achieved in an integrated fashion and trade-offs avoided. Article 6.4 of the PA introduces a new Sustainable Mitigati on Mechanism (SMM) with the dual aim to contribute to the mitigation of greenhouse gas emissions and foster SD. The Kyoto Protocol’s Clean Development Mechanism (CDM) has a similar...... and multilateral standards to provide recommendations for improvement. A key conclusion is that the Paris Agreement’s SMM has a stronger political mandate than the CDM to measure that SD impacts are 'real, measurable and long-term'. Therefore, recommendations for an improved CDM SD tool are a relevant starting...

  2. 国产SD-V型甲板敷料的开发与应用



    This paper describes the performances, technical specifications, structural forms and applying techniques of SD-V deck auxiliary materials. As the real applications onboard show, the domestic deck auxiliary materials have good prospects on further development and application.

  3. [Lake Andes Wetland Management District: Aerial Photograph of Easement 38x in Hyde County, SD, 1984

    US Fish and Wildlife Service, Department of the Interior — This oblique aerial photograph from the Lake Andes Wetland Management District was taken from Easement 38x (Sec. 7 Lot 1 looking NW) in Hyde County, SD in 1984. It...

  4. Polygons Representing Sensitivity of Ground Water to Contamination in Lawrence County, SD

    U.S. Geological Survey, Department of the Interior — This data set includes 956 polygons labeled with a sensitivity-unit code that represents the sensitivity of ground water to contamination in Lawrence County, SD....

  5. S.D. Krashen’s Language Acquisition Theory and the Teaching of Business English Reading



    This paper first illustrates S.D. Krashen’s language acquisition theory, especially two of his five hypotheses as well as the guidance of these theories towards the teaching of business English reading for students majored in business English.

  6. Revisiting PSS and service design in the light of the SD-logic

    Costa, Nina; Patrício, Lia; Morelli, Nicola


    Researchers and practitioners have increasingly recognized the importance of offering value propositions to customers that enable value co-creation as discussed in the service dominant logic (SD-logic). SD-logic recognizes customers as active co-creators and posits that products and services...... are only means to an end. Also, different approaches, methods and tools have been developed to design value propositions however they still lack to explicit the SDlogic principles. The design of solutions that provide value-in-use is at the centre of both Product Service System (PSS) approach and service...... design (SD). Whereas PSS focuses on designing required functions and aims at sustainability, embedding a more organizationcentred approach and problem-solving way of thinking; SD adopts a more human-centred perspective for creative enquiry and focuses on the customer experience, orchestrating...

  7. Roles of MgO release from polyethylene glycol 6000-based solid dispersions on microenvironmental pH, enhanced dissolution and reduced gastrointestinal damage of telmisartan.

    Tran, Phuong Ha-Lien; Tran, Thao Truong-Dinh; Lee, Seung Aeon; Nho, Vo Hong; Chi, Sang-Cheol; Lee, Beom-Jin


    The roles of magnesium oxide (MgO) release from solid dispersions (SDs) in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and water were investigated to elucidate the enhanced dissolution and reduced intestinal damages of telmisartan as a model drug. The polyethylene glycol 6000 (PEG 6000) was used to prepare the SDs. Three SDs were prepared: SD1 (PEG, MgO, TEL), SD2 (PEG 6000, TEL), SD3 (MgO, TEL). The physical mixture (PM) consisting of SD2 and MgO was also prepared. A binary SD without MgO (SD2) was also prepared for comparison in microenvironmental pH (pH(M)) modulation. The faster MgO released, the less control of pH(M) and the less enhanced dissolution of TEL were in consequences. SD3 increased dissolution in SIF and water (about 67%). Interestingly, ternary SD1 showed almost complete dissolution in all three media but dissolution of PM was the lowest due to the fast release of MgO and poor modulation of pH(M). MgO did not change the drug crystallinity but did have a strong molecular interaction with the drug. Additionally, the SD3-bearing tablet quickly increased pH(M) but then gradually decreased due to faster release of MgO while the SD1-bearing tablet gradually increased pH(M) at all fractional dimensions of the tablet by the MgO slowly released. The pH(M) of PM-bearing tablets was not varied as a function of time. Thus, the MgO-bearing SD1 also minimized gastrointestinal tissue damage caused by the model drug.

  8. SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom.

    Ruiming Zhao

    Full Text Available BACKGROUND: Kunitz-type venom peptides have been isolated from a wide variety of venomous animals. They usually have protease inhibitory activity or potassium channel blocking activity, which by virtue of the effects on predator animals are essential for the survival of venomous animals. However, no Kunitz-type peptides from scorpion venom have been functionally characterized. PRINCIPAL FINDINGS: A new Kunitz-type venom peptide gene precursor, SdPI, was cloned and characterized from a venom gland cDNA library of the scorpion Lychas mucronatus. It codes for a signal peptide of 21 residues and a mature peptide of 59 residues. The mature SdPI peptide possesses a unique cysteine framework reticulated by three disulfide bridges, different from all reported Kunitz-type proteins. The recombinant SdPI peptide was functionally expressed. It showed trypsin inhibitory activity with high potency (K(i = 1.6×10(-7 M and thermostability. CONCLUSIONS: The results illustrated that SdPI is a potent and stable serine protease inhibitor. Further mutagenesis and molecular dynamics simulation revealed that SdPI possesses a serine protease inhibitory active site similar to other Kunitz-type venom peptides. To our knowledge, SdPI is the first functionally characterized Kunitz-type trypsin inhibitor derived from scorpion venom, and it represents a new class of Kunitz-type venom peptides.

  9. G eobacter sp. SD-1 with enhanced electrochemical activity in high-salt concentration solutions

    Sun, Dan


    © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd. Summary: An isolate, designated strain SD-1, was obtained from a biofilm dominated by Geobacter sulfurreducens in a microbial fuel cell. The electrochemical activity of strain SD-1 was compared with type strains, G.sulfurreducensPCA and Geobacter metallireducensGS-15, and a mixed culture in microbial electrolysis cells. SD-1 produced a maximum current density of 290±29Am-3 in a high-concentration phosphate buffer solution (PBS-H, 200mM). This current density was significantly higher than that produced by the mixed culture (189±44Am-3) or the type strains (<70Am-3). In a highly saline water (SW; 50mM PBS and 650mM NaCl), current by SD-1 (158±4Am-3) was reduced by 28% compared with 50mM PBS (220±4Am-3), but it was still higher than that of the mixed culture (147±19Am-3), and strains PCA and GS-15 did not produce any current. Electrochemical tests showed that the improved performance of SD-1 was due to its lower charge transfer resistance and more negative potentials produced at higher current densities. These results show that the electrochemical activity of SD-1 was significantly different than other Geobacter strains and mixed cultures in terms of its salt tolerance.

  10. A Mission Planning Algorithm of the Lunar Rover Based on SD * Lite%基于SD*lite的月球车任务规划算法

    董少洋; 居鹤华


    Lunar rover mission planning is a method to plan a lunar rover optimal path considering the initial position and target position and also the constraints of surface topography, mobility constraints, communication constraints, work mode constraints and energy constraints. This paper designs a lunar rover mission planning model and proposes an algorithm planner based on SD * lite, which includes the effect of the limited available resources. It can help the lunar rover get the goal following a reasonable path under the constraint of solar panels energy.%月球车任务规划是在给定初始位置和目标位置,满足月面地形约束、工作模式约束以及能量约束的前提下,规划出月球车最优的路径.设计了一种月球车任务规划的模型,提出了一种基于SD* lite算法的规划器,在原有SD* lite算法的基础上进一步考虑了对可用资源的限制;它可以协胁月球车在考虑太阳能帆板的能量约束的条件下,合理避障最终达到目标点,使规划的轨迹更符合实际.

  11. Dietary Supplementation of Magnesium Oxide (MgO) Nanoparticles for Better Survival and Growth of the Freshwater Prawn Macrobrachium rosenbergii Post-larvae.

    Srinivasan, Veeran; Bhavan, Periyakali Saravana; Rajkumar, Gopalan; Satgurunathan, Thangavelu; Muralisankar, Thirunavukkarasu


    This study was performed to assess the growth-promoting potential of dietary magnesium oxide nanoparticles (MgO NPs) in Macrobrachium rosenbergii post-larvae (PL). MgO NPs were supplemented at 0, 100, 200, 300, 400 and 500 mg kg(-1) with the basal diet (containing 0.95 g Mg kg(-1)); the concentrations of Mg in MgO NP-supplemented diets were increased correspondingly (1.07, 1.15, 1.24, 1.37 and 1.46 g Mg kg(-1) respectively). MgO NP-supplemented diets were fed to M. rosenbergii PL (initial weight 0.11 ± 0.04 g) for a period of 90 days. In the carcasses of experimental prawns, the content of Mg was found to be elevated significantly with respect to the individual diet (102.14, 183.29, 205.46, 221.03, 237.10 and 254.36 μg Mg g(-1) respectively) when compared with that of the control. The contents of Cu, Zn, Fe, Ca, Na and K levels were also found to be elevated in the carcasses of experimental prawns. Significant (P MgO NP-supplemented-feed-fed PL. There were no significant elevations recorded in activities of antioxidant enzymes [superoxide dismutase (SOD) and catalase (CAT)], lipid peroxidation (LPO) and metabolic enzymes [glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT)] recorded in any of the MgO NP-supplemented-feed-fed PL when compared with the control. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) showed increases in the staining intensity of polypeptide bands resolved in 500 mg kg(-1) MgO NP-supplemented-feed-fed PL when compared with the control. Based on the gradual improvement in attaining survival, growth, FCR, biochemical constituents and haemocyte population, this study recommends MgO NP supplementation of 500 mg kg(-1) for sustainable maintenance of M. rosenbergii PL. As the studied highest concentration of MgO NPs showed the best performance, it is necessary to study with beyond 500 mg kg(-1) of MgO NPs to optimize the actual concentration.

  12. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    Riesselmann, A.; Baron, A.; Fregly, M.J. (Univ. of Florida, Gainesville (United States))


    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  13. [The effect of the mutant genes Ta, Ra and Sd on early embryogenesis in mice].

    Sakharova, N Iu; Malashenko, A M; Mezhevikina, L M; Lepikhov, K A; Fialkovskaia, L A


    We studied early embryonic mortality of mice from mutant stocks Tabby (Ta, X-chromosome) and RaSd (RaSd/++, chromosome 2) maintained in the heterozygous state in F1 CBA x C57B1/6 hybrid. Tabby and RaSd mice were reciprocally crossed with F1 mice and examined for the morphological status of embryos washed from the oviduct on the third day of pregnancy, when the stage of eight blastomeres is normally attained. Mortality was evaluated from the number of embryos which did not reach the expected stage by this time. The results have shown that 2-4 cell embryos, which have received gene Ta with the X-chromosome of the female parent, differed from embryos with F1 genotype at the same stage of development by their increased mortality rate, whereas among embryos obtained from RaSd, the mortality was mainly observed before cleavage. Death of embryos receiving the mutant gene from hemizygous Ta males or heterozygous RaSd/++ males was not significantly different from the mortality of embryos without these mutations.

  14. Identification of anterior chamber angle parameters with a portable SD-OCT device compared to a non-portable SD-OCT.

    Akil, Handan; Marion, Kenneth; Dastiridou, Anna; Jenkins, Dennis; Kramer, Brendan; Francis, Brian A; Chopra, Vikas


    The aim of this study is to compare a portable spectral domain optical coherence tomography (SD-OCT) device with a non-portable SD-OCT for the identification of anterior chamber angle parameters based on location of Schwalbe's line (SL) and to measure their reproducibility. 99 eyes from 46 normal, healthy participants underwent imaging of the inferior iridocorneal angle with the iVue and Cirrus SD-OCT under well-controlled low-light conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) were measured by masked, certified graders at the Doheny Image Reading Center using customized Image J grading software. Inter- and intrainstrument, as well as inter- and intraobserver reproducibility of SL-AOD and SL-TISA measurements were evaluated with intraclass correlation coefficients (ICCs) and Bland-Altman plots with limits of agreement. The mean SL-AOD was 0.814 ± 0.315 mm with the iVue and 0.797 ± 0.294 mm with the Cirrus. The mean SL-TISA was 0.247 ± 0.112 mm(2) with iVue and 0.259 ± 0.113 mm(2) with Cirrus. Interinstrument correlation coefficients (r) were 0.93 (P devices. The agreement for intrainstrument (ICCs > 0.95), intragrader (ICCs > 0.93), and intergrader (ICCs > 0.96) was excellent. Excellent agreement between the two devices was also documented with Bland-Altman analysis. Both instruments provide consistent and reproducible measurements of anterior chamber angle metrics.

  15. Brief Introduction of Solar Decathlon(SD)%“太阳能十项全能”竞赛(SD)简述

    李苑; 宋晔皓


    1竞赛概况“太阳能十项全能竞赛”(Solar Decathlon,以下简称SD)是面对全球高校的住宅建筑与可再生能源科技竞赛,由美国能源部于2001年发起并首次主办,两年一届,旨在探索面向21世纪的太阳能建筑,推动建筑、节能与新技术的结合.

  16. Spectroscopic twin to the hypervelocity sdO star US 708 and three fast sdB stars from the Hyper-MUCHFUSS project

    Ziegerer, E.; Heber, U.; Geier, S.; Irrgang, A.; Kupfer, T.; Fürst, F.; Schaffenroth, J.


    Important tracers for the dark matter halo of the Galaxy are hypervelocity stars (HVSs), which are faster than the local escape velocity of the Galaxy and their slower counterparts, the high-velocity stars in the Galactic halo. Such HVSs are believed to be ejected from the Galactic centre (GC) through tidal disruption of a binary by the super-massive black hole (Hills mechanism). The Hyper-MUCHFUSS survey aims at finding high-velocity potentially unbound hot subdwarf stars. We present the spectroscopic and kinematical analyses of a He-sdO as well as three candidates among the sdB stars using optical Keck/ESI and VLT (X-shooter, FORS) spectroscopy. Proper motions are determined by combining positions from early-epoch photographic plates with those derived from modern digital sky surveys. The Galactic rest frame velocities range from 203 km s-1 to 660 km s-1, indicating that most likely all four stars are gravitationally bound to the Galaxy. With Teff = 47 000 K and a surface gravity of log g = 5.7, SDSS J205030.39-061957.8 (J2050) is a spectroscopic twin of the hypervelocity He-sdO US 708. As for the latter, the GC is excluded as a place of origin based on the kinematic analysis. Hence, the Hills mechanism can be excluded for J2050. The ejection velocity is much more moderate (385 ± 79 km s-1) than that of US 708 (998 ± 68 km s-1). The binary thermonuclear supernova scenario suggested for US 708 would explain the observed properties of J2050 very well without pushing the model parameters to their extreme limits, as required for US 708. Accordingly, the star would be the surviving donor of a type Ia supernova. Three sdB stars also showed extreme kinematics; one could be a HVS ejected from the GC, whereas the other two could be ejected from the Galactic disk through the binary supernova mechanism. Alternatively, they might be extreme halo stars.


    Aan Sofyan


    Full Text Available Penelitian ini bertujuan untuk mengetahui perbedaan harapan orang tua siswa yang menyekolahkan anaknya di SDSN dan SD Eks RSBI. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian komparasi. Populasi penelitian adalah orang tua siswa kelas I SDSN dan SD eks RSBI di Daerah Istimewa Yogyakarta (DIY. Sampel 322 orang tua siswa SDSN dan 226 orang tua siswa SD eks RSBI ditentukan dengan cluster random sampling technique. Instrumen penelitian yang digunakan berupa kuesioner harapan orang tua siswa. Instrumen penelitian dikembangkan berdasarkan enam kategori fungsi sekolah yaitu: (1 fungsi mengembangkan kecerdasan pikiran dan memberikan pengetahuan, (2 fungsi spesialisasi, (3 fungsi efisiensi, (4 fungsi sosialisasi, (5 fungsi konservasi, dan (6 fungsi transisi. Pengumpulan data menggunakan skala. Data dianalisis menggunakan statistik non-parametric, dengan menggunakan uji Mann-Whitney. Berdasarkan hasil penelitian yang diperoleh dapat disimpulkan bahwa tidak terdapat perbedaan antara harapan orang tua siswa SDSN dan SD eks RSBI di DIY. Hasil analisis uji Mann-Whitney menunjukkan nilai signifikansi 0,666 yang berarti bahwa hipotesis Ho diterima. Artinya, harapan orang tua siswa SDSN dan SD eks RSBI mengenai fungsi sekolah di DIY adalah sama. Secara keseluruhan baik orang tua siswa SDSN maupun orang tua siswa SD eks RSBI mengharapkan sekolah yang mereka pilih untuk anaknya bisa melaksanakan fungsinya dengan baik.   __________________________________________________________________________________________________________________________________ A COMPARATIVE STUDY ON THE EXPECTATION OF THE PARENTS OF STUDENTS OF SDSN AND EX-RSBI SD IN YOGYAKARTA SPECIAL TERRITORY ABSTRACT This study aimed to determine the differences in the expectations of parents who send their children to SDSN and SD Ex RSBI. This study uses the quantitative approach to the type of compa-rative research. The study population was parents of the students of

  18. Geobacter sp. SD-1 with enhanced electrochemical activity in high-salt concentration solutions.

    Sun, Dan; Call, Douglas; Wang, Aijie; Cheng, Shaoan; Logan, Bruce E


    An isolate, designated strain SD-1, was obtained from a biofilm dominated by Geobacter sulfurreducens in a microbial fuel cell. The electrochemical activity of strain SD-1 was compared with type strains, G. sulfurreducens PCA and Geobacter metallireducens GS-15, and a mixed culture in microbial electrolysis cells. SD-1 produced a maximum current density of 290 ± 29 A m−3 in a high-concentration phosphate buffer solution (PBS-H, 200 mM). This current density was significantly higher than that produced by the mixed culture (189 ± 44 A m−3) or the type strains (Geobacter strains and mixed cultures in terms of its salt tolerance.

  19. Initial results from the Solar Dynamic (SD) Ground Test Demonstration (GTD) project at NASA Lewis

    Shaltens, Richard K.; Boyle, Robert V.


    A government/industry team designed, built, and tested a 2 kWe solar dynamic space power system in a large thermal/vacuum facility with a simulated sun at the NASA Lewis Research Center. The Lewis facility provides an accurate simulation of temperatures, high vacuum, and solar flux as encountered in low earth orbit. This paper reviews the goals and status of the Solar Dynamic (SD) Ground Test Demonstration (GTD) program and describes the initial testing, including both operational and performance data. This SD technology has the potential as a future power source for the International Space Station Alpha.

  20. Temperature and angular momentum dependence of the quadrupole deformation in sd-shell

    P A Ganai; J A Sheikh; I Maqbool; R P Singh


    Temperature and angular momentum dependence of the quadrupole deformation is studied in the middle of the sd-shell for 28Si and 27Si isotopes using the spherical shell model approach. The shell model calculations have been performed using the standard universal sd-shell (USD) interaction and the canonical partition function constructed from the calculated eigensolutions. It is shown that the extracted average quadrupole moments show a transitional behaviour as a function of temperature and the infered transitional temperature is shown to vary with angular momentum. The quadrupole deformation of the individual eigenstate is also analysed.

  1. From novel mathematics to efficient algorithms. Do we have proper SD foundation to build future?

    Tkachov, Fyodor V. [INR RAS, Moscow (Russian Federation)


    Computer implementation of sophisticated algorithms for physics applications is greatly facilitated by the new generation of component-oriented SD technologies pioneered by Wirth's Oberon and embraced by the software industry (Sun's Java and Microsoft's C no.). In a stark contrast with the deeply flawed C++, the Oberon technologies (specifically, the Component Pascal and the BlackBox development environment) offer an unparalleled SD platform for building scientific applications from sophisticated data processing to demanding symbolic calculations. Specific examples are discussed. (author)

  2. The structure of 26Mg investigated with the (d, p) reaction

    Arciszewski, H.F.R.; Bakkum, E.A.; Engelen, C.P.M. van; Endt, P.M.; Kamermans, R.


    Angular distributions have been measured for the 25Mg(d, p)26Mg reaction at 13 MeV leading to excited states between Ex = 0 and 8 MeV. Experimental cross sections are compared with DWBA calculations and extended shell-model calculations in the full sd shell. Spin and parity restrictions are obtained

  3. Detection of Rsp and Modifier Variation in the Meiotic Drive System SEGREGATION DISTORTER (SD) of DROSOPHILA MELANOGASTER

    Lyttle, Terrence W.; Brittnacher, John G.; Ganetzky, Barry


    Identification of allelic variability at the two major loci ( Sd and Rsp) that interact to cause sperm dysfunction in Segregation distorter (SD) males of D. melanogaster has been hampered by the difficulty in separating the elements recombinationally. In addition, small differences in the strength of Sd alleles or sensitivities of Rsp alleles to Sd are difficult to measure against background genetic or environmental variation. Viability effects of the markers used to score progeny classes ma...

  4. Studies of some cancer markers and blood factors in DMBA- induced breast cancer in SD rat strains

    Ahmad Hamta


    Full Text Available Background: Animal suitable models are very useful tools in the studies of complicated diseases. In this way we can study the heterogeneity of human genome and also we can minimize the effect of environmental factors in the incidence of cancers. In this study the expression of VWF and PCNA in tumors was determined by immunohistochemistry and also we measured three cancer markers and two blood factors from affected rats.Methods: We have gavaged 10 mg DMBA dissolved in 0.5 ml sesame oil to the DMBA-treated SD rat strains. After tumor were appeared tumors were used for immunohistochemistry tests. Also we measured three cancer markers and two blood factors according to the manufacturer's protocol and results were analyzed by SPSS software.Results: Interaction of two antibodies PCNA and VWF with their antigen were more robust in tumors samples compared to controls with control samples. From blood factors only in tumors CA13.5 showed significant expression (p<0.05.Conclusion: Histopathology and immunohistochemistry results showed that breast cancer by induced DMBA in rats were similar to human breast cancer. The level of CA15.3 in induced tumors showed significantly increase compared to control blood samples, which is similar to behavior of this cancer marker in human breast cancer. But there was no significant association between treated and control samples related to the other four cancer markers and blood factors These results emphasized that DMBA-induced breast cancer in SD rat strains is a suitable model for biological studies on breast cancers.

  5. Kinetics absorption characteristics of ferrous glycinate in SD rats and its impact on the relevant transport protein.

    Zhuo, Zhao; Fang, Shenglin; Yue, Min; Zhang, Yiwei; Feng, Jie


    Ferrous glycinate (Fe-Gly) maintains high bioavailability in animals, but its exact absorption mechanism is still unknown. Here, we studied on the absorption kinetics of ferrous glycinate and its impact on the relevant transport protein in Sprague-Dawley (SD) rats. A total of 72 SD rats (male, BW 100 ± 6.25 g) were randomly allotted to three treatments. These treatments were perfused with 1 mL of normal saline, ferrous sulfate (FeSO4), and ferrous glycinate (71.35 mg/L as iron) separately. Four rats were selected from each treatment for collection of blood from the tails at certain times (15, 30, 45, 60, 75, 90, 120, 240, and 360 min) after gavage. Moreover, other six rats selected from each treatment were slaughtered for sampling after gavage at 2, 4, and 6 h to evaluate the expression of intestinal transport protein. Pharmacokinetic parameters of iron were determined by one-compartmental analysis. Compared with FeSO4, the peak plasma concentration of iron (C max) is higher in the rats given gavage with Fe-Gly (P < 0.05). Four hours after gavage with Fe-Gly, the expression of divalent metal transporter 1 (DMT1) in the duodenum is significantly decreased (P < 0.05), but the expression of ferroportin 1 (Fpn1) is significantly increased (P < 0.05). This study indicates that Fe-Gly as iron sources can be absorbed more and utilized faster than FeSO4, and they had different effects on the expression of intestinal transport protein.

  6. Effects of Onion (Allium cepa L. Extract Administration on Intestinal α-Glucosidases Activities and Spikes in Postprandial Blood Glucose Levels in SD Rats Model

    Sun-Ho Kim


    Full Text Available Diets high in calories and sweetened foods with disaccharides frequently lead to exaggerated postprandial spikes in blood glucose. This state induces immediate oxidant stress and free radicals which trigger oxidative stress-linked diabetic complications. One of the therapeutic approaches for decreasing postprandial hyperglycemia is to retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes,α-amylase and α-glucosidases, in the digestive organs. Therefore, the inhibitory activity of Korean onion (Allium cepa L. extract against rat intestinal α-glucosidases, such as sucrase, maltase, and porcine pancreatic α-amylase were investigated in vitro and in vivo. The content of quercetin in ethyl alcohol extract of onion skin (EOS was 6.04 g/100 g dried weight of onion skin. The in vitro half-maximal inhibitory concentrations (IC50 of EOS and quercetin, a major phenolic in onion, on rat intestinal sucrase were 0.40 and 0.11 mg/mL, respectively. The postprandial blood glucose lowering effects of EOS and quercetin were compared to a known type 2 diabetes drug (Acarbose, a strong α-glucosidase inhibitor in the Sprague-Dawley (SD rat model. In rats fed on sucrose, EOS significantly reduced the blood glucose spike after sucrose loading. The area under the blood glucose-time curve (AUClast in EOS-treated SD rats (0.5 g-EOS/kg was significantly lower than in untreated SD rats (259.6 ± 5.1 vs. 283.1 ± 19.2 h·mg/dL. The AUClast in quercetin-treated SD rats (0.5 g-quercetin/kg was similar to in EOS-treated group (256.1 ± 3.2 vs. 259.6 ± 5.1 h·mg/dL. Results from this study indicates that although quercetin does have blood glucose lowering potential via α-glucosidase inhibition, there are other bioactive compounds present in onion skin. Furthermore, the effects of two weeks administration of EOS in a high carbohydrate-dietary mixture (Pico 5053 on sucrase and maltase activities in intestine were evaluated in SD rat model

  7. GPU-SD and DPD Parallelization for Gromacs tools for molecular dynamics simulations

    Goga, Nicolae; Marrink, Siewert; Cioromela, Ruxandra; Moldoveanu, Florica


    This article presents the GPU parallelization of new algorithms SD and DPD types for molecular dynamics systems developed by the Molecular Dynamics Group, University of Groningen, the Netherlands. One should note that molecular dynamics simulations are time-consuming simulations of systems, running

  8. Pelaksanaan Pendidikan Agama Pada SD-LB B Sidakarya Kota Denpasar

    Mulyani Mudis Taruna


    Full Text Available The  Research  on the Implementation of Religious Education was conductedat the  SD Luar Biasa Part  B (SD-LB B Sidakarya Denpasar, Bali  Province. Theresults of this study indicate that the religious education implementation at theSD-LB B Sidakarya is still less attention. It can be seen from  the teaching materials that still use the public school textbook and there is no RPP or specialized reference books for SD-LB B, religious teachers concerns to a religion teacher. The supporting factors in the process of learning  is  good  spirit for student availability of classrooms, school infrastructure and the location is not far from the student  environment.  The problem Inhibiting in the  learning    rocess is the lack of teaching tools, no specific reference books for  deaf and dumb there isnt good attantion for religioous teaching is still not getting  the attention of the series.

  9. 78 FR 24228 - Lake Andes National Wildlife Refuge Complex, Lake Andes, SD; Final Comprehensive Conservation Plan


    ... Fish and Wildlife Service Lake Andes National Wildlife Refuge Complex, Lake Andes, SD; Final Comprehensive Conservation Plan AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability... conservation plan and finding of no significant impact (FONSI) for the Lake Andes National Wildlife...


    Eko Pramono


    Full Text Available Penelitian ini bertujuan mengetahui: (1 seberapa besar tingkat implementasi TQM, (2 perbandingan implementasi, (3 aspek-aspek yang perlu mendapatkan perbaikan untuk ditingkatkan. Penelitian evaluasi dengan model descrepancy. Instrumen pengumpul data berupa angket jawaban skala 2 terdiri atas 69 butir. Teknik analisis data menggunakan teknik persentase. Hasil penelitian menunjukkan bahwa: (1 implementasi TQM di SD Negeri Karangrejek II rata-rata sebesar 87,73%, aspek-aspek yang mendekati standar: mutu pembelajaran, organisasi terbalik, perubahan kultur, kolega sebagai pelanggan, profesionalisme, dan pemasaran internal. Implementasi TQM di SD Muhammadiyah Al Mujahidin rata-rata sebesar 94,42%. Aspek-aspek yang mendekati standar: organisasi terbalik, mutu pembelajaran, perubahan kultur, profesionalisme, kaizen dan menjaga hubungan dengan pelanggan. (2 Perbandingan implementasi TQM sebagai berikut: aspek mutu pembelajaran, organisasi terbalik dan perubahan kultur merupakan aspek dengan rata-rata tertinggi di SD Karangrejek II, sedangkan di SD Muhammadiyah Al Mujahidin: aspek organisasi terbalik, mutu pembelajaran, dan perubahan kultur. (3 Aspek yang perlu mendapatkan perbaikan di kedua sekolah adalah perbaikan terus-menerus.

  11. Validity of automated choroidal segmentation in SS-OCT and SD-OCT

    L. Zhang (Li); G.H.S. Buitendijk (Gabrielle); K. Lee (Kyungmoo); M. Sonka (Milan); H. Springelkamp (Henriët); A. Hofman (Albert); J.R. Vingerling (Hans); R.F. Mullins (Robert F.); C.C.W. Klaver (Caroline); M.D. Abràmoff (Michael)


    textabstractPURPOSE. To evaluate the validity of a novel fully automated three-dimensional (3D) method capable of segmenting the choroid from two different optical coherence tomography scanners: swept-source OCT (SS-OCT) and spectral-domain OCT (SD-OCT). METHODS. One hundred eight subjects were

  12. 76 FR 2413 - Notice of Realty Action: Direct Sale of Public Land in Lawrence County, SD


    ... Bureau of Land Management Notice of Realty Action: Direct Sale of Public Land in Lawrence County, SD... public land is being proposed for direct sale to Keith Sauls in accordance with Sections 203 and 209 of... proposing a direct sale to the homeowner, in accordance with 43 CFR ] 2711.3-3, to resolve...

  13. Persepsi Guru dan Siswa SD di Yogyakarta terhadap Program Conservation Scout

    Wahyu Wido Sari


    Full Text Available Penanaman karakter cinta lingkungan dan pemahaman akan pentingnya konservasi perlu dilakukan sejak dini. Program conservation scout atau pandu konservasi menawarkan edukasi dan empowering siswa SD mengenai konservasi. Kegiatan ini bertempat di Pusat Studi Lingkungan, Universitas Sanata Dharma dan melibatkan 38 SD di Yogyakarta. Peserta conservation scout terdiri dari 32 guru dan 70 siswa SD.Penelitian ini bertujuan untuk melihat respon sekolah, persepsi guru, persepsi siswa, dan keberhasilan sekolah dalam mendukung program conservation scout. Metode yang digunakan adalah action reseach, survey, dan diskriptif kualitatif. Instrumen yang digunakan adalah kuesioner dengan hasil validasi sangat baik.Sekolah memberikan respon sangat positif (84% terhadap program conservation scout, dari 38 sekolah yang diundang, ada 32 sekolah yang mengikuti program ini. Guru memberikan persepsi negatif (2,50, bukan pada esensi program melainkan pada teknik pelaksanaan program. Siswa memberikan persepsi positif (3,51 dan 36 dari 70 siswa berhasil melakukan peer tutoring dan kampanye mengenai konservasi. Ada 53, 12 % SD yang siswanya menjadi duta konservasi lingkungan.

  14. Canister storage building compliance assessment SNF project NRC equivalency criteria - HNF-SD-SNF-DB-003

    BLACK, D.M.


    This document presents the Project's position on compliance with the SNF Project NRC Equivalency Criteria--HNF-SD-SNF-DE-003, Spent Nuclear Fuel Project Path Forward Additional NRC Requirements. No non-compliances are shown The compliance statements have been reviewed and approved by DOE. Open items are scheduled to be closed prior to project completion.

  15. Semi-automatic geographic atrophy segmentation for SD-OCT images.

    Chen, Qiang; de Sisternes, Luis; Leng, Theodore; Zheng, Luoluo; Kutzscher, Lauren; Rubin, Daniel L


    Geographic atrophy (GA) is a condition that is associated with retinal thinning and loss of the retinal pigment epithelium (RPE) layer. It appears in advanced stages of non-exudative age-related macular degeneration (AMD) and can lead to vision loss. We present a semi-automated GA segmentation algorithm for spectral-domain optical coherence tomography (SD-OCT) images. The method first identifies and segments a surface between the RPE and the choroid to generate retinal projection images in which the projection region is restricted to a sub-volume of the retina where the presence of GA can be identified. Subsequently, a geometric active contour model is employed to automatically detect and segment the extent of GA in the projection images. Two image data sets, consisting on 55 SD-OCT scans from twelve eyes in eight patients with GA and 56 SD-OCT scans from 56 eyes in 56 patients with GA, respectively, were utilized to qualitatively and quantitatively evaluate the proposed GA segmentation method. Experimental results suggest that the proposed algorithm can achieve high segmentation accuracy. The mean GA overlap ratios between our proposed method and outlines drawn in the SD-OCT scans, our method and outlines drawn in the fundus auto-fluorescence (FAF) images, and the commercial software (Carl Zeiss Meditec proprietary software, Cirrus version 6.0) and outlines drawn in FAF images were 72.60%, 65.88% and 59.83%, respectively.

  16. Low-mass stellar and substellar companions to sdB stars

    Geier, S; Bruenner, P; Nagel, K; Schaffenroth, V; Heuser, C; Heber, U; Drechsel, H; Edelmann, H; Koen, C; O'Toole, S J; Morales-Rueda, L


    It has been suggested that besides stellar companions, substellar objects in close orbits may be able to trigger mass loss in a common envelope phase and form hot subdwarfs. In an ongoing project we search for close substellar companions combining time resolved high resolution spectroscopy with photometry. We determine the fraction of as yet undetected radial velocity variable systems from a sample of 27 apparently single sdB stars to be 16%. We discovered low-mass stellar companions to the He-sdB CPD-20 1123 and the pulsator KPD 0629-0016. The brown dwarf reported to orbit the eclipsing binary SDSS J0820+0008 could be confirmed by an analysis of high resolution spectra taken with UVES. Reflection effects have been detected in the light curves of the known sdB binaries CPD-64 481 and BPS CS 22169-0001. The inclinations of these systems must be much higher than expected and the most likely companion masses are in the substellar regime. Finally, we determined the orbit of the sdB binary PHL 457, which has a ver...

  17. Pemberdayaan Guru dalam Pembelajaran Matematika untuk Meningkatkan Kemampuan Berpikir Kreatif Siswa SD

    Tatag Yuli Eko Siswono


    Full Text Available Abstract: Empowering Mathematics Teachers to Improve Creative Thinking of Elementary-School Students. This experimental study is intended to develop mathematics teachers’ competences in designing teaching and learning strategies that enhance students’ creative thinking. In addition, the study portrays teachers’ creative thinking as well as their competences in planning and implementing problem-solving and problem-posing teaching models. Utilizing a pre-test post-test single group design, this study involved mathematics teachers of the third, fourth, and sixth grades of two elementary schools. The results suggest that the teachers’ creative thinking is of good level; they are creative enough in solving and posing mathematical problems as reflected in their mean score of 92.6. Their competences in planning and implementinglie in good category. Overall, it can be concluded that the teachers are professionally empowered in develo ping students’ creative thinking. Abstrak: Pemberdayaan Guru dalam Pembelajaran Matematika untuk Meningkatkan Kemampuan Berpikir Kreatif Siswa SD. Implementasi pembelajaran matematika di SD untuk mendorong berpikir kreatif masih lemah. Penelitian ini bertujuan memberdayakan guru-guru SD dalam mengembangkan pembelajaran matematika yang memberi bekal kemampuan berpikir kreatif dan memberikan gambaran kemampuan berpikir kreatif guru dan kemampuannya merencanakan serta mengimplementasikan model pembelajaran pengajuan dan pemecahan masalah matematika. Penelitian eksperimen rancangan pretes postes kelompok tunggal sekaligus deskriptif dilakukan terhadap masing-masing dua guru kelas III, IV, dan V SD di kabupaten Sidoarjo. Hasil penelitian menunjukkan bahwa kemampuan berpikir kreatif guru SD berada pada tingkat lebih dari cukup kreatif, dan hasil rata-rata kemampuannya dalam memecahkan dan membuat soal adalah 92,6. Kemampuan guru dalam melaksanakan pembelajaran termasuk kategori lebih dari “baik”. Disimpulkan bahwa

  18. Test characteristics of two rapid antigen detection tests (SD FK50 and SD FK60 for the diagnosis of malaria in returned travellers

    Van Esbroeck Marjan


    Full Text Available Abstract Background Two malaria rapid diagnostic tests were evaluated in a travel clinic setting: the SD FK50 Malaria Ag Plasmodium falciparum test (a two-band test and the SD FK60 Malaria Ag P. falciparum/Pan test (a three-band test. Methods A panel of stored whole blood samples (n = 452 and n = 614 for FK50 and FK60, respectively from returned travellers was used. The reference method was microscopy with PCR in case of discordant results. Results For both tests, overall sensitivity for the detection of P. falciparum was 93.5%, reaching 97.6% and 100% at parasite densities above 100 and 1,000/μl respectively. Overall sensitivities for Plasmodium vivax, Plasmodium ovale and Plasmodium malariae for the FK60 test were 87.5%, 76.3% and 45.2%, but they reached 92.6% and 90.5% for P. vivax and P. ovale at parasite densities above 500/μl. Specificities were above 95% for all species and both tests when corrected by PCR, with visible histidine-rich protein-2 lines for P. malariae (n = 3 and P. vivax and P. ovale (1 sample each. Line intensities were reproducible and correlated to parasite densities. The FK60 tests provided clues to estimate parasite densities for P. falciparum below or above 1,000/μl. Conclusion Both the FK50 and FK60 performed well for the diagnosis of P. falciparum in the present setting, and the FK60 for the diagnosis of P. vivax and P. ovale at parasite densities > 500/μl. The potential use of the FK60 as a semi-quantitative estimation of parasite density needs to be further explored.

  19. 基于 SD 卡的 DSP 自举模块设计%DSP bootload module based on SD card

    董毅; 朱磊; 任静; 郭力


    Bootload module is an indispensable part in electronic systems based on TMS 320VC54x series DSP processor .In face of the problems that the DSP application occupy more and more storage space and requirements while users need a faster and more convenient way to update DSP program code .An DSP bootload module based on the SD card and LabVIEW is presented .This module consists of MCU module and graphical user interface software .MCU module manages and stores DSP user application code by u-sing znFAT file system and SD card .GUI software is designed for format conversion for the DSP user application code and is able to finish multi-step conversion operations within one click .The size of DSP application code is unrestricted and updating DSP application files on the PC is facilitating .Experiments show that DSP bootload module proposed is feasible .%针对DSP应用程序占用越来越大存储空间的问题以及用户对更新DSP程序代码的迫切需求,本文设计了一种基于SD卡的DSP自举模块。该模块由C8051F340单片机子模块与图形用户界面(GUI)组成。单片机子模块利用SD卡与znFAT文件系统存储并管理DSP用户应用程序代码,GUI软件可一键完成DSP用户应用程序代码的多步格式转换操作。本模块不仅使DSP应用程序代码大小不受限制,并且便于在PC机上更新DSP应用程序文件。

  20. The three shapes of 32Mg

    Poves A.


    Full Text Available The N=20 and N=28 “islands of inversion” are described by large scale shell model calculations which mix configurations with different Nħω or equivalently with different number of particles promoted from the sd-shell to the pf -shell. We pay particular attention to the properties of the states at fix Nħω which turn out to be the real protagonists of the physics at N=20. In particular we study the appearance of spherical, deformed and superdeformed structures in 32Mg at fixed 0p-0h, 2p-2h and 4p-4h configurations. Finally we submit that the islands of deformation at N=20 and N=28 merge in the Magnesium isotopes

  1. High-Temperature CO2 Sorption on Hydrotalcite Having a High Mg/Al Molar Ratio.

    Kim, Suji; Jeon, Sang Goo; Lee, Ki Bong


    Hydrotalcites having a Mg/Al molar ratio between 3 and 30 have been synthesized as promising high-temperature CO2 sorbents. The existence of NaNO3 in the hydrotalcite structure, which originates from excess magnesium nitrate in the precursor, markedly increases CO2 sorption uptake by hydrotalcite up to the record high value of 9.27 mol kg(-1) at 240 °C and 1 atm CO2.




      Muhafidin, This research is motivated by the ability of fifth grade students' reading comprehension is low, evidenced by the students do not understand and comprehend the content of reading, students had difficulty answering questions relating to the content of reading, as well as the average value of students still under KKM. This study aims to determine the effect of learning methods talk think write on the ability of reading comprehension folklore in class V SD Negeri 1 Cidempet of Arahan District of Indramayu Regency. This study was an experimental study. The population in this study were students of class V SD Negeri 1 Cidempet of Arahan District of Indramayu Regency totaling 22 students. The sampling technique used is total sampling where authors set into the sample population. So the study sample used is a fifth grade students of SD Negeri 1 Cidempet of Arahan District of Indramayu Regency totaling 20 students. Data collection techniques used is to write test. Data analysis techniques in this study is the normality test and test hypotheses (z test is used to determine the effect of learning methods talk think write to the reading comprehension of folklore in class V SD Negeri 1 Cidempet of Arahan District of Indramayu Regency. Based on test results using a statistical hypothesis test obtained Z hit (7,458> Z daf (2.35, then thank Hi means that there are significant learning method talk think write to the reading comprehension of folklore in class V SD Negeri 1 Cidempet of Arahan District of Indramayu Regency. The conclusion of this study is the application of learning methods talk think write on the ability of reading comprehension folklore in class V SD Negeri 1 Cidempet of Arahan District of Indramayu Regency. Suggestions in this study is teachers can implement a wide variety of learning methods in the implementation of learning so that students are active in studying and understanding the concepts being taught, and teachers should use teaching methods


    Muhammad Nur Wangid


    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan kesiapan guru Sekolah Dasar (SD dalam menerapkan Kurikulum 2013 khususnya dalam pembelajaran tematik-integratif di Daerah Istimewa Yogyakarta (DIY. Jenis penelitian yang digunakan yaitu penelitian survei. Populasi penelitian adalah guru kelas I dan IV yang terdapat di wilayah DIY. Jumlah sampel yang diambil dalam penelitian ini adalah sebanyak 182 guru SD yang berasal dari 49 SD negeri dan 15 SD swasta yang dijadikan pilot project berdasarkan data dari Kemdikbud DIY. Hasil penelitan menunjukkan bahwa persentase kesiapan guru SD di DIY dalam melaksanakan pembelajaran tematik-integratif pada Kurikulum 2013 sebesar 75,85% (siap, dilihat dari aspek kesiapan yaitu aspek Behavioral Readiness diperoleh persentase sebesar 80% (sangat siap, aspek Emotive-Ettitudinal sebesar 78,39% (sangat siap dan aspek Cognitive Readiness sebesar 71,18% (siap. Sedangkan kesiapan guru SD di setiap kabupaten diperoleh hasil persentase sebagai berikut: Sleman 76,13% (sangat siap, Yogyakarta 78,72% (sangat siap, Bantul 73,16% (siap, Gunungkidul 75,54% (siap, dan Kulon Progo 75,42% (siap. ___________________________________________________________________________________________________________________________________________________________________________________________ THE STUDY ON THE ELEMANTARY SCHOOL TEACHERS READINESS IN IMPLEMENTING THEMATIC-INTEGRATIVE TEACHING AND LEARNING IN CURRICULUM 2013, YOGYAKARTA ABSTRACT This study aims to describe the readiness of elementary school teachers in implementing curriculum 2013, based on thematic-integrative learning in Yogyakarta Province. This is a survey study. The research population were elemantary school teachers of class I and IV in DIY. The research sample consisted of 289 elemantary school teachers from 49 public schools and 15 private elementary schools which used as pilot project based on the data from Kemdikbud. The result shows that the percentage of elementary school

  4. 阿特拉津降解菌SD41的分离鉴定及土壤修复%Experimental Study on Atrazine-degrading Strain SD41:Isolation, Identification and Soil Remediation

    李红梅; 张新建; 李纪顺; 魏艳丽; 陈凯; Bazhanav Dzmitry; 杨合同


    从山东省多年施用阿特拉津的农田土壤中分离到一株阿特拉津降解菌SD41,通过形态学、生理生化特征及16S rRNA序列分析初步鉴定为节杆菌属(Arthrobacter sp.).该菌能以阿特拉津为唯一氮源生长,48h内对1 000 mg/L的阿特拉津(pH 7.0)降解率为94.95%,在16~42℃、pH 7~10、0%~3%盐浓度条件下,对阿特拉津都有较高的降解率,外源性氮源对其降解无影响.该菌含有trzN和atzBC 3个阿特拉津降解基因.敏感作物盆栽试验证明,该菌株处理7d能明显恢复小麦的各项生物量指标,具有很好的土壤修复能力,可为阿特拉津的生物修复提供良好的菌种资源.

  5. Spectral analysis of multi mode pulsating sdB stars II. Feige 48, KPD 2109+4401 and PG 1219+534

    Heber, U; Werner, K


    Three members of the new class of pulsating sdB stars (sdBV or EC 14026 stars) are analysed from Keck HIRES spectra using line blanketed NLTE and LTE model atmospheres. Atmospheric parameters (Teff, log g, He/H), metal abundances and rotational velocities are determined. As is typical for sdB stars, all programme stars are found to be helium deficient, with a He abundance ranging from 1/80 solar for Feige 48 to 1/3 solar for PG 1219+534, probably due to diffusion. Most metals are also depleted. The abundances of C, O, Ne, Mg, Al and Si in the high gravity programme stars KPD 2109+4401 and PG 1219+534 are considerably lower than in the lower gravity stars Feige 48 and PG 1605+072 which could be explained by an equilibrium between gravitational settling and radiative levitation. Surprisingly iron is solar to within error limits in all programme stars irrespective of their gravity, confirming predictions from diffusion calculations. The metal lines are very sharp and allow the microturbulent velocity to be const...

  6. Magnesium isotopic composition of the oceanic mantle and oceanic Mg cycling

    Liu, Ping-Ping; Teng, Fang-Zhen; Dick, Henry J. B.; Zhou, Mei-Fu; Chung, Sun-Lin


    To constrain the Mg isotopic composition of the oceanic mantle, investigate Mg isotope fractionation of abyssal peridotites during seafloor alteration, and assess Mg budget in the oceans, a suite of 32 abyssal peridotite samples from the Gakkel Ridge and Southwest Indian Ridge (SWIR) was, for the first time, selected for high-precision Mg isotope analyses. Although most of these samples are extensively altered, largely by serpentinization and weathering, primary olivine, diopside and enstatite grains are preserved in some samples. Olivine grains from the least altered samples have δ26Mg varying from -0.30 to -0.12‰ (n = 7), whereas enstatite and diopside have δ26Mg varying from -0.27 to -0.16‰ (n = 7), and from -0.23 to -0.09‰ (n = 6), respectively. Whole-rock δ26Mg values range from -0.24 to 0.03‰ with an average of -0.12 ± 0.13‰ (2SD, n = 32). Strongly serpentinized peridotites have lower average δ26Mg values (δ26Mg = -0.19 ± 0.07‰, 2SD, n = 7) than weathering-dominated ones (δ26Mg = -0.10 ± 0.12‰, 2SD, n = 25). Calculated Mg isotopic compositions of fresh mantle peridotites vary from -0.29 to -0.13‰, beyond the previously reported range of the subcontinental lithospheric mantle (-0.25 ± 0.04‰) and the analytical uncertainty (±0.07‰, 2SD). Our study therefore indicates that the oceanic mantle may have similar but slightly heterogeneous Mg isotopic compositions to that of subcontinental lithospheric mantle. Secondary serpentinization does not fractionate Mg isotopes of abyssal peridotites, whereas low-T weathering and formation of clay can result in the enrichment of heavy Mg isotopes in abyssal peridotites. This study also demonstrates that fluid-rock interaction does not necessarily produce rocks with intermediate Mg isotopic compositions. Magnesium isotopes of the rocks thereafter are dependent on the secondary minerals formed. We also conclude that the release of light Mg isotopes into the ocean during alteration of abyssal

  7. Somatoform abdominal pain in surgery: is SD worthy of surgical attention? Case reports and literature review.

    Abd Elwahab, Sami Medani


    Somatoform disorders (SD) or medically unexplained physical symptoms (MUPS) are a group of disorders that represent a group of symptoms that cannot be explained by an organic or physical pathology. These disorders are widely prevalent, and, if unrecognised, SD may lead medical professionals to embark on tests or procedures which may inflict unnecessary iatrogenic complications. Despite the high prevalence, they are only poorly included in medical training curricula, at both undergraduate and postgraduate levels. In this article, we review the literature and present two cases. The first one presented with a recurrent acute abdomen had an unnecessary CT abdomen. The second case had laparoscopy for acute right-sided abdominal pain which turned out to be normal, and was readmitted again after a short period with acute urine retention which resolved spontaneously following discussion with the patient and family. Both cases were referred for psychiatric assessment and their family doctors were informed.

  8. SD-AODV: A Protocol for Secure and Dynamic Data Dissemination in Mobile Ad Hoc Network

    Nath, Rajender


    Security remains as a major concern in the mobile ad hoc networks. This paper presents a new protocol SD-AODV, which is an extension of the exiting protocol AODV. The proposed protocol is made secure and dynamic against three main types of routing attacks- wormhole attack, byzantine attack and blackhole attack. SD-AODV protocol was evaluated through simulation experiments done on Glomosim and performance of the network was measured in terms of packet delivery fraction, average end-to-end delay, global throughput and route errors of a mobile ad hoc network where a defined percentage of nodes behave maliciously. Experimentally it was found that the performance of the network did not degrade in the presence of the above said attacks indicating that the proposed protocol was secure against these attacks.

  9. Optimising SD and LSD in Presence of Non-uniform Probabilities of Revocation

    D'Arco, Paolo; de Santis, Alfredo

    Some years ago two efficient broadcast encryption schemes for stateless receivers, referred to as SD (Subset Difference Method) [NNL01] and LSD (Layered Subset Difference Method) [HS02] , were proposed. They represent one of the most suitable solution to broadcast encryption. In this paper we focus on the following issue: both schemes assume uniform probabilities of revocation of the receivers. However, in some applications, such an assumption might not hold: receivers in a certain area, due to historical and legal reasons, can be considered trustworthy, while receivers from others might exhibit more adversarial behaviours. Can we modify SD and LSD to better fit settings in which the probabilities of revocation are non-uniform?


    Fivi Melva Diana


    Full Text Available Laporan Tahunan Tahun 2011 Dinas kesehatan Kabupaten Karimun, sekolah yang telah melaksanakan PHBS hanya 22,5% dengan target 65% sedangkan target nasional intitusi pendidikan yang melaksanakanPHBS adalah 70% ditahun 2014. Rendahnya cakupan ini berdampak juga terhadap tingginya angka kesakitan yang berhubungan dengan penyakit yang berorientasi lingkungan dan perilaku. Tujuan penelitian adalah mengetahui hubungan sikap, pengetahuan dan peran guru dengan pelaksanaan PHBS di SD negeri 001 Tanjung Balai Karimun Tahun 2013. Desain Crossectional Study, populasi adalah seluruh murid kelas IV, V dan IV, sedangkan sampel sebanyak 64 orang dan dibagi secara proporsionaluntuk masing-masingkelas. Data dikumpulkan melalui kuesioner, diolah dengan uji Chi-square. Darihasil uji statistik terdapat hubunganbermakna antara pengetahuan, dan peran guru dengan pelaksanan program PHBS pada anak sekolah di SD Negeri 001 Tanjung Balai Karimun Tahun 2013 (p>0,05.Disarankan untuk meningkatan pengetahuan melalui pelatihan, penyuluhan dan memperbanyak mediapromosi seperti poster, leaflet dll.

  11. Revisiting PSS and service design in the light of the SD-logic

    Costa, Nina; Patrício, Lia; Morelli, Nicola


    are only means to an end. Also, different approaches, methods and tools have been developed to design value propositions however they still lack to explicit the SDlogic principles. The design of solutions that provide value-in-use is at the centre of both Product Service System (PSS) approach and service...... interactions between different actors that engage over time, in a complex socio-technological environment. Although SD becomes more established as a discipline, it tends to focus on the early stages of the design process and could further expand its impact if integrated with current organizational innovation...... comprehensive discussion about these two approaches and proposes a conceptual framework for integrating PSS organizational point of view; and SD human-centred focus to design better service....




    Full Text Available Problem faced by SD IPEKA Tomang is not reaching its predicted target in English subject. This is caused by less understanding among students in important parts of English which reflected in making sentences or writing essays. Teachers have difficulty in explaining about grammar usage to students, which is the basic knowledge in making sentences. In order to avoid this problem, SD IPEKA Tomang is adding or replacing the teaching media into a computer media. In doing this analysis and designing of e-learning is using ADDIE Model approach. This research is done through stages of analysis, design, and development. Analysis stage uses Gap Analysis approach to understand the needs of e-learning.

  13. SD-AODV: A Protocol for Secure and Dynamic Data Dissemination in Mobile Ad Hoc Network

    Rajender Nath


    Full Text Available Security remains as a major concern in the mobile ad hoc networks. This paper presents a new protocol SD-AODV, which is an extension of the exiting protocol AODV. The proposed protocol is made secure and dynamic against three main types of routing attacks-wormhole attack, byzantine attack and blackhole attack. SD-AODV protocol was evaluated through simulation experiments done on Glomosim and performance of the network was measured in terms of packet delivery fraction, average end-to-end delay, global throughput and route errors of a mobile ad hoc network where a defined percentage of nodes behave maliciously. Experimentally it was found that the performance of the network did not degrade in the presence of the above said attacks indicating that the proposed protocol was secure against these attacks.

  14. SD-REE: A Cryptographic Method to Exclude Repetition from a Message

    Dey, Somdip


    In this paper, the author presents a new cryptographic technique, SD-REE, to exclude the repetitive terms in a message, when it is to be encrypted, so that it becomes almost impossible for a person to retrieve or predict the original message from the encrypted message. In modern world, cryptography hackers try to break a code or cryptographic algorithm [1,2] or retrieve the key, used for encryption, by inserting repetitive bytes / characters in the message and encrypt the message or by analyzing repetitions in the encrypted message, to find out the encryption algorithm or retrieve the key used for the encryption. But in SD-REE method the repetitive bytes / characters are removed and there is no trace of any repetition in the message, which was encrypted.

  15. Spectral analysis of sdB stars from the Hamburg Quasar Survey

    Edelmann, H; Hagen, H J; Lemke, M; Dreizler, S; Napiwotzki, R; Engels, D


    We present the results of a spectral analysis of a large sample of subdwarf B stars selected from follow-up observations of candidates from the Hamburg Quasar Survey. Fundamental parameters (effective temperature, gravity, and helium abundance) were determined by matching synthetic line profiles calculated from model atmospheres to all hydrogen and helium absorption lines present in the observed optical spectra. The derived helium abundances are compared with the atmospheric parameters to search forpossible trends. We discovered a correlation between the helium abundance and the effective temperature: the larger the temperature, the larger the photospheric helium content of sdB stars. Additionally, a separation into two sequences of sdB stars in the effective temperature - helium abundance plane is detected. We compared our analysis results with data from the literature. The stars from our sample are found to be somewhat more luminous. This can only partlybe explained by NLTE effects. Three apparently normal ...


    Khairiyah; Ansar, Jumriani; Dwinata, Indra


    World Health Organization (WHO) melaporkan bahwa pada tahun 2010, tingkat obesitas di dunia telah meningkat lebih dari dua kali lipat sejak 1980. Data Riskesdas tahun 2010 memperlihatkan prevalensi obesitas anak usia sekolah (6-12 tahun) sebesar 9.2%. Penelitian ini bertujuan mengetahui hubungan jenis kelamin, aktivitas fisik,riwayat orang tua dan perilaku jajan dengan kejadian obesitas pada Anak di SD Negeri 7 Salotungo Kecamatan Lalabata Kabupaten Soppeng. Jenis penelitian yang digunakan ad...

  17. Inversion for Eigenvalues and Modes Using Sierra-SD and ROL.

    Walsh, Timothy [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Aquino, Wilkins [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ridzal, Denis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kouri, Drew Philip [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    In this report we formulate eigenvalue-based methods for model calibration using a PDE-constrained optimization framework. We derive the abstract optimization operators from first principles and implement these methods using Sierra-SD and the Rapid Optimization Library (ROL). To demon- strate this approach, we use experimental measurements and an inverse solution to compute the joint and elastic foam properties of a low-fidelity unit (LFU) model.


    Doni Septumarsa Ibrahim


    Full Text Available Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh penggunaan e-learning terhadap motivasi dan prestasi belajar matematika siswa SD Negeri Tahunan Yogyakarta. Populasi penelitian ini adalah siswa SD Negeri Tahunan Yogyakarta dengan sampel siswa kelas IVA dan IVB yang berjumlah 66 siswa. Penelitian ini dilaksanakan dari bulan Mei sampai dengan bulan Juni tahun 2012. Penelitian ini merupakan penelitian quasi eksperimen dengan menggunakan posttest-only control-group design. Statistik analisis uji t digunakan untuk mengetahui perbedaan rerata dua buah kelompok dan uji T2 Hotteling’s Trace untuk mengetahui pengaruh penggunaan e-learning terhadap motivasi dan prestasi belajar siswa. Berdasarkan hasil uji t dapat diketahui motivasi belajar siswa menunjukkan nilai signifikansi sebesar 0,008 atau lebih kecil dari α 5% dan prestasi belajar siswa menunjukkan nilai signifikansi sebesar 0,003 atau lebih kecil dari α 5% yang berarti bahwa: Ada perbedaan motivasi dan prestasi belajar matematika siswa menggunakan e-learning di SD Negeri Tahunan Yogyakarta. Berdasarkan hasil uji T2 Hotteling’s Trace diketahui nilai signifikasi sebesar 0,001 atau lebih kecil dari α 5% dan rata-rata skor angket untuk motivasi belajar siswa kelompok eksperimen sebesar 74,03 dan kelompok kontrol sebesar 70,42 dan rata-rata skor tes untuk prestasi belajar siswa kelompok eksperimen sebesar 15,45 dan kelompok kontrol sebesar 12,09 yang berarti bahwa ada pengaruh positif penggunaan e-learning terhadap motivasi dan prestasi belajar siswa di SD Negeri Tahunan Yogyakarta. Kata kunci : e-learning, motivasi, prestasi

  19. KBS 13 -- a Rare Reflection Effect sdB Binary with an M Dwarf Secondary

    For, B Q; Green, E M; Drechsel, H; Nesslinger, S; Fontaine, G


    We report preliminary VRI differential photometric and spectroscopic results for KBS 13, a recently discovered non-eclipsing sdB+dM system. Radial velocity measurements indicate an orbital period of 0.2923 +/- 0.0004 days with a semi-amplitude velocity of 22.82 +/- 0.23 km s-1. This suggests the smallest secondary minimum mass yet found. We discuss the distribution of orbital periods and secondary minimum masses for other similar systems.

  20. Geology of the USW SD-12 drill hole Yucca Mountain, Nevada

    Rautman, C.A. [Sandia National Labs., Albuquerque, NM (United States); Engstrom, D.A. [Spectra Research Institute, Albuquerque, NM (United States)


    Drill hole USW SD-12 is one of several holes drilled under Site Characterization Plan Study, also known as the {open_quotes}Systematic Drilling Program,{close_quotes} as part of the U.S. Department of Energy characterization program at Yucca Mountain, Nevada, which has been proposed as the potential location of a repository for high-level nuclear waste. The SD-12 drill hole is located in the central part of the potential repository area, immediately to the west of the Main Test Level drift of the Exploratory Studies Facility and slightly south of midway between the North Ramp and planned South Ramp declines. Drill hole USW SD-12 is 2166.3 ft (660.26 m) deep, and the core recovered essentially complete sections of ash-flow tuffs belonging to the lower half of the Tiva Canyon Tuff, the Pah Canyon Tuff, and the Topopah Spring Tuff, all of which are part of the Miocene Paintbrush Group. A virtually complete section of the Calico Hills Formation was also recovered, as was core from the entire Prow Pass Tuff formation of the Crater Flat Group.


    Sofyan Rofi


    Full Text Available Objective of the study : (1 to know how far parents’ role student learning achievement at Al-furqan Jember, (2 how to correlation between parent of student and school at SD Al-Furqan Jember. This study was done at SD Al-Furqan Jember, by using qualitative approach. Data collecting technique was done by : (1 deep interview, (2 documentation. While checking up data validity was done by cross check with triangulation technique and colleagues discussion. Data analysis was done by (1 data reduction, (2 data presentation, (3 withdrawal of conclusion. From data analysis was found that parent has so central to student learning achievement, because education in school is still not enough increase student learning achievement. With the parents’ role so not just teacher wo strive to increase student learning achievement however parent does advising to their child by join the course. While relation between student old fellow with school intertwin intensive communications with meeting of pupil sponsor mothers in majelis ta’lim that conducted by institution of Al-Furqan Jember. From all data and the result of research finding is found that parents’ role is so necessary to student learning achievement of SD Al-Furqan Jember and relation among student old fellow with school is very good and communicative. As for researcher suggestion is school have to be more improve role of old fellow to student learning process, in order to student achievement progressively mount.       Key word : Parent, learning achievement

  2. Automated segmentation of serous pigment epithelium detachment in SD-OCT images

    Sun, Zhuli; Shi, Fei; Xiang, Dehui; Chen, Haoyu; Chen, Xinjian


    Pigment epithelium detachment (PED) is an important clinical manifestation of multiple chorio-retinal disease processes, which can cause the loss of central vision. A 3-D method is proposed to automatically segment serous PED in SD-OCT images. The proposed method consists of five steps: first, a curvature anisotropic diffusion filter is applied to remove speckle noise. Second, the graph search method is applied for abnormal retinal layer segmentation associated with retinal pigment epithelium (RPE) deformation. During this process, Bruch's membrane, which doesn't show in the SD-OCT images, is estimated with the convex hull algorithm. Third, the foreground and background seeds are automatically obtained from retinal layer segmentation result. Fourth, the serous PED is segmented based on the graph cut method. Finally, a post-processing step is applied to remove false positive regions based on mathematical morphology. The proposed method was tested on 20 SD-OCT volumes from 20 patients diagnosed with serous PED. The average true positive volume fraction (TPVF), false positive volume fraction (FPVF), dice similarity coefficient (DSC) and positive predictive value (PPV) are 97.19%, 0.03%, 96.34% and 95.59%, respectively. Linear regression analysis shows a strong correlation (r = 0.975) comparing the segmented PED volumes with the ground truth labeled by an ophthalmology expert. The proposed method can provide clinicians with accurate quantitative information, including shape, size and position of the PED regions, which can assist diagnose and treatment.

  3. Diffractional Imaging of Mantle Transition Zone Discontinuities Using SdS-SS Traveltimes

    Guo, Z.; Zhou, Y.


    The mantle transition zone is characterized by two discontinuities at depths of about 410 and 660 km. Mineral physics studies suggest that wavespeed and density jumps across the discontinuities are associated with olivine phase transformations and the depths at which the phase transformations occur are strongly dependent on temperature. Imaging lateral variations of the discontinuity depths is important for constraining thermal structure in the mid mantle. SS precursors (SdS) are waves reflected at the underside of the discontinuities and arrive beforethe SS phase. Their traveltime measurements at teleseismic distances can be used to map the discontinuities at a global scale. In this study, we measure frequency-dependent SS precursors traveltimes using seismograms recorded at GSN stations for earthquakes occurred between 2000 and 2015. The measurements were made using cosine tapers and multitapers and the traveltimes show significant dispersion. We calculate finite-frequency sensitivity kernels for SdS-SS differential measurements based on traveling-wave mode summation, which account for complete wave interactions within the measurement window. We will discuss preliminary results from finite-frequency imaging using SdS-SS dispersion measurements and the effects of 3-D crustal structure and mantle wavespeed structure.


    Tukiman Tukiman


    Full Text Available Penelitian ini bertujuan untuk mengungkapkan implementasi kepemimpinan transformasional kepala sekolah dalam meningkatkan mutu sekolah SD Kanisius Sengkan, Kabupaten Sleman. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian studi kasus. Pengumpulan data menggunakan metode kajian dokumen, observasi, dan wawancara. Analisis data menggunakan analisis model interaktif dari Miles dan Huberman yang meliputi empat tahap analisis yaitu: pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kepemimpinan transformasional kepala sekolah SD Kanisius Sengkan mampu menciptakan perubahan dan membawa SD Kanisius mencapai prestasi yang baik. Kepala sekolah menjadi tokoh panutan yang dihormati, dihargai, dan dipercaya. Kepala sekolah mampu membangun semangat kebersamaan dan kedisiplinan serta memotivasi para guru dan karyawan untuk bekerja secara optimal. Kepala sekolah berani melakukan perubahan melalui tindakan-tindakan yang kreatif dan inovatif. Akhirnya kepala sekolah mampu membangun kesadaran berorganisasi pada para guru dan karyawan dengan mengembangkan sikap rasa memiliki dan rasa bertanggung jawab untuk meraih prestasi setinggi-tingginya.Kata kunci: kepala sekolah, kepemimpian transformasional, mutu sekolah.

  5. KIC7668647: a 14 day beaming sdB+WD binary with a pulsating subdwarf

    Telting, J H; Nemeth, P; Ostensen, R H; Kupfer, T; Macfarlane, S; Heber, U; Aerts, C; Geier, S


    The recently discovered subdwarf B (sdB) pulsator KIC7668647 is one of the 18 pulsating sdB stars detected in the Kepler field. It features a rich g-mode frequency spectrum, with a few low-amplitude p-modes at short periods. We use new ground-based low-resolution spectroscopy, and the near-continuous 2.88 year Kepler lightcurve, to reveal that KIC7668647 consists of a subdwarf B star with an unseen white-dwarf companion with an orbital period of 14.2d. An orbit with a radial-velocity amplitude of 39km/s is consistently determined from the spectra, from the orbital Doppler beaming seen by Kepler at 163ppm, and from measuring the orbital light-travel delay of 27 by timing of the many pulsations seen in the Kepler lightcurve. The white dwarf has a minimum mass of 0.40 M_sun. We use our high signal-to-noise average spectra to study the atmospheric parameters of the sdB star, and find that nitrogen and iron have abundances close to solar values, while helium, carbon, oxygen and silicon are underabundant relative t...

  6. A new sdO+dM binary with extreme eclipses and reflection effect

    Derekas, A; Southworth, J; Borkovits, T; Sarneczky, K; Pal, A; Csak, B; Garcia-Alvarez, D; Maxted, P F L; Kiss, L L; Vida, K; Szabo, Gy M; Kriskovics, L


    We report the discovery of a new totally-eclipsing binary (RA=06:40:29.11; Dec=+38:56:52.2; J=2000.0; Rmax=17.2 mag) with an sdO primary and a strongly irradiated red dwarf companion. It has an orbital period of Porb=0.187284394(11) d and an optical eclipse depth in excess of 5 magnitudes. We obtained two low-resolution classification spectra with GTC/OSIRIS and ten medium-resolution spectra with WHT/ISIS to constrain the properties of the binary members. The spectra are dominated by H Balmer and He II absorption lines from the sdO star, and phase-dependent emission lines from the irradiated companion. A combined spectroscopic and light curve analysis implies a hot subdwarf temperature of Teff(spec) = 55 000 +/- 3000K, surface gravity of log g(phot) = 6.2 +/- 0.04 (cgs) and a He abundance of log(nHe/nH) = -2.24 +/- 0.40. The hot sdO star irradiates the red-dwarf companion, heating its substellar point to about 22 500K. Surface parameters for the companion are difficult to constrain from the currently availabl...

  7. Importance of prumycin produced by Bacillus amyloliquefaciens SD-32 in biocontrol against cucumber powdery mildew disease.

    Tanaka, Keijitsu; Fukuda, Mutsumi; Amaki, Yusuke; Sakaguchi, Takatoshi; Inai, Koji; Ishihara, Atsushi; Nakajima, Hiromitsu


    Powdery mildew disease of cucurbits is caused mainly by Podosphaera fusca, which is one of the most important limiting factors in cucurbit production worldwide. Previously we reported that Bacillus amyloliquefaciens biocontrol strain SD-32 produces C17 bacillomycin D and [Ile]surfactin, and that these metabolites play important roles in SD-32's biocontrol over cucumber gray mold disease. Our further investigation demonstrated that the culture broth and its supernatant suppressed cucumber powdery mildew disease in greenhouse experiments. However, the active principle(s) remained unknown. The active compound was isolated from the culture supernatant after anti-powdery mildew disease activity-guided purification and identified as prumycin. Prumycin significantly suppressed the disease, whereas bacillomycin D and [Ile]surfactin did not. Prumycin did not induce the expression of plant defense genes (PR1a and VSP1), suggesting that it does not act via plant defense response. Light microscopic observations of prumycin-treated cucumber cotyledon suggested that prumycin inhibits the conidial germination of P. fusca. This study demonstrates that prumycin is a major factor in SD-32's suppression of cucumber powdery mildew disease. Our findings shed light for the first time on prumycin's role in biocontrol by Bacillus against this disease. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.


    Sigit dk


    Full Text Available Kekerasan  yang terjadi di Indonesia dari hari ke sehari angkanya semakin meningkat, kekerasan itu terjadi terhadap perempuan, anak-anak,  dan kekerasan  biasanya  lebih  banyak dalam rumah tangga (KDRT. Data yang dilansir Komnas Perempuan paska diundangkan UU-PKDRT tahun 2004 menunjukkan angka yang sangat memprihatinkan. Oleh karena itu masalah  kekerasan terhadap istri (KTI  tahun 2004 mencapai 1.782 kasus, sedang tahun 2005 terdapat 4.889 kasus, dan tahun 2007  mencapai 17.772 kasus  dan angka tersebut cenderung meningkat (Kedaulatan Rakyat 29 Nov. 2008; 1. Dalam peringatan 16 hari anti kekerasan terhadap perempuan yang dimulai tanggal 25 November 2008 sampai dengan 10 Desember 2008, hari AIDS 1 Desember dan hari Hak Azasi Manusia (HAM  jatuh  pada tanggal 10 Desember masih terdapat kekerasan masif,  dan agaknya bangsa ini perlu meratifikasi kembali pelbagai kekerasan yang terjadi di Indonesia. Kekerasan virtual juga disuguhkan di layar TV melalui film anak-anak seperti Naruto, Avatar dan media elektronika melalui komputer, geme onliene dan tersosialisasi pada anak-anak SD (Sekolah Dasar.  Akibatnya anak-anak SD akrab dengan kekerasan dan mengimplementasikan dalam bentuk perilaku yang distruktif. Melalui Pendidikan anti kekerasan diharapkan dapat memberikan secercah harapan agar generasi muda khususnya anak SD menjadi warga negara yang baik, cinta damai mengasihi sesama mengabdikan diri pada anti kekerasan.   Kata Kunci: Pendididikan, Kekerasan, Sekolah Dasar.

  9. Stripped Red Giants - Helium Core White Dwarf Progenitors and their sdB Siblings

    Heber, U.


    Some gaps in the mosaic of binary star evolution have recently been filled by the discoveries of helium-core white dwarf progenitors (often called extremely low mass (ELM) white dwarfs) as stripped cores of first-giant branch objects. Two varieties can be distinguished. One class is made up by SB1 binaries, companions being white dwarfs as well. Another class, the so-called EL CVn stars, are composite spectrum binaries, with A-Type companions. Pulsating stars are found among both classes. A riddle is posed by the apparently single objects. There is a one-to-one correspondence of the phenomena found for these new classes of star to those observed for sdB stars. In fact, standard evolutionary scenarios explain the origin of sdB stars as red giants that have been stripped close to the tip of first red giant branch. A subgroup of subluminous B stars can also be identified as stripped helium-cores of red giants. They form an extension of the ELM sequence to higher temperatures. Hence low mass white dwarfs of helium cores and sdB stars in binaries are close relatives in terms of stellar evolution.

  10. The mysterious sdO X-ray binary BD+37 442

    Heber, U; Irrgang, A; Schneider, D; Barbu-Barna, I; Mereghetti, S; La Palombara, N


    Pulsed X-ray emission in the luminous, helium-rich sdO BD+37 442 has recently been discovered (La Palombara et al., 2012). It was suggested that the sdO star has a neutron star or white dwarf companion with a spin period of 19.2 s. After HD 49798, which has a massive white dwarf companion spinning at 13.2 s in an 1.55 day orbit, this is only the second O-type subdwarf from which X-ray emission has been detected. We report preliminary results of our ongoing campaign to obtain time-resolved high-resolution spectroscopy using the CAFE instrument at Calar Alto observatory and SARG at the Telescopio Nationale Galileo. Atmospheric parameters were derived via a quantitative NLTE spectral analysis. The line fits hint at an unusually large projected rotation velocity. Therefore it seemed likely that BD+37 442 is a binary similar to HD 49798 and that the orbital period is also similar. The level of X-ray emission from BD+37 442 could be explained by accretion from the sdO wind by a neutron star orbiting at a period of ...

  11. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model

    Hyo-Seon Kim; Hyeong-Geug Kim; Hye-Won Lee; Sung-Bae Lee; Jin-Seok Lee; Hwi-Jin Im; Won-Yong Kim; Dong-Soo Lee; Chang-Gue Son


    We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A. iwayomogi, A. xanthioides, and S. miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis. Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly). Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily. DMN injection caused substantial ...

  12. Geology of the USW SD-7 drill hole Yucca Mountain, Nevada

    Rautman, C.A. [Sandia National Laboratories, Albuquerque, NM (United States); Engstrom, D.A. [Spectra Research Inst., Albuquerque, NM (United States)


    The USW SD-7 drill hole is one of several holes drilled under Site Characterization Plan Study, also known as the Systematic Drilling Program, as part of the U.S. Department of Energy characterization program at Yucca Mountain, Nevada. The Yucca Mountain site has been proposed as the potential location of a repository for high-level nuclear waste. The SD-7 drill hole is located near the southern end of the potential repository area and immediately to the west of the Main Test Level drift of the Exploratory Studies Facility. The hole is not far from the junction of the Main Test Level drift and the proposed South Ramp decline. Drill hole USW SD-7 is 2675.1 ft (815.3 m) deep, and the core recovered nearly complete sections of ash-flow tuffs belonging to the lower half of the Tiva Canyon Tuff, the Pah Canyon Tuff, and the Topopah Spring Tuff, all of which are part of the Miocene Paintbrush Group. Core was recovered from much of the underlying Calico Hills Formation, and core was virtually continuous in the Prow Pass Tuff and the Bullfrog Tuff. The SD-7 drill hole penetrated the top several tens of feet into the Tram Tuff, which underlies the Prow Pass and Bullfrog Tuffs. These latter three units are all formations of the Crater Flat Group, The drill hole was collared in welded materials assigned to the crystal-poor middle nonlithophysal zone of the Tiva Canyon Tuff; approximately 280 ft (85 m) of this ash-flow sheet was penetrated by the hole. The Yucca Mountain Tuff appears to be missing from the section at the USW SD-7 location, and the Pah Canyon Tuff is only 14.5 ft thick. The Pah Canyon Tuff was not recovered in core because of drilling difficulties, suggesting that the unit is entirely nonwelded. The presence of this unit is inferred through interpretation of down-hole geophysical logs.

  13. Geology of the USW SD-7 drill hole Yucca Mountain, Nevada

    Rautman, C.A. [Sandia National Laboratories, Albuquerque, NM (United States); Engstrom, D.A. [Spectra Research Inst., Albuquerque, NM (United States)


    The USW SD-7 drill hole is one of several holes drilled under Site Characterization Plan Study, also known as the Systematic Drilling Program, as part of the U.S. Department of Energy characterization program at Yucca Mountain, Nevada. The Yucca Mountain site has been proposed as the potential location of a repository for high-level nuclear waste. The SD-7 drill hole is located near the southern end of the potential repository area and immediately to the west of the Main Test Level drift of the Exploratory Studies Facility. The hole is not far from the junction of the Main Test Level drift and the proposed South Ramp decline. Drill hole USW SD-7 is 2675.1 ft (815.3 m) deep, and the core recovered nearly complete sections of ash-flow tuffs belonging to the lower half of the Tiva Canyon Tuff, the Pah Canyon Tuff, and the Topopah Spring Tuff, all of which are part of the Miocene Paintbrush Group. Core was recovered from much of the underlying Calico Hills Formation, and core was virtually continuous in the Prow Pass Tuff and the Bullfrog Tuff. The SD-7 drill hole penetrated the top several tens of feet into the Tram Tuff, which underlies the Prow Pass and Bullfrog Tuffs. These latter three units are all formations of the Crater Flat Group, The drill hole was collared in welded materials assigned to the crystal-poor middle nonlithophysal zone of the Tiva Canyon Tuff; approximately 280 ft (85 m) of this ash-flow sheet was penetrated by the hole. The Yucca Mountain Tuff appears to be missing from the section at the USW SD-7 location, and the Pah Canyon Tuff is only 14.5 ft thick. The Pah Canyon Tuff was not recovered in core because of drilling difficulties, suggesting that the unit is entirely nonwelded. The presence of this unit is inferred through interpretation of down-hole geophysical logs.

  14. Detection of Rsp and modifier variation in the meiotic drive system Segregation distorter (SD) of Drosophila melanogaster.

    Lyttle, T W; Brittnacher, J G; Ganetzky, B


    Identification of allelic variability at the two major loci (Sd and Rsp) that interact to cause sperm dysfunction in Segregation distorter (SD) males of D. melanogaster has been hampered by the difficulty in separating the elements recombinationally. In addition, small differences in the strength of Sd alleles or sensitivities of Rsp alleles to Sd are difficult to measure against background genetic or environmental variation. Viability effects of the markers used to score progeny classes may also introduce a bias. Removal of Sd and E(SD) from their second chromosome location to create a Dp(2;Y)Sd E(SD) chromosome eliminates these problems, since any combination of Rsp alleles can be easily tested without resorting to recombinational techniques. Further, since these pairs of Rsp alleles are compared in their response to Dp Sd E(SD) in the same individual males, background variation and viability effects can be easily removed to allow fine-scale resolution of Rsp differences. Tests of all possible pairwise combination of six laboratory chromosomes in this way revealed at least three and possibly four different Rsp allelic classes. In addition, the hierarchical nature of the tests further allowed for determination of the presence of linked suppressors or enhancers of Sd activity. A sample of 11 second chromosomes selected from a group recently isolated from a natural population was also unambiguously ordered as to Rsp allelic status using this approach. The resultant pattern was similar to that obtained for the laboratory chromosomes, except for the not unexpected observation that the natural population apparently harbored more drive suppressors. The pattern of results obtained from these pairwise combinations of Rsp alleles supports the notion that there are no dominance interactions within the group, but that each responds more or less independently to Sd in giving sperm dysfunction.

  15. Hyperaccumulation of metals by Thlaspi caerulescens as affected by root development and Cd-Zn/Ca-Mg interactions.

    Saison, Carine; Schwartz, Christophe; Morel, Jean-Louis


    The aim of this work was to study, in a rhizobox experiment, the phytoextraction of metals by the hyperaccumulator plant Thlaspi caerulescens in relation to the heterogeneity of metal pollution. Six treatments were designed with soils containing various levels of metals. Homogeneous soils and inclusions of soils in other soil matrices were prepared in order to vary metal concentration and localization. Growth parameters of the plant (rosette diameter and shoot biomass) and localization of roots and shoot uptake of Zn, Cd, Ca, and Mg were determined after 10 weeks of growth. The plants grown on the polluted industrial soils provided a larger biomass and had lower mortality rates than those grown on the agricultural soil. Moreover, these plants accumulated more Zn and Cd (up to 17,516 and 375 mg kg(-1) DM, respectively) than plants grown on the agricultural soil (up to 7300 mg Zn kg(-1) and 83 mg Cd kg(-1) DM). The roots preferentially explored metal-contaminated areas. The exploration of polluted soil inclusions by the roots was associated with a higher extraction of metals. Zinc and Cd in the shoots of Thlaspi caerulescens were negatively correlated with Ca and Mg concentrations; however, the soil supply for these two elements was identical. This suggests that there is competition for the uptake of these elements and that Zn is preferentially accumulated.

  16. Toxicity of Methylcyclohexane and Its Effect on the Reproductive System in SD Rats

    Hyeon-Yeong Kim


    Conclusion: When injected repeatedly for 13 weeks, methylcyclohexane proved to be toxic for the liver, heart, and kidney at a high dose. The absolute toxic dose was 1,000 mg/kg/day, while the no observed adverse effect level was less than 100 mg/kg/day. The substance exerted little influence on the reproductive system.

  17. SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation

    King, Brett J.; Sapoznik, Kaitlyn A.; Elsner, Ann E.; Gast, Thomas J.; Papay, Joel A.; Clark, Christopher A.; Burns, Stephen A.


    ABSTRACT Purpose To investigate outer retinal tubulation (ORT) using spectral domain optical coherence tomography (SD-OCT) and an adaptive optics scanning laser ophthalmoscope (AOSLO). To document the frequency of ORT in atrophic retinal conditions and quantify ORT dimensions versus adjacent retinal layers. Methods SD-OCT images were reviewed for the presence of retinal atrophy, scarring, and/or exudation. The greatest width of each ORT was quantified. Inner and outer retinal thicknesses adjacent to and within the area of ORT were measured for 18 patients. AOSLO imaged ORTs in five subjects with direct and scattered light imaging. Results ORT was identified in 47 of 76 subjects (61.8%) and in 65 eyes via SD-OCT in a wide range of conditions and ages, and in peripapillary atrophy. ORTs appeared as finger-like projections in atrophy, seen in the en face images. AOSLO showed some ORTs with bright cones that guide light within atrophic areas. Multiply scattered light mode AOSLO visualized variegated lines (18–35 μm) radiating from ORTs. The ORTs’ width on OCT b-scan images varied from 70 to 509 μm. The inner retina at the ORT was significantly thinner than the adjacent retina, 135 vs.170 μm (P = .004), whereas the outer retina was significantly thicker, 115 vs. 80 μm (P = .03). Conclusions ORTs are quite common in eyes with retinal atrophy in various disorders. ORTs demonstrate surviving photoreceptors in tubular structures found within otherwise nonsupportive atrophic areas that lack retinal pigment epithelium and choriocapillaris. PMID:27984506


    Sri Hariyati Qodriyah


    Full Text Available Penelitian ini bertujuan untuk menghasilkan perangkat pembelajaran berupa SSP Tematik yang dapat mengembangkan karakter siswa kelas 2 sekolah dasar, meliputi karakter kejujuran dan kepedulian. Penelitian ini merupakan penelitian dan pengembangan yang terdiri dari tujuh tahap, yaitu studi pendahuluan, perencanaan, mengembangkan produk awal, uji coba awal, revisi produk utama, uji coba lapangan, dan revisi terhadap produk operasional. SSP yang dikembangkan dievaluasi oleh seorang ahli materi dan media untuk mengetahui validitasnya. Subjek uji coba berjumlah 90 siswa terdiri dari 23 siswa SD Sonosewu, Kasihan, Bantul, DIY sebagai subjek uji coba terbatas dan 33 siswa untuk kelas control dan 34 siswa untuk kelas eksperimen SD 1 Kadipiro, Kasihan, Bantul, DIY. Hasil penelitian ini berupa SSP yang meliputi: silabus, RPP, LKS, dan lembar penilaian. Hasil evaluasi dari ahli materi dan ahli media untuk menguji tingkat kevalidan SSP menyatakan bahwa SSP yang dikembangkan adalah valid dan berkategori “baik”. Hasil uji coba menunjukkan bahwa SSP yang dikembangkan dinyatakan layak serta memenuhi kriteria praktis dan efektif dalam mengembangkan karakter siswa. Pembelajaran dengan SSP yang dikembangkan mampu mengembangkan karakter kejujuran dan kepedulian. Kata Kunci: SSP, karakter jujur dan peduli   DEVELOPING THEMATIC INTEGRATIVE SSP FOR BUILDING THE CHARACTERS OF HONESTY AND CARE GRADE II STUDENT OF ELEMENTARY SCHOOL Abstract This study aims to produce integrated learning sets in the form of thematic SSP that can develop the characters of honesty and care of grade II students of elementary school. This was a research and development study consisting of seven steps, i.e. preliminary study, planning, preliminary product development, preliminary tryout, main product revision, field tryout, revision of operational product, operational product revision, and revision of the final product. The developed SSP was evaluated by a science subject expert to assess

  19. Nitrogen Source Stabilization of Quorum Sensing in the Pseudomonas aeruginosa Bioaugmentation Strain SD-1.

    Wang, Mei-Zhen; Lai, Bai-Min; Dandekar, Ajai A; Yang, Yu-Sheng; Li, Na; Yin, Jun; Shen, Dong-Sheng


    Pseudomonas aeruginosa SD-1 is efficient at degrading aromatic compounds and can therefore contribute to the bioremediation of wastewater. P. aeruginosa uses quorum sensing (QS) to regulate the production of numerous secreted "public goods." In wastewater bioaugmentation applications, there are myriad nitrogen sources, and we queried whether various nitrogen sources impact the stabilities of both QS and the bacterial populations. In a laboratory strain of P. aeruginosa, PAO1, the absence of a nitrogen source has been shown to destabilize these populations through the emergence of QS mutant "cheaters." We tested the ability of SD-1 to grow in casein broth, a condition that requires QS for growth, when the nitrogen source with either NH4Cl, NaNO3, or NaNO2 or with no added nitrogen source. There was great variability in susceptibility to invasion by QS mutant cheaters and, by extension, the stability of the SD-1 population. When grown with NH4Cl as an extra nitrogen source, no population collapse was observed; by contrast, two-thirds of cultures grown in the presence of NaNO2 collapsed. In the populations that collapsed, the frequency of social cheaters exceeded 40%. NaNO3 and NaNO2 directly favor QS mutants of P. aeruginosa SD-1. Although the mechanism by which these nitrogen sources act is not clear, these data indicate that the metabolism of nitrogen can affect the stability of bacterial populations, an important observation for continuing industrial applications with this species.IMPORTANCE Bioaugmentation as a method to help remediate wastewater pollutant streams holds significant potential to enhance traditional methods of treatment. Addition of microbes that can catabolize organic pollutants can be an effective method to remove several toxic compounds. Such bioaugmented strains of bacteria have been shown to be susceptible to competition from the microbiota that are present in wastewater streams, limiting their potential effectiveness. Here, we show that

  20. “太阳能十项全能”竞赛(SD)简述

    李苑; 宋晔皓


    1竞赛概况“太阳能十项全能竞赛”(Solar Decathlon,以下简称SD)是面对全球高校的住宅建筑与可再生能源科技竞赛,由美国能源部于2001年发起并首次主办,两年一届,旨在探索面向21世纪的太阳能建筑,推动建筑、节能与新技术的结合.

  1. Genetic Analysis of Genomic DNA in Shanxi Lean Meat Pigs (SD-Ⅲ Line)

    Wenjin ZHU; Yunguo ZHANG; Yongmei SU; Jing NI; Jianhua WU; Chuanjia GUO


    Abstract [Objective] This study aimed to detect the purity of Shanxi lean meat pigs. [Method] Eight primers were selected and used in the DNA fingerprinting technique amplified fragment length polymorphism (AFLP) to detect the purity of 30 Shanxi lean meat pigs. [Result] A total of 206 AFLP markers were obtained; 3-15 bands were obtained from each primer. The similarity index of population in Shanxi local pigs was 0.931 on average. [Conclusion] AFLP is suitable for detection of genomic DNA, and the genetic purity of SD-Ⅲ line is higher.

  2. Testing refined shell-model interactions in the sd shell: Coulomb excitation of Na26

    Siebeck, B; Blazhev, A; Reiter, P; Altenkirch, R; Bauer, C; Butler, P A; De Witte, H; Elseviers, J; Gaffney, L P; Hess, H; Huyse, M; Kröll, T; Lutter, R; Pakarinen, J; Pietralla, N; Radeck, F; Scheck, M; Schneiders, D; Sotty, C; Van Duppen, P; Vermeulen, M; Voulot, D; Warr, N; Wenander, F


    Background: Shell-model calculations crucially depend on the residual interaction used to approximate the nucleon-nucleon interaction. Recent improvements to the empirical universal sd interaction (USD) describing nuclei within the sd shell yielded two new interactions—USDA and USDB—causing changes in the theoretical description of these nuclei. Purpose: Transition matrix elements between excited states provide an excellent probe to examine the underlying shell structure. These observables provide a stringent test for the newly derived interactions. The nucleus Na26 with 7 valence neutrons and 3 valence protons outside the doubly-magic 16O core is used as a test case. Method: A radioactive beam experiment with Na26 (T1/2=1,07s) was performed at the REX-ISOLDE facility (CERN) using Coulomb excitation at safe energies below the Coulomb barrier. Scattered particles were detected with an annular Si detector in coincidence with γ rays observed by the segmented MINIBALL array. Coulomb excitation cross sections...


    M. Yusuf Setia Wardana


    Full Text Available Benefits of mathematics are to equip students with the ability to think logically, analytical, systematically, critically, and creatively, as well as the ability to cooperate. Based on observations in elementary school, there are 40% of students have not reached KKM and students have lack of critical abilities to understand math problems, and they have low activity of the study. One of models that can be applied is Two Stay Two Stray. The study used True Experimental Design with Posttest-Only Control Design. The population in this study was all fifth grade students of SD Negeri Semarang Rejosari 03. Data of critical thinking skills of the students in average on test of critical thinking skills mastery was 3.31 ≥ 2.67, it can be said to have a complete description. The conclusion is a model of Two Stay Two Stray being effective for critical thinking skills and mathematics learning outcomes of fifth grade students in SD Negeri Rejosari 03 Semarang. Keywords: two stay two stray model, critical thinking ability.

  4. Mechanical Properties Variation of B500SD High Ductility Reinforcement Regarding its Corrosion Degree

    Cobo, A.


    Full Text Available Corrosion effects on reinforcement become evident in the bar section reduction and in the variation of mechanical properties related to ductility. In this research work, 96 B500SD steel bars, previously subjected to different corrosion variables, have been tested. Results show that the elongation of the bars diminishes and the ratio between the maximum tensile stress and the elastic limit increases as the corrosion degree advances. These phenomena can be explained by studying the necking effect and the different steel composition through the manufacture process.

    Los efectos de la corrosión sobre las armaduras se manifiestan por la pérdida de sección y la variación de las propiedades mecánicas relacionadas con la ductilidad. En este trabajo se han ensayado a tracción 96 barras de acero B500SD que previamente se han sometido a niveles variables de corrosión. Los resultados muestran que los alargamientos de las barras disminuyen y el cociente entre la tensión máxima y el límite elástico aumenta conforme el nivel de corrosión avanza. A partir del estudio del efecto de entalla y de la distinta constitución metalográfica del acero a nivel de sección debido a su procedimiento de fabricación, se pueden explicar los fenómenos anteriores.

  5. Strategi Learning Community untuk Meningkatkan Keterampilan Menulis Wacana Deskriptif Siswa SD

    - Supriyadi


    Full Text Available Abstract: Implementing Learning-community Strategy to Improve the Ability of the Fifth-grade Students in Writing Descriptive Texts. This classroom action research describes how the implementa­tion of learning-community strategy improves the ability of the fifth-grade students of an elementary school in Gorontalo in writing descriptive texts. After two cycles, each involving the stages of planning, implementing, observing, and reflecting, the study indicates that the implementation of learning-­community strategy can improve the students' writing ability as reflected in the data obtained from par­ticipant observation, interview, and tests. Additionally, the strategy can improve the students' learning activities, collaborative skills, learning effectiveness, and social competence. Abstrak: Strategi Learning Community untuk Meningkatkan Keterampilan Menulis Wacana Deskriptif Siswa SD. Masalah yang dikaji dalam PTK ini adalah bagaimanakah strategi belajar learn­ing community dapat digunakan untuk meningkatkan keterampilan menulis wacana disekriptif pada siswa SD. PTK ini dilaksanakan dalam dua siklus. Prosedur penelitian terdiri atas lima langkah, yakni persiapan tindakan, implementasi tindakan, observasi, evaluasi, dan refleksi. Teknik pengambilan data terdiri atas observasi berpartisipasi, wawancara, dan tes yang dilakukan pada setiap akhir siklus. Hasil penelitian menunjukkan bahwa implementasi strategi belajar learning community dapat meningkatkan keterampilan menulis wacana deskriptif dan hasil belajar bahasa Indonesia siswa. Implementasi strategi learning community juga dapat meningkatkan aktivitas belajar, kolaborasi antarsiswa, keefektifan bela­jar, dan kompetensi sosial siswa.

  6. Menajemen Pendidikan dan Pelatihan Tindak Lanjut Uji Kompetensi Guru SD di LPMP Kalimantan Tengah

    Komalasari Komalasari


    Full Text Available Penelitian ini bertujuan untuk mengungkap: (1 perencanaan, (2 pengorganisasian, (3 pelaksananaan dan (4 pengawasan pada pendidikan dan pelatihan (diklat tindak lanjut uji kompetensi guru SD di LPMP Kalimantan Tengah. Penelitian ini menggunakan pendekatan kualitatif. Data dikumpulkan melalui wawancara, dokumentasi dan observasi dengan melibatkan pengelola diklat, fasilitator, dan peserta diklat Keabsahan data diukur dengan cara: (a trianggulasi, (b perpanjang-an waktu pelaksanaan penelitian, (c pengumpulan data secara terus menerus, (d penggunakan data yang berlimpah, (e pengecekan ulang, dan (f tanya jawab dengan teman sejawat Analisis data menggunakan teknik yang diajukan oleh Miles dan Huberman (1994 yaitu: (a reduksi data, (b penyajian data, dan (c verifikasL Hasil penelitian mengungkapkan bahwa: (1 perencanaan diklat belum optimal yang dilihat dari: (a asesmen kebutuhan, (b tujuan diklat, (c kesesuaian program dengan waktu diklat, (d waktu dan tempat pelaksanaan diklat, dan (e dana yang tersedia; (2 pengorganisasian belum optimal dilihat dari pembagian kerja dengan jabaran tanggung jawab masing-masing unit; (3 Pelayanan non akademik diklat sudah optimal namun pelaksanaan pembelajaran belum optimal, yang dilihat dari: (a standar jumlah peserta per kelas, (b bidang kompetensi guru, (c waktu, dan (d kelengkapan bahan diklat; dan (4 pengawasan belum terlaksana dengan baik, dilihat dari pencapaian tujuan dan partisipasi peserta Kata kunci: pendidikan dan pelatihan, uji kompetensi, guru SD.

  7. Analysis of the variability in the sdB star KIC 10670103: DFA approach

    Zebende, Gilney F.; Fernandez, Basilio F.; Pereira, Marildo G.


    The brightness variation of the stars is an object of study in astronomy and astrophysics for representing the rich inherent source of physical information. Launched in 2009, the Kepler spacecraft with the primary mission of identifying equivalent to the Earth by the Sun transits also gave birth to thousands of light curves of targets of scientific interest. KIC 10670103, the richest pulsating sub-dwarf B (sdB) star, is one of the many stars identified by the mission. With 3.72 yr of Kepler spacecraft observations, we analysed in this paper the light curve of this sdB star, by the detrended fluctuation analysis (DFA) method. The behaviour of this pulsating star reveals self-affinity at specific time-scales, with changes in DFA exponent, αDFA. This fact suggests some light variability in KIC 10670103, as for example, from a non-periodic to a periodic case, among others. Therefore, we propose to connect the pulsation pattern of the KIC 10670103 star, which presents trends and non-stationarity, with the αDFA exponent. In this sense, we obtain five values of αDFA related to the light variability properties of KIC 10670103. A pictorial figure will describe the relationship between these variables.

  8. The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats.

    Li, Shangchun; Chen, Jun; Xie, Ping; Guo, Xiaochun; Fan, Huihui; Yu, Dezhao; Zeng, Cheng; Chen, Liang


    In the present study, we investigated the role of glutathione (GSH) and its related enzymes in Sprague Dawley (SD) rats subjected to microcystin-leucine-arginine (MCLR)-induced hepatotoxicity. SD rats were intraperitoneally (i.p.) injected with MCLR after pretreating with or without buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH synthesis. The depletion of GSH with BSO enhanced MCLR-induced oxidative stress, resulting in more severe liver damage and higher MCLR accumulation. Similarly, the contents of malondialdehyde (MDA), total GSH (T-GSH), oxidized GSH (GSSG) and GSH were significantly enhanced in BSO pretreated rats following MCLR treatment. The study showed that the transcription of GSH-related enzymes such as glutathione-S-transferase (GST), γ-glutamylcysteine synthetase (γ-GCS), glutathione reductase (GR) varied in different ways (expect for glutathione peroxidase (GPx), whose gene expression was induced in all treated groups) with or without BSO pretreatment before MCLR exposure, suggesting an adaptative response of GSH-related enzymes at transcription level to combat enhancement of oxidative stress induced by MCLR when pretreated with BSO. These data suggested the tissues with low GSH concentration are highly vulnerable to MCLR toxicity and GSH was critical for the detoxification in MCLR-induced hepatotoxicity in vivo.

  9. Stripped red giants - Helium core white dwarf progenitors and their sdB siblings

    Heber, Ulrich


    Some gaps in the mosaic of binary star evolution have recently been filled by the discoveries of helium-core white dwarf progenitors (often called extremely low mass (ELM) white dwarfs) as stripped cores of first-giant branch objects. Two varieties can be distinguished. One class is made up by SB1 binaries, companions being white dwarfs as well, another class, the so-called EL CVn stars, are composite spectrum binaries, with A-Type companions. Pulsating stars are found among both classes. A riddle is posed by the apparently single objects. There is a one-to-one correspondence of the phenomena found for these new classes of star to those observed for sdB stars. In fact, standard evolutionary scenarios explain the origin of sdB stars as red giants that have been stripped close to the tip of first red giant branch. A subgroup of subluminous B stars can also be identified as stripped helium-cores of red giants. They form an extension of the ELM sequence to higher temperatures. Hence low mass white dwarfs of heliu...

  10. Radii in the $sd$ shell and the $s_{1/2}$ "halo" orbit: A game changer

    Bonnard, J


    Proton radii of nuclei in the $sd$ shell depart appreciably from the asymptotic law, $\\rho_{\\pi}=\\rho_0A^{1/3}$. The departure exhibits systematic trends fairly well described by a single phenomenological term in the Duflo-Zuker formulation, which also happens to explain the sudden increase in slope in the isotope shifts of several chains at neutron number $N=28$. It was recently shown that this term is associated with the abnormally large size of the $s_{1/2}$ and $p$ orbits in the $sd$ and $pf$ shells respectively. Further to explore the problem, we propose to calculate microscopically radii in the former. Since the (square) radius is basically a one body operator, its evolution is dictated by single particle occupancies determined by shell model calculations. Assuming that the departure from the asymptotic form is entirely due to the $s_{1/2}$ orbit, the expectation value $\\langle s_{1/2}|r^2|s_{1/2}\\rangle$ is determined by demanding that its evolution be such as to describe well nuclear radii. It does, f...

  11. Complex dynamics of an archetypal self-excited SD oscillator driven by moving belt friction

    Zhi-Xin, Li; Qing-Jie, Cao; Léger, Alain


    We propose an archetypal self-excited system driven by moving belt friction, which is constructed with the smooth and discontinuous (SD) oscillator proposed by the Cao et al. and the classical moving belt. The moving belt friction is modeled as the Coulomb friction to formulate the mathematical model of the proposed self-excited SD oscillator. The equilibrium states of the unperturbed system are obtained to show the complex equilibrium bifurcations. Phase portraits are depicted to present the hyperbolic structure transition, the multiple stick regions, and the friction-induced asymmetry phenomena. The numerical simulations are carried out to demonstrate the friction-induced vibration of multiple stick-slip phenomena and the stick-slip chaos in the perturbed self-excited system. The results presented here provide an opportunity for us to get insight into the mechanism of the complex friction-induced nonlinear dynamics in mechanical engineering and geography. Project supported by the National Natural Science Foundation of China (Grant Nos. 11372082 and 11572096) and the National Basic Research Program of China (Grant No. 2015CB057405).

  12. Comparison of rizatriptan 5 mg and 10 mg tablets and sumatriptan 25 mg and 50 mg tablets.

    Kolodny, A; Polis, A; Battisti, W P; Johnson-Pratt, L; Skobieranda, F


    This randomized, double-blind, two-attack, placebo-controlled, crossover study explored the efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 50 mg as well as rizatriptan 5 mg compared with sumatriptan 25 mg in the acute treatment of migraine. Following randomization to one of six possible treatment sequences, patients (n = 1447) treated two sequential attacks, of moderate or severe intensity, separated by at least 5 days. Patients assessed pain severity, migraine-associated symptoms, and functional disability at 0.5, 1, 1.5, and 2 h post treatment. Compared with placebo, all treatments were effective. On the primary endpoint of time to pain relief, rizatriptan 10 mg was not statistically different from sumatriptan 50 mg [odds ratio (OR) 1.10, P = 0.161], and rizatriptan 5 mg was statistically superior to sumatriptan 25 mg (OR 1.22, P = 0.007). In general, rizatriptan 10 mg and 5 mg treatment resulted in improvement compared with the corresponding doses of sumatriptan on measures of pain severity, migraine symptoms, and functional disability and the 5-mg dose reached statistical significance on almost all measures. All treatments were generally well tolerated.

  13. Teratogenicity of Glufosinate-ammonium TC in Rat(SD)%草铵膦原药对大鼠致畸试验

    由宇润; 王智琴; 张炫; 吕耀中; 王捷


    [Aims]Glufosinate-ammonium 95%TC was submitted to the teratogenic toxicology laboratory for evaluation of poumaally tmatogenic toxicity in Sprague Dawley(SD)rats.The purpose of the teratogenic toxicology toxicity studywas to determine general toxic effects on pregnant rats.The embryo toxicity on embryonic rats and teratogenicity. [Methods]The study was conducted to pregnant Sprague Dawley(SD)rats with 30,70,150 ms/kg b.w. And a negative conuol group,acording to the Teratogenicity Test.[Results]Mild general toxic effects on pregant rats,the disappearance of second breastbone on tetuses,and no temtogenicity on fetuses were found at 70 mg/kg b.w. Dose level.Severe general toxic effects on pregant mrs,embryo toxicity On embryonic rats,the disappearance of second breastbone on tetuses,and ribs anamorphosis on individual fetus were found at 150 mg/kg b.w.dose level.[Conclusions]The test showed that mild general toxic effects,the disappearance of second breastbone on tetuses,and no teratogenicity on fetuses were found at 70 mg/kg b.W. Dose level and severe general toxic effects,embryo toxicity on embryonic rats,disappearance of second breastbone and ribs anamorphosis on individual fetus Were found at 150 ms/kg b.w.dose level.%[目的]检测95%草铵膦原药对妊娠大鼠是否有母体毒性,胚胎毒性以及致畸毒性.[方法]应用SpragueDawley(SD)大鼠为实验动物,设计30、70、150 mg/kg b.w.三个剂量组和1个阴性对照组进行了草铵膦原药的“致畸试验”.[结果]经口灌胃95%草铵膦原药70 mg/kg b.w.引起妊娠母鼠轻微母体毒性反应和胎鼠体质量增长缓慢,部分胎鼠出现第2胸骨缺失.95%草铵膦原药150 mg/kg b.w.引起妊娠母鼠严重的母体毒性反应、母体平均增重和胎鼠平均身长、尾长和体质量增长缓慢,部分胎鼠出现角尾和弯尾或第2胸骨缺失或肋骨缺失或短.[结论]经口灌胃95%草铵膦原药70 mg/kg b.w.可引起轻微母体毒性反应、胎鼠毒性

  14. Substitution of Mn for Mg in MgB_2*

    Fitzpatrick, Michael D.; Johnston, David C.; Miller, Lance L.; Hill, Julienne M.


    The study of solid solutions in which the Mg in MgB2 is partially replaced by magnetic 3d or 4f atoms can potentially reveal important information on the superconducting state of MgB_2. As an end-member of the hypothetical Mg_1-xMn_xB2 system, MnB2 is isostructural with MgB2 and is an antiferromagnet below TN = 760 K which becomes canted at 157 K. A previous study by Moritomo et al.[1] examined the structure and properties of multi-phase samples with 0.01J. Phys. Soc. Japan b70, 1889 (2001).; “Effects of transition metal doping in MgB2 superconductor", Y. Moritomo at al. arXiv:cond-mat/0104568.

  15. Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation.

    Twa, Michael D; Schulle, Krystal L; Chiu, Stephanie J; Farsiu, Sina; Berntsen, David A


    Spectral domain optical coherence tomography (SD-OCT) imaging permits in vivo visualization of the choroid with micron-level resolution over wide areas and is of interest for studies of ocular growth and myopia control. We evaluated the speed, repeatability, and accuracy of a new image segmentation method to quantify choroid thickness compared to manual segmentation. Two macular volumetric scans (25 × 30°) were taken from 30 eyes of 30 young adult subjects in two sessions, 1 hour apart. A single rater manually delineated choroid thickness as the distance between Bruch's membrane and sclera across three B-scans (foveal, inferior, and superior-most scan locations). Manual segmentation was compared to an automated method based on graph theory, dynamic programming, and wavelet-based texture analysis. Segmentation performance comparisons included processing speed, choroid thickness measurements across the foveal horizontal midline, and measurement repeatability (95% limits of agreement (LoA)). Subjects were healthy young adults (n = 30; 24 ± 2 years; mean ± SD; 63% female) with spherical equivalent refractive error of -3.46 ± 2.69D (range: +2.62 to -8.50D). Manual segmentation took 200 times longer than automated segmentation (780 vs. 4 seconds). Mean choroid thickness at the foveal center was 263 ± 24 μm (manual) and 259 ± 23 μm (automated), and this difference was not significant (p = 0.10). Regional segmentation errors across the foveal horizontal midline (±15°) were ≤9 μm (median) except for nasal-most regions closest to the nasal peripapillary margin-15 degrees (19 μm) and 12 degrees (16 μm) from the foveal center. Repeatability of choroidal thickness measurements had similar repeatability between segmentation methods (manual LoA: ±15 μm; automated LoA: ±14 μm). Automated segmentation of SD-OCT data by graph theory and dynamic programming is a fast, accurate, and reliable method to delineate the choroid. This approach will facilitate

  16. Purification, characterization and anti-aging capacity of mycelia zinc polysaccharide by Lentinus edodes SD-08.

    Wang, Liqin; Wang, Cuiqin; Gao, Xia; Xu, Nuo; Lin, Lin; Zhao, Huajie; Jia, Shouhua; Jia, Le


    In the modern society, aging had been a major problem. People may rely on many medicines to delay it. However, lots of medicines were chemosynthetic, and they would do a bad side-effect on human body. Microbial sources could be used as a potential means of producing natural antioxidants. Lentinus edodes, commercial obtained in daily life, had recently become more attractive in physiological research. Zinc was now considered as a major element in assuring the correct functioning of an organism and essential for maintaining coordination of the major homeostatic networks. To investigate the bioconversion of zinc and the physiological effects of their complex (MZPS), the present studies were processed. Mycelia polysaccharides (MPS) and mycelia zinc polysaccharides (MZPS) of Lentinus edodes SD-08 were extracted by hot water leaching and purified by DEAE-52 cellulose anion-exchange column chromatography separately. The zinc content was determined by flame atomic absorption spectrometry. The evaluation of monosaccharide compositions and proportions used gas chromatogram. The analysis of molecular weight used HPGPC chromatogram. The typical structure of polysaccharide was evaluated by IR spectrum. The antioxidant activities in vitro measured through reducing power, the scavenging effects on hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. The anti-aging activities in vivo measured through the total antioxidant capacity (T-AOC), GSH peroxide (GSH-Px), superoxide dismutase (SOD) and the contents of malondialdehyde (MDA). MPS and MZPS of Lentinus edodes SD-08 were extracted and purified by DEAE-52 cellulose anion-exchange column chromatography separately, and four fractions (MPS-1, MPS-2, MZPS-1 and MZPS-2) were obtained. In addition, MPS composing of rhamnose, arabinose and mannose (molar proportion = 1.75:1.00:3.02) and MZPS containing rhamnose, arabinose, mannose and glucose (molar proportion = 7.19:2.26:1.00:8.39) were investigated by gas chromatography

  17. Effect of alprostadil combined with Diammonium glycyrrhizinate on renal interstitial fibrosis in SD rats

    Wei-Yan Cai; You-Yi Gu; Ai-Min Li; Huan-Qin Cui; Yi Yao


    Objective:To observe effect of alprostadil combined with Diammonium glycyrrhizinate on renal interstitial fibrosis in SD rats. Methods:A total of 75 SD rats were randomly divided into A, B, C, D, E groups with 15 in each group. Rats in group A served as the control group received just only but tissue separation without modeling operation, while model of unilateral ureteral obstruction (UUO) was established in B, C, D, E groups. Rats in A, B group were given saline lavage placebo treatment, while rats in C, D, E groups were given diammonium glycyrrhizinate and alprostadil injection. Five rats were sacrificed 1, 2, 3 weeks after modeling, serum creatinine level of femoral venous blood was determined. Transforming growth factor-β1 (TGF-β1) and concentration of connective tissue growth factor (CTGF) were also detected by using ELISA. Line renal interstitial tissue was taken after HE staining, renal interstitial TGF - β1 and CTGF expression were detected by using immunohistochemical method. Results:Serum creatinine levels of B, C, D, E group at different time points in were significantly higher than that of group A (P0.05);while serum and kidney tissue TGF-β1, concentration of CREA, expression of rats in B, C, D, E groups showed a gradual increasing trend over time. TGF-β1 and CREF of Group B in serum and kidney tissues at each time point were significantly higher than that of the other groups (P<0.05). TGF-β1 and CREF of Group E in serum and kidney tissues at each time point were significantly lower than that of B, C, D group at all time points in serum and kidney tissues (P<0.05). Conclusions:Alprostadil combined with diammonium glycyrrhizinate can significantly lower the expression of TGF-β1 and CTGF in serum and tissues of SD rat with renal interstitial fibrosis, thus inhibit rat renal interstitial fibrosis process. It has synergy protective effect.

  18. Mesoporous carbon stabilized MgO nanoparticles synthesized by pyrolysis of MgCl2 preloaded waste biomass for highly efficient CO2 capture.

    Liu, Wu-Jun; Jiang, Hong; Tian, Ke; Ding, Yan-Wei; Yu, Han-Qing


    Anthropogenic CO2 emission makes significant contribution to global climate change and CO2 capture and storage is a currently a preferred technology to change the trajectory toward irreversible global warming. In this work, we reported a new strategy that the inexhaustible MgCl2 in seawater and the abundantly available biomass waste can be utilized to prepare mesoporous carbon stabilized MgO nanoparticles (mPC-MgO) for CO2 capture. The mPC-MgO showed excellent performance in the CO2 capture process with the maximum capacity of 5.45 mol kg(-1), much higher than many other MgO based CO2 trappers. The CO2 capture capacity of the mPC-MgO material kept almost unchanged in 19-run cyclic reuse, and can be regenerated at low temperature. The mechanism for the CO2 capture by the mPC-MgO was investigated by FTIR and XPS, and the results indicated that the high CO2 capture capacity and the favorable selectivity of the as-prepared materials were mainly attributed to their special structure (i.e., surface area, functional groups, and the MgO NPs). This work would open up a new pathway to slow down global warming as well as resolve the pollution of waste biomass.

  19. Establishment and Improvement of SD Rat Model of Left Lung Transplantation%SD 大鼠左肺移植模型的建立与改进

    戴斌; 唐建; 吴起才; 黄磊; 古亮


    目的:改进大鼠原位左肺移植技术,建立快速、安全、可重复性强的大鼠肺移植动物模型的方法。方法SPF 级健康雄性 SD 大鼠90只,体质量300~350 g。其中60只作为供、受体,受体略大于供体,供、受体间体质量差不超过20 g,运用三袖套法吻合左肺动、静脉及支气管以建立大鼠左肺移植模型,移植成功后的受体在48 h 后取肺静脉血进行血气分析(PO2、PCO2);30只为对照组,肺静脉取血进行血气分析。观察记录大鼠肺移植供肺获取、套管及受体移植时间;移植肺血液循环及膨胀情况;移植肺与对照组血气分析结果比较。结果完成大鼠肺移植手术30例,成功27例,失败3例(肺静脉撕裂1例,脱机失败1例,肺动脉扭转1例)。大鼠供肺获取时间为(13.5±2.0)min,供肺套管时间为(15.5±2.5)min;游离大鼠受体左侧肺门部动、静脉及支气管并套线、结扎时间为(19.2±2.0)min;吻合时间为(18.5±4.0)min。在先开放肺动脉血流,接着开放肺静脉血流后,移植的左侧肺叶颜色均匀一致的红润,左肺血流得到充分的灌注,静脉充盈良好,回流畅通;恢复机械通气后,27例移植肺膨胀良好。左肺移植成功48 h 后,肺移植大鼠右侧肺门夹闭5 min 后 PO2为(7.88±0.84)kPa,PCO2为(6.67±1.09)kPa;对照组大鼠夹闭右侧肺门5 min 后肺静脉 PO2为(8.55±0.97)kPa,PCO2为(6.20±0.88)kPa。2组 PO2比较差异有统计学意义(P <0.05),PCO2比较差异无统计学意义(P >0.05)。结论改进后的肺移植技术可为大鼠肺移植的相关研究提供稳定、可靠及可重复的动物模型。%ABSTRACT:Objective To improve the technique of orthotopic left lung transplantation in rats, and to establish a fast,safe and repeatable method for rat lung transplantation.Methods Ninety healthy male SPF

  20. 基于SPI的SD卡驱动软件设计%Design of SD Card Drive Software Based on SPI

    杨怀德; 朴希南


    SD卡是一种基于半导体闪存的新的存储介质,广泛地应用在便携式设备上。按照SD卡规范的描述,SD卡提供了两种通信协议:SD模式和SPI模式,驱动可以选择任意一种模式来实现。目前基于SPI的SD卡驱动研究还比较少.研究基于SPI总线模式的SD卡驱动软件设计并分析SD卡的初始化过程和读写过程。%SD card is a flash memory storage media based on new semiconductor, widely used in portable devices. Described in accordance with SD card specification, SD card provides two communica- tion protocols: SD mode and SPI mode, the driver can choose either mode to achieve. Current SPI-based SD card-driven research is still relatively small, on the basis of the SPI bus mode designs SD card driver software and analyses the initialization and read-write process of SD card.

  1. Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma.

    Fadakar, Puran; Akbari, Abolfazl; Ghassemi, Fariba; Mobini, Gholam Reza; Mohebi, Masoumeh; Bolhassani, Manzar; Abed Khojasteh, Hoda; Heidari, Mansour


    Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including a miR-17/92 cluster in retinoblastoma cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays. Then, the expression patterns of four miRNAs (18a, 20a, 22, and 34a) were investigated in the treated SD-208 (0.0, 1, 2 and 3 µM) and untreated Y-79 cells. A remarkable inhibition of the cell proliferation was found in Y-79 cells treated with SD-208 versus untreated cells. Also, the expression changes were observed in miRNAs 18a, 20a, 22 and 34a in response to SD-208 treatment (P<0.05). The findings of the present study suggest that the anti-cancer effect of SD-208 may be exerted due to the regulation of specific miRNAs, at least in this particular retinoblastoma cell line. To the best of the researchers' knowledge, this is the first report demonstrating that the SD-208 could alter the expression of tumor suppressive miRNAs as well as oncomiRs in vitro. In conclusion, the present data suggest that SD-208 could be an alternative agent in retinoblastoma treatment.

  2. High spin structure of {sup 35}Cl and the sd-fp shell gap

    Kshetri, Ritesh [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Saha Sarkar, M. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India)]. E-mail:; Ray, Indrani [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Banerjee, P. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Sarkar, S. [Department of Physics, Bengal Engineering and Science University, Shibpur, Howrah 711103 (India); Raut, Rajarshi [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Goswami, A. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Chatterjee, J.M. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Chattopadhyay, S. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Datta Pramanik, U. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Mukherjee, A. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Dey, C.C. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Bhattacharya, S. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Dasmahapatra, B. [Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700064 (India); Bhowal, Samit [Department of Physics, Surendranath Evening College, Kolkata 700009 (India); Gangopadhyay, G. [University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009 (India); Datta, P. [Anandamohan College, 102/1, Raja Rammohan Sarani, Kolkata 700009 (India); Jain, H.C. [Tata Institute of Fundamental Research, Mumbai 400005 (India); Bhowmik, R.K. [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India); Muralithar, S.; Singh, R.P.; Kumar, R. [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India)


    The high spin states of {sup 35}Cl have been studied by in-beam {gamma}-spectroscopy following the fusion-evaporation reaction {sup 12}C({sup 28}Si,{alpha}p){sup 35}Cl at E{sub lab}=70 and 88 MeV, using the Indian National Gamma (Clover) Array (INGA). Lifetimes of six new excited states have been estimated for the first time. To understand the underlying structure of the levels and transition mechanisms, experimental results have been compared with those from the large basis cross-shell shell model calculations. Involvement of orbitals from fp shell and squeezing of the sd-fp shell gap seem to be essential for reliable reproduction of high spin states.

  3. Effects of Λ hyperon on localization and clustering in p- and sd-shell nuclei

    Xu, Renli, E-mail: [Key Laboratory of Modern Acoustics, Department of Physics, Nanjing University, Nanjing 210093 (China); Wu, Chen, E-mail: [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Ren, Zhongzhou, E-mail: [Key Laboratory of Modern Acoustics, Department of Physics, Nanjing University, Nanjing 210093 (China); Center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator, Lanzhou 730000 (China); Joint Center of Nuclear Science and Technology, Nanjing University, Nanjing 210093 (China)


    In the present work, the properties of several deformed p- and sd-shell Λ-hypernuclei have been investigated using the self-consistent relativistic mean field theory. The calculated ground state energies are consistent with the experimental values. In particular, the possibility of localization and clustering in deformed nuclei is discussed, concentrating on experimentally accessible light nuclei. Utilizing the framework of relativistic mean field model, our calculation predicts formation of clusterlike structure in the ground state of {sup 28}Si and {sup 32}S, while the core nuclei in {sup 29}{sub Λ}Si and {sup 33}{sub Λ}S show a delocalized formation in the presence hyperon depending on the nuclear effective interaction.

  4. Spectral analysis of the sdO standard star Feige 34

    Latour, M; Green, E M; Fontaine, G


    We present our current work on the spectral analysis of the hot sdO star Feige 34. We combine high S/N optical spectra and fully-blanketed non-LTE model atmospheres to derive its fundamental parameters (Teff, log g) and helium abundance. Our best fits indicate Teff =63 000 K, log g=6.0 and log N(He)/N(H)=-1.8. We also use available ultraviolet spectra (IUE and FUSE) to measure metal abundances. We find the star to be enriched in iron and nickel by a factor of ten with respect to the solar values, while lighter elements have subsolar abundances. The FUSE spectrum suggests that the spectral lines could be broadened by rotation.

  5. Collective excitations in deformed sd-shell nuclei from realistic interactions

    Erler, Bastian


    Background: Collective excitations of nuclei and their theoretical descriptions provide an insight into the structure of nuclei. Replacing traditional phenomenological interactions with unitarily transformed realistic nucleon-nucleon interactions increases the predictive power of the theoretical calculations for exotic or deformed nuclei. Purpose: Extend the application of realistic interactions to deformed nuclei and compare the performance of different interactions, including phenomenological interactions, for collective excitations in the sd-shell. Method: Ground-state energies and charge radii of 20-Ne, 28-Si and 32-S are calculated with the Hartree-Fock method. Transition strengths and transition densities are obtained in the Random Phase Approximation with explicit angular-momentum projection. Results: Strength distributions for monopole, dipole and quadrupole excitations are analyzed and compared to experimental data. Transition densities give insight into the structure of collective excitations in def...

  6. Source identification in acoustics and structural mechanics using Sierra/SD.

    Walsh, Timothy Francis; Aquino, Wilkins [Duke University Durham, NC; Ross, Michael


    In this report we derive both time and frequency-domain methods for inverse identification of sources in elastodynamics and acoustics. The inverse/design problem is cast in a PDE-constrained optimization framework with efficient computation of gradients using the adjoint method. The implementation of source inversion in Sierra/SD is described, and results from both time and frequency domain source inversion are compared to actual experimental data for a weapon store used in captive carry on a military aircraft. The inverse methodology is advantageous in that it provides a method for creating ground based acoustic and vibration tests that can reduce the actual number of flight tests, and thus, saving costs and time for the program.

  7. Simulation and Optimization of One Live Pig Low-Carbon Industry Chain Using SD-RCCM

    Jiuping Xu


    Full Text Available The destruction of the natural environment has been drawing more and more attention. Developing low-carbon industry chains is an effective solution to the conflict between rapid economic growth and high CO2 emissions. Summarizing various traditional and new industry chain sustainable development, live pig industry was chosen as a typical industry chain to study low-carbon development using a system dynamics and random chance-constrained model (SD-RCCM. Leshan, a world natural and cultural heritage area in China, was selected as a typical city to analyze the low-carbon pig industry. Three different programs based on distribution ratios were selected to study this industry. The results showed that program 1, which considers both environmental and economic benefits, realizes sustainable development. In order to extend the pig industry chain and fully utilize pig ordure and other waste, introducing a Clean Development Mechanism (CDM and household biogas exploitation program is recommended.

  8. Improved determination of the atmospheric parameters of the pulsating sdB star Feige 48

    Chayer P.


    Full Text Available Given the importance of Feige 48 as an sdB pulsator, we sought to obtain the best possible estimates of its spectroscopic parameters with a grid of NLTE metal-blanketed model atmospheres constructed especially for that star. This small grid of 150 models includes 8 metallic elements whose abundances have been determined previously and reported in the literature. Our fitting procedure found the following parameters for Feige 48: Teff = 29 504 K, log g = 5.41 and log N(He/N(H = −2.90. These results are in very good agreement with previous spectroscopic estimates (which generally ignore either NLTE effects or metal blanketing, thus indicating that metal line-blanketing in NLTE – modeled for the first time here – is not a dominant factor in the atmosphere of Feige 48.

  9. Design and Analysis of SD_DWCA - A Mobility based clustering of Homogeneous MANETs

    Janakiraman, T N


    This paper deals with the design and analysis of the distributed weighted clustering algorithm SD_DWCA proposed for homogeneous mobile ad hoc networks. It is a connectivity, mobility and energy based clustering algorithm which is suitable for scalable ad hoc networks. The algorithm uses a new graph parameter called strong degree defined based on the quality of neighbours of a node. The parameters are so chosen to ensure high connectivity, cluster stability and energy efficient communication among nodes of high dynamic nature. This paper also includes the experimental results of the algorithm implemented using the network simulator NS2. The experimental results show that the algorithm is suitable for high speed networks and generate stable clusters with less maintenance overhead.

  10. Two-nucleon excitation from $p$ to $sd$ shell in $^{12,14}$C

    Yuan, Cenxi; Lan, Nianwu; Fang, Youjun


    The effect of the two-nucleon excitation from $p$ to $sd$ shell is discussed in $^{12}$C and $^{14}$C in the frame work of shell model. The recently suggested shell-model Hamiltonian YSOX provides an suitable tool to investigate the $2~\\hbar\\omega$ excitation in $psd$ region. Because the strength of the $$ interaction, which represents the interaction between the $0~\\hbar\\omega$ and $2~\\hbar\\omega$ configurations, is considered in the construction of the YSOX. The level of $^{12}$C is almost independent on the $$ interaction, but excitation energies of certain states in $^{14}$C are strongly affected by it. Further investigation shows that the percentage of $2~\\hbar\\omega$ configuration in these states is quite different from that of the ground state.

  11. Design and Analysis of SD_DWCA - A Mobility Based Clustering of Homogeneous MANETs

    T.N. Janakiraman


    Full Text Available This paper deals with the design and analysis of the distributed weighted clustering algorithm SD_DWCAproposed for homogeneous mobile ad hoc networks. It is a connectivity, mobility and energy based clustering algorithm which is suitable for scalable ad hoc networks. The algorithm uses a new graph parameter called strong degree defined based on the quality of neighbours of a node. The parameters are so chosen to ensure high connectivity, cluster stability and energy efficient communication among nodes of high dynamic nature. This paper also includes the experimental results of the algorithm implementedusing the network simulator NS2. The experimental results show that the algorithm is suitable for highspeed networks and generate stable clusters with less maintenance overhead.

  12. Microsporum fulvum IBRL SD3: as novel isolate for chicken feathers degradation.

    Darah, I; Nur-Diyana, A; Nurul-Husna, S; Jain, K; Lim, Sheh-Hong


    Keratinous wastes have increasingly become a problem and accumulate in the environment mainly in the form of feathers, generated mainly from a large number of poultry industries. As keratins are very difficult to degrade by general proteases, they pose a major environmental problem. Therefore, microorganisms which would effectively degrade keratins are needed for recycling such wastes. A geophilic dermatophyte, Microsporum fulvum IBRL SD3 which was isolated from a soil sample collected from a chicken feather dumping site using a baiting technique, was capable to produce keratinase significantly. The crude keratinase was able to degrade whole chicken feathers effectively. The end product of the degradation was protein that contained essential amino acids and may have potential application in animal feed production. Thus, M. fulvum could be a novel organism to produce keratinase for chicken feathers degradation.

  13. Penelitian tentang ukuran acuan sepatu pelajar wanita indonesia tingkat SD, SLTP dan SLTA

    Sri Bandi


    Full Text Available The study was subjected to 500 Indonesia School girls from North Sumatra Province (Medan, West Java Province (Bandung, Central – Java Province (Semarang, East-Java Province (Surabaya and DKI Jaya. 100 samples of foot sizes which represented foot sizes of SD, SLTP and SLTA School girls werw taken from each province. By analyzing the data of foot sizes of the school girls, a suggestion on design of shoe lasts seritable with the shape and type of foot, fits and conform the requirements to be used as lost in shoe manufacturing could be proposed. The results of data analyse shown that : 1. The length of soles ranged from 30-35, 5 PS, the mean of which was 33 PS. 2. Instep girth ranged withim E, F, G, I.3. The foot sizes scattered between (4-17 years of age at (32-35 PS.

  14. Helium abundances and the helium isotope anomaly of sdB stars

    Geier, S; Edelmann, H; Morales-Rueda, L; Kilkenny, D; O'Donoghue, D; Marsh, T R; Copperwheat, C


    Helium abundances and atmospheric parameters have been determined from high resolution spectra for a new sample of 46 bright hot subdwarf B (sdB) stars. The helium abundances have been measured with high accuracy. We confirm the correlation of helium abundance with temperature and the existence of two distinct sequences in helium abundance found previously. We focused on isotopic shifts of helium lines and found helium-3 to be strongly enriched in 8 of our programme stars. Most of these stars cluster in a small temperature range between 27000 K and 31000 K very similar to the known helium-3-rich main sequence B stars, which cluster at somewhat lower temperatures. This phenomenon is most probably related to diffusion processes in the atmosphere, but poses a challenge to diffusion models.

  15. Effect of fermented milk containing Lactobacillus rhamnosus SD11 on oral microbiota of healthy volunteers: A randomized clinical trial.

    Rungsri, P; Akkarachaneeyakorn, N; Wongsuwanlert, M; Piwat, S; Nantarakchaikul, P; Teanpaisan, R


    The aims of this study were to evaluate whether short-term consumption of fermented milk containing Lactobacillus rhamnosus SD11 affected levels of oral microbiota in vivo and whether L. rhamnosus SD11 could colonize in the human mouth. We also monitored for potential side effects of the probiotic. The applicability of using L. rhamnosus SD11 compared with Lactobacillus bulgaricus as a starter culture for fermented milk was evaluated. After informed consent, 43 healthy young adults were recruited and randomly assigned to either the probiotic or control group and received fermented milk containing L. rhamnosus SD11 or L. bulgaricus, respectively, once daily for 4 wk. The numbers of mutans streptococci, lactobacilli, and total bacteria in saliva were counted at baseline and then after 4 and 8 wk. An oral examination was performed at baseline and after 8 wk. The persistence of L. rhamnosus SD11 was investigated by DNA fingerprinting using arbitrary primer-PCR. Results demonstrated that statistically significant reductions in mutans streptococci and total bacteria were observed in the probiotic group compared with the control group, and the number of lactobacilli was significantly increased in both groups after receiving fermented milks. Lactobacillus rhamnosus SD11 could be detected (in >80% of subjects) up to 4 wk following cessation of dosing among subjects in the probiotic group. No side effects were reported. Thus, L. rhamnosus SD11 could be used as a starter culture for fermented milk. Daily consumption of L. rhamnosus SD11-containing fermented milk for 4 wk may have beneficial effects on oral health by reducing salivary levels of mutans streptococci. The probiotic was apparently able to colonize the oral cavity for a longer time than previously reported. However, the potential benefits of probiotic L. rhamnosus SD11 on oral health require further evaluation with a larger group of volunteers in a longer-term study. Copyright © 2017 American Dairy Science

  16. Lactogenic Activity of an Enzymatic Hydrolysate from Octopus vulgaris and Carica papaya in SD Rats.

    Cai, Bingna; Chen, Hua; Sun, Han; Sun, Huili; Wan, Peng; Chen, Deke; Pan, Jianyu


    The traditional Chinese medicine theory believes that octopus papaya soup can stimulate milk production in lactating women. The objective of this study was to determine whether dietary supplementation with an enzymatic hydrolysate of Octopus vulgaris and Carica papaya (EHOC) could increase milk production and nutritional indexes in Sprague Dawley (SD) rats. Female SD rats (n = 24) were fed a control diet (n = 8), EHOC-supplemented diet, or a positive control diet (Shengruzhi) from day 10 of pregnancy to day 10 of lactation. Maternal serum, mammary gland (day 10 of lactation), milk, and pup weight (daily) were collected for analysis. Results showed that the EHOC diet obviously elevated daily milk yield and pup weight compared to the control group (P < .05). The EHOC diet was found to increase the concentration of prolactin (PRL), progesterone (P), estradiol (E2), and growth hormone (GH) significantly in the circulation and mammary gland. Mammary glands of EHOC-treated dams showed clear lobuloalveolar development and proliferation of myoepithelial cells, but no striking variations were observed among the groups. Furthermore, the nutrition content and immune globulin concentration in the milk of EHOC-supplemented dams were higher than those of the control group, especially the cholesterol, glucose, and IgG were higher by 44.98% (P < .001), 42.76% (P < .01), and 42.23% (P < .01), respectively. In conclusion, this article demonstrates that EHOC administration has beneficial effects on milk production in the dams and on performance of the dam and pup. These results indicate that EHOC could be explored as a potentially lactogenic nutriment for lactating women.


    Rubiyatno Rubiyatno


    Abstract This study aims at delivering game models for especially top grade elementary school students to build character, cooperation, responsibility and honesty that are ready to use. The teachers are expected to use this game model as one of integrated character value instructional forms that is appropriate and effective through enjoyable playing activities.This educational research and development (R & D was conducted by adapting R & D steps consisting of: (1 collecting information and information analysis, (2 developing initial product, (3 expert validation and revision, (4 preliminary field test and revision, (5 main field test and revision, and (6 making the final product. The preliminary field test was conducted to 14 students year 5 of SD.N.Pantaran Kulon Progo and the main field test was conducted to 40 students Class 4 and 5 of SD.N.2 Kalipetir Pengasih Kulon Progo. Data collecting instrument used were: (1 interview guide, (2 rating scale, (3 observation guide for games observation, (4 observation guide for games effectiveness, and (5 observation guide for perpetrator teachers. The data were analyzed using quantitative descriptive analysis and qualitative descriptive analysis.The result of this study is in the form of a game guidance book of integrated character building for corporation, responsibility, and honesty in the form of physical activities for upper grade elementary school students, consisting of six games: (1 blast fishing game, (2 ball war game, (3 shoot the ball to the hula hoop game, (4 my goal and basket game, (5 volley throw and catch, and (6 touching ball to the body game. As a conclusion, the game models are very good and effective to transfer character value, corporation, responsibility, and honesty Keywords: model of learning, character and elemantary students.


    Nyoman Wijana


    Full Text Available Tujuan penelitian ini adalah untuk mengetahui peranan intervensi ergonomi dalam pembelajaran sains untuk menurunkan keluhan muskuloskeletal siswa SD. Jenis penelitian ini termasuk jenis penelitian quasi eksperimental dengan rancangan randomized pre-test and post-test control group design. Pada kelompok kontrol pembelajarannya dengan cara konvensional (tanpa intervensi ergonomi dan kelompok eksperimen dengan intervensi ergonomi. Intervensi ergonomi dalam pembelajaran sains mengacu pada pendekatan ergonomi (PE yakni gabungan antara SHIP dan TTG. Implementasi dari hal ini adalah melakukan perbaikan dan atau penataan terhadap instrumental input, environmental input dan porcess, sedangkan untuk di kelompok kontrol tidak dilakukan intervensi ergonomi, di mana kondisi instrumental input, environmental input dan process berlangsung secara konvensional. Pengambilan sampel dilakukan secara random. Analisis data dilakukan dengan menggunakan uji Mann-Whitney dengan taraf signifikansi 5 %. Simpulan dari hasil penelitian ini adalah (1 intervensi ergonomi dapat menurunkan keluhan muskuloskeletal siswa SD  (p < 0,05; (2 Hasil pengukuran dengan nordic body map pada kelompok kontrol terjadi keluhan pada otot pinggang (86,1%, otot pantat (86,1%, otot punggung (84,8%, otot lengan atas kiri (78,8%, otot lengan atas kanan (67,9%, otot siku kanan (78,2%, otot siku kiri (74,6%, paha kanan (76,9%, paha kiri (75,7%, otot betis kanan  (66,1%, otot betis kiri (64,2%, otot pergelangan kaki kanan (67,3%, dan otot pergelangan kaki kiri (65,5%. Dengan demikian dapat disarankan bahwa intervensi ergonomi dalam pembelajaran dengan menggunakan PE sebaiknya diterapkan dalam pembelajaran sains di SD karena telah terbukti dapat menurunkan keluhan muskuloskeletal.[MEDICINA 2009;40:11-20].  

  19. Effects of 50 and 100 mg desvenlafaxine versus placebo on sexual function in patients with major depressive disorder: a meta-analysis.

    Clayton, Anita H; Hwang, Eunhee; Kornstein, Susan G; Tourian, Karen A; Cheng, Ru-fong; Abraham, Lucy; Mele, Linda; Boucher, Matthieu


    The primary objective of this post-hoc analysis was to evaluate the effect of short-term treatment with desvenlafaxine versus placebo on sexual dysfunction (SD), assessed from Arizona Sexual Experiences Scale scores, in adult outpatients with major depressive disorder. Data from three randomized, double-blind, placebo-controlled trials of 50 or 100 mg/day desvenlafaxine for major depressive disorder were pooled. SD status, determined from Arizona Sexual Experiences Scale scores, was assessed at baseline and week 8, last observation carried forward. Subgroup analyses addressed the effects of sex, baseline SD, and antidepressant response. At week 8, last observation carried forward (n=1562), SD rates were 54, 47, and 49% for 50 mg/day desvenlafaxine, 100 mg/day desvenlafaxine, and placebo, respectively [adjusted odds ratios (95% confidence interval) vs. placebo: 1.205 (0.928, 1.564) and 1.129 (0.795, 1.604), respectively]. The treatment by baseline SD interaction approached statistical significance (P=0.0663), mainly driven by poorer scores for desvenlafaxine versus placebo in the 100 mg group. Treatment by sex interactions were not statistically significant. Small but statistically significant treatment by sex interactions were observed for sex drive (P=0.0011) and ease of erection/lubrication (P=0.0151). Although there was no overall effect of desvenlafaxine on SD, a treatment by baseline SD interaction was suggested for 100 mg desvenlafaxine.

  20. Avaliação de contaminação por mercúrio em Descoberto, MG Evaluation of mercury contamination in Descoberto, MG

    Ana Amélia Paulino Tinôco


    Full Text Available O mercúrio, elemento químico considerado não essencial a qualquer processo metabólico, é facilmente acumulado na maioria dos organismos. Ocorre naturalmente em formas orgânicas e inorgânicas, nos estados sólido, dissolvido e gasoso. Seu ciclo biogeoquímico envolve processos que ocorrem no solo, na água e na atmosfera. Em 2002, descobriu-se mercúrio elementar na zona rural do município de Descoberto, Minas Gerais, onde moram cerca de 70 famílias, e sua origem parece estar associada à exploração de ouro, que existiu na região no século 19. Neste trabalho, foram escolhidas três áreas para identificar possível contaminação da água, solo, sedimento e peixes por mercúrio, bem como para estabelecer valores de referência local e contraprova de resultados obtidos anteriormente. Verificaram-se elevadas concentrações no solo (0,26 a 0,55, sedimentos (0,13 a 0,61 e água (Mercury is a chemical element considered unessential to any metabolic process; however, it is easily accumulated in most organisms. It is naturally found in both organic and inorganic forms in solid, liquid and vapor states. Its biogeochemical cycle involves processes occurring in the soil, water and the atmosphere. In 2002, elementary mercury was found in the city of Descoberto, Minas Gerais, Brazil, where 70 families live, and its origin may be related to gold exploration that happened in this region in the 19th century. In this work, three areas were chosen to identify a possible mercury contamination of water, soil, sediment and fish samples and to establish local reference values and counter-evidence of the data previously obtained. Based on the results, high mercury concentrations in soil (0.26 to 0.55, sediments (0.13 to 0.61 and water (< 0.2 to 2,10 µg.L-1 were verified.

  1. Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats.

    Zhang, Kexia; Zhang, Meiyu; Liu, Ziying; Zhang, Yuanyuan; Gu, Liqiang; Hu, Gaosheng; Chen, Xiaohui; Jia, Jingming


    Quercetin (QT) is a natural flavonoid with various biological activities and pharmacological actions. However, the bioavailability of QT is relatively low due to its low solubility which severely limits its use. In this study, we intended to improve the bioavailability of QT by preparing quercetin-phospholipid complex (QT-PC) and investigate the protective effect of QT-PC against carbon tetrachloride (CCl4) induced acute liver damage in Sprague-Dawley (SD) rats. The physicochemical properties of QT-PC were characterized in terms of infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRPD) and water/n-octanol solubility. FTIR, DSC and XRPD data confirmed the formation of QT-PC. The water solubility of QT was improved significantly in the prepared complex, indicating its increased hydrophilicity. Oral bioavailability of QT and QT-PC was evaluated in SD rats, and the plasma QT was estimated by HPLC-MS. QT-PC exhibited higher Cmax (1.58±0.11 vs. 0.67±0.08μg/mL), increased AUC0-∞ (8.60±1.25 vs. 2.41±0.51mg/Lh) and t1/2z (7.76±1.09 vs. 4.81±0.87h) when compared to free QT. The greater absorption of QT-PC group suggested the improved bioavailability. Moreover, biochemical changes and histopathological observations revealed that QT-PC provided better protection to rat liver than free QT at the same dose. Thus, phospholipid complexation might be one of the suitable approaches to improve the oral bioavailability of QT and obtain better protective effects against CCl4 induced acute liver damage in SD rats than free QT at the same dose level.

  2. The Effect of Propiconazole and Protective Effects of Selenium Gene Expression Profile of Caspase 9 in the Testicular Tissue of Male Sprague Dawley (SD Rats

    S Rashidi pouya


    Full Text Available Background & aim: Conazoles including imidazoles or triazoles are anti- fungal agents widely used to prevent fungal growth and their infections. Propiconazole placed in this group is a systemic fungicide used widely for detoxification of cereal seeds especially rice in Iran and other countries. This fungicide were designed to inhibit a specific cytochrome P450, CYP51 (lanosterol-14-α- demethylase, a critical step in the biosynthesis of ergosterol, a steroid required for the formation of the fungal cell wall. In the present experimental study, the effect of propiconazole on Caspase 9 gene expression profile as an initiator of apoptotic process and protective effect of selenium were investigated. Methods: Forty SD rats were divided into 10 groups of 4,  including : control , sham1 (solvent of propiconazole, distilled water, sham 2 (solvent of selenium, normal saline and 1 group received 0.5 mg/kg selenium ,3 groups received propiconazole in doses of 10,50,75  mg/kg and 3 groups received propiconazole in doses of 10,50,75 mg/kg propiconazole with 0.5 mg/kg of selenium. Injections were intrapritoneal for two weeks in alternate days. Then, using RT-PCR and Total Lab program gene expression of caspase-9 testicular of all groups were studied. Data were analyzed using descriptive statistics. Results:  A significant increase of caspase 9 expression were observed among all experimental groups compared to control and sham groups. These findings indicated that 0.5 mg/kg selenium is not a suitable dose to create protection in this experimental study.  Conclusion: The significant increase in Caspase 9 gene expression profile observed in all experimental groups as compared to control suggests activation of apoptosis and inefficacy of selenium to protect the testis against induced damages.

  3. SD OCT Features of Macula and Silicon Oil–Retinal Interface in Eyes Status Post Vitrectomy for RRD

    Manish Nagpal; Navneet Mehrotra; Rituraj Videkar; Rajen Mehta


    Aim: To objectively document findings at the Silicon oil-Retinal interface, macular status and tamponade effect in Silicon Oil (SO) filled eyes using SD OCT. Methods: 104 eyes of 104 patients underwent SD OCT examination, horizontal and vertical macular scans, in silicone oil filled eyes which underwent silicone oil injection post vitrectomy for rhegmatogenous retinal detachment. Findings were divided into 3 Groups; Group A: Findings at silicon oil retinal interface, Group B: Macular patholog...

  4. An experimental model of chronic renal allograft rejection in SD-Wistar rats%改进SD-Wistar大鼠肾移植慢性排斥模型的造模方法

    余鹏程; 赵明; 刘永光; 郭颖; 李民; 肖宗宇; 胡孔和; 黄进军; 辛军; 吴志强


    背景:国际上常用的肾移植慢性排斥模型是 Fisher→Lewis 大鼠肾移植模型等,但这些模型在国内均较难以获得并且价格昂贵,大规模使用受到了一定的限制。目的:探索建立SD→Wistar大鼠肾移植慢性排斥模型的新方法。方法:将56对SD→Wistar大鼠作左肾原位移植,受体自身右肾保留作为内对照。23只成功移植的受体大鼠随机分为模型组(n=15)和对照组(n=8)。模型组大鼠在移植后给予10 d的小剂量环孢素微乳化剂[2 mg/(kg·d),腹腔注射],对照组大鼠未给予免疫抑制治疗。结果与结论:对照组大鼠所有移植肾均在4周内出现不可逆的急性排斥反应,移植肾坏死;模型组大鼠移植后4,8,12周时均可见移植肾中出现中等度的炎症细胞浸润,在移植后12周内出现典型的慢性排斥组织病理学改变,其Banff总分随移植后时间的延长而升高。2组大鼠所有受体的自身右肾均没有出现组织病理学改变。模型组大鼠移植后第4天环孢素浓度谷值为(153.2±17.1)μg/L。说明通过给予肾移植的SD→Wistar大鼠受体10 d小剂量的环孢素微乳化制剂(2 mg/kg),可使移植肾出现中等度的炎症细胞浸润并于12周内形成慢性排斥的典型组织病理学改变,可作为研究肾移植慢性排斥的动物模型。%BACKGROUND:Fisher-Lewis rat kidney transplant models are the international common chronic renal alograft rejection models, but their application is greatly limited because of difficulty in model preparation and high costs. OBJECTIVE:To explore a new method of establishing SD-Wistar rat models of chronic renal alograft rejection. METHODS: Fifty-six pairs of SD-Wistar rats were subjected to left kidney orthotopic transplantation. The right kidneys of the recipients were intact and used as internal controls. 23 rat recipients were randomly divided into model group (n=15) and control group (n=8). The rats in the

  5. From $^{27}$Mg to ${33}$Mg transition to the "Island of inversion"

    Yordanov, Deyan

    Since introduced in nuclear physics, the concept of shell structure and magic numbers has governed our understanding of nuclear matter in atomic nuclei close to stability. Nuclear species with a magic number of protons and/or neutrons are known to be more stable and close to spherical in shape. Experimental studies of 30Ne, 31Na and 32Mg, systems with a closed neutron sd shell (N=20), provide evidence for a ground-state deformation in these nuclei. The observed phenomenon is understood as an inversion of the normal spherical ground-state configuration, expected according to the traditional shell model, with deformed states governed by particle-hole excitations over the N=20 shell gap. The properties of nuclei in this Island of inversion are of particular importance for the theoretical modeling of the region. The present doctoral dissertation reports on the first determination of the nuclear ground-state spins and magnetic moments of 31,33Mg, obtained by means of laser spectroscopy in combination with nuclear...


    Muhamad Ahyar Rasidi


    Full Text Available Penelitian ini bertujuan untuk menentukan faktor-faktor kesulitan guru pada pembelajaran tematik integratif di SD Kota Mataram. Penelitian ini merupakan penelitian survey dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh  guru SD yang ada di Kota Mataram. Pengambilan sampel dilakukan secara multistage random sampling dan dianalisis dengan analisis faktor eksploratori. Hasil penelitian menunjukkan bahwa ada empat faktor kesulitan guru pada perencanaan pembelajaran yaitu: (1 penjabaran materi yang relevan dengan konten pembelajaran, (2 pemilihan metode dan media berorientasi lingkungan, (3 penyusunan indikator, dan (4 penjabaran materi yang relevan dengan tema. Pada aspek pelaksanaan, terdapat tiga faktor yaitu: (1 penguasaan konsep dalam pembelajaran saintifik yang interaktif, (2 pemanfaatan media dalam menciptakan karya, dan (3 penguasaan keterampilan apersepsi. Pada pengelolaan kelas, faktor-faktor yang mempengaruhi adalah: (1 penataan kelas yang variatif dan edukatif, (2 pengkordinasian belajar sesuai konteks pembelajaran, dan (3 pengkoordinasian kelas dengan regulasi simpel dan terukur. Ditemukan tiga faktor pada penilaian pembelajaran yaitu: (1 pengembangan perangkat penilaian terstandar, (2 pendeskripsian hasil belajar secara kualitatif dan kuantitatif, dan (3 pemilihan instrumen penilaian sikap, pengetahuan, dan keterampilan. Kata Kunci: faktor-faktor, kesulitan guru, pembelajaran tematik integratif   THE FACTORS THE TEACHERS’ DIFFICULTIES IN THE IMPLEMENTATION OF AN INTEGRATED THEMATIC TEACHING IN ELEMENTARY SCHOOLS IN MATARAM Abstract This study aims to determine the factors the teachers’ difficulties in the implementation of an integrated thematic teaching in elementary schools in Mataram. This study is a survey with the quantitative approach. The population in this study was all primary school teachers in the city of Mataram. The sampling was done by multistage random sampling and were analyzed using the

  7. Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range

    Miraftabi, Arezoo; Amini, Navid; Morales, Esteban; Henry, Sharon; Yu, Fei; Afifi, Abdolmonem; Coleman, Anne L.; Caprioli, Joseph; Nouri-Mahdavi, Kouros


    Purpose We tested the hypothesis that the macular ganglion cell layer (GCL) thickness demonstrates a stronger structure-function (SF) relationship and extends the useful range of macular measurements compared with combined macular inner layer or full thickness. Methods Ninety-eight glaucomatous eyes and eight normal eyes with macular spectral domain optical coherence tomography (SD-OCT) volume scans and 10-2 visual fields were enrolled. Inner plexiform layer (IPL), GCL, macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and full thickness (FT) measurements were calculated for 8 × 8 arrays of 3° superpixels. Main outcome measures were local structure-function relationships between macular superpixels and corresponding sensitivities on 10-2 fields after adjusting for ganglion cell displacement, dynamic range of measurements, and the change point (total deviation value where macular parameters reached measurement floor). Results Median (interquartile range [IQR]) mean deviation was −7.2 (−11.6 to −3.2) dB in glaucoma eyes. Strength of SF relationships was highest for GCIPL, GCL, GCC, and IPL (ρ = 0.635, 0.627, 0.621, and 0.577, respectively; P ≤ 0.046 for comparisons against GCIPL). Highest SF correlations coincided with the peak of GCL thickness, where the dynamic range was widest for FT (81.1 μm), followed by GCC (65.7 μm), GCIPL (54.9 μm), GCL (35.2 μm), mRNFL (27.5 μm), and IPL (20.9 μm). Change points were similar for all macular parameters (−7.8 to −8.9 dB). Conclusions GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range. Measurement of GCL did not extend the range of useful structural measurements. Measuring GCL does not provide any advantage for detection of progression with current SD-OCT technology. PMID:27623336

  8. Intravenous Toxicity Study of Water-soluble Ginseng Pharmacopuncture in SD Rats

    Jun-Sang Yu


    Full Text Available Objectives: Radix Ginseng has been used for thousands of years to treat a wide variety of diseases. Radix ginseng has also been used as a traditional medicine for boosting Qi energy and tonifying the spleen and lungs. Traditionally, its effect could be obtained orally. Nowadays, a new method, the injection of herbal medicine, is being used. This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginseng pharmacopuncture (WSGP in Sprague-Dawley (SD rats. Methods: All experiments were carried out at Biotoxtech, an institute authorized to perform non-clinical studies under the regulation of Good Laboratory Practice (GLP. At the age of six weeks, 40 SD rats, 20 male rats and 20 female rats, were allocated into one of 4 groups according to the dosages they would receive. The WSGP was prepared in the Korean Pharmacopuncture Institute under the regulation of Korea-Good Manufacturing Practice (K-GMP. Dosages of WSGP were 0.1, 0.5 and 1.0 mL/animal for the experimental groups, and normal saline was administered to the control group. The rat's general conditions and body weights, the results of their hematological and biochemistry tests, and their necropsy and histopathological findings were investigated to identify the toxicological effect of WSGP injected intravenously. The effect was examined for 14 days after the WSGP injection. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech. Results: No deaths were found in this single-dose toxicity test on the intravenous injection of WSGP, and no significant changes in the rat's general conditions and body weights, the results on their hematological and biochemistry test, and their necropsy findings were observed during the test. The local area of the injection site showed minial change. The lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results indicate that WSGP is safe at dosages up to


    Ayu Indah Hapsari


    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Elementary school student are the group of student that potentialy having problem with nutrition due to their eating patern and development status. The cases of malnutrition in Ubud is still highly noted even if Ubud is kown as well-developed subdistrict. The aimed of the study is to descript the nutritional status and other factors related to among the students of SD Negeri 3 Peliatan, Subdistrict Ubud, Gianyar. This study was done on August 19th 2011 until August 20th 2011 and the study design was a cross-sectional. Subjects were the grade 5th and 6th students with a total of 70 student, were chosen by quota sampling technique. Every subject was asked to administer questionnaire, to get the informaton on characteristic, eating pattern and breakfast habit. Antropometric measurements were done to gain the nutritional status of sampel. History of low birth weight was collected from the parents through administering self-administered questionnaires. The data was analysed descriptively. Result showed that subjects tend to have high malnutrition cases, in whom 25.7% were undernutrition and 24.3% were overnutrition 24.3%. Majority of subjects who have good nutritional status were those who admitted to have balanced eating pattern and breakfast habit. In addition, subjects with good nutrition status tended to have good academic scores and those with history of low birth weight seemed to have good and over nutritional status. As the students of SD Negeri 3 Peliatan seemed to have remarkable problem of malnutrition, it is suggested to inform their parents regarding the best eating pattern and to emphasize the importance of berakfast habit to achieve and maintain the good nutritional status for their children. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso

  10. Proses Berpikir Siswa SD dalam Melakukan Estimasi Masalah Berhitung Berdasarkan Jenis Kelamin

    Muh. Rizal


    Full Text Available Abstract: The Thinking Process of Primary-school Students of Different Sexes in Estimating Arithmetic Problems. This case study is intended to explore the thinking process of the fifth-year students of different sexes in estimating arithmetic problems. Two students, one male and one female, belonging to the high achievers in a mathematics test were selected for the study and then interviewed, assigned to solve arithmetic problems, and finally asked to think aloud their thinking process. The study reveals that the thinking process of both the male and female subjects is in the form of accommodation as they ap­proached the arithmetic problems by repeatedly reading the tasks. Though employing the same thinking process, in the planning stage, the male subject made use of rounding and compatible number strategies, whereas the female one used only rounding strategy. In implementing the plan, the male subject em­ployed mental counting through assimilation, but the female one used algorithm through accommoda­tion. In the evaluating stage, the male subject traced back his work through mental counting, while the female one utilized reverse operations. Abstrak: Proses Berpikir Siswa SD dalam Melakukan Estimasi Masalah Berhitung Berdasarkan Jenis Kelamin. Penelitian ini ingin mendeskripsikan proses berpikir siswa laki-laki dan perempuan yang berkemampuan matematika tinggi dalam melakukan estimasi. Penelitian dilakukan di kelas V SD, dengan subjek satu siswa laki-laki dan satu siswa perempuan yang memiliki skor 75 ke atas dalam tes kemampuan matematika. Data dikumpulkan dengan wawancara, pemberian tes dan think aloud. Analisis dilakukan dengan menelaah seluruh data, reduksi data, pengolompokan data, kategorisasi, pengkodean, dan pemeriksaan kredibilitas data dengan triangulasi waktu. Hasil penelitian menunjukkan bahwa proses berpikir keduanya adalah akomodasi. Dalam membuat rencana, laki-laki menggunakan rounding dan compatible number strategy, sedangkan


    Tresna Adhi K


    Full Text Available Iodine deficiency disorder (IDD is the most single common cause of preventable mental retardation and brain damage in the world. It decreases child survival, causes goiters, and impairs growth and development. Apuan Village, Bangli Regency is categorized as endemic areas (TGR=20,3% according to the definition from Health Office reports of Bali Province in 2008. One of the approaches that might be worth considering in alleviating the problem is the empowerment of elementary school children in an effort to increase the consumption of iodized salt in household. This approach aimed at empowering children to provide information to their parents on iodized salt consumption. Community services activities were conducted from December 16 to 21 October 2010 in SD 1 and SD 3 Apuan involving 62 elementary school children. The main activities were the provision of knowledge and guidance to elementary school children about the benefits of iodized salt. The first phase of the activities consists of examining the level of iodine in salt. This phase was then followed by giving the students a pre-test prior to the guidance and a post-test after the guidance for measuring the level of improvement on knowledge of elementary school children about iodized salt. The second phase was conducted one week after the first phase by measuring the level of iodine in the household salt of the same respondents. Data were analyzed using descriptive and analytical by computer program. Results pre-test and post-tests showed an increase in the knowledge for good knowledge category (0% to 31%, and moderate knowledge category (3.2% to 40.3% and while a decrease in the limited knowledge category (96.8% to 9.7%. Statistical analysis showed significant differences (p <0.05. Test results that contain iodine salt showed increased percentage of 72.6% in the first phase to 96.7% in the second phase. It can be concluded that elementary school children might become a good initiator to improve


    Budi Wijayarto


    Full Text Available Penelitian ini bertujuan untuk mengetahui perbedaan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan model pendidikan konvensional. Subjek dalam penelitian ini adalah siswa berusia 9-13 tahun, laki-laki dan perempuan. Teknik pengambilan data menggunakan metode angket. Adapun angket yang digunakan adalah skala kompetensi sosial yang disusun oleh peneliti sendiri dengan mengacu pada aspek-aspek yang dikemukakan oleh Frey & Bos (2012 hingga dihasilkan aitem sebanyak 24 aitem. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows, untuk menguji apakah terdapat perbe-daan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan konvensional. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows dengan Teknik Independent Samples T-tes. Hasil penelitian menunjukkan bahwa terdapat perbedaan kompetensi Sosial antara siswa homeschooling dengan siswa SD reguler, dimana siswa homeschooling lebih tinggi kompetensi sosialnya daripada siswa sekolah reguler. _________________________________________________________________________________________________________________________________________________ COMPARISON SOCIAL COMPETENCE BETWEEN HOMESCHOOLERS IN SOLO WITH REGULAR ELEMENTARY STUDENTS IN SD MUHAMMADIYAH 1, SOLO ABSTRACT The purpose of this research is to know the difference social competence between children that following homeshooling education model and regular education model.  The subjects in this research were childrens with 9-13 of age, boys and/or girls. The data was collected using social competence scale that was made by writer also the items from aspects that was publicated by Frey and Bos (2012. The data was tested by using SPSS 16.0 for Windows, to know are there any differences of social competence between children that following homeschooling education model and

  13. Clinical, hematological and genetic data of a cohort of children with hemoglobin SD

    Paulo do Val Rezende

    Full Text Available ABSTRACT INTRODUCTION: The hemoglobin FSD is very uncommon in newborn screening programs for sickle cell disease. In the program of Minas Gerais, Brazil, the clinical course of children with hemoglobin SD was observed to be heterogeneous. The objective of this study was to estimate the incidence (1999-2012 and to describe the natural history of a cohort of newborns with hemoglobin SD. METHODS: Isoelectric focusing was the primary method used in newborn screening. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to identify mutant alleles and for haplotyping. Gap-polymerase chain reaction was used to detect alpha-thalassemia. RESULTS: Eleven cases of hemoglobin S/D-Punjab and eight of Hb S-Korle Bu were detected. Other variants with hemoglobin D mobility were not identified. All hemoglobin D-Punjab and hemoglobin Korle Bu alleles were associated with haplotype I. Among the children with hemoglobin S/D-Punjab, there were four with the ßS CAR haplotype, six with the Benin haplotype, and one atypical. Results of laboratory tests for hemoglobin S/D-Punjab and hemoglobin S-Korle Bu were: hemoglobin 8.0 and 12.3 g/dL (p-value <0.001, leukocyte count 13.9 × 109/L and 10.5 × 109/L (p-value = 0.003, reticulocytes 7.5% and 1.0% (p-value <0.001, hemoglobin F concentration 16.1% and 6.9% (p-value = 0.001 and oxygen saturation 91.9% and 97% (p-value = 0.002, respectively. Only hemoglobin S/D-Punjab children had acute pain crises and needed blood transfusions or hydroxyurea. Those with the Benin ßS haplotype had higher total hemoglobin and hemoglobin F concentrations compared to the CAR haplotype. Transcranial Doppler was normal in all children. CONCLUSION: The clinical course and blood cell counts of children with hemoglobin S/D-Punjab were very similar to those of hemoglobin SS children. In contrast, children with hemoglobin S-Korle Bu had clinical course and blood cell counts like children with the sickle

  14. Effects of Danshen Injection on the Malignant Obstructive Jaundice in the SD Rat Model


    To observe the effects of Danshen on the growth of hepatocellular carcinoma in the SD rats, a model of malignant obstructive jaundice was established by inoculation of transplanted tumor into the hepatic portal with the walker-256 hepatocarcine line, which resulted in the obstruction by the infiltration and metastasis of hepatocellular carcinoma. SD rats were divided into 4 groups: the rats were treated by 0.9 % NS (n=24, control group), inosine+vitamin C (n=40, InV group), Danshen (n=40, DS group) and 5-FU (n=40, 5-FU group), respectively. The liver function, morphological changes and the expressions of PCNA, VEGF and ICAM-1 in carcinoma foci, peri-carcinoma tissues,adjacent lobe (left-internal lobe) and lung tissues were observed after the treatment with the 4 agents.Our results showed that the protective effect of Danshen on liver function was significantly better than that of NS and 5-FU (P<0.01). No significant difference in protective effect was observed between DS group and InV group (P>0.05). Danshen also provided protective effect on the morphological damage of liver caused by obstructive jaundice. The rates of carcinoma-inhibition and metastasis inhibition were significantly higher than those of NS and inosine+vitamin C (P<0.01). No significant difference in this regard existed between DS group and 5-FU group (P>0.05). The expressions of PCNA,VEGF and ICAM-1 PCNA, VEGF and ICAM-1 in carcinoma foci, peri-carcinoma tissues, adjacent lobe (left-internal lobe) and lung tissues were lower than those in control group and InV group, with the differences being significant (P<0.01). No significant differences were found between DS group and 5-FU group in the expression levels of PCNA and VEGF (P>0.05) but ICAM-1 (P<0.05). It is concluded that Danshen injection not only has protective effects on liver injury caused by obstructive jaundice, but can inhibit the proliferation and growth of hepatocarcinoma,interfere with the vascularization of tumors

  15. Exploring the island of inversion with the d({sup 30}Mg,p){sup 31}Mg reaction

    Bildstein, Vinzenz


    In this thesis the results of a d({sup 30}Mg,p){sup 31}Mg experiment at REX-ISOLDE are presented. {sup 31}Mg is located directly on the border of the so-called ''Island of Inversion'', a region of the nuclear chart around {sup 32}Mg where deformed intruder states of the fp shell form the ground states of the nuclei instead of the normal spherical states of the sd shell. A recent experiment has shown the ground state of {sup 31}Mg to be a 1/2{sup +} state and indicates more than 90% intruder configuration. The question whether the low-lying excited states of {sup 31}Mg are deformed intruder states as well or rather spherical states from the sd shell, indicating shape coexistence, is still open. The d({sup 30}Mg,p) {sup 31}Mg reaction is thus a good tool to gain more insight into the nature of the Island of Inversion. In the framework of this thesis the angular distribution of protons was measured for the second excited state at 221 keV in coincidence with de-excitation {gamma}-rays. The angular distribution was compared to DWBA calculations for different transferred orbital momenta, identifying the state for the first time as an l=1 state. The experiment was performed with the new charged particle detector setup T-REX. The setup is optimized for transfer reactions with radioactive beams in inverse kinematics. T-REX was developed, built, installed, and used for this first one neutron transfer experiment in the context of this thesis. The T-REX setup consists of {delta}E-E{sub Rest} telescopes made out of position sensitive silicon detectors that cover almost 4{pi} of the solid angle and can be combined with the MINIBALL {gamma}-ray detector array. It has a large solid angle for the detection and identification of the light recoils from transfer reactions. T-REX allows in combination with the MINIBALL Germanium detector array the tagging of the excited states by their characteristic {gamma}-rays. The combination of T-REX and MINIBALL achieves an

  16. Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?

    Watanabe, Kimio; Okada, Kana; Fukabori, Ryoji; Hayashi, Yoshimitsu; Asahi, Koichi; Terawaki, Hiroyuki; Kobayashi, Kazuto; Watanabe, Tsuyoshi; Nakayama, Masaaki


    Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl compound. Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma MG levels and presence of kidney dysfunction. Therefore, the present study aims to examine whether MG is a direct causative substance for CI development. Eight-week-old male Sprague-Dawley (SD) rats were divided into two groups: control (n = 9) and MG group (n = 10; 0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests (object exploration test and radial-arm maze test) in early (4-6 months of age) and late phase (7-12 months of age). Serum MG was significantly elevated in the MG group (495.8 ± 38.1 vs. 244.8 ± 28.2 nM; p < 0.001) at the end of study. The groups did not differ in cognitive function during the course of study. No time-course differences were found in oxidative stress markers between the two groups, while, antioxidants such as glutathione peroxidase and superoxide dismutase activities were significantly increased in the MG group compared to the control. Long-term MG administration to rats with normal kidney function did not cause CI. A counter-balanced activation of the systemic anti-oxidant system may offset the toxicity of MG in this model. Pathogenetic significance of MG for CI requires further investigation.

  17. Spectrum of {gamma} rays from the decay of SD to normal states in {sup 191}Hg

    Gassmann, D.; Khoo, T.L.; Lauritsen, T. [and others


    In B.a.7. we propose that the statistical spectrum emitted from a sharp single excited state serves as a probe of pairing in excited states. A specific test of this proposal is the comparison of the spectra from even-even and odd-even nuclei. Whereas a pair gap exists in an even-even nucleus, it gets filled in an odd-even nucleus. Consequently, low-energy transitions can arise in the latter case, whereas they are calculated to be absent in the former case because very few levels exist in the cold gap region. In addition, transitions between 1.4 - 2.2 MeV, which {open_quotes}jump{close_quotes} across the gap, are predicted to have lower yield in the odd-even nuclei. Serendipitously, decay from a superdeformed state serves as a good initial excited sharp state. We extracted the spectrum pairwise-coincident with SD lines in {sup 191}Hg from Gammasphere data and compared it with the equivalent spectra from the even-even nuclei {sup 192,194}Hg. The differences that are predicted to occur are indeed observed. Thus, the data support our proposal that the reduction of pairing with thermal excitation energy can be probed with statistical decay spectra.

  18. The sdB+M Eclipsing System HW Virginis and its Circumbinary Planets

    Lee, Jae Woo; Kim, Chun-Hwey; Koch, Robert H; Lee, Chung-Uk; Kim, Ho-Il; Park, Jang-Ho


    For the very short-period sdB eclipsing binary HW Vir, we present new CCD photometry made from 2000 through 2008. In order to obtain consistency of the binary parameters, our new light curves were analyzed simultaneously with previously published radial-velocity data. The secondary star parameters of $M_2$=0.14 M$_\\odot$, $R_2$=0.18 R$_\\odot$, and $T_2$=3,084 K are consistent with those of an M6-7 main sequence star. More than 250 times of minimum light, including our 41 timings and spanning more than 24 yrs, were used for a period study. From a detailed analysis of the $O$--$C$ diagram, it emerged that the orbital period of HW Vir has varied as a combination of a downward-opening parabola and two sinusoidal variations, with cycle lengths of $P_3$=15.8 yr and $P_4$=9.1 yr and semi-amplitudes of $K_3$=77 s and $K_4$=23 s, respectively. The continuous period decrease with a rate of $-8.28\\times10^{-9}$ d yr$^{-1}$ may be produced by angular momentum loss due to magnetic stellar wind braking but not by gravitati...


    Yuentie Sova Puspidalia


    Full Text Available Abstract: The ultimate goal of Indonesian teaching is to help learners able to integrate themselves into the society successfully. This aim is in line with the development of science and technology in the globalization era, in which the role of the Indonesian language as a mean of personal development is inevitably challenged by the rapid changes and the need of international languages. For this reason, it is worried that learners face any negative wash back of the existence of International language, in instance, the lost of their own identity. To this end, the role of Indonesian teaching is getting more and more obviously important. In reality, however, the Indonesian teaching is generally assumed as the easiest subject if it is compared with other subjects. As a result of this case, learners pretend not to learn Indonesian seriously. Ironically, many students get low grade although the Indonesian lesson is seen easily to learn. In fact, elementary school (SD/MI is regarded as basis for the formation of the noble values of the nation. The study had identified several sources of problems in learning Indonesian both from the educators or learners. Besides, it was revealed that the result of learning was affected by some aspects, such as the goals, materials, methods, school facilities and infrastructure.

  20. Spectral analysis of four multi mode pulsating sdB stars

    Heber, U; Werner, K


    Four members of the new class of pulsating sdB stars are analysed from Keck HIRES spectra using NLTE and LTE model atmospheres. Atmospheric parameters (Teff, log g, log(He/H)), metal abundances and rotational velocities are determined. Balmer line fitting is found to be consistent with the helium ionization equilibrium for PG1605+072 but not so for PG1219+534 indicating that systematic errors in the model atmosphere analysis of the latter have been underestimated previously. All stars are found to be helium deficient probably due to diffusion. The metals are also depleted with the notable exception of iron which is solar to within error limits in all four stars, confirming predictions from diffusion calculations of Charpinet et al. (1997). While three of them are slow rotator's (vsini < 10km/s), PG1605+072 displays considerable rotation (vsini = 39km/s, P<8.7h) and is predicted to evolve into an unusually fast rotating white dwarf. This nicely confirms a prediction by Kawaler (1999) who deduced a rotati...


    Aprilia Eki Saputri


    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan pelaksanaan pembelajaran sains SD di SLB-A Yaketunis. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian etnografi kelas. Data dianalisis menggunakan analisis data Miles dan Huberman yaitu: reduksi, penyajian, dan verifikasi data. Hasil penelitian menunjukkan bahwa pembelajaran sains di SLB-A Yaketunis diawali dengan analisis kebutuhan siswa. Materi pembelajaran yang dapat diwujudkan dalam bentuk konkrit dan media pembelajaran tersedia atau dapat disediakan guru, maka indera perabaanlah yang dimaksimalkan oleh guru. Sedangkan materi pembelajaran yang tidak dapat diwujudkan dalam bentuk konkrit, hanya diampaikan dengan memanfaatkan komunikasi verbal yang bersifat kontekstual. Budaya kelas di dalam pembelajaran sains di SLB-A Yaketunis adalah menumbuhkan rasa ingin tahu siswa terhadap fenomena-fenomena yang ada di alam semesta, pemanfaatan indera perabaan, dan pendengaran siswa di dalam belajar sains. Budaya tersebut dikembangkan dan dimanfaatkan sepanjang pembelajaran sains agar siswa menguasai keterampilan proses sains dasar (observasi, klasifikasi, mengukur, komunikasi, prediksi, dan inferensi untuk mempelajari fakta, konsep, prinsip, dan teori dalam mata pelajaran sains. Kata kunci: pembelajaran sains dan siswa tunanetra.

  2. The effect of childbirth on carcinogenesis of DMBA-induced breast cancer in female SD rats.

    Zhao, Ji-An; Chen, Jin-Jun; Ju, Ying-Chao; Wu, Jian-Hua; Geng, Cui-Zhi; Yang, Hui-Chai


    Many epidemiologic and clinical studies have indicated that the frequency of breast cancer was lower in parous women than in nulliparous women. Moreover, the incidence of breast cancer has been reported to be lower in women with early childbirth than in women with late childbirth. To verify the effect of childbirth and the age at first childbirth on carcinogenesis and progression of breast cancer, we induced breast cancer by 7,12-dimethylbenanthracene (DMBA) in 120 female Sprague-Dawley (SD) rats, and divided them into control or experimental (DMBA-treated) nulliparous, early childbirth, and late childbirth groups to observe the incidence, latency, and size of breast cancer. Argyrophilic nucleolar organizer regions (AgNOR) count and the expression of C-erbB-2, proliferating cell nuclear antigen (PCNA), Ki-67, and minichromosome maintenance protein 2 (MCM2) in breast cancer tissues were detected by immunohistochemistry. The breast cancer incidences were 95.0%, 16.7%, and 58.8% in the experimental nulliparous, early childbirth, and late childbirth groups, respectively (all P induced breast cancer.

  3. Age-related Histological Findings in the Pineal Gland of Crl:CD(SD) Rats.

    Tomonari, Yuki; Sato, Junko; Wako, Yumi; Tsuchitani, Minoru


    To provide background data as the pathologic basis, the pineal glands of 190 male and 193 female Crl:CD(SD) rats at ages of 0-7, 51-58, 70-85 and 111 weeks were examined histologically in this study. Mineralization and fibrosis were common findings in the aged rats, whereas they were rarely found in the young ones; mineralization was present in 7, 44, 67 and 79% of males and in 0, 32, 67 and 79% in females, and fibrosis was present in 0, 29, 48 and 44% of males and 0, 18, 40 and 35% of females at ages of 0-7, 51-58, 70-85 and 111 weeks, respectively. Striated muscle fiber appeared regularly in the fibrosis region from 51-58 weeks of age when fibrosis increased, while the origin of this fiber remained unclear. Vacuolation of pineal cells also increased with age in both sexes, though the total incidence was low. There was a low incidence of lymphocytic infiltration in both sexes, but this was not related to age.


    Hasuenah Dumeedae


    Full Text Available Penelitian ini bertujuan untuk mengungkap pelaksanaan proses pembelajaran bahasa Melayu di SD Amanasak Kabupaten Muang Pattani Thailand Selatan, meliputi pendekatan, metode, strategi tek-nik dan media pembelajaran, interaksi guru dan siswa, serta peran guru, siswa, dan materi. Penelitian ini menggunakan metode penelitian kualitatif. Subjek adalah guru, para siswa dan wakil kepala seko-lah, objek adalah pelaksanaan pembelajaran bahasa Melayu di lembaga tersebut. Teknik pengumpulan data adalah observasi berpartisipasi, wawancara, dan studi dokumentasi. Hasil penelitian ini menun-jukkan bahwa pendekatan, metode, strategi dan teknik pembelajaran yang digunakan cukup membuat siswa antusias untuk mempelajari bahasa Melayu. Media pembelajaran yang digunakan dalam labora-torium telah digunakan dengan maksimal, namun tidak sering digunakan. Interaksi guru dan siswa berjalan dengan baik, meskipun belum seluruhnya menggunakan bahasa Melayu dan bahkan penggu-naan bahasa Thai masih lebih banyak daripada bahasa Melayu. Guru telah menjalani tugasnya sebagai fasilitator, perencana, dan pengontrol dengan baik. Siswa telah diberi kesempatan untuk mencari sum-ber belajar tambahan, sementara materi yang ada cukup membuat siswa bersemangat mengikuti pem-belajaran. Pengelolaan kelas dalam belajar mengajar sudah meningkatkan hasil pembelajaran dengan efektif, dan efisien. Evaluasi proses pelajaran menggunakan tes berbahasa dari membaca, berbicara, menyimak dan menulis. Alat evaluasi sudah sesuai dengan rencana pelaksanaan pembelajaran dan kemampuan siswa yang berhubungan dengan aspek kognitif, sosial, afektif, dan personal. Pengukur ini sudah mencakup materi dan keterampilan berbahasa siswa. Kata kunci: bahasa Melayu, pelaksanaan pembelajaran


    Meina Febriani


    Full Text Available Salah satu cara membelajarkan muatan budaya dan ilmu pengetahuan yakni dengan kegiatan apresiasi dongeng. Dongeng sebagai salah satu karya sastra memiliki potensi untuk menghela muatan Content Language Integrated Learning (CLIL dan ungkapan Jawa. Setelah mempelajari buku-buku apresiasi dongeng yang sudah ada, ditemukan fakta bahwa buku-buku tersebut masih belum sesuai harapan, baik dari aspek isi, penyajian, bahasa dan keterbacaan, maupun grafika. Relevan dengan situasi tersebut, diperlukan buku pengayaan apresiasi dongeng yang bermuatan CLIL yang sesuai bagi peserta didik SD kelas 3, baik dari aspek isi, penyajian, bahasa dan keterbacaan, maupun grafika. Metode yang digunakan dalam penelitian ini adalah Research andDevelopment (penelitian dan pengembangan dari Borg dan Gall. One way to learn culture and science that is the fabled appreciation activities. Fairy tale as one of the literary works have the potential to haul cargo Content Language Integrated Learning (CLIL and Java expression. After studying the books offairy tale sexisting appreciation, it was found that these books is not as expected, both from the aspect of content, presentation, language and readability, and graphics. Relevant to the situation, necessary book-laden fairy tale appreciation enrichment CLIL suitable for grade 3 students, both fromthe aspect of content, presentation, language and readability, and graphics. The method used in this study is the research and development (research and development of the Borg and Gall.

  6. Petunia Germinating Pollen S/D3 Interacts with S-RNases in Petunia hybrida Vilm.

    Yan-Xia Guo; Yan-Sheng Zhang; Yong-Biao Xue


    Self-incompatibility (SI) is a genetic mechanism of self/non-self pollen recognition to prevent self-fertilization in many flowering plants and, in most cases, this is controlled by a multi-allelic S-locus. S-RNase and S-locus F box (SLF) proteins have been shown to be the female and male determinants of gametophytic selfincompatibility (GSI), respectively, in the Solanaceae, Scrophulariaceae and Rosaceae. Nevertheless, it is thought that additional factors are required for the SI response. Herein, we constructed a mature anther cDNA library from a self-incompatible Petunia hybrida Vilm. line of the S3S3 haplotype. Using AhS2-RNase from Antirrhinun hispanicum as a bait for yeast two-hybrid screening, we found that petunia germinating pollen (PGP) S/D3 was capable of interacting physically with the bait. However, the interaction lacked haplotype specificity. The PGPS/D3 gene is a single copy gene that is expressed in tissues such as the style, ovary,pollen, and leaf. The PGPS/D3::GFP (green fluorescence protein) construct was detected in both the membrane and cytoplasm. The implications of these findings in the operation of S-RNase-based SI are discussed.


    Supriyatno Supriyatno


    Full Text Available The onjectives of this research are to describe (1 the preparation of school self-evaluation in improving school accreditation; (2 The visitation in improving school accreditation; (3 The results of school accreditation. The type of the research is qualitative and uses ethnography design. The site of the study is SD Negeri 2 Mranti Purworejo District, Purworejo. Techniques for collecting data used are interviews, observations, and documentation. The results of this research are as follows: (1 Preparation of school self-evaluation is conducted by a special team formed by the principal. The preparation done before the new school year, it takes place by collecting data from the SNP. EDS is consisting of EDS instrument and the physical evidence for each item SNP. The preparation is conducted byhaving a checklist for each item in the SNPs form that describes the real condition of the school; (2 the visitation process in improving schools accreditation runs smoothly and according to the procedure. The process begins with the submission of the letter that comes with the implementation of the accreditation document to School Accreditation Association (BAS of district; (3 the accreditation result increases from 79 in 2005 to 86.81 in 2010.

  8. Inelastic magnetic electron scattering form factors of the 26Mg nucleus

    Khalid S Jassim; Raad A Radhi; Najlla M Hussain


    Magnetic electron scattering (3) form factors with core polarization effects, energy levels and (3) values to 3+ states of the 26Mg nucleus have been studied using shell model calculations. The universal sd of the Wildenthal interaction, universal sd-shell interaction A, universal sd-shell interaction B, are used for the sd-shell orbits. Core polarization effects according to microscopic theory are taken into account by the excitations of nucleons from the (11/2 13/2 11/2) core and also from valence 15/2 21/2 13/2 orbits into higher shells, with $4\\hbar \\omega$ excitation. In form factor calculations, the universal sd-shell interaction B for the sd-shell is used with the Michigan three-range Yakawa effective NN interaction as a residual interaction for the core polarization calculations. The wave functions of the radial single-particle matrix elements have been calculated using harmonic oscillator potentials. The level schemes are compared with the experimental data up to 9.902 MeV. In this study, very good agreements are obtained for all nuclei. Results from 3 form factor calculations with the inclusion of core polarization and new -factors give good agreement with the experimental data.

  9. Enhancement of Alcohol Metabolism by Sprouted Peanut Extract in SD Rats

    Seo, Ji Yeon; Kim, Seong Soon; Kim, Jong-Sang


    Excessive ethanol intake is known to induce a number of physiological symptoms, including headache, dizziness and vertigo. In this study, we investigated the attenuation effect of sprouted peanut extract (SPE) on ethanol-induced hangover in male Sprague-Dawley rats. The animals were divided into five groups: the control group, which was administered ethanol only; the ethanol plus SPE experimental groups, which were administered ethanol and 100, 200, or 400 mg SPE/kg b.w.; and the positive con...

  10. P2X7 Receptor Mediated Growth-Inhibitory Effect in KG1 a Cell Line

    Xiujun Zhang; Lijun Meng


    This study was conducted to investigate ATP-induced growth inhibition in human leukemic cells KGla.METHoDS ATP inhibited cell growth was analyzed by MTSassay.Extemalization of phosphatidylserine could be detected byAnnexin-V-FITC apoptosis staining after activation of the P2X7 re-ceptor.P2X7 mediated pore formation was detected in KGla cellsby Yo-Pro-1 uptake assay.RESUlTS ATP inhibited cell growth in a dose-dependent man-ner.The cytotoxic effect could be blocked by P2X7 antagonists,oxidized ATP(OATP)and KN62.Externalization of phosphatidyl-serine could be detected in a time-dependent manner.P2X7 medi-ated pore forigation could be detected in KGla cells.These effectscould not be observed in P2X7 null Ramos cells.CONCLUSIoN The results and our previously reports thatmRNA,protein expression and calcium response of the P2X7receptor in KGla cells,suggested that extracellular ATP effectivelyinduces growth inhibition through apoptosis in KGla cells byactivation of P2X7 receptor,and that may be mediated by extracel-lular Ca2+ineux and pore formation.

  11. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model

    Kim, Hyo-Seon; Kim, Hyeong-Geug; Lee, Hye-Won; Lee, Sung-Bae; Lee, Jin-Seok; Im, Hwi-Jin; Kim, Won-Yong; Lee, Dong-Soo; Son, Chang-Gue


    We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A. iwayomogi, A. xanthioides, and S. miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis. Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly). Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily. DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII. CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents. Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII. Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII. The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection. Administration of CGXII normalized the protein and gene expression levels of these cytokines. Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects. PMID:27340416

  12. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model

    Hyo-Seon Kim


    Full Text Available We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A. iwayomogi, A. xanthioides, and S. miltiorrhiza, against dimethylnitrosamine- (DMN- induced hepatofibrosis. Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly. Rats were orally given distilled water, CGXII (50 or 100 mg/kg, or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg daily. DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII. CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents. Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII. Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII. The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection. Administration of CGXII normalized the protein and gene expression levels of these cytokines. Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects.

  13. The pathogenicitv of melamine on fetal kidney in SD rats%三聚氰胺对SD胎鼠肾脏致病性研究

    蔡仕彬; 吴玉; 冯洋; 刘智涛; 苏萍; 王继红; 杜永洪


    目的:研究三聚氰胺在SD大鼠胚胎发育过程中对胎鼠肾的致病性.方法:将加只SD孕鼠随机分为4个三聚氰胺组和1个对照组,用浓度分别为360、480、600、720mg/(kg·d)三聚氰胺悬液连续灌胃,对照组灌胃2ml蒸馏水.生产后采用ELISA法检测新生鼠血液和肾脏中三聚氰胺含量,常规HE染色观察新生鼠肾组织的病理变化.结果:各组新生鼠血液中均可检测到三聚氰胺;600、720 mg/(kg·d)组新生鼠肾三聚氰胺浓度显著高于对照组.病理组织学检查发现600 mg/(kg·d)组肾小球细胞数量增多,体积增大,髓旁毛细血管扩张充血.720mg/(kg·d)组肾小管和肾盂扩张,未见结石和明显黄色沉淀物.结论:三聚氰胺通过胎盘屏障进入胎鼠体内,沉积在肾脏,对胎鼠肾生长发育具有损伤作用,损伤主要集中在肾小管和肾间质.%Objective:To study the pathogenicity of Melamine in the embryonic kidney development of SD rat. Methods:40 pregnant SD rats were randomized into 4 Melamine groups and the normal control group with 8 rats per group. The rats of the 4 Melamine groups were fed the Melamine with the dosage range of 360,480,600, and 720 mg/( kg·d ), respectively. The rats of the normal control group were given 2 ml of distilled water by oral gavage per day. The concentration of Melamine was detected by enzyme-linked immunosorbent assay (ELISA) in the blood and kidneys of the newborn rats. HE staining was used to examine the histopathological change of newborn rat kidneys. Results:Melamine was found in the blood of newborn rats per group. The concentration of melamine in 600, 720 mg/( kg· d ) dose groups were significantly higher than that of the normal control group(P<0.05 ). Pathological examination showed that hyperplasia of glomerulus in the 600 mg/( kg· d ) dose group, and size enlarged, The blood capillary in the renal medulla expanded with RBCs. Kidney tubular and pelvis expanded significantly. The urinary calculus

  14. Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma

    Puran Fadakar


    Full Text Available Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including a miR-17/92 cluster in retinoblastoma cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT and bromo-2′-deoxyuridine (BrdU assays. Then, the expression patterns of four miRNAs (18a, 20a, 22, and 34a were investigated in the treated SD-208 (0.0, 1, 2 and 3 µM and untreated Y-79 cells. A remarkable inhibition of the cell proliferation was found in Y-79 cells treated with SD-208 versus untreated cells. Also, the expression changes were observed in miRNAs 18a, 20a, 22 and 34a in response to SD-208 treatment (P<0.05. The findings of the present study suggest that the anti-cancer effect of SD-208 may be exerted due to the regulation of specific miRNAs, at least in this particular retinoblastoma cell line. To the best of the researchers’ knowledge, this is the first report demonstrating that the SD-208 could alter the expression of tumor suppressive miRNAs as well as oncomiRs in vitro. In conclusion, the present data suggest that SD-208 could be an alternative agent in retinoblastoma treatment.

  15. High-precision Mg isotopic systematics of bulk chondrites

    Schiller, Martin; Handler, Monica R.; Baker, Joel A.


    chondrite parent bodies had precisely the same initial levels of 26Al, although planetesimals and planets appear to have accreted from material with a mean initial ( 26Al/ 27Al) 0 in the range of 2.1 to 6.7 × 10 - 5 . The average stable Mg isotope composition of all analysed chondrites, with the exception of a chondrule from the CBa chondrite Gujba ( δ25Mg DSM-3 = -0.032 ± 0.035‰), is δ25Mg DSM-3 = -0.152 ± 0.079‰ (2 sd) and is indistinguishable from that of the Earth's mantle.

  16. Tenoxicam 20 mg or 40 mg after thoracotomy: a prospective, randomized, double-blind, placebo-controlled study.

    Merry, A F; Sidebotham, D A; Middleton, N G; Calder, M V; Webster, C S


    Forty-five adults undergoing thoracotomy were randomized to receive placebo, tenoxicam 20 mg or tenoxicam 40 mg IV during chest wall closure. All patients received intraoperative fentanyl and intercostal blocks followed by morphine by patient-controlled analgesia. Patient numbers 13 to 45 also received thoracic epidural analgesia by continuous infusion of bupivacaine 0.125%, patient numbers 25 to 45 having fentanyl 2 microg/ml added to the epidural infusion. Efficacy parameters and adverse reactions were assessed over the first 24 hours postoperatively. On a 100 mm visual analogue scale, mean (SD) pain at rest (adjusted area under curve for hours 1 to 24) was 25.8 (12.5), 17.4 (14.8) and 16.5 (13.3) mm for groups receiving placebo, 20 mg and 40 mg tenoxicam, respectively (ANOVA: P<0.05). There were no significant differences between study groups postoperatively in pain on coughing, opioid consumption, blood gas measurements, nausea, vomiting, sedation, blood loss, haemoglobin or serum creatinine. One patient in each tenoxicam group reported epigastric pain, rated moderate. These data support the inclusion of tenoxicam 20 mg IV in the management of pain at rest for patients undergoing thoracotomy, but do not show additional benefit for a higher dose.

  17. Hubungan Konsumsi Junk Food dengan Status Gizi Lebih pada Siswa SD Pertiwi 2 Padang

    Rizki Nur Amalia


    Full Text Available AbstrakGizi lebih adalah keadaan tubuh seseorang yang mengalami berat badan berlebih karena kelebihan jumlah asupan energi yang disimpan dalam bentuk cadangan berupa lemak. Prevalensi gizi lebih pada anak di Indonesia mencapai 10,4. Salah satu faktor risiko terjadinya gizi lebih adalah kebiasaan mengonsumsi junk food. Tujuan penelitian ini adalah menentukan hubungan antara konsumsi junk food dengan status gizi lebih pada anak usia sekolah. Penelitian ini adalah penelitian analitik dengan rancangan cross sectional terhadap populasi penelitian yaitu siswa kelas 1 – 5 di SD Pertiwi 2 Padang sebanyak 250 siswa. Teknik pengambilan data dilakukan dengan menggunakan kuesioner semi kuantitatif FFQ.  Status gizi ditentukan dengan pengukuran berat badan dan tinggi badan yang hasilnya dikategorikan menggunakan standar antropometri penilaian status gizi anak menurut Depkes Indonesia. Pada hasil penelitian didapatkan bahwa siswa yang memiliki status gizi lebih hanya 23,6% dengan rata – rata IMT 16,9±3,69. Rata – rata frekuensi konsumsi junk food 4,6±2,9 kali per hari dan rata – rata asupan energi junk food 1046,5±918,4 kkal per hari. Kesimpulan penelitian ini adalah terdapat hubungan yang bermakna antara konsumsi frekuensi konsumsi junk food dengan kejadian gizi lebih (p = 0,013 dan tidak terdapat hubungan yang bermakna antara asupan energi junk food dengan kejadian gizi lebih (p = 0,120.Kata kunci: gizi lebih, junk food, FFQ AbstractOverweight is a condition of an individual who suffer from excessive weight due to an excess of energy intake stored in fat tissue. Prevalence of overweight in children in Indonesia reaches 10,4 %. One of the risk factors contributing to this condition is consuming junk food. The objective of this study was to identify the relationship of junk food consumption and overweight in students. This research is an analytic study conducted in a cross sectional design using 250  students of class 1-5 in SD Pertiwi 2 Padang

  18. Comparative metabolism and pharmacokinetics of diisobutyl ketone and diisobutyl carbinol in male SD rats.

    Zhang, Fagen; Bartels, Michael J; Clark, Amy J; Staley, Jen L; Lardie, Tom S; Markham, Dan A; Hughes, Brian J; Ball, Nicholas S


    Diisobutyl ketone (DIBK) and diisobutyl carbinol (DIBC) are important organic solvents widely used as industrial intermediates. It was hypothesized that DIBC and DIBK have common metabolic pathways and metabolites, and as such, toxicological data on DIBK could be used to characterize the hazards of DIBC. To confirm or refute this hypothesis a comparative metabolism and pharmacokinetics assessment of DIBK and DIBC was conducted. Dosing was via single oral gavage dosing in male SD rats, followed by blood collection, metabolite identification, major biomarker quantitation, and pharmacokinetics analysis. Overall, the major metabolites of both DIBC and DIBK in blood were their corresponding monohydroxylated metabolites (DIBC alcohol and DIBK alcohol) with the site of hydroxylation at the σ and σ-1 positions, respectively. Quantitative analysis of DIBC, DIBK, DIBC-alcohol, and DIBK-alcohol in blood samples collected from 5min to 120h after single dosing indicated the following: (1) DIBC and DIBK are both well absorbed following oral gavage with substantial evidence of enterohepatic recirculation of DIBK, DIBC, DIBK-alcohol, and DIBC-alcohol; (2) DIBK and DIBC are interconverted metabolically in rats; (3) DIBC and DIBK have similar bioavailability after oral administration; (4) higher systemic exposure was found for DIBK-alcohol than DIBC-alcohol, implying that DIBC-alcohol may be more easily conjugated and eliminated in bile. In summary, the metabolic similarities and the difference in systemic exposure to metabolites between these substances observed in the current study support the hypothesis that DIBC might have a lower potential toxicity than that of DIBK. The current study results support that toxicological data on DIBK could be used to characterize the hazards of DIBC. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  19. The effect of childbirth on carcinogenesis of DMBA-induced breast cancer in female SD rats

    Ji-An Zhao; Jin-Jun Chen; Ying-Chao Ju; Jian-Hua Wu; Cui-Zhi Geng; Hui-Chai Yang


    Many epidemiologic and clinical studies have indicated that the frequency of breast cancer was lower in parous women than in nulliparous women.Moreover,the incidence of breast cancer has been reported to be lower in women with early childbirth than in women with late childbirth.To verify the effect of childbirth and the age at first childbirth on carcinogenesis and progression of breast cancer,we induced breast cancer by 7,12-dimethylbenanthracene (DMBA) in 120 female Sprague-Dawley (SD) rats,and divided them into control or experimental (DMBA-treated) nulliparous,early childbirth,and late childbirth groups to observe the incidence,latency,and size of breast cancer.Argyrophilic nucleolar organizer regions (AgNOR) count and the expression of C-erbB-2,proliferating cell nuclear antigen (PCNA),Ki-67,and minichromosome maintenance protein 2 (MCM2) in breast cancer tissues were detected by immunohistochemistry.The breast cancer incidences were 95.0%,16.7%,and 58.8% in the experimental nulliparous,early childbirth,and late childbirth groups,respectively (all P < 0.05).Between any two of these groups,the latency was significantly different,but tumor size was similar.AgNOR count and the expression of C-erbB-2,PCNA,Ki-67,and MCM2 were significantly higher in the experimental nulliparous group than in the experimental early or late childbirth groups (P < 0.05),but no significant differences were observed between the latter two groups.Taken together,the results suggest that childbirth,especially early childbirth,can reduce the incidence and postpone the onset of DMBA-induced breast cancer.

  20. Purification and Characterization of the Manganese(II) Oxidizing Protein from Erythrobacter sp. SD-21

    Nakama, K. R.; Lien, A.; Johnson, H. A.


    The manganese(II) oxidizing protein (Mop) found in the alpha-proteobacterium Erythrobacter sp. SD-21 catalyzes the formation of insoluble Mn(III/IV) oxides from soluble Mn(II). These Mn(III/IV) oxides formed are one of the strongest naturally occurring oxides, next to oxygen, and can be used to adsorb and oxidize toxic chemicals from the surrounding environment. Because of the beneficial use in the treatment of contaminated sources, the mechanism and biochemical properties of this novel enzyme are being studied. Due to low expression levels in the native host strain, purification of Mop has been problematic. To overcome this problem the gene encoding Mop, mopA, was cloned from the native host into a C-terminal histidine tag vector and expressed in Escherichia coli cells. Affinity chromatography under denaturing conditions have been applied in attempts to purify an active Mop. Western blots have confirmed that the protein is being expressed and is at the expected size of 250 kDa. Preliminary characterization on crude extract containing Mop has shown a Km and vmax value of 2453 uM and 0.025 uM min-1, respectively. Heme and pyrroloquinoline quinone can stimulate Mn(II) oxidizing activity, but hydrogen peroxide does not affect activity, despite the sequence similarity to animal heme peroxidase proteins. Research has been shown that calcium is essential for Mop activity. Purifying an active Mn(II) oxidizing protein will allow for a better understanding behind the enigmatic process of Mn(II) oxidation.

  1. Leveraging master-slave OpenFlow controller arrangement to improve control plane resiliency in SD-EONs.

    Chen, Xiaoliang; Zhao, Bin; Ma, Shoujiang; Chen, Cen; Hu, Daoyun; Zhou, Wenshuang; Zhu, Zuqing


    In this paper, we study how to improve the control plane resiliency of software-defined elastic optical networks (SD-EONs) and design a master-slave OpenFlow (OF) controller arrangement. Specifically, we introduce two OF controllers (OF-Cs), i.e., the master and slave OF-Cs, and make them work in a collaborative way to protect the SD-EON against controller failures. We develop a controller communication protocol (CCP) to facilitate the cooperation of the two OF-Cs. With the CCP, the master OF-C (M-OF-C) can synchronize network status to the slave OF-C (S-OF-C) in real time, while S-OF-C can quickly detect the failure of M-OF-C and take over the network control and management (NC&M) tasks timely to avoid service disruption. We implement the proposed framework in an SD-EON control plane testbed built with high-performance servers, and perform NC&M experiments with different network failure scenarios to demonstrate its effectiveness. Experimental results indicate that the proposed system can restore services in both the data and control planes of SD-EON jointly while maintaining relatively good scalability. To the best of our knowledge, this is the first demonstration that realizes control plane resiliency in SD-EONs.

  2. Comparison of features on SD-OCT between acute central serous chorioretinopathy and exudative age-related macular degeneration.

    Ahn, Seong Joon; Kim, Tae Wan; Huh, Jang Won; Yu, Hyeong Gon; Chung, Hum


    To compare the spectral-domain optical coherence tomography (SD-OCT) features of acute central serous chorioretinopathy (CSC) versus exudative age-related macular degeneration (AMD) and explore disease-specific features of each disease. SD-OCT images obtained at the time of diagnosis in 39 eyes with acute CSC (symptom onset features. The relationship between anatomical findings and visual function was also assessed. There were significant morphologic differences on SD-OCT between the two diseases, including the presence and height of retinal fluid and morphologic changes of retinal pigment epithelium (RPE). Multiple regression analysis revealed that a reflective band with posterior shadowing was a disease-specific finding indicating exudative AMD; however, other SD-OCT findings were attributed to differences in age of onset between the two diseases. Visual acuity was correlated with subretinal fluid in CSC, whereas pigment epithelial detachment, intraretinal fluid, and diverse RPE morphologic abnormalities were associated with visual decline in exudative AMD. A reflective band with posterior shadowing is a disease-specific feature of exudative AMD that may be useful for the differential diagnosis. High-resolution SD-OCT images of the retinal layers identified distinguishing pathologic features of the outer retina between the two diseases. The OCT features associated with visual function were different between the two diseases. Copyright 2012, SLACK Incorporated.

  3. Threshold of Multiple Stick-Slip Chaos for an Archetypal Self-Excited SD Oscillator Driven by Moving Belt Friction

    Li, Z. X.; Cao, Q. J.; Léger, A.

    In this paper, we investigate the multiple stick-slip chaotic motion of an archetypal self-excited smooth and discontinuous (SD) oscillator driven by moving belt friction, which is constructed with the SD oscillator and the classical moving belt. The friction force between the mass and the belt is modeled as a Coulomb friction for this system. The energy introduction or dissipation during the slip and stick modes in the system is analyzed. The analytical expressions of homoclinic orbits of the unperturbed SD oscillator are derived by using a special coordinate transformation without any pronominal truncation to retain the natural characteristics, which allows us to utilize the Melnikov’s method to obtain the chaotic thresholds of the self-excited SD oscillator in the presence of the damping and external excitation. Numerical simulations are carried out to demonstrate the multiple stick-slip dynamics of the system, which show the efficiency of the prediction for stick-slip chaos of the perturbed self-excited system. The results presented herein this paper demonstrate the complicated dynamics of stick-slip periodic solutions, multiple stick-slip chaotic solutions and also coexistence of multiple solutions for the perturbed self-excited SD oscillator.

  4. Mg spin affects adenosinetriphosphate activity

    Tulub, Alexander A


    The Schlegel-Frisch ab initio molecular dynamics (ADMP) (DFT:B3LYP), T = 310 K, is used to study complexation between adenosinetriphosphate (ATP), ATP subsystem, and magnesium cofactor [Mg(H2O)6]2+, Mg subsystem, in a water pool, modeled with 78 water molecules, in singlet (S) and triplet (T) states. The computations prove that the way of ATP cleavage is governed by the electron spin of Mg. In the S state Mg prefers chelation of \\gamma-\\beta-phosphate oxygens (O1-O2), whereas in the T state it chelates \\beta-\\alpha-phosphate oxygens (O2-O3) or produces a single-bonded intermediate. Unlike the chelates, which initiate ionic reaction paths, the single-bonded intermediate starts off a free-radical path of ATP cleavage, yielding a highly reactive adenosinemonophosphate ion-radical, .AMP-, earlier observed in the CIDNP (Chemically Induced Dynamic Nuclear Polarization) experiment (A.A. Tulub, 2006). The free-radical path is highly sensitive to Mg nuclear spin, which through a hyperfine interaction favors the produc...

  5. Preliminary screening of Ni(II) metal tolerance and dye-decolorizing byNocardiopsis sp. SD8

    Ramasamy Thangaraj; Saha Subhasish; Dharumadurai Dhanasekaran; Nooruddin Thajuddin


    Objective:To reveal the screening of metal tolerance and dye-decolorizing ofNocardiopsis sp. Methods: NiSO4 and Congo red dye were used for evaluating the metal tolerance and dye-decolorizing of the randomly selected actinobacterial isolates. Results:Nocardiopsis sp.SD8 showed a better efficiency in Ni(II) tolerance, though a longer lag phase was observed for this microorganism grown for 7 days in integrated mismatch negativity. Interestingly, we also found thatNocardiopsis sp.SD8 had dye-decolorizing, hemolytic, lipase and protease activity. Conclusions:The present results revealed the bioremediation of metal resistant and diverse properties ofNocardiopsis sp.SD8 and further investigations are needed to extract and identify the potent molecule.

  6. Preliminary screening of Ni(II metal tolerance and dye-decolorizing by Nocardiopsis sp. SD8

    Ramasamy Thangaraj


    Full Text Available Objective: To reveal the screening of metal tolerance and dye-decolorizing of Nocardiopsis sp. Methods: NiSO4 and Congo red dye were used for evaluating the metal tolerance and dyedecolorizing of the randomly selected actinobacterial isolates. Results: Nocardiopsis sp. SD8 showed a better efficiency in Ni(II tolerance, though a longer lag phase was observed for this microorganism grown for 7 days in integrated mismatch negativity. Interestingly, we also found that Nocardiopsis sp. SD8 had dye-decolorizing, hemolytic, lipase and protease activity. Conclusions: The present results revealed the bioremediation of metal resistant and diverse properties of Nocardiopsis sp. SD8 and further investigations are needed to extract and identify the potent molecule.

  7. Hot subdwarfs from the ESO Supernova Ia Progenitor Survey - I. Atmospheric parameters and cool companions of sdB stars

    Lisker, T; Napiwotzki, R; Christlieb, N; Han, Z; Homeier, D; Reimers, D


    We present the analysis of a high-resolution, high-quality sample of optical spectra for 76 subdwarf B (sdB) stars from the ESO Supernova Ia Progenitor Survey (SPY). Effective temperature, surface gravity, and photospheric helium abundance are determined simultaneously by fitting the profiles of hydrogen and helium lines using synthetic spectra calculated from LTE and NLTE model atmospheres. We perform a detailed comparison of our measurements with theoretical calculations, both for single star evolution and for binary population synthesis models of close binary evolution. The luminosity evolution given by the standard EHB evolutionary tracks from Dorman et al. (1993) shows an overall agreement in shape with our observations, although a constant offset in luminosity exists. The various simulation sets for binary formation channels of sdB stars calculated by Han et al. (2003) are compared individually to our data for testing our current understanding of sdB formation processes and the physical effects involved...

  8. Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa.

    McCaughey, Laura C; Josts, Inokentijs; Grinter, Rhys; White, Paul; Byron, Olwyn; Tucker, Nicholas P; Matthews, Jacqueline M; Kleanthous, Colin; Whitchurch, Cynthia B; Walker, Daniel


    Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative approaches to antibiotic development are urgently required. Pyocins, produced by P. aeruginosa for intraspecies competition, are highly potent protein antibiotics known to actively translocate across the outer membrane of P. aeruginosa. Understanding and exploiting the mechanisms by which pyocins target, penetrate and kill P. aeruginosa is a promising approach to antibiotic development. In this work we show the therapeutic potential of a newly identified tRNase pyocin, pyocin SD2, by demonstrating its activity in vivo in a murine model of P. aeruginosa lung infection. In addition, we propose a mechanism of cell targeting and translocation for pyocin SD2 across the P. aeruginosa outer membrane. Pyocin SD2 is concentrated at the cell surface, via binding to the common polysaccharide antigen (CPA) of P. aeruginosa lipopolysaccharide (LPS), from where it can efficiently locate its outer membrane receptor FpvAI. This strategy of utilizing both the CPA and a protein receptor for cell targeting is common among pyocins as we show that pyocins S2, S5 and SD3 also bind to the CPA. Additional data indicate a key role for an unstructured N-terminal region of pyocin SD2 in the subsequent translocation of the pyocin into the cell. These results greatly improve our understanding of how pyocins target and translocate across the outer membrane of P. aeruginosa. This knowledge could be useful for the development of novel anti-pseudomonal therapeutics and will also support the development of pyocin SD2 as a therapeutic in its own right. © 2016 The Author(s).

  9. The use of SD-OCT in the differential diagnosis of dots, spots and other white retinal lesions

    Zaharova E


    Full Text Available Elena Zaharova1, Jerome Sherman1-31State University of New York's State College of Optometry, University Eye Center, New York, NY, USA; 2SUNY Eye Institute, New York, NY, USA; 3New York Eye Institute and Laser Center, New York, NY, USAPurpose: To demonstrate the utility of a retinal imaging technique using spectral domain optical coherence tomography (SD-OCT for creating a B-scan layer-by-layer analysis to aid in the differential diagnosis of various retinal dots, spots, and other white lesions.Design: Review.Methods: A retrospective review of imaging studies performed with SD-OCT (Topcon, 3DOCT-2000, Oakland, NJ at SUNY State College of Optometry.Results: B-scan layer-by-layer analysis and unique SD-OCT reflectivity patterns of the following retinal white lesions are reviewed in the order of their retinal layer localization: myelinated nerve fiber layer, cotton wool spot, exudates, edema residues, drusen, fundus albipunctatus, Stargardt disease, Bietti crystalline dystrophy, punctate inner choroidopathy (PIC, presumed ocular histoplasmosis syndrome (POHS, post-photocoagulation chorioretinal scarring, and osseous choristoma.Conclusion: The reviewed images demonstrate the utility of SD-OCT in the identification of the unique characteristics of the presented retinal pathologies. SD-OCT is ideal for retinal layer localization of lesions, thus enhancing the differential diagnosis of retinal dots, spots, and other white lesions. Even though true pathognomonic patterns are rare, highly suggestive findings of certain retinal abnormalities often facilitate immediate recognition and diagnosis.Keywords: SD-OCT, photoreceptor integrity line, retinal pigment epithelium, white dot syndrome, retinal pathology, imaging

  10. Uranium, Thorium, Potassium Contents of Materials in the Homestake Underground, Lead, SD

    Roggenthen, W.; Smith, A.


    The uranium, thorium, and potassium contents (UTK) of materials in the underground laboratory at the Homestake DUSEL in Lead, SD, can significantly affect the radioactive backgrounds experienced by detectors in physics experiments planned for the facility. Many highly sensitive experiments require low activities both in terms of direct gamma and neutron radiation as well as radon that might emanate from the materials. Specific issues requiring characterization include evaluation of the rock in which laboratory rooms will be emplaced, the design of the cement and aggregate used in shotcreting the laboratory areas used for the physics experiments, estimates of requirements for shielding from radiation from the country rock, and estimates of radon emanation. The rocks of most importance from this standpoint in the laboratory underground include the Poorman Formation, the Yates Member of the Poorman Formation, and Tertiary igneous rocks. The laboratory at the 7400 level currently is planned for construction in the Yates, whereas the laboratories at the 4850 level are scheduled for construction in both the general Poorman Fm. and the Yates. The UTK contents of Poorman and Yates from the underground are generally very low (0.1 - 0.2 ppm U and 0.2 - 0.4 ppm Th). Rhyolitic intrusive rocks, which occur as thin dikes in the vicinity of the 4850 level laboratory, have substantially higher values that are reflective of their more silicic nature with typical U values in the range of 8 - 9 ppm. Many of the laboratory rooms for the detector experiments will have walls that have been shotcreted and floors finished with concrete. The concrete consists of at least two components, the cement and the aggregate. The choices for cement material are limited by local availability but the UTK content is in the 3 ppm range for U. Analyses of potential aggregates show that sources of aggregate from standard regional aggregate resources appear to have higher values of UTK content than is


    Yuliyati -


    menunjukkan bahwa model budaya baca-tulis efektif untuk mengembangkan kemampuan membaca dan menulis serta aktivitas baca-tulis siswa SD untuk mengonstruk budaya baca-tulis, namun semua unsur sekolah harus berupaya keras mengonstruksi dan menerapkan model. Kata kunci: baca-tulis, balance literacy, literasi, sekolah dasar

  12. Hubungan Sanitasi Lingkungan Rumah dengan Kejadian Askariasis dan Trikuriasis pada Siswa SD N 29 Purus Padang

    Hildya Kusmi


    Full Text Available Abstrak Prevalensi infeksi kecacingan masih tinggi terutama pada anak usia sekolah dasar. Cacing yang sering menginfeksi yaitu Ascaris lumbricoides dan Trichuris trichiura. Infeksi ini erat kaitannya dengan masalah lingkungan, perilaku manusia dan manipulasi terhadap lingkungan. Tujuan penelitian adalah menentukan hubungan sanitasi lingkungan rumah yaitu kepemilikan jamban keluarga yang sehat, ketersediaan sumber air bersih, sarana pembuangan sampah dan jenis lantai rumah dengan kejadian askariasis dan trikuriasis. Ini adalah penelitian analitikdengan desain cross-sectional study. Jumlah populasi sebanyak 71 orang dengan jumlah subjek sebanyak 55 orang.Pengumpulan data dilakukan dengan pemeriksaan tinja dan kuesioner. Metode analisis data menggunakan uji chisquare.Hasil penelitian menunjukkan bahwa persentase infeksi kecacinganpada siswa SD Negeri 29 Purus Padang adalah 38%, terdiri dari; infeksi Ascaris lumbricoides (33%, Trichuris trichiura (9,1% dan infeksi kedua spesies (3,6%. Hasil uji chi-square menunjukkan tidak ada hubungan yang bermakna antara kepemilikan jamban keluarga, ketersediaan sumber air bersih, kepemilikan sarana pembuangan sampah dan jenis lantai rumah dengan angka kejadian askariasis dan trikuriasis (p > 0,05. Masih tingginya infeksi kecacingan pada siswa sekolah dasar perluperhatian yang lebih baik misalnya diadakannya program pemberantasan kecacingan baik oleh sekolah maupun petugas kesehatan setempat.Kata kunci: infeksi kecacingan, sanitasi lingkungan, askariasis, trikuriasis Abstract Prevalence of worms infestation is still high, especially found among children at the elementary school age. Type of worms that often infect are Ascaris lumbricoides and Trichuris trichiura. The infection is  related to envi ronment issues, human behavior and manipulation of the environment.  The objective of this study was to determine the relationship between environmental sanitation of home, consist of latrine ownership, availability of

  13. Low Energy Positive-Negative Pion Interactions with S-D Shell Nuclei.

    Tacik, Roman

    A magnetic spectrometer has been commissioned for use in performing low energy pion scattering experiments. It has been used to measure the differential cross sections for the elastic scattering of 50 MeV (pi)('(+OR-)) from ('12)C, ('18)O, and ('26)Mg targets, as well as the inelastic scattering to the 2(,1)('+) states of these nuclei. The analysis of the elastic scattering data has been performed with an optical potential model. It is found that the (pi)('(+OR-)) elastic cross sections for ('12)C and ('18)O are well described by calculations employ - ing a global parameter set('1), which has been previously shown to reproduce (pi)('(+OR-)) elastic scattering data for a range of nuclei. The (pi)('(+OR-)) elastic data for ('26)Mg require a variation of the p-wave potential parameters. A similar requirement is seen with (pi)('(+OR -)) - ('32)S elastic data('2). Distorted wave calculations, inputting separate neutron and pro- ton transition densities, have been performed for the analysis of the inelastic data. These calculations demonstrate a strong sensitivity of (pi)('(+OR-)) to protons, and (pi)('-) to neutrons, present in the nucleus. By varying the strengths of the neutron and proton transition densities, in order to reproduce the (pi)('(+OR -)) inelastic cross sections, it is possible to determine the ratio of neutron to proton matrix elements (M(,n)/M(,p)) for the given 2('+) states. It is shown that the value of M(,n)/M(,p) obtained in this way is independent of the optical potential param- eters used in the calculation. The extracted values of M(,n)/M(,p) are: 0.97 (+OR-) 0.08, 1.81 (+OR-) 0.15, and 0.90 (+OR-) 0.07 for ('12)C, ('18)O, and ('26)Mg. respectively. These values are in agreement with those obtained by other means. ('1)J. A. Carr et. al., Phys Rev C25 (82) 952. ('2)R. J. Sobie, PhD Thesis, University of Toronto, 1984.

  14. B{sup *}{sub s,d} → μ{sup +}μ{sup -} and its impact on B{sub s,d} → μ{sup +}μ{sup -}

    Xu, Guang-Zhi [Liaoning University, Department of Physics, Shenyang (China); Beihang University, Beijing Key Laboratory of Advanced Nuclear Energy Materials and Physics, and School of Physics, Beijing (China); Qiu, Yue [Beihang University, Beijing Key Laboratory of Advanced Nuclear Energy Materials and Physics, and School of Physics, Beijing (China); Shen, Cheng-Ping; Zhang, Yu-Jie [Beihang University, Beijing Key Laboratory of Advanced Nuclear Energy Materials and Physics, and School of Physics, Beijing (China); CAS Center for Excellence in Particle Physics, Beijing (China)


    This study investigates B{sup *}{sub s,d} → μ{sup +}μ{sup -} in the dimuon distributions and the hadronic contribution B{sub s,d} → B{sup *}{sub s,d}γ → μ{sup +}μ{sup -}. The μ{sup +}μ{sup -} decay widths of the vector mesons B{sup *}{sub s,d} are approximately a factor of 700 larger than the corresponding scalar mesons B{sub s,d}. The ratio of the branching fractions obtained, (Br(B{sup *}{sub s,d}→μ{sup +}μ{sup -}))/(Br(B{sub s,d}→μ{sup +}μ{sup -})), is approximately (0.3 x eV)/(Γ(B{sup *}{sub s,d}→B{sub s,d}γ)). The hadronic contribution B{sub s,d} → B{sup *}{sub s,d}γ → μ{sup +}μ{sup -} is also estimated. The relative increase in the B{sub s,d} → μ{sup +}μ{sup -} amplitude is approximately (0.01 ± 0.006)√((Γ(B{sup *}{sub s,d}→B{sub s,d}γ))/(100 eV)). If we select Γ(B{sup *}{sub s,d} → B{sub s,d}γ) = 2 eV, then the branching fractions of the vector mesons to the lepton pair are 5.3 x 10{sup -10} and 1.6 x 10{sup -11} B{sup *}{sub s} and B{sup *}{sub d}, respectively. If we select Γ(B{sup *}{sub s,d} → B{sub s,d}γ) = 200 eV, then the updated branching fractions of the scalar mesons to the muon pair are (3.78 ± 0.25) x 10{sup -9} and (1.09 ± 0.09) x 10{sup -10} for B{sub s} and B{sub d}, respectively. If we select the recent predicted M1 widths Γ(B{sup *}{sub s,d} → B{sub s,d}γ) = 313, 1230 eV (arXiv:1607.02169), then the updated branching fractions are (3.8 ± 0.3) x 10{sup -9} and (1.2 ± 0.1) x 10{sup -10} for B{sub s} → μ{sup +}μ{sup -} and B{sub d} → μ{sup +}μ{sup -}, respectively. Further studies on B{sup *}{sub s,d}, including those on dielectron decay and two-body decay with J/ψ, should be conducted. (orig.)

  15. Studies on the toxic effects of periodontal sustained release drug containing ornidazole and pefloxacin mesylate on early embryonic development of SD rat

    Zheng-mou DONG


    Full Text Available Objective To evaluate the toxic effects of periodontal sustained release drug containing ornidazole and pefloxacin mesylate on early embryonic development of SD rats.Methods A total of 100female SD rats were randomly divided into negative control,low-,medium-,high-dose group and intervention group(20each.Rats in low-,medium-and high-dose group were fed daily with the sustained release drug at 1,4,and 8g/kg respectively;those in negative control group were fed daily with distilled water from the 14th day before mating to the 7th day of pregnancy continuously,and those in intervention group received cyclophosphamide(40mg/kgby intraperitoneal injection for 5successive days.During this period,the general status,mating,pregnancy,coefficient of ovary and uterus,the numbers of corpus luteum,nidation,live births,stillbirths,absorbed embryo,prenidatory and postnidatory mortality,serum testosterone(Tand estradiol(E2were determined respectively.Histopathologic examination of the ovary and uterus,immunohistochemical observation of ovaries for proliferating cell nuclear antigen(PCNAand Bcl-2associated X protein(Baxwere also performed respectively.Results The general status of those rats was good except one in the low-dose group and one in the intervention group died on the 14th day of administration,and one in negative control and one in high dose group died on the 5th day of pregnancy,respectively.The body weight of animals decreased significantly(P 0.05.The serum T level in medium-and high-dose group and the E2level in high-dose group declined compared to that in negative control group(P < 0.05.Conclusions Although the periodontal sustained release drug containing ornidazole and pefloxacin mesylate shows no toxicity to the early embryonic development of SD rats,the high dose drug has certain toxicity to ovary.Declined serum concentrations of T and E2,reduced expression of PCNA,and increased Bax may be the causes of the toxicity.

  16. CsMgPO4

    Nikolay S. Slobodyanik


    Full Text Available Caesium magnesium orthophosphate is built up from MgO4 and PO4 tetrahedra (both with . m. symmetry linked together by corners, forming a three-dimensional framework. The Cs atoms have .m. site symmetry and are located in hexagonal channels running along the a- and b-axis directions.

  17. 40 CFR Table 28 to Subpart G of... - Deck Seam Length Factors a (SD) for Internal Floating Roof Tanks


    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Deck Seam Length Factors a (SD) for Internal Floating Roof Tanks 28 Table 28 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL... specific information is available, these factors can be assumed to represent the most common bolted...

  18. Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116.

    Gao, Mang; Song, Xiaojin; Feng, Yingang; Li, Wenli; Cui, Qiu


    A heterotrophic microalga, strain SD116, with the ability to produce high concentrations of docosahexaenoic acid (DHA, C22:6n-3) was isolated from Shuidong Bay, Guangdong Province, China. Nucleotide sequence analysis of the 18S rDNA of SD116 showed that the strain has a close phylogenetic relationship to Aurantiochytrium species. The highest rates for growth and DHA accumulation for SD116 were obtained in 6.0% glucose, 2.0% yeast extract, and 50% artificial seawater (ASW) at a pH of 7 at 28°C. The maximum total lipid content reached 56.3% of the dry cell weight (DCW), and the maximum DHA content accounted for 50.9% of the total fatty acid (TFA) content. It was further found that urea may be a potential nitrogen source for industrial fermentation because of its cheap price and ability to induce a relatively high biomass and lipid production capacity. Using 5 L fermenters, the DCW, total lipid content, and DHA yield were found to be 70.43 g L(-1), 71.09% of the DCW, and 17.42 g L(-1) (34.79% of the TFA), respectively. The results show that Aurantiochytrium sp. SD116 is a promising candidate for commercial DHA production and could be useful for the synthesis of biomass-related products.

  19. Application of chirally-deuterated (S)-D-(6-2H1)glucose to conformational studies

    Deuterated sugars are widely used to elucidate mechanisms of biosynthesis and of chemical reactions, and to confirm assignments of complex NMR or mass spectra. To date, however, there are few reported syntheses for regio and stereospecifically deuterated pyranoses. Chirally-deuterated (S)-D-(6-**2...

  20. Preliminary screening and identification of stem cell-like sphere clones in a gallbladder cancer cell line GBC-SD*

    Bao-bing YIN; Shuang-jie WU; Hua-jie ZONG; Bao-jin MA; Duan CAI


    This paper aims to screen and identify sphere clone cells with characteristics similar to cancer stem cellsin human gallbladder cancer cell line GBC-SD. GBC-SD cells were cultured in a serum-free culture medium with different concentrations of the chemotherapeutic drug cisplatin for generating sphere clones. The mRNA expressions of stem cell-related genes CD133, OCT-4, Nanog, and drug resistance genes ABCG2 and MDR-1 in sphere clones were detected by quantitative real-time polymerase chain reaction (PCR). Stem cell markers were also analyzed by flow cytometry and immunofluorescent staining. Different amounts of sphere clones were injected into nude mice to test their abilities to form tumors. Sphere clones were formed in serum-free culture medium containing cisplatin (30 pmol/L).Flow cytometry results demonstrated that the sphere clones expressed high levels of stem cell markers CD133+ (97.6%) and CD44+ (77.9%) and low levels of CD24+ (2.3%). These clones also overexpressed the drug resistance genes ABCG2 and MDR-1. Quantitative real-time PCR showed that sphere clones expressed stem cell genes Nanog and OCT-4 284 and 266 times, respectively, more than those in the original GBC-SD cells. Immunofluorescent staining showed that sphere clones overexpressed OCT-4, Nanog, and SOX-2, and Iow expressed MUG1 and vimentin. Tumor formation experiments showed that 1 x 103 sphere clone cells could induce much larger tumors in nude mice than 1 x 105 GBC-SD cells. In conclusion, sphere clones of gallbladder cancer with stem cell-like characteristics can be obtained using suspension cultures of GBC-SD cells in serum-free culture medium containing cisplatin.

  1. The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2.

    Dall'Olio, Fabio; Malagolini, Nadia; Chiricolo, Mariella; Trinchera, Marco; Harduin-Lepers, Anne


    The histo-blood group antigens are carbohydrate structures present in tissues and body fluids, which contribute to the definition of the individual immunophenotype. One of these, the Sd(a) antigen, is expressed on the surface of erythrocytes and in secretions of the vast majority of the Caucasians and other ethnic groups. We describe the multiple and unsuspected aspects of the biology of the Sd(a) antigen and its biosynthetic enzyme β1,4-N-acetylgalactosaminyltransferase 2 (B4GALNT2) in various physiological and pathological settings. The immunodominant sugar of the Sd(a) antigen is a β1,4-linked N-acetylgalactosamine (GalNAc). Its cognate glycosyltransferase B4GALNT2 displays a restricted pattern of tissue expression, is regulated by unknown mechanisms - including promoter methylation, and encodes at least two different proteins, one of which with an unconventionally long cytoplasmic portion. In different settings, the Sd(a) antigen plays multiple and unsuspected roles. 1) In colon cancer, its dramatic down-regulation plays a potential role in the overexpression of sialyl Lewis antigens, increasing metastasis formation. 2) It is involved in the lytic function of murine cytotoxic T lymphocytes. 3) It prevents the development of muscular dystrophy in various dystrophic murine models, when overexpressed in muscular fibers. 4) It regulates the circulating half-life of the von Willebrand factor (vWf), determining the onset of a bleeding disorder in a murine model. The expression of the Sd(a) antigen has a wide impact on the physiology and the pathology of different biological systems. © 2013.

  2. Quasi-SU(3) truncation scheme for even-even sd-shell nuclei

    Vargas, C E; Draayer, J P


    The Quasi-SU(3) symmetry was uncovered in full pf and sdg shell-model calculations for both even-even and odd-even nuclei. It manifests itself through a dominance of single-particle and quadrupole-quadrupole terms in the Hamiltonian used to describe well-deformed nuclei. A practical consequence of the quasi-SU(3) symmetry is an efficient basis truncation scheme. In a recent work was shown that when this type of Hamiltonian is diagonalized in an SU(3) basis, only a few irreducible represntations (irreps) of SU(3) are needed to describe the Yrast band, the leading S = 0 irrep augmented with the leading S = 1 irreps in the proton and neutron subspaces. In the present article the quasi-SU(3) truncation scheme is used, in conjunction with a "realistic but schematic" Hamiltonian that includes the most important multipole terms, to describe the energy spectra and B(E2) transition strengths of 20-Ne, 22-Ne, 24-Mg and 28-Si. The effect of the size of the Hilbert space on both sets of observables is discussed, as well ...

  3. Developmental and Reproductive Toxicity of Soybean Isoflavones to Immature SD Rats



    Objective To investigate the dose-dependent toxic effect of soybean isoflavone extracts (SIE) on reproductive development in immature rats. Methods Growing male and female rats (n=50 each, 4 weeks) were divided into five groups fed with a standard cereal-based diet and gastrogavaged daily with 0, 30, 150, 300, and 600 mg SIE / kg body weight, respectively, for 12 weeks. Body weight, organ weights, and serum level of estrogen and testosterone were measured. Results Oral administration of SIE had no effect on food intake but decreased food efficiency ratio (P<0.01). Suppression on body weight gain by SIE was dose-dependent and the effect was greater on male than on female rats (P<0.01). SIE at high doses exhibited hepatotoxicity by increasing a relative liver weight, and also caused a smaller uterus but a greater relative ovary in female rats,while leading to larger relative testis and epididymis in male rats. SIE could decrease progesterone concentrations in female rats, whereas in male rats it reduced not only total testosterone level but also sperm count compared with the control group (P<0.05). Conclusion SIE at a range of 50-1000 times of human intake level affects not only growth but also development of reproductive system in growing rats.

  4. Effects of Extracellular ATP and Its Receptors on Peripheral Nerve Regeneration in SD Rats

    王栓科; 张致英; 洪光祥; 王同光; 王发斌; 康皓


    To explore the effect of the extracellular ATP and its receptors on axon regeneration in the sciatic nerve defect in rats, 0. 5 cm defect of the sciatic nerve was made and repaired with long arm silicon tube like a "Y" type. The single arm of the silicon tube was sutured to proximal of the sciatic nerve. 10μl 1 mmol/L ATP in physiological saline was injected into the left chamber of the silicon tube (experimental group) and physiological saline injected into another silicon tube as a control group. In another model 1 mmol/L 10 μl ATP and 1 mmol/L 10μl ATP+0.2 mg/ml suramin were injected respectively into two arms of the silicon tube. After 4 and 8 weeks the specimens were obtained from the silicon tube for examining the axon regeneration histologically and image analysis. All the regeneration axons grew into the silicon tube containing the ATP, but there was no axon regeneration in the silicon tube containing the ATP+Suramin or physiological saline. It was demonstrated that extracellular ATP had a powerful attraction to the regenerated axon of peripheral nerve. The suramin inhibited the axon induction of the extracellular ATP completely via the ATP receptors.

  5. Application design of clock chip SD2405 based on C8051F060%基于单片机C8051F060的时钟芯片SD2405应用设计



    本文介绍了时钟芯片SD2405的外部结构、内部数据寄存器定义以及寄存器的读写时序,同时给出了与单片机C8051F060硬件连接的设计方案及C语言程序设计。%This article describes the structure of the clock chip SD2405,the internal data registers and register read and write the definition of timing,and gives the design of the hardware connected with the microcontroller C8051F060 and C language programming.

  6. Dirac Coupled-channel Analyses of Polarized Proton Scatterings to the 2$^+$ Gamma Vibrational Band in $^{24}$Mg and $^{26}$Mg

    Shim, Sugie


    Dirac coupled channel calculations are performed phenomenologically for the high-lying excited states that belong to the 2$^+$ gamma vibrational band at the 800-MeV polarized proton inelastic scatterings from the s-d shell nuclei, $^{24}$Mg and $^{26}$Mg. Optical potential model is used and scalar and time-like vector potentials are considered as direct potentials. First-order vibrational collective models are used to obtain the transition optical potentials in order to accommodate the high-lying excited vibrational collective states. The complicated Dirac coupled channel equations are solved phenomenologically to reproduce the differential cross section and analyzing power data by varying the optical potential and deformation parameters. It is found that the relativistic Dirac coupled channel calculation could describe the high-lying excited states of the 2$^+$ gamma vibrational band at the 800-MeV polarized proton inelastic scatterings from s-d shell nuclei $^{24}$Mg and $^{26}$Mg reasonably well, showing b...

  7. Configuration of SoC FPGA, Booting of HPS and running Bare Metal Application from SD card.

    Zahid Rasheed, Awais


    First, a hardware design is created using Qsys in Quartus 16.0. Creation of the hardware design consists of configuring Hard Processor System (HPS) inside FPGA and adding necessary hardware blocks to the design. After generating the Qsys design, it is then instantiated in top level module in Verilog or VHDL. After setting up all pin assignments and adding all necessary files in the design, project is compiled to have a complete hardware design. Second part comprises full software design in correspondence with the hardware design and booting the HPS from SD card. Software includes enabling the different bridges used by HPS to communicate with FPGA, configuring FPGA from HPS and embedded application itself. Finally, everything is added in the SD card to get a complete automatic bare metal application running on the host board without any configuration what so ever.

  8. Simultaneous consideration of TQM and TPM influence on production performance: A case study on multicolor offset machine using SD Model

    Nagaraj H. Kamath


    Full Text Available An attempt is made in this research to show the relevance of System Dynamics (SD as a tool for simultaneously considering TQM and TPM environment in a offset machine of a commercial printing press. By controlling the TQM and TPM variables, this model will attempt to simulate or predict the behavior of an efficient printing operation. Identifying other scenarios pertaining to Human factors, affecting the socio-technical variables is the future research work of this paper. The practical implication concerns the efficient decision making system in multi-colour sheet feed offset printing, by controlling the socio-technical variables. This is a novel approach of combining different socio-technical variables SD and Cased based approach for obtaining a productive environment in print operation called “Total Production Management”.

  9. Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

    Moreno, Tomas A; O'Connell, Rachelle V; Chiu, Stephanie J; Farsiu, Sina; Cabrera, Michelle T; Maldonado, Ramiro S; Tran-Viet, Du; Freedman, Sharon F; Wallace, David K; Toth, Cynthia A


    To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults. SD-OCT images were obtained from 86 preterm infants, 59 term infants, and nine adults using a portable SD-OCT system plus nine adults using a tabletop system. An unprocessed image across the macula from one randomly selected eye of each participant was selected for determination of whether the choroidal-scleral junction (CSJ) could be visualized and for measurement of choroidal thickness. Subfoveal CSJ was visualized in 96% of young-preterm infants (imaged from 30-36 weeks postmenstrual age [PMA]); 78% of term-aged preterm infants (imaged from 37-42 weeks PMA); 49% of term infants; and 39% of adult subjects. Racial pigmentation did not affect CSJ visibility in young-preterm infants (P = 0.57). Subfoveal choroidal thickness (SFCT) in young-preterm infants, term-aged preterm infants, term infants, and adults was 176 ± 53 μm, 289 ± 92 μm, 329 ± 66 μm, and 258 ± 66 μm, respectively, and these were all statistically significantly different from one another except term-aged preterms to adults. Infant choroid can be imaged with a portable SD-OCT system without enhanced depth imaging. Melanin in the RPE and choroid does not hinder outer choroidal imaging in young-preterm infants without advanced retinopathy of prematurity (ROP). In preterm infants, choroidal thickness increased with age but was thinner when compared to term infants suggesting delayed development due to ROP.

  10. The Effect of Acid Stress Treatment on Viability and Membrane Fatty Acid Composition of Oenococcus oeni SD-2a

    ZHAO Wen-ying; LI Hua; WANG Hua; LI Zhong-chao; WANG Ai-lian


    To obtain ready-to-use wine malolactic starter cultures with high viability, the effects of acid stress treatments on the growth, inoculation viability, freeze-drying viability, and membrane fatty acid composition of the native Oenococcus oeni SD-2a strain were studied. The results showed that pH 3.5 and 3.2 adaptive treatments did not strongly decrease cell biomass but increased distinctly inoculation viability and freeze-drying viability. Concerning the membrane fatty acid composition, it was observed that acid stress conditions increased significantly the relative concentration of lactobacillic acid (C19cycl 1) and the unsaturated:saturated fatty acid ratio in cell membrane lipids. We assumed that acid-induced cross protective responses could be used in preparing ready-to-use O. oeni SD-2a malolactic starter cultures, and the accumulation of lactobacillic acid in the membrane of O. oeni SD-2a cells appears as an acid stress response mechanism,which might be related with the enhanced viability.

  11. Implementasi Kebijakan Pembelajaran Tematik Terpadu Kurikulum 2013 di SDN Kauman 1 Malang dan SD Muhammadiyah 1 Malang

    . Mulyadin


    Full Text Available Abstrak: Implementasi Kebijakan Pembelajaran Tematik Terpadu Kurikulum 2013 di SDN Kauman 1 Malang dan SD Muhammadiyah 1 Malang. Tujuan penelitian ini yaitu untuk mendeskripsikan dan menganalisis implementasi kebijakan pembelajaran tematik terpadu yang dilihat dari perencanaan pembelajaran, pelaksanaan pembelajaran, penilaian hasil pembelajaran, dan pengawasan pembelajaran di SDN Kauman 1 Malang dan SD Muhammadiyah 1 Malang. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif dan dibantu menggunakan data statistitik dengan rancangan penelitian deskriptif. Data dalam penelitian ini diambil dari hasil kuesioner dan wawancara pada responden dan observasi pelaksanaan pembelajarannya. Subjek penelitian ini adalah Kepala Sekolah, Wakil Kepala Sekolah Bidang Kurikulum dan Guru. Berdasarkan data hasil penelitian bahwa implementasi kebijakan pembelajaran tematik terpadu kurikulum 2013 di SDN Kauman 1 Malang dan SD Muhammadiyah 1 Malang sudah dikategorikan baik, hal ini dilihat dari aspek penguasaan, pemahaman dan kemampuan guru dalam proses perencanaan pembelajaran, pelaksanaan pembelajaran, dan penilaian hasil belajar begitupun pada proses pengawasan yang dilakukan oleh kepala sekolah sudah berjalan maksimal sesuai dengan tugas dan tanggung jawabnya seperti yang ada pada Peraturan Menteri Pendidikan dan Kebudayaan (Permendikbud Republik Indonesia Nomor 65 Tahun 2013 tentang Standar Proses Pendidikan Dasar dan Menengah. Kata Kunci: Implementasi, Pembelajaran Tematik Terpadu dan Kurikulum 2013

  12. Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma.

    Akbari, Abolfazl; Amanpour, Saeid; Muhammadnejad, Samad; Ghahremani, Mohammad Hossein; Ghaffari, Seyed Hamidollah; Dehpour, Ahmad Reza; Mobini, Gholam Reza; Shidfar, Fatemeh; Abastabar, Mahdi; Khoshzaban, Ahad; Faghihloo, Ebrahim; Karimi, Abbas; Heidari, Mansour


    Transforming growth factor-β (TGF-β) pathway is involved in primary tumor progression and in promoting metastasis in a considerable proportion of human cancers such as colorectal cancer (CRC). Therefore, blockage of TGF-β pathway signaling via an inhibitor could be a valuable tool in CRC treatment. To evaluate the efficacy of systemic targeting of the TGF-β pathway for therapeutic effects on CRC, we investigated the effects of a TGβRI (TGF-β receptor 1) or TβRI kinase inhibitor, SD-208, on SW-48, colon adenocarcinoma cells. In this work, in vitro cell proliferation was studied by methyl thiazolyl tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays. Also, the histopathological and immunohistochemical evaluations were conducted by hematoxylin and eosin, and Ki-67 and CD34 markers were stained, respectively. Our results showed no significant reduction in cell proliferation and vessel formation (170 ± 70 and 165 ± 70, P > 0.05) in treated SW-48 cells with SD-208 compared to controls. Our data suggested that SD-208 could not significantly reduce tumor growth and angiogenesis in human colorectal cancer model at least using SW-48 cells.

  13. Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium.

    Tianyi Zhang

    Full Text Available During animal development, accurate control of tissue specification and growth are critical to generate organisms of reproducible shape and size. The eye-antennal disc epithelium of Drosophila is a powerful model system to identify the signaling pathway and transcription factors that mediate and coordinate these processes. We show here that the Yorkie (Yki pathway plays a major role in tissue specification within the developing fly eye disc epithelium at a time when organ primordia and regional identity domains are specified. RNAi-mediated inactivation of Yki, or its partner Scalloped (Sd, or increased activity of the upstream negative regulators of Yki cause a dramatic reorganization of the eye disc fate map leading to specification of the entire disc epithelium into retina. On the contrary, constitutive expression of Yki suppresses eye formation in a Sd-dependent fashion. We also show that knockdown of the transcription factor Homothorax (Hth, known to partner Yki in some developmental contexts, also induces an ectopic retina domain, that Yki and Scalloped regulate Hth expression, and that the gain-of-function activity of Yki is partially dependent on Hth. Our results support a critical role for Yki- and its partners Sd and Hth--in shaping the fate map of the eye epithelium independently of its universal role as a regulator of proliferation and survival.

  14. Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium.

    Zhang, Tianyi; Zhou, Qingxiang; Pignoni, Francesca


    During animal development, accurate control of tissue specification and growth are critical to generate organisms of reproducible shape and size. The eye-antennal disc epithelium of Drosophila is a powerful model system to identify the signaling pathway and transcription factors that mediate and coordinate these processes. We show here that the Yorkie (Yki) pathway plays a major role in tissue specification within the developing fly eye disc epithelium at a time when organ primordia and regional identity domains are specified. RNAi-mediated inactivation of Yki, or its partner Scalloped (Sd), or increased activity of the upstream negative regulators of Yki cause a dramatic reorganization of the eye disc fate map leading to specification of the entire disc epithelium into retina. On the contrary, constitutive expression of Yki suppresses eye formation in a Sd-dependent fashion. We also show that knockdown of the transcription factor Homothorax (Hth), known to partner Yki in some developmental contexts, also induces an ectopic retina domain, that Yki and Scalloped regulate Hth expression, and that the gain-of-function activity of Yki is partially dependent on Hth. Our results support a critical role for Yki- and its partners Sd and Hth--in shaping the fate map of the eye epithelium independently of its universal role as a regulator of proliferation and survival.

  15. Applicability of a gene expression based prediction method to SD and Wistar rats: an example of CARCINOscreen®.

    Matsumoto, Hiroshi; Saito, Fumiyo; Takeyoshi, Masahiro


    Recently, the development of several gene expression-based prediction methods has been attempted in the fields of toxicology. CARCINOscreen® is a gene expression-based screening method to predict carcinogenicity of chemicals which target the liver with high accuracy. In this study, we investigated the applicability of the gene expression-based screening method to SD and Wistar rats by using CARCINOscreen®, originally developed with F344 rats, with two carcinogens, 2,4-diaminotoluen and thioacetamide, and two non-carcinogens, 2,6-diaminotoluen and sodium benzoate. After the 28-day repeated dose test was conducted with each chemical in SD and Wistar rats, microarray analysis was performed using total RNA extracted from each liver. Obtained gene expression data were applied to CARCINOscreen®. Predictive scores obtained by the CARCINOscreen® for known carcinogens were > 2 in all strains of rats, while non-carcinogens gave prediction scores below 0.5. These results suggested that the gene expression based screening method, CARCINOscreen®, can be applied to SD and Wistar rats, widely used strains in toxicological studies, by setting of an appropriate boundary line of prediction score to classify the chemicals into carcinogens and non-carcinogens.

  16. Orbital solutions of eight close sdB binaries and constraints on the nature of the unseen companions

    Geier, S; Heber, U; Kupfer, T; Maxted, P F L; Barlow, B N; Vuckovic, M; Tillich, A; Mueller, S; Edelmann, H; Classen, L; McLeod, A F


    The project Massive Unseen Companions to Hot Faint Underluminous Stars from SDSS (MUCHFUSS) aims at finding hot subdwarf stars (sdBs) with massive compact companions such as white dwarfs, neutron stars, or stellar-mass black holes. In a supplementary programme we obtained time-resolved spectroscopy of known hot subdwarf binary candidates. Here we present orbital solutions of eight close sdB binaries with orbital periods ranging from 0.1 to 10 days, which allow us to derive lower limits on the masses of their companions. Additionally, a dedicated photometric follow-up campaign was conducted to obtain light curves of the reflection-effect binary HS 2043+0615. We are able to constrain the most likely nature of the companions in all cases but one, making use of information derived from photometry and spectroscopy. Four sdBs have white dwarf companions, while another three are orbited by low-mass main sequence stars of spectral type M.

  17. Formation of Mg2Ni with enhanced kinetics: Using MgH2 instead of Mg as a starting material

    Zhao, Bin; Fang, Fang; Sun, Dalin; Zhang, Qingan; Wei, Shiqiang; Cao, Fenglei; Sun, Huai; Ouyang, Liuzhang; Zhu, Min


    At a temperature over the decomposition point (375 °C) of MgH2, the formation of Mg2Ni is greatly enhanced from the 2MgH2+Ni system, as compared to the 2Mg+Ni system. In support of this finding, in-situ observation of X-ray absorption fine structure of the two systems indicates that MgNi bonds form faster in the 2MgH2+Ni system than in the 2Mg+Ni system. Furthermore, theoretical modeling also shows that Mg atoms are readily released from MgH2 using much less energy and thus are more available to react with Ni once the dehydrogenation of MgH2 occurs, as compared to normal Mg.

  18. Thermodynamic modeling of the La-Mg-Y system and Mg-based alloys database

    DU Zhenmin; GUO Cuiping; LI Changrong; ZHANG Weijing


    As an example of the La-Mg-Y system, the method how to set up the thermodynamic model of individual phases was introduced in the process of thermodynamic optimization. The solution phases (liquid, body-centered cubic,face-centered cubic, hexagonal close-packed and double hexagonal close-packed) were modeled with the Redlich-Kister equation. The compound energy model has been used to describe the thermodynamic functions of the intermetallic compounds in the La-Mg-Y systems. The compounds Mg2Y, Mg24Y5, Mg12La, Mg17La2, Mg41La5, Mg3La and Mg2La in the La-Mg-Y system were treated as the formulae (Mg, Y)2(La,Mg, Y), Mg24(La,Mg, Y)4Y, Mg12(La, Y), Mg17(La, Y)2,Mg41(La,Y)5, Mg3(La,Mg,Y) and Mg2(La,Y), respectively. A model (La,Mg,Y)0.5(La,Mg,Y)0.5 was applied to describe the compound MgM formed by MgLa and MgY in order to cope with the order-disorder transition between body-centered cubic solution (A2) and MgM with CsCl-type structure (B2) in the La-Mg-Y system. The Gibbs energies of individual phases were optimized in the La-Mg, La-Y and La-Mg-Y systems by CALPHAD technique. The projection of the liquidus surfaces for the La-Mg-Y system was predicted. The Mg-based alloys database including 36 binary and 15 ternary systems formed by Mg, Al, Cu, Ni, Mn, Zn and rare earth elements was set up in SGTE standard.

  19. Improved efficacy of intramuscular weekly administration of clodronate 200 mg (100 mg twice weekly) compared with 100 mg (once weekly) for increasing bone mineral density in postmenopausal osteoporosis.

    Frediani, Bruno; Bertoldi, Ilaria; Pierguidi, Serena; Nicosia, Antonella; Picerno, Valentina; Filippou, Georgios; Cantarini, Luca; Galeazzi, Mauro


    Clodronate is a bisphosphonate used for the treatment of postmenopausal osteoporosis and all conditions characterized by excess bone resorption. We have previously reported that intramuscular (IM) therapy with clodronate at a dose of 100 mg/week displays significant effects on bone mineral density (BMD) although a plateau effect is observed after 1 year of treatment. Previous reports indicate that the densitometric effects of bisphosphonates directly correlate with the drug dosage and suggest that using IM clodronate at doses higher than 100 mg/week may result in improved efficacy. However, to the best of our knowledge, this has never been proved. The primary endpoint of the study was the effect on BMD of IM clodronate 100 mg once weekly or 100 mg twice weekly in patients with postmenopausal osteoporosis. The incidence of non-traumatic vertebral fractures and adverse events was also reported. The present study was a randomized, open-label, parallel-group trial conducted between January 2007 and December 2009 in the Osteoporosis and Osteoarticular Instrumental Diagnosis Centre (University of Siena, Siena, Italy). The study involved 60 women, aged 57-78 years, with a history of postmenopausal osteoporosis for more than 5 years. Patients were randomized to receive IM clodronate 100 mg once weekly (Group A, 30 patients) or 100 mg twice weekly (Group B, 30 patients), for 2 years. Significant increases compared with baseline in BMD were observed for both groups at 1 and 2 years, with significantly higher increases for Group B compared with Group A. Group B displayed a BMD increase (± SD) at the lumbar spine of +4.0 % (± 2.1) and +5.9 % (± 2.0) at 1 and 2 year(s), respectively, compared with +2.8 % (± 1.7) and +3.5 % (± 2.2), respectively, observed for Group A. Similarly, Group B showed better performance compared with Group A for BMD increase at the femoral neck, with an observed increase of +3.5 % (± 1.7) and +5.4 % (± 1.8) at 1 and 2 year(s), respectively

  20. Lipid peroxidation in the kidney of rats treated with V and/or Mg in drinking water.

    Scibior, Agnieszka; Zaporowska, Halina; Niedźwiecka, Irmina


    LPO induced by in vitro treatment of kidney supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between exogenous Fe (Fe(exog)) and endogenous V (V(end)) and between V(end) and exogenous V (V(exog)). In conclusion, V (as NaVO(3)) consumed by the rats with drinking water at a dose of 12.9 mg V kg(-1) b.w. per 24 h for 12 weeks increased the basal LPO and markedly enhanced TAS in the renal tissue. Its pro-oxidant potential was also found in in vitro conditions. The Mg dose (6 mg Mg kg(-1) b.w. per 24 h) ingested by the rats together with V (12.7 mg V kg(-1) b.w. per 24 h) neither reduced nor intensified the spontaneous LPO, compared with V-only intoxicated animals; however, the stimulating effect of Mg on LPO was revealed in in vitro conditions.

  1. Trigonometric Parallaxes for Two Late-Type Subdwarfs: LSR1425+71 (sdM8.0) and the Binary LSR1610-00 (sd?M6pec)

    Dahn, C C; Levine, S E; Tilleman, T; Monet, A K B; Stone, R C; Guetter, H H; Canzian, B; Pier, J R; Hartkopf, W I; Liebert, J; Cushing, M


    Trigonometric parallax astrometry and BVI photometry are presented for two late-type subdwarf candidates, LSR1425+71 (sdM8.0) and LSR1610-00 (sd?M6pec). For the former we measure an absolute parallax of 13.37+/-0.51 mas yielding Mv=15.25+/-0.09. The astrometry for LSR1610-00 shows that this object is an astrometric binary with a period of 1.66+/-0.01 yr. The photocentric orbit is derived from the data; it has a moderate eccentricity (e ~ 0.44+/-0.02) and a semi-major axis of 0.28+/-0.01 AU based on our measured absolute parallax of 31.02+/-0.26 mas. Our radial velocity measure of -108.1+/-1.6 km/s for LSR1610-00 at epoch 2006.179, when coupled with the observation of -95+/-1 km/s at epoch 2005.167 by Reiners & Basri, indicates a systemic radial velocity of -101+/-1 km/s for the LSR1610-00AB pair. The galactic velocity components for LSR1425+71 and LSR1610-00AB -- (U,V,W)=(84+/-6, -202+/-13, 66+/-14) km/s and (U,V,W)=(36+/-2, -232+/-2, -61+/-2) km/s, respectively. For both stars, the velocities are charact...

  2. Ca, Mg, Zn, Fe, Cu and Mn content of ass’s milk

    Elisabetta Salimei


    Full Text Available The aim of this study was to determine Ca, Mg, Zn, Fe, Cu and Mn content of ass’s milk. Twenty four individual milk samples were collected from 4 lactating asses. During the experi- mental period milk samples were collected every 3 weeks interval, using a milking machine; asses were housed with the foals that were separated from the jennets 3 hours before milking. Milk was analysed for Ca, Mg, Zn, Fe, Cu and Mn content by atomic absorption spectrometry. The concentration mean (±SD of Ca Mg, Zn, Fe, and Cu were respectively 334.61±39.80, 58.46±8.43, 1.99±0.51, 1.15±0.52, 0.16±0.06 mg/kg. Mn was found only at trace level. Iron content of ass’s milk was the most variable ranging from 0.43 to 1.88 mg/kg. Correlation coefficients were positive and significant between Ca and Mg (r=0.63, Zn and Mg (r=0.45, Zn and Fe (r=0.49 and Zn and Cu (r=0.50. In this study, except for Fe, mean concentration of Ca, Mg, Zn, and Cu in ass’s milk was similar to those reported in literature for human milk.

  3. A Review of Mg Isotope Analytical Methods by MC-ICP-MS

    Yajun An; Fang Huang


    Application of multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) has led to big breakthrough of analytical methods for metal stable isotopes, resulting in rapid progresses in non-traditional stable isotope geochemistry. As a new geological tracer, Mg isotopes have been widely applied in studies of almost all important disciplines of geochemistry. High precision Mg isotope data measured by MC-ICP-MS are now available with precision about 0.05‰ amu-1 (2SD) or better. Because mass bias caused by chemical procedure and instrument can easily cause significant analytical error, it is still a challenge to obtain accurate Mg isotope data for natural samples. In this paper, we systematically review the development of analytical technique of Mg isotopes, with a detailed description of a series of important techniques used in the measurement process, including calibration of instrumental mass-bias, chemical purification process, matrix effect, and pitfalls for high precision isotope analyses. We compare standard data from different labs and establish a guideline for Mg iso-tope analysis procedure. Additionally, we briefly discuss the behaviors of Mg isotopes during geological processes including equilibrium and kinetic Mg isotope fractionations, such as magma differentiation, chemical and thermal diffusion, and continental weathering. Finally, we propose some future prospects for Mg isotope geochemistry in both high and low temperature geological processes.

  4. K2 observations of the pulsating subdwarf B star EQ Piscium: an sdB+dM binary

    Jeffery, C S


    K2, the two-wheel mission of the Kepler space telescope, observed the pulsating subdwarf B star EQ Psc during engineering tests in 2014 February. In addition to a rich spectrum of g-mode pulsation frequencies, the observations demonstrate a light variation with a period of 19.2 h and a full amplitude of 2%. We suggest that this is due to reflection from a cool companion, making EQ\\,Psc the longest-period member of some 30 binaries comprising a hot subdwarf and a cool dwarf companion (sdB+dM), and hence useful for exploring the common-envelope ejection mechanism in low-mass binaries.

  5. Prenylated Indolediketopiperazine Peroxides and Related Homologues from the Marine Sediment-Derived Fungus Penicillium brefeldianum SD-273

    Chun-Yan An


    Full Text Available Three new indolediketopiperazine peroxides, namely, 24-hydroxyverruculogen (1, 26-hydroxyverruculogen (2, and 13-O-prenyl-26-hydroxyverruculogen (3, along with four known homologues (4–7, were isolated and identified from the culture extract of the marine sediment-derived fungus Penicillium brefeldianum SD-273. Their structures were determined based on the extensive spectroscopic analysis and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of compounds 1–3 was determined using chiral HPLC analysis of their acidic hydrolysates. Each of the isolated compounds was evaluated for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina lethality.

  6. The achievement of market study on a representative sample of companies in Romania about SD and CSR communication

    Mihaela Bucur


    Full Text Available The purpose of this paper is to provide some results on how firms in Romania made communication on Corporate Social Responsibility (CSR and sustainable development (SD. The paper identifies the real pulse of Romanian business on the premise of communication responsible. Our approach shows how communication is performed inside and outside the company, the issues of CSR in the world customers, suppliers, business partners and customers. The findings demonstrate where are communication problems which components are satisfied through communication and where there should be improvements.


    Dyah Worowirastri Ekowati


    Full Text Available Educational assessment standards were prepared in order to complete the assessment standards. This study aims to describe the ability of teachers in assessment of thematic learning. Based on the results of the research, which shows the performance evaluation based on the curriculum 2013, has not been fully implemented by Shanta 1 SD Negeri Malang and MI Nurul Islam sub district of Tajinan. The obtained data will be very useful for determining measures or policies relating to the assessment standards, which in turn is expected to improve the quality of the school.   Keywords: Assessment, Thematic Learning

  8. The NPOESS Preparatory Project Science Data Segment (SDS) Data Depository and Distribution Element (SD3E) System Architecture

    Ho, Evelyn L.; Schweiss, Robert J.


    The National Polar-orbiting Operational Environmental Satellite System (NPOESS) Preparatory Project (NPP) Science Data Segment (SDS) will make daily data requests for approximately six terabytes of NPP science products for each of its six environmental assessment elements from the operational data providers. As a result, issues associated with duplicate data requests, data transfers of large volumes of diverse products, and data transfer failures raised concerns with respect to the network traffic and bandwidth consumption. The NPP SDS Data Depository and Distribution Element (SD3E) was developed to provide a mechanism for efficient data exchange, alleviate duplicate network traffic, and reduce operational costs.

  9. Preparation and Hydrogen Storage Properties of Mg-Rich Mg-Ni Ultrafine Particles

    Jianxin Zou


    Full Text Available In the present work, Mg-rich Mg-Ni ultrafine powders were prepared through an arc plasma method. The phase components, microstructure, and hydrogen storage properties of the powders were carefully investigated. It is found that Mg2Ni and MgNi2 could be obtained directly from the vapor state reactions between Mg and Ni, depending on the local vapor content in the reaction chamber. A nanostructured MgH2 + Mg2NiH4 hydrogen storage composite could be generated after hydrogenation of the Mg-Ni ultrafine powders. After dehydrogenation, MgH2 and Mg2NiH4 decomposed into nanograined Mg and Mg2Ni, respectively. Thermogravimetry/differential scanning calorimetry (TG/DSC analyses showed that Mg2NiH4 phase may play a catalytic role in the dehydriding process of the hydrogenated Mg ultrafine particles.

  10. Effects of the direct light in the surface detectors (SD) of the Pierre Auger Observatory and their change in time

    Esquipula, Pedro Alfonso Valencia; Salomé Caballero Mora, Karen


    Cosmic Rays (CR) are particles which come to the earth from Universe. Their origin and production mechanisms are still unknown. The Pierre Auger Observatory is located in Mendoza, Argentina. It is dedicated to the study of CR. When CR arrive to the earth’s atmosphere they produce a shower of secondary particles called air shower. The surface detector (SD) of the Pierre Auger Observatory consists of tanks full of pure water, where CR produce Cherenkov radiation, when going through them. This light is detected by three photomultiplier tubes (PMT) located on the top of each tank. Depending of the angle of arrival direction of the primary CR, each PMT is able to register different signal than the other. The goal of this study is to look at these effects of direct light on the PMT’s to explore if they change in time. The obtained results may give information about the physical status of the tanks in order to monitor the work of the SD, and to estimate possible systematic effects on the measurements. The current results of this study are shown.

  11. Three-dimensional Expansion: In Suspension Culture of SD Rat's Osteoblasts in a Rotating Wall Vessel Bioreactor



    Objective To study large-scale expansion of SD (Sprague-Dawley) rat's osteoblasts in suspension culture in a rotating wall vessel bioreactor (RWVB). Methods The bioreactor rotation speeds were adjusted in the range of 0 to 20 rpm,which could provide low shear on the microcarriers around 1 dyn/cm2. The cells were isolated via sequential digestions of neonatal (less than 3 days old) SD rat calvaria. After the primary culture and several passages, the cells were seeded onto the microcarriers and cultivated in T-flask, spinner flask and RWVB respectively. During the culture period, the cells were counted and observed under the inverted microscope for morphology every 12 h. After 7 days, the cells were evaluated with scanning electron microscope (SEM) for histological examination of the aggregates. Also, the hematoxylin-eosin (HE) staining and alkaline phosphatase (ALP) staining were performed. Moreover, von-Kossa staining and Alizarin Red S staining were carried out for mineralized nodule formation. Results The results showed that in RWVB, the cells could be expanded by more than ten times and they presented better morphology and vitality and stronger ability to form bones. Conclusions The developed RWVB can provide the culture environment with a relatively low shear force and necessary three-dimensional (3D)interactions among cells and is suitable for osteopath expansion in vitro.

  12. Production and Characterization of Alkaline Protease from a High Yielding and Moderately Halophilic Strain of SD11 Marine Bacteria

    Hongxia Cui


    Full Text Available A marine bacterium SD11, which was isolated from sea muds (Geziwo Qinhuangdao Sea area, China, was used to produce thermostable alkaline serine nonmetal protease in the skim milk agar plate medium with 10% NaCl. The optimal temperature about the manufacture of the extracellular protease was ~60°C. The crude enzyme was stable at 20–50°C. The activity was retained to 60% and 45% after heating for 1 h at 60 and 70°C, respectively. The protease was highly active in a wide pH scope (8.0–10.0 and maximum protease activity exhibited at pH 10.0. The activity was restrained by phenylmethylsulfonyl fluoride (PMSF but mildly increased (~107% in the presence of ethylenediaminetetraacetic acid (EDTA, indicating that the production contains serine-protease(s and nonmetal protease(s. Moreover, the crude alkaline protease was active with the 5 mM Ca2+, Mn2+, Zn2+, Cu2+, Na+, and K+ that existed separately. In addition, the protease showed superduper stability when exposed to an anionic surfactant (5 mM SDS, an oxidizing agent (1% H2O2, and several organic solvents (methanol, isopropanol, and acetone. These results suggest that the marine bacterium SD11 is significant in the industry from the prospects of its ability to produce thermally stable alkaline protease.

  13. Pattern of inner retinal layers involvement in pigmented paravenous retinochoroidal atrophy as determined by SD-OCT: case report.

    Junqueira, Daniela Laura Melo; Lopes, Flavio Siqueira Santos; Biteli, Luís Gustavo; Prata, Tiago Santos


    Pigmented paravenous retinochoroidal atrophy is an ocular disease characterized by outer retina and choroidal atrophy often with overlying intraretinal bone spicule pigment deposition along the retinal veins. As a rare condition, there is scant information in the literature regarding the pattern of inner retinal layers involvement. We present a case of a 41-year-old white man initially referred for a glaucoma evaluation. Fundoscopy revealed patches of retinochoroidal atrophy and light pigmentation extending from the optic nerve head along the inferior-temporal retinal veins in both eyes. Using different spectral-domain optical coherence tomography (SD-OCT) protocols we identified a significant thinning of the inner retinal layers along the inferior-temporal veins, but with a lucid interval surrounding the optic nerve head. Standard automated perimetry revealed a superior absolute arcuate scotoma sparing the central fixation (good structure-functional correlation). This pattern of inner retinal layers involvement was not previously described. We believe SD-OCT added significantly to the anatomical description of this case. Physicians should consider these new anatomical findings and correlate them with functional status while assessing these patients.


    Navneet Saxena


    Full Text Available BACKGROUND The purpose of this study is to compare central foveal thickness (CFT of patients preoperatively and postoperatively cataract surgery using SD- optical coherence tomography and to correlate CFT with vision. MATERIALS AND METHODS 200 eyes of 100 patients were examined and two groups were formed. Group-A was considered as the control group in the study and eyes in group-B were operated for cataract using SICS technique. The central foveal thickness (CFT in each group was measured using SD-OCT machine (Cirrus Zeiss preoperatively, postoperatively on day 1, week 1 and after 1 month and the data was compiled and compared. RESULTS OCT detected increased central foveal thickness postoperatively on day 1 and weeks 2 but this returned to preoperative levels in one month. It was also seen that preoperative BCVA was poor (0.53± 0.12 Snellen approx. 6/24. Improvement in BCVA was seen in postoperative day-1, week 2 and 1 month. CONCLUSION This study shows that preoperative CFT values were minimal which increased on postoperatively but returned to preoperative values at one month after surgery BCVA was poorer preoperatively due to cataract but improved as CFT decreased with time.

  15. Pattern of inner retinal layers involvement in pigmented paravenous retinochoroidal atrophy as determined by SD-OCT: case report

    Daniela Laura Melo Junqueira


    Full Text Available Pigmented paravenous retinochoroidal atrophy is an ocular disease characterized by outer retina and choroidal atrophy often with overlying intraretinal bone spicule pigment deposition along the retinal veins. As a rare condition, there is scant information in the literature regarding the pattern of inner retinal layers involvement. We present a case of a 41-year-old white man initially referred for a glaucoma evaluation. Fundoscopy revealed patches of retinochoroidal atrophy and light pigmentation extending from the optic nerve head along the inferior-temporal retinal veins in both eyes. Using different spectral-domain optical coherence tomography (SD-OCT protocols we identified a significant thinning of the inner retinal layers along the inferior-temporal veins, but with a lucid interval surrounding the optic nerve head. Standard automated perimetry revealed a superior absolute arcuate scotoma sparing the central fixation (good structure-functional correlation. This pattern of inner retinal layers involvement was not previously described. We believe SD-OCT added significantly to the anatomical description of this case. Physicians should consider these new anatomical findings and correlate them with functional status while assessing these patients.

  16. Survival of free and microencapsulated human-derived oral probiotic Lactobacillus paracasei SD1 in orange and aloe vera juices

    Rawee Teanpaisan


    Full Text Available Microencapsulation was evaluated as a means of preserving Lactobacillus paracasei SD1, a human-derived strain with probiotic potential, in orange and aloe vera juices. The microencapsulation parameters included alginate concentration, calcium chloride concentration and hardening-time, and the efficacy of microencapsulation to preserve the survival of microencapsulated bacteria compared to free cells during exposure in fruit juices were determined. The results revealed that the viable count of free-cell form markedly decreased compared to microencapsulated form. The microencapsulation of 2% alginate (w/v and 0.05 M CaCl2 gave the best result to preserve the probiotic. It was found that viability of microencapsulated probiotic bacteria was significantly higher than free-cell in fruit juices during 8 weeks of storage time in the refrigerator. The potential probiotic trait related to inhibitory effect was not affected after microencapsulation process. In summary, the microencapsulation method may be an alternative way of preserving the viability of probiotic L. paracasei SD1.


    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...


    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  19. Highly (100) oriented MgO growth on thin Mg layer in MTJ structure

    Jimbo, K [Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1-S3-42 O-okayama, Meguro, Tokyo 152-8552 (Japan); Nakagawa, S, E-mail:


    In order to apply Stress Assisted Magnetization Reversal (SAMR) method to perpendicular magnetoresistive random access memory (p-MRAM) with magnetic tunnel junction (MTJ) using MgO (001) oriented barrier layer, multilayer of Ta/ Terfenol-D/ Mg/ MgO and Ta/ Terfenol-D/ MgO were prepared. While the MgO layer, deposited directly on the Terfenol-D layer, did not show (100) orientatin, very thin metallic Mg layer, deposited prior to the MgO deposition, was effective to attain MgO (100) orientation. The crystalline orientation was very weak without Mg, however, the multilayer with Mg showed very strong MgO(100) peak and the MgO orientation was shifted depending on the Mg thickness.

  20. Fabrication and superconducting properties of internal Mg diffusion processed MgB2 wires using MgB4 precursors

    Xu, Da; Wang, Dongliang; Yao, Chao; Zhang, Xianping; Ma, Yanwei; Oguro, Hidetoshi; Awaji, Satoshi; Watanabe, Kazuo


    Monofilament MgB2/Nb/Monel wires were fabricated using three different MgB4 precursors by an internal Mg diffusion (IMD) process. The wire geometry and heat-treatment conditions were optimized in order to improve the critical current density (J c) of the MgB2 wire. The influences of the quality of MgB4 powders, such as the particle size and MgO impurity, on the microstructure and superconducting properties of the wires were discussed. Although there were small amounts of voids, unreacted MgB4 particles and MgO impurity existed in the superconducting layers, and the transport layer J c of the wire with the MgB4 precursor reached 3.0 × 104 A cm-2 at 4.2 K and 10 T, which was comparable to that of IMD-processed wires fabricated using boron precursors. Both the non-barrier J c and engineering J c of MgB2 wire made using a MgB4 precursor were enhanced due to the improved grain connectivity and the enlarged fill factor.

  1. Determination of the 36Mg(n ,γ )37Mg reaction rate from Coulomb dissociation of 37Mg

    Shubhchintak; Chatterjee, R.; Shyam, R.


    We use the Coulomb dissociation (CD) method to calculate the rate of the 36Mg(n ,γ )37Mg radiative capture reaction. The CD cross sections of the 37Mg nucleus on a 208Pb target at the beam energy of 244 MeV/nucleon, for which new experimental data have recently become available, were calculated within the framework of a finite-range distorted-wave Born approximation theory that is extended to include the projectile deformation effects. Invoking the principle of detailed balance, these cross sections are used to determine the excitation function and subsequently the rate of the 36Mg(n ,γ )37Mg reaction. We compare these rates to those of the 36Mg(α ,n )39Si reaction calculated within a Hauser-Feshbach model. We find that for T9 as large as up to 1.0 (in units of 109 K) the 36Mg(n ,γ )37Mg reaction is much faster than the 36Mg(α ,n )39Si one. The inclusion of the effects of 37Mg projectile deformation in the breakup calculations enhances the (n ,γ ) reaction rate even further. Therefore, it is highly unlikely that the (n ,γ )β -decay r -process flow will be broken at the 36Mg isotope by the α process.

  2. Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion.

    Kim, Ji Eun; Go, Jun; Sung, Ji Eun; Lee, Hyun Ah; Yun, Woo Bin; Hong, Jin Tae; Hwang, Dae Youn


    Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in constipation has yet to be established. Therefore, in this study, we investigated the laxative effects of Urd on chronic constipation. The constipation phenotypes and their related mechanisms were investigated in the transverse colons of SD rats with loperamide (Lop)-induced constipation after treatment with 100 mg/kg of Urd. The number, weight and water contents of stools were significantly higher in the Lop + Urd treated group than the Lop + Vehicle treated group, while food intake and water consumption of the same group were maintained at a constant level. The thickness of the mucosa layer, muscle and flat luminal surface, as well as the number of goblet cells, paneth cells and lipid droplets were enhanced in the Lop + Urd treated group. Furthermore, the expression of the muscarinic acetylcholine receptors M2 and M3 (mAChR M2 and M3) at the transcriptional and translational level was recovered in the Lop + Urd treated group, while some markers such as Gα and inositol triphosphate (IP3) in their downstream signaling pathway were completely recovered by Urd treatment. Moreover, the ability for mucin secretion and the expression of membrane water channel (aquaporine 8, AQP8) were increased significantly in the Lop + Urd treated group compared with Lop + Vehicle treated group. Finally, the activity of Urd was confirmed in primary smooth muscle of rat intestine cells (pRISMC) based on Gα expression and IP3 concentration. The results of the present study provide the first strong evidence that Urd can be considered an important candidate for improving chronic constipation induced by Lop treatment in animal models.

  3. Gallotannin-Enriched Extract Isolated from Galla Rhois May Be a Functional Candidate with Laxative Effects for Treatment of Loperamide-Induced Constipation of SD Rats

    Kim, Ji Eun; Go, Jun; Koh, Eun Kyoung; Song, Sung Hwa; Sung, Ji Eun; Lee, Hyun Ah; Lee, Young Hee; Hong, Jin Tae; Hwang, Dae Youn


    Several natural products containing tannins are used as traditional medicines for treatment of constipation; however, their pharmacological mechanism is not well understood. The laxative effects of gallotannin-enriched extract isolated from Galla Rhois (GEGR) were investigated using a constipation model induced by loperamide (Lop) injection. After analysis for antioxidant activity of GEGR, alterations in the excretion parameters, histological structure, mucin secretion, and related protein levels were measured in the transverse colon of Sprague Dawley (SD) rats with Lop-induced constipation following treatment with 250, 500 and 1,000 mg/ml of GEGR. The number and weight of feces increased significantly by 48–79% and 128–159%, respectively, in the Lop+GEGR treated group relative to the Lop+vehicle treated group, while food intake and water consumption were maintained at a constant level. The thickness of mucosa, muscle and flat luminal surface, as well as the number of goblet cells and crypt of lieberkuhn were enhanced in the Lop+GEGR treated group. Moreover, mucin secretion increased significantly in a dose dependent manner in the Lop+GEGR treated group. Furthermore, the downstream signaling pathway of the muscarinic acetylcholine receptors (mAChR) M2 and M3 was recovered by GEGR treatment, although the expression level varied. The levels of Gα expression and inositol triphosphate (IP3) concentration were also recovered in the Lop+GEGR treated group relative to the Lop+vehicle treated group. The results of the present study provide strong evidence that tannins distributed in various medicinal plants are important candidates for improving chronic constipation induced by Lop treatment in animal models. PMID:27618438

  4. The coordination of Mg in foraminiferal calcite

    Branson, Oscar; Redfern, Simon A. T.; Tyliszczak, Tolek; Sadekov, Aleksey; Langer, Gerald; Kimoto, Katsunori; Elderfield, Henry


    The Mg/Ca ratio of foraminiferal calcite is a widely accepted and applied empirical proxy for ocean temperature. The analysis of foraminifera preserved in ocean sediments has been instrumental in developing our understanding of global climate, but the mechanisms behind the proxy are largely unknown. Analogies have been drawn to the inorganic precipitation of calcite, where the endothermic substitution of Mg for Ca is favoured at higher temperatures. However, evidence suggests that foraminiferal Mg incorporation may be more complex: foraminiferal magnesium is highly heterogeneous at the sub-micron scale, and high Mg areas coincide with elevated concentrations of organic molecules, Na, S and other trace elements. Fundamentally, the incorporation mode of Mg in foraminifera is unknown. Here we show that Mg is uniformly substituted for Ca within the calcite mineral lattice. The consistency of Mg-specific X-ray spectra gathered from nano-scale regions across the shell (‘test’) reveals that the coordination of Mg is uniform. The similarity of these spectra to that produced by dolomite shows that Mg is present in an octahedral coordination, ideally substituted for Ca in a calcite crystal structure. This demonstrates that Mg is heterogeneous in concentration, but not in structure. The degree of this uniformity implies the action of a continuous Mg incorporation mechanism, and therefore calcification mechanism, across these compositional bands in foraminifera. This constitutes a fundamental step towards a mechanistic understanding of foraminiferal calcification processes and the incorporation of calcite-bound palaeoenvironment proxies, such as Mg.

  5. Modeling and stabilities of Mg/MgH2 interfaces: A first-principles investigation

    Tang, Jia-Jun; Yang, Xiao-Bao; Chen, Li-Juan; Zhao, Yu-Jun


    We have theoretically investigated the modeling and the structural stabilities of various Mg/MgH2 interfaces, i.e. Mg(10bar 10)/MgH2(210), Mg(0001)/MgH2(101) and Mg(10bar 10)/MgH2(101), and provided illuminating insights into Mg/MgH2 interface. Specifically, the main factors, which impact the interfacial energies, are fully considered, including surface energies of two phases, mutual lattice constants of interface model, and relative position of two phases. The surface energies of Mg and MgH2, on the one hand, are found to be greatly impacting the interfacial energies, reflected by the lowest interfacial energy of Mg(0001)/MgH2(101) which is comprised of two lowest energy surfaces. On the other hand, it is demonstrated that the mutual lattice constants and the relative position of two phases lead to variations of interfacial energies, thus influencing the interface stabilities dramatically. Moreover, the Mg-H bonding at interface is found to be the determinant of Mg/MgH2 interface stability. Lastly, interfacial and strain effects on defect formations are also studied, both of which are highly facilitating the defect formations. Our results provide a detailed insight into Mg/MgH2 interface structures and the corresponding stabilities.

  6. Modeling and stabilities of Mg/MgH2 interfaces: A first-principles investigation

    Jia-Jun Tang


    Full Text Available We have theoretically investigated the modeling and the structural stabilities of various Mg/MgH2 interfaces, i.e. Mg(101¯0/MgH2(210, Mg(0001/MgH2(101 and Mg(101¯0/MgH2(101, and provided illuminating insights into Mg/MgH2 interface. Specifically, the main factors, which impact the interfacial energies, are fully considered, including surface energies of two phases, mutual lattice constants of interface model, and relative position of two phases. The surface energies of Mg and MgH2, on the one hand, are found to be greatly impacting the interfacial energies, reflected by the lowest interfacial energy of Mg(0001/MgH2(101 which is comprised of two lowest energy surfaces. On the other hand, it is demonstrated that the mutual lattice constants and the relative position of two phases lead to variations of interfacial energies, thus influencing the interface stabilities dramatically. Moreover, the Mg-H bonding at interface is found to be the determinant of Mg/MgH2 interface stability. Lastly, interfacial and strain effects on defect formations are also studied, both of which are highly facilitating the defect formations. Our results provide a detailed insight into Mg/MgH2 interface structures and the corresponding stabilities.

  7. Different impacts of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116.

    Song, Xiaojin; Tan, Yanzhen; Liu, Yajun; Zhang, Jingtao; Liu, Guanglei; Feng, Yingang; Cui, Qiu


    Aurantiochytrium is an important docosahexaenoic acid (DHA) producer containing two kinds of fatty acid synthesis pathways, that is, the fatty acid synthase pathway (FAS) for saturated fatty acid synthesis and the polyketide synthase pathway (PKS) for polyunsaturated fatty acid synthesis. To understand the regulation mechanism between the two pathways, the impacts of six short-chain fatty acids on the fatty acid synthesis of Aurantiochytrium sp. SD116 were studied. All short-chain fatty acids showed little effect on the cell growth, but some of them significantly affected lipid accumulation and fatty acid composition. Pentanoic acid and isovaleric acid greatly inhibited the synthesis of saturated fatty acids, whereas the polyunsaturated fatty acid synthesis was not affected. Analysis of malic enzyme activity, which supplied NADPH for saturated fatty acids biosynthesis, indicated that the two fatty acid synthesis pathways can utilize different substrates and possess independent sources of NADPH.

  8. [Effect of low-intensity ultrasound on endothelin-1 and nitrogen monoxide in uterine tissues of SD rats following abortion].

    Zhang, Yanxia; Guo, Jufang; Lin, Chuan; Lu, Lu; Li, Chengzhi


    To investigate the effect of low-intensity ultrasound on the contents of endothelin (ET-1) and nitrogen monoxide (NO) in uterine tissues of SD rats after abortion. Thirty female pregnant rats were randomly divided into treatment group and control group and received mifepristone and misoprostol to induce abortion. The rats in the treatment group were treated by low-intensity ultrasound for 30 min/day for 5 consecutive days, and those in the control group received sham treatment. The uterine tissue was then taken and homogenized for measurement of ET-1 and NO contents using enzyme-linked immunosorbent assay and chemical testing. ET-1 content in the uterine tissues was significantly higher in the treatment group than in the control group (P0.05). Low-intensity ultrasound can promote the contraction of uterine smooth muscles by increasing the level of ET-1 to modulate the homeostasis of ET-1 and NO.

  9. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118

    Shang, Zhuo; Li, Xiaoming; Meng, Li; Li, Chunshun; Gao, Shushan; Huang, Caiguo; Wang, Bingui


    Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X ( 1), and 14 other known compounds comprising three steroids ( 2-4), two ceramides ( 5 and 6), six aromatic compounds ( 7-12), and three alkaloids ( 13-15). Xanthocillin X ( 1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X ( 1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin ( 15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X ( 1).

  10. Transportation Structure Analysis Using SD-MOP in World Modern Garden City: A Case Study in China

    Jiuping Xu


    Full Text Available The idea of the “garden city” was developed theoretically to offer solutions to serious city development problems such as traffic congestion, population, and environmental pollution, among which the transportation is considered the most important. The question is how to develop balanced transportation in a garden city. Transportation is a complex system, particularly in a garden city. Therefore, we establish a new approach named the transportation multiobjective optimization system dynamics  (SD-MOP model, which firstly calculates the optimal proportion of different transport means with an MOP approach and then applies them to the dynamic transportation system to analyze the results and analyze the influence on the whole system using different transportation means variation. In this paper, we take Chengdu as an example, one of the few cities in the world declared as building a garden city, and then develop some recommendations about world modern garden city transportation system development.

  11. Theoretical study of structure and production of F19Λ as a gateway to sd-shell hypernuclei

    Umeya, Atsushi; Motoba, Toshio


    Energy level structures of the typical light sd-shell hypernucleus F19Λ, together with 18F, have been studied in detail with the multi-configuration shell model. Both positive-parity and negative-parity nuclear core excitations are fully taken into account by removing the spurious center-of-mass excitation effects. Corresponding to the J-PARC proposal of the 19F (K- ,π- γ) F19Λ experiment, the production cross sections have been estimated extensively, including the angular distributions. Starting with the elementary amplitudes for the K- n → Λπ- process, the microscopic DWIA calculations at high energy kaon momenta up to 1.8 GeV / c have been carried out for the first time. The calculated wave functions are also used to estimate the electromagnetic transition probabilities for both 18F and F19Λ. The detailed γ-decay schemes are presented and discussed.

  12. Perceptions Analysis on Service Delivery (SD using ITIL version 3 framework in Ministerio Da Justica Ministry Dili Timor Leste

    Edio Da Costa


    Full Text Available Service Delivery (SD is a managerial of the processes that have a primary focus on the user of all Information System (IS and Information Technology (IT services, which ensures that IS and IT services can be used according as the function to support the activities in the public institutions. The purpose of this study was to determine the extent to which the strategic development of IS and IT services that have been implemented in accordance with the strategic plan towards the implementation of IT Governance. The results of this study indicate that significantly the Ministerio da Justia Dili Timor Leste (MJTL has implemented policies and standard operation procedures (SOP relating to the framework of Information Technology Infrastructur Library (ITIL version 3, although it is not maximized and extended throughout the unit, it is because lack of human resources, staffing and financial aspects.

  13. Safety assessment for electricity generation failure accident of gas cooled nuclear power plant using system dynamics (SD) method

    Woo, Tae Ho [Seoul National Univ. (Korea, Republic of). Dept. of Nuclear Engineering


    The power production failure happens in the loss of coolant of the nuclear power plants (NPPs). The air ingress is a serious accident in gas cooled NPPs. The quantification of the study performed by the system dynamics (SD) method which is processed by the feedback algorithms. The Vensim software package is used for the simulation, which is performed by the Monte-Carlo method. Two kinds of considerations as the economic and safety properties are important in NPPs. The result shows the stability of the operation when the power can be decided. The maximum value of risk is the 11.77 in 43rd and the minimum value is 0.0 in several years. So, the success of the circulation of coolant is simulated by the dynamical values. (orig.)

  14. Complex risk analysis for loss of electric power in liquid metal nuclear reactor by system dynamics (SD) method

    Woo, Tae Ho [Seoul National Univ. (Korea, Republic of). Dept. of Nuclear Engineering


    The power stabilization of the nuclear power plants (NPPs) is investigated in the aspect of the liquid metal coolant. The quantification of the risk analysis is performed by the system dynamics (SD) method which is processed by the feedback and accumulation complex algorithms. The Vensim software package is used for the simulations, which is supported by the Monte-Carlo method. There are 2 kinds of considerations as the economic and safety properties. The result shows the stability of the operations when the power can be decided. This shows the higher efficiency of the reactor. The failure frequency is 16/60 = 27%. In the event of Power Stabilized, the failure event is in the quite lower frequency rate. The commercial use of the reactor is important in the operations. (orig.)

  15. Análise de crescimento em Heteranthera reniformis, sob diferentes teores de Ca, Mg e S Growth analysis in Heteranthera reniformis under different contents of Ca, Mg and S

    Vanessa David Domingos


    Full Text Available O objetivo deste trabalho foi estudar o crescimento, alocação de biomassa e teores de nutrientes em Heteranthera reniformis Ruiz & Pav., sob o efeito de diferentes concentrações de Ca, Mg e S. As plantas foram cultivadas em vasos plásticos preenchidos com pedra rolada, em soluções nutritivas a 80% da concentração original de Sarruge, correspondente à solução-base. O experimento foi desenvolvido em delineamento experimental inteiramente casualizado, com quatro teores (0%, 25%, 50% e 75% da solução base de 80% avaliados em Ca, Mg e S, além da testemunha (solução-base, com quatro repetições no período de 35 dias em casa de vegetação. O aumento dos teores de Ca na solução propiciou uma redução significativa na área foliar. As maiores áreas foliares ocorreram em soluções a 25% de Ca e 50% de Mg e S. A maior proporção de biomassa seca está no caule, exceto a 25% de Ca (40 mg L-1 que propiciou maior área foliar e área foliar específica. Entre os teores de Mg na solução, as maiores biomassas foram observadas a 50% de Mg (19,2 mg.L-1 e, para o S, não houve diferenças significativas, exceto a 0%. A solução com 160 mg L-1 de Ca propiciou maior concentração de Ca na folha (56,6 g kg-1. Os teores de Ca, Mg e S em solução corresponderam a um aumento proporcional na planta. Os teores de enxofre nas folhas e nos caules aumentaram com a concentração de S na solução, enquanto o teor nas raízes reduziu nas concentrações entre 12,8 e 38,4 mg.L-1.The objective was to study the growth, biomass allocation and concentration of nutrients in Heteranthera reniformis Ruiz & Pav. under the effect of different concentrations of Ca, Mg and S. The plants were cultivated in plastic pots fulfilled with rolled stone, in nutrient solutions of 80% of the original concentration of Sarruge. The experiment was carried out in a complete randomized design, with 4 contents (0, 25, 50 and 75% of the base solution evaluated in Ca, Mg and


    Risha Maysara


    Full Text Available Liver is one of the most important organ for drug metabolism in the body. The damage to the liver can be marked by increased activity of the enzyme alanine aminotransferase (ALT in the blood. Lycopene is an antioxidant that has the ability to eliminate free radicals and detoxifies electrophilic compounds that damage can be prevented. The purpose of this research is to know whether lycopene can inhibit the increase alanine aminotransferase activity of SD (Sprague Dawley rats induced by parasetamol. This experiment using 20 male rats Sprague Dawley. They were divided into 4 groups. Group I is a healthy control (baseline was only given aquadest, group II were given paracetamol as pain control, group III and IV are treatment group were each given lycopene with a dosage 15 µg/kg BW and 30 µg/kg BW for 21 days. On 19th day group II, as well as all treatment groups induced paracetamol. The blood sampling was performed on orbital sinus on 19th day (before induced by paracetamol and on 21th day or two days after induced paracetamol to know the difference alanine aminotransferase activity. The data were analyzed using non-parametric statistical methods with Kruskal-Wallis test followed by Mann-Whitney test with 95% confidence level. The result has showed that the lycopene doses 15 µg/kgBW had alanine aminotransferase activity of 130.10 ± 11.83 U/I and lycopene doses 30 µg/kgBW had alanine aminotransferase activity of 106.46 ± 2.36 U/I. If compared with paracetamol control had alanine aminotransferase activity of 92.53 ± 2.57 U/I, should take a summary that the lycopene doses 15 ìg/kg BW and 30 ìg/kg BW couldn’t decrease alanine aminotransferase activity on SD (Sprague Dawley male rats.

  17. Corrosion behavior of Mg and Mg-Zn alloys in simulated body fluid

    GAO Jia-cheng; WU Sha; QIAO Li-ying; WANG Yong


    The corrosion behavior of Mg and Mg-Zn in simulated body fluid was studied.The mass loss of pure Mg,Mg-Zn-Zr and Mg-Zn-Zr-Y in simulated body fluid was measured using photovoltaic scale meter.Corrosion rate was determined through electrochemical tests.Finally,the corrosion mechanism was tbermodynamically studied.The results show that the corrosion rate decreases with the lapse of time for both pure Mg and Mg alloys.The purer the alloy,the borer the corrosion resistance exhibits.The corrosion behavior of Mg alloy is improved by the addition of trace Y.

  18. Kebiasaan jajan dan pola makan serta hubungannya dengan status gizi anak usia sekolah di SD Sonosewu Bantul Yogyakarta

    Kurnia Noviani


    Full Text Available ABSTRACTBackground: Elementary school children are in the developmental age, thus need nutritions with good and proper quality and quantity. Nutrient needs can be fulfilled through eating habits. Snacking habit can also contribute to nutritional status in children if the snack consumed has good quality in term of the typeand quantity.Objectives: To understand the relationship between snacking habit and diet with nutritional status of elementary school children in SD Sonosewu Bantul Yogyakarta.Methods: This study was an observational research with cross sectional approach. This study population was all students in SD Sonosewu Bantul Yogyakarta grades III, IV, V, that were 160 respondents. The sample used in this study was 65 people selected by using simple random sampling. The process ofselecting a random sample was based on the random number table. The research instruments used were questionnaires, form of 24 -hour food recall for 1 day, bathroom scales, and microtoise. The collected data was analyzed by using a statistical test chi-square.Results: Respondents who had frequent snacking habit with a normal nutritional status was 27 respondents (81%, whereas those who had less frequent snacking habit with wasting nutritional status was 7 respondents (21.9%. Respondents with a good diet (>80% RDA with wasting nutritional status was 9 respondents (75% and respondents who had bad diet with normal nutritional status was 34 respondents (66%. Chi-Square analysis in the relationship between snacking habit and nutritional status obtained 0.781 p value (p>0.05 which mean that there was no statistically significant of relationship between snacking habits and child’s nutritional status. Whereas Chi-Square analysis of diet and nutritional status showed a significant relationship with 0.008 p value (p<0.05 means that there was a relationship between diet and nutritional status.Conclusions: There was a relationship between diet and nutritional

  19. 基于 SOPC 和 SD 卡的嵌入式存储系统设计与实现



      本文介绍了一种基于 Nios II SOPC 系统和 SD 卡的嵌入式存储系统的实现方案,构建了基于 Nios II 软核处理器的 SD 卡读写操作系统,编写了软件驱动程序,实现了对 SD 卡读写的基本操作。

  20. Non-resonant microwave absorption studies of superconducting MgB2 and MgB2 + MgO

    Janhavi P Joshi; Subhasis Sarangi; A K Sood; Dilip Pal; S V Bhat


    Non-resonant microwave absorption (NRMA) studies of superconducting MgB2 and a sample containing ∼ 10% by weight of MgO in MgB2 are reported. The NRMA results indicate near absence of intergranular weak links in the pure MgB2 sample. A linear temperature dependence of the lower critical field c1 is observed indicating a non- wave superconductivity. However, the phase reversal of the NRMA signal which could suggest wave symmetry is also not observed. In the MgB2 + MgO sample, much larger low field dependent absorption is observed indicating the presence of intergranular weak links. The hysteretic behavior of NRMA is compared and contrasted in the two samples. In the pure MgB2 sample, a large hysteresis is observed between the forward and the reverse scans of the magnetic field indicating strong pinning of flux lines. This hysteresis saturates a few degrees below c while in the MgB2 + MgO sample, a much slower increase of hysteresis with decreasing temperature is observed, a signature of weaker pinning.

  1. The conduction bands of MgO, MgS and HfO2

    Boer, P.K. de; Groot, R.A. de


    Electronic structure calculations for MgO, MgS and HfO2 are reported. It is shown that the conduction bands of MgO and MgS have predominantly anion character, contrary to the common picture of the conduction band being derived from cation states. In transition metal oxides, unoccupied anion states a

  2. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.

    Voets, T.; Nilius, B.; Hoefs, S.J.G.; Kemp, J.W.C.M. van der; Droogmans, G.; Bindels, R.J.M.; Hoenderop, J.G.J.


    Mg2+ is an essential ion involved in a multitude of physiological and biochemical processes and a major constituent of bone tissue. Mg2+ homeostasis in mammals depends on the equilibrium between intestinal Mg2+ absorption and renal Mg2+ excretion, but little is known about the molecular nature of

  3. Comparison of the Abilities of SD-OCT and SS-OCT in Evaluating the Thickness of the Macular Inner Retinal Layer for Glaucoma Diagnosis.

    Kyoung Min Lee

    Full Text Available To compare the abilities of spectral-domain optical coherence tomography (OCT (SD-OCT; Spectralis, Heidelberg Engineering and swept-source OCT (SS-OCT; DRI-OCT1 Atlantis system, Topcon for analyzing the macular inner retinal layers in diagnosing glaucoma.The study included 60 patients with primary open-angle glaucoma (POAG and 60 healthy control subjects. Macular cube area was scanned using SD-OCT and SS-OCT on the same day to assess the thicknesses of the macular retinal nerve fiber layer (mRNFL, ganglion cell layer plus inner plexiform layer (GCIPL, and total retinal layer in nine subfields defined by the Early Treatment Diabetic Retinopathy Study (ETDRS. The abilities of the parameters to discriminate between the POAG and control groups were assessed using areas under the receiver operating characteristic curves (AUCs.Glaucoma-associated mRNFL and GCIPL thinning was more common in the outer zones than inner zones for both SD-OCT and SS-OCT. The mRNFL and GCIPL measurements showed distinct pattern differences between SD-OCT and SS-OCT in each ETDRS subfield. Although the glaucoma-diagnosis ability was comparable between SD-OCT and SS-OCT for most of the parameters, AUC was significantly larger for SD-OCT measurements of the GCIPL thickness in the outer temporal zones (p = 0.003 and of the mRNFL thickness in the outer nasal zones (p = 0.001, with the former having the largest AUC for discriminating POAG from healthy eyes (AUC = 0.894.Spectralis SD-OCT and DRI SS-OCT have similar glaucoma-diagnosis abilities based on macular inner layer thickness analysis. However, Spectralis SD-OCT was potentially superior to DRI SS-OCT in detecting GCIPL thinning in the outer temporal zone, where the glaucomatous damage predominantly occurs.

  4. Color Doppler ultrasound detection of uterine artery S/D, PI and RI in patients with preeclampsia and their correlation with disease severity

    Yan-Ping Zhao


    Objective:To study color Doppler ultrasound detection of uterine artery S/D, PI and RI in patients with preeclampsia and their correlation with disease severity.Methods:Pregnant women with preeclampsia were selected as PE group, healthy pregnant women were the NOR group, color Doppler ultrasound detection was conducted to detect uterine artery S/D, PI and RI, serum was collected to detect the contents of angiogenesis-related cytokines, and placenta tissue was collected to detect the contents of proteases as well as inhibitors, oxidative stress molecules and anti-apoptotic molecules.Results: S/D, PI and RI of PE group were significantly higher than those of NOR group; serum PIGF, VEGF and PAPP-A contents of PE group were significantly lower than those of NOR group and negatively correlated with S/D, PI and RI while sVEGFR-1 and Kisspeptin-10 contents were significantly higher than those of NOR group and positively correlated with S/D, PI and RI; CTSB, CTSL, MMP3, MMP9, SOD, GST, VitC, VitE and coenzyme Q10 as well as Xiap and Survivin contents in placenta tissue of PE group were lower than those of NOR group and negatively correlated with S/D, PI and RI while TIMP1, TIMP2, TIMP3 and RECK contents were higher than those of NOR group and positively correlated with S/D, PI and RI.Conclusion: Uterine artery S/D, PI and RI significantly increase in patients with preeclampsia, and can assess the angiogenesis, cell invasion, anti-apoptosis and oxidative stress in patients.

  5. Supercontinuum generation in nonlinear fibers using high-energy figure-of-eight mode-locked fiber laser for SD-OCT application

    Xu, Bo; Nagata, Tsubasa; Yamashita, Shinji


    Generation of flat and broadband supercontinum is demonstrated in an all fiber system using the high-energy noise-like pulses from a stable figure-of-eight fiber laser and nonlinear fibers. This SC source is successfully applied to the spectral domain optical coherence tomography (SD-OCT). The axial resolution is significantly improved compared with the case of the superluminescent diode source. SD-OCT imaging is also demonstrated.

  6. Hydrogen storage systems from waste Mg alloys

    Pistidda, C.; Bergemann, N.; Wurr, J.; Rzeszutek, A.; Møller, K. T.; Hansen, B. R. S.; Garroni, S.; Horstmann, C.; Milanese, C.; Girella, A.; Metz, O.; Taube, K.; Jensen, T. R.; Thomas, D.; Liermann, H. P.; Klassen, T.; Dornheim, M.


    The production cost of materials for hydrogen storage is one of the major issues to be addressed in order to consider them suitable for large scale applications. In the last decades several authors reported on the hydrogen sorption properties of Mg and Mg-based systems. In this work magnesium industrial wastes of AZ91 alloy and Mg-10 wt.% Gd alloy are used for the production of hydrogen storage materials. The hydrogen sorption properties of the alloys were investigated by means of volumetric technique, in situ synchrotron radiation powder X-ray diffraction (SR-PXD) and calorimetric methods. The measured reversible hydrogen storage capacity for the alloys AZ91 and Mg-10 wt.% Gd are 4.2 and 5.8 wt.%, respectively. For the Mg-10 wt.% Gd alloy, the hydrogenated product was also successfully used as starting reactant for the synthesis of Mg(NH2)2 and as MgH2 substitute in the Reactive Hydride Composite (RHC) 2LiBH4 + MgH2. The results of this work demonstrate the concrete possibility to use Mg alloy wastes for hydrogen storage purposes.

  7. Coherent interface structures and intergrain Josephson coupling in dense MgO/Mg2Si/MgB2 nanocomposites

    Ueno, Katsuya; Nagashima, Yukihito; Seto, Yusuke; Matsumoto, Megumi; Sakurai, Takahiro; Ohta, Hitoshi; Takahashi, Kazuyuki; Uchino, Takashi


    Many efforts are under way to control the structure of heterointerfaces in nanostructured composite materials for designing functionality and engineering application. However, the fabrication of high-quality heterointerfaces is challenging because the crystal/crystal interface is usually the most defective part of the nanocomposite materials. In this work, we show that fully dense insulator (MgO)/semiconductor(Mg2Si)/superconductor(MgB2) nanocomposites with atomically smooth and continuous interfaces, including epitaxial-like MgO/Mg2Si interfaces, are obtained by solid phase reaction between metallic magnesium and a borosilicate glass. The resulting nanocomposites exhibit a semiconductor-superconducting transition at 36 K owing to the MgB2 nanograins surrounded by the MgO/Mg2Si matrix. This transition is followed by the intergrain phase-lock transition at ˜24 K due to the construction of Josephson-coupled network, eventually leading to a near-zero resistance state at 17 K. The method not only provides a simple process to fabricate dense nanocomposites with high-quality interfaces, but also enables to investigate the electric and magnetic properties of embedded superconducting nanograins with good intergrain coupling.

  8. The Coordination of Mg in Foraminiferal Calcite

    Branson, O.; Redfern, S. A.; Tyliszczak, T.; Sadekov, A.; Langer, G.; Elderfield, H.


    The Mg/Ca ratio in calcite shells ('tests') of foraminifera is an empirical ocean temperature proxy widely used to interpret palaeoclimates. We explore the distribution and local environment of Mg in foram tests using STXM and NEXAFS spectroscopy to test the fundamental assumptions behind the proxy, and shed light on the mechanisms underpinning this vital oceanographic tool. Throughout the development of the Mg/Ca proxy, it has been assumed that Mg in foraminifera tests substitutes directly into the calcite lattice (1). This assumption is based on XRD analyses of various high-Mg biogenic carbonates, where Mg concentrations are manifest in the shifted position of diffraction peaks (2, 3). The extrapolation of this trend to foraminiferal calcite links the proxy to inorganic precipitation experiments, and provides a theoretical mechanistic framework to understand the link between Mg/Ca and temperature: the substitution of Mg is endothermic, and favoured at higher temperatures. However, the concentration of Mg in most foraminifera (0-10 mmol/mol Mg/Ca) is below the detection limit of XRD methods, and the analogy to inorganic systems has not been explicitly tested. Electron microprobe (4-6), LA-ICP-MS (7) and high-resolution nanoSIMS mapping (Sadekov, unpub.) of foraminifera tests have revealed the presence of high 'trace element' bands running in plane with the test surface, enriched in Mg, Sr, S, organic molecules and other trace elements. This emphasises a key question highlighted by Dodd (1) when the proxy was still in its infancy: how is Mg incorporated into mineral skeletons? By direct substitution into the calcite lattice, interstitially in a separate distinct mineral phase, or associated with organic compounds? We address this fundamental question using scanning transmission X-ray microscopy (STXM) and X-ray absorption spectroscopy at ALS beamline 11.0.2 to examine the distribution and local atomic environment of Mg in two contrasting species of foraminifera

  9. OD(X/sup 2/II) and SD(X/sup 2/II) from reactions of D atoms with OCS under bulk and precursor geometry limited conditions

    Haeusler, D.; Rice, J.; Wittig, C.


    Reactions of D atoms with OCS were studied by 193-nm pulsed laser photolysis of DBr as a nearly monoenergetic D-atom source. Nascent OD(X/sup 2/II) and SD(X/sup 2/II) rotational, vibrational, spin-orbit, and ..lambda..-doublet populations were obtained under single-collision bulk conditions at 300 K. The SD channel is favored energetically ( H = -43 +/- 13 and 230 +/- 13 kJ mol/sup -1/ for the SD and OD channels, respectively) and is the dominant pathway ((SD)/(OD) = 5 +/- 2). Nascent OD(X/sup 2/II) products were also obtained from a precursor geometry limited (PGL) reaction by using the weakly bound van der Waals complex SCO-DBr. The OD(X/sup 2/II) rotational distributions are the same for both bulk and PGL conditions and can be reproduced by using a statistical model. Due to experimental difficulties, SD(X/sup 2/II) distributions could not be obtained under PGL conditions. The SD(X/sup 2/II) distribution obtained under bulk conditions is very nonstatistical, suggesting that this species is not formed via a long-lived DSCO intermediate complex in which vibrational energy is randomized.

  10. Ectopic expression of Capsicum-specific cell wall protein Capsicum annuum senescence-delaying 1 (CaSD1) delays senescence and induces trichome formation in Nicotiana benthamiana.

    Seo, Eunyoung; Yeom, Seon-In; Jo, Sunghwan; Jeong, Heejin; Kang, Byoung-Cheorl; Choi, Doil


    Secreted proteins are known to have multiple roles in plant development, metabolism, and stress response. In a previous study to understand the roles of secreted proteins, Capsicum annuum secreted proteins (CaS) were isolated by yeast secretion trap. Among the secreted proteins, we further characterized Capsicum annuum senescence-delaying 1 (CaSD1), a gene encoding a novel secreted protein that is present only in the genus Capsicum. The deduced CaSD1 contains multiple repeats of the amino acid sequence KPPIHNHKPTDYDRS. Interestingly, the number of repeats varied among cultivars and species in the Capsicum genus. CaSD1 is constitutively expressed in roots, and Agrobacterium-mediated transient overexpression of CaSD1 in Nicotiana benthamiana leaves resulted in delayed senescence with a dramatically increased number of trichomes and enlarged epidermal cells. Furthermore, senescence- and cell division-related genes were differentially regulated by CaSD1-overexpressing plants. These observations imply that the pepper-specific cell wall protein CaSD1 plays roles in plant growth and development by regulating cell division and differentiation.

  11. Characterization of Asia 1 sdAb from camels bactrianus (C. bactrianus and conjugation with quantum dots for imaging FMDV in BHK-21 cells.

    Shuanghui Yin

    Full Text Available Foot-and-mouth disease (FMD, caused by FMD virus (FMDV, is a highly contagious viral disease affecting cloven-hoofed animals. Camelids have a unique immunoglobulin profile, with the smallest functional heavy-chain antibodies (sdAb or VHH naturally devoid of light chains with antigen-binding capacity. We screened and characterized five sdAbs against FMDV by immunized library from C. bactrianus with Asia 1 virus-like particles (VLPs. Three of five recombinant sdAbs were stably expressed in E.coli, remained highly soluble, and were serotype-specific for VP1 protein of FMDV Asia 1 by ELISA. These failed to completely neutralize the Asia 1 virus. According to the KD value of binding affinity to three sdAbs, which ranged from 0.44 to 0.71 nm by SPR, sdAb-C6 was selected and conjugated with Zn/CdSe quantum dots (QDs to form a QDs-C6 probe, which was used to trace and image the subcellular location of FMDV in BHK-21 cells. The results show that FMD virions were observed from 3 h.p.i., and most of virions were distributed on one side of the nucleus in the cytoplasm. We demonstrate the utility of sdAbs as functionalized QDs are powerful tools for FMDV research.

  12. Effect of Long-Term Consumption of Lactobacillus paracasei SD1 on Reducing Mutans streptococci and Caries Risk: A Randomized Placebo-Controlled Trial

    Rawee Teanpaisan


    Full Text Available Background: A previous study revealed Lactobacillus paracasei SD1, a probiotic strain, could reduce mutans streptococci (MS. The aim of this study was to evaluate the long-term effects of L. paracasei SD1 on the colonization of MS, and whether caries lesions developed. Methods: After informed consent, 122 children were recruited and randomly assigned to the probiotic or control groups. The probiotic group received milk-powder containing L. paracasei SD1 and the control group received standard milk-powder once daily for six months. Salivary MS and lactobacilli were enumerated using differential culture at baseline and at three-month intervals for 12 months. The persistence of L. paracasei SD1 was investigated using AP-PCR for DNA-fingerprinting. Oral health was examined at baseline and at the end of the study according to WHO criteria. Results: The long-term consumption could prolong colonization of L. paracasei SD1. Significantly reduced MS counts and increased lactobacilli levels were found among children in the probiotic group. There were less caries lesions in the probiotic group at the end of the study. A significant reduction of the development of new caries lesions (4.5 times was observed in the high caries risk group but not in the low caries risk group. Conclusions: Results demonstrate that the long-term daily ingestion of the human-derived probiotic L. paracasei SD1 significantly reduces the number of MS and caries risk in the high caries group.

  13. Isolation of a rice endophytic bacterium, Pantoea sp. Sd-1, with ligninolytic activity and characterization of its rice straw degradation ability.

    Xiong, X Q; Liao, H D; Ma, J S; Liu, X M; Zhang, L Y; Shi, X W; Yang, X L; Lu, X N; Zhu, Y H


    This study focused on an endophytic bacterial strain, Pantoea sp. Sd-1, which can be used to degrade lignin and rice straw. This strain was isolated from rice seeds by an optimized surface sterilization method. Pantoea sp. Sd-1 showed exceptional ability to degrade rice straw and lignin. In rice straw or kraft lignin-containing medium supplemented with 1% glucose and 0.5% peptone, Pantoea sp. Sd-1 effectively reduced the rice straw mass weight by 54.5% after 6 days of treatment. The strain was also capable of reducing the lignin colour (52.4%) and content (69.1%) after 4 days of incubation. The findings suggested that the rice endophytic bacterium Pantoea sp. Sd-1 could be applied for the degradation of lignocellulose biomass, such as rice straw. Rice straw, an abundant agricultural by-product in China, is very difficult to degrade because of its high lignin content. Due to the immense environmental adaptability and biochemical versatility of bacteria, endophytic bacteria are useful resources for biodegradation. In this study, we screened for endophytic bacteria capable of biodegrading rice straw and lignin and obtained one strain, Pantoea sp. Sd-1, with suitable characteristics. Sd-1 could be used for degradation of rice straw and lignin, and may play an important role in biodegradation of this agricultural by-product. © 2013 The Society for Applied Microbiology.

  14. Identifikasi Carrier Bakteri Streptococcus β hemolyticus Group A pada Murid SD Negeri 13 Padang Berdasarkan Perbedaan Umur dan Jenis Kelamin

    Fadhila Aini


    Full Text Available AbstrakStreptococcus β hemolyticus Grup A atau yang disebut juga Streptococcus pyogenes merupakan salah satu bakteri patogen yang banyak menginfeksi manusia.Bakteri ini dapat ditemukan sebagai carrier di saluran pernafasan terutama pada anak-anak, tidak menimbulkan penyakit tetapi berisiko untuk menyebarkan penyakit. Tujuan penelitian ini adalah menentukan jumlah carrier  bakteri Streptococcus β hemolyticus Grup A pada murid berdasarkan perbedaan umur dan jenis kelamin. Jenis penelitian ini adalah deskriptif cross-sectional dengan menggunakan sampel seluruh murid SD Negeri 13 Padang. Hasil penelitian adalah didapatkan 2 orang murid yang menderita carrier, yaitu pada kelompok usia>8-9 tahun dan >11 tahun. Berdasarkan jenis kelamin yang terdiri dari 54 orang laki-laki dan 50 orang perempuan, didapatkan 2 orang carrier yaitu hanya pada anak laki-laki. Hasil penelitian menunjukkan bahwa carrier bakteri Streptococcus β hemolyticus Group  A terdapat pada anak usia tersebut karena masih kurangnya pengetahuan tentang kebersihan. Carrier yang ditemukan hanya pada anak laki-laki kemungkinan disebabkan mereka lebih sering bermain di luar rumah dan terpapar dengan berbagai bakteri patogen dan kurang memperhatikan kebersihan diri.Kata kunci: carrier, streptococcus β hemolyticus grup A, umur, jenis kelamin AbstractGroup A Streptococcus β hemolyticus or also called Streptococcus pyogenes is one of many pathogenic bacteria that infect humans. These bacteria can be found as a carrier in the respiratory tract especially in children, do not cause disease but can be a risk for spreading the disease. This objective of this study was to determine the amount of the carrier of bacteria group A Streptococcus β hemolyticus based on age and gender differences. This research is a descriptive cross - sectional study using a sample of all students of SD Negeri 13 Padang. Based on the age of 104 students found that students who suffer 2 carrier, which is in the age

  15. Hubungan Status Sosial Ekonomi dan Gaya Hidup dengan Kejadian Obesitas pada Siswa SD Negeri 08 Alang Lawas Padang

    Cici Octari


    Full Text Available AbstrakObesitas di Indonesia mulai menjadi masalah gizi masyarakat walaupun gizi kurang masih tinggi. Obesitas disebabkan oleh banyak faktor/multifaktorial yang dapat dibagi menjadi genetik dan lingkungan yang diantaranya adalah status sosial ekonomi dan gaya hidup. Penelitian ini menggunakan desain cross sectional study dengan populasi adalah seluruh siswa kelas I sampai V di SD N 08 Alang Lawas,Padang. Penelitian ini mendapatkan hasil 8,21% siswa mengalami obesitas, 11,79% overweight atau gemuk, 82,60% tingkat pendapatan orang tua siswa berada di atas garis kemiskinan, 71,30% ayah dan 71,80% ibu siswa memiliki tingkat pendidikan menengah, 58,50% siswa memiliki pola makan baik, dan 60% memiliki aktifitas fisik aktif. Tidak didapatkan hubungan yang bermakna antara kejadian obesitas dengan tingkat pendidikan orang tua (ayah: p=0,205 ; ibu: p=1,00, tingkat pendapatan orang tua (p=0,396, dan pola makan anak (p=0,245. Didapatkan hubungan yang bermakna antara aktifitas fisik anak dengan kejadian obesitas (p=0,048.Kata kunci: obesitas, anak, sosial-ekonomi, gaya hidupAbstractIn Indonesia, obesity has became a public nutrition problem although frequence of undernutrition was still high. The obesity caused by many factor/multifactorial that asssigned to genetic factor and environment factor. Two of the environment factors are social-economy and life style. Cross sectional study was chosen as a method to conduct the study. The study population were all the students on 1st grade to 5th grade in SD Negeri 08 Alang Lawas, Padang. The result shows that 8.21% of the students suffered from obesity, 11.79% were overweight, 82.60% of the students have the parents that have income more then the poverty line, 71.30% of the fathers and 71.80% of the mothers were middle graduations, 58.50% have good consumptions pattern, and 60% have active physical activity. There are no association between the obesity among the children with parent’s graduation (father: p=0

  16. Existing form and effect of zirconium in pure Mg, Mg-Yb, and Mg-Zn-Yb alloys

    YU Wenbin; HE Hong; LI Chunmei; LI Qing; LIU Zhiyi; QIN Bing


    The existing form and grain refining effects of small zirconium addition in pure Mg, Mg-Yb and Mg-Zn binary alloys, and Mg-Zn-Yb ternary alloy (ZK60-Yb) were investigated. The results show that Zr element exists mainly in single and cluster particles of pure α-Zr or Zn-Zr compounds inside grains and at grain boundaries. Only the particles located in the interior of grains can act as the nucleus for α-Mg growth and effectively promote the formation of Fine equiaxed grains. The broken and dispersed Zr-rich particles produced during the hot extrusion process can form nebulous banded structure in which these free particles may act as obstacles to dislocation motion in wrought magnesium alloys.

  17. Proton-proton correlations observed in two-proton decay of $^{19}$Mg and $^{16}$Ne

    Mukha, I; Sümmerer, K; Acosta, L; Alvarez, M A G; Casarejos, E; Chatillon, A; Cortina-Gil, D; Espino, J; Fomichev, A; García-Ramos, J E; Geissel, H; Gómez-Camacho, J; Hofmann, J; Kiselev, O; Korsheninnikov, A; Kurz, N; Litvinov, Yu; Martel, I; Nociforo, C; Ott, W; Pfützner, M; Rodriguez-Tajes, C; Roeckl, E; Stanoiu, M; Weick, H; Woods, P J


    Proton-proton correlations were observed for the two-proton decays of the ground states of $^{19}$Mg and $^{16}$Ne. The trajectories of the respective decay products, $^{17}$Ne+p+p and $^{14}$O+p+p, were measured by using a tracking technique with microstrip detectors. These data were used to reconstruct the angular correlations of fragments projected on planes transverse to the precursor momenta. The measured three-particle correlations reflect a genuine three-body decay mechanism and allowed us to obtain spectroscopic information on the precursors with valence protons in the $sd$ shell.


    Novan Ardy Wiyani


    Full Text Available This qualitative research study is intended to determine the steps in Planning Moral Education Program (PMEP based on Total Quality Management (TQM at SD Islam Al-Irsyad 02 Purwokerto. Hopefully, the results of this study can be used as a guideline by Islamic elementary school in implementing TQM-based PMEP as preventive measures to address the moral crisis today. The data in this study were collected by using interview techniques and documentation. The data has been collected and analyzed using inductive data analysis techniques. Based on the research results, it was obtained findings that there are four steps involved in planning TQM-based PMEP. First, developing a vision and mission of the school in favor of the PMEP. Second, preparing the quality assurance character and accomplishments with PMEP. Third, developing standards of competence homeroom teachers to support the implementation of PMEP. Fourth, preparing Standard Operating Procedure (SOP of learners’ morals value to support the implementation of the PMEP.

  19. An sd(2) hybridized transition-metal monolayer with a hexagonal lattice: reconstruction between the Dirac and kagome bands.

    Zhou, Baozeng; Dong, Shengjie; Wang, Xiaocha; Zhang, Kailiang; Mi, Wenbo


    Graphene-like two-dimensional materials have garnered tremendous interest as emerging device materials due to their remarkable properties. However, their applications in spintronics have been limited by the lack of intrinsic magnetism. Here, we perform an ab initio simulation on the structural and electronic properties of several transition-metal (TM) monolayers (TM = Cr, Mo and W) with a honeycomb lattice on a 1/3 monolayer Cl-covered Si(111) surface. Due to the template effect from the halogenated Si substrate, the TM-layers will be maintained in an expanded lattice which is nearly 60% larger than that of the freestanding case. All these isolated TM-layers exhibit ferromagnetic coupling with kagome band structures related to sd(2) hybridization and a strong interfacial interaction may destroy the topological bands. Interestingly, the W-monolayer on the Cl-covered Si substrate shows a half-metallic behavior. A Dirac point formed at the K point in the spin-down channel is located exactly at the Fermi level which is crucial for the realization of a quantum spin Hall state. Moreover, the reconstruction process between the Dirac and kagome bands is discussed in detail, providing an interesting platform to study the interplay between massless Dirac fermions and heavy fermions.




    Full Text Available This research used a descriptive qualitative approach. The aims are to describe the implementation Adiwiyata, describe a supporting factor, describes inhibiting factors, and provide a description in overcoming obstacles adiwiyata program at NU SD trawl Road No. 1 Medan. The results showed that the policy environment in the school is going well and integrated into each subject's work utilization of waste paper, palastic and aqua bottles to decorate the atmosphere of the school environment. Besides the establishment of cooperation from local government agencies through the socialization of key activities with the approach of the students and educators in order to gain a good knowledge of the environment, so as to create an atmosphere and environmentally friendly school environment cultured. This proved to won your school's national champion. Some of the barriers are still found among others the limited landfill infrastructure, security officers and public participation around the related concepts of environmentally schools, funding issues, and the support of the community and other agencies are still low. Schools have taken steps to overcome obstacles in the form of strategies to be intensified cooperation with various parties, governments and local communities.

  1. The Structure of the Heavy Calcium Isotopes and the Effective Interaction in the sd-fp Shell

    Dorvaux, O; Nowacki, F; Courtin, S; Marechal, F; Siiskonen, T M; Perrot, F; Pietri, S B


    Nuclei with 40 $<$ A $<$ 56, near the stability line, are very well described in the frame of the shell model. However, when the number of neutrons increases, the situation becomes more complex which explains why the interaction can be found very dissimilar within different calculations. Heavy Ca isotopes, because of the simplicity of their wave-functions, correspond to the optimal choice to fix unambiguously the interaction in this mass region.\\\\ It is proposed to measure the $\\beta$-decay of $^{51, 52, 53}$K with the help of an utmost performing neutron (TONNERRE array) and $\\gamma$- (Miniball clusters) detection, allowing efficient coincidence measurements. This will allow the lowest lying Gamow-Teller states to be located in $^{51, 52, 53}$Ca, and the still unknown properties of natural parity states to be investigated. The awaited results should allow to settle the n-n interaction in the fp shell and the Gnp matrix accross the sd and fp shells, one step farther from stability, by comparison with fu...

  2. The temporal spectrum of the sdB pulsating star HS 2201+2610 at 2 ms resolution

    Silvotti, R.; Janulis, R.; Schuh, S. L.; Charpinet, S.; Oswalt, T.; Silvestri, N.; Gonzalez Perez, J. M.; Kalytis, R.; Meištas, E.; Ališauskas, D.; Marinoni, S.; Jiang, X. J.; Reed, M. D.; Riddle, R. L.; Bernabei, S.; Heber, U.; Bärnbantner, O.; Cordes, O.; Dreizler, S.; Goehler, E.; Østensen, R.; Bochanski, J.; Carlson, G.


    In this article we present the results of more than 180 hours of time-series photometry on the low gravity (log g=5.4, Teff=29 300 K, log He/H=-3.0 by number) sdB pulsating star HS 2201+2610, obtained between September 2000 and August 2001. The temporal spectrum is resolved and shows 5 close frequencies: three main signals at 2860.94, 2824.10 and 2880.69 mu Hz, with amplitudes of about 1%, 0.5% and 0.1% respectively, are detected from single run observations; two further peaks with very low amplitude (Max-Plank-Institute für Astronomie Heidelberg jointly with the Spanish National Commission for Astronomy), SARA 0.9 m (Southeastern Association for Research in Astronomy, at Kitt Peak, Arizona), Tenerife 0.8 m (Instituto de Astrofisica de Canarias), NOT 2.6 m (operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias), Beijing 0.85 m (Beijing Astronomical Observatory), Fick 0.6 m (Iowa State University), Wendelstein 0.8 m (University of Munich).

  3. Simultaneous time-series spectroscopy and multi-band photometry of the sdBV PG 1605+072

    Falter, S; Dreizler, S; Schuh, S L; Cordes, O; Edelmann, H


    We present time-series spectroscopy and multi-band photometry of the sdBV PG 1605+072 carried out simultaneously at the Calar Alto 2.2m and 3.5m telescopes. The periodogram analysis of the radial velocity curves reveals three frequencies at 2.078, 2.756, and 1.985 mHz for Hbeta and at 2.076, 2.753, and 1.978 mHz for Hgamma. The corresponding radial velocity amplitudes are 12.7, 8.0, and 7.9 km/s for Hbeta and 14.3, 6.5, and 7.2 km/s for Hgamma. Furthermore, we found five frequencies that are present in all wavelength bands of the BUSCA photometer. The frequencies detected in the radial velocity curves are recovered by the photometric measurements. Moreover, additional frequencies were present in the periodograms which could not be identified in all four bands simultaneously. The comparison of the amplitudes presented here with previous results from radial velocity and photometric observations of PG 1605+072 shows a significant change or even switch in the power of the modes within short time scales, i. e. abo...


    王全保; 刘运涌; 范新蕾; 田茜; 李伟


    目的:探讨氟代柠檬酸(F C )对脑星形胶质细胞的影响,分析星形胶质细胞是否参与突触蛋白的表达和tau蛋白磷酸化的调控,以期分析阿尔茨海默病的可能发病机制。方法在SD大鼠侧脑室注射1nmol氟代柠檬酸,造成星形胶质细胞三羧酸循环可逆性抑制。采用免疫荧光标记技术;原代海马神经元及星形胶质细胞的培养;western blot检测记忆相关蛋白的水平,如AMPA受体GluR1/2、突触后密度蛋白93/95、A rc、磷酸化的cA M P反应元件相关结合蛋白以及老年痴呆症相关的多个磷酸化位点tau蛋白磷酸化的水平。结果经FC处理可以降低SD大鼠海马神经元记忆相关蛋白水平;通过激活GSK3β或者灭火PP2A活性提高tau蛋白磷酸化的水平。结论 FC对脑星形胶质细胞的功能变化有影响,星形胶质细胞可能参与突触蛋白的表达和tau蛋白磷酸化的调控。%Objective To explore the effect of fluorocitrate (FC) on brain astrocytes and to decide wheth‐er astrocytes are involved in synaptic protein expressions and tau protein phosphorylation regulation in or‐der to find the potential pathogenesis of Alzheimer's disease .Methods 1 nmol fluorocitrate was injected into ventricle of SD rats in order to cause reversible inhibition of Krebs cycle in astrocyte .Immunofluorescence labeling technique was performed and primary hippocampal neurons and astrocytes were cultured .Western blot was carried out in order to detect memory‐related protein levels ,such as the AMPA receptor GluR1/2 ,postsynaptic density protein 93/95 ,Arc ,phosphorylated cAM P response element binding protein and dementia associated plurality of phosphorylation sites of tau protein phosphorylation levels . Results FC treatment reduced the memory associated protein levels in SD rat hippocampal neurons ,and the phospho‐rylation levels of tau protein can be promoted through activating GSK 3βor inhibiting the

  5. Study of SD-UTN Technology and Application in China Unicom Local Unified Transport Networks%中国联通SD-UTN网络技术与应用研究

    曹畅; 胡锦航; 庞冉; 黄永亮; 唐雄燕


    中国联通本地综合承载传送网(UTN)很好地适应了3G/4G时代移动回传业务的承载需求。结合UTN网络长期存在、逐步演进的定位和4G/5G时代多业务承载的需要,研究了将SDN技术引入UTN网络,逐步形成面向业务和用户感知的下一代SD-UTN网络的背景、意义、关键技术和主要应用场景,以及网络演进过程中的重点与难点。通过分析论证,可以发现将SDN技术与UTN设备、网管、OSS等系统结合意义重大,可以实现业务的灵活配置和快速调整,应对未来移动互联网、物联网和专线服务快速发展的需要。%The local unified transport network(UTN)fits China Unicom’s requirement of 3G/4G mobile backhaul. According to UTN’s current condition,and future evolution,it first analyzes the development status of China Unicom’s local unified transport net-works. Then the network problems and relevant SDN solutions are discussed. Final y,the introduction and convergence tech-nology of SDN and practical networks are given and explained. Based on the analysis,the SDN technology has significative in-fluence on UTN,and the capability of providing agile service meets the carrier requirement of future mobile Internet,Internet of things and VPN business wel .

  6. Influence of insufficient blood specimens volume on the detection results of coagulation tests in SD rats%SD 大鼠标本血量不足对凝血四项检测结果的影响

    翟青新; 黄爱军; 钱丽萍


    目的:探讨大鼠的最佳抗凝比,分析标本血量不足对凝血四项检测结果的影响。方法60只大鼠分成2组,按真空采血法采集空腹12 h腹主动脉血液。第一组20只,用于全血细胞测定。全自动血液细胞计数仪检测红细胞压积(hematocrit,HCT),血小板计数(platelet,PLT)。第二组40只,每只鼠采2管血,按抗凝比[枸橼酸钠抗凝剂与全血的比例(V∶V)]分成1∶9(对照组)及1∶5(实验组),1∶8(实验组)及1∶7(实验组),离心获乏血小板血浆。全自动血凝分析仪检测凝血四项:凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplatin time,APTT)、凝血酶时间(thrombin time,TT)、纤维蛋白原(Fibrinogen,FIB)。结果 SD大鼠HCT(%)为41.7±2.9,PLT(×109/L)为1114±173。随着抗凝比的增大,PT、APTT、TT延长,FIB减小。与对照组相比:1∶8实验组,差异无统计学意义。1∶7实验组,除TT差异有统计学意义外,另3项指标差异无统计学意义。1∶5实验组,差异有统计学意义。结论凝血四项的结果受抗凝比的影响。1∶9是大鼠最佳抗凝比,1∶8尚可。大鼠有其独特的生理特性。为大鼠的相关研究提供了基础的科学数据和基本的理论依据。%Objective To explore the best anticoagulant ratio in SD rats .To analyse the influence of insufficient blood specimens volume on coagulation tests .Methods 60 rats were divided into 2 groups.According to the method of vacuum blood, collect abdominal aortic blood after fasting 12 hours.The first group 20 rats were used only for routine blood test.Fully automatic hematology analyzer detected hematocrit and platelet .The second group 40 rats were used for coagulation test .Every rat was collected 2 blood specimens with different anticoagulant ratio [ the proportion of sodium citrate anticoagulation and the

  7. Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208

    Abolfazl Akbari


    Full Text Available Objective(s:Transforming growth factor-β(TGF-β is involved in colorectal cancer (CRC. The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 μM concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c. Data were analyzed using the 2-∆∆CT method through student’s t-test via the GraphPad Prism software. Results: Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006 or tumors orthotopically implanted in nude mice (P=0.018. Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. Conclusion: Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-β inhibitors may be owing to their ability to regulate miRNAs expression.

  8. Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208).

    Akbari, Abolfazl; Ghahremani, Mohammad Hossein; Mobini, Gholam Reza; Abastabar, Mahdi; Akhtari, Javad; Bolhassani, Manzar; Heidari, Mansour


    Transforming growth factor-β (TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 μM concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b) and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c). Data were analyzed using the 2-∆∆CT method through student's t-test via the GraphPad Prism software. Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006) or tumors orthotopically implanted in nude mice (P=0.018). Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-β inhibitors) may be owing to their ability to regulate miRNAs expression.

  9. Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats.

    Navarro-Alarcon, Miguel; Ruiz-Ojeda, Francisco J; Blanca-Herrera, Rosa M; Kaki, Abdullah; Adem, Abdu; Agil, Ahmad


    The use of melatonin, a neurohormone present in plants, represents an exciting approach for the maintenance of optimum health conditions. Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each subdivided into three groups: control (C) (n = 10), vehicle-treated (V') (n = 10) and melatonin-treated (M) (10 mg kg(-1) per day; n = 10) groups for a 6 week period. After treatment, plasma mineral concentrations were measured by flame (Mg) and electrothermal (Cr and V) atomic absorption spectrometry. No significant differences were found between the C and V' groups (p > 0.05). Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. Plasma Mg levels in ZDF rats were not affected by melatonin treatment (p > 0.05). Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats.

  10. Theoretical simulation of CO2 capture by an \\text{A}{{\\text{l}}_{11}}\\text{Mg}_{3}^{-} cluster

    Jiang, Yuanyuan; Xie, Xuefang; Hamid, Ilyar; Chen, Chu; Duan, Haiming


    In order to have an impact on carbon emissions, new stable materials for carbon capture should be able to adsorb CO2 from a mixture of other gases efficiently. Based on density functional theory calculations, we showed that the \\text{A}{{\\text{l}}11}\\text{Mg}3- cluster has an excellent capture capacity of CO2 and high CO2 selectivity under ambient conditions. \\text{A}{{\\text{l}}11}\\text{Mg}3- has an O2-resist property because this cluster is similar to \\text{Al}13- which contains 40 electrons with a larger energy gap. The \\text{A}{{\\text{l}}11}\\text{Mg}3- cluster prefers to adsorb CO2 compared with CH4, H2 and N2, and the CO2 molecule can be chemically adsorbed on the cluster by overcoming a lower barrier, which originates from the introduction of the Mg atom. When seven CO2 molecules are chemically adsorbed on the cluster, the capture capacity of CO2 can reach up to 18.99 mol kg-1 this means that the \\text{A}{{\\text{l}}11}\\text{Mg}3- cluster can be viewed as a potential candidate material for CO2 capture.

  11. UHV and Ambient Pressure XPS: Potentials for Mg, MgO, and Mg(OH)2 Surface Analysis

    Head, Ashley R.; Schnadt, Joachim


    The surface sensitivity of x-ray photoelectron spectroscopy (XPS) has positioned the technique as a routine analysis tool for chemical and electronic structure information. Samples ranging from ideal model systems to industrial materials can be analyzed. Instrumentational developments in the past two decades have popularized ambient pressure XPS, with pressures in the tens of mbar now commonplace. Here, we briefly review the technique, including a discussion of developments that allow data collection at higher pressures. We illustrate the information XPS can provide by using examples from the literature, including MgO studies. We hope to illustrate the possibilities of ambient pressure XPS to Mg, MgO, and Mg(OH)2 systems, both in fundamental and applied studies.

  12. Long Term Sorption Diffusion Experiment (LTDE-SD). Performance of main in situ experiment and results from water phase measurements

    Widestrand, Henrik; Byegaard, Johan; Nilsson, Kersti; Hoeglund, Susanne; Gustafsson, Erik (Geosigma AB, Uppsala (Sweden)); Kronberg, Magnus (Swedish Nuclear Fuel and Waste Management Co. (Sweden))


    The LTDE-SD experiment, (Long Term Sorption Diffusion Experiment) aimed at increasing the scientific knowledge of sorption and diffusion under in situ conditions and to provide data for performance and safety assessment calculations. Performance and results of the in situ experiment phase are presented in the report. In total, 21 radionuclide trace elements and one stable trace element were injected, circulated and sampled for approx6.5 months in a closed borehole section. The trace elements represented non-sorbing tracers and sorbing tracers for which the sorption was dominated by a cation exchange mechanism, a surface complexation mechanism, or dependent on an electrochemical reduction in order to reach the tetravalent state (oxidation state IV) considered very strongly sorbing. The borehole section in contact with the tracer labelled groundwater consisted in part of a natural fracture surface and a borehole section in the unaltered matrix rock, devoid of natural fractures. Water samples were regularly extracted and analysed for trace element concentration and a few ion exchange speciation and filtered samplings were also conducted. Independent colloid filtering and chemical speciation calculations were performed in support the evaluation. Sorption was demonstrated for a series of elements present in the experiment. The amounts lost of the different respective tracers from the aqueous phase follow very well the general understanding of the relative sorption strength of the tracers, as inferred from e.g. batch sorption experiments and dynamic in situ tracer experiments. The chemical speciation calculations of the different tracers were in line with the results of the ion exchange speciation performed during the experiment. With the exception of UO{sub 2} 2+ carbonate complexes formed, no strong indications were obtained that aqueous complexation prevents adsorption under the chemical conditions of the experiment. The 20 nm filtered sampling indicated that

  13. Scan direction induced charging dynamics and the application for detection of gate to S/D shorts in logic devices

    Lei, Ming; Tian, Qing; Wu, Kevin; Zhao, Yan


    Gate to source/drain (S/D) short is the most common and detrimental failure mechanism for advanced process technology development in Metal-Oxide-Semiconductor-Field-Effect-Transistor (MOSFET) device manufacturing. Especially for sub-1Xnm nodes, MOSFET device is more vulnerable to gate-S/D shorts due to the aggressive scaling. The detection of this kind of electrical short defect is always challenging for in-line electron beam inspection (EBI), especially new shorting mechanisms on atomic scale due to new material/process flow implementation. The second challenge comes from the characterization of the shorts including identification of the exact shorting location. In this paper, we demonstrate unique scan direction induced charging dynamics (SDCD) phenomenon which stems from the transistor level response from EBI scan at post metal contact chemical-mechanical planarization (CMP) layers. We found that SDCD effect is exceptionally useful for gate-S/D short induced voltage contrast (VC) defect detection, especially for identification of shorting locations. The unique SDCD effect signatures of gate-S/D shorts can be used as fingerprint for ground true shorting defect detection. Correlation with other characterization methods on the same defective location from EBI scan shows consistent results from various shorting mechanism. A practical work flow to implement the application of SDCD effect for in-line EBI monitor of critical gate-S/D short defects is also proposed, together with examples of successful application use cases which mostly focus on static random-access memory (SRAM) array regions. Although the capability of gate-S/D short detection as well as expected device response is limited to passing transistors and pull-down transistors due to the design restriction from standard 6-cell SRAM structure, SDCD effect is proven to be very effective for gate-S/D short induced VC defect detection as well as yield learning for advanced technology development.

  14. Exposure to butyl paraben during gestation and lactation in Hsd:Sprague dawley SD rats via dosed feed

    Georgia K. Roberts


    Full Text Available Butyl paraben (BPB is an antimicrobial used in a variety of consumer products. Due to widespread human exposure and reported estrogenic activity, the National Toxicology Program quantified internal exposure during critical periods of development. Time-mated female Hsd:Sprague Dawley SD rats were administered 0, 1500, 5000 or 15,000 ppm BPB via NIH-07 feed, ad libitum, from gestation day (GD 6 to postnatal day (PND 28. Dam plasma, amniotic fluid and fetuses were collected on GD18 and pup and dam plasma were collected on PNDs 4, 10, 14, 21 and 28 and analyzed for free (unconjugated and total (unconjugated and conjugated BPB using liquid chromatography-tandem mass spectrometry. Free BPB was below the limit of quantitation in fetuses (LOQ 1.91 ng BPB/g fetus and amniotic fluid (LOQ 0.17 ng BPB/mL amniotic fluid at 1500 ppm. Analyte levels in amniotic fluid were less than 1% of maternal plasma, suggesting limited placental transfer. Total BPB in PND4 pup plasma was less than 5% of dam plasma in all exposure groups, suggesting low lactational transfer. However, at nearly all time points and exposure groups, there were higher levels of free BPB in pup versus dam plasma, suggesting limited conjugation in pups. Pup conjugation of BPB was age-dependent, not reaching the percent-conjugation in dams (>99% until PNDs 21 to 28. These data illustrate low placental and lactational transfer of dietary BPB and that poor conjugation in pups during early lactation results in higher exposure to free BPB in pups compared to dams.

  15. Systems dynamics (SD) strategy for Small Modular Reactor (SMR) marketing - Conquest at the MIT Energy Laboratory (Pres. MIT Energy Initiative)

    Woo, T. H. [Yonsei University, Wonju (Korea, Republic of)


    This reactor has the specification as the power is 330 MWt pressurized water reactor (PWR) with integral steam generators and advanced safety features. In the plant design, it is planned for electricity generation of 100 MWe and thermal applications of seawater desalination where the life span is a 60-year operation design and three-year refueling cycle. Regarding of the licensing, the standard design was approved from the Korean regulator in mid-2012 and the Korea Atomic Energy Research Institute (KAERI) has a plan to build a demonstration plant to operate from 2017. According to the previous study of the marketing strategy of the Canadian small reactor, Safe LOW-POwer Kritical Experiment (SLOWPOKE) reactor had been investigated in 1988. Therefore, it is interesting to compare SMART and SLOWPOKE. In this work, it is to find out the strategy of the successful marketing of SMART and suggest continuous marketing prospects. There are specifications and parameters of SMART in Tables 1 and 2. The public acceptance (PA) had been studies as safety-public interpretation, SLOWPOKE safety-experience and process, and economics in the previous paper of the SLOWPOKE, which was about the marketing strategy for the commercial nuclear reactor. The highly cognitive networking based dynamical modeling was discussed where the system is treated by a complex and non-linear way. The linear networking of the interested issue was changed by the SD algorithm where the feedback and multiple connections are added to the original networking theory. The non-linear method has shown the complexity of the marketing strategy, especially for the NPP which is the very expensive and safety focused facility.

  16. Feasibility of utilizing the SD BIOLINE Onchocerciasis IgG4 rapid test in onchocerciasis surveillance in Senegal.

    Dieye, Yakou; Storey, Helen L; Barrett, Kelsey L; Gerth-Guyette, Emily; Di Giorgio, Laura; Golden, Allison; Faulx, Dunia; Kalnoky, Michael; Ndiaye, Marie Khemesse Ngom; Sy, Ngayo; Mané, Malang; Faye, Babacar; Sarr, Mamadou; Dioukhane, Elhadji Mamadou; Peck, Roger B; Guinot, Philippe; de Los Santos, Tala


    As effective onchocerciasis control efforts in Africa transition to elimination efforts, different diagnostic tools are required to support country programs. Senegal, with its long standing, successful control program, is transitioning to using the SD BIOLINE Onchocerciasis IgG4 (Ov16) rapid test over traditional skin snip microscopy. The aim of this study is to demonstrate the feasibility of integrating the Ov16 rapid test into onchocerciasis surveillance activities in Senegal, based on the following attributes of acceptability, usability, and cost. A cross-sectional study was conducted in 13 villages in southeastern Senegal in May 2016. Individuals 5 years and older were invited to participate in a demographic questionnaire, an Ov16 rapid test, a skin snip biopsy, and an acceptability interview. Rapid test technicians were interviewed and a costing analysis was conducted. Of 1,173 participants, 1,169 (99.7%) agreed to the rapid test while 383 (32.7%) agreed to skin snip microscopy. The sero-positivity rate of the rapid test among those tested was 2.6% with zero positives 10 years and younger. None of the 383 skin snips were positive for Ov microfilaria. Community members appreciated that the rapid test was performed quickly, was not painful, and provided reliable results. The total costs for this surveillance activity was $22,272.83, with a cost per test conducted at $3.14 for rapid test, $7.58 for skin snip microscopy, and $13.43 for shared costs. If no participants had refused skin snip microscopy, the total cost per method with shared costs would have been around $16 per person tested. In this area with low onchocerciasis sero-positivity, there was high acceptability and perceived value of the rapid test by community members and technicians. This study provides evidence of the feasibility of implementing the Ov16 rapid test in Senegal and may be informative to other country programs transitioning to Ov16 serologic tools.

  17. Diffusion of Ca and Mg in Calcite

    Cygan, R.T.; Fisler, D.K.


    The self-diffusion of Ca and the tracer diffusion of Mg in calcite have been experimentally measured using isotopic tracers of {sup 25}Mg and {sup 44}Ca. Natural single crystals of calcite were coated with a thermally-sputtered oxide thin film and then annealed in a CO{sub 2} gas at one atmosphere total pressure and temperatures from 550 to 800 C. Diffusion coefficient values were derived from the depth profiles obtained by ion microprobe analysis. The resultant activation energies for Mg tracer diffusion and Ca self-diffusion are respectively: E{sub a}(Mg) = 284 {+-} 74 kJ/mol and E{sub a}(Ca) = 271 {+-} 80 kJ/mol. For the temperature ranges in these experiments, the diffusion of Mg is faster than Ca. The results are generally consistent in magnitude with divalent cation diffusion rates obtained in previous studies and provide a means of interpreting the thermal histories of carbonate minerals, the mechanism of dolomitization, and other diffusion-controlled processes. The results indicate that cation diffusion in calcite is relatively slow and cations are the rate-limiting diffusing species for the deformation of calcite and carbonate rocks. Application of the calcite-dolomite geothermometer to metamorphic assemblages will be constrained by cation diffusion and cooling rates. The direct measurement of Mg tracer diffusion in calcite indicates that dolomitization is unlikely to be accomplished by Mg diffusion in the solid state but by a recrystallization process.

  18. SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway

    Zhao, Ying; Chen, Huan; Shang, Zhuo; Jiao, Binghua; Yuan, Bin; Sun, Weizhang; Wang, Bingui; Miao, Mingyong; Huang, Caiguo


    A compound named SD118-xanthocillin X (1) (C18H12N2O2), isolated from Penicillium commune in a deep-sea sediment sample, has been shown to inhibit the growth of several cancer cell lines in vitro. In the present study, we employed a growth inhibition assay and apoptotic analysis to identify the biological effect and detailed mechanism of SD118-xanthocillin X (1) in human hepatocellular carcinoma (HepG2) cells. SD118-xanthocillin X (1) demonstrated a concentration-dependent inhibitory effect on the growth of HepG2 cells and caused slight cellular apoptosis and significantly induced autophagy. Autophagy was detected as early as 12 h by the conversion of microtubule-associated protein 1 light chain 3 (LC3-I) to LC3-II, following cleavage and lipid addition to LC3-I. The pharmacological autophagy inhibitor 3-methyladenine largely attenuates the growth inhibition and autophagic effect of SD118-xanthocillin X (1) in HepG2 cells. Our data also indicated that the autophagic effect of SD118-xanthocillin X (1) occurs via the down-regulation of the MEK/ERK signaling pathway and the up-regulated class III PI3K/Beclin 1 signaling pathway. PMID:22822377

  19. The orbits of subdwarf B + main-sequence binaries. I: The sdB+G0 system PG 1104+243

    Vos, J; Degroote, P; De Smedt, K; Green, E M; Heber, U; Van Winckel, H; Acke, B; Bloemen, S; De Cat, P; Exter, K; Lampens, P; Lombaert, R; Masseron, T; Menu, J; Neyskens, P; Raskin, G; Smolders, K; Tkachenko, A; Ringat, E; Rauch, T


    The predicted orbital period histogram of an sdB population is bimodal with a peak at short ( 250 days) periods. Observationally, there are many short-period sdB systems known, but only very few long-period sdB binaries are identified. As these predictions are based on poorly understood binary interaction processes, it is of prime importance to confront the predictions to observational data. In this contribution we aim to determine the absolute dimensions of the long-period sdB+MS binary system PG1104+243. High-resolution spectroscopy time-series were obtained with HERMES at the Mercator telescope at La Palma, and analyzed to obtain radial velocities of both components. Photometry from the literature was used to construct the spectral energy distribution (SED) of the binary. Atmosphere models were used to fit this SED and determine the surface gravity and temperature of both components. The gravitational redshift provided an independent confirmation of the surface gravity of the sdB component. An orbital peri...

  20. Evaluation of SD BIOLINE Syphilis 3.0 for Rapid Diagnosis of Syphilis: Report from a Regional Sexually Transmitted Infection Reference Laboratory in North India.

    Mehra, Bhanu; Bhattar, Sonali; Saxena, Shikhar; Rawat, Deepti; Bhalla, Preena


    Serology is considered the mainstay of syphilis diagnosis. The limitations of the traditional serological methods and the advent and availability of novel immunochromatographic assays have led to the widespread application of rapid point-of-care procedures as screening tools for syphilis. However, these tests have not been extensively evaluated. This study was designed to evaluate the performance of a rapid syphilis diagnostic test known as SD BIOLINE Syphilis 3.0 (SD Biostandard Diagnostics Private Limited, Gurgaon, Haryana, India). A panel comprising of 50 venereal disease research laboratory reactive and 50 nonreactive sera was tested using SD BIOLINE Syphilis 3.0. The performance of the test was evaluated using IMMUTREP Treponema pallidum hemagglutination assay (TPHA) (OMEGA Diagnostics Limited, Scotland, United Kingdom) as the reference standard and sensitivity, specificity, and negative and positive predictive values were calculated. The sensitivity, specificity, and positive and negative predictive values of SD BIOLINE Syphilis 3.0 were 92.86% (confidence interval of 95%: 80.52-98.50%), 98.28% (90.76-99.96%), 97.50% (86.84-99.94%), and 95.00% (86.08-98.96%), respectively, compared to TPHA as the gold standard. Keeping in view the high sensitivity and specificity of SD BIOLINE Syphilis 3.0, we conclude that the test can be used as a tool for rapid on-site diagnosis of syphilis and as an alternative to TPHA for detection of antibodies to Treponema pallidum.

  1. T-Duality of Green-Schwarz Superstrings on AdS(d) x S(d) x M(10-2d)

    Abbott, Michael C; Penati, Silvia; Pittelli, Antonio; Sorokin, Dmitri; Sundin, Per; Tarrant, Justine; Wolf, Martin; Wulff, Linus


    We verify the self-duality of Green-Schwarz supercoset sigma models on AdS$_d \\times S^d $ backgrounds (d=2,3,5) under combined bosonic and fermionic T-dualities without gauge fixing kappa symmetry. We also prove this property for superstrings on AdS$_d \\times S^d \\times S^d$ (d=2,3) described by supercoset sigma models with the isometries governed by the exceptional Lie supergroups $D(2,1;\\alpha)$ (d=2) and $D(2,1;\\alpha)\\times D(2,1;\\alpha)$ (d=3), which requires an additional T-dualisation along one of the spheres. Then, by taking into account the contribution of non-supercoset fermionic modes (up to the second order), we provide evidence for the T-self-duality of the complete type IIA and IIB Green-Schwarz superstring theory on AdS$_d\\times S^d \\times T^{10-2d}$ (d=2,3) backgrounds with Ramond-Ramond fluxes. Finally, applying the Buscher-like rules to T-dualising supergravity fields, we prove the T-self-duality of the whole class of the AdS$_d\\times S^d \\times M^{10-2d}$ superbackgrounds with Ramond-Ramon...

  2. Modeling the System Parameters of 2M1533+3759: A New Longer-Period Low-Mass Eclipsing sdB+dM Binary

    For, B -Q; Fontaine, G; Drechsel, H; Shaw, J S; Dittmann, J A; Fay, A G; Francoeur, M; Laird, J; Moriyama, E; Morris, M; Rodríguez-López, C; Sierchio, J M; Story, S M; Strom, A; Wang, C; Adams, S M; Bolin, D E; Eskew, M; Chayer, P


    We present new photometric and spectroscopic observations for 2M 1533+3759 (= NSVS 07826147). It has an orbital period of 0.16177042 day, significantly longer than the 2.3--3.0 hour periods of the other known eclipsing sdB+dM systems. Spectroscopic analysis of the hot primary yields Teff = 29230 +/- 125 K, log g = 5.58 +/- 0.03 and log N(He)/N(H) = -2.37 +/- 0.05. The sdB velocity amplitude is K1 = 71.1 +/- 1.0 km/s. The only detectable light contribution from the secondary is due to the surprisingly strong reflection effect. Light curve modeling produced several solutions corresponding to different values of the system mass ratio, q(M2/M1), but only one is consistent with a core helium burning star, q=0.301. The orbital inclination is 86.6 degree. The sdB primary mass is M1 = 0.376 +/- 0.055 Msun and its radius is R1 = 0.166 +/- 0.007 Rsun. 2M1533+3759 joins PG0911+456 (and possibly also HS2333+3927) in having an unusually low mass for an sdB star. SdB stars with masses significantly lower than the canonical...

  3. Quantum Phase Transition of Nuclear Shape and Potential Energy Surface in Microscopic sdIBM-(F)max Approach%核形状量子相变与微观sdIBM-(F)max的势能曲面

    汪红; 童红; 石筑一; 张春梅


    Using the two kinds of excitation spectra of approach for the satisfactorily reproducing nuclear complex spectrum, this treatment revealed a new understanding of phase transitions as the basis state structure of original excitation mode and its advantages in energy were relieved by de-excitation, the basis state of high-ordered structure release energy, at the same time the basis state structure of the low-energy excitation mode was restructured, the transition between new basis state and old one was achieved. This kind of change is one that is completed by the adjustment of the nuclear coupling strength, and a dynamic microscopic fundament of the rotational driven quantum phase transition, which is a suave microscopically. This new understanding is obtained from theory of potential energy surfaces of the Bohr collective model. Thus,the results of micro-sdIBM-Fmax are supported by the Bohr collective model.%通过用两种激发模式对原子核复杂能谱的良好再现,揭示出对激发模式相变的一种新理解:由于退激发解除了原有激发模式基准态结构及其在能量上的优势,高有序基准态释放结构能,同时引发低能激发模式基准态结构的重构,实现了新旧激发模式基准态的过渡.这种以改变价核子间藕合强度方式实现的基准态过渡,是转动驱动量子相变的动力学基础,从微观上看比较温和.本工作结果得到Bohr集体模型势能曲面理论的支持,两者相得益彰.

  4. Treatment of patients with essential hypertension: amlodipine 5 mg/benazepril 20 mg compared with amlodipine 5 mg, benazepril 20 mg, and placebo.

    Kuschnir, E; Acuña, E; Sevilla, D; Vasquez, J; Bendersky, M; Resk, J; Glazer, R


    This multicenter, double-masked, randomized, parallel-group study compared the efficacy, tolerability, and safety of amlodipine 5 mg/benazepril 20 mg, amlodipine 5 mg, benazepril 20 mg, and placebo in patients with essential hypertension. After a placebo run-in period, 308 patients (all white) were randomized to treatment groups and took medication once daily for 8 weeks. Blood pressure was measured after 4 and 8 weeks of treatment in the 23- to 26-hour period after dosing. Patients wore a noninvasive blood pressure monitor for 24 hours before randomization and before the final visit. Investigators recorded adverse experiences at randomization and at study weeks 4 and 8, and obtained specimens for laboratory testing at randomization and at study week 8. Three hundred seven patients were evaluated for efficacy, and 308 for tolerability and safety. At end point (the last postrandomization measurement for each patient), the reduction in mean sitting diastolic blood pressure with the amlodipine 5 mg/benazepril 20 mg treatment was statistically significantly greater than with any comparative therapy. The results of 24-hour monitoring showed that the amlodipine/benazepril treatment, unlike monotherapy, maintained the hourly mean diastolic blood pressure at amlodipine 5 mg/benazepril 20 mg versus 67.5%, 53.3%, and 15.8% with amlodipine, benazepril, and placebo, respectively. This difference between the amlodipine/benazepril treatment group and each comparative single-agent treatment group was statistically significant. Drug-related adverse events occurred in 15.6% of patients in the amlodipine/benazepril group and in 24.7%, 6.5%, and 11.7% of patients in the amlodipine, benazepril, and placebo groups, respectively. Edema occurred less often in the amlodipine/benazepril group than in the amlodipine group. Overall, once-daily therapy with amlodipine 5 mg/benazepril 20 mg provided an antihypertensive effect that was statistically and clinically superior to amlodipine 5 mg

  5. Solvation of Mg in Helium-4: Are there Meta-stable Mg Dimers ?

    Krotscheck, Eckhard


    Experiments on the formation of magnesium complexes in $^4$He nanodroplets were interpreted as the observation of the formation of weakly bound magnesium complexes. We present results for single Mg and Mg dimer solvation using the hypernetted chain / Euler-Lagrange method as well as path integral Monte Carlo simulations. We find that the phonon-mediated, indirect Mg-Mg interaction adds an oscillatory component to the direct Mg-Mg interaction. We undertake a step-by-step examination of the ingredients of the calculation of the phonon-induced interaction, comparing the results of semi-analytic HNC-EL calculations for bulk and single impurity results with experiments as well as Monte Carlo data. We do not find evidence for a sufficiently strong secondary minimum in the effective Mg-Mg interaction to support a metastable state.

  6. The role of MgO content in ex situ MgB2 wires

    Kovac, P.; Hugek, I.; Meligek, T.;


    An experimental study of the effect of MgO content in the MgB2 powder used for ex situ made composite wires was carried out. Two single-core MgB2/Fe/Cu wires were made using commercial MgB2 powders from Alfa Aesar containing different fraction of MgO. Critical temperature and critical currents...... of as-deformed and heat-treated wires were measured. The differences between the wires are discussed and correlated with the MgO content. It was found that by increasing the amount of MgO, the inter-grain connectivity worsens, but well distributed and low size MgO particles improve flux pinning....

  7. Teratogenicity of Chitosan in SD Rats%壳聚糖对大鼠的致畸胎试验

    杨海峰; 万荣峰; 张玲玲; 覃少华; 江善祥


    背景与目的:通过在胚胎器官形成期连续给药,观察壳聚糖对大鼠的胚胎毒性和致畸毒性.材料与方法:将90只妊娠SD大鼠按时间先后随机分为5组,即阴性对照组、壳聚糖50、250、1000 mg/k剂量组和阳性对照组,每组18只.在大鼠胚胎器官形成期(妊娠的第6~15 d),壳聚糖各剂量组和阴性对照组连续给受试物10 d,每日经口灌胃分别给予壳聚糖和生理盐水,阳性对照组在孕期第11~13 d每天腹腔注射环磷酰胺(cyclophosphamide,CP)7 mg/kg,在妊娠的第20 d处死大鼠进行胎鼠检查.结果:壳聚糖对孕鼠的健康状况、行为、增重和生殖机能无明显影响;对胎鼠的生长发育无明显影响;对胎鼠的外观、骨骼和内脏无致畸作用.结论:在≤1000 mg/kg剂量下,壳聚糖对大鼠无胚胎毒性和致畸毒性.

  8. Aging Behavior of Mg-Y-Zr and Mg-Nd-Zr Cast Alloys


    Aging behavior of Mg-3.6Y-0.5Zr and Mg-2.7Nd-0.5Zr alloys was investigated by microhardness measurement and transmission electron microscopy. In the case of Mg-Y-Zr alloy, the presence of β″ phase, a major strengthener, having base centered orthorhombic structure with its lattice constants of aβ″=0.64 nm, bβ″=2.22 nm,and cβ″=0.52 nm was identified. In the case of Mg-Nd-Zr alloy aged at 250℃, the presence ofβ″ and β′phases was identified. The crystal structure ofβ″ phase was found to be DO19 and its orientation relationships with Mg matrix were [0001]β″//[0001]Mg and [01-10]β″//[0110]Mg. The β′ phase had face centered cubicstructure and its orientation relationships with Mg matrix were [011]β′//[0001]Mg and [-11-1]β′//[-2110]Mg.The Mg-2.7Nd-0.5Zr alloy showed higher hardness compared with Mg-3.6Y-0.5Zr alloy.

  9. In vitro and in vivo comparison of binary Mg alloys and pure Mg.

    Myrissa, Anastasia; Agha, Nezha Ahmad; Lu, Yiyi; Martinelli, Elisabeth; Eichler, Johannes; Szakács, Gábor; Kleinhans, Claudia; Willumeit-Römer, Regine; Schäfer, Ute; Weinberg, Annelie-Martina


    Biodegradable materials are under investigation due to their promising properties for biomedical applications as implant material. In the present study, two binary magnesium (Mg) alloys (Mg2Ag and Mg10Gd) and pure Mg (99.99%) were used in order to compare the degradation performance of the materials in in vitro to in vivo conditions. In vitro analysis of cell distribution and viability was performed on discs of pure Mg, Mg2Ag and Mg10Gd. The results verified viable pre-osteoblast cells on all three alloys and no obvious toxic effect within the first two weeks. The degradation rates in in vitro and in vivo conditions (Sprague-Dawley® rats) showed that the degradation rates differ especially in the 1st week of the experiments. While in vitro Mg2Ag displayed the fastest degradation rate, in vivo, Mg10Gd revealed the highest degradation rate. After four weeks of in vitro immersion tests, the degradation rate of Mg2Ag was significantly reduced and approached the values of pure Mg and Mg10Gd. Interestingly, after 4 weeks the estimated in vitro degradation rates approximate in vivo values. Our systematic experiment indicates that a correlation between in vitro and in vivo observations still has some limitations that have to be considered in order to perform representative in vitro experiments that display the in vivo situation.

  10. The Mg impurity in nitride alloys

    Zvanut, M. E.; Willoughby, W. R.; Sunay, U. R. [Department of Physics, University of Alabama at Birmingham, Birmingham AL (United States); Koleske, D. D.; Allerman, A. A. [Sandia National Laboratory, Albuquerque NM (United States); Wang, Ke; Araki, Tsutomu [Department of Photonics, Ritsumeikan University, Kusatsu, Shiga (Japan); Nanishi, Yasushi [Department of Photonics, Ritsumeikan University, Kusatsu, Shiga, Japan and WCU Program, Department of Materials Science and Engineering, Seoul National University, Seoul (Korea, Republic of)


    Although several magnetic resonance studies address the Mg acceptor in GaN, there are few reports on Mg doping in the alloys, where hole production depends strongly on the Al or In content. Our electron paramagnetic resonance (EPR) measurements of the p-type alloys suggest that the Mg impurity retains the axial symmetry, characteristic of a p-type dopant in both alloys; however, In and Al produce additional, different characteristics of the acceptor. In InGaN, the behavior is consistent with a lowering of the acceptor level and increasing hole density as In concentration increases. For AlGaN, the amount of neutral Mg decreases with increasing Al content, which is attributed to different kinetics of hydrogen diffusion thought to occur in samples with higher Al mole fraction.

  11. Thermodynamic optimization of Mg-Nd system

    MENG Fan-gui; LIU Hua-shan; LIU Li-bin; JIN Zhan-peng


    Based on the reported experimental data, the phase diagram of Mg-Nd binary system was optimized using the CALPHAD approach. Gibbs energies of the disordered BCC_A2 and ordered BCC_B2 phases were modeled with a single expression based on a 2-sublattice model. Liquid and terminal solutions, such as dHCP and HCP, were modeled as substitutional solutions. Intermediate phases Mg2Nd, Mg3Nd and Mg41Nd5 were treated as stoichiometric compounds. The optimization was carried out in the Thermo-Calc package. A set of thermodynamic parameters is obtained. Calculated phase diagram, enthalpies of formation and Gibbs energies of formation are in reasonable agreement with the experimental data.

  12. Usefulness of measurement of circulation time using MgSO{sub 4} : correlation with time-density curve using electron beam computed tomography

    Kim, Byung Ki; Lee, Hui Joong; Lee, Jong Min; Kim, Yong Joo; Kang, Duck Sik [Kyungpook National Univ., Kyungpook National Univ. Hospital, College of Medicine, Taegu (Korea, Republic of)


    To determine the usefulness of MgSO{sub 4} for measuring the systemic circulation time. Systemic circulation time, defined as elapsed time from the injection of MgSO{sub 4} solution to the point of pharyngeal burning sensation, was measured in 63 volunteers. MgSO{sub 4} was injected into a superficial vein of an upper extremity. Using dynamic electron beam computed tomography at the level of the abdominal aorta and celiac axis, a time-intensity curve was plotted, and for these two locations, maximal enhancement time was compared. For 60 of the 63 subjects, both systemic circulation time and maximal enhancement time were determined. Average systemic circulation time was 17.4 (SD:3.6) secs. and average maximal enhancement times at the level of the abdominal aorta and celiac axis were 17.5 (SD:3.0) secs. and 18.5 (SD:3.2) secs., respectively. Correlation coefficients between systemic circulation time and maximal enhancement time for the abdominal aorta and celiac axis were 0.73 (p<0.01) and 0.73 (p<0.05) respectively. The systemic circulation time demonstrated by MgSO{sub 4} injection and maximal enhancement time for the abdominal aorta showed significant correlation. Thus, to determine the appropriate scanning time in contrast-enhanced radiological studies, MgSO{sub 4} can be used instead of a test bolus study.

  13. A New Look at 29Al and 27Mg from the 18O + 14C Reaction

    Tabor, Samuel; Dungan, Rutger; Volya, Alexander; Tripathi, Vandana; Abromeit, Brittany; Caussyn, David; Kravvaris, Konstantinos; Lubna, Rebeka; Tai, Pei-Luan


    It was possible to compare moderately high-spin states in a nearby pair of odd proton and odd neutron s-d shell nuclei by observing proton-gamma-gamma or alpha-gamma-gamma coincidences, respectively, following the fusion of long-lived radioactive 14C with neutron-rich 18O at a beam energy of 40 MeV using the FSU gamma detector array with digital data acquisition. Eight new states were seen in 29Al, all of which decay directly or indirectly to the 9/2 + level, the highest previously known spin in 29Al. Some of the new states form a very likely yrast M1 decay sequence from (15/2 +) down to the 5/2 + ground state. The new states are relatively well described by pure s-d shell model calculations using the USDA interaction. By contrast the 4 new states found in 27Mg are divided between positive and negative parities reaching up to (13/2 +) and (11/2-). Radiative decays of neutron unbound states in 27Mg will be discussed. Supported in part by NSF Grant No. 1401574.

  14. MgH{sub 2} as dopant for improved activation of commercial Mg ingot

    Jain, P., E-mail: [Hydrogen Research Institute, Université du Québec à Trois-Rivières, 3351 des Forges, Trois-Rivières, Québec G9A 5H7 (Canada); Lang, J. [Hydrogen Research Institute, Université du Québec à Trois-Rivières, 3351 des Forges, Trois-Rivières, Québec G9A 5H7 (Canada); Skryabina, N.Y. [Department of Physics, Perm State University, 15, Bukireva, 614990 Perm (Russian Federation); Fruchart, D. [Institut Néel, BP 166, 38042 Grenoble Cedex 9 (France); Santos, S.F [CECS, Federal University of ABC, Rua Santa Adélia 166, Santo André, SP 09210-170 (Brazil); Binder, K.; Klassen, T. [Institute of Materials Technology, Helmut-Schmidt-University, University of the Federal Armed Forces, Holstenhofweg 85, 22043 Hamburg (Germany); Huot, J., E-mail: [Hydrogen Research Institute, Université du Québec à Trois-Rivières, 3351 des Forges, Trois-Rivières, Québec G9A 5H7 (Canada)


    Highlights: •We propose a simple method to reduce production cost of light weight materials for hydrogen storage applications. •Cheaper Mg ingot rather than expensive MgH{sub 2} is used as starting material. •Effect of MgH{sub 2} as catalytic powder for improved activation behavior of Mg is demonstrated. -- Abstract: In this paper, we propose a method to decrease the activation time (first hydrogenation) of commercial Mg. This new alternative processing route uses a combination of cold rolling and short time ball milling to obtain full hydrogen capacity quickly in the first hydrogenation. As ball milling of ductile materials leads to particle agglomeration, brittle Mg plates produced by repetitive cold rolling were used as starting material. These rolled plates were then ball milled for 30 min with and without the addition of 5 wt% Mg or MgH{sub 2} powders. All the synthesized samples were investigated for hydrogen storage, absorption–desorption behavior and microstructure using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and pressure-composition temperature (PCT) methods. Results showed slow activation behavior for cold rolled Mg plates, which was slightly improved after milling. Further improvement was obtained by adding 5 wt% of Mg powder during ball milling. In contrast, when the plates were ball milled with 5 wt% of MgH{sub 2} powder a drastic improvement in activation behavior was observed with hydrogen capacity reaching up to 6.2 wt% in comparison to 2.74 wt% for undoped and 3.57 wt% for Mg doped samples. These results reveal that ball milling with ductile Mg powder deforms only the surface of Mg plates while brittle MgH{sub 2} powders causes fracturing and cracks, increasing the surface area and generating heterogeneous nucleation sites within the bulk material.

  15. Control of grain protein contents through SEMIDWARF1 mutant alleles: sd1 increases the grain protein content in Dee-geo-woo-gen but not in Reimei.

    Terao, Tomio; Hirose, Tatsuro


    A new possibility for genetic control of the protein content of rice grains was suggested by the allele differences of the SEMIDWARF1 (SD1) mutation. Two quantitative trait loci-qPROT1 and qPROT12-were found on chromosomes 1 and 12, respectively, using backcrossed inbred lines of Sasanishiki/Habataki//Sasanishiki///Sasanishiki. One of them, qPROT1, increased almost all grain proteins instead of only certain proteins in the recessive Habataki allele. Fine mapping of qPROT1 revealed that two gene candidates-Os01g0883800 and Os01g0883900-were included in this region. Os01g0883800 encoded Gibberellin 20 oxidase 2 as well as SD1, the dwarf gene used in the so-called 'Green Revolution'. Mutant analyses as well as sequencing analysis using the semi-dwarf mutant cultivars Dee-geo-woo-gen and Calrose 76 revealed that the sd1 mutant showed significantly higher grain protein contents than their corresponding wild-type cultivars, strongly suggesting that the high protein contents were caused by sd1 mutation. However, the sd1 mutant Reimei did not have high grain protein contents. It is possible to control the grain protein content and column length separately by selecting for sd1 alleles. From this finding, the genetic control of grain protein content, as well as the column length of rice cultivars, might be possible. This ability might be useful to improve rice nutrition, particularly in areas where the introduction of semi-dwarf cultivars is not advanced.

  16. How to predict return to work after lumbar discectomy: answers from the NeuroPoint-SD registry.

    Than, Khoi D; Curran, Jill N; Resnick, Daniel K; Shaffrey, Christopher I; Ghogawala, Zoher; Mummaneni, Praveen V


    OBJECTIVE To date, the factors that predict whether a patient returns to work after lumbar discectomy are poorly understood. Information on postoperative work status is important in analyzing the cost-effectiveness of the procedure. METHODS An observational prospective cohort study was completed at 13 academic and community sites (NeuroPoint-Spinal Disorders [NeuroPoint-SD] registry). Patients undergoing single-level lumbar discectomy were included. Variables assessed included age, sex, body mass index (BMI), SF-36 physical function score, Oswestry Disability Index (ODI) score, presence of diabetes, smoking status, systemic illness, workers' compensation status, and preoperative work status. The primary outcome was working status within 3 months after surgery. Stepwise logistic regression analysis was performed to determine which factors were predictive of return to work at 3 months following discectomy. RESULTS There were 127 patients (of 148 total) with data collected 3 months postoperatively. The patients' average age at the time of surgery was 46 ± 1 years, and 66.9% of patients were working 3 months postoperatively. Statistical analyses demonstrated that the patients more likely to return to work were those of younger age (44.5 years vs 50.5 years, p = 0.008), males (55.3% vs 28.6%, p = 0.005), those with higher preoperative SF-36 physical function scores (44.0 vs 30.3, p = 0.002), those with lower preoperative ODI scores (43.8 vs 52.6, p = 0.01), nonsmokers (83.5% vs 66.7%, p = 0.03), and those who were working preoperatively (91.8% vs 26.2%, p working preoperatively (105 patients), only age was a statistically significant predictor of postoperative return to work (44.1 years vs 51.1 years, p = 0.049). CONCLUSIONS In this cohort of lumbar discectomy patients, preoperative working status was the strongest predictor of postoperative working status 3 months after surgery. Younger age was also a predictor. Factors not influencing return to work in the logistic

  17. Hubungan Tingkat Pengetahuan Ibu tentang Gizi dengan Kejadian Obesitas Anak di SD Islam Al-Azhar 32 Padang

    Merisya .


    Full Text Available AbstrakObesitas adalah kelainan yang ditandai oleh penimbunan berlebihan jaringan lemak dalam tubuh. Salah satu kelompok usia yang berisiko mengalami obesitas adalah kelompok usia 6-12 tahun. Pengetahuan gizi ibu berhubungan dengan kejadian obesitas pada anak.Hal tersebut mempengaruhi pemilihan nutrisi yang dikonsumsi anak. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan ibu tentang gizi dengan kejadian obesitas pada anak usia sekolah dasar. Penelitian ini bersifat analitik dengan rancangan studi cross sectional. Populasi penelitian ini adalah siswa kelas 1-3 di SD Islam Al-Azhar 32 Padang dengan subyek penelitian sebanyak 102 orang. Pengambilan data dilakukan dengan pembagian angket kepada ibu yang berisi pertanyaan seputar gizi. Status gizi anak ditentukan dengan pengukuran berat dan tinggi badan. Hasil pengukuran dikategorikan berdasarkan standar antropometri penilaian status gizi anak menurut Departemen Kesehatan Indonesia. Analisis data yang digunakan adalah analisis univariat dan bivariat fisher’s exact test. Hasil penelitian didapatkan subyek obesitas sebanyak 17,6% dengan rerata IMT adalah 16,6 ± 3,20. Tingkat pengetahuan gizi ibu ditemukan hampir seluruhnya dalam kriteria cukup baik, yaitu sebesar 98%. Hasil uji statitik didapatkan bahwa tidak terdapat hubungan bermakna antara pengetahuan gizi ibu dengan kejadian obesitas (p = 0.323Kata kunci: obesitas anak, pengetahuan ibu, giziAbstractObesity is a disorder that is marked by excessive accumulation of body fat. Age group 6-12 years is one group that is at risk of childhood obesity. Mother’s nutritional knowledge is related to childhood obesity. The knowledge influence mother’s decision on child’s daily consumption. The objective of this research was to investigate the relationship between mother’s knowledge of nutrition and childhood obesity among elementary school students.This research was analytic research with cross sectional study. The research

  18. The influence of Mg-Zr master alloy microstructure on the corrosion of Mg

    Gandel, D. S.; Easton, M. A.; Gibson, M. A.; Abbott, T.; Birbilis, N.

    In this study, sixteen Mg-Zr alloys were produced to investigate the role of Zr on corrosion of Mg. Alloys were produced using two different commercial Mg-Zr master alloys commonly used for grain refining Mg, but which contain different Zr particle size distributions. It is seen that the master alloy with a smaller Zr particle size leads to an alloy containing more Zr in solid solution. The ratio of Zr in solid solution and in particle form was observed to have a marked effect on the corrosion of Mg.

  19. Features of Mg2Si Layer Growth in Si/Mg2Si Multilayers

    L.E. Konotopskyi


    Full Text Available Features of magnesium siliced layer growth in Si/Mg2Si multilayers in initial state and after thermal annealing were studied by methods of transmission electron microscopy and X-Ray scattering. As-deposited magnesium silicide layers are amorphous with nanocrystal inclusions of metastable h-Mg2Si. Formation of Mg2Si in hexagonal modification occurs under the influence of stress produced by silicon layers. At T = 723 К Mg2Si layers finished crystallizes in hexagonal modification, with some coarsening of grains. That is accompanied with 7.3 % reduction in period of the Si/Mg2Si multilayer.

  20. Influence of Mg Content on Deformability of AlMg Alloys during Extrusion

    Leśniak D.


    Full Text Available In this study the research on deformability of AlMg alloys with high Mg contents in extrusion was carried out. The different shapes from AlMg alloys containing 3.5%, 4.5% and 5.5% of Mg were extruded on 500 T semi-industrial press by using one-hole and multi-hole flat dies. The extrudates surface quality was under investigations in relation with the temperature-speed parameters of the extrusion process. The metal exit speed was estimated depending on the extrudates shape, wall thickness and Mg content. The alloy’s border solidus and liquidus temperatures were also determined.

  1. Ectopic Expression of Capsicum-Specific Cell Wall Protein Capsicum annuum Senescence-Delaying 1 (CaSD1) Delays Senescence and Induces Trichome Formation in Nicotiana benthamiana

    Seo, Eunyoung; Yeom, Seon-In; Jo, SungHwan; Jeong, Heejin; Kang, Byoung-Cheorl; Choi, Doil


    Secreted proteins are known to have multiple roles in plant development, metabolism, and stress response. In a previous study to understand the roles of secreted proteins, Capsicum annuum secreted proteins (CaS) were isolated by yeast secretion trap. Among the secreted proteins, we further characterized Capsicum annuum senescence-delaying 1 (CaSD1), a gene encoding a novel secreted protein that is present only in the genus Capsicum. The deduced CaSD1 contains multiple repeats of the amino aci...

  2. Studies on the toxic effects of periodontal sustained release drug containing ornidazole and pefloxacin mesylate on early embryonic development of SD rat


    Objective To evaluate the toxic effects of periodontal sustained release drug containing ornidazole and pefloxacin mesylate on early embryonic development of SD rats.Methods A total of 100female SD rats were randomly divided into negative control,low-,medium-,high-dose group and intervention group(20each).Rats in low-,medium-and high-dose group were fed daily with the sustained release drug at 1,4,and 8g/kg respectively;those in negative control group were fed daily with distilled water from ...

  3. Estudio de la cultura organizacional y su influencia en el desempe?o laboral de docentes de la PUCE SD., 2014

    Celi Pinza, Doris Mar?a


    La Pontificia Universidad Cat?lica del Ecuador Sede Santo Domingo (PUCE SD), es una Instituci?n de Educaci?n Superior que ofrece a los estudiantes la posibilidad de formarse profesionalmente, en el marco de una educaci?n humanista e integral, sin distinci?n de g?nero, raza, religi?n o posici?n econ?mica y social; instaurando en ellos, un esp?ritu de pertenencia y trabajo en equipo. La PUCE SD forma parte del Sistema Nacional de la Pontificia Universidad Cat?lica del Ecuador (SI...

  4. Molecular characterization and specific detection of Anaplasma species (AP-sd) in sika deer and its first detection in wild brown bears and rodents in Hokkaido, Japan.

    Moustafa, Mohamed Abdallah Mohamed; Lee, Kyunglee; Taylor, Kyle; Nakao, Ryo; Sashika, Mariko; Shimozuru, Michito; Tsubota, Toshio


    A previously undescribed Anaplasma species (herein referred to as AP-sd) has been detected in sika deer, cattle and ticks in Japan. Despite being highly similar to some strains of A. phagocytophilum, AP-sd has never been detected in humans. Its ambiguous epidemiology and the lack of tools for its specific detection make it difficult to understand and interpret the prevalence of this Anaplasma species. We developed a method for specific detection, and examined AP-sd prevalence in Hokkaido wildlife. Our study included 250 sika deer (Cervus nippon yesoensis), 13 brown bears (Ursus arctos yesoensis) and 252 rodents including 138 (Apodemus speciosus), 45 (Apodemus argenteus), 42 (Myodes rufocanus) and 27 (Myodes rutilus) were collected from Hokkaido island, northern Japan, collected during 2010 to 2015. A 770 bp and 382 bp segment of the 16S rRNA and gltA genes, respectively, were amplified by nested PCR. Results were confirmed by cloning and sequencing of the positive PCR products. A reverse line blot hybridization (RLB) based on the 16S rRNA gene was then developed for the specific detection of AP-sd. The prevalence of AP-sd by nested PCR in sika deer was 51% (128/250). We detected this Anaplasma sp. for the first time in wild brown bears and rodents with a prevalence of 15% (2/13) and 2.4% (6/252), respectively. The sequencing results of the 16S rRNA and gltA gene amplicons were divergent from the selected A. phagocytophilum sequences in GenBank. Using a newly designed AP-sd specific probe for RLB has enabled us to specifically detect this Anaplasma species. Besides sika deer and cattle, wild brown bears and rodents were identified as potential reservoir hosts for AP-sd. This study provided a high throughput molecular method that specifically detects AP-sd, and which can be used to investigate its ecology and its potential as a threat to humans in Japan.

  5. Evaluation of a Commercial SD Dengue Virus NS1 Antigen Capture Enzyme-Linked Immunosorbent Assay Kit for Early Diagnosis of Dengue Virus Infection▿

    Wang, Seok Mui; Sekaran, Shamala Devi


    Early definitive diagnosis of dengue virus infection may help in the timely management of dengue virus infection. We evaluated the Standard Diagnostics (SD, South Korea) dengue virus nonstructural protein NS1 antigen enzyme-linked immunosorbent assay (SD dengue NS1 Ag ELISA) for the detection of dengue virus NS1 antigen in patients' sera, using a total of 399 serum samples in a comparison with real-time reverse transcription (RT)-PCR, an in-house IgM capture (MAC)-ELISA, and a hemagglutinatio...

  6. Elevated temperature properties of Mg- 12Li-Al-MgO composites

    WEI Xiao-wei; HUANG Qing-min


    The compressive creep of Mg-12Li-Al-MgO particulate composites was investigated, which were produced by the reaction of reinforcement materials (B2O3) with Mg-12Li-Al alloy melt in the temperature range of 100-190 ℃ and under different compressive stress in the range of 40-70 MPa with special apparatus. The content of MgO particulates is about 0, 5%, 10%,15%(volume fraction) in Mg-12Li-Al alloy respectively. The results reveal that the creep resistance of the particulate composites is increased with increasing the content of MgO particulates and considerable improvementin creep resistance is observed in Mg-12Li-Al-MgO composites. However, over all range of temperatures and stresses, the creep data for these composites can be correlated using an empirical equation εs =Aσnexp(-Q/RT), where n is 4.93 and Q is about 78.1 kJ/mol for Mg-14Li-Al alloy and n is between 7.48 and 9.47 and Q is 111.2-137.3 kJ/mol for Mg-12Li-Al-MgO composites. The different compressive creep behavior of the composites is associated with the different material constant A. The compressive creep rate is controlled by the lattice diffusion of Li and dislocation climb.

  7. Ultrafast Synthesis and Related Phase Evolution of Mg2Si and Mg2Sn Compounds

    Zhang, Qiang; Lu, Qiangbing; Yan, Yonggao; Su, Xianli; Tang, Xinfeng


    Both Mg2Si and Mg2Sn compounds were synthesized by an ultra-fast self-propagating high-temperature synthesis (SHS) method. The data regarding SHS were obtained via theoretical calculation combined with experiments, showing that the adiabatic temperature T ad and ignition temperature T ig of Mg2Si are a little higher than those of Mg2Sn. The mechanism of phase evolution and the concomitant microstructure evolution during the synthesis process of Mg2Si and Mg2Sn compounds were investigated by adopting SHS technique coupled with a sudden quenching treatment. Differential scanning calorimetry (DSC), field emission scanning electron microscopy (FESEM), and x-ray powder diffraction (XRD) results indicate that Mg2Si compound can be directly synthesized through the reaction of Mg and Si elements at around 850 K. Correspondingly, the formation of Mg2Sn needs to undergo melting of Sn and the subsequent feeble reaction between Mg and Sn elements before the large scale transformation at 730 K. As the groundwork, this research embodies great significance for future study on the ultrafast SHS process of the ternary Mg2Si1-x Sn x solid solutions.

  8. Formation and Corrosion Resistance of Mg-Al Hydrotalcite Film on Mg-Gd-Zn Alloy

    Ba, Z. X.; Dong, Q. S.; Kong, S. X.; Zhang, X. B.; Xue, Y. J.; Chen, Y. J.


    An environment-friendly technique for depositing a Mg-Al hydrotalcite (HT) (Mg6Al2(OH)16-CO3ṡ4H2O) conversion film was developed to protect the Mg-Gd-Zn alloy from corrosion. The morphology and chemical compositions of the film were analyzed by scanning electronic microscope (SEM) equipped with energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD) and Raman spectroscopy (RS), respectively. The electrochemical test and hydrogen evolution test were employed to evaluate the biocorrosion behavior of Mg-Gd-Zn alloy coated with the Mg-Al HT film in the simulated body fluid (SBF). It was found that the formation of Mg-Al HT film was a transition from amorphous precursor to a crystalline HT structure. The HT film can effectively improve the corrosion resistance of magnesium alloy. It indicates that the process provides a promising approach to modify Mg-Gd-Zn alloy.

  9. The effects of diagenesis and dolomitization on Ca and Mg isotopes in marine platform carbonates: Implications for the geochemical cycles of Ca and Mg

    Fantle, Matthew S.; Higgins, John


    The Ca, Mg, O, and C isotopic and trace elemental compositions of marine limestones and dolostones from ODP Site 1196A, which range in depth (∼58 to 627 mbsf) and in depositional age (∼5 and 23 Ma), are presented. The objectives of the study are to explore the potential for non-traditional isotope systems to fingerprint diagenesis, to quantify the extent to which geochemical proxies are altered during diagenesis, and to investigate the importance of diagenesis within the global Ca and Mg geochemical cycles. The data suggest that Ca, which has a relatively high solid to fluid mass ratio, can be isotopically altered during diagenesis. In addition, the alteration of Ca correlates with the alteration of Mg in such a way that both can serve as useful tools for deciphering diagenesis in ancient rocks. Bulk carbonate δ44Ca values vary between 0.60 and 1.31‰ (SRM-915a scale); the average limestone δ44Ca is 0.97 ± 0.24‰ (1SD), identical within error to the average dolostone (1.03 ± 0.15 1SD ‰). Magnesium isotopic compositions (δ26Mg, DSM-3 scale) range between -2.59‰ and -3.91‰, and limestones (-3.60 ± 0.25‰) and dolostones (-2.68 ± 0.07‰) are isotopically distinct. Carbon isotopic compositions (δ13C, PDB scale) vary between 0.86‰ and 2.47‰, with average limestone (1.96 ± 0.31‰) marginally offset relative to average dolostone (1.68 ± 0.57‰). The oxygen isotopic compositions (δ18O, PDB scale) of limestones (-1.22 ± 0.94‰) are substantially lower than the dolostones measured (2.72 ± 1.07‰). The isotopic data from 1196A suggest distinct and coherent trends in isotopic and elemental compositions that are interpreted in terms of diagenetic trajectories. Numerical modeling supports the contention that such trends can be interpreted as diagenetic, and suggests that the appropriate distribution coefficient (KMg) associated with limestone diagenesis is ∼1 to 5 × 10-3, distinctly lower than those values (>0.015) reported in laboratory

  10. Melting relations in the MgO-MgSiO3 system up to 70 GPa

    Ohnishi, Satoka; Kuwayama, Yasuhiro; Inoue, Toru


    Melting experiments in a binary system MgO-MgSiO3 were performed up to 70 GPa using a CO2 laser heated diamond anvil cell. The quenched samples were polished and analyzed by a dualbeam focused ion beam (FIB) and a field emission scanning electron microscope (FE-SEM), respectively. The liquidus phase and the eutectic composition were determined on the basis of textual and chemical analyses of sample cross sections. Our experimental results show that the eutectic composition is the Si/Mg molar ratio of 0.76 at 35 GPa and it decreases with increasing pressure. Above 45 GPa, it becomes relatively constant at about 0.64-0.65 Si/Mg molar ratio. Using our experimental data collected at a wide pressure range up to 70 GPa together with previous experimental data, we have constructed a thermodynamic model of the eutectic composition of the MgO-MgSiO3 system. The eutectic composition extrapolated to the pressure and temperature conditions at the base of the mantle is about 0.64 Si/Mg molar ratio. The modeled eutectic composition is quite consistent with a previous prediction from ab initio calculations (de Koker et al. in Earth Planet Sci Lett 361:58-63, 2013), suggesting that the simple assumption of a non-ideal regular solution model can well describe the melting relation of the MgO-MgSiO3 system at high pressure. Our results show that the liquidus phase changes from MgO-periclase to MgSiO3-bridgmanite at 35 GPa for the simplified pyrolite composition ( 0.7 Si/Mg molar ratio), while MgSiO3-bridgmanite is the liquidus phase at the entire lower mantle conditions for the chondritic composition ( 0.84 Si/Mg molar ratio).

  11. The APC Gene Immunohistochemical Research of Colorectal Adenoma-carcinoma Sequence Model Tissue in SD Rats%大鼠结直肠腺瘤—癌序列模型的APC蛋白表达及意义

    宋伟; 张曹; 李海; 杨银学; 屈玉玲


    目的 探讨SD大鼠结直肠“腺瘤-癌”序列模型不同病变阶段正常组织、腺瘤和癌变组织中结肠腺瘤性息肉病基因(adenomatous polyposis coli,APC)蛋白表达水平的变化.方法 采用1,2-二甲基肼盐建立结直肠“腺瘤-癌”序列动物模型.按30mg·kg-1体质量,每周皮下注射1次,连续注射20周.造模完成后取同时存在正常、腺瘤和癌组织的30例SD大鼠结直肠组织标本,用免疫组化染色方法检测APC蛋白的表达水平.结果 APC阳性表达率在癌、腺瘤、正常组织中均不同(P<0.05);APC阳性率正常组高于腺瘤组和癌变组,腺瘤组高于癌变组(P <0.0125).免疫染色结果显示,在腺瘤-癌序列进展过程中,阳性细胞数与染色强度逐渐下降.结论 SD大鼠“腺瘤-癌”序列动物模型中,APC蛋白在不同阶段表达水平不同,可作为预测结直肠癌发生的早期肿瘤标志物.

  12. Hydrodechlorination of Tetrachloromethane over Palladium Catalysts Supported on Mixed MgF₂-MgO Carriers.

    Bonarowska, Magdalena; Wojciechowska, Maria; Zieliński, Maciej; Kiderys, Angelika; Zieliński, Michał; Winiarek, Piotr; Karpiński, Zbigniew


    Pd/MgO, Pd/MgF₂ and Pd/MgO-MgF₂ catalysts were investigated in the reaction of CCl₄ hydrodechlorination. All the catalysts deactivated in time on stream, but the degree of deactivation varied from catalyst to catalyst. The MgF₂-supported palladium with relatively large metal particles appeared the best catalyst, characterized by good activity and selectivity to C₂-C₅ hydrocarbons. Investigation of post-reaction catalyst samples allowed to find several details associated with the working state of hydrodechlorination catalysts. The role of support acidity was quite complex. On the one hand, a definite, although not very high Lewis acidity of MgF₂ is beneficial for shaping high activity of palladium catalysts. The MgO-MgF₂ support characterized by stronger Lewis acidity than MgF₂ contributes to very good catalytic activity for a relatively long reaction period (~5 h) but subsequent neutralization of stronger acid centers (by coking) eliminates them from the catalyst. On the other hand, the role of acidity evolution, which takes place when basic supports (like MgO) are chlorided during HdCl reactions, is difficult to assess because different events associated with distribution of chlorided support species, leading to partial or even full blocking of the surface of palladium, which plays the role of active component in HdCl reactions.

  13. An Analysis on Teachers' Politeness Strategy and Student's Compliance in Teaching Learning Process at SD Negeri 024184 Binjai Timur Binjai--North Sumatra-Indonesia

    Manik, Sondang; Hutagaol, Juniati


    This study aims to find out the politeness strategies used by the teachers and how the politeness affects to the student's compliance. The focus is on directive and expressive speech acts. The subjects of this study were two teachers and the students of class II-A and II-B at SD 024184 Binjai Timur Binjai. The data was gathered by video audio…

  14. Orbital properties of an unusually low-mass sdB star in a close binary system with a white dwarf

    Silvotti, R; Bloemen, S; Telting, J H; Heber, U; Oreiro, R; Reed, M D; Farris, L E; O'Toole, S J; Lanteri, L; Degroote, P; Hu, H; Baran, A S; Hermes, J J; Althaus, L G; Marsh, T R; Charpinet, S; Li, J; Morris, R L; Sanderfer, D T


    We have used 605 days of photometric data from the Kepler spacecraft to study KIC 6614501, a close binary system with an orbital period of 0.15749747(25) days (3.779939 hours), that consists of a low-mass subdwarf B (sdB) star and a white dwarf. As seen in many other similar systems, the gravitational field of the white dwarf produces an ellipsoidal deformation of the sdB which appears in the light curve as a modulation at two times the orbital frequency. The ellipsoidal deformation of the sdB implies that the system has a maximum inclination of \\sim40 degrees, with i \\approx 20\\degrees being the most likely. The orbital radial velocity of the sdB star is high enough to produce a Doppler beaming effect with an amplitude of 432 \\pm 5 ppm, clearly visible in the folded light curve. The photometric amplitude that we obtain, K1 = 85.8 km/s, is \\sim 12 per cent less than the spectroscopic RV amplitude of 97.2 \\pm 2.0 km/s. The discrepancy is due to the photometric contamination from a close object at about 5 arcse...

  15. Evaluation of SD BIOLINE Syphilis 3.0 for rapid diagnosis of syphilis: Report from a regional sexually transmitted infection reference laboratory in North India

    Bhanu Mehra


    Conclusion: Keeping in view the high sensitivity and specificity of SD BIOLINE Syphilis 3.0, we conclude that the test can be used as a tool for rapid on-site diagnosis of syphilis and as an alternative to TPHA for detection of antibodies to Treponema pallidum.

  16. Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera

    Keiichiro Akeo


    Full Text Available Purpose. To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS. Methods. A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA, full-field electroretinograms (ERGs, and multifocal ERGs (mfERGs. Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT, and adaptive optics (AO fundus imaging. After the baseline clinical data were obtained, topical dorzolamide was applied to the patient. The patient was followed for 24 months. Results. A reported RS1 gene mutation was found (P203L in the patient. At the baseline, his decimal BCVA was 0.15 in the right and 0.3 in the left eye. Fundus photographs showed bilateral spoke wheel-appearing maculopathy. SD-OCT confirmed the foveoschisis in the left eye. The AO images of the left eye showed spoke wheel retinal folds, and the folds were thinner than those in fundus photographs. During the follow-up period, the foveal thickness in the SD-OCT images and the number of retinal folds in the AO images were reduced. Conclusions. We have presented the detailed morphological changes of foveoschisis in a patient with XLRS detected by SD-OCT and AO fundus camera. However, the findings do not indicate whether the changes were influenced by topical dorzolamide or the natural history.

  17. Planning and implementation of the on-comet operations of the instrument SD2 onboard the lander Philae of Rosetta mission

    Di Lizia, P.; Bernelli-Zazzera, F.; Ercoli-Finzi, A.; Mottola, S.; Fantinati, C.; Remetean, E.; Dolives, B.


    The lander Philae of the Rosetta mission landed on the surface of the comet 67 P/Churyumov-Gerasimenko on November 12, 2014. Among the specific subsystems and instruments carried on Philae, the sampling, drilling and distribution (SD2) subsystem had the role of providing in-situ operations devoted to soil drilling, sample collection, and their distribution to three scientific instruments. After landing, a first sequence of scientific activities was carried out, relying mainly on the energy stored in the lander primary battery. Due to the limited duration and the communication delay, these activities had to be carried out automatically, with a limited possibility of developing and uploading commands from the ground. Philae's landing was not nominal and SD2 was operated in unexpected conditions: the lander was not anchored to the soil and leant on the comet surface shakily. Nevertheless, one sampling procedure was attempted. This paper provides an overview of SD2 operation planning and on-comet operations, and analyses SD2 achievements during the first science sequence of Philae's on-comet operations.


    Valentin ARAPU


    Full Text Available Gubernatorul Basarabiei S.D. Urusov a soluționat „chestiunea armenească” pe cale amiabilă. Armenii basarabeni au acceptat să cedeze statului rus o parte din bani și proprietăți, păstrându-și intacte privilegiile și statutul de odinioară. În Basarabia, spre deosebire de alte gubernii în care au existat tensiuni în acest sens, grație unei politici abile și tolerante, promovate față de armeni de către S.D. Urusov, procesul de expropriere parțială a comunității armenești s-a desfășurat calm și fără excese.SETTLEMENT OF THE „ARMENIAN ISSUE” BY THE GOVERNOR OF BESSARABIA S.D. URUSOV (1903-1904The governor of Bessarabia S.D. Urusov settled the „Armenian issue” in an amicable way. Armenians from Bessarabiaagreed to cede to Russian state some money and properties, in order to keep intact the privileges and status they held. In Bessarabia, unlike other gubernias, where there were tensions in this regard, thanks to skilful and tolerant policy, promoted by S.D. Urusov, the process of partial expropriation of the Armenian community was held calmly and without excesses.

  19. GTC/OSIRIS observations of RWT 152, a case study of a planetary nebula with an sdO central star

    Aller, A; Olguín, L; Solano, E; Ulla, A


    RWT 152 is one of the few planetary nebula with an sdO central star. We present subarcsecond red tunable filter imaging and intermediate-resolution, long-slit spectroscopy of RWT 152, obtained with OSIRIS/GTC, which allow us to describe in detail its morphology and to obtain its physical conditions and chemical abundances.

  20. Cordycepin Down-Regulates Multiple Drug Resistant (MDR/HIF-1α through Regulating AMPK/mTORC1 Signaling in GBC-SD Gallbladder Cancer Cells

    Wei-Ding Wu


    Full Text Available Gallbladder cancer is the most common malignancy of the bile duct, with low 5-year survival rate and poor prognosis. Novel effective treatments are urgently needed for the therapy of this disease. Here, we showed that cordycepin, the bioactive compound in genus Cordyceps, induced growth inhibition and apoptosis in cultured gallbladder cancer cells (Mz-ChA-1, QBC939 and GBC-SD lines. We found that cordycepin inhibited mTOR complex 1 (mTORC1 activation and down-regulated multiple drug resistant (MDR/hypoxia-inducible factor 1α (HIF-1α expression through activating of AMP-activated protein kinase (AMPK signaling in gallbladder cancer GBC-SD cells. Contrarily, AMPKα1-shRNA depletion dramatically inhibited cordycepin-induced molecular changes as well as GBC-SD cell apoptosis. Further, our results showed that co-treatment with a low concentration cordycepin could remarkably enhance the chemosensitivity of GBC-SD cells to gemcitabine and 5-fluorouracil (5-FU, and the mechanism may be attributed to AMPK activation and MDR degradation. In summary, cordycepin induces growth inhibition and apoptosis in gallbladder cancer cells via activating AMPK signaling. Cordycepin could be a promising new drug or chemo-adjuvant for gallbladder cancer.

  1. Preparation of Metallic Isotope 26Mg

    WuXiaolei; ZhangFuming; GanZaiguo; GuoJunsheng; QinZhi


    Some special isotope material is usually used in nuclear experiments. It can be served as ion beam or target. When new superheavy nuclide 265Bh (Z=107) is synthesized, a reaction of 243Am target with 26Mg ion beamis selected to produce new isotope 265Bh. The preparation and production of this rare and extremely expensive isotope 26 Mg used for ion beam substance will be a key problem in synthesizing experiment of 265Bh. Theavailable chemical form of isotope 26Mg in commercial product usually is oxide or other compound, which are not required in our experiment. They need to be transformed to metal form as a proper working substance in ion source.

  2. Hydrogenation properties of Mg-Al alloys

    Andreasen, Anders


    In this paper the properties of Mg-Al alloys in relation to hydrogen storage are reviewed. The main topics of this paper are materials preparation, hydrogen capacity, thermodynamics of hydride formation, and the kinetics of hydride formation and decomposition. Hydrogenation of Mg-Al leads...... to disproportionation with the formation of magnesium hydride and metallic aluminum as the final product. Experimental evidence renders this process reversible. It is observed that the enthalpy of hydride formation of magnesium is lowered upon alloying with Al due to a slightly endothermic disproportionation reaction....... Further, it is found that the kinetics of hydrogenation, as well dehydrogenation, may be significantly improved by alloying compared to pure Mg. The expense of these improvements of the hydrogenation/dehydrogenation properties is a lower gravimetric hydrogen density in the hydrogenated product, (C) 2008...

  3. High Spin States in ^24Mg

    Schwartz, J.; Lister, C. J.; Wuosmaa, A.; Betts, R. R.; Blumenthal, D.; Carpenter, M. P.; Davids, C. N.; Fischer, S. M.; Hackman, G.; Janssens, R. V. F.


    The ^12C(^16O,α)^24Mg reaction was used at 51.5MeV to populate high angular momentum states in ^24Mg. Gamma-rays de-exciting high spin states were detected in a 20 detector spectrometer (the AYE-ball) triggered by the ANL Fragment Mass Analyser (FMA). Channel selection, through detection of ^24Mg nuclei with the appropriate time of flight, was excellent. All the known decays from high spin states were seen in a few hours, with the exception of the 5.04 MeV γ-decay of the J^π=9^- state at 16.904 MeV footnote A.E.Smith et al., Phys. Lett. \\underlineB176, (1986)292. which could not be confirmed. The potential of the technique for studying the radiative decay of states with very high spin in light nuclei will be discussed.

  4. Phase equilibrium in Mg-Cu-Y

    Mezbahul-Islam, Mohammad; Medraj, Mamoun


    Magnesium-based bulk metallic glasses (BMG) have potential in applications ranging from biomedical to sports equipment and the Mg-Cu-Y system offers some of the most promising alloys. Phase relations and ternary solubility of the binary and ternary compounds of this system have been experimentally investigated. The Isothermal section of Mg-Cu-Y system at 673 K for the entire composition range has been constructed. Phase relations in the Cu-rich (>66 at.% Cu) region of the Mg-Cu-Y system has been determined for the first time. The homogeneity range of three ternary compounds has been determined. Solidifications behavior of several key alloys have been discussed based on the differential scanning calorimetry (DSC) experiments and thermodynamic calculations. Extensive analysis of the DSC curves has been carried out to relate them to the corresponding phase transformation reactions and temperatures. Some of the most promising metallic glass forming regions have been analyzed using thermodynamic calculations.

  5. Low-dose (2.5 mg/day) finasteride treatment in hirsutism.

    Bayram, F; Müderris, I; Güven, M; Ozçelik, B; Keleştimur, F


    This study was performed to confirm the therapeutic effects of low-dose, (2.5 mg/day) finasteride in hirsute women. Our study was a non-randomized prospective clinical trial. Twenty-nine patients with hirustism were included in the study. The patients received 2.5 mg finasteride once a day over a period of 12 months. Follicle stimulating hormone, luteinizing hormone, sex hormone binding globulin, 17 alpha-hydroxyprogesterone, estradiol, androstenedione, total and free testosterone, dehydroepiandrosterone sulfate levels and hirsutism scores were determined in all patients before treatment and at every 6 months during the therapy. The hirsutism score decreased from a mean of 18.4 +/- 4.6 to 8.4 +/- 4.2 during the study. The per cent reduction in hirsutism score (mean +/- SD) at 6 and 12 months was 29.2 +/- 14.5 and 55.7 +/- 14.9%, respectively. There were no significant differences in any of the hormone levels and no serious side-effects were observed during the treatment. In conclusion, low-dose finasteride (2.5 mg/day) is a cost-effective, well-tolerated therapeutic agent without significant abnormal biochemical findings and can be used in place of high-dose (5 mg/day) finasteride in the treatment of hirsutism.

  6. Superconductivity in MgB2


    In January of 2001 the superconductivity of the compound MgB2 with a critical temperature Tc of up to 39 K was discovered. This Tc is the highest in all intermetallic compound and alloy superconductors. MgB2 has a simple structure and its manufacturing capital cost is lower, therefore it could become a practical superconductor in the future. The recent progress is reviewed here which covers the progress in electronic structure, high Tc mechanism, superconducting parameters (Debye temperature, specific heat coefficient of electron, critical fields, coherent length, penetration depth, energy gap, critical current and relaxation rate of flux). Moreover the issue on power transmission is discussed.

  7. Electron microscopy observations of MgB 2 wire prepared by an internal Mg diffusion method

    Shimada, Y.; Kubota, Y.; Hata, S.; Ikeda, K.; Nakashima, H.; Matsumoto, A.; Togano, K.; Kumakura, H.


    Microstructure in a high-density MgB2 wire fabricated by an internal Mg diffusion (IMD) process has been investigated by electron microscopy imaging and analysis at different scales. In the IMD process, a pure Mg rod was used as Mg source, and nanosized SiC powders were mixed with amorphous B powders. In the case of a heat treatment at 640 °C for 1 h carried out after rolling and drawing processes, the wire has two microstructural features that degrade critical current density: uncrystallized zones composed mainly of unreacted B and SiC powders, and cracks partly filled with course Mg2Si crystals. Those cracks were formed in the uncrystallized zones as well as in crystallized MgB2 zones. It indicate that the cracks formed by the mechanical milling and drawing remain after the heat treatment.

  8. Vitamin K prophylaxis for premature infants: 1 mg versus 0.5 mg.

    Costakos, Dennis T; Greer, Frank R; Love, Laureen A; Dahlen, Lynn R; Suttie, John W


    We studied babies (22 to 32 weeks gestational age) of mothers wishing to breast-feed. Group 1 received 1 mg of vitamin K and Group 2 received 0.5 mg of vitamin K. The Day 2 plasma levels of vitamin K were 1900 to 2600 times higher on average, and the Day 10 vitamin K levels 550 to 600 times higher on average, relative to normal adult plasma values, whether an initial prophylaxis dose of 0.5 mg or 1 mg was used. We conclude that 0.5 mg as the initial dose of vitamin K intramuscularly or intravenously would likely be more than adequate to prevent hemorrhagic disease of the newborn, and that 0.3 mg/per kg may be used for babies with birth weights below 1000 g. To decrease vitamin K intakes in this population, new preparations of total parenteral nutrition multivitamins are needed.

  9. Efficient hydrogen storage with the combination of lightweight Mg/MgH2 and nanostructures.

    Cheng, Fangyi; Tao, Zhanliang; Liang, Jing; Chen, Jun


    Efficient hydrogen storage plays a key role in realizing the incoming hydrogen economy. However, it still remains a great challenge to develop hydrogen storage media with high capacity, favourable thermodynamics, fast kinetics, controllable reversibility, long cycle life, low cost and high safety. To achieve this goal, the combination of lightweight materials and nanostructures should offer great opportunities. In this article, we review recent advances in the field of chemical hydrogen storage that couples lightweight materials and nanostructures, focusing on Mg/MgH(2)-based systems. Selective theoretical and experimental studies on Mg/MgH(2) nanostructures are overviewed, with the emphasis on illustrating the influences of nanostructures on the hydrogenation/dehydrogenation mechanisms and hydrogen storage properties such as capacity, thermodynamics and kinetics. In particular, theoretical studies have shown that the thermodynamics of Mg/MgH(2) clusters below 2 nm change more prominently as particle size decreases.

  10. Lupeol induces apoptosis and inhibits invasion in gallbladder carcinoma GBC-SD cells by suppression of EGFR/MMP-9 signaling pathway.

    Liu, Yan; Bi, Tingting; Shen, Genhai; Li, Zhimin; Wu, Guoliang; Wang, Zheng; Qian, Liqiang; Gao, Quangen


    The cytostatic drug from fruits and other plant derived products have acted as a chemotherapeutic agent used in treatment of a wide variety of cancers. Lupeol, a dietary triterpene, present in many fruits and medicinal plants, has been shown to possess many pharmacological properties including anti-cancer effect in both in vitro and in vivo assay systems. However, the cancer proliferative and invasive inhibitory effects and molecular mechanisms on gallbladder carcinoma GBC-SD cells have not been studied. In the present study, GBC-SD cells were treated by lupeol and subjected to methyl thiazolyl tetrazolium analysis, Hoechst 33342 staining, annexin V/propidium iodide double-staining, transwell chamber assay and Western blot analysis. In addition, GBC-SD xenograft tumors were established in male nude BALB/c mice, and lupeol was intravenously administered to evaluate the anti-cancer capacity in vivo. Our results showed that lupeol inhibited the proliferation, migration, invasion and induced apoptosis of GBC-SD cells in a dose-dependent manner in vitro. Furthermore, the expression of p-EGFR, p-AKT and MMP-9 levels were significantly down-regulated. These protein interactions may play a pivotal role in the regulation of apoptosis and invasion. More importantly, our in vivo studies showed that administration of lupeol decreased tumor growth in a dose-dependent manner. Immunohistochemistry analysis demonstrated the down-regulation of p-EGFR and MMP-9 in tumor tissues following lupeol treatment, consistent with the in vitro results. Taken together, our findings indicated that lupeol can induce apoptotic cell death and inhibit the migration as well as invasion of GBC-SD cells. The mechanism may be associated with the suppression of EGFR/MMP-9 signaling. These results might offer a therapeutic potential advantage for human gallbladder carcinoma chemoprevention or chemotherapy.

  11. Automated geographic atrophy segmentation for SD-OCT images using region-based C-V model via local similarity factor.

    Niu, Sijie; de Sisternes, Luis; Chen, Qiang; Leng, Theodore; Rubin, Daniel L


    Age-related macular degeneration (AMD) is the leading cause of blindness among elderly individuals. Geographic atrophy (GA) is a phenotypic manifestation of the advanced stages of non-exudative AMD. Determination of GA extent in SD-OCT scans allows the quantification of GA-related features, such as radius or area, which could be of important value to monitor AMD progression and possibly identify regions of future GA involvement. The purpose of this work is to develop an automated algorithm to segment GA regions in SD-OCT images. An en face GA fundus image is generated by averaging the axial intensity within an automatically detected sub-volume of the three dimensional SD-OCT data, where an initial coarse GA region is estimated by an iterative threshold segmentation method and an intensity profile set, and subsequently refined by a region-based Chan-Vese model with a local similarity factor. Two image data sets, consisting on 55 SD-OCT scans from twelve eyes in eight patients with GA and 56 SD-OCT scans from 56 eyes in 56 patients with GA, respectively, were utilized to quantitatively evaluate the automated segmentation algorithm. We compared results obtained by the proposed algorithm, manual segmentation by graders, a previously proposed method, and experimental commercial software. When compared to a manually determined gold standard, our algorithm presented a mean overlap ratio (OR) of 81.86% and 70% for the first and second data sets, respectively, while the previously proposed method OR was 72.60% and 65.88% for the first and second data sets, respectively, and the experimental commercial software OR was 62.40% for the second data set.

  12. Mifepristone 5 mg versus 10 mg for emergency contraception: double-blind randomized clinical trial

    Carbonell JL


    Full Text Available Josep Lluis Carbonell,1 Ramon Garcia,2 Adriana Gonzalez,2 Andres Breto,2 Carlos Sanchez2 1Mediterranea Medica Clinic, Valencia, Spain; 2Eusebio Hernandez Gynecology and Obstetrics Teaching Hospital, Havana, Cuba Purpose: To estimate the efficacy and safety of 5 mg and 10 mg mifepristone for emergency contraception up to 144 hours after unprotected coitus. Methods: This double-blind randomized clinical trial was carried out at Eusebio Hernandez Hospital (Havana, Cuba. A total of 2,418 women who requested emergency contraception after unprotected coitus received either 5 mg or 10 mg mifepristone. The variables for assessing efficacy were the pregnancies that occurred and the fraction of pregnancies that were prevented. Other variables assessed were the side effects of mifepristone, vaginal bleeding, and changes in the date of the following menstruation. Results: There were 15/1,206 (1.2% and 9/1,212 (0.7% pregnancies in the 5 mg and 10 mg group, respectively (P=0.107. There were 88% and 93% prevented pregnancies in the 5 mg and 10 mg group, respectively. The side effect profiles were similar in both groups. Delayed menstruation ≥7 days was experienced by 4.9% and 11.0% of subjects in the 5 mg and 10 mg group, respectively (P=0.001. There was a significant high failure rate for women weighing >75 kg in the 5 mg group. Conclusion: It would be advisable to use the 10 mg dose of mifepristone for emergency contraception as there was a trend suggesting that the failure rate of the larger dose was lower. Keywords: mifepristone, emergency contraception

  13. The reactive Mg-liquid infiltration to obtain long superconducting MgB$_{2}$ cables

    Giunchi, G


    An alternative “in situ” process to the MgB2 wire manufacturing is represented by the Reactive Mg-Liquid Infiltration (Mg-RLI) process [1], in which the precursor wire is constituted by a metallic sheath encasing a central Mg rod, surrounded by the B powders. We demonstrated that this peculiar “internal Mg” assembly is able to produce very dense superconducting material of high critical current density, with an acceptable fill factor, up to 0.28. Furthermore the Mg-RLI allows also to easily dope the MgBB2 material either by carbon or nanoSiC powders. In order to realize long cables with this technique, two different approaches may be applied. The first one relies on the assembly of thin wires, fine enough that the liquid Mg cannot freely percolate along the wire during the reaction, and the second one relies on the assembly of thick hollow wires, reacted with a continuous supply of Mg to avoid deficiency of Mg in some part of the precursor wire. Both techniques have been demonstrated feasible and the ...

  14. The Interplay of Al and Mg Speciation in Advanced Mg Battery Electrolyte Solutions.

    See, Kimberly A; Chapman, Karena W; Zhu, Lingyang; Wiaderek, Kamila M; Borkiewicz, Olaf J; Barile, Christopher J; Chupas, Peter J; Gewirth, Andrew A


    Mg batteries are an attractive alternative to Li-based energy storage due to the possibility of higher volumetric capacities with the added advantage of using sustainable materials. A promising emerging electrolyte for Mg batteries is the magnesium aluminum chloride complex (MACC) which shows high Mg electrodeposition and stripping efficiencies and relatively high anodic stabilities. As prepared, MACC is inactive with respect to Mg deposition; however, efficient Mg electrodeposition can be achieved following an electrolytic conditioning process. Through the use of Raman spectroscopy, surface enhanced Raman spectroscopy, (27)Al and (35)Cl nuclear magnetic resonance spectroscopy, and pair distribution function analysis, we explore the active vs inactive complexes in the MACC electrolyte and demonstrate the codependence of Al and Mg speciation. These techniques report on significant changes occurring in the bulk speciation of the conditioned electrolyte relative to the as-prepared solution. Analysis shows that the active Mg complex in conditioned MACC is very likely the [Mg2(μ-Cl)3·6THF](+) complex that is observed in the solid state structure. Additionally, conditioning creates free Cl(-) in the electrolyte solution, and we suggest the free Cl(-) adsorbs at the electrode surface to enhance Mg electrodeposition.

  15. Effect of Ni on Mg based hydrogen storage alloy Mg3Nd

    TONG Yanqing; OUYANG Liuzhang; ZHU Min


    Magnesium-neodymium based alloys were prepared by induction melting in an alumina crucible under protection of pure argon atmosphere. XRD patterns show that the as-melted Mg-Nd and Mg3NdNi 0.1 diffraction peaks can be excellently indexed with D03 structure (BiF3 type, space group Fm3m ). The lattice constant of Mg3Nd phase is 0.7390 nm, which is determined by XRD analysis using Cohen's extrapolation method. The reversible hydrogen storage capacity reaches 1.95wt.% for Mg3Nd and 2.68wt.% for Mg3NdNi0.1 . The desorption of hydrogen takes place at 291 ℃ for Mg3Nd and at 250 ℃ for Mg3NdNi 0.1 . The alloys could absorb hydrogen at room temperature with rapid hydriding and dehydriding kinetics after only one cycle. The enthalpy (ΔH ) and entropy (ΔS ) of Mg3Nd-H dehydriding reaction were -68.2 kJ·mol-1 H2 and -0.121 kJ·(K·mol)-1 H2 determined by using van't Hoff plot according to the pressure-composition-isotherms (P-C-I) curve measured at different temperatures. Hydrogen absorption kinetic property of Mg3NdNi 0.1 alloy was also measured at room temperature.

  16. Comparing Doping Methodologies in Mg2Si/AgMg System

    Polymeris, G. S.; Theodorakakos, A.; Mars, K.; Godlewska, E.; Lioutas, Ch. B.; Hatzikraniotis, E.; Paraskevopoulos, K. M.


    Morphological and optical characterizations for the Mg2Si samples doped with Ag are presented. Two different doping methodologies with silver, namely in situ and ex situ doping, were studied for the case of Mg2Si of self-propagating high-temperature synthesis. Electron microscopy measurements in both scanning and transmission configurations verified the presence of AgMg precipitates embedded in the Mg2Si matrix and similar results were also yielded by FTIR spectroscopy. Finally, the dependence of silver content in both forms of dopant and inter-metallic constituent is studied upon doping technology.

  17. Confinement of Mg-MgH2 systems into carbon nanotubes changes hydrogen sorption energetics.

    Liang, Jian-jie; Kung, W-C Paul


    The density functional theory (DFT) method was used to study the effect of nanoconfinement on the energetics of Mg-MgH2 systems. Varying levels of loading of the Mg/MgH2 particles into a (10,10) carbon nanotube were examined, and the corresponding energetics were computed. A clear trend was observed that, as the level of loading increases (increasing confinement), the net energy change in the hydrogen sorption/desorption processes decreases to a significant level when the loading approaches the maximum. The confinement was found not to depend on the tube length of the confining nanotubes.

  18. Effect of Mg-Nb oxides addition on hydrogen sorption in MgH{sub 2}

    Rahman, M.W.; Castellero, A. [Dipartimento di Chimica IFM, NIS Centre of Excellence, Universita di Torino, Via Pietro Giuria 9, 10125 Torino (Italy); Enzo, S. [Dipartimento di Chimica, Universita di Sassari, 07100 Sassari (Italy); Livraghi, S.; Giamello, E. [Dipartimento di Chimica IFM, NIS Centre of Excellence, Universita di Torino, Via Pietro Giuria 9, 10125 Torino (Italy); Baricco, M., E-mail: [Dipartimento di Chimica IFM, NIS Centre of Excellence, Universita di Torino, Via Pietro Giuria 9, 10125 Torino (Italy)


    Highlights: > H{sub 2} sorption reactions in MgH{sub 2} with 1 mol% MgNb{sub 2}O{sub 6}, Mg{sub 4}Nb{sub 2}O{sub 9} and Mg{sub 3}Nb{sub 6}O{sub 11} have been investigated. > Ball-milled samples showed the presence of a mixture of {beta} and {gamma} allotropes of MgH{sub 2}. > The presence of Mg-Nb oxides significantly accelerates the hydrogen absorption and desorption processes. > Experimental results are discussed on the basis of thermodynamic and kinetic arguments. - Abstract: H{sub 2} absorption and desorption reactions in MgH{sub 2} promoted by ball-milling with 1 mol% MgNb{sub 2}O{sub 6}, Mg{sub 4}Nb{sub 2}O{sub 9} and Mg{sub 3}Nb{sub 6}O{sub 11} have been investigated. MgH{sub 2} was milled with the bare oxides for 12 h under a high purity Ar atmosphere. Absorption and desorption reactions in the ball-milled samples were studied by in situ X-ray diffraction (XRD) in isothermal conditions with Anton Paar XRK 900 reaction chamber. XRD patterns for absorption were recorded at 573 K under hydrogen pressure of 0.9 MPa and for desorption at 623 K in vacuum. Experimental data were analysed according to the Rietveld method. Ball-milled samples showed the presence of a mixture of {beta} and {gamma} allotropes of MgH{sub 2}, with significantly broadened diffraction peaks due to reduced crystallite size and strain, together with bare additives. The presence of Mg-Nb oxides significantly accelerates the hydrogen absorption and desorption processes. The amount of hydrogen absorbed in the presence of Mg-Nb-O phases is lower than the maximum stoichiometric capacity, because of the presence of a non-reactive MgO layer on the surface of the powders or at the grain boundaries. Experimental results are discussed on the basis of thermodynamic and kinetic arguments.

  19. Preparation of an additive-free sample with a MgH2 phase by planetary ball milling of Mg with10 wt% MgH2

    Hong, Seong-Hyeon; Song, Myoung Youp


    In order to prepare an additive-free sample with a MgH2 phase, 90 wt% Mg+10 wt% MgH2 (named Mg-10MgH2) was milled under hydrogen atmosphere in a planetary ball mill for different durations (2 h, 5 h, and 10 h). The hydrogen absorption and release properties of the prepared samples were investigated and compared with those of purchased pure MgH2 samples. Mg-10MgH2 milled for 5 h had the largest quantity of hydrogen released at 648 K for 100 min of 5.96 wt%. Mg-10MgH2 milled for 5 h released 0.11 wt% H for 10 min, 4.85 wt% H for 30 min, and 5.83 wt% H for 60 min at 648 K at the first cycle. Mg-10MgH2 milled for 5 h absorbed 5.39 wt% H for 5 min and 5.92 wt% H for 60 min at 648 K at the second cycle. Dehydriding curves were also obtained at the first cycle of Mg-10MgH2 samples milled for 5 h using Mg powder with or without sieving (200 mesh). The dehydriding curve at 648 K of a Mg-10MgH2 sample milled for 5 h in the planetary ball mill was compared with that of the sample milled for 24 h in a horizontal ball mill.

  20. Destabilization of Mg Hydride by Self-Organized Nanoclusters in the Immiscible Mg-Ti System

    Asano, Kohta; Westerwaal, Ruud J.; Anastasopol, Anca; Mooij, Lennard P A; Boelsma, Christiaan; Ngene, Peter; Schreuders, Herman; Eijt, Stephan W H; Dam, Bernard


    Mg is an attractive hydrogen storage material not only because of its high gravimetric and volumetric hydrogen capacities but also because of it low material costs. However, the hydride of MgH2 is too stable to release hydrogen under moderate conditions. We demonstrate that the formation of

  1. Energy Bands and Fermi Surface for beta-MgMh and beta-MgTl

    Skriver, Hans Lomholt


    The energy bands of ordered β′-MgHg and β′-MgTl have been calculated by the relativistic linear-muffintin-orbital method. We show how the gross features of the energy bands may be estimated from Wigner-Seitz rules. The densities of states are calculated and the heat capacities derived. The Fermi...

  2. Destabilization of Mg Hydride by Self-Organized Nanoclusters in the Immiscible Mg-Ti System

    Asano, Kohta; Westerwaal, Ruud J.; Anastasopol, Anca; Mooij, Lennard P A; Boelsma, Christiaan; Ngene, Peter; Schreuders, Herman; Eijt, Stephan W H; Dam, Bernard


    Mg is an attractive hydrogen storage material not only because of its high gravimetric and volumetric hydrogen capacities but also because of it low material costs. However, the hydride of MgH2 is too stable to release hydrogen under moderate conditions. We demonstrate that the formation of nanomete

  3. Universal Unitarity Triangle 2016 and the tension between ΔM{sub s,d} and ε{sub K} in CMFV models

    Blanke, Monika [Karlsruhe Institute of Technology, Institut fur Kernphysik, Eggenstein-Leopoldshafen (Germany); Karlsruhe Institute of Technology, Institut fur Theoretische Teilchenphysik, Karlsruhe (Germany); Buras, Andrzej J. [TUM-IAS, Garching (Germany); TUM, Physik Department, Garching (Germany)


    Motivated by the recently improved results from the Fermilab Lattice and MILC Collaborations on the hadronic matrix elements entering ΔM{sub s,d} in B{sup 0}{sub s,d}- anti B{sup 0}{sub s,d} mixing, we determine the universal unitarity triangle (UUT) in models with constrained minimal flavour violation (CMFV). Of particular importance are the very precise determinations of the ratio vertical stroke V{sub ub} vertical stroke / vertical stroke V{sub cb} vertical stroke = 0.0864 ± 0.0025 and of the angle γ = (62.7 ± 2.1) {sup circle}. They follow in this framework from the experimental values of ΔM{sub d}/ΔM{sub s} and of the CP-asymmetry S{sub ψK{sub S}}. As in CMFV models the new contributions to meson mixings can be described by a single flavour-universal variable S(v), we next determine the CKM matrix elements vertical stroke V{sub ts} vertical stroke, vertical stroke V{sub td} vertical stroke, vertical stroke V{sub cb} vertical stroke and vertical stroke V{sub ub} vertical stroke as functions of S(v) using the experimental value of ΔM{sub s} as input. The lower bound on S(v) in these models, derived by us in 2006, implies then upper bounds on these four CKM elements and on the CP-violating parameter ε{sub K}, which turns out to be significantly below its experimental value. This strategy avoids the use of tree-level determinations of vertical stroke V{sub ub} vertical stroke and vertical stroke V{sub cb} vertical stroke, which are presently subject to considerable uncertainties. On the other hand, if ε{sub K} is used instead of ΔM{sub s} as input, ΔM{sub s,d} are found to be significantly above the data. In this manner we point out that the new lattice data have significantly sharpened the tension between ΔM{sub s,d} and ε{sub K} within the CMFV framework. This implies the presence of new physics contributions beyond this framework that are responsible for the breakdown of the flavour universality of the function S(v). We also present the

  4. Demonstration of Mg2FeH6 as heat storage material at temperatures up to 550 °C

    Urbanczyk, R.; Meggouh, M.; Moury, R.; Peinecke, K.; Peil, S.; Felderhoff, M.


    The storage of heat at high temperatures, which can be used to generate electricity after sunset in concentrating solar power plants, is one of the most challenging technologies. The use of metal hydride could be one possibility to solve the problem. During the endothermic heat storage process, the metal hydride is decomposed releasing hydrogen, which then can be stored. During the exothermic reaction of the metal with the hydrogen gas, the stored heat is then released. Previous research had shown that Mg and Fe powders can be used at temperatures up to 550 °C for heat storage and shows excellent cycle stability over hundreds of cycles without any degradation. Here, we describe the results of testing of a tube storage tank that contained 211 g of Mg and Fe powders in 2:1 ratio. Twenty-three dehydrogenations (storage) and 23 hydrogenations (heat release) in the temperature range between of 395 and 515 °C and pressure range between 1.5 and 8.6 MPa were done. During the dehydrogenation, 0.41-0.42 kWhth kg-1 of heat based on material 2 Mg/Fe can be stored in the tank. After testing, mainly Mg2FeH6 was observed and small amounts of MgH2 and Fe metal can be detected in the hydride samples. This means that the heat storage capacity of the system could be further increased if only Mg2FeH6 is produced during subsequent cycles.

  5. Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty

    McQuay, H. J.; Moore, R. A.; Berta, A.; Gainutdinovs, O.; Fülesdi, B.; Porvaneckas, N.; Petronis, S.; Mitkovic, M.; Bucsi, L.; Samson, L.; Zegunis, V.; Ankin, M. L.; Bertolotti, M.; Pizà-Vallespir, B.; Cuadripani, S.; Contini, M. P.; Nizzardo, A.


    Background. The aim was to evaluate the analgesic efficacy and safety of the dexketoprofen/tramadol 25 mg/75 mg fixed-dose combination vs dexketoprofen (25 mg) and tramadol (100 mg) in moderate-to-severe acute pain after total hip arthroplasty. Methods. This was a randomized, double-blind, parallel-group study in patients experiencing pain of at least moderate intensity on the day after surgery, compared with placebo at first administration to validate the pain model. The study drug was administered orally every 8 h throughout a 5 day period. Rescue medication, metamizole 500 mg, was available during the treatment period. The evaluation of efficacy was based on patient assessments of pain intensity and pain relief. The primary end point was the mean sum of the pain intensity difference values throughout the first 8 h (SPID8). Results. Overall, 641 patients, mean age 62 (range 29–80) yr, were analysed; mean (sd) values of SPID8 were 247 (157) for dexketoprofen/tramadol, 209 (155) for dexketoprofen, 205 (146) for tramadol, and 151 (159) for placebo. The primary analysis confirmed the superiority of the combination over dexketoprofen 25 mg (P=0.019; 95% confidence interval 6.4–73) and tramadol 100 mg (P=0.012; 95% confidence interval 9.5–76). The single components were superior to placebo (P<0.05), confirming model sensitivity. Most secondary analyses supported the superiority of the combination. The incidence of adverse drug reactions was low and similar among active treatment groups. Conclusion. The efficacy results confirmed the superiority of dexketoprofen/tramadol over its single components, even at higher doses (tramadol), with a safety profile fully in line with that previously known for these agents in monotherapy. Clinical trial registration. EudraCT 2012-004548-31 (; NCT01902134 (

  6. Modification effect of lanthanum on primary phase Mg2Si in Mg-Si alloys

    WANG Liping; GUO Erjun; MA Baoxia


    The modifying effect of La addition on primary phase Mg2Si in Mg-5Si alloys was investigated. The results showed that a proper amount of La could effectively modify the primary phase Mg2Si. Based on the present experiment, the optimal modification effect was obtained with an addition of about 0.5 wt.% La. The size of the primary phase Mg2Si was considerably reduced to 25 μm or less and the morphology was modified from a coarse dendritic shape to a polyhedral shape. However, when the addition of La increased to 0.8 wt.% or higher, the primary Mg2Si grew into a coarse dendritic morphology again. Moreover, it was found that some LaSi2 compounds were formed during solidification and the amount of the compounds appeared to increase gradually with increasing La content.

  7. Microstructure and hardness of Mg-based composites reinforced with Mg2Si particles

    Mustafa Aydin; Cem Ozgür; Osman San


    Magnesium powders were mechanically alloyed with SiO2 powder particles having different particle sizes using high-energy ball milling techniques under Ar atmosphere for 1 h. The powders were consolidated with cold pressing under 560 Mpa. They were then sintered at 550℃ for 45 min under Ar atmosphere. The composites obtained on the Mg-SiO2 system were investigated using the Archimedes principle, a differential scanning calorimeter, X-ray diffraction, optic microscopy, and scanning electron microscopy. For the mechanically alloyed powders, the solid-state reaction of the synthesis of Mg2Si and MgO progressed further during sintering of the materials. The results showed that the strengthening mechanisms were dependent on dispersion hardening of fine Mg2Si and MgO particulates dispersed homogeneously in the matrix.

  8. Growth of MgO on multi-layered graphene and Mg in PVA matrix

    Marka, Sandeep K.; Mohiddon, Md. Ahamad; Prasad, Muvva D.; Srikanth, Vadali V. S. S.


    An easy and low temperature in-situ growth of MgO micro-rods on multi-layered graphene (MLG) in poly vinyl alcohol (PVA) matrix is elucidated. MLG decked with nanosized fragments of MgO and PVA are used as the starting materials to form MgO micro-rods (width = ∼1 μm and length = ∼4 μm) and MLG filled PVA composite film. Simple solution mixing, spin coating and simple drying processes are used to obtain the PVA composite. The growth mechanism of MgO micro-rods and the role of PVA in the growth of MgO micro-rods are explained on the basis of the observed morphological, structural and phase characteristics and a further controlled synthesis experiment, respectively.

  9. Mg based alloys obtained by mechanical alloying

    Ordonez, S. [Univ. de Santiago de Chile (Chile). Fac. de Ingenieria; Garcia, G.; Serafini, D.; San Martin, A.


    In the present work, we studied the production of magnesium alloys, of stoichiometry 2Mg + Ni, by mechanical alloying (MA) and the behavior of the alloys under hydrogen in a Sievert`s type apparatus. The elemental powders were milled under argon atmosphere in a Spex 8000 high energy ball mill. The milled materials were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Only minimum amounts of the Mg{sub 2}Ni intermetallic compound was obtained after 22 h of milling time. Most of the material was sticked to the inner surface of the container as well as to the milling balls. Powders milled only for 12 hours transforms to the intermetallic at around 433 K. Effects of the MA on the hydrogen absorption kinetics were also studied. (orig.) 10 refs.

  10. Bulk amorphous Mg-based alloys

    Pryds, Nini


    The present paper describes the preparation and properties of bulk amorphous quarternary Mg-based alloys and the influence of additional elements on the ability of the alloy to form bulk amorphous. The main goal is to find a Mg-based alloy system which shows both high strength to weight ratio...... and a low glass transition temperature. The alloys were prepared by using a relatively simple technique, i.e. rapid cooling of the melt in a copper wedge mould. The essential structural changes that are achieved by going from the amorphous to the crystalline state through the supercooled liquid state...... are discussed in this paper. On the basis of these measurements phase diagrams of the different systems were constructed. Finally, it is demonstrated that when pressing the bulk amorphous alloy onto a metallic dies at temperatures within the supercooled liquid region, the alloy faithfully replicates the surface...

  11. Novel alginate based coatings on Mg alloys

    Sangeetha, K.; Roy, Abhijit [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Singh, Satish [Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Lee, Boeun [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Kumta, Prashant N., E-mail: [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261 (United States)


    Coatings on yttrium doped magnesium (Mg4Y) alloy substrates were prepared using alginate hydrogels by dip coating method to improve the surface bioactive properties of the substrate. Furthermore, composite coatings containing nano-sized calcium phosphate corresponding to hydroxyapatite (HA) phase entrapped within alginate hydrogel were also synthesized on the Mg4Y substrates. Surface characteristics of these coated substrates have been investigated using FTIR-ATR, SEM and EDS. The results show that the coatings with alginate alone are not stable in vitro; however, incorporation of NanoCaPs slightly improves the stability of these coatings. In addition, these composite coatings showed cell attachments with fibronectin incorporation. These results indicate that alginate hydrogels have the potential to be used as bioactive coating materials for different biofunctional applications.

  12. Study of the sodium hyaluronate toxicity on SD rats in sensitive period of teratogenesis%透明质酸钠对SD大鼠致畸敏感期的毒性试验

    彭亮; 傅伟忠; 王彦武; 覃辉艳; 姚思宇; 梁慧莉; 何励


    OBJECTIVE: To explore the toxicity of sodium hyaluronate on SD rate in sensitive period of teratogenesis. METHODS: Pregnant rats were divided randomly into five groups, three sodium hyaluronate groups (1 333, 667 and 333 mg/kg), one negative control given deionized water, and one positive control given Aspirin (250 mg/kg>. There were at least 12 pregnant rats in each group. During the sensitive period of laratogenesis (the 7th to 16th day of gestation), the pregnant rats of each group were given test sample orally once a day for ten days. On the 20th day of gestation, the pregnant rals were sacrificed. Emhryonic and fetal development were evaluated, appearance, viscesal and skeletal abnormalities were observed. RESULTS: In sodium hyaluronate groups, (he weight of pregnant rats and uterus including fetuses, living fetus rate, dead fetua rale, body weight, length of body and tail of fetuses were not significantly different from negative control. No abnormality of skeleton, organ and body was identified in fetuses of groups treated with sodium hyaluronaie. CONCLUSION: At dosages used in this study, sodium hyaluronate had neilher maternal tosiciry nor teratogenecity in pregnant SD rats.%目的:探讨透明质酸钠对SD大鼠致畸敏感期的毒性.方法:将妊娠期SD大鼠随机分为5个组,分别为3个透明质酸钠不同剂量试验组(1333、667和333 mg/kg)、阴性对照组(去离子水)和阳性对照组(250 mg/kg阿司匹林),每组不少于12只.在大鼠致畸敏感期(妊娠第7~16天),连续经口灌胃给予受试物10d,每天1次.妊娠第20天处死孕鼠,取出胎鼠,检测胚胎和胎仔发育指标,并检查外观、内脏和骨骼有无畸形.结果:透明质酸钠各剂量组孕鼠体质量、子官连胎质量、活胎率、死胎率,胎鼠体质量、身长和尾长与阴性对照组相比较,差异均无统计学意义(P>0.05),也未见外观、内脏和骨骼畸形.结论:透明质酸钠在本试验剂量下,对SD大鼠无母体毒性和致畸毒性.

  13. Electronic structure of MgB2

    P Modak; R S Rao; B K Godwal; S K Sikka


    Results of ab initio electronic structure calculations on the compound MgB2 using the FPLAPW method employing GGA for the exchange-correlation energy are presented. Total energy minimization enables us to estimate the equilibrium volume, / ratio and the bulk modulus, all of which are in excellent agreement with experiment. We obtain the mass enhancement parameter by using our calculated (F) and the experimental specific heat data. The c is found to be 24.7 K.

  14. Orientation relationships between icosahedral clusters in hexagonal MgZn2 and monoclinic Mg4Zn7 phases in Mg-Zn(-Y) alloys

    Rosalie, Julian M.; Somekawa, Hidetoshi; Singh, Alok; Mukai, Toshiji


    Intermetallic precipitates formed in heat-treated and aged Mg-Zn and Mg-Zn-Y alloys have been investigated via electron microscopy. Coarse spheroidal precipitates formed on deformation twin boundaries contained domains belonging to either the MgZn2 hexagonal Laves phase or the monoclinic Mg4Zn7 phase. Both phases are structurally related to the quasi-crystalline phase formed in Mg-Zn-Y alloys, containing icosahedrally coordinated zinc atoms arranged as a series of broad rhombohedral units. This rhombohedral arrangement was also visible in intragranular precipitates where local regions with the structures of hexagonal MgZn2 and Mg4Zn7 were found. The orientation adopted by the MgZn2 and Mg4Zn7 phases in twin-boundary and intragranular precipitates was such that the icosahedral clusters were aligned similarly. These results highlight the close structural similarities between the precipitates of the Mg-Zn-Y alloy system.

  15. Interstitial Fe in MgO

    Mølholt, T E; Gunnlaugsson, H P; Svane, A; Masenda, H; Naidoo, D; Bharuth-Ram, K; Fanciulli, M; Gislason, H P; Johnston, K; Langouche, G; Ólafsson, S; Sielemann, R; Weyer, G


    Isolated Fe-57 atoms were studied in MgO single-crystals by emission Mossbauer spectroscopy following implantation of Mn-57 decaying to Fe-57. Four Mossbauer spectral components were found corresponding to different Fe lattice positions and/or charge states. Two components represent Fe atoms substituting Mg as Fe2+ and Fe3+, respectively; a third component is due to Fe in a strongly implantation-induced disturbed region. The fourth component, which is the focus of this paper, can be assigned to Fe at an interstitial site. Comparison of its measured isomer shift with ab initio calculations suggests that the interstitial Fe is located on, or close to, the face of the rock-salt MgO structure. To harmonize such an assignment with the measured near-zero quadrupole interaction a local motion process (cage motion) of the Fe has to be stipulated. The relation of such a local motion as a starting point for long range diffusion is discussed.

  16. The study on increasing the equivalent SNR in the certain DOI by adjusting the SD separation in near-infrared brain imaging application

    Wang, Jinhai; Liu, Dongyuan; Sun, Jinggong; Zhang, Yanjun; Sun, Qiuming; Ma, Jun; Zheng, Yu; Wang, Huiquan


    Near-infrared (NIR) brain imaging is one of the most promising techniques for brain research in recent years. As a significant supplement to the clinical imaging technique, such as CT and MRI, the NIR technique can achieve a fast, non-invasive, and low cost imaging of the brain, which is widely used for the brain functional imaging and hematoma detection. NIR imaging can achieve an imaging depth up to only several centimeters due to the reduced optical attenuation. The structure of the human brain is so particularly complex, from the perspective of optical detection, the measurement light needs go through the skin, skull, cerebrospinal fluid (CSF), grey matter, and white matter, and then reverses the order reflected by the detector. The more photons from the Depth of Interest (DOI) in brain the detector capture, the better detection accuracy and stability can be obtained. In this study, the Equivalent Signal to Noise Ratio (ESNR) was defined as the proportion of the photons from the DOI to the total photons the detector evaluated the best Source and Detector (SD) separation. The Monte-Carlo (MC) simulation was used to establish a multi brain layer model to analyze the distribution of the ESNR along the radial direction for different DOIs and several basic brain optical and structure parameters. A map between the best detection SD separation, in which distance the ESNR was the highest, and the brain parameters was established for choosing the best detection point in the NIR brain imaging application. The results showed that the ESNR was very sensitivity to the SD separation. So choosing the best SD separation based on the ESNR is very significant for NIR brain imaging application. It provides an important reference and new thinking for the brain imaging in the near infrared.

  17. Hubungan Faktor Higieni Pribadi, Karakteristik Individu, dan Status Sosial Ekonomi Keluarga dengan Kejadian Pediculosis Capitis pada Siswa SD Negeri No.095226 Hasurungan, Kec.Raya Kahean, Kab. Simalungun

    Damanik, Erlina Theovani


    Pediculosis capitis or head lice infestation that caused by Pediculus humanus capitis is a common health problem in community. Pediculosis capitis occurs most commonly in children, with a peak inciden between 5 and 13 years of age. The aim of this study is to determine the relation of personal higieny, individual characteristic and socio-economic status with the incidence of Pediculosis capitis among students in SD Negeri No.095226 Hasurungan, Kec.Raya Kahean, Kab.Simalungun...

  18. Design of SD Memory Card Interface Based on Nios II Softcore%基于Nios II软核处理器的SD卡接口设计



    随着FPGA的低成本化和整合资源的不断增强,FPGA在整个嵌入式市场中的份额在不断增加。基于FPGA的NiosII软核以其高度的设计灵活性和完全可定制性在现今电子产品设计及工业控制中扮演着重要的角色。此外,以SD卡为代表的大容量存储卡成为消费电子类产品最重要的存储媒体。基于NiosII软核处理器来读写SD卡的接口设计在诸多电子系统中的使用也愈来愈多。文中给出了基于NiosII软核处理器的SD卡接口设计方案,并介绍了NiosII的驱动架构,给出SD存储卡在NiosII软核上的驱动程序设计。%With low-cost FPGA and its growing integration of resources,the share of FPGA in the entire embedded market continues to increase. FPGA-based Nios II soft core for its high degree of design flexibility and full customizability plays an important role in today's electronic products and industrial control design. In addition,the SD mass storage card becomes the most important media in consumer electronics products. SD card reader interface design based on the Nios II soft core processor is more and more used in many electronic systems. In this paper,proposed the Nios II soft core processor based SD card interface design and Nios II driver architecture. In addition, presented the design of the SD memory card driver based on Nios II soft core.

  19. Hubungan Infeksi Cacing Ascaris Lumbricoides Dengan Indeks Massa Tubuh Pada Siswa Perempuan SD Salsabila Kecamatan Medan Marelan Kota Medan Tahun 2014

    Simbolon, Christiani


    Cacing gelang (Ascaris lumbricoides) merupakan salah satu penyebab infeksi dengan prevalensi mencapai 60-90% di Indonesia. Cacing ini dapat mengambil sumber karbohidrat dan protein di usus sebelum diserap tubuh. Infeksi cacing banyak diderita anak sekolah dasar, yaitu sekitar 40-60%. Metode yang digunakan untuk penelitian ini adalah observasional analitik dengan studi cross-sectional. Sampel diambil dengan metode consecutive sampling pada siswa perempuan kelas I sampai kelas VI SD Salsabil...

  20. Comparison of hydrogen storage properties of pure Mg and milled pure Mg

    Myoung Youp Song; Young Jun Kwak; Seong Ho Lee; Hye Ryoung Park


    Hydrogen storage properties of pure Mg were studied at 593 K under 12 bar H2. In order to increase the hydriding and dehydriding rates, pure Mg was ground under hydrogen atmosphere (reactive mechanical grinding, RMG) and its hydrogen storage properties were subsequently investigated. Pure Mg absorbed hydrogen very slowly. At the number of cycles () of 1, pure Mg absorbed 0.05 wt% H for 5 min, 0.08 wt% H for 10 min and 0.29 wt% H for 60 min at 593 K under 12 bar H2. Activation was completed at the fifth cycle. At = 6, pure Mg absorbed 1.76 wt% H for 5 min, 2.17 wt% H for 10 min and 3.40 wt% H for 60 min. The activation of pure Mg after RMG was completed at the sixth cycle. At = 7, pure Mg after RMG absorbed 2.57 wt% H for 5 min, 3.21 wt% H for 10 min and 4.15 wt% H for 60 min.

  1. Midazolam 12 mg is moderately counteracted by 250 mg caffeine in man.

    Mattila, M J; Vainio, P; Nurminen, M L; Vanakoski, J; Seppälä, T


    Caffeine (Caf) counteracts various effects of benzodiazepines (BZDs). Since the effects of zolpidem, a short-acting atypical GABA(A)-BZD agonist, were not antagonized by Caf, we studied an interaction between Caf and midazolam (Mid) in healthy volunteers. In Study 1, 108 healthy students divided to 6 parallel groups were given Mid 12 mg (capsule) and Caf 125 and 250 mg (in decaffeinated coffee), alone and in combinations in the double-blind placebo-controlled manner. Objective and subjective tests were done before and at 45 and 90 min after intake. Ranked delta-values (changes from baseline) were analyzed by one-way contrast ANOVA and Scheffe's tests. In Study 2, six healthy subjects took Mid 15 mg (tablet) with and without Caf 300 mg. The dynamic effects were analyzed as in Study 1 and the plasma concentrations were assayed. In Study 1, learn effects after placebo (ad + 15%) were seen for letter cancellation and digit symbol substitution tests. Midazolam alone significantly (p 0.05). In conclusion, in a parallel group study, sedative effects of Mid 12 mg were only moderately antagonized by Caf 250 mg but not by Caf 125 mg. In a cross-over study, a weak interaction was found subjectively but not in objective measures.

  2. Zolpidem 10 mg given at daytime is not antagonized by 300 mg caffeine in man.

    Mattila, M J; Nurminen, M L; Vainio, P; Vanakoski, J


    Caffeine counteracts various effects of traditional benzodiazepines (BZDs). As zolpidem, a short-acting hypnotic, is an atypical GABAA-BZD agonist, we investigated when caffeine would counteract the effects of zolpidem as well. In daytime study I, zolpidem 10 mg (capsule) and caffeine 150 or 300 mg (in decaffeinated coffee) were given, alone and in combinations, to parallel groups (n = 15-17) of healthy students in double-blind and placebo-controlled manner. Objective and subjective tests were done before and 45 min and 90 min after intake. Ranked delta values (changes from baseline) were analysed by one-way contrast ANOVA and Scheffe's tests. In daytime study II, four healthy subjects took zolpidem 10 mg alone, and together with blinded caffeine 250 mg or (at -45 min) erythromycin 750 mg. Objective and subjective effects were measured and plasma zolpidem concentrations assayed at baseline and 45 min and 90 min after zolpidem intake. In study I, practice effects after placebo (ad + 30%) were seen for letter cancellation and digit symbol substitution but not for flicker fusion tests. Zolpidem alone significantly impaired (P effects of zolpidem and either dose of caffeine matched those measured after zolpidem alone. Zolpidem + caffeine 300 mg was not stronger than zolpidem + caffeine 150 mg in impairing immediate memory and causing subjective sedation. In study II, zolpidem caused objective and subjective sedation; neither caffeine nor erythromycin modulated the effects of zolpidem or plasma zolpidem concentrations. The sedative effects of 10 mg of zolpidem are not antagonized by 150-300 mg of caffeine in pharmacodynamic or pharmacokinetic terms.

  3. Electronic structure of ferromagnet-insulator interfaces: Fe/MgO and Co/MgO

    Mueller, M.


    In this thesis the electronic structure of Fe/MgO{sub x} and Co/MgO{sub x} ferromagnet-insulator interfaces, representing material systems which are widely used in magnetic tunnel junctions, is studied by means of spin- and angle-resolved photoemission spectroscopy. The photoemission studies focus particularly on the response of the ferromagnetic electronic system in contact with MgO of varying stoichiometries, as this reflects the mechanisms of metal-oxide bonding at real ferromagnet-insulator interfaces. The correlation between chemical bonding and electronic structure formation is analyzed by combining information from core- and valence-band photoemission spectroscopy. The spectral features are compared to band structure calculations, which are performed using the SPR-KKR method. The Fe/MgO and Co/MgO systems are prepared by molecular beam epitaxy under ultrahigh vacuum conditions on well-defined (4 x 6) GaAs(001) substrates. A structural analysis by means of low-energy electron diffraction (LEED) reveals their body-centered cubic crystalline structure, whereas the chemical characterization by Auger electron spectroscopy is used to quantify the chemical environment at the sample surfaces. The magnetic analysis, using the magneto-optical Kerr effect, reveals the uniaxial anisotropy of the ferromagnetic layers. A crucial parameter is given by the MgO degree of oxidation, which is addressed by means of core-level spectroscopy and quantified by suitable fitting procedures of the Mg 2p core level. The results of the photoemission experiments show, that the electronic structure of the Fe/MgO and Co/MgO ferromagnet/insulator interfaces and, consequently, the interfacial spin polarization are sensitively controlled by the interface chemistry. In particular, three distinct scenarios are identified: the nearly stoichiometric, the oxygen-deficient and the over-oxidized ferromagnet/MgO interface. Each case is defined by innate characteristics of the electronic structure at

  4. FeII/MgII, [Fe/Mg] Ratios and High-z Quasars

    Korista, K; Corbin, M R; Freudling, W; Korista, Kirk; Kodituwakku, Nalaka; Corbin, Michael; Freudling, Wolfram


    It has been suggested in the literature that the (Fe/alpha) abundance ratio may be used as a chronometer, due to a delay in this ratio reaching its solar value as predicted by galactic chemical evolution models. Using grids of photoionization models along a sequence of the (Fe/Mg) abundance ratio vs.\\ metallicity with time in a giant elliptical starburst scenario, we investigate the relationship between the (Fe/Mg) abundance ratio and the FeII/MgII emission line flux ratio under the assumption that these lines originate in photoionized clouds within the broad emission line regions of quasars.

  5. Lipid peroxidation in the liver of rats treated with V and/or Mg in drinking water.

    Scibior, Agnieszka; Zaporowska, Halina; Niedźwiecka, Irmina


    revealed that the changes in LPO induced by in vitro treatment of liver supernatants with exogenous Fe or V or Mg (600, 800 and 1000 microm) were a consequence of independent action of those metals and they also resulted from the interactions between Fe(exog) and V(end) and between V(end) and V(exog). In conclusion, V consumed by the rats with drinking water at a dose of 12 mg V kg(-1) body weight per 24 h for 12 weeks decreased TAS and enhanced spontaneous LPO in the hepatic tissue, which confirms its pro-oxidant potential, was also found in in vitro conditions with regard to LPO. Mg administered to rats in combination with V, at the concentration used, neither reduced nor intensified the basal LPO, compared with V-only treated animals; however, its stimulating effect on LPO was revealed in in vitro conditions, which requires further study.

  6. Cell death triggering and effector recognition by Sw-5 SD-CNL proteins from resistant and susceptible tomato isolines to Tomato spotted wilt virus.

    De Oliveira, Athos Silva; Koolhaas, Ivo; Boiteux, Leonardo Silva; Caldararu, Octav F; Petrescu, Andrei-Jose; Oliveira Resende, Renato; Kormelink, Richard


    Only a limited number of dominant resistance genes acting against plant viruses have been cloned, and further functional studies of these have been almost entirely limited to the resistance genes Rx against Potato virus X (PVX) and N against Tobacco mosaic virus (TMV). Recently, the cell-to-cell movement protein (NSM ) of Tomato spotted wilt virus (TSWV) has been identified as the avirulence determinant (Avr) of Sw-5b-mediated resistance, a dominant resistance gene which belongs to the class of SD-CC-NB-LRR (Solanaceae domain-coiled coil-nucleotide-binding-leucine-rich repeat, SD-CNL) resistance genes. On transient expression of the NSM protein in tomato and transgenic Nicotiana benthamiana harbouring the Sw-5b gene, a hypersensitive cell death response (HR) is triggered. Here, it is shown that high accumulation of the Sw-5b protein in N. benthamiana leaves, achieved by co-expression of the Sw-5b protein with RNA silencing suppressors (RSSs), leads to auto-activity in the absence of NSM . In a similar approach, Sw-5a, the highest conserved paralogue of Sw-5b from Solanum peruvianum, also triggered HR by auto-activation, whereas the highest conserved orthologue from susceptible S. lycopersicum, named Sw-5a(S) , did not. However, neither of the last two homologues was able to trigger an NSM -dependent HR. Truncated and mutated versions of these Sw-5 proteins revealed that the NB-ARC [nucleotide-binding adaptor shared by Apaf-1 (from humans), R proteins and CED-4 (from nematodes)] domain is sufficient for the triggering of HR and seems to be suppressed by the SD-CC domain. Furthermore, a single mutation was sufficient to restore auto-activity within the NB-ARC domain of Sw-5a(S) . When the latter domain was fused to the Sw-5b LRR domain, NSM -dependent HR triggering was regained, but not in the presence of its own Sw-5a(S) LRR domain. Expression analysis in planta revealed a nucleocytoplasmic localization pattern of Sw-5b, in which the SD-CC domain seems to be

  7. A first-principles study of the thermodynamic and electronic properties of Mg and MgH2 nanowires.

    Wu, Xinxing; Zhang, Ruiqi; Yang, Jinlong


    In this article, we studied the thermodynamic and electronic properties of Mg and MgH2 nanowires with different diameters, and elucidated why MgH2 nanowires are good hydrogen storage materials through first-principles calculations. Previous experiments have shown that the orientation relationship between Mg and MgH2 nanowires is the Mg[0001] direction parallel to the MgH2[110] direction. In our calculations, Mg nanowires oriented along the [0001] direction and MgH2 nanowires oriented along the [110] direction were built from bulk Mg and MgH2 crystals, respectively. We found that as the diameters of Mg and MgH2 nanowires decrease, Mg and MgH2 nanowires become more unstable, and the hydrogen desorption energies and temperatures of MgH2 nanowires decrease. That is, the thinner the MgH2 nanowires get, the more dramatically hydrogen desorption temperatures (Td) will decrease. Meanwhile, we also found that when the diameters of MgH2 nanowires are larger than 1.94 nm, the Td almost maintain the same value at about 440 K, only about 40 K lower than that of bulk MgH2 crystal; if the diameters are less than 1.94 nm, the Td reduce very quickly. In particular, compared with bulk MgH2 crystal, the Td of the thinnest MgH2 nanowire with a diameter of 0.63 nm can be reduced by 164 K. In addition, the electronic structure calculations showed that Mg nanowires are metals, while MgH2 nanowires are semiconductors. In particular, our results showed that the electronic structures of MgH2 nanowires are influenced by the surface effect and quantum size effect. That is to say, the band gaps of MgH2 nanowires are controlled by surface electronic states and the size of MgH2 nanowires.

  8. Microstructural evolution of Mg-7Al-2Sn Mg alloy during multi-directional impact forging

    M.G. Jiang


    Full Text Available Multi-directional impact forging (MDIF was applied to a Mg-7Al-2Sn (wt.% Mg alloy to investigate its effect on the microstructural evolution. MDIF process exhibited high grain refinement efficiency. After MDIF 200 passes, the grain size drastically decreased to 20 µm from the initial coarse grains of ~500 µm due to dynamic recrystallization (DRX. Meanwhile, original grain boundaries remained during MDIF and large numbers of fine spherical β-Mg17Al12 particles dynamically precipitated along the original grain boundaries with high Al concentration, acting as effective pinning obstacles for the suppression of DRXed grain growth. Besides, micro-cracks nucleated during MDIF and propagated along the interface between the remained globular or cubic Al-Mn particles and Mg matrix.

  9. Proton resonance elastic scattering of $^{30}$Mg for single particle structure of $^{31}$Mg

    The single particle structure of $^{31}$Mg, which is located in the so-called “island of inversion”, will be studied through measuring Isobaric Analog Resonances (IARs) of bound states of $^{31}$Mg. They are located in the high excitation energy of $^{31}$Al. We are going to determine the spectroscopic factors and angular momenta of the parent states by measuring the excitation function of the proton resonance elastic scattering around 0 degrees in the laboratory frame with around 3 MeV/nucleon $^{30}$Mg beam. The present study will reveal the shell evolution around $^{32}$Mg. In addition, the spectroscopic factor of the (7/2)$^{−}$ state which was not yet determined experimentally, may allow one to study the shape coexistence in this nucleus.

  10. Thermodynamic Property Study of Nanostructured Mg-H, Mg-Ni-H, and Mg-Cu-H Systems by High Pressure DSC Method

    Huaiyu Shao


    Full Text Available Mg, Ni, and Cu nanoparticles were synthesized by hydrogen plasma metal reaction method. Preparation of Mg2Ni and Mg2Cu alloys from these Mg, Ni, and Cu nanoparticles has been successfully achieved in convenient conditions. High pressure differential scanning calorimetry (DSC technique in hydrogen atmosphere was applied to study the synthesis and thermodynamic properties of the hydrogen absorption/desorption processes of nanostructured Mg-H, Mg-Ni-H, and Mg-Cu-H systems. Van’t Hoff equation of Mg-Ni-H system as well as formation enthalpy and entropy of Mg2NiH4 was obtained by high pressure DSC method. The results agree with the ones by pressure-composition isotherm (PCT methods in our previous work and the ones in literature.

  11. Magnesium homeostasis in cardiac myocytes of Mg-deficient rats.

    Michiko Tashiro

    Full Text Available To study possible modulation of Mg(2+ transport in low Mg(2+ conditions, we fed either a Mg-deficient diet or a Mg-containing diet (control to Wistar rats for 1-6 weeks. Total Mg concentrations in serum and cardiac ventricular tissues were measured by atomic absorption spectroscopy. Intracellular free Mg(2+ concentration ([Mg(2+]i of ventricular myocytes was measured with the fluorescent indicator furaptra. Mg(2+ transport rates, rates of Mg(2+ influx and Mg(2+ efflux, were estimated from the rates of change in [Mg(2+]i during Mg loading/depletion and recovery procedures. In Mg-deficient rats, the serum total Mg concentration (0.29±0.026 mM was significantly lower than in control rats (0.86±0.072 mM after 4-6 weeks of Mg deficiency. However, neither total Mg concentration in ventricular tissues nor [Mg(2+]i of ventricular myocytes was significantly different between Mg-deficient rats and control rats. The rates of Mg(2+ influx and efflux were not significantly different in both groups. In addition, quantitative RT-PCR revealed that Mg deficiency did not substantially change mRNA expression levels of known Mg(2+ channels/transporters (TRPM6, TRPM7, MagT1, SLC41A1 and ACDP2 in heart and kidney tissues. These results suggest that [Mg(2+]i as well as the total Mg content of cardiac myocytes, was well maintained even under chronic hypomagnesemia without persistent modulation in function and expression of major Mg(2+ channels/transporters in the heart.

  12. Porous Ceramic Composite ZrO2(MgO)-MgO for Osteoimplantology

    Buyakov, A. S.; Kulkov, S. N.


    Pore and crystalline structure, biocompatibility of ceramic composite ZrO2(MgO)-MgO were studied. The main mechanical characteristics were determined and it has been shown that compression strength directly depends on microstresses obtained from X-ray data. In-vitro studies of mesenchymal stromal stem cells (MMSC), cultivated on material surface are shown that cell proliferation and differentiation of MMSC goes throw osteogenic type.

  13. Flunarizine in migraine prophylaxis: efficacy and tolerability of 5 mg and 10 mg dose levels.

    Centonze, V; Magrone, D; Vino, M; Caporaletti, P; Attolini, E; Campanale, G; Albano, O


    The use of flunarizine, a drug which has proven its efficacy in migraine, is often associated with important side effects. The aim of this paper has been to check their incidence at different dose levels (5 mg vs 10 mg). Our data confirm the occurrence of important side effects (in particular weight gain); on the other hand, they emphasize the dose-dependency of the side effects.

  14. Laser cooling of MgCl and MgBr in theoretical approach

    Wan, Mingjie; Shao, Juxiang; Huang, Duohui; Yang, Junsheng; Cao, Qilong; Jin, Chengguo; Wang, Fanhou, E-mail: [Computational Physics Key Laboratory of Sichuan Province, Yibin University, Yibin 644007 (China); Gao, Yufeng [Institute of Atomic and Molecular Physics, Sichuan University, Chengdu 610065 (China)


    Ab initio calculations for three low-lying electronic states (X{sup 2}Σ{sup +}, A{sup 2}Π, and 2{sup 2}Π) of MgCl and MgBr molecules, including spin-orbit coupling, are performed using multi-reference configuration interaction plus Davidson correction method. The calculations involve all-electronic basis sets and Douglas–Kroll scalar relativistic correction. Spectroscopic parameters well agree with available theoretical and experimental data. Highly diagonally distributed Franck-Condon factors f{sub 00} for A{sup 2}Π{sub 3/2,1/2} (υ′ = 0) → X{sup 2}Σ{sup +}{sub 1/2} (υ″ = 0) are determined for both MgCl and MgBr molecules. Suitable radiative lifetimes τ of A{sup 2}Π{sub 3/2,1/2} (υ′ = 0) states for rapid laser cooling are also obtained. The proposed laser drives A{sup 2}Π{sub 3/2} (υ′ = 0) → X{sup 2}Σ{sup +}{sub 1/2} (υ″ = 0) transition by using three wavelengths (main pump laser λ{sub 00}; two repumping lasers λ{sub 10} and λ{sub 21}). These results indicate the probability of laser cooling MgCl and MgBr molecules.

  15. Fabrication of all-MgB Josephson junctions using MgO insulator layer

    Oba, T. [Graduate School of Engineering, Iwate University, 4-3-5, Ueda, Morioka 020-8551 (Japan); Goto, S. [Lightom, 95-2 Sugo, Takizawa 020-0173 (Japan); Sasaki, S.; Nakanishi, Y.; Fujino, T. [Graduate School of Engineering, Iwate University, 4-3-5, Ueda, Morioka 020-8551 (Japan); Harada, Y. [JST Satellite Iwate, Japan Science and Technology Agency, 3-35-2 Iiokashinden, Morioka, Iwate 020-0852 (Japan); Nakamura, M. [Graduate School of Engineering, Iwate University, 4-3-5, Ueda, Morioka 020-8551 (Japan); Saito, A. [Department of Electrical Engineering, Yamagata University, 4-3-16, Jonan, Yonezawa, Yamagata 992-8510 (Japan); Yoshizawa, M. [Graduate School of Engineering, Iwate University, 4-3-5, Ueda, Morioka 020-8551 (Japan)], E-mail:


    We report on the fabrication and properties of all-MgB{sub 2} tunnel junctions with an MgO barrier. Superconductor-insulator-superconductor (SIS) junctions were fabricated on C-plane sapphire substrates. MgB{sub 2} films were grown in an ultra-high vacuum in the 10{sup -9} Torr range. The MgO insulating layer was evaporated using an electron-beam gun. SIS junctions of 30 {mu}m in diameter were fabricated by standard photolithography and Ar ion milling techniques. The critical temperature (T{sub C}) of the lower MgB{sub 2} layer after the SIS junction fabrication process was 36.7 K, which remained the same as that of the bare MgB{sub 2} film. We observed tunneling behavior in the current-voltage (I-V) characteristics of the present junctions. A superconducting gap was clearly observed at around 2.7 mV (=2{delta})

  16. Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine.

    Láinez, M J A; Evers, S; Kinge, E; Allais, G; Allen, C; Rao, N A; Massaad, R; Lis, K


    Preference is a composite, patient-oriented endpoint incorporating efficacy, tolerability, formulation, and convenience of medications. The objective of this study was to compare patient preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine. In this multicentre, open-label, two-period, crossover study, out-patients were randomly assigned to treat the first of two moderate to severe migraines with rizatriptan or eletriptan and the second with the alternate therapy. Patients completed diary assessments at baseline and up to 24 h after taking study medication. At the last visit, patients completed a psychometrically validated preference questionnaire. A total of 372 patients (mean age 38 years, 85% female) treated two migraine attacks, and 342 patients (92%) expressed a preference for treatment. Significantly more (P rizatriptan 10-mg wafer [61.1%; 95% confidence interval (CI) 55.7, 66.3] to eletriptan 40-mg tablet (38.9%; 95% CI 33.7, 44.3). The most common reason given for preference of either treatment was speed of headache relief. At 2 h, 80% and 69% of patients reported that rizatriptan and eletriptan, respectively, was convenient or very convenient to take (mean convenience score 1.99 vs. 2.31, respectively; P rizatriptan 10-mg wafer to the eletriptan 40-mg tablet for acute treatment of migraine. The single most important reason for preference was speed of relief, consistent with results from previous preference studies.

  17. Laser cooling of MgCl and MgBr in theoretical approach.

    Wan, Mingjie; Shao, Juxiang; Gao, Yufeng; Huang, Duohui; Yang, Junsheng; Cao, Qilong; Jin, Chengguo; Wang, Fanhou


    Ab initio calculations for three low-lying electronic states (X(2)Σ(+), A(2)Π, and 2(2)Π) of MgCl and MgBr molecules, including spin-orbit coupling, are performed using multi-reference configuration interaction plus Davidson correction method. The calculations involve all-electronic basis sets and Douglas-Kroll scalar relativistic correction. Spectroscopic parameters well agree with available theoretical and experimental data. Highly diagonally distributed Franck-Condon factors f00 for A(2)Π3/2,1/2 (υ' = 0) → X(2)Σ(+) 1/2 (υ″ = 0) are determined for both MgCl and MgBr molecules. Suitable radiative lifetimes τ of A(2)Π3/2,1/2 (υ' = 0) states for rapid laser cooling are also obtained. The proposed laser drives A(2)Π3/2 (υ' = 0) → X(2)Σ(+) 1/2 (υ″ = 0) transition by using three wavelengths (main pump laser λ00; two repumping lasers λ10 and λ21). These results indicate the probability of laser cooling MgCl and MgBr molecules.

  18. Raman scattering study of α-MgH2 and γ-MgH2

    Kuzovnikov, M. A.; Efimchenko, V. S.; Filatov, E. V.; Maksimov, A. A.; Tartakovskii, I. I.; Ramirez-Cuesta, A. J.


    Two modifications of MgH2 have been studied by Raman spectroscopy: α-MgH2 with the P42/mnm space group and γ-MgH2 with the Pbcn space group. The latter was prepared from α-MgH2 by exposing it to a pressure of 5.6 GPa at 470 °C for 1.5 h. A comparison of the experimental spectra with ab-initio calculations allowed identification of a few phonon modes. A broad feature in the Raman spectrum of α-MgH2 in the range 1470-1790 cm-1 was identified as the B2g phonon mode. A Raman spectrum of γ-MgH2 consists of five discernible peaks at 186 cm-1, 313 cm-1, 509 cm-1, 660 cm-1, 706 cm-1 and of three broad features in the regions 890-980 cm-1, 1010-1220 cm-1 and 1240-1430 cm-1. The peaks are identified as the 1Ag (186 cm-1), 3B3g (509 cm-1), 2Ag (660 cm-1) and 3B1g (706 cm-1) phonon modes.

  19. Dehydrogenation kinetics of air-exposed MgH2/Mg2Cu and MgH2/MgCu2 studied with in situ X-ray powder diffraction

    Andreasen, A.; Sørensen, M.B.; Burkarl, R.


    The dehydrogenation kinetics of air exposed samples of MgH2/Mg2Cu and MgH2/MgCu2 have been studied with in situ time resolved X-ray powder diffraction. The X-ray setup enabled the recording of full diffraction patterns within 150 s, thereby allowing the study of structural changes combined...... sample was found to be 108 kJ/mol and 160 kJ/mol, respectively. Furthermore, substantially improved dehydrogenation kinetics of MgH2 and resistance towards oxidation of Mg due to the presence of Mg2Cu/MgCu2 are discussed in relation to previous work....

  20. Two Proton Knockout from ^32Mg

    Fallon, P.; Rodriguez-Vieitez, E.; Macchiavelli, A. O.; Clark, R. M.; Lee, I.-Y.; Wiedeking, M.; Gade, A.; Adrich, P.; Bazin, D.; Bowen, M.; Campbell, C. M.; Cook, J. M.; Dinca, D. C.; Glasmacher, T.; McDaniel, S.; Mueller, W. F.; Ratiewicz, A. F.; Siwek, K.; Terry, J. R.; Wiesshaar, D.; Yoneda, K.; Brown, B. A.; Otsuka, T.; Tostevin, J. A.; Utsuno, Y.


    We present data and calculations on the near-dripline nucleus ^30Ne. Gamma-ray decays from excited states as well as inclusive and exclusive cross-sections were measured in the ^9Be(^32Mg,^30Ne γ)X two-proton knockout reaction at incident beam energies of 99.7 and 86.7 MeV/A. The measured inclusive cross section sigma = 0.22(4)mb is suppressed compared to calculation and is indicative of a reduced overlap of initial and final state wavefunctions. We interpret this reduction as a result of large 4p4h intruder components present in ^30Ne, but not ^32Mg. Large 4p4h amplitudes are predicted to generate increased T=1 paring strengths and to help stabilize the heavier fluorine isotopes against neutron decay. A new gamma-ray transition at 1443 keV is assigned to the decay of the 4^+ state based on the spin dependent sigma for 2 proton knockout from the (d5/2)^4 configuration.

  1. Materials science of Mg-Ni-based new hydrides

    Orimo, S.; Fujii, H. [Hiroshima Univ. (Japan). Faculty of Integrated Arts and Sciences


    One of the advantageous functional properties of Mg alloys (or compounds) is to exhibit the reversible hydriding reaction. In this paper, we present our systematic studies regarding the relationship between nanometer- or atomistic-scale structures and the specific hydriding properties of the Mg-Ni binary system, such as(1) nanostructured (n)-Mg{sub 2}Ni, (2) a mixture of n-Mg{sub 2}Ni and amorphous (a)-MgNi,(3) pure a-MgNi, and(4) n-MgNi{sub 2}. Further studies on(5) an a-MgNi-based system for clarifying the effect of the short-range ordering on the structural and hydriding properties and(6) a MgNi{sub 2}-based system for synthesizing the new Laves phase structure are also presented. The materials science of Mg-Ni-based new hydrides will provide indispensable knowledge for practically developing the Mg alloys as hydrogen-storage materials. (orig.)

  2. Factors Influencing MgO Content of RE-Mg Nodularizing Alloy%REMg球化剂中MgO含量的影响因素

    杨宇鹏; 肖勇


    The effect of Mg in nodularizing alloy was introduced.When the total content of Mg was constant,the formation of MgO reduced the content of the effective Mg that would influence the nodularizing capability of the nodualrizing alloy.The source of MgO in nodularizing alloy was analyzed as follows:the MgO formed during the melting process of the nodularizing alloy and the MgO formed during the analysis sample preparing process.It was pointed out after analyzing two cases:(1) the MgO content of nodularizing alloy is the main factor influencing its nodularzing capability,therefore the MgO content should be reduced by improving its melting process; (2)In order to ensure the veracity of MgO content test it's necessary to use correct sample preparing method.%介绍了Mg在球化剂中的作用.当w(Mg总)一定时,MgO的生成降低了w(Mg有效)的含量,影响到球化剂的球化能力.分析了球化剂中MgO的来源:球化剂熔炼过程中产生MgO、在制取分析样品过程中产生MgO.通过2个案例的分析,指出:(1)球化剂中MgO含量的高低是影响其球化能力的主要因素,应通过改进熔炼工艺来降低w(MgO)量;(2)为确保球化剂中w(MgO)量检测的准确性,应采用正确的样品制备方法.

  3. Screening and confirming of target strains from the faeces of rats fed with lactobacilli strains feed to SD rat%乳杆菌喂食大鼠后目标菌克隆筛选与确认

    何琼伟; 陶祝华; 朱一力; 郑刚; 李伟莉; 林蓉; 金嵘; 陈龙; 曾爱兵


    目的 确认乳杆菌能否顺利通过胃酸屏障并在肠道内定植为进一步研究乳杆菌对大鼠的生理代谢影响做基础,为乳杆菌菌株的应用提供有效依据.方法 采用浓度梯度药物平板筛选利福平耐受菌株,用耐利福平(15 mg/L)乳杆菌菌株喂食SD雄性大鼠并采集其新鲜粪便,在耐药平板上筛选出能在大鼠结肠内定植良好的耐药菌株,并得到16S rDNA的鉴定结果,利用16S rDNA序列同源性分析对乳酸菌进行分类鉴定.结果 粪便中检测出的乳杆菌耐药菌株经纯化鉴定后与所喂食的乳杆菌同源.结论 实验所筛选出的耐利福平乳杆菌在大鼠结肠内成功定植.%Objective To confirm whether lactobacilli could overcome the gastric acid barrier and localize in the intestines of rats, so to provide basis for further studies on the effect of lactobacilli's localization on rats' physiological characteristics and for the application of the strains. Method Plates with grediant concentration of rifampicin were used to screen the resistant strains. Rifampicin-resistant lactobacilli ( > 15 μg/mL) were fed to SD and then the fresh faeces of the SD male rats were collected. The strains which could localize in rats' colons well were then genetically identified with 16S rDNA sequence analysis. Result After purification, the lactobacilli resistant strains detected from the male rats' faeces were identified as homologous to the fed ones. Conclusion The lactobacifius strains screened in this study can localize stably in rat's colon.

  4. Prevalence of gastroduodenal ulcers/erosions in patients taking low-dose aspirin with either 15 mg/day of lansoprazole or 40 mg/day of famotidine: the OITA-GF study 2.

    Tamura, Akira; Murakami, Kazunari; Kadota, Junichi


    The preventive effects of histamine 2 receptor antagonists vs. proton pump inhibitors on low-dose aspirin (LDA)-related gastroduodenal mucosal injury have not been fully investigated. We conducted a cross-sectional study to compare the prevalence of gastroduodenal ulcers or erosions in patients taking LDA with either 40 mg/day of famotidine or 15 mg/day of lansoprazole for at least three months. Of 84 eligible patients, two taking 40 mg/day of famotidine and four taking 15 mg/day of lansoprazole refused to undergo upper gastrointestinal endoscopy. Ultimately, we performed upper gastrointestinal endoscopy in 78 patients taking either 40 mg/day of famotidine (group F, n = 31) or 15 mg/day of lansoprazole (group L, n = 47). The prevalence of gastroduodenal ulcers or erosions and the magnitude of gastric mucosal injury evaluated using modified Lanza scores were compared between the two groups. No patients in either group had gastroduodenal ulcers. Gastroduodenal erosions were more prevalent in group F than in group L (48.4% vs. 17.0%, p = 0.005). The modified Lanza scores (mean ± SD) were significantly higher in group F than in group L (0.9 ± 1.3 vs. 0.3 ± 0.7, p = 0.007). A multivariate logistic regression analysis showed that the use of lansoprazole was negatively associated with gastroduodenal erosions. This study suggests that 15 mg/day of lansoprazole may be more effective in preventing the development of LDA-related gastroduodenal erosions than 40 mg/day of famotidine. The preventive effects of these two regimens on the development of LDA-related gastroduodenal ulcers require further investigation.

  5. Effect of Mg and C contents in MgCNi3, and structure and superconductivity of MgCNi3-xCox


    The effect of Mg and C contents on TC in MgCNi3, and structure and superconductivity of MgCNi3-xCox were studied. It is found that the excess of Mg and C in initial material mixture is favorable to improvement in TC and helps to obtain single_phase samples. For preparing MgCNi3 superconductor, the optimum composition of starting materials is MgC1.45Ni3 with excess of Mg (20 wt.%) of the stoichiometric composition. In MgCNi3-xCox system, a continuous solid solution is formed, lattice parameter decreases slightly and TC decreases obviously with increasing x. A suppression of superconductivity is observed due to the substitution of Co (Mn) for Ni. The suppression effect is smaller for the substitution of Co than that of Mn.

  6. Effects of Soluble Phosphate on Phosphate-Solubilizing Characteristics and Expression of gcd Gene in Pseudomonas frederiksbergensis JW-SD2.

    Zeng, Qingwei; Wu, Xiaoqin; Wen, Xinyi


    Phosphate-solubilizing bacteria have the ability of solubilizing mineral phosphate in soil and promoting growth of plants, but the activity of phosphate solubilization is influenced by exogenous soluble phosphate. In the present study, the effects of soluble phosphate on the activity of phosphate solubilization, acidification of media, growth, and organic acid secretion of phosphate-solubilizing bacterium Pseudomonas frederiksbergensis JW-SD2 were investigated under six levels of soluble phosphate conditions. The activity of phosphate solubilization decreased with the increase of soluble phosphate concentration, accompanying with the increase of media pH. However, the growth was promoted by adding soluble phosphate. Production of gluconic, tartaric, and oxalic acids by the strain was reduced with the increase of concentration of soluble phosphate, while acetic and pyruvic acids showed a remarkable increase. Gluconic acid predominantly produced by the strain at low levels of soluble phosphate showed that this acid was the most efficient organic acid in phosphate solubilization. Pyrroloquinoline quinone-glucose dehydrogenase gene gcd (pg5SD2) was cloned from the strain, and the expressions of pg5SD2 gene were repressed gradually with the increase of concentration of soluble phosphate. The soluble phosphate regulating the transcription of the gcd gene is speculated to underlie the regulation of the secretion of gluconic acid and subsequently the regulation of the activity of phosphate solubilization. Future research needs to consider a molecular engineering strategy to reduce the sensitivity of PSB strain to soluble phosphate via modification of the regulatory mechanism of gcd gene, which could improve the scope of PSB strains' application.

  7. Electrochemical formation of Mg-Li-Ca alloys by codeposition of Mg, Li and Ca from LiCl-KCl-MgCl2-CaCl2 melts.

    Yan, Yong De; Zhang, Mi Lin; Xue, Yun; Han, Wei; Cao, Dian Xue; Jing, Xiao Yan; He, Li Yi; Yuan, Yi


    This work presents electrochemical formation of Mg-Li-Ca alloys via codeposition of Mg, Li and Ca on a molybdenum electrode in KCl-LiCl-MgCl(2)-CaCl(2) melts at 943 K. Cyclic voltammograms (CVs) showed that the underpotential deposition (UPD) of calcium on pre-deposited magnesium leads to the formation of a liquid Mg-Ca alloy, and the succeeding underpotential deposition of lithium on pre-deposited Mg-Ca alloy leads to the formation of a liquid Mg-Li-Ca solution. Chronopotentiometric measurements indicated that the codepositon of Mg, Li and Ca occurs at current densities more negative than -0.31 A cm(-2) in LiCl-KCl-MgCl(2) (5 wt%) melts containing 1 wt% CaCl(2). Chronoamperograms demonstrated that the onset potential for the codeposition of Mg, Li and Ca is -2.200 V, and the codeposition of Mg, Li and Ca is formed when the applied potentials are more negative than -2.200 V. X-Ray diffraction (XRD) indicated that Mg-Li-Ca alloys with different phases were formed via galvanostatic electrolysis. The microstructures of typical alpha and beta phases of Mg-Li-Ca alloys were characterized by optical microscope (OM) and scanning electron microscopy (SEM). The analysis of energy dispersive spectrometry (EDS) showed that the element Ca mainly distributes along grain boundary in Mg-Li-Ca alloys. The results of inductively coupled plasma analysis determined that the chemical compositions of Mg-Li-Ca alloys correspond with the phase structures of XRD patterns, and the lithium and calcium contents of Mg-Li-Ca alloys depend on the concentrations of MgCl(2) and CaCl(2).

  8. Decay of a narrow and high spin {sup 24}Mg + {sup 24}Mg resonance

    Salsac, M.-D. [IPHC, Universite Louis Pasteur, CNRS-IN2P3, Strasbourg (France)], E-mail:; Haas, F.; Courtin, S. [IPHC, Universite Louis Pasteur, CNRS-IN2P3, Strasbourg (France); Algora, A. [INR, Debrecen (Hungary); Beck, C. [IPHC, Universite Louis Pasteur, CNRS-IN2P3, Strasbourg (France); Beghini, S. [Universita di Padova and INFN, Padova (Italy); Behera, B.R. [INFN Laboratori Nazionali di Legnaro, Legnaro (Italy); Chapman, R. [University of the West of Scotland, Paisley (United Kingdom); Corradi, L. [INFN Laboratori Nazionali di Legnaro, Legnaro (Italy); Dombradi, Z. [INR, Debrecen (Hungary); Farnea, E. [Universita di Padova and INFN, Padova (Italy); Fioretto, E.; Gadea, A. [INFN Laboratori Nazionali di Legnaro, Legnaro (Italy); Jenkins, D.G. [University of York, York (United Kingdom); Latina, A. [INFN Laboratori Nazionali di Legnaro, Legnaro (Italy); Lebhertz, D. [IPHC, Universite Louis Pasteur, CNRS-IN2P3, Strasbourg (France); Lenzi, S. [Universita di Padova and INFN, Padova (Italy); Liang, X. [University of the West of Scotland, Paisley (United Kingdom); Marginean, N. [INFN Laboratori Nazionali di Legnaro, Legnaro (Italy); Montagnoli, G. [Universita di Padova and INFN, Padova (Italy)] (and others)


    The {sup 24}Mg + {sup 24}Mg reaction has been studied at the Legnaro Tandem at a CM bombarding energy of 45.7 MeV where a narrow and high spin resonance has been reported previously. The decay of the resonance into the inelastic and fusion-evaporation channels has been investigated. The ON and OFF resonance decay yields have been measured using, for the inelastic channels, the fragment spectrometer PRISMA and the {gamma} array CLARA, and, for the fusion-evaporation channels, the Si array EUCLIDES and the {gamma} array GASP. Strong resonant effects have been observed in the inelastic channels involving the 2{sub 1}{sup +} and 4{sub 1}{sup +} states of the {sup 24}Mg ground state band. Weaker effects are also seen in certain fusion-evaporation channels. The properties of the studied resonance are in agreement with molecular model predictions. It is also proposed that the narrow and high spin {sup 24}Mg + {sup 24}Mg resonance corresponds to the formation of a fast rotating and highly prolate deformed {sup 48}Cr after a Jacobi shape transition and just before fission.

  9. Mechanical Properties of Mg-Gd and Mg-Y Solid Solutions

    Kula, Anna; Jia, Xiaohui; Mishra, Raj K.; Niewczas, Marek


    The mechanical properties of Mg-Gd and Mg-Y solid solutions have been studied under uniaxial tension and compression between 4 K and 298 K (-269 °C and 25 °C). The results reveal that Mg-Gd alloys exhibit higher strength and ductility under tension and compression attributed to the more effective solid solution strengthening and grain-boundary strengthening effects. Profuse twinning has been observed under compression, resulting in a material texture with strong dominance of basal component parallel to compression axis. Under tension, twining is less active and the texture evolution is controlled mostly by slip. The alloys exhibit pronounced yield stress asymmetry and significantly different work-hardening behavior under tension and compression. Increasing of Gd and/or Y concentration leads to the reduction of the tension-compression asymmetry due to the weakening of the recrystallization texture and more balanced twinning and slip activity during plastic deformation. The results suggest that under compression of Mg-Y alloys slip is more active than twinning in comparison to Mg-Gd alloys.

  10. Refinements in an Mg/MgH2/H2O-Based Hydrogen Generator

    Kindler, Andrew; Huang, Yuhong


    Some refinements have been conceived for a proposed apparatus that would generate hydrogen (for use in a fuel cell) by means of chemical reactions among magnesium, magnesium hydride, and steam. The refinements lie in tailoring spatial and temporal distributions of steam and liquid water so as to obtain greater overall energy-storage or energy-generation efficiency than would otherwise be possible. A description of the prior art is prerequisite to a meaningful description of the present refinements. The hydrogen-generating apparatus in question is one of two versions of what was called the "advanced hydrogen generator" in "Fuel-Cell Power Systems Incorporating Mg-Based H2 Generators" (NPO-43554), NASA Tech Briefs, Vol. 33, No. 1 (January 2009), page 52. To recapitulate: The apparatus would include a reactor vessel that would be initially charged with magnesium hydride. The apparatus would exploit two reactions: The endothermic decomposition reaction MgH2-->Mg + H2, which occurs at a temperature greater than or equal to 300 C, and The exothermic oxidation reaction MgH2 + H2O MgO + 2H2, which occurs at a temperature greater than or equal to 330 C.

  11. SD大鼠腰神经根的解剖学观察%Anatomical observation of the lumbar nerve roots in SD rat

    钟贵彬; 李伟; 刘祖德; 王涵韬; 倪鹏文; 乔之光


    Objective To provide anatomical basis for the functional reconstruction of the lumbar root after spinal cord injury. Methods Anatomical features of the lumbar roots were observed and summarized on 30 SD rats during the operation and on 10 SD rats microdissected after perfusion. Results There were six couples of the lumbar roots in SD rat. The L2-L4 roots mainly made up femoral nerve which dominating the quadriceps femoris. Sciatic nerve was composed of the L5-L6 roots which dominating the dorsal femoris muscle group. The lumbar medullary originated at the 12th thoracal vertebra and terminated at the 2th lumbar vertebra. The lumbar anterior root with one bunch was thin and its posterior root with two bunches was thick. Its anterior root and posterior root were wrapped together in one dura mater of spinal cord. The dura mater of spinal cord was thick and solid. The ventral and dorsal foots of spinal nerves were surrounded by meningeal tubes seperately till the point of dorsal root ganglion. Conclusions There are some difference in anatomical character of lumbar roots between SD rat and human.%目的 为从腰神经根途径开展脊髓损伤后肢体运动功能重建的研究提供解剖依据.方法 对10只SD大鼠灌注后进行显微解剖研究,并对30只SD大鼠进行手术中观察和测量,观察腰神经根的解剖特点.结果 SD大鼠腰神经根共有6对,其中L2~4组成股神经支配股四头肌,L5~6组成坐骨神经支配股后肌群,腰髓约平对T12,13及L1、2水平.腰神经前根l束较细,后根2束较粗,腰神经前、后根出硬膜后,有各自独立的硬膜囊包绕后直至后根神经节处.结论 SD大鼠腰神经根解剖特征与人类不同.

  12. 青年SD大鼠营养性肥胖模型的建立%The Establishment of Young SD Rats Model of Nutritional Obesity

    曹翠玲; 许之屏; 伍光; 马恋


    Objective To establish a model of the young nutritional obesity SD rats. Methods 40 4-weeks old SD rats were fed on normal diet for 3 days in sense of adaptability, then randomly separated into two groups. The normal control group was given normal diet, model group was given modified fat diet, in total of 8 weeks. Monitoring the weight, Lee's index and serum lipids, total cholesterol (TC), triglyceride (TG), low density lipopro-tein (LDL-C) changes in control group and model group. Results After 8 weeks, the model group weight, Lees in-dex, total cholesterol (TC), triglyceride (TG), low density lipoprotein were significantly higher (P<0.05, P <0.01) than normal group. Conclusion The modified high-fat diet recipes that cater SD rat molar habits, undertaking mixed feeding methods for a reasonable feeding time can trigger young SD rats nutritional obesity, which caused the fat rate reached 83%.%目的:建立青年SD大鼠营养性肥胖模型。方法:出生4周的40只SD大鼠将其随机分为对照组与模型组,对照组给予普通饲料,模型组给予改良的高脂饲料,共饲养8周。观察对照组与模型组体重、Lee's指数及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)的变化情况。结果:在高脂饲养8周后,模型组平均体重、Lee's指数、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白均明显高于对照组(P<0.05)。结论:改良高脂饲料配方、迎合SD大鼠磨牙习性和混合喂养方式可以诱导青年SD大鼠营养性肥胖,致肥率达到83%。

  13. Etats intrus dans les noyaux de la couche sd : de 1p-1t à np-nt dans les isotopes de Si

    Goasduff, Alain


    New large-scale shell-model calculations with full 1¯hω valence space for the sd-nuclei has been used for the first time to predict lifetimes of positive and negative parity states in neutron rich Si isotopes. The predicted lifetimes (1 - 100 ps) fall in the range of the differential Doppler shift method. Using the demonstrator of the European next generation γ-ray array, AGATA, in coincidence with the large acceptance PRISMA magnetic spectrometer from LNL (Legnaro) and the differential plung...

  14. DARPA Antibody Technology Program Standardized Test Bed for Antibody Characterization: Characterization of an MS2 sdAb Produced by U.S. Naval Research Laboratory


    of each sample to prevent sample evaporation. The plate was then placed into a DynaPro temperature-controlled plate reader (Wyatt Technology). Each...Differential Scanning Calorimetry (DSC) DSC was used to obtain a quantitative melting temperature (Tm) for each of the NRL MS2 sdAb proteins. The...tubes. One aliquot was kept on ice for the duration of the experiment and was marked “time 0”. The remaining four aliquots were heated to 70 °C on a

  15. Formation and Stability of Hollow MgO Nanoshells

    Krishnan, G.; Palasantzas, G.; Kooi, B.J.


    High temperature annealing of gas phase synthesized Mg nanoparticles surrounded by an MgO shell leads to formation of hollow MgO nanoshells due to the evaporation assisted Kirkendall effect. Under electron beam exposure in TEM, the (220) MgO facets reduce their high surface energy by forming cube fa

  16. cDNA library Table: mg [KAIKOcDNA[Archive

    Full Text Available mg NA mg-- p50 midgut fifth instar larval stage D3 mixed pBluescript SK- EcoR1 for ...5' Xho1for 3' sequenced from T3 primer (5' -> 3') AU001868-AU002476,BY916287-BY916543 mg[number],mg[number]_1 ...

  17. Simultaneous polymerization of Mg and Zr alkoxides

    Mendez-Vivar, J.; Lara, V.H. [Univ. Autonoma Metropolitana-Iztapalapa, Depto. de Quimica, Mexico, D. F. (Mexico); Mendoza-Serna, R.; Ayala-Morales, A. [Facultad de Estudios Superiores Zaragoza, UNAM, Carrera de Ingenieria Quimica, Mexico, D. F. (Mexico); Bosch, P. [Inst. de Investigaciones en Materiales, UNAM Circuito Exterior, Mexico, D. F. (Mexico)


    The preparation of homogeneous MgO-ZrO{sub 2} ceramics by the sol-gel process is of interest because of its potential technological applications as dielectric materials in thin films and membranes. In this work we used magnesium methoxide and zirconium n-propoxide as precursors. The simultaneous polymerization of the alkoxides was performed via the sol-gel process, using acetylacetone (acacH) and isoeugenol (isoH) separately as the chelating agents, in order to control the hydrolysis and condensation steps. Spectroscopic studies have been performed on the sols, gels, xerogels and oxides, including Fourier transform infrared (FTIR) spectroscopy and small Angle X-ray Scattering (SAXS). (orig.)

  18. Mg II Absorbing Galaxies: Morphologies and Kinematics

    Churchill, C; Kacprzak, G G; Churchill, Chris; Steidel, Chuck; Kacprzak, Glenn


    In this contribution, we review our current knowledge of the properties of galaxies, and their extended halos, selected by MgII absorption in the spectra of background quasars. We then describe recent efforts to quantify the morphologies and orientations of galaxies and explore how these relate to the gas kinematics. In a sample of 26 galaxies, we find no clear connection between the orientation of the quasar line of sight through the galaxy and the velocity spread of the gas. However, it appears that the quantity of gas "stirred up" in the halo may be correlated to asymmetry in the galaxy morphology. Since the galaxies have fairly normal morphologies, this connection may suggest that galaxies with extended halos experienced an interaction or merging event a few dynamical times prior to the epoch of observation.

  19. Multiaxial magnetic ordering in NdMg

    Deldem, M; Galera, R M; Morin, P; Schmitt, D; Ouladdiaf, B


    NdMg is a cubic compound (CsCl-type) which orders antiferromagnetically at T sub N =61 K. The magnetization measurements show a second transition at T sub R =35 K. Over the whole order range, the powder neutron diffraction pattern can be indexed on the hypothesis of a collinear structure, the magnetic moments being parallel to the wave vector. The neutron diffraction experiments on a single crystal, under an applied magnetic field, establish that the transition at T sub R corresponds to a change from a collinear structure to a multiaxial one. The magnetic moments successively point along a fourfold axis, in the collinear structure, and along twofold axes in the multiaxial one. This sequence of magnetic structures is consistent with the coexistence of ferroquadrupolar gamma-couplings and antiferroquadrupolar epsilon-couplings. (author)

  20. Preparation of Mg-MgH2 flakes by planetary ball milling with stearic acid and their hydrogen storage properties

    Hong, Seong-Hyeon; Song, Myoung Youp


    Many studies preparing magnesium hydride using catalyst addition were performed, resulting in the preparation of additive-containing magnesium hydride. Preparation of a sample with a MgH2 phase without additives requires high pressure and high temperature and is time-demanding. In order to prepare an additive-free sample with a MgH2 phase, 90 wt% Mg+10 wt% MgH2 (named 90Mg+10MgH2) was milled under a hydrogen atmosphere with 6 wt% stearic acid as a process-controlling agent, which led to a formation of Mg-MgH2 flakes. The hydrogen storing and releasing properties of the prepared flakes were investigated and compared with those of purchased MgH2. A sample with a majority fraction of MgH2 phase was prepared by planetary ball milling of 90 Mg+10 MgH2 with 6 wt% stearic acid. The resultant particles of 90 Mg+10 MgH2 obtained after hydridingdehydriding cycling were much smaller and had significantly more cracks and defects than those of MgH2 after hydriding-dehydriding cycling. 90 Mg+10 MgH2 released 0.12 wt% hydrogen for 4 min, 3.70 wt% for 20 min, and 5.30 wt% for 60 min at 648 K at the first cycle.