In vivo EPR oximetry using an isotopically-substituted nitroxide: Potential for quantitative measurement of tissue oxygen

Science.gov (United States)

Weaver, John; Burks, Scott R.; Liu, Ke Jian; Kao, Joseph P.Y.; Rosen, Gerald M.

2017-01-01

Variations in brain oxygen (O2) concentration can have profound effects on brain physiology. Thus, the ability to quantitate local O2 concentrations noninvasively in vivo could significantly enhance understanding of several brain pathologies. However, quantitative O2 mapping in the brain has proven difficult. The electron paramagnetic resonance (EPR) spectra of nitroxides are sensitive to molecular O2 and can be used to estimate O2 concentrations in aqueous media. We recently synthesized labile-ester-containing nitroxides, such as 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 4), which accumulate in cerebral tissue after in situ hydrolysis, and thus enable spatial mapping of O2 concentrations in the mouse brain by EPR imaging. In an effort to improve O2 quantitation, we prepared 3-acetoxymethox ycarbonyl-2,2,5,5-tetra(2H3)methyl-1-(3,4,4-2H3,1-15N)pyrrolidinyloxyl (nitroxide 2), which proved to be a more sensitive probe than its normo-isotopic version for quantifying O2 in aqueous solutions of various O2 concentrations. We now demonstrate that this isotopically substituted nitroxide is ~2-fold more sensitive in vivo than the normo-isotopic nitroxide 4. Moreover, in vitro and in vivo EPR spectral-spatial imaging results with nitroxide 2 demonstrate significant improvement in resolution, reconstruction and spectral response to local O2 concentrations in cerebral tissue. Thus, isotopic-substituted nitroxides, such as 2, are excellent sensors for in vivo O2 quantitation in tissues, such as the brain. PMID:27567323

Novel Profluorescent Nitroxides for Monitoring Alkyl Radical Reactions During Radiation Degradation

International Nuclear Information System (INIS)

George, G.

2006-01-01

Hindered amine stabilizers (HAS) are effective at retarding the photo-oxidative and high energy radiation degradation of PP and in certain circumstances, also thermo-oxidative degradation. The effectiveness of HAS as retarders of oxidation relies on the oxidation of the N-C bond by polymer hydroperoxide, ROOH, to form the nitroxyl group -NO which is the scavenger of polymer alkyl radicals, R. This reaction, which produces the alkoxy amine: -NO-R, must be competitive with the reaction of R with oxygen (which gives the chain-carrying peroxy radical, RO 2 ) if this stabilization mechanism is to be important in the inhibition of radiation-induced oxidative degradation of polyolefins by HAS. The rate of this reaction is high and in solution the rate coefficient is from 1 to 9x10 8 l mol - 1 s - 1. The efficient radical trapping by nitroxides has been widely employed in spin-trapping studies by electron spin resonance (esr) spectroscopy]. In addition to the hindered piperidine structure of commercial HAS, more rigid aromatic systems have been studied that are more stable to oxidative degradation and are more efficient at scavenging alkyl radicals. One such family is the iso-indoline nitroxide system, TMDBIO, shown below which, as it contains the phenanthrene fluorophore, is termed phenanthrene nitroxide. This nitroxide only becomes fluorescent when it reacts with alkyl radicals or is reduced and is termed profluorescent. TMDBIO has a vanishingly small fluorescence quantum yield (φ∼10 - 4) due to the enhanced intersystem crossing from the first excited singlet state to the ground state due to electron exchange interactions of the nitroxyl radical. When the nitroxide traps an alkyl radical, R, the resulting alkoxy amine is fluorescent (φ∼10 - 1) and the emission intensity is a measure of the number of reactions that have occurred. This property may be exploited by using quantitative fluorescence spectroscopy to follow the reaction of the nitroxide with alkyl radicals

Clearance and Biodistribution of Liposomally Encapsulated Nitroxides: A Model for Targeted Delivery of Electron Paramagnetic Resonance Imaging Probes to Tumors

Science.gov (United States)

Burks, Scott R.; Legenzov, Eric A.; Rosen, Gerald M.

2011-01-01

Electron paramagnetic resonance (EPR) imaging using nitroxides as molecular probes is potentially a powerful tool for the detection and physiological characterization of micrometastatic lesions. Encapsulating nitroxides in anti-HER2 immunoliposomes at high concentrations to take advantage of the “self-quenching” phenomenon of nitroxides allows generation of robust EPR signals in HER2-overexpressing breast tumor cells with minimal background from indifferent tissues or circulating liposomes. We investigated the in vivo pharmacological properties of nitroxides encapsulated in sterically stabilized liposomes designed for long circulation times. We show that circulation times of nitroxides can be extended from hours to days; this increases the proportion of liposomes in circulation to enhance tumor targeting. Furthermore, nitroxides encapsulated in sterically stabilized anti-HER2 immunoliposomes can be delivered to HER2-overexpressing tumors at micromolar concentrations, which should be imageable by EPR. Lastly, after in vivo administration, liposomally encapsulated nitroxide signal also appears in the liver, spleen, and kidneys. Although these organs are spatially distinct and would not hinder tumor imaging in our model, understanding nitroxide signal retention in these organs is essential for further improvements in EPR imaging contrast between tumors and other tissues. These results lay the foundation to use liposomally delivered nitroxides and EPR imaging to visualize tumor cells in vivo. PMID:21737567

Development of nitroxide radicals–containing polymer for scavenging reactive oxygen species from cigarette smoke

International Nuclear Information System (INIS)

Yoshitomi, Toru; Kuramochi, Kazuhiro; Binh Vong, Long; Nagasaki, Yukio

2014-01-01

We developed a nitroxide radicals–containing polymer (NRP), which is composed of poly(4-methylstyrene) possessing nitroxide radicals as a side chain via amine linkage, to scavenge reactive oxygen species (ROS) from cigarette smoke. In this study, the NRP was coated onto cigarette filters and its ROS-scavenging activity from streaming cigarette smoke was evaluated. The intensity of electron spin resonance signals of the NRP in the filter decreased after exposure to cigarette smoke, indicating consumption of nitroxide radicals. To evaluate the ROS-scavenging activity of the NRP-coated filter, the amount of peroxy radicals in an extract of cigarette smoke was measured using UV–visible spectrophotometry and 1,1-diphenyl-2-picrylhydrazyl (DPPH). The absorbance of DPPH at 517 nm decreased with exposure to cigarette smoke. When NRP-coated filters were used, the decrease in the absorbance of DPPH was prevented. In contrast, both poly[4-(cyclohexylamino)methylstyrene]- and poly(acrylic acid)-coated filters, which have no nitroxide radical, did not show any effect, indicating that the nitroxide radicals in the NRP scavenge the ROS in cigarette smoke. As a result, the extract of cigarette smoke passed through the NRP-coated filter has a lower cellular toxicity than smoke passed through poly[4-(cyclohexylamino)methylstyrene]- and poly(acrylic acid)-coated filters. Accordingly, NRP is a promising material for ROS scavenging from cigarette smoke. (papers)

Spin labelling of human erythrocytes with nitroxide radicals

International Nuclear Information System (INIS)

Chagalj, C.; DePaoli, T.C.P.; Hager, A.A.; Palaoro, L.A.; Rubin de Celis, E.; Farach, H.A.; Poole, C.P. jr

1984-01-01

Human erythrocytes were labelled with nitroxide, the spin label SYNVAR 101, under various experimantal conditions. A study was made of the influence of antireductants on the labelling efficiency and the kinetics of the radical decay during the labelling process

Nitroxide radicals as contrast substances for magnetic resonance imaging diagnostics. Part 1

International Nuclear Information System (INIS)

Zhelev, Z.

2016-01-01

In last ten years, there is a significant progress in the selective and localized detection of redox-active compounds in the cells, tissues, and intact organisms. This progress is due to the development of new synthetic and genetically encoded redox-sensitive contrast substances, as well as due to the improvement of the techniques for their imaging: fluorescent, chemiluminescent, magnetic resonance, nuclear, ultrasonic. One of the most attractive redox-sensitive contrast substances are cyclic (stable) nitroxide radicals. They can be visualized and analyzed in vitro and in vivo by a variety of magnetic resonance techniques - electron-paramagnetic resonance imaging (EPRI), magnetic resonance imaging (MRI), Overhauser-enhanced MRI (OMRI). This review describes the merits and demerits of the nitroxide-enhanced EPR and MRI and the perspectives for their application in biomedical studies and clinical practice. The article is intended for a wide range of readers - from students to specialists in the field. Key words: Magnetic Resonance Imaging (MRI). Electron-Paramagnetic Resonance (EPR). Overhauser-Enhanced MRI (O MRI). Nitroxide

Nitroxide radicals as research tools: Elucidating the kinetics and mechanisms of catalase-like and "suicide inactivation" of metmyoglobin.

Science.gov (United States)

Samuni, Uri; Czapski, Gideon; Goldstein, Sara

2016-07-01

Metmyoglobin (MbFe(III)) reaction with H(2)O(2) has been a subject of study over many years. H(2)O(2) alone promotes heme destruction frequently denoted "suicide inactivation," yet the mechanism underlying H(2)O(2) dismutation associated with MbFe(III) inactivation remains obscure. MbFe(III) reaction with excess H(2)O(2) in the absence and presence of the nitroxide was studied at pH 5.3-8.1 and 25°C by direct determination of reaction rate constants using rapid-mixing stopped-flow technique, by following H(2)O(2) depletion, O(2) evolution, spectral changes of the heme protein, and the fate of the nitroxide by EPR spectroscopy. The rates of both H(2)O(2) dismutation and heme inactivation processes depend on [MbFe(III)], [H(2)O(2)] and pH. Yet the inactivation stoichiometry is independent of these variables and each MbFe(III) molecule catalyzes the dismutation of 50±10 H(2)O(2) molecules until it is inactivated. The nitroxide catalytically enhances the catalase-like activity of MbFe(III) while protecting the heme against inactivation. The rate-determining step in the absence and presence of the nitroxide is the reduction of MbFe(IV)O by H(2)O(2) and by nitroxide, respectively. The nitroxide effects on H(2)O(2) dismutation catalyzed by MbFe(III) demonstrate that MbFe(IV)O reduction by H(2)O(2) is the rate-determining step of this process. The proposed mechanism, which adequately fits the pro-catalytic and protective effects of the nitroxide, implies the intermediacy of a compound I-H(2)O(2) adduct, which decomposes to a MbFe(IV)O and an inactivated heme at a ratio of 25:1. The effects of nitroxides are instrumental in elucidating the mechanism underlying the catalysis and inactivation routes of heme proteins. Copyright © 2016 Elsevier B.V. All rights reserved.

Nitroxide-Mediated Radical Polymerization of Styrene Initiated from the Surface of Titanium Oxide Nanoparticles

Directory of Open Access Journals (Sweden)

M. Abbasian

2016-01-01

Full Text Available Titanium dioxide (TiO2 nanoparticles, with an average size of about 45 nm, were encapsulated by polystyrene using in situ nitroxide mediated radical polymerization   in the presence of 3-aminopropyl triethoxy silane (APTES as a coupling agent and 2, 2, 6, 6-tetramethylpiperidinyl-1-oxy  as a initiator. First, the initiator for NMRP was covalently bonded onto the surface of Titanium dioxide nanoparticles through our novel method. For this purpose, the surface of TiO2 nanoparticle was treated with 3-aminopropyl triethoxy silane, a silane coupling agent, and then these functionalized nanoparticles was reacted with ±-chloro phenyl acetyl chloride. The chlorine groups were converted to nitroxide mediated groups by coupling with 1-hydroxy-2, 2, 6, 6-tetramethyl piperidine. These modified TiO2 nanoparticles were then dispersed in styrene (St monomers to carry out the in situ free radical polymerization.

Increased Nitroxidative Stress Promotes Mitochondrial Dysfunction in Alcoholic and Nonalcoholic Fatty Liver Disease

Directory of Open Access Journals (Sweden)

Byoung-Joon Song

2013-01-01

Full Text Available Increased nitroxidative stress causes mitochondrial dysfunctions through oxidative modifications of mitochondrial DNA, lipids, and proteins. Persistent mitochondrial dysfunction sensitizes the target cells/organs to other pathological risk factors and thus ultimately contributes to the development of more severe disease states in alcoholic and nonalcoholic fatty liver disease. The incidences of nonalcoholic fatty liver disease continuously increase due to high prevalence of metabolic syndrome including hyperlipidemia, hypercholesterolemia, obesity, insulin resistance, and diabetes. Many mitochondrial proteins including the enzymes involved in fat oxidation and energy supply could be oxidatively modified (including S-nitrosylation/nitration under increased nitroxidative stress and thus inactivated, leading to increased fat accumulation and ATP depletion. To demonstrate the underlying mechanism(s of mitochondrial dysfunction, we employed a redox proteomics approach using biotin-N-maleimide (biotin-NM as a sensitive biotin-switch probe to identify oxidized Cys residues of mitochondrial proteins in the experimental models of alcoholic and acute liver disease. The aims of this paper are to briefly describe the mechanisms, functional consequences, and detection methods of mitochondrial dysfunction. We also describe advantages and limitations of the Cys-targeted redox proteomics method with alternative approaches. Finally, we discuss various applications of this method in studying oxidatively modified mitochondrial proteins in extrahepatic tissues or different subcellular organelles and translational research.

A study of the conformation and stability of nitroxide free radicals

International Nuclear Information System (INIS)

Briere, R.

1969-03-01

The first part of this study is an application of nuclear magnetic resonance to the determination of the sign and magnitude of the long range nuclear-electron spin-spin couplings in the free radical nitroxide derived from piperidine. It has been shown that the coupling constants of the protons γ to the nitrogen atom have a pronounced spatial dependence as do the protons in the β position, a point which has not been brought out by previous investigations. Conformational analysis of these compounds has been carried out by measurement of the effect of temperature on the NMR spectra at 310 MHz. The synthesis of di-t-Bu nitroxide labelled with C 13 in the α-position made possible the unambiguous determination of the corresponding 13 C nuclear-electron spin-spin coupling constant, a parameter which had not previously been measured. The coupling constants measured in the 2,2,6,6-tetramethyl piperidine series could then be attributed to the 13 C atoms in the β-position and their variation related to the conformations of the heterocycles. This constitutes the second part of the work reported here. The final section is devoted to a study of the decomposition of an unstable nitroxide having a hydrogen atom in the p-position. This decomposition is bimolecular and the primary isotope effect shows that the rupture. of the C-H bond is involved. From this one can conclude that a nitroxide is stable when the different groups attached to the nitrogen atom cannot give rise to a decomposition either intra molecularly, if the molecular geometry is suitable, or inter molecularly by dimerisation through attack on a different center of a neighbouring molecule thus leading to a fragmentation or a disproportionation. (author) [fr

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

Energy Technology Data Exchange (ETDEWEB)

Fawzi, Nicolas L. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Fleissner, Mark R. [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Anthis, Nicholas J. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Kalai, Tamas; Hideg, Kalman [University of Pecs, Institute of Organic and Medicinal Chemistry (Hungary); Hubbell, Wayne L., E-mail: hubbellw@jsei.ucla.edu [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Clore, G. Marius, E-mail: mariusc@mail.nih.gov [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States)

2011-09-15

The measurement of {sup 1}H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternative to these flexible labels for PRE studies. When introduced at solvent-exposed {alpha}-helical positions in two model proteins, calmodulin (CaM) and T4 lysozyme (T4L), EPR measurements show that the R1p side chain exhibits dramatically reduced internal motion compared to the commonly used R1 spin label (generated by reacting cysteine with the spin labeling compound often referred to as MTSL). Further, only a single nitroxide position is necessary to account for the PREs arising from CaM S17R1p, while an ensemble comprising multiple conformations is necessary for those observed for CaM S17R1. Together, these observations suggest that the nitroxide adopts a single, fixed position when R1p is placed at solvent-exposed {alpha}-helical positions, greatly simplifying the interpretation of PRE data by removing the need to account for the intrinsic flexibility of the spin label.

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

International Nuclear Information System (INIS)

Fawzi, Nicolas L.; Fleissner, Mark R.; Anthis, Nicholas J.; Kálai, Tamás; Hideg, Kálmán; Hubbell, Wayne L.; Clore, G. Marius

2011-01-01

The measurement of 1 H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternative to these flexible labels for PRE studies. When introduced at solvent-exposed α-helical positions in two model proteins, calmodulin (CaM) and T4 lysozyme (T4L), EPR measurements show that the R1p side chain exhibits dramatically reduced internal motion compared to the commonly used R1 spin label (generated by reacting cysteine with the spin labeling compound often referred to as MTSL). Further, only a single nitroxide position is necessary to account for the PREs arising from CaM S17R1p, while an ensemble comprising multiple conformations is necessary for those observed for CaM S17R1. Together, these observations suggest that the nitroxide adopts a single, fixed position when R1p is placed at solvent-exposed α-helical positions, greatly simplifying the interpretation of PRE data by removing the need to account for the intrinsic flexibility of the spin label.

Distance measurements across randomly distributed nitroxide probes from the temperature dependence of the electron spin phase memory time at 240 GHz

Science.gov (United States)

Edwards, Devin T.; Takahashi, Susumu; Sherwin, Mark S.; Han, Songi

2012-10-01

At 8.5 T, the polarization of an ensemble of electron spins is essentially 100% at 2 K, and decreases to 30% at 20 K. The strong temperature dependence of the electron spin polarization between 2 and 20 K leads to the phenomenon of spin bath quenching: temporal fluctuations of the dipolar magnetic fields associated with the energy-conserving spin "flip-flop" process are quenched as the temperature of the spin bath is lowered to the point of nearly complete spin polarization. This work uses pulsed electron paramagnetic resonance (EPR) at 240 GHz to investigate the effects of spin bath quenching on the phase memory times (TM) of randomly-distributed ensembles of nitroxide molecules below 20 K at 8.5 T. For a given electron spin concentration, a characteristic, dipolar flip-flop rate (W) is extracted by fitting the temperature dependence of TM to a simple model of decoherence driven by the spin flip-flop process. In frozen solutions of 4-Amino-TEMPO, a stable nitroxide radical in a deuterated water-glass, a calibration is used to quantify average spin-spin distances as large as r¯=6.6 nm from the dipolar flip-flop rate. For longer distances, nuclear spin fluctuations, which are not frozen out, begin to dominate over the electron spin flip-flop processes, placing an effective ceiling on this method for nitroxide molecules. For a bulk solution with a three-dimensional distribution of nitroxide molecules at concentration n, we find W∝n∝1/r, which is consistent with magnetic dipolar spin interactions. Alternatively, we observe W∝n for nitroxides tethered to a quasi two-dimensional surface of large (Ø ˜ 200 nm), unilamellar, lipid vesicles, demonstrating that the quantification of spin bath quenching can also be used to discern the geometry of molecular assembly or organization.

Reactions of nitroxide radicals in aqueous solutions exposed to non-thermal plasma: limitations of spin trapping of the plasma induced species

Science.gov (United States)

Gorbanev, Yury; Stehling, Nicola; O'Connell, Deborah; Chechik, Victor

2016-10-01

Low temperature (‘cold’) atmospheric pressure plasmas have gained much attention in recent years due to their biomedical effects achieved through the interactions of plasma-induced species with the biological substrate. Monitoring of the radical species in an aqueous biological milieu is usually performed via electron paramagnetic resonance (EPR) spectroscopy using various nitrone spin traps, which form persistent radical adducts with the short-lived radicals. However, the stability of these nitroxide radical adducts in the plasma-specific environment is not well known. In this work, chemical transformations of nitroxide radicals in aqueous solutions using a model nitroxide 4-oxo-TEMPO were studied using EPR and LC-MS. The kinetics of the nitroxide decay when the solution was exposed to plasma were assessed, and the reactive pathways proposed. The use of different scavengers enabled identification of the types of reactive species which cause the decay, indicating the predominant nitroxide group reduction in oxygen-free plasmas. The 2H adduct of the PBN spin trap (PBN-D) was shown to decay similarly to the model molecule 4-oxo-TEMPO. The decay of the spin adducts in plasma-treated solutions must be considered to avoid rendering the spin trapping results unreliable. In particular, the selectivity of the decay indicated the limitations of the PTIO/PTI nitroxide system in the detection of nitric oxide.

E. P. R. spectroscopic study of nitroxide mono- and bi-radicals

International Nuclear Information System (INIS)

Lemaire, H.

1966-09-01

A nitroxide is a molecule containing the group N-O where the oxygen atom made only one bond instead of the usual two. The main advantage of these radicals is their exceptional stability; this allows the study of well defined chemical structures while varying at will the experimental conditions. Studies by electron paramagnetic resonance of nitroxide mono-radicals have given the principal directions and the principal values of the electron-nitrogen nucleus hyperfine tensor and of the anisotropic g-factor tensor. The results were then related to the electronic structure of radicals. An understanding was obtained of the influence of the solvent on the principal values of the tensors, and the marked differences observed in the broadening of hyperfine lines when the medium become viscous. In the nitroxide biradicals, the hyperfine spectra depends not only on the magnetic interactions relative to each monomer, but also on the magnitude of the exchange interaction between the singlet and the triplet states of the dimer; the biradicals studied here are the first organic compounds which show clearly the influence of this exchange on the hyperfine structure. The two unpaired electrons also interact by a magnetic dipolar interaction: in the intermediate case, this can be used to derive the sign of the exchange interaction if the bi-radical is studied in a liquid crystal. Just as for mono-radicals, the hyperfine spectra of bi-radicals show selective broadening in viscous media, which is caused by an overall motional modulation of the anisotropic tensors. This gives another way to determine the sign of the exchange interaction. (author) [fr

Preparation and physico-chemical study of nitroxide radicals. Isotopic marking with carbon 13 and deuterium

International Nuclear Information System (INIS)

Chapelet-Letourneux, G.

1969-01-01

N-t-butyl-N-phenyl nitroxide is obtained by: a) action of t-butyl-magnesium chloride on nitrobenzene, or of phenyl-magnesium bromide on nitro-t-butane, b) oxidation of N-t-butyl-N-phenylhydroxylamine, c) oxidation of N-t-butylaniline. In these latter two cases, it has been possible to isolate the pure radical and to study it using UV, IR and EPR. It decomposes to give N-t-butylaniline and the N-oxide of N-t-butyl-p-quinon-imine. The action of peracids such as p-nitro-perbenzoic or m-chloro-perbenzoic acids on amines or hydroxylamines leads to the formation of stable or unstable nitroxide radicals easily observable by EPR. Finally, with a view to obtaining definite values for the coupling between the free electron of a nitroxide and carbon 13, the preparation of such radicals marked with 13 C in the α or β position of the nitroxide function has been carried out. The coupling with an α carbon 13 is negative and does not appear to vary with the spin density on the nitrogen. The interaction with the p nuclei of the nitrogen depends on the nature of the substituents: the two benzyl protons have a hyperfine splitting a H which is always less than that of the ethyl. On the other hand, the 13 C coupling is greater in the first case. The usually adopted conformations for the compounds having the carbonyl group cannot account for the observed values of the β couplings. (author) [fr

The LEGO toolbox: Supramolecular building blocks by nitroxide-mediated controlled radical polymerization

NARCIS (Netherlands)

Lohmeijer, B.G.G.; Schubert, U.S.

2005-01-01

A terpyridine-functionalized alkoxyamine unimolecular initiator was used for the nitroxide-mediated controlled living radical polymerization of n-butylacrylate, N,N-dimethylacrylamide, 4-vinylpyridine, 2-vinylpyridine, and isoprene. For the former three monomers, the kinetics were studied. All

Nitroxide-mediated homopolymerization and copolymerization of 2-vinylpyridine with styrene

Czech Academy of Sciences Publication Activity Database

Lokaj, Jan; Holler, Petr

2001-01-01

Roč. 80, č. 11 (2001), s. 2024-2030 ISSN 0021-8995 R&D Projects: GA ČR GA203/99/0572; GA AV ČR KSK2050602 Institutional research plan: CEZ:AV0Z4050913 Keywords : nitroxide-mediated polymerization * pseudoliving mechanism * 2-vinylpyridine polymers Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.992, year: 2001

Intraesophageal administratio (JP4-039) and p53/MDM2/MDM4 Inhibitor (BEB55) ameliorates radiation esophagitisn of GS-Nitroxide

NARCIS (Netherlands)

Kim, H.; Bernard, M.; Epperly, M.W.; Shen, H.; Dixon, T.M.; Amoscato, A.A.; Doemling, A.S.; Li, S.; Gao, X.; Wipf, P.

2011-01-01

Purpose/Objective(s): To evaluate the esophageal radiation dose modification properties of the GS-nitroxide (JP4-039) and the p53/MDM2/MDM4 inhibitor (BEB55). Materials/Methods: Esophagitis is a significant toxicity of radiation therapy of thoracic cancers. We evaluated radiation dose modification

Tritiation and Stability Measurements of Nitroxide for Betavoltaic Cells

Science.gov (United States)

2016-09-01

source compounds include low beta-flux power, intrinsic isotope leakage , and beta self-absorption. The figure of merit for a tritiated compound is...graphane, fully hydrogenated graphene. Graphane is not reactive in water or air; it has theoretical higher mechanical and thermal strength than graphene...bonded to the side group of the nitroxide radical TEMPO 6-membered ring. The ester-cleaved product is detectable and is used to assess the specific

Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves

Energy Technology Data Exchange (ETDEWEB)

Thurber, Kent R., E-mail: thurberk@niddk.nih.gov; Tycko, Robert [Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520 (United States)

2014-05-14

We report solid state {sup 13}C and {sup 1}H nuclear magnetic resonance (NMR) experiments with magic-angle spinning (MAS) on frozen solutions containing nitroxide-based paramagnetic dopants that indicate significant perturbations of nuclear spin polarizations without microwave irradiation. At temperatures near 25 K, {sup 1}H and cross-polarized {sup 13}C NMR signals from {sup 15}N,{sup 13}C-labeled L-alanine in trinitroxide-doped glycerol/water are reduced by factors as large as six compared to signals from samples without nitroxide doping. Without MAS or at temperatures near 100 K, differences between signals with and without nitroxide doping are much smaller. We attribute most of the reduction of NMR signals under MAS near 25 K to nuclear spin depolarization through the cross-effect dynamic nuclear polarization mechanism, in which three-spin flips drive nuclear polarizations toward equilibrium with spin polarization differences between electron pairs. When T{sub 1e} is sufficiently long relative to the MAS rotation period, the distribution of electron spin polarization across the nitroxide electron paramagnetic resonance lineshape can be very different from the corresponding distribution in a static sample at thermal equilibrium, leading to the observed effects. We describe three-spin and 3000-spin calculations that qualitatively reproduce the experimental observations.

Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves

International Nuclear Information System (INIS)

Thurber, Kent R.; Tycko, Robert

2014-01-01

We report solid state 13 C and 1 H nuclear magnetic resonance (NMR) experiments with magic-angle spinning (MAS) on frozen solutions containing nitroxide-based paramagnetic dopants that indicate significant perturbations of nuclear spin polarizations without microwave irradiation. At temperatures near 25 K, 1 H and cross-polarized 13 C NMR signals from 15 N, 13 C-labeled L-alanine in trinitroxide-doped glycerol/water are reduced by factors as large as six compared to signals from samples without nitroxide doping. Without MAS or at temperatures near 100 K, differences between signals with and without nitroxide doping are much smaller. We attribute most of the reduction of NMR signals under MAS near 25 K to nuclear spin depolarization through the cross-effect dynamic nuclear polarization mechanism, in which three-spin flips drive nuclear polarizations toward equilibrium with spin polarization differences between electron pairs. When T 1e is sufficiently long relative to the MAS rotation period, the distribution of electron spin polarization across the nitroxide electron paramagnetic resonance lineshape can be very different from the corresponding distribution in a static sample at thermal equilibrium, leading to the observed effects. We describe three-spin and 3000-spin calculations that qualitatively reproduce the experimental observations

Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves.

Science.gov (United States)

Thurber, Kent R; Tycko, Robert

2014-05-14

We report solid state (13)C and (1)H nuclear magnetic resonance (NMR) experiments with magic-angle spinning (MAS) on frozen solutions containing nitroxide-based paramagnetic dopants that indicate significant perturbations of nuclear spin polarizations without microwave irradiation. At temperatures near 25 K, (1)H and cross-polarized (13)C NMR signals from (15)N,(13)C-labeled L-alanine in trinitroxide-doped glycerol/water are reduced by factors as large as six compared to signals from samples without nitroxide doping. Without MAS or at temperatures near 100 K, differences between signals with and without nitroxide doping are much smaller. We attribute most of the reduction of NMR signals under MAS near 25 K to nuclear spin depolarization through the cross-effect dynamic nuclear polarization mechanism, in which three-spin flips drive nuclear polarizations toward equilibrium with spin polarization differences between electron pairs. When T1e is sufficiently long relative to the MAS rotation period, the distribution of electron spin polarization across the nitroxide electron paramagnetic resonance lineshape can be very different from the corresponding distribution in a static sample at thermal equilibrium, leading to the observed effects. We describe three-spin and 3000-spin calculations that qualitatively reproduce the experimental observations.

Cross relaxation in nitroxide spin labels

DEFF Research Database (Denmark)

Marsh, Derek

2016-01-01

Cross relaxation, and mI-dependence of the intrinsic electron spin-lattice relaxation rate We, are incorporated explicitly into the rate equations for the electron-spin population differences that govern the saturation behaviour of 14N- and 15N-nitroxide spin labels. Both prove important in spin......-label EPR and ELDOR, particularly for saturation recovery studies. Neither for saturation recovery, nor for CW-saturation EPR and CW-ELDOR, can cross relaxation be described simply by increasing the value of We, the intrinsic spin-lattice relaxation rate. Independence of the saturation recovery rates from...... the hyperfine line pumped or observed follows directly from solution of the rate equations including cross relaxation, even when the intrinsic spin-lattice relaxation rate We is mI-dependent....

New Amino-Acid-Based β-Phosphorylated Nitroxides for Probing Acidic pH in Biological Systems by EPR Spectroscopy.

Science.gov (United States)

Thétiot-Laurent, Sophie; Gosset, Gaëlle; Clément, Jean-Louis; Cassien, Mathieu; Mercier, Anne; Siri, Didier; Gaudel-Siri, Anouk; Rockenbauer, Antal; Culcasi, Marcel; Pietri, Sylvia

2017-02-01

There is increasing interest in measuring pH in biological samples by using nitroxides with pH-dependent electron paramagnetic resonance (EPR) spectra. Aiming to improve the spectral sensitivity (Δa X ) of these probes (i.e., the difference between the EPR hyperfine splitting (hfs) in their protonated and unprotonated forms), we characterized a series of novel linear α-carboxy, α'-diethoxyphosphoryl nitroxides constructed on an amino acid core and featuring an (α or α')-C-H bond. In buffer, the three main hfs (a N , a H , and a P ) of their EPR spectra vary reversibly with pH and, from a P or a H titration curves, a two- to fourfold increase in sensitivity was achieved compared to reference imidazoline or imidazolidine nitroxides. The crystallized carboxylate 10 b (pK a ≈3.6), which demonstrated low cytotoxicity and good resistance to bioreduction, was applied to probe stomach acidity in rats. The results pave the way to a novel generation of highly sensitive EPR pH markers. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nitroxide-mediated controlled radical polymerisation: towards control of molar mass Controlled Radical Polymerisation

NARCIS (Netherlands)

Bon, S.A.F.; Bergman, F.A.C.; Es, van J.J.G.S.; Klumperman, B.; German, A.L.; Matyjaszewski, K.

1998-01-01

The mechanism of the TEMPO-mediated controlled radical polymerization of styrene in bulk is discussed. It is shown that the isotropic correlation time (tc) of a nitroxide can be used as a measure of the diffusive rate coefficient of trapping (ketD). A general empirical relationship for the density

Anaerobic Nitroxide-Catalyzed Oxidation of Alcohols Using the NO+/NO center dot Redox Pair

Czech Academy of Sciences Publication Activity Database

Holan, Martin; Jahn, Ullrich

2014-01-01

Roč. 16, č. 1 (2014), s. 58-61 ISSN 1523-7060 R&D Projects: GA ČR GA13-40188S Institutional support: RVO:61388963 Keywords : oxidation * nitroxides * aldehydes * alcohols * ketones * alkyl nitrites Subject RIV: CC - Organic Chemistry Impact factor: 6.364, year: 2014

In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques

Science.gov (United States)

Bačić, Goran; Pavićević, Aleksandra; Peyrot, Fabienne

2015-01-01

Free radicals, particularly reactive oxygen species (ROS), are involved in various pathologies, injuries related to radiation, ischemia-reperfusion or ageing. Unfortunately, it is virtually impossible to directly detect free radicals in vivo, but the redox status of the whole organism or particular organ can be studied in vivo by using magnetic resonance techniques (EPR and MRI) and paramagnetic stable free radicals – nitroxides. Here we review results obtained in vivo following the pharmacokinetics of nitroxides on experimental animals (and a few in humans) under various conditions. The focus was on conditions where the redox status has been altered by induced diseases or harmful agents, clearly demonstrating that various EPR/MRI/nitroxide combinations can reliably detect metabolically induced changes in the redox status of organs. These findings can improve our understanding of oxidative stress and provide a basis for studying the effectiveness of interventions aimed to modulate oxidative stress. Also, we anticipate that the in vivo EPR/MRI approach in studying the redox status can play a vital role in the clinical management of various pathologies in the years to come providing the development of adequate equipment and probes. PMID:26827126

In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques

Directory of Open Access Journals (Sweden)

Goran Bačić

2016-08-01

Full Text Available Free radicals, particularly reactive oxygen species (ROS, are involved in various pathologies, injuries related to radiation, ischemia-reperfusion or ageing. Unfortunately, it is virtually impossible to directly detect free radicals in vivo, but the redox status of the whole organism or particular organ can be studied in vivo by using magnetic resonance techniques (EPR and MRI and paramagnetic stable free radicals – nitroxides. Here we review results obtained in vivo following the pharmacokinetics of nitroxides on experimental animals (and a few in humans under various conditions. The focus was on conditions where the redox status has been altered by induced diseases or harmful agents, clearly demonstrating that various EPR/MRI/nitroxide combinations can reliably detect metabolically induced changes in the redox status of organs. These findings can improve our understanding of oxidative stress and provide a basis for studying the effectiveness of interventions aimed to modulate oxidative stress. Also, we anticipate that the in vivo EPR/MRI approach in studying the redox status can play a vital role in the clinical management of various pathologies in the years to come providing the development of adequate equipment and probes.

Photostability enhancement of the pentacene derivative having two nitronyl nitroxide radical substituents.

Science.gov (United States)

Shimizu, Akihiro; Ito, Akitaka; Teki, Yoshio

2016-02-18

Pentacene derivatives possessing nitronyl nitroxide radical substituents (1a and 1b) were synthesized, and their photochemical properties were evaluated. 1a with two radical substituents showed a remarkable enhancement of photostability compared with pentacene, 6,13-bis(triisopropylsilylethynyl)pentacene and the monoradical, 1b. This is understood due to the presence of the multiple deactivation pathways in the photoexcited states.

Real-time quantification of oxidative stress and the protective effect of nitroxide antioxidants.

Science.gov (United States)

Rayner, Cassie L; Bottle, Steven E; Gole, Glen A; Ward, Micheal S; Barnett, Nigel L

2016-01-01

Nitroxides have been exploited as profluorescent probes for the detection of oxidative stress. In addition, they deliver potent antioxidant action and attenuate reactive oxygen species (ROS) in various models of oxidative stress, with these results ascribed to superoxide dismutase or redox and radical-scavenging actions. Our laboratory has developed a range of novel, biostable, isoindoline nitroxide-based antioxidants, DCTEIO and CTMIO. In this study we compared the efficiency of these novel compounds as antioxidant therapies in reducing ROS both in vivo (rat model) and in vitro (661W photoreceptor cells), with the established antioxidant resveratrol. By assessing changes in fluorescence intensity of a unique redox-responsive probe in the rat retina in vivo, we evaluated the ability of antioxidant therapy to (1) ameliorate ROS production and (2) reverse the accumulation of ROS after complete, acute ischemia followed by reperfusion (I/R). I/R injury induced a marked decrease in fluorescence intensity over 60 min of reperfusion, which was successfully ameliorated with each of the antioxidants. DCTEIO and CTMIO reversed the accumulation of ROS when administered intraocularly post ischemic insult, whereas, the effect of resveratrol was not significant. We also investigated our novel agents' capacity to prevent ROS-mediated metabolic dysfunction in the 661W photoreceptor cell line. Cellular stress induced by the oxidant, tert-butyl hydroperoxide, resulted in a loss of spare mitochondrial respiratory capacity (SMRC) and in the extracellular acidification rate in 661W cells. DCTEIO antioxidant administration successfully reduced the loss of SMRC. Together, these findings show we can quantify dynamic changes in cellular oxidative status in vivo and suggest that nitroxide-based antioxidants may provide greater protection against oxidative stress than the current state-of-the-art antioxidant treatments for ROS-mediated diseases. Copyright © 2015 Elsevier Ltd. All rights

Silica-Polystyrene Nanocomposite Particles Synthesized by Nitroxide-Mediated Polymerization and Their Encapsulation through Miniemulsion Polymerization

Directory of Open Access Journals (Sweden)

Bérangère Bailly

2006-01-01

Full Text Available Polystyrene (PS chains with molecular weights comprised between 8000 and 64000 g⋅mol-1 and narrow polydispersities were grown from the surface of silica nanoparticles (Aerosil A200 fumed silica and Stöber silica, resp. through nitroxide-mediated polymerization (NMP. Alkoxyamine initiators based on N-tert-butyl-1-diethylphosphono-2,2-dimethylpropyl nitroxide (DEPN and carrying a terminal functional group have been synthesized in situ and grafted to the silica surface. The resulting grafted alkoxyamines have been employed to initiate the growth of polystyrene chains from the inorganic surface. The maximum grafting density of the surface-tethered PS chains was estimated and seemed to be limited by initiator confinement at the interface. Then, the PS-grafted Stöber silica nanoparticles were entrapped inside latex particles via miniemulsion polymerization. Transmission electron microscopy indicated the successful formation of silica-polystyrene core-shell particles.

Syntheses and study of pyrrolidinic nitroxide free radicals. Preparation of a nitroxide-type stable bi-radical; Synthese et etudes de radicaux libres nitroxydes pyrrolidiniques. Preparation d'un biradical stable du type nitroxyde

Energy Technology Data Exchange (ETDEWEB)

Dupeyre, R M [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires, Laboratoire de chimie organique physique

1967-12-01

Syntheses and study of pyrrolidinic nitroxide free radicals: These radicals are obtained by oxidation, with hydrogen peroxide, of pyrrolidinic amines prepared from triacetonamine by ring contraction. The U. V,, I. R, and E.P.R. spectral characteristics have been determined. The oxidation of these amines with hydrogen peroxide has led also to rupture of the pentagonal ring; some of the decomposition products have been identified. The high chemical stability of the nitroxide group has made it possible to synthesize and study a stable bi-radical. (author) [French] Syntheses et etudes de radicaux libres nitroxydes pyrrolidiniques: Ces radicaux sont obtenus par oxydation l'eau oxygenee d'amines pyrrolidiniques preparees a partir de la triacetonamine par contraction de cycle. Les caracteristiques spectroscopiques ultra-violettes, infra-rouge et resonance paramagnetique sont determinees. Cependant, 1'oxydation de ces amines a l'eau oxygenee a entraine la coupure du cycle pentagonal et identification de certaines substances de decomposition obtenues. La grande stabilite chimique de groupement nitroxyde a permis la synthese et l'etude d'un biradical stable. (auteur)

Magnetic Properties of linear chain compounds formed by lanthanide (III) ions and nitronyl-nitroxide radicals

Energy Technology Data Exchange (ETDEWEB)

Benelli, C.; Caneschi, A.; Gatteschi, D.; Pardi, L. (Florence Univ. (IT)); Rey, P. (CEA Centre d' Etudes Nucleaires de Grenoble, 38 (FR). Dept. de Recherche Fondamentale)

1988-12-01

The magnetic properties of novel linear chain compounds containing lanthanide (III) ions (gadolinium, europium) coupled to stable nitronyl-nitroxide radicals are reported. The metal ions and the radicals are regularly alternating along the chain. The magnetic behaviors appears to be dominated by antiferromagnetic interactions between the radicals.

Magnetic Properties of linear chain compounds formed by lanthanide (III) ions and nitronyl-nitroxide radicals

International Nuclear Information System (INIS)

Benelli, C.; Caneschi, A.; Gatteschi, D.; Pardi, L.; Rey, P.

1988-01-01

The magnetic properties of novel linear chain compounds containing lanthanide (III) ions (gadolinium, europium) coupled to stable nitronyl-nitroxide radicals are reported. The metal ions and the radicals are regularly alternating along the chain. The magnetic behaviors appears to be dominated by antiferromagnetic interactions between the radicals

Interpretation of cw-ESR spectra of p-methyl-thio-phenyl-nitronyl nitroxide in a nematic liquid crystalline phase.

Science.gov (United States)

Collauto, Alberto; Zerbetto, Mirco; Brustolon, Marina; Polimeno, Antonino; Caneschi, Andrea; Gatteschi, Dante

2012-03-07

In this paper we report on the characterization by continuous wave electron spin resonance spectroscopy (cw-ESR) of a nitronyl nitroxide radical in a nematic phase. A detailed analysis is performed by exploiting an innovative modeling strategy alternative to the usual spectral simulation approach: most of the molecular parameters needed to calculate the spectrum are evaluated a priori and the ESR spectrum is obtained by direct application of the stochastic Liouville equation. Allowing a limited set of fitting parameters it is possible to reproduce satisfactorily ESR spectra in the temperature range 260 K-340 K including the nematic-to-isotropic phase transition (325.1 K). Our results open the way to a more quantitative understanding of the ordering and mobility of nitronyl nitroxide radicals in nanostructured environments.

Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol

International Nuclear Information System (INIS)

Mitchell, J.B.; DeGraff, W.; Kaufman, D.; Krishna, M.C.; Samuni, A.; Finkelstein, E.; Ahn, M.S.; Hahn, S.M.; Gamson, J.; Russo, A.

1991-01-01

Stable nitroxide radicals have been previously shown to function as superoxide dismutase (SOD)2 mimics and to protect mammalian cells against superoxide and hydrogen peroxide-mediated oxidative stress. These unique characteristics suggested that nitroxides, such as 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol), might protect mammalian cells against ionizing radiation. Treating Chinese hamster cells under aerobic conditions with 5, 10, 50, and 100 mM Tempol 10 min prior to X-rays resulted in radiation protection factors of 1.25, 1.30, 2.1, and 2.5, respectively. However, the reduced form of Tempol afforded no protection. Tempol treatment under hypoxic conditions did not provide radioprotection. Aerobic X-ray protection by Tempol could not be attributed to the induction of intracellular hypoxia, increase in intracellular glutathione, or induction of intracellular SOD mRNA. Tempol thus represents a new class of non-thiol-containing radiation protectors, which may be useful in elucidating the mechanism(s) of radiation-induced cellular damage and may have broad applications in protecting against oxidative stress

Nitroxide stable radicals interacting as Lewis bases in hydrogen bonds: A search in the Cambridge structural data base for intermolecular contacts

Science.gov (United States)

Alkorta, Ibon; Elguero, José; Elguero, Eric

2017-11-01

1125 X-ray structures of nitroxide free radicals presenting intermolecular hydrogen bonds have been reported in the Cambridge Structural Database. We will report in this paper a qualitative and quantitative analysis of these bonds. The observation in some plots of an excluded region was statistically analyzed using convex hull and kernel smooting methodologies. A theoretical study at the MP2 level with different basis has been carried out indicating that the nitronyl nitroxide radicals (five electrons) lie just in between nitroso compounds (four electrons) and amine N-oxides (six electrons) as far as hydrogen-bond basicity is concerned.

High-throughput optimization of nitroxide mediated radical polymerizations as basis for the synthesis of temperature-responsive copolymers

NARCIS (Netherlands)

Hoogenboom, R.; Becer, C.R.; Eggenhuisen, T.M.; Schubert, U.S.

2008-01-01

The development of controlled radical polymn. techniques, namely atom transfer radical polymn. (ATRP), reversible addn. fragmentation transfer (RAFT) and nitroxide mediated radical polymn. (NMP), have opened up unprecedented possibilities for the synthesis of well-defined macromol. architectures

In situ NMR and modeling studies of nitroxide mediated copolymerization of styrene and n-butyl acrylate

NARCIS (Netherlands)

Hlalele, L.; Klumperman, L.

2011-01-01

The combination of in situ1H NMR and in situ31P NMR was used to study the nitroxide mediated copolymerization of styrene and n-butyl acrylate. The alkoxyamine MAMA-DEPN was employed to initiate and mediate the copolymerization. The nature of the ultimate/terminal monomer units of dormant polymer

A study of nitroxide polyradical/activated carbon composite as the positive electrode material for electrochemical hybrid capacitor

Energy Technology Data Exchange (ETDEWEB)

Li, Hui-qiao; Zou, Ying; Xia, Yong-yao [Chemistry Department and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433 (China)

2007-01-01

We present a new concept of the hybrid electrochemical capacitor technology in which a poly(2,2,6,6-tetramethylpiperidinyloxy methacrylate) nitroxide polyradical/activated carbon composite (PTMA-AC) is used as the positive electrode material and activated carbon is used as the negative electrode material. On the positive electrode, both reversible reduction and oxidation of nitroxide polyradical and non-faradic ion sorption/de-sorption of activated carbon are involved during charge and discharge process. The capacity of the composite electrode is 30% larger than that of the pure activated carbon electrode. A hybrid capacitor fabricated by the PTMA-AC composite positive electrode and the activated carbon negative electrode shows a good cycling life, it can be charged/discharged for over 1000 cycles with slight capacity loss. The hybrid capacitor also has a good rate capability, it maintains 80% of the initial capacity even at the high discharge current of up to 20C. (author)

Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress.

Science.gov (United States)

Abdelmegeed, Mohamed A; Choi, Youngshim; Ha, Seung-Kwoon; Song, Byoung-Joon

2017-11-01

The aim of this study was to investigate the role of cytochrome P450-2E1 (CYP2E1) in aging-dependent kidney damage since it is poorly understood. Young (7 weeks) and aged female (16-17 months old) wild-type (WT) and Cyp2e1-null mice were used. Kidney histology showed that aged WT mice exhibited typical signs of kidney aging such as cell vacuolation, inflammatory cell infiltration, cellular apoptosis, glomerulonephropathy, and fibrosis, along with significantly elevated levels of renal TNF-α and serum creatinine than all other groups. Furthermore, the highest levels of renal hydrogen peroxide, protein carbonylation and nitration were observed in aged WT mice. These increases in the aged WT mice were accompanied by increased levels of iNOS and mitochondrial nitroxidative stress through altered amounts and activities of the mitochondrial complex proteins and significantly reduced levels of the antioxidant glutathione (GSH). In contrast, the aged Cyp2e1-null mice exhibited significantly higher antioxidant capacity with elevated heme oxygenase-1 and catalase activities compared to all other groups, while maintaining normal GSH levels with significantly less mitochondrial nitroxidative stress compared to the aged WT mice. Thus, CYP2E1 is important in causing aging-related kidney damage most likely through increasing nitroxidative stress and that CYP2E1 could be a potential target in preventing aging-related kidney diseases. Published by Elsevier Ltd.

Molecular order and T1-relaxation, cross-relaxation in nitroxide spin labels

Science.gov (United States)

Marsh, Derek

2018-05-01

Interpretation of saturation-recovery EPR experiments on nitroxide spin labels whose angular rotation is restricted by the orienting potential of the environment (e.g., membranes) currently concentrates on the influence of rotational rates and not of molecular order. Here, I consider the dependence on molecular ordering of contributions to the rates of electron spin-lattice relaxation and cross relaxation from modulation of N-hyperfine and Zeeman anisotropies. These are determined by the averages and , where θ is the angle between the nitroxide z-axis and the static magnetic field, which in turn depends on the angles that these two directions make with the director of uniaxial ordering. For saturation-recovery EPR at 9 GHz, the recovery rate constant is predicted to decrease with increasing order for the magnetic field oriented parallel to the director, and to increase slightly for the perpendicular field orientation. The latter situation corresponds to the usual experimental protocol and is consistent with the dependence on chain-labelling position in lipid bilayer membranes. An altered dependence on order parameter is predicted for saturation-recovery EPR at high field (94 GHz) that is not entirely consistent with observation. Comparisons with experiment are complicated by contributions from slow-motional components, and an unexplained background recovery rate that most probably is independent of order parameter. In general, this analysis supports the interpretation that recovery rates are determined principally by rotational diffusion rates, but experiments at other spectral positions/field orientations could increase the sensitivity to order parameter.

Spatial profiling of degradation processes in hindered-amine-stabilized polymers by electron spin resonance imaging of nitroxides

Czech Academy of Sciences Publication Activity Database

Marek, Antonín; Kaprálková, Ludmila; Pfleger, Jiří; Pospíšil, Jan; Pilař, Jan

2005-01-01

Roč. 99, S (2005), s. 195-198 ISSN 0009-2770. [Meeting on Chemistry and Life /3./. Brno, 20.9.2005-22.9.2005] Institutional research plan: CEZ:AV0Z40500505 Keywords : polymer degradation * nitroxides * electron spin resonance imaging Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.445, year: 2005

Synthesis, autoxidation and photooxidation of hindered pyrrole derivatives. Hindered pyrrolic nitroxide radicals; Synthese, autoxydation et photoxidation de pyrroles encombres radicaux nitroxydes pyrroliques encombres

Energy Technology Data Exchange (ETDEWEB)

Ramasseul, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-07-01

2,5-di-t-butyl and 2,3,5-tri-t-butyl pyrrole are prepared from pinacoline and their structure is confirmed by comparison with 2,5-di-t-butyl furan and thiophene (I.R., U.V. and N.M.R. {sup 13}C satellites observation giving J{sub 13{sub C-H}} and J{sub H{sub 3}-H{sub 4}}). The sensitized photooxidation of these hindered pyrroles gives corresponding hydroperoxides which most likely structure is determined using physical and chemical methods. Oxidation of 2,5-di-t-butyl and 2,3,5-tri-t-butyl pyrrole by hydrogen peroxide in presence of inorganic per-acid of by p-nitro-perbenzoic acid does not give the pyrrolic nitroxides in contrast with secondary amines. Some N-hydroxypyrroles are then prepared from pinacoline and ethyl pivaloyl-acetate. Their oxidation by lead dioxide gives the corresponding pyrrolic nitroxides. 2,5-di-t-butyl 3,4-di-ethoxycarbonyl pyrryl 1-oxy is isolated and studied spectroscopically (visible and U.V., E.P.R.). In marked contrast with ordinary nitroxides it does not show solvent effect. It can be compared with 2,4-di-t-butyl cyclopentadienone, a carbon analog. For both, the long wave length transition does not show the usual n - {pi}* behaviour; that is confirmed by E.P.R. Using Huckel method for pyrrolic nitroxide skeleton, it is possible to have a good interpretation of experimental data. (author) [French] Les di-t-butyl 2,5 et tri-t-butyl-2,3,5 pyrrole sont synthetises a partir de la pinacoline et leur structure confirmee par comparaison avec les di-t-butyl-2,5 furanne et thiophene (I.R., U.V. et R.M.N.: observation des satellites {sup 13}C conduisant a la mesure des J{sub 13{sub C-H}} et J{sub H{sub 3}{sub -H{sub 4}}). La photoxydation sensibilisee de ces pyrroles encombres conduit aux hydroperoxydes correspondants dont la structure la plus probable est determinee par les methodes physicochimiques. L'oxydation des di-t-butyl-2,5 et tri-t-butyl-2,3,5 pyrrole par l'eau oxygenee en presence de peracide mineral ou par l'acide p

A perspective on slow-relaxing molecular magnets built from rare-earths and nitronyl-nitroxide building blocks (invited)

Science.gov (United States)

Bogani, Lapo

2011-04-01

We offer a perspective, accessible to both chemists and physicists, of recent developments in the synthesis and characterization of molecular magnetic materials based on rare-earths and nitronyl-nitroxide radicals. We show both the rationale of the synthetic strategies and the observed behaviors. We highlight the relevance of these findings for synthetic chemists, material scientists, and physicists.

Nitroxides are more efficient inhibitors of oxidative damage to calf skin collagen than antioxidant vitamins.

Science.gov (United States)

Venditti, Elisabetta; Scirè, Andrea; Tanfani, Fabio; Greci, Lucedio; Damiani, Elisabetta

2008-01-01

Reactive oxygen species generated upon UV-A exposure appear to play a major role in dermal connective tissue transformations including degradation of skin collagen. Here we investigate on oxidative damage to collagen achieved by exposure to (i) UV-A irradiation and to (ii) AAPH-derived radicals and on its possible prevention using synthetic and natural antioxidants. Oxidative damage was identified through SDS-PAGE, circular dichroism spectroscopy and quantification of protein carbonyl residues. Collagen (2 mg/ml) exposed to UV-A and to AAPH-derived radicals was degraded in a time- and dose-dependent manner. Upon UV-A exposure, maximum damage was observable at 730 kJ/m2 UV-A, found to be equivalent to roughly 2 h of sunshine, while exposure to 5 mM AAPH for 2 h at 50 degrees C lead to maximum collagen degradation. In both cases, dose-dependent protection was achieved by incubation with muM concentrations of nitroxide radicals, where the extent of protection was shown to be dictated by their structural differences whereas the vitamins E and C proved less efficient inhibitors of collagen damage. These results suggest that nitroxide radicals may be able to prevent oxidative injury to dermal tissues in vivo alternatively to commonly used natural antioxidants.

Controlled and selective placement of boron subphthalocyanines on either chain end of polymers synthesized by nitroxide mediated polymerization

Directory of Open Access Journals (Sweden)

Benoît H. Lessard

2015-10-01

Full Text Available In previous studies, we synthesized the first organic light emitting diode (OLED using boron subphthalocyanines (BsubPcs based polymers. When designing new polymer materials for organic electronic applications such as OLEDs or organic photovoltaic (OPV devices it is important to consider not only the contribution of each monomer but also the polymer chain ends. In this paper we establish a post-polymerization strategy to couple BsubPcs onto either the α- or the ω-chain end using chemically selective BsubPc derivatives. We outline how the chain ends of two representative polymers, poly(styrene (PS and poly(n-butylacrylate (BA, synthesized by nitroxide mediated polymerization (NMP, using BlocBuilder-MA as the initiating species, can be chemically modified by the incorporation of BsubPc chromophores. The addition of the BsubPc chromophore was confirmed through the use of a photodiode array detector (PDA connected in-line with a gel permeation chromatography (GPC setup. These findings represent the first reported method for the controlled and selective placement of a BsubPc chromophores on either end of a polymer produced by NMP. This strategy will therefore be utilized to make next generation BsubPc polymers for OLEDs and OPV devices. The extremely high molar extinction coefficient of BsubPc also make these polymers ideally suited for dye-labelling of polymers.

Conduction mechanism of nitronyl-nitroxide molecular magnetic compounds

Science.gov (United States)

Dotti, N.; Heintze, E.; Slota, M.; Hübner, R.; Wang, F.; Nuss, J.; Dressel, M.; Bogani, L.

2016-04-01

We investigate the conduction mechanisms of nitronyl-nitroxide (NIT) molecular radicals, as useful for the creation of nanoscopic molecular spintronic devices, finding that it does not correspond to standard Mott behavior, as previously postulated. We provide a complete investigation using transport measurements, low-energy, sub-THz spectroscopy and introducing differently substituted phenyl appendages. We show that a nontrivial surface-charge-limited regime is present in addition to the standard low-voltage Ohmic conductance. Scaling analysis allows one to determine all the main transport parameters for the compounds and highlights the presence of charge-trapping effects. Comparison among the different compounds shows the relevance of intermolecular stacking between the aromatic ring of the phenyl appendix and the NIT motif in the creation of useful electron transport channels. The importance of intermolecular pathways is further highlighted by electronic structure calculations, which clarify the nature of the electronic channels and their effect on the Mott character of the compounds.

Ability of nitrones of various structures to control the radical polymerization of styrene mediated by in situ formed nitroxides.

NARCIS (Netherlands)

Sciannamea, V.; Guerrero-Sanchez, C.A.; Schubert, U.S.; Catala, J.-M.; Jerome, R.; Detrembleur, C.

2005-01-01

The ability of several nitrones to control the radical polymerization of styrene at 110 °C has been investigated by high-throughput experimentation. The nitrone/free radical initiator pair dictates the structure of the nitroxide and the alkoxyamine formed in situ, which determines the position of

Synthesis and quaternization of nitroxide-terminated poly(4-vinylpyridine-co-acrylonitrile) macroinitiators and related diblock copolymers

Czech Academy of Sciences Publication Activity Database

Poláková, Lenka; Lokaj, Jan; Holler, Petr; Starovoytova, Larisa; Pekárek, Michal; Štěpánek, Petr

-, 065 (2010), s. 1-10 ISSN 1618-7229 R&D Projects: GA ČR GESON/06/E005; GA ČR GA203/07/0659 Institutional research plan: CEZ:AV0Z40500505 Keywords : 4-vinylpyridine-acrylonitrile copolymers * block copolymers * nitroxide-mediated radical polymerization Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.574, year: 2010 http://www.e-polymers.org/journal/papers/lpolakova_240710.pdf

Synthesis of diblock copolymers comprising poly(2-vinylpyridine-co-acrylonitrile) and polystyrene blocks by nitroxide-mediated radical polymerization

Czech Academy of Sciences Publication Activity Database

Lokaj, Jan; Poláková, Lenka; Holler, Petr; Starovoytova, Larisa; Štěpánek, Petr; Diat, O.

2007-01-01

Roč. 105, č. 3 (2007), s. 1616-1622 ISSN 0021-8995 R&D Projects: GA ČR GESON/03/E001 Institutional research plan: CEZ:AV0Z40500505 Keywords : 2-vinylpyridine-acrylonitrile copolymers * nitroxide-mediated radical copolymerization * chain extension Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.008, year: 2007

Studies of a nitroxide radical by EPR in monocrystal: interaction of protons and electronic relaxation

International Nuclear Information System (INIS)

Alonso, A.

1986-01-01

The ESR spectra of a nitroxide radical, 4-hydroxi-2,2,6,6-tetramethylpiperidine-1-oxyl (TANOL II), introduced as impurity in a diamagnetic host, 4-hydroxi-2,6,6-tetramethylpiperedine (I), were investigated. The use of deuterated radical, 4-hydroxi-2,2,6,6 tetramethylpiperidine-d sub(17) -1, oxyl (PD-TANOL, III) improved the resolution of ESR spectra for most of orientations of magnetic field. The proton interqactions in the neighbourhood of magnetic group N-O were studied and superpyresfine tensors for two strongly coupled protons were determined. In order to study the influence of protons on electronic relaxation of radicals, the relaxation times T sub(1) and T sub(2) were estimated in the temperature range-160 sup(0)C - 25 sup(0)C for several orientations, and comparing data for protonated and deuterated radicals II and III, using the continuous wave saturation method. (author)

Selective enzymatic degradation of self-assembled particles from amphiphilic block copolymers obtained by the combination of N-carboxyanhydride and nitroxide-mediated polymerization

NARCIS (Netherlands)

Habraken, G.J.M.; Peeters, M.; Thornton, P.D.; Koning, C.E.; Heise, A.

2011-01-01

Combining controlled radical polymerizations and a controlled polypeptide synthetic technique, such as N-carboxyanhydride (NCA) ring-opening polymerization, enables the generation of well-defined block copolymers to be easily accessible. Here we combine NCA polymerization with the nitroxide-mediated

Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR

Science.gov (United States)

Yau, Wai-Ming; Thurber, Kent R.; Tycko, Robert

2014-07-01

We describe the synthesis of new nitroxide-based biradical, triradical, and tetraradical compounds and the evaluation of their performance as paramagnetic dopants in dynamic nuclear polarization (DNP) experiments in solid state nuclear magnetic resonance (NMR) spectroscopy with magic-angle spinning (MAS). Under our experimental conditions, which include temperatures in the 25-30 K range, a 9.4 T magnetic field, MAS frequencies of 6.2-6.8 kHz, and microwave irradiation at 264.0 GHz from a 800 mW extended interaction oscillator source, the most effective compounds are triradicals that are related to the previously-described compound DOTOPA-TEMPO (see Thurber et al., 2010), but have improved solubility in glycerol/water solvent near neutral pH. Using these compounds at 30 mM total nitroxide concentration, we observe DNP enhancement factors of 92-128 for cross-polarized 13C NMR signals from 15N,13C-labeled melittin in partially protonated glycerol/water, and build-up times of 2.6-3.8 s for 1H spin polarizations. Net sensitivity enhancements with biradical and tetraradical dopants, taking into account absolute 13C NMR signal amplitudes and build-up times, are approximately 2-4 times lower than with the best triradicals.

Temperature-induced variation in the intrinsic hyperfine separation of a tightly bound nitroxide spin label

Energy Technology Data Exchange (ETDEWEB)

Johnson, M.E.

1979-01-01

Recently there has been increasing interest in studying the rotational motion of biological molecules by monitoring the electron paramagnetic resonance (EPR) spectra of spin labels which are tightly bound to the molecule of interest. Theoretical studies have shown that in the slow motion region the correlation time may be determined by comparing the apparent hyperfine separation (HFS) in the presence of rotational motion with the rigid limit HFS in the absence of rotational motion. The majority of work to date has assumed the tightly bound nitroxide label to act simply as a reporter group for molecular motion, exhibiting little or no intrinsic environmental or temperature sensitivity. However, we have demonstrated that the rigid limit EPR spectra exhibit a substantial intrinsic temperature dependence, with the rigid limit HFS of MAL-6-labelled carboxyhemoglobin (HbCO) decreasing by nearly 10G over the temperature range -196/sup 0/C to +45/sup 0/C. The steepest temperature dependence was also found to occur over the 0 to 40/sup 0/C temperature range where most biological measurements are made. This strong temperature dependence in the intrinsic HFS was shown to produce substantial errors in correlation time calculations if it was not explicitly recognized and appropriate corrections made. This detailed behavior of this intrinsic temperature dependence suggests that it is most probably produced by equilibrium hydrogen bonding between the nitroxide NO/sup ./ group and an unidentified proton donor within the spin label binding site. (RJC)

Well-defined polyethylene-based graft terpolymers by combining nitroxide-mediated radical polymerization, polyhomologation and azide/alkyne “click” chemistry†

KAUST Repository

Alkayal, Nazeeha

2016-03-30

Novel well–defined polyethylene–based graft terpolymers were synthesized via the “grafting onto” strategy by combining nitroxide-mediated radical polymerization (NMP), polyhomologation and copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry. Three steps were involved in this approach: (i) synthesis of alkyne-terminated polyethylene-b-poly(ε-caprolactone) (PE-b-PCL-alkyne) block copolymers (branches) by esterification of PE-b-PCL-OH with 4-pentynoic acid; the PE-b-PCL-OH was obtained by polyhomologation of dimethylsulfoxonium methylide to afford PE-OH, followed by ring opening polymerization of ε-caprolactone using the PE-OH as macroinitiator, (ii) synthesis of random copolymers of styrene (St) and 4-chloromethylstyrene (4-CMS) with various CMS contents, by nitroxide-mediated radical copolymerization (NMP), and conversion of chloride to azide groups by reaction with sodium azide (NaN3) (backbone) and (iii) “click” linking reaction to afford the PE-based graft terpolymers. All intermediates and final products were characterized by high-temperature size exclusion chromatography (HT-SEC), Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy (1H NMR) and differential scanning calorimetry (DSC).

AN ALTERNATIVE ROUTE TO PRODUCE STANDARDS FOR GEL PERMEATION CHROMATOGRAPHY USING NITROXIDE MEDIATED POLYMERIZATION

Directory of Open Access Journals (Sweden)

C. P. R. Malere

Full Text Available Abstract All over the world standards for Gel Permeation Chromatography (GPC are produced using ionic polymerization. Standards are commercialized in a broad range of molecular weight and their dispersity (Ð must be lower than 1.1. This work proposes the synthesis of polystyrene standards using Nitroxide Mediated Polymerization (NMP, an alternative technique to produce controlled polymers that is much more robust when compared to ionic polymerization. Standards with different ranges of molecular weights were obtained, all of them with very narrow molecular weight distribution (MWD and dispersity (Ð lower than 1.10. In order to do that, several combinations of different initiators were tested. Advanced GPC Triple Detector was used to obtain important properties, such as absolute number and weight average molecular weights, dispersity and intrinsic viscosity. The analytical method used in the characterization of the samples was in-house validated in terms of linearity, accuracy, precision, repeatability and robustness. The validation study demonstrated the quality of the measurements and ensured that the information obtained for a given analyte by the GPC technique is reliable.

Nitroxide-mediated radical ring-opening copolymerization: chain-end investigation and block copolymer synthesis.

Science.gov (United States)

Delplace, Vianney; Harrisson, Simon; Tardy, Antoine; Gigmes, Didier; Guillaneuf, Yohann; Nicolas, Julien

2014-02-01

Well-defined, degradable copolymers are successfully prepared by nitroxide-mediated radical ring opening polymerization (NMrROP) of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) or methyl methacrylate (MMA), a small amount of acrylonitrile (AN) and cyclic ketene acetals (CKAs) of different structures. Phosphorous nuclear magnetic resonance allows in-depth chain-end characterization and gives crucial insights into the nature of the copoly-mer terminal sequences and the living chain fractions. By using a small library of P(OEGMA-co-AN-co-CKA) and P(MMA-co-AN-co-CKA) as macroinitiators, chain extensions with styrene are performed to furnish (amphiphilic) block copolymers comprising a degradable segment. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Redox properties of the nitronyl nitroxide antioxidants studied via their reactions with nitroxyl and ferrocyanide.

Science.gov (United States)

Bobko, A A; Khramtsov, V V

2015-01-01

Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents. Understanding redox chemistry of the NNs is important for their use as antioxidants and as paramagnetic probes for discriminative detection of NO and HNO by electron paramagnetic resonance (EPR) spectroscopy. Here we investigated the redox properties of the two most commonly used NNs, including determination of the equilibrium and rate constants of their reduction by HNO and ferrocyanide, and reduction potential of the couple NN/hydroxylamine of nitronyl nitroxide (hNN). The rate constants of the reaction of the NNs with HNO were found to be equal to (1-2) × 10(4) M(-1)s(- 1) being close to the rate constants of scavenging superoxide and NO by NNs. The reduction potential of the NNs and iminonitroxides (INs, product of NNs reaction with NO) were calculated based on their reaction constants with ferrocyanide. The obtained values of the reduction potential for NN/hNN (E'0 ≈ 285 mV) and IN/hIN (E' ≈ 495 mV) are close to the corresponding values for vitamin C and vitamin E, correspondingly. The "balanced" scavenging rates of the NNs towards superoxide, NO, and HNO, and their low reduction potential being thermodynamically close to the bottom of the pecking order of oxidizing radicals, might be important factors contributing into their antioxidant activity.

Ferromagnetic interactions in Ru(III)-nitronyl nitroxide radical complex: a potential 2p4d building block for molecular magnets.

Science.gov (United States)

Pointillart, Fabrice; Bernot, Kevin; Sorace, Lorenzo; Sessoli, Roberta; Gatteschi, Dante

2007-07-07

The reaction between [Ru(salen)(PPh3)Cl] and the 4-pyridyl-substituted nitronyl nitroxide radical (NITpPy) leads to the [Ru(salen)(PPh3)(NITpPy)](ClO4)(H2O)2 complex while the reaction with the azido anion (N3-) leads to the [Ru(salen)(PPh3)(N3)] complex 2 (where salen2- = N,N'-ethan-1,2-diylbis(salicylidenamine) and PPh3 = triphenylphosphine). Both compounds have been characterized by single crystal X-ray diffraction. The two crystal structures are composed by a [Ru(III)(salen)(PPh3)]+ unit where the Ru(III) ion is coordinated to a salen2- ligand and one PPh3 ligand in axial position. In 1 the Ru(III) ion is coordinated to the 4-pyridyl-substituted nitronyl nitroxide radical whereas in 2 the second axial position is occupied by the azido ligand. In both complexes the Ru(III) ions are in the same environment RuO2N3P, in a tetragonally elongated octhaedral geometry. The crystal packing of 1 reveals pi-stacking in pairs. While antiferromagnetic intermolecular interaction (J2 = 5.0 cm(-1)) dominates at low temperatures, ferromagnetic intramolecular interaction (J1 = -9.0 cm(-1)) have been found between the Ru(III) ion and the coordinated NITpPy.

The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice

DEFF Research Database (Denmark)

Kim, Christine H. J.; Mitchell, James B.; Bursill, Christina A.

2015-01-01

and a decrease in adiponectin. TEMPOL supplementation reversed these effects. When compared to HFD-fed mice, TEMPOL supplementation increased plaque collagen content, decreased lipid content and increased macrophage numbers. CONCLUSIONS: These data indicate that in a well-established model of obesity-associated......OBJECTIVE: The nitroxide compound TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl radical) has been shown to prevent obesity-induced changes in adipokines in cell and animal systems. In this study we investigated whether supplementation with TEMPOL inhibits inflammation and atherosclerosis...... in apoE(-/-) mice fed a high fat diet (HFD). METHODS: ApoE(-/-) mice were fed for 12 weeks on standard chow diet or a high-fat diet. Half the mice were supplemented with 10 mg/g TEMPOL in their food. Plasma samples were analysed for triglycerides, cholesterol, low- and high-density lipoprotein...

Mononitroxides and proximate dinitroxides derived by oxidation of 2,2,4,4,5,5-hexasubstituted imidazolidines. A new series of nitroxide and dinitroxide spin labels

International Nuclear Information System (INIS)

Keana, J.F.W.; Norton, R.S.; Morello, M.; Van Engen, D.; Clardy, J.

1978-01-01

The synthesis and some properties of two members of a new series of rigid dinitroxides in which the nitroxide groups are separated from each other by only one carbon atom are reported. The synthesis of reverse intermediate imidazolidine mononitroxides which may have potential as new spin labels is also reported

Stereocontrol of Methyl Methacrylate during Photoinduced Nitroxide-Mediated Polymerization in the Presence of Photosensitive Alkoxyamine

Directory of Open Access Journals (Sweden)

Juahui Su

2016-01-01

Full Text Available Photosensitive alkoxyamine 2,2,6,6-tetramethyl-1-(1-phenylethoxypiperidin-4-yl quinoline-2-carboxylate (PE-TEMPO-Q was synthesized. Photochemical properties of PE-TEMPO-Q were studied to develop photoinduced nitroxide-mediated polymerization of methyl methacrylate (MMA. Rapid and facile polymerization at ambient temperature with PE-TEMPO-Q as an initiator was confirmed to proceed in a controlled mechanism based on the linear growth in molecular weight combined with relative narrow polydispersity index (1.4–1.8 of the resulting polymers. The stereochemistry of obtained polymers was also investigated, and the syndiotacticity slightly increased compared with the typical photopolymerization. Dual-controlled photopolymerization of MMA was achieved in the presence of synthesized alkoxyamine.

Nuclear spin-lattice relaxation in nitroxide spin-label EPR.

Science.gov (United States)

Marsh, Derek

2016-11-01

Nuclear relaxation is a sensitive monitor of rotational dynamics in spin-label EPR. It also contributes competing saturation transfer pathways in T 1 -exchange spectroscopy, and the determination of paramagnetic relaxation enhancement in site-directed spin labelling. A survey shows that the definition of nitrogen nuclear relaxation rate W n commonly used in the CW-EPR literature for 14 N-nitroxyl spin labels is inconsistent with that currently adopted in time-resolved EPR measurements of saturation recovery. Redefinition of the normalised 14 N spin-lattice relaxation rate, b=W n /(2W e ), preserves the expressions used for CW-EPR, whilst rendering them consistent with expressions for saturation recovery rates in pulsed EPR. Furthermore, values routinely quoted for nuclear relaxation times that are deduced from EPR spectral diffusion rates in 14 N-nitroxyl spin labels do not accord with conventional analysis of spin-lattice relaxation in this three-level system. Expressions for CW-saturation EPR with the revised definitions are summarised. Data on nitrogen nuclear spin-lattice relaxation times are compiled according to the three-level scheme for 14 N-relaxation: T 1 n =1/W n . Results are compared and contrasted with those for the two-level 15 N-nitroxide system. Copyright © 2016 Elsevier Inc. All rights reserved.

Microstructural study of a nitroxide-mediated poly(ethylene oxide)/polystyrene block copolymer (PEO-b-PS) by electrospray tandem mass spectrometry.

Science.gov (United States)

Girod, Marion; Phan, Trang N T; Charles, Laurence

2008-08-01

Electrospray ionization tandem mass spectrometry has been used to characterize the microstructure of a nitroxide-mediated poly(ethylene oxide)/polystyrene block copolymer, called SG1-capped PEO-b-PS. The main dissociation route of co-oligomers adducted with lithium or silver cation was observed to proceed via the homolytic cleavage of a C-ON bond, aimed at undergoing reversible homolysis during nitroxide mediated polymerization. This cleavage results in the elimination of the terminal SG1 end-group as a radical, inducing a complete depolymerization process of the PS block from the so-formed radical cation. These successive eliminations of styrene molecules allowed a straightforward determination of the PS block size. An alternative fragmentation pathway of the radical cation was shown to provide structural information on the junction group between the two blocks. Proposed dissociation mechanisms were supported by accurate mass measurements. Structural information on the SG1 end-group could be reached from weak abundance fragment ions detected in the low m/z range of the MS/MS spectrum. Amongst fragments typically expected from PS dissociation, only beta ions were produced. Moreover, specific dissociation of the PEO block was not observed to occur in MS/MS, suggesting that these rearrangement reactions do not compete effectively with dissociations of the odd-electron fragment ions. Information about the PEO block length and the initiated end-group were obtained in MS(3) experiments.

Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress

Directory of Open Access Journals (Sweden)

Eva Griesser

2017-04-01

Full Text Available Reactive oxygen and nitrogen species (ROS/RNS play an important role in the regulation of cardiac function. Increase in ROS/RNS concentration results in lipid and protein oxidation and is often associated with onset and/or progression of many cardiovascular disorders. However, interplay between lipid and protein modifications has not been simultaneously studied in detail so far. Biomolecule carbonylation is one of the most common biomarkers of oxidative stress. Using a dynamic model of nitroxidative stress we demonstrated rapid changes in biomolecule carbonylation in rat cardiomyocytes. Levels of carbonylated species increased as early as 15 min upon treatment with the peroxynitrite donor, 3-morpholinosydnonimine (SIN-1, and decreased to values close to control after 16 h. Total (lipids+proteins vs. protein-specific carbonylation showed different dynamics, with a significant increase in protein-bound carbonyls at later time points. Treatment with SIN-1 in combination with inhibitors of proteasomal and autophagy/lysosomal degradation pathways allowed confirmation of a significant role of the proteasome in the degradation of carbonylated proteins, whereas lipid carbonylation increased in the presence of autophagy/lysosomal inhibitors. Electrophilic aldehydes and ketones formed by lipid peroxidation were identified and relatively quantified using LC-MS/MS. Molecular identity of reactive species was used for data-driven analysis of their protein targets. Combination of different enrichment strategies with LC-MS/MS analysis allowed identification of more than 167 unique proteins with 332 sites modified by electrophilic lipid peroxidation products. Gene ontology analysis of modified proteins demonstrated enrichment of several functional categories including proteins involved in cytoskeleton, extracellular matrix, ion channels and their regulation. Using calcium mobilization assays, the effect of nitroxidative stress on the activity of several ion

NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective.

Science.gov (United States)

Butler, A R; Flitney, F W; Williams, D L

1995-01-01

The multiplicity of biological functions thus far attributed to NO has led to suggestions that some effects might be mediated by other, related species instead. The radical nature of NO cannot account for its cytotoxicity, but its reaction with superoxide to form peroxynitite and highly reactive hydroxyl radicals may be important in this context. The ease with which NO can react with and destroy Fe-S clusters is also an important factor. Nitrosonium and nitroxide ions can be produced in vivo and will react under conditions that are physiologically relevant. Both could, in theory, serve in cell signalling or as cytotoxic agents. More direct experimental evidence for their involvement is needed before we can confidently assign them specific biological roles. In this article, Anthony Butler, Frederick Flitney and Lyn Williams discuss the chemistry of NO and related species.

Quenching of photoluminescence of colloidal ZnO nanocrystals by nitronyl nitroxide radicals

Energy Technology Data Exchange (ETDEWEB)

Stroyuk, Oleksandr L., E-mail: stroyuk@inphyschem-nas.kiev.ua [L.V. Pysarzhevsky Institute of Physical Chemistry of National Academy of Sciences of Ukraine, 31 Nauky avenue, 03028 Kyiv (Ukraine); Yakovenko, Anastasiya V.; Raevskaya, Oleksandra E. [L.V. Pysarzhevsky Institute of Physical Chemistry of National Academy of Sciences of Ukraine, 31 Nauky avenue, 03028 Kyiv (Ukraine); Plyusnin, Victor F. [Institute of Chemical Kinetics and Combustion of Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation)

2014-11-15

Quenching of the photoluminescence of colloidal zinc oxide nanocrystals by a series of stable nitronyl nitroxide radicals was studied by means of stationary and time-resolved luminescence spectroscopy. Among the studied radicals the most efficient quenchers of the ZnO luminescence are the carboxyl-substituted species. The meta-substituted radical was found to be a more active quencher, than para-substituted one due to a closer proximity of the radical center to the nanocrystals surface. The PL quenching has a complex dynamic/static character. The dynamic quenching arises from photocatalytic radical reduction by ZnO conduction band electrons, while the static quenching is caused by adsorption of the photoreduction products on the nanocrystal surface. The non-substituted and OH-substituted radicals are inferior to the products of their photoreduction in capability of adsorption of the ZnO surface, and the quenching is dominated by interactions between the nanocrystals and photoreduced hydroxylamines. In case of COOH-substituted radicals, however, the radicals compete with the photoreduction products for the surface sites of ZnO nanocrystals resulting in a dynamic character of photoluminescence quenching.

Dynamic changes in the distribution and time course of blood-brain barrier-permeative nitroxides in the mouse head with EPR imaging: visualization of blood flow in a mouse model of ischemia.

Science.gov (United States)

Emoto, Miho C; Sato-Akaba, Hideo; Hirata, Hiroshi; Fujii, Hirotada G

2014-09-01

Electron paramagnetic resonance (EPR) imaging using nitroxides as redox-sensitive probes is a powerful, noninvasive method that can be used under various physiological conditions to visualize changes in redox status that result from oxidative damage. Two blood-brain barrier-permeative nitroxides, 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (HMP) and 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy (MCP), have been widely used as redox-sensitive probes in the brains of small animals, but their in vivo distribution and properties have not yet been analyzed in detail. In this study, a custom-made continuous-wave three-dimensional (3D) EPR imager was used to obtain 3D EPR images of mouse heads using MCP or HMP. This EPR imager made it possible to take 3D EPR images reconstructed from data from 181 projections acquired every 60s. Using this improved EPR imager and magnetic resonance imaging, the distribution and reduction time courses of HMP and MCP were examined in mouse heads. EPR images of living mice revealed that HMP and MCP have different distributions and different time courses for entering the brain. Based on the pharmacokinetics of the reduction reactions of HMP and MCP in the mouse head, the half-lives of HMP and MCP were clearly and accurately mapped pixel by pixel. An ischemic mouse model was prepared, and the half-life of MCP was mapped in the mouse head. Compared to the half-life in control mice, the half-life of MCP in the ischemic model mouse brain was significantly increased, suggesting a shift in the redox balance. This in vivo EPR imaging method using BBB-permeative MCP is a useful noninvasive method for assessing changes in the redox status in mouse brains under oxidative stress. Copyright © 2014 Elsevier Inc. All rights reserved.

Smooth transition between SMM and SCM-type slow relaxing dynamics for a 1-D assemblage of {Dy(nitronyl nitroxide)2} units.

Science.gov (United States)

Liu, Ruina; Li, Licun; Wang, Xiaoling; Yang, Peipei; Wang, Chao; Liao, Daizheng; Sutter, Jean-Pascal

2010-04-21

A model example for size effects on the dynamic susceptibility behavior is provided by the chain compound [{Dy(hfac)(3)NitPhIm(2)}Dy(hfac)(3)] (NitPhIm = 2-[4-(1-imidazole)phenyl]nitronyl nitroxide radical). The Arrhenius plot reveals two relaxation regimes attributed to SMM (Delta = 17.1 K and tau(0) = 17.5 x 10(-6) s) and SCM (Delta = 82.7 K and tau(0) = 8.8 x 10(-8) s) behaviors. The ferromagnetic exchange among the spin carriers has been established for the corresponding Gd derivative.

Grafting of poly[(methyl methacrylate)-block-styrene] onto cellulose via nitroxide-mediated polymerization, and its polymer/clay nanocomposite.

Science.gov (United States)

Karaj-Abad, Saber Ghasemi; Abbasian, Mojtaba; Jaymand, Mehdi

2016-11-05

For the first time, nitroxide-mediated polymerization (NMP) was used for synthesis of graft and block copolymers using cellulose (Cell) as a backbone, and polystyrene (PSt) and poly(methyl metacrylate) (PMMA) as the branches. For this purpose, Cell was acetylated by 2-bromoisobutyryl bromide (BrBiB), and then the bromine group was converted to 4-oxy-2,2,6,6-tetramethylpiperidin-1-oxyl group by a substitution nucleophilic reaction to afford a macroinitiator (Cell-TEMPOL). The macroinitiator obtained was subsequently used in controlled graft and block copolymerizations of St and MMA monomers to yield Cell-g-PSt and Cell-g-(PMMA-b-PSt). The chemical structures of all samples as representatives were characterized by FTIR and (1)H NMR spectroscopies. In addition, Cell-g-(PMMA-b-PSt)/organophilic montmorillonite nanocomposite was prepared through a solution intercalation method. TEM was used to evaluate the morphological behavior of the polymer-clay system. It was demonstrated that the addition of small percent of organophilic montmorillonite (O-MMT; 3wt.%) was enough to improve the thermal stability of the nanocomposite. Copyright © 2016 Elsevier Ltd. All rights reserved.

Experimental study of living free radical polymerization using trifunctional initiator and polymerization mediated by nitroxide

International Nuclear Information System (INIS)

Galhardo, Eduardo; Lona, Liliane M.F.

2009-01-01

Controlled free radical polymerization or living free radical polymerization has received increasing attention as a technique for the production of polymers with microstructure highly controlled. In particular, narrow molecular weight distributions are obtained with polydispersity very close to one. In this research it was investigate the controlled polymerization mediated by nitroxide, using a cyclic trifunctional peroxide. As long as we know, there are only publications in literature dealing with NMRP using mono- and bi-functional initiators. It was believed that the trifunctional peroxide can increase the rate of polymerization, since more free radicals are generated, if compared with initiators with lower functionality. Furthermore, the fact of the initiator be cyclic means that branches are not generated in the chains, which theoretically prevents an increase in polydispersity of the polymer. The effect of the dissociation constant of the trifunctional initiator in the velocity of the reaction was analyzed. (author)

A study of the conformation and stability of nitroxide free radicals; Etude de la conformation et de la stabilite de radicaux libres nitroxydes

Energy Technology Data Exchange (ETDEWEB)

Briere, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-03-01

The first part of this study is an application of nuclear magnetic resonance to the determination of the sign and magnitude of the long range nuclear-electron spin-spin couplings in the free radical nitroxide derived from piperidine. It has been shown that the coupling constants of the protons {gamma} to the nitrogen atom have a pronounced spatial dependence as do the protons in the {beta} position, a point which has not been brought out by previous investigations. Conformational analysis of these compounds has been carried out by measurement of the effect of temperature on the NMR spectra at 310 MHz. The synthesis of di-t-Bu nitroxide labelled with C{sup 13} in the {alpha}-position made possible the unambiguous determination of the corresponding {sup 13}C nuclear-electron spin-spin coupling constant, a parameter which had not previously been measured. The coupling constants measured in the 2,2,6,6-tetramethyl piperidine series could then be attributed to the {sup 13}C atoms in the {beta}-position and their variation related to the conformations of the heterocycles. This constitutes the second part of the work reported here. The final section is devoted to a study of the decomposition of an unstable nitroxide having a hydrogen atom in the p-position. This decomposition is bimolecular and the primary isotope effect shows that the rupture. of the C-H bond is involved. From this one can conclude that a nitroxide is stable when the different groups attached to the nitrogen atom cannot give rise to a decomposition either intra molecularly, if the molecular geometry is suitable, or inter molecularly by dimerisation through attack on a different center of a neighbouring molecule thus leading to a fragmentation or a disproportionation. (author) [French] La premiere partie est une application de la resonance magnetique nucleaire a la determination du signe et de la grandeur des couplages a longue distance dans des radicaux libres nitroxydes piperidiniques. Il est montre que

Supplier Selection Using Weighted Utility Additive Method

Science.gov (United States)

Karande, Prasad; Chakraborty, Shankar

2015-10-01

Supplier selection is a multi-criteria decision-making (MCDM) problem which mainly involves evaluating a number of available suppliers according to a set of common criteria for choosing the best one to meet the organizational needs. For any manufacturing or service organization, selecting the right upstream suppliers is a key success factor that will significantly reduce purchasing cost, increase downstream customer satisfaction and improve competitive ability. The past researchers have attempted to solve the supplier selection problem employing different MCDM techniques which involve active participation of the decision makers in the decision-making process. This paper deals with the application of weighted utility additive (WUTA) method for solving supplier selection problems. The WUTA method, an extension of utility additive approach, is based on ordinal regression and consists of building a piece-wise linear additive decision model from a preference structure using linear programming (LP). It adopts preference disaggregation principle and addresses the decision-making activities through operational models which need implicit preferences in the form of a preorder of reference alternatives or a subset of these alternatives present in the process. The preferential preorder provided by the decision maker is used as a restriction of a LP problem, which has its own objective function, minimization of the sum of the errors associated with the ranking of each alternative. Based on a given reference ranking of alternatives, one or more additive utility functions are derived. Using these utility functions, the weighted utilities for individual criterion values are combined into an overall weighted utility for a given alternative. It is observed that WUTA method, having a sound mathematical background, can provide accurate ranking to the candidate suppliers and choose the best one to fulfill the organizational requirements. Two real time examples are illustrated to prove

Qualitative Methods in Drug Utilization Research

DEFF Research Database (Denmark)

Almarsdóttir, Anna Birna; Bastholm Rahmner, Pia

2016-01-01

Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider...... understanding of why and how it appears. Qualitative research methods build on various theoretical underpinnings/schools of thought. The same validity and quality criteria cannot be used for both qualitative and quantitative methods....

Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques

Science.gov (United States)

Potapenko, Dmitrii I.; Foster, Margaret A.; Lurie, David J.; Kirilyuk, Igor A.; Hutchison, James M. S.; Grigor'ev, Igor A.; Bagryanskaya, Elena G.; Khramtsov, Valery V.

2006-09-01

New improved pH-sensitive nitroxides were applied for in vivo studies. An increased stability of the probes towards reduction was achieved by the introduction of the bulky ethyl groups in the vicinity of the paramagnetic N sbnd O fragment. In addition, the range of pH sensitivity of the approach was extended by the synthesis of probes with two ionizable groups, and, therefore, with two p Ka values. Stability towards reduction and spectral characteristics of the three new probes were determined in vitro using 290 MHz radiofrequency (RF)- and X-band electron paramagnetic resonance (EPR), longitudinally detected EPR (LODEPR), and field-cycled dynamic nuclear polarization (FC-DNP) techniques. The newly synthesized probe, 4-[bis(2-hydroxyethyl)amino]-2-pyridine-4-yl-2,5,5-triethyl-2,5-dihydro-1 H-imidazol-oxyl, was found to be the most appropriate for the application in the stomach due to both higher stability and convenient pH sensitivity range from pH 1.8 to 6. LODEPR, FC-DNP and proton-electron double resonance imaging (PEDRI) techniques were used to detect the nitroxide localization and acidity in the rat stomach. Improved probe characteristics allowed us to follow in vivo the drug-induced perturbation in the stomach acidity and its normalization afterwards during 1 h or longer period of time. The results show the applicability of the techniques for monitoring drug pharmacology and disease in the living animals.

Homoleptic Ce(III) and Ce(IV) Nitroxide Complexes: Significant Stabilization of the 4+ Oxidation State

Energy Technology Data Exchange (ETDEWEB)

Bogart, Justin A.; Lewis, Andrew J.; Medling, Scott A.; Piro, Nicholas A.; Carroll, Patrick J.; Booth, Corwin H.; Schelter, Eric J.

2014-06-25

Electrochemical experiments performed on the complex Ce-IV[2-((BuNO)-Bu-t)py](4), where [2-((BuNO)-Bu-t)py](-) = N-tert-butyl-N-2-pyridylnitroxide, indicate a 2.51 V stabilization of the 4+ oxidation state of Ce compared to [(Bu4N)-Bu-n](2)[Ce(NO3)(6)] in acetonitrile and a 2.95 V stabilization compared to the standard potential for the ion under aqueous conditions. Density functional theory calculations suggest that this preference for the higher oxidation state is a result of the tetrakis(nitroxide) ligand framework at the Ce cation, which allows for effective electron donation into, and partial covalent overlap with, vacant 4f orbitals with delta symmetry. The results speak to the behavior of CeO2 and related solid solutions in oxygen uptake and transport applications, in particular an inherent local character of bonding that stabilizes the 4+ oxidation state. The results indicate a cerium(IV) complex that has been stabilized to an unprecedented degree through tuning of its ligand-field environment.

IRP methods for Environmental Impact Statements of utility expansion plans

International Nuclear Information System (INIS)

Cavallo, J.D.; Hemphill, R.C.; Veselka, T.D.

1992-01-01

Most large electric utilities and a growing number of gas utilities in the United States are using a planning method -- Integrated Resource Planning (IRP) - which incorporates demand-side management (DSM) programs whenever the marginal cost of the DSM programs are lower than the marginal cost of supply-side expansion options. Argonne National Laboratory has applied the IRP method in its socio-economic analysis of an Environmental Impact Statement (EIS) of power marketing for a system of electric utilities in the mountain and western regions of the United States. Applying the IRP methods provides valuable information to the participants in an EIS process involving capacity expansion of an electric or gas utility. The major challenges of applying the IRP method within an EIS are the time consuming and costly task of developing a least cost expansion path for each altemative, the detailed quantification of environmental damages associated with capacity expansion, and the explicit inclusion of societal-impacts to the region

Preparation and physico-chemical study of nitroxide radicals. Isotopic marking with carbon 13 and deuterium; Preparations et etudes physico-chimiques de radicaux nitroxydes. Marquage isotopique au carbone 13 et au deuterium

Energy Technology Data Exchange (ETDEWEB)

Chapelet-Letourneux, G [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-07-01

N-t-butyl-N-phenyl nitroxide is obtained by: a) action of t-butyl-magnesium chloride on nitrobenzene, or of phenyl-magnesium bromide on nitro-t-butane, b) oxidation of N-t-butyl-N-phenylhydroxylamine, c) oxidation of N-t-butylaniline. In these latter two cases, it has been possible to isolate the pure radical and to study it using UV, IR and EPR. It decomposes to give N-t-butylaniline and the N-oxide of N-t-butyl-p-quinon-imine. The action of peracids such as p-nitro-perbenzoic or m-chloro-perbenzoic acids on amines or hydroxylamines leads to the formation of stable or unstable nitroxide radicals easily observable by EPR. Finally, with a view to obtaining definite values for the coupling between the free electron of a nitroxide and carbon 13, the preparation of such radicals marked with {sup 13}C in the {alpha} or {beta} position of the nitroxide function has been carried out. The coupling with an {alpha} carbon 13 is negative and does not appear to vary with the spin density on the nitrogen. The interaction with the p nuclei of the nitrogen depends on the nature of the substituents: the two benzyl protons have a hyperfine splitting a{sub H} which is always less than that of the ethyl. On the other hand, the {sup 13}C coupling is greater in the first case. The usually adopted conformations for the compounds having the carbonyl group cannot account for the observed values of the {beta} couplings. (author) [French] Le N-t-butyl-N-phenyl nitroxyde est obtenu par: a) action du chlorure de t-butylmagnesium sur le nitrobenzene, ou du bromure de phenylmagnesium sur le nitro-t-butane, b) oxydation de la N-t-butyl-N-phenylhydroxylamine, c) oxydation de la N-t-butylaniline. Dans ces deux derniers cas, le radical a pu etre isole pur et etudie par UV, IR et RPE. Il se decompose en N-t-butylaniline et N-oxyde de N-t-butyl-p-quinonimine. L'action de peracides (p-nitroperbenzoique ou m-chloroperbenzoique) sur des amines ou des hydroxylamines conduit a des radicaux nitroxydes

Utilities' nuclear fuel economic evaluation methods

International Nuclear Information System (INIS)

Sonz, L.A.

1987-01-01

This paper presents the typical perceptions, methods, considerations, and procedures used by an operating electric utility in the economic evaluation of nuclear fuel preparation and utilization scenarios. The means given are probably not an exclusive review of those available, but are the author's recollection of systems employed to select and recommend preferable courses of action. Economic evaluation of proposed nuclear fuel scenarios is an important, but not exclusive, means of deciding on corporate action. If the economic evaluation is performed and coordinated with the other corporate considerations, such as technical and operational ability, electrical system operations management, tax effects, capital management, rates impact, etc., then the resultant recommendation may be employed to the benefit of the customers and, consequently, to the corporation

Dynamic, in vivo, real-time detection of retinal oxidative status in a model of elevated intraocular pressure using a novel, reversibly responsive, profluorescent nitroxide probe.

Science.gov (United States)

Rayner, Cassie L; Gole, Glen A; Bottle, Steven E; Barnett, Nigel L

2014-12-01

Changes to the redox status of biological systems have been implicated in the pathogenesis of a wide variety of disorders including cancer, Ischemia-reperfusion (I/R) injury and neurodegeneration. In times of metabolic stress e.g. ischaemia/reperfusion, reactive oxygen species (ROS) production overwhelms the intrinsic antioxidant capacity of the cell, damaging vital cellular components. The ability to quantify ROS changes in vivo, is therefore essential to understanding their biological role. Here we evaluate the suitability of a novel reversible profluorescent probe containing a redox-sensitive nitroxide moiety (methyl ester tetraethylrhodamine nitroxide, ME-TRN), as an in vivo, real-time reporter of retinal oxidative status. The reversible nature of the probe's response offers the unique advantage of being able to monitor redox changes in both oxidizing and reducing directions in real time. After intravitreal administration of the ME-TRN probe, we induced ROS production in rat retina using an established model of complete, acute retinal ischaemia followed by reperfusion. After restoration of blood flow, retinas were imaged using a Micron III rodent fundus fluorescence imaging system, to quantify the redox-response of the probe. Fluorescent intensity declined during the first 60 min of reperfusion. The ROS-induced change in probe fluorescence was ameliorated with the retinal antioxidant, lutein. Fluorescence intensity in non-Ischemia eyes did not change significantly. This new probe and imaging technology provide a reversible and real-time response to oxidative changes and may allow the in vivo testing of antioxidant therapies of potential benefit to a range of diseases linked to oxidative stress. Copyright © 2014 Elsevier Ltd. All rights reserved.

Barriers to utilization of modern methods of family planning amongst ...

African Journals Online (AJOL)

Barriers to utilization of modern methods of family planning amongst women in a ... is recognized by the world health organization (WHO) as a universal human right. ... Conclusion: The study finds numerous barriers to utilization of family ...

Chemical modification of polyaniline by N-grafting of polystyrenic chains synthesized via nitroxide-mediated polymerization

International Nuclear Information System (INIS)

Hatamzadeh, Maryam; Mahyar, Ali; Jaymand, Mehdi

2012-01-01

This study aims to explore an effective route for the preparation of conductive N-substituted polyaniline (PANI) by the incorporation of brominated poly(styrene-co-p-methylstyrene) onto the emeraldine form of polyaniline. For this purpose, at first, poly(styrene-co-p-methylstyrene) was synthesized via nitroxide-mediated polymerization (NMP), and then, N-bromosuccinimide was used as brominating agent to obtain a copolymer with bromine. Thereafter, deprotonated polyaniline was reacted with brominated poly(styrene-co-p-methylstyrene) to prepare the poly(styrene-co-p-methylstyrene)-graft-polyaniline [(PSt-co-PMSt)-g-PANI] terpolymer through N-grafting reaction. The terpolymer was characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Optical properties of (PSt-co-PMSt)-g-PANI in the undoped and doped states were obtained by ultraviolet-visible spectroscopy (UV-Vis), and electrical conductivity at room temperature was measured using samples in which the conductive materials was sandwiched between two Ni electrodes. Moreover, electroactivity of the synthesized terpolymer was verified under cyclic voltammetric conditions on the surface of the working glassy carbon electrode (GCE). The solubility of (PSt-co-PMSt)-g-PANI terpolymer was examined in common organic solvents, such as, tetrahydrofuran (THF), chloroform and xylene. (author)

Methods of determining incremental energy costs for economic dispatch and inter-utility interchange in Canadian utilities

International Nuclear Information System (INIS)

El-Hawary, M.E.; El-Hawary, F.; Mbamalu, G.A.N.

1991-01-01

A questionnaire was mailed to ten Canadian utilities to determine the methods the utilities use in determining the incremental cost of delivering energy at any time. The questionnaire was divided into three parts: generation, transmission and general. The generation section dealt with heat rates, fuel, operation and maintenance, startup and shutdown, and method of prioritizing and economic evaluation of interchange transactions. Transmission dealt with inclusion of transmission system incremental maintenance costs, and transmission losses determination. The general section dealt with incremental costs aspects, and various other economic considerations. A summary is presented of responses to the questionnaire

Utilization pattern of extension tools and methods by Agricultural Extension Agents

Directory of Open Access Journals (Sweden)

M Surudhi

2018-05-01

Full Text Available A study was conducted in Krishnagiri district of Tamil Nadu state to understand the utilization pattern of extension tools and methods by the agricultural extension agents. As ICT revolution is slowly conquering the rural sector, it becomes imperative that the agricultural extension agents transform themselves to the changing times and develop competencies in utilizing these ICTs.  The study explored the usage of various extension tools and methods by the change agents and the constraints faced in utilizing them. The findings revealed that the extension functionaries frequently used the individual contact methods viz., telephone, office calls and farm and home visits in the process of transfer of technology. Least efforts were shown in sending SMS based communication. Meetings were the common and frequently adopted group contact method. Demonstrations, farmer field school, farmer’s interest groups, field trips and farmer training programmes were moderately adopted. Posters, leaflets and pre-season campaigns were the widely adopted mass contact methods. They possess least skill in utilizing farm magazines, presenting television and radio programmes, which are among the most popular and most efficient mass contact methods. The extension functionaries need to be trained adequately on the wider use of electronic communication methods like e mails, and SMS in the local language. Efforts should be taken up to sensitize the importance and train the extension agents in the usage of different group and mass contact methods.

Correlation between the rate of bioreduction of nitroxide spin label by human tumor cells and their low-dose radiation response

International Nuclear Information System (INIS)

Halpern, H.J.; Peric, M.; Nguyen, T.D.; Spencer, D.P.; Bowman, M.K.; Beckett, M.; Weichselbaum, R.R.

1988-01-01

The authors discuss a correlation observed between the bioreduction of nitroxide spin label by four human tumor cell lines and a normal tissue fibroblast clone and their low-dose radiation response, specifically their D Q . In measurements of the bioreduction rate of several other cell lines, this correlation appears to persist. In order to define the mechanism of this correlation, they have begun by subtly altering the measurement conditions. The original conditions for measurement involved adding the spin label to cells whose culture medium had been changed (the label was added to the new medium). By delaying the addition of the label to the culture medium, they substantially reduced the variation of the bioreduction rate between the cell lines. This implies that the fresh medium provides a nonspecific irritant or disequilibrium to the cultured cell system to which they response variably by accelerating, among other things, the metabolic process responsible for spin label bioreduction

Nitroxide free radical clearance in the live rat monitored by radio-frequency CW-EPR and PEDRI

International Nuclear Information System (INIS)

Alecci, Marcello; Seimenis, Ioannis; McCallum, Stephen J.; Lurie, David J.; Foster, Margaret A.

1998-01-01

The use of RF (100 to 300 MHz) PEDRI and CW-EPR techniques allows the in vivo study of large animals such as whole rats and rabbits. Recently a PEDRI instrument was modified to also allow CW-EPR spectroscopy with samples of similar size and under the same experimental conditions. In the present study, this CW-EPR and PEDRI apparatus was used to assess the feasibility of the detection of a pyrrolidine nitroxide free radical (2,2,5,5,-tetramethylpyrrolidine-1-oxyl-3-carboxylic acid, PCA) in the abdomen of rats. In particular, we have shown that after the PCA administration (4 mmol kg -1 b.w.): (i) the PCA EPR linewidth does not show line broadening due to concentration effects; (ii) a similar PCA up-take phase is observed by EPR and PEDRI; and (iii) the PCA half-lives in the whole abdomen of rats measured with the CW-EPR (T 1/2 =26±4 min, mean±sd, n=10) and PEDRI (T 1/2 =29±4 min, mean±sd, n=4) techniques were not significantly different (p>0.05). These results show, for the first time, that information about PCA pharmacokinetics obtained by CW-EPR is the same as that from PEDRI under the same experimental conditions. (author)

XMCD for monitoring exchange interactions. The role of the Gd 4f and 5d orbitals in metal-nitronyl nitroxide magnetic chains.

Science.gov (United States)

Champion, Guillaume; Lalioti, Nikolia; Tangoulis, Vassilis; Arrio, Marie-Anne; Sainctavit, Philippe; Villain, Françoise; Caneschi, Andrea; Gatteschi, Dante; Giorgetti, Christine; Baudelet, François; Verdaguer, Michel; Cartier dit Moulin, Christophe

2003-07-09

We report here the X-ray magnetic circular dichroism (XMCD) study at the Gd M(4,5)- and L(2,3)-edges of two linear magnetic chains involving Gd(III) cations bridged by nitronyl nitroxide radicals. This spectroscopy directly probes the magnetic moments of the 4f and 5d orbitals of the gadolinium ions. We compare macroscopic magnetic measurements and local XMCD signals. The M(4,5)-edges results are in agreement with the J values extracted from the fits of the SQUID magnetic measurements. The L(2,3)-edges signals show that the electronic density in the Gd 5d orbitals depends on the neighbors of the gadolinium cations. Nevertheless, the 5d orbitals do not seem to play any role in the superexchange pathway between radicals through the metal ion proposed to explain the particular magnetic exchange interactions between the radicals in these chains.

Solar energy utilization by physical methods.

Science.gov (United States)

Wolf, M

1974-04-19

On the basis of the estimated contributions of these differing methods of the utilization of solar energy, their total energy delivery impact on the projected U.S. energy economy (9) can be evaluated (Fig. 5). Despite this late energy impact, the actual sales of solar energy utilization equipment will be significant at an early date. Potential sales in photovoltaic arrays alone could exceed $400 million by 1980, in order to meet the projected capacity buildup (10). Ultimately, the total energy utilization equipment industry should attain an annual sales volume of several tens of billion dollars in the United States, comparable to that of several other energy related industries. Varying amounts of technology development are required to assure the technical and economic feasibility of the different solar energy utilization methods. Several of these developments are far enough along that the paths can be analyzed from the present time to the time of demonstration of technical and economic feasibility, and from there to production and marketing readiness. After that point, a period of market introduction will follow, which will differ in duration according to the type of market addressed. It may be noted that the present rush to find relief from the current energy problem, or to be an early leader in entering a new market, can entail shortcuts in sound engineering practice, particularly in the areas of design for durability and easy maintenance, or of proper application engineering. The result can be loss of customer acceptance, as has been experienced in the past with various products, including solar water heaters. Since this could cause considerable delay in achieving the expected total energy impact, it will be important to spend adequate time at this stage for thorough development. Two other aspects are worth mentioning. The first is concerned with the economic impacts. Upon reflection on this point, one will observe that largescale solar energy utilization will

Methods of fabricating cermet materials and methods of utilizing same

Science.gov (United States)

Kong, Peter C.

2006-04-04

Methods of fabricating cermet materials and methods of utilizing the same such as in filtering particulate and gaseous pollutants from internal combustion engines having intermetallic and ceramic phases. The cermet material may be made from a transition metal aluminide phase and an aluminia phase. The mixture may be pressed to form a green compact body and then heated in a nitrogen-containing atmosphere so as to melt aluminum particles and form the cermet. Filler materials may be added to increase the porosity or tailor the catalytic properties of the cermet material. Additionally, the cermet material may be reinforced with fibers or screens. The cermet material may also be formed so as to pass an electrical current therethrough to heat the material during use.

Methods of producing cermet materials and methods of utilizing same

Science.gov (United States)

Kong, Peter C [Idaho Falls, ID

2008-12-30

Methods of fabricating cermet materials and methods of utilizing the same such as in filtering particulate and gaseous pollutants from internal combustion engines having intermetallic and ceramic phases. The cermet material may be made from a transition metal aluminide phase and an alumina phase. The mixture may be pressed to form a green compact body and then heated in a nitrogen-containing atmosphere so as to melt aluminum particles and form the cermet. Filler materials may be added to increase the porosity or tailor the catalytic properties of the cermet material. Additionally, the cermet material may be reinforced with fibers or screens. The cermet material may also be formed so as to pass an electrical current therethrough to heat the material during use.

In vivo EPR imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl

Science.gov (United States)

Redler, Gage; Barth, Eugene D.; Bauer, Kenneth S.; Kao, Joseph P.Y.; Rosen, Gerald M.; Halpern, Howard J.

2015-01-01

Purpose EPR spectroscopy promises quantitative images of important physiologic markers of animal tumors and normal tissues, such as pO2, pH, and thiol redox status. These parameters of tissue function are conveniently reported by tailored nitroxides. For defining tumor physiology, it is vital that nitroxides are selectively localized in tumors relative to normal tissue. Furthermore, these paramagnetic species should be specifically taken up by cells of the tumor, thereby reporting on both the site of tumor formation and the physiological status of the tissue. This study investigates the tumor localization of the novel nitroxide, cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl 3 relative to the corresponding di-acid 4. Methods We obtained images of nitroxide 3 infused intravenously into C3H mice bearing 0.5-cm3 FSa fibrosarcoma on the leg, and compared these with images of similar tumors infused with nitroxide 4. Results The ratio of spectral intensity from within the tumor-bearing region to that of normal tissue was higher in the mice injected with 3 relative to 4. Conclusion This establishes the possibility of tumor imaging with a nitroxide with intracellular distribution and provides the basis for EPR images of animal models to investigate the relationship between crucial aspects of tumor microenvironment and malignancy and its response to therapy. PMID:23776127

E. P. R. spectroscopic study of nitroxide mono- and bi-radicals; Etude par spectroscopie de resonance paramagnetique electronique de monoradicaux et de biradicaux nitroxydes

Energy Technology Data Exchange (ETDEWEB)

Lemaire, H [Commissariat a l' Energie Atomique, Grenoble, 38 (France). Centre d' Etudes Nucleaires

1967-07-01

A nitroxide is a molecule containing the group N-O where the oxygen atom made only one bond instead of the usual two. The main advantage of these radicals is their exceptional stability; this allows the study of well defined chemical structures while varying at will the experimental conditions. Studies by electron paramagnetic resonance of nitroxide mono-radicals have given the principal directions and the principal values of the electron-nitrogen nucleus hyperfine tensor and of the anisotropic g-factor tensor. The results were then related to the electronic structure of radicals. An understanding was obtained of the influence of the solvent on the principal values of the tensors, and the marked differences observed in the broadening of hyperfine lines when the medium become viscous. In the nitroxide biradicals, the hyperfine spectra depends not only on the magnetic interactions relative to each monomer, but also on the magnitude of the exchange interaction between the singlet and the triplet states of the dimer; the biradicals studied here are the first organic compounds which show clearly the influence of this exchange on the hyperfine structure. The two unpaired electrons also interact by a magnetic dipolar interaction: in the intermediate case, this can be used to derive the sign of the exchange interaction if the bi-radical is studied in a liquid crystal. Just as for mono-radicals, the hyperfine spectra of bi-radicals show selective broadening in viscous media, which is caused by an overall motional modulation of the anisotropic tensors. This gives another way to determine the sign of the exchange interaction. (author) [French] On appelle nitroxyde une molecule contenant le groupement N-O ou l'atome d'oxygene n'a satisfait qu'une seule liaison de valence sur les deux qui lui sont habituelles. L'interet majeur de ces radicaux reside dans leur exceptionnelle stabilite, permettant ainsi de faire varier a loisir les conditions experimentales d'etude de produits

Decentralized method for utility regulation

Energy Technology Data Exchange (ETDEWEB)

Loeb, M. (North Carolina State Univ., Raleigh); Magat, W.A.

1979-10-01

A new institutional arrangement for regulating utilities is suggested that minimizes the costs of natural monopolies. A mixture of regulation and franchising, the plan draws on the advantages of each and eliminates many of the problems. The proposal allows utilities to set their own price on the basis of demand and marginal-cost projections. Subsidies are provided by the regulatory agency if there is a consumer surplus. The system encourages the utility to select a competitive price and to produce only the amount of service needed. Operating efficiency is encouraged by rewarding cost reductions and discouraging cost overstatement at the rate review. The regulatory agency would not need to take action to bring price and marginal costs into equality. The franchise sale can be made by competitive bidding, in which the bidders would capitalize part or all of the subsidy or the regulatory agency could recover the subsidy in a lump-sum tax on the utility.

In search of a new class of stable nitroxide: synthesis and reactivity of a peri-substituted N,N-bissulfonylhydroxylamine.

Science.gov (United States)

Patel, Bhaven; Carlisle, Julie; Bottle, Steven E; Hanson, Graeme R; Kariuki, Benson M; Male, Louise; McMurtrie, John C; Spencer, Neil; Grainger, Richard S

2011-04-07

Acyclic bissulfonylnitroxides have never been isolated, and degrade through fragmentation. In an approach to stabilising a bissulfonylnitroxide radical, the cyclic, peri-substituted N,N-bissulfonylhydroxylamine, 2-hydroxynaphtho[1,8-de][1,3,2]dithiazine 1,1,3,3-tetraoxide (1), has been prepared by formal nitrogen insertion into the sulfur-sulfur bond of a sulfinylsulfone, naphtho[1,8-cd][1,2]dithiole 1,1,2-trioxide. The heterocyclic ring of 1 is shown to adopt a sofa conformation by X-ray crystallography, with a pseudo-axial hydroxyl group. N,N-Bissulfonylhydroxylamine 1 displays high thermal, photochemical and hydrolytic stability compared to acyclic systems. EPR analysis reveals formation of the corresponding bissulfonylnitroxide 2 upon oxidation of 1 with the Ce(IV) salts CAN and CTAN. Although 2 does not undergo fragmentation, it cannot be isolated, since hydrogen atom abstraction to reform 1 occurs in situ. The stability and reactivity of 1 and 2 are compared with the known cyclic benzo-fused N,N-bissulfonylhydroxylamine, N-hydroxy-O-benzenedisulfonimide (6), for which the X-ray data, and EPR of the corresponding nitroxide 10, are also reported for the first time.

Method for aluminium dross utilization

International Nuclear Information System (INIS)

Lucheva, B.; Petkov, R.; Tzonev, Tz.

2003-01-01

A new hydrometallurgical method has been developed for metal aluminum utilization from secondary aluminum dross. Secondary aluminum dross is a powder product with an average of 35% aluminium content (below 1mm). It is waste from primary aluminum dross pyrometallurgical flux less treatment in rotary DC electric arc furnace. This method is based on aluminum leaching in copper chloride water solution. As a result an aluminum oxychloride solution and solids, consisting of copper and oxides are obtained. In order to copper chloride solution regenerate hydrochloric acid is added to the solids. The process is simple, quick, economic and safe. The aluminum oxychloride solution contains 56 g/l Al 2 O 3 . The molar ratios are Al:Cl=0,5; OH:Al=1. The solution has 32 % basicity and 1,1 g/cm 3 density. For increasing the molar ratio of aluminium to chlorine aluminum hydroxide is added to this solution at 80 o C. Aluminum hydroxide is the final product from the secondary aluminum dross alkaline leaching. As a result aluminum oxychloride solution of the following composition is prepared: Al 2 O 3 - 180 g/l; Al:Cl=1,88; OH:Al=4,64; basicity 82%; density 1,22 g/cm 3 , pH=4 -4,5. Aluminum oxychloride solution produced by means of this method can be used in potable and wastewater treatment, paper making, in refractory mixture as a binder etc. (Original)

Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress.

Science.gov (United States)

Salat, Kinga; Moniczewski, Andrzej; Librowski, Tadeusz

2013-03-01

Numerous lines of evidence suggest that heterocyclic compounds used as analgesic, anti-inflammatory and anti-migraine agents can be potent regulators of the nitroxidative stress and targeting free nitrogen and oxygen radicals is a very promising strategy for future pain management. Both classical analgesics (nonsteroidal anti-inflammatory drugs, opioid drugs) and many analgesic adjuvants, including desipramine, duloxetine, fluoxetine, paroxetine, escitalopram, phenytoin or carbamazepine and α-lipoic acid can modulate the balance between pro-oxidant and antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic drugs formed by the activity of tissue peroxidases may contribute to their clinical efficacy and drug-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance. The antioxidant capacities of novel heterocyclic compounds, including the compounds acting either by prevention of formation or catalyzed decomposition of peroxynitrite anion (ONOO-), namely the peroxynitrite decomposition catalysts or as superoxide (O2 •-)-scavengers which are the functional mimetics of superoxide dismutase (SOD) enzymes (SODm), as well as the derivatives of 6-nitro-3,4-methylenedioxyphenyl-Nacylhydrazone (LASSBio-881) or γ-butyrolactone (LPP1, BM113, BM113A, BM138 and BM138A) are also discussed as potent and promising future heterocyclic analgesics.

Utilization of OR method toward realization of better fast breeder reactor cycle

International Nuclear Information System (INIS)

Shiotani, Hiroki

2008-01-01

Fast Reactor Cycle Technology Development (FaCT) Project was now started aiming at commercialization of new nuclear power plants system. In parallel with development of component technology and technology demonstration by test, development of comprehensive evaluation method of the FBR cycle system is under way and scenario study, discounted cash flow (DCF) method, analytic hierarchy process (AHP), real option, supply chain management (SCM) and others are used. Since commercialized FBR cycle would request long-term and large-scale development contributed by so many participants, modeling of nuclear system and knowledge management are beneficial even for development of evaluation method and further utilization of OR technology is highly expected. Comprehensive evaluation methods now utilized or developing were overlooked from the standpoint of OR, 'Science of Better'. (T. Tanaka)

Comparison of direct and indirect methods of estimating health state utilities for resource allocation: review and empirical analysis.

Science.gov (United States)

Arnold, David; Girling, Alan; Stevens, Andrew; Lilford, Richard

2009-07-22

Utilities (values representing preferences) for healthcare priority setting are typically obtained indirectly by asking patients to fill in a quality of life questionnaire and then converting the results to a utility using population values. We compared such utilities with those obtained directly from patients or the public. Review of studies providing both a direct and indirect utility estimate. Papers reporting comparisons of utilities obtained directly (standard gamble or time tradeoff) or indirectly (European quality of life 5D [EQ-5D], short form 6D [SF-6D], or health utilities index [HUI]) from the same patient. PubMed and Tufts database of utilities. Sign test for paired comparisons between direct and indirect utilities; least squares regression to describe average relations between the different methods. Mean utility scores (or median if means unavailable) for each method, and differences in mean (median) scores between direct and indirect methods. We found 32 studies yielding 83 instances where direct and indirect methods could be compared for health states experienced by adults. The direct methods used were standard gamble in 57 cases and time trade off in 60(34 used both); the indirect methods were EQ-5D (67 cases), SF-6D (13), HUI-2 (5), and HUI-3 (37). Mean utility values were 0.81 (standard gamble) and 0.77 (time tradeoff) for the direct methods; for the indirect methods: 0.59(EQ-5D), 0.63 (SF-6D), 0.75 (HUI-2) and 0.68 (HUI-3). Direct methods of estimating utilities tend to result in higher health ratings than the more widely used indirect methods, and the difference can be substantial.Use of indirect methods could have important implications for decisions about resource allocation: for example, non-lifesaving treatments are relatively more favoured in comparison with lifesaving interventions than when using direct methods.

Drug utilization according to reason for prescribing: a pharmacoepidemiologic method based on an indication hierarchy

DEFF Research Database (Denmark)

Kildemoes, Helle Wallach; Hendriksen, Carsten; Morten, Andersen

2011-01-01

ABSTRACT Purpose To develop a pharmacoepidemiologic method for drug utilization analysis according to indication, gender, and age by means of register-based information. Statin utilization in 2005 was applied as an example. Methods Following the recommendations for statin therapy, we constructed ...

Utility of three-dimensional method for diagnosing meniscal lesions

International Nuclear Information System (INIS)

Ohshima, Suguru; Nomura, Kazutoshi; Hirano, Mako; Hashimoto, Noburo; Fukumoto, Tetsuya; Katahira, Kazuhiro

1998-01-01

MRI of the knee is a useful method for diagnosing meniscal tears. Although the spin echo method is usually used for diagnosing meniscal tears, we examined the utility of thin slice scan with the three-dimensional method. We reviewed 70 menisci in which arthroscopic findings were confirmed. In this series, sensitivity was 90.9% for medial meniscal injuries and 68.8% for lateral meniscal injuries. There were 3 meniscal tears in which we could not detect tears on preoperative MRI. We could find tears in two of these cases when re-evaluated using the same MRI. In conclusion, we can get the same diagnostic rate with the three-dimensional method compared with the spin echo method. Scan time of the three-dimensional method is 3 minutes, on the other hand that of spin echo method in 17 minutes. This slice scan with three-dimensional method is useful for screening meniscal injuries before arthroscopy. (author)

Multiattribute utility theory without expected utility foundations

NARCIS (Netherlands)

Wakker, P.P.; Miyamoto, J.

1996-01-01

Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities.

Multiattribute Utility Theory without Expected Utility Foundations

NARCIS (Netherlands)

Stiggelbout, A.M.; Wakker, P.P.

1995-01-01

Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities.

Thermally Activated Paramagnets from Diamagnetic Polymers of Biphenyl-3,5-diyl Bis(tert-butyl Nitroxides Carrying Methyl and Fluoro Groups at the 2’- and 5’-Positions

Directory of Open Access Journals (Sweden)

Toru Yoshitake

2016-03-01

Full Text Available Three new biradicals—2’,5’-dimethyl-, 2’-fluoro-5’-methyl-, and 5’-fluoro-2’-methyl- biphenyl-3,5-diyl bis(tert-butyl nitroxides—were synthesized. The magnetic susceptibility measurements revealed their diamagnetism below and around room temperature. The nitroxide groups are located close to each other in an intermolecular fashion to form a weakly covalent head-to-tail (NO2 ring. Biradical molecules are connected on both radical sites, constructing a diamagnetic chain. The dimethyl derivative underwent a structural phase transition at 83 °C, clarified via differential scanning calorimetry and powder X-ray diffraction, and a paramagnetic solid phase with S = 1 irreversibly appeared. The other analogues exhibited a similar irreversible upsurge of the magnetic susceptibility on heating, but the transition was characterized as the melting.

Statistical benchmarking in utility regulation: Role, standards and methods

International Nuclear Information System (INIS)

Newton Lowry, Mark; Getachew, Lullit

2009-01-01

Statistical benchmarking is being used with increasing frequency around the world in utility rate regulation. We discuss how and where benchmarking is in use for this purpose and the pros and cons of regulatory benchmarking. We then discuss alternative performance standards and benchmarking methods in regulatory applications. We use these to propose guidelines for the appropriate use of benchmarking in the rate setting process. The standards, which we term the competitive market and frontier paradigms, have a bearing on method selection. These along with regulatory experience suggest that benchmarking can either be used for prudence review in regulation or to establish rates or rate setting mechanisms directly

Multiattribute Utility Theory without Expected Utility Foundations

NARCIS (Netherlands)

J. Miyamoto (John); P.P. Wakker (Peter)

1996-01-01

textabstractMethods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities and simplifying decompositions of multiattribute

Convenient biosynthetic preparation of isomeric spin-labelled radioactive phosphatidic acids

Energy Technology Data Exchange (ETDEWEB)

Stuhne, L.; Stanacev, N.Z. (Toronto Univ., Ontario (Canada). Dept. of Clinical Biochemistry)

1982-11-01

A convenient method for the enzymatic preparation of sn-3-(2-/sup 3/H)phosphatidic acids carrying also 5-, 12-, or 16-nitroxide stearic acids, from sn-3-(2-/sup 3/H) glycerophosphate and isolated guinea pig liver microsomes, is described in detail. The procedure allows a simultaneous preparation of three spin-labelled sn-3-(2-/sup 3/H)phosphatidic acids of yields 3-3.5..mu..mol of each compound which is >99% pure in respect to the radioactivity and which contains 25 mol% of spin-labelled fatty acids. These phosphatidic acids were approximately equally distributed between the primary and the secondary hydroxyl when 12- or 16-nitroxide stearic acids were used or predominantly (75%) associated with the secondary hydroxyl of sn-3-(2-/sup 3/H)phosphatidic acid when 5-nitroxide stearic acid was present in the incubation mixture.

Method, apparatus, and system for utilizing augmented reality to improve surgery

KAUST Repository

Cali, Corrado

2016-10-13

A method, apparatus, and computer readable medium are provided for utilizing augmented reality visualization to assist surgery. An example method includes generating a three dimensional reconstruction of an image stack representing a target area of a patient, and superimposing, by a head-mounted display, a projection of the three dimensional reconstruction onto a field of view of a user. The method further includes maintaining alignment between the projection and the user\\'s actual view of the target area using a plurality of fiducial markers associated with the target area. In some embodiments, the method further includes scanning the target area to generate the image stack.

Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells

Science.gov (United States)

Burks, Scott R.; Macedo, Luciana F.; Barth, Eugene D.; Tkaczuk, Katherine H.; Martin, Stuart S.; Rosen, Gerald M.; Halpern, Howard J.; Brodie, Angela M.

2014-01-01

Electron paramagnetic resonance (EPR) imaging is an emerging modality that can detect and localize paramagnetic molecular probes (so-called spin probes) in vivo. We previously demonstrated that nitroxide spin probes can be encapsulated in liposomes at concentrations exceeding 100 mM, at which nitroxides exhibit a concentration-dependent quenching of their EPR signal that is analogous to the self-quenching of fluorescent molecules. Therefore, intact liposomes encapsulating high concentrations of nitroxides exhibit greatly attenuated EPR spectral signals, and endocytosis of such liposomes represents a cell-activated contrast-generating mechanism. After endocytosis, the encapsulated nitroxide is liberated and becomes greatly diluted in the intracellular milieu. This dequenches the nitroxides to generate a robust intracellular EPR signal. It is therefore possible to deliver a high concentration of nitroxides to cells while minimizing background signal from unendocytosed liposomes. We report here that intracellular EPR signal can be selectively generated in a specific cell type by exploiting its expression of Human Epidermal Growth Factor Receptor 2 (HER2). When targeted by anti-HER2 immunoliposomes encapsulating quenched nitroxides, Hc7 cells, which are novel HER2-overexpressing cells derived from the MCF7 breast tumor cell line, endocytose the liposomes copiously, in contrast to the parent MCF7 cells or control CV1 cells, which do not express HER2. HER2-dependent liposomal delivery enables Hc7 cells to accumulate 750 μM nitroxide intracellularly. Through the use of phantom models, we verify that this concentration of nitroxides is more than sufficient for EPR imaging, thus laying the foundation for using EPR imaging to visualize HER2-overexpressing Hc7 tumors in animals. PMID:20066490

A Method to Predict Compressor Stall in the TF34-100 Turbofan Engine Utilizing Real-Time Performance Data

Science.gov (United States)

2015-06-01

A METHOD TO PREDICT COMPRESSOR STALL IN THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE...THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE DATA THESIS Presented to the Faculty Department of Systems Engineering and...036 A METHOD TO PREDICT COMPRESSOR STALL IN THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE DATA Shuxiang ‘Albert’ Li, BS

Different methods to define utility functions yield similar results but engage different neural processes

Directory of Open Access Journals (Sweden)

Marcus Heldmann

2009-10-01

Full Text Available Although the concept of utility is fundamental to many economic theories, up to now a generally accepted method determining a subject’s utility function is not available. We investigated two methods that are used in economic sciences for describing utility functions by using response-locked event-related potentials in order to assess their neural underpinnings. For defining the certainty equivalent (CE, we used a lottery game with probabilities to win p=0.5, for identifying the subjects’ utility functions directly a standard bisection task was applied. Although the lottery tasks’ payoffs were only hypothetical, a pronounced negativity was observed resembling the error related negativity (ERN previously described in action monitoring research, but this occurred only for choices far away from the indifference point between money and lottery. By contrast, the bisection task failed to evoke an ERN irrespective of the responses’ correctness. Based on these findings we are reasoning that only decisions made in the lottery task achieved a level of subjective relevance that activates cognitive-emotional monitoring. In terms of economic sciences, our findings support the view that the bisection method is unaffected by any kind of probability valuation or other parameters related to risk and in combination with the lottery task can, therefore, be used to differentiate between payoff and probability valuation.

Apparatus and method for materials processing utilizing a rotating magnetic field

Science.gov (United States)

Muralidharan, Govindarajan; Angelini, Joseph A.; Murphy, Bart L.; Wilgen, John B.

2017-04-11

An apparatus for materials processing utilizing a rotating magnetic field comprises a platform for supporting a specimen, and a plurality of magnets underlying the platform. The plurality of magnets are configured for rotation about an axis of rotation intersecting the platform. A heat source is disposed above the platform for heating the specimen during the rotation of the plurality of magnets. A method for materials processing utilizing a rotating magnetic field comprises providing a specimen on a platform overlying a plurality of magnets; rotating the plurality of magnets about an axis of rotation intersecting the platform, thereby applying a rotating magnetic field to the specimen; and, while rotating the plurality of magnets, heating the specimen to a desired temperature.

Cost utility analysis of diagnostic method of syphilis

Directory of Open Access Journals (Sweden)

Viroj Wiwanitkit

2008-04-01

Full Text Available Presently, the diagnosis of syphilis is dependent mainly on serological tests. The most widely used screening tests for syphilis are the VDRL and the rapid plasma reagin (RPR and for confirmation, the fluorescent treponemal antibody (FTA and the treponema pallidum hemagglutination (TPHA tests. The four alternative modes for diagnosis of syphilis can be a VDRL + FTA, b VDRL + TPHA, c RPR + FTA and d RPR + TPHA. Here the author reports an evaluation of cost utility of these tests in medical practice. It is shown that the cost per accurate diagnosis with VDRL + TPH is the least expensive choice. Therefore, this alternative is the best method for serological diagnosis for syphilis, based on medical laboratory economics principles

A simple method for measuring glucose utilization of insulin-sensitive tissues by using the brain as a reference

International Nuclear Information System (INIS)

Namba, Hiroki; Nakagawa, Keiichi; Iyo, Masaomi; Fukushi, Kiyoshi; Irie, Toshiaki

1994-01-01

A simple method, without measurement of the plasma input function, to obtain semiquantitative values of glucose utilization in tissues other than the brain with radioactive deoxyglucose is reported. The brain, in which glucose utilization is essentially insensitive to plasma glucose and insulin concentrations, was used as an internal reference. The effects of graded doses of oral glucose loading (0.5, 1 and 2 mg/g body weight) on insulin-sensitive tissues (heart, muscle and fat tissue) were studied in the rat. By using the brain-reference method, dose-dependent increases in glucose utilization were clearly shown in all the insulin-sensitive tissues examined. The method seems to be of value for measurement of glucose utilization using radioactive deoxyglucose and positron emission tomography in the heart or other insulin-sensitive tissues, especially during glucose loading. (orig.)

The Temporal Effect of Training Utility Perceptions on Adopting a Trained Method: The Role of Perceived Organizational Support

Science.gov (United States)

Madera, Juan M.; Steele, Stacey T.; Beier, Margaret

2011-01-01

The current study examined the temporal effect of perceived training utility on adoption of a trained method and how perceived organizational support influences the relationship between perceived training utility perceptions and adoption of a trained method. With the use of a correlational-survey-based design, this longitudinal study required…

Trace and low concentration co2 removal methods and apparatus utilizing metal organic frameworks

KAUST Repository

Eddaoudi, Mohamed

2016-03-10

In general, this disclosure describes techniques for removing trace and low concentration CO2 from fluids using SIFSIX-n-M MOFs, wherein n is at least two and M is a metal. In some embodiments, the metal is zinc or copper. Embodiments include devices comprising SIFSIX-n-M MOFs for removing CO2 from fluids. In particular, embodiments relate to devices and methods utilizing SIFSIX-n-M MOFs for removing CO2 from fluids, wherein CO2 concentration is trace. Methods utilizing SIFSIX-n-M MOFs for removing CO2 from fluids can occur in confined spaces. SIFSIX-n-M MOFs can comprise bidentate organic ligands. In a specific embodiment, SIFSIX-n-M MOFs comprise pyrazine or dipryidilacetylene ligands.

Growth and structure of rapid thermal silicon oxides and nitroxides studied by spectroellipsometry and Auger electron spectroscopy

Science.gov (United States)

Gonon, N.; Gagnaire, A.; Barbier, D.; Glachant, A.

1994-11-01

Rapid thermal oxidation of Czochralski-grown silicon in either O2 or N2O atmospheres have been studied using spectroellipsometry and Auger electron spectroscopy. Multiwavelength ellipsometric data were processed in order to separately derive the thickness and refractive indexes of rapid thermal dielectrics. Results revealed a significant increase of the mean refractive index as the film thickness falls below 20 nm for both O2 or N2O oxidant species. A multilayer structure including an about 0.3-nm-thick interfacial region of either SiO(x) or nitroxide in the case of O2 and N2O growth, respectively, followed by a densified SiO2 layer, was found to accurately fit the experimental data. The interfacial region together with the densified state of SiO2 close to the interface suggest a dielectric structure in agreement with the continuous random network model proposed for classical thermal oxides. Auger electron spectroscopy analysis confirmed the presence of noncrystalline Si-Si bonds in the interfacial region, mostly in the case of thin oxides grown in O2. It was speculated that the initial fast growth regime was due to a transient oxygen supersaturation in the interfacial region. Besides, the self-limiting growth in N2O was confirmed and explained in agreement with several recently published data, by the early formation of a very thin nitride or oxynitride membrane in the highly densified oxide beneath the interface. The beneficial effect of direct nitrogen incorporation by rapid thermal oxidation in N2O instead of O2 for the electrical behavior of metal-oxide-semiconductor capacitors is likely a better SiO2/Si lattice accommodation through the reduction of stresses and Si-Si bonds in the interfacial region of the dielectric.

Geochronology and geochemistry by nuclear tracks method: some utilization examples in geologic applied

International Nuclear Information System (INIS)

Poupeau, G.; Soliani Junior, E.

1988-01-01

This article discuss some applications of the 'nuclear tracks method' in geochronology, geochemistry and geophysic. In geochronology, after rapid presentation of the dating principles by 'Fission Track' and the kinds of geological events mensurable by this method, is showed some application in metallogeny and in petroleum geolocy. In geochemistry the 'fission tracks' method utilizations are related with mining prospecting and uranium prospecting. In geophysics an important application is the earthquake prevision, through the Ra 222 emanations continous control. (author) [pt

4D CAD Based Method for Supporting Coordination of Urban Subsurface Utility Projects

NARCIS (Netherlands)

olde Scholtenhuis, Léon Luc; Hartmann, T.; Doree, Andries G.

Coordinators of inner city utility construction works face increasing difficulty in managing their projects due to tight physical restrictions, strict deadlines and growing stakeholder fragmentation. This paper therefore presents a 4D CAD based coordination method that supports project plan scoping,

Do sampling methods differ in their utility for ecological monitoring? Comparison of line-point intercept, grid-point intercept, and ocular estimate methods

Science.gov (United States)

This study compared the utility of three sampling methods for ecological monitoring based on: interchangeability of data (rank correlations), precision (coefficient of variation), cost (minutes/transect), and potential of each method to generate multiple indicators. Species richness and foliar cover...

Double-label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization

Energy Technology Data Exchange (ETDEWEB)

Redies, C; Diksic, M; Evans, A C; Gjedde, A; Yamamoto, Y L

1987-08-01

A new double-label autoradiographic glucose analog method for the sequential measurement of altered regional cerebral metabolic rates for glucose in the same animal is presented. This method is based on the sequential injection of two boluses of glucose tracer labeled with two different isotopes (short-lived /sup 18/F and long-lived /sup 3/H, respectively). An operational equation is derived which allows the determination of glucose utilization for the time period before the injection of the second tracer; this equation corrects for accumulation and loss of the first tracer from the metabolic pool occurring after the injection of the second tracer. An error analysis of this operational equation is performed. The double-label deoxyglucose method is validated in the primary somatosensory (''barrel'') cortex of the anesthetized rat. Two different rows of whiskers were stimulated sequentially in each rat; the two periods of stimulation were each preceded by an injection of glucose tracer. After decapitation, dried brain slices were first exposed, in direct contact, to standard X-ray film and then to uncoated, ''tritium-sensitive'' film. Results show that the double-label deoxyglucose method proposed in this paper allows the quantification and complete separation of glucose utilization patterns elicited by two different stimulations sequentially applied in the same animal.

Three methods to monitor utilization of healthcare services by the poor

Directory of Open Access Journals (Sweden)

Urni Farhana

2009-08-01

Full Text Available Abstract Background Achieving equity by way of improving the condition of the economically poor or otherwise disadvantaged is among the core goals of contemporary development paradigm. This places importance on monitoring outcome indicators among the poor. National surveys allow disaggregation of outcomes by socioeconomic status at national level and do not have statistical adequacy to provide estimates for lower level administrative units. This limits the utility of these data for programme managers to know how well particular services are reaching the poor at the lowest level. Managers are thus left without a tool for monitoring results for the poor at lower levels. This paper demonstrates that with some extra efforts community and facility based data at the lower level can be used to monitor utilization of healthcare services by the poor. Methods Data used in this paper came from two sources- Chakaria Health and Demographic Surveillance System (HDSS of ICDDR,B and from a special study conducted during 2006 among patients attending the public and private health facilities in Chakaria, Bangladesh. The outcome variables included use of skilled attendants for delivery and use of facilities. Rate-ratio, rate-difference, concentration index, benefit incidence ratio, sequential sampling, and Lot Quality Assurance Sampling were used to assess how pro-poor is the use of skilled attendants for delivery and healthcare facilities. Findings Poor are using skilled attendants for delivery far less than the better offs. Government health service facilities are used more than the private facilities by the poor. Benefit incidence analysis and sequential sampling techniques could assess the situation realistically which can be used for monitoring utilization of services by poor. The visual display of the findings makes both these methods attractive. LQAS, on the other hand, requires small fixed sample and always enables decision making. Conclusion With some

Three methods to monitor utilization of healthcare services by the poor

Science.gov (United States)

Bhuiya, Abbas; Hanifi, SMA; Urni, Farhana; Mahmood, Shehrin Shaila

2009-01-01

Background Achieving equity by way of improving the condition of the economically poor or otherwise disadvantaged is among the core goals of contemporary development paradigm. This places importance on monitoring outcome indicators among the poor. National surveys allow disaggregation of outcomes by socioeconomic status at national level and do not have statistical adequacy to provide estimates for lower level administrative units. This limits the utility of these data for programme managers to know how well particular services are reaching the poor at the lowest level. Managers are thus left without a tool for monitoring results for the poor at lower levels. This paper demonstrates that with some extra efforts community and facility based data at the lower level can be used to monitor utilization of healthcare services by the poor. Methods Data used in this paper came from two sources- Chakaria Health and Demographic Surveillance System (HDSS) of ICDDR,B and from a special study conducted during 2006 among patients attending the public and private health facilities in Chakaria, Bangladesh. The outcome variables included use of skilled attendants for delivery and use of facilities. Rate-ratio, rate-difference, concentration index, benefit incidence ratio, sequential sampling, and Lot Quality Assurance Sampling were used to assess how pro-poor is the use of skilled attendants for delivery and healthcare facilities. Findings Poor are using skilled attendants for delivery far less than the better offs. Government health service facilities are used more than the private facilities by the poor. Benefit incidence analysis and sequential sampling techniques could assess the situation realistically which can be used for monitoring utilization of services by poor. The visual display of the findings makes both these methods attractive. LQAS, on the other hand, requires small fixed sample and always enables decision making. Conclusion With some extra efforts monitoring of the

Poly(methacrylic acid-ran-2-vinylpyridine Statistical Copolymer and Derived Dual pH-Temperature Responsive Block Copolymers by Nitroxide-Mediated Polymerization

Directory of Open Access Journals (Sweden)

Milan Marić

2017-02-01

Full Text Available Nitroxide-mediated polymerization using the succinimidyl ester functional unimolecular alkoxyamine initiator (NHS-BlocBuilder was used to first copolymerize tert-butyl methacrylate/2-vinylpyridine (tBMA/2VP with low dispersity (Đ = 1.30–1.41 and controlled growth (linear number average molecular Mn versus conversion, Mn = 3.8–10.4 kg·mol−1 across a wide composition of ranges (initial mol fraction 2VP, f2VP,0 = 0.10–0.90. The resulting statistical copolymers were first de-protected to give statistical polyampholytic copolymers comprised of methacrylic acid/2VP (MAA/2VP units. These copolymers exhibited tunable water-solubility due to the different pKas of the acidic MAA and basic 2VP units; being soluble at very low pH < 3 and high pH > 8. One of the tBMA/2VP copolymers was used as a macroinitiator for a 4-acryloylmorpholine/4-acryloylpiperidine (4AM/4AP mixture, to provide a second block with thermo-responsive behavior with tunable cloud point temperature (CPT, depending on the ratio of 4AM:4AP. Dynamic light scattering of the block copolymer at various pHs (3, 7 and 10 as a function of temperature indicated a rapid increase in particle size >2000 nm at 22–27 °C, corresponding to the 4AM/4AP segment’s thermos-responsiveness followed by a leveling in particle size to about 500 nm at higher temperatures.

[Series: Utilization of Differential Equations and Methods for Solving Them in Medical Physics (1)].

Science.gov (United States)

Murase, Kenya

2014-01-01

Utilization of differential equations and methods for solving them in medical physics are presented. First, the basic concept and the kinds of differential equations were overviewed. Second, separable differential equations and well-known first-order and second-order differential equations were introduced, and the methods for solving them were described together with several examples. In the next issue, the symbolic and series expansion methods for solving differential equations will be mainly introduced.

Verdazyl-ribose: A new radical for solid-state dynamic nuclear polarization at high magnetic field

Science.gov (United States)

Thurber, Kent R.; Le, Thanh-Ngoc; Changcoco, Victor; Brook, David J. R.

2018-04-01

Solid-state dynamic nuclear polarization (DNP) using the cross-effect relies on radical pairs whose electron spin resonance (ESR) frequencies differ by the nuclear magnetic resonance (NMR) frequency. We measure the DNP provided by a new water-soluble verdazyl radical, verdazyl-ribose, under both magic-angle spinning (MAS) and static sample conditions at 9.4 T, and compare it to a nitroxide radical, 4-hydroxy-TEMPO. We find that verdazyl-ribose is an effective radical for cross-effect DNP, with the best relative results for a non-spinning sample. Under non-spinning conditions, verdazyl-ribose provides roughly 2× larger 13C cross-polarized (CP) NMR signal than the nitroxide, with similar polarization buildup times, at both 29 K and 76 K. With MAS at 7 kHz and 1.5 W microwave power, the verdazyl-ribose does not provide as much DNP as the nitroxide, with the verdazyl providing less NMR signal and a longer polarization buildup time. When the microwave power is decreased to 30 mW with 5 kHz MAS, the two types of radical are comparable, with the verdazyl-doped sample having a larger NMR signal which compensates for its longer polarization buildup time. We also present electron spin relaxation measurements at Q-band (1.2 T) and ESR lineshapes at 1.2 and 9.4 T. Most notably, the verdazyl radical has a longer T1e than the nitroxide (9.9 ms and 1.3 ms, respectively, at 50 K and 1.2 T). The verdazyl electron spin lineshape is significantly affected by the hyperfine coupling to four 14N nuclei, even at 9.4 T. We also describe 3000-spin calculations to illustrate the DNP potential of possible radical pairs: verdazyl-verdazyl, verdazyl-nitroxide, or nitroxide-nitroxide pairs. These calculations suggest that the verdazyl radical at 9.4 T has a narrower linewidth than optimal for cross-effect DNP using verdazyl-verdazyl pairs. Because of the hyperfine coupling contribution to the electron spin linewidth, this implies that DNP using the verdazyl radical would improve at lower

Verdazyl-ribose: A new radical for solid-state dynamic nuclear polarization at high magnetic field.

Science.gov (United States)

Thurber, Kent R; Le, Thanh-Ngoc; Changcoco, Victor; Brook, David J R

2018-04-01

Solid-state dynamic nuclear polarization (DNP) using the cross-effect relies on radical pairs whose electron spin resonance (ESR) frequencies differ by the nuclear magnetic resonance (NMR) frequency. We measure the DNP provided by a new water-soluble verdazyl radical, verdazyl-ribose, under both magic-angle spinning (MAS) and static sample conditions at 9.4 T, and compare it to a nitroxide radical, 4-hydroxy-TEMPO. We find that verdazyl-ribose is an effective radical for cross-effect DNP, with the best relative results for a non-spinning sample. Under non-spinning conditions, verdazyl-ribose provides roughly 2× larger 13 C cross-polarized (CP) NMR signal than the nitroxide, with similar polarization buildup times, at both 29 K and 76 K. With MAS at 7 kHz and 1.5 W microwave power, the verdazyl-ribose does not provide as much DNP as the nitroxide, with the verdazyl providing less NMR signal and a longer polarization buildup time. When the microwave power is decreased to 30 mW with 5 kHz MAS, the two types of radical are comparable, with the verdazyl-doped sample having a larger NMR signal which compensates for its longer polarization buildup time. We also present electron spin relaxation measurements at Q-band (1.2 T) and ESR lineshapes at 1.2 and 9.4 T. Most notably, the verdazyl radical has a longer T 1e than the nitroxide (9.9 ms and 1.3 ms, respectively, at 50 K and 1.2 T). The verdazyl electron spin lineshape is significantly affected by the hyperfine coupling to four 14 N nuclei, even at 9.4 T. We also describe 3000-spin calculations to illustrate the DNP potential of possible radical pairs: verdazyl-verdazyl, verdazyl-nitroxide, or nitroxide-nitroxide pairs. These calculations suggest that the verdazyl radical at 9.4 T has a narrower linewidth than optimal for cross-effect DNP using verdazyl-verdazyl pairs. Because of the hyperfine coupling contribution to the electron spin linewidth, this implies that DNP using the verdazyl

Utilization of net energy analysis as a method of evaluating energy systems

International Nuclear Information System (INIS)

Lee, Gi Won; Cho, Joo Hyun; Hah, Yung Joon

1994-01-01

It can be said that the upturn of Korean nuclear power program started in early 70's while future plants for the construction of new nuclear power plants virtually came to a halt in United States since the late 70's. It is projected that power plant systems from combination of nuclear and coal fired types might shift to all coal fired type in U.S., considering the current U.S. trend of construction on the new plants. However, with the depletion of natural resources, it may be desirable to understand the utilization of two competitive utility technologies in terms of invested energy. Presented in this paper is a method of comparing two energy systems in terms of energy investment and a brief result from energy economic analysis of nuclear power plant and coal fired steam power plant to illustrate the methodology. The method of comparison is Net Energy Analysis (NEA). In doing so, Input-Output Analysis (lOA) among industries and commodities is done. Using these information, net energy ratios are calculated and compared. Although NEA does not offer conclusive solution, it can be used as a screening process in decision making

Quantitative determination of the crystalline phases of the ceramic materials utilizing the Rietveld method

International Nuclear Information System (INIS)

Kniess, C.T.; Prates, P.B.; Lima, J.C. de; Kuhnen, N.C.; Riella, H.G.; Maliska, A.M.

2009-01-01

Ceramic materials have properties defined by their chemical and micro-structural composition. The quantification of the crystalline phases is a fundamental stage in the determination of the structure, properties and applications of a ceramic material. Within this context, this study aims is the quantitative determination of the crystalline phases of the ceramic materials developed with addition of mineral coal bottom ash, utilizing the X ray diffraction technique, through the method proposed by Rietveld. For the formulation of the ceramic mixtures a {3,3} simplex-lattice design was used, giving ten formulations of three components (two different types of clays and coal bottom ash). The crystalline phases identified in the ceramic materials after sintering at 1150 deg C during two hours are: quartz, tridimite, mullite and hematite. The proposed methodology utilizing the Rietveld method for the quantification relating to crystalline phases of the materials was shown to be adequate and efficient. (author)

A self-reference PRF-shift MR thermometry method utilizing the phase gradient

International Nuclear Information System (INIS)

Langley, Jason; Potter, William; Phipps, Corey; Zhao Qun; Huang Feng

2011-01-01

In magnetic resonance (MR) imaging, the most widely used and accurate method for measuring temperature is based on the shift in proton resonance frequency (PRF). However, inter-scan motion and bulk magnetic field shifts can lead to inaccurate temperature measurements in the PRF-shift MR thermometry method. The self-reference PRF-shift MR thermometry method was introduced to overcome such problems by deriving a reference image from the heated or treated image, and approximates the reference phase map with low-order polynomial functions. In this note, a new approach is presented to calculate the baseline phase map in self-reference PRF-shift MR thermometry. The proposed method utilizes the phase gradient to remove the phase unwrapping step inherent to other self-reference PRF-shift MR thermometry methods. The performance of the proposed method was evaluated using numerical simulations with temperature distributions following a two-dimensional Gaussian function as well as phantom and in vivo experimental data sets. The results from both the numerical simulations and experimental data show that the proposed method is a promising technique for measuring temperature. (note)

Platelet function testing: methods of assessment and clinical utility.

LENUS (Irish Health Repository)

Mylotte, Darren

2012-02-01

Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.

Platelet function testing: methods of assessment and clinical utility.

LENUS (Irish Health Repository)

Mylotte, Darren

2011-01-01

Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.

Exergy and exergoeconomic analysis of a petroleum refinery utilities plant using the condensing to power method

Energy Technology Data Exchange (ETDEWEB)

Mendes da Silva, Julio Augusto; Pellegrini, Luiz Felipe; Oliveira Junior, Silvio [Polytechnic School of the University of Sao Paulo, SP (Brazil)], e-mails: jams@usp.br, luiz.pellegrini@usp.br, soj@usp.br; Plaza, Claudio; Rucker, Claudio [Petrobras - Petroleo Brasileiro S.A., Rio de Janeiro, RJ (Brazil)], e-mails: claudioplaza@petrobras.com.br, rucker@petrobras.com.br

2010-07-01

In this paper a brief description of the main processes present in a modern high capacity refinery is done. The methodology used to evaluate, through exergy analysis, the performance of the refinery's utilities plant since it is responsible for a very considerable amount of the total exergy destruction in a refinery is presented. The utilities plant products: steam, electricity, shaft power and high pressure water had their exergy unit cost determined using exergoeconomic approach. A simple and effective method called condensing to power was used to define the product of the condensers in exergy basis. Using this method it is possible to define the product of the condenser without the use of negentropy concept nor the aggregation of condensers to the steam turbines. By using this new approach, the costs obtained for the plant's products are exactly the same costs obtained when the condenser is aggregated to the steam turbine but with the advantage that the information about the stream between condenser and the steam turbine is not lost and the condenser can be evaluated singly. The analysis shows that the equipment where attention and resources should be focused are the boilers followed by the gas turbine, that together, are responsible for 80% of total exergy destruction in the utilities plant. The total exergy efficiency found for the utilities plant studied is 35% while more than 280 MW of exergy is destroyed in the utilities processes. (author)

Utility portfolio diversification

International Nuclear Information System (INIS)

Griffes, P.H.

1990-01-01

This paper discusses portfolio analysis as a method to evaluate utility supply decisions. Specifically a utility is assumed to increase the value of its portfolio of assets whenever it invests in a new supply technology. This increase in value occurs because the new asset either enhances the return or diversifies the risks of the firm's portfolio of assets. This evaluation method is applied to two supply innovations in the electric utility industry: jointly-owned generating plants and supply contracts with independent power producers (IPPs)

Creating Critical Conversations: Investigating the Utility of Socratic Dialogues in Elementary Social Studies Methods

Science.gov (United States)

Buchanan, Lisa Brown

2012-01-01

This article explores the utility of Socratic dialogues in the elementary social studies methods course. Findings include preservice teachers' behaviors during dialogues, perceived strengths and challenges of using Socratic dialogues in teacher education, and the impact on student learning. Challenges and apprehensions encountered by the teacher…

A method of short range system analysis for nuclear utilities

International Nuclear Information System (INIS)

Eng, R.; Mason, E.A.; Benedict, M.

1976-01-01

An optimization procedure has been formulated and tested that is capable of solving for the optimal generation schedule of several nuclear power reactors in an electric power utility system, under short-range, resource-limited, conditions. The optimization procedure utilizes a new concept called the Opportunity Cost of Nuclear Power (OCNP) to optimally assign the resource-limited nuclear energy to the different weeks and hours in the short-range planning horizon. OCNP is defined as the cost of displaced energy when optimally distributed nuclear energy is marginally increased. Under resource-limited conditions, the short-range 'value' of nuclear power to a utility system is not its actual generation cost, but the cost of the next best alternative supply of energy, the OCNP. OCNP is a function of a week's system reserve capacity, the system's economic loading order, the customer demand function, and the nature of the available utility system generating units. The optimized OCNP value of the short-range planning period represents the utility's short-range energy replacement cost incurred when selling nuclear energy to a neighbouring utility. (author)

The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis

Directory of Open Access Journals (Sweden)

Dmitriy Vladimirovich Goryachev

2010-01-01

The values of the utility index calculated by TTO failed to correlate with those of HAQ and EQ-5D. The disease duration was unrelated to the values of the utility index calculated by any of the methods used. The association of TTO index was found only for VAS-GH "thermometer". Conclusion. EQ-5D index and VAS-GH are the methods of choice in determining health utility for a clinicoeconomic analysis in patients with RA.

A proposed method for determining long term optimum utilization ...

African Journals Online (AJOL)

Application of utilization intensity as an experimental variable by the use of the pasture disc meter and the put- and take technique is recommended as an alternative to stocking rate experiments. Utilization intensity allows stocking rate to be used as a measure of pasture productivity and consequently the relationship ...

Method and apparatus for generating and utilizing a compound plasma configuration

International Nuclear Information System (INIS)

Koloc, P.M.

1977-01-01

A method and apparatus for generating and utilizing a compound plasma configuration is disclosed. The plasma configuration includes a central toroidal plasma with electrical currents surrounded by a generally ellipsoidal mantle of ionized particles or electrically conducting matter. The preferred methods of forming this compound plasma configuration include the steps of forming a helical ionized path in a gaseous medium and simultaneously discharging a high potential through the ionized path to produce a helical or heliform current which collapses on itself to produce a toroidal current, or generating a toroidal plasmoid, supplying magnetic energy to the plasmoid, and applying fluid pressure external to the plasmoid. The apparatus of the present invention includes a pressure chamber wherein the compound plasma configuration can be isolated or compressed by fluid or other forms of mechanical or magnetic pressure. 47 claims, 10 figures

Analysis method and utilization mechanism of the overall value of EV charging

International Nuclear Information System (INIS)

Guo, Chunlin; Chan, Ching Chuen

2015-01-01

Highlights: • Analysis on the overall value of EV charging from a viewpoint of system. • An analytical model of the overall value of EV charging was presented. • A model was proposed to calculate the value of emission reduction by EV. • A model to evaluate the improvement in new energy utilization was given. • A utilization mechanism apt to overall optimization was proposed. - Abstract: Electric Vehicle (EV) can save energy while reducing emissions and has thus attracted the attention of both academics and industry. The cost and benefit of charging are one of the key issues in relation to EV development that has been researched extensively. But many studies are carried out from a viewpoint of some local entities rather than a global system, focus on specific types or aspects of EV charging, or use mixed models that can only be computed by computer simulation and lack physical transparency. This paper illuminated that it is necessary to consider the value of EV charging on a system scale. In order to achieve this, it presents an analytical model for analyzing the overall value of EVs, an analysis model to evaluate the reduction of pollutions relevant to photovoltaic power, and a model to transfer the intrinsic savings of wind power to the off-peak charging loads. It is estimated that EV charging has a significant positive value, providing the basis for enhanced EV subsidies. Accordingly, a utilization mechanism apt to optimize globally is proposed, upon which sustainable business models can be formed by providing adequate support, including the implementation of a peak–valley tariff, charging subsidies and one-time battery subsidies. This utilization mechanism, by taking full advantage of the operation system of power utilities to provide basic support and service, may provide new approaches to the development of EVs. The method proposed here is of important value for the systematic considerations about EV development and maybe can help broaden the

The synthesis and spectroscopic study of stable free radicals related to piperidine-n-oxyl, including a stable bi-radical

International Nuclear Information System (INIS)

Briere, R.

1965-07-01

A new synthesis of di-tert-butyl nitroxide using the reaction between tert-butyl magnesium chloride and nitro-tert-butane is presented in the first section. Synthesis and investigation of stable free piperidine-N-oxyl radicals are described in the second section. All these nitroxides have been characterised by their I. R., U. V. and E. P. R. absorption spectra. The final section contains a description of the synthesis of a stable bi-radical of the nitroxide type by condensation of 2,2, 6, 6-tetramethyl-piperid-4-one-l-oxyl with hydrazine. (author) [fr

A bottom-up method to develop pollution abatement cost curves for coal-fired utility boilers

Science.gov (United States)

This paper illustrates a new method to create supply curves for pollution abatement using boiler-level data that explicitly accounts for technology costs and performance. The Coal Utility Environmental Cost (CUECost) model is used to estimate retrofit costs for five different NO...

Method of utilization of alum shales

Energy Technology Data Exchange (ETDEWEB)

Dahlerus, C G

1908-07-04

A procedure - by means of reducing smelting of bituminous alum shales in a closed furnace process with or without the use of additional fuel and without adding lime or other slag-forming material - to utilize the hydrocarbons and tar oils formed, and likewise the alkali, nitrogen, and sulfur compositions is given. This is accomplished by making these products follow the furnace gases, and later separating them from the gases by cooling for condensation. The patent contains one more claim.

Evaluation of the efficiency and utility of recombinant enzyme-free seamless DNA cloning methods

Directory of Open Access Journals (Sweden)

Ken Motohashi

2017-03-01

Full Text Available Simple and low-cost recombinant enzyme-free seamless DNA cloning methods have recently become available. In vivo Escherichia coli cloning (iVEC can directly transform a mixture of insert and vector DNA fragments into E. coli, which are ligated by endogenous homologous recombination activity in the cells. Seamless ligation cloning extract (SLiCE cloning uses the endogenous recombination activity of E. coli cellular extracts in vitro to ligate insert and vector DNA fragments. An evaluation of the efficiency and utility of these methods is important in deciding the adoption of a seamless cloning method as a useful tool. In this study, both seamless cloning methods incorporated inserting DNA fragments into linearized DNA vectors through short (15–39 bp end homology regions. However, colony formation was 30–60-fold higher with SLiCE cloning in end homology regions between 15 and 29 bp than with the iVEC method using DH5α competent cells. E. coli AQ3625 strains, which harbor a sbcA gene mutation that activates the RecE homologous recombination pathway, can be used to efficiently ligate insert and vector DNA fragments with short-end homology regions in vivo. Using AQ3625 competent cells in the iVEC method improved the rate of colony formation, but the efficiency and accuracy of SLiCE cloning were still higher. In addition, the efficiency of seamless cloning methods depends on the intrinsic competency of E. coli cells. The competency of chemically competent AQ3625 cells was lower than that of competent DH5α cells, in all cases of chemically competent cell preparations using the three different methods. Moreover, SLiCE cloning permits the use of both homemade and commercially available competent cells because it can use general E. coli recA− strains such as DH5α as host cells for transformation. Therefore, between the two methods, SLiCE cloning provides both higher efficiency and better utility than the iVEC method for seamless DNA plasmid

Factors associated with utilization of long-acting and permanent contraceptive methods among women who have decided not to have more children in Gondar city.

Science.gov (United States)

Zenebe, Chernet Baye; Adefris, Mulat; Yenit, Melaku Kindie; Gelaw, Yalemzewod Assefa

2017-09-06

Despite the fact that long acting family planning methods reduce population growth and improve maternal health, their utilization remains poor. Therefore, this study assessed the prevalence of long acting and permanent family planning method utilization and associated factors among women in reproductive age groups who have decided not to have more children in Gondar city, northwest Ethiopia. An institution based cross-sectional study was conducted from August to October, 2015. Three hundred seventeen women who have decided not to have more children were selected consecutively into the study. A structured and pretested questionnaire was used to collect data. Both bivariate and multi-variable logistic regressions analyses were used to identify factors associated with utilization of long acting and permanent family planning methods. The multi-variable logistic regression analysis was used to investigate factors associated with the utilization of long acting and permanent family planning methods. The Adjusted Odds Ratio (AOR) with the corresponding 95% Confidence Interval (CI) was used to show the strength of associations, and variables with a P-value of <0.05 were considered statistically significant. In this study, the overall prevalence of long acting and permanent contraceptive (LAPCM) method utilization was 34.7% (95% CI: 29.5-39.9). According to the multi-variable logistic regression analysis, utilization of long acting and permanent contraceptive methods was significantly associated with women who had secondary school, (AOR: 2279, 95% CI: 1.17, 4.44), college, and above education (AOR: 2.91, 95% CI: 1.36, 6.24), history of previous utilization (AOR: 3.02, 95% CI: 1.69, 5.38), and information about LAPCM (AOR: 8.85, 95% CI: 2.04, 38.41). In this study the prevalence of long acting and permanent family planning method utilization among women who have decided not to have more children was high compared with previous studies conducted elsewhere. Advanced educational

Tank Operations Contract Construction Management Methodology. Utilizing The Agency Method Of Construction Management

International Nuclear Information System (INIS)

Lesko, K.F.; Berriochoa, M.V.

2010-01-01

Washington River Protection Solutions, LLC (WRPS) has faced significant project management challenges in managing Davis-Bacon construction work that meets contractually required small business goals. The unique challenge is to provide contracting opportunities to multiple small business constructioin subcontractors while performing high hazard work in a safe and productive manner. Previous to the WRPS contract, construction work at the Hanford Tank Farms was contracted to large companies, while current Department of Energy (DOE) Contracts typically emphasize small business awards. As an integral part of Nuclear Project Management at Hanford Tank Farms, construction involves removal of old equipment and structures and installation of new infrastructure to support waste retrieval and waste feed delivery to the Waste Treatment Plant. Utilizing the optimum construction approach ensures that the contractors responsible for this work are successful in meeting safety, quality, cost and schedule objectives while working in a very hazardous environment. This paper descirbes the successful transition from a traditional project delivery method that utilized a large business general contractor and subcontractors to a new project construction management model that is more oriented to small businesses. Construction has selected the Agency Construction Management Method (John E Schaufelberger, Len Holm, 'Management of Construction Projects, A Constructor's Perspective', University of Washington, Prentice Hall 2002). This method was implemented in the first quarter of Fiscal Year 2009 (FY2009), where Construction Management is performed by substantially home office resources from the URS Northwest Office in Richland, Washington. The Agency Method has allowed WRPS to provide proven Construction Managers and Field Leads to mentor and direct small business contractors, thus providing expertise and assurance of a successful project. Construction execution contracts are subcontracted

TANK OPERATIONS CONTRACT CONSTRUCTION MANAGEMENT METHODOLOGY UTILIZING THE AGENCY METHOD OF CONSTRUCTION MANAGEMENT

Energy Technology Data Exchange (ETDEWEB)

LESKO KF; BERRIOCHOA MV

2010-02-26

Washington River Protection Solutions, LLC (WRPS) has faced significant project management challenges in managing Davis-Bacon construction work that meets contractually required small business goals. The unique challenge is to provide contracting opportunities to multiple small business constructioin subcontractors while performing high hazard work in a safe and productive manner. Previous to the WRPS contract, construction work at the Hanford Tank Farms was contracted to large companies, while current Department of Energy (DOE) Contracts typically emphasize small business awards. As an integral part of Nuclear Project Management at Hanford Tank Farms, construction involves removal of old equipment and structures and installation of new infrastructure to support waste retrieval and waste feed delivery to the Waste Treatment Plant. Utilizing the optimum construction approach ensures that the contractors responsible for this work are successful in meeting safety, quality, cost and schedule objectives while working in a very hazardous environment. This paper descirbes the successful transition from a traditional project delivery method that utilized a large business general contractor and subcontractors to a new project construction management model that is more oriented to small businesses. Construction has selected the Agency Construction Management Method (John E Schaufelberger, Len Holm, "Management of Construction Projects, A Constructor's Perspective", University of Washington, Prentice Hall 2002). This method was implemented in the first quarter of Fiscal Year 2009 (FY2009), where Construction Management is performed by substantially home office resources from the URS Northwest Office in Richland, Washington. The Agency Method has allowed WRPS to provide proven Construction Managers and Field Leads to mentor and direct small business contractors, thus providing expertise and assurance of a successful project. Construction execution contracts are

Methods in pharmacoepidemiology: a review of statistical analyses and data reporting in pediatric drug utilization studies.

Science.gov (United States)

Sequi, Marco; Campi, Rita; Clavenna, Antonio; Bonati, Maurizio

2013-03-01

To evaluate the quality of data reporting and statistical methods performed in drug utilization studies in the pediatric population. Drug utilization studies evaluating all drug prescriptions to children and adolescents published between January 1994 and December 2011 were retrieved and analyzed. For each study, information on measures of exposure/consumption, the covariates considered, descriptive and inferential analyses, statistical tests, and methods of data reporting was extracted. An overall quality score was created for each study using a 12-item checklist that took into account the presence of outcome measures, covariates of measures, descriptive measures, statistical tests, and graphical representation. A total of 22 studies were reviewed and analyzed. Of these, 20 studies reported at least one descriptive measure. The mean was the most commonly used measure (18 studies), but only five of these also reported the standard deviation. Statistical analyses were performed in 12 studies, with the chi-square test being the most commonly performed test. Graphs were presented in 14 papers. Sixteen papers reported the number of drug prescriptions and/or packages, and ten reported the prevalence of the drug prescription. The mean quality score was 8 (median 9). Only seven of the 22 studies received a score of ≥10, while four studies received a score of statistical methods and reported data in a satisfactory manner. We therefore conclude that the methodology of drug utilization studies needs to be improved.

Resolving inconsistencies in utility measurement under risk: Tests of generalizations of expected utility

OpenAIRE

Han Bleichrodt; José María Abellán-Perpiñan; JoséLuis Pinto; Ildefonso Méndez-Martínez

2005-01-01

This paper explores inconsistencies that occur in utility measurement under risk when expected utility theory is assumed and the contribution that prospect theory and some other generalizations of expected utility can make to the resolution of these inconsistencies. We used five methods to measure utilities under risk and found clear violations of expected utility. Of the theories studied, prospect theory was the most consistent with our data. The main improvement of prospect theory over expe...

Methods for Analyzing the Benefits and Costs of Distributed Photovoltaic Generation to the U.S. Electric Utility System

Energy Technology Data Exchange (ETDEWEB)

Denholm, P.; Margolis, R.; Palmintier, B.; Barrows, C.; Ibanez, E.; Bird, L.; Zuboy, J.

2014-09-01

This report outlines the methods, data, and tools that could be used at different levels of sophistication and effort to estimate the benefits and costs of DGPV. In so doing, we identify the gaps in current benefit-cost-analysis methods, which we hope will inform the ongoing research agenda in this area. The focus of this report is primarily on benefits and costs from the utility or electricity generation system perspective. It is intended to provide useful background information to utility and regulatory decision makers and their staff, who are often being asked to use or evaluate estimates of the benefits and cost of DGPV in regulatory proceedings. Understanding the technical rigor of the range of methods and how they might need to evolve as DGPV becomes a more significant contributor of energy to the electricity system will help them be better consumers of this type of information. This report is also intended to provide information to utilities, policy makers, PV technology developers, and other stakeholders, which might help them maximize the benefits and minimize the costs of integrating DGPV into a changing electricity system.

A novel method of utilizing permeable reactive kiddle (PRK) for the remediation of acid mine drainage.

Science.gov (United States)

Lee, Woo-Chun; Lee, Sang-Woo; Yun, Seong-Taek; Lee, Pyeong-Koo; Hwang, Yu Sik; Kim, Soon-Oh

2016-01-15

Numerous technologies have been developed and applied to remediate AMD, but each has specific drawbacks. To overcome the limitations of existing methods and improve their effectiveness, we propose a novel method utilizing permeable reactive kiddle (PRK). This manuscript explores the performance of the PRK method. In line with the concept of green technology, the PRK method recycles industrial waste, such as steel slag and waste cast iron. Our results demonstrate that the PRK method can be applied to remediate AMD under optimal operational conditions. Especially, this method allows for simple installation and cheap expenditure, compared with established technologies. Copyright © 2015 Elsevier B.V. All rights reserved.

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

NARCIS (Netherlands)

Rwigema, Jean-Claude M.; Beck, Barbara; Wang, Wei; Doemling, Alexander; Epperly, Michael W.; Shields, Donna; Goff, Julie P.; Franicola, Darcy; Dixon, Tracy; Frantz, Marie-Céline; Wipf, Peter; Tyurina, Yulia; Kagan, Valerian E.; Wang, Hong; Greenberger, Joel S.

2011-01-01

Purpose: To evaluate the effectiveness of mitigation of acute ionizing radiation damage by mitochondrion-targeted small molecules. Methods and Materials: We evaluated the ability of nitroxide-linked alkene peptide isostere JP4-039, the nitric oxide synthase inhibitor-linked alkene peptide esostere

Impact of phosphate-solubilizing bacteria inoculation methods on phosphorus transformation and long-term utilization in composting.

Science.gov (United States)

Wei, Yuquan; Zhao, Yue; Fan, Yuying; Lu, Qian; Li, Mingxiao; Wei, Qingbin; Zhao, Yi; Cao, Zhenyu; Wei, Zimin

2017-10-01

This study aimed to assess the effect of phosphate-solubilizing bacteria (PSB) application and inoculation methods on rock phosphate (RP) solubilization and bacterial community during composting. The results showed that PSB inoculation in different stages of composting, especially both in the beginning and cooling stages, not only improved the diversity and abundance of PSB and bacterial community, but also distinctly increased the content of potential available phosphorus. Redundancy analysis indicated that the combined inoculation of PSB in the initial stage with higher inoculation amount and in the cooling stage with lower inoculation amount was the best way to improve the inoculation effect and increase the solubilization and utilization of RP during composting. Besides, we suggested three methods to improve phosphorus transformation and long-term utilization efficiency in composts based on biological fixation of phosphates by humic substance and phosphate-accumulating organisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

An Operationally Simple Method for Separating the Rare-Earth Elements Neodymium and Dysprosium.

Science.gov (United States)

Bogart, Justin A; Lippincott, Connor A; Carroll, Patrick J; Schelter, Eric J

2015-07-06

Rare-earth metals are critical components of electronic materials and permanent magnets. Recycling of consumer materials is a promising new source of rare earths. To incentivize recycling there is a clear need for simple methods for targeted separations of mixtures of rare-earth metal salts. Metal complexes of a tripodal nitroxide ligand [{(2-(t) BuNO)C6 H4 CH2 }3 N](3-) (TriNOx(3-) ), feature a size-sensitive aperture formed of its three η(2) -(N,O) ligand arms. Exposure of metal cations in the aperture induces a self-associative equilibrium comprising [M(TriNOx)thf]/ [M(TriNOx)]2 (M=rare-earth metal). Differences in the equilibrium constants (Keq ) for early and late metals enables simple Nd/Dy separations through leaching with a separation ratio SNd/Dy =359. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Awareness and Utilization of Family Planning Methods among ...

African Journals Online (AJOL)

deficiency Virus (HIV) infection influence the design and background Family planning is an important preventive measure against maternal and child morbidity and mortality. This study was aimed at determining the awareness and utilization of family ...

The synthesis and spectroscopic study of stable free radicals related to piperidine-n-oxyl, including a stable bi-radical; Syntheses et etudes spectroscopiques de radicaux libres piperidiniques et d'un biradical stable, du type nitroxyde

Energy Technology Data Exchange (ETDEWEB)

Briere, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires, Laboratoire de chimie organique physique

1967-06-01

A new synthesis of di-tert-butyl nitroxide using the reaction between tert-butyl magnesium chloride and nitro-tert-butane is presented in the first section. Synthesis and investigation of stable free piperidine-N-oxyl radicals are described in the second section. All these nitroxides have been characterised by their I. R., U. V. and E. P. R. absorption spectra. The final section contains a description of the synthesis of a stable bi-radical of the nitroxide type by condensation of 2,2, 6, 6-tetramethyl-piperid-4-one-l-oxyl with hydrazine. (author) [French] La premiere partie expose une nouvelle methode de synthase du di-t-butyl nitroxyde, par action d'halogenures de t-butyl magnesium sur le nitro-t-butane (Rdt maximum 45 pour cert, purete 86 pour cent). Une etude de radicaux. libres stables pipericliniques est faite dans une seconde partie. Ces composes sont obtenus par oxydation de derives de la triacetonamine. Les caracteristiques spectroscopiques ultra-violette, infra-rouge, et paramagnetique electronique de ces radicaux sont donnees. La grande inertie chimique du groupement nitroxyde a permis la syn-these d'un biradical stable par formation d'azine d'une cetone radicalaire, ce qui fait 1'objet de la troisieme partie. (auteur)

Astronomical Orientation Method Based on Lunar Observations Utilizing Super Wide Field of View

Directory of Open Access Journals (Sweden)

PU Junyu

2018-04-01

Full Text Available In this paper,astronomical orientation is achieved by observing the moon utilizing camera with super wide field of view,and formulae are deduced in detail.An experiment based on real observations verified the stability of the method.In this experiment,after 15 minutes' tracking shoots,the internal precision could be superior to ±7.5" and the external precision could approximately reach ±20".This camera-based method for astronomical orientation can change the traditional mode (aiming by human eye based on theodolite,thus lowering the requirements for operator's skill to some extent.Furthermore,camera with super wide field of view can realize the function of continuous tracking shoots on the moon without complicated servo control devices.Considering the similar existence of gravity on the moon and the earth's phase change when observed from the moon,once the technology of self-leveling is developed,this method can be extended to orientation for lunar rover by shooting the earth.

Measurement of utility.

Science.gov (United States)

Thavorncharoensap, Montarat

2014-05-01

The Quality Adjusted Life Year (QALY) is the most widely recommended health outcome measure for use in economic evaluations. The QALY gives a value to the effect of a given health intervention in terms of both quantity and quality. QALYs are calculated by multiplying the duration of time spent in a given health state, in years, by the quality of life weighted, known as utility. Utility can range from 0 (the worst health state-the equivalent of death) to 1 (the best health state-full health). This paper provides an overview of the various methods that can be used to measure utility and outlines the recommended protocol for measuring utility, as described in the Guidelines for Health Technology Assessment in Thailand (second edition). The recommendations are as follows: Wherever possible, primary data collection using EQ-5D-3L in patients using Thai value sets generated from the general public should be used. Where the EQ-5D-3L is considered inappropriate, other methods such as Standard gamble (SG), Time-trade-off (TTO), Visual analogue scale (VAS), Health Utilities Index (HUI), SF-6D, or Quality of well being (QWB) can be used. However, justification and full details on the chosen instrument should always be provided.

Inhibition of overexpression of Giα proteins and nitroxidative stress contribute to sodium nitroprusside-induced attenuation of high blood pressure in SHR.

Science.gov (United States)

Hossain, Ekhtear; Sarkar, Oli; Li, Yuan; Anand-Srivastava, Madhu B

2018-03-01

We earlier showed that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit enhanced expression of Giα proteins which was attributed to the decreased levels of nitric oxide (NO), because elevation of the intracellular levels of NO by NO donors; sodium nitroprusside (SNP) and S-Nitroso-N-acetyl-DL-penicillamine (SNAP), attenuated the enhanced expression of Giα proteins. Since the enhanced expression of Giα proteins is implicated in the pathogenesis of hypertension, the present study was undertaken to investigate if treatment of SHR with SNP could also attenuate the development of high blood pressure (BP) and explore the underlying molecular mechanisms. Intraperitoneal injection of SNP at a concentration of 0.5 mg/kg body weight twice a week for 2 weeks into SHR attenuated the high blood pressure by about 80 mmHg without affecting the BP in WKY rats. SNP treatment also attenuated the enhanced levels of superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), peroxynitrite (ONOO - ), and NADPH oxidase activity in VSMC from SHR to control levels. In addition, the overexpression of different subunits of NADPH oxidase; Nox-1, Nox-2, Nox-4, P 22phox , and P 47phox , and Giα proteins in VSMC from SHR were also attenuated by SNP treatment. On the other hand, SNP treatment augmented the decreased levels of intracellular NO, eNOS, and cGMP in VSMC from SHR. These results suggest that SNP treatment attenuates the development of high BP in SHR through the elevation of intracellular levels of cGMP and inhibition of the enhanced levels of Giα proteins and nitroxidative stress. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Methods for cellobiosan utilization

Energy Technology Data Exchange (ETDEWEB)

Linger, Jeffrey; Beckham, Gregg T.

2017-07-11

Disclosed herein are enzymes useful for the degradation of cellobiosan in materials such a pyrolysis oils. Methods of degrading cellobiosan using enzymes or organisms expressing the same are also disclosed.

Possibilities of Utilizing the Method of Analytical Hierarchy Process Within the Strategy of Corporate Social Business

Science.gov (United States)

Drieniková, Katarína; Hrdinová, Gabriela; Naňo, Tomáš; Sakál, Peter

2010-01-01

The paper deals with the analysis of the theory of corporate social responsibility, risk management and the exact method of analytic hierarchic process that is used in the decision-making processes. The Chapters 2 and 3 focus on presentation of the experience with the application of the method in formulating the stakeholders' strategic goals within the Corporate Social Responsibility (CSR) and simultaneously its utilization in minimizing the environmental risks. The major benefit of this paper is the application of Analytical Hierarchy Process (AHP).

A bottom-up method to develop pollution abatement cost curves for coal-fired utility boilers

International Nuclear Information System (INIS)

Vijay, Samudra; DeCarolis, Joseph F.; Srivastava, Ravi K.

2010-01-01

This paper illustrates a new method to create supply curves for pollution abatement using boiler-level data that explicitly accounts for technology cost and performance. The Coal Utility Environmental Cost (CUECost) model is used to estimate retrofit costs for five different NO x control configurations on a large subset of the existing coal-fired, utility-owned boilers in the US. The resultant data are used to create technology-specific marginal abatement cost curves (MACCs) and also serve as input to an integer linear program, which minimizes system-wide control costs by finding the optimal distribution of NO x controls across the modeled boilers under an emission constraint. The result is a single optimized MACC that accounts for detailed, boiler-specific information related to NO x retrofits. Because the resultant MACCs do not take into account regional differences in air-quality standards or pre-existing NO x controls, the results should not be interpreted as a policy prescription. The general method as well as NO x -specific results presented here should be of significant value to modelers and policy analysts who must estimate the costs of pollution reduction.

Utility-preserving anonymization for health data publishing.

Science.gov (United States)

Lee, Hyukki; Kim, Soohyung; Kim, Jong Wook; Chung, Yon Dohn

2017-07-11

Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information. A common practice for the privacy-preserving data publishing is to anonymize the data before publishing, and thus satisfy privacy models such as k-anonymity. Among various anonymization techniques, generalization is the most commonly used in medical/health data processing. Generalization inevitably causes information loss, and thus, various methods have been proposed to reduce information loss. However, existing generalization-based data anonymization methods cannot avoid excessive information loss and preserve data utility. We propose a utility-preserving anonymization for privacy preserving data publishing (PPDP). To preserve data utility, the proposed method comprises three parts: (1) utility-preserving model, (2) counterfeit record insertion, (3) catalog of the counterfeit records. We also propose an anonymization algorithm using the proposed method. Our anonymization algorithm applies full-domain generalization algorithm. We evaluate our method in comparison with existence method on two aspects, information loss measured through various quality metrics and error rate of analysis result. With all different types of quality metrics, our proposed method show the lower information loss than the existing method. In the real-world EHRs analysis, analysis results show small portion of error between the anonymized data through the proposed method and original data. We propose a new utility-preserving anonymization method and an anonymization algorithm using the proposed method. Through experiments on various datasets, we show that the utility of EHRs anonymized by the proposed method is significantly better than those anonymized by previous approaches.

An operationally simple method for separating the rare-earth elements neodymium and dysprosium

Energy Technology Data Exchange (ETDEWEB)

Bogart, Justin A.; Lippincott, Connor A.; Carroll, Patrick J.; Schelter, Eric J. [Department of Chemistry, University of Pennsylvania, Philadelphia, PA (United States)

2015-07-06

Rare-earth metals are critical components of electronic materials and permanent magnets. Recycling of consumer materials is a promising new source of rare earths. To incentivize recycling there is a clear need for simple methods for targeted separations of mixtures of rare-earth metal salts. Metal complexes of a tripodal nitroxide ligand [{(2-"tBuNO)C_6H_4CH_2}{sub 3}N]{sup 3-} (TriNOx{sup 3-}), feature a size-sensitive aperture formed of its three η{sup 2}-(N,O) ligand arms. Exposure of metal cations in the aperture induces a self-associative equilibrium comprising [M(TriNOx)thf]/[M(TriNOx)]{sub 2} (M=rare-earth metal). Differences in the equilibrium constants (K{sub eq}) for early and late metals enables simple Nd/Dy separations through leaching with a separation ratio S{sub Nd/Dy}=359. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

New method of determining the thermal utilization factor of a cell; Nouvelle methode de determination du facteur d'utilisation thermique d'une cellule

Energy Technology Data Exchange (ETDEWEB)

Amouyal, A; Benoist, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1956-07-01

A new formula for the thermal utilization factor is derived, which, while comparable in simplicity to the formula given by elementary diffusion theory, furnishes much more precise results. This is clearly brought out by comparison with the results given by the S{sub n} and spherical harmonics methods. (author) [French] Une nouvelle expression du facteur d'utilisation thermique, d'une simplicite comparable a celle de Ia theorie elementaire, est etablie. La comparaison avec les resultats fournis par la methode S{sub n} et les methodes d'harmoniques spheriques montre que la precision obtenue par cette formule est tres superieure a celle que donne la theorie elementaire. (auteur)

Preliminary assessment of a method utilizing carbon dioxide and steelmaking slags to produce precipitated calcium carbonate

International Nuclear Information System (INIS)

Eloneva, Sanni; Said, Arshe; Fogelholm, Carl-Johan; Zevenhoven, Ron

2012-01-01

Highlights: ► An NH 4 -salt-based method utilizes CO 2 and steelmaking slags to produce pure CaCO 3 . ► It was determined if its economic potential warrants moving forward. ► Despite small solvent losses, the method was found to have economical potential. ► The method has significant CO 2 emissions reduction potential. ► Scaling up the reactor will allow for a more detailed design for the process. -- Abstract: One of the options that can contribute to the reduction of carbon dioxide emissions for climate change mitigation is the so-called CO 2 sequestration by mineral carbonation, or CO 2 mineral sequestration. Steel manufacturing could benefit from this option by utilizing its own by-products, i.e. steelmaking slags to combine with CO 2 . We have recently studied a method, where aqueous solution of ammonium salt (e.g. ammonium acetate, ammonium nitrate and ammonium chloride) is used to extract calcium selectively from the steel converter slag, followed by precipitation of pure calcium carbonate by bubbling CO 2 through the produced solution. The ammonium salt solution is recovered and re-used. The purpose of this research was to determine if the economic potential of the method warrants moving forward to large-scale application. Despite the small solvent losses, the method was found to have economical potential. In addition, it has significant CO 2 emission reduction potential as well. Scaling up the reactor from the small laboratory scale will allow more detailed design for the process to be made followed by a full economical evaluation including all of the important operational and capital investment costs.

Molecular characterization of autochthonous hydrocarbon utilizing ...

African Journals Online (AJOL)

Prof. Ogunji

Materials and Methods ... culturable hydrocarbon utilizing bacteria (HUB) were enumerated by vapour phase ... hydrocarbon utilizing bacterial isolates by boiling method according to ... obtained in this investigation are consistent with past field studies (Kostka et ... Microbial and other related changes in a Niger sediment.

An Experiential-Based Learning Method Aiming to Improve Spatial Awareness Utilizing GPS, Geocaching, and Geo-Selfies

Science.gov (United States)

Flynn, K. Colton; Popp, Jennie

2016-01-01

Many educators have suggested that spatial awareness is vital in the foundation of geography curricula, as well as the ability to utilize geospatial technologies (National Research Council 2006; Kerski 2008; Lee and Bednarz 2009; Favier and Van der Schee 2014). The purpose of this research was to identify a low-cost and effective method to improve…

NESTLE: Few-group neutron diffusion equation solver utilizing the nodal expansion method for eigenvalue, adjoint, fixed-source steady-state and transient problems

International Nuclear Information System (INIS)

Turinsky, P.J.; Al-Chalabi, R.M.K.; Engrand, P.; Sarsour, H.N.; Faure, F.X.; Guo, W.

1994-06-01

NESTLE is a FORTRAN77 code that solves the few-group neutron diffusion equation utilizing the Nodal Expansion Method (NEM). NESTLE can solve the eigenvalue (criticality); eigenvalue adjoint; external fixed-source steady-state; or external fixed-source. or eigenvalue initiated transient problems. The code name NESTLE originates from the multi-problem solution capability, abbreviating Nodal Eigenvalue, Steady-state, Transient, Le core Evaluator. The eigenvalue problem allows criticality searches to be completed, and the external fixed-source steady-state problem can search to achieve a specified power level. Transient problems model delayed neutrons via precursor groups. Several core properties can be input as time dependent. Two or four energy groups can be utilized, with all energy groups being thermal groups (i.e. upscatter exits) if desired. Core geometries modelled include Cartesian and Hexagonal. Three, two and one dimensional models can be utilized with various symmetries. The non-linear iterative strategy associated with the NEM method is employed. An advantage of the non-linear iterative strategy is that NSTLE can be utilized to solve either the nodal or Finite Difference Method representation of the few-group neutron diffusion equation

Studies of short-lived radicals in the. gamma. -irradiated aqueous solution of uridine-5'-monophosphate by the spin-trapping method and the liquid chromatography

Energy Technology Data Exchange (ETDEWEB)

Kominami, S [Hiroshima Univ. (Japan); Rokushika, S; Hatano, H

1976-12-01

An aerated aqueous solution of uridine-5'-monophosphate was ..gamma..-irradiated with 2-methyl-2-nitrosopropane as a spin-trapping reagent. Liquid chromatography was applied to separate the stable nitroxide radicals in the irradiated solution. The radicals were detected by U.V. and e.s.r. spectrometry. The e.s.r. detection showed four peaks in the chromatogram. The orcinol method for detection of the residual sugar moieties was applied before and after reduction of the base to determine the existence of the 5,6-double bond for the molecules in each fraction. From the combined results of the e.s.r. and orcinol methods, the short-lived radicals which were trapped by 2-methyl-2-nitrosopropane were identified as radicals of N-1 and C-6 positions of the base moiety and t-butyl radicals which was the radiolytic product of the trapping reagent.

Systematic methods and tools for design of sustainable chemical processes for CO2 utilization

DEFF Research Database (Denmark)

Kongpanna, Pichayapan; Babi, Deenesh K.; Pavarajarn, Varong

2016-01-01

A systematic computer-aided framework for sustainable process design is presented together with its application to the synthesis and generation of processing networks for dimethyl carbonate (DMC) production with CO2 utilization. The framework integrated with various methods, tools, algorithms......-stage involves selection and analysis of the identified networks as a base case design in terms of operational feasibility, economics, life cycle assessment factors and sustainability measures, which are employed to establish targets for improvement in the next-stage. The innovation-stage involves generation...

Using qualitative methods to inform the trade-off between content validity and consistency in utility assessment: the example of type 2 diabetes and Alzheimer's Disease

Directory of Open Access Journals (Sweden)

Gargon Elizabeth

2010-02-01

Full Text Available Abstract Background Key stakeholders regard generic utility instruments as suitable tools to inform health technology assessment decision-making regarding allocation of resources across competing interventions. These instruments require a 'descriptor', a 'valuation' and a 'perspective' of the economic evaluation. There are various approaches that can be taken for each of these, offering a potential lack of consistency between instruments (a basic requirement for comparisons across diseases. The 'reference method' has been proposed as a way to address the limitations of the Quality-Adjusted Life Year (QALY. However, the degree to which generic measures can assess patients' specific experiences with their disease would remain unresolved. This has been neglected in the discussions on methods development and its impact on the QALY values obtained and resulting cost per QALY estimate underestimated. This study explored the content of utility instruments relevant to type 2 diabetes and Alzheimer's disease (AD as examples, and the role of qualitative research in informing the trade-off between content coverage and consistency. Method A literature review was performed to identify qualitative and quantitative studies regarding patients' experiences with type 2 diabetes or AD, and associated treatments. Conceptual models for each indication were developed. Generic- and disease-specific instruments were mapped to the conceptual models. Results Findings showed that published descriptions of relevant concepts important to patients with type 2 diabetes or AD are available for consideration in deciding on the most comprehensive approach to utility assessment. While the 15-dimensional health related quality of life measure (15D seemed the most comprehensive measure for both diseases, the Health Utilities Index 3 (HUI 3 seemed to have the least coverage for type 2 diabetes and the EuroQol-5 Dimensions (EQ-5D for AD. Furthermore, some of the utility instruments

Utilizing Computational Probabilistic Methods to Derive Shock Specifications in a Nondeterministic Environment

Energy Technology Data Exchange (ETDEWEB)

FIELD JR.,RICHARD V.; RED-HORSE,JOHN R.; PAEZ,THOMAS L.

2000-10-25

One of the key elements of the Stochastic Finite Element Method, namely the polynomial chaos expansion, has been utilized in a nonlinear shock and vibration application. As a result, the computed response was expressed as a random process, which is an approximation to the true solution process, and can be thought of as a generalization to solutions given as statistics only. This approximation to the response process was then used to derive an analytically-based design specification for component shock response that guarantees a balanced level of marginal reliability. Hence, this analytically-based reference SRS might lead to an improvement over the somewhat ad hoc test-based reference in the sense that it will not exhibit regions of conservativeness. nor lead to overtesting of the design.

Utility Maximization in Nonconvex Wireless Systems

CERN Document Server

Brehmer, Johannes

2012-01-01

This monograph formulates a framework for modeling and solving utility maximization problems in nonconvex wireless systems. First, a model for utility optimization in wireless systems is defined. The model is general enough to encompass a wide array of system configurations and performance objectives. Based on the general model, a set of methods for solving utility maximization problems is developed. The development is based on a careful examination of the properties that are required for the application of each method. The focus is on problems whose initial formulation does not allow for a solution by standard convex methods. Solution approaches that take into account the nonconvexities inherent to wireless systems are discussed in detail. The monograph concludes with two case studies that demonstrate the application of the proposed framework to utility maximization in multi-antenna broadcast channels.

A Method of Maximum Power Control in Single-phase Utility Interactive Photovoltaic Generation System by using PWM Current Source Inverter

Science.gov (United States)

Neba, Yasuhiko

This paper deals with a maximum power point tracking (MPPT) control of the photovoltaic generation with the single-phase utility interactive inverter. The photovoltaic arrays are connected by employing the PWM current source inverter to the utility. The use of the pulsating dc current and voltage allows the maximum power point to be searched. The inverter can regulate the array voltage and keep the arrays to the maximum power. This paper gives the control method and the experimental results.

The effect of the rate and method of nitrogen application on nitrogen uptake and utilization by broccoli (Brassica oleracea var. italica)

NARCIS (Netherlands)

Everaarts, A.P.; Willigen, de P.

1999-01-01

The effect of the rate and method of nitrogen application on nitrogen uptake and utilization by broccoli (Brassica oleracea var. italica) was studied in four field experiments. The methods of application were broadcast application vs band placement and split application. Maximum uptake of nitrogen

Differences in health insurance and health service utilization among Asian Americans: method for using the NHIS to identify unique patterns between ethnic groups.

Science.gov (United States)

Ruy, Hosihn; Young, Wendy B; Kwak, Hoil

2002-01-01

The purpose of this study is to outline a method to identify the characteristics of socioeconomic variables in determining the differences in health insurance coverage and health services utilization patterns for different ethnic groups, using the behavioural model of health service utilization. A sample drawn from Asian American adult respondents to the 1992, 1993, and 1994 National Health Interview Surveys (NHIS) in the USA formed the data set. The results showed Asian Americans as not being homogeneous. There were distinctly different demographic and socioeconomic characteristics between six Asian American ethnic groups that affect health insurance coverage and health service utilization. The study method is useful for constructing health policy and services to address the general public need without adversely affecting smaller minority groups. Secondary analysis of well-constructed national data sets such as the specific Asian ethnic groups in NHIS, offers a rich method for predicting the differential impact of specific health policies on various ethnic groups.

Prediction method of unburnt carbon for coal fired utility boiler using image processing technique of combustion flame

International Nuclear Information System (INIS)

Shimoda, M.; Sugano, A.; Kimura, T.; Watanabe, Y.; Ishiyama, K.

1990-01-01

This paper reports on a method predicting unburnt carbon in a coal fired utility boiler developed using an image processing technique. The method consists of an image processing unit and a furnace model unit. temperature distribution of combustion flames can be obtained through the former unit. The later calculates dynamics of the carbon reduction from the burner stages to the furnace outlet using coal feed rate, air flow rate, chemical and ash content of coal. An experimental study shows that the prediction error of the unburnt carbon can be reduced to 10%

The pyrolytic-plasma method and the device for the utilization of hazardous waste containing organic compounds

Energy Technology Data Exchange (ETDEWEB)

Opalińska, Teresa [Tele and Radio Research Institute, Ratuszowa 11, 03-450 Warsaw (Poland); Wnęk, Bartłomiej, E-mail: bartlomiej.wnek@itr.org.pl [Tele and Radio Research Institute, Ratuszowa 11, 03-450 Warsaw (Poland); Witowski, Artur; Juszczuk, Rafał; Majdak, Małgorzata [Tele and Radio Research Institute, Ratuszowa 11, 03-450 Warsaw (Poland); Bartusek, Stanilav [VŠB—Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava − Poruba Czech Republic (Czech Republic)

2016-11-15

Highlights: • A first stage of the process of waste utilization consisted in pyrolysis of waste. • Then the pyrolytic gas was oxidized with a use of non-equilibrium plasma. • The device for the process implementation was built and characterized. • Correctness of the device operation was proven with a use of the decomposition of PE. • Usefulness of the method was proven in the process of utilization of EW. - Abstract: This paper is focused on the new method of waste processing. The waste, including hazardous waste, contain organic compounds. The method consists in two main processes: the pyrolysis of waste and the oxidation of the pyrolytic gas with a use of non-equilibrium plasma. The practical implementation of the method requires the design, construction and testing of the new device in large laboratory scale. The experiments were carried out for the two kinds of waste: polyethylene as a model waste and the electronic waste as a real waste. The process of polyethylene decomposition showed that the operation of the device is correct because 99.74% of carbon moles contained in the PE samples was detected in the gas after the process. Thus, the PE samples practically were pyrolyzed completely to hydrocarbons, which were completely oxidized in the plasma reactor. It turned out that the device is useful for decomposition of the electronic waste. The conditions in the plasma reactor during the oxidation process of the pyrolysis products did not promote the formation of PCDD/Fs despite the presence of the oxidizing conditions. An important parameter determining the efficiency of the oxidation of the pyrolysis products is gas temperature in the plasma reactor.

Cross-border shipment route selection utilizing analytic hierarchy process (AHP method

Directory of Open Access Journals (Sweden)

Veeris Ammarapala

2018-02-01

Full Text Available Becoming a member of ASEAN Economic Community (AEC, Thailand expects a growth of cross-border trade with neighboring countries, especially the agricultural products shipment. To facilitate this, a number of strategies are set, such as the utilization of single check point, the Asian Highway (AH route development, and the truck lane initiation. However, majority of agricultural products traded through the borders are transported using the rural roads, from growing area to the factory, before continuing to the borders using different highways. It is, therefore, necessary for the Department of Rural Roads (DRR to plan for rural road improvement to accommodate the growth of the cross-border trades in the near future. This research, thus, aims to select potential rural roads to support cross-border shipment utilizing the analytic hierarchy process (AHP method. Seven key factors affecting rural roads selection, with references from transport and other related literatures, are extracted. They include:1 cross-border trade value, 2 distance from border to rural road, 3 agriculture and processed agriculture goods transported across the border, 4 compatibility with national strategies, 5 area characteristics around the rural road, 6 truck volume, and 7 number of rural roads in the radius of 50 kilometers from the border. Interviews are conducted with the experts based on seven key factors to collect data for the AHP analysis. The results identify the weight of each factor with an acceptable consistency ratio. It shows that the cross-border trade value is the most important factor as it achieves the highest weight. The distance from border to rural road and the compatibility with national strategies are also found crucial when making rural road selection decision. The Department of Rural Roads could use the results to select suitable roads, and plan for road improvement to support the crossborder shipment when the AEC is fully implemented.

Utilization technology on slurried ash

Energy Technology Data Exchange (ETDEWEB)

Kanbe, Yoshio; Yasuda, Minoru; Furuki, Yasuhiko [The Coal Mining Research Centre, Japan, Tokyo, Japan; Electric Power Development Co., Ltd., Tokyo (Japan))

1987-08-01

Three research results of the utilization technology on slurried ash were reported. As for the utilization as the fly ash quick setting (FQS) backfill grout for tail void in shield works of tunneling, grout blending was simplified, the blended solution of cement, clay, additives and water was stabilized, and a favorable workability and long term durability were obtained. As for the utilization as the material of a SMW (soil mixing wall) method for continuous walls in long shaft digging, a fly ash-gypsum-cement (FGC) stabilizer showed an excellent workability and remarkably high water-tightness as compared with conventional cement bentonite. As for the utilization as the material of an injection method of overlay mats in foundation works of light weight structures on the sea bed mud foundation, since a FGC concrete weight in water was remarkably light as 0.7t/m{sup 3}, no both large mold form strength and vibration compacting were required. 10 figs., 8 tabs.

Utilization of a liquid crystal spatial light modulator in a gray scale detour phase method for Fourier holograms.

Science.gov (United States)

Makey, Ghaith; El-Daher, Moustafa Sayem; Al-Shufi, Kanj

2012-11-10

This paper introduces a new modification for the well-known binary detour phase method, which is largely used to represent Fourier holograms; the modification utilizes gray scale level control provided by a liquid crystal spatial light modulator to improve the traditional binary detour phase. Results are shown by both simulation and experiment.

Comparing the Medicaid Retrospective Drug Utilization Review Program Cost-Savings Methods Used by State Agencies.

Science.gov (United States)

Prada, Sergio I

2017-12-01

The Medicaid Drug Utilization Review (DUR) program is a 2-phase process conducted by Medicaid state agencies. The first phase is a prospective DUR and involves electronically monitoring prescription drug claims to identify prescription-related problems, such as therapeutic duplication, contraindications, incorrect dosage, or duration of treatment. The second phase is a retrospective DUR and involves ongoing and periodic examinations of claims data to identify patterns of fraud, abuse, underutilization, drug-drug interaction, or medically unnecessary care, implementing corrective actions when needed. The Centers for Medicare & Medicaid Services requires each state to measure prescription drug cost-savings generated from its DUR programs on an annual basis, but it provides no guidance or unified methodology for doing so. To describe and synthesize the methodologies used by states to measure cost-savings using their Medicaid retrospective DUR program in federal fiscal years 2014 and 2015. For each state, the cost-savings methodologies included in the Medicaid DUR 2014 and 2015 reports were downloaded from Medicaid's website. The reports were then reviewed and synthesized. Methods described by the states were classified according to research designs often described in evaluation textbooks. In 2014, the most often used prescription drugs cost-savings estimation methodology for the Medicaid retrospective DUR program was a simple pre-post intervention method, without a comparison group (ie, 12 states). In 2015, the most common methodology used was a pre-post intervention method, with a comparison group (ie, 14 states). Comparisons of savings attributed to the program among states are still unreliable, because of a lack of a common methodology available for measuring cost-savings. There is great variation among states in the methods used to measure prescription drug utilization cost-savings. This analysis suggests that there is still room for improvement in terms of

Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models.

Science.gov (United States)

Bobko, Andrey A; Evans, Jason; Denko, Nicholas C; Khramtsov, Valery V

2017-06-01

Tissue oxygenation, extracellular acidity, and tissue reducing capacity are among crucial parameters of tumor microenvironment (TME) of significant importance for tumor pathophysiology. In this paper, we demonstrate the complementary application of particulate lithium octa-n-butoxy-naphthalocyanine and soluble nitroxide paramagnetic probes for monitoring of these TME parameters using electron paramagnetic resonance (EPR) technique. Two different types of therapeutic interventions were studied: hypothermia and systemic administration of metabolically active drug. In summary, the results demonstrate the utility of EPR technique for non-invasive concurrent longitudinal monitoring of physiologically relevant chemical parameters of TME in mouse xenograft tumor models, including that under therapeutic intervention.

Deriving the expected utility of a predictive model when the utilities are uncertain.

Science.gov (United States)

Cooper, Gregory F; Visweswaran, Shyam

2005-01-01

Predictive models are often constructed from clinical databases with the goal of eventually helping make better clinical decisions. Evaluating models using decision theory is therefore natural. When constructing a model using statistical and machine learning methods, however, we are often uncertain about precisely how the model will be used. Thus, decision-independent measures of classification performance, such as the area under an ROC curve, are popular. As a complementary method of evaluation, we investigate techniques for deriving the expected utility of a model under uncertainty about the model's utilities. We demonstrate an example of the application of this approach to the evaluation of two models that diagnose coronary artery disease.

Nitroxydes chiraux à squelette imidazolidin-4-one comme catalyseurs d'oxydation énantiosélective d'alcools par O2

OpenAIRE

Carbo Lopez , Marta

2014-01-01

The aim of this thesis was to evaluate the use of chiral nitroxides containing an imidazolidin-4-one squeletton as enantioselective catalysts for the aerobic oxidation of alcohols. In this view, several nitroxides with different α substituents have been synthesized to investigate the influence of these groups. Several co-catalysts reported in the literature have been tested for the oxidation reactions that take place at room temperature and atmospheric pressure. These catalytic systems can be...

Density meters utilizing ionizing radiation: definitions and test methods

International Nuclear Information System (INIS)

Anon.

1981-01-01

This standard is applicable to density meters utilizing ionizing radiation, designed for the measurement of the density of liquids, slurries or fluidized solids. The standard applies to transmission-type instruments only. Reference to compliance with this standard shall identify any deviations and the reasons for such deviations. Safety aspects are not included but should fulfill the requirements of all relevant internationally accepted standards

Empirical Specification of Utility Functions.

Science.gov (United States)

Mellenbergh, Gideon J.

Decision theory can be applied to four types of decision situations in education and psychology: (1) selection; (2) placement; (3) classification; and (4) mastery. For the application of the theory, a utility function must be specified. Usually the utility function is chosen on a priori grounds. In this paper methods for the empirical assessment…

Development of a new free radical absorption capacity assay method for antioxidants: aroxyl radical absorption capacity (ARAC).

Science.gov (United States)

Nagaoka, Shin-ichi; Nagai, Kanae; Fujii, Yuko; Ouchi, Aya; Mukai, Kazuo

2013-10-23

A new free radical absorption capacity assay method is proposed with use of an aroxyl radical (2,6-di-tert-butyl-4-(4'-methoxyphenyl)phenoxyl radical) and stopped-flow spectroscopy and is named the aroxyl radical absorption capacity (ARAC) assay method. The free radical absorption capacity (ARAC value) of each tocopherol was determined through measurement of the radical-scavenging rate constant in ethanol. The ARAC value could also be evaluated through measurement of the half-life of the aroxyl radical during the scavenging reaction. For the estimation of the free radical absorption capacity, the aroxyl radical was more suitable than the DPPH radical, galvinoxyl, and p-nitrophenyl nitronyl nitroxide. The ARAC value in tocopherols showed the same tendency as the free radical absorption capacities reported previously, and the tendency was independent of an oxygen radical participating in the scavenging reaction and of a medium surrounding the tocopherol and oxygen radical. The ARAC value can be directly connected to the free radical-scavenging rate constant, and the ARAC method has the advantage of treating a stable and isolable radical (aroxyl radical) in a user-friendly organic solvent (ethanol). The ARAC method was also successfully applied to a palm oil extract. Accordingly, the ARAC method would be useful in free radical absorption capacity assay of antioxidative reagents and foods.

Measurement of rotational dynamics by the simultaneous nonlinear analysis of optical and EPR data.

OpenAIRE

Hustedt, E J; Cobb, C E; Beth, A H; Beechem, J M

1993-01-01

In the preceding companion article in this issue, an optical dye and a nitroxide radical were combined in a new dual function probe, 5-SLE. In this report, it is demonstrated that time-resolved optical anisotropy and electron paramagnetic resonance (EPR) data can be combined in a single analysis to measure rotational dynamics. Rigid-limit and rotational diffusion models for simulating nitroxide EPR data have been incorporated into a general non-linear least-squares procedure based on the Marq...

Modulating effect of new potential antimelanomic agents, spin-labeled triazenes and nitrosoureas on the DOPA-oxidase activity of tyrosinase.

Science.gov (United States)

Gadjeva, V; Zheleva, A; Raikova, E

1999-07-01

The modulating effect of newly synthesized alkylating spin labeled triazene and spin labeled nitrosourea derivatives on the DOPA-oxidase activity of mushroom tyrosinase has been investigated by Bumett's spectrophotometric method (Burnett et al., 1967). All spin labeled triazenes have exhibited activating effect on DOPA-oxidase activity of tyrosinase, whereas clinically used triazene (DTIC), which does not contain nitroxide moiety, have showed inhibiting effect. At the same experimental conditions the spin labeled aminoacid nitrosoureas have showed dual effect - activating, in the beginning of the enzyme reaction and inhibiting later on. It is deduced that the activating effect of the spin labeled compounds is due to the nitroxide moiety and the inhibiting effect of all compounds depends on their half-life time. This study might contribute to make more clear the mechanism of action of the new compounds and on the other hand would come in quite useful as a preliminary prognosis for their antimelanomic activity.

Thermal Unit Commitment Scheduling Problem in Utility System by Tabu Search Embedded Genetic Algorithm Method

Directory of Open Access Journals (Sweden)

C. Christober Asir Rajan

2008-06-01

Full Text Available The objective of this paper is to find the generation scheduling such that the total operating cost can be minimized, when subjected to a variety of constraints. This also means that it is desirable to find the optimal unit commitment in the power system for the next H hours. A 66-bus utility power system in India demonstrates the effectiveness of the proposed approach; extensive studies have also been performed for different IEEE test systems consist of 24, 57 and 175 buses. Numerical results are shown comparing the cost solutions and computation time obtained by different intelligence and conventional methods.

Diagnostic utility of the cell block method versus the conventional smear study in pleural fluid cytology.

Science.gov (United States)

Shivakumarswamy, Udasimath; Arakeri, Surekha U; Karigowdar, Mahesh H; Yelikar, Br

2012-01-01

The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered as a definitive diagnosis. It helps in staging, prognosis and management of the patients in malignancies and also gives information about various inflammatory and non-inflammatory lesions. Diagnostic problems arise in everyday practice to differentiate reactive atypical mesothelial cells and malignant cells by the routine conventional smear (CS) method. To compare the morphological features of the CS method with those of the cell block (CB) method and also to assess the utility and sensitivity of the CB method in the cytodiagnosis of pleural effusions. The study was conducted in the cytology section of the Department of Pathology. Sixty pleural fluid samples were subjected to diagnostic evaluation for over a period of 20 months. Along with the conventional smears, cell blocks were prepared by using 10% alcohol-formalin as a fixative agent. Statistical analysis with the 'z test' was performed to identify the cellularity, using the CS and CB methods. Mc. Naemer's χ(2)test was used to identify the additional yield for malignancy by the CB method. Cellularity and additional yield for malignancy was 15% more by the CB method. The CB method provides high cellularity, better architectural patterns, morphological features and an additional yield of malignant cells, and thereby, increases the sensitivity of the cytodiagnosis when compared with the CS method.

Solar energy storage and utilization

Science.gov (United States)

Yuan, S. W.; Bloom, A. M.

1976-01-01

A method of storing solar energy in the ground for heating residential buildings is described. The method would utilize heat exchanger pipes with a circulating fluid to transfer the energy beneath the surface as well as to extract the stored energy.

Flash memory management system and method utilizing multiple block list windows

Science.gov (United States)

Chow, James (Inventor); Gender, Thomas K. (Inventor)

2005-01-01

The present invention provides a flash memory management system and method with increased performance. The flash memory management system provides the ability to efficiently manage and allocate flash memory use in a way that improves reliability and longevity, while maintaining good performance levels. The flash memory management system includes a free block mechanism, a disk maintenance mechanism, and a bad block detection mechanism. The free block mechanism provides efficient sorting of free blocks to facilitate selecting low use blocks for writing. The disk maintenance mechanism provides for the ability to efficiently clean flash memory blocks during processor idle times. The bad block detection mechanism provides the ability to better detect when a block of flash memory is likely to go bad. The flash status mechanism stores information in fast access memory that describes the content and status of the data in the flash disk. The new bank detection mechanism provides the ability to automatically detect when new banks of flash memory are added to the system. Together, these mechanisms provide a flash memory management system that can improve the operational efficiency of systems that utilize flash memory.

The Value of Sustainable Knowledge Transfer Methods for SMEs, Utilizing Socio-Technical Networks and Complex Systems

Directory of Open Access Journals (Sweden)

Susu Nousala

2010-12-01

Full Text Available This paper will examine the development of sustainable SME methods for tracking tacit (informal knowledge transfer as a series of networks of larger complex system. Understanding sustainable systems begins with valuing tacit knowledge networks and their ability to produce connections on multiple levels. The behaviour of the social or socio aspects of a system in relation to the explicit formal/physical structures need to be understood and actively considered when utilizing methodologies for interacting within complex systems structures. This paper utilizes theory from several previous studies to underpin the key case study discussed. This approach involved examining the behavioural phenomena of an SME knowledge network. The knowledge network elements were highlighted to identify their value within an SME structure. To understand the value of these emergent elements from between tacit and explicit knowledge networks, is to actively, simultaneously and continuous support sustainable development for SME organizations. The simultaneous links within and between groups of organizations is crucial for understanding sustainable networking structures of complex systems.

Diagnostic utility of the cell block method versus the conventional smear study in pleural fluid cytology

Directory of Open Access Journals (Sweden)

Udasimath Shivakumarswamy

2012-01-01

Full Text Available Background: The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered as a definitive diagnosis. It helps in staging, prognosis and management of the patients in malignancies and also gives information about various inflammatory and non-inflammatory lesions. Diagnostic problems arise in everyday practice to differentiate reactive atypical mesothelial cells and malignant cells by the routine conventional smear (CS method. Aims: To compare the morphological features of the CS method with those of the cell block (CB method and also to assess the utility and sensitivity of the CB method in the cytodiagnosis of pleural effusions. Materials and Methods: The study was conducted in the cytology section of the Department of Pathology. Sixty pleural fluid samples were subjected to diagnostic evaluation for over a period of 20 months. Along with the conventional smears, cell blocks were prepared by using 10% alcohol-formalin as a fixative agent. Statistical analysis with the ′z test′ was performed to identify the cellularity, using the CS and CB methods. Mc. Naemer′s χ2 test was used to identify the additional yield for malignancy by the CB method. Results: Cellularity and additional yield for malignancy was 15% more by the CB method. Conclusions: The CB method provides high cellularity, better architectural patterns, morphological features and an additional yield of malignant cells, and thereby, increases the sensitivity of the cytodiagnosis when compared with the CS method.

Few-layer graphene growth from polystyrene as solid carbon source utilizing simple APCVD method

Science.gov (United States)

Ahmadi, Shahrokh; Afzalzadeh, Reza

2016-07-01

This research article presents development of an economical, simple, immune and environment friendly process to grow few-layer graphene by controlling evaporation rate of polystyrene on copper foil as catalyst and substrate utilizing atmospheric pressure chemical vapor deposition (APCVD) method. Evaporation rate of polystyrene depends on molecular structure, amount of used material and temperature. We have found controlling rate of evaporation of polystyrene by controlling the source temperature is easier than controlling the material weight. Atomic force microscopy (AFM) as well as Raman Spectroscopy has been used for characterization of the layers. The frequency of G‧ to G band ratio intensity in some samples varied between 0.8 and 1.6 corresponding to few-layer graphene. Topography characterization by atomic force microscopy confirmed Raman results.

"Utilizing" signal detection theory.

Science.gov (United States)

Lynn, Spencer K; Barrett, Lisa Feldman

2014-09-01

What do inferring what a person is thinking or feeling, judging a defendant's guilt, and navigating a dimly lit room have in common? They involve perceptual uncertainty (e.g., a scowling face might indicate anger or concentration, for which different responses are appropriate) and behavioral risk (e.g., a cost to making the wrong response). Signal detection theory describes these types of decisions. In this tutorial, we show how incorporating the economic concept of utility allows signal detection theory to serve as a model of optimal decision making, going beyond its common use as an analytic method. This utility approach to signal detection theory clarifies otherwise enigmatic influences of perceptual uncertainty on measures of decision-making performance (accuracy and optimality) and on behavior (an inverse relationship between bias magnitude and sensitivity optimizes utility). A "utilized" signal detection theory offers the possibility of expanding the phenomena that can be understood within a decision-making framework. © The Author(s) 2014.

A LINEAR PROGRAMMING METHOD TO ENHANCE RESOURCE UTILIZATION CASE OF ETHIOPIAN APPAREL SECTOR

Directory of Open Access Journals (Sweden)

Gezahegn Tesfaye

2016-06-01

Full Text Available The Ethiopian industrial development strategy is characterized by export-led and labor intensive industrialization. The country is emerging as the most important investment destination in its apparel sector. Thought this sector is expected to generate more income from the export market, its export earnings remain trivial mainly due to the inefficient organizational resource utilization. One of the competent techniques that help companies to efficiently improve the use of their resources to increase their profit is linear programming. In apparel manufacturing firms, efficient use of materials such as fabrics and sewing threads and processing time at different stages of production as well as minimization of labor and materials cost are necessary to enhance their profitability. Cutting, sewing, and finishing operations deserve more attention for apparel process optimization. However, the issue of proper resource allocation remains an unsolved problem within the Ethiopian apparel industry. The aim of this research is to devise efficient resource utilization mechanism for Ethiopian apparel sector to improve their resource utilization and profitability, taking one of the garment factories engaged in the export market as a case study. Five types of products the company is currently producing, the amount of resources employed to produce each unit of the products, and the value of profit per unit from the sale of each products have been collected from the case company. The monthly availability of resources utilized and the monthly production volume of the five products have also been collected from the company. The data gathered was mathematically modeled using a linear programming technique, and solved using MS-Excel solver. The findings of the study depicts that all of the organizational resources are severely underutilized. This research proved that the resource utilization of the case company can be improved from 46.41% of the current resource

Factors associated with the utilization of primary care emergency centers in a Spanish region with high population dispersion: a mixed-methods study.

Science.gov (United States)

Sanz-Barbero, Belén; Otero-García, Laura; Blasco-Hernández, Teresa; San Sebastián, Miguel

2014-09-03

Adequate access to primary care emergency centers is particularly important in rural areas isolated from urban centers. However, variability in utilization of emergency services located in primary care centers among inhabitants of nearby geographical areas is understudied. The objectives of this study are twofold: 1) to analyze the association between the availability of municipal emergency care centers and utilization of primary care emergency centers (PCEC), in a Spanish region with high population dispersion; and 2) to determine healthcare providers' perceptions regarding PCEC utilization. A mixed-methods study was conducted. Quantitative phase: multilevel logistic regression modeling using merged data from the 2003 Regional Health Survey of Castile and Leon and the 2001 census data (Spain). Qualitative phase:14 in-depth- interviews of rural-based PCEC providers. Having PCEC as the only emergency center in the municipality was directly associated with its utilization (p use. PCEC users were considered to be predominantly workers and students with scheduling conflicts with rural primary care opening hours. The location of emergency care centers is associated with PCEC utilization. Increasing access to primary care by extending hours may be an important step toward optimal PCEC utilization. Further research would determine whether lower PCEC use by certain groups is associated with disparities in access to care.

Sequestration and utilization of carbon dioxide by chemical and biological methods for biofuels and biomaterials by chemoautotrophs: Opportunities and challenges.

Science.gov (United States)

Thakur, Indu Shekhar; Kumar, Manish; Varjani, Sunita J; Wu, Yonghong; Gnansounou, Edgard; Ravindran, Sindhu

2018-05-01

To meet the CO 2 emission reduction targets, carbon dioxide capture and utilization (CCU) comes as an evolve technology. CCU concept is turning into a feedstock and technologies have been developed for transformation of CO 2 into useful organic products. At industrial scale, utilization of CO 2 as raw material is not much significant as compare to its abundance. Mechanisms in nature have evolved for carbon concentration, fixation and utilization. Assimilation and subsequent conversion of CO 2 into complex molecules are performed by the photosynthetic and chemolithotrophic organisms. In the last three decades, substantial research is carry out to discover chemical and biological conversion of CO 2 in various synthetic and biological materials, such as carboxylic acids, esters, lactones, polymer biodiesel, bio-plastics, bio-alcohols, exopolysaccharides. This review presents an over view of catalytic transformation of CO 2 into biofuels and biomaterials by chemical and biological methods. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Systematic Review and Meta-analysis of Childhood Health Utilities.

Science.gov (United States)

Kwon, Joseph; Kim, Sung Wook; Ungar, Wendy J; Tsiplova, Kate; Madan, Jason; Petrou, Stavros

2018-04-01

A common feature of most reviews or catalogues of health utilities has been their focus on adult health states or derivation of values from adult populations. More generally, utility measurement in or on behalf of children has been constrained by several methodological concerns. The objective of this study was to conduct the first comprehensive systematic review and meta-analysis of primary utility data for childhood conditions and descriptors, and to determine the effects of methodological factors on childhood utilities. The review followed PRISMA guidelines. PubMed, Embase, Web of Science, PsycINFO, EconLit, CINAHL and Cochrane Library were searched for primary studies reporting health utilities for childhood conditions or descriptors using direct or indirect valuation methods. The Paediatric Economic Database Evaluation (PEDE) Porject was also searched for cost-utility analyses with primary utility values. Mean or median utilities for each of the main samples were catalogued, and weighted averages of utilities for each health condition were estimated, by valuation method. Mixed-effects meta-regression using hierarchical linear modeling was conducted for the most common valuation methods to estimate the utility decrement for each health condition category relative to general childhood population health, as well as the independent effects of methodological factors. The literature searches resulted in 272 eligible studies. These yielded 3,414 utilities when all sub-groups were considered, covering all ICD-10 chapters relevant to childhood health, 19 valuation methods, 12 respondent types, 8 modes of administration, and data from 36 countries. A total of 1,191 utility values were obtained when only main study samples were considered, and these were catalogued by health condition or descriptor, and methodological characteristics. 1,073 mean utilities for main samples were used for fixed-effects meta-analysis by health condition and valuation method. Mixed

Can macular xanthophylls replace cholesterol in formation of the liquid-ordered phase in lipid-bilayer membranes?

OpenAIRE

Subczynski, Witold K.; Wisniewska, Anna; Widomska, Justyna

2012-01-01

Lateral organization of membranes made from binary mixtures of dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) and macular xanthophylls (lutein or zeaxanthin) was investigated using the saturation-recovery (SR) EPR spin-labeling discrimination by oxygen transport (DOT) method in which the bimolecular collision rate of molecular oxygen with the nitroxide spin label is measured. This work was undertaken to examine whether or not lutein and zeaxanthin, macular xant...

Expected utility without utility

OpenAIRE

Castagnoli, E.; Licalzi, M.

1996-01-01

This paper advances an interpretation of Von Neumann–Morgenstern’s expected utility model for preferences over lotteries which does not require the notion of a cardinal utility over prizes and can be phrased entirely in the language of probability. According to it, the expected utility of a lottery can be read as the probability that this lottery outperforms another given independent lottery. The implications of this interpretation for some topics and models in decision theory are considered....

Improving the utilization of research knowledge in agri-food public health: a mixed-method review of knowledge translation and transfer.

Science.gov (United States)

Rajić, Andrijana; Young, Ian; McEwen, Scott A

2013-05-01

Knowledge translation and transfer (KTT) aims to increase research utilization and ensure that the best available knowledge is used to inform policy and practice. Many frameworks, methods, and terms are used to describe KTT, and the field has largely developed in the health sector over the past decade. There is a need to review key KTT principles and methods in different sectors and evaluate their potential application in agri-food public health. We conducted a structured mixed-method review of the KTT literature. From 827 citations identified in a comprehensive search, we characterized 160 relevant review articles, case studies, and reports. A thematic analysis was conducted on a prioritized and representative subset of 33 articles to identify key principles and characteristics for ensuring effective KTT. The review steps were conducted by two or more independent reviewers using structured and pretested forms. We identified five key principles for effective KTT that were described within two contexts: to improve research utilization in general and to inform policy-making. To ensure general research uptake, there is a need for the following: (1) relevant and credible research; (2) ongoing interactions between researchers and end-users; (3) organizational support and culture; and (4) monitoring and evaluation. To inform policy-making, (5) researchers must also address the multiple and competing contextual factors of the policy-making process. We also describe 23 recommended and promising KTT methods, including six synthesis (e.g., systematic reviews, mixed-method reviews, and rapid reviews); nine dissemination (e.g., evidence summaries, social media, and policy briefs); and eight exchange methods (e.g., communities of practice, knowledge brokering, and policy dialogues). A brief description, contextual example, and key references are provided for each method. We recommend a wider endorsement of KTT principles and methods in agri-food public health, but there are

Treatment of Solar Generation in Electric Utility Resource Planning

Energy Technology Data Exchange (ETDEWEB)

Sterling, J.; McLaren, J.; Taylor, M.; Cory, K.

2013-10-01

Today's utility planners have a different market and economic context than their predecessors, including planning for the growth of renewable energy. State and federal support policies, solar photovoltaic (PV) price declines, and the introduction of new business models for solar PV 'ownership' are leading to increasing interest in solar technologies (especially PV); however, solar introduces myriad new variables into the utility resource planning decision. Most, but not all, utility planners have less experience analyzing solar than conventional generation as part of capacity planning, portfolio evaluation, and resource procurement decisions. To begin to build this knowledge, utility staff expressed interest in one effort: utility exchanges regarding data, methods, challenges, and solutions for incorporating solar in the planning process. Through interviews and a questionnaire, this report aims to begin this exchange of information and capture utility-provided information about: 1) how various utilities approach long-range resource planning; 2) methods and tools utilities use to conduct resource planning; and, 3) how solar technologies are considered in the resource planning process.

Utility of Combining a Simulation-Based Method With a Lecture-Based Method for Fundoscopy Training in Neurology Residency.

Science.gov (United States)

Gupta, Deepak K; Khandker, Namir; Stacy, Kristin; Tatsuoka, Curtis M; Preston, David C

2017-10-01

Fundoscopic examination is an essential component of the neurologic examination. Competence in its performance is mandated as a required clinical skill for neurology residents by the American Council of Graduate Medical Education. Government and private insurance agencies require its performance and documentation for moderate- and high-level neurologic evaluations. Traditionally, assessment and teaching of this key clinical examination technique have been difficult in neurology residency training. To evaluate the utility of a simulation-based method and the traditional lecture-based method for assessment and teaching of fundoscopy to neurology residents. This study was a prospective, single-blinded, education research study of 48 neurology residents recruited from July 1, 2015, through June 30, 2016, at a large neurology residency training program. Participants were equally divided into control and intervention groups after stratification by training year. Baseline and postintervention assessments were performed using questionnaire, survey, and fundoscopy simulators. After baseline assessment, both groups initially received lecture-based training, which covered fundamental knowledge on the components of fundoscopy and key neurologic findings observed on fundoscopic examination. The intervention group additionally received simulation-based training, which consisted of an instructor-led, hands-on workshop that covered practical skills of performing fundoscopic examination and identifying neurologically relevant findings on another fundoscopy simulator. The primary outcome measures were the postintervention changes in fundoscopy knowledge, skills, and total scores. A total of 30 men and 18 women were equally distributed between the 2 groups. The intervention group had significantly higher mean (SD) increases in skills (2.5 [2.3] vs 0.8 [1.8], P = .01) and total (9.3 [4.3] vs 5.3 [5.8], P = .02) scores compared with the control group. Knowledge scores (6.8 [3

Industrial coal utilization

Energy Technology Data Exchange (ETDEWEB)

None

1979-01-01

The effects of the National Energy Act on the use of coal in US industrial and utility power plants are considered. Innovative methods of using coal in an environmentally acceptable way are discussed: furnace types, fluidized-bed combustion, coal-oil-mixtures, coal firing in kilns and combustion of synthetic gas and liquid fuels. Fuel use in various industries is discussed with trends brought about by uncertain availability and price of natural gas and fuel oils: steel, chemical, cement, pulp and paper, glass and bricks. The symposium on Industrial Coal Utilization was sponsored by the US DOE, Pittsburgh Energy Technology Center, April 3 to 4, 1979. Twenty-one papers have been entered individually into the EDB. (LTN)

Simple noninvasive quantification method for measuring myocardial glucose utilization in humans employing positron emission tomography and fluorine-18 deoxyglucose

International Nuclear Information System (INIS)

Gambhir, S.S.; Schwaiger, M.; Huang, S.C.; Krivokapich, J.; Schelbert, H.R.; Nienaber, C.A.; Phelps, M.E.

1989-01-01

To estimate regional myocardial glucose utilization (rMGU) with positron emission tomography (PET) and 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG) in humans, we studied a method which simplifies the experimental procedure and is computationally efficient. This imaging approach uses a blood time-activity curve derived from a region of interest (ROI) drawn over dynamic PET images of the left ventricle (LV), and a Patlak graphic analysis. The spillover of radioactivity from the cardiac chambers to the myocardium is automatically removed by this analysis. Estimates of rMGU were obtained from FDG PET cardiac studies of six normal human subjects. Results from this study indicate that the FDG time-activity curve obtained from the LV ROI matched well with the arterial plasma curve. The rMGU obtained by Patlak graphic analysis was in good agreement with direct curve fitting results (r = 0.90). The average standard error of the estimate of the Patlak rMGU was low (3%). These results demonstrate the practical usefulness of a simplified method for the estimation of rMGU in humans by PET. This approach is noninvasive, computationally fast, and highly suited for developing parametric images of myocardial glucose utilization rate

Method for utilizing decay heat from radioactive nuclear wastes

International Nuclear Information System (INIS)

Busey, H.M.

1974-01-01

Management of radioactive heat-producing waste material while safely utilizing the heat thereof is accomplished by encapsulating the wastes after a cooling period, transporting the capsules to a facility including a plurality of vertically disposed storage tubes, lowering the capsules as they arrive at the facility into the storage tubes, cooling the storage tubes by circulating a gas thereover, employing the so heated gas to obtain an economically beneficial result, and continually adding waste capsules to the facility as they arrive thereat over a substantial period of time

Diagnosis method utilizing neural networks

International Nuclear Information System (INIS)

Watanabe, K.; Tamayama, K.

1990-01-01

Studies have been made on the technique of neural networks, which will be used to identify a cause of a small anomalous state in the reactor coolant system of the ATR (Advance Thermal Reactor). Three phases of analyses were carried out in this study. First, simulation for 100 seconds was made to determine how the plant parameters respond after the occurence of a transient decrease in reactivity, flow rate and temperature of feed water and increase in the steam flow rate and steam pressure, which would produce a decrease of water level in a steam drum of the ATR. Next, the simulation data was analysed utilizing an autoregressive model. From this analysis, a total of 36 coherency functions up to 0.5 Hz in each transient were computed among nine important and detectable plant parameters: neutron flux, flow rate of coolant, steam or feed water, water level in the steam drum, pressure and opening area of control valve in a steam pipe, feed water temperature and electrical power. Last, learning of neural networks composed of 96 input, 4-9 hidden and 5 output layer units was done by use of the generalized delta rule, namely a back-propagation algorithm. These convergent computations were continued as far as the difference between the desired outputs, 1 for direct cause or 0 for four other ones and actual outputs reached less than 10%. (1) Coherency functions were not governed by decreasing rate of reactivity in the range of 0.41x10 -2 dollar/s to 1.62x10 -2 dollar /s or by decreasing depth of the feed water temperature in the range of 3 deg C to 10 deg C or by a change of 10% or less in the three other causes. Change in coherency functions only depended on the type of cause. (2) The direct cause from the other four ones could be discriminated with 0.94+-0.01 of output level. A maximum of 0.06 output height was found among the other four causes. (3) Calculation load which is represented as products of learning times and numbers of the hidden units did not depend on the

Health-state utilities in a prisoner population: a cross-sectional survey

Directory of Open Access Journals (Sweden)

Levy Michael H

2009-08-01

Full Text Available Abstract Background Health-state utilities for prisoners have not been described. Methods We used data from a 1996 cross-sectional survey of Australian prisoners (n = 734. Respondent-level SF-36 data was transformed into utility scores by both the SF-6D and Nichol's method. Socio-demographic and clinical predictors of SF-6D utility were assessed in univariate analyses and a multivariate general linear model. Results The overall mean SF-6D utility was 0.725 (SD 0.119. When subdivided by various medical conditions, prisoner SF-6D utilities ranged from 0.620 for angina to 0.764 for those with none/mild depressive symptoms. Utilities derived by the Nichol's method were higher than SF-6D scores, often by more than 0.1. In multivariate analysis, significant independent predictors of worse utility included female gender, increasing age, increasing number of comorbidities and more severe depressive symptoms. Conclusion The utilities presented may prove useful for future economic and decision models evaluating prison-based health programs.

SU-E-T-492: Implementing a Method for Brain Irradiation in Rats Utilizing a Commercially Available Radiosurgery Irradiator

International Nuclear Information System (INIS)

Cates, J; Drzymala, R

2014-01-01

Purpose: The purpose of the study was to implement a method for accurate rat brain irradiation using the Gamma Knife Perfexion unit. The system needed to be repeatable, efficient, and dosimetrically and spatially accurate. Methods: A platform (“rat holder”) was made such that it is attachable to the Leskell Gamma Knife G Frame. The rat holder utilizes two ear bars contacting bony anatomy and a front tooth bar to secure the rat. The rat holder fits inside of the Leskell localizer box, which utilizes fiducial markers to register with the GammaPlan planning system. This method allows for accurate, repeatable setup.A cylindrical phantom was made so that film can be placed axially in the phantom. We then acquired CT image sets of the rat holder and localizer box with both a rat and the phantom. Three treatment plans were created: a plan on the rat CT dataset, a phantom plan with the same prescription dose as the rat plan, and a phantom plan with the same delivery time as the rat plan. Results: Film analysis from the phantom showed that our setup is spatially accurate and repeatable. It is also dosimetrically accurate, with an difference between predicted and measured dose of 2.9%. Film analysis with prescription dose equal between rat and phantom plans showed a difference of 3.8%, showing that our phantom is a good representation of the rat for dosimetry purposes, allowing for +/- 3mm diameter variation. Film analysis with treatment time equal showed an error of 2.6%, which means we can deliver a prescription dose within 3% accuracy. Conclusion: Our method for irradiation of rat brain has been shown to be repeatable, efficient, and accurate, both dosimetrically and spatially. We can treat a large number of rats efficiently while delivering prescription doses within 3% at millimeter level accuracy

Utility of the physical examination in detecting pulmonary hypertension. A mixed methods study.

Directory of Open Access Journals (Sweden)

Rebecca Colman

Full Text Available INTRODUCTION: Patients with pulmonary hypertension (PH often present with a variety of physical findings reflecting a volume or pressure overloaded right ventricle (RV. However, there is no consensus regarding the diagnostic utility of the physical examination in PH. METHODS: We conducted a systematic review of publications that evaluated the clinical examination and diagnosis of PH using MEDLINE (1946-2013 and EMBASE (1947-2013. We also prospectively evaluated the diagnostic utility of the physical examination findings. Patients who underwent right cardiac catheterization for any reason were recruited. After informed consent, participants were examined by 6 physicians (3 "specialists" and 3 "generalists" who were unaware of the results of the patient's hemodynamics. Each examiner independently assessed patients for the presence of a RV lift, loud P2, jugular venous distension (JVD, tricuspid insufficiency murmur and right-sided 4th heart sound at rest and during a slow inspiration. A global rating (scale of 1-5 of the likelihood that the patient had pulmonary hypertension was provided by each examiner. RESULTS: 31 articles that assessed the physical examination in PH were included in the final analysis. There was heterogeneity amongst the studies and many did not include control data. The sign most associated with PH in the literature was a loud pulmonic component of the second heart sound (P2. In our prospective study physical examination was performed on 52 subjects (25 met criteria for PH; mPAP ≥ 25 mmHg. The physical sign with the highest likelihood ratio (LR was a loud P2 on inspiration with a LR +ve 1.9, 95% CrI [1.2, 3.1] when data from all examiners was analyzed together. Results from the specialist examiners had higher diagnostic utility; a loud P2 on inspiration was associated with a positive LR of 3.2, 95% CrI [1.5, 6.2] and a right sided S4 on inspiration had a LR +ve 4.7, 95% CI [1.0, 15.6]. No aspect of the physical exam, could

Utility of the Physical Examination in Detecting Pulmonary Hypertension. A Mixed Methods Study

Science.gov (United States)

Colman, Rebecca; Whittingham, Heather; Tomlinson, George; Granton, John

2014-01-01

Introduction Patients with pulmonary hypertension (PH) often present with a variety of physical findings reflecting a volume or pressure overloaded right ventricle (RV). However, there is no consensus regarding the diagnostic utility of the physical examination in PH. Methods We conducted a systematic review of publications that evaluated the clinical examination and diagnosis of PH using MEDLINE (1946–2013) and EMBASE (1947–2013). We also prospectively evaluated the diagnostic utility of the physical examination findings. Patients who underwent right cardiac catheterization for any reason were recruited. After informed consent, participants were examined by 6 physicians (3 “specialists” and 3 “generalists”) who were unaware of the results of the patient's hemodynamics. Each examiner independently assessed patients for the presence of a RV lift, loud P2, jugular venous distension (JVD), tricuspid insufficiency murmur and right-sided 4th heart sound at rest and during a slow inspiration. A global rating (scale of 1–5) of the likelihood that the patient had pulmonary hypertension was provided by each examiner. Results 31 articles that assessed the physical examination in PH were included in the final analysis. There was heterogeneity amongst the studies and many did not include control data. The sign most associated with PH in the literature was a loud pulmonic component of the second heart sound (P2). In our prospective study physical examination was performed on 52 subjects (25 met criteria for PH; mPAP ≥25 mmHg). The physical sign with the highest likelihood ratio (LR) was a loud P2 on inspiration with a LR +ve 1.9, 95% CrI [1.2, 3.1] when data from all examiners was analyzed together. Results from the specialist examiners had higher diagnostic utility; a loud P2 on inspiration was associated with a positive LR of 3.2, 95% CrI [1.5, 6.2] and a right sided S4 on inspiration had a LR +ve 4.7, 95% CI [1.0, 15.6]. No aspect of the physical exam, could

ONTOLOGY-DRIVEN TOOL FOR UTILIZING PROGRAMMING STYLES

Directory of Open Access Journals (Sweden)

Nikolay Sidorov

2017-07-01

Full Text Available Activities of a programmer will be more effective and the software will be more understandable when within the process of software development, programming styles (standards are used, providing clarity of software texts. Purpose: In this research, we present the tool for the realization of new ontology-based methodology automated reasoning techniques for utilizing programming styles. In particular, we focus on representing programming styles in the form of formal ontologies, and study how description logic reasoner can assist programmers in utilizing programming standards. Our research hypothesis is as follows: ontological representation of programming styles can provide additional benefits over existing approaches in utilizing programmer of programming standards. Our research goal is to develop a tool to support the ontology-based utilizing programming styles. Methods: ontological representation of programming styles; object-oriented programming; ontology-driven utilizing of programming styles. Results: the architecture was obtained and the tool was developed in the Java language, which provide tool support of ontology-driven programming styles application method. On the example of naming of the Java programming language standard, features of implementation and application of the tool are provided. Discussion: application of programming styles in coding of program; lack of automated tools for the processes of programming standards application; tool based on new method of ontology-driven application of programming styles; an example of the implementation of tool architecture for naming rules of the Java language standard.

Calculating the marginal costs of a district-heating utility

International Nuclear Information System (INIS)

Sjoedin, Joergen; Henning, Dag

2004-01-01

District heating plays an important role in the Swedish heat-market. At the same time, the price of district heating varies considerably among different district-heating utilities. A case study is performed here in which a Swedish utility is analysed using three different methods for calculating the marginal costs of heat supply: a manual spreadsheet method, an optimising linear-programming model, and a least-cost dispatch simulation model. Calculated marginal-costs, obtained with the three methods, turn out to be similar. The calculated marginal-costs are also compared to the actual heat tariff in use by the utility. Using prices based on marginal costs should be able to bring about an efficient resource-allocation. It is found that the fixed rate the utility uses today should be replaced by a time-of-use rate, which would give a more accurate signal for customers to change their heat consumptions. (Author)

Automatic segmentation of MRI head images by 3-D region growing method which utilizes edge information

International Nuclear Information System (INIS)

Jiang, Hao; Suzuki, Hidetomo; Toriwaki, Jun-ichiro

1991-01-01

This paper presents a 3-D segmentation method that automatically extracts soft tissue from multi-sliced MRI head images. MRI produces a sequence of two-dimensional (2-D) images which contains three-dimensional (3-D) information of organs. To utilize such information we need effective algorithms to treat 3-D digital images and to extract organs and tissues of interest. We developed a method to extract the brain from MRI images which uses a region growing procedure and integrates information of uniformity of gray levels and information of the presence of edge segments in the local area around the pixel of interest. First we generate a kernel region which is a part of brain tissue by simple thresholding. Then we grow the region by means of a region growing algorithm under the control of 3-D edge existence to obtain the region of the brain. Our method is rather simple because it uses basic 3-D image processing techniques like spatial difference. It is robust for variation of gray levels inside a tissue since it also refers to the edge information in the process of region growing. Therefore, the method is flexible enough to be applicable to the segmentation of other images including soft tissues which have complicated shapes and fluctuation in gray levels. (author)

Utilization of Teeth Replacement Service Among the Elderly ...

African Journals Online (AJOL)

. However, its utilization by the elderly has not been extensively studied. Aim: To determine the utilization of tooth replacement services among the elderly. Materials and Methods: This was a retrospective study of 440 patients aged 60 years ...

Quantifying the utility of taking pills for cardiovascular prevention.

Science.gov (United States)

Hutchins, Robert; Viera, Anthony J; Sheridan, Stacey L; Pignone, Michael P

2015-03-01

The decrease in utility attributed to taking pills for cardiovascular prevention can have major effects on the cost-effectiveness of interventions but has not been well studied. We sought to measure the utility of daily pill-taking for cardiovascular prevention. We conducted a cross-sectional Internet-based survey of 1000 US residents aged ≥30 in March 2014. We calculated utility values, using time trade-off as our primary method and standard gamble and willingness-to-pay techniques as secondary analyses. Mean age of respondents was 50 years. Most were female (59%) and white (63%); 28% had less than a college degree; and 79% took ≥1 pills daily. Mean utility using the time trade-off method was 0.990 (95% confidence interval, 0.988-0.992), including ≈70% not willing to trade any amount of time to avoid taking a preventive pill daily. Using the standard gamble method, mean utility was 0.991 (0.989-0.993), with 62% not willing to risk any chance of death. Respondents were willing to pay an average of $1445 to avoid taking a pill daily, which translated to a mean utility of 0.994 (0.940-0.997), including 41% unwilling to pay any amount. Time trade-off-based utility varied by age (decreasing utility as age increased), sex, race, numeracy, difficulty with obtaining pills, and number of pills taken per day but did not vary by education level, literacy, or income. Mean utility for taking a pill daily for cardiovascular prevention is ≈0.990 to 0.994. © 2015 American Heart Association, Inc.

Nuclear magnetic resonance at 310 MHz in a superconducting solenoid; Resonance magnetique nucleaire a 310 MHz dans un solenoide supra-conducteur

Energy Technology Data Exchange (ETDEWEB)

Dunand, J J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1970-07-01

The realisation of an NMR spectrometer with a superconducting magnet is presented in the first section. The methods to attain the best possible homogeneity of the magnetic field and to minimize the error in the spectrometer are described. The second section is devoted to the study of elastomers and nitr-oxides free radicals. A shift of the transition temperature with the magnetic field appears for the elastomers. The increasing paramagnetic shift has allowed a complete study by NMR of piperidinic and pyrrolidinic nitroxide free radicals. (author) [French] Dans la premiere partie est exposee la realisation d'un spectrometre de RMN utilisant un solenoide supraconducteur. Des solutions sont donnees pour obtenir la meilleure homogeneite possible du champ magnetique et pour minimiser les sources d'erreur apportees par le spectrometre. La deuxieme partie est consacree a l'etude d'elastomeres et de radicaux libres nitroxydes. Une variation de la temperature de transition avec le champ magnetique est mise en evidence pour les elastomeres. L'accroissement du deplacement paramagnetique a permis une etude complete par RMN des radicaux libres nitroxydes piperidiniques et pyrrolidiniques. (auteur)

Energetic efficiency of complex substrate utilization by Trichoderma viride

Energy Technology Data Exchange (ETDEWEB)

Leite, M; Apine, A; Zeltina, M; Shvinka, J [AN Latvijskoj SSR, Riga (USSR). August Kirchstein Inst. of Microbiology

1989-01-01

The efficiency of carbon substrate utilization is evaluated as the thermodynamic efficiency (eta{sub x}) of microbial growth. Three methods based on mass-energy balance are used for the efficiency studies of complex substrates (straw, plant juices, lye) utilization by microfungi Trichoderma viride. 1. According to substrate and biomass balance eta{sub x}=0.55, 0.37 and 0.36 for Trichoderma viride growth on alkali pretreated wheat straw during 23, 34 and 50 hours. Cellulose biodegradation increases with cultivation time. However, the efficiency of cellulose utilization for cell mass growth decreases at the same time. 2. In accordance with oxygen-balance calculations eta{sub x}=0.75 and 0.71 for the same processes. The discrepancy in results from the above two methods probably can be explained by the following: A. Substrate and biomass balance gives underestimated results. B. Oxygen balance method includes the part of energy for extracellular product formation and therefore eta{sub x} can be overestimated. C. The efficiency of complex soluble substrate utilization (lye, green juice, deproteinized brown plant juice) tested by means of pulse method gives the values of eta{sub x}=0.72-0.88. Similar high estimates of eta{sub x} in C-limited batch culture are observed for soluble carbohydrates (glucose, galactose, lactose, xylose) but not for acetate. The pulse method is advantageous for testing the 'true' efficiency of carbon substrate utilization in a definite physiological environment. (orig.).

The development of uranium foil farication technology utilizing twin roll method for Mo-99 irradiation target

CERN Document Server

Kim, C K; Park, H D

2002-01-01

MDS Nordion in Canada, occupying about 75% of global supply of Mo-99 isotope, has provided the irradiation target of Mo-99 using the rod-type UAl sub x alloys with HEU(High Enrichment Uranium). ANL (Argonne National Laboratory) through co-operation with BATAN in Indonesia, leading RERTR (Reduced Enrichment for Research and Test Reactors) program substantially for nuclear non-proliferation, has designed and fabricated the annular cylinder of uranium targets, and successfully performed irradiation test, in order to develop the fabrication technology of fission Mo-99 using LEU(Low Enrichment Uranium). As the uranium foils could be fabricated in laboratory scale, not in commercialized scale by hot rolling method due to significant problems in foil quality, productivity and economic efficiency, attention has shifted to the development of new technology. Under these circumstances, the invention of uranium foil fabrication technology utilizing twin-roll casting method in KAERI is found to be able to fabricate LEU or...

Recyclable crosslinked polymer networks with full property recovery made via one-step controlled radical polymerization

Science.gov (United States)

Jin, Kailong; Li, Lingqiao; Torkelson, John

Rubber tires illustrate well the issues ranging from economic loss to environmental problems and sustainability issues that arise with spent, covalently crosslinked polymers. A nitroxide-mediated polymerization (NMP) strategy has been developed that allows for one-step synthesis of recyclable crosslinked polymers from monomers or polymers that contain carbon-carbon double bonds amenable to radical polymerization. Resulting materials possess dynamic alkoxyamine crosslinks that undergo reversible decrosslinking as a function of temperature. Using polybutadiene as starting material, and styrene, an appropriate nitroxide molecule and bifunctional initiator for initial crosslinking, a model for tire rubber can be produced by reaction at temperatures comparable to those employed in tire molding. Upon cooling, the crosslinks are made permanent due to the extraordinarily strong temperature dependence of the reverisible nitroxide capping and uncapping reaction. Based on thermomechanical property characterization, when the original crosslinked model rubber is chopped into bits and remolded in the melt state, a well-consolidated material is obtained which exhibits full recovery of properties reflecting crosslink density after multiple recycling steps.

Utilities of Patients with Hypertension in Northern Vietnam

NARCIS (Netherlands)

Nguyen, Thi-Phuong-Lan; Krabbe, Paul F. M.; Nguyen, Thi-Bach-Yen; Schuiling-Veninga, Catharina C. M.; Wright, E. Pamela; Postma, Maarten J.

2015-01-01

Objectives The study aims to inform potential cost-effectiveness analysis of hypertension management in Vietnam by providing utilities and predictors of utilities in patients with hypertension. Methods Hypertensive patients up to 80 years old visiting the hospital were invited to participate in a

Computer-Enhanced Visual Learning Method to Teach Endoscopic Correction of Vesicoureteral Reflux: An Invitation to Residency Training Programs to Utilize the CEVL Method

Directory of Open Access Journals (Sweden)

Michael Bauschard

2012-01-01

Full Text Available Herein we describe a standardized approach to teach endoscopic injection therapy to repair vesicoureteral reflux utilizing the CEVL method, an internet-accessed platform. The content was developed through collaboration of the authors' clinical and computer expertises. This application provides personnel training, examination, and procedure skill documentation through the use of online text with narration, pictures, and video. There is also included feedback and remediation of skill performance and teaching “games.” We propose that such standardized teaching and procedure performance will ultimate in improved surgical results. The electronic nature of communication in this journal is ideal to rapidly disseminate this information and to develop a structure for collaborative research.

Design for a sustainable society utilizing information and communication technologies (ICT) - proposal: a new EcoDesign method and its application

Energy Technology Data Exchange (ETDEWEB)

Fujimoto, J. [Research Center for Advanced Science and Technology, the Univ. of Tokyo (Japan); Matsumoto, M. [Fundamental and Environment Labs., NEC Corp. (Japan)

2004-07-01

We discuss a new EcoDesign method, with a goal of improving the economy, and its application to a sustainable networked society. The new EcoDesign method differs from conventional EcoDesign in three respects: it utilizes a top-down approach, project-style research, and fact-finding and benchmarking. We systematize EcoDesign for a networked society from the viewpoint of technology and divide it into four components. Feasibility studies of the individual components reveal that if we promote ICT diffusion with EcoDesign in mind, we can suppress CO2 emissions and move towards a more sustainable society. (orig.)

Immobilization of glucoamylase on ceramic membrane surfaces modified with a new method of treatment utilizing SPCP-CVD.

Science.gov (United States)

Ida; Matsuyama; Yamamoto

2000-07-01

Glucoamylase, as a model enzyme, was immobilized on a ceramic membrane modified by surface corona discharge induced plasma chemical process-chemical vapor deposition (SPCP-CVD). Characterizations of the immobilized enzyme were then discussed. Three kinds of ceramic membranes with different amounts of amino groups on the surface were prepared utilizing the SPCP-CVD method. Each with 1-time, 3-times and 5-times surface modification treatments and used for supports in glucoamylase immobilization. The amount of immobilized glucoamylase increased with the increase in the number of surface modification treatments and saturated to a certain maximum value estimated by a two-dimensional random packing. The operational stability of the immobilized glucoamylase also increased with the increase in the number of the surface treatment. It was almost the same as the conventional method, while the activity of immobilized enzyme was higher. The results indicated the possibility of designing the performance of the immobilized enzyme by controlling the amount of amino groups. The above results showed that the completely new surface modification method using SPCP was effective in modifying ceramic membranes for enzyme immobilization.

Practical constraints on fuel management a utility perspective

International Nuclear Information System (INIS)

Grier, C.A.

1986-01-01

The practical and potential constraints of performing fuel management at a large utility are reviewed. Based on approximately six years of experience in performing fuel management the constraints due to commercial, technical, utility system, design methods, and personnel and computer resources are discussed in detail

Non-streaming high-efficiency perforated semiconductor neutron detectors, methods of making same and measuring wand and detector modules utilizing same

Science.gov (United States)

McGregor, Douglas S.; Shultis, John K.; Rice, Blake B.; McNeil, Walter J.; Solomon, Clell J.; Patterson, Eric L.; Bellinger, Steven L.

2010-12-21

Non-streaming high-efficiency perforated semiconductor neutron detectors, method of making same and measuring wands and detector modules utilizing same are disclosed. The detectors have improved mechanical structure, flattened angular detector responses, and reduced leakage current. A plurality of such detectors can be assembled into imaging arrays, and can be used for neutron radiography, remote neutron sensing, cold neutron imaging, SNM monitoring, and various other applications.

Electric energy utilization and conservation

International Nuclear Information System (INIS)

Tripathy, S.C.

1991-01-01

Various aspects of electric energy utilization and conservation are discussed. First chapter reviews thermodynamic aspects of energy conservation. Subsequent chapters describe possibilities and methods of energy conservation in thermal power plants, airconditioning and ventilation systems, electric lighting systems, electric heating systems in industries, and railway electrification. Chapter 8 describes various modes of energy storage and compares their economies. The next chapter discusses various facets of energy economics and the last chapter discusses the practical aspects of energy conservation in different industries and power utilities. (M.G.B.). 100 refs

Renewable Energy Price-Stability Benefits in Utility Green Power Programs

Energy Technology Data Exchange (ETDEWEB)

Bird, L. A.; Cory, K. S.; Swezey, B. G.

2008-08-01

This paper examines utility experiences when offering the fixed-price benefits of renewable energy in green pricing programs, including the methods utilized and the impact on program participation. It focuses primarily on utility green pricing programs in states that have not undergone electric industry restructuring.

[Evaluation of TB-beads assay utilizing the technique of magnetic beads--an innovative assay method for detection of acid fast bacilli].

Science.gov (United States)

Ohkuma, Masanori; Ikeda, Katsuyoshi; Obayashi, Konen; Ando, Yukio; Koriyama, Toyoyasu; Kimu, Minhi; Hirose, Nobuyuki; Nagasawa, Zenzo; Miyamoto, Hiroshi

2012-01-01

The centrifuge method with the use of Semi-Alkalin Proteinase (SAP) and NALC-NaOH, recommended by the "2007 edition of the assay guideline for detection of Mycobacterium tuberculosis," has significantly contributed to improving the sensitivities and specificities of both smear and culture tests for detection of acid fast bacilli (AFB). However, this method poses some challenges in terms of its cumbersome and time-consuming assay protocol. "TB-beads (Kyokuto Pharmaceutical Industrial Co., Ltd.)" is a newly-developed method for detection of AFB utilizing magnetic beads. We evaluated the quality of this method in comparison with the centrifuge method, focusing on the results of smear and culture tests. This evaluation study was conducted using both 5 positive and 5 negative sputum samples. The sensitivity of TB-beads for fluorescent smear tests, conducted using "Acri-stain," was almost the same as that of the centrifuge method. One advantage of TB-beads, however, was that it was very convenient to practice microscopic observation due to the clear background of the smeared glass slides. The comparison of the contamination rates between the two methods showed that TB-beads suggested significantly lower contamination rates. The centrifuge method resulted in 50% and 60% of contamination rates for HK Semisolid Isolation Medium and BacT/ALERT MP, respectively. On the other hand, the contamination rates of TB-beads for both of the culture methods were only 10%. With regard to the 5 positive sputum samples, the comparison of the detection rates between the centrifuge and TB-Beads method was made utilizing Myco Acid, Ogawa K, and BacT/ALERT MP. The TB-Beads method suggested higher detection rates for Myco Acid and Ogawa K, while there were no significant differences between the two methods for BacT/ALERT MP (16-23 days). TB-beads is an easy method that allows to simplify the process of smear tests, and contributes to significantly reducing the contamination rate of culture

Utilization and determinants of modern family planning among ...

African Journals Online (AJOL)

kim

planning increases with women's education, and creating a conductive environment for ... Key words: Family planning, Modern methods, Utilization, Reproductive age, Partner discussion .... Traditional methods consist of periodic abstinence,.

Pareto utility

NARCIS (Netherlands)

Ikefuji, M.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.H.M.

2013-01-01

In searching for an appropriate utility function in the expected utility framework, we formulate four properties that we want the utility function to satisfy. We conduct a search for such a function, and we identify Pareto utility as a function satisfying all four desired properties. Pareto utility

AN EXPERIMENT IN MULTIATTRIBUTE UTILITY THEORY

OpenAIRE

Delforce, Robert J.; Hardaker, J. Brian

1985-01-01

A version of multiattribute utility theory is evaluated as an aid to social decision making using an Australian case study. A multiattribute utility function is assessed over the descriptive, discrete decision alternatives of the decision problem rather than over the risky consequences of the attributes as in the standard approach. The evaluation is made first from the perspective of the decision analysts as a test of the feasibility of the method, and second, from the perspective of social d...

Social Work Science and Knowledge Utilization

Science.gov (United States)

Marsh, Jeanne C.; Reed, Martena

2016-01-01

Objective: This article advances understanding of social work science by examining the content and methods of highly utilized or cited journal articles in social work. Methods: A data base of the 100 most frequently cited articles from 79 social work journals was coded and categorized into three primary domains: content, research versus…

[Utilities: a solution of a decision problem?].

Science.gov (United States)

Koller, Michael; Ohmann, Christian; Lorenz, Wilfried

2008-01-01

Utility is a concept that originates from utilitarianism, a highly influential philosophical school in the Anglo-American world. The cornerstone of utilitarianism is the principle of maximum happiness or utility. In the medical sciences, this utility approach has been adopted and developed within the field of medical decision making. On an operational level, utility is the evaluation of a health state or an outcome on a one-dimensional scale ranging from 0 (death) to 1 (perfect health). By adding the concept of expectancy, the graphic representation of both concepts in a decision tree results in the specification of expected utilities and helps to resolve complex medical decision problems. Criticism of the utility approach relates to the rational perspective on humans (which is rejected by a considerable fraction of research in psychology) and to the artificial methods used in the evaluation of utility, such as Standard Gamble or Time Trade Off. These may well be the reason why the utility approach has never been accepted in Germany. Nevertheless, innovative concepts for defining goals in health care are urgently required, as the current debate in Germany on "Nutzen" (interestingly translated as 'benefit' instead of as 'utility') and integrated outcome models indicates. It remains to be seen whether this discussion will lead to a re-evaluation of the utility approach.

An Utilization Method Cooperating ISO drawings and Bookmarks for NDE

Energy Technology Data Exchange (ETDEWEB)

Yoo, Hyun-Ju; Cho, Chan-Hee; Lee, Tae-Hun [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2015-05-15

The inspection of weld parts are performed with various non-destructive test methods such as AUT, VT, PT, ECT, etc. The results have been published in the report booklets. Moreover, huge amount of non-destructive inspection data and reports, which are produced from the '78 Kori 1 to newly constructed power plant, are stored in the management department and DDCC of each power plant. Because the data are not classified, it takes much time to find the corresponding non-destructive test results report of a specific unit of a power plant for a particular year. In addition, it is possibility to make human error because the report is written and submitted after finding manually the non-destructive test results for the concerning weld. When there is a dispute of the results of non-destructive inspection of a particular weld, analyzes the control center, a result of the power plant and the corresponding non-destructive inspection of a particular weld of ISO drawing in many places such as control center, corresponding power plant and CRI was discussed together will be to derive the final conclusion. For discussion, the person in charge of each site, looking for ISO drawings there is a result of the weld, in the past results history report of non-destructive testing for this, by searching the results of the welding site, telephone and E-mail disadvantage of complicated procedures if necessary to the discussion together in -mail is performed I have. In this paper, we describe the contents introduced the ISO drawings and Bookmark function is trying to complement these drawbacks. By applying the present invention utilization, find the ISO drawings manually when querying the results of the non-destructive inspection of past weld, which reduces the time to grasp the content of the non-destructive test results report.

In vitro photostability and photoprotection studies of a novel 'multi-active' UV-absorber.

Science.gov (United States)

Venditti, E; Spadoni, T; Tiano, L; Astolfi, P; Greci, L; Littarru, G P; Damiani, E

2008-08-01

This paper reports on the synthesis and properties of a new UV-absorber (OC-NO) based on the most popular UV filter worldwide, ethylhexyl methoxycinnamate (OMC) in which the methoxy group has been replaced with a pyrrolidine nitroxide bearing antioxidant activity. This sunscreen active has therefore both UV-absorbing and antioxidant properties which could ideally address both the UV-B and UV-A skin photo-damage. For broad-spectrum coverage, the combinations of OC-NO with two commonly used UV-A absorbers (BMDBM and DHHB) were also studied. The results obtained reveal that OC-NO: (a) is as photostable as OMC after UV-A exposure; (b) acts as free radical scavenger as demonstrated by EPR and chemical studies; (c) reduces UV-A and UV-A+BMDBM induced lipid peroxidation in liposomes and cells, measured as reduced TBARS levels and increased C11-BODIPY red fluorescence, respectively; (d) has comparable antioxidant activity to that of vitamin E and BHT commonly used in skin care formulations; (e) is non-cytotoxic to human skin fibroblasts as assessed with the MTT assay when exposed to increasing doses of UV-A; and (f) OC-NO+DHHB is a promising, photostable broad spectrum UV-filter combination that concomitantly reduces UV-induced free radical damage. These results suggest that nitroxide/antioxidant-based UV-absorbers may pave the way for the utilization of 'multi-active' ingredients in sunscreens thereby reducing the number of ingredients in these formulations.

Neutron diffraction utilizing the T-O-F method

Energy Technology Data Exchange (ETDEWEB)

Niimura, N [Tohoku Univ., Sendai (Japan). Lab. of Nuclear Science

1974-12-01

Characteristic features of the TOF (time of flight) neutron diffraction are summarized. In this method, i) all the reciprocal points on the rod passing through the origin in the reciprocal space can be scanned by each burst of white neutrons, ii) it is easy to measure high index reflections at the large scattering angle, iii) each reflection is not affected by the higher-order harmonics, and iv) it is easy to measure the physical properties depending on the neutron wavelength. The pulse neutron generator as well as the data acquisition system in the Laboratory of Nuclear Science of Tohoku University is described. The TOF method seems to be very powerful if it is applied to accurate structure analysis. The data correction methods are discussed. The TOF method is prospective to the study of transient phenomena. In this method one can apply to the crystalline sample an external field pulsed with the same frequency as the neutrons. By using this method, the transient state of the polarization reversal of the ferroelectric NaNO/sub 2/ has been observed. The magnetically pulsed neutron TOF spectrometer is briefly introduced after a review of the chopper history.

Decision support for utility environmental risk management

International Nuclear Information System (INIS)

Balson, W.E.; Wilson, D.S.

1991-01-01

This paper reviews a number of decision support methods developed and applied by Decision Focus Incorporated to help utility personnel manage current environmental problems. This work has been performed for the Environmental Risk Analysis Program of EPRI's Environment Division, and also for a number of electric utilities across the country. These are two distinct types of decision support software tools that have been created: economic risk management and environmental risk analysis. These types differ primarily in the identification of who will make a decision. Economic risk management tools are directed primarily at decisions made by electric utilities. Environmental risk analysis tools are directed primarily at decisions made by legislative or regulatory agencies, about which a utility may wish to comment

Utilization of renewable energy in architectural design

Institute of Scientific and Technical Information of China (English)

TIAN Lei; QIN Youguo

2007-01-01

Renewable energy does not simply equal to using a photovoltaic (PV) board.In addition to heating,ventilation and air conditioning (HVAC) engineering considerations,the design approaches of architects are crucial to the utilization condition and methods of renewable energy.Through profound comprehension of the relationship between renewable energy utilization and design approaches,we can achieve a dual-standard of building environment performance and esthetics.

Evaluation of Antibacterial Utilization in Olabisi Onabanjo University ...

African Journals Online (AJOL)

This is particularly important as most hospitals in the country if not all have neglected the Drug Utilization Review aspects of Drug and Therapeutic Committee roles. It can also form basis for intervention be it educational, managerial or regulatory. METHODS: It is a retrospective drug utilization review studies, in addition a ...

Pain Scores Are Not Predictive of Pain Medication Utilization

Directory of Open Access Journals (Sweden)

Suzanne Galloway

2011-01-01

Full Text Available Objective. To compare Visual Analogue Scale (VAS scores with overall postoperative pain medication requirements including cumulative dose and patterns of medication utilization and to determine whether VAS scores predict pain medication utilization. Methods. VAS scores and pain medication data were collected from participants in a randomized trial of the utility of phenazopyridine for improved pain control following gynecologic surgery. Results. The mean age of the 219 participants was 54 (range19 to 94. We did not detect any association between VAS and pain medication utilization for patient-controlled anesthesia (PCA or RN administered (intravenous or oral medications. We also did not detect any association between the number of VAS scores recorded and mean pain scores. Conclusion. Postoperative VAS scores do not predict pain medication use in catheterized women inpatients following gynecologic surgery. Increased pain severity, as reflected by higher VAS scores, is not associated with an increase in pain assessment. Our findings suggest that VAS scores are of limited utility for optimal pain control. Alternative or complimentary methods may improve pain management.

Comparative analysis of methods for measurements of food intake and utilization using the soybean looper, Pseudoplusia includens and artificial media

International Nuclear Information System (INIS)

Parra, J.R.P.; Kogan, M.; Illinois Agricultural Experiment Station, Urbana; Illinois Univ., Urbana

1981-01-01

An analysis of intake and utilization of an artificial medium by larvae of the soybean looper, Pseudoplusia includens Walker, Lepidoptera: Noctuidae, was performed using 4 methods: standard gravimetric, chromic oxide, Calco Oil Red, and 14 C-glucose. Each method was used in conjunction with standard gravimetry. The relative merits of the indirect methods were analyzed in terms of precision and accuracy for ECI and ECD estimation, cost, and overall versatility. Only the gravimetric method combined ca. 80% precision in ECI and ECD estimation with low cost and maximum versatility. Calco Oil Red at 0.1% w/v was detrimental to the larvae. Cr 2 O 3 caused reduced intake but conversion was increased resulting in normal development and growth of larvae. The radioisotopic method had the advantage of providing a direct means of measuring expired CO 2 . The need to operate under a totally enclosed system, however, poses some serious difficulties in the use of radioisotopes. There seems to be little advantage in any of the proposed indirect methods, except if there are unusual difficulties in separating the excreta from the medium. (orig.)

Measuring Health Utilities in Children and Adolescents: A Systematic Review of the Literature.

Directory of Open Access Journals (Sweden)

Dominic Thorrington

Full Text Available The objective of this review was to evaluate the use of all direct and indirect methods used to estimate health utilities in both children and adolescents. Utilities measured pre- and post-intervention are combined with the time over which health states are experienced to calculate quality-adjusted life years (QALYs. Cost-utility analyses (CUAs estimate the cost-effectiveness of health technologies based on their costs and benefits using QALYs as a measure of benefit. The accurate measurement of QALYs is dependent on using appropriate methods to elicit health utilities.We sought studies that measured health utilities directly from patients or their proxies. We did not exclude those studies that also included adults in the analysis, but excluded those studies focused only on adults.We evaluated 90 studies from a total of 1,780 selected from the databases. 47 (52% studies were CUAs incorporated into randomised clinical trials; 23 (26% were health-state utility assessments; 8 (9% validated methods and 12 (13% compared existing or new methods. 22 unique direct or indirect calculation methods were used a total of 137 times. Direct calculation through standard gamble, time trade-off and visual analogue scale was used 32 times. The EuroQol EQ-5D was the most frequently-used single method, selected for 41 studies. 15 of the methods used were generic methods and the remaining 7 were disease-specific. 48 of the 90 studies (53% used some form of proxy, with 26 (29% using proxies exclusively to estimate health utilities.Several child- and adolescent-specific methods are still being developed and validated, leaving many studies using methods that have not been designed or validated for use in children or adolescents. Several studies failed to justify using proxy respondents rather than administering the methods directly to the patients. Only two studies examined missing responses to the methods administered with respect to the patients' ages.

Utilizing a Photo-Analysis Software for Content Identifying Method (CIM

Directory of Open Access Journals (Sweden)

Nejad Nasim Sahraei

2015-01-01

Full Text Available Content Identifying Methodology or (CIM was developed to measure public preferences in order to reveal the common characteristics of landscapes and aspects of underlying perceptions including the individual's reactions to content and spatial configuration, therefore, it can assist with the identification of factors that influenced preference. Regarding the analysis of landscape photographs through CIM, there are several studies utilizing image analysis software, such as Adobe Photoshop, in order to identify the physical contents in the scenes. This study attempts to evaluate public’s ‘preferences for aesthetic qualities of pedestrian bridges in urban areas through a photo-questionnaire survey, in which respondents evaluated images of pedestrian bridges in urban areas. Two groups of images were evaluated as the most and least preferred scenes that concern the highest and lowest mean scores respectively. These two groups were analyzed by CIM and also evaluated based on the respondent’s description of each group to reveal the pattern of preferences and the factors that may affect them. Digimizer Software was employed to triangulate the two approaches and to determine the role of these factors on people’s preferences. This study attempts to introduce the useful software for image analysis which can measure the physical contents and also their spatial organization in the scenes. According to the findings, it is revealed that Digimizer could be a useful tool in CIM approaches through preference studies that utilizes photographs in place of the actual landscape in order to determine the most important factors in public preferences for pedestrian bridges in urban areas.

Determinants of long acting and permanent contraceptive methods utilization among married women of reproductive age groups in western Ethiopia: a cross-sectional study.

Science.gov (United States)

Melka, Alemu Sufa; Tekelab, Tesfalidet; Wirtu, Desalegn

2015-01-01

In Ethiopia information on the level of utilization of the long term and permanent contraceptive methods and associated factorsis lacking. The aim of this study was to understand the determinant factors of long acting and permanent contraceptive methods use among married women of reproductive age in Western Ethiopia. A community based cross-sectional study design was employed. Multi stage sampling was used to select 1003 study participants. Data was collected from April 10 to April 25,2014 using a pre- tested structured questionnaire. The data were entered using Epi-info version 3.5.1 and exported to SPSS version 20 for analysis. Multivariate logistic regression analysis was done to identify predictors of long acting and permanent contraceptive methods at 95% CL. Use of long acting and permanent contraceptive methods in this study was found to be 20%. Survey results showed a significant positive association between utilization of long acting and permanent contraceptive methods and women's education (AOR=1.72, 95%CI=1.02-3.05), women's occupation (AOR=2.01, 95% CI=1.11-3.58), number of live children (AOR=2.42, 95% CI: 1.46-4.02), joint fertility related decision (AOR=6.11, 95% CI: 2.29-16.30), having radio/TV (AOR=2.31, 95% CI: 1.40-3.80), and discussion with health care provider about long acting and permanent contraceptive methods (AOR=13.72, 95% CI: 8.37-22.47). Efforts need to be aimed at women empowerment, health education, and encouraging open discussion of family planning by couples.

Integration of SPS with utility system networks

Science.gov (United States)

Kaupang, B. M.

1980-01-01

The integration of Satellite Power System (SPS) power in electric utility power systems is discussed. Specifically, the nature of the power output variations from the spacecraft to the rectenna, the operational characteristics of the rectenna power, and the impacts on the electric utility system from utilizing SPS power to serve part of the system load are treated. It is concluded that if RF beam control is an acceptable method for power control, and that the site distribution of SPS rectennas do not cause a very high local penetration (40 to 50%), SPS may be integrated into electric utility system with a few negative impacts. Increased regulating duty on the conventional generation, and a potential impact on system reliability for SPS penetration in excess of about 25% appear to be two areas of concern.

Health Service Utilization in Amhara Region of Ethiopia | Fantahun ...

African Journals Online (AJOL)

Background: Information on health service utilization is crucial for planning, organizing and evaluation of health services. Objective: Assess perceived morbidity and examine the factors associated with utilization of health services by a sample of the population of the Amhara Region. Methods: Questionnaire was ...

Long term plan of atomic energy development and utilization

International Nuclear Information System (INIS)

1982-01-01

The atomic energy utilization and development in Japan have progressed remarkably, and already nuclear power generation has borne an important part in electric power supply, while radiation has been utilized in the fields of industry, agriculture, medicine and so on. Now, atomic energy is indispensable for national life and industrial activity. The former long term plan was decided in September, 1978, and the new long term plan should be established since the situation has changed largely. The energy substituting for petroleum has been demanded, and the expectation to nuclear power generation has heightened because it enables stable and economical power supply. The independently developed technology related to atomic energy must be put in practical use. The peaceful utilization of atomic energy must be promoted, while contributing to the nuclear non-proliferation policy. The Atomic Energy Commission of Japan decided the new long term plan to clearly show the outline of the important measures related to atomic energy development and utilization in 10 years hereafter, and the method of its promotion. The basic concept of atomic energy development and utilization, the long term prospect and the concept on the promotion, the method of promoting the development and utilization, and the problems of funds, engineers and location are described. (kako, I.)

Method of preparing and utilizing a catalyst system for an oxidation process on a gaseous hydrocarbon stream

Science.gov (United States)

Berry, David A; Shekhawat, Dushyant; Smith, Mark; Haynes, Daniel

2013-07-16

The disclosure relates to a method of utilizing a catalyst system for an oxidation process on a gaseous hydrocarbon stream with a mitigation of carbon accumulation. The system is comprised of a catalytically active phase deposited onto an oxygen conducting phase, with or without supplemental support. The catalytically active phase has a specified crystal structure where at least one catalytically active metal is a cation within the crystal structure and coordinated with oxygen atoms within the crystal structure. The catalyst system employs an optimum coverage ratio for a given set of oxidation conditions, based on a specified hydrocarbon conversion and a carbon deposition limit. Specific embodiments of the catalyst system are disclosed.

Inspection Method for Contact Condition of Soil on the Surface of Underground Pipe Utilizing Resonance of Transverse Lamb Wave

Science.gov (United States)

Tanigawa, Hiroshi; Seno, Hiroaki; Watanabe, Yoshiaki; Nakajima, Koshiro

1998-05-01

A nondestructive inspection method to estimate the contact condition of soil on the surface of an underground pipe, utilizing the resonance of a transverse Lamb wave circulating along the pipe wall is proposed.The Q factor of the resonance is considered and measured under some contact conditions by sweeping the vibrating frequency in a 150-mm-inner diameter Fiberglass Reinforced Plastic Mortar (FRPM) pipe. It is confirmed that the Q factor shows a clear response to the change in the contact conditions. For example, the Q factor is 8.4 when the pipe is in ideal contact with the soil plane and goes up to 19.2 when a 100-mm-diameter void is located at the contact surface of the soil.The spatial resolution of the proposed inspection method is also measured by moving the sensing point along the direction of laying the length of the pipe into a 85-mm-diameter void. The resolution of the proposed method is estimated at about 50 mm.

Utilization of large electromagnetic pumps in the fast breeder reactors

International Nuclear Information System (INIS)

Deverge, C.; Lefrere, J.P.; Peturaud, P.; Sauvage, M.

1984-04-01

After an overview concerning the induction annular electromagnetic pumps and the dimensioning methods usually utilized, development of these components for a fast breeder integrated reactor is considered: - utilization of cooled EMP in the intermediate circuit, - utilization of immersed pumps, coupled with the intermediate exchanger, for the primary pumping; dimensioning, energetic aspects, and effects on the power plant geometrical configurations [fr

Maximize Minimum Utility Function of Fractional Cloud Computing System Based on Search Algorithm Utilizing the Mittag-Leffler Sum

Directory of Open Access Journals (Sweden)

Rabha W. Ibrahim

2018-01-01

Full Text Available The maximum min utility function (MMUF problem is an important representative of a large class of cloud computing systems (CCS. Having numerous applications in practice, especially in economy and industry. This paper introduces an effective solution-based search (SBS algorithm for solving the problem MMUF. First, we suggest a new formula of the utility function in term of the capacity of the cloud. We formulate the capacity in CCS, by using a fractional diffeo-integral equation. This equation usually describes the flow of CCS. The new formula of the utility function is modified recent active utility functions. The suggested technique first creates a high-quality initial solution by eliminating the less promising components, and then develops the quality of the achieved solution by the summation search solution (SSS. This method is considered by the Mittag-Leffler sum as hash functions to determine the position of the agent. Experimental results commonly utilized in the literature demonstrate that the proposed algorithm competes approvingly with the state-of-the-art algorithms both in terms of solution quality and computational efficiency.

Nuclear magnetic resonance at 310 MHz in a superconducting solenoid; Resonance magnetique nucleaire a 310 MHz dans un solenoide supra-conducteur

Energy Technology Data Exchange (ETDEWEB)

Dunand, J.J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1970-07-01

The realisation of an NMR spectrometer with a superconducting magnet is presented in the first section. The methods to attain the best possible homogeneity of the magnetic field and to minimize the error in the spectrometer are described. The second section is devoted to the study of elastomers and nitr-oxides free radicals. A shift of the transition temperature with the magnetic field appears for the elastomers. The increasing paramagnetic shift has allowed a complete study by NMR of piperidinic and pyrrolidinic nitroxide free radicals. (author) [French] Dans la premiere partie est exposee la realisation d'un spectrometre de RMN utilisant un solenoide supraconducteur. Des solutions sont donnees pour obtenir la meilleure homogeneite possible du champ magnetique et pour minimiser les sources d'erreur apportees par le spectrometre. La deuxieme partie est consacree a l'etude d'elastomeres et de radicaux libres nitroxydes. Une variation de la temperature de transition avec le champ magnetique est mise en evidence pour les elastomeres. L'accroissement du deplacement paramagnetique a permis une etude complete par RMN des radicaux libres nitroxydes piperidiniques et pyrrolidiniques. (auteur)

Hierarchical representation and utilization of plant constitution knowledge

International Nuclear Information System (INIS)

Nishizawa, Y.; Asami, K.

1990-01-01

A method to represent and utilize plant constitution knowledge is described. A plant system is divided into many subsystems and hierarchically represented using frames. The frames include the slots of an upper-system, lower-systems and components' connections. Connections are divided into subsystems external connections and internal connections. This knowledge representation allows top-down analysis of the plant constitution and components' connectivities. The data are edited by drawing plant diagrams on a CRT and converting them into frames. The frame data area verified by checking upper-lower relationships and components' connectivities. As an example of knowledge utilization a method to find a components' connection route is described. This method prevents the combinatorial explosion of components' connections by finding rough routes in advance of detailed route analysis

Systematic Field Study of NO(x) Emission Control Methods for Utility Boilers.

Science.gov (United States)

Bartok, William; And Others

A utility boiler field test program was conducted. The objectives were to determine new or improved NO (x) emission factors by fossil fuel type and boiler design, and to assess the scope of applicability of combustion modification techniques for controlling NO (x) emissions from such installations. A statistically designed test program was…

Dental Care Utilization for Examination and Regional Deprivation

Science.gov (United States)

Kim, Cheol-Sin; Han, Sun-Young; Lee, Seung Eun; Kang, Jeong-Hee; Kim, Chul-Woung

2015-01-01

Objectives: Receiving proper dental care plays a significant role in maintaining good oral health. We investigated the relationship between regional deprivation and dental care utilization. Methods: Multilevel logistic regression was used to identify the relationship between the regional deprivation level and dental care utilization purpose, adjusting for individual-level variables, in adults aged 19+ in the 2008 Korean Community Health Survey (n=220 258). Results: Among Korean adults, 12.8% used dental care to undergo examination and 21.0% visited a dentist for other reasons. In the final model, regional deprivation level was associated with significant variations in dental care utilization for examination (pdental care utilization for other reasons in the final model. Conclusions: This study’s findings suggest that policy interventions should be considered to reduce regional variations in rates of dental care utilization for examination. PMID:26265665

Additive conjoint measurement for multiattribute utility

NARCIS (Netherlands)

Maas, A.; Wakker, P.P.

1994-01-01

This paper shows that multiattribute utility can be simplified by methods from additive conjoint measurement. Given additive conjoint measurability under certainty, axiomatizations can be simplified, and implementation and reliability of elicitation can be improved. This also contributes to the

Utility Interfaced Pulse-Width Modulation of Solar Fed Voltage ...

African Journals Online (AJOL)

Utility Interfaced Pulse-Width Modulation of Solar Fed Voltage Source Inverter Using Fixed-Band Hysteresis Current Controller Method. ... with the conversion of solar energy into electrical energy; boosting the dc power; inversion of the dc to ac and then synchronization of the inverter output with the utility, and consequently, ...

UTILIZATION OF PLANT PROTEINS IN FUNCTIONAL NUTRITION

Directory of Open Access Journals (Sweden)

V. G. Kulakov

2017-01-01

Full Text Available Development of functional food products technology is considered to be a prospect way for creating new food products. Such products are known to be popular among consumers. Utilization of plant proteins allows to widen and improve food assortment and quality. The article represents a review of plant proteins utilization in production of functional food. For optimization of flour confectionery chemical composition the authors utilized a method of receipts modeling. Simulation of combined products is based on the principles of food combinatorics and aims to create recipes of new types of food products on basis of methods of mathematical optimization by reasonable selection of the basic raw materials, ingredients, food additives and dietary supplements, totality of which ensures formation desired organoleptic, physical and chemical properties product as well as a predetermined level of food, biological and energy value. Modeling process of combined products recipes includes the following three stages: preparation of input data for the design, formalization requirements for the composition and properties of raw ingredients and quality final product, process modeling; product design with desired structural properties.

A bayesian approach to laboratory utilization management

Directory of Open Access Journals (Sweden)

Ronald G Hauser

2015-01-01

Full Text Available Background: Laboratory utilization management describes a process designed to increase healthcare value by altering requests for laboratory services. A typical approach to monitor and prioritize interventions involves audits of laboratory orders against specific criteria, defined as rule-based laboratory utilization management. This approach has inherent limitations. First, rules are inflexible. They adapt poorly to the ambiguity of medical decision-making. Second, rules judge the context of a decision instead of the patient outcome allowing an order to simultaneously save a life and break a rule. Third, rules can threaten physician autonomy when used in a performance evaluation. Methods: We developed an alternative to rule-based laboratory utilization. The core idea comes from a formula used in epidemiology to estimate disease prevalence. The equation relates four terms: the prevalence of disease, the proportion of positive tests, test sensitivity and test specificity. When applied to a laboratory utilization audit, the formula estimates the prevalence of disease (pretest probability [PTP] in the patients tested. The comparison of PTPs among different providers, provider groups, or patient cohorts produces an objective evaluation of laboratory requests. We demonstrate the model in a review of tests for enterovirus (EV meningitis. Results: The model identified subpopulations within the cohort with a low prevalence of disease. These low prevalence groups shared demographic and seasonal factors known to protect against EV meningitis. This suggests too many orders occurred from patients at low risk for EV. Conclusion: We introduce a new method for laboratory utilization management programs to audit laboratory services.

Factors associated with adolescent mental health service need and utilization

NARCIS (Netherlands)

Zwaanswijk, Marieke; Ende, J. van der; Verhaak, P.F.M.; Bensing, J.; Verhulst, F.C.

2003-01-01

Objective: To determine the association of parent, family, and adolescent variables with adolescent mental health service need and utilization. Method: Correlates of adolescent mental health service utilization, self-perceived need and unmet need were investigated in a general population sample of

Tank Operations Contract Construction Management Methodology. Utilizing The Agency Method Of Construction Management To Safely And Effectively Complete Nuclear Construction Work

International Nuclear Information System (INIS)

Leso, K.F.; Hamilton, H.M.; Farner, M.; Heath, T.

2010-01-01

Washington River Protection Solutions, LLC (WRPS) has faced significant project management challenges in managing Davis-Bacon construction work that meets contractually required small business goals. The unique challenge is to provide contracting opportunities to multiple small business construction subcontractors while performing high hazard work in a safe and productive manner. Previous to the Washington River Protection Solutions, LLC contract, Construction work at the Hanford Tank Farms was contracted to large companies, while current Department of Energy (DOE) Contracts typically emphasize small business awards. As an integral part of Nuclear Project Management at Hanford Tank Farms, construction involves removal of old equipment and structures and installation of new infrastructure to support waste retrieval and waste feed delivery to the Waste Treatment Plant. Utilizing the optimum construction approach ensures that the contractors responsible for this work are successful in meeting safety, quality, cost and schedule objectives while working in a very hazardous environment. This paper describes the successful transition from a traditional project delivery method that utilized a large business general contractor and subcontractors to a new project construction management model that is more oriented to small businesses. Construction has selected the Agency Construction Management Method. This method was implemented in the first quarter of Fiscal Year (FY) 2009, where Construction Management is performed by substantially home office resources from the URS Northwest Office in Richland, Washington. The Agency Method has allowed WRPS to provide proven Construction Managers and Field Leads to mentor and direct small business contractors, thus providing expertise and assurance of a successful project. Construction execution contracts are subcontracted directly by WRPS to small or disadvantaged contractors that are mentored and supported by DRS personnel. Each small

TANK OPERATIONS CONTRACT CONSTRUCTION MANAGEMENT METHODOLOGY UTILIZING THE AGENCY METHOD OF CONSTRUCTION MANAGEMENT TO SAFELY AND EFFECTIVELY COMPLETE NUCLEAR CONSTRUCTION WORK

Energy Technology Data Exchange (ETDEWEB)

LESO KF; HAMILTON HM; FARNER M; HEATH T

2010-01-14

Washington River Protection Solutions, LLC (WRPS) has faced significant project management challenges in managing Davis-Bacon construction work that meets contractually required small business goals. The unique challenge is to provide contracting opportunities to multiple small business construction subcontractors while performing high hazard work in a safe and productive manner. Previous to the Washington River Protection Solutions, LLC contract, Construction work at the Hanford Tank Farms was contracted to large companies, while current Department of Energy (DOE) Contracts typically emphasize small business awards. As an integral part of Nuclear Project Management at Hanford Tank Farms, construction involves removal of old equipment and structures and installation of new infrastructure to support waste retrieval and waste feed delivery to the Waste Treatment Plant. Utilizing the optimum construction approach ensures that the contractors responsible for this work are successful in meeting safety, quality, cost and schedule objectives while working in a very hazardous environment. This paper describes the successful transition from a traditional project delivery method that utilized a large business general contractor and subcontractors to a new project construction management model that is more oriented to small businesses. Construction has selected the Agency Construction Management Method. This method was implemented in the first quarter of Fiscal Year (FY) 2009, where Construction Management is performed by substantially home office resources from the URS Northwest Office in Richland, Washington. The Agency Method has allowed WRPS to provide proven Construction Managers and Field Leads to mentor and direct small business contractors, thus providing expertise and assurance of a successful project. Construction execution contracts are subcontracted directly by WRPS to small or disadvantaged contractors that are mentored and supported by DRS personnel. Each small

Effect of thyrotropin-releasing hormone (TRH) on local cerebral glucose utilization, by the autoradiographic 2-deoxy [14C] glucose method, in conscious and pentobarbitalized rats

International Nuclear Information System (INIS)

Nagai, Y.; Narumi, S.; Nagawa, Y.; Sakurada, O.; Ueno, H.; Ishii, S.

1980-01-01

Effects of TRH and pentobarbital alone, and in combination, on local cerebral glucose utilization of rats were studied by the autoradiographic 2-deoxy[ 14 C] glucose method. TRH (5 mg/kg i.v.) reduced the rate of cerebral glucose utilization slightly in the whole brain. Locally, significant depression was observed in the following structures: frontal and visual cortices, hippocampus Ammon's horn and dentate gyrus, medial and lateral geniculate bodies, nucleus accumbens, caudate-putamen, substantia nigra, pontine gray matter, superior colliculus, superior olivary nucleus, vestibular nucleus, lateral lemniscus and cerebellar cortex. Pentobarbital (30 mg/kg i.v.) produced a marked and diffuse reduction in the rate of glucose utilization throughout the brain. TRH given 15 min after the administration of pentobarbital markedly shortened the pentobarbital sleeping time and caused some reversal of the depression in local cerebral glucose utilization produced by pentobarbital., These effects were almost completely abolished by pretreatment with intracerebroventricular injection of atropine methyl bromide (20 μg/rat). These results indicate that although TRH acts to cause a reduction in the rate of cerebral glucose utilization, it reverses the depression induced by pentobarbital, via a cholinergic mechanism, in a number of structures, some of which are related to monoaminergic systems and the reticulo-thalamo-cortical activating system. (author)

Economic Valuation on Change of Tourism Quality in Rawapening, Indonesia: An Application of Random Utility Method

Science.gov (United States)

Subanti, S.; Irawan, B. R. M. B.; Sasongko, G.; Hakim, A. R.

2017-04-01

This study aims to determine the profit (loss) earned economic actors tourism activities if the condition or quality of tourism in Rawapening be improved (deteriorated). Change condition or quality can be seen by traveling expenses, natural environment, Japanese cultural performances, and traditional markets. The method used to measure changes in the economic benefits or economic loss with a random utility approach. The study was found that travel cost, natural environment, Japanese cultural performances, and traditional markets have significant factors about respondent preferences to choose the change of tourism condition. The value of compensation received by visitors as a result of changes in conditions improved by 2,932 billion, while the change in the condition worsens by 2,628 billion. Recommendation of this study is the local government should consider environmental factors in the formulation of tourism development in Rawapening.

Understanding the unbundled utility conservation bidding proposal

International Nuclear Information System (INIS)

Joskow, P.L.

1990-01-01

For several years regulatory advisers have been engaged in controversy about the propriety of integrating energy conservation measures into the total resource planning processes of electric utilities, and of proposed methods of doing so in the competitive supply procurement programs which have been initiated by some utilities. Two prominent economists conceived a method for doing this in competitive bidding programs and at the same time overcoming objections to previous proposals which were based on perceived violations of basic economic principles. They explained their concept and its operation in an article published here in June of last year. In this article another economist subjects the concept to further analysis, identifying its essential elements, and point to inevitable results of their application

Utilization of MVP for research on fast reactor

International Nuclear Information System (INIS)

Yokoyama, Kenji

2001-01-01

Utilization of the continuous energy Monte-Carlo code, MVP, for research on fast reactor in Power Reactor and Nuclear Fuel Development Corporation(PNC) is described. In this report, three types of utilization are reviewed; (1) a comparison of the eigenvalues calculated by MVP with the results by the deterministic methods, (2) an improvement of U-238 reaction rate evaluation in JUPITER experimental Analysis and (3) an evaluation of heterogeneity effects for Am reaction rates of the moderated subassemblies. Since the results of MVP can be used as references, MVP is very useful code in research on fast reactor. It is one of indispensable tools in order to verify the models in the deterministic methods. Furthermore, it can be used so as to investigate the new concept reactors, such as a reactor aiming to transmute minor actinides(MA). On the other hand, a problem of the variance reduction remains. Especially, a small reactivity cannot be estimated by MVP because of large variances. The development of a Monte-Carlo method for a small reactivity calculation will promote the utilization of MVP for research on fast reactor. (author)

Renewable Energy Price-Stability Benefits in Utility Green Power Programs. 36 pp

Energy Technology Data Exchange (ETDEWEB)

Bird, Lori A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cory, Karlynn S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Swezey, Blair G. [Applied Materials, Santa Clara, CA (United States)

2008-08-01

This paper examines utility experiences when offering the fixed-price benefits of renewable energy in green pricing programs, including the methods utilized and the impact on program participation. It focuses primarily on utility green pricing programs in states that have not undergone electric industry restructuring.

Free radicals imaged in vivo in the rat by using proton-electron double-resonance imaging

International Nuclear Information System (INIS)

Lurie, D.J.; Nicholson, Ian; Foster, M.A.; Mallard, J.R.

1990-01-01

A new technique called proton-electron double-resonance imaging is described for imaging free radicals in aqueous samples. The method is a combination of proton NMR imaging with nuclear electron double resonance. The results of using this technique to image free radicals in vivo in the rat are presented. Rats were injected intravenously with a nitroxide free radical solution and a series of images was obtained from which the clearance of the free radical through the liver and kidneys could be observed. (author)

Fractional Delayer Utilizing Hermite Interpolation with Caratheodory Representation

Directory of Open Access Journals (Sweden)

Qiang DU

2018-04-01

Full Text Available Fractional delay is indispensable for many sorts of circuits and signal processing applications. Fractional delay filter (FDF utilizing Hermite interpolation with an analog differentiator is a straightforward way to delay discrete signals. This method has a low time-domain error, but a complicated sampling module than the Shannon sampling scheme. A simplified scheme, which is based on Shannon sampling and utilizing Hermite interpolation with a digital differentiator, will lead a much higher time-domain error when the signal frequency approaches the Nyquist rate. In this letter, we propose a novel fractional delayer utilizing Hermite interpolation with Caratheodory representation. The samples of differential signal are obtained by Caratheodory representation from the samples of the original signal only. So, only one sampler is needed and the sampling module is simple. Simulation results for four types of signals demonstrate that the proposed method has significantly higher interpolation accuracy than Hermite interpolation with digital differentiator.

Report of the workshop Energy Utility and Solar Water Heater 1993

International Nuclear Information System (INIS)

1993-01-01

The title workshop was organized to increase the interest of energy utilities for the Solar Water Heater campaign by providing representatives of the utilities with information about the technical and marketing aspects of solar boilers, and to stimulate knowledge transfer between the energy utilities about the method, the possibilities and bottlenecks of solar water heater projects

Vesical endometriosis: utility of imaging techniques

International Nuclear Information System (INIS)

Parra, M.; Cascon, E.; Robledo, R.; Perez, M.

1999-01-01

We present three cases of vesical endometriosis initially studied with ultrasound. One case was also studied with intravenous urography, computed tomography and magnetic resonance imaging. We discuss on the utility of these imaging methods in the diagnosis of vesical endometriosis. (Author) 9 refs

Quantification of superoxide radical production in thylakoid membrane using cyclic hydroxylamines.

Science.gov (United States)

Kozuleva, Marina; Klenina, Irina; Mysin, Ivan; Kirilyuk, Igor; Opanasenko, Vera; Proskuryakov, Ivan; Ivanov, Boris

2015-12-01

Applicability of two lipophilic cyclic hydroxylamines (CHAs), CM-H and TMT-H, and two hydrophilic CHAs, CAT1-H and DCP-H, for detection of superoxide anion radical (O2(∙-)) produced by the thylakoid photosynthetic electron transfer chain (PETC) of higher plants under illumination has been studied. ESR spectrometry was applied for detection of the nitroxide radical originating due to CHAs oxidation by O2(∙-). CHAs and corresponding nitroxide radicals were shown to be involved in side reactions with PETC which could cause miscalculation of O2(∙-) production rate. Lipophilic CM-H was oxidized by PETC components, reducing the oxidized donor of Photosystem I, P700(+), while at the same concentration another lipophilic CHA, TMT-H, did not reduce P700(+). The nitroxide radical was able to accept electrons from components of the photosynthetic chain. Electrostatic interaction of stable cation CAT1-H with the membrane surface was suggested. Water-soluble superoxide dismutase (SOD) was added in order to suppress the reaction of CHA with O2(∙-) outside the membrane. SOD almost completely inhibited light-induced accumulation of DCP(∙), nitroxide radical derivative of hydrophilic DCP-H, in contrast to TMT(∙) accumulation. Based on the results showing that change in the thylakoid lumen pH and volume had minor effect on TMT(∙) accumulation, the reaction of TMT-H with O2(∙-) in the lumen was excluded. Addition of TMT-H to thylakoid suspension in the presence of SOD resulted in the increase in light-induced O2 uptake rate, that argued in favor of TMT-H ability to detect O2(∙-) produced within the membrane core. Thus, hydrophilic DCP-H and lipophilic TMT-H were shown to be usable for detection of O2(∙-) produced outside and within thylakoid membranes. Copyright © 2015 Elsevier Inc. All rights reserved.

The cost-utility of haemodiafiltration versus haemodialysis in the Convective Transport Study

NARCIS (Netherlands)

Mazairac, A.H.; Blankestijn, P.J.; Grooteman, M.P.C.; Penne, E.L.; Weerd, N.C. van der; Hoedt, C.H. den; Buskens, E.; Dorpel, M.A. van den; Wee, P.M. ter; Nube, M.J.; Bots, M.L.; Wit, G.A. de; Hamersvelt, H.W. van; et al.,

2013-01-01

BACKGROUND: Despite the growing interest in haemodiafiltration (HDF), there is no information on the costs and cost-utility of this dialysis modality yet. It was therefore our objective to study the cost-utility of HDF versus haemodialysis (HD). METHODS: A cost-utility analysis was performed using a

The cost-utility of haemodiafiltration versus haemodialysis in the Convective Transport Study

NARCIS (Netherlands)

Mazairac, Albert H. A.; Blankestijn, Peter J.; Grooteman, Muriel P. C.; Penne, E. Lars; van der Weerd, Neelke C.; den Hoedt, Claire H.; Buskens, Erik; van den Dorpel, Marinus A.; ter Wee, Piet M.; Nube, Menso J.; Bots, Michiel L.; de Wit, G. Ardine

Background. Despite the growing interest in haemodiafiltration (HDF), there is no information on the costs and cost-utility of this dialysis modality yet. It was therefore our objective to study the cost-utility of HDF versus haemodialysis (HD). Methods. A cost-utility analysis was performed using a

Combinatorial discovery of enzymes with utility in biomass transformation

Science.gov (United States)

Fox, Brian G; Elsen, Nathaniel L

2015-02-03

Methods for the cell-free identification of polypeptide and polypeptide combinations with utility in biomass transformation, as well as specific novel polypeptides and cell-free systems containing polypeptide combinations discovered by such methods are disclosed.

Utilization of Facebook in studio Arven's marketing

OpenAIRE

Hausmannová, Klára

2012-01-01

Title: Utilization of Facebook in studio Arven's marketing Objectives: The aim of this work is to create a facebook fan page for Power Plate studio Arven in Čelákovice. The facebook fan page was created on the basis of survey. Then the effectiveness of the page was evaluated. Methods: In this work have been taken both quantitative and qualitative methods. The quantitative method was applied in survey among existing clients of studio Arven and facebook fans of fitness clubs. Qualitative method...

Metabolic Engineering for Substrate Co-utilization

Science.gov (United States)

Gawand, Pratish

mutant LMSE2, the mutant is subjected to targeted and whole genome sequencing. Finally, we use the mutant LMSE2 to produce D-ribose from a mixture of glucose and xylose by overexpressing an endogenous phosphatase. The methods developed in this thesis are anticipated to provide a novel approach to solve sugar co-utilization problem in industrial microorganisms, and provide insights into microbial response to forced co-utilization of sugars.

A preliminary approach to creating an overview of lactoferrin multi-functionality utilizing a text mining method.

Science.gov (United States)

Shimazaki, Kei-ichi; Kushida, Tatsuya

2010-06-01

Lactoferrin is a multi-functional metal-binding glycoprotein that exhibits many biological functions of interest to many researchers from the fields of clinical medicine, dentistry, pharmacology, veterinary medicine, nutrition and milk science. To date, a number of academic reports concerning the biological activities of lactoferrin have been published and are easily accessible through public data repositories. However, as the literature is expanding daily, this presents challenges in understanding the larger picture of lactoferrin function and mechanisms. In order to overcome the "analysis paralysis" associated with lactoferrin information, we attempted to apply a text mining method to the accumulated lactoferrin literature. To this end, we used the information extraction system GENPAC (provided by Nalapro Technologies Inc., Tokyo). This information extraction system uses natural language processing and text mining technology. This system analyzes the sentences and titles from abstracts stored in the PubMed database, and can automatically extract binary relations that consist of interactions between genes/proteins, chemicals and diseases/functions. We expect that such information visualization analysis will be useful in determining novel relationships among a multitude of lactoferrin functions and mechanisms. We have demonstrated the utilization of this method to find pathways of lactoferrin participation in neovascularization, Helicobacter pylori attack on gastric mucosa, atopic dermatitis and lipid metabolism.

Explaining Distortions in Utility Elicitation through the Rank-Dependent Model for Risky Choices

NARCIS (Netherlands)

P.P. Wakker (Peter); A.M. Stiggelbout (Anne)

1995-01-01

textabstractThe standard gamble (SG) method has been accepted as the gold standard for the elicitation of utility when risk or uncertainty is involved in decisions, and thus for the measurement of utility in medical decisions. Unfortunately, the SG method is distorted by a general dislike for

Siting guidelines for utility application of wind turbines. Final report

Energy Technology Data Exchange (ETDEWEB)

Pennell, W.T.

1983-01-01

Utility-oriented guidelines are described for identifying viable sites for wind turbines. Topics and procedures are also discussed that are important in carrying out a wind turbine siting program. These topics include: a description of the Department of Energy wind resource atlases; procedures for predicting wind turbine performance at potential sites; methods for analyzing wind turbine economics; procedures for estimating installation and maintenance costs; methods for anlayzing the distribution of wind resources over an area; and instrumentation for documenting wind behavior at potential sites. The procedure described is applicable to small and large utilities. Although the procedure was developed as a site-selection tool, it can also be used by a utility who wishes to estimate the potential for wind turbine penetration into its future generation mix.

Learning a decision maker's utility function from (possibly) inconsistent behavior

DEFF Research Database (Denmark)

Nielsen, Thomas Dyhre; Jensen, Finn Verner

2004-01-01

developed for learning the probabilities from a database.However, methods for learning the utilities have only received limitedattention in the computer science community. A promising approach for learning a decision maker's utility function is to takeoutset in the decision maker's observed behavioral...... patterns, and then find autility function which (together with a domain model) can explainthis behavior. That is, it is assumed that decision maker's preferences arereflected in the behavior. Standard learning algorithmsalso assume that the decision maker is behavioralconsistent, i.e., given a model ofthe...... decision problem, there exists a utility function which canaccount for all the observed behavior. Unfortunately, this assumption israrely valid in real-world decision problems, and in these situationsexisting learning methods may only identify a trivial utilityfunction. In this paper we relax...

Estimating potential stranded commitments for U.S. investor-owned electric utilities

International Nuclear Information System (INIS)

Baxter, L.; Hirst, E.

1995-01-01

New technologies, low natural gas prices, and federal and state utility regions are restructuring the electricity industry. Yesterday's vertically integrated utility with a retail monopoly franchise may be a very different organization in a few years. Conferences, regulatory-commission hearings, and other industry fora are dominated by debates over the extent and form of utility deintegration, wholesale competition, and retail wheeling. A key obstacle to restructuring the electricity industry is stranded commitments. Past investments, power-purchase contracts, and public-policy-driven programs that made sense in an era of cost-of-service regulation may not be cost-effective in a competitive power market. Regulators, utilities, and other parties face tough decisions concerning the mitigation and allocation of these stranded commitments. The authors developed and applied a simple method to calculate the amount of stranded commitments facing US investor-owned electric utilities. The results obtained with this method depend strongly on a few key assumptions: (1) the fraction of utility sales that is at risk with respect to competition, (2) the market price of electric generation, and (3) the number of years during which the utility would lose money because of differences between its embedded cost of production and the market price

Nitrogen utilization efficiency and nitrogen nutrition of rice crops at MADA using the microplot nitrogen balance method

International Nuclear Information System (INIS)

Ahmad Nazrul Abd Wahid; Abdul Razak Ruslan; Latiffah Norddin; Hazlina Abdullah; Khairuddin Abdul Rahim

2004-01-01

Nitrogen (N) is a very important nutrient for rice crops and is a main component of protein. Nitrogen is essential in the production of plant chlorophyll and involves in vegetative and fruit growth and development processes. Nitrogen is a critical input and exert high cost in rice crop production. Nitrogen fertilizer is not fully utilised by the rice crop; some is lost due the processes of vaporization, hydrolysis, erosion, leaching and used by other plants and microorganisms. Several agronomic practices have been studied and adopted in this country with the purpose of increasing the efficiency nitrogen fertilizer utilization and thus, reducing the output cost for rice crops. The microplot nitrogen balance method is one of the methods used to determine uptake efficiency of nitrogen fertilizers by rice crops. In this research, the microplot of 1 m x 1 m squares in paddy plot were used, to ensure that sequential sampling was done at predetermined areas. Scheduled monthly sampling of soil and rice crops was conducted until the mature stage, harvest and post-harvest period. This MINT-MADA cooperative project contains the elements of information sharing on fertilizer efficiency measurement methods by using the N-15 isotopic tracer technique and the N-balance technique in soil, besides the cooperation on use of infrastructure and facilities, expertise and labour. (Author)

Availability and Utilization of Electronic Information Databases by ...

African Journals Online (AJOL)

The study was undertaken to determine the Availability and Utilization of Electronic Information Database by Staff of the Agricultural Complex, Ahmadu Bello University, Zaria. A survey method was used for the study. Stratified sampling method was used to select 209 respondents to accommodate the different strata of the ...

Decontamination trade study for the Light Duty Utility Arm

International Nuclear Information System (INIS)

Rieck, R.H.

1994-01-01

Various methods were evaluated for decontaminating the Light Duty Utility Arm (LDUA). Physical capabilities of each method were compared with the constraints and requirements for the LDUA Decontamination System. Costs were compared and a referred alternative was chosen

Non-parametric estimation of the individual's utility map

OpenAIRE

Noguchi, Takao; Sanborn, Adam N.; Stewart, Neil

2013-01-01

Models of risky choice have attracted much attention in behavioural economics. Previous research has repeatedly demonstrated that individuals' choices are not well explained by expected utility theory, and a number of alternative models have been examined using carefully selected sets of choice alternatives. The model performance however, can depend on which choice alternatives are being tested. Here we develop a non-parametric method for estimating the utility map over the wide range of choi...

Project- versus Lecture-Based Courses: Assessing the Role of Course Structure on Perceived Utility, Anxiety, Academic Performance, and Satisfaction in the Undergraduate Research Methods Course

Science.gov (United States)

Rubenking, Bridget; Dodd, Melissa

2018-01-01

Previous research suggests that undergraduate research methods students doubt the utility of course content and experience math and research anxiety. Research also suggests involving students in hands-on, applied research activities, although empirical data on the scope and nature of these activities are lacking. This study compared academic…

Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.

Science.gov (United States)

Kovacic, Peter

2005-01-01

Cocaine is one of the principal drugs of abuse. Although impressive advances have been made, unanswered questions remain concerning mechanism of toxicity and addiction. Discussion of action mode usually centers on receptor binding and enzyme inhibition, with limited attention to events at the molecular level. This review provides extensive evidence in support of the hypothesis that oxidative metabolites play important roles comprising oxidative stress (OS), reactive oxygen species (ROS), and electron transfer (ET). The metabolites include norcocaine and norcocaine derivatives: nitroxide radical, N-hydroxy, nitrosonium, plus cocaine iminium and formaldehyde. Observed formation of ROS is rationalized by redox cycling involving several possible ET agents. Three potential ones are present in the form of oxidative metabolites, namely, nitroxide, nitrosonium, and iminium. Most attention has been devoted to the nitroxide-hydroxylamine couple which has been designated by various investigators as the principal source of ROS. The proximate ester substituent is deemed important for intramolecular stabilization of reactive intermediates. Reduction potential of nitroxide is in accord with plausibility of ET in the biological milieu. Toxicity by cocaine, with evidence for participation of OS, is demonstrated for many body components, including liver, central nervous system, cardiovascular system, reproductive system, kidney, mitochondria, urine, and immune system. Other adverse effects associated with ROS comprise teratogenesis and apoptosis. Examples of ROS generated are lipid peroxides and hydroxyl radical. Often observed were depletion of antioxidant defenses, and protection by added antioxidants, such as, thiol, salicylate, and deferoxamine. Considerable evidence supports the contention that oxidative ET metabolites of cocaine are responsible for much of the observed OS. Quite significantly, the pro-oxidant, toxic effects, including generation of superoxide and lipid peroxyl

Waste heat utilization in agriculture

International Nuclear Information System (INIS)

Horacek, P.

1983-01-01

The Proceedings contain 17 papers presented at meetings of the Working Group for Waste Heat Utilization of the Committee of the European Society of Nuclear Methods in Agriculture of which 7 fall under the INIS scope. The working group met in May 1980 in Brno, Czechoslovakia, in October 1981 in Aberdeen, Scotland and in September 1982 in Brno. (Z.M.)

Effect of soil type and application method on nutrients absorption and utilization by grape plants 1-Absorption and utilization of manganese using Mn-54

International Nuclear Information System (INIS)

Mohamed, F.A.; Sharaf, A.N.M.; Khamis, M.A.; Sharaf, M.M.

2000-01-01

This work was conducted to study effect of soil type and application method on absorption, translocation and utilization of Mn by grape plants. One year old rooted cuttings of grape (Cv. Ruby seedless) were transplanted in plastic containers filled with 15 kg of three different soils, i.e. clay loam soil, sandy soil and calcareous soil. Fertilization treatments were as follows: Tap water (control) (T1); soil application of N, P,K and Mg (T2); T2 plus soil application of Fe, Mn and Zn (T4). Also, pot experiment was carried out using Mn SO4 at 5ppm for soil application and at 0.5% for foliar application and Mn-54 was used for labelling both solutions. Manganese contents in different organs of grape plant were significantly increased by the three fertilization treatments as compared to those of control. Moreover, highest Mn level was obtained due to foliar application of micro elements and soil application of macro elements T 4 . followed by soil application of both macro-and micro elements T 3 , soil application of macro elements only T2 and control T1

A structured review of health utility measures and elicitation in advanced/metastatic breast cancer

Directory of Open Access Journals (Sweden)

Hao Y

2016-06-01

Full Text Available Yanni Hao,1 Verena Wolfram,2 Jennifer Cook2 1Novartis Pharmaceuticals, East Hanover, NJ, USA; 2Adelphi Values, Bollington, UK Background: Health utilities are increasingly incorporated in health economic evaluations. Different elicitation methods, direct and indirect, have been established in the past. This study examined the evidence on health utility elicitation previously reported in advanced/metastatic breast cancer and aimed to link these results to requirements of reimbursement bodies. Methods: Searches were conducted using a detailed search strategy across several electronic databases (MEDLINE, EMBASE, Cochrane Library, and EconLit databases, online sources (Cost-effectiveness Analysis Registry and the Health Economics Research Center, and web sites of health technology assessment (HTA bodies. Publications were selected based on the search strategy and the overall study objectives. Results: A total of 768 publications were identified in the searches, and 26 publications, comprising 18 journal articles and eight submissions to HTA bodies, were included in the evidence review. Most journal articles derived utilities from the European Quality of Life Five-Dimensions questionnaire (EQ-5D. Other utility measures, such as the direct methods standard gamble (SG, time trade-off (TTO, and visual analog scale (VAS, were less frequently used. Several studies described mapping algorithms to generate utilities from disease-specific health-related quality of life (HRQOL instruments such as European Organization for Research and Treatment of Cancer Quality of Life Questionnaire – Core 30 (EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire – Breast Cancer 23 (EORTC QLQ-BR23, Functional Assessment of Cancer Therapy – General questionnaire (FACT-G, and Utility-Based Questionnaire-Cancer (UBQ-C; most used EQ-5D as the reference. Sociodemographic factors that affect health utilities, such as age, sex

Light duty utility arm startup plan

International Nuclear Information System (INIS)

Barnes, G.A.

1998-01-01

This plan details the methods and procedures necessary to ensure a safe transition in the operation of the Light Duty Utility Arm (LDUA) System. The steps identified here outline the work scope and identify responsibilities to complete startup, and turnover of the LDUA to Characterization Project Operations (CPO)

Evaluation of isotope utilizations in consumer products

International Nuclear Information System (INIS)

Sato, Otomaru

1980-01-01

Consumer products are generally divided into three groups, according to the state of radioactive material or radiation used. First, there are those intentionally added with radioactive materials, such as self-luminous paints and ionization type smoke detectors, utilizing the ionization and excitation by radiation. Second, there are those utilizing natural radioactive materials like glaze. Third, there are those materials containing intrinsically natural radioactive materials. In the first group, the safety evaluation of self-luminous watches and clocks and the risk-benefit evaluation of ionization type smoke detectors are described, and the approval standards for the consumer products and the R/B evaluation method are explained. There are variety of consumer products utilizing radiation, by the exposure dose caused by them is extremely insignificant, far lower than that due to natural radiation. (J.P.N.)

Water Utility Lime Sludge Reuse – An Environmental Sorbent ...

Science.gov (United States)

Lime sludge can be used as an environmental sorbent to remove sulfur dioxide (SO2) and acid gases, by the ultra-fine CaCO3 particles, and to sequester mercury and other heavy metals, by the Natural Organic Matter and residual activated carbon. The laboratory experimental set up included a simulated flue gas preparation unit, a lab-scale wet scrubber, and a mercury analyzer system. The influent mercury concentration was based on a range from 22 surveyed power plants. The reactivity of the lime sludge sample for acid neutralization was determined using a method similar to method ASTM C1318-95. Similar experiments were conducted using reagent calcium carbonate and calcium sulfate to obtain baseline data for comparing with the lime sludge test results. The project also evaluated the techno-economic feasibility and sustainable benefits of reusing lime softening sludge. If implemented on a large scale, this transformative approach for recycling waste materials from water treatment utilities at power generation utilities for environmental cleanup can save both water and power utilities millions of dollars. Huge amounts of lime sludge waste, generated from hundreds of water treatment utilities across the U.S., is currently disposed in landfills. This project evaluated a sustainable and economically-attractive approach to the use of lime sludge waste as a valuable resource for power generation utilities.

Prioritizing Roads Safety Based on the Quasi-Induced Exposure Method and Utilization of the Analytical Hierarchy Process

Directory of Open Access Journals (Sweden)

Sajad rezaei

2014-06-01

Full Text Available Safety analysis of the roads through the accident rates which is one of the widely used tools has been resulted from the direct exposure method which is based on the ratio of the vehicle-kilometers traveled and vehicle-travel time. However, due to some fundamental flaws in its theories and difficulties in gaining access to the data required such as traffic volume, distance and duration of the trip, and various problems in determining the exposure in a specific time, place, and individual categories, there is a need for an algorithm for prioritizing the road safety so that with a new exposure method, the problems of the previous approaches would be resolved. In this way, an efficient application may lead to have more realistic comparisons and the new method would be applicable to a wider range of time, place, and individual categories. Therefore, an algorithm was introduced to prioritize the safety of roads using the quasi-induced exposure method and utilizing the analytical hierarchy process. For this research, 11 provinces of Iran were chosen as case study locations. A rural accidents database was created for these provinces, the validity of quasi-induced exposure method for Iran’s accidents database was explored, and the involvement ratio for different characteristics of the drivers and the vehicles was measured. Results showed that the quasi-induced exposure method was valid in determining the real exposure in the provinces under study. Results also showed a significant difference in the prioritization based on the new and traditional approaches. This difference mostly would stem from the perspective of the quasi-induced exposure method in determining the exposure, opinion of experts, and the quantity of accidents data. Overall, the results for this research showed that prioritization based on the new approach is more comprehensive and reliable compared to the prioritization in the traditional approach which is dependent on various

Dishonest Academic Conduct: From the Perspective of the Utility Function.

Science.gov (United States)

Sun, Ying; Tian, Rui

Dishonest academic conduct has aroused extensive attention in academic circles. To explore how scholars make decisions according to the principle of maximal utility, the author has constructed the general utility function based on the expected utility theory. The concrete utility functions of different types of scholars were deduced. They are as follows: risk neutral, risk averse, and risk preference. Following this, the assignment method was adopted to analyze and compare the scholars' utilities of academic conduct. It was concluded that changing the values of risk costs, internal condemnation costs, academic benefits, and the subjective estimation of penalties following dishonest academic conduct can lead to changes in the utility of academic dishonesty. The results of the current study suggest that within scientific research, measures to prevent and govern dishonest academic conduct should be formulated according to the various effects of the above four variables.

Antitrust concerns in the modern public utility environment

International Nuclear Information System (INIS)

Meeks, J.E.

1996-04-01

Direct regulation of public utility activity and behavior has been the predominant approach to protect the public interest in this country. Changes in technology, as well as new thinking about the optimum role of regulation, have created a changing atmosphere in all of the traditional public utility industries. Competitive markets for many of the products and services in these industries have been developing. While monopoly power will continue to exist in certain parts of these industries and require direct regulation, in many areas a growing reliance upon competition as the best method of serving the public interest is developing. With this shift in emphasis from regulation to free markets, the antitrust laws take on new importance for these industries. In the absence of direct regulator control, those laws are society's primary method of insuring the markets necessary to make competition an effective device for protecting the public interest. This study provides an overview of the antitrust laws, briefly describes the applicable theoretical underpinnings, and then turns to areas where public utility activity may pose special problems or conflicts with prevailing antitrust policy

Antitrust concerns in the modern public utility environment

Energy Technology Data Exchange (ETDEWEB)

Meeks, J.E. [Ohio State Univ., Columbus, OH (United States). Coll. of Law

1996-04-01

Direct regulation of public utility activity and behavior has been the predominant approach to protect the public interest in this country. Changes in technology, as well as new thinking about the optimum role of regulation, have created a changing atmosphere in all of the traditional public utility industries. Competitive markets for many of the products and services in these industries have been developing. While monopoly power will continue to exist in certain parts of these industries and require direct regulation, in many areas a growing reliance upon competition as the best method of serving the public interest is developing. With this shift in emphasis from regulation to free markets, the antitrust laws take on new importance for these industries. In the absence of direct regulator control, those laws are society`s primary method of insuring the markets necessary to make competition an effective device for protecting the public interest. This study provides an overview of the antitrust laws, briefly describes the applicable theoretical underpinnings, and then turns to areas where public utility activity may pose special problems or conflicts with prevailing antitrust policy.

Method and apparstus for determining random coincidence count rate in a scintillation counter utilizing the coincidence technique

International Nuclear Information System (INIS)

Horrocks, D.L.

1980-01-01

A method and apparatus for the reliable determination of a random coincidence count attributable to chance coincidences of single-photon events which are each detected in only a single detector of a scintillation counter utilizing two detectors in a coincidence counting technique are described. A firstdelay device is employed to delay output pulses from one detector, and then the delayed signal is compared with the undelayed signal from the other detector in a coincidence circuit, to obtain an approximate random coincidence count. The output of the coincidence circuit is applied to an anti-coincidence circuit, where it is corrected by elimination of pulses coincident with, and attributable to, conventionally detected real coincidences, and by elimination of pulses coincident with, and attributable to, real coincidences that have been delayed by a second delay device having the same time parameter as the first. 8 claims

Cost of energy from utility-owned solar electric systems. A required revenue method for ERDA/EPRI evaluations

Energy Technology Data Exchange (ETDEWEB)

1976-06-01

This methodology calculates the electric energy busbar cost from a utility-owned solar electric system. This approach is applicable to both publicly- and privately-owned utilities. Busbar cost represents the minimum price per unit of energy consistent with producing system-resultant revenues equal to the sum of system-resultant costs. This equality is expressed in present value terms, where the discount rate used reflects the rate of return required on invested capital. Major input variables describe the output capabilities and capital cost of the energy system, the cash flows required for system operation and maintenance, and the financial structure and tax environment of the utility.

High-utilizing Crohn's disease patients under psychosomatic therapy*

Directory of Open Access Journals (Sweden)

Jantschek Günther

2008-10-01

Full Text Available Abstract Objective Few studies have been published on health care utilization in Crohn's disease and the influence of psychological treatment on high utilizers. Methods The present sub study of a prospective multi center investigation conducted in 87 of 488 consecutive Crohn's disease (CD patients was designed to investigate the influence of the course of Crohn's disease on health care utilization (hospital days (HD and sick leave days (SLD collected by German insurance companies and to examine the conditions of high-utilizing patients. Predictors of health care utilization should be selected. Based on a standardized somatic treatment, high health care utilizing patients of the psychotherapy and control groups should be compared before and after a one-year treatment. Results Multivariate regression analysis identified disease activity at randomization as an important predictor of the clinical course (r2 = 0.28, p 2 = 0.15, p = 0.09. The patients' level of anxiety, depression and lack of control at randomization predicted their health-related quality of life at the end of the study (r2 = 0.51, p 2 = 0.22, p Among high utilizers, a significantly greater drop in HD (p Conclusion The course of Crohn's disease is influenced by psychological as well as somatic factors; especially depression seems important here. A significant drop of health care utilization demonstrates the benefit of psychological treatment in the subgroup of high-utilizing CD patients. Further studies are needed to replicate the findings of the clinical outcome in this CD subgroup.

Methods and energy storage devices utilizing electrolytes having surface-smoothing additives

Science.gov (United States)

Xu, Wu; Zhang, Jiguang; Graff, Gordon L; Chen, Xilin; Ding, Fei

2015-11-12

Electrodeposition and energy storage devices utilizing an electrolyte having a surface-smoothing additive can result in self-healing, instead of self-amplification, of initial protuberant tips that give rise to roughness and/or dendrite formation on the substrate and anode surface. For electrodeposition of a first metal (M1) on a substrate or anode from one or more cations of M1 in an electrolyte solution, the electrolyte solution is characterized by a surface-smoothing additive containing cations of a second metal (M2), wherein cations of M2 have an effective electrochemical reduction potential in the solution lower than that of the cations of M1.

Iranian nurses' constraint for research utilization

Directory of Open Access Journals (Sweden)

Mehrdad Neda

2009-09-01

Full Text Available Abstract Background This paper identifies the views of Iranian clinical nurses regarding the utilization of nursing research in practice. There is a need to understand what restricts Iranian clinical nurses to use research findings. The aim of this study was to identify practicing nurses' view of aspects which they perceived constrain them from research utilization that summarizes and uses research findings to address a nursing practice problem. Methods Data were collected during 6 months by means of face-to face interviews follow by one focus group. Analysis was undertaken using a qualitative content analysis. Results Findings disclosed some key themes perceived by nurses to restrict them to use research findings: level of support require to be research active, to be research minded, the extent of nurses knowledge and skills about research and research utilization, level of educational preparation relating to using research, administration and executive challenges in clinical setting, and theory-practice gap. Conclusion This study identifies constraints that require to be overcome for clinical nurses to actively get involved in research utilization. In this study nurses were generally interested to use research findings. However they felt restricted because of lack of time, lack of peer and manager support and limited knowledge and skills of the research process. This study also confirms that research utilization and the change to research nursing practice are complex issues which require both organizational and educational efforts.

A computationally efficient P_1 radiation model for modern combustion systems utilizing pre-conditioned conjugate gradient methods

International Nuclear Information System (INIS)

Krishnamoorthy, Gautham

2017-01-01

Highlights: • The P_1 radiation model was interfaced with high performance linear solvers. • Pre-conditioned conjugate gradient (PC CG) method improved convergence by 50% • PC CG was more than 30 times faster than classical iterative methods. • The time to solution scaled linearly with increase in problem size employing PC CG. • Employing WSGGM with P_1 model compared reasonably well against benchmark data. - Abstract: The iterative convergence of the P_1 radiation model can be slow in optically thin scenarios when employing classical iterative methods. In order to remedy this shortcoming, an in-house P_1 radiation model was interfaced with high performance, scalable, linear solver libraries. Next, the accuracies of P_1 radiation model calculations was assessed by comparing its predictions against discrete ordinates (DO) model calculations for prototypical problems representative of modern combustion systems. Corresponding benchmark results were also included for comparison. Utilizing Pre-Conditioners (PC) to the Conjugate Gradients (CG) method, the convergence time of the P_1 radiation model reduced by a factor of 30 for modest problem sizes and a factor of 70 for larger sized problems when compared against classical Gauss Seidel sweeps. Further, PC provided 50% computational savings compared to employing CG in a standalone mode. The P_1 model calculation times were about 25–30% of the DO model calculation time. The time to solution also scaled linearly with an increase in problem size. The weighted sum of gray gases model employed in this study in conjunction with the P_1 model provided good agreement against benchmark data with L_2 error norms (defined relative to corresponding DO calculations) improving when isotropic intensities were prevalent.

Development of technologies for utilizing geothermal energy

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

In verifying the effectiveness of the deep geothermal resource exploration technology, development is being carried out on a fracture-type reservoir exploration method. The seismic exploration method investigates detailed structures of underground fracture systems by using seismic waves generated on the ground surface. Verification experiments for fiscal 1994 were carried out by selecting the Kakkonda area in which small fracture networks form reservoir beds. Geothermal resources in deep sections (deeper than 2000 m with temperatures higher than 350{degree}C) are promising in terms of amount of the resources, but anticipated with difficulty in exploration and impediments in drilling. To avoid these risks, studies are being progressed on the availability of resources in deep sections, their utilization possibility, and technologies of effective exploration and drilling. This paper summarizes the results of deep resource investigations during fiscal 1994. It also describes such technological development as hot water utilizing power generation. Development is performed on a binary cycle power generation plant which pumps and utilizes hot water of 150 to 200{degree}C by using a downhole pump. The paper also reports development on element technologies for hot rock power generation systems. It also dwells on development of safe and effective drilling and production technologies for deep geothermal resources.

Patient satisfaction of tooth supported overdentures utilizing ball attachments

OpenAIRE

Nassar, Hossam I.

2016-01-01

Statement of problem: Teeth retained overdenture therapy is an alternative treatment rarely used in cases with few remaining teeth. Purpose: The aim of this study was to evaluate the patient satisfaction associated with teeth retained maxillary and mandibular overdentures utilizing ready made ball attachment. Materials and methods: Thirty patients treated with teeth retained overdenture utilizing ready made ball attachment. Participants completed a series of questionnaires (OHIP-14 ques...

Current radioactive waste utilization at PA 'MAYAK'

International Nuclear Information System (INIS)

Merkushkin, A.O.

2001-01-01

The Production Association 'Mayak' is one of the largest production union of Nuclear Fuel Cycle (NFC) in Russia. In 1988 the last military reactor, which worked for making military plutonium was stopped. From this time civic history of 'Mayak' was began. Today 'Mayak' is the complex production union of NFC, which utilizes the Radiated Nuclear Fuel (RNF). The combine is dynamically develops, new technologies are domesticate and intrude, large works for liquidation of accidents and mistakes of lapsed years are in progress. The short review of radioactive waste utilization methods is present in this account. (author)

Current radioactive waste utilization at PA 'MAYAK'

Energy Technology Data Exchange (ETDEWEB)

Merkushkin, A O [Ozyorsk Technological Institute of Moscow Physical Engineering Institute (Russian Federation)

2001-07-01

The Production Association 'Mayak' is one of the largest production union of Nuclear Fuel Cycle (NFC) in Russia. In 1988 the last military reactor, which worked for making military plutonium was stopped. From this time civic history of 'Mayak' was began. Today 'Mayak' is the complex production union of NFC, which utilizes the Radiated Nuclear Fuel (RNF). The combine is dynamically develops, new technologies are domesticate and intrude, large works for liquidation of accidents and mistakes of lapsed years are in progress. The short review of radioactive waste utilization methods is present in this account. (author)

Overview of Steel Slag Application and Utilization

Directory of Open Access Journals (Sweden)

Lim J.W.

2016-01-01

Full Text Available Significant quantities of steel slag are generated as waste material or byproduct every day from steel industries. Slag is produced from different types of furnaces with different operating conditions. Slag contains Ferrous Oxide, Calcium Oxide, Silica etc. Physical and chemical properties of slag are affected by different methods of slag solidification such as air cooled, steam, and injection of additives. Several material characterization methods, such as X-ray Diffraction (XRD, Scanned Electron Microscopy (SEM and Inductive Coupled Plasma (ICP-OES are used to determine elemental composition in the steel slag. Therefore, slags can become one of the promising materials in various applications such as in transportation industry, construction, cement production, waste water and water treatment. The various applications of steel slag indicate that it can be reused and utilized rather than being disposed to the landfill. This paper presents a review of its applications and utilization.

High utility-itemset mining and privacy-preserving utility mining

Directory of Open Access Journals (Sweden)

Jerry Chun-Wei Lin

2016-03-01

Full Text Available In recent decades, high-utility itemset mining (HUIM has emerging a critical research topic since the quantity and profit factors are both concerned to mine the high-utility itemsets (HUIs. Generally, data mining is commonly used to discover interesting and useful knowledge from massive data. It may, however, lead to privacy threats if private or secure information (e.g., HUIs are published in the public place or misused. In this paper, we focus on the issues of HUIM and privacy-preserving utility mining (PPUM, and present two evolutionary algorithms to respectively mine HUIs and hide the sensitive high-utility itemsets in PPUM. Extensive experiments showed that the two proposed models for the applications of HUIM and PPUM can not only generate the high quality profitable itemsets according to the user-specified minimum utility threshold, but also enable the capability of privacy preserving for private or secure information (e.g., HUIs in real-word applications.

Development of radiation utilization for economic growth in China

International Nuclear Information System (INIS)

Lu Yanxiao

1994-01-01

The program of radiation utilization in China was initiated with the development of nuclear industry in the late 1950s. From then on, the establishment of relatively comprehensive nuclear industrial system and a fair number of talent technical personnel have laid the foundation for radiation utilization in industry, agriculture, medicine and so on. Radioisotopes and radiation become one of the most effective means for acquiring data and information and changing material properties in modern techniques. They are, in many respects, unique and cannot replaced by other techniques. In recent years the considerable progress in the development, commercialization and large-scale utilization of radioisotopes and radiation has been creating economic and social benefits for Chinese modernization. The applications in agriculture have mainly embodied in mutation breeding of crops and so on through radiation or in combination with other methods to provide excellent mutant varieties. The important applications in medicine are the medical diagnosis with radioimmunoassay (RIA) and radiopharmaceutical imaging, and cancer therapy with radioisotopes and electron beam. Well-established methods have bee offered for routine clinic applications to help to heal the patients and rescue the lives. The industrial applications are of key importance in economic growth in China. In fact, radiation processing and nucleonic control systems (NCS) for industrial utilization are very useful to technological transformation of Chinese traditional industries. The radiation utilization in industries can be emerging as new high-tech industries. A fuller exploitation of radiation utilization is expected to meet the requirements of high growth of national economy and to bridge the gap between China and the developed countries in the world in nuclear application. (author)

Development of radiation utilization for economic growth in China

Energy Technology Data Exchange (ETDEWEB)

Yanxiao, Lu [China Nuclear Information Center, Beijing, BJ (China)

1994-01-01

The program of radiation utilization in China was initiated with the development of nuclear industry in the late 1950s. From then on, the establishment of relatively comprehensive nuclear industrial system and a fair number of talent technical personnel have laid the foundation for radiation utilization in industry, agriculture, medicine and so on. Radioisotopes and radiation become one of the most effective means for acquiring data and information and changing material properties in modern techniques. They are, in many respects, unique and cannot replaced by other techniques. In recent years the considerable progress in the development, commercialization and large-scale utilization of radioisotopes and radiation has been creating economic and social benefits for Chinese modernization. The applications in agriculture have mainly embodied in mutation breeding of crops and so on through radiation or in combination with other methods to provide excellent mutant varieties. The important applications in medicine are the medical diagnosis with radioimmunoassay (RIA) and radiopharmaceutical imaging, and cancer therapy with radioisotopes and electron beam. Well-established methods have bee offered for routine clinic applications to help to heal the patients and rescue the lives. The industrial applications are of key importance in economic growth in China. In fact, radiation processing and nucleonic control systems (NCS) for industrial utilization are very useful to technological transformation of Chinese traditional industries. The radiation utilization in industries can be emerging as new high-tech industries. A fuller exploitation of radiation utilization is expected to meet the requirements of high growth of national economy and to bridge the gap between China and the developed countries in the world in nuclear application. (author).

Analysis and planning of the utilization of nuclear power plants

International Nuclear Information System (INIS)

Skvarka, P.

1985-01-01

The utilization coefficient as one of the characteristics of availability of nuclear power plants and the operation results (like maximum power, block number, and electric energy generation) are investigated by different statistic methods for several nuclear power plants with PWR type reactors and compared with those of WWER 440-type reactors. By means of linear many-parameter regression analysis the utilization coefficient is studied in dependence on block power and time after reactor commissioning. Forecastings of mean utilization coefficients are presented for the power of WWER 1000-type reactors

Case study method and problem-based learning: utilizing the pedagogical model of progressive complexity in nursing education.

Science.gov (United States)

McMahon, Michelle A; Christopher, Kimberly A

2011-08-19

As the complexity of health care delivery continues to increase, educators are challenged to determine educational best practices to prepare BSN students for the ambiguous clinical practice setting. Integrative, active, and student-centered curricular methods are encouraged to foster student ability to use clinical judgment for problem solving and informed clinical decision making. The proposed pedagogical model of progressive complexity in nursing education suggests gradually introducing students to complex and multi-contextual clinical scenarios through the utilization of case studies and problem-based learning activities, with the intention to transition nursing students into autonomous learners and well-prepared practitioners at the culmination of a nursing program. Exemplar curricular activities are suggested to potentiate student development of a transferable problem solving skill set and a flexible knowledge base to better prepare students for practice in future novel clinical experiences, which is a mutual goal for both educators and students.

Pretreatment and utilization of waste incineration bottom ashes

DEFF Research Database (Denmark)

Astrup, Thomas

2007-01-01

Within recent years, researchers and authorities have had increasing focus on leaching properties from waste incineration bottom ashes. Researchers have investigated processes such as those related to carbonation, weathering, metal complexation, and leaching control. Most of these investigations......, however, have had a strong emphasis on lab experiments with little focus on full scale bottom ash upgrading methods. The introduction of regulatory limit values restricting leaching from utilized bottom ashes, has created a need for a better understanding of how lab scale experiences can be utilized...

The instrumentation calibration reduction program (ICRP) at Northeast Utilities

International Nuclear Information System (INIS)

Wyckoff, R.; Blanch, P.

1987-01-01

Northeast Utilities (NU) funded a project to study the feasibility of determining the state of core exit thermocouple (CET) calibration without having to have direct access to the CETs. Although the CETs were the prime focus, other safety related sensors were investigated. This paper describes presumptions and methods employed in the first phase, the feasibility study. Additionally, it describes the cost/benefit analysis which can be used by any utility to determine ICRP payback

Utilization of Indigenous Technical Knowledge (ITK'S) in Arid and Semi-Arid Regions of Eastern Kenya: A Coping Strategy to Shocks of Market Utilization

International Nuclear Information System (INIS)

Ndubi, J

2002-01-01

Most of the farmers in the arid and semi arid are poorly endowed with resources. Market liberalisation and withdrawal of government support (subsidies) in accessing some of the modern technologies has led to decreased use of most of the modern recommended technologies due to their high prices. A a coping strategy most of the resources poor farmers have turned to utilization of the indigenous technology to sustain their agricultural production. The main objective of this paper is to document the indigenous technologies utilized by farmers, explore the possibility of refining/calibrating and up-scaling them and the advantages and disadvantages of utilizing them as identified by the farmers. The method for data collection was by use of interviews the farmers who were stratified in terms of gender and age sets (young, middle aged and old) and data analysed by use of qualitative methods. The results indicate that, most farmers do utilize indigenous technology in crops, livestock pests, diseases, soil and water conservation as cropping strategies to increase input prices due to market liberalization and withdrawal of government subsidies. It was also observed that, there is need for scientists to calibrate the most important practices for improved adoption and up-scaling of the main indigenous technologies within and outside the study areas

RDT&E Laboratory Capacity Utilization and Productivity Measurement Methods for Financial Decision-Making within DON

National Research Council Canada - National Science Library

Haupt, Jeffrey

1998-01-01

.... Industry capacity utilization and productivity measurement techniques and models were evaluated for their potential application to the Naval Air Warfare Center Aircraft Division (NAWCAD) RDT&E organization...

Profit maximization algorithms for utility companies in an oligopolistic energy market with dynamic prices and intelligent users

Directory of Open Access Journals (Sweden)

Tiansong Cui

2016-01-01

Full Text Available Dynamic energy pricing provides a promising solution for the utility companies to incentivize energy users to perform demand side management in order to minimize their electric bills. Moreover, the emerging decentralized smart grid, which is a likely infrastructure scenario for future electrical power networks, allows energy consumers to select their energy provider from among multiple utility companies in any billing period. This paper thus starts by considering an oligopolistic energy market with multiple non-cooperative (competitive utility companies, and addresses the problem of determining dynamic energy prices for every utility company in this market based on a modified Bertrand Competition Model of user behaviors. Two methods of dynamic energy pricing are proposed for a utility company to maximize its total profit. The first method finds the greatest lower bound on the total profit that can be achieved by the utility company, whereas the second method finds the best response of a utility company to dynamic pricing policies that the other companies have adopted in previous billing periods. To exploit the advantages of each method while compensating their shortcomings, an adaptive dynamic pricing policy is proposed based on a machine learning technique, which finds a good balance between invocations of the two aforesaid methods. Experimental results show that the adaptive policy results in consistently high profit for the utility company no matter what policies are employed by the other companies.

Planning manual for utility application of WECS

Energy Technology Data Exchange (ETDEWEB)

Park, G.L. (ed.)

1979-06-01

A two-part approach for evaluating the feasibility of wind electric conversion systems (WECS) for utility application is presented and explained. Assessment of wind energy potential, sites, interconnection, and capital and production costing is included. The first part is a brief preliminary procedure used to determine whether the expense and effort of a detailed investigation is justified. The preliminary procedure requires assumptions which limit its accuracy. If the result indicates that WECS have probable potential for a specific utility application, then a set of modifications to detailed conventional planning procedures is developed. The modifications include discussion of wind velocity estimation and effects of site features on wind velocity, institutional problems, siting, choosing generation cases with WECS, reliability considerations, production costing, and operating problems. Appendices include an annotated bibliography, wind measurement methods, procedure for estimating WECS capacity factor, and a method for generating correlated wind velocity samples for use in production cost programs.

Communications technologies for demand side management, DSM, and European utility communications architecture, EurUCA

Energy Technology Data Exchange (ETDEWEB)

Kaerkkaeinen, S.; Kekkonen, V. [VTT Energy, Espoo (Finland); Rissanen, P. [Tietosavo Oy (Finland)

1996-12-31

In this project the main target is to develop and assess methods for DSM (Demand Side Management) and distribution automation planning from the utility`s point of view. The final goal is to integrate these methods for the strategic planning of electric utilities. In practice the project is divided into four main parts: The development and assessment of DSM/IRP planning methods and cost/benefit analysis as a part of international co-operation (IEA DSM Agreement: Annex IV, European Cost/Benefit analysis of DSM, EUBC, and Finnish SAVE-project started in 1995 in co-operation with SRC International and six electric utilities in Finland); Development of PC-based DSM planning and assessment tools at VTT; Development of a decision support system of distribution network planning including DSM options at Tietosavo Oy and Integration of DSM planning and network planning tools in co-operation with VTT Energy and Tietosavo Oy

Communications technologies for demand side management, DSM, and European utility communications architecture, EurUCA

Energy Technology Data Exchange (ETDEWEB)

Kaerkkaeinen, S; Kekkonen, V [VTT Energy, Espoo (Finland); Rissanen, P [Tietosavo Oy (Finland)

1997-12-31

In this project the main target is to develop and assess methods for DSM (Demand Side Management) and distribution automation planning from the utility`s point of view. The final goal is to integrate these methods for the strategic planning of electric utilities. In practice the project is divided into four main parts: The development and assessment of DSM/IRP planning methods and cost/benefit analysis as a part of international co-operation (IEA DSM Agreement: Annex IV, European Cost/Benefit analysis of DSM, EUBC, and Finnish SAVE-project started in 1995 in co-operation with SRC International and six electric utilities in Finland); Development of PC-based DSM planning and assessment tools at VTT; Development of a decision support system of distribution network planning including DSM options at Tietosavo Oy and Integration of DSM planning and network planning tools in co-operation with VTT Energy and Tietosavo Oy

The development of damage identification methods for buildings with image recognition and machine learning techniques utilizing aerial photographs of the 2016 Kumamoto earthquake

Science.gov (United States)

Shohei, N.; Nakamura, H.; Fujiwara, H.; Naoichi, M.; Hiromitsu, T.

2017-12-01

It is important to get schematic information of the damage situation immediately after the earthquake utilizing photographs shot from an airplane in terms of the investigation and the decision-making for authorities. In case of the 2016 Kumamoto earthquake, we have acquired more than 1,800 orthographic projection photographs adjacent to damaged areas. These photos have taken between April 16th and 19th by airplanes, then we have distinguished damages of all buildings with 4 levels, and organized as approximately 296,000 GIS data corresponding to the fundamental Geospatial data published by Geospatial Information Authority of Japan. These data have organized by effort of hundreds of engineers. However, it is not considered practical for more extensive disasters like the Nankai Trough earthquake by only human powers. So, we have been developing the automatic damage identification method utilizing image recognition and machine learning techniques. First, we have extracted training data of more than 10,000 buildings which have equally damage levels divided in 4 grades. With these training data, we have been raster scanning in each scanning ranges of entire images, then clipping patch images which represents damage levels each. By utilizing these patch images, we have been developing discriminant models by two ways. One is a model using the Support Vector Machine (SVM). First, extract a feature quantity of each patch images. Then, with these vector values, calculate the histogram density as a method of Bag of Visual Words (BoVW), then classify borders with each damage grades by SVM. The other one is a model using the multi-layered Neural Network. First, design a multi-layered Neural Network. Second, input patch images and damage levels based on a visual judgement, and then, optimize learning parameters with error backpropagation method. By use of both discriminant models, we are going to discriminate damage levels in each patches, then create the image that shows

Multiattribute Utility Theory, Intertemporal Utility and Correlation Aversion

DEFF Research Database (Denmark)

Andersen, Steffen; Harrison, Glenn W.; Lau, Morten

2018-01-01

Convenient assumptions about qualitative properties of the intertemporal utility function have generated counterintuitive implications for the relationship between atemporal risk aversion and the intertemporal elasticity of substitution. If the intertemporal utility function is additively separable...... aversion. Our results show that subjects are correlation averse over lotteries with intertemporal income profiles....

Effective utilization and management of research reactors

Energy Technology Data Exchange (ETDEWEB)

Muranaka, R [International Atomic Energy Agency, Vienna (Austria). Div. of Research and Isotopes

1984-06-01

The problem of utilizing a research reactor effectively is closely related to its management and therefore should not be considered separately. Too often, attention has been focused on specific techniques and methods rather than on the overall programme of utilization, with the result that skills and equipment have been acquired without any active continuing programme of applications and services. The seminar reported here provided a forum for reactor managers, users, and operators to discuss their experience. At the invitation of the Government of Malaysia, it was held at the Asia Pacific Development Centre, Kuala Lumpur, from 7 to 11 November 1983. It was attended by about 50 participants from 19 Member States; it is hoped that a report on the seminar, including papers presented, can be published and thus reach a wider audience. Thirty-one lectures and contributions were presented at a total of seven sessions: Research reactor management; Radiation exposure and safety; Research reactor utilization (two sessions); PUSPATI Research Reactor Project Development; Core conversion to low-enriched uranium, and safeguards; Research reactor technology. In addition, a panel discussed the causes and resolutions of the under-utilization of research reactors.

Effective utilization and management of research reactors

International Nuclear Information System (INIS)

Muranaka, R.

1984-01-01

The problem of utilizing a research reactor effectively is closely related to its management and therefore should not be considered separately. Too often, attention has been focused on specific techniques and methods rather than on the overall programme of utilization, with the result that skills and equipment have been acquired without any active continuing programme of applications and services. The seminar reported here provided a forum for reactor managers, users, and operators to discuss their experience. At the invitation of the Government of Malaysia, it was held at the Asia Pacific Development Centre, Kuala Lumpur, from 7 to 11 November 1983. It was attended by about 50 participants from 19 Member States; it is hoped that a report on the seminar, including papers presented, can be published and thus reach a wider audience. Thirty-one lectures and contributions were presented at a total of seven sessions: Research reactor management; Radiation exposure and safety; Research reactor utilization (two sessions); PUSPATI Research Reactor Project Development; Core conversion to low-enriched uranium, and safeguards; Research reactor technology. In addition, a panel discussed the causes and resolutions of the under-utilization of research reactors

A multivariate-utility approach for selection of energy sources

International Nuclear Information System (INIS)

Ahmed, S; Husseiny, A.A.

1978-01-01

A deterministic approach is devised to compare the safety features of various energy sources. The approach is based on multiattribute utility theory. The method is used in evaluating the safety aspects of alternative energy sources used for the production of electrical energy. Four alternative energy sources are chosen which could be considered for the production of electricity to meet the national energy demand. These are nuclear, coal, solar, and geothermal energy. For simplicity, a total electrical system is considered in each case. A computer code is developed to evaluate the overall utility function for each alternative from the utility patterns corresponding to 23 energy attributes, mostly related to safety. The model can accommodate other attributes assuming that these are independent. The technique is kept flexible so that virtually any decision problem with various attributes can be attacked and optimal decisions can be reached. The selected data resulted in preference of geothermal and nuclear energy over other sources, and the method is found viable in making decisions on energy uses based on quantified and subjective attributes. (author)

The predictive validity of prospect theory versus expected utility in health utility measurement.

Science.gov (United States)

Abellan-Perpiñan, Jose Maria; Bleichrodt, Han; Pinto-Prades, Jose Luis

2009-12-01

Most health care evaluations today still assume expected utility even though the descriptive deficiencies of expected utility are well known. Prospect theory is the dominant descriptive alternative for expected utility. This paper tests whether prospect theory leads to better health evaluations than expected utility. The approach is purely descriptive: we explore how simple measurements together with prospect theory and expected utility predict choices and rankings between more complex stimuli. For decisions involving risk prospect theory is significantly more consistent with rankings and choices than expected utility. This conclusion no longer holds when we use prospect theory utilities and expected utilities to predict intertemporal decisions. The latter finding cautions against the common assumption in health economics that health state utilities are transferable across decision contexts. Our results suggest that the standard gamble and algorithms based on, should not be used to value health.

Partograph utilization and associated factors among obstetric care ...

African Journals Online (AJOL)

% of maternal deaths which can be reduced by proper utilization of partograph during labor. Methods: An Institution based cross-sectional study was conducted in June, 2013 on 403 obstetric care providers. A pre-test- ed and structured ...

Utilizing the Design Charrette for Teaching Sustainability

Science.gov (United States)

Walker, Jason B.; Seymour, Michael W.

2008-01-01

Purpose: This paper aims to investigate the design charrette as a method for teaching sustainability. Design/methodology/approach: The paper utilizes a student-based design charrette for the Mississippi Gulf Coast comprising a framework for teaching sustainability. An assessment of the charrette's role in promoting sustainability in higher…

New emissions targeting strategy for site utility of process industries

International Nuclear Information System (INIS)

Manesh, Mohamamd Hasan Khoshgoftar; Amidpour, Majid; Hamedi, Mohammad Hosein; Abadi, Sajad Khamis; Ghalami, Hooman

2013-01-01

A new procedure for environmental targeting of co-generation system is presented. The proposed method is based on the concepts of pinch technology for total site targeting of fuel, power, steam, environmental impacts and total annualized cost with considering emissions taxes. This approach provides a consistent, general procedure for determining mass flow rates and efficiencies of the applied turbines. This algorithm utilizes the relationship of entropy with enthalpy and isentropic efficiency. Also, the life cycle assessment (LCA) as a well-known tool for analyzing environmental impacts on a wide perspective with reference to a product system and the related environmental and economic impacts have been applied. In this regard, a damage-oriented impact analysis method based on Eco-indicator 99 and footprints analysis was considered. In addition, the present work demonstrates the effect of including both sensible and latent heating of steam in the extended Site Utility Grand Composite Curve (ESUGCC). It is shown that including sensible heating allows for better thermal matching between the processes. Furthermore, the other representation YSUGCC as the other form of Site Utility Grand Composite has been proposed. Two case studies were used to illustrate the usefulness of the new environmental targeting method

A structured review of health utility measures and elicitation in advanced/metastatic breast cancer.

Science.gov (United States)

Hao, Yanni; Wolfram, Verena; Cook, Jennifer

2016-01-01

Health utilities are increasingly incorporated in health economic evaluations. Different elicitation methods, direct and indirect, have been established in the past. This study examined the evidence on health utility elicitation previously reported in advanced/metastatic breast cancer and aimed to link these results to requirements of reimbursement bodies. Searches were conducted using a detailed search strategy across several electronic databases (MEDLINE, EMBASE, Cochrane Library, and EconLit databases), online sources (Cost-effectiveness Analysis Registry and the Health Economics Research Center), and web sites of health technology assessment (HTA) bodies. Publications were selected based on the search strategy and the overall study objectives. A total of 768 publications were identified in the searches, and 26 publications, comprising 18 journal articles and eight submissions to HTA bodies, were included in the evidence review. Most journal articles derived utilities from the European Quality of Life Five-Dimensions questionnaire (EQ-5D). Other utility measures, such as the direct methods standard gamble (SG), time trade-off (TTO), and visual analog scale (VAS), were less frequently used. Several studies described mapping algorithms to generate utilities from disease-specific health-related quality of life (HRQOL) instruments such as European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Breast Cancer 23 (EORTC QLQ-BR23), Functional Assessment of Cancer Therapy - General questionnaire (FACT-G), and Utility-Based Questionnaire-Cancer (UBQ-C); most used EQ-5D as the reference. Sociodemographic factors that affect health utilities, such as age, sex, income, and education, as well as disease progression, choice of utility elicitation method, and country settings, were identified within the journal articles. Most

Inequities in utilization of reproductive and maternal health services in Ethiopia.

Science.gov (United States)

Bobo, Firew Tekle; Yesuf, Elias Ali; Woldie, Mirkuzie

2017-06-19

Disparities in health services utilization within and between regional states of countries with diverse socio-cultural and economic conditions such as Ethiopia is a frequent encounter. Understanding and taking measures to address unnecessary and avoidable differences in the use of reproductive and maternal health services is a key concern in Ethiopia. The aim of the study was to examine degree of equity in reproductive and maternal health services utilization in Ethiopia. Data from Ethiopia demographic health survey 2014 was analyzed. We assessed inequities in utilization of modern contraceptive methods, antenatal care, facility based delivery and postnatal checkup. Four standard equity measurement methods were used; equity gaps, rate-ratios, concertation curve and concentration index. Inequities in service utilization were exhibited favoring women in developed regions, urban residents, most educated and the wealthy. Antenatal care by skilled provider was three times higher among women with post-secondary education than mothers with no education. Women in the highest wealth quantile had about 12 times higher skilled birth attendance than those in lowest wealth quantile. The rate of postnatal care use among urban resident was about 6 times that of women in rural area. Use of modern contraceptive methods was more equitably utilized service while, birth at health facility was less equitable across all economic levels, favoring the wealthy. Considerable inequity between and within regions of Ethiopia in the use of maternal health services was demonstrated. Strategically targeting social determinants of health with special emphasis to women education and economic empowerment will substantially contribute for altering the current situation favorably.

Community perceptions and factors influencing utilization of health services in Uganda

Directory of Open Access Journals (Sweden)

Galea Sandro

2009-07-01

Full Text Available Abstract Background Healthcare utilization has particular relevance as a public health and development issue. Unlike material and human capital, there is little empirical evidence on the utility of social resources in overcoming barriers to healthcare utilization in a developing country context. We sought to assess the relevance of social resources in overcoming barriers to healthcare utilization. Study Objective To explore community perceptions among three different wealth categories on factors influencing healthcare utilization in Eastern Uganda. Methods We used a qualitative study design using Focus Group Discussions (FGD to conduct the study. Community meetings were initially held to identify FGD participants in the different wealth categories, ('least poor', 'medium' and 'poorest' using poverty ranking based on ownership of assets and income sources. Nine FGDs from three homogenous wealth categories were conducted. Data from the FGDs was analyzed using content analysis revealing common barriers as well as facilitating factors for healthcare service utilization by wealth categories. The Health Access Livelihood Framework was used to examine and interpret the findings. Results Barriers to healthcare utilization exist for all the wealth categories along three different axes including: the health seeking process; health services delivery; and the ownership of livelihood assets. Income source, transport ownership, and health literacy were reported as centrally useful in overcoming some barriers to healthcare utilization for the 'least poor' and 'poor' wealth categories. The 'poorest' wealth category was keen to utilize free public health services. Conversely, there are perceptions that public health facilities were perceived to offer low quality care with chronic gaps such as shortages of essential supplies. In addition to individual material resources and the availability of free public healthcare services, social resources are perceived as

Estimating Utility

DEFF Research Database (Denmark)

Arndt, Channing; Simler, Kenneth R.

2010-01-01

A fundamental premise of absolute poverty lines is that they represent the same level of utility through time and space. Disturbingly, a series of recent studies in middle- and low-income economies show that even carefully derived poverty lines rarely satisfy this premise. This article proposes a......, with the current approach tending to systematically overestimate (underestimate) poverty in urban (rural) zones.......A fundamental premise of absolute poverty lines is that they represent the same level of utility through time and space. Disturbingly, a series of recent studies in middle- and low-income economies show that even carefully derived poverty lines rarely satisfy this premise. This article proposes...... an information-theoretic approach to estimating cost-of-basic-needs (CBN) poverty lines that are utility consistent. Applications to date illustrate that utility-consistent poverty measurements derived from the proposed approach and those derived from current CBN best practices often differ substantially...

Hospice utilization during the SARS outbreak in Taiwan

Directory of Open Access Journals (Sweden)

Lin Ming-Hwai

2006-08-01

Full Text Available Abstract Background The severe acute respiratory syndrome (SARS epidemic threw the world into turmoil during the first half of 2003. Many subsequent papers have addressed its impact on health service utilization, but few have considered palliative (hospice care. The aim of the present study was to describe changes in hospice inpatient utilization during and after the SARS epidemic in 2003 in Taiwan. Methods The data sources were the complete datasets of inpatient admissions during 2002 and 2003 from the National Health Insurance Research Database. Before-and-after comparisons of daily and monthly utilizations were made. Hospice analyses were limited to those wards that offered inpatient services throughout these two years. The comparisons were extended to total hospital bed utilization and to patients who were still admitted to hospice wards during the peak period of the SARS epidemic. Results Only 15 hospice wards operated throughout the whole of 2002 and 2003. In 2003, hospice utilization began to decrease in the middle of April, reached a minimum on 25 May, and gradually recovered to the level of the previous November. Hospices showed a more marked reduction in utilization than all hospital beds (e.g. -52.5% vs. -19.9% in May 2003 and a slower recovery with a three-month lag. In total, 566 patients were admitted to hospice wards in May/June 2003, in contrast to 818 in May/June 2002. Gender, age and diagnosis distributions did not differ. Conclusion Hospice inpatient utilization in Taiwan was indeed more sensitive to the emerging epidemic than general inpatient utilization. A well-balanced network with seamless continuity of care should be ensured.

Dual completion method

Energy Technology Data Exchange (ETDEWEB)

Mamedov, N Ya; Kadymova, K S; Dzhafarov, Sh T

1963-10-28

One type of dual completion method utilizes a single tubing string. Through the use of the proper tubing equipment, the fluid from the low-productive upper formation is lifted by utilizing the surplus energy of a submerged pump, which handles the production from the lower stratum.

Utilization of Smartphone Literacy In Learning Process

Directory of Open Access Journals (Sweden)

Yenni Yuniati

2017-01-01

Full Text Available The utilization of smartphones is increasingly developing among the students. It causes various modifications of attitude and behavior, that media literacy nowadays becomes highly important. Therefore, media literacy shall become the priority for related parties specifically parents and teachers. In addition to helping to find information and to conduct fast communication, smartphone is also functions in formal learning process among the students.The aim of this research is to acknowledge the utilization of smartphones in formal learning process. This study uses qualitative descriptive method which makes serious efforts in describing and depicting utilization of smartphones in learning process among Junior High School students in Bandung. The research result shows that smartphones may function as a device to channel messages and to stimulate the mind, feeling and desire of the students which may encourage learning process in them and to give positive values and to bridge media literacy among the students.

Hesitant Fuzzy Linguistic Preference Utility Set and Its Application in Selection of Fire Rescue Plans

Science.gov (United States)

Si, Guangsen; Xu, Zeshui

2018-01-01

Hesitant fuzzy linguistic term set provides an effective tool to represent uncertain decision information. However, the semantics corresponding to the linguistic terms in it cannot accurately reflect the decision-makers’ subjective cognition. In general, different decision-makers’ sensitivities towards the semantics are different. Such sensitivities can be represented by the cumulative prospect theory value function. Inspired by this, we propose a linguistic scale function to transform the semantics corresponding to linguistic terms into the linguistic preference values. Furthermore, we propose the hesitant fuzzy linguistic preference utility set, based on which, the decision-makers can flexibly express their distinct semantics and obtain the decision results that are consistent with their cognition. For calculations and comparisons over the hesitant fuzzy linguistic preference utility sets, we introduce some distance measures and comparison laws. Afterwards, to apply the hesitant fuzzy linguistic preference utility sets in emergency management, we develop a method to obtain objective weights of attributes and then propose a hesitant fuzzy linguistic preference utility-TOPSIS method to select the best fire rescue plan. Finally, the validity of the proposed method is verified by some comparisons of the method with other two representative methods including the hesitant fuzzy linguistic-TOPSIS method and the hesitant fuzzy linguistic-VIKOR method. PMID:29614019

Individual determinants of research utilization by nurses: a systematic review update

Directory of Open Access Journals (Sweden)

Wallin Lars

2011-01-01

Full Text Available Abstract Background Interventions that have a better than random chance of increasing nurses' use of research are important to the delivery of quality patient care. However, few reports exist of successful research utilization in nursing interventions. Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions. Objective To update the evidence published in a previous systematic review on individual characteristics influencing research utilization by nurses. Methods As part of a larger systematic review on research utilization instruments, 12 online bibliographic databases were searched. Hand searching of specialized journals and an ancestry search was also conducted. Randomized controlled trials, clinical trials, and observational study designs examining the association between individual characteristics and nurses' use of research were eligible for inclusion. Studies were limited to those published in the English, Danish, Swedish, and Norwegian languages. A vote counting approach to data synthesis was taken. Results A total of 42,770 titles were identified, of which 501 were retrieved. Of these 501 articles, 45 satisfied our inclusion criteria. Articles assessed research utilization in general (n = 39 or kinds of research utilization (n = 6 using self-report survey measures. Individual nurse characteristics were classified according to six categories: beliefs and attitudes, involvement in research activities, information seeking, education, professional characteristics, and socio-demographic/socio-economic characteristics. A seventh category, critical thinking, emerged in studies examining kinds of research utilization. Positive relationships, at statistically significant levels, for general research utilization were found in four categories: beliefs and attitudes, information seeking, education, and professional

Individual determinants of research utilization by nurses: a systematic review update

Science.gov (United States)

2011-01-01

Background Interventions that have a better than random chance of increasing nurses' use of research are important to the delivery of quality patient care. However, few reports exist of successful research utilization in nursing interventions. Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions. Objective To update the evidence published in a previous systematic review on individual characteristics influencing research utilization by nurses. Methods As part of a larger systematic review on research utilization instruments, 12 online bibliographic databases were searched. Hand searching of specialized journals and an ancestry search was also conducted. Randomized controlled trials, clinical trials, and observational study designs examining the association between individual characteristics and nurses' use of research were eligible for inclusion. Studies were limited to those published in the English, Danish, Swedish, and Norwegian languages. A vote counting approach to data synthesis was taken. Results A total of 42,770 titles were identified, of which 501 were retrieved. Of these 501 articles, 45 satisfied our inclusion criteria. Articles assessed research utilization in general (n = 39) or kinds of research utilization (n = 6) using self-report survey measures. Individual nurse characteristics were classified according to six categories: beliefs and attitudes, involvement in research activities, information seeking, education, professional characteristics, and socio-demographic/socio-economic characteristics. A seventh category, critical thinking, emerged in studies examining kinds of research utilization. Positive relationships, at statistically significant levels, for general research utilization were found in four categories: beliefs and attitudes, information seeking, education, and professional characteristics. The only

Utility and performance relative to consumer product energy efficiency standards. Final technical report

Energy Technology Data Exchange (ETDEWEB)

Coggins, J.L.

1979-12-14

An investigation of the relative utility and performance of nine major household consumer products covered by the Energy Policy and Conservation Act is summarized. The objective was to define the terms utility and performance, to recommend methods for quantifying these two concepts, and to recommend an approach for dealing with utility and performance issues in the energy efficiency standards program. The definitions developed are: performance of a consumer product is the objective measure of how well, with the expected level of consumer input (following the manufacturer's instructions for installation and operation), the product does its intended job; and utility of a consumer product is a subjective measure, based on the consumer's perception, of the capability of the product to satisfy human needs. Quantification is based on test procedures and consumer survey methods which are largely already in use by industry. Utility and performance issues are important in product classification for prescribing energy efficiency standards. The recommended approach to utility and performance issues and classification is: prior to setting standards, evaluate utility and performance issues in the most quantitative way allowed by resources and schedules in order to develop classification guidelines. This approach requires no changes in existing Department of Energy test procedures.

Ecological balancing of used oil utilization methods. Final report; Oekologische Bilanzierung von Altoel-Verwertungswegen. Oekologischer Vergleich von vier wichtigen Altoelverwertungsverfahren. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Kolshorn, K.U. [ARCADIS Trischler und Partner GmbH (AT und P), Darmstadt (Germany); Fehrenbach, H. [ifeu-Institut fuer Energie- und Umweltforschung GmbH, Heidelberg (Germany)

2000-01-01

In Germany, about 480.000 tons of used oil that are collected each year have to be disposed of and utilized. Four used oil utilization processes (re-processing to base oils; re-processing for fuels; thermal utilization in cement works; pressure gasification for the production of synthesis gas or methanol) were evaluated using an eco-balance. The balance boundary comprises on the one hand the utilization processes and their system-related side-processes (provision of energy, production of auxiliaries, waste disposal, transport) and on the other the processes that are substituted by the products recovered from the utilization processes. The impact assessment covers the indicator list of DIN/NAGUS. Furthermore, the accumulation of pollutants in the products is discussed. On the impact assessment level, no clear ranking of options can be derived since each option has its advantages resp. disadvantages in relation to the other. The reduced impacts of the substituted processes are decisive for the ranking of the option. The final ranking of the options is carried out by the Umweltbundesamt (UBA) based on the interpretation logic of the UBA evaluation method for eco-balances. The present study concludes with the processing and preparation of the balance results for such an interpretation (especially the standardization of the results of the impact assessment based on the total impact assessment based on the total impact in Germany). (orig.) [German] In Deutschland sind jaehrlich ca. 480.000 t Altoel, die im Rahmen der gesetzlich geregelten Altoelsammlung anfallen, zu entsorgen und zu verwerten. Vier Verwertungsverfahren fuer Altoel (Aufarbeitung zu Grundoelen; Aufarbeitung zu Brennstoffen; thermische Nutzung in Zementwerken; Druckvergasung zur Herstellung von Synthesegas bzw. Methanol) wurden anhand einer Oekobilanz bewertet. Der Bilanzraum umfasst einerseits die jeweiligen Verwertungsprozesse incl. der systembedingten Nebenprozesse (Energiebereitstellung

Research on the Prediction Model of CPU Utilization Based on ARIMA-BP Neural Network

Directory of Open Access Journals (Sweden)

Wang Jina

2016-01-01

Full Text Available The dynamic deployment technology of the virtual machine is one of the current cloud computing research focuses. The traditional methods mainly work after the degradation of the service performance that usually lag. To solve the problem a new prediction model based on the CPU utilization is constructed in this paper. A reference offered by the new prediction model of the CPU utilization is provided to the VM dynamic deployment process which will speed to finish the deployment process before the degradation of the service performance. By this method it not only ensure the quality of services but also improve the server performance and resource utilization. The new prediction method of the CPU utilization based on the ARIMA-BP neural network mainly include four parts: preprocess the collected data, build the predictive model of ARIMA-BP neural network, modify the nonlinear residuals of the time series by the BP prediction algorithm and obtain the prediction results by analyzing the above data comprehensively.

Research and development of radiation utilization in 1986 at JAERI

International Nuclear Information System (INIS)

1986-01-01

In the peaceful utilization of atomic energy, in addition to the method of utilizing the energy obtained by nuclear fission and nuclear fusion as electric power or heat source, there is the field of utilizing radiation, in which the effect that radiation exerts on substances and the properties of radiation are used for measurement, analysis and others. The fields of utilizing radiation are diverse such as medicine, technology and agriculture, and those directly related to the health and daily life of people are many. Japan Atomic Energy Research Institute has positively advanced the research and development on radiation utilization, which are related to the utilization of irradiation and the production and use of radioisotopes. The former is carried out in Takasaki Radiation Chemistry Research Establishment, and the latter in the Isotope Division, Tokai Research Establishment. Also, the research and development on the radiation-withstanding properties of organic materials and the production techniques for tritium are advanced, and it is expected to begin the highly advanced scientific and technological research using ion beam. The research and development of polymer materials, the techniques of using irradiation, the production and utilization of radioisotopes and others are reported. (Kako, I.)

EERC Center for Biomass Utilization 2005

Energy Technology Data Exchange (ETDEWEB)

Zygarlicke, C J; Schmidt, D D; Olson, E S; Leroux, K M; Wocken, C A; Aulich, T A; WIlliams, K D

2008-07-28

Biomass utilization is one solution to our nation’s addiction to oil and fossil fuels. What is needed now is applied fundamental research that will cause economic technology development for the utilization of the diverse biomass resources in the United States. This Energy & Environmental Research Center (EERC) applied fundamental research project contributes to the development of economical biomass utilization for energy, transportation fuels, and marketable chemicals using biorefinery methods that include thermochemical and fermentation processes. The fundamental and basic applied research supports the broad scientific objectives of the U.S. Department of Energy (DOE) Biomass Program, especially in the area of developing alternative renewable biofuels, sustainable bioenergy, technologies that reduce greenhouse gas emissions, and environmental remediation. Its deliverables include 1) identifying and understanding environmental consequences of energy production from biomass, including the impacts on greenhouse gas production, carbon emission abatement, and utilization of waste biomass residues and 2) developing biology-based solutions that address DOE and national needs related to waste cleanup, hydrogen production from renewable biomass, biological and chemical processes for energy and fuel production, and environmental stewardship. This project serves the public purpose of encouraging good environmental stewardship by developing biomass-refining technologies that can dramatically increase domestic energy production to counter current trends of rising dependence upon petroleum imports. Decreasing the nation’s reliance on foreign oil and energy will enhance national security, the economy of rural communities, and future competitiveness. Although renewable energy has many forms, such as wind and solar, biomass is the only renewable energy source that can be governed through agricultural methods and that has an energy density that can realistically compete with

Shift level analysis of cable yarder availability, utilization, and productive time

Science.gov (United States)

James R. Sherar; Chris B. LeDoux

1989-01-01

Decision makers, loggers, managers, and planners need to understand and have methods for estimating utilization and productive time of cable logging systems. In making an accurate prediction of how much area and volume a machine will log per unit time and the associated cable yarding costs, a reliable estimate of the availability, utilization, and productive time of...

Risk Decision Making Model for Reservoir Floodwater resources Utilization

Science.gov (United States)

Huang, X.

2017-12-01

Floodwater resources utilization(FRU) can alleviate the shortage of water resources, but there are risks. In order to safely and efficiently utilize the floodwater resources, it is necessary to study the risk of reservoir FRU. In this paper, the risk rate of exceeding the design flood water level and the risk rate of exceeding safety discharge are estimated. Based on the principle of the minimum risk and the maximum benefit of FRU, a multi-objective risk decision making model for FRU is constructed. Probability theory and mathematical statistics method is selected to calculate the risk rate; C-D production function method and emergy analysis method is selected to calculate the risk benefit; the risk loss is related to flood inundation area and unit area loss; the multi-objective decision making problem of the model is solved by the constraint method. Taking the Shilianghe reservoir in Jiangsu Province as an example, the optimal equilibrium solution of FRU of the Shilianghe reservoir is found by using the risk decision making model, and the validity and applicability of the model are verified.

The changing utility workforce and the evolution of utility design

Energy Technology Data Exchange (ETDEWEB)

Saunders, A. [Autodesk Inc., (United States); Zeiss, G. [Autodesk Inc., (Canada)

2008-07-01

Electric utilities are experiencing an unprecedented workforce turnover as a wave of retirement approaches. The challenge for the industry is to mitigate the loss of industry knowledge and attract talented new designers and engineers. Utilities need to effectively transfer knowledge from an existing workforce with up to three decades of experience to their new hires who have very different skill levels as well as different expectations regarding design tools compared to their predecessors. Knowledge transfer from the retiring workforce to the new hires can be facilitated with rules-based design software. Easy-to-use design software with built-in validations can accelerate training. By investing in utility design software that incorporates the best elements of design processes from other industries, utilities can attract the new generation of engineers and designers to help utilities define new processes to upgrade existing infrastructure, bring online new distributed and renewable generation facilities, implement smart devices and meters, and improve customer service. 3 refs.

Robust steganographic method utilizing properties of MJPEG compression standard

Directory of Open Access Journals (Sweden)

Jakub Oravec

2015-06-01

Full Text Available This article presents design of steganographic method, which uses video container as cover data. Video track was recorded by webcam and was further encoded by compression standard MJPEG. Proposed method also takes in account effects of lossy compression. The embedding process is realized by switching places of transform coefficients, which are computed by Discrete Cosine Transform. The article contains possibilities, used techniques, advantages and drawbacks of chosen solution. The results are presented at the end of the article.

Present status of research on radiation utilization in 1994 at JAERI. Utilization of irradiation and RI production and utilization

International Nuclear Information System (INIS)

1994-10-01

In Japan Atomic Energy Research Institute, Takasaki Radiation Chemistry Research Establishment is in charge of the utilization of irradiation, and Tokai Research Establishment is in charge of the production and utilization of radioisotopes. As for the utilization of irradiation the development of new polymers, the development of environment preservation technology such as flue gas treatment, and by using various ion beams from four accelerators, the development of the materials used for space environment, nuclear fusion and new functional materials, the research on the radiation application to biotechnology, the development of the production and utilization of new radioisotopes have been carried out. As for the production and utilization of radioisotopes, the development of new products and new utilization techniques, the technology of producing and using a large amount of tritium, and the research on the chemical behavior of tritium have been carried out. The international cooperations have been promoted positively. In this report, the research activities in 1994 are described. (K.I.)

NON-EXPECTED UTILITY THEORIES: WEIGHTED EXPECTED, RANK DEPENDENT, AND CUMULATIVE PROSPECT THEORY UTILITY

OpenAIRE

Tuthill, Jonathan W.; Frechette, Darren L.

2002-01-01

This paper discusses some of the failings of expected utility including the Allais paradox and expected utility's inadequate one dimensional characterization of risk. Three alternatives to expected utility are discussed at length; weighted expected utility, rank dependent utility, and cumulative prospect theory. Each alternative is capable of explaining Allais paradox type problems and permits more sophisticated multi dimensional risk preferences.

Is Dental Utilization Associated with Oral Health Literacy?

Science.gov (United States)

Burgette, J M; Lee, J Y; Baker, A D; Vann, W F

2016-02-01

The objectives of this study were to examine the pattern of association between dental utilization and oral health literacy (OHL). As part of the Carolina Oral Health Literacy Project, clients in the Women, Infants, and Children's Special Supplemental Nutrition Program completed a structured 30-min in-person interview conducted by 2 trained interviewers at 9 sites in 7 counties in North Carolina. Data were collected on clients' OHL, sociodemographics, dental utilization, self-efficacy, and dental knowledge. The outcome, OHL, was measured with a dental word recognition test (30-item Rapid Estimate of Adult Literacy in Dentistry). Descriptive and multiple linear regression methods were used to examine the distribution of OHL and its association with covariates. After adjusting for age, education, race, marital status, self-efficacy, and dental knowledge, multiple linear regression showed that dental utilization was not a significant predictor of OHL (P > 0.05). Under the conditions of this study, dental utilization was not a significant predictor of OHL. © International & American Associations for Dental Research 2015.

Biomarkers derived from heterolytic and homolytic cleavage of allylic hydroperoxides resulting from alkenone autoxidation

Digital Repository Service at National Institute of Oceanography (India)

Rontania, J.F.; Harji, R.; Volkmanc, J.K.

Laboratory incubation of alkenone mixtures with tert-butyl hydroperoxide and di-tert-butyl nitroxide (radical initiator) in hexane, as a means to simulate alkenone autoxidation processes, rapidly led to the formation of allylic hydroperoxides, whose...

Federal Energy Efficiency through Utility Partnerships: Federal Energy Management Program (FEMP) Program Overview Fact Sheet

International Nuclear Information System (INIS)

Beattie, D.; Wolfson, M.

2001-01-01

This Utility Program Overview describes how the Federal Energy Management Program (FEMP) utility program assists Federal energy managers. The document identifies both a utility financing mechanism and FEMP technical assistance available to support agencies' implementation of energy and water efficiency methods and renewable energy projects

Interrupted time series analysis in drug utilization research is increasing: systematic review and recommendations.

Science.gov (United States)

Jandoc, Racquel; Burden, Andrea M; Mamdani, Muhammad; Lévesque, Linda E; Cadarette, Suzanne M

2015-08-01

To describe the use and reporting of interrupted time series methods in drug utilization research. We completed a systematic search of MEDLINE, Web of Science, and reference lists to identify English language articles through to December 2013 that used interrupted time series methods in drug utilization research. We tabulated the number of studies by publication year and summarized methodological detail. We identified 220 eligible empirical applications since 1984. Only 17 (8%) were published before 2000, and 90 (41%) were published since 2010. Segmented regression was the most commonly applied interrupted time series method (67%). Most studies assessed drug policy changes (51%, n = 112); 22% (n = 48) examined the impact of new evidence, 18% (n = 39) examined safety advisories, and 16% (n = 35) examined quality improvement interventions. Autocorrelation was considered in 66% of studies, 31% reported adjusting for seasonality, and 15% accounted for nonstationarity. Use of interrupted time series methods in drug utilization research has increased, particularly in recent years. Despite methodological recommendations, there is large variation in reporting of analytic methods. Developing methodological and reporting standards for interrupted time series analysis is important to improve its application in drug utilization research, and we provide recommendations for consideration. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Impact of power purchases from non-utilities on the utility cost of capital

International Nuclear Information System (INIS)

Kahn, E.; Stoft, S.; Belden, T.

1995-01-01

The bond rating agencies in the USA have asserted that long-term power purchase contracts between non-utility generators and utilities are the equivalent of debt to the utilities, and therefore raise the cost of capital to the purchaser. Non-Utility generators claim that these contracts reduce risk to the utilities. This debate is reflected in the 1992 Energy Policy Act. This paper investigates this controversy from the perspective of the equity markets. Using a CAPM framework, various specifications of the cost of equity capital are estimated, to shed light on this question. No evidence is found for the hypothesis that non-utility generation contracts raise the cost of capital. There does appear to be a slight increase in this cost for those utilities seeking to build their own generation capacity as opposed to purchasing it from non-utility suppliers. (author)

Control Methods Utilizing Energy Optimizing Schemes in Refrigeration Systems

DEFF Research Database (Denmark)

Larsen, L.S; Thybo, C.; Stoustrup, Jakob

2003-01-01

The potential energy savings in refrigeration systems using energy optimal control has been proved to be substantial. This however requires an intelligent control that drives the refrigeration systems towards the energy optimal state. This paper proposes an approach for a control, which drives th...... the condenser pressure towards an optimal state. The objective of this is to present a feasible method that can be used for energy optimizing control. A simulation model of a simple refrigeration system will be used as basis for testing the control method....

Demand-side management pricing options in electric utilities

International Nuclear Information System (INIS)

Sardana, P.; Herman, P.

1990-01-01

In 1989 Ontario Hydro implemented optional time-of-use (TOU) rates at the wholesale level for all municipal utilities in the province. At the same time, mandatory TOU rates were implemented for large users (customers with loads in excess of 5 MW) served by municipal utilities and Ontario Hydro's direct customers. To fully explore the potential of rate structures as demand-side management (DSM) tools, Ontario Hydro retained a consulting firm to carry out a survey of innovative rate structures in other jurisdications. The survey was intended to identify: the status quo of rate structures in other jurisdictions that were designed specifically to encourage DSM; a profile of the cost basis of the rate structures, for example whether traditional embedded cost of service analyses or contentious methods such as marginal cost pricing were used; whether innovative rates have been successful, and customer reactions and attitudes; and how innovative rates fit into the overall strategy of the utilities. It was found that TOU, interruptible and end-use targeted rates are the rate structures of choice for many utilities. Most are concerned with deferring capacity, reducing peak demand, and shifting load out of peak periods. Most utilities report success with their programs and satisfaction with the present form of the programs. 5 tabs

Utility residual fuel oil market conditions: An update

International Nuclear Information System (INIS)

Mueller, H.A. Jr.

1992-01-01

Planning for residual fuel oil usage and management remains an important part of the generation fuel planning and management function for many utilities. EPRI's Utility Planning Methods Center has maintained its analytical overview of the fuel oil markets as part of its overall fuel planning and management research program. This overview provides an update of recent fuel oil market directions. Several key events of the past year have had important implications for residual fuel oil markets. The key events have been the changes brought about by the Persian Gulf War and its aftermath, as well as continuing environmental policy developments. The Persian Gulf conflict has created renewed interest in reducing fuel oil use by utilities as part of an overall reduction in oil imports. The policy analysis performed to date has generally failed to properly evaluate utility industry capability. The Persian Gulf conflict has also resulted in an important change in the structure of international oil markets. The result of this policy-based change is likely to be a shift in oil pricing strategy. Finally, continued change in environmental requirements is continuing to shift utility residual oil requirements, but is also changing the nature of the US resid market itself

Utilization of prostate brachytherapy for low risk prostate cancer: Is the decline overstated?

OpenAIRE

Joseph Safdieh; Andrew Wong; Joseph P. Weiner; David Schwartz; David Schreiber

2016-01-01

Purpose : Several prior studies have suggested that brachytherapy utilization has markedly decreased, coinciding with the recent increased utilization of intensity modulated radiation therapy, as well as an increase in urologist-owned centers. We sought to investigate the brachytherapy utilization in a large, hospital-based registry. Material and methods: Men with prostate cancer diagnosed between 2004-2012 and treated with either external beam radiation and/or prostate brachytherapy ...

Experimental and numerical investigation of the flow measurement method utilized in the steam generator of HTR-PM

Energy Technology Data Exchange (ETDEWEB)

Wang, Shiming; Ren, Cheng; Sun, Yangfei [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China); Tu, Jiyuan [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China); School of Aerospace, Mechanical & Manufacturing Engineering, RMIT University, Melbourne, VIC 3083 (Australia); Yang, Xingtuan, E-mail: yangxt107@sina.com [Institute of Nuclear and New Energy Technology of Tsinghua University, Collaborative Innovation Center of Advanced Nuclear Energy Technology, Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education, Beijing 100084 (China)

2016-08-15

Highlights: • The flow confluence process in the steam generator is very important for HTR-PM. • The complicated flow in the unique pipeline configuration is studied by both of experimental and numerical method. • The pressure uniformity at the bottom of the model was tested to evaluate the accuracy of the experimental results. • Flow separation and the secondary flow is described for explaining the nonuniformity of the flow distribution. - Abstract: The helium flow measurement method is very important for the design of HTR-PM. Water experiments and numerical simulation with a 1/5 scaled model are conducted to investigate the flow measurement method utilized in the steam generator of HTR-PM. Pressure information at specific location of the 90° elbows with the diameter of 46.75 mm and radius ratio of 1.5 is measured to evaluate the flow rate in the riser-pipes. Pressure uniformity at the bottom of the experimental apparatus is tested to evaluate the influence of the equipment error on the final experimental results. Numerical results obtained by using the realizable k–ε model are compared with the experimental data. The results reveal that flow oscillation does not occur in the confluence system. For every single riser-pipe, the flow is stable despite the nonuniformity of the flow distribution. The average flow rates of the two pipe series show good repeatability regardless of the increases and decreases of the average velocity. In the header box, the flows out of the riser-pipes encounter with each other and finally distort the pressure distribution and the nonuniformity of the flow distribution becomes more significant along with the increasing Reynolds number.

Method of configuring a cell of a wireless communication system for improved resource utilization

NARCIS (Netherlands)

2013-01-01

At least one base station of a wireless network adjusts its access area so as to drive at least one measure of utilization of a resource or resources of that cell toward, but not to exceed, a specified maximum level. The adjustment is dynamic in that it responds in real time to traffic fluctuations.

Utilization of protein-rich residues in biotechnological processes.

Science.gov (United States)

Pleissner, Daniel; Venus, Joachim

2016-03-01

A drawback of biotechnological processes, where microorganisms convert biomass constituents, such as starch, cellulose, hemicelluloses, lipids, and proteins, into wanted products, is the economic feasibility. Particularly the cost of nitrogen sources in biotechnological processes can make up a large fraction of total process expenses. To further develop the bioeconomy, it is of considerable interest to substitute cost-intensive by inexpensive nitrogen sources. The aim of this mini-review was to provide a comprehensive insight of utilization methods of protein-rich residues, such as fish waste, green biomass, hairs, and food waste. The methods described include (i) production of enzymes, (ii) recovery of bioactive compounds, and/or (iii) usage as nitrogen source for microorganisms in biotechnological processes. In this aspect, the utilization of protein-rich residues, which are conventionally considered as waste, allows the development of value-adding processes for the production of bioactive compounds, biomolecules, chemicals, and materials.

Utilization of family planning services by married Sudanese women of reproductive age.

Science.gov (United States)

Ibnouf, A H; van den Borne, H W; Maarse, J A M

2007-01-01

To explore differences in utilization of family planning services and predisposing factors, we surveyed 601 women from urban and rural areas of Khartoum state. About half were using modern family planning techniques; there were no significant differences in utilization rates between urban and rural settings. Contraceptive pills were the most frequently used modern method (47.7%) followed by intrauterine devices (10.2%) and injections (7.5%). Breastfeeding was used by around 33% of both groups. The rhythm method and withdrawal were more often used by urban women (22.2% and 8.6% respectively) than rural women (16.1% and 3.6% respectively). Use of male methods (condom; sterilization) was extremely low. Socioeconomic status, knowledge and education level were the most important determinants of using modern methods.

Utility of the physical examination in detecting pulmonary hypertension. A mixed methods study.

Science.gov (United States)

Colman, Rebecca; Whittingham, Heather; Tomlinson, George; Granton, John

2014-01-01

Patients with pulmonary hypertension (PH) often present with a variety of physical findings reflecting a volume or pressure overloaded right ventricle (RV). However, there is no consensus regarding the diagnostic utility of the physical examination in PH. We conducted a systematic review of publications that evaluated the clinical examination and diagnosis of PH using MEDLINE (1946-2013) and EMBASE (1947-2013). We also prospectively evaluated the diagnostic utility of the physical examination findings. Patients who underwent right cardiac catheterization for any reason were recruited. After informed consent, participants were examined by 6 physicians (3 "specialists" and 3 "generalists") who were unaware of the results of the patient's hemodynamics. Each examiner independently assessed patients for the presence of a RV lift, loud P2, jugular venous distension (JVD), tricuspid insufficiency murmur and right-sided 4th heart sound at rest and during a slow inspiration. A global rating (scale of 1-5) of the likelihood that the patient had pulmonary hypertension was provided by each examiner. 31 articles that assessed the physical examination in PH were included in the final analysis. There was heterogeneity amongst the studies and many did not include control data. The sign most associated with PH in the literature was a loud pulmonic component of the second heart sound (P2). In our prospective study physical examination was performed on 52 subjects (25 met criteria for PH; mPAP ≥ 25 mmHg). The physical sign with the highest likelihood ratio (LR) was a loud P2 on inspiration with a LR +ve 1.9, 95% CrI [1.2, 3.1] when data from all examiners was analyzed together. Results from the specialist examiners had higher diagnostic utility; a loud P2 on inspiration was associated with a positive LR of 3.2, 95% CrI [1.5, 6.2] and a right sided S4 on inspiration had a LR +ve 4.7, 95% CI [1.0, 15.6]. No aspect of the physical exam, could consistently rule out PH (negative LRs 0

The impact of ageing and changing utilization patterns on future cardiovascular drug expenditure: a pharmacoepidemiological projection approach

DEFF Research Database (Denmark)

Kildemoes, Helle Wallach; Andersen, Morten; Støvring, Henrik

2010-01-01

To develop a method for projecting the impact of ageing and changing drug utilization patterns on future drug expenditure.......To develop a method for projecting the impact of ageing and changing drug utilization patterns on future drug expenditure....

Estimation of health state utilities in breast cancer

Directory of Open Access Journals (Sweden)

Kim SH

2017-03-01

Full Text Available Seon-Ha Kim,1 Min-Woo Jo,2 Minsu Ock,2 Hyeon-Jeong Lee,2 Jong-Won Lee3,4 1Department of Nursing, College of Nursing, Dankook University, Cheonan, 2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, 3Department of Breast and Endocrine Surgery, Asan Medical Center, Seoul, 4Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea Purpose: The aim of this study is to determine the utility of breast cancer health states using the standard gamble (SG and visual analog scale (VAS methods in the Korean general population.Materials and methods: Eight hypothetical breast cancer health states were developed based on patient education material and previous publications. Data from 509 individuals from the Korean general population were used to evaluate breast cancer health states using the VAS and the SG methods, which were obtained via computer-assisted personal interviews. Mean utility values were calculated for each human papillomavirus (HPV-related health state.Results: The rank of health states was identical between two valuation methods. SG values were higher than VAS values in all health states. The utility values derived from SG were 0.801 (noninvasive breast cancer with mastectomy and followed by reconstruction, 0.790 (noninvasive breast cancer with mastectomy only, 0.779 (noninvasive breast cancer with breast-conserving surgery and radiation therapy, 0.731 (invasive breast cancer with surgery, radiation therapy, and/or chemotherapy, 0.610 (locally advanced breast cancer with radical mastectomy with radiation therapy, 0.587 (inoperable locally advanced breast cancer, 0.496 (loco-regional recurrent breast cancer, and 0.352 (metastatic breast cancer.Conclusion: Our findings might be useful for economic evaluation of breast cancer screening and interventions in general populations. Keywords: breast neoplasm, Korea, quality-adjusted life years, quality of life

Clinical Utility of Noninvasive Method to Measure Specific Gravity in the Pediatric Population.

Science.gov (United States)

Hall, Jeanine E; Huynh, Pauline P; Mody, Ameer P; Wang, Vincent J

2018-04-01

Clinicians rely on any combination of signs and symptoms, clinical scores, or invasive procedures to assess the hydration status in children. Noninvasive tests to evaluate for dehydration in the pediatric population are appealing. The objective of our study is to assess the utility of measuring specific gravity of tears compared to specific gravity of urine and the clinical assessment of dehydration. We conducted a prospective cohort convenience sample study, in a pediatric emergency department at a tertiary care children's hospital. We approached parents/guardians of children aged 6 months to 4 years undergoing transurethral catheterization for evaluation of urinary tract infection for enrollment. We collected tears and urine for measurement of tear specific gravity (TSG) and urine specific gravity (USG), respectively. Treating physicians completed dehydration assessment forms to assess for hydration status. Among the 60 participants included, the mean TSG was 1.0183 (SD = 0.007); the mean USG was 1.0186 (SD = 0.0083). TSG and USG were positively correlated with each other (Pearson Correlation = 0.423, p = 0.001). Clinical dehydration scores ranged from 0 to 3, with 87% assigned a score of 0, by physician assessment. Mean number of episodes of vomiting and diarrhea in a 24-hour period were 2.2 (SD = 3.9) and 1.5 (SD = 3.2), respectively. Sixty-two percent of parents reported decreased oral intake. TSG measurements yielded similar results compared with USG. Further studies are needed to determine if TSG can be used as a noninvasive method of dehydration assessment in children. Copyright © 2017 Elsevier Inc. All rights reserved.

Intrinsic kinetic parameters of substrate utilization by immobilized anaerobic sludge.

Science.gov (United States)

Zaiat, M; Vieira, L G; Foresti, E

1997-01-20

This article presents a method for evaluating the intrinsic kinetic parameters of the specific substrate utilization rate (r) equation and discusses the results obtained for anaerobic sludge-bed samples taken from a horizontal-flow anaerobic immobilized sludge (HAIS) reactor. This method utilizes a differential reactor filled with polyurethane foam matrices containing immobilized anaerobic sludge which is subjected to a range of feeding substrate flow rates. The range of liquid superficial velocities thus obtained are used for generating data of observed specific substrate utilization rates (r(obs)) under a diversity of external mass transfer resistance conditions. The r(obs) curves are then adjusted to permit their extrapolation for the condition of no external mass transfer resistance, and the values determined are used as a test for the condition of absence of limitation of internal mass transfer. The intrinsic parameters r(max), the maximum specific substrate utilization rate, and K(s), the half-velocity coefficient, are evaluated from the r values under no external mass transfer resistance and no internal mass transfer limitation. The application of such a method for anaerobic sludge immobilized in polyurethane foam particles treating a glucose substrate at 30 degrees C resulted in intrinsic r(max) and K(s), respectively, of 0.330 mg chemical oxygen demand (COD) . mg(-1) volatile suspended solids (VSS) . h(-1) and 72 mg COD . L(-1). In comparison with the values found in the literature, intrinsic r(max) is significantly high and intrinsic K(s) is relatively low. (c) 1997 John Wiley & Sons, Inc.

Women’s autonomy and maternal healthcare service utilization in Ethiopia

OpenAIRE

Fentanesh Nibret Tiruneh; Kun-Yang Chuang; Ying-Chih Chuang

2017-01-01

Background Most previous studies on healthcare service utilization in low-income countries have not used a multilevel study design to address the importance of community-level women’s autonomy. We assessed whether women’s autonomy, measured at both individual and community levels, is associated with maternal healthcare service utilization in Ethiopia. Methods We analyzed data from the 2005 and 2011 Ethiopia Demographic and Health Surveys (N = 6058 and 7043, respectively) for measuring women’s...

Gender differences in students' utilization of electronic information ...

African Journals Online (AJOL)

The study determined gender differences among students in the utilization of electronic information resources in Ramat Library, University of Maiduguri. One objective,with corresponding hypotheses guided the study. The survey research method was used. The population for the study comprised 13,995 (thirteen thousand, ...

Japanese utilities' plutonium utilization program

International Nuclear Information System (INIS)

Matsuo, Yuichiro.

1996-01-01

Japan's 10 utility companies are working and will continue to work towards establishing a fully closed nuclear fuel cycle. The key goals of which are: (1) reprocessing spent fuel; (2) recycling recovered uranium and plutonium; and (3) commercializing fast breeder technology by around the year 2030. This course of action by the Japanese electric power industry is in full accordance with Japan's national policy outlined in the government's report ''The Long-Term Program for Research, Development, and Nuclear Energy,'' which was published in June 1994. The Japanese civilian nuclear program is a long-term program that looks into the 21st century and beyond. It is quite true that sustaining the recycling option for energy security and the global environment demands a large investment. For it to be accepted by the public, safety must be the highest priority and will be pursued at a great cost if necessary. In its history, Japan has learned that as technology advances, costs will come down. The Japanese utility industry will continue investment in technology without compromising safety until the recycling option becomes more competitive with other options. This effort will be equally applied to the development of the commercial FBRs. The Japanese utility industry is confident that Japan's stable policy and strong objective to develop competitive and peaceful technology will contribute to the global economy and the environment without increasing the threat of plutonium proliferation

Site Assessment of Multiple-Sensor Approaches for Buried Utility Detection

Directory of Open Access Journals (Sweden)

Alexander C. D. Royal

2011-01-01

Full Text Available The successful operation of buried infrastructure within urban environments is fundamental to the conservation of modern living standards. Open-cut methods are predominantly used, in preference to trenchless technology, to effect a repair, replace or install a new section of the network. This is, in part, due to the inability to determine the position of all utilities below the carriageway, making open-cut methods desirable in terms of dealing with uncertainty since the buried infrastructure is progressively exposed during excavation. However, open-cut methods damage the carriageway and disrupt society's functions. This paper describes the progress of a research project that aims to develop a multi-sensor geophysical platform that can improve the probability of complete detection of the infrastructure buried beneath the carriageway. The multi-sensor platform is being developed in conjunction with a knowledge-based system that aims to provide information on how the properties of the ground might affect the sensing technologies being deployed. The fusion of data sources (sensor data and utilities record data is also being researched to maximize the probability of location. This paper describes the outcome of the initial phase of testing along with the development of the knowledge-based system and the fusing of data to produce utility maps.

A review of health utilities across conditions common in paediatric and adult populations

Directory of Open Access Journals (Sweden)

Hopkins Robert B

2010-01-01

Full Text Available Abstract Background Cost-utility analyses are commonly used in economic evaluations of interventions or conditions that have an impact on health-related quality of life. However, evaluating utilities in children presents several challenges since young children may not have the cognitive ability to complete measurement tasks and thus utility values must be estimated by proxy assessors. Another solution is to use utilities derived from an adult population. To better inform the future conduct of cost-utility analyses in paediatric populations, we reviewed the published literature reporting utilities among children and adults across selected conditions common to paediatric and adult populations. Methods An electronic search of Ovid MEDLINE, EMBASE, and the Cochrane Library up to November 2008 was conducted to identify studies presenting utility values derived from the Health Utilities Index (HUI or EuroQoL-5Dimensions (EQ-5D questionnaires or using time trade off (TTO or standard gamble (SG techniques in children and/or adult populations from randomized controlled trials, comparative or non-comparative observational studies, or cross-sectional studies. The search was targeted to four chronic diseases/conditions common to both children and adults and known to have a negative impact on health-related quality of life (HRQoL. Results After screening 951 citations identified from the literature search, 77 unique studies included in our review evaluated utilities in patients with asthma (n = 25, cancer (n = 23, diabetes mellitus (n = 11, skin diseases (n = 19 or chronic diseases (n = 2, with some studies evaluating multiple conditions. Utility values were estimated using HUI (n = 33, EQ-5D (n = 26, TTO (n = 12, and SG (n = 14, with some studies applying more than one technique to estimate utility values. 21% of studies evaluated utilities in children, of those the majority being in the area of oncology. No utility values for children were reported in skin

Gross domestic product estimation based on electricity utilization by artificial neural network

Science.gov (United States)

Stevanović, Mirjana; Vujičić, Slađana; Gajić, Aleksandar M.

2018-01-01

The main goal of the paper was to estimate gross domestic product (GDP) based on electricity estimation by artificial neural network (ANN). The electricity utilization was analyzed based on different sources like renewable, coal and nuclear sources. The ANN network was trained with two training algorithms namely extreme learning method and back-propagation algorithm in order to produce the best prediction results of the GDP. According to the results it can be concluded that the ANN model with extreme learning method could produce the acceptable prediction of the GDP based on the electricity utilization.

Postacute Stroke Rehabilitation Utilization: Are There Differences between Rural-Urban Patients and Taxonomies?

Science.gov (United States)

Jia, Huanguang; Cowper, Diane C.; Tang, Yuhong; Litt, Eric; Wilson, Lauren

2012-01-01

Purpose: To assess the association between Veterans Affairs (VA) stroke patients' poststroke rehabilitation utilization and their residential settings by using 2 common rural-urban taxonomies. Methods: This retrospective study included all VA stroke inpatients in 2001 and 2002. Rehabilitation utilization referred to rehabilitation therapy received…

factors affecting antenatal care service utilization in yem special ...

African Journals Online (AJOL)

jhon

assess antenatal care utilization and factors that affect it in Yem Special Woreda, South Western Ethiopia. METHODS: A ... A pre-tested structured questionnaire consisting of information on socio- ..... model and access to medical care: does it.

Accelerator science and its civil and utility engineering work

International Nuclear Information System (INIS)

Yoshioka, Masakazu

2006-01-01

In large-scale accelerator projects such as TRISTAN and J-PARC, approximately half of the total project costs are spent on the civil and utility engineering work for the accelerator. In addition, the quality of civil and utility engineering has a large effect on the quality of the beam. With increasing scale of projects, there is growing specialization of the people in charge of the accelerator on the one hand, and the people in charge of civil and utility engineering on the other. Mutual understanding between the people in charge is therefore important in such cases. From the experience I have accumulated working on the facilities of many large projects, I have become keenly aware of the necessity for both accelerator-literate civil engineering specialists and civil engineering-literate accelerator researchers. A straight-forward method for satisfying this requirement is to systematize accelerator science as a science with civil and utility engineering for accelerators recognized as its sub-field. When new projects launched, the methodology of the natural sciences should be incorporated whereby past experience is fully utilized and then new technologies and knowledge are accumulated. (author)

Improving utility conservation programs: outcomes, interventions, and evaluations

Energy Technology Data Exchange (ETDEWEB)

Condelli, L; Archer, D; Aronson, E; Curbow, B; McLeod, B; Pettigrew, T F; White, L T; Yates, S

1984-06-01

Four major California utility companies have active energy conservation programs mandated by the State's Public Utilities Commission (CPUC). These companies evaluate their programs and send reports of the evaluations to the CPUC. A review of 213 of these reports revealed a marketing research approach toward promoting conservation. Advertising and informational campaigns characterize most programs, and attitudes and self-reported behavior were the major outcome measures. This approach is shown to be ineffective. Suggestions for improvement include: (1) the use of actual energy consumption as the primary outcome measure in evaluating conservation programs; (2) the abandonment of conventional advertising, and the use of it only for the promotion of ''hard'' interventions; (3) increased use of social diffusion methods to disseminate information; (4) the design of more effective educational material by incorporating cognitive social psychological principles; and (5) the utilization of ''hard'' interventions that have a direct, verifiable link to conservation.

Enabling LTE and WiFi Coexisting in 5 GHz for Efficient Spectrum Utilization

Directory of Open Access Journals (Sweden)

Hongyu Sun

2017-01-01

Full Text Available Due to the increasing mobile traffic demands in cellular network, researchers have proposed the coexistence of LTE and WiFi technologies in 5 GHz unlicensed bands. Therefore, how to efficiently utilize the spectrum in 5 GHz becomes extremely important. To avoid the channel access conflicts, current LTE Unlicensed (LTE-U technology introduces the duty cycle of LTE, while License-Assisted Access (LAA technology introduces Listen-Before-Talk (LBT mechanism. While these two technologies improve the spectrum utilization by using time division access schema, we believe that more efficient spectrum utilization can be achieved by enabling simultaneous transmissions from LTE and WiFi. In this paper, we propose a novel method (i.e., Low Amplitude Stream Injection (LASI method to enable the simultaneous transmissions of WiFi and LTE frames in the same channel and recover the data from the conflicts. To further utilize the LASI method, we introduce the Conflict-Tolerant Channel Allocation (CTCA algorithm to optimize the channel allocation and achieve more efficient spectrum utilization in 5 GHz. Extensive simulation results show that our approach achieves lower latency and higher throughput. Compared with the state-of-the-art LTE-U and LAA technologies, our approach can improve the spectrum efficiency 2.9 times.

The application of psoralens to the study of DNA structure, function and dynamics

Energy Technology Data Exchange (ETDEWEB)

Spielmann, Peter Hans [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry

1991-04-01

A series of six nitroxide spin-labeled psoralens were designed, synthesized and tested as probes for DNA dynamics. The synthesis of these spin-labeled psoralen derivatives and their photoreactivity with double-stranded DNA fragments is described. The spin labels (nitroxides) were demonstrated to survive the uv irradiation required to bind the probe to the target DNA. EPR spectra of the photobound spin-labels indicate that they do not wobble with respect to the DNA on the time-scales investigated. The author has used psoralen modified DNA as a model for the study of DNA repair enzyme systems in human cell free extracts. He has shown that damage-induced DNA synthesis is associated with removal of psoralen adducts and therefore is "repair synthesis" and not an aberrant DNA synthesis reaction potentiated by deformation of the DNA by adducts. He has found that all DNA synthesis induced by psoralen monoadducts is the consequence of removal of these adducts. By the same approach he has obtained evidence that this in vitro system is capable of removing psoralen cross-links as well. Reported here are synthetic methods that make use of high intensity lasers coupled with HPLC purification to make homogeneous and very pure micromole quantities of furan-side monoadducted, cross-linked, and pyrone-side monoadducted DNA oligonucleotide. These molecules are currently being studied by NMR and X-ray crystallography. The application of the site-specifically psoralen modified oligonucleotide synthesized by these methods to the construction of substrates for the investigation of DNA repair is also discussed.

US utility partnerships

International Nuclear Information System (INIS)

Worthington, B.

1995-01-01

Activities of the United States Energy Association were reviewed, as well as the manner in which its members are benefitting from the Association's programs. The principal cooperative program set up is the Utility Partnership Program, which was described. Through this program the Association is matching US companies, both electric utilities and gas utilities, with counterparts in Eastern Europe or the former Soviet Union. So far, about 25 partnerships were signed, e.g. in the Czech Republic, in Kazakhstan, in Poland, and in Slovakia. It was estimated that the return to the United States from the investments made by the American government in these Utility Partnership Programs has been well over 100-fold

The validity and utility of subtyping bulimia nervosa

NARCIS (Netherlands)

van Hoeken, Daphne; Veling, Wim; Sinke, Sjoukje; Mitchell, James E.; Hoek, Hans W.

Objective: To review the evidence for the validity and utility of subtyping bulimia nervosa (BN) into a purging (BN-P) and a nonpurging subtype (BN-NP), and of distinguishing BN-NP from binge eating disorder (BED), by comparing course, complications, and treatment. Method: A literature search of

The validity and utility of subtyping bulimia nervosa

NARCIS (Netherlands)

van Hoeken, Daphne; Veling, Wim; Sinke, Sjoukje; Mitchell, James E.; Hoek, Hans W.

2009-01-01

Objective: To review the evidence for the validity and utility of subtyping bulimia nervosa (BN) into a purging (BN-P) and a nonpurging subtype (BN-NP), and of distinguishing BN-NP from binge eating disorder (BED), by comparing course, complications, and treatment. Method: A literature search of

Gender Factor in Computer Anxiety, Knowledge and Utilization ...

African Journals Online (AJOL)

The study investigated the influence of computer anxiety and knowledge on computer utilization among senior secondary school students in Ogun state, Nigeria. A sample of four hundred students randomly selected from twenty secondary schools participated in the study. Ex-post facto research design method was adopted ...

Utility Assessment Methods.

Science.gov (United States)

1982-05-01

Raiffa (831, LaValle [891, and other books on decision analysis. 4.2 Risk Attitudes Much recent research has focused on the investigation of various risk...Issacs, G.L., Hamer, R., Chen, J., Chuang, D., Woodworth, G., Molenaar , I., Lewis C., and Libby, D., Manual for the Computer-Assisted Data Analysis (CADA

A program for calculating load coefficient matrices utilizing the force summation method, L218 (LOADS). Volume 1: Engineering and usage

Science.gov (United States)

Miller, R. D.; Anderson, L. R.

1979-01-01

The LOADS program L218, a digital computer program that calculates dynamic load coefficient matrices utilizing the force summation method, is described. The load equations are derived for a flight vehicle in straight and level flight and excited by gusts and/or control motions. In addition, sensor equations are calculated for use with an active control system. The load coefficient matrices are calculated for the following types of loads: translational and rotational accelerations, velocities, and displacements; panel aerodynamic forces; net panel forces; shears and moments. Program usage and a brief description of the analysis used are presented. A description of the design and structure of the program to aid those who will maintain and/or modify the program in the future is included.

Application of fuel cells with heat recovery for integrated utility systems

Science.gov (United States)

Shields, V.; King, J. M., Jr.

1975-01-01

This paper presents the results of a study of fuel cell powerplants with heat recovery for use in an integrated utility system. Such a design provides for a low pollution, noise-free, highly efficient integrated utility. Use of the waste heat from the fuel cell powerplant in an integrated utility system for the village center complex of a new community results in a reduction in resource consumption of 42 percent compared to conventional methods. In addition, the system has the potential of operating on fuels produced from waste materials (pyrolysis and digester gases); this would provide further reduction in energy consumption.

Synthesis of nanosized (polymerization in miniemulsion employing in situ surfactant formation.

Science.gov (United States)

Guo, Yi; Zetterlund, Per B

2011-10-18

A novel method for synthesis of ultrafine polymeric nanoparticles of diameters less than 20 nm has been developed. The method is based on miniemulsion polymerization exploiting combination of the in situ surfactant generation approach (whereby the surfactant is formed at the oil-water interface by reaction between an organic acid and a base) and ultrasonication. Conventional radical polymerization and nitroxide-mediated radical polymerization of styrene have been conducted in miniemulsion using oleic acid/potassium hydroxide, demonstrating that particles with diameters less than 20 nm can be obtained by this approach at surfactant contents much lower than traditionally required in microemulsion polymerizations. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Handbook of evaluation of utility DSM programs

Energy Technology Data Exchange (ETDEWEB)

Hirst, E.; Reed, J. [eds.; Bronfman, B.; Fitzpatrick, G.; Hicks, E.; Hirst, E.; Hoffman, M.; Keating, K.; Michaels, H.; Nadel, S.; Peters, J.; Reed, J.; Saxonis, W.; Schoen, A.; Violette, D.

1991-12-01

Program evaluation has become a central issue in the world of utility integrated resource planning. The DSM programs that utilities were operating to meet federal requirements or to improve customer relations are now becoming big business. DSM is being considered an important resource in a utility`s portfolio of options. In the last five years, the amount of money that utilities have invested in DSM has grown exponentially in most regulatory jurisdictions. Market analysts are now talking about DSM being a $30 billion industry by the end of the decade. If the large volume of DSM-program investments was not enough to highlight the importance of evaluation, then the introduction of regulatory incentives has really focused the spotlight. This handbook was developed through a process that involved many of those people who represent the diverse constituencies of DSM-program evaluation. We have come to recognize the many technical disciplines that must be employed to evaluate DSM programs. An analysis might start out based on the principles of utility load research to find out what happened, but a combination of engineering and statistical methods must be used to ``triangulate`` an estimate of what would have happened without the program. The difference, of course, is that elusive but prized result of evaluation: what happened as the direct result of the DSM program. Technical performance of DSM measures is not the sole determinant of the answer, either. We also recognize the importance of such behavioral attributes of DSM as persistence and free ridership. Finally, DSM evaluation is meaningless without attention to planning an approach, communicating results to relevant decision-makers, and focusing as much on the process as the impacts of the program. These topics are all covered in this handbook.

Sequence- and structure-dependent DNA base dynamics: Synthesis, structure, and dynamics of site and sequence specifically spin-labeled DNA

International Nuclear Information System (INIS)

Spaltenstein, A.; Robinson, B.H.; Hopkins, P.B.

1989-01-01

A nitroxide spin-labeled analogue of thymidine (1a), in which the methyl group is replaced by an acetylene-tethered nitroxide, was evaluated as a probe for structural and dynamics studies of sequence specifically spin-labeled DNA. Residue 1a was incorporated into synthetic deoxyoligonucleotides by using automated phosphite triester methods. 1 H NMR, CD, and thermal denaturation studies indicate that 1a (T) does not significantly alter the structure of 5'-d(CGCGAATT*CGCG) from that of the native dodecamer. EPR studies on monomer, single-stranded, and duplexed DNA show that 1a readily distinguishes environments of different rigidity. Comparison of the general line-shape features of the observed EPR spectra of several small duplexes (12-mer, 24-mer) with simulated EPR spectra assuming isotropic motion suggests that probe 1a monitors global tumbling of small duplexes. Increasing the length of the DNA oligomers results in significant deviation from isotropic motion, with line-shape features similar to those of calculated spectra of objects with isotropic rotational correlation times of 20-100 ns. EPR spectra of a spin-labeled GT mismatch and a T bulge in long DNAs are distinct from those of spin-labeled Watson-Crick paired DNAs, further demonstrating the value of EPR as a tool in the evaluation of local dynamic and structural features in macromolecules

Online performance evaluation of RAID 5 using CPU utilization

Science.gov (United States)

Jin, Hai; Yang, Hua; Zhang, Jiangling

1998-09-01

Redundant arrays of independent disks (RAID) technology is the efficient way to solve the bottleneck problem between CPU processing ability and I/O subsystem. For the system point of view, the most important metric of on line performance is the utilization of CPU. This paper first employs the way to calculate the CPU utilization of system connected with RAID level 5 using statistic average method. From the simulation results of CPU utilization of system connected with RAID level 5 subsystem can we see that using multiple disks as an array to access data in parallel is the efficient way to enhance the on-line performance of disk storage system. USing high-end disk drivers to compose the disk array is the key to enhance the on-line performance of system.

Leveraging network utility management practices for regulatory purposes

International Nuclear Information System (INIS)

2009-11-01

Electric utilities around the globe are entering a phase where they must modernize and implement smart grid technologies. In order to optimize system architecture, asset replacement, and future operating costs, it the utilities must implement robust and flexible asset management structures. This report discussed the ways in which regulators assess investment plans. It focused on the implicit or explicit use of an asset management approach, including principles; processes; input and outputs; decision-making criteria and prioritization methods. The Ontario Energy Board staff were familiarized with the principles and objectives of established and emerging asset management processes and underlying analytic processes, systems and tools in order to ensure that investment information provided by network utilities regarding rates and other applications could be evaluated effectively. Specifically, the report discussed the need for and importance of asset management and provided further details of international markets and their regulatory approaches to asset management. The report also discussed regulatory approaches for review of asset management underlying investment plans as well as an overview of international regulatory practice for review of network utility asset management. It was concluded that options for strengthening regulatory guidance and assessment included utilizing appropriate and effective benchmarking to assess, promote and provide incentives for best practices and steer clear of the potential perverse incentives. 21 tabs., 17 figs., 1 appendix.

About Economy of Fuel at Thermal Power Stations due to Optimization of Utilization Diagram of Power-Generating Equipment

Directory of Open Access Journals (Sweden)

M. V. Svechko

2008-01-01

Full Text Available Problems of rational fuel utilization becomes more and more significant especially for thermal power stations (TPS. Thermal power stations have complicated starting-up diagrams and utilization modes of their technological equipment. Method of diagram optimization of TPS equipment utilization modes has been developed. The method is based on computer analytical model with application of spline-approximation of power equipment characteristics. The method allows to economize fuel consumption at a rate of 15-20 % with accuracy of the predicted calculation not more than 0.25 %.

The view of Japanese utilities on uranium procurement

International Nuclear Information System (INIS)

Kishida, Tetsuji

1991-01-01

Since Japan is entirely dependent on imports to meet its demand for uranium, its foremost consideration is security of supply. From this point of view, the long-term strategy for uranium procurement followed by the Japanese Government and utilities can be summarized in four points; diversification of supply sources, long term contracts, holding of sufficient inventory and self-supply (ie. involvement in exploration activity and mine development). Under this basic strategy, Japanese utilities have made decisions on which suppliers they buy uranium from, and which purchasing method to adopt, based on the principles of securing stable sources of supply and stable prices. This position is reviewed and discussed. (author)

Halogenase engineering and its utility in medicinal chemistry.

Science.gov (United States)

Fraley, Amy E; Sherman, David H

2018-06-15

Halogenation is commonly used in medicinal chemistry to improve the potency of pharmaceutical leads. While synthetic methods for halogenation present selectivity and reactivity challenges, halogenases have evolved over time to perform selective reactions under benign conditions. The optimization of halogenation biocatalysts has utilized enzyme evolution and structure-based engineering alongside biotransformation in a variety of systems to generate stable site-selective variants. The recent improvements in halogenase-catalyzed reactions has demonstrated the utility of these biocatalysts for industrial purposes, and their ability to achieve a broad substrate scope implies a synthetic tractability with increasing relevance in medicinal chemistry. Copyright © 2018 Elsevier Ltd. All rights reserved.

Radioactive reconnaissance in area of utilization ammunition of depleted uranium

International Nuclear Information System (INIS)

Fortuna, D.; Dimitrijevic, D.

2000-01-01

In this paper are presented methods of radioactive reconnaissance and taking of samples in area of utilization ammunition of depleted uranium during the armed aggression of NATO to Yugoslavia (author)

Method for the detection of a magnetic field utilizing a magnetic vortex

Science.gov (United States)

Novosad, Valentyn [Chicago, IL; Buchanan, Kristen [Batavia, IL

2010-04-13

The determination of the strength of an in-plane magnetic field utilizing one or more magnetically-soft, ferromagnetic member, having a shape, size and material whereas a single magnetic vortex is formed at remanence in each ferromagnetic member. The preferred shape is a thin circle, or dot. Multiple ferromagnetic members can also be stacked on-top of each other and separated by a non-magnetic spacer. The resulting sensor is hysteresis free. The sensor's sensitivity, and magnetic saturation characteristics may be easily tuned by simply altering the material, size, shape, or a combination thereof to match the desired sensitivity and saturation characteristics. The sensor is self-resetting at remanence and therefore does not require any pinning techniques.

Surrogate utility estimation by long-term partners and unfamiliar dyads.

Science.gov (United States)

Tunney, Richard J; Ziegler, Fenja V

2015-01-01

To what extent are people able to make predictions about other people's preferences and values?We report two experiments that present a novel method assessing some of the basic processes in surrogate decision-making, namely surrogate-utility estimation. In each experiment participants formed dyads who were asked to assign utilities to health related items and commodity items, and to predict their partner's utility judgments for the same items. In experiment one we showed that older adults in long-term relationships were able to accurately predict their partner's wishes. In experiment two we showed that younger adults who were relatively unfamiliar with one another were also able to predict other people's wishes. Crucially we demonstrated that these judgments were accurate even after partialling out each participant's own preferences indicating that in order to make surrogate utility estimations people engage in perspective-taking rather than simple anchoring and adjustment, suggesting that utility estimation is not the cause of inaccuracy in surrogate decision-making. The data and implications are discussed with respect to theories of surrogate decision-making.

Surrogate utility estimation by long-term partners and unfamiliar dyads

Directory of Open Access Journals (Sweden)

Richard J Tunney

2015-03-01

Full Text Available To what extent are people able to make predictions about other people’s preferences and values? We report two experiments that present a novel method assessing some of the basic processes in surrogate decision-making, namely surrogate-utility estimation. In each experiment participants formed dyads who were asked to assign utilities to health related items and commodity items, and to predict their partner’s utility judgments for the same items. In experiment one we showed that older adults in long-term relationships were able to accurately predict their partner’s wishes. In experiment two we showed that younger adults who were relatively unfamiliar with one another were also able to predict other people’s wishes. Crucially we demonstrated that these judgments were accurate even after partialling out each participant’s own preferences indicating that in order to make surrogate utility estimations people engage in perspective-taking rather than simple anchoring and adjustment, suggesting that utility estimation is not the cause of inaccuracy in surrogate decision-making. The data and implications are discussed with respect to theories of surrogate decision-making.

Partograph utilization and associated factors among obstetric care ...

African Journals Online (AJOL)

Methods: An Institution based cross-sectional study was conducted in June, 2013 on 403 obstetric care providers. A pre-tested and structured ... Being a midwife by profession, on job training, knowledge and attitude of obstetric care providers were factors affecting partograph utilization. Providing on job training for providers ...

Optimal Energy Management for a Smart Grid using Resource-Aware Utility Maximization

Science.gov (United States)

Abegaz, Brook W.; Mahajan, Satish M.; Negeri, Ebisa O.

2016-06-01

Heterogeneous energy prosumers are aggregated to form a smart grid based energy community managed by a central controller which could maximize their collective energy resource utilization. Using the central controller and distributed energy management systems, various mechanisms that harness the power profile of the energy community are developed for optimal, multi-objective energy management. The proposed mechanisms include resource-aware, multi-variable energy utility maximization objectives, namely: (1) maximizing the net green energy utilization, (2) maximizing the prosumers' level of comfortable, high quality power usage, and (3) maximizing the economic dispatch of energy storage units that minimize the net energy cost of the energy community. Moreover, an optimal energy management solution that combines the three objectives has been implemented by developing novel techniques of optimally flexible (un)certainty projection and appliance based pricing decomposition in an IBM ILOG CPLEX studio. A real-world, per-minute data from an energy community consisting of forty prosumers in Amsterdam, Netherlands is used. Results show that each of the proposed mechanisms yields significant increases in the aggregate energy resource utilization and welfare of prosumers as compared to traditional peak-power reduction methods. Furthermore, the multi-objective, resource-aware utility maximization approach leads to an optimal energy equilibrium and provides a sustainable energy management solution as verified by the Lagrangian method. The proposed resource-aware mechanisms could directly benefit emerging energy communities in the world to attain their energy resource utilization targets.

Migrants' utilization of somatic healthcare services in Europe - a systematic review

DEFF Research Database (Denmark)

Nørredam, Marie Louise; Nielsen, Signe Smith; Krasnik, Allan

2010-01-01

on the abstracts. Additional searches were conducted via the references of the selected articles. The final number of studies included was 21. Results: The results suggested a diverging picture regarding utilization of somatic healthcare services by migrants compared to non-migrants in Europe. Overall, migrants......Background: Utilization of services is an important aspect of migrants' access to healthcare. The aim was to review the European literature on utilization of somatic healthcare services related to screening, general practitioner, specialist, emergency room and hospital by adult first......-generation migrants. Our study question was: ‘Are there differences in migrants' utilization of somatic healthcare services compared to non-migrants?' Methods: Publications were identified by a systematic search of PUBMED and EMBASE. Appropriateness of the studies was judged independently by two researchers based...

Cooling clothing utilizing water evaporation

DEFF Research Database (Denmark)

Sakoi, Tomonori; Tominaga, Naoto; Melikov, Arsen Krikor

2014-01-01

. To prevent wet discomfort, the T-shirt was made of a polyester material having a water-repellent silicon coating on the inner surface. The chest, front upper arms, and nape of the neck were adopted as the cooling areas of the human body. We conducted human subject experiments in an office with air......We developed cooling clothing that utilizes water evaporation to cool the human body and has a mechanism to control the cooling intensity. Clean water was supplied to the outer surface of the T-shirt of the cooling clothing, and a small fan was used to enhance evaporation on this outer surface...... temperature ranging from 27.4 to 30.7 °C to establish a suitable water supply control method. A water supply control method that prevents water accumulation in the T-shirt and water dribbling was validated; this method is established based on the concept of the water evaporation capacity under the applied...

original article health services utilization and associated factors

African Journals Online (AJOL)

Abrham

utilization of health services and associated factors in Jimma zone, south west Ethiopia. METHODS: A cross .... The sample size was calculated using Epi-Info 3.3.2 ... Before the start of data collection, the proposal was submitted to the ... Table 1. Health services access in Jimma zone, Southwest Ethiopia, February 2007.

Performance of cryogenic thermoelectric generators in LNG cold energy utilization

International Nuclear Information System (INIS)

Sun Wei; Hu Peng; Chen Zeshao; Jia Lei

2005-01-01

The cold energy of liquefied natural gas (LNG) is generally wasted when the LNG is extracted for utilization. This paper proposes cryogenic thermoelectric generators to recover this cold energy. The theoretical performance of the generator has been analyzed. An analytical method and numerical method of calculation of the optimum parameters of the generator have been demonstrated

Entrez Programming Utilities

Data.gov (United States)

U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

BpWrapper: BioPerl-based sequence and tree utilities for rapid prototyping of bioinformatics pipelines.

Science.gov (United States)

Hernández, Yözen; Bernstein, Rocky; Pagan, Pedro; Vargas, Levy; McCaig, William; Ramrattan, Girish; Akther, Saymon; Larracuente, Amanda; Di, Lia; Vieira, Filipe G; Qiu, Wei-Gang

2018-03-02

Automated bioinformatics workflows are more robust, easier to maintain, and results more reproducible when built with command-line utilities than with custom-coded scripts. Command-line utilities further benefit by relieving bioinformatics developers to learn the use of, or to interact directly with, biological software libraries. There is however a lack of command-line utilities that leverage popular Open Source biological software toolkits such as BioPerl ( http://bioperl.org ) to make many of the well-designed, robust, and routinely used biological classes available for a wider base of end users. Designed as standard utilities for UNIX-family operating systems, BpWrapper makes functionality of some of the most popular BioPerl modules readily accessible on the command line to novice as well as to experienced bioinformatics practitioners. The initial release of BpWrapper includes four utilities with concise command-line user interfaces, bioseq, bioaln, biotree, and biopop, specialized for manipulation of molecular sequences, sequence alignments, phylogenetic trees, and DNA polymorphisms, respectively. Over a hundred methods are currently available as command-line options and new methods are easily incorporated. Performance of BpWrapper utilities lags that of precompiled utilities while equivalent to that of other utilities based on BioPerl. BpWrapper has been tested on BioPerl Release 1.6, Perl versions 5.10.1 to 5.25.10, and operating systems including Apple macOS, Microsoft Windows, and GNU/Linux. Release code is available from the Comprehensive Perl Archive Network (CPAN) at https://metacpan.org/pod/Bio::BPWrapper . Source code is available on GitHub at https://github.com/bioperl/p5-bpwrapper . BpWrapper improves on existing sequence utilities by following the design principles of Unix text utilities such including a concise user interface, extensive command-line options, and standard input/output for serialized operations. Further, dozens of novel methods for

Reuse of coal mining wastes in civil engineering. Part 2: Utilization of minestone

International Nuclear Information System (INIS)

Skarzynska, K.M.

1995-01-01

The oldest method of minestone utilization is reclamation of spoil heaps by adapting them to the landscape by afforestation or agricultural management. The best method is, however, complete removal of the wastes. Hence, for many years research has been carried out to find new ways of minestone utilization to minimize disposal cost and harmful environmental effects. Earth structures offer the best possibilities of minestone utilization. Investigations conducted in recent years in Germany, the United Kingdom, France, Belgium, the Netherlands and also in Poland have led to the use of many tones of wastes in the construction of road and railroad banks, river embankments, dykes and dams, filling of land depressions and open pits, as well as for sea wharfs and land reclamation. This paper presents descriptions of minestone applications to hydraulic, harbor and road engineering as well as to mine backfilling and restoration of derelict land. Effective management of minestone is still the principal problem with respect to safety, economics and environmental protection. Hence, the propagation of minestone utilization of known sources and the search for new methods of its management are essential. Two sections in this review have been devoted to the prevention of spontaneous heating and combustion of minestone and to the impact of minestone structures on the environment and its protection

Utility Green Pricing Programs: Design, Implementation, and Consumer Response

Energy Technology Data Exchange (ETDEWEB)

Bird, L.; Swezey, B.; Aabakken, J.

2004-02-01

The term green pricing refers to programs offered by utilities in traditionally regulated electricity markets, which allow customers to support the development of renewable energy sources by paying a small premium on their electric bills. Since the introduction of the concept in the United States, the number of unique utility green pricing programs has expanded from just a few programs in 1993 to more than 90 in 2002. About 10% of U.S. utilities offered a green pricing option to about 26 million consumers by the end of 2002. This report provides: (1) aggregate industry data on consumer response to utility programs, which indicate the collective impact of green pricing on renewable energy development nationally; and (2) market data that can be used by utilities as a benchmark for gauging the relative success of their green pricing programs. Specifically, the paper presents current data and trends in consumer response to green pricing, as measured by renewable energy sales, participants, participation rates, and new renewable energy capacity supported. It presents data on various aspects of program design and implementation, such as product pricing, ownership of supplies, retention rates, marketing costs, the effectiveness of marketing techniques, and methods of enrolling and providing value to customers.

Determinants of elevated healthcare utilization in patients with COPD

Directory of Open Access Journals (Sweden)

Bernhard-Scharf Barbara J

2011-01-01

Full Text Available Abstract Background Chronic obstructive pulmonary disease (COPD imparts a substantial economic burden on western health systems. Our objective was to analyze the determinants of elevated healthcare utilization among patients with COPD in a single-payer health system. Methods Three-hundred eighty-nine adults with COPD were matched 1:3 to controls by age, gender and area of residency. Total healthcare cost 5 years prior recruitment and presence of comorbidities were obtained from a computerized database. Health related quality of life (HRQoL indices were obtained using validated questionnaires among a subsample of 177 patients. Results Healthcare utilization was 3.4-fold higher among COPD patients compared with controls (p Conclusion Comorbidity burden determines elevated utilization for COPD patients. Decision makers should prioritize scarce health care resources to a better care management of the "most costly" patients.

Accelerating experience : utility sector case studies in training and knowledge management

Energy Technology Data Exchange (ETDEWEB)

Trudel-Ferrari, C.C. [Kinectrics Inc., Toronto, ON (Canada)

2010-07-01

This paper discussed the development of effective training and knowledge management systems for recently hired personnel in electric utilities. Case studies of best practices from electric utilities in Ontario, consultants, and universities were used to develop an overview of current training practices. Methods of identifying, attracting, and recruiting personnel were presented and knowledge management and mentoring programs were discussed. The use of training programs in developing knowledge databases was also evaluated. Knowledge management formats included qualification training; simulation training; knowledge transfer; and curriculum development. Human resources, revenue, and management issues currently challenging electric utilities were discussed along with various new training practices. 2 refs., 3 tabs., 2 figs.

Development of the multi-attribute Adolescent Health Utility Measure (AHUM

Directory of Open Access Journals (Sweden)

Beusterien Kathleen M

2012-08-01

Full Text Available Abstract Objective Obtain utilities (preferences for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions. Methods A health state classification system, the Adolescent Health Utility Measure (AHUM, was developed based on generic health status measures and input from children with Hunter syndrome and their caregivers. The AHUM contains six dimensions with 4–7 severity levels: self-care, pain, mobility, strenuous activities, self-image, and health perceptions. Using the time trade off (TTO approach, a UK population sample provided utilities for 62 of 16,800 AHUM states. A mixed effects model was used to estimate utilities for the AHUM states. The AHUM was applied to trial NCT00069641 of idursulfase for Hunter syndrome and its extension (NCT00630747. Results Observations (i.e., utilities totaled 3,744 (12*312 participants, with between 43 to 60 for each health state except for the best and worst states which had 312 observations. The mean utilities for the best and worst AHUM states were 0.99 and 0.41, respectively. The random effects model was statistically significant (p  Discussion The AHUM health state classification system may be used in future research to enable calculation of quality-adjust life expectancy for applicable health conditions.

Novel Emergency Medicine Curriculum Utilizing Self-Directed Learning and the Flipped Classroom Method: Gastrointestinal Emergencies Small Group Module

Directory of Open Access Journals (Sweden)

Andrew King

2017-01-01

Full Text Available Audience and type of curriculum: This curriculum created and implemented at The Ohio State University Wexner Medical Center was designed to educate our emergency medicine (EM residents, PGY-1 to PGY-3, as well as medical students and attending physicians. Introduction/Background: Gastrointestinal (GI emergencies comprise approximately 12% of emergency department (ED visits.1 Residents must be proficient in the differential diagnosis and management of the wide variety of GI emergencies. The flipped classroom curricular model emphasizes self-directed learning activities completed by learners, followed by small group discussions pertaining to the topic reviewed. The active learning fostered by this curriculum increases faculty and learner engagement and interaction time typically absent in traditional lecture-based formats.2-4 Studies have revealed that the application of knowledge through case studies, personal interaction with content experts, and integrated questions are effective learning strategies for emergency medicine residents.4-6 The Ohio State University EM Residency didactic curriculum recently transitioned to a “flipped classroom” approach.7-10 We created this innovative curriculum aimed to improve our residency education program and to share educational resources with other EM residency programs. This proposed curriculum utilizes an 18-month curricular cycle. The flipped classroom curriculum maximizes didactic time and resident engagement, fosters intellectual curiosity and active learning, and meets the needs of today’s learners. 3,6,11 Objectives: We aim to teach the presentation and management of GI emergencies through the creation of a flipped classroom design. This unique, innovative curriculum utilizes resources chosen by education faculty and resident learners, study questions, real-life experiences, and small group discussions in place of traditional lectures. In doing so, a goal of the curriculum is to encourage self

The changing utility workforce and the emergence of building information modeling in utilities

Energy Technology Data Exchange (ETDEWEB)

Saunders, A. [Autodesk Inc., San Rafael, CA (United States)

2010-07-01

Utilities are faced with the extensive replacement of a workforce that is now reaching retirement age. New personnel will have varying skill levels and different expectations in relation to design tools. This paper discussed methods of facilitating knowledge transfer from the retiring workforce to new staff using rules-based design software. It was argued that while nothing can replace the experiential knowledge of long-term engineers, software with built-in validations can accelerate training and building information modelling (BIM) processes. Younger personnel will expect a user interface paradigm that is based on their past gaming and work experiences. Visualization, simulation, and modelling approaches were reviewed. 3 refs.

Introducing a novel method to estimate the total heat transfer coefficient inside irregular-shape cavities utilizing thermoelectric modules; Special application in solar engineering

DEFF Research Database (Denmark)

Asadi, Amin; Rahbar, Nader; Rezaniakolaei, Alireza

The main objective of the present study is to introduce a novel method to measure the total heat transfer coefficient inside irregular-shape cavities, used in solar applications, utilizing thermoelectric modules. Applying mathematical and thermodynamics modeling, the governing equations related...... to the total heat transfer coefficient between thermoelectric and glass cover as a function of ambient temperature, glass temperature, and output voltage has been derived. Investigating the accuracy of the proposed equation, an experimental case study has been performed. The experimental setup consists...... of three parts; a heat sink, a thermoelectric module, and a glass cover. All the experiments have been performed on the typical winter day and under the real climatic conditions of Semnan (35° 33′ N, 53° 23′ E), Iran. The results showed that the proposed method has the ability to measure the total heat...

Research of environmentally-friendly utilization methods of the crushed stone waste on granite quarries

Directory of Open Access Journals (Sweden)

Levytskyi V.G.

2017-12-01

Full Text Available The analysis of activity of stone-mining enterprises shows the low competitiveness of crushed stone products Upgrading the quality of crushed stone and production of the European standard fractions requires to use of new technologies and equipment. The main waste of crushed stone pits is сrushed granite waste, which high percent of an exit is caused by outdated equipment and incorrectly selected technological parameters of the crushing process. Crushed-granite waste is stored in dumps which occupy large areas and negatively effect on production area ecology. In November 2017, the Government of Ukraine accepted the National Waste Management Strategy until 2030, the main aim of it is develop a strategy of the mineral raw materials balanced use and international standards introduction at the national level. Therefore, the problem of complex utilization and recycling of waste from stone-mining enterprises with receiving a qualitative secondary product is relevant. The publication presents the сrushed granite waste volumes by crushed stone pit, its properties and main directions of utilization. The ecological influence of waste dumps, in particular granite dust, on the environment and human, the strategy of using non-waste technologies and ecological features of сrushed granite waste secondary processing are considered

Beyond Widgets -- Systems Incentive Programs for Utilities

Energy Technology Data Exchange (ETDEWEB)

Regnier, Cindy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mathew, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Robinson, Alastair [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schwartz, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walter, Travis [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-08-15

Utility incentive programs remain one of the most significant means of deploying commercialized, but underutilized building technologies to scale. However, these programs have been largely limited to component-based products (e.g., lamps, RTUs). While some utilities do provide ‘custom’ incentive programs with whole building and system level technical assistance, these programs require deeper levels of analysis, resulting in higher program costs. This results in custom programs being restricted to utilities with greater resources, and are typically applied mainly to large or energy-intensive facilities, leaving much of the market without cost effective access and incentives for these solutions. In addition, with increasingly stringent energy codes, cost effective component-based solutions that achieve significant savings are dwindling. Building systems (e.g., integrated façade, HVAC and/or lighting solutions) can deliver higher savings that translate into large sector-wide savings if deployed at the scale of these programs. However, systems application poses a number of challenges – baseline energy use must be defined and measured; the metrics for energy and performance must be defined and tested against; in addition, system savings must be validated under well understood conditions. This paper presents a sample of findings of a project to develop validated utility incentive program packages for three specific integrated building systems, in collaboration with Xcel Energy (CO, MN), ComEd, and a consortium of California Public Owned Utilities (CA POUs) (Northern California Power Agency(NCPA) and the Southern California Public Power Authority(SCPPA)). Furthermore, these program packages consist of system specifications, system performance, M&V protocols, streamlined assessment methods, market assessment and implementation guidance.

[Unwanted adolescent pregnancy and post-partum utilization of contraceptive methods].

Science.gov (United States)

Núñez-Urquiza, Rosa María; Hernández-Prado, Bernardo; García-Barrios, Cecilia; González, Dolores; Walker, Dylis

2003-01-01

To describe the proportion of unwanted pregnancies among all pregnant adolescents, its association with sociodemographic characteristics, and the use of post-partum contraceptive methods. A cross-sectional study was conducted among 220 women between 13 and 19 years of age, in two semi-urban municipalities of the State of Morelos, Mexico, interviewed between 1992 and 1994. Women were interviewed at home, six to twelve weeks after their delivery date. Women were asked whether they had wanted their last pregnancy, and about knowledge and use of contraceptive methods after delivery. Adolescent pregnancies accounted for 17% of all births registered in these two municipalities. Among all adolescent mother 22.73% reported that their pregnancy had not been wanted. A positive association was found between the lack of access to health services provided by public medical insurance systems (Instituto Mexicano del Seguro Social IMSS and Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado ISSSTE) and unwanted pregnancy (adjusted OR = 3.03, 95% CI (1.31, 7.) An association was also found between living in an urban community (adjusted OR = 2.16, 95% CI (1.08, 4.33) and an unwanted pregnancy. Among all adolescent mothers, 91.3% were familiar with "the pill" as a contraceptive method; 84.72% knew about the IUD, and 63.68% knew about the condom. However, only 35% of them were actually using an effective contraceptive method six weeks after delivery. No difference in frequency of contraceptive use was found among the adolescent mothers, according to whether they wanted their last pregnancy. Only 43.39% of mothers who delivered at hospitals or health centers were using an effective contraceptive method. These findings suggest that there is a great potential for family planning programs to target adolescents, and that the use of contraceptive methods after delivery should be promoted among adolescent mothers, especially those lacking access to public medical

Utility franchises reconsidered

Energy Technology Data Exchange (ETDEWEB)

Weidner, B.

1981-11-01

It is easier to obtain a public utility franchise than one for a fast food store because companies like Burger King value the profit share and control available with a franchise arrangement. The investor-owned utilities (IOUs) in Chicago and elsewhere gets little financial or regulatory benefit, although they do have an alternative because the franchise can be taken over by the city with a one-year notice. As IOUs evolved, the annual franchise fee has been incorporated into the rate in a move that taxes ratepayers and maximizes profits. Cities that found franchising unsatisfactory are looking for ways to terminate the franchise and finance a takeover, but limited-term and indeterminate franchises may offer a better mechanism when public needs and utility aims diverge. A directory lists franchised utilities by state and comments on their legal status. (DCK)

Utility Computing: Reality and Beyond

Science.gov (United States)

Ivanov, Ivan I.

Utility Computing is not a new concept. It involves organizing and providing a wide range of computing-related services as public utilities. Much like water, gas, electricity and telecommunications, the concept of computing as public utility was announced in 1955. Utility Computing remained a concept for near 50 years. Now some models and forms of Utility Computing are emerging such as storage and server virtualization, grid computing, and automated provisioning. Recent trends in Utility Computing as a complex technology involve business procedures that could profoundly transform the nature of companies' IT services, organizational IT strategies and technology infrastructure, and business models. In the ultimate Utility Computing models, organizations will be able to acquire as much IT services as they need, whenever and wherever they need them. Based on networked businesses and new secure online applications, Utility Computing would facilitate "agility-integration" of IT resources and services within and between virtual companies. With the application of Utility Computing there could be concealment of the complexity of IT, reduction of operational expenses, and converting of IT costs to variable `on-demand' services. How far should technology, business and society go to adopt Utility Computing forms, modes and models?

Agricultural field reclamation utilizing native grass crop production

Science.gov (United States)

J. Cure

2013-01-01

Developing a method of agricultural field reclamation to native grasses in the Lower San Pedro Watershed could prove to be a valuable tool for educational and practical purposes. Agricultural field reclamation utilizing native grass crop production will address water table depletion, soil degradation and the economic viability of the communities within the watershed....

High-Performance Harmonic Isolation and Load Voltage Regulation of the Three-Phase Series Active Filter Utilizing the Waveform Reconstruction Method

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Hava, Ahmet M.

2009-01-01

. The SAF-compensated system utilizing WRM provides highperformance load harmonic voltage isolation and load voltage regulation at steady-state and during transients compared to the system utilizing the synchronous reference-frame-based signal decomposition. In addition, reducing the line current sampling...

Electric utility resource expansion planning using environmental externalities

International Nuclear Information System (INIS)

Mitchell, D.

1992-01-01

This paper describes the recent experience of San Diego Gas ampersand Electric Company using environmental externalities in the expansion planning of its electrical system. This is the first time that this method of planning has been used in the electric utility industry in California. The paper reviews the conceptual development of the monetary values for environmental externalities and shows how the application of these values modifies the resource selection process. This paper should be of interest to professionals involved in policy issues relating to the use of environmental externalities as a means to improve the environment. The experience gained through this analyses should also benefit electric utility personnel involved in planning, and regulators interested in planning

Recommended methods for evaluating the benefits of ECUT Program outputs. [Energy Conversion and Utilization

Energy Technology Data Exchange (ETDEWEB)

Levine, L.O.; Winter, C.

1986-03-01

This study was conducted to define and develop techniques that could be used to assess the complete spectrum of positive effects resulting from the Energy Conversion and Utilization Technologies (ECUT) Program activities. These techniques could then be applied to measure the benefits from past ECUT outputs. In addition, the impact of future ECUT outputs could be assessed as part of an ongoing monitoring process, after sufficient time has elapsed to allow their impacts to develop.

Pressurization Risk Assessment of CO2 Reservoirs Utilizing Design of Experiments and Response Surface Methods

Science.gov (United States)

Guyant, E.; Han, W. S.; Kim, K. Y.; Park, E.; Han, K.

2015-12-01

Monitoring of pressure buildup can provide explicit information on reservoir integrity and is an appealing tool, however pressure variation is dependent on a variety of factors causing high uncertainty in pressure predictions. This work evaluated pressurization of a reservoir system in the presence of leakage pathways as well as exploring the effects of compartmentalization of the reservoir utilizing design of experiments (Definitive Screening, Box Behnken, Central Composite, and Latin Hypercube designs) and response surface methods. Two models were developed, 1) an idealized injection scenario in order to evaluate the performance of multiple designs, and 2) a complex injection scenario implementing the best performing design to investigate pressurization of the reservoir system. A holistic evaluation of scenario 1, determined that the Central Composite design would be used for the complex injection scenario. The complex scenario evaluated 5 risk factors: reservoir, seal, leakage pathway and fault permeabilities, and horizontal position of the pathway. A total of 60 response surface models (RSM) were developed for the complex scenario with an average R2 of 0.95 and a NRMSE of 0.067. Sensitivity to the input factors was dynamic through space and time; at the earliest time (0.05 years) the reservoir permeability was dominant, and for later times (>0.5 years) the fault permeability became dominant for all locations. The RSM's were then used to conduct a Monte Carlo Analysis to further analyze pressurization risks, identifying the P10, P50, P90 values. This identified the in zone (lower) P90 values as 2.16, 1.77, and 1.53 MPa and above zone values of 1.35, 1.23, 1.09 MPa for monitoring locations 1, 2, and 3, respectively. In summary, the design of experiments and response surface methods allowed for an efficient sensitivity and uncertainty analysis to be conducted permitting a complete evaluation of the pressurization across the entire parameter space.

Outpatient utilization of psychopharmaceuticals in the City of Zagreb 2001-2006.

Science.gov (United States)

Stimac, Danijela; Culig, Josip

2009-03-01

A comprehensive insight into drug utilization as an economic and primarily a public health issue can only be acquired in the context of overall health state of the respective population. The objectives of the study were: 1) to determine the real outpatient utilization of psychopharmaceuticals in Zagreb, 2) to determine the psychopharmaceutical prescribing quality during the study period; and 3) to propose appropriate interventions in Zagreb on the basis of the results obtained. Data on drug utilization were obtained from all Zagreb pharmacies. The number of defined daily doses (DDD) and number of DDD per 1000 inhabitants per day (DDD/1000/day) were calculated from the number of particular drug packages. The Drug Utilization 90% (DU90%) method was used as a criterion of prescribing quality. Outpatient utilization of psychopharmaceuticals showed a declining pattern from 115.40 DDD/1000/day in 2001 to 93.15 DDD/1000/day in 2006. Anxiolytics accounted for the majority of this drug group utilization in the City of Zagreb, although the anxiolytic/antidepressant ratio decreased from 7.19 in 2001 to 3.86 in 2006. The utilization of selective serotonin reuptake inhibitors showed a 2.5-fold increase and accounted for 90% of overall antidepressant utilization. A 2.5-fold decrease was recorded in the utilization of antipsychotics, while the atypical/typical antipsychotic ratio changed from 1:2 in 2001 to 1.1:1 in 2006. Despite some improvement observed in the prescribing quality, the predominance of benzodiazepines in the utilization of psychopharmaceuticals points to the need of additional rationalization in the field.

Evaluation utilization research--developing a theory and putting it to use.

Science.gov (United States)

Neuman, Ari; Shahor, Neria; Shina, Ilan; Sarid, Anat; Saar, Zehava

2013-02-01

This article presents the findings of a two-stage study that had two key objectives: to develop a theory about evaluation utilization in an educational organization and to apply this theory to promote evaluation utilization within the organization. The first stage involved a theoretical conceptualization using a participatory method of concept mapping. This process identified the modes of evaluation utilization within the organization, produced a representation of the relationship between them and led to a theory. The second stage examined the practical implications of this conceptualization in terms of how different stakeholders in the organization perceive the actual and preferable state of evaluation utilization within the organization (i.e. to what extent is evaluation utilized and to what extent should it be utilized). The participatory process of the study promoted the evaluation utilization by involving stakeholders, thus giving them a sense of ownership and improving communication between the evaluation unit and the stakeholders. In addition, understanding the evaluation needs of the stakeholders in the organization helped generate relevant and realizable evaluation processes. On a practical level, the results are currently shaping the evaluation plan and the place of evaluations within the organization. Copyright © 2012 Elsevier Ltd. All rights reserved.

Focus on vulnerable populations and promoting equity in health service utilization ––an analysis of visitor characteristics and service utilization of the Chinese community health service

OpenAIRE

Dong, Xiaoxin; liu, Ling; Cao, Shiyi; Yang, Huajie; Song, Fujian; Yang, Chen; Gong, Yanhong; Wang, Yunxia; Yin, Xiaoxu; Xie, Jun; Sun, Yi; Lu, Zuxun

2014-01-01

Background Community health service in China is designed to provide a convenient and affordable primary health service for the city residents, and to promote health equity. Based on data from a large national study of 35 cities across China, we examined the characteristics of the patients and the utilization of community health institutions (CHIs), and assessed the role of community health service in promoting equity in health service utilization for community residents. Methods Multistage sa...

A study of economic utility resulting from CERN

International Nuclear Information System (INIS)

Schmied, H.

1975-01-01

The study attempts to quantify the technical and economic benefit to the manufacturing industries involved in CERN contracts, in relation to the expenditures on CERN by its Member States. Interviews were carried out in some 130 European firms, who supplied data on estimates of increased sales and decreased costs due to CERN contracts. This 'economic utility' totals 1,665 million Swiss francs (up to the year 1978), compared with a sales value to CERN of 394 MSF. Utility/sales ratios range from 0.9 to 7.3 for application fields of cables, magnets, cooling systems, vacuum equipment, electronics, and steels; they are as high as 17.3 for computers and 31.6 for precision mechanics. Some 80 per cent of the total reported utility results from sales to markets outside high-energy and nuclear physics, for example, railways, ship-building, refrigeration, power generation and power distribution. For the 877 MSF spent by CERN in European industry from its over-all budget of 3,500 MSF during 1955 to 1973, the total utility is estimated to be nearly 5,000 MSF. The method and procedure of analysis and quantification are discussed in detail and some specific cases are presented as examples. (author)

Quantifying the utility of taking pills for preventing adverse health outcomes: a cross-sectional survey.

Science.gov (United States)

Hutchins, Robert; Pignone, Michael P; Sheridan, Stacey L; Viera, Anthony J

2015-05-11

The utility value attributed to taking pills for prevention can have a major effect on the cost-effectiveness of interventions, but few published studies have systematically quantified this value. We sought to quantify the utility value of taking pills used for prevention of cardiovascular disease (CVD). Cross-sectional survey. Central North Carolina. 708 healthcare employees aged 18 years and older. Utility values for taking 1 pill/day, assessed using time trade-off, modified standard gamble and willingness-to-pay methods. Mean age of respondents was 43 years (19-74). The majority of the respondents were female (83%) and Caucasian (80%). Most (80%) took at least 2 pills/day. Mean utility values for taking 1 pill/day using the time trade-off method were: 0.9972 (95% CI 0.9962 to 0.9980). Values derived from the standard gamble and willingness-to-pay methods were 0.9967 (0.9954 to 0.9979) and 0.9989 (95% CI 0.9986 to 0.9991), respectively. Utility values varied little across characteristics such as age, sex, race, education level or number of pills taken per day. The utility value of taking pills daily in order to prevent an adverse CVD health outcome is approximately 0.997. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Utility measurement in healthcare: the things I never got to.

Science.gov (United States)

Torrance, George W

2006-01-01

The present article provides a brief historical background on the development of utility measurement and cost-utility analysis in healthcare. It then outlines a number of research ideas in this field that the author never got to. The first idea is extremely fundamental. Why is health economics the only application of economics that does not use the discipline of economics? And, more importantly, what discipline should it use? Research ideas are discussed to investigate precisely the underlying theory and axiom systems of both Paretian welfare economics and the decision-theoretical utility approach. Can the two approaches be integrated or modified in some appropriate way so that they better reflect the needs of the health field? The investigation is described both for the individual and societal levels. Constructing a 'Robinson Crusoe' society of only a few individuals with different health needs, preferences and willingness to pay is suggested as a method for gaining insight into the problem. The second idea concerns the interval property of utilities and, therefore, QALYs. It specifically concerns the important requirement that changes of equal magnitude anywhere on the utility scale, or alternatively on the QALY scale, should be equally desirable. Unfortunately, one of the original restrictions on utility theory states that such comparisons are not permitted by the theory. It is shown, in an important new finding, that while this restriction applies in a world of certainty, it does not in a world of uncertainty, such as healthcare. Further research is suggested to investigate this property under both certainty and uncertainty. Other research ideas that are described include: the development of a precise axiomatic basis for the time trade-off method; the investigation of chaining as a method of preference measurement with the standard gamble or time trade-off; the development and training of a representative panel of the general public to improve the completeness

WEALTH EFFECT AND DENTAL CARE UTILIZATION IN THE U.S.

Science.gov (United States)

Manski, Richard J.; Moeller, John F.; Chen, Haiyan; Clair, Patricia A. St.; Schimmel, Jody; Pepper, John V.

2012-01-01

Objective The purpose of this article is to examine the relationship of wealth and income and the relative impact of each on dental utilization in a population of older Americans, using data from the Health and Retirement Study (HRS). Methods Data from the Health and Retirement Study (HRS) were analyzed for U.S. individuals aged 51 years and older during the 2008 wave of the HRS. The primary focus of the analysis is the relationship between wealth, income and dental utilization. We estimate a multivariable model of dental use controlling for wealth, income and other potentially confounding covariates. Results We find that both wealth and income each have a strong and independent positive effect on dental care use of older Americans [pdental care utilization as wealth increases depends on a person's income level, or, alternatively, that the impact on dental use as income increases depends on a person's household wealth status [p>.05]. Conclusions Relative to those living in the wealthiest U.S. households, the likelihood of utilizing dental care appears to decrease with a decline in wealth. The likelihood of utilizing dental care also appears to decrease with a decline in income as well. PMID:22515635

Productivity growth and price regulation of Slovenian water distribution utilities

Directory of Open Access Journals (Sweden)

Jelena Zorić

2010-06-01

Full Text Available This paper aims to analyse the price regulation method and performance of thewater industry in Slovenia. A stochastic cost frontier model is employed to estimate and decompose the total factor productivity (TFP growth of water distribution utilities in the 1997-2003 period. The main goal is to find out whether the lack of proper incentives to improve performance has resulted in the low TFP growth of Slovenian water distribution utilities. The evidence suggests that cost inefficiencies are present in water utilities, which indicates considerable cost saving potential in the analysed industry. Technical change is found to have positively affected the TFP growth over time, while cost inefficiency levels remained essentially unchanged. Overall, the average annual TFP growth in the analysed period is estimated to be only slightly above zero, which is a relatively poor result. This can largely be contributed to the present institutional and regulatory setting that does not stimulate utilities to improve productivity. Therefore, the introduction of an independent regulatory agency and an incentive-based price regulation scheme should be seriously considered in order to enhance the performance of Slovenian water distribution utilities.

Dynamic Functional Imaging of Brain Glucose Utilization using fPET-FDG

Science.gov (United States)

Villien, Marjorie; Wey, Hsiao-Ying; Mandeville, Joseph B.; Catana, Ciprian; Polimeni, Jonathan R.; Sander, Christin Y.; Zürcher, Nicole R.; Chonde, Daniel B.; Fowler, Joanna S.; Rosen, Bruce R.; Hooker, Jacob M.

2014-01-01

Glucose is the principal source of energy for the brain and yet the dynamic response of glucose utilization to changes in brain activity is still not fully understood. Positron emission tomography (PET) allows quantitative measurement of glucose metabolism using 2-[18F]-fluorodeoxyglucose (FDG). However, FDG PET in its current form provides an integral (or average) of glucose consumption over tens of minutes and lacks the temporal information to capture physiological alterations associated with changes in brain activity induced by tasks or drug challenges. Traditionally, changes in glucose utilization are inferred by comparing two separate scans, which significantly limits the utility of the method. We report a novel method to track changes in FDG metabolism dynamically, with higher temporal resolution than exists to date and within a single session. Using a constant infusion of FDG, we demonstrate that our technique (termed fPET-FDG) can be used in an analysis pipeline similar to fMRI to define within-session differential metabolic responses. We use visual stimulation to demonstrate the feasibility of this method. This new method has a great potential to be used in research protocols and clinical settings since fPET-FDG imaging can be performed with most PET scanners and data acquisition and analysis is straightforward. fPET-FDG is a highly complementary technique to MRI and provides a rich new way to observe functional changes in brain metabolism. PMID:24936683

Magnetic and transport properties of conjugated and cumulated molecules: the π-system enlightens part of the story

DEFF Research Database (Denmark)

Sarbadhikary, Prodipta; Shil, Suranjan; Misra, Anirban

2018-01-01

We have investigated the intramolecular magnetic exchange coupling constants (J) for a series of nitronyl nitroxide diradicals connected by a range of linear conjugated and cumulene couplers focusing on the unusual π-interaction properties within the couplers. Distance between radical centers, sp...

Dynameomics: Data-driven methods and models for utilizing large-scale protein structure repositories for improving fragment-based loop prediction

Science.gov (United States)

Rysavy, Steven J; Beck, David AC; Daggett, Valerie

2014-01-01

Protein function is intimately linked to protein structure and dynamics yet experimentally determined structures frequently omit regions within a protein due to indeterminate data, which is often due protein dynamics. We propose that atomistic molecular dynamics simulations provide a diverse sampling of biologically relevant structures for these missing segments (and beyond) to improve structural modeling and structure prediction. Here we make use of the Dynameomics data warehouse, which contains simulations of representatives of essentially all known protein folds. We developed novel computational methods to efficiently identify, rank and retrieve small peptide structures, or fragments, from this database. We also created a novel data model to analyze and compare large repositories of structural data, such as contained within the Protein Data Bank and the Dynameomics data warehouse. Our evaluation compares these structural repositories for improving loop predictions and analyzes the utility of our methods and models. Using a standard set of loop structures, containing 510 loops, 30 for each loop length from 4 to 20 residues, we find that the inclusion of Dynameomics structures in fragment-based methods improves the quality of the loop predictions without being dependent on sequence homology. Depending on loop length, ∼25–75% of the best predictions came from the Dynameomics set, resulting in lower main chain root-mean-square deviations for all fragment lengths using the combined fragment library. We also provide specific cases where Dynameomics fragments provide better predictions for NMR loop structures than fragments from crystal structures. Online access to these fragment libraries is available at http://www.dynameomics.org/fragments. PMID:25142412

Dynameomics: data-driven methods and models for utilizing large-scale protein structure repositories for improving fragment-based loop prediction.

Science.gov (United States)

Rysavy, Steven J; Beck, David A C; Daggett, Valerie

2014-11-01

Protein function is intimately linked to protein structure and dynamics yet experimentally determined structures frequently omit regions within a protein due to indeterminate data, which is often due protein dynamics. We propose that atomistic molecular dynamics simulations provide a diverse sampling of biologically relevant structures for these missing segments (and beyond) to improve structural modeling and structure prediction. Here we make use of the Dynameomics data warehouse, which contains simulations of representatives of essentially all known protein folds. We developed novel computational methods to efficiently identify, rank and retrieve small peptide structures, or fragments, from this database. We also created a novel data model to analyze and compare large repositories of structural data, such as contained within the Protein Data Bank and the Dynameomics data warehouse. Our evaluation compares these structural repositories for improving loop predictions and analyzes the utility of our methods and models. Using a standard set of loop structures, containing 510 loops, 30 for each loop length from 4 to 20 residues, we find that the inclusion of Dynameomics structures in fragment-based methods improves the quality of the loop predictions without being dependent on sequence homology. Depending on loop length, ∼ 25-75% of the best predictions came from the Dynameomics set, resulting in lower main chain root-mean-square deviations for all fragment lengths using the combined fragment library. We also provide specific cases where Dynameomics fragments provide better predictions for NMR loop structures than fragments from crystal structures. Online access to these fragment libraries is available at http://www.dynameomics.org/fragments. © 2014 The Protein Society.

OAM system based on TMN for utility telecommunication network. Proposal of modeling method about managed objects; TMN ni motozuku denryoku tsushinmo no un`yo kanri system. Kanri object no sekkei shuho ni kansuru kento

Energy Technology Data Exchange (ETDEWEB)

Hirozawa, T.; Yusa, H.; Otani, T. [Central Research Institute of Electric Power Industry, Tokyo (Japan); Okamura, K. [Tokyo Electric Power Co. Inc., Tokyo (Japan)

1996-03-01

To construct an advanced operation and management system for utility telecommunications management network (TMN), this paper proposes a modeling method of managed objects (MOs) required for managing and managed systems, such as an asynchronous transmission mode (ATM) exchanger. Flexible line setting and path switching control are required for the advanced TMN, which must cope with the extension and modification of functions, flexibly. Assignment of roles of managing sides and managed sides was determined. Then, structures of objects such as facilities and logic data, and their interaction were modeled. Common management functions and objects of each function were classified. Based on the TMN standard and MOs of the existing design peculiar to utility, new MOs peculiar to utility were defined in response to the models. The existing MOs can be effectively utilized, and the optimum MOs to be incorporated can be expected. The MOs peculiar to utility are added to the common specification of electric power industry. Since they can be reused for the extension and modification of functions, the cost can be reduced. The MOs applicable to path switching control of utility were designed as a trial. 9 refs., 16 figs., 10 tabs.

Comprehensive Smart Grid Planning in a Regulated Utility Environment

Science.gov (United States)

Turner, Matthew; Liao, Yuan; Du, Yan

2015-06-01

This paper presents the tools and exercises used during the Kentucky Smart Grid Roadmap Initiative in a collaborative electric grid planning process involving state regulators, public utilities, academic institutions, and private interest groups. The mandate of the initiative was to assess the existing condition of smart grid deployments in Kentucky, to enhance understanding of smart grid concepts by stakeholders, and to develop a roadmap for the deployment of smart grid technologies by the jurisdictional utilities of Kentucky. Through involvement of many important stakeholder groups, the resultant Smart Grid Deployment Roadmap proposes an aggressive yet achievable strategy and timetable designed to promote enhanced availability, security, efficiency, reliability, affordability, sustainability and safety of the electricity supply throughout the state while maintaining Kentucky's nationally competitive electricity rates. The models and methods developed for this exercise can be utilized as a systematic process for the planning of coordinated smart grid deployments.

Calorimetric and spectroscopic properties of small globular proteins (bovine serum albumin, hemoglobin) after free radical generation

International Nuclear Information System (INIS)

Farkas, N.; Belagyi, J.; Lorinczy, D.

2003-01-01

Mild oxidation of -SH-containing proteins (serum albumin, hemoglobin) by Ce(IV)-ions in the presence of the spin trap phenyl-tert-butylnitrone (PBN) resulted in the appearance of strongly immobilized nitroxide free radicals which evidences the formation of thiyl radicals on the thiol site of the proteins. In hydroxyl free radical generating system a fraction of strongly immobilized nitroxide radicals was also detected in these proteins, which implies that the oxidation of a fraction of the thiol groups was also involved in the free radical reaction. According to the differential scanning calorimetry (DSC) experiments the melting processes of the proteins were calorimetrically irreversible, therefore the two-state kinetic model was used to evaluate the experiments. The results support the view that site-specific interaction of SH-containing proteins with hydroxyl and thiyl free radicals is able to modify the internal dynamics of proteins and affect the conformation of large molecules

Utilization of chemical abstracts service (CAS) data bases

International Nuclear Information System (INIS)

Ehrhardt, F.; Gesellschaft Deutscher Chemiker, Berlin

1979-04-01

A method is developed describing the economic utilization of the Chemical Abstracts Service data bases CA Condensates and Chemical Abstracts Subject Index Alertin order to supplement the data base of the IDC-Inorganica-Documentationsystem built up to meet the peculiarities of the inorganic chemistry. The method consists of EDP-Programs and processes at which special authority files for coded compound and subject entries play an important role. One of the advantages of the method is that the intellectual effort necessary to create such a data base is reduced to a minimum. The authority files may be also used for orther purposes. (orig.) 891 WB 892 MB [de

Knowledge and Utilization of the Partograph among obstetric care ...

African Journals Online (AJOL)

This cross-sectional study assessed knowledge and utilization of the partograph among health care workers in southwestern Nigeria. Respondents were selected by multi-stage sampling method from primary, secondary and tertiary levels of care. 719 respondents comprising of CHEWS - 110 (15.3%), Auxiliary Nurses - 148 ...

Structure and dynamics of spin-labeled insulin entrapped in a silica matrix by the sol-gel method.

Science.gov (United States)

Vanea, E; Gruian, C; Rickert, C; Steinhoff, H-J; Simon, V

2013-08-12

The structure and conformational dynamics of insulin entrapped into a silica matrix was monitored during the sol to maturated-gel transition by electron paramagnetic resonance (EPR) spectroscopy. Insulin was successfully spin-labeled with iodoacetamide and the bifunctional nitroxide reagent HO-1944. Room temperature continuous wave (cw) EPR spectra of insulin were recorded to assess the mobility of the attached spin labels. Insulin conformation and its distribution within the silica matrix were studied using double electron-electron resonance (DEER) and low-temperature cw-EPR. A porous oxide matrix seems to form around insulin molecules with pore diameters in the order of a few nanometers. Secondary structure of the encapsulated insulin investigated by Fourier transform infrared spectroscopy proved a high structural integrity of insulin even in the dried silica matrix. The results show that silica encapsulation can be used as a powerful tool to effectively isolate and functionally preserve biomolecules during preparation, storage, and release.

Integrating photovoltaics into utility distribution systems

International Nuclear Information System (INIS)

Zaininger, H.W.; Barnes, P.R.

1995-01-01

Electric utility distribution system impacts associated with the integration of distributed photovoltaic (PV) energy sources vary from site to site and utility to utility. The objective of this paper is to examine several utility- and site-specific conditions which may affect economic viability of distributed PV applications to utility systems. Assessment methodology compatible with technical and economic assessment techniques employed by utility engineers and planners is employed to determine PV benefits for seven different utility systems. The seven case studies are performed using utility system characteristics and assumptions obtained from appropriate utility personnel. The resulting site-specific distributed PV benefits increase nonsite-specific generation system benefits available to central station PV plants as much as 46%, for one utility located in the Southwest

A technology-assessment methodology for electric utility planning: With application to nuclear power plant decommissioning

International Nuclear Information System (INIS)

Lough, W.T.

1987-01-01

Electric utilities and public service commissions have not taken full advantage of the many proven methodologies and techniques available for evaluating complex technological issues. In addition, evaluations performed are deficient in their use of (1) methods for evaluating public attitudes and (2) formal methods of analysis for decision making. These oversight are substantiated through an examination of the literature relevant to electric utility planning. The assessment process known as technology assessment or TA is proposed, and a TA model is developed for route in use in utility planning by electric utilities and state regulatory commissions. Techniques to facilitate public participation and techniques to aid decision making are integral to the proposed model and are described in detail. Criteria are provided for selecting an appropriate technique on a case-by-case basis. The TA model proved to be an effective methodology for evaluating technological issues associated with electric utility planning such as decommissioning nuclear power plants. Through the use of the nominal group technique, the attitudes of a group of residential ratepayers were successfully identified and included in the decision-making process

Market research for electric utilities

International Nuclear Information System (INIS)

Shippee, G.

1999-01-01

Marketing research is increasing in importance as utilities become more marketing oriented. Marketing research managers need to maintain autonomy from the marketing director or ad agency and make sure their work is relevant to the utility's operation. This article will outline a model marketing research program for an electric utility. While a utility may not conduct each and every type of research described, the programs presented offer a smorgasbord of activities which successful electric utility marketers often use or have access to

VALUE-BASED MEDICINE AND OPHTHALMOLOGY: AN APPRAISAL OF COST-UTILITY ANALYSES

Science.gov (United States)

Brown, Gary C; Brown, Melissa M; Sharma, Sanjay; Brown, Heidi; Smithen, Lindsay; Leeser, David B; Beauchamp, George

2004-01-01

ABSTRACT Purpose To ascertain the extent to which ophthalmologic interventions have been evaluated in value-based medicine format. Methods Retrospective literature review. Papers in the healthcare literature utilizing cost-utility analysis were reviewed by researchers at the Center for Value-Based Medicine, Flourtown, Pennsylvania. A literature review of papers addressing the cost-utility analysis of ophthalmologic procedures in the United States over a 12-year period from 1992 to 2003 was undertaken using the National Library of Medicine and EMBASE databases. The cost-utility of ophthalmologic interventions in inflation-adjusted (real) year 2003 US dollars expended per quality-adjusted life-year ($/QALY) was ascertained in all instances. Results A total of 19 papers were found, including a total of 25 interventions. The median cost-utility of ophthalmologic interventions was $5,219/QALY, with a range from $746/QALY to $6.5 million/QALY. Conclusions The majority of ophthalmologic interventions are especially cost-effective by conventional standards. This is because of the substantial value that ophthalmologic interventions confer to patients with eye diseases for the resources expended. PMID:15747756

Barriers to adequate prenatal care utilization in American Samoa

Science.gov (United States)

Hawley, Nicola L; Brown, Carolyn; Nu’usolia, Ofeira; Ah-Ching, John; Muasau-Howard, Bethel; McGarvey, Stephen T

2013-01-01

Objective To describe the utilization of prenatal care in American Samoan women and to identify socio-demographic predictors of inadequate prenatal care utilization. Methods Using data from prenatal clinic records, women (n=692) were categorized according to the Adequacy of Prenatal Care Utilization Index as having received adequate plus, adequate, intermediate or inadequate prenatal care during their pregnancy. Categorical socio-demographic predictors of the timing of initiation of prenatal care (week of gestation) and the adequacy of received services were identified using one way Analysis of Variance (ANOVA) and independent samples t-tests. Results Between 2001 and 2008 85.4% of women received inadequate prenatal care. Parity (P=0.02), maternal unemployment (P=0.03), and both parents being unemployed (P=0.03) were negatively associated with the timing of prenatal care initation. Giving birth in 2007–2008, after a prenatal care incentive scheme had been introduced in the major hospital, was associated with earlier initiation of prenatal care (20.75 versus 25.12 weeks; Pprenatal care utilization in American Samoa is a major concern. Improving healthcare accessibility will be key in encouraging women to attend prenatal care. The significant improvements in the adequacy of prenatal care seen in 2007–2008 suggest that the prenatal care incentive program implemented in 2006 may be a very positive step toward addressing issues of prenatal care utilization in this population. PMID:24045912

Under stochastic dominance choquet-expected utility and anticipated utility are identical

NARCIS (Netherlands)

Wakker, P.P.

1990-01-01

The aim of this paper is to convince the reader that Choquet-expected utility, as initiated by Schmeidler (1982) for decision making under uncertainty, when formulated for decision making under risk naturally leads to Yaari (1987)'s anticipated utility. Thus the two generalizations of expected

Technology developments for Japanese BWR MOX fuel utilization

International Nuclear Information System (INIS)

Oguma, M.; Mochida, T.; Nomata, T.; Asahi, K.

1997-01-01

The Long-Term Program for Research, Development and Utilization of Nuclear Energy established by the Atomic Energy Commission of Japan asserts that Japan will promote systematic utilization of MOX fuel in LWRs. Based on this Japanese nuclear energy policy, we have been pushing development of MOX fuel technology aimed at future full scale utilization of this fuel in BWRs. In this paper, the main R and D topics are described from three subject areas, MOX core and fuel design, MOX fuel irradiation behaviour, and MOX fuel fabrication technology. For the first area, we explain the compatibility of MOX fuel with UO 2 core, the feasibility of the full MOX core, and the adaptability of MOX design methods based on a mock-up criticality experiment. In the second, we outline the Tsuruga MOX irradiation program and the DOMO program, and suggest that MOX fuel behaviour is comparable to ordinary BWR UO 2 fuel behaviour. In the third, we examine the development of a fully automated MOX bundle assembling apparatus and its features. (author). 14 refs, 11 figs, 3 tabs

Scalable fast multipole methods for vortex element methods