WorldWideScience

Sample records for methods development activities

  1. Development of methods for evaluating active faults

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The report for long-term evaluation of active faults was published by the Headquarters for Earthquake Research Promotion on Nov. 2010. After occurrence of the 2011 Tohoku-oki earthquake, the safety review guide with regard to geology and ground of site was revised by the Nuclear Safety Commission on Mar. 2012 with scientific knowledges of the earthquake. The Nuclear Regulation Authority established on Sep. 2012 is newly planning the New Safety Design Standard related to Earthquakes and Tsunamis of Light Water Nuclear Power Reactor Facilities. With respect to those guides and standards, our investigations for developing the methods of evaluating active faults are as follows; (1) For better evaluation on activities of offshore fault, we proposed a work flow to date marine terrace (indicator for offshore fault activity) during the last 400,000 years. We also developed the analysis of fault-related fold for evaluating of blind fault. (2) To clarify the activities of active faults without superstratum, we carried out the color analysis of fault gouge and divided the activities into thousand of years and tens of thousands. (3) To reduce uncertainties of fault activities and frequency of earthquakes, we compiled the survey data and possible errors. (4) For improving seismic hazard analysis, we compiled the fault activities of the Yunotake and Itozawa faults, induced by the 2011 Tohoku-oki earthquake. (author)

  2. Development of methods for evaluating active faults

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-08-15

    The HERP report for long-term evaluation of active faults and the NSC safety review guide with regard to geology and ground of site were published on Nov. 2010 and on Dec. 2010, respectively. With respect to those reports, our investigation is as follows; (1) For assessment of seismic hazard, we estimated seismic sources around NPPs based on information of tectonic geomorphology, earthquake distribution and subsurface geology. (2) For evaluation on the activity of blind fault, we calculated the slip rate on the 2008 Iwate-Miyagi Nairiku Earthquake fault, using information on late Quaternary fluvial terraces. (3) To evaluate the magnitude of earthquakes whose sources are difficult to identify, we proposed a new method for calculation of the seismogenic layer thickness. (4) To clarify the activities of active faults without superstratum, we carried out the color analysis of fault gouge and divided the activities into thousand of years and tens of thousands. (5) For improving chronology of sediments, we detected new widespread cryptotephras using mineral chemistry and developed late Quaternary cryptotephrostratigraphy around NPPs. (author)

  3. Development and simulation of various methods for neutron activation analysis

    International Nuclear Information System (INIS)

    Otgooloi, B.

    1993-01-01

    Simple methods for neutron activation analysis have been developed. The results on the studies of installation for determination of fluorine in fluorite ores directly on the lorry by fast neutron activation analysis have been shown. Nitrogen in organic materials was shown by N 14 and N 15 activation. The description of the new equipment 'FLUORITE' for fluorate factory have been shortly given. Pu and Be isotope in organic materials, including in wheat, was measured. 25 figs, 19 tabs. (Author, Translated by J.U)

  4. Methodical approaches to development of classification state methods of regulation business activity in fishery

    OpenAIRE

    She Son Gun

    2014-01-01

    Approaches to development of classification of the state methods of regulation of economy are considered. On the basis of the provided review the complex method of state regulation of business activity is reasonable. The offered principles allow improving public administration and can be used in industry concepts and state programs on support of small business in fishery.

  5. Developing an Assessment Method of Active Aging: University of Jyvaskyla Active Aging Scale.

    Science.gov (United States)

    Rantanen, Taina; Portegijs, Erja; Kokko, Katja; Rantakokko, Merja; Törmäkangas, Timo; Saajanaho, Milla

    2018-01-01

    To develop an assessment method of active aging for research on older people. A multiphase process that included drafting by an expert panel, a pilot study for item analysis and scale validity, a feedback study with focus groups and questionnaire respondents, and a test-retest study. Altogether 235 people aged 60 to 94 years provided responses and/or feedback. We developed a 17-item University of Jyvaskyla Active Aging Scale with four aspects in each item (goals, ability, opportunity, and activity; range 0-272). The psychometric and item properties are good and the scale assesses a unidimensional latent construct of active aging. Our scale assesses older people's striving for well-being through activities pertaining to their goals, abilities, and opportunities. The University of Jyvaskyla Active Aging Scale provides a quantifiable measure of active aging that may be used in postal questionnaires or interviews in research and practice.

  6. New developments in radiation protection instrumentation via active electronic methods

    International Nuclear Information System (INIS)

    Umbarger, C.J.

    1981-01-01

    New developments in electronics and radiation detectors are improving on real-time data acquisition of radiation exposure and contamination conditions. Recent developments in low power circuit designs, hybrid and integrated circuits, and microcomputers have all contributed to smaller and lighter radiation detection instruments that are, at the same time, more sensitive and provide more information (e.g., radioisotope identification) than previous devices. New developments in radiation detectors, such as cadmium telluride, gas scintillation proportional counters, and imaging counters (both charged particle and photon) promise higher sensitivities and expanded uses over present instruments. These developments are being applied in such areas as health physics, waste management, environmental monitoring, in vivo measurements, and nuclear safeguards

  7. Developments of a bonding technique for optical materials by a surface activation method

    International Nuclear Information System (INIS)

    Sugiyama, Akira; Oda, Tomohiro; Abe, Tomoyuki; Kusunoki, Isao

    2005-01-01

    We started developing the laser crystal bounding by the surface activation method which can splice crystals together without using hydrogen bonding. For the surface activation, neutral argon beams were used for irradiation of specimens. In the bonding trials with sapphire crystals, we recognized possibility of the bonding method for optical elements. (author)

  8. Development and validation of stability indicating UPLC assay method for ziprasidone active pharma ingredient

    Directory of Open Access Journals (Sweden)

    Sonam Mittal

    2012-01-01

    Full Text Available Background: Ziprasidone, a novel antipsychotic, exhibits a potent highly selective antagonistic activity on D2 and 5HT2A receptors. Literature survey for ziprasidone revealed several analytical methods based on different techniques but no UPLC method has been reported so far. Aim: Aim of this research paper is to present a simple and rapid stability indicating isocratic, ultra performance liquid chromatographic (UPLC method which was developed and validated for the determination of ziprasidone active pharmaceutical ingredient. Forced degradation studies of ziprasidone were studied under acid, base, oxidative hydrolysis, thermal stress and photo stress conditions. Materials and Methods: The quantitative determination of ziprasidone drug was performed on a Supelco analytical column (100×2.1 mm i.d., 2.7 ΅m with 10 mM ammonium acetate buffer (pH: 6.7 and acetonitrile (ACN as mobile phase with the ratio (55:45-Buffer:ACN at a flow rate of 0.35 ml/ min. For UPLC method, UV detection was made at 318 nm and the run time was 3 min. Developed UPLC method was validated as per ICH guidelines. Results and Conclusion: Mild degradation of the drug substance was observed during oxidative hydrolysis and considerable degradation observed during basic hydrolysis. During method validation, parameters such as precision, linearity, ruggedness, stability, robustness, and specificity were evaluated, which remained within acceptable limits. Developed UPLC method was successfully applied for evaluating assay of Ziprasidone active Pharma ingredient.

  9. DEVELOPMENT OF CREATIVE ACTIVITY OF STUDENTS AND IT’S METHODS IN THE FOREIGN PEDAGOGICS

    Directory of Open Access Journals (Sweden)

    Gajfutdinova Ajgul Rafkatovna

    2013-04-01

    Full Text Available Hope for the future of Russia are connected, first of all, with the preparation in the system of higher professional education of specialists, capable of active creative activity and self-realization in the complicated socio-cultural conditions. The concept of developing education dictates the necessity of the subjective position of the student in the learning process that requires development of his creative activity. The purpose of research: to develop the pedagogical conditions of development of creative activity of students in the process of learning a foreign language. The novelty of the study: Identified theoretical approaches of development of creative activity of the person, didactic features and functionality of developing technologies (brainstorming, sinektika, the method of «nominal group», the Delphi technique in the process of teaching a foreign language in a foreign education and opportunities for their use in the improvement of the national system of education. Criteria have been defined (motivational value: focus and interest in the subject matter; ability to self-organization, self-development and self-realization of creative plans; professional self-assertion and the manifestation of the personal sense of the student in a cross-cultural interaction and cognitive activity of students in mastering of educational material; manifestation of intellectual initiative, cognitive creativity, the development of creative thinking, search and research of mastering of educational material on the subject; operational activity: the development of creative abilities and skills; self-combination of well-known methods of the activity of the new, knowledge and skills to analyze and make conclusions, the acquisition of new knowledge and the experience of creative procedures (heuristic techniques, associative mechanisms, etc. and levels (low, medium, high of development of creative activity of students in the learning process. A foreign language

  10. DEVELOPMENT OF CREATIVE ACTIVITY OF STUDENTS AND IT’S METHODS IN THE FOREIGN PEDAGOGICS

    Directory of Open Access Journals (Sweden)

    Айгуль Рафкатовна Гайфутдинова

    2013-04-01

    Full Text Available Hope for the future of Russia are connected, first of all, with the preparation in the system of higher professional education of specialists, capable of active creative activity and self-realization in the complicated socio-cultural conditions. The concept of developing education dictates the necessity of the subjective position of the student in the learning process that requires development of his creative activity.The purpose of research: to develop the pedagogical conditions of development of creative activity of students in the process of learning a foreign language.The novelty of the study: Identified theoretical approaches of development of creative activity of the person, didactic features and functionality of developing technologies (brainstorming, sinektika, the method of «nominal group», theDelphitechnique in the process of teaching a foreign language in a foreign education and opportunities for their use in the improvement of the national system of education. Criteria have been defined (motivational value: focus and interest in the subject matter; ability to self-organization, self-development and self-realization of creative plans; professional self-assertion and the manifestation of the personal sense of the student in a cross-cultural interaction and cognitive activity of students in mastering of educational material; manifestation of intellectual initiative, cognitive creativity, the development of creative thinking, search and research of mastering of educational material on the subject; operational activity: the development of creative abilities and skills; self-combination of well-known methods of the activity of the new, knowledge and skills to analyze and make conclusions, the acquisition of new knowledge and the experience of creative procedures (heuristic techniques, associative mechanisms, etc. and levels (low, medium, high of development of creative activity of students in the learning process.A foreign language, with

  11. DEVELOPMENT OF ASSESSMENT METHODS OF EFFECTIVENESS OF INNOVATIVE STAFF ACTIVITY MOTIVATIONAL MECHANISM

    Directory of Open Access Journals (Sweden)

    Viktoriia Honchar

    2016-11-01

    Full Text Available The aim of the science work is to develop methods to assess the innovative activity of the personnel that will provide motivation for employees to be active in the direction of research and introduction of internal reserves for its improvement. Methods. In the study were used: system method and methods of logical analysis – to justify theoretical and practical recommendations on the development of conceptual bases of the formation of the motivational mechanism of personnel management, economic-mathematical modelling and forecasting methods – to assess the influence of motivation factors on the level of labour activity of the personnel. Results. In the work the notion “motivation”, considering the innovative changes of the modern economy, is clarified. In order to foster innovative activity in the enterprise it is proposed to improve organizational structure by controlling the center of innovation activity management, which includes economic, technical and social division. Proposed an establishment of the project teams under the terms of accounting costs, which contributes to more active workers’ involvement in the formation of innovative development plans. The main points that determine their effectiveness are: growth of volumes of output, diminution of expenses of materials and energy resources, timeliness and relevance to the product market, improvement of the quality of work performed. A profit, derived by project teams, is recommended to distribute on: increment of the payroll, innovative development, stimulation and motivation fund. The research of the activity of the enterprises showed that one of the effective methods to stimulate staff is a motivational system based on the use of KPI. Bonuses for the implemented project, which are adjusted to the output of the basic stage, or KPI project as a whole, fixed bonuses as a percentage of the profits, and bonuses in stages of the project are the forms of motivation of project teams

  12. Webcams, crowdsourcing, and enhanced crosswalks: Developing a novel method to analyze active transportation

    Directory of Open Access Journals (Sweden)

    J. Aaron eHipp

    2016-05-01

    Full Text Available Introduction: Active transportation opportunities and infrastructure are an important component of a community’s design, livability, and health. Features of the built environment influence active transportation, but objective study of the natural experiment effects of built environment improvements on active transportation is challenging. The purpose of this study was to develop and present a novel method of active transportation research using webcams and crowdsourcing, and to determine if crosswalk enhancement was associated with changes in active transportation rates, including across a variety of weather conditions. Methods: 20,529 publicly available webcam images from two street intersections in Washington, D.C., were used to examine the impact of an improved crosswalk on active transportation. A crowdsource, Amazon Mechanical Turk, annotated image data. Temperature data was collected from the National Oceanic and Atmospheric Administration, and precipitation data was annotated from images by trained research assistants. Results: Summary analyses demonstrated slight, bi-directional differences in the percent of images with pedestrians and bicyclists captured before and after the enhancement of the crosswalks. Chi-square analyses revealed these changes were not significant. In general, pedestrian presence increased in images captured during moderate temperatures compared to images captured during hot or cold temperatures. Chi-square analyses indicated the crosswalk improvement may have encouraged walking and biking in uncomfortable outdoor conditions (p<0.5. Conclusion: The methods employed provide an objective, cost-effective alternative to traditional means of examining the effects of built environment changes on active transportation. The use of webcams to collect active transportation data has applications for community policymakers, planners, and health professionals. Future research will work to validate this method in a variety of

  13. Development of low-activation design method for reduction of radioactive waste (4). Development of low-activation cement

    International Nuclear Information System (INIS)

    Ichitsubo, Koki; Tanosaki, Takao; Miura, Keiichi; Tomotake, Hiroichi; Yamada, Kazunori; Fujita, Hideki; Kinno, Masaharu; Hasegawa, Akira

    2008-01-01

    When nuclear plants will reach to decommission stage, a huge amount of concrete should be disposed as radioactive waste. To reduce the amount of radioactive concrete, the most effective methodology is not to use the materials of high radionuclide content such as coal ash and blast furnace slag, and to use limestone as additives or aggregate. However, concrete uses Portland cement for hardening, therefore, it is difficult to reduce the amount of radioactive concrete unless radionuclide content in cement is reduced. So in this study, we tried to develop the new type of Low-activation cement by reducing of radionuclide as europium and cobalt. As a result, we could reduce the amount of europium and cobalt in cement significantly, and obtained the result that the new cements can reduce radioactivity to one-third or less against commercially Portland cement in Japan. (author)

  14. Webcams, Crowdsourcing, and Enhanced Crosswalks: Developing a Novel Method to Analyze Active Transportation.

    Science.gov (United States)

    Hipp, J Aaron; Manteiga, Alicia; Burgess, Amanda; Stylianou, Abby; Pless, Robert

    2016-01-01

    Active transportation opportunities and infrastructure are an important component of a community's design, livability, and health. Features of the built environment influence active transportation, but objective study of the natural experiment effects of built environment improvements on active transportation is challenging. The purpose of this study was to develop and present a novel method of active transportation research using webcams and crowdsourcing, and to determine if crosswalk enhancement was associated with changes in active transportation rates, including across a variety of weather conditions. The 20,529 publicly available webcam images from two street intersections in Washington, DC, USA were used to examine the impact of an improved crosswalk on active transportation. A crowdsource, Amazon Mechanical Turk, annotated image data. Temperature data were collected from the National Oceanic and Atmospheric Administration, and precipitation data were annotated from images by trained research assistants. Summary analyses demonstrated slight, bi-directional differences in the percent of images with pedestrians and bicyclists captured before and after the enhancement of the crosswalks. Chi-square analyses revealed these changes were not significant. In general, pedestrian presence increased in images captured during moderate temperatures compared to images captured during hot or cold temperatures. Chi-square analyses indicated the crosswalk improvement may have encouraged walking and biking in uncomfortable outdoor conditions (P < 0.5). The methods employed provide an objective, cost-effective alternative to traditional means of examining the effects of built environment changes on active transportation. The use of webcams to collect active transportation data has applications for community policymakers, planners, and health professionals. Future research will work to validate this method in a variety of settings as well as across different built

  15. k{sub 0}-neutron activation analysis based method at CDTN: history, development and main achievements

    Energy Technology Data Exchange (ETDEWEB)

    Menezes, Maria Ângela de B.C.; Jacimovic, Radojko; Dalmazio, Ilza, E-mail: menezes@cdtn.br, E-mail: id@cdtn.br, E-mail: radojko.jacimovic@ijs.si [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte - MG (Brazil); Jožef Stefan Institute, Department of Environmental Sciences, Ljubljana (Slovenia)

    2017-11-01

    Neutron Activation Analysis (NAA) is an analytical technique to assay the elemental chemical composition in samples of several matrices. It has been applied by the Laboratory for Neutron Activation Analysis, located at Centro de Desenvolvimento da Tecnologia Nuclear (Nuclear Technology Development Centre) /Comissao Nacional de Energia Nuclear (Brazilian Commission for Nuclear Energy), CDTN/CNEN, since the starting up of the TRIGA MARK I IPR-R1 reactor, in 1960. Among the methods of this technique, the k{sub 0}-standardization method, which was established at CDTN in 1995, is the most efficient and in 2003 it was re-established and optimized. This paper is about the history and the main achievements since then. (author)

  16. Development of reconstitution method for surveillance specimens using surface activated joining

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Terumi; Kaihara, Shoichiro; Yoshida, Kazuo; Sato, Akira [Ishikawajima-Harima Heavy Industries Co. Ltd., Tokyo (Japan); Onizawa, Kunio; Nishiyama, Yutaka; Fukaya, Kiyoshi; Suzuki, Masahide

    1996-03-01

    Evaluation of embrittlement of reactor vessel steel due to irradiation requires surveillance tests. However, many surveillance specimens are necessary for nuclear plants life extension. Therefore, a specimen reconstitution technique has become important to provide the many specimens for continued surveillance. A surface activated joining (SAJ) method has been developed to join various materials together at low temperatures with little deformation, and is useful to bond irradiated specimens. To assess the validity of this method, Charpy impact tests were carried out, and the characteristics caused by heating during joining were measured. The test results showed the Charpy impact values were almost the same as base materials, and surface activated joining reduced heat affected zone to less than 2 mm. (author).

  17. k_0-neutron activation analysis based method at CDTN: history, development and main achievements

    International Nuclear Information System (INIS)

    Menezes, Maria Ângela de B.C.; Jacimovic, Radojko; Dalmazio, Ilza

    2017-01-01

    Neutron Activation Analysis (NAA) is an analytical technique to assay the elemental chemical composition in samples of several matrices. It has been applied by the Laboratory for Neutron Activation Analysis, located at Centro de Desenvolvimento da Tecnologia Nuclear (Nuclear Technology Development Centre) /Comissao Nacional de Energia Nuclear (Brazilian Commission for Nuclear Energy), CDTN/CNEN, since the starting up of the TRIGA MARK I IPR-R1 reactor, in 1960. Among the methods of this technique, the k_0-standardization method, which was established at CDTN in 1995, is the most efficient and in 2003 it was re-established and optimized. This paper is about the history and the main achievements since then. (author)

  18. Development of quench protection system for HTS coils by active power method

    International Nuclear Information System (INIS)

    Nanato, N.; Tsumiyama, Y.; Kim, S.B.; Murase, S.; Seong, K.-C.; Kim, H.-J.

    2007-01-01

    Recently, HTS coils have been developed for electric power apparatuses. In superconducting coils, local and excessive joule heating may give damage to the superconducting windings when a quench occurs and therefore it is essential that the quench is detected quickly and precisely so that the coils can be safely discharged. Resistive voltage measurement method is universally used for the quench detection, however, it is vulnerable to an electromagnetic noise which causes insufficient quench detection and at least needs a central voltage tap in windings. In a large superconducting coil, a lead-wire from the central voltage tap may cause a short-circuit when high voltage will be applied. In this paper, we present a quench protection system based on the active power method which detects a quench by measuring the instantaneous active power generated in a superconducting coil. The protection system based on this method is very strong against to the noise and no more needs a central voltage tap. The performance of system developed by us is confirmed by using test coil wound with Bi-2223 HTS tapes

  19. Development of active acoustic method for water leak detection of LMFBR steam generators

    International Nuclear Information System (INIS)

    Kumagai, Hiromichi; Yoshida, Kazuo; Kinoshita, Izumi

    2001-01-01

    In order to prevent the expansion of tube damage and to maintain structural integrity in the steam generators (SGs) of fast breeder reactors (FBRs), it is necessary to detect precisely and immediately the leakage of water from heat transfer tubes. Therefore, an active acoustic method, which detects the sound attenuation due to bubbles generated in the sodium-water reactions, is being developed. In this study, in order to evaluate the detection sensitivity of the active method, the signal processing methods for emitter and receiver and the detection method for leakage are investigated experimentally. In-water experiments performed by using an SG full-sector model that simulates the actual SGs. As an experimental result, the received sound attenuation for 10s was more than 10dB from air bubble injection when injected bubble of 10 l/s (equivalence water leak rate about 10 g/s.) The attenuation of sound are least affected by bubble injection position of heat transfer tubes bunch department. It is clarified that the background noise hardly influenced water leak detection performance as a result of having examined influence of background noise. (author)

  20. Methods of Strength Development in Boys of Primary School Age Using Active Games

    Directory of Open Access Journals (Sweden)

    С. І. Марченко

    2016-09-01

    Full Text Available The research objective is to analyze the effect of games on the dynamics of strength development in boys of the second-fourth grades. Research methods: theoretical analysis and collation of scientific and methodological literature, method of control testing, pedagogical experiment, methods of mathematical statistics. Research results. The paper addresses the feasibility of further scientific substantiation for the effect of the number of games, the number of repetitions, the intervals of rest and their interrelation on the change in the strength indicators for boys of primary school age. The study has revealed that strength development requires that the pupils of the second and the third grades perform four games, while the pupils of the fourth grade — five games. The number of repetitions for the pupils of the second grade is one and two, for the pupils of the third grade — two, and for the boys of the fourth grade — three, with 40-second intervals for rest. The most effective development manifests in the second and the fourth grades during 20 classes, and in the third grade —during 30 classes. After that, it is advisable to use other means. The game duration varies from two to five minutes. Conclusions. The results obtained during the experiment give reason to recommend that primary school teachers, coaches and parents use active games in physical education, sports training and individual motor activity of boys of primary school age. These games should aim at developing strength abilities, both purposefully and in complex with regard to the duration and pace (intensity of their performance.

  1. Development of low-activation design method for reduction of radioactive waste (3). Various types of low-activation concrete

    International Nuclear Information System (INIS)

    Kinno, Masaharu; Kimura, Ken-ichi; Fujikura, Yusuke

    2008-01-01

    Manufacturing tests by mixing together with low-activation aggregates, low-activation cements, low-activation additives, low-activation admixtures and low-activation neutron absorbers have been performed to develop low-activation concrete. After that, we developed various types (1/10, 1/20, 1/30, 1/50, 1/100, 1/300, 1/1,000, 1/3,000 and 1/10,000) of low-activation concrete composed of low-activation raw materials as very useful shielding material in a nuclear facility. The term '1/10 of low-activation concrete' denotes that the activity reduction rate to ordinary concrete is designed to be 1/10. By adopting some suitable types of low-activation concrete, most of the shielding concrete around ABWR and APWR are classified below clearance level on decommissioning. (author)

  2. Method Development of Cadmium Investigation in Rice by Radiochemical Neutron Activation Analysis

    International Nuclear Information System (INIS)

    Promsawad, Arunee; Pareepart, Ratirot; Laoharojanaphand, Sirinart; Arunee, Kongsakpaisal

    2007-08-01

    Full text: A radiochemical neutron activation analysis for the determination of cadmium was investigated. A chemical separation of cadmium utilized ion exchange chromatography of a strong basic anion-exchange resin BIO-RAD 1X 8 (Chloride form). The adsorbing medium of 2M HCl was found to be the most suitable among the concentration attempted (2, 4, 6, 8 and 10M HCl) and the eluent for desorption of the cadmium from column was 8M NH 3 solution. A chemical yield of 95% was found. The method has been evaluated by analyzing certified reference materials with 0.5.g/g (SRM 1577b, Bovine Liver) and 2.48.g/g (SRM 1566b, Oyster Tissue) cadmium. The agreement of the result with certified values is within 92% for Bovine Liver and 96% for Oyster Tissue. The method developed was applied to determine the cadmium concentrations in contaminated Thai rice. It was found that the cadmium concentrations ranged from 7.4 to 578.9 ppb

  3. Modelling of the activity system - development of an evaluation method for integrated system validation

    International Nuclear Information System (INIS)

    Norros, Leena; Savioja, Paula

    2004-01-01

    In this paper we present our recent research which focuses on creating an evaluation method for human-system interfaces of complex systems. The method is aimed for use in the validation of modernised nuclear power plant (NPP) control rooms, and other complex systems with high reliability requirements. The task in validation is to determine whether the human-system functions safely and effectively. This question can be operationalized to the selection of relevant operational features and their appropriate acceptance criteria. Thus, there is a need to ensure that the results of the evaluation can be generalized so that they serve the purpose of integrated system validation. The definition of the appropriate acceptance criteria provides basis for the judgement of the appropriateness of the performance of the system. We propose that the operational situations and the acceptance criteria should be defined based on modelling of the NPP operation that is comprehended as an activity system. We developed a new core-tasks modelling framework. It is a formative modelling approach that combines causal, functional and understanding explanations of system performance. In this paper we reason how modelling can be used as a medium to determine the validity of the emerging control room system. (Author)

  4. Developments of a bonding technique for optical materials by a surface activation method

    International Nuclear Information System (INIS)

    Sugiyama, Akira; Oda, Tomohiro; Abe, Tomoyuki; Kusunoki, Isao

    2007-01-01

    We have been developing a pair of sample holder used for optics in the surface activation bonding equipment. The holder can adjust the relative position of samples in the order of sub mm. To study the degree of dislocation appearing crystal surface activated by a fast atomic beam, irradiated sapphire crystals were examined by RBS, XPS, and AFM analysis. The heat treatment recovered the surface roughness of irradiated sapphire when the heating temperature reached at 1573 K. (author)

  5. METHODS AND MODELS FOR ANALYSIS OF THE ORGANIZATIONAL ECONOMICS ACTIVITY USED FOR DEVELOPMENT OF INFORMATICS SYSTEMS

    Directory of Open Access Journals (Sweden)

    TEODORA VĂTUIU

    2014-10-01

    Full Text Available Study of organizational activity and highlighting problem situations that require specific solutions, require a detailed analysis of the models defined for the real system of the economic companies, regarded not as a sum of assets, but as organizations in which there are activities related into processes. In addition to the usual approach of using modeling languages in the development of information systems, in this paper we intend to present some examples that demonstrate the usefulness of a standard modeling language (UML to analyze organizational activities and to report problem situations that may occur in data management registered on primary documents or in processes that bring together activities. Examples that have been focused on a travel agency can be extrapolated to any other organization, and the diagrams can be used in different contexts, depending on the complexity of the activities identified.

  6. The Physically Active Lifestyle of Flemish Secondary School Teachers: A Mixed-Methods Approach towards Developing a Physical Activity Intervention

    Science.gov (United States)

    Bogaert, Inge; De Martelaer, Kristine; Deforche, Benedicte; Clarys, Peter; Zinzen, Evert

    2015-01-01

    Objective: The primary aim of this study was to describe and analyse the physical activity and sedentary levels of secondary school teachers in Flanders. A secondary aim was to collect information regarding a possible worksite intervention of special relevance to secondary school teachers. Design: Mixed-methods quantitative and qualitative…

  7. Development of Quadratic Programming Algorithm Based on Interior Point Method with Estimation Mechanism of Active Constraints

    Science.gov (United States)

    Hashimoto, Hiroyuki; Takaguchi, Yusuke; Nakamura, Shizuka

    Instability of calculation process and increase of calculation time caused by increasing size of continuous optimization problem remain the major issues to be solved to apply the technique to practical industrial systems. This paper proposes an enhanced quadratic programming algorithm based on interior point method mainly for improvement of calculation stability. The proposed method has dynamic estimation mechanism of active constraints on variables, which fixes the variables getting closer to the upper/lower limit on them and afterwards releases the fixed ones as needed during the optimization process. It is considered as algorithm-level integration of the solution strategy of active-set method into the interior point method framework. We describe some numerical results on commonly-used bench-mark problems called “CUTEr” to show the effectiveness of the proposed method. Furthermore, the test results on large-sized ELD problem (Economic Load Dispatching problems in electric power supply scheduling) are also described as a practical industrial application.

  8. Principles and methods of neutron activation analysis (NAA) in improved water resources development

    International Nuclear Information System (INIS)

    Dim, L. A.

    2000-01-01

    The methods of neutron activation analysis (NAA) as it applies to water resources exploration, exploitation and management has been reviewed and its capabilities demonstrated. NAA has been found to be superior and offer higher sensitivity to many other analytical techniques in analysis of water. The implications of chemical and element concentrations (water pollution and quality) determined in water on environmental impact assessment to aquatic life and human health are briefly highlighted

  9. ASTM and VAMAS activities in titanium matrix composites test methods development

    Science.gov (United States)

    Johnson, W. S.; Harmon, D. M.; Bartolotta, P. A.; Russ, S. M.

    1994-01-01

    Titanium matrix composites (TMC's) are being considered for a number of aerospace applications ranging from high performance engine components to airframe structures in areas that require high stiffness to weight ratios at temperatures up to 400 C. TMC's exhibit unique mechanical behavior due to fiber-matrix interface failures, matrix cracks bridged by fibers, thermo-viscoplastic behavior of the matrix at elevated temperatures, and the development of significant thermal residual stresses in the composite due to fabrication. Standard testing methodology must be developed to reflect the uniqueness of this type of material systems. The purpose of this paper is to review the current activities in ASTM and Versailles Project on Advanced Materials and Standards (VAMAS) that are directed toward the development of standard test methodology for titanium matrix composites.

  10. The development of method of recultivating landscapes which have been disturbed by industrial activity

    Energy Technology Data Exchange (ETDEWEB)

    Verner, K

    1979-01-01

    Difficulties, which appear with the combined investigation of the Comecon member states concerning the problems of preserving the environment with the introduction of mining operations (the need for various terms, the differences in methods of investigation, and so forth), are examined here. As a result of an analysis of that problem, a six-language terminological dictionary on the recultivation of landscapes was developed, and a ''Catalog of unified methods of analysis'' was published. Besides this, works on the classification of broken off ground, based on the data from the named catalog, being carried out by the exchange of the suppositions and notions of the international work group under the direction of Polish associates, are reaching completion. Three key problems along with some associated problems are being put forward for 1981 to 1985. These are described in the text.

  11. Development of analytical methods for the determination of some radiologically important elements in biological materials using neutron activation analysis

    International Nuclear Information System (INIS)

    Dang, H.S.; Jaiswal, D.D.; Pullat, V.R.; Krishnamony, S.

    1998-01-01

    This paper describes the analytical methods developed for the estimation of Cs, I, Sr, Th and U in biological materials such as food and human tissues. The methods employ both, the instrumental neutron activation analysis (INAA) and radiochemical neutron activation analysis (RNAA). The adequacy of these methods to determine the concentrations of the above elements in dietary and tissue materials was also studied. The study showed that the analytical methods described in this paper are adequate for the determination of Cs, Sr, Th and U in all kinds of biological samples. In the case of I however, the method is adequate only for determining its concentration in thyroid, but needs to be modified to improve its sensitivity for the determination of I in diet samples. (author)

  12. Development of distinction method of production area of ginsengs by using a neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngjin; Chung, Yongsam; Sim, Chulmuu; Sun, Gwangmin; Lee, Yuna; Yoo, Sangho

    2011-01-15

    During the last 2 years of the project, we have tried to develop the technology to make a distinction of the production areas for Korean ginsengs cultivated in the various provinces in Korea and foreign countries. It will contribute to secure the health food safety for public and stability of its market. In this year, we collected ginseng samples cultivated in the northeastern province in Chinese mainland such as Liaoning province, Jilin province and Baekdu mountain within Jilin province. 10 ginseng samples were collected at each province. The elemental concentrations in the ginseng were analyzed by using a neutron activation analysis technique at the HANARO research reactor. The distinction of production area was made by using a statistical software. As a result, the Chinese Korean ginsengs were certainly differentiated from those cultivated in the famous province in Korea though there was a limitation that the number of our sample we analyzed is very small.

  13. Development of distinction method of production area of ginsengs by using a neutron activation analysis

    International Nuclear Information System (INIS)

    Kim, Youngjin; Chung, Yongsam; Sim, Chulmuu; Sun, Gwangmin; Lee, Yuna; Yoo, Sangho

    2011-01-01

    During the last 2 years of the project, we have tried to develop the technology to make a distinction of the production areas for Korean ginsengs cultivated in the various provinces in Korea and foreign countries. It will contribute to secure the health food safety for public and stability of its market. In this year, we collected ginseng samples cultivated in the northeastern province in Chinese mainland such as Liaoning province, Jilin province and Baekdu mountain within Jilin province. 10 ginseng samples were collected at each province. The elemental concentrations in the ginseng were analyzed by using a neutron activation analysis technique at the HANARO research reactor. The distinction of production area was made by using a statistical software. As a result, the Chinese Korean ginsengs were certainly differentiated from those cultivated in the famous province in Korea though there was a limitation that the number of our sample we analyzed is very small

  14. Effect of roscovitine treated donor cells and different activation methods on development of handmade cloned goat (Capra hircus) embryos.

    Science.gov (United States)

    Akshey, Y S; Malakar, D; De, A Kumar; Jena, M Kumar; Pawar, S Kumar; Dutta, R; Sahu, S

    2011-05-01

    The aim of the present investigation was to find out the effects of roscovitine treatment of donor cells and different activation methods on development of HMC goat embryos. Goat fetal fibroblast cells were cultured and divided into three treatment groups-contact inhibition group, roscovitine treatment group and serum starvation group. There was a significant decrease in blastocyst yield in serum starvation group (6.82%) compared to roscovitine treatment group (19.31%) and contact inhibition group (18.52%), however, no significant difference was found between roscovitine treatment group and contact inhibition group. To see the effect of different methods of activation, the reconstructed embryos were randomly divided into two groups and activated by two methods-one half by 2 μM Ca ionophore and another half by 2.31 kV/cm for 15 μSec electrical pulse. Subsequently, cloned embryos were cultured in TCM-199 based embryo development medium supplemented with 10 mg/mL bovine serum albumin in WOW culture system. There was a significant increase in the rate of cleavage and blastocyst production in electric pulse activation of 78.57% and 21.43% than Ca ionophore activation of 62.63% and 10.61% respectively. In conclusion, treatment of donor cells with roscovitine yields a significantly increased blastocyst than serum starved donor cells but equivalent blastocyst to contact inhibition group and electrical pulse activation (EPA) improves the production of HMC goat embryos. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Development of an original active thermography method adapted to ITER plasma facing components control

    Energy Technology Data Exchange (ETDEWEB)

    Durocher, A.; Vignal, N.; Escourbiac, F.; Farjon, J.L.; Schlosser, J. [CEA Cadarache, Dept. de Recherches sur la Fusion Controlee, 13 - Saint-Paul-lez-Durance (France); Cismondi, F. [Toulon Univ., 83 - La Garde (France)

    2004-07-01

    Among all Non-Destructive Examinations (NDE), active infrared thermography is becoming recognised as a technique available today for improving quality control of many materials and structures involved in heat transfer. The infrared thermography allows to characterise the bond between two materials having different thermal physical properties. In order to increase the defect detection limit of the SATIR test bed, several possibilities have been evaluated to improve the infrared thermography inspection. The implementation in 2003 of a micro-bolometer camera and the improving of the thermo-signal process allowed to increase considerably the detection sensitivity of the SATIR facility. The quality, the spatial stability of infrared image and the detection of edge defect have been also improved. The coupling on the same test bed of SATIR method with a lock-in thermography will be evaluated in this paper. An improvement of the global reliability is expected by data merging produced by the two thermal excitation sources. A new enhanced facility named SATIRPACA has been designed for the full Non Destructive Examination of the High Heat Flux ITER components taking into account these main improvements. These systematic acceptance tests obviously need tools for quality control of critical parts. (authors)

  16. Development of an original active thermography method adapted to ITER plasma facing components control

    International Nuclear Information System (INIS)

    Durocher, A.; Vignal, N.; Escourbiac, F.; Farjon, J.L.; Schlosser, J.; Cismondi, F.

    2004-01-01

    Among all Non-Destructive Examinations (NDE), active infrared thermography is becoming recognised as a technique available today for improving quality control of many materials and structures involved in heat transfer. The infrared thermography allows to characterise the bond between two materials having different thermal physical properties. In order to increase the defect detection limit of the SATIR test bed, several possibilities have been evaluated to improve the infrared thermography inspection. The implementation in 2003 of a micro-bolometer camera and the improving of the thermo-signal process allowed to increase considerably the detection sensitivity of the SATIR facility. The quality, the spatial stability of infrared image and the detection of edge defect have been also improved. The coupling on the same test bed of SATIR method with a lock-in thermography will be evaluated in this paper. An improvement of the global reliability is expected by data merging produced by the two thermal excitation sources. A new enhanced facility named SATIRPACA has been designed for the full Non Destructive Examination of the High Heat Flux ITER components taking into account these main improvements. These systematic acceptance tests obviously need tools for quality control of critical parts. (authors)

  17. A development and integration of the concentration database for relative method, k0 method and absolute method in instrumental neutron activation analysis using Microsoft Access

    International Nuclear Information System (INIS)

    Hoh Siew Sin

    2012-01-01

    Instrumental Neutron Activation Analysis (INAA) is offen used to determine and calculate the concentration of an element in the sample by the National University of Malaysia, especially students of Nuclear Science Program. The lack of a database service leads consumers to take longer time to calculate the concentration of an element in the sample. This is because we are more dependent on software that is developed by foreign researchers which are costly. To overcome this problem, a study has been carried out to build an INAA database software. The objective of this study is to build a database software that help the users of INAA in Relative Method and Absolute Method for calculating the element concentration in the sample using Microsoft Excel 2010 and Microsoft Access 2010. The study also integrates k 0 data, k 0 Concent and k 0 -Westcott to execute and complete the system. After the integration, a study was conducted to test the effectiveness of the database software by comparing the concentrations between the experiments and in the database. Triple Bare Monitor Zr-Au and Cr-Mo-Au were used in Abs-INAA as monitor to determine the thermal to epithermal neutron flux ratio (f). Calculations involved in determining the concentration are the net peak area (N p ), the measurement time (t m ), the irradiation time (t irr ), k-factor (k), thermal to epithermal neutron flux ratio (f), the parameters of the neutron flux distribution epithermal (α) and detection efficiency (ε p ). For Com-INAA databases, reference material IAEA-375 Soil was used to calculate the concentration of elements in the sample. CRM, SRM are also used in this database. After the INAA database integration, a verification process was to examine the effectiveness of the Abs-INAA was carried out by comparing the sample concentration between the in database and the experiment. The result of the experimental concentration value of INAA database software performed with high accuracy and precision. ICC

  18. Development of Distinction Method of Production Area of Ginsengs by Using a Neutron Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chung, Yong Sam; Sun, Gwang Min; Lee, Yu Na; Yoo, Sang Ho [KAERI, Daejeon (Korea, Republic of)

    2010-05-15

    Distinction of production area of Korean ginsengs has been tried by using neutron activation techniques such as an instrumental neutron activation analysis (INAA) and a prompt gamma activation analysis (PGAA). A distribution of elements has varied according to the part of plant clue to the difference of enrichment effect and influence from a soil where the plants have been grown. So correlation study between plants and soil has been an Issue. In this study, the distribution of trace elements within a Korean ginseng was investigated by using an instrumental neutron activation analysis

  19. THE METHOD OF APPLICATION OF A COLLECTIVE SEARCH ACTIVITY AS A TOOL DEVELOPING METHODOLOGICAL THINKING OF A TEACHER

    Directory of Open Access Journals (Sweden)

    Ibragimova Luiza Vahaevna

    2013-02-01

    Full Text Available To realize any pedagogical theory into practice it is necessary to transform the theoretical concepts in teaching methods. The development of all abilities, including thinking, occurs only in the activity, which is specially organized by creating the required pedagogical conditions, in this case – it is a the application of enhanced mental activity in teachers training course and vocational training b establishment of a "virtual university" for teachers in an institute of professional training c the organization of interdisciplinary interaction of teachers, based on conditions of the nonlinear didactics (training teachers of different subjects. The presented method is implemented for two years and consists of three phases: the motivational and educational, intellectual and developmental, innovative and reflective. At the motivational and educational stage, possibilities of collective search activity actualize during the course of training, group goals are set and chosen methods of their achieving by using the first pedagogical conditions. At intellectual and developmental stage, the development of skills to the collective search for effective teaching decisions during intercourse training with the first-and second-pedagogical conditions is carried out. The innovative step is the promotion of teachers to self-determination of techniques and tools that improve the quality of the educational process, providing assistance to each other in the development of teaching manuals, which is achieved with the help of all three pedagogical conditions.

  20. THE METHOD OF APPLICATION OF A COLLECTIVE SEARCH ACTIVITY AS A TOOL DEVELOPING METHODOLOGICAL THINKING OF A TEACHER

    Directory of Open Access Journals (Sweden)

    Луиза Вахаевна Ибрагимова

    2013-04-01

    Full Text Available To realize any pedagogical theory into practice it is necessary to transform the theoretical concepts in teaching methods. The development of all abilities, including thinking, occurs only in the activity, which is specially organized by creating the required pedagogical conditions, in this case – it is a the application of enhanced mental activity in teachers training course and vocational training b establishment of a "virtual university" for teachers in an institute of professional training c the organization of interdisciplinary interaction of teachers, based on conditions of the nonlinear didactics (training teachers of different subjects. The presented method is implemented for two years and consists of three phases: the motivational and educational, intellectual and developmental, innovative and reflective. At the motivational and educational stage, possibilities of collective search activity actualize during the course of training, group goals are set and chosen methods of their achieving by using the first pedagogical conditions. At intellectual and developmental stage, the development of skills to the collective search for effective teaching decisions during intercourse training with the first-and second-pedagogical conditions is carried out. The innovative step is the promotion of teachers to self-determination of techniques and tools that improve the quality of the educational process, providing assistance to each other in the development of teaching manuals, which is achieved with the help of all three pedagogical conditions.DOI: http://dx.doi.org/10.12731/2218-7405-2013-2-17

  1. Development of concepts of plants activity, its ecological role and methods of its assessment in ecosystems

    Directory of Open Access Journals (Sweden)

    Savinov Alexander

    2017-09-01

    Full Text Available When studying the species activity in the phytocoenoses, three methodological approaches are used: coenotipic, status and ergontic. The latter is proposed for the first time and based on the fact that the activity of plant organisms of a given species is considered as a set of interactions of these organisms with each other, with other organisms and abiotic components of ecosystems. This interaction essentially reflects the rate of accumulation and generation of substances, energy and information by plant organisms. To calculate the activity of the plant species in this aspect, the appropriate formulas were proposed. When comparing the coenotipic, status and ergontic approaches, it was stated that these approaches can complement each other.

  2. Active methodologies in Financial Management classes: an alternative to the traditional teaching method for awakening intrinsic motivation and developing autonomy

    Directory of Open Access Journals (Sweden)

    Guilherme Muniz Pereira Chaves Urias

    2017-01-01

    Full Text Available This article presents a pedagogical experience in Financial Management classes. The objective of this study was to investigate whether the educational activity based on active methodologies, applied in the Financial Management classes in an undergraduate course in Business Administration, can offer formative spaces that enhance the development of the students’ intrinsic motivation to the point of being relevant to the development of their autonomy and thus to be characterized as a viable manner of putting the Freirean pedagogy into practice. In order to do so, the adopted teaching strategy aimed at creating opportunities for interpretating problems that simulated real situations. A questionnaire was applied and the Bardinian content analysis was used to verify the students' impressions about the activity itself and its respective contribution to their professional and personal training. The analysis points to the fact that active methodologies are viable alternatives to the traditional method of teaching regarding the awakening of interest, motivation and the development of learning. It also points to their consonance with the Freirian pedagogy.

  3. Cooperative method development

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; Rönkkö, Kari; Eriksson, Jeanette

    2008-01-01

    The development of methods tools and process improvements is best to be based on the understanding of the development practice to be supported. Qualitative research has been proposed as a method for understanding the social and cooperative aspects of software development. However, qualitative...... research is not easily combined with the improvement orientation of an engineering discipline. During the last 6 years, we have applied an approach we call `cooperative method development', which combines qualitative social science fieldwork, with problem-oriented method, technique and process improvement....... The action research based approach focusing on shop floor software development practices allows an understanding of how contextual contingencies influence the deployment and applicability of methods, processes and techniques. This article summarizes the experiences and discusses the further development...

  4. Method Development for the Analysis of Pharmaceuticals with Acethylcholinesterase Activity in Water Using HPLC-DAD and Solid Phase Extraction

    Directory of Open Access Journals (Sweden)

    Samuel Budi Wardhana

    2014-03-01

    Full Text Available An SPE followed by HPLC-DAD method with ion pair chromatography technique to analyze pharmaceuticals with acethylcholinesterase activity including pyridostigmine (PYR, galathamine (GAL, neostigmine (NEO, eserine (ESE, and donepezil (DON in water samples was developed. Acetylcholinesterase (AChE inhibitors have been used to treat less severe dementias such as Alzheimer’s disease. Chromatographic separation was achieved using reversed-phase SymmetryShield column using gradient system with mobile phase consisting of H2O/ACN (99:1, v/v as mobile phase A with 10 mM sodium 1-hexanesulfonate and 0.1% acetic acid (HAc. The HPLC/DAD method was linear between concentrations of 5 to 100 ng/μL. The IDL and IQL ranged from 0.50 to 1.25 ng/μL and 1.5 to 3.0 ng/μL, respectively. SPE was used to extract and clean up the target substances in spiked pure water, tap water, and wastewater samples. The application of extraction method of 5 target substances in wastewater sample was divided into 2 parts: Oasis WCX (6 mL, 500 mg for PYR and Oasis HLB (6 mL, 200 mg for GAL, NEO, ESE and DON. The developed SPE and HPLC/DAD method is applicable for quantification of the 5 target substances in water samples in a concentration range > 50 µg/L and assumable lower for DON (> 25 µg/L.

  5. Developing a method for the retrospective estimation of radon exposure from in vivo measurements of 210Pb activity in bone

    International Nuclear Information System (INIS)

    McKenzie, R.J.; Johnston, P.N.

    1999-01-01

    Radon is a naturally occurring radioactive gas which has been linked to lung cancer in occupationally exposed uranium mine workers. Where monitoring of an individual's exposure to radon and radon progeny has not occurred or is incomplete, it may be possible to determine this exposure retrospectively by the measurement of the long lived decay product 210 Pb which accumulates in the bones of exposed individuals. This paper describes a method being developed at the whole body monitor (WBM) facility of the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) to estimate the time integrated exposure to radon over a period of up to several decades from the in vivo measurements of 210 Pb activity in the knee of human subjects. Initial work has concentrated on characterising the WBM facility for this work using artificial bone phantoms. This project will serve as a test of the feasibility of the method before undertaking further studies on human subjects

  6. Developing a capillary electrophoresis based method for dynamically monitoring enzyme cleavage activity using quantum dots-peptide assembly.

    Science.gov (United States)

    Wang, Jianhao; Fan, Jie; Liu, Li; Ding, Shumin; Liu, Xiaoqian; Wang, Jianpeng; Gao, Liqian; Chattopadhaya, Souvik; Miao, Peng; Xia, Jiang; Qiu, Lin; Jiang, Pengju

    2017-10-01

    Herein, a novel assay has been developed for monitoring PreScission protease (His-PSP) mediated enzyme cleavage of ATTO 590 labeled peptide substrate (ATTO-LEV). This novel method is based on combining the use of capillary electrophoresis and fluorescence detection (CE-FL) to dynamically monitor the enzyme cleavage activity. A multivalent peptide substrate was first constructed by immobilizing His-tagged ATTO 590 labeled peptide substrate (ATTO-LEVH6) onto the surface of CdSe/ZnS quantum dots (QDs). Once successfully immobilized, the novel multivalent peptide substrate resulted in the Förster resonance energy transfer (FRET) from QDs to ATTO 590. The ATTO-LEVH6-QD assembly was then incubated with His-PSP to study the proteolytic cleavage of surface bound ATTO-LEVH6 by CE-FL. Our data suggests that PreScission-mediated proteolytic cleavage is enzyme concentration- and incubation time-dependent. By combining capillary electrophoresis, QDs and FRET, our study herein not only provides a new method for the detection and dynamically monitoring of PSP enzyme cleavage activity, but also can be extended to the detection of many other enzymes and proteases. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Development of analytical methods for the determination of trace elements in sediment with Neutron ActivAtion method (NAA) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

    International Nuclear Information System (INIS)

    Nam, Sang Ho; Kim, Jae Jin; Chung, Yong Sam; Kim, Sun Ha

    2005-01-01

    The analytical methods for the determination of major elements (Al, Ca, K, Fe, Mg) in sediment have been investigated with ICP-MS. The analytical results of major elements with Cool ICP-MS were much better than those with normal ICP-MS. The analytical results were compared with those of NAA. NAA were a little superior to ICP-MS for the determination of major elements in sediment, and NAA is a non-destructive analytical method. The analytical methods for the determination of minor elements (Cr, Ce, U, Co, Pb, As, Se) in sediment have been also studied with ICP-MS. The analytical results by standard calibration with ICP-MS were not accurate due to matrix interferences. Thus, internal standard method was applied, then the analytical results for minor element with ICP-MS were greatly improved. The analytical results obtained by ICP-MS were compared with those obtained by NAA. It showed that the two analytical methods have great capabilities for the determination of minor elements in sediments

  8. Development of a physical activity monitoring tool for Thai medical schools: a protocol for a mixed methods study

    Science.gov (United States)

    Wattanapisit, Apichai; Vijitpongjinda, Surasak; Saengow, Udomsak; Amaek, Waluka; Thanamee, Sanhapan; Petchuay, Prachyapan

    2017-01-01

    Introduction Physical activity (PA) is important in promoting health, as well as in the treatment and prevention of diseases. However, insufficient PA is still a global health problem and it is also a problem in medical schools. PA training in medical curricula is still sparse or non-existent. There is a need for a comprehensive understanding of the extent of PA in medical schools through several indicators, including people, places and policies. This study includes a survey of the PA prevalence in a medical school and development of a tool, the Medical School Physical Activity Report Card (MSPARC), which will contain concise and understandable infographics and information for exploring, monitoring and reporting information relating to PA prevalence. Methods and analysis This mixed methods study will run from January to September 2017. We will involve the School of Medicine, Walailak University, Thailand, and its medical students (n=285). Data collection will consist of both primary and secondary data, divided into four parts: general information, people, places and policies. We will investigate the PA metrics about (1) people: the prevalence of PA and sedentary behaviours; (2) place: the quality and accessibility of walkable neighbourhoods, bicycle facilities and recreational areas; and (3) policy: PA promotion programmes for medical students, education metrics and investments related to PA. The MSPARC will be developed using simple symbols, infographics and short texts to evaluate the PA metrics of the medical school. Ethics and dissemination This study has been approved by the Human Research Ethics Committee of Walailak University (protocol number: WUEC-16-005-01). Findings will be published in peer-reviewed journals and presented at national or international conferences. The MSPARC and full report will be disseminated to relevant stakeholders, policymakers, staff and clients. PMID:28963299

  9. Automatic Earthquake Shear Stress Measurement Method Developed for Accurate Time- Prediction Analysis of Forthcoming Major Earthquakes Along Shallow Active Faults

    Science.gov (United States)

    Serata, S.

    2006-12-01

    The Serata Stressmeter has been developed to measure and monitor earthquake shear stress build-up along shallow active faults. The development work made in the past 25 years has established the Stressmeter as an automatic stress measurement system to study timing of forthcoming major earthquakes in support of the current earthquake prediction studies based on statistical analysis of seismological observations. In early 1982, a series of major Man-made earthquakes (magnitude 4.5-5.0) suddenly occurred in an area over deep underground potash mine in Saskatchewan, Canada. By measuring underground stress condition of the mine, the direct cause of the earthquake was disclosed. The cause was successfully eliminated by controlling the stress condition of the mine. The Japanese government was interested in this development and the Stressmeter was introduced to the Japanese government research program for earthquake stress studies. In Japan the Stressmeter was first utilized for direct measurement of the intrinsic lateral tectonic stress gradient G. The measurement, conducted at the Mt. Fuji Underground Research Center of the Japanese government, disclosed the constant natural gradients of maximum and minimum lateral stresses in an excellent agreement with the theoretical value, i.e., G = 0.25. All the conventional methods of overcoring, hydrofracturing and deformation, which were introduced to compete with the Serata method, failed demonstrating the fundamental difficulties of the conventional methods. The intrinsic lateral stress gradient determined by the Stressmeter for the Japanese government was found to be the same with all the other measurements made by the Stressmeter in Japan. The stress measurement results obtained by the major international stress measurement work in the Hot Dry Rock Projects conducted in USA, England and Germany are found to be in good agreement with the Stressmeter results obtained in Japan. Based on this broad agreement, a solid geomechanical

  10. GEM simulation methods development

    International Nuclear Information System (INIS)

    Tikhonov, V.; Veenhof, R.

    2002-01-01

    A review of methods used in the simulation of processes in gas electron multipliers (GEMs) and in the accurate calculation of detector characteristics is presented. Such detector characteristics as effective gas gain, transparency, charge collection and losses have been calculated and optimized for a number of GEM geometries and compared with experiment. A method and a new special program for calculations of detector macro-characteristics such as signal response in a real detector readout structure, and spatial and time resolution of detectors have been developed and used for detector optimization. A detailed development of signal induction on readout electrodes and electronics characteristics are included in the new program. A method for the simulation of charging-up effects in GEM detectors is described. All methods show good agreement with experiment

  11. CDBG Economic Development Activity

    Data.gov (United States)

    Department of Housing and Urban Development — CDBG activity related to economic development, including commercial or industrial rehab, commercial or industrial land acquisition, commercial or industrial...

  12. Radiolabeled monoclonal antibodies. Development of a new method to remove circulating activity - diagnostic applications and implications for therapy

    International Nuclear Information System (INIS)

    Norrgren, K.

    1993-04-01

    The aim of this thesis was to develop and investigate the usefulness of extracorporeal immunoadsorption (ECIA) to remove circulating activity after the localization of radiolabeled monoclonal antibodies to tumors. A compartment model, based on the biokinetics of 125 I-labeled antibodies 96.5 was developed to estimate the effect of ECIA on the tumor-to-normal tissue ratios. ECIA was simulated at different times after injection of the antibodies and the calculations showed an increased diagnostic ratio for several hours after the ECIA procedure, and that an enhancement of the therapeutic ratio was possible. These results led to the development of animal models where the ECIA could be evaluated and the biokinetic behaviour of different radiolabeled monoclonal antibodies investigated with and without the application of ECIA. A general ECIA method, based on biotinylated antibodies and an avidin agarose column as adsorbent, was developed. Studies in tumor bearing nude rats showed that ECIA enhanced of the tumor-to-normal tissue activity ratios by a factor of 4 for the liver, kidneys and bone marrow. For the L6 antibody, the image contrast of tumors localized in one kidney of the rats, was increased from 1.1 to 1.6. A software anthropomorphic phantom was used in Monte Carlo simulations of clinically realistic scintillation camera image acquisition. The effect of ECIA on the contrast enhancement and on the detectability of simulated tumors located centrally in the liver was studied. The contrast increased linearly with an increasing tumor/liver ratio. The contrast was higher for SPECT than for planar images and a contrast of 1.15 required a tumor/liver activity ratio of 1.9 for SPECT and 4.5 for planar images. ECIA in combination with SPECT imaging of radiolabeled antibodies has a great potential in increasing the detectability of tumors. These studies have shown the possibility with ECIA to increase the contrast in radioimmunoimaging and to enhance the therapeutic ratio

  13. Development of a physical activity monitoring tool for Thai medical schools: a protocol for a mixed methods study.

    Science.gov (United States)

    Wattanapisit, Apichai; Vijitpongjinda, Surasak; Saengow, Udomsak; Amaek, Waluka; Thanamee, Sanhapan; Petchuay, Prachyapan

    2017-09-27

    Physical activity (PA) is important in promoting health, as well as in the treatment and prevention of diseases. However, insufficient PA is still a global health problem and it is also a problem in medical schools. PA training in medical curricula is still sparse or non-existent. There is a need for a comprehensive understanding of the extent of PA in medical schools through several indicators, including people, places and policies. This study includes a survey of the PA prevalence in a medical school and development of a tool, the Medical School Physical Activity Report Card (MSPARC), which will contain concise and understandable infographics and information for exploring, monitoring and reporting information relating to PA prevalence. This mixed methods study will run from January to September 2017. We will involve the School of Medicine, Walailak University, Thailand, and its medical students (n=285). Data collection will consist of both primary and secondary data, divided into four parts: general information, people, places and policies. We will investigate the PA metrics about (1) people: the prevalence of PA and sedentary behaviours; (2) place: the quality and accessibility of walkable neighbourhoods, bicycle facilities and recreational areas; and (3) policy: PA promotion programmes for medical students, education metrics and investments related to PA. The MSPARC will be developed using simple symbols, infographics and short texts to evaluate the PA metrics of the medical school. This study has been approved by the Human Research Ethics Committee of Walailak University (protocol number: WUEC-16-005-01). Findings will be published in peer-reviewed journals and presented at national or international conferences. The MSPARC and full report will be disseminated to relevant stakeholders, policymakers, staff and clients. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is

  14. Feature-Free Activity Classification of Inertial Sensor Data With Machine Vision Techniques: Method, Development, and Evaluation.

    Science.gov (United States)

    Dominguez Veiga, Jose Juan; O'Reilly, Martin; Whelan, Darragh; Caulfield, Brian; Ward, Tomas E

    2017-08-04

    Inertial sensors are one of the most commonly used sources of data for human activity recognition (HAR) and exercise detection (ED) tasks. The time series produced by these sensors are generally analyzed through numerical methods. Machine learning techniques such as random forests or support vector machines are popular in this field for classification efforts, but they need to be supported through the isolation of a potentially large number of additionally crafted features derived from the raw data. This feature preprocessing step can involve nontrivial digital signal processing (DSP) techniques. However, in many cases, the researchers interested in this type of activity recognition problems do not possess the necessary technical background for this feature-set development. The study aimed to present a novel application of established machine vision methods to provide interested researchers with an easier entry path into the HAR and ED fields. This can be achieved by removing the need for deep DSP skills through the use of transfer learning. This can be done by using a pretrained convolutional neural network (CNN) developed for machine vision purposes for exercise classification effort. The new method should simply require researchers to generate plots of the signals that they would like to build classifiers with, store them as images, and then place them in folders according to their training label before retraining the network. We applied a CNN, an established machine vision technique, to the task of ED. Tensorflow, a high-level framework for machine learning, was used to facilitate infrastructure needs. Simple time series plots generated directly from accelerometer and gyroscope signals are used to retrain an openly available neural network (Inception), originally developed for machine vision tasks. Data from 82 healthy volunteers, performing 5 different exercises while wearing a lumbar-worn inertial measurement unit (IMU), was collected. The ability of the

  15. Developments in Surrogating Methods

    Directory of Open Access Journals (Sweden)

    Hans van Dormolen

    2005-11-01

    Full Text Available In this paper, I would like to talk about the developments in surrogating methods for preservation. My main focus will be on the technical aspects of preservation surrogates. This means that I will tell you something about my job as Quality Manager Microfilming for the Netherlands’ national preservation program, Metamorfoze, which is coordinated by the National Library. I am responsible for the quality of the preservation microfilms, which are produced for Metamorfoze. Firstly, I will elaborate on developments in preservation methods in relation to the following subjects: · Preservation microfilms · Scanning of preservation microfilms · Preservation scanning · Computer Output Microfilm. In the closing paragraphs of this paper, I would like to tell you something about the methylene blue test. This is an important test for long-term storage of preservation microfilms. Also, I will give you a brief report on the Cellulose Acetate Microfilm Conference that was held in the British Library in London, May 2005.

  16. Development of quench detection/protection system based on active power method for superconducting magnet by using capacitor circuit

    International Nuclear Information System (INIS)

    Nanato, N.; Otsuka, T.; Hesaka, S.; Murase, S.

    2013-01-01

    Highlights: ► The authors have presented an active power method for quench detection. ► A method for improving its characteristics using a capacitor circuit was proposed. ► Quench detection/protection test for a Bi2223 superconducting coil was carried out. ► The proposed method was more useful than the conventional one. -- Abstract: When a quench occurs in a superconducting magnet, excessive joule heating in normal region may damage the magnet. It is necessary to detect the quench as soon as possible and discharge magnetic energy stored in the magnet. The authors have presented a quench detection/protection system based on an active power method which detects the quench regardless of a self-inductive and mutual-inductive voltages and electromagnetic noise. In the conventional active power method, the inductive voltages are removed by cancel coils. In this paper, the authors propose a method to cancel an inductive voltage using a capacitor circuit. The quench detection/protection system becomes more precise and smaller than the conventional system through the capacitor circuit

  17. Development of partitioning method

    International Nuclear Information System (INIS)

    Kubota, Kazuo; Dojiri, Shigeru; Kubota, Masumitsu

    1988-10-01

    The literature survey was carried out on the amount of natural resources, behaviors in reprocessing process and in separation and recovery methods of the platinum group elements and technetium which are contained in spent fuel. The essential results are described below. (1) The platinum group elements, which are contained in spent fuel, are quantitatively limited, compared with total demand for them in Japan. And estimated separation and recovery cost is rather high. In spite of that, development of these techniques is considered to be very important because the supply of these elements is almost from foreign resources in Japan. (2) For recovery of these elements, studies of recovery from undisolved residue and from high level liquid waste (HLLW) also seem to be required. (3) As separation and recovery methods, following techniques are considered to be effective; lead extraction, liquid metal extraction, solvent extraction, ion-exchange, adsorption, precipitation, distillation, electrolysis or their combination. (4) But each of these methods has both advantages and disadvantages. So development of such processes largely depends on future works. (author) 94 refs

  18. Development of partitioning method

    International Nuclear Information System (INIS)

    Kondo, Yasuo; Kubota, Masumitsu; Abe, Tadashi; Nagato, Kotaro.

    1991-09-01

    Spent fuels from nuclear power stations contain many useful elements, which can be utilized as heat and irradiation sources, radioisotope, elemental resource, etc. Their recovery from spent fuel and effective uses have the advantages in not only converting the radioactive waste to beneficial resources but also promoting rationalization of the management and disposal of the radioactive wastes. In present study, published literature related to recovery and utilization of useful elements in spent fuel was mainly surveyed, present states and trends in their research and development were analyzed, and their future prospects were conjectured. Research and development on recovery and utilization of useful elements are being continued mainly in USA, Europe and Japan. A transportable food irradiator with Cs-137 and an electric power source with Sr-90 for remote weather station are typical examples in major past applications. However, research and development on recovery and utilization are not so much active and the future efforts should be expected hereafter. Present study was conducted under the auspices of the Science and Technology Agency of Japan. (author)

  19. Development of a test method to access the sludge reduction potential of aquatic organisms in activated sludge

    NARCIS (Netherlands)

    Buijs, B.R.; Klapwijk, A.; Elissen, H.J.H.; Rulkens, W.H.

    2008-01-01

    This article shows the development of a quantitative sludge reduction test method, which uses the sludge consuming aquatic worm Lumbriculus variegatus (Oligochaeta, Lumbriculidae). Essential for the test are sufficient oxygen supply and the presence of a non-stirred layer of sludge for burrowing of

  20. Active Learning Methods

    Science.gov (United States)

    Zayapragassarazan, Z.; Kumar, Santosh

    2012-01-01

    Present generation students are primarily active learners with varied learning experiences and lecture courses may not suit all their learning needs. Effective learning involves providing students with a sense of progress and control over their own learning. This requires creating a situation where learners have a chance to try out or test their…

  1. Development of quantitative structure activity relationship (QSAR) model for disinfection byproduct (DBP) research: A review of methods and resources

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Baiyang, E-mail: poplar_chen@hotmail.com [Harbin Institute of Technology Shenzhen Graduate School, Shenzhen Key Laboratory of Water Resource Utilization and Environmental Pollution Control, Shenzhen 518055 (China); Zhang, Tian [Harbin Institute of Technology Shenzhen Graduate School, Shenzhen Key Laboratory of Water Resource Utilization and Environmental Pollution Control, Shenzhen 518055 (China); Bond, Tom [Department of Civil and Environmental Engineering, Imperial College, London SW7 2AZ (United Kingdom); Gan, Yiqun [Harbin Institute of Technology Shenzhen Graduate School, Shenzhen Key Laboratory of Water Resource Utilization and Environmental Pollution Control, Shenzhen 518055 (China)

    2015-12-15

    Quantitative structure–activity relationship (QSAR) models are tools for linking chemical activities with molecular structures and compositions. Due to the concern about the proliferating number of disinfection byproducts (DBPs) in water and the associated financial and technical burden, researchers have recently begun to develop QSAR models to investigate the toxicity, formation, property, and removal of DBPs. However, there are no standard procedures or best practices regarding how to develop QSAR models, which potentially limit their wide acceptance. In order to facilitate more frequent use of QSAR models in future DBP research, this article reviews the processes required for QSAR model development, summarizes recent trends in QSAR-DBP studies, and shares some important resources for QSAR development (e.g., free databases and QSAR programs). The paper follows the four steps of QSAR model development, i.e., data collection, descriptor filtration, algorithm selection, and model validation; and finishes by highlighting several research needs. Because QSAR models may have an important role in progressing our understanding of DBP issues, it is hoped that this paper will encourage their future use for this application.

  2. Development of quantitative structure activity relationship (QSAR) model for disinfection byproduct (DBP) research: A review of methods and resources

    International Nuclear Information System (INIS)

    Chen, Baiyang; Zhang, Tian; Bond, Tom; Gan, Yiqun

    2015-01-01

    Quantitative structure–activity relationship (QSAR) models are tools for linking chemical activities with molecular structures and compositions. Due to the concern about the proliferating number of disinfection byproducts (DBPs) in water and the associated financial and technical burden, researchers have recently begun to develop QSAR models to investigate the toxicity, formation, property, and removal of DBPs. However, there are no standard procedures or best practices regarding how to develop QSAR models, which potentially limit their wide acceptance. In order to facilitate more frequent use of QSAR models in future DBP research, this article reviews the processes required for QSAR model development, summarizes recent trends in QSAR-DBP studies, and shares some important resources for QSAR development (e.g., free databases and QSAR programs). The paper follows the four steps of QSAR model development, i.e., data collection, descriptor filtration, algorithm selection, and model validation; and finishes by highlighting several research needs. Because QSAR models may have an important role in progressing our understanding of DBP issues, it is hoped that this paper will encourage their future use for this application.

  3. Activation of Students with Various Teaching Methods

    DEFF Research Database (Denmark)

    Andersen, Shuang Ma

    2011-01-01

    A group of teaching methodes to active engineer students have been tried out. The methodes are developed based on the Pedagogical Cyclic Workflow (PCW). Comparing with earlier evaluation, positive feedback is achieved among the students.......A group of teaching methodes to active engineer students have been tried out. The methodes are developed based on the Pedagogical Cyclic Workflow (PCW). Comparing with earlier evaluation, positive feedback is achieved among the students....

  4. Bonding of Si wafers by surface activation method for the development of high efficiency high counting rate radiation detectors

    International Nuclear Information System (INIS)

    Kanno, Ikuo; Yamashita, Makoto; Onabe, Hideaki

    2006-01-01

    Si wafers with two different resistivities ranging over two orders of magnitude were bonded by the surface activation method. The resistivities of bonded Si wafers were measured as a function of annealing temperature. Using calculations based on a model, the interface resistivities of bonded Si wafers were estimated as a function of the measured resistivities of bonded Si wafers. With thermal treatment from 500degC to 900degC, all interfaces showed high resistivity, with behavior that was close to that of an insulator. Annealing at 1000degC decreased the interface resistivity and showed close to ideal bonding after thermal treatment at 1100degC. (author)

  5. Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity

    International Nuclear Information System (INIS)

    Dillon, Roslyn; Greig, Michael J.; Bhat, B. Ganesh

    2008-01-01

    Stearoyl-CoA desaturase 1 (SCD1) is an enzyme that catalyzes the rate-limiting step in de novo synthesis of monounsaturated fatty acids-mainly oleate and palmitoleate from stearoyl-CoA and palmitoyl-Co A, respectively. These products are the most abundant monounsaturated fatty acids in membrane phospholipids, triglycerides, cholesterol esters. Reports on mice with a targeted disruption of SCD1 gene (SCD1-/-) exhibit improved glucose tolerance and insulin sensitivity compared to wild-type suggesting SCD1 could be a therapeutic target for diabetes and related metabolic diseases. Measurement of SCD1 activity is technically challenging and traditional cell-based SCD1 assay procedure is labor intensive with low throughput. We describe here a novel medium-throughput LC/MS cell-based assay for determining cellular SCD1 activity, facilitating screening of potential SCD1 inhibitor compounds. Confluent HepG2 cells were grown in 24-well plates and incubated with vehicle or an inhibitor followed by incubation with deuterium labeled saturated fatty acid substrates. Total cell lipids were extracted and the conversion of stearate to oleate was measured by liquid chromatography-mass spectrometry. Sterculate, a known inhibitor of SCD1, inhibited the enzyme activity in a dose dependent manner in this assay with a calculated EC 50 of 247 nM. The medium-throughput method described here is an important step towards identifying an inhibitor of SCD1 to treat diabetes and related metabolic diseases

  6. Tiamulin activity against fastidious and nonfastidious veterinary and human bacterial isolates: initial development of in vitro susceptibility test methods.

    Science.gov (United States)

    Jones, Ronald N; Pfaller, Michael A; Rhomberg, Paul R; Walter, Donald H

    2002-02-01

    Tiamulin is a pleuromutilin derivative used in veterinary practice for the control and specific therapy of infections in swine. This report summarizes studies to establish standardized susceptibility testing methods, interpretive criteria, and reagent details for use in veterinary methods recently developed by the National Committee for Clinical Laboratory Standards (NCCLS) (standards M31-A and M37-A, NCCLS, Wayne, Pa., 1999). A total of 636 fastidious and nonfastidious animal and human pathogens were processed by using media and procedures described by the NCCLS. Tiamulin disk diffusion tests used a 30-microg disk concentration, and the proposed MIC breakpoints corresponding to levels achievable in animal target tissues (lung) were or =32 microg/ml for resistance. Correlate zone diameters for specific nonfastidious species were as follows: for Pasteurella multocida and staphylococci tested on Mueller-Hinton agar, susceptibility at > or =19 mm and resistance at or =16 mm and resistance at or =9 mm) was suggested for veterinary fastidious medium broth and enriched chocolate Mueller-Hinton agar. Absolute categorical agreement between NCCLS dilution and disk diffusion test results with these criteria ranged from 90.5 to 96.2%. Tiamulin susceptibility testing methods appear to be accurate in their categorical classification for indicated species, and their availability will allow immediate testing of animal isolates to guide therapy via appropriate levels of dosing and to monitor the development of resistance for agents in this unique class.

  7. Activity based costing (ABC Method

    Directory of Open Access Journals (Sweden)

    Prof. Ph.D. Saveta Tudorache

    2008-05-01

    Full Text Available In the present paper the need and advantages are presented of using the Activity BasedCosting method, need arising from the need of solving the information pertinence issue. This issue has occurreddue to the limitation of classic methods in this field, limitation also reflected by the disadvantages ofsuch classic methods in establishing complete costs.

  8. Development of partitioning method

    International Nuclear Information System (INIS)

    Kobayashi, Tsutomu; Shirahashi, Koichi; Kubota, Masumitsu

    1989-11-01

    Precipitation behavior of elements in a high-level liquid waste (HLW) was studied by using the simulated liquid waste, when the transuranic elements group was precipitated and separated as oxalate from HLW generated from the reprocessing of spent nuclear fuel. The results showed that over 90 % of strontium and barium were precipitated when oxalic acid was directly added to HLW to precipitate the transuranic elements group, and the percentages of these elements precipitated were affected by molybdenum and or zirconium. Therefore, a method of adding oxalic acid into the filtrate was studied after removing previously molybdenum and zirconium as precipitate by denitrating HLW, and it was found that precipitated fractions of strontium and barium could be suppressed about 10 %. Adding oxalic acid under the co-existance of ascorbic acid is effective for quantitative precipitation of neptunium in HLW. In this case, it was found that adding ascorbic acid had little influence on precipitation behavior of the other elements except palladium. (author)

  9. Development of evaluation method of collective dose of general public considering the daily life activity and time use

    International Nuclear Information System (INIS)

    Nagaoka, Toshi; Saito, Kimiaki; Sakamoto, Ryuichi; Tsutsumi, Masahiro; Moriuchi, Shigeru

    1994-11-01

    A code for evaluation of collective dose of general public to natural radiation has been developed, in which the variation of dose rate due to place of stay is taken into consideration. Only external exposure to natural radiation is subject to discussion in this report. Strict manner of dose evaluation requires the dose rate and the time period of stay for each place and for each person. It is possible to know (measure) them all, but not practicable. In this code, dose rate information was obtained from actually measured data by the authors and estimation based on the environmental conditions. Information on the time period of stay was obtained from a Survey Data on Time Use and Leisure Activities by Management and Coordination Agency, and from Statistical Yearbook of Tokyo with some realistic assumptions. By using them, collective dose was evaluated taking both the daily life style and dose rate varying place by place into consideration. In this report, the dose evaluation code and the results about doses for Tokyo citizens are mentioned. (author)

  10. Development of decontamination methods

    International Nuclear Information System (INIS)

    Kunze, S.; Dippel, T.; Hentschel, D.

    1976-01-01

    PVC floorings, fabricated by mixing of the basic components, showed no relation between content of fillers and decontamination results. Decontamination results are partly poorer, if the flooring contains a high concentration of the filler, especially if the latter consists mainly of hydrophilic materials. The coloring of the floorings seems to have no influence on the decontamination. Rubber floorings, fabricated by chemical reactions between polymers, vulcanization materials and fillers, show decontamination results depending definitely from the proper choice of the filler. Flooring types, containing lampblack, graphite, kaoline, barium sulfate and titanium oxide are easy to decontaminate. Increasing contents of hydrophilic filler cause a fall off in the decontamination results. The decontamination effectiveness and the homogenity of cleaning pastes based on hydrochloric acid, nitric acid, titanium oxide and polyethylene powders is strongly depended on the content of hydrochloric acid. Reduction of the content of this component to less than 2 w/O remains the effectiveness unchanged only if the titanium oxide-polyethylene powder mixture is substituted by a high density, highly surface active powder material. This type of paste containing no hydrochloric acid shows nearly the same decontamination effectiveness as standard pickling pastes containing about 30% hydrochlorid acid. Properly prepared salt powder turn out to be easily and successfully applied to metal surfaces by a flame spray technique. The thin layer of molten salts is a very effective decontamination to samples contaminated in the primary loop of a PWR. (orig.) [de

  11. Development and optimization of methods for the radiofluorination of aromatic compounds with specific, high fluorine-18 activity

    International Nuclear Information System (INIS)

    Franken, K.

    1987-06-01

    The positron emitter fluorine-18 (T 1/2 = 110 min) is an ideal radionuclide for analogue tracers in positron emission tomography (PET). In this study the production of the electrophilic species [ 18 F]-F 2 , [ 18 F]-CH 3 CO 2 F and to some extent [ 18 F]-XeF 2 has been optimized with respect to yield and specific activity. Selectivity and reactivity of these species have been studied in simple aromatic model compounds. Fluorine was produced via the 20 Ne(d,α) 18 F reaction. The effect of target material, dimensions, amount of carrier (F 2 ), pressure, beam current and irradiation time was studied. Reactivity of [ 18 F]-F 2 and [ 18 F]-CH 3 CO 2 F with respect to hydrogen subsitution was systematically studied in a series of benzene derivatives (C 6 H 5 X, X = CF 3 , I, Br, CL, F, H, CH 3 , OCH 3 , OH) in various solvents (CHCl 3 , CFCl 3 , CH 3 CN, CH 3 OH, CF 3 COOH). The radiochemical yield of 18 F-for-H-substitution in the aromatic ring increased with increasing acceptor number (AN) of the solvent. The electrophilic nature of both fluorination agents was confirmed by a Hammett plot. As expected, [ 18 F]-CH 3 CO 2 F showed a higher selectivity than [ 18 F]-F 2 . Direct radiofluorination with [ 18 F]-F 2 and [ 18 F]-CH 3 CO 2 F was successfully applied to the biomolecules phenylalanine, tyrosine and DOPA. As potential methods for no-carrier-added (n.c.a.) radiofluorination some less common dediazoniation reactions were also studied. (orig./RB) [de

  12. Development of standard methods for activity measurement of natural radionuclides in waterworks as basis for dose and risk assessment—First results of an Austrian study

    International Nuclear Information System (INIS)

    Stietka, M.; Baumgartner, A.; Seidel, C.; Maringer, F.J.

    2013-01-01

    A comprehensive study with the aim to evaluate the risks due to radiation exposure for workers in water supply is conducted in 21 Austrian waterworks. The development of standard methods for the assessment of occupational exposure of water work staff is a part of this study. Preliminary results of this study show a wide range of Rn-222 activity concentration in waterworks with values from (28±10) Bq/m 3 to (38,000±4000) Bq/m 3 . Also seasonal variations of the Rn-222 activity concentration could be observed. - Highlights: • In this study operational exposure of water work staff was evaluated. • The Rn-222 concentration in indoor air in waterworks was measured for 1 year. • Results show a wide range of Rn-222 activity concentration in waterworks. • Seasonal variations of the Rn-222 activity concentration could be observed

  13. Development and Application of a New Microarray- Based Method for High-Throughput Screening of Carbohydrate Active Enzymes

    DEFF Research Database (Denmark)

    Vidal Melgosa, Silvia

    single defined polysaccharides, mixtures of defined polysaccharides and complex biomass extracts. Furthermore, the capacity of the technique to analyse endo- and exo-acting glycoside hydrolases, polysaccharide lyases, carbohydrate esterases and lytic polysaccharide monooxygenases has been confirmed...... will contribute to both the discovery of CAZymes and the empirical characterisation of their activities, thus aiding their industrial utilisation and biological understanding...

  14. Method Development in Forensic Toxicology.

    Science.gov (United States)

    Peters, Frank T; Wissenbach, Dirk K; Busardo, Francesco Paolo; Marchei, Emilia; Pichini, Simona

    2017-01-01

    In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. The presented article will provide an overview on the process of developing methods for forensic applications. This includes the definition of the method's purpose (e.g. qualitative vs quantitative) and the analytes to be included, choosing an appropriate sample matrix, setting up separation and detection systems as well as establishing a versatile sample preparation. Method development is concluded by an optimization process after which the new method is subject to method validation. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  15. Development of a physical activity monitoring tool for Thai medical schools: a protocol for a mixed methods study

    OpenAIRE

    Wattanapisit, Apichai; Vijitpongjinda, Surasak; Saengow, Udomsak; Amaek, Waluka; Thanamee, Sanhapan; Petchuay, Prachyapan

    2017-01-01

    Introduction Physical activity (PA) is important in promoting health, as well as in the treatment and prevention of diseases. However, insufficient PA is still a global health problem and it is also a problem in medical schools. PA training in medical curricula is still sparse or non-existent. There is a need for a comprehensive understanding of the extent of PA in medical schools through several indicators, including people, places and policies. This study includes a survey of the PA prevale...

  16. Activity – based costing method

    Directory of Open Access Journals (Sweden)

    Èuchranová Katarína

    2001-06-01

    Full Text Available Activity based costing is a method of identifying and tracking the operating costs directly associated with processing items. It is the practice of focusing on some unit of output, such as a purchase order or an assembled automobile and attempting to determine its total as precisely as poccible based on the fixed and variable costs of the inputs.You use ABC to identify, quantify and analyze the various cost drivers (such as labor, materials, administrative overhead, rework. and to determine which ones are candidates for reduction.A processes any activity that accepts inputs, adds value to these inputs for customers and produces outputs for these customers. The customer may be either internal or external to the organization. Every activity within an organization comprimes one or more processes. Inputs, controls and resources are all supplied to the process.A process owner is the person responsible for performing and or controlling the activity.The direction of cost through their contact to partial activity and processes is a new modern theme today. Beginning of this method is connected with very important changes in the firm processes.ABC method is a instrument , that bring a competitive advantages for the firm.

  17. Development of a method for determining the location of heterogeneous activity present in 200 litre waste drum using USB based MCS system

    International Nuclear Information System (INIS)

    Singh, Sarbjit; Mhatre, Amol; Sagar, Veena; Gupta, Nidhi

    2014-01-01

    A method was developed for determining the location of activity present in 200 litre waste drum using USB based MCS system coupled to a segmented gamma ray scanner. 137 Cs source was kept at various distances from centre of the drum along the axis of the detector. Drum was rotated and the activity profiles were determined as a function of angle of rotation. The plot of the count rate as a function of angle of rotation was found to have two peaks. The experimental and calculated data were found to match well at all angles. Present studies have shown that the ratio of height and width of the profile at angles of 0 ° and 180° can be used to determine the location of the activity in the drum. (author)

  18. Development of the Method of Bacterial Leaching of Metals out of Low-Grade Ores, Rocks, and Industrial Wastes Using Neutron Activation Analysis

    CERN Document Server

    Tsertsvadze, L A; Petriashvili, Sh G; Chutkerashvili, D G; Kirkesali, E I; Frontasyeva, M V; Pavlov, S S; Gundorina, S F

    2001-01-01

    The results of preliminary investigations aimed at the development of an economical and easy to apply technique of bacterial leaching of rare and valuable metals out of low-grade ores, complex composition ores, rocks, and industrial wastes in Georgia are discussed. The main groups of microbiological community of the peat suspension used in the experiments of bacterial leaching are investigated and the activity of particular microorganisms in the leaching of probes with different mineral compositions is assessed. The element composition of the primary and processed samples was investigated by the epithermal neutron activation analysis method and the enrichment/subtraction level is estimated for various elements. The efficiency of the developed technique to purify wastes, extract some scrace metals, and enrich ores or rocks in some elements, e.g. Au, U, Th, Cs, Sr, Rb, Sc, Zr, Hf, Ta, Gd, Er, Lu, Ce, etc., is demonstrated.

  19. Development of a NIR-based blend uniformity method for a drug product containing multiple structurally similar actives by using the quality by design principles.

    Science.gov (United States)

    Lin, Yiqing; Li, Weiyong; Xu, Jin; Boulas, Pierre

    2015-07-05

    The aim of this study is to develop an at-line near infrared (NIR) method for the rapid and simultaneous determination of four structurally similar active pharmaceutical ingredients (APIs) in powder blends intended for the manufacturing of tablets. Two of the four APIs in the formula are present in relatively small amounts, one at 0.95% and the other at 0.57%. Such small amounts in addition to the similarity in structures add significant complexity to the blend uniformity analysis. The NIR method is developed using spectra from six laboratory-created calibration samples augmented by a small set of spectra from a large-scale blending sample. Applying the quality by design (QbD) principles, the calibration design included concentration variations of the four APIs and a main excipient, microcrystalline cellulose. A bench-top FT-NIR instrument was used to acquire the spectra. The obtained NIR spectra were analyzed by applying principal component analysis (PCA) before calibration model development. Score patterns from the PCA were analyzed to reveal relationship between latent variables and concentration variations of the APIs. In calibration model development, both PLS-1 and PLS-2 models were created and evaluated for their effectiveness in predicting API concentrations in the blending samples. The final NIR method shows satisfactory specificity and accuracy. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Study and development of a method allowing the identification of actinides inside nuclear waste packages, by active neutron or photon interrogation and delayed gamma-ray spectrometry

    International Nuclear Information System (INIS)

    Carrel, F.

    2007-10-01

    An accurate estimation of the alpha-activity of a nuclear waste package is necessary to select the best mode of storage. The main purpose of this work is to develop a non-destructive active method, based on the fission process and allowing the identification of actinides ( 235 U, 238 U, 239 Pu). These three elements are the main alpha emitters contained inside a package. Our technique is based on the detection of delayed gammas emitted by fission products. These latter are created by irradiation with the help of a neutron or photon beam. Performances of this method have been investigated after an Active Photon or Neutron Interrogation (INA or IPA). Three main objectives were fixed in the framework of this thesis. First, we measured many yields of photofission products to compensate the lack of data in the literature. Then, we studied experimental performances of this method to identify a given actinide ( 239 Pu in fission, 235 U in photofission) present in an irradiated mixture. Finally, we assessed the application of this technique on different mock-up packages for both types of interrogation (118 l mock-up package containing EVA in fission, 220 l mock-up package with a wall of concrete in photofission). (author)

  1. Applied research and development of neutron activation analysis - Development of the precise analysis method for plastic materials by the use of NAA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kil Yong; Sim, Sang Kwan; Yoon, Yoon Yeol; Chun, Sang Ki [Korea Institute of Geology, Mining and Materials, Taejon (Korea)

    2000-04-01

    The demand for inorganic analysis of plastics has significantly increased in the fields of microelectronic, environmental, nuclear and resource recycling. The difficulties of chemical analysis methods have led to the application of NAA which has great advantages of non-destructivity, freedom from blank, high sensitivity. The goal of the present work is to optimize and to develop the NAA procedures for the inorganic analysis of plastics. Even though NAA has unique advantages, it has two problems for plastics. One is the contamination by metallic utensils during sample treatment and the other is destruction of sample ampule due to pressure build-up by hydrogen and methane gas formed from oxyhydrogenation reaction with neutrons. For the first problem, large plastics were cut to pieces after immersion in liquid nitrogen. And the second problem has been solved by making an aperture on top side of sample ampule. These research results have been applied to analysis of various plastic materials which were used in food, drug containers and toys for children. Moreover, korean irradiation rabbit could be produced by the application of the results and standard reference materials of plastics which were used for the analysis in XRF and ICP could be produced. 36 refs., 6 figs., 37 tabs (Author)

  2. Biological Methods and Manual Development

    Science.gov (United States)

    EPA scientists conduct research to develop and evaluate analytical methods for the identification, enumeration, evaluation of aquatic organisms exposed to environmental stressors and to correlate exposures with effects on chemical and biological indicators

  3. DDOT MXD+ method development report.

    Science.gov (United States)

    2015-09-01

    Mixed-use development has become increasingly common across the country, including Washington, D.C. : However, a straightforward and empirically validated method for evaluating the traffic impacts of such : projects is still needed. The data presente...

  4. Negotiating a Systems Development Method

    Science.gov (United States)

    Karlsson, Fredrik; Hedström, Karin

    Systems development methods (or methods) are often applied in tailored version to fit the actual situation. Method tailoring is in most the existing literature viewed as either (a) a highly rational process with the method engineer as the driver where the project members are passive information providers or (b) an unstructured process where the systems developer makes individual choices, a selection process without any driver. The purpose of this chapter is to illustrate that important design decisions during method tailoring are made by project members through negotiation. The study has been carried out using the perspective of actor-network theory. Our narratives depict method tailoring as more complex than (a) and (b) show the driver role rotates between the project members, and design decisions are based on influences from several project members. However, these design decisions are not consensus decisions.

  5. Studies on application of neutron activation analysis -Applied research on air pollution monitoring and development of analytical method of environmental samples

    International Nuclear Information System (INIS)

    Chung, Yong Sam; Moon, Jong Hwa; Chung, Young Ju; Jeong, Eui Sik; Lee, Sang Mi; Kang, Sang Hun; Cho, Seung Yeon; Kwon, Young Sik; Chung, Sang Wuk; Lee, Kyu Sung; Chun, Ki Hong; Kim, Nak Bae; Lee, Kil Yong; Yoon, Yoon Yeol; Chun, Sang Ki.

    1997-09-01

    This research report is written for results of applied research on air pollution monitoring using instrumental neutron activation analysis. For identification and standardization of analytical method, 24 environmental samples are analyzed quantitatively, and accuracy and precision of this method are measured. Using airborne particulate matter and biomonitor chosen as environmental indicators, trace elemental concentrations of sample collected at urban and rural site monthly are determined ant then the calculation of statistics and the factor analysis are carried out for investigation of emission source. Facilities for NAA are installed in a new HANARO reactor, functional test is performed for routine operation. In addition, unified software code for NAA is developed to improve accuracy, precision and abilities of analytical processes. (author). 103 refs., 61 tabs., 19 figs

  6. Development of an enzyme-linked immunosorbent assay-based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate.

    Science.gov (United States)

    Oubihi, M; Kitajima, K; Kobayashi, K; Adachi, T; Aoki, N; Matsuda, T

    1998-03-15

    A lectin-assisted enzyme-linked immunosorbent assay (ELISA)-based method using a synthetic glycopolymer as an acceptor substrate was developed for measuring beta 1,4-galactosyltransferase (GalT) activity. A polyacrylamide derivative having a beta-linked N-acetylglucosamine (GlcNAc beta) moiety on each monomeric unit was synthesized chemically and immobilized on a polystyrene microtiter plate as an acceptor substrate for GalT. After the plate was incubated with bovine GalT, the enzyme reaction product, beta-linked Gal residue on the polyacrylamide-bound GlcNAc residue, was detected by using Ricinus communis agglutinin 1 (RCA1), rabbit anti-RCA1 antibody, and a peroxidase-labeled anti-rabbit IgG. The lowest GalT concentration detectable by this method was about 0.5 mU/ml, which is comparable to those by the previously reported ELISA-based assays. The unique property of the glycopolymer, PAP(GlcNAc beta), of binding noncovalently but tightly to the polystyrene microtiter plate allowed the use of this acceptor substrate for the GalT activity measurement even in the presence of 1% Triton CF-54 and X-100. Our system was successfully applied to assess GalT activity in milk of various mammals.

  7. Active learning methods for interactive image retrieval.

    Science.gov (United States)

    Gosselin, Philippe Henri; Cord, Matthieu

    2008-07-01

    Active learning methods have been considered with increased interest in the statistical learning community. Initially developed within a classification framework, a lot of extensions are now being proposed to handle multimedia applications. This paper provides algorithms within a statistical framework to extend active learning for online content-based image retrieval (CBIR). The classification framework is presented with experiments to compare several powerful classification techniques in this information retrieval context. Focusing on interactive methods, active learning strategy is then described. The limitations of this approach for CBIR are emphasized before presenting our new active selection process RETIN. First, as any active method is sensitive to the boundary estimation between classes, the RETIN strategy carries out a boundary correction to make the retrieval process more robust. Second, the criterion of generalization error to optimize the active learning selection is modified to better represent the CBIR objective of database ranking. Third, a batch processing of images is proposed. Our strategy leads to a fast and efficient active learning scheme to retrieve sets of online images (query concept). Experiments on large databases show that the RETIN method performs well in comparison to several other active strategies.

  8. Optimization methods for activities selection problems

    Science.gov (United States)

    Mahad, Nor Faradilah; Alias, Suriana; Yaakop, Siti Zulaika; Arshad, Norul Amanina Mohd; Mazni, Elis Sofia

    2017-08-01

    Co-curriculum activities must be joined by every student in Malaysia and these activities bring a lot of benefits to the students. By joining these activities, the students can learn about the time management and they can developing many useful skills. This project focuses on the selection of co-curriculum activities in secondary school using the optimization methods which are the Analytic Hierarchy Process (AHP) and Zero-One Goal Programming (ZOGP). A secondary school in Negeri Sembilan, Malaysia was chosen as a case study. A set of questionnaires were distributed randomly to calculate the weighted for each activity based on the 3 chosen criteria which are soft skills, interesting activities and performances. The weighted was calculated by using AHP and the results showed that the most important criteria is soft skills. Then, the ZOGP model will be analyzed by using LINGO Software version 15.0. There are two priorities to be considered. The first priority which is to minimize the budget for the activities is achieved since the total budget can be reduced by RM233.00. Therefore, the total budget to implement the selected activities is RM11,195.00. The second priority which is to select the co-curriculum activities is also achieved. The results showed that 9 out of 15 activities were selected. Thus, it can concluded that AHP and ZOGP approach can be used as the optimization methods for activities selection problem.

  9. eHealth program to empower patients in returning to normal activities and work after gynecological surgery: intervention mapping as a useful method for development.

    Science.gov (United States)

    Vonk Noordegraaf, Antonie; Huirne, Judith A F; Pittens, Carina A; van Mechelen, Willem; Broerse, Jacqueline E W; Brölmann, Hans A M; Anema, Johannes R

    2012-10-19

    Full recovery after gynecological surgery takes much longer than expected regardless of surgical technique or the level of invasiveness. After discharge, detailed convalescence recommendations are not provided to patients typically, and postoperative care is fragmented, poorly coordinated, and given only on demand. For patients, this contributes to irrational beliefs and avoidance of resumption of activities and can result in a prolonged sick leave. To develop an eHealth intervention that empowers gynecological patients during the perioperative period to obtain timely return to work (RTW) and prevent work disability. The intervention mapping (IM) protocol was used to develop the eHealth intervention. A literature search about behavioral and environmental conditions of prolonged sick leave and delayed RTW in patients was performed. Patients' needs, attitudes, and beliefs regarding postoperative recovery and resumption of work were identified through focus group discussions. Additionally, a literature search was performed to obtain determinants, methods, and strategies for the development of a suitable interactive eHealth intervention to empower patients to return to normal activities after gynecological surgery, including work. Finally, the eHealth intervention was evaluated by focus group participants, medical doctors, and eHealth specialists through questionnaires. Twenty-one patients participated in the focus group discussions. Sufficient, uniform, and tailored information regarding surgical procedures, complications, and resumption of activities and work were considered most essential. Knowing who to contact in case of mental or physical complaints, and counseling and tools for work reintegration were also considered important. Finally, opportunities to exchange experiences with other patients were a major issue. Considering the determinants of the Attitude-Social influence-self-Efficacy (ASE) model, various strategies based on a combination of theory and

  10. Overview of activities related to the WGCS/AG2 in the study of structural analysis methods and damage models for the development of design rules

    International Nuclear Information System (INIS)

    Buckthorpe, M.; White, P.; Guinovart, J.

    1994-01-01

    , two other areas, one related to Research and Development programmes the other to and industrial projects conducted by EU organizations, have been an important source of input to the WGCS work. Therefore, it could be mentioned that the work produced by the WGCS moves amongst the three boundary areas described above. Paper describes the outstanding studies and ongoing activities of the WGCS including simplified calculation methods and established computational techniques as well as constitutive equations needed for complicated material descriptions and benchmarks

  11. An active structure preservation method for developing functional graphitic carbon dots as an effective antibacterial agent and a sensitive pH and Al(iii) nanosensor.

    Science.gov (United States)

    Hou, Peng; Yang, Tong; Liu, Hui; Li, Yuan Fang; Huang, Cheng Zhi

    2017-11-16

    Functional engineering is a crucial prerequisite for specific and wide applications of optical probes. In this study, we proposed a facile active structure preservation (ASP) method to directly develop new self-functional graphitic carbon dots (g-CDs) through a hydrothermal synthesis route by taking ciprofloxacin hydrochloride, an antibiotic belonging to a group of fluoroquinolone drugs, as an example. To retain the functional structures of the starting materials, the reaction temperature is intentionally controlled below the decomposition temperature of the reactants that hold the functional groups. As a proof of concept, we successfully prepared g-CDs with ciprofloxacin-like structures on its surface, as identified by mass spectrometric (MS) analysis. The as-prepared g-CDs not only exhibit effective antibacterial activity towards the bacteria Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), but can also optically sense pH in the range from 5.02 to 9.91. Furthermore, the g-CDs can coordinate with aluminum ions to show a chelation-enhanced photoluminescence (CHEP) effect. These results indicate that the ASP method can be promising for engineering CDs with various properties.

  12. An analysis of the influence of production conditions on the development of the microporous structure of the activated carbon fibres using the LBET method

    Science.gov (United States)

    Kwiatkowski, Mirosław

    2017-12-01

    The paper presents the results of the research on the application of the new analytical models of multilayer adsorption on heterogeneous surfaces with the unique fast multivariant identification procedure, together called LBET method, as a tool for analysing the microporous structure of the activated carbon fibres obtained from polyacrylonitrile by chemical activation using potassium and sodium hydroxides. The novel LBET method was employed particularly to evaluate the impact of the used activator and the hydroxide to polyacrylonitrile ratio on the obtained microporous structure of the activated carbon fibres.

  13. Activating teaching methods in french language teaching

    OpenAIRE

    Kulhánková, Anna

    2009-01-01

    The subject of this diploma thesis is activating teaching methods in french language teaching. This thesis outlines the issues acitvating teaching methods in the concept of other teaching methods. There is a definition of teaching method, classification of teaching methods and characteristics of each activating method. In the practical part of this work are given concrete forms of activating teaching methods appropriate for teaching of french language.

  14. Work activities within sustainable development

    Directory of Open Access Journals (Sweden)

    Francisco Duarte

    2015-06-01

    Full Text Available This paper presents the main results of a Franco-Brazilian Research project entitled "Work, Innovation and Development". The aim is to conceptually consider work activity within sustainable development, and to contribute methodologically towards developing strategies for designing sustainable work systems. After a brief description of the factors and the dimensions that have contributed to the creation of ideas on sustainable development, we will put forward two main approaches for understanding work activity within the context of sustainability, these being: the durability of work activity and the development of work activities for sustainable development. Both approaches are presented and examples are given. This is followed by a discussion of the design of sustainable work systems that focuses particularly on the political and technical dimensions of project management.

  15. Developing a service user informed intervention to improve participation and ability to perform daily activities in primary Sjögren's syndrome: a mixed-methods study protocol.

    Science.gov (United States)

    Hackett, Katie L; Newton, Julia L; Deane, Katherine H O; Rapley, Tim; Deary, Vincent; Kolehmainen, Niina; Lendrem, Dennis; Ng, Wan-Fai

    2014-08-21

    A significant proportion of patients with primary Sjögren's syndrome (PSS) is functionally impaired and experience difficulties participating in various aspects of everyday life. There is currently no evidence of efficacy for non-pharmacological interventions aimed specifically at supporting the patients with PSS to improve their participation and ability to perform daily activities. This paper describes a research protocol for a mixed-methods study to develop an intervention to improve these outcomes. The protocol follows the Medical Research Council framework for complex interventions. We will use group concept mapping with the patients, adults who live with them and healthcare professionals to identify factors which prevent people with PSS from participating in daily life and performing daily activities. The factors will be prioritised by participants for importance and feasibility and will inform an intervention to be delivered within a National Health Service (NHS) setting. Evidence-based intervention techniques will be identified for the prioritised factors and combined into a deliverable intervention package. Key stakeholders will comment on the intervention content and mode of delivery through focus groups, and the data will be used to refine the intervention. The acceptability and feasibility of the refined intervention will be evaluated in a future study. The study has been approved by an NHS Research Ethics Committee, REC Reference: 13/NI/0190. The findings of this study will be disseminated in peer-reviewed journals and through presentation at national and international conferences. UKCRN Study ID: 15939. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Development of a fluorescence-activated cell sorting method coupled with whole genome amplification to analyze minority and trace Dehalococcoides genomes in microbial communities.

    Science.gov (United States)

    Lee, Patrick K H; Men, Yujie; Wang, Shanquan; He, Jianzhong; Alvarez-Cohen, Lisa

    2015-02-03

    Dehalococcoides mccartyi are functionally important bacteria that catalyze the reductive dechlorination of chlorinated ethenes. However, these anaerobic bacteria are fastidious to isolate, making downstream genomic characterization challenging. In order to facilitate genomic analysis, a fluorescence-activated cell sorting (FACS) method was developed in this study to separate D. mccartyi cells from a microbial community, and the DNA of the isolated cells was processed by whole genome amplification (WGA) and hybridized onto a D. mccartyi microarray for comparative genomics against four sequenced strains. First, FACS was successfully applied to a D. mccartyi isolate as positive control, and then microarray results verified that WGA from 10(6) cells or ∼1 ng of genomic DNA yielded high-quality coverage detecting nearly all genes across the genome. As expected, some inter- and intrasample variability in WGA was observed, but these biases were minimized by performing multiple parallel amplifications. Subsequent application of the FACS and WGA protocols to two enrichment cultures containing ∼10% and ∼1% D. mccartyi cells successfully enabled genomic analysis. As proof of concept, this study demonstrates that coupling FACS with WGA and microarrays is a promising tool to expedite genomic characterization of target strains in environmental communities where the relative concentrations are low.

  17. Development, validation and clinical application of a LC-MS/MS method for the simultaneous quantification of hydroxychloroquine and its active metabolites in human whole blood.

    Science.gov (United States)

    Soichot, Marion; Mégarbane, Bruno; Houzé, Pascal; Chevillard, Lucie; Fonsart, Julien; Baud, Frédéric J; Laprévote, Olivier; Bourgogne, Emmanuel

    2014-11-01

    A rapid, sensitive and specific method using liquid chromatography coupled to tandem mass spectrometry was developed for the simultaneous quantification of hydroxychloroquine (HCQ) and its three major metabolites in human whole blood. The assay, using a sample volume of 100μL, was linear in a dynamic 25-2000ng/mL range (R(2)>0.99) for all four compounds and suitable for the determination of elevated HCQ concentrations up to 20,000ng/mL, after appropriate sample dilution. Inter- and intra-assay precisions were <18.2% and accuracies were between 84% and 113% for any analyte. No matrix effects were observed. The assay was successfully applied to a blood sample obtained from one poisoned patient following a massive HCQ self-ingestion resulting in an estimated concentration of 19,500ng/mL on hospital admission. In this patient, HCQ metabolites were identified and quantified at 1123, 465 and 91ng/mL for monodesethylhydroxychloroquine, desethylchloroquine and bisdesethylchloroquine, respectively. Further investigations are still required to assess the usefulness of the simultaneous measurement of blood concentrations of HCQ and its three active metabolites for monitoring HCQ treatment and managing HCQ poisoning. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Chemometrically assisted development and validation of LC-MS/MS method for the analysis of potential genotoxic impurities in meropenem active pharmaceutical ingredient.

    Science.gov (United States)

    Grigori, Katerina; Loukas, Yannis L; Malenović, Anđelija; Samara, Vicky; Kalaskani, Anastasia; Dimovasili, Efi; Kalovidouri, Magda; Dotsikas, Yannis

    2017-10-25

    A sensitive Liquid Chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative analysis of three potential genotoxic impurities (318BP, M9, S5) in meropenem Active Pharmaceutical Ingredient (API). Due to the requirement for LOD values in ppb range, a high concentration of meropenem API (30mg/mL) had to be injected. Therefore, efficient determination of meropenem from its impurities became a critical aim of this study, in order to divert meropenem to waste, via a switching valve. ‎ After the selection of the important factors affecting analytes' elution, a Box-Behnken design was utilized to set the plan of experiments conducted with UV detector. As responses, the separation factor s between the last eluting impurity and meropenem, as well as meropenem retention factor k were used. Grid point search methodology was implemented aiming to obtain the optimal conditions that simultaneously comply to the conflicted criteria. Optimal mobile phase consisted of ACN, methanol and 0.09% HCOOH at a ratio 71/3.5/15.5v/v. All impurities and internal standard omeprazole were eluted before 7.5min and at 8.0min the eluents were directed to waste. The protocol was transferred to LC-MS/MS and validated according to ICH guidelines. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Fish sampling with active methods

    Czech Academy of Sciences Publication Activity Database

    Kubečka, Jan; Godo, O. R.; Hickley, P.; Prchalová, Marie; Říha, Milan; Rudstam, L.; Welcomme, R.

    2012-01-01

    Roč. 123, July (2012), s. 1-3 ISSN 0165-7836 Institutional support: RVO:60077344 Keywords : fish stock assessment * active and passive gear * intercalibration Subject RIV: EH - Ecology, Behaviour Impact factor: 1.695, year: 2012

  20. Evaluating the migration of ingredients from active packaging and development of dedicated methods: A study of two iron-based oxygen absorbers

    NARCIS (Netherlands)

    López-Cervantes, L.; Sánchez-Machado, D.I.; Pastorelli, S.; Rijk, R.; Paseiro-Losada, P.

    2003-01-01

    The behaviour of two commercial oxygen-scavenging products with respect to migration of active ingredients into foodstuffs was investigated. Migrants were identified, and by using appropriate analytical methods, migration was determined in a variety of liquid, solid or gelled food simulants and

  1. Analysis of Maths Learning Activities Developed By Pre-service Teachers in Terms of the Components of Content, Purpose, Application Methods

    Directory of Open Access Journals (Sweden)

    Çağla Toprak

    2014-04-01

    Full Text Available Today- when the influence of the alteration movement done in order to keep up with the age of the educational system is still continuing- the importance of teachers in students’ learning and achieving what is expected from the education system has been stated by the studies conducted (Hazır & Bıkmaz, 2006. Teachers own a critical role in the stage of both preparing teaching materials and using them (Stein & Smith, 1998b; Swan, 2007. When the existing curriculums –in particular, maths and geometry cirriculums- are analyzed, it can be observed that activities are the most significant teaching materials (Bozkurt, 2012. In fact, it is possible to characterize the existing curriculums as activity-based ones (Report of Workshop Examining Content of Primary School Curriculums According to Branches, 2010; Epö, 2005. Therefore, what sort of learning activities there are, what qualities they need to have, how to design and apply them are topics that must be elaborated (Uğurel et al., 2010.  At this point, our study to increase the skills of pre-service teachers during the process of developing activities was conducted with 27 pre-service teachers -19 girls 8 boys- studying in the 4th year in Mathematics Education Department at a state university in the Aegean Region. The activity designs the pre-service teachers developed considering the patterns given after a series of practice were analyzed in documents in terms of the aim of design and the form of practice. As a result of the studies, it is observed that pre-service teachers deal with the topics from the maths curriculum and these topics are of different grade levels. The result of the examination named as target component suggests that activities developed aim firstly at providing learning and this is followed by reinforcing the concepts already learned. It is stated that pre-service teachers prefer mostly small group (cooperative studies in the activities they develop.Key Words:

  2. Development of methods for body composition studies

    International Nuclear Information System (INIS)

    Mattsson, Soeren; Thomas, Brian J

    2006-01-01

    This review is focused on experimental methods for determination of the composition of the human body, its organs and tissues. It summarizes the development and current status of fat determinations from body density, total body water determinations through the dilution technique, whole and partial body potassium measurements for body cell mass estimates, in vivo neutron activation analysis for body protein measurements, dual-energy absorptiometry (DEXA), computed tomography (CT) and magnetic resonance imaging (MRI, fMRI) and spectroscopy (MRS) for body composition studies on tissue and organ levels, as well as single- and multiple-frequency bioimpedance (BIA) and anthropometry as simple easily available methods. Methods for trace element analysis in vivo are also described. Using this wide range of measurement methods, together with gradually improved body composition models, it is now possible to quantify a number of body components and follow their changes in health and disease. (review)

  3. Development of methods for body composition studies

    Energy Technology Data Exchange (ETDEWEB)

    Mattsson, Soeren [Department of Radiation Physics, Lund University, Malmoe University Hospital, SE-205 02 Malmoe (Sweden); Thomas, Brian J [School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, QLD 4001 (Australia)

    2006-07-07

    This review is focused on experimental methods for determination of the composition of the human body, its organs and tissues. It summarizes the development and current status of fat determinations from body density, total body water determinations through the dilution technique, whole and partial body potassium measurements for body cell mass estimates, in vivo neutron activation analysis for body protein measurements, dual-energy absorptiometry (DEXA), computed tomography (CT) and magnetic resonance imaging (MRI, fMRI) and spectroscopy (MRS) for body composition studies on tissue and organ levels, as well as single- and multiple-frequency bioimpedance (BIA) and anthropometry as simple easily available methods. Methods for trace element analysis in vivo are also described. Using this wide range of measurement methods, together with gradually improved body composition models, it is now possible to quantify a number of body components and follow their changes in health and disease. (review)

  4. Development of a Scintillation Proximity Assay (SPA) Based, High Throughput Screening Feasible Method for the Identification of PDE12 Activity Modulators.

    Science.gov (United States)

    Mang, Samuel; Bucher, Hannes; Nickolaus, Peter

    2016-01-01

    The scintillation proximity assay (SPA) technology has been widely used to establish high throughput screens (HTS) for a range of targets in the pharmaceutical industry. PDE12 (aka. 2'- phosphodiesterase) has been published to participate in the degradation of oligoadenylates that are involved in the establishment of an antiviral state via the activation of ribonuclease L (RNAse-L). Degradation of oligoadenylates by PDE12 terminates these antiviral activities, leading to decreased resistance of cells for a variety of viral pathogens. Therefore inhibitors of PDE12 are discussed as antiviral therapy. Here we describe the use of the yttrium silicate SPA bead technology to assess inhibitory activity of compounds against PDE12 in a homogeneous, robust HTS feasible assay using tritiated adenosine-P-adenylate ([3H]ApA) as substrate. We found that the used [3H]ApA educt, was not able to bind to SPA beads, whereas the product [3H]AMP, as known before, was able to bind to SPA beads. This enables the measurement of PDE12 activity on [3H]ApA as a substrate using a wallac microbeta counter. This method describes a robust and high throughput capable format in terms of specificity, commonly used compound solvents, ease of detection and assay matrices. The method could facilitate the search for PDE12 inhibitors as antiviral compounds.

  5. Methods of estimating the state of the mechanisms of regulation of cardiac activity for girls 9-10 years of age during physical training aimed at developing endurance

    Directory of Open Access Journals (Sweden)

    Samokih I.I.

    2012-02-01

    Full Text Available Are considered indicators of regulation of cardiac activity proposed D.N. Davidenko et al. (1984. It is established age-related indicators in girls from 9 to 10 years. It is shown that in the process of double-entry physical training with the implementation of priority endurance exercise significantly improves the efficiency of regulation of cardiac activity for girls. The expediency of the lessons of physical culture directed on the priority of development endurance to improve the physical health of school girls of primary school.

  6. A calorimetric method to determine water activity.

    Science.gov (United States)

    Björklund, Sebastian; Wadsö, Lars

    2011-11-01

    A calorimetric method to determine water activity covering the full range of the water activity scale is presented. A dry stream of nitrogen gas is passed either over the solution whose activity should be determined or left dry before it is saturated by bubbling through water in an isothermal calorimeter. The unknown activity is in principle determined by comparing the thermal power of vaporization related to the gas stream with unknown activity to that with zero activity. Except for three minor corrections (for pressure drop, non-perfect humidification, and evaporative cooling) the unknown water activity is calculated solely based on the water activity end-points zero and unity. Thus, there is no need for calibration with references with known water activities. The method has been evaluated at 30 °C by measuring the water activity of seven aqueous sodium chloride solutions ranging from 0.1 mol kg(-1) to 3 mol kg(-1) and seven saturated aqueous salt solutions (LiCl, MgCl(2), NaBr, NaCl, KCl, KNO(3), and K(2)SO(4)) with known water activities. The performance of the method was adequate over the complete water activity scale. At high water activities the performance was excellent, which is encouraging as many other methods used for water activity determination have limited performance at high water activities. © 2011 American Institute of Physics

  7. Coincidence method for determination of radionuclides activities

    International Nuclear Information System (INIS)

    Andrukhovich, S.K.; Berestov, A.V.; Rudak, E.A.

    2004-01-01

    The radon and radium activity measurements using six-crystal gamma-gamma coincidence, 4 -spectrometer PRIPJAT and radioactivity measurements in different samples of meat and vegetation by 32-crystal spectrometer ARGUS, are described. Radiation detector with 4 -geometry provides higher efficiency, and therefore shorter counting time than a detector without such geometry. However, its application is limited by the fact that obtained spectrum contains summing peaks of all γ-quanta registered in coincidence. Multiparameter information on coincident photon emission can be obtained only by a detection system where the 4 -geometry is made by many detectors, such are both the PRIPJAT and the ARGUS - γ-coincidence spectrometer of the Crystal Ball type in the Institute of Physics, Minsk [1,2]. There are other characteristics, as background conditions, energy and time resolution, makes it ve suitable for investigation of rare decays and interactions, cascade transitions, k intensity radiations etc. We are developing a method of 2 26R a and 2 26 Rn measurement by a multidetector 4 -spectrometer. The method is based on coincidence counting of γ-rays from two step cascade transitions that follow - decay of 2 14 Bi. Its application to the PRIPL spectrometer, which has 6 Nal(Tl) detectors, is presented here, as well as the method of the determination of radionuclide activities based on the registration of the cascades intensity of γ-rays of different multiplicity using ARGUS

  8. Development of low-activation design method for reduction of radioactive waste (2). Precise neutron flux and activation estimation of nuclear power plants using MATXSLIB-J33T10

    International Nuclear Information System (INIS)

    Uematsu, Mikio; Hayashi, Katsumi; Nemezawa, Shigeki; Ogata, Tomohiro; Nakata, Mikihiro; Kinno, Masaharu; Yamaguchi, Katsuyoshi; Saito, Minoru; Hasegawa, Akira

    2008-01-01

    We have been developing low-activation concrete for biological shielding wall of nuclear power plants, for the purpose of reducing large amount of radioactive waste. Based on measurement of Eu and Co content in various aggregate candidates, limestone and electro-fused alumina were selected as the most feasible aggregate for low activation concrete. Induced activity in shielding wall was calculated for both low activation concrete and ordinary concrete using neutron flux obtained from DORT two-dimensional calculation made for typical ABWR and APWR models. We have prepared new cross section library named 'MATXSLIB-J33T10 that has multi-group structure in thermal energy. The library was processed from evaluated cross section library JENDL 3.3 by using NJOY 99.83. Activation cross section library for ORIGEN-79 code is prepared for each activation calculation case by collapsing JENDL-3.3 originated 183-group constants into 3-group activation cross section using 183-group neutron flux. One-group activation cross section was also prepared in the same manner for ORIGEN2 calculation. The ΣD/C value results for low-activation concrete was sufficiently low comparing to the ordinary concrete. By using the developed low-activation concrete, activation level of biological shielding wall concrete will be effectively decreased. The use of the developed low-activation concrete will contribute to economization of nuclear power plants decommissioning by reducing large amount of radioactive concrete waste. (author)

  9. Method Engineering: Engineering of Information Systems Development Methods and Tools

    NARCIS (Netherlands)

    Brinkkemper, J.N.; Brinkkemper, Sjaak

    1996-01-01

    This paper proposes the term method engineering for the research field of the construction of information systems development methods and tools. Some research issues in method engineering are identified. One major research topic in method engineering is discussed in depth: situational methods, i.e.

  10. METHODS TO DEVELOP A TOROIDAL SURFACE

    Directory of Open Access Journals (Sweden)

    DANAILA Ligia

    2017-05-01

    Full Text Available The paper work presents two practical methods to draw the development of a surface unable to be developed applying classical methods of Descriptive Geometry, the toroidal surface, frequently met in technical practice. The described methods are approximate ones; the development is obtained with the help of points. The accuracy of the methods is given by the number of points used when drawing. As for any other approximate method, when practically manufactured the development may need to be adjusted on site.

  11. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain

    2010-01-01

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed....

  12. Active teaching methods, studying responses and learning

    DEFF Research Database (Denmark)

    Christensen, Hans Peter; Vigild, Martin Etchells; Thomsen, Erik Vilain

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching.......Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching....

  13. Healthy kids out of school: using mixed methods to develop principles for promoting healthy eating and physical activity in out-of-school settings in the United States.

    Science.gov (United States)

    Sliwa, Sarah A; Sharma, Shanti; Dietz, William H; Dolan, Peter R; Nelson, Miriam E; Newman, Molly B; Rockeymoore, Maya; Economos, Christina D

    2014-12-31

    Widespread practices supporting availability of healthful foods, beverages, and physical activity in out-of-school-time (OST) settings would further obesity prevention efforts. The objective of this article was to describe principles to guide policy development in support of healthy eating and physical activity practices in out-of-school settings to promote obesity prevention. The Institute of Medicine's L.E.A.D. framework (Locate Evidence, Evaluate it, Assemble it, and Inform Decisions) was used to identify practices relevant to children's healthful eating in most OST settings: 1) locate and evaluate information from a national survey of children's perceptions of healthful-food access; published research, reports, policies and guidelines; and roundtables with OST organizations' administrators; 2) assemble information to prioritize actionable practices; and 3) inform programmatic direction. Three evidence-informed guiding principles for short-duration OST resulted: 1) drink right: choose water instead of sugar-sweetened beverages; 2) move more: boost movement and physical activity in all programs; and 3) snack smart: fuel up on fruits and vegetables. Healthy Kids Out of School was launched to support the dissemination and implementation of these guiding principles in short-duration OST settings, complementing efforts in other OST settings to shift norms around eating and physical activity.

  14. Scenario development methods and practice

    International Nuclear Information System (INIS)

    2001-01-01

    The safe management of radioactive waste is an essential aspect of all nuclear power programmes. Although a general consensus has been reached in OECD countries on the use of geological repositories for the disposal of high-level radioactive waste, analysis of the long-term safety of these repositories, using performance assessment and other tools, is required prior to implementation. The initial stage in developing a repository safety assessment is the identification of all factors that may be relevant to the long-term safety of the repository and their combination to form scenarios. This must be done in a systematic and transparent way in order to assure the regulatory authorities that nothing important has been forgotten. Scenario development has become the general term used to describe the collection and organisation of the scientific and technical information necessary to assess the long-term performance or safety of radioactive waste disposal systems. This includes the identification of the relevant features, events and processes (FEPs), the synthesis of broad models of scientific understanding, and the selection of cases to be calculated. Scenario development provides the overall framework in which the cases and their calculated consequences can be discussed, including biases or shortcomings due to omissions or lack of knowledge. The NEA Workshop on Scenario Development was organised in Madrid, in May 1999, with the objective of reviewing developments in scenario methodologies and applications in safety assessments since 1992. The outcome of this workshop is the subject of this book. It is a review of developments in scenario methodologies based on a large body of practical experience in safety assessments. It will be of interest to radioactive waste management experts as well as to other specialists involved in the development of scenario methodologies. (author)

  15. Methods of marketing and advertising activity evaluation

    Directory of Open Access Journals (Sweden)

    A.I. Yakovlev

    2016-09-01

    Full Text Available The result of the business entities’ activities is associated with the development of instruments of the economic processes efficiency determination, including marketing activities. It has determined the purpose of the article. The methodological principles in this area are developed. It is proved that the increase in sales of the profit margin is only partly dependent on the implementation of advertising measures. The methodical approaches for estimation of exhibition and advertising activity and promotion of its employees are specified. The results of work involve evaluation of the advertising effect value on the basis of share of the advertising impact on the increase of sales and revenue from the sale of products. The corresponding proportion of such impact is determined based on the consumer inquiry. The index of trade fair works, its calculation based on two components: how many times a specific company participated in such events; and how well the company was presented at relevant trade fairs. The indices of the cost on advertising and promotion of certain products manufacturer are provided. The scientific innovation of the research is as follows. It is proved that the sales increase effect should not be assigned to advertising only. The compositions that influence the consumer preferences and their share in the total value effect are determined. The new is the proposed index of influence of the trade fair work results depending on the selected factors. The practical importance of the research results involve more accurate calculation of the effect of the activities made and, consequently, increase efficiency of the business entities.

  16. Instrumental neutron activation analysis - a routine method

    International Nuclear Information System (INIS)

    Bruin, M. de.

    1983-01-01

    This thesis describes the way in which at IRI instrumental neutron activation analysis (INAA) has been developed into an automated system for routine analysis. The basis of this work are 20 publications describing the development of INAA since 1968. (Auth.)

  17. Development of a stability-indicating UPLC method for determining olanzapine and its associated degradation products present in active pharmaceutical ingredients and pharmaceutical dosage forms.

    Science.gov (United States)

    Krishnaiah, Ch; Vishnu Murthy, M; Kumar, Ramesh; Mukkanti, K

    2011-03-25

    A simple, sensitive and reproducible ultra performance liquid chromatography (UPLC) coupled with a photodiode array detector method was developed for the quantitative determination of olanzapine (OLN) in API and pharmaceutical dosage forms. The method is applicable to the quantification of related substances and assays of drug substances. Chromatographic separation was achieved on Acquity UPLC BEH 100-mm, 2.1-mm, and 1.7-μm C-18 columns, and the gradient eluted within a short runtime, i.e., within 10.0 min. The eluted compounds were monitored at 250 nm, the flow rate was 0.3 mL/min, and the column oven temperature was maintained at 27°C. The resolution of OLN and eight (potential, bi-products and degradation) impurities was greater than 2.0 for all pairs of components. The high correlation coefficient (r(2)>0.9991) values indicated clear correlations between the investigated compound concentrations and their peak areas within the test ranges. The repeatability and intermediate precision, expressed by the RSD, were less than 2.4%. The accuracy and validity of the method were further ascertained by performing recovery studies via a spike method. The accuracy of the method expressed as relative error was satisfactory. No interference was observed from concomitant substances normally added to the tablets. The drug was subjected to the International Conference on Harmonization (ICH)-prescribed hydrolytic, oxidative, photolytic and thermal stress conditions. The performance of the method was validated according to the present ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Ethnographic Contributions to Method Development

    DEFF Research Database (Denmark)

    Leander, Anna

    2016-01-01

    of IR—Critical Security Studies. Ethnographic research works with what has been termed a “strong” understanding of objectivity. When this understanding is taken seriously, it must lead to a refashioning of the processes of gathering, analyzing, and presenting data in ways that reverse many standard...... of research in the ethnographic tradition. However, it would also require rethinking standard methods instructions and the judgments they inform....... assumptions and instructions pertaining to “sound methods.” Both in the context of observation and in that of justification, working with “strong objectivity” requires a flexibility and willingness to shift research strategies that is at odds with the usual emphasis on stringency, consistency, and carefully...

  19. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott [Univ. of Washington, Seattle, WA (United States)

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  20. Developing Scoring Algorithms (Earlier Methods)

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  1. Taxonomic Dimensions for Studying Situational Method Development

    NARCIS (Netherlands)

    Aydin, Mehmet N.; Harmsen, Frank; van Hillegersberg, Jos; Ralyté, Jolita; Brinkkemper, Sjaak; Henderson-Sellers, Brian

    2007-01-01

    This paper is concerned with fragmented literature on situational method development, which is one of fundamental topics related to information systems development (ISD) methods. As the topic has attracted many scholars from various and possibly complementary schools of thought, different

  2. Method Engineering: Engineering of Information Systems Development Methods and Tools

    OpenAIRE

    Brinkkemper, J.N.; Brinkkemper, Sjaak

    1996-01-01

    This paper proposes the term method engineering for the research field of the construction of information systems development methods and tools. Some research issues in method engineering are identified. One major research topic in method engineering is discussed in depth: situational methods, i.e. the configuration of a project approach that is tuned to the project at hand. A language and support tool for the engineering of situational methods are discussed.

  3. Developments in geophysical exploration methods

    CERN Document Server

    1982-01-01

    One of the themes in current geophysical development is the bringing together of the results of observations made on the surface and those made in the subsurface. Several benefits result from this association. The detailed geological knowledge obtained in the subsurface can be extrapolated for short distances with more confidence when the geologi­ cal detail has been related to well-integrated subsurface and surface geophysical data. This is of value when assessing the characteristics of a partially developed petroleum reservoir. Interpretation of geophysical data is generally improved by the experience of seeing the surface and subsurface geophysical expression of a known geological configuration. On the theoretical side, the understanding of the geophysical processes themselves is furthered by the study of the phenomena in depth. As an example, the study of the progress of seismic wave trains downwards and upwards within the earth has proved most instructive. This set of original papers deals with some of ...

  4. ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: MODELING

    Directory of Open Access Journals (Sweden)

    Brînduşa-Antonela SBÎRCEA

    2011-01-01

    Full Text Available By using active and participatory methods it is hoped that pupils will not only come to a deeper understanding of the issues involved, but also that their motivation will be heightened. Pupil involvement in their learning is essential. Moreover, by using a variety of teaching techniques, we can help students make sense of the world in different ways, increasing the likelihood that they will develop a conceptual understanding. The teacher must be a good facilitator, monitoring and supporting group dynamics. Modeling is an instructional strategy in which the teacher demonstrates a new concept or approach to learning and pupils learn by observing. In the teaching of biology the didactic materials are fundamental tools in the teaching-learning process. Reading about scientific concepts or having a teacher explain them is not enough. Research has shown that modeling can be used across disciplines and in all grade and ability level classrooms. Using this type of instruction, teachers encourage learning.

  5. Forms and Methods of Agricultural Sector Innovative Activity Improvement

    Directory of Open Access Journals (Sweden)

    Aisha S. Ablyaeva

    2013-01-01

    Full Text Available The article is focused on basic forms and methods to improve the efficiency of innovative activity in the agricultural sector of Ukraine. It was determined that the development of agriculture in Ukraine is affected by a number of factors that must be considered to design innovative models of entrepreneurship development and ways to improve the efficiency of innovative entrepreneurship activity.

  6. Nuclear methods in national development

    International Nuclear Information System (INIS)

    1993-01-01

    This volume of the proceedings of the First National Conference on Nuclear Methods held at Kongo Conference Hotel Zaria from 2-4 September 1993, contains the full text of about 30 technical papers and speeches of invited dignitaries presented at the conference. The technical papers are original or review articles containing results and experiences in nuclear and related analytical techniques. Topics treated include neutron generator operation and control, nuclear data, application of nuclear techniques in environment, geochemistry, medicine, biology, agriculture, material science and industries. General topics in nuclear laboratory organization and research experiences were also covered. The papers were fully discussed during the conference and authors were requested to make changes in the manuscripts where necessary. However, they were further edited. The organizing committee wishes to thank all authors for their presentation and cooperation in submitting their manuscripts promptly and the participants for their excellent contribution during the conference

  7. Development of a technique using MCNPX code for determination of nitrogen content of explosive materials using prompt gamma neutron activation analysis method

    Energy Technology Data Exchange (ETDEWEB)

    Nasrabadi, M.N., E-mail: mnnasrabadi@ast.ui.ac.ir [Department of Nuclear Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan 81746-73441 (Iran, Islamic Republic of); Bakhshi, F.; Jalali, M.; Mohammadi, A. [Department of Nuclear Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan 81746-73441 (Iran, Islamic Republic of)

    2011-12-11

    Nuclear-based explosive detection methods can detect explosives by identifying their elemental components, especially nitrogen. Thermal neutron capture reactions have been used for detecting prompt gamma 10.8 MeV following radioactive neutron capture by {sup 14}N nuclei. We aimed to study the feasibility of using field-portable prompt gamma neutron activation analysis (PGNAA) along with improved nuclear equipment to detect and identify explosives, illicit substances or landmines. A {sup 252}Cf radio-isotopic source was embedded in a cylinder made of high-density polyethylene (HDPE) and the cylinder was then placed in another cylindrical container filled with water. Measurements were performed on high nitrogen content compounds such as melamine (C{sub 3}H{sub 6}N{sub 6}). Melamine powder in a HDPE bottle was placed underneath the vessel containing water and the neutron source. Gamma rays were detected using two NaI(Tl) crystals. The results were simulated with MCNP4c code calculations. The theoretical calculations and experimental measurements were in good agreement indicating that this method can be used for detection of explosives and illicit drugs.

  8. METHOD OF SUPPRESSING GASTROINTESTINAL UREASE ACTIVITY

    Science.gov (United States)

    Visek, W.J.

    1963-04-23

    This patent shows a method of increasing the growth rate of chicks. Certain diacyl substituted ureas such as alloxan, murexide, and barbituric acid are added to their feed, thereby suppressing gastrointestinal urease activity and thus promoting growth. (AEC)

  9. Activating teaching methods, studying responses and learning

    OpenAIRE

    Christensen, Hans Peter; Vigild, Martin E.; Thomsen, Erik; Szabo, Peter; Horsewell, Andy

    2009-01-01

    Students’ study strategies when exposed to activating teaching methods are measured, analysed and compared to study strategies in more traditional lecture-based teaching. The resulting learning outcome is discussed. Peer Reviewed

  10. Shielding methods development in the United States

    International Nuclear Information System (INIS)

    Mynatt, F.R.

    1977-01-01

    A generalized shielding methodology has been developed in the U.S.A. that is adaptable to the shielding analyses of all reactor types. Thus far used primarily for liquid-metal fast breeder reactors, the methodology includes several component activities: (1) developing methods for calculating radiation transport through reactor-shield systems; (2) processing cross-section libraries; (3) performing design calculations for specific systems; (4) performing and analyzing pertinent integral experiments; (5) performing sensitivity studies on both the design calculations and the experimental analyses; and, finally, (6) calculating shield design parameters and their uncertainties. The criteria for the methodology are a 5 to 10 percent accuracy for responses at locations near the core and a factor of 2 accuracy for responses at distant locations. The methodology has been successfully adapted to most in-vessel and ex-vessel problems encountered in the shield analyses of the Fast Flux Test Facility and the Fast Flux Test Facility and the Clinch River Breeder Reactor; however, improved techniques are needed for calculating regions in which radiation streaming is dominant. Areas of the methodology in which significant progress has recently been made are those involving the development of cross-section libraries, sensitivity analysis methods, and transport codes

  11. Methods and Software Architecture for Activity Recognition from Position Data

    DEFF Research Database (Denmark)

    Godsk, Torben

    This thesis describes my studies on the subject of recognizing cow activities from satellite based position data. The studies comprise methods and software architecture for activity recognition from position data, applied to cow activity recognition. The development of methods and software....... The results of these calculations are applied to a given standard machine learning algorithm, and the activity, performed by the cow as the measurements were recorded, is recognized. The software architecture integrates these methods and ensures flexible activity recognition. For instance, it is flexible...... in relation to the use of different sensors modalities and/or within different domains. In addition, the methods and their integration with the software architecture ensures both robust and accurate activity recognition. Utilized, it enables me to classify the five activities robustly and with high success...

  12. Reactor physics methods development at Westinghouse

    International Nuclear Information System (INIS)

    Mueller, E.; Mayhue, L.; Zhang, B.

    2007-01-01

    The current state of reactor physics methods development at Westinghouse is discussed. The focus is on the methods that have been or are under development within the NEXUS project which was launched a few years ago. The aim of this project is to merge and modernize the methods employed in the PWR and BWR steady-state reactor physics codes of Westinghouse. (author)

  13. IoT System Development Methods

    NARCIS (Netherlands)

    Giray, G.; Tekinerdogan, B.; Tüzün, E.

    2018-01-01

    It is generally believed that the application of methods plays an important role in developing quality systems. A development method is mainly necessary for structuring the process in producing largescale and complex systems that involve high costs. Similar to the development of other systems, it is

  14. Development of Dissolution Test Method for Drotaverine ...

    African Journals Online (AJOL)

    Development of Dissolution Test Method for Drotaverine ... Methods: Sink conditions, drug stability and specificity in different dissolution media were tested to optimize a dissolution test .... test by Prism 4.0 software, and differences between ...

  15. Moral counselling: a method in development.

    Science.gov (United States)

    de Groot, Jack; Leget, Carlo

    2011-01-01

    This article describes a method of moral counselling developed in the Radboud University Medical Centre Nijmegen (The Netherlands). The authors apply insights of Paul Ricoeur to the non-directive counselling method of Carl Rogers in their work of coaching patients with moral problems in health care. The developed method was shared with other health care professionals in a training course. Experiences in the course and further practice led to further improvement of the method.

  16. Using containerless methods to develop amorphous pharmaceuticals.

    Science.gov (United States)

    Weber, J K R; Benmore, C J; Suthar, K J; Tamalonis, A J; Alderman, O L G; Sendelbach, S; Kondev, V; Yarger, J; Rey, C A; Byrn, S R

    2017-01-01

    Many pipeline drugs have low solubility in their crystalline state and require compounding in special dosage forms to increase bioavailability for oral administration. The use of amorphous formulations increases solubility and uptake of active pharmaceutical ingredients. These forms are rapidly gaining commercial importance for both pre-clinical and clinical use. Synthesis of amorphous drugs was performed using an acoustic levitation containerless processing method and spray drying. The structure of the products was investigated using in-situ high energy X-ray diffraction. Selected solvents for processing drugs were investigated using acoustic levitation. The stability of amorphous samples was measured using X-ray diffraction. Samples processed using both spray drying and containerless synthesis were compared. We review methods for making amorphous pharmaceuticals and present data on materials made by containerless processing and spray drying. It was shown that containerless processing using acoustic levitation can be used to make phase-pure forms of drugs that are known to be difficult to amorphize. The stability and structure of the materials was investigated in the context of developing and making clinically useful formulations. Amorphous compounds are emerging as an important component of drug development and for the oral delivery of drugs with low solubility. Containerless techniques can be used to efficiently synthesize small quantities of pure amorphous forms that are potentially useful in pre-clinical trials and for use in the optimization of clinical products. Developing new pharmaceutical products is an essential enterprise to improve patient outcomes. The development and application of amorphous pharmaceuticals to increase absorption is rapidly gaining importance and it provides opportunities for breakthrough research on new drugs. There is an urgent need to solve problems associated with making formulations that are both stable and that provide high

  17. Recent development in thermally activated desalination methods: achieving an energy efficiency less than 2.5 kWhelec/m3

    KAUST Repository

    Shahzad, Muhammad Wakil

    2015-05-19

    Water-Energy-Environment nexus is a crucial consideration when designing seawater desalination processes, particularly for the water-stressed countries where the annual water availability is less than 250 m3 per capita. Despite the thermodynamics limit for seawater desalination at normal conditions is about 0.78 to 1.09 kWhelec/m3, the specific energy consumption of desalination of real plants is found to operate at several folds higher. Today’s technological advancement in membranes, namely the reverse osmosis processes, has set an energy consumption of around 3.5–5 kWhelec/m3, while the conventional perception of thermally activated processes such as MSF and MED tends to be higher. Although the higher energetic specific consumption of MED or MSF processes appeared to be higher at 60–100 kWhthermal/m3, their true electricity equivalent has been converted, hitherto, using the energetic analyses where the work potential of working steam of the processes cannot be captured adequately. Thermally activated processes, such as MED and MSF, form the bottoming cycle of a cogeneration plant where both electricity and desalination processes operate in tandem in a cascaded manner. Only the bled-steam at lower exergy is extracted for the desalination processes. In this presentation, we demonstrate that in a cogen plant with 30% bled-steam for MED processes, the exergy destruction ratio is found to be less than 7% of the total available exergy that emanated from the boilers. By the exergetic approach, the equivalent electricity consumption of an average 75 kWhthermal/m3 would result in an electrical equivalent of less than 2.5 kWhelec/m3. Also in this presentation, the authors will elaborate the latest developments in the use of hybridization concept where the MED and the AD cycles are thermodynamically integrated and enhancing the overall efficiency of desalination. © 2015 Balaban Desalination Publications. All rights reserved.

  18. A Review of Human Activity Recognition Methods

    Directory of Open Access Journals (Sweden)

    Michalis eVrigkas

    2015-11-01

    Full Text Available Recognizing human activities from video sequences or still images is a challenging task due to problems such as background clutter, partial occlusion, changes in scale, viewpoint, lighting, and appearance. Many applications, including video surveillance systems, human-computer interaction, and robotics for human behavior characterization, require a multiple activity recognition system. In this work, we provide a detailed review of recent and state-of-the-art research advances in the field of human activity classification. We propose a categorization of human activity methodologies and discuss their advantages and limitations. In particular, we divide human activity classification methods into two large categories according to whether they use data from different modalities or not. Then, each of these categories is further analyzed into sub-categories, which reflect how they model human activities and what type of activities they are interested in. Moreover, we provide a comprehensive analysis of the existing, publicly available human activity classification datasets and examine the requirements for an ideal human activity recognition dataset. Finally, we report the characteristics of future research directions and present some open issues on human activity recognition.

  19. Active and passive cooling methods for dwellings

    DEFF Research Database (Denmark)

    Oropeza-Perez, Ivan; Østergaard, Poul Alberg

    2018-01-01

    In this document a review of three active as well as ten passive cooling methods suitable for residential buildings is carried out. The review firstly addresses how the various technologies cool the space according to the terms of the building heat balance, under what technical conditions...... ventilation, controlled ventilation, roof coating and eco-evaporative cooling are the most suitable passive methods for an extensive use in this country....

  20. Neutron activation analysis: recent developments and applications

    International Nuclear Information System (INIS)

    Acharya, R.; Reddy, A.V.R.

    2012-01-01

    Neutron activation analysis (NAA) is a powerful isotope specific nuclear analytical technique for simultaneous determination of major to trace elemental concentrations in diverse matrices. NAA is associated with high analytical sensitivities and low detection limits (ppm to ppb) due to utilization of high neutron flux from research reactors and high efficiency high resolution gamma ray spectrometry. Elemental concentrations are determined either by conventional NAA using relative method or by single comparator method of NAA (k 0 -NAA). Since 1994, Radiochemistry Division is actively engaged in developments and applications of k 0 -based NAA and Prompt Gamma ray NAA (PGNAA) methods for compositional characterization of materials, in addition to conventional instrumental NAA (INAA) and chemical NAA (CNAA) methods for total as well as speciation studies. The article briefly summarizes developments of k 0 based method of NAA using an external single comparator (k 0 -NAA) and an internal monostandard (lM-NAA) and PGNAA and their applications to small as well as large size samples. The article also briefly highlights the application of INAA and chemical NAA (CNAA) for speciation studies of arsenic and iodine in environmental and food samples respectively and bioaccesibility of selenium in food samples and trace elements wheatgrass samples

  1. Methodology for developing new test methods

    Directory of Open Access Journals (Sweden)

    A. I. Korobko

    2017-06-01

    Full Text Available The paper describes the methodology for developing new test methods and forming solutions for the development of new test methods. The basis of the methodology for developing new test methods is the individual elements of the system and process approaches. They contribute to the development of an effective research strategy for the object, the study of interrelations, the synthesis of an adequate model of the test method. The effectiveness of the developed test method is determined by the correct choice of the set of concepts, their interrelations and mutual influence. This allows you to solve the tasks assigned to achieve the goal. The methodology is based on the use of fuzzy cognitive maps. The question of the choice of the method on the basis of which the model for the formation of solutions is based is considered. The methodology provides for recording a model for a new test method in the form of a finite set of objects. These objects are significant for the test method characteristics. Then a causal relationship is established between the objects. Further, the values of fitness indicators and the observability of the method and metrological tolerance for the indicator are established. The work is aimed at the overall goal of ensuring the quality of tests by improving the methodology for developing the test method.

  2. The SIESTA method; developments and applicability

    International Nuclear Information System (INIS)

    Artacho, Emilio; Anglada, E; Dieguez, O; Gale, J D; Garcia, A; Junquera, J; Martin, R M; Ordejon, P; Pruneda, J M; Sanchez-Portal, D; Soler, J M

    2008-01-01

    Recent developments in and around the SIESTA method of first-principles simulation of condensed matter are described and reviewed, with emphasis on (i) the applicability of the method for large and varied systems (ii) efficient basis sets for the standards of accuracy of density-functional methods (iii) new implementations, and (iv) extensions beyond ground-state calculations

  3. Some problems on Monte Carlo method development

    International Nuclear Information System (INIS)

    Pei Lucheng

    1992-01-01

    This is a short paper on some problems of Monte Carlo method development. The content consists of deep-penetration problems, unbounded estimate problems, limitation of Mdtropolis' method, dependency problem in Metropolis' method, random error interference problems and random equations, intellectualisation and vectorization problems of general software

  4. Active sound reduction system and method

    NARCIS (Netherlands)

    2016-01-01

    The present invention refers to an active sound reduction system and method for attenuation of sound emitted by a primary sound source, especially for attenuation of snoring sounds emitted by a human being. This system comprises a primary sound source, at least one speaker as a secondary sound

  5. Monte Carlo method in neutron activation analysis

    International Nuclear Information System (INIS)

    Majerle, M.; Krasa, A.; Svoboda, O.; Wagner, V.; Adam, J.; Peetermans, S.; Slama, O.; Stegajlov, V.I.; Tsupko-Sitnikov, V.M.

    2009-01-01

    Neutron activation detectors are a useful technique for the neutron flux measurements in spallation experiments. The study of the usefulness and the accuracy of this method at similar experiments was performed with the help of Monte Carlo codes MCNPX and FLUKA

  6. Methods for using polypeptides having cellobiohydrolase activity

    Science.gov (United States)

    Morant, Marc D; Harris, Paul

    2016-08-23

    The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  7. Analysis of Precision of Activation Analysis Method

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Nørgaard, K.

    1973-01-01

    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T...

  8. Evaluation of methods to assess physical activity

    Science.gov (United States)

    Leenders, Nicole Y. J. M.

    Epidemiological evidence has accumulated that demonstrates that the amount of physical activity-related energy expenditure during a week reduces the incidence of cardiovascular disease, diabetes, obesity, and all-cause mortality. To further understand the amount of daily physical activity and related energy expenditure that are necessary to maintain or improve the functional health status and quality of life, instruments that estimate total (TDEE) and physical activity-related energy expenditure (PAEE) under free-living conditions should be determined to be valid and reliable. Without evaluation of the various methods that estimate TDEE and PAEE with the doubly labeled water (DLW) method in females there will be eventual significant limitations on assessing the efficacy of physical activity interventions on health status in this population. A triaxial accelerometer (Tritrac-R3D, (TT)), an uniaxial (Computer Science and Applications Inc., (CSA)) activity monitor, a Yamax-Digiwalker-500sp°ler , (YX-stepcounter), by measuring heart rate responses (HR method) and a 7-d Physical Activity Recall questionnaire (7-d PAR) were compared with the "criterion method" of DLW during a 7-d period in female adults. The DLW-TDEE was underestimated on average 9, 11 and 15% using 7-d PAR, HR method and TT. The underestimation of DLW-PAEE by 7-d PAR was 21% compared to 47% and 67% for TT and YX-stepcounter. Approximately 56% of the variance in DLW-PAEE*kgsp{-1} is explained by the registration of body movement with accelerometry. A larger proportion of the variance in DLW-PAEE*kgsp{-1} was explained by jointly incorporating information from the vertical and horizontal movement measured with the CSA and Tritrac-R3D (rsp2 = 0.87). Although only a small amount of variance in DLW-PAEE*kgsp{-1} is explained by the number of steps taken per day, because of its low cost and ease of use, the Yamax-stepcounter is useful in studies promoting daily walking. Thus, studies involving the

  9. Prognostic aspects of imaging method development

    International Nuclear Information System (INIS)

    Steinhart, L.

    1987-01-01

    A survey is presented of X-ray diagnostic methods and techniques and possibilities of their further development. Promising methods include direct imaging using digital radiography. In connection with computer technology these methods achieve higher resolution. The storage of obtained images in the computer memory will allow automated processing and evaluation and the use of expert systems. Development is expected to take place especially in computerized tomography using magnetic resonance, and positron computed tomography and other non-radioactive diagnostic methods. (J.B.). 5 figs., 1 tab., 1 ref

  10. Optimization Methods for Supply Chain Activities

    Directory of Open Access Journals (Sweden)

    Balasescu S.

    2014-12-01

    Full Text Available This paper approach the theme of supply chain activities for medium and large companies which run many operations and need many facilities. The first goal is to analyse the influence of optimisation methods of supply chain activities on the success rate for a business. The second goal is to compare some logistic strategies applied by companies with the same profile to see which is the most effective. The final goal is to show which is the necessity of strategic optimum for a company and how can be achieved the considering the demand uncertainty.

  11. Prospects of development of innovative activity

    Directory of Open Access Journals (Sweden)

    S. N. Zhuravleva

    2017-01-01

    Full Text Available The transition to a market economy requires a significant increase in production flexibility and receptivity to innovations. Newly created enterprises of knowledge-intensive sectors, in contrast to the conventional focus on full cycle, including the stage of R & d and production of new products and services. Innovations link the different character and methods of management activity: science, production, investment, sales. The improvement of the styles and techniques of innovation management, quick and adequate response to changing market conditions, the development of new lines of instruments in the companies, etc. allow the innovators to use all kinds of resources for successful innovation. In recent years Russia has made a serious step towards innovative development to a greater extent by providing a system for encouraging innovation and technological development of sectors of the economy. Active development and modernization of technology, introduction of various technological projects is one of the driving forces of the innovation process. That is why the creation of new, unique cutting-edge production technologies is an important element of innovative development of the economy. And as shown by the forecast values, the prospects for development in this area is very high. However, many domestic enterprises follow the «conservative» paths of development, the essence of which is to maximize the preservation of existing company structures, technology of production, even in the transition to the new generation of products. Such a scenario for many years preserves the situation of backwardness of the domestic industry from the leading countries of the West. The way out of this situation - a complete overhaul of the company based on innovation. Therefore, the development of industrial design is one of the main stimulating factors of innovative development of Russia. Be aware that the development of the innovation sector through which progress

  12. Developing Internal Controls through Activities

    Science.gov (United States)

    Barnes, F. Herbert

    2009-01-01

    Life events can include the Tuesday afternoon cooking class with the group worker or the Saturday afternoon football game, but in the sense that Fritz Redl thought of them, these activities are only threads in a fabric of living that includes all the elements of daily life: playing, working, school-based learning, learning through activities,…

  13. Neutron activation analysis: principle and methods

    International Nuclear Information System (INIS)

    Reddy, A.V.R.; Acharya, R.

    2006-01-01

    Neutron activation analysis (NAA) is a powerful isotope specific nuclear analytical technique for simultaneous determination of elemental composition of major, minor and trace elements in diverse matrices. The technique is capable of yielding high analytical sensitivity and low detection limits (ppm to ppb). Due to high penetration power of neutrons and gamma rays, NAA experiences negligible matrix effects in the samples of different origins. Depending on the sample matrix and element of interest NAA technique is used non-destructively, known as instrumental neutron activation analysis (INAA), or through chemical NAA methods. The present article describes principle of NAA, different methods and gives a overview some applications in the fields like environment, biology, geology, material sciences, nuclear technology and forensic sciences. (author)

  14. An active role for machine learning in drug development

    Science.gov (United States)

    Murphy, Robert F.

    2014-01-01

    Due to the complexity of biological systems, cutting-edge machine-learning methods will be critical for future drug development. In particular, machine-vision methods to extract detailed information from imaging assays and active-learning methods to guide experimentation will be required to overcome the dimensionality problem in drug development. PMID:21587249

  15. Method to produce catalytically active nanocomposite coatings

    Science.gov (United States)

    Erdemir, Ali; Eryilmaz, Osman Levent; Urgen, Mustafa; Kazmanli, Kursat

    2016-02-09

    A nanocomposite coating and method of making and using the coating. The nanocomposite coating is disposed on a base material, such as a metal or ceramic; and the nanocomposite consists essentially of a matrix of an alloy selected from the group of Cu, Ni, Pd, Pt and Re which are catalytically active for cracking of carbon bonds in oils and greases and a grain structure selected from the group of borides, carbides and nitrides.

  16. Method to produce catalytically active nanocomposite coatings

    Energy Technology Data Exchange (ETDEWEB)

    Erdemir, Ali; Eryilmaz, Osman Levent; Urgen, Mustafa; Kazmanli, Kursat

    2017-12-19

    A nanocomposite coating and method of making and using the coating. The nanocomposite coating is disposed on a base material, such as a metal or ceramic; and the nanocomposite consists essentially of a matrix of an alloy selected from the group of Cu, Ni, Pd, Pt and Re which are catalytically active for cracking of carbon bonds in oils and greases and a grain structure selected from the group of borides, carbides and nitrides.

  17. Development of spectrophotometric fingerprinting method for ...

    African Journals Online (AJOL)

    Selective and efficient analytical methods are required not only for quality assurance but also for authentication of herbal formulations. A simple, rapid and validated fingerprint method has developed for estimation of piperine in 'Talisadi churna', a well known herbal formulation in India. The estimation was carried out in two ...

  18. Validated modified Lycopodium spore method development for ...

    African Journals Online (AJOL)

    Validated modified lycopodium spore method has been developed for simple and rapid quantification of herbal powdered drugs. Lycopodium spore method was performed on ingredients of Shatavaryadi churna, an ayurvedic formulation used as immunomodulator, galactagogue, aphrodisiac and rejuvenator. Estimation of ...

  19. Development of Three Methods for Simultaneous Quantitative ...

    African Journals Online (AJOL)

    Development of Three Methods for Simultaneous Quantitative Determination of Chlorpheniramine Maleate and Dexamethasone in the Presence of Parabens in ... Tropical Journal of Pharmaceutical Research ... Results: All the proposed methods were successfully applied to the analysis of raw materials and dosage form.

  20. Development and Application of Kinetic Spectrophotometric Method ...

    African Journals Online (AJOL)

    Purpose: To develop an improved kinetic-spectrophotometric procedure for the determination of metronidazole (MNZ) in pharmaceutical formulations. Methods: The method is based on oxidation reaction of MNZ by hydrogen peroxide in the presence of Fe(II) ions at pH 4.5 (acetate buffer). The reaction was monitored ...

  1. Methods of charged-particle activation analysis

    International Nuclear Information System (INIS)

    Chaudhri, M. Anwar; Chaudhri, M. Nasir; Jabbar, Q.; Nadeem, Q.

    2006-01-01

    The accuracy of Chaudhri's method for charged-particle activation analysis published in J. Radioanal. Chem. (1977) v. 37 p. 243 has been further demonstrated by extensive calculations. The nuclear reactions 12 C(d,n) 13 N, 63 Cu( 3 He,p) 65 Zn, 107 Ag(α,n) 110 In and 208 Pb(d,p) 209 Pb, the cross sections of which were easily available, have been examined for the detection of 12 C, 63 Cu, 107 Ag and 208 Pb, respectively, in matrices of Cu, Zr and Pb, at the bombarding energies of 4 - 22 MeV. The 'standard' is assumed to be in a carbon matrix. It has been clearly demonstrated that Chaudhri's method, which makes the charged particle activation analysis as simple as neutron activation analysis, provides results which are almost identical to, or only about 1-2 % different, from the results obtained using the full 'Activity Equation' involving solving complex integrals. It is valid even when the difference in the average atomic weights of matrices of the standard and the sample is large. (author)

  2. Inventive activity of the Department of Protein Structure and Function of the Palladin Institute of Biochemistry of NAS of Ukraine. Part I. Development of the diagnostic methods for detection of hemostasis disorders and characterization of certain blood coagulation factors

    Directory of Open Access Journals (Sweden)

    V. M. Danilova

    2016-04-01

    Full Text Available The practical aspects of inventive activity of the Department of Protein Structure and Function of the Palladin Institute of Biochemistry, NAS of Ukraine are highlighted in this article. Through years of fundamental and applied researches of blood coagulation system proteins, initiated by luminaries of the world biochemistry O. V. Palladin and V. O. Belitser, the Department staff have developed a considerable number of methods, techniques and tests for the assessment of the state of the hemostasis system, which were approved in many clinics. In the first part of this work the authors describe the development of the diagnostic methods for identifying the homeostasis system disorders in detail, as well as characterize certain coagulation factors.

  3. Development of an analytical method coupling cell membrane chromatography with gas chromatography-mass spectrometry via microextraction by packed sorbent and its application in the screening of volatile active compounds in natural products.

    Science.gov (United States)

    Li, Miao; Wang, Sicen; He, Langchong

    2015-01-01

    Natural products (NPs) are important sources of lead compounds in modern drug discovery. To facilitate the screening of volatile active compounds in NPs, we have developed a new biochromatography method that uses rat vascular smooth muscle cells (VSMC), which are rich in L-type calcium channels (LCC), to prepare the stationary phase. This integrated method, which couples cell membrane chromatography (CMC) with gas chromatography-mass spectrometry (GC-MS) via microextraction by packed sorbent (MEPS) technology, has been termed VSMC/CMC-MEPS-GC-MS. Methodological validation confirmed its specificity, reliability and convenience. Screening results for Radix Angelicae Dahuricae and Fructus Cnidii obtained using VSMC/CMC-MEPS-GC-MS were consistent with those obtained using VSMC/CMC-offline-GC-MS. MEPS connection plays as simplified solid-phase extraction and replaces the uncontrollable evaporation operation in reported offline connections, so our new method is supposed to be more efficient and reliable than the offline ones, especially for compounds that are volatile, thermally unstable or difficult to purify. In application, senkyunolide A and ligustilide were preliminary identified as the volatile active components in Rhizoma Chuanxiong. We have thus confirmed the suitability of VSMC/CMC-MEPS-GC-MS for volatile active compounds screening in NP. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. TRANSFORMATION OF INNOVATIVE AND METHODICAL ACTIVITY LIBRARY OF THE UNIVERSITY

    Directory of Open Access Journals (Sweden)

    О. О. Скаченко

    2015-09-01

    Full Text Available The purpose of our article is the analysis of innovative and methodical activity of university libraries which develop as information centers today. The subject of research is methodical, publishing and innovative activity of Scientific Library of the Kiev national university of culture and arts. We observe process of introduction of technological innovations in library service that allows improving quality of the services provided to the reader by library. New actual projects are developed, cultural and educational and information services extend, work methods improve. Also, the structure of library is improved – there are new sectors. The main finding of the work consists in systematization of various aspects and the directions of innovative activity of library. The research findings have the practical value for library workers, teachers of university, students, library users, and also for anyone who is interested in library science.

  5. Development of methods for activity determination for radionuclides with double decay emission β- β+ / electron capture - application to the standardization of 192Ir, 152Eu and 186 Re

    International Nuclear Information System (INIS)

    Hilario, Katia Aparecida Fonseca

    2002-01-01

    In the present work alternative procedures have been developed for standardization of radionuclides with double decay, β - β + / electron capture using the 4πβ-γ coincidence technique, applying different systems. Two 4πβ-γ coincidence systems were used: one with a 4π gas-flow proportional counter coupled to a pair of NaI(Tl) scintillators and the other one with the same type of proportional counter coupled to HPGe detector. The radionuclides selected for this standardization, due to great interest in nuclear medicine, detector calibration and industrial radiography, were 192 Ir, 152 Eu and 186 Re. The first and the second were part of international comparisons sponsored by the Bureau International des Poids et Mesures (BIPM), France, who supplied the radioactive solution. For 186 Re, the gamma-ray emission probability per decay was measured by means REGe spectrometer system, previously calibrated with standard ampoules. All the uncertainties involved were treated rigorously, by means of covariance analysis. (author)

  6. Development of radiometric methods for the determination of enzyme activities of iodothyronine deiodinases. Effect of the antidepressant fluoxetine on type 1, 2 and 3 deiodinase activities in the rat brain

    International Nuclear Information System (INIS)

    Pavelka, Stanislav

    2010-01-01

    The objectives of the present study were to establish valid assay conditions for measurement of the types 1, 2, and 3 (Dl, D2, and D3, respectively) iodothyronine deiodinases (IDs) activities, and to use the radiometric enzyme assays especially to follow the effects of antidepressant drug fluoxetine (Prozac) on the metabolism of thyroid hormones (TH) in the rat. In particular, the effects of subchronic administration of fluoxetine alone and in combination with 3,5,3'-triiodothyronine (T 3 ) on T 3 production and degradation in the CNS and peripheral tissues were investigated. The newly developed radiometric enzyme assays for IDs, based on the use of preferred 125 I-labeled iodothyronines as substrates, TLC separation of radioactive products from the unconsumed substrates, film-less autoradiography of radiochromatograms using storage phosphor screens, and quantification of the separated compounds with the BAS-5000 laser scanner, proved to be very sensitive and rapid and, at the same time, reliable and robust. (author)

  7. Activities in the Dynamic Occupational Therapy Method

    Directory of Open Access Journals (Sweden)

    Jô Benetton

    2013-12-01

    Full Text Available This paper addresses the concept and use of the instrument named ‘activities’ in occupational therapy, sustained by the propositions of the Dynamic Occupational Therapy Method (DOTM. Initially, we present general aspects related to the activities in the DOTM such as the option for the name ‘activities’, its conceptual definition, use as a tool, and active participation in the dynamic of triadic relationship. Further, it approaches the character of activities: therapeutic, educational and social qualities, which distinguish this peculiar occupational therapy. Moreover, the paper highlights the use of activities as a tool, both as a central element of the processes that should underpin clinical reasoning (observation, information, association, setting up space of historicity, and construction of narrative, and as an element belonging to diagnostic procedures, to the course of clinical process, and to evaluation. Finally, we present our understanding of what we call resources in DOTM, and its intrinsic connection with the possibility of performing ‘activities’. For the creation of DOTM, occupational therapy, as a practice focused on the uniqueness of the case, was made the object of study in order to promote knowledge construction. The conceptual and instrumental framework presented in this work held this effort. We hope that this study could be useful for initial and continuing training in Occupational Therapy as well as for enriching the debate on the use of ‘activities’ in our profession.

  8. Dual stage active magnetic regenerator and method

    Science.gov (United States)

    Pecharsky, Vitalij K.; Gschneidner, Jr., Karl A.

    1999-03-30

    A dual stage active magnetic regenerator refrigerator as well as method using the Joule-Brayton thermodynamic cycle includes a high temperature stage refrigerant comprising DyAl.sub.2 or (Dy.sub.1-x Er.sub.x)Al.sub.2 where x is selected to be greater than 0 and less than about 0.3 in combination with a low temperature stage comprising (Dy.sub.1-x Er.sub.x)Al.sub.2 where x is selected to be greater than about 0.5 and less than 1 to provide significantly improved refrigeration efficiency in the liquefaction of gaseous hydrogen.

  9. Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development.

    Science.gov (United States)

    Magotra, Asmita; Sharma, Anjna; Gupta, Ajai Prakash; Wazir, Priya; Sharma, Shweta; Singh, Parvinder Pal; Tikoo, Manoj Kumar; Vishwakarma, Ram A; Singh, Gurdarshan; Nandi, Utpal

    2017-08-15

    In the present study, a simple, sensitive, specific and rapid liquid chromatography (LC) tandem mass spectrometry (MS/MS) method was developed and validated according to the Food and Drug Administration (FDA) guidelines for estimation of IIIM-MCD-211 (a potent oral candidate with promising action against tuberculosis) in mice plasma using carbamazepine as internal standard (IS). Bioanalytical method consisted of one step protein precipitation for sample preparation followed by quantitation in LC-MS/MS using positive electrospray ionization technique (ESI) operating in multiple reaction monitoring (MRM) mode. Elution was achieved in gradient mode on High Resolution Chromolith RP-18e column with mobile phase comprised of acetonitrile and 0.1% (v/v) formic acid in water at the flow rate of 0.4mL/min. Precursor to product ion transitions (m/z 344.5/218.4 and m/z 237.3/194.2) were used to measure analyte and IS, respectively. All validation parameters were well within the limit of acceptance criteria. The method was successfully applied to assess the pharmacokinetics of the candidate in mice following oral (10mg/kg) and intravenous (IV; 2.5mg/kg) administration. It was also effectively used to quantitate metabolic stability of the compound in mouse liver microsomes (MLM) and human liver microsomes (HLM) followed by its in-vitro-in-vivo extrapolation. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Development of Methods of Innovative Projects’ Management in Developer Organizations

    Directory of Open Access Journals (Sweden)

    Papelniuk Oksana

    2017-01-01

    Full Text Available In article the author studies the conceptual scheme of life cycle of innovative developer project and offers methods of innovative projects' management according to the stages of its lifecycle. The author describes algorithm of the organization of management system of innovative projects in the developer organization representing set of stages and methods. The offered algorithm allows developer organizations achieve one of the main of their objectives, which is the creation of a special environment of comfortable accommodation with the emphasis on ecological compatibility and energy efficiency.

  11. Active Subspace Methods for Data-Intensive Inverse Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qiqi [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2017-04-27

    The project has developed theory and computational tools to exploit active subspaces to reduce the dimension in statistical calibration problems. This dimension reduction enables MCMC methods to calibrate otherwise intractable models. The same theoretical and computational tools can also reduce the measurement dimension for calibration problems that use large stores of data.

  12. Development of advanced MCR task analysis methods

    International Nuclear Information System (INIS)

    Na, J. C.; Park, J. H.; Lee, S. K.; Kim, J. K.; Kim, E. S.; Cho, S. B.; Kang, J. S.

    2008-07-01

    This report describes task analysis methodology for advanced HSI designs. Task analyses was performed by using procedure-based hierarchical task analysis and task decomposition methods. The results from the task analysis were recorded in a database. Using the TA results, we developed static prototype of advanced HSI and human factors engineering verification and validation methods for an evaluation of the prototype. In addition to the procedure-based task analysis methods, workload estimation based on the analysis of task performance time and analyses for the design of information structure and interaction structures will be necessary

  13. Banking Activity for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Ion Stancu

    2006-08-01

    Full Text Available he corporations gain a power of influence, unthinkable years ago; they have acquired more and more rights and, in some way, govern the life of billions of peoples and of the earth in general. With every right, comes though the responsibility of the conservation and development of the environment in which the corporations act. The banking system has a major role to play in the evolution of the international framework, given its position on the economic stage. Some important banking groups realized this fact and made important steps in the area. The case study of the Holland banking group ABN AMRO proves the complexity of the introduction of sustainable development in the core of the financial business. The implementation is neither easy nor cheap. It implies essential changes in the bank management, in the way to determine the financial policies, in how to choose the clients, the employees, the suppliers etc. Led in an efficient way, sustainable banking implies innovation, creativity and, implicitly, new gains, through creating new products and opening new markets. The international banking community proved, through leading examples (ABN AMRO Bank, HSBC Group, Rabobank Group, JP Morgan Chase, Citigroup etc. that it understands the importance, the necessity and also the viability of the sustainable development.

  14. Developing a TQM quality management method model

    NARCIS (Netherlands)

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This

  15. Usability Evaluation Method for Agile Software Development

    Directory of Open Access Journals (Sweden)

    Saad Masood Butt

    2015-02-01

    Full Text Available Agile methods are the best fit for tremendously growing software industry due to its flexible and dynamic nature. But the software developed using agile methods do meet the usability standards? To answer this question we can see that majority of agile software development projects currently involve interactive user interface designs, which can only be possible by following User Centered Design (UCD in agile methods. The question here is, how to integrate UCD with agile models. Both Agile models and UCD are iterative in nature but agile models focus on coding and development of software; whereas, UCD focuses on user interface of the software. Similarly, both of them have testing features where the agile model involves automated tested code while UCD involves an expert or a user to test the user interface. In this paper, a new agile usability model is proposed and the evaluation is of the proposed model is presented by practically implementing it in three real life projects. . Key results from these projects clearly show: the proposed agile model incorporates usability evaluation methods, improves the relationship between usability experts to work with agile software experts; in addition, allows agile developers to incorporate the result from UCD into subsequent interactions.

  16. A Framework for Teaching Software Development Methods

    Science.gov (United States)

    Dubinsky, Yael; Hazzan, Orit

    2005-01-01

    This article presents a study that aims at constructing a teaching framework for software development methods in higher education. The research field is a capstone project-based course, offered by the Technion's Department of Computer Science, in which Extreme Programming is introduced. The research paradigm is an Action Research that involves…

  17. Automating Object-Oriented Software Development Methods

    NARCIS (Netherlands)

    Tekinerdogan, B.; Saeki, Motoshi; Sunyé, Gerson; van den Broek, P.M.; Hruby, Pavel; Tekinerdogan, B.; van den Broek, P.M.; Saeki, M.; Hruby, P.; Sunye, G.

    2001-01-01

    Current software projects have generally to deal with producing and managing large and complex software products. It is generally believed that applying software development methods are useful in coping with this complexity and for supporting quality. As such numerous object-oriented software

  18. Automating Object-Oriented Software Development Methods

    NARCIS (Netherlands)

    Tekinerdogan, B.; Frohner, A´ kos; Saeki, Motoshi; Sunyé, Gerson; van den Broek, P.M.; Hruby, Pavel

    2002-01-01

    Current software projects have generally to deal with producing and managing large and complex software products. It is generally believed that applying software development methods are useful in coping with this complexity and for supporting quality. As such numerous object-oriented software

  19. Activation method for measuring the neutron spectra parameters. Computer software

    International Nuclear Information System (INIS)

    Efimov, B.V.; Ionov, V.S.; Konyaev, S.I.; Marin, S.V.

    2005-01-01

    The description of mathematical statement of a task for definition the spectral characteristics of neutron fields with use developed in RRC KI unified activation detectors (UKD) is resulted. The method of processing of results offered by authors activation measurements and calculation of the parameters used for an estimation of the neutron spectra characteristics is discussed. Features of processing of the experimental data received at measurements of activation with using UKD are considered. Activation detectors UKD contain a little bit specially the picked up isotopes giving at irradiation peaks scale of activity in the common spectrum scale of activity. Computing processing of results of the measurements is applied on definition of spectrum parameters for nuclear reactor installations with thermal and close to such power spectrum of neutrons. The example of the data processing, the measurements received at carrying out at RRC KI research reactor F-1 is resulted [ru

  20. Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system.

    Science.gov (United States)

    Fujita, Akiko; Sato, Chihiro; Münster-Kühnel, Anja-K; Gerardy-Schahn, Rita; Kitajima, Ken

    2005-02-01

    A new reliable method to assay the activity of cytidine monophosphate sialic acid (CMP-Sia) synthetase (CSS) has been developed. The activation of sialic acids (Sia) to CMP-Sia is a prerequisite for the de novo synthesis of sialoglycoconjugates. In vertebrates, CSS has been cloned from human, mouse, and rainbow trout, and the crystal structure has been resolved for the mouse enzyme. The mouse and rainbow trout enzyme have been compared with respect to substrate specificity, demonstrating that the mouse enzyme exhibits a pronounced specificity for N-acetylneuraminic acid (Neu5Ac), while the rainbow trout CSS is equally active with either of three Sia species, Neu5Ac, N-glycolylneuraminic acid (Neu5Gc), and deaminoneuraminic acid (KDN). However, molecular details that explain the pronounced substrate specificities are unknown. Understanding the catalytic mechanisms of these enzymes is of major importance, since CSSs play crucial roles in cellular sialylation patterns and thus are potential drug targets in a number of pathophysiological situations. The availability of the cDNAs and the obtained structural data enable rational approaches; however, these efforts are limited by the lack of a reliable high-throughput assay system. Here we describe a new assay system that allows product quantification in a reduced nicotinamide adenine dinucleotide (NADH)-dependent color reaction. The activation reaction catalyzed by CSS, CTP+Sia-->CMP-Sia+pyrophosphate, was evaluated by a consumption of Sia, which corresponds to that of NADH on the following two successive reactions: (i) Sia-->pyruvate+ManNAc (or Man), catalyzed by a sialic acid lyase (SAL), and (ii) pyruvate+NADH-->lactate+oxidized nicotinamide adenine dinucleotide (NAD+), catalyzed by a lactate dehydrogenase (LDH). Consumption of NADH can be photometrically monitored on a microtiter plate reader for a number of test samples at the same time. Furthermore, based on the quantification of CSS used in the SAL/LDH assay

  1. A bootstrapping method for development of Treebank

    Science.gov (United States)

    Zarei, F.; Basirat, A.; Faili, H.; Mirain, M.

    2017-01-01

    Using statistical approaches beside the traditional methods of natural language processing could significantly improve both the quality and performance of several natural language processing (NLP) tasks. The effective usage of these approaches is subject to the availability of the informative, accurate and detailed corpora on which the learners are trained. This article introduces a bootstrapping method for developing annotated corpora based on a complex and rich linguistically motivated elementary structure called supertag. To this end, a hybrid method for supertagging is proposed that combines both of the generative and discriminative methods of supertagging. The method was applied on a subset of Wall Street Journal (WSJ) in order to annotate its sentences with a set of linguistically motivated elementary structures of the English XTAG grammar that is using a lexicalised tree-adjoining grammar formalism. The empirical results confirm that the bootstrapping method provides a satisfactory way for annotating the English sentences with the mentioned structures. The experiments show that the method could automatically annotate about 20% of WSJ with the accuracy of F-measure about 80% of which is particularly 12% higher than the F-measure of the XTAG Treebank automatically generated from the approach proposed by Basirat and Faili [(2013). Bridge the gap between statistical and hand-crafted grammars. Computer Speech and Language, 27, 1085-1104].

  2. Stochastic development regression using method of moments

    DEFF Research Database (Denmark)

    Kühnel, Line; Sommer, Stefan Horst

    2017-01-01

    This paper considers the estimation problem arising when inferring parameters in the stochastic development regression model for manifold valued non-linear data. Stochastic development regression captures the relation between manifold-valued response and Euclidean covariate variables using...... the stochastic development construction. It is thereby able to incorporate several covariate variables and random effects. The model is intrinsically defined using the connection of the manifold, and the use of stochastic development avoids linearizing the geometry. We propose to infer parameters using...... the Method of Moments procedure that matches known constraints on moments of the observations conditional on the latent variables. The performance of the model is investigated in a simulation example using data on finite dimensional landmark manifolds....

  3. Scientific methods for developing ultrastable structures

    International Nuclear Information System (INIS)

    Gamble, M.; Thompson, T.; Miller, W.

    1990-01-01

    Scientific methods used by the Los Alamos National Laboratory for developing an ultrastable structure for study of silicon-based elementary particle tracking systems are addressed. In particular, the design, analysis, and monitoring of this system are explored. The development methodology was based on a triad of analytical, computational, and experimental techniques. These were used to achieve a significant degree of mechanical stability (alignment accuracy >1 μrad) and yet allow dynamic manipulation of the system. Estimates of system thermal and vibratory stability and component performance are compared with experimental data collected using laser interferometry and accelerometers. 8 refs., 5 figs., 4 tabs

  4. Development of a transient criticality evaluation method

    International Nuclear Information System (INIS)

    Pain, C.C.; Eaton, M.D.; Miles, B.; Ziver, A.K.; Gomes, J.L.M.A.; Umpleby, A.P.; Piggott, M.D.; Goddard, A.J.H.; Oliveira, C.R.E. de

    2005-01-01

    In developing a transient criticality evaluation method we model, in full spatial/temporal detail, the neutron fluxes and consequent power and the evolving material properties - their flows, energies, phase changes etc. These methods are embodied in the generic method FETCH code which is based as far as possible on basic principles and is capable of use in exploring safety-related situations somewhat beyond the range of experiment. FETCH is a general geometry code capable of addressing a range of criticality issues in fissile materials. The code embodies both transient radiation transport and transient fluid dynamics. Work on powders, granular materials, porous media and solutions is reviewed. The capability for modelling transient criticality for chemical plant, waste matrices and advanced reactors is also outlined. (author)

  5. Development of Quantification Method for Bioluminescence Imaging

    International Nuclear Information System (INIS)

    Kim, Hyeon Sik; Min, Jung Joon; Lee, Byeong Il; Choi, Eun Seo; Tak, Yoon O; Choi, Heung Kook; Lee, Ju Young

    2009-01-01

    Optical molecular luminescence imaging is widely used for detection and imaging of bio-photons emitted by luminescent luciferase activation. The measured photons in this method provide the degree of molecular alteration or cell numbers with the advantage of high signal-to-noise ratio. To extract useful information from the measured results, the analysis based on a proper quantification method is necessary. In this research, we propose a quantification method presenting linear response of measured light signal to measurement time. We detected the luminescence signal by using lab-made optical imaging equipment of animal light imaging system (ALIS) and different two kinds of light sources. One is three bacterial light-emitting sources containing different number of bacteria. The other is three different non-bacterial light sources emitting very weak light. By using the concept of the candela and the flux, we could derive simplified linear quantification formula. After experimentally measuring light intensity, the data was processed with the proposed quantification function. We could obtain linear response of photon counts to measurement time by applying the pre-determined quantification function. The ratio of the re-calculated photon counts and measurement time present a constant value although different light source was applied. The quantification function for linear response could be applicable to the standard quantification process. The proposed method could be used for the exact quantitative analysis in various light imaging equipment with presenting linear response behavior of constant light emitting sources to measurement time

  6. Development and validation of a simple high performance thin layer chromatography method combined with direct 1,1-diphenyl-2-picrylhydrazyl assay to quantify free radical scavenging activity in wine.

    Science.gov (United States)

    Agatonovic-Kustrin, Snezana; Morton, David W; Yusof, Ahmad P

    2016-04-15

    The aim of this study was to: (a) develop a simple, high performance thin layer chromatographic (HPTLC) method combined with direct 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay to rapidly assess and compare free radical scavenging activity or anti-oxidant activity for major classes of polyphenolics present in wines; and (b) to investigate relationship between free radical scavenging activity to the total polyphenolic content (TPC) and total antioxidant capacity (TAC) in the wine samples. The most potent free radical scavengers that we tested for in the wine samples were found to be resveratrol (polyphenolic non-flavonoid) and rutin (flavonoid), while polyphenolic acids (caffeic acid and gallic acid) although present in all wine samples were found to be less potent free radical scavengers. Therefore, the total antioxidant capacity was mostly affected by the presence of resveratrol and rutin, while total polyphenolic content was mostly influenced by the presence of the less potent free radical scavengers gallic and caffeic acids. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Using of the surface activation method for enhancement of machine realibility

    International Nuclear Information System (INIS)

    Postnikov, V.I.; Garbar, I.N.

    1979-01-01

    A surface activation method is described for controlling the wear of units and details, allowing one to measure the wear at continuous operation of the mechanism by any program. The main advantages of the surface activation method for the wear tests are shown. By means of that method it was possible to develop a simultaneous controlling conjugate detail wear, and a method of different-activity brands, as well as the method for repeated activation of details. Development of theory for the engineering and technology of engine wear control by the surface activation method allowed one to improve the efficiency and reduce the time of research in the field of friction and wear

  8. Prioritizing pesticide compounds for analytical methods development

    Science.gov (United States)

    Norman, Julia E.; Kuivila, Kathryn; Nowell, Lisa H.

    2012-01-01

    The U.S. Geological Survey (USGS) has a periodic need to re-evaluate pesticide compounds in terms of priorities for inclusion in monitoring and studies and, thus, must also assess the current analytical capabilities for pesticide detection. To meet this need, a strategy has been developed to prioritize pesticides and degradates for analytical methods development. Screening procedures were developed to separately prioritize pesticide compounds in water and sediment. The procedures evaluate pesticide compounds in existing USGS analytical methods for water and sediment and compounds for which recent agricultural-use information was available. Measured occurrence (detection frequency and concentrations) in water and sediment, predicted concentrations in water and predicted likelihood of occurrence in sediment, potential toxicity to aquatic life or humans, and priorities of other agencies or organizations, regulatory or otherwise, were considered. Several existing strategies for prioritizing chemicals for various purposes were reviewed, including those that identify and prioritize persistent, bioaccumulative, and toxic compounds, and those that determine candidates for future regulation of drinking-water contaminants. The systematic procedures developed and used in this study rely on concepts common to many previously established strategies. The evaluation of pesticide compounds resulted in the classification of compounds into three groups: Tier 1 for high priority compounds, Tier 2 for moderate priority compounds, and Tier 3 for low priority compounds. For water, a total of 247 pesticide compounds were classified as Tier 1 and, thus, are high priority for inclusion in analytical methods for monitoring and studies. Of these, about three-quarters are included in some USGS analytical method; however, many of these compounds are included on research methods that are expensive and for which there are few data on environmental samples. The remaining quarter of Tier 1

  9. Structural reliability methods: Code development status

    Science.gov (United States)

    Millwater, Harry R.; Thacker, Ben H.; Wu, Y.-T.; Cruse, T. A.

    1991-05-01

    The Probabilistic Structures Analysis Method (PSAM) program integrates state of the art probabilistic algorithms with structural analysis methods in order to quantify the behavior of Space Shuttle Main Engine structures subject to uncertain loadings, boundary conditions, material parameters, and geometric conditions. An advanced, efficient probabilistic structural analysis software program, NESSUS (Numerical Evaluation of Stochastic Structures Under Stress) was developed as a deliverable. NESSUS contains a number of integrated software components to perform probabilistic analysis of complex structures. A nonlinear finite element module NESSUS/FEM is used to model the structure and obtain structural sensitivities. Some of the capabilities of NESSUS/FEM are shown. A Fast Probability Integration module NESSUS/FPI estimates the probability given the structural sensitivities. A driver module, PFEM, couples the FEM and FPI. NESSUS, version 5.0, addresses component reliability, resistance, and risk.

  10. Developments of an Interactive Sail Design Method

    OpenAIRE

    S. M. Malpede; M. Vezza

    2000-01-01

    This paper presents a new tool for performing the integrated design and analysis of a sail. The features of the system are the geometrical definition of a sail shape, using the Bezier surface method, the creation of a finite element model for the non-linear structural analysis and a fluid-dynamic model for the aerodynamic analysis. The system has been developed using MATLAB(r). Recent sail design efforts have been focused on solving the aeroelastic behavior of the sail. The pressure dis...

  11. The Methodical Approaches to Activation of Innovative Potential of Enterprise

    Directory of Open Access Journals (Sweden)

    Berveno Oksana V.

    2017-12-01

    Full Text Available The article is aimed at developing theoretical provisions and practical recommendations on methods of management and activation of innovative potential of enterprises. Assessment of innovative potential of enterprise should be carried out from different positions, taking into consideration all external and internal possibilities of enterprise as to carrying out an innovation activity. The system of management of innovation activity and implementation of innovative potential at enterprise should be closely woven in the general management of the enterprise. Activation of innovative potential of enterprise foresees adoption of the whole system of strategic decisions, which are aimed at creation of the most favorable conditions for implementation of innovative potential with obtaining of planned results. The system of activization of innovative potential should develop a number of organizational decisions on interaction of elements of the most innovative potential in the process of innovation activity and cooperation of innovative potential with other subsystems of the enterprise. Results of these organizational decisions in many respects determine efficiency of innovation activity of the enterprise.

  12. Development of SERS active fibre sensors

    International Nuclear Information System (INIS)

    Polwart, Ewan

    2002-01-01

    Surface-enhanced Raman scattering (SERS) is sensitive and selective and when coupled with fibre-optics could potentially produce an effective chemical sensing system. This thesis concerns the development of a single-fibre-based sensor, with an integral SERS-active substrate. A number of different methods for the manufacture of SERS-active surfaces on glass substrates were investigated and compared. The immobilisation of metal nanoparticles on glass functionalised with (3-aminopropyl)trimethoxysilane emerged as a suitable approach for the production of sensors. Substrates prepared by this approach were characterised using UV-visible spectroscopy, electron microscopy and Raman mapping. It was found that exposure of substrates to laser radiation led to a decrease in the signal recorded from adsorbed analytes. This speed of the decrease was shown to depend on the analyte, and the exciting wavelength and power. SERS-active fibre sensors were produced by immobilisation of silver nanoparticles at the distal end of a (3-aminopropyl)trimethoxysilane-derivatised optical fibre. These sensors were used to obtain spectra with good signal to noise ratios from 4-(benzotriazol-5-ylazo)-3,5-dimethoxyphenylamine and crystal violet. Sensing of dyes in effluent was also investigated. The development of sensors for the measurement of pH, by treating the SERS-active fibre tip with pH sensitive dyes is also described. Spectral changes were observed with these sensors as a response to the pH. Partial least squares regression was used to produce linear calibration models for the pH range 5-11 from which it was possible to predict the pH with an accuracy of ∼0.2 pH units. Some of the limitations of these sensors were explored. The feasibility of using these sensors for measurement of oxygen and thiols, was investigated. The measurement of oxygen using methylene blue as a transducer was demonstrated. Two transduction methodologies--reactions with iron porphyrins and pyrrole-2,5-diones

  13. Development of numerical methods for reactive transport

    International Nuclear Information System (INIS)

    Bouillard, N.

    2006-12-01

    When a radioactive waste is stored in deep geological disposals, it is expected that the waste package will be damaged under water action (concrete leaching, iron corrosion). Then, to understand these damaging processes, chemical reactions and solutes transport are modelled. Numerical simulations of reactive transport can be done sequentially by the coupling of several codes. This is the case of the software platform ALLIANCES which is developed jointly with CEA, ANDRA and EDF. Stiff reactions like precipitation-dissolution are crucial for the radioactive waste storage applications, but standard sequential iterative approaches like Picard's fail in solving rapidly reactive transport simulations with such stiff reactions. In the first part of this work, we focus on a simplified precipitation and dissolution process: a system made up with one solid species and two aqueous species moving by diffusion is studied mathematically. It is assumed that a precipitation dissolution reaction occurs in between them, and it is modelled by a discontinuous kinetics law of unknown sign. By using monotonicity properties, the convergence of a finite volume scheme on admissible mesh is proved. Existence of a weak solution is obtained as a by-product of the convergence of the scheme. The second part is dedicated to coupling algorithms which improve Picard's method and can be easily used in an existing coupling code. By extending previous works, we propose a general and adaptable framework to solve nonlinear systems. Indeed by selecting special options, we can either recover well known methods, like nonlinear conjugate gradient methods, or design specific method. This algorithm has two main steps, a preconditioning one and an acceleration one. This algorithm is tested on several examples, some of them being rather academical and others being more realistic. We test it on the 'three species model'' example. Other reactive transport simulations use an external chemical code CHESS. For a

  14. Antioxidant activity of wine assessed by different in vitro methods

    Directory of Open Access Journals (Sweden)

    Di Lorenzo Chiara

    2017-01-01

    Full Text Available Epidemiological studies have suggested that a diet rich in antioxidant compounds could help in counteracting the effects of reactive oxygen species, reducing the risk factors for chronic diseases. The moderate consumption of wine, especially red wine, has been associated with the reduction in mortalities from cardiovascular diseases. One of the possible reasons for the protective effect of wine can be identified in the high content of polyphenols (mainly flavonoids, which have significant antioxidant activity. Even though several in vitro tests have been developed for the measure of the antioxidant property, no method has showed a satisfactory correlation with the in vivo situation. On these bases, the aim of this study was the application and comparison of different in vitro methods to assess the antioxidant activity of red, rosé and white wines. The methods were: 1 Folin-Cocalteau's assay for the quantification of total polyphenol content; 2 the DPPH (1,1-diphenyl-2-picrylhydrazyl spectrophotometric assay and the Trolox Equivalent Antioxidant Capacity (TEAC spectrophotometric assay for measuring the antioxidant activity of samples; 3 High Performance Thin Layer Chromatography for separation of phenolic substances and assessment of the associated antioxidant activity; 4 electrochemical detection by using a biosensor. Although all the approaches show some limitations, this battery of tests offers a more reliable body of data on the antioxidant activity of vine derivatives.

  15. Participation in development activities: attitudinal and social ...

    African Journals Online (AJOL)

    What psychological factors determine Ghanaian employee participation in development activities in organizations? Empirical research has failed to examine psychological factors influencing employee behavior in Ghanaian organizations. Using the Theory of Reasoned Action (Ajzen & Fishbein, 1980), I examine attitudinal ...

  16. Development of methods for the neutron activation analysis to the determination of essential and toxic trace elements of biological and environmental samples: application of enzyme activity of raw hides

    International Nuclear Information System (INIS)

    Sipos, T.; Nagy, L.G.; Toeroek, G.; Kollar, J.

    1974-01-01

    Investigations on the post mortem enzymatic processes pointed out the fact, that significant deviations can be observed in the extent and in the results of the autolytic transformations occurring during the storage of raw hide. A neutron activation analysis procedure, based on a semiautomated radiochemical separation procedure and scintillation gamma spectrometry, was selected for the determination of some trace elements. Six trace elements, Cu, Mn, Zn, Au, As, and Cr, and one minor component,Br, were detected and/or determined in the concentration region of 0,1-10 3 ppM. According to preliminary investigations evaluated at the time being, concentration differences of some orders of magnitude were obtained for some trace elements: copper, zinc and manganese, whereas the concentration of bromine remained practically constant. These findings seem to correlate with large differences in appearance due to different enzyme activities in the raw hides

  17. Manufacturing development of low activation vanadium alloys

    International Nuclear Information System (INIS)

    Smith, J.P.; Johnson, W.R.; Baxi, C.B.

    1996-10-01

    General Atomics is developing manufacturing methods for vanadium alloys as part of a program to encourage the development of low activation alloys for fusion use. The culmination of the program is the fabrication and installation of a vanadium alloy structure in the DIII-D tokamak as part of the Radiative Divertor modification. Water-cooled vanadium alloy components will comprise a portion of the new upper divertor structure. The first step, procuring the material for this program has been completed. The largest heat of vanadium alloy made to date, 1200 kg of V-4Cr-4Ti, has been produced and is being converted into various product forms. Results of many tests on the material during the manufacturing process are reported. Research into potential fabrication methods has been and continues to be performed along with the assessment of manufacturing processes particularly in the area of joining. Joining of vanadium alloys has been identified as the most critical fabrication issue for their use in the Radiative Divertor Program. Joining processes under evaluation include resistance seam, electrodischarge (stud), friction and electron beam welding. Results of welding tests are reported. Metallography and mechanical tests are used to evaluate the weld samples. The need for a protective atmosphere during different welding processes is also being determined. General Atomics has also designed, manufactured, and will be testing a helium-cooled, high heat flux component to assess the use of helium cooled vanadium alloy components for advanced tokamak systems. The component is made from vanadium alloy tubing, machined to enhance the heat transfer characteristics, and joined to end flanges to allow connection to the helium supply. Results are reported

  18. Recent activities in accelerator code development

    International Nuclear Information System (INIS)

    Copper, R.K.; Ryne, R.D.

    1992-01-01

    In this paper we will review recent activities in the area of code development as it affects the accelerator community. We will first discuss the changing computing environment. We will review how the computing environment has changed in the last 10 years, with emphasis on computing power, operating systems, computer languages, graphics standards, and massively parallel processing. Then we will discuss recent code development activities in the areas of electromagnetics codes and beam dynamics codes

  19. Development of student self-study activities

    DEFF Research Database (Denmark)

    Kvols, Anja Madsen; Kim, Won-Chung; Christensen, Dorthe Ansine

    2015-01-01

    of the teacher education and will aim at strengthening students' motivation for choosing self-initiated activities. The motivation should for example be based on students´ perception of relevance and quality of their own initiatives and the possibility of guidance in self-selected activities. This paper...... the possibility of developing educational theories for the teachers’ education in an effort to develop independence as a study skill. Keywords: studieaktivitetsmodellen, selvstændige studieaktiviteter, kortlægning af studieaktiviteter...

  20. Development of planar detectors with active edge

    International Nuclear Information System (INIS)

    Povoli, M.; Bagolini, A.; Boscardin, M.; Dalla Betta, G.-F.; Giacomini, G.; Vianello, E.; Zorzi, N.

    2011-01-01

    We report on the first batch of planar active edge sensors fabricated at Fondazione Bruno Kessler (Trento, Italy) on the way to the development of full 3D detectors with active edges. The main design and technological aspects are reported, along with selected results from the electrical characterization of detectors and test structures.

  1. Development of planar detectors with active edge

    Energy Technology Data Exchange (ETDEWEB)

    Povoli, M., E-mail: povoli@disi.unitn.it [Dipartimento di Ingegneria e Scienza dell' Informazione, Universita di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento) (Italy); Bagolini, A.; Boscardin, M. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy); Dalla Betta, G.-F. [Dipartimento di Ingegneria e Scienza dell' Informazione, Universita di Trento, Via Sommarive, 14, I-38123 Povo di Trento (Italy); INFN, Sezione di Padova (Gruppo Collegato di Trento) (Italy); Giacomini, G.; Vianello, E.; Zorzi, N. [Fondazione Bruno Kessler, Centro per i Materiali e i Microsistemi (FBK-CMM), Via Sommarive, 18, I-38123 Povo di Trento (Italy)

    2011-12-01

    We report on the first batch of planar active edge sensors fabricated at Fondazione Bruno Kessler (Trento, Italy) on the way to the development of full 3D detectors with active edges. The main design and technological aspects are reported, along with selected results from the electrical characterization of detectors and test structures.

  2. Development and analysis of finite volume methods

    International Nuclear Information System (INIS)

    Omnes, P.

    2010-05-01

    This document is a synthesis of a set of works concerning the development and the analysis of finite volume methods used for the numerical approximation of partial differential equations (PDEs) stemming from physics. In the first part, the document deals with co-localized Godunov type schemes for the Maxwell and wave equations, with a study on the loss of precision of this scheme at low Mach number. In the second part, discrete differential operators are built on fairly general, in particular very distorted or nonconforming, bidimensional meshes. These operators are used to approach the solutions of PDEs modelling diffusion, electro and magneto-statics and electromagnetism by the discrete duality finite volume method (DDFV) on staggered meshes. The third part presents the numerical analysis and some a priori as well as a posteriori error estimations for the discretization of the Laplace equation by the DDFV scheme. The last part is devoted to the order of convergence in the L2 norm of the finite volume approximation of the solution of the Laplace equation in one dimension and on meshes with orthogonality properties in two dimensions. Necessary and sufficient conditions, relatively to the mesh geometry and to the regularity of the data, are provided that ensure the second-order convergence of the method. (author)

  3. Method development for trace and ultratrace analysis

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Method development, that is, selection of a mode of chromatography and the right column and mobile-phase combination for trace and ultratrace analysis, requires several main considerations. The method should be useful for resolving various trace and ultratrace components present in the sample. If the nature of these components is known, the choice of method may be straightforward, that is, a selection can be made from the following modes of HPLC: (1) adsorption chromatography; (2) normal-phase chromatography; (3) reversed-phase chromatography; (4) ion-pair chromatography; (5) ion-exchange chromatography; (6) ion chromatography. Unfortunately, the nature of all of the components is frequently unknown. However, several intelligent judgments can be made on the nature of impurities. This chapter deals with some basic approaches to mobile-phase selection and optimization. More detailed information may be found in basic texts. Techniques for separation of high-molecular-weight compounds (macromolecules) and chiral compounds may be found elsewhere. Mainly compounds with molecular weight lower than 2,000 are discussed here. 123 refs

  4. Method of developing thick sloping coal formations

    Energy Technology Data Exchange (ETDEWEB)

    Bragintsev, V F; Mashkovtsev, I L; Semenov, V S; Zykov, V N

    1980-02-15

    A method of developing thick sloping coal formations in three inclined layers includes carrying out developmental operations for each of the layers until one begins development of the last one and extraction of layers. It is characterized in that in order to improve efficiency and safety of an operation of formation development there is first extraction of the upper layer and then slits in sequence from the roof of the formation to the floor of the upper layer and beneath protected objects. Then the lower layer is workedin thin strips in sequence from the floor of the formation to the roof of the lower layer. Next there is extraction of a slit at the roof of the middle layer and delivery of a plasticized hardening mixture into the worked out space of the indicated slot. The middle layer is worked in thin layers beneath the protection of the formed artificial roof in a sequence from the artificial roof to the floor of the middle layer. Workings of the middle layer are formed by joining of the combined workings of the upper and lower layers during extraction of pillars of coal between them. The layers are respectively worked following completion of roof advance in front of the working face of each subsequent extraction layer in alternating fashion.

  5. Development of a practical costing method for hospitals.

    Science.gov (United States)

    Cao, Pengyu; Toyabe, Shin-Ichi; Akazawa, Kouhei

    2006-03-01

    To realize an effective cost control, a practical and accurate cost accounting system is indispensable in hospitals. In traditional cost accounting systems, the volume-based costing (VBC) is the most popular cost accounting method. In this method, the indirect costs are allocated to each cost object (services or units of a hospital) using a single indicator named a cost driver (e.g., Labor hours, revenues or the number of patients). However, this method often results in rough and inaccurate results. The activity based costing (ABC) method introduced in the mid 1990s can prove more accurate results. With the ABC method, all events or transactions that cause costs are recognized as "activities", and a specific cost driver is prepared for each activity. Finally, the costs of activities are allocated to cost objects by the corresponding cost driver. However, it is much more complex and costly than other traditional cost accounting methods because the data collection for cost drivers is not always easy. In this study, we developed a simplified ABC (S-ABC) costing method to reduce the workload of ABC costing by reducing the number of cost drivers used in the ABC method. Using the S-ABC method, we estimated the cost of the laboratory tests, and as a result, similarly accurate results were obtained with the ABC method (largest difference was 2.64%). Simultaneously, this new method reduces the seven cost drivers used in the ABC method to four. Moreover, we performed an evaluation using other sample data from physiological laboratory department to certify the effectiveness of this new method. In conclusion, the S-ABC method provides two advantages in comparison to the VBC and ABC methods: (1) it can obtain accurate results, and (2) it is simpler to perform. Once we reduce the number of cost drivers by applying the proposed S-ABC method to the data for the ABC method, we can easily perform the cost accounting using few cost drivers after the second round of costing.

  6. EDF Group: activity and sustainable development 2010

    International Nuclear Information System (INIS)

    2010-01-01

    After a map illustrating the worldwide dimension of EDF, and an interview of the EDF's chairman, this report presents and comments some sustainable development indicators for EDF activity in 2010. Then, after a presentation of the world energy context, it presents and comments EDF's main activities: energy production and engineering, network management, trading. It presents and comments the operational performance of the company in different countries (France, United Kingdom, Italy, and other countries) and evokes additional activities. The next chapter deals with human resources and with innovation and R and D activities. The last chapter presents governance structures and financial results

  7. Method for enhancing amidohydrolase activity of fatty acid amide hydrolase

    Science.gov (United States)

    John, George; Nagarajan, Subbiah; Chapman, Kent; Faure, Lionel; Koulen, Peter

    2016-10-25

    A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacylethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings. The subject matter disclosed herein relates to enhancers of amidohydrolase activity.

  8. XRSW method, its application and development

    Energy Technology Data Exchange (ETDEWEB)

    Zheludeva, S I; Kovalchuk, M V [Russian Academy of Sciences, Institute of Crystallography, Moscow (Russian Federation)

    1996-09-01

    X-Ray Standing Waves (XRSW) may be obtained under dynamical diffraction in periodic structures or under total external reflection conditions (TR) is stratified medium. As the incident angle varies, XRSW nodes and antinodes move in the direction perpendicular to the reflecting planes, leading to drastic variation of photoelectron interaction of X-ray with matter and resulting in specific angular dependencies of secondary radiation yields (photoelectrons, fluorescence, internal photoeffect, photoluminescence, Compton and thermal diffuse scattering). The structural information - the position of investigated atoms in the direction of XRSW movement (coherent position), the distribution of atoms about this position (coherent fraction) - is obtained with the accuracy about several percents from XRSW period D. The objects under investigation are: semiconductor surface layers, heterostructure, multicomponent crystals, interfaces, adsorbed layers. Besides the development of XRSW method allow to obtain structure, geometrical and optical parameters of ultrathin films (crystalline and disordered, organic and inorganic) and nanostructures on their base.

  9. Co-ordinating Product Developing Activities

    DEFF Research Database (Denmark)

    Terkelsen, Søren Bendix

    1996-01-01

    The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature......The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature...

  10. Development of a Radial Deconsolidation Method

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Montgomery, Fred C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-12-01

    A series of experiments have been initiated to determine the retention or mobility of fission products* in AGR fuel compacts [Petti, et al. 2010]. This information is needed to refine fission product transport models. The AGR-3/4 irradiation test involved half-inch-long compacts that each contained twenty designed-to-fail (DTF) particles, with 20-μm thick carbon-coated kernels whose coatings were deliberately fabricated such that they would crack under irradiation, providing a known source of post-irradiation isotopes. The DTF particles in these compacts were axially distributed along the compact centerline so that the diffusion of fission products released from the DTF kernels would be radially symmetric [Hunn, et al. 2012; Hunn et al. 2011; Kercher, et al. 2011; Hunn, et al. 2007]. Compacts containing DTF particles were irradiated at Idaho National Laboratory (INL) at the Advanced Test Reactor (ATR) [Collin, 2015]. Analysis of the diffusion of these various post-irradiation isotopes through the compact requires a method to radially deconsolidate the compacts so that nested-annular volumes may be analyzed for post-irradiation isotope inventory in the compact matrix, TRISO outer pyrolytic carbon (OPyC), and DTF kernels. An effective radial deconsolidation method and apparatus appropriate to this application has been developed and parametrically characterized.

  11. METHODIC OF DEVELOPMENT OF MOTOR GIFTEDNESS OF PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Светлана Юрьевна Федорова

    2013-05-01

    Full Text Available Education and training of gifted children today appropriate to consider as an important strategic task of modern society. In this context, the purpose of research is the development motor giftedness, which is particularly relevant at the stage of pre-school education, which is caused by age-preschoolers. Preschoolers' motor giftedness is considered by the author as developing integrated quality, including psychomotor skills, inclinations, increased motivation for motor activity. In the process of study the following methods are used:  the study and analysis of the scientific and methodological literature on studies, questioning, interview, testing of physical fitness, statistical data processing.The result of research work is methodic of development of motor giftedness on physical education in preschool. The author's methodic consists of four steps:  diagnostic, prognostic, practice and activity, social and pedagogical. Each step determines the inclusion of preschool children in sports and developing environment that meets his or her abilities and needs through the creation of certain social and educational conditions.The area of using results of the author's methodic is preschool and the system of improvement professional skill of teachers. DOI: http://dx.doi.org/10.12731/2218-7405-2013-4-31

  12. METHODIC OF DEVELOPMENT OF MOTOR GIFTEDNESS OF PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Fedorova Svetlana Yurievna

    2013-04-01

    Full Text Available Education and training of gifted children today appropriate to consider as an important strategic task of modern society. In this context, the purpose of research is the development motor giftedness, which is particularly relevant at the stage of pre-school education, which is caused by age-preschoolers. Preschoolers' motor giftedness is considered by the author as developing integrated quality, including psychomotor skills, inclinations, increased motivation for motor activity. In the process of study the following methods are used: the study and analysis of the scientific and methodological literature on studies, questioning, interview, testing of physical fitness, statistical data processing. The result of research work is methodic of development of motor giftedness on physical education in preschool. The author's methodic consists of four steps: diagnostic, prognostic, practice and activity, social and pedagogical. Each step determines the inclusion of preschool children in sports and developing environment that meets his or her abilities and needs through the creation of certain social and educational conditions. The area of using results of the author's methodic is preschool and the system of improvement professional skill of teachers.

  13. The development of interdepartmental audit methods

    International Nuclear Information System (INIS)

    Thwaites, D.I.; Allahverdi, M.

    1995-01-01

    The UK Radiotherapy Physics Audit Network is now well-established, with seven network groups and co-ordinated by the IPSM. It is based on visits, using ion chambers as the measurement method, and auditing at least machine calibration, single field parameters and simple multi-field planned irradiations. In addition procedural audit of dosimetry and quality control procedures, and records is incorporated. The general approach has been to use interdepartmental audit involving mutual co-operation with peer professionals from other centres. The different groups have evolved at different paces and in rather different directions. However the IPSM coordinating role ensures a basic common minimum to the system. The Scottish+ group has developed a semi-anatomical phantom to use in audit stages following on from the basic single field and geometric phantom dosimetry audit levels. This has been evaluated experimentally in one department before wider use. The Scottish+ audit system is briefly described. Results from levels 1 and 2 are summarised and the design and testing of the semi-anatomical phantom are discussed. The current and future development of the audit system is presented

  14. Method of developing thick sloping coal formations

    Energy Technology Data Exchange (ETDEWEB)

    Bragintsev, V F; Mashkovtsev, I L; Semenov, V S; Zykov, V N

    1980-04-25

    A method is patented for developing thick sloping coal formations in 3 inclined layers. It includes conducting developmental operations for each of the layers until one begins the last one and extraction of the layers. In order to improve effectivess and extraction operation safety one first carried out preliminary development of a formation in thin strips beneath protected objects when extracting formation which contain alot of gas. Then one removes the gas of a formation through boreholes that have been drilled into the formation from the indicated workings. Then one works the upper layer in thin strips in a sequence from the roof of the formation to the floor of the upper layer. The one strengthens roof rock of the formation by pumping in a quickly hardening solution into the boreholes which have been drilled into the roof of the formation after processing the upper layer. The middle layer is worked in thin strips in the sequence from the roof to the ground of the middle layer, then the lower layer of the formation is strengthened by pumping in quickly hardening solution into the formation along degasified boreholes and it is worked in thin strips in sequence from the ground of the lower to its roof. Workings are shaped respectively for the middle and lower layers by deepening workings of the upper and middle layers. The layers are worked respectively after finishing displacement of the roof in front of the extraction face of each subsequent extraction of a layer in alternating fashion.

  15. Development of fluorescent methods for DNA methyltransferase assay

    Science.gov (United States)

    Li, Yueying; Zou, Xiaoran; Ma, Fei; Tang, Bo; Zhang, Chun-yang

    2017-03-01

    DNA methylation modified by DNA methyltransferase (MTase) plays an important role in regulating gene transcription, cell growth and proliferation. The aberrant DNA MTase activity may lead to a variety of human diseases including cancers. Therefore, accurate and sensitive detection of DNA MTase activity is crucial to biomedical research, clinical diagnostics and therapy. However, conventional DNA MTase assays often suffer from labor-intensive operations and time-consuming procedures. Alternatively, fluorescent methods have significant advantages of simplicity and high sensitivity, and have been widely applied for DNA MTase assay. In this review, we summarize the recent advances in the development of fluorescent methods for DNA MTase assay. These emerging methods include amplification-free and the amplification-assisted assays. Moreover, we discuss the challenges and future directions of this area.

  16. Developing Teaching Material Software Assisted for Numerical Methods

    Science.gov (United States)

    Handayani, A. D.; Herman, T.; Fatimah, S.

    2017-09-01

    The NCTM vision shows the importance of two things in school mathematics, which is knowing the mathematics of the 21st century and the need to continue to improve mathematics education to answer the challenges of a changing world. One of the competencies associated with the great challenges of the 21st century is the use of help and tools (including IT), such as: knowing the existence of various tools for mathematical activity. One of the significant challenges in mathematical learning is how to teach students about abstract concepts. In this case, technology in the form of mathematics learning software can be used more widely to embed the abstract concept in mathematics. In mathematics learning, the use of mathematical software can make high level math activity become easier accepted by student. Technology can strengthen student learning by delivering numerical, graphic, and symbolic content without spending the time to calculate complex computing problems manually. The purpose of this research is to design and develop teaching materials software assisted for numerical method. The process of developing the teaching material starts from the defining step, the process of designing the learning material developed based on information obtained from the step of early analysis, learners, materials, tasks that support then done the design step or design, then the last step is the development step. The development of teaching materials software assisted for numerical methods is valid in content. While validator assessment for teaching material in numerical methods is good and can be used with little revision.

  17. Developments in welding and joining methods of metallic materials

    International Nuclear Information System (INIS)

    Pilarczyk, J.

    2007-01-01

    The impact of the welding technology on the economy development. The welding and joining methods review. The particular role of the laser welding and its interesting applications: with filler metal, twin spot laser welding, hybrid welding process, remote welding. The fiber lasers. The high intensity electron beams applications for surface modification. The TIG welding with the use of the active flux. Friction welding, friction stir welding and friction linear welding. (author)

  18. A gradient activation method for direct methanol fuel cells

    International Nuclear Information System (INIS)

    Liu, Guicheng; Yang, Zhaoyi; Halim, Martin; Li, Xinyang; Wang, Manxiang; Kim, Ji Young; Mei, Qiwen; Wang, Xindong; Lee, Joong Kee

    2017-01-01

    Highlights: • A gradient activation method was reported firstly for direct methanol fuel cells. • The activity recovery of Pt-based catalyst was introduced into the novel activation process. • The new activation method led to prominent enhancement of DMFC performance. • DMFC performance was improved with the novel activation step by step within 7.5 h. - Abstract: To realize gradient activation effect and recover catalytic activity of catalyst in a short time, a gradient activation method has firstly been proposed for enhancing discharge performance and perfecting activation mechanism of the direct methanol fuel cell (DMFC). This method includes four steps, i.e. proton activation, activity recovery activation, H_2-O_2 mode activation and forced discharging activation. The results prove that the proposed method has gradually realized replenishment of water and protons, recovery of catalytic activity of catalyst, establishment of transfer channels for electrons, protons, and oxygen, and optimization of anode catalyst layer for methanol transfer in turn. Along with the novel activation process going on, the DMFC discharge performance has been improved, step by step, to more than 1.9 times higher than that of the original one within 7.5 h. This method provides a practicable activation way for the real application of single DMFCs and stacks.

  19. High activity gamma irradiators developed in Hungary

    International Nuclear Information System (INIS)

    Stenger, V.

    1997-01-01

    The development of high activity Gamma irradiators began in Hungary already in the early years of 60s. The very first designs were serving research in irradiation chemistry, radiation physics, food and agricultural research, radiation sterilization, plastic radiation chemistry, radiobiology, cancer therapy, personal and high dose dosimetry, following the international trends. Domestic and new international demands forced us to design and construct High Activity Gamma Irradiators: Multipurpose Pilot, Portable and Large scale bulk, Multipurpose Industrial scale types

  20. Methods for Rapid Screening in Woody Plant Herbicide Development

    Directory of Open Access Journals (Sweden)

    William Stanley

    2014-07-01

    Full Text Available Methods for woody plant herbicide screening were assayed with the goal of reducing resources and time required to conduct preliminary screenings for new products. Rapid screening methods tested included greenhouse seedling screening, germinal screening, and seed screening. Triclopyr and eight experimental herbicides from Dow AgroSciences (DAS 313, 402, 534, 548, 602, 729, 779, and 896 were tested on black locust, loblolly pine, red maple, sweetgum, and water oak. Screening results detected differences in herbicide and species in all experiments in much less time (days to weeks than traditional field screenings and consumed significantly less resources (<500 mg acid equivalent per herbicide per screening. Using regression analysis, various rapid screening methods were linked into a system capable of rapidly and inexpensively assessing herbicide efficacy and spectrum of activity. Implementation of such a system could streamline early-stage herbicide development leading to field trials, potentially freeing resources for use in development of beneficial new herbicide products.

  1. Development of a method for personal, spatiotemporal exposure assessment.

    Science.gov (United States)

    Adams, Colby; Riggs, Philip; Volckens, John

    2009-07-01

    This work describes the development and evaluation of a high resolution, space and time-referenced sampling method for personal exposure assessment to airborne particulate matter (PM). This method integrates continuous measures of personal PM levels with the corresponding location-activity (i.e. work/school, home, transit) of the subject. Monitoring equipment include a small, portable global positioning system (GPS) receiver, a miniature aerosol nephelometer, and an ambient temperature monitor to estimate the location, time, and magnitude of personal exposure to particulate matter air pollution. Precision and accuracy of each component, as well as the integrated method performance were tested in a combination of laboratory and field tests. Spatial data was apportioned into pre-determined location-activity categories (i.e. work/school, home, transit) with a simple, temporospatially-based algorithm. The apportioning algorithm was extremely effective with an overall accuracy of 99.6%. This method allows examination of an individual's estimated exposure through space and time, which may provide new insights into exposure-activity relationships not possible with traditional exposure assessment techniques (i.e., time-integrated, filter-based measurements). Furthermore, the method is applicable to any contaminant or stressor that can be measured on an individual with a direct-reading sensor.

  2. Gross motor development and physical activity in kindergarten age children.

    Science.gov (United States)

    Colella, Dario; Morano, Milena

    2011-10-01

    Physical activity in kindergarten is a fundamental part of the child's educational process. Body experience and physical activity contribute to the development of self-awareness and the learning of different modes of expression, as well as encouraging the acquisition of physically active lifestyles. Recent scientific evidence has confirmed the role of physical activity in disease prevention and quality of life improvement, and stressed the importance of integrated educational programmes promoting physical activity and healthy eating habits. A key priority of scientific research is to identify the opportunities and methods of motor learning and to increase the daily physical activity levels of children by reducing sedentary time and promoting active play and transport (i.e. walking, cycling). Family, school and community involvement are all needed to assure adherence to the official guidelines on how much physical activity children need to boost their health and stave off obesity.

  3. Developments of an Interactive Sail Design Method

    Directory of Open Access Journals (Sweden)

    S. M. Malpede

    2000-01-01

    Full Text Available This paper presents a new tool for performing the integrated design and analysis of a sail. The features of the system are the geometrical definition of a sail shape, using the Bezier surface method, the creation of a finite element model for the non-linear structural analysis and a fluid-dynamic model for the aerodynamic analysis. The system has been developed using MATLAB(r. Recent sail design efforts have been focused on solving the aeroelastic behavior of the sail. The pressure distribution on a sail changes continuously, by virtue of cloth stretch and flexing. The sail shape determines the pressure distribution and, at the same time, the pressure distribution on the sail stretches and flexes the sail material determining its shape. This characteristic non-linear behavior requires iterative solution strategies to obtain the equilibrium configuration and evaluate the forces involved. The aeroelastic problem is tackled by combining structural with aerodynamic analysis. Firstly, pressure loads for a known sail-shape are computed (aerodynamic analysis. Secondly, the sail-shape is analyzed for the obtained external loads (structural analysis. The final solution is obtained by using an iterative analysis process, which involves both aerodynamic and the structural analysis. When the solution converges, it is possible to make design modifications.

  4. Activity coefficients from molecular simulations using the OPAS method

    Science.gov (United States)

    Kohns, Maximilian; Horsch, Martin; Hasse, Hans

    2017-10-01

    A method for determining activity coefficients by molecular dynamics simulations is presented. It is an extension of the OPAS (osmotic pressure for the activity of the solvent) method in previous work for studying the solvent activity in electrolyte solutions. That method is extended here to study activities of all components in mixtures of molecular species. As an example, activity coefficients in liquid mixtures of water and methanol are calculated for 298.15 K and 323.15 K at 1 bar using molecular models from the literature. These dense and strongly interacting mixtures pose a significant challenge to existing methods for determining activity coefficients by molecular simulation. It is shown that the new method yields accurate results for the activity coefficients which are in agreement with results obtained with a thermodynamic integration technique. As the partial molar volumes are needed in the proposed method, the molar excess volume of the system water + methanol is also investigated.

  5. Development and validation of analytical methods for dietary supplements

    International Nuclear Information System (INIS)

    Sullivan, Darryl; Crowley, Richard

    2006-01-01

    The expanding use of innovative botanical ingredients in dietary supplements and foods has resulted in a flurry of research aimed at the development and validation of analytical methods for accurate measurement of active ingredients. The pressing need for these methods is being met through an expansive collaborative initiative involving industry, government, and analytical organizations. This effort has resulted in the validation of several important assays as well as important advances in the method engineering procedures which have improved the efficiency of the process. The initiative has also allowed researchers to hurdle many of the barricades that have hindered accurate analysis such as the lack of reference standards and comparative data. As the availability for nutraceutical products continues to increase these methods will provide consumers and regulators with the scientific information needed to assure safety and dependable labeling

  6. Method for enhancing amidohydrolase activity of fatty acid amide hydrolase

    Science.gov (United States)

    John, George; Nagarajan, Subbiah; Chapman, Kent; Faure, Lionel; Koulen, Peter

    2017-12-26

    A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.

  7. Coal and sustainable development: utilities and activity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Reflecting its continuing focus on coal and sustainable development, the CIAB surveyed its Members about their attitudes to sustainable development and to obtain information on sustainable development activities within their organisations. The survey revealed that awareness of the importance of sustainable development has increased significantly in the past three years, with a clear majority of respondents seeing it as aligning with their commercial objectives. Reducing emissions from coal use is seen as the key priority, although the importance of this relative to other priorities varies on a regional basis depending on local circumstances. While a large majority of respondents recognised the importance of sustainable development and its increasing influence on decision-making within the coal industry, there was a wide range in the extent of activities. Some organisations have embarked on broad initiatives to better align their practices to sustainable development priorities. The range of activities suggests an evolutionary process - one that commences with a sole internal focus on economic priorities for the business, and then broadens to include local environmental issues and the community. Leading organisations are now moving to look more at global issues, to recognise and share the responsibility for the social and environmental impacts of producing and using their products, and to better engage stakeholders. 4 figs.

  8. Reduction Method for Active Distribution Networks

    DEFF Research Database (Denmark)

    Raboni, Pietro; Chen, Zhe

    2013-01-01

    On-line security assessment is traditionally performed by Transmission System Operators at the transmission level, ignoring the effective response of distributed generators and small loads. On the other hand the required computation time and amount of real time data for including Distribution...... Networks also would be too large. In this paper an adaptive aggregation method for subsystems with power electronic interfaced generators and voltage dependant loads is proposed. With this tool may be relatively easier including distribution networks into security assessment. The method is validated...... by comparing the results obtained in PSCAD® with the detailed network model and with the reduced one. Moreover the control schemes of a wind turbine and a photovoltaic plant included in the detailed network model are described....

  9. Quantitative Method of Measuring Metastatic Activity

    Science.gov (United States)

    Morrison, Dennis R. (Inventor)

    1999-01-01

    The metastatic potential of tumors can be evaluated by the quantitative detection of urokinase and DNA. The cell sample selected for examination is analyzed for the presence of high levels of urokinase and abnormal DNA using analytical flow cytometry and digital image analysis. Other factors such as membrane associated uroldnase, increased DNA synthesis rates and certain receptors can be used in the method for detection of potentially invasive tumors.

  10. Tensor analysis methods for activity characterization in spatiotemporal data

    Energy Technology Data Exchange (ETDEWEB)

    Haass, Michael Joseph; Van Benthem, Mark Hilary; Ochoa, Edward M

    2014-03-01

    Tensor (multiway array) factorization and decomposition offers unique advantages for activity characterization in spatio-temporal datasets because these methods are compatible with sparse matrices and maintain multiway structure that is otherwise lost in collapsing for regular matrix factorization. This report describes our research as part of the PANTHER LDRD Grand Challenge to develop a foundational basis of mathematical techniques and visualizations that enable unsophisticated users (e.g. users who are not steeped in the mathematical details of matrix algebra and mulitway computations) to discover hidden patterns in large spatiotemporal data sets.

  11. Reactor kinetics methods development. Final report

    International Nuclear Information System (INIS)

    Hansen, K.F.; Henry, A.F.

    1978-01-01

    This report is a qualitative summary of research conducted at MIT from 1967 to 1977 in the area of reactor kinetics methods. The objectives of the research were to find methods of integration of various mathematical models of nuclear reactor transients. From the beginning the work was aimed at numerical integration methods. Specific areas of research, discussed in more detail following, included: integration of multigroup diffusion theory models by finite difference and finite element methods; response matrix and nodal methods; coarse-mesh homogenization; and special treatment of boundary conditions

  12. In silico machine learning methods in drug development.

    Science.gov (United States)

    Dobchev, Dimitar A; Pillai, Girinath G; Karelson, Mati

    2014-01-01

    Machine learning (ML) computational methods for predicting compounds with pharmacological activity, specific pharmacodynamic and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties are being increasingly applied in drug discovery and evaluation. Recently, machine learning techniques such as artificial neural networks, support vector machines and genetic programming have been explored for predicting inhibitors, antagonists, blockers, agonists, activators and substrates of proteins related to specific therapeutic targets. These methods are particularly useful for screening compound libraries of diverse chemical structures, "noisy" and high-dimensional data to complement QSAR methods, and in cases of unavailable receptor 3D structure to complement structure-based methods. A variety of studies have demonstrated the potential of machine-learning methods for predicting compounds as potential drug candidates. The present review is intended to give an overview of the strategies and current progress in using machine learning methods for drug design and the potential of the respective model development tools. We also regard a number of applications of the machine learning algorithms based on common classes of diseases.

  13. Child Development: An Active Learning Approach

    Science.gov (United States)

    Levine, Laura E.; Munsch, Joyce

    2010-01-01

    Within each chapter of this innovative topical text, the authors engage students by demonstrating the wide range of real-world applications of psychological research connected to child development. In particular, the distinctive Active Learning features incorporated throughout the book foster a dynamic and personal learning process for students.…

  14. Developing Web literacy in collaborative inquiry activities

    NARCIS (Netherlands)

    Kuiper, E.; Volman, M.L.L.; Terwel, J.

    2009-01-01

    Although many children are technically skilled in using the Web, their competences to use it in a critical and meaningful way are usually less well developed. In this article, we report on a multiple case study focusing on the possibilities and limitations of collaborative inquiry activities as an

  15. Ethical Development through Student Activities Programming.

    Science.gov (United States)

    Brock, Carol S.

    1991-01-01

    Student activities programing, viewed as essential to the college experience, is defended by outlining some of the values and growth opportunities it provides for students. Several specific programing strategies useful as catalysts in values development are described, including values clarification exercises, multicultural programing, and…

  16. Moving toward Teamwork through Professional Development Activities

    Science.gov (United States)

    Fitzgerald, Meghan M.; Theilheimer, Rachel

    2013-01-01

    This qualitative study of three Head Start Centers analyzed surveys, interviews, and focus group data to determine how education coordinators, teachers, and teacher assistants believed professional development activities could support teamwork at their centers. The researchers sorted data related to teamwork into four categories: knowledge and…

  17. ANDRA - Activity and sustainable development report 2011

    International Nuclear Information System (INIS)

    Dupuis, Marie-Claude; Gonnot, Francois-Michel; Renauld, Valerie; Sanz, Carole

    2012-07-01

    This annual report addresses the following aspects: governance (missions, localizations, institutional partners, clients, Meuse/Haute-Marne land planning scheme, underground research laboratory, Cigeo project), human resources (accident prevention, salaried personnel, customer relationship management, next steps for the Cigeo project), public service missions (polluted sites, waste confinement in Pargny-sur-Saulx, the radium diagnosis operation, a remote declaration as a new service to prepare the national inventory for 2012), industrial activities (the industrial design phase of the Cigeo project, the Manche storage centre, the Aube storage centre), environmental activities (the Observatory of the environment, the weak impact of the storage centres, the evolution of analysis laboratory of the industrial directorate), scientific policy, technological researches, experiments and developments, international activity and relationships, sustainable development, dialogue, transparency and communication, future generations, and prospective

  18. Identification of sewage leaks by active remote-sensing methods

    Science.gov (United States)

    Goldshleger, Naftaly; Basson, Uri

    2016-04-01

    The increasing length of sewage pipelines, and concomitant risk of leaks due to urban and industrial growth and development is exposing the surrounding land to contamination risk and environmental harm. It is therefore important to locate such leaks in a timely manner, to minimize the damage. Advances in active remote sensing Ground Penetrating Radar (GPR) and Frequency Domain Electromagnetic (FDEM) technologies was used to identify leaking potentially responsible for pollution and to identify minor spills before they cause widespread damage. This study focused on the development of these electromagnetic methods to replace conventional acoustic methods for the identification of leaks along sewage pipes. Electromagnetic methods provide an additional advantage in that they allow mapping of the fluid-transport system in the subsurface. Leak-detection systems using GPR and FDEM are not limited to large amounts of water, but enable detecting leaks of tens of liters per hour, because they can locate increases in environmental moisture content of only a few percentage along the pipes. The importance and uniqueness of this research lies in the development of practical tools to provide a snapshot and monitoring of the spatial changes in soil moisture content up to depths of about 3-4 m, in open and paved areas, at relatively low cost, in real time or close to real time. Spatial measurements performed using GPR and FDEM systems allow monitoring many tens of thousands of measurement points per hectare, thus providing a picture of the spatial situation along pipelines and the surrounding. The main purpose of this study was to develop a method for detecting sewage leaks using the above-proposed geophysical methods, since their contaminants can severely affect public health. We focused on identifying, locating and characterizing such leaks in sewage pipes in residential and industrial areas.

  19. Development of an active structure flight experiment

    Science.gov (United States)

    Manning, R. A.; Wyse, R. E.; Schubert, S. R.

    1993-02-01

    The design and development of the Air Force and TRW's Advanced Control Technology Experiment (ACTEX) flight experiment is described in this paper. The overall objective of ACTEX is to provide an active structure trailblazer which will demonstrate the compatibility of active structures with operational spacecraft performance and lifetime measures. At the heart of the experiment is an active tripod driven by a digitally-programmable analog control electronics subsystem. Piezoceramic sensors and actuators embedded in a graphite epoxy host material provide the sensing and actuation mechanism for the active tripod. Low noise ground-programmable electronics provide a virtually unlimited number of control schemes that can be implemented in the space environment. The flight experiment program provides the opportunity to gather performance, reliability, adaptability, and lifetime performance data on vibration suppression hardware for the next generation of DoD and NASA spacecraft.

  20. Developing students' qualitative muscles in an introductory methods course.

    Science.gov (United States)

    SmithBattle, Lee

    2014-08-30

    The exponential growth of qualitative research (QR) has coincided with methodological innovations, the proliferation of qualitative textbooks and journals, and the greater availability of qualitative methods courses. In spite of these advances, the pedagogy for teaching qualitative methods has received little attention. This paper provides a philosophical foundation for teaching QR with active learning strategies and shows how active learning is fully integrated into a one-semester course. The course initiates students into qualitative dispositions and skills as students develop study aims and procedures; enter the field to gather data; analyze the full set of student-generated data; and write results in a final report. Conducting a study in one semester is challenging but has proven feasible and disabuses students of the view that QR is simple, unscientific, or non-rigorous. Student reflections on course assignments are integrated into the paper. The strengths and limitations of this pedagogical approach are also described.

  1. Developing integrated methods to address complex resource and environmental issues

    Science.gov (United States)

    Smith, Kathleen S.; Phillips, Jeffrey D.; McCafferty, Anne E.; Clark, Roger N.

    2016-02-08

    IntroductionThis circular provides an overview of selected activities that were conducted within the U.S. Geological Survey (USGS) Integrated Methods Development Project, an interdisciplinary project designed to develop new tools and conduct innovative research requiring integration of geologic, geophysical, geochemical, and remote-sensing expertise. The project was supported by the USGS Mineral Resources Program, and its products and acquired capabilities have broad applications to missions throughout the USGS and beyond.In addressing challenges associated with understanding the location, quantity, and quality of mineral resources, and in investigating the potential environmental consequences of resource development, a number of field and laboratory capabilities and interpretative methodologies evolved from the project that have applications to traditional resource studies as well as to studies related to ecosystem health, human health, disaster and hazard assessment, and planetary science. New or improved tools and research findings developed within the project have been applied to other projects and activities. Specifically, geophysical equipment and techniques have been applied to a variety of traditional and nontraditional mineral- and energy-resource studies, military applications, environmental investigations, and applied research activities that involve climate change, mapping techniques, and monitoring capabilities. Diverse applied geochemistry activities provide a process-level understanding of the mobility, chemical speciation, and bioavailability of elements, particularly metals and metalloids, in a variety of environmental settings. Imaging spectroscopy capabilities maintained and developed within the project have been applied to traditional resource studies as well as to studies related to ecosystem health, human health, disaster assessment, and planetary science. Brief descriptions of capabilities and laboratory facilities and summaries of some

  2. Development on Vulnerability Assessment Methods of PPS

    Institute of Scientific and Technical Information of China (English)

    MIAO; Qiang; ZHANG; Wen-liang; BU; Li-xin; YIN; Hong-he; LI; Xin-jun; FANG; Xin

    2013-01-01

    Through investigating information from domestic and abroad,joint the domestic assessment experience,we present a set of physical protection system(PPS)vulnerability assessment methods for on-operating nuclear power plants and for on-designing nuclear facilities.The methods will help to strengthen and upgrade the security measures of the nuclear facilities,improve the effectiveness and

  3. Development and Application of Kinetic Spectrophotometric Method ...

    African Journals Online (AJOL)

    ISSN: 1596-5996 (print); 1596-9827 (electronic) ... Methods: The method is based on oxidation reaction of MNZ by hydrogen peroxide ... optimum operating conditions for reagent concentrations and temperature were ... 1-yl) ethanol] is an amebicide, antiprotozoal and .... The dependence of reaction rate on concentration of.

  4. Active magnetic regenerator method and apparatus

    Science.gov (United States)

    DeGregoria, Anthony J.; Zimm, Carl B.; Janda, Dennis J.; Lubasz, Richard A.; Jastrab, Alexander G.; Johnson, Joseph W.; Ludeman, Evan M.

    1993-01-01

    In an active magnetic regenerator apparatus having a regenerator bed of material exhibiting the magnetocaloric effect, flow of heat transfer fluid through the bed is unbalanced, so that more fluid flows through the bed from the hot side of the bed to the cold side than from the cold side to the hot side. The excess heat transfer fluid is diverted back to the hot side of the bed. The diverted fluid may be passed through a heat exchanger to draw heat from a fluid to be cooled. The apparatus may be operated at cryogenic temperatures, and the heat transfer fluid may be helium gas and the fluid to be cooled may be hydrogen gas, which is liquified by the device. The apparatus can be formed in multiple stages to allow a greater span of cooling temperatures than a single stage, and each stage may be comprised of two bed parts. Where two bed parts are employed in each stage, a portion of the fluid passing from the hot side to the cold side of a first bed part which does not have a magnetic field applied thereto is diverted back to the cold side of the other bed part in the stage, where it is passed through to the hot side. The remainder of the fluid from the cold side of the bed part of the first stage is passed to the hot side of the bed part of the second stage.

  5. [Educational model to develop trustworthy professional activities].

    Science.gov (United States)

    Hamui-Sutton, Alicia; Varela-Ruiz, Margarita; Ortiz-Montalvo, Armando; Torruco-García, Uri

    2015-01-01

    The reorganization of the national health system (SNS), enforces reflection and transformation on medical education in clinical contexts. The study presents an educational model to develop entrusted professionals activities (MEDAPROC) to train human resources in health with reliable knowledge, skills and attitudes to work in the shifting scenario of the SNS. The paper discusses international and national documents on skills in medicine. Based on the analysis of 8 domains, 50 skills and 13 entrusted professional activities (RPA) proposed by the Association of the American Medical College (AAMC) we propose a curriculum design, with the example of the undergraduate program of Gynecology and Obstetrics, with the intention to advance to internship and residency in a continuum that marks milestones and clinical practices. The pedagogical design of MEDAPROC was developed within three areas: 1) proposal of the AAMC; 2) curricular content of programs in pre and postgraduate education 3) organization of the daily agenda with academic mechanisms to develop the competencies, cover program items and develop clinical practice in deliberate learning activities, as well as milestones. The MEDAPROC offers versatility, student mobility and curricular flexibility in a system planed by academic units in diverse clinical settings.

  6. Study and development of a method allowing the identification of actinides inside nuclear waste packages, by active neutron or photon interrogation and delayed gamma-ray spectrometry; Etude et developpement d'une technique de dosage des actinides dans les colis de dechets radioactifs par interrogation photonique ou neutronique active et spectrometrie des gamma retardes

    Energy Technology Data Exchange (ETDEWEB)

    Carrel, F

    2007-10-15

    An accurate estimation of the alpha-activity of a nuclear waste package is necessary to select the best mode of storage. The main purpose of this work is to develop a non-destructive active method, based on the fission process and allowing the identification of actinides ({sup 235}U, {sup 238}U, {sup 239}Pu). These three elements are the main alpha emitters contained inside a package. Our technique is based on the detection of delayed gammas emitted by fission products. These latter are created by irradiation with the help of a neutron or photon beam. Performances of this method have been investigated after an Active Photon or Neutron Interrogation (INA or IPA). Three main objectives were fixed in the framework of this thesis. First, we measured many yields of photofission products to compensate the lack of data in the literature. Then, we studied experimental performances of this method to identify a given actinide ({sup 239}Pu in fission, {sup 235}U in photofission) present in an irradiated mixture. Finally, we assessed the application of this technique on different mock-up packages for both types of interrogation (118 l mock-up package containing EVA in fission, 220 l mock-up package with a wall of concrete in photofission). (author)

  7. Alternative method for quantification of alfa-amylase activity.

    Science.gov (United States)

    Farias, D F; Carvalho, A F U; Oliveira, C C; Sousa, N M; Rocha-Bezerrra, L C B; Ferreira, P M P; Lima, G P G; Hissa, D C

    2010-05-01

    A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 A degrees C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing alpha-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale alpha-amylase over a wide range (2.4 to 7,500 U.mL-1) in scientific investigation as well as in teaching laboratory activities.

  8. Alternative method for quantification of alfa-amylase activity

    Directory of Open Access Journals (Sweden)

    DF. Farias

    Full Text Available A modification of the sensitive agar diffusion method was developed for macro-scale determination of alfa-amylase. The proposed modifications lower costs with the utilisation of starch as substrate and agar as supporting medium. Thus, a standard curve was built using alfa-amylase solution from Aspergillus oryzae, with concentrations ranging from 2.4 to 7,500 U.mL-1. Clear radial diffusion zones were measured after 4 hours of incubation at 20 °C. A linear relationship between the logarithm of enzyme activities and the area of clear zones was obtained. The method was validated by testing α-amylase from barley at the concentrations of 2.4; 60; 300 and 1,500 U.mL-1. The proposed method turned out to be simpler, faster, less expensive and able to determine on a macro-scale α-amylase over a wide range (2.4 to 7,500 U.mL-1 in scientific investigation as well as in teaching laboratory activities.

  9. Development of Ultraviolet Spectrophotometric Method for Analysis ...

    African Journals Online (AJOL)

    HP

    Method for Analysis of Lornoxicam in Solid Dosage. Forms. Sunit Kumar Sahoo ... testing. Mean recovery was 100.82 % for tablets. Low values of % RSD indicate .... Saharty E, Refaat YS, Khateeb ME. Stability-. Indicating. Spectrophotometric.

  10. Development of rapid analytical methods for Sr-89/90, Pu-239/40 and Pu-238 activity concentrations in fallout, surface water, plants and aerosol filters based on modified routine used analytical procedures

    International Nuclear Information System (INIS)

    Siebert, H.-U.; Thiele, J.; Loennig, M.; Kunert, M.; Kranl, H.

    1995-01-01

    In accordance with the tasks of the National Board for Atomic Safety and Radiation Protection in the system of nuclear, environmental surveillance for many years there has existed a traditional spectrum of methods for the determination of radionuclides in environmental media. Due to the existing environmental monitoring programmes: surveillance of GDR territory with respect to the impact of global radioactive fallout; surveillance of the environment of nuclear facilities and nuclear power plants; surveillance of the environment of mining facilities, and the involved necessity of analyzing a great number of samples, the following demands were made on the radionuclide determination methods: as few as possible, simple and safe steps of analysis; use of effective nuclide selective activity measuring methods; parallel processing of several samples; possible determination of several individual nuclides by one analytic approach; selective separation methods to produce pure element-specific measuring samples, due to the necessary use of gross activity measurements; using of same principal schemes of analysis for different sample media excluding methods of decomposition

  11. Developing methods of controlling quality costs

    OpenAIRE

    Gorbunova A. V.; Maximova O. N.; Ekova V. A.

    2017-01-01

    The article examines issues of managing quality costs, problems of applying economic methods of quality control, implementation of progressive methods of quality costs management in enterprises with the view of improving the efficiency of their evaluation and analysis. With the aim of increasing the effectiveness of the cost management mechanism, authors introduce controlling as a tool of deviation analysis from the standpoint of the process approach. A list of processes and corresponding eva...

  12. Bayesian methods for proteomic biomarker development

    Directory of Open Access Journals (Sweden)

    Belinda Hernández

    2015-12-01

    In this review we provide an introduction to Bayesian inference and demonstrate some of the advantages of using a Bayesian framework. We summarize how Bayesian methods have been used previously in proteomics and other areas of bioinformatics. Finally, we describe some popular and emerging Bayesian models from the statistical literature and provide a worked tutorial including code snippets to show how these methods may be applied for the evaluation of proteomic biomarkers.

  13. Hepatitis A virus: a test method for virucidal activity.

    Science.gov (United States)

    Wolff, M H; Schmitt, J; Rahaus, M; König, A

    2001-08-01

    Hepatitis A virus (HAV) is closely related to the genus enterovirus. HAV is very stable and resistant to acid pH and elevated temperature, as well as to chemicals and environmental influences. Human poliovirus is still one of the model viruses for testing disinfectants but there are discussions about changing to hepatitis A virus. The purpose of this study was to develop a method for using adapted hepatitis A virus to test hand disinfectants. Using HAV strains HM175/24a and FRhK-4 cytopathic effects were visible rarely, and not before 14 days. To verify virus growth in cells a RT-PCR was developed. Two disinfectants tested did not show the required virucidal activity to satisfy current German guidelines.

  14. System to detect nuclear materials by active neutron method

    International Nuclear Information System (INIS)

    Koroev, M.; Korolev, Yu.; Lopatin, Yu.; Filonov, V.

    1999-01-01

    The report presents the results of the development of the system to detect nuclear materials by active neutron method measuring delayed neutrons. As the neutron source the neutron generator was used. The neutron generator was controlled by the system. The detectors were developed on the base of the helium-3 counters. Each detector consist of 6 counters. Using a number of such detectors it is possible to verify materials stored in different geometry. There is an spectrometric scintillator detector in the system which gives an additional functional ability to the system. The system could be used to estimate the nuclear materials in waste, to detect the unauthorized transfer of the nuclear materials, to estimate the material in tubes [ru

  15. Technology development activities supporting tank waste remediation

    International Nuclear Information System (INIS)

    Bonner, W.F.; Beeman, G.H.

    1994-06-01

    This document summarizes work being conducted under the U.S. Department of Energy's Office of Technology Development (EM-50) in support of the Tank Waste Remediation System (TWRS) Program. The specific work activities are organized by the following categories: safety, characterization, retrieval, barriers, pretreatment, low-level waste, and high-level waste. In most cases, the activities presented here were identified as supporting tank remediation by EM-50 integrated program or integrated demonstration lead staff and the selections were further refined by contractor staff. Data sheets were prepared from DOE-HQ guidance to the field issued in September 1993. Activities were included if a significant portion of the work described provides technology potentially needed by TWRS; consequently, not all parts of each description necessarily support tank remediation

  16. Development activities on advanced LWR in Argentina

    International Nuclear Information System (INIS)

    Gomez, S.E.

    2001-01-01

    CAREM, an Argentinean project, consists of the development, design and construction of a small Nuclear Power Plant. CAREM is an advanced reactor conceived with new generation design solutions and standing on the large experience accumulated in the safe operation of Light Water Reactors in the world. The CAREM is an indirect cycle reactor with some distinctive features that greatly simplify the reactor and also contribute to a high level of safety: integrated primary cooling system, self-pressurized, primary cooling by natural circulation and safety system relying on passive features. In this paper a brief description of the CAREM distinctive features and associated development activities are presented. (author)

  17. Development of prompt gamma activation analysis

    International Nuclear Information System (INIS)

    Olmez, I.

    1982-01-01

    Application of prompt gamma-activation analysis to some environmental samples and NBS's standard reference materials were examined, using NBS reactor and the technique developed by the nuclear chemistry group of the University of Maryland. Concentration of several elements, Cd, B, S, Se, Sb, Zn, Ba, Cr, Cs, Co, Si, Hf, Ce, Yb, Lu, Th, Sc, Eu, Fe, Ta and Rb, were determined by both PGAA and INAA. (author)

  18. The ALFA (Activity Log Files Aggregation) Toolkit: A Method for Precise Observation of the Consultation

    OpenAIRE

    de Lusignan, Simon; Kumarapeli, Pushpa; Chan, Tom; Pflug, Bernhard; van Vlymen, Jeremy; Jones, Beryl; Freeman, George K

    2008-01-01

    Background There is a lack of tools to evaluate and compare Electronic patient record (EPR) systems to inform a rational choice or development agenda. Objective To develop a tool kit to measure the impact of different EPR system features on the consultation. Methods We first developed a specification to overcome the limitations of existing methods. We divided this into work packages: (1) developing a method to display multichannel video of the consultation; (2) code and measure activities, in...

  19. Students’ intellectual development measures as an effective tool of personality development dynamics monitoring in project activities

    Directory of Open Access Journals (Sweden)

    Faleeva A.A.

    2017-04-01

    Full Text Available this article reveals the method of an educational technology project, which includes a set of research, problem of methods, creative by its very nature. The integration of knowledge is achieved by the method of projects. Individual style of student learning should be based on consideration of the individual characteristics of each student, mental development characteristics, temperament, type of nervous activity. It is important to show students their own interest to acquire the knowledge that they will need in life.

  20. Method for developing cost estimates for generic regulatory requirements

    International Nuclear Information System (INIS)

    1985-01-01

    The NRC has established a practice of performing regulatory analyses, reflecting costs as well as benefits, of proposed new or revised generic requirements. A method had been developed to assist the NRC in preparing the types of cost estimates required for this purpose and for assigning priorities in the resolution of generic safety issues. The cost of a generic requirement is defined as the net present value of total lifetime cost incurred by the public, industry, and government in implementing the requirement for all affected plants. The method described here is for commercial light-water-reactor power plants. Estimating the cost for a generic requirement involves several steps: (1) identifying the activities that must be carried out to fully implement the requirement, (2) defining the work packages associated with the major activities, (3) identifying the individual elements of cost for each work package, (4) estimating the magnitude of each cost element, (5) aggregating individual plant costs over the plant lifetime, and (6) aggregating all plant costs and generic costs to produce a total, national, present value of lifetime cost for the requirement. The method developed addresses all six steps. In this paper, we discuss on the first three

  1. Developing methods for detecting radioactive scrap

    International Nuclear Information System (INIS)

    Bellian, J.G.; Johnston, J.G.

    1995-01-01

    During the last 10 years, there have been major developments in radiation detection systems used for catching shielded radioactive sources in scrap metal. The original testing required to determine the extent of the problem and the preliminary designs of the first instruments will be discussed. Present systems available today will be described listing their advantages and disadvantages. In conclusion, the newest developments and state of the art equipment will also be included describing the limits and most appropriate locations for the systems

  2. Reducing vibration transfer from power plants by active methods

    Science.gov (United States)

    Kiryukhin, A. V.; Milman, O. O.; Ptakhin, A. V.

    2017-12-01

    The possibility of applying the methods of active damping of vibration and pressure pulsations for reducing their transfer from power plants into the environment, the seating, and the industrial premises are considered. The results of experimental works implemented by the authors on the active broadband damping of vibration and dynamic forces after shock-absorption up to 15 dB in the frequency band up to 150 Hz, of water pressure pulsations in the pipeline up to 20 dB in the frequency band up to 600 Hz, and of spatial low-frequency air noise indoors of a diesel generator at discrete frequency up to 20 dB are presented. It is shown that a reduction of vibration transfer through a vibration-isolating junction (expansion joints) of pipelines with liquid is the most complicated and has hardly been developed so far. This problem is essential for vibration isolation of power equipment from the seating and the environment through pipelines with water and steam in the power and transport engineering, shipbuilding, and in oil and gas pipelines in pumping stations. For improving efficiency, reducing the energy consumption, and decreasing the overall dimensions of equipment, it is advisable to combine the work of an active system with passive damping means, the use of which is not always sufficient. The executive component of the systems of active damping should be placed behind the vibration isolators (expansion joints). It is shown that the existence of working medium and connection of vibration with pressure pulsations in existing designs of pipeline expansion joints lead to growth of vibration stiffness of the expansion joint with the environment by two and more orders as compared with the static stiffness and makes difficulties for using the active methods. For active damping of vibration transfer through expansion joints of pipelines with a liquid, it is necessary to develop expansion joint structures with minimal connection of vibrations and pulsations and minimal

  3. Projected oriented organizations as development of enterprise management methods

    Directory of Open Access Journals (Sweden)

    S.I. Pavlova

    2016-12-01

    Full Text Available Dynamic external environment, significant shortage of product life cycle, increase of product technological difficulty, extension of innovative knowledge motivates managers to look for and use in their activities keys that will provide constant, stable development of organizational structures. The methodology of project enterprise management meets the requirements of «preservation through development». The articles researches the integration of methods and procedures of project management into the enterprise management system. Project management philosophy is the efficient way of existence in the competitive environment and the means for internal development of a company. The author conducts an analysis, determines the essence and peculiarities of a project-oriented enterprise, performs comparing characteristics of functional and project management, describes the stages of gradual transformation of an enterprise organizational structure into a project-oriented one. It is defined that a project-oriented enterprise is that one which functions on the base of innovative development and are scientific, creative and widely use the project activity as the means of a steady development. The article describes internal and external instruments of project management, base knowledge systems on project management and possibilities of enterprises on audit of state of system project management in an enterprise according to the IPMA certification program on the territory of Ukraine.

  4. Agile Service Development: A Rule-Based Method Engineering Approach

    NARCIS (Netherlands)

    dr. Martijn Zoet; Stijn Hoppenbrouwers; Inge van de Weerd; Johan Versendaal

    2011-01-01

    Agile software development has evolved into an increasingly mature software development approach and has been applied successfully in many software vendors’ development departments. In this position paper, we address the broader agile service development. Based on method engineering principles we

  5. A Simple and Accurate Method for Measuring Enzyme Activity.

    Science.gov (United States)

    Yip, Din-Yan

    1997-01-01

    Presents methods commonly used for investigating enzyme activity using catalase and presents a new method for measuring catalase activity that is more reliable and accurate. Provides results that are readily reproduced and quantified. Can also be used for investigations of enzyme properties such as the effects of temperature, pH, inhibitors,…

  6. Modern leadership and management methods for development organizations

    Directory of Open Access Journals (Sweden)

    Samosudova Natalia V.

    2017-01-01

    Full Text Available The following article represents an overview of the basic theoretical concepts of leadership and management in the framework of the organization. The main scientific approaches to leadership are described in conjunction with various leadership styles and their correlation with different levels of effectiveness as a result of the organization’s activity. Certain characteristics applicable to leaders and managers are mentioned. Attitude and obligations of a modern construction project manager are discussed, along with the challenges the construction industry represents these days. Ideas about methods of complex analysis for further research and identifying leadership tactics and their impact on the success of the development organization are suggested.

  7. Development of New Bituminous Pavement Design Method

    DEFF Research Database (Denmark)

    Ullidtz, Per

    The report and work of COST Action 333 sets in place the foundation for a coherent, cost-effective and harmonised European pavement design method. In order to do this, the work programme focused on information gathering, identification of requirements and the selection of the necessary design...

  8. Development of an indirect spectrophotometric method for ...

    African Journals Online (AJOL)

    A simple and rapid indirect spectrophotometric method for determination of ... of the colored product was measured at 405 nm and pH 3 against a reagent blank. ... The limit of detection and quantification were found to be 0.20±0.03 and ...

  9. Water flow measurements with the pulsed neutron activation method

    International Nuclear Information System (INIS)

    Linden, P.

    1997-05-01

    The objective of this work was to develop and study the feasibility of a flow-meter, based on the pulsed neutron activation method. It is a non-invasive method with good potential regarding accuracy. However, the ultimate accuracy has not been fully investigated before. Two series of flow rate measurements have been performed and analysed. The first series was done under moderately accurate flow calibration conditions to get sufficient confidence in the method and to get indication of the obtainable accuracy. The results were encouraging and further measurements with high accuracy flow calibration were planned. A dedicated loop was designed and built, and it was used with satisfactory performance. Two models have been used for analysis of recorded data; time weighting method and a fit to Taylor diffusion theory. The results show that the accuracy in mean flow velocity obtained from the used analysis models is in the range of 2-4% for Reynolds numbers greater than 10,000. Data recorded from high calibration measurements will also be used for validation of future calculations. 19 refs, 4 figs

  10. Development of cutting machine for disposal of highly activated equipments

    International Nuclear Information System (INIS)

    Iimura, Katumichi; Kitajima, Toshio; Hosokawa, Jinsaku; Abe, Shinichi; Takahashi, Kiyoshi; Ogawa, Mituhiro; Iwai, Takashi

    1994-01-01

    JMTR (Japan Materials Testing Reactor) Project has developed a cutting machine which can cut a highly activated in-pile tube under water and its performance and safety have been confirmed. This machine is for the purpose of cutting a multiplet structure pipe and made possible to cut it under water by adopting under-water discharge method. Furthermore, contamination of canal water and atmosphere is prevented by combining a filter with this machine. This report describes the outline and performance of the developed cutting machine and also results of cutting highly activated in-pile tubes. (author)

  11. Development of α and/or β activity aerosol instrumentation

    International Nuclear Information System (INIS)

    Lu Zhengyong; Li Aiwu; Gou Quanlu

    1996-01-01

    A radioactive aerosol instrumentation is developed recently for measuring the α and/or β activity of artificial radioactivity aerosols which are produced in nuclear facilities. The instrumentation has the function discriminating natural radioactivity aerosols resulted from radon and thoron daughters, and it is enabled in time and without delay to measure α and β artificial activity collected with a filter by pumping aerosols through this filter. The energy discrimination and compensation method is used for eliminating the influence of natural αradioactivity aerosols. To minimize the influence of natural β-radioactivity aerosols, the method measuring the ratio α/β of natural aerosols is also used in the instrument. The improved methods eliminating the influence of natural background α and β aerosols are used so that both α and β artificial activities in aerosol filter samples can be monitored simultaneously. The instrumentation is appropriate for monitoring α and/or β artificial radioactive aerosols

  12. Advanced Extravehicular Activity Pressure Garment Requirements Development

    Science.gov (United States)

    Ross, Amy

    2014-01-01

    The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the by what method the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun, in other cases no effort has been initiated to close the gap. Status of ongoing efforts and potential approaches to open gaps are discussed.

  13. Characterization, thermal stability studies, and analytical method development of Paromomycin for formulation development.

    Science.gov (United States)

    Khan, Wahid; Kumar, Neeraj

    2011-06-01

    Paromomycin (PM) is an aminoglycoside antibiotic, first isolated in the 1950s, and approved in 2006 for treatment of visceral leishmaniasis. Although isolated six decades back, sufficient information essential for development of pharmaceutical formulation is not available for PM. The purpose of this paper was to determine thermal stability and development of new analytical method for formulation development of PM. PM was characterized by thermoanalytical (DSC, TGA, and HSM) and by spectroscopic (FTIR) techniques and these techniques were used to establish thermal stability of PM after heating PM at 100, 110, 120, and 130 °C for 24 h. Biological activity of these heated samples was also determined by microbiological assay. Subsequently, a simple, rapid and sensitive RP-HPLC method for quantitative determination of PM was developed using pre-column derivatization with 9-fluorenylmethyl chloroformate. The developed method was applied to estimate PM quantitatively in two parenteral dosage forms. PM was successfully characterized by various stated techniques. These techniques indicated stability of PM for heating up to 120 °C for 24 h, but when heated at 130 °C, PM is liable to degradation. This degradation is also observed in microbiological assay where PM lost ∼30% of its biological activity when heated at 130 °C for 24 h. New analytical method was developed for PM in the concentration range of 25-200 ng/ml with intra-day and inter-day variability of stability of PM was determined successfully. Developed analytical method was found sensitive, accurate, and precise for quantification of PM. Copyright © 2010 John Wiley & Sons, Ltd. Copyright © 2010 John Wiley & Sons, Ltd.

  14. Current status of fluoride volatility method development

    Energy Technology Data Exchange (ETDEWEB)

    Uhlir, J.; Marecek, M.; Skarohlid, J. [UJV - Nuclear Research Institute, Research Centre Rez, CZ-250 68 Husinec - Rez 130 (Czech Republic)

    2013-07-01

    The Fluoride Volatility Method is based on a separation process, which comes out from the specific property of uranium, neptunium and plutonium to form volatile hexafluorides whereas most of fission products (mainly lanthanides) and higher transplutonium elements (americium, curium) present in irradiated fuel form nonvolatile tri-fluorides. Fluoride Volatility Method itself is based on direct fluorination of the spent fuel, but before the fluorination step, the removal of cladding material and subsequent transformation of the fuel into a powdered form with a suitable grain size have to be done. The fluorination is made with fluorine gas in a flame fluorination reactor, where the volatile fluorides (mostly UF{sub 6}) are separated from the non-volatile ones (trivalent minor actinides and majority of fission products). The subsequent operations necessary for partitioning of volatile fluorides are the condensation and evaporation of volatile fluorides, the thermal decomposition of PuF{sub 6} and the finally distillation and sorption used for the purification of uranium product. The Fluoride Volatility Method is considered to be a promising advanced pyrochemical reprocessing technology, which can mainly be used for the reprocessing of oxide spent fuels coming from future GEN IV fast reactors.

  15. Developing methods of controlling quality costs

    Directory of Open Access Journals (Sweden)

    Gorbunova A. V.

    2017-01-01

    Full Text Available The article examines issues of managing quality costs, problems of applying economic methods of quality control, implementation of progressive methods of quality costs management in enterprises with the view of improving the efficiency of their evaluation and analysis. With the aim of increasing the effectiveness of the cost management mechanism, authors introduce controlling as a tool of deviation analysis from the standpoint of the process approach. A list of processes and corresponding evaluation criteria in the quality management system of enterprises is introduced. Authors also introduce the method of controlling quality costs and propose it for the practical application, which allows them to determine useful and unnecessary costs at the existing operating plant. Implementing the proposed recommendations in the system of cost management at an enterprise will allow to improve productivity of processes operating and reduce wasted expense on the quality of the process on the basis of determining values of useful and useless costs of quality according to criteria of processes functioning in the system of quality management.

  16. Child Development in Developing Countries: Introduction and Methods

    Science.gov (United States)

    Bornstein, Marc H.; Britto, Pia Rebello; Nonoyama-Tarumi, Yuko; Ota, Yumiko; Petrovic, Oliver; Putnick, Diane L.

    2012-01-01

    The Multiple Indicator Cluster Survey (MICS) is a nationally representative, internationally comparable household survey implemented to examine protective and risk factors of child development in developing countries around the world. This introduction describes the conceptual framework, nature of the MICS3, and general analytic plan of articles…

  17. Development of standard testing methods for nuclear-waste forms

    International Nuclear Information System (INIS)

    Mendel, J.E.; Nelson, R.D.

    1981-11-01

    Standard test methods for waste package component development and design, safety analyses, and licensing are being developed for the Nuclear Waste Materials Handbook. This paper describes mainly the testing methods for obtaining waste form materials data

  18. Development of a high performance liquid chromatography method ...

    African Journals Online (AJOL)

    Development of a high performance liquid chromatography method for simultaneous ... Purpose: To develop and validate a new low-cost high performance liquid chromatography (HPLC) method for ..... Several papers have reported the use of ...

  19. Principle of coincidence method and application in activity measurement

    International Nuclear Information System (INIS)

    Li Mou; Dai Yihua; Ni Jianzhong

    2008-01-01

    The basic principle of coincidence method was discussed. The basic principle was generalized by analysing the actual example, and the condition in theory of coincidence method was brought forward. The cause of variation of efficiency curve and the effect of dead-time in activity measurement were explained using the above principle and condition. This principle of coincidence method provides the foundation in theory for activity measurement. (authors)

  20. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  1. Development of HANARO Activation Analysis System and Utilization Technology

    International Nuclear Information System (INIS)

    Chung, Y. S.; Moon, J. H.; Cho, H. J.

    2007-06-01

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility

  2. Validation of five minimally obstructive methods to estimate physical activity energy expenditure in young adults in semi-standardized settings

    DEFF Research Database (Denmark)

    Schneller, Mikkel Bo; Pedersen, Mogens Theisen; Gupta, Nidhi

    2015-01-01

    We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4), against indirect calorimetry, to estimate total energy expenditure (EE) of different activities in semi-standardized settings. Fourteen particip...

  3. Development and Validation of a Dissolution Test Method for ...

    African Journals Online (AJOL)

    Purpose: To develop and validate a dissolution test method for dissolution release of artemether and lumefantrine from tablets. Methods: A single dissolution method for evaluating the in vitro release of artemether and lumefantrine from tablets was developed and validated. The method comprised of a dissolution medium of ...

  4. Feedback of reactor operating data to nuclear methods development

    International Nuclear Information System (INIS)

    Crowther, R.L.; Kang, C.M.; Parkos, G.R.; Wolters, R.A.

    1978-01-01

    The problems in obtaining power reactor data for reliable nuclear methods development and the major sources of power reactor data for this purpose are reviewed. Specific examples of the use of power reactor data in nuclear methods development are discussed. The paper concludes with recommendations on the key elements of an effective program to use power reactor data in nuclear methods development

  5. Neutron-activation method of monitoring of the environment

    International Nuclear Information System (INIS)

    Sattarov, G.S.; Muzafarov, A.M.; Komilov, J.M.; Kadirov, F.; Kist, A.A.

    2004-01-01

    Full text: Estimation of technogenic influences of the industrial enterprises on an environment, in particular, on ground and underground waters, was carried out by the fragmentary analysis of their element structure. In the report application of neutron-activation analysis (NAA) for monitoring an environment is considered. The total contents of elements was determined by NAA method with use of a reactor such as WWR-SM. Values of factors of correlation (K) are calculated with use of the computer, by special algorithm and reception of numerical values between 30 elements in the samples selected by a traditional technique from more than 600 points in area of activity GMZ-2. The developed technique has allowed to reveal elements indicators of technogenic (As, Ag, Sb, W, Au), mixed (Mo, Ba, Hg) and natural (Sc, Fe, Co, Ni, Rb, Cs, REE, Hf, Th, U) origins. Change of the total contents of elements in underground waters which were selected from observant chinks quarterly within three years is investigated. The technique of definition of forms of a presence of elements in underground and the sewage, based on electrodialysis division of ions with use nuclear (on a basis polyethyleneterephtalate film) filters with a diameter of pores of 0,16x0,2 micrometres is developed

  6. Development of neutron activation analysis software

    International Nuclear Information System (INIS)

    Wang Liyu

    1987-10-01

    The software for quantitative neutron activation analysis was developed to run under the MS/DOS operating system. The programmes of the IBM/SPAN include: spectra file transfer from and to a Canberra Series 35 multichannel analyzer, spectrum evaluation routines, calibration subprogrammes, and quantitative analysis. The programmes for spectrum analysis include fitting routine for separation of multiple lines by reproducing the peak shape with a combination of Gaussian and exponential terms. The programmes were tested on an IBM/AT-compatible computer. The programmes and the sources are available costfree for the IAEA projects of Technical Cooperation. 7 refs, 3 figs

  7. Information system development activities and inquiring systems

    DEFF Research Database (Denmark)

    Carugati, Andrea

    2008-01-01

    This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects...... based on ISD literature and on Churchman's (1971) inquiring systems. The second part presents the use of the framework in an ISD project. The case is used to show the applicability of the framework and to highlight the advantages of this approach. The main theoretical implication is that the framework...

  8. Development of method quantitative content of dihydroquercetin. Report 1

    Directory of Open Access Journals (Sweden)

    Олександр Юрійович Владимиров

    2016-01-01

    Full Text Available Today is markedly increasing scientific interest in the study of flavonoids in plant objects due to their high biological activity. In this regard, the urgent task of analytical chemistry is in developing available analytical techniques of determination for flavonoids in plant objects.Aim. The aim was to develop specific techniques of quantitative determination for dihydroquercetin and determination of its validation characteristics.Methods. The technique for photocolorimetric quantification of DQW, which was based on the specific reaction of cyanidine chloride formation when added zinc powder to dihydroquercetin solution in an acidic medium has been elaborated.Results. Photocolorimetric technique of determining flavonoids recalculating on DQW has been developed, its basic validation characteristics have been determined. The obtained metrological characteristics of photocolorimetric technique for determining DQW did not exceed admissibility criteria in accordance with the requirements of the State Pharmacopoeia of Ukraine.Conclusions. By the results of statistical analysis of experimental data, it has been stated that the developed technique can be used for quantification of DQW. Metrological data obtained indicate that the method reproduced in conditions of two different laboratories with confidence probability 95 % unit value deviation was 101,85±2,54 %

  9. Status and development of uranium prospection methods

    International Nuclear Information System (INIS)

    Barthel, F.

    1978-01-01

    In radiometric prospection, gamma measuring equipment is widely used. Simple instruments, so-called scintillometers, can only measure total radiation while spectrometers permit separate measurements of uranium, thorium, or calcium via daughter products of their decay chains. Depending on the target investigated, airborne, carborne, or footborne methods are employed. In radon prospection the gaseous decay product radon is measured as a sign of hidden uranium enrichment in ground air or water from springs. Due to its high solubility, uranium is well suited for geochemical prospection where uranium concentrations in bodies of water, river sediments, soil and rock types are determined. There is a trend in uranium prospection towards the discovery of hidden orifications. Novel techniques, e.g. airborne geochemistry, isotope chemistry, tracer element measurement, etc. are being tested with a view to their suitability for uranium prospection. (orig./HP) 891 HP/orig.- 892 MKO [de

  10. A Scale Development for Teacher Competencies on Cooperative Learning Method

    Science.gov (United States)

    Kocabas, Ayfer; Erbil, Deniz Gokce

    2017-01-01

    Cooperative learning method is a learning method studied both in Turkey and in the world for long years as an active learning method. Although cooperative learning method takes place in training programs, it cannot be implemented completely in the direction of its principles. The results of the researches point out that teachers have problems with…

  11. Instrument pre-development activities for FLEX

    Science.gov (United States)

    Pettinato, L.; Fossati, E.; Coppo, P. M.; Taiti, A.; Labate, D.; Capanni, A.; Taccola, M.; Bézy, J. L.; Francois, M.; Meynart, R.; Erdmann, L.; Triebel, P.

    2017-09-01

    The FLuorescence Imaging Spectrometer (FLORIS) is the payload of the FLuorescence Explorer Mission (FLEX) of the European Space Agency. The mission objective is to perform quantitative measurements of the solar induced vegetation fluorescence to monitor photosynthetic activity. FLORIS works in a push-broom configuration and it is designed to acquire data in the 500-780 nm spectral range, with a sampling of 0.1 nm in the oxygen bands (759-769 nm and 686- 697 nm) and 0.5-2.0 nm in the red edge, chlorophyll absorption and Photochemical Reflectance Index bands. FLEX will fly in formation with Sentinel-3 to benefit of the measurements made by the Sentinel-3 instruments OLCI and SLSTR, particularly for cloud screening, proper characterization of the atmospheric state and determination of the surface temperature. The instrument concept is based on a common telescope and two modified Offner spectrometers with reflective concave gratings both for the High Resolution (HR) and Low Resolution (LR) spectrometers. In the frame of the instrument pre-development Leonardo Company (I) has built and tested an elegant breadboard of the instrument consisting of the telescope and the HR spectrometer. The development of the LR spectrometer is in charge of OHB System AG (D) and is currently in the manufacturing phase. The main objectives of the activity are: anticipate the development of the instrument and provide early risk retirement of critical components, evaluate the system performances such as imaging quality parameters, straylight, ghost, polarization sensitivity and environmental influences, verify the adequacy of critical tests such as spectral characterization and straylight, define and optimize instrument alignment procedures. Following a brief overview of the FLEX mission, the paper will cover the design and the development of the optics breadboard with emphasis on the results obtained during the tests and the lessons learned for the flight unit.

  12. Communication Systems and Study Method for Active Distribution Power systems

    DEFF Research Database (Denmark)

    Wei, Mu; Chen, Zhe

    Due to the involvement and evolvement of communication technologies in contemporary power systems, the applications of modern communication technologies in distribution power system are becoming increasingly important. In this paper, the International Organization for Standardization (ISO......) reference seven-layer model of communication systems, and the main communication technologies and protocols on each corresponding layer are introduced. Some newly developed communication techniques, like Ethernet, are discussed with reference to the possible applications in distributed power system....... The suitability of the communication technology to the distribution power system with active renewable energy based generation units is discussed. Subsequently the typical possible communication systems are studied by simulation. In this paper, a novel method of integrating communication system impact into power...

  13. Developments of methods for computerized configuration control

    International Nuclear Information System (INIS)

    Kafka, P.

    1997-01-01

    It is known that Probabilistic Safety Assessment (PSA) is nowadays the appropriate technology and tool that can be used to optimize, during the design phase, a considered installation taking into account reliability and safety aspects, and also to evaluate and quantify the base-line risk level for the optimized installation. This base-line risk level is normally expressed by an average frequency per plant-year assigned to a scenario of interest (e.g. core damage, in case of a NPP). A considerable number of changes in components and system design can occur during the construction phase and another during the subsequent operation phase due to a continuous change in the plant configurations and their operating procedures, when compared to the configuration considered for the base-line risk quantification. These changes can be originated by planned activities like tests, maintenance and repair or by unplanned actions, mainly random events (failures) on components and systems. This results in a fluctuation of the risk level over operating time and is denominated as the ''risk profile'' (RP) of the installation. Living PSA and risk monitoring programs can assess the RP. An adequate management tool, calculating the ''risk profile'', can be used to control and optimize the operation of the installation with respect to a minimal risk level over the operating time. As a result we obtained a so called fault tolerant operation. 30 refs, 1 tab, figs

  14. Extremely Randomized Machine Learning Methods for Compound Activity Prediction

    Directory of Open Access Journals (Sweden)

    Wojciech M. Czarnecki

    2015-11-01

    Full Text Available Speed, a relatively low requirement for computational resources and high effectiveness of the evaluation of the bioactivity of compounds have caused a rapid growth of interest in the application of machine learning methods to virtual screening tasks. However, due to the growth of the amount of data also in cheminformatics and related fields, the aim of research has shifted not only towards the development of algorithms of high predictive power but also towards the simplification of previously existing methods to obtain results more quickly. In the study, we tested two approaches belonging to the group of so-called ‘extremely randomized methods’—Extreme Entropy Machine and Extremely Randomized Trees—for their ability to properly identify compounds that have activity towards particular protein targets. These methods were compared with their ‘non-extreme’ competitors, i.e., Support Vector Machine and Random Forest. The extreme approaches were not only found out to improve the efficiency of the classification of bioactive compounds, but they were also proved to be less computationally complex, requiring fewer steps to perform an optimization procedure.

  15. Development methods for VLSI-processors

    International Nuclear Information System (INIS)

    Horninger, K.; Sandweg, G.

    1982-01-01

    The aim of this project, which was originally planed for 3 years, was the development of modern system and circuit concepts, for VLSI-processors having a 32 bit wide data path. The result of this first years work is the concept of a general purpose processor. This processor is not only logically but also physically (on the chip) divided into four functional units: a microprogrammable instruction unit, an execution unit in slice technique, a fully associative cache memory and an I/O unit. For the ALU of the execution unit circuits in PLA and slice techniques have been realized. On the basis of regularity, area consumption and achievable performance the slice technique has been prefered. The designs utilize selftesting circuitry. (orig.) [de

  16. Methods and Protocols for Developing Prion Vaccines.

    Science.gov (United States)

    Marciniuk, Kristen; Taschuk, Ryan; Napper, Scott

    2016-01-01

    Prion diseases denote a distinct form of infectivity that is based in the misfolding of a self-protein (PrP(C)) into a pathological, infectious conformation (PrP(Sc)). Efforts to develop vaccines for prion diseases have been complicated by the potential dangers that are associated with induction of immune responses against a self-protein. As a consequence, there is considerable appeal for vaccines that specifically target the misfolded prion conformation. Such conformation-specific immunotherapy is made possible through the identification of vaccine targets (epitopes) that are exclusively presented as a consequence of misfolding. An immune response directed against these targets, termed disease-specific epitopes (DSEs), has the potential to spare the function of the native form of the protein while clearing, or neutralizing, the infectious isomer. Although identification of DSEs represents a critical first step in the induction of conformation-specific immune responses, substantial efforts are required to translate these targets into functional vaccines. Due to the poor immunogenicity that is inherent to self-proteins, and that is often associated with short peptides, substantial efforts are required to overcome tolerance-to-self and maximize the resultant immune response following DSE-based immunization. This often includes optimization of target sequences in terms of immunogenicity and development of effective formulation and delivery strategies for the associated peptides. Further, these vaccines must satisfy additional criteria from perspectives of specificity (PrP(C) vs. PrP(Sc)) and safety (antibody-induced template-driven misfolding of PrP(C)). The emphasis of this report is on the steps required to translate DSEs into prion vaccines and subsequent evaluation of the resulting immune responses.

  17. Active learning innovative for the study of climatic variations in Sicily (Italy) and micro-climates in confined environments. Digitized construction of agro-meteorological laboratory and entrepreneurial development of methodical home automation systems

    Science.gov (United States)

    Crimi, Pietro

    2017-04-01

    In education to issues of environmental sustainability and the use of renewable energy resources, there are the existing laboratory teaching methodologies in Superior School "A. Volta" in Palermo (Italy) for acquisition, processing and control network of agro-meteorological data on the local area. This station was planned to allow students practical multidisciplinary learning experiences in the field of agro-meteorological applications. The School started a few months ago a project of MIUR (Italian Ministry of Education) that updates the lab through the most innovative digital technologies in the field of mechatronics, domotic and sustainable energy, that are supported by the latest needs of scientific-educational multimedia. It is an educational training that intends to implement a data collection center agro-meteorological on "digital platforms," informational purposes and applications, on current issues of climate changes and their consequences in Sicily (Italy). This active learning will interconnect the data collected from the station weather and climate of the school with those locally and regionally, with "weather-climatic patterns" correlations that are implemented in the Mediterranean area (International Program "GAW-Global Atmosphere Watch"). For this reason were enabled synergies with two major public scientific research and acquisition services-data disclosure (ENEA and SIAS-Agrometeorological Information Service, Sicily Region), both to energy efficiency of the School Station, both to support data and digital applications in GIS, with agro-meteorological services to companies operating in the agricultural and environmental sustainability, high consideration themes in European Programming. A branch of this training course is the entrepreneurship education, carried out by a few years in School with the development of "experimental models" for the creation of "innovation clusters" to make entrepreneurial experience since school, creating/managing mini

  18. Development of circular filters for active facilities

    International Nuclear Information System (INIS)

    Pratt, R.P.

    1986-01-01

    An assessment of problems associated with remote handling, changing and disposal of filters suggested that significant improvements to filtration systems could be made if circular geometries were adopted in place of conventional systems. Improved systems have been developed and are now available for a range of applications and air flow rates. Where primary filters are installed within the active cell or cave, circular filters incorporating a lip seal have been developed which enable the filters to be sealed into the facility without recourse to clamping. For smaller cells, a range of push-through filter change systems have been developed, the principal feature being that the filter is passed into the housing from the clean side, but transferred from the housing directly into the cell for subsequent disposal. For plant room applications, circular bag change canister systems have been developed which ease the sealing and bag change operation. Such systems have a rated air flow of up to 3000 m 3 /h whilst still allowing ultimate disposal via the 200 litre waste drum route without prior volume reduction of the filter inserts. (author)

  19. ENTREPRENEURIAL ACTIVITY IN THE CONDITIONS OF PRIORITY DEVELOPMENT AREAS

    Directory of Open Access Journals (Sweden)

    E. V. Gruzdeva

    2016-01-01

    Full Text Available This article presents an analysis of the most important issues in priority development areas, including the commitment of the Kamchatka region in which such territory is focused primarily on the development of tourism. The relevance of the article due to the increase in the activity of creation of territories of operahouse development in Russia.Goal/objectives. The purpose of this article is to identify both advantages and disadvantages of priority development areas as a mechanism of economic development. To achieve this goal, the author formulated and solved two tasks – analysis of theoretical questions of development of territories of priority development and evaluation of a practical example of creating such a site.Methodology. The theoretical basis of the research was normative legal acts devoted to the question of priority development areas and strategic documents of the Kamchatka region. As a methodological basis of applied methods: analysis, synthesis, analogy, comparison, induction and deduction.Results. Found that despite the existing shortcomings and limitations, the creation of territories of priority development is an eff ective tool for the development of entrepreneurship.Conclusions/significance. Creation within the country's territory, favorable for attracting long-term investment, is a widespread global practice to attract large companies. In Russia, this tool is relatively new, but is already actively used for the development of entrepreneurial activities in troubled regions.This tool provides its residents with sufficient opportunities to gain competitive advantage, accordingly, is a critical study of all questions of implementation and follow-up work of priority development areas, given companies' business activities both within and outside the area.

  20. Development of the European activation system

    Energy Technology Data Exchange (ETDEWEB)

    Forrest, Robin [Euratom/UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxfordshire (United Kingdom); Kopecky, Jiri [JUKO Research (Netherlands); Sublet, Jean-Christophe [CEA, Service de Physique des Reacteurs et du Cycle, Saint Paul Lez Durance (France)

    2002-08-01

    The ability to predict the effects of neutron irradiation on an arbitrary material is a fundamental need of fusion technology. The European Fusion Technology Programme has long recognised this fact, and has developed the European Activation System (EASY). This integrated package relies on research in several areas and can be described as an example of successful international co-operation. Modern software tools were used to produce a user-friendly application (SAFEPAQ-II) running under Windows-98 or NT in which all nuclear data are stored in relational databases. Cross section data from almost 50 sources are read and converted from standard formats to databases. By a series of manipulations these data are selected, modified and processed to yield SAFEPAQ-II databases. All reactions can be graphically displayed with experimental data and uncertainty estimates. Following internal validation and processing the data can then be written out in standard EAF (European Activation File) format (including a set of nine multi-group files) ready for use by the FISPACT inventory code. The various EAF data libraries have been extensively validated against integral measurements using fusion relevant materials and three complementary neutron spectra. Results from such studies have also been fed back to improve library development. New user tools allow the graphical viewing of all multi-group cross sections and decay data. User feedback on bugs and new options have been incorporated in EASY-2001 which is fully documented and provides a complete and reliable tool for prediction of activation in fusion and other applications. (J.P.N.)

  1. Developing methods for establishing improved plant reliability

    International Nuclear Information System (INIS)

    Zebroski, E.L.; Lapides, M.E.; Johnson, L.

    1976-01-01

    The current average capacity factor for nuclear electric generating facilities is approximately 60 percent, virtually the same as that for large, modern fossil-fired units. There is a clear cost advantage for nuclear electrical generation in comparison to coal-fired units at a common performance level. Because of the accelerated increase in capital and fuel costs of coal-fired units, the nuclear units will usually exhibit a cost advantage even when operating at lower capacity factor values. The incentives for improvement follow from the utility objectives to provide electricity at the most economical rates possible and are reflected in reduced system fuel costs and capital requirements. These objectives require maximizing the productivity of existing or planned investments in nuclear generation. The requirements are to: (1) achieve and sustain the highest capacity factor consistent with each utility's electric transmission system configuration and demand; (2) accelerate the rate of attainment of operational ''maturity'' of new generation; and (3) avoid low-probability but large-consequence forced-outage events. Nuclear unit productivity improvement involves utilities, regulatory agencies and industrial and government research and development organizations; the efforts appropriate to each organization were identified in a previous study. Since no foreseeable set of warranties begins to cover the consequential costs of low performance, the greatest incentive for improvement rests with each individual utility. The paper addresses the methodology and information sources for productivity actions by utilities during unit procurement and design phases

  2. Development and validation of an ICP-MS method for the determination of elemental impurities in TP-6076 active pharmaceutical ingredient (API) according to USP 〈232〉/〈233〉.

    Science.gov (United States)

    Chahrour, Osama; Malone, John; Collins, Mark; Salmon, Vrushali; Greenan, Catherine; Bombardier, Amy; Ma, Zhongze; Dunwoody, Nick

    2017-10-25

    The new guidelines of the United States pharmacopeia (USP), European pharmacopeia (EP) and international conference on harmonization (ICH) regulating elemental impurities limits in pharmaceuticals signify the end of unspecific analysis of metals as outlined in USP 〈231〉. The new guidelines specify both daily doses and concentration/limits of elemental impurities in pharmaceutical final products, active pharmaceutical ingredients (API) and excipients. In chapter USP 〈233〉 method implementation, validation and quality control during the analytical process are described. We herein report the use of a stabilising matrix that overcomes low spike recovery problem encountered with Os and allows the determination of all USP required elemental impurities (As, Cd, Hg, Pb, V, Cr, Ni, Mo, Cu, Pt, Pd, Ru, Rh, Os and Ir) in a single analysis. The matrix was used in the validation of a method to determine elemental impurities in TP-6076 active pharmaceutical ingredient (API) by ICP-MS according to the procedures defined in USP〈233〉 and to GMP requirements. This validation will support the regulatory submission of TP-6076 which is a novel tetracycline analogue effective against the most urgent multidrug-resistant gram-negative bacteria. Evaluation of TP-6076 in IND-enabling toxicology studies has led to the initiation of a phase 1 clinical trial. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. A concern-based method to prioritize spill response activities

    International Nuclear Information System (INIS)

    Lamarche, A.; Bart, H.

    2002-01-01

    The Shoreline Cleanup Assessment Team (SCAT) of the Emergencies Division of Environment Canada in the Ontario Region developed a computerized method to help rank segments of shoreline according to levels of concern in the event of an oil spill. The original SCAT approach was designed to allow survey teams to acquire information about the state of shoreline spills so that assessments of oilings would be comparable in time and space. The SCAT method, which allows several decision makers to obtain an unbiased evaluation of the oiling situation, has been recognized in both Canada and the United States as a method that ensures the consistency of data gathering and processing for prioritization purposes. The concern-based prioritization system was integrated within the computerized response tools used by the SCAT team using tools such as the Great Lakes Electronic Environmental Sensitivities Atlas (GLEESA), a geographic information system (GIS) of environmental data, and Shore Assess, a GIS based computerized system used to provide support during a response phase of a spill. It was noted that this method is considered to be a practical response tool designed around the principles of performance support and cybernetics to help decision makers set priorities. It is not designed for pre-impact assessment. Instead, it ensures that existing knowledge of the spill characteristics and environmental conditions are used in a consistent and logical method to prioritize contingency plans. The factors used to evaluate concern for oiling, shoreline type and land use were described. Factors for concern assessment of biological organisms include the status of organisms as being either endangered, threatened, vulnerable, special concern, or not at risk. Characteristics of the species, potential effect of the pollutant and potential effect from response activities are other factors for concern. The method evaluates the concern for every category using a simple algorithm which is

  4. Studying Children’s friendship activities ethically using the Interaction Based Observation Method

    DEFF Research Database (Denmark)

    Sørensen, Hanne Værum

    2018-01-01

    The aim of this chapter is to acknowledge the influence that the interaction based observation method developed by Mariane Hedegaard has had on my studies of young children’s friendship activities. Hedegaard has problematized how existing methods of evaluating children’s development were inadequate...

  5. Evaluating a physician leadership development program - a mixed methods approach.

    Science.gov (United States)

    Throgmorton, Cheryl; Mitchell, Trey; Morley, Tom; Snyder, Marijo

    2016-05-16

    Purpose - With the extent of change in healthcare today, organizations need strong physician leaders. To compensate for the lack of physician leadership education, many organizations are sending physicians to external leadership programs or developing in-house leadership programs targeted specifically to physicians. The purpose of this paper is to outline the evaluation strategy and outcomes of the inaugural year of a Physician Leadership Academy (PLA) developed and implemented at a Michigan-based regional healthcare system. Design/methodology/approach - The authors applied the theoretical framework of Kirkpatrick's four levels of evaluation and used surveys, observations, activity tracking, and interviews to evaluate the program outcomes. The authors applied grounded theory techniques to the interview data. Findings - The program met targeted outcomes across all four levels of evaluation. Interview themes focused on the significance of increasing self-awareness, building relationships, applying new skills, and building confidence. Research limitations/implications - While only one example, this study illustrates the importance of developing the evaluation strategy as part of the program design. Qualitative research methods, often lacking from learning evaluation design, uncover rich themes of impact. The study supports how a PLA program can enhance physician learning, engagement, and relationship building throughout and after the program. Physician leaders' partnership with organization development and learning professionals yield results with impact to individuals, groups, and the organization. Originality/value - Few studies provide an in-depth review of evaluation methods and outcomes of physician leadership development programs. Healthcare organizations seeking to develop similar in-house programs may benefit applying the evaluation strategy outlined in this study.

  6. Milestones in the Development of Iterative Solution Methods

    Directory of Open Access Journals (Sweden)

    Owe Axelsson

    2010-01-01

    Full Text Available Iterative solution methods to solve linear systems of equations were originally formulated as basic iteration methods of defect-correction type, commonly referred to as Richardson's iteration method. These methods developed further into various versions of splitting methods, including the successive overrelaxation (SOR method. Later, immensely important developments included convergence acceleration methods, such as the Chebyshev and conjugate gradient iteration methods and preconditioning methods of various forms. A major strive has been to find methods with a total computational complexity of optimal order, that is, proportional to the degrees of freedom involved in the equation. Methods that have turned out to have been particularly important for the further developments of linear equation solvers are surveyed. Some of them are presented in greater detail.

  7. 24 CFR 1003.203 - Special economic development activities.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Special economic development... Eligible Activities § 1003.203 Special economic development activities. A grantee may use ICDBG funds for special economic development activities in addition to other activities authorized in this subpart which...

  8. Empirical Evidence or Intuition? An Activity Involving the Scientific Method

    Science.gov (United States)

    Overway, Ken

    2007-01-01

    Students need to have basic understanding of scientific method during their introductory science classes and for this purpose an activity was devised which involved a game based on famous Monty Hall game problem. This particular activity allowed students to banish or confirm their intuition based on empirical evidence.

  9. A Survey of Formal Methods in Software Development

    DEFF Research Database (Denmark)

    Bjørner, Dines

    2012-01-01

    The use of formal methods and formal techniques in industry is steadily growing. In this survey we shall characterise what we mean by software development and by a formal method; briefly overview a history of formal specification languages - some of which are: VDM (Vienna Development Method, 1974...... need for multi-language formalisation (Petri Nets, MSC, StateChart, Temporal Logics); the sociology of university and industry acceptance of formal methods; the inevitability of the use of formal software development methods; while referring to seminal monographs and textbooks on formal methods....

  10. Development of smart active layer sensor

    International Nuclear Information System (INIS)

    Lee, Young Sup; Lee, Sang Il; Yoon, Dong Jin; Kwon, Jae Hwa

    2004-01-01

    Structural health monitoring (SHM) is a new technology that will be increasingly applied at the industrial field as a potential approach to improve cost and convenience of structural inspection. Recently, the development of smart sensor is very active for real application. This study has focused on preparation and application study of SAL sensor. In order to detect elastic wave, smart piezoelectric sensor, SAL, is fabricated by using a piezoelectric element, shielding layer and protection layer. This protection layer plays an important role in a patched network of distributed piezoelectric sensor and shielding treatment. Four types of SAL sensor are designed/prepared/tested, and these details will be discussed in the paper. In this study, SAL sensor can be feasibly applied to perform structural health monitoring and to detect damage sources which result in elastic waves.

  11. Active solar heating industry development study

    International Nuclear Information System (INIS)

    1995-01-01

    Despite the fact that solar water heating systems are technologically viable and commercially available, this Energy Technology Support Unit report shows that there is no established market in the United Kingdom. The Solar Trade Association (STA) has undertaken an Active Solar Heating Industry Development Study which is reported here. The data is derived from a questionnaire survey completed by companies, organizations and individuals operating within the industry. Information was also gathered from utility companies, and STAs elsewhere in Europe. Barriers which need to be overcome include lack of public awareness, especially in the construction industry, lack of capital investment and other financial disincentives, little or no government support, and lack of organization and quality monitoring and assurance within the industry itself. (UK)

  12. COMPARATIVE STUDIES OF THREE METHODS FOR MEASURING PEPSIN ACTIVITY

    Science.gov (United States)

    Loken, Merle K.; Terrill, Kathleen D.; Marvin, James F.; Mosser, Donn G.

    1958-01-01

    Comparison has been made of a simple method originated by Absolon and modified in our laboratories for assay of proteolytic activity using RISA (radioactive iodinated serum albumin—Abbott Laboratories), with the commonly used photometric methods of Anson and Kunitz. In this method, pepsin was incubated with an albumin substrate containing RISA, followed by precipitation of the undigested substrate with trichloroacetic acid and measurement of radioactive digestion products in the supernatant fluid. The I131—albumin bond was shown in the present studies to be altered only by the proteolytic activity, and not by the incubation procedures at various values of pH. Any free iodine present originally in the RISA was removed by a single passage through a resin column (amberlite IRA-400-C1). Pepsin was shown to be most stable in solution at a pH of 5.5. Activity of pepsin was shown to be maximal when it was incubated with albumin at a pH of 2.5. Pepsin activity was shown to be altered in the presence of various electrolytes. Pepsin activity measured by the RISA and Anson methods as a function of concentration or of time of incubation indicated that these two methods are in good agreement and are equally sensitive. Consistently smaller standard errors were obtained by the RISA method of pepsin assay than were obtained with either of the other methods. PMID:13587910

  13. Pattern recognition in complex activity travel patterns : comparison of Euclidean distance, signal-processing theoretical, and multidimensional sequence alignment methods

    NARCIS (Netherlands)

    Joh, C.H.; Arentze, T.A.; Timmermans, H.J.P.

    2001-01-01

    The application of a multidimensional sequence alignment method for classifying activity travel patterns is reported. The method was developed as an alternative to the existing classification methods suggested in the transportation literature. The relevance of the multidimensional sequence alignment

  14. Improvement of extraction method of coagulation active components from Moringa oleifera seed

    OpenAIRE

    Okuda, Tetsuji; Baes, Aloysius U.; Nishijima, Wataru; Okada, Mitsumasa

    1999-01-01

    A new method for the extraction of the active coagulation component from Moringa oleifera seeds was developed and compared with the ordinary water extraction method (MOC–DW). In the new method, 1.0 mol l-1 solution of sodium chloride (MOC–SC) and other salts were used for extraction of the active coagulation component. Batch coagulation experiments were conducted using 500 ml of low turbid water (50 NTU). Coagulation efficiencies were evaluated based on the dosage required to remove kaolinite...

  15. Development of methods for DSM and distribution automation planning

    International Nuclear Information System (INIS)

    Kaerkkaeinen, S.; Kekkonen, V.; Rissanen, P.

    1998-01-01

    Demand-Side Management (DSM) is usually an utility (or sometimes governmental) activity designed to influence energy demand of customers (both level and load variation). It includes basic options like strategic conservation or load growth, peak clipping. Load shifting and fuel switching. Typical ways to realize DSM are direct load control, innovative tariffs, different types of campaign etc. Restructuring of utility in Finland and increased competition in electricity market have had dramatic influence on the DSM. Traditional ways are impossible due to the conflicting interests of generation, network and supply business and increased competition between different actors in the market. Costs and benefits of DSM are divided to different companies, and different type of utilities are interested only in those activities which are beneficial to them. On the other hand, due to the increased competition the suppliers are diversifying to different types of products and increasing number of customer services partly based on DSM are available. The aim of this project was to develop and assess methods for DSM and distribution automation planning from the utility point of view. The methods were also applied to case studies at utilities

  16. Development of methods for DSM and distribution automation planning

    Energy Technology Data Exchange (ETDEWEB)

    Kaerkkaeinen, S; Kekkonen, V [VTT Energy, Espoo (Finland); Rissanen, P [Tietosavo Oy (Finland)

    1998-08-01

    Demand-Side Management (DSM) is usually an utility (or sometimes governmental) activity designed to influence energy demand of customers (both level and load variation). It includes basic options like strategic conservation or load growth, peak clipping. Load shifting and fuel switching. Typical ways to realize DSM are direct load control, innovative tariffs, different types of campaign etc. Restructuring of utility in Finland and increased competition in electricity market have had dramatic influence on the DSM. Traditional ways are impossible due to the conflicting interests of generation, network and supply business and increased competition between different actors in the market. Costs and benefits of DSM are divided to different companies, and different type of utilities are interested only in those activities which are beneficial to them. On the other hand, due to the increased competition the suppliers are diversifying to different types of products and increasing number of customer services partly based on DSM are available. The aim of this project was to develop and assess methods for DSM and distribution automation planning from the utility point of view. The methods were also applied to case studies at utilities

  17. Methods of Modelling Marketing Activity on Software Sales

    Directory of Open Access Journals (Sweden)

    Bashirov Islam H.

    2013-11-01

    Full Text Available The article studies a topical issue of development of methods of modelling marketing activity on software sales for achievement of efficient functioning of an enterprise. On the basis of analysis of the market type for the studied CloudLinux OS product, the article identifies the market structure type: monopolistic competition. To ensure the information basis of the marketing activity in the target market segment, the article offers the survey method. The article provides a questionnaire, which contains specific questions regarding the studied market segment of hosting services, for an online survey with the help of the Survio service. In accordance with the system approach the CloudLinux OS has properties of systems, namely, diversity. Economic differences are non-price indicators that have no numeric expression and are quality descriptions. Analysis of the market and the conducted survey allow obtaining them. Combination of price and non-price indicators provides a complete description of the product properties. To calculate an integral indicator of competitiveness the article offers to apply a model, which is based on the direct algebraic addition of weight measures of individual indicators, regulation of formalised indicators and use of the mechanism of fuzzy sets for identification of non-formalised indicators. The calculated indicator allows not only assessment of the current level of competitiveness, but also identification of influence of changes of various indicators, which allows increase of efficiency of marketing decisions. Also, having identified the target customers of hosting OS and formalised non-price parameters, it is possible to conduct the search for a set of optimal characteristics of the product. In the result an optimal strategy of the product advancement to the market is formed.

  18. [A reliability growth assessment method and its application in the development of equipment in space cabin].

    Science.gov (United States)

    Chen, J D; Sun, H L

    1999-04-01

    Objective. To assess and predict reliability of an equipment dynamically by making full use of various test informations in the development of products. Method. A new reliability growth assessment method based on army material system analysis activity (AMSAA) model was developed. The method is composed of the AMSAA model and test data conversion technology. Result. The assessment and prediction results of a space-borne equipment conform to its expectations. Conclusion. It is suggested that this method should be further researched and popularized.

  19. Neutron activation analysis of certified samples by the absolute method

    Science.gov (United States)

    Kadem, F.; Belouadah, N.; Idiri, Z.

    2015-07-01

    The nuclear reactions analysis technique is mainly based on the relative method or the use of activation cross sections. In order to validate nuclear data for the calculated cross section evaluated from systematic studies, we used the neutron activation analysis technique (NAA) to determine the various constituent concentrations of certified samples for animal blood, milk and hay. In this analysis, the absolute method is used. The neutron activation technique involves irradiating the sample and subsequently performing a measurement of the activity of the sample. The fundamental equation of the activation connects several physical parameters including the cross section that is essential for the quantitative determination of the different elements composing the sample without resorting to the use of standard sample. Called the absolute method, it allows a measurement as accurate as the relative method. The results obtained by the absolute method showed that the values are as precise as the relative method requiring the use of standard sample for each element to be quantified.

  20. Application of thin layer activation method to industrial use

    International Nuclear Information System (INIS)

    Yamamoto, Masago; Hatakeyama, Noriko

    1996-01-01

    A thin layer activation method was reviewed for non-destructive, rapid, precise and real-time measurement of wear and corrosion. The review included wear measurement, the principle of the method, actual measurement, application, and laws and regulations. The method is to activate the material surface alone by accelerated ions like p, d and He ions produced by cyclotron, Van de Graaf apparatus or other accelerators and to utilize the yielded radioisotopes as a tracer, is widely used in the tribology field, and is more useful than the previous method with the reactor since it activated the whole material. Application of the method was reportedly resulted in saving the 80% cost and 90% time in the wear measurement of automobile parts such as engine and transmission. Actually, the activated material was combined into the part to be run and the radioactivity was to be measured externally or in the worn particles suitably collected. The activation thickness was generally in the range of 10-200 μm and the resultant radioactivity, 0.2-2 MBq. In most cases in Japan, the method would be under the law concerning prevention from radiation hazards due to radioisotopes, etc. (K.H.)

  1. Antimicrobial Testing Methods & Procedures Developed by EPA's Microbiology Laboratory

    Science.gov (United States)

    We develop antimicrobial testing methods and standard operating procedures to measure the effectiveness of hard surface disinfectants against a variety of microorganisms. Find methods and procedures for antimicrobial testing.

  2. Development of Reverse-Phase HPLC Method for Simultaneous ...

    African Journals Online (AJOL)

    Erah

    Purpose: To develop a simple, sensitive and rapid reverse phase HPLC method for the simultaneous analysis of metoprolol succinate and hydrochlorothiazide in a solid dosage form. Methods: The .... Extraction was carried out three times with.

  3. developed algorithm for the application of british method of concret

    African Journals Online (AJOL)

    t-iyke

    Most of the methods of concrete mix design developed over the years were geared towards manual approach. ... Key words: Concrete mix design; British method; Manual Approach; Algorithm. ..... Statistics for Science and Engineering.

  4. System Identification Methods for Aircraft Flight Control Development and Validation

    Science.gov (United States)

    1995-10-01

    System-identification methods compose a mathematical model, or series of models, : from measurements of inputs and outputs of dynamic systems. This paper : discusses the use of frequency-domain system-identification methods for the : development and ...

  5. Development and validation of a spectroscopic method for the ...

    African Journals Online (AJOL)

    Development and validation of a spectroscopic method for the simultaneous analysis of ... advanced analytical methods such as high pressure liquid ..... equipment. DECLARATIONS ... high-performance liquid chromatography. J Chromatogr.

  6. Quantitative analyses of impurity silicon-carbide (SiC) and high-purity-titanium by neutron activation analyses based on k0-standardization method. Development of irradiation silicon technology in productivity using research reactor (Joint research)

    International Nuclear Information System (INIS)

    Motohashi, Jun; Takahashi, Hiroyuki; Magome, Hirokatsu; Sasajima, Fumio; Tokunaga, Okihiro; Kawasaki, Kozo; Onizawa, Koji; Isshiki, Masahiko

    2009-07-01

    JRR-3 and JRR-4 have been providing neutron-transmutation-doped silicon (NTD-Si) by using the silicon NTD process, which is a method to produce a high quality semiconductor. The domestic supply of NTD-Si is insufficient for the demand, and the market of NTD-Si is significantly growing at present. It is very important to increase achieve the production. To fulfill the requirement, we have been investigating a neutron filter, which is made of high-purity-titanium, for uniform doping. Silicon-carbide (SiC) semiconductor doped with NTD technology is considered suitable for high power devices with superior performances to conventional Si-based devices. We are very interested in the SiC as well. This report presents the results obtained after the impurity contents in the high-purity-titanium and SiC were analyzed by neutron activation analyses (NAA) using k 0 -standardization method. There were 6 and 9 impurity elements detected from the high-purity-titanium and SiC, respectively. Among those Sc from the high-purity-titanium and Fe from SiC were comparatively long half life nuclides. From the viewpoint of exposure in handling them, we need to examine the impurity control of materials. (author)

  7. Production of isomers by the cyclic activation method

    International Nuclear Information System (INIS)

    Salaita, G.N.; Eapen, P.K.

    1974-01-01

    The isomeric states formation cross sections for 14.8 MeV neutron reactions in Mg, Al, As, Y, In, Hf, Tl, Pb, and Bi were measured using the cyclic activation technique and a high resolution Ge(Li) detector. Isomeric activities originating from the various isotopes of lead and thallium were separated by proper choice of cyclic timing parameters and energy discrimination. Long lived isomeric and ground state activities were investigated through conventional activation method. The isomeric cross section ratios, sigma/sub m//sigma/sub g/ for six elements, were measured and compared to the theoretical predictions of the Huizenga-Vandenbosch method. The half-lives of short-lived activities were determined using a wide range time-to-pulse height converter and a multi-channel analyzer

  8. National comparison on volume sample activity measurement methods

    International Nuclear Information System (INIS)

    Sahagia, M.; Grigorescu, E.L.; Popescu, C.; Razdolescu, C.

    1992-01-01

    A national comparison on volume sample activity measurements methods may be regarded as a step toward accomplishing the traceability of the environmental and food chain activity measurements to national standards. For this purpose, the Radionuclide Metrology Laboratory has distributed 137 Cs and 134 Cs water-equivalent solid standard sources to 24 laboratories having responsibilities in this matter. Every laboratory has to measure the activity of the received source(s) by using its own standards, equipment and methods and report the obtained results to the organizer. The 'measured activities' will be compared with the 'true activities'. A final report will be issued, which plans to evaluate the national level of precision of such measurements and give some suggestions for improvement. (Author)

  9. Development of alarm handling methods for boiling water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Yukiharu, Ohga; Hiroshi, Seki; Setsuo, Arita [Power and Industrial Systems R and D Div., Hitachi, Ltd., Hitachi, Ibaraki (Japan)

    1997-09-01

    A method was developed to select important alarms in two steps: first, selection is based on the physical relationship between the alarms, and second, selection is according to the initial event. An approach combining a neural network and knowledge processing was proposed to identify the event rapidly. A prototype system was evaluated in the Kashiwazaki/Kariwa-4 Nuclear Power Plant during the startup test. The evaluation test confirmed that about 30% of the alarms are selected from among the many activated alarms. The second method, dealing with presentation, supports operators in their selection and confirmation of the required information for plant operation. The method selects and offers plant information in response to plant status changes and operators` demands. The selection procedure is based on the knowledge and data as structured by the plant functional structure; i.e. a means-ends abstraction hierarchy model. A prototype system was evaluated using a BWR simulator. The results showed that appropriate information items are automatically selected according to plant status changes and information on generated alarms is presented to operators together with the related trend graph and system diagram. Answers are generated in reply to the operators` demands and operators can confirm the generated alarms on each plant function, such as systems and components. 8 refs, 10 figs, 2 tabs.

  10. Development of alarm handling methods for boiling water reactors

    International Nuclear Information System (INIS)

    Ohga Yukiharu; Seki Hiroshi; Arita Setsuo

    1997-01-01

    A method was developed to select important alarms in two steps: first, selection is based on the physical relationship between the alarms, and second, selection is according to the initial event. An approach combining a neural network and knowledge processing was proposed to identify the event rapidly. A prototype system was evaluated in the Kashiwazaki/Kariwa-4 Nuclear Power Plant during the startup test. The evaluation test confirmed that about 30% of the alarms are selected from among the many activated alarms. The second method, dealing with presentation, supports operators in their selection and confirmation of the required information for plant operation. The method selects and offers plant information in response to plant status changes and operators' demands. The selection procedure is based on the knowledge and data as structured by the plant functional structure; i.e. a means-ends abstraction hierarchy model. A prototype system was evaluated using a BWR simulator. The results showed that appropriate information items are automatically selected according to plant status changes and information on generated alarms is presented to operators together with the related trend graph and system diagram. Answers are generated in reply to the operators' demands and operators can confirm the generated alarms on each plant function, such as systems and components. 8 refs, 10 figs, 2 tabs

  11. Advanced Aqueous Phase Catalyst Development using Combinatorial Methods, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Combinatorial methods are proposed to develop advanced Aqueous Oxidation Catalysts (AOCs) with the capability to mineralize organic contaminants present in effluents...

  12. Emergency medicine clerkship curriculum in a high-income developing country: methods for development and application.

    Science.gov (United States)

    Cevik, Arif Alper; Cakal, Elif Dilek; Abu-Zidan, Fikri M

    2018-06-07

    The published recommendations for international emergency medicine curricula cover the content, but exclude teaching and learning methods, assessment, and evaluation. We aim to provide an overview on available emergency medicine clerkship curricula and report the development and application experience of our own curriculum. Our curriculum is an outcome-based education, enriched by e-learning and various up-to-date pedagogic principles. Teaching and learning methods, assessment, and evaluation are described. The theory behind our practice in the light of recent literature is discussed aiming to help other colleagues from developing countries to have a clear map for developing and tailoring their own curricula depending on their needs. The details of our emergency medicine clerkship will serve as an example for developing and developed countries having immature undergraduate emergency medicine clerkship curricula. However, these recommendations will differ in various settings depending on available resources. The main concept of curriculum development is to create a curriculum having learning outcomes and content relevant to the local context, and then align the teaching and learning activities, assessments, and evaluations to be in harmony. This may assure favorable educational outcome even in resource limited settings.

  13. Recent UK research and the development of high temperature design methods

    International Nuclear Information System (INIS)

    Rose, R.T.; Tomkins, B.; Townley, C.H.A.

    1987-01-01

    The paper outlines recent research and development activities on high temperature design methods and criteria for high temperature components as utilized by liquid metal cooled fast breeder reactors. (orig.)

  14. The development of EUROFER reduced activation steel

    Energy Technology Data Exchange (ETDEWEB)

    Schaaf, B. van der E-mail: vanderschaaf@nrg-nl.com; Tavassoli, F.; Fazio, C.; Rigal, E.; Diegele, E.; Lindau, R.; LeMarois, G

    2003-09-01

    Ferritic martensitic steels show limited swelling and susceptibility to helium effects and can be made with low activation chemical compositions. These properties make them the reference steel for the development of breeding blankets in fusion power plants. EUROFER97 is the European implementation of such a steel, where experience gained from an IEA co-operation with Japan and the US is also implemented. Results obtained so far show that EUROFER steel has attractive mechanical properties even after long ageing times. Compatibility tests in water and PbLi17 are in progress. Oxidised aluminium is the most effective protective layer in PbLi17. The displacement damage and helium formation strongly influence the hydrogen transport in the steel. Present experiments should be backed by tests in a more fusion relevant environment, e.g. IFMIF. The 2.5 dpa neutron irradiations at low temperatures result in a higher DBTT. High dose irradiations, up to 80 dpa, are underway. The early results of ODS grades with EUROFER steel composition show potential of these grades for increasing the operating temperature with 100-150 K.

  15. Accelerated molecular dynamics methods: introduction and recent developments

    International Nuclear Information System (INIS)

    Uberuaga, Blas Pedro; Voter, Arthur F.; Perez, Danny; Shim, Y.; Amar, J.G.

    2009-01-01

    A long-standing limitation in the use of molecular dynamics (MD) simulation is that it can only be applied directly to processes that take place on very short timescales: nanoseconds if empirical potentials are employed, or picoseconds if we rely on electronic structure methods. Many processes of interest in chemistry, biochemistry, and materials science require study over microseconds and beyond, due either to the natural timescale for the evolution or to the duration of the experiment of interest. Ignoring the case of liquids xxx, the dynamics on these time scales is typically characterized by infrequent-event transitions, from state to state, usually involving an energy barrier. There is a long and venerable tradition in chemistry of using transition state theory (TST) (10, 19, 23) to directly compute rate constants for these kinds of activated processes. If needed dynamical corrections to the TST rate, and even quantum corrections, can be computed to achieve an accuracy suitable for the problem at hand. These rate constants then allow them to understand the system behavior on longer time scales than we can directly reach with MD. For complex systems with many reaction paths, the TST rates can be fed into a stochastic simulation procedure such as kinetic Monte Carlo xxx, and a direct simulation of the advance of the system through its possible states can be obtained in a probabilistically exact way. A problem that has become more evident in recent years, however, is that for many systems of interest there is a complexity that makes it difficult, if not impossible, to determine all the relevant reaction paths to which TST should be applied. This is a serious issue, as omitted transition pathways can have uncontrollable consequences on the simulated long-time kinetics. Over the last decade or so, we have been developing a new class of methods for treating the long-time dynamics in these complex, infrequent-event systems. Rather than trying to guess in advance what

  16. Accelerated molecular dynamics methods: introduction and recent developments

    Energy Technology Data Exchange (ETDEWEB)

    Uberuaga, Blas Pedro [Los Alamos National Laboratory; Voter, Arthur F [Los Alamos National Laboratory; Perez, Danny [Los Alamos National Laboratory; Shim, Y [UNIV OF TOLEDO; Amar, J G [UNIV OF TOLEDO

    2009-01-01

    A long-standing limitation in the use of molecular dynamics (MD) simulation is that it can only be applied directly to processes that take place on very short timescales: nanoseconds if empirical potentials are employed, or picoseconds if we rely on electronic structure methods. Many processes of interest in chemistry, biochemistry, and materials science require study over microseconds and beyond, due either to the natural timescale for the evolution or to the duration of the experiment of interest. Ignoring the case of liquids xxx, the dynamics on these time scales is typically characterized by infrequent-event transitions, from state to state, usually involving an energy barrier. There is a long and venerable tradition in chemistry of using transition state theory (TST) [10, 19, 23] to directly compute rate constants for these kinds of activated processes. If needed dynamical corrections to the TST rate, and even quantum corrections, can be computed to achieve an accuracy suitable for the problem at hand. These rate constants then allow them to understand the system behavior on longer time scales than we can directly reach with MD. For complex systems with many reaction paths, the TST rates can be fed into a stochastic simulation procedure such as kinetic Monte Carlo xxx, and a direct simulation of the advance of the system through its possible states can be obtained in a probabilistically exact way. A problem that has become more evident in recent years, however, is that for many systems of interest there is a complexity that makes it difficult, if not impossible, to determine all the relevant reaction paths to which TST should be applied. This is a serious issue, as omitted transition pathways can have uncontrollable consequences on the simulated long-time kinetics. Over the last decade or so, we have been developing a new class of methods for treating the long-time dynamics in these complex, infrequent-event systems. Rather than trying to guess in advance what

  17. DANTE, Activation Analysis Neutron Spectra Unfolding by Covariance Matrix Method

    International Nuclear Information System (INIS)

    Petilli, M.

    1981-01-01

    1 - Description of problem or function: The program evaluates activation measurements of reactor neutron spectra and unfolds the results for dosimetry purposes. Different evaluation options are foreseen: absolute or relative fluxes and different iteration algorithms. 2 - Method of solution: A least-square fit method is used. A correlation between available data and their uncertainties has been introduced by means of flux and activity variance-covariance matrices. Cross sections are assumed to be constant, i.e. with variance-covariance matrix equal to zero. The Lagrange multipliers method has been used for calculating the solution. 3 - Restrictions on the complexity of the problem: 9 activation experiments can be analyzed. 75 energy groups are accepted

  18. Research on LQR optimal control method of active engine mount

    Science.gov (United States)

    Huan, Xie; Yu, Duan

    2018-04-01

    In this paper, the LQR control method is applied to the active mount of the engine, and a six-cylinder engine excitation model is established. Through the joint simulation of AMESim and MATLAB, the vibration isolation performance of the active mount system and the passive mount system is analyzed. Excited by the multi-engine operation, the simulation results of the vertical displacement, acceleration and dynamic deflection of the vehicle body show that the vibration isolation capability of the active mount system is superior to that of the passive mount system. It shows that compared with the passive mount, LQR active mount can greatly improve the vibration isolation performance, which proves the feasibility and effectiveness of the LQR control method.

  19. ANDRA - 2012 activity and sustainable development report

    International Nuclear Information System (INIS)

    Renauld, Valerie; Levert, Anne-Sophie; Muzerelle, Sophie; Cassoli, Emmanuel

    2013-07-01

    After a brief presentation of the main events during 2012, a recall of the ANDRA's mission (national inventory of radioactive materials and wastes), and a brief presentation of staffing data, this report presents and comments the activities of the ANDRA in the industrial domain (the Cigeo project for deep geological disposal of radioactive wastes, activities of the Aube centres and of the Manche storage centre, perspectives for low-activity long-life wastes, decontamination of polluted sites), in the scientific field (European projects, support to education and training, participation to a colloquium on clays, activities in the field of numerical simulation, activities of the 'Observatoire de l'Environnement'). The next part address the international activities, local commitments (in relationship with the different storage and industrial centres, or in the field of education and training), and activities related to communication and information

  20. Generating and testing methods for consumer-oriented product development

    International Nuclear Information System (INIS)

    2001-10-01

    In order to obtain a good insight into various design methods that can be used by product developers to enable them to develop and test useful domotics products (domotics: intelligent systems for the home), an inventory has been made of the methods used in the Netherlands. The inventory is directed at two categories of methods: (1) Methods of getting better acquainted with the user and/or the problem, and of generating novel solutions: generative methods; and (2) Methods of assessing solutions (through various phases of the designing process): testing methods. The first category of methods concentrates on the designing process. In other words: how can the designer realise as much as possible of the workability of (domotics) products during the designing process? The second category aims at testing a design (in whatever shape: drawing, prototype, functional computer animation, etc.) through its users. These are methods of assessing a design at various stages of the designing process [nl

  1. Development and Testing of the Observational System for Recording Physical Activity in Children: Elementary School

    Science.gov (United States)

    McIver, Kerry L.; Brown, William H.; Pfeiffer, Karin A.; Dowda, Marsha; Pate, Russell R.

    2016-01-01

    Purpose: This study describes the development and pilot testing of the Observational System for Recording Physical Activity-Elementary School (OSRAC-E) Version. Method: This system was developed to observe and document the levels and types of physical activity and physical and social contexts of physical activity in elementary school students…

  2. Development of Early Warning Methods for Electric Power Systems

    DEFF Research Database (Denmark)

    Jóhannsson, Hjörtur

    This thesis concerns the development of methods that can provide, in realtime, an early warning for an emerging blackout in electric power systems. The blackout in E-Denmark and S-Sweden on September 23, 2003 is the main motivation for the method development. The blackout was caused by occurrence...

  3. How Qualitative Methods Can be Used to Inform Model Development.

    Science.gov (United States)

    Husbands, Samantha; Jowett, Susan; Barton, Pelham; Coast, Joanna

    2017-06-01

    Decision-analytic models play a key role in informing healthcare resource allocation decisions. However, there are ongoing concerns with the credibility of models. Modelling methods guidance can encourage good practice within model development, but its value is dependent on its ability to address the areas that modellers find most challenging. Further, it is important that modelling methods and related guidance are continually updated in light of any new approaches that could potentially enhance model credibility. The objective of this article was to highlight the ways in which qualitative methods have been used and recommended to inform decision-analytic model development and enhance modelling practices. With reference to the literature, the article discusses two key ways in which qualitative methods can be, and have been, applied. The first approach involves using qualitative methods to understand and inform general and future processes of model development, and the second, using qualitative techniques to directly inform the development of individual models. The literature suggests that qualitative methods can improve the validity and credibility of modelling processes by providing a means to understand existing modelling approaches that identifies where problems are occurring and further guidance is needed. It can also be applied within model development to facilitate the input of experts to structural development. We recommend that current and future model development would benefit from the greater integration of qualitative methods, specifically by studying 'real' modelling processes, and by developing recommendations around how qualitative methods can be adopted within everyday modelling practice.

  4. Development and Validation of Analytical Method for Losartan ...

    African Journals Online (AJOL)

    Development and Validation of Analytical Method for Losartan-Copper Complex Using UV-Vis Spectrophotometry. ... Tropical Journal of Pharmaceutical Research ... Purpose: To develop a new spectrophotometric method for the analysis of losartan potassium in pharmaceutical formulations by making its complex with ...

  5. Developing a reliable signal wire attachment method for rail.

    Science.gov (United States)

    2014-11-01

    The goal of this project was to develop a better attachment method for rail signal wires to improve the reliability of signaling : systems. EWI conducted basic research into the failure mode of current attachment methods and developed and tested a ne...

  6. A colorimetric method to quantify endo-polygalacturonase activity.

    Science.gov (United States)

    Torres, Sebastián; Sayago, Jorge E; Ordoñez, Roxana M; Isla, María Inés

    2011-02-08

    We report a new colorimetric assay to quantify endo-polygalacturonase activity, which hydrolyzes polygalacturonic acid to produce smaller chains of galacturonate. Some of the reported polygalacturonase assays measure the activity by detecting the appearance of reducing ends such as the Somogyi-Nelson method. As a result of being general towards reducing groups, the Somogyi-Nelson method is not appropriate when studying polygalacturonase and polygalacturonase inhibitors in plant crude extracts, which often have a strong reducing power. Ruthenium Red is an inorganic dye that binds polygalacturonic acid and causes its precipitation. In the presence of polygalacturonase, polygalacturonic acid is hydrolyzed bringing about a corresponding gain in soluble Ruthenium Red. The described assay utilizes Ruthenium Red as the detection reagent which has been used previously in plate-based assays but not in liquid medium reactions. The new method measures the disappearance of the substrate polygalacturonic acid and is compared to the Somogyi-Nelson assay. The experimental results using lemon peel, a fern fronds and castor leaf crude extracts demonstrate that the new method provides a way to the quickly screening of polygalacturonase activity and polygalacturonase inhibitors in plant crude extracts containing high amounts of reducing power. On the other hand, the Ruthenium Red assay is not able to determine the activity of an exo-polygalacturonase as initial velocity and thus would allow the differentiation between endo- and exo-polygalacturonase activities. Copyright © 2010 Elsevier Inc. All rights reserved.

  7. Implementation of Active Learning Method in Unit Operations II Subject

    OpenAIRE

    Ma'mun, Sholeh

    2018-01-01

    ABSTRACT: Active Learning Method which requires students to take an active role in the process of learning in the classroom has been applied in Department of Chemical Engineering, Faculty of Industrial Technology, Islamic University of Indonesia for Unit Operations II subject in the Even Semester of Academic Year 2015/2016. The purpose of implementation of the learning method is to assist students in achieving competencies associated with the Unit Operations II subject and to help in creating...

  8. Infusing Active Learning into the Research Methods Unit

    Science.gov (United States)

    Bluestone, Cheryl

    2007-01-01

    The research methods unit of survey psychology classes introduces important concepts of scientific reasoning and fluency, making it an ideal course in which to deliver enhanced curricula. To increase interest and engagement, the author developed an expanded research methods and statistics module to give students the opportunity to explore…

  9. Development of analysis methods for seismically isolated nuclear structures

    International Nuclear Information System (INIS)

    Yoo, Bong; Lee, Jae-Han; Koo, Gyeng-Hoi

    2002-01-01

    KAERI's contributions to the project entitled Development of Analysis Methods for Seismically Isolated Nuclear Structures under IAEA CRP of the intercomparison of analysis methods for predicting the behaviour of seismically isolated nuclear structures during 1996-1999 in effort to develop the numerical analysis methods and to compare the analysis results with the benchmark test results of seismic isolation bearings and isolated nuclear structures provided by participating countries are briefly described. Certain progress in the analysis procedures for isolation bearings and isolated nuclear structures has been made throughout the IAEA CRPs and the analysis methods developed can be improved for future nuclear facility applications. (author)

  10. The thin layer activation method and its applications in industry

    International Nuclear Information System (INIS)

    1997-01-01

    The thin layer activation (TLA) method is one of the most effective and precise methods for the measurement and monitoring of corrosion (erosion) and wear in industry and is used for on-line remote measurement of wear and corrosion rate of central parts in machines or processing vessels under real operating conditions. This document is a comprehensive manual on TLA method in its applications for monitoring wear and corrosion in industry. It describes the theory and presents case studies on TLA method applications in industry. In addition, in annexes are given tables of nuclear data relating to TLA (decay characteristics, depth distribution of reaction products, activation data for charged-particle nuclear reactions), references from INIS database on TLA and a detailed production of the application of TLA for wear measurement of superhard turning tools

  11. Activity measurements of {sup 55}Fe by two different methods

    Energy Technology Data Exchange (ETDEWEB)

    Cruz, P.A.L. da; Iwahara, A.; Silva, C.J. da; Poledna, R.; Loureiro, J.S.; Silva, M.A.L. da, E-mail: palcruz@ird.gov.br [Instituto de Radioproteção e Dosimetria (LNMRI/IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. Nacional de Metrologia das Radiações Ionizantes; Ruzzarin, Anelise [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2017-07-01

    A calibrated germanium detector and CIEMAT/NIST liquid scintillation method were used in the standardization of solution of {sup 55}Fe coming from a key-comparison BIPM. Commercial HISAFE'3 cocktails were used in source preparation for activity measurements in CIEMAT/NIST method. Measurements were performed in Liquid Scintillation Counter. In the germanium counting method standard point sources were prepared for obtaining atomic number versus efficiency curve of the detector in order to obtain the efficiency of 5.9 keV KX-ray of {sup 55}Fe by interpolation. The activity concentrations obtained were 508.2 ± 3.56 and 510.0 ± 16.20 kBq/g, respectively for CIEMAT/NIST and germanium methods. (author)

  12. Force Feedback Control Method of Active Tuned Mass Damper

    Directory of Open Access Journals (Sweden)

    Xiuli Wang

    2017-01-01

    Full Text Available Active tuned mass dampers as vibration-control devices are widely used in many fields for their good stability and effectiveness. To improve the performance of such dampers, a control method based on force feedback is proposed. The method offers several advantages such as high-precision control and low-performance requirements for the actuator, as well as not needing additional compensators. The force feedback control strategy was designed based on direct-velocity feedback. The effectiveness of the method was verified in a single-degree-of-freedom system, and factors such as damping effect, required active force, actuator stroke, and power consumption of the damper were analyzed. Finally, a simulation study was performed by configuring a main complex elastic-vibration-damping system. The results show that the method provides effective control over modal resonances of multiple orders of the system and improves its dynamics performance.

  13. The thin layer activation method and its applications in industry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The thin layer activation (TLA) method is one of the most effective and precise methods for the measurement and monitoring of corrosion (erosion) and wear in industry and is used for on-line remote measurement of wear and corrosion rate of central parts in machines or processing vessels under real operating conditions. This document is a comprehensive manual on TLA method in its applications for monitoring wear and corrosion in industry. It describes the theory and presents case studies on TLA method applications in industry. In addition, in annexes are given tables of nuclear data relating to TLA (decay characteristics, depth distribution of reaction products, activation data for charged-particle nuclear reactions), references from INIS database on TLA and a detailed production of the application of TLA for wear measurement of superhard turning tools.

  14. Method Development and Monitoring of Cyanotoxins in Water

    Science.gov (United States)

    This presentation describes method development of two ambient water LC/MS/MS methods for microcystins, cylindrospermopsin and anatoxin-a. Ruggedness of the methods will be demonstrated by evaluation of quality control samples derived from various water bodies across the country.

  15. Development of a Research Methods and Statistics Concept Inventory

    Science.gov (United States)

    Veilleux, Jennifer C.; Chapman, Kate M.

    2017-01-01

    Research methods and statistics are core courses in the undergraduate psychology major. To assess learning outcomes, it would be useful to have a measure that assesses research methods and statistical literacy beyond course grades. In two studies, we developed and provided initial validation results for a research methods and statistical knowledge…

  16. Development of semi-active hydraulic damper as active interaction ...

    Indian Academy of Sciences (India)

    Semi-auto controller; displacement semi-active hydraulic damper; ... 2000), and Magnetorheological Damper (Dyke et al 1998) were widely discussed or used. ... driving force provided by electrical motor causes the subordinate structure to ...

  17. 应用RNA干扰技术创造低脂肪氧化酶活性大豆新种质%Development of Novel Soybean Germplasms with Low Activity of Lipoxygenases by RNAi Method

    Institute of Scientific and Technical Information of China (English)

    马建; 张君; 曲静; 王云鹏; 魏益凡; 王丕武

    2009-01-01

    [目的]通过RNA干扰技术抑制大豆籽粒中脂肪氧化酶基因表达,改良大豆品质,创造优良大豆新种质,探索大豆品质育种新途径.[方法]采用RT-PCR技术克隆大豆籽粒脂肪氧化酶基因(Lx1、Lx2、Lx3)核心保守序列357 bp片段,通过重组PeR构建大豆脂肪氧化酶基因RNA干扰表达载体,利用花粉管通道法转化大豆品种吉农18.[结果]获得了12个转基因株系,其中10个株系发生明显变化,SDS-PAGE电泳和脂肪氧化酶活性测定表明转基因植株籽粒中脂肪氧化酶活性明显降低,平均减低64.2%;经近红外谷物分析仪测定,转基因植株脂肪含量平均提高0.8%~1.5%,总蛋白含量降低1.2%~3.0%;RT-PCR结果表明转基因株系中脂肪氧化酶mRNA积累受到明显抑制.转基因植株2代及3代检测结果表明,转基因植株脂肪氧化酶活性均明显降低,脂肪含量均有所提高.[结论]应用RNA干扰技术可有效的抑制大豆籽粒中脂肪氧化酶基因表达,降低脂肪氧化酶活性,提高大豆油份含量,改良大豆品质,创造优良大豆种质.%[Objective] The objective of this study was try to find a new avenue of breeding technique in soybean to improve the quality of soybeans and create new superordinary germplasm resource of soybeans by RNAi, which prohibits the gene expression of iipoxygenase in soybean seed. [Method] The consensus sequence of lipoxygenase gene (Lx1, Lx2, Lx3) in soybean seeds was cloned by RT-PCR, the length of the sequence was 357 bp. An RNAi expression vector of soybean lipoxygenase gene was reconstructed by recombinant PCR, and transformed the vector in soybean (Jinong 18) by pollen tube pathway. [Result] Twelve transgenic strains were obtained and 10 of which demonstrated significant differences. SDS-PAGE and activity of iipoxygenase demonstrated that the iipoxygenase activity of transgenic soybeans decreased significantly, the degree of decreasing was 64.2% on average. The near-infrared analyses

  18. Effects of preparation method and active metal content on of Ni/kieselguhr catalyst activity

    International Nuclear Information System (INIS)

    Galuh Widiyarti; Wuryaningsih Sri Rahayu

    2010-01-01

    The preparation and the active metal content influence the activity of catalyst. Study has been conducted to see the activity of Ni/kieselguhr based on preparation method and Nickel (Ni) contents in the catalyst in the laboratory scale. The Ni/kieselguhr catalyst were prepared by impregnation and precipitation methods, with Ni active contents of 10, 20, and 30 % by weight. The catalysts characterization was analyzed using X-Ray Diffraction (XRD). Catalysts activities were analyzed based on decreasing of iodine number from hydrogenation of crude palm oil for 2 hours. The activity tests results show that precipitation catalysts are more active than impregnation catalysts. The decreasing in iodine number of fatty acid after 2 hours of hydrogenation process using precipitation catalysts and impregnation catalysts are 51.53 and 21.85 %, respectively. In addition, the catalysts are more active with increasing Ni contents. (author)

  19. Evaluation of harmonic detection methods for active power filter applications

    DEFF Research Database (Denmark)

    Asiminoaei, Lucian; Blaabjerg, Frede; Hansen, Steffan

    2005-01-01

    In the attempt to minimize the harmonic disturbances created by the non-linear loads the choice of the active power filters comes out to improve the filtering efficiency and to solve many issues existing with classical passive filters. One of the key points for a proper implementation of an active...... theories. Then, the work here proposes a simulation setup that decouples the harmonic reference generator from the active filter model and its controller. In this way the selected methods can be equally analyzed and compared with respect to their performance, which helps anticipating possible...

  20. Development of a new method to identify aminoacylated RNA

    Directory of Open Access Journals (Sweden)

    Wang Ji

    2014-02-01

    Full Text Available A RT-PCR method is developed to isolate RNA aminoacylated on their 3’ end from large pools of RNA. The method is being applied in two separate projects. We are interested in isolating a new class of ribozymes that could successively catalyze the two chemical reactions leading to their own 3’ aminoacylation (ATP activation of an amino acid followed by 3' esterification of the RNA. The catalysis of each of the two reactions has independently been demonstrated for some RNA isolated with the SELEX methodology [1-2]. However, the coupling of both reactions on a same molecule has not been achieved yet. The identification of these still hypothetical ribozymes may help understand how the former translation system started in the absence of the aminoacyltRNA Synthetase, which catalyzes the above two reactions on tRNA in modern cells. In another project, we would like to identify the whole repertoire of aminoacylated RNA (the “aminoacylome” in cells. There are strong indications that other RNA besides tRNA and tmRNA may be aminoacylated for biological purposes [3-4].

  1. Psychological preconditions of game activity development in the early childhood

    OpenAIRE

    Valeriya Spitsyna; Ekaterina Saraykina

    2013-01-01

    The article is devoted for detection the psychological preconditions of game activity development at early age and interrelation of game formation with the development of subject actions, informative activity and procedural game.

  2. INFRASTRUCTURE ACTIVATION OF INNOVATIVE DEVELOPMENT OF UKRAINIAN AGRARIAN SECTOR

    Directory of Open Access Journals (Sweden)

    Svitlana Syrtseva

    2017-12-01

    , organized at the agricultural universities that provide links with rural youth, agricultural enterprises, and scientific organizations. Proved, that two groups of methods – direct and indirect – should represent the most important directions of the state policy on the development of venture investments of innovative development of the agricultural sector. Value/originality. The formation and functioning of the optimal system of institutes of innovation infrastructure with the help of appropriate tools and methods will promote the active introduction of innovations in the agrarian sector of the economy and bring it to a qualitatively new level of development.

  3. Physical activity and pediatric multiple sclerosis: Developing a research agenda.

    Science.gov (United States)

    Yeh, E Ann; Kinnett-Hopkins, Dominique; Grover, Stephanie A; Motl, Robert W

    2015-11-01

    Three-quarters of children with multiple sclerosis (MS) experience fatigue or depression, and progressive neurocognitive decline may be seen as early as two years after MS diagnosis. Furthermore, a higher magnetic resonance imaging disease burden is seen in pediatric-onset MS compared with adult-onset MS. To date, limited knowledge exists regarding behavioral methods for managing symptoms and disease progression in pediatric MS. To that end, this paper builds an evidence-based argument for the possible symptomatic and disease-modifying effects of exercise and physical activity in pediatric MS. This will be accomplished through: (a) a review of pediatric MS and its consequences; (b) a brief overview of physical activity and its consequences in children and adults with MS; and (c) a selective review of research on the neurological benefits of physical activity in pediatric populations. This topical review concludes with a list of 10 questions to guide future research on physical activity and pediatric MS. The objective of this paper is the provision of a research interest, focus and agenda involving pediatric MS and its lifelong management though exercise and physical activity behavior. Such an agenda is critical as the effects and maintenance of physical activity and exercise track across the lifespan, particularly when developed in the early stages of life. © The Author(s), 2015.

  4. Valid methods: the quality assurance of test method development, validation, approval, and transfer for veterinary testing laboratories.

    Science.gov (United States)

    Wiegers, Ann L

    2003-07-01

    Third-party accreditation is a valuable tool to demonstrate a laboratory's competence to conduct testing. Accreditation, internationally and in the United States, has been discussed previously. However, accreditation is only I part of establishing data credibility. A validated test method is the first component of a valid measurement system. Validation is defined as confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled. The international and national standard ISO/IEC 17025 recognizes the importance of validated methods and requires that laboratory-developed methods or methods adopted by the laboratory be appropriate for the intended use. Validated methods are therefore required and their use agreed to by the client (i.e., end users of the test results such as veterinarians, animal health programs, and owners). ISO/IEC 17025 also requires that the introduction of methods developed by the laboratory for its own use be a planned activity conducted by qualified personnel with adequate resources. This article discusses considerations and recommendations for the conduct of veterinary diagnostic test method development, validation, evaluation, approval, and transfer to the user laboratory in the ISO/IEC 17025 environment. These recommendations are based on those of nationally and internationally accepted standards and guidelines, as well as those of reputable and experienced technical bodies. They are also based on the author's experience in the evaluation of method development and transfer projects, validation data, and the implementation of quality management systems in the area of method development.

  5. Developments in the active packaging of foods

    NARCIS (Netherlands)

    Vermeiren, L.; Devlieghere, F.; Beest, M. van; Kruijf, N. de; Debevere, J.

    1999-01-01

    Active packaging is one of the innovative food packaging concepts that has been introduced as a response to the continuous changes in current consumer demands and market trends. Major active packaging techniques are concerned with substances that absorb oxygen, ethylene, moisture, carbon dioxide,

  6. Low-Threshold Active Teaching Methods for Mathematic Instruction

    Science.gov (United States)

    Marotta, Sebastian M.; Hargis, Jace

    2011-01-01

    In this article, we present a large list of low-threshold active teaching methods categorized so the instructor can efficiently access and target the deployment of conceptually based lessons. The categories include teaching strategies for lecture on large and small class sizes; student action individually, in pairs, and groups; games; interaction…

  7. A method to determine validity and reliability of activity sensors

    NARCIS (Netherlands)

    Boerema, Simone Theresa; Hermens, Hermanus J.

    2013-01-01

    METHOD Four sensors were securely fastened to a mechanical oscillator (Vibration Exciter, type 4809, Brüel & Kjær) and moved at various frequencies (6.67Hz; 13.45Hz; 19.88Hz) within the range of human physical activity. For each of the three sensor axes, the sensors were simultaneously moved for

  8. Phosphorus analysis in milk samples by neutron activation analysis method

    International Nuclear Information System (INIS)

    Oliveira, R.M. de; Cunha, I.I.L.

    1991-01-01

    The determination of phosphorus in milk samples by instrumental thermal neutron activation analysis is described. The procedure involves a short irradiation in a nuclear reactor and measurement of the beta radiation emitted by phosphorus - 32 after a suitable decay period. The sources of error were studied and the established method was applied to standard reference materials of known phosphorus content. (author)

  9. Scaffolding Assignments and Activities for Undergraduate Research Methods

    Science.gov (United States)

    Fisher, Sarah; Justwan, Florian

    2018-01-01

    This article details assignments and lessons created for and tested in research methods courses at two different universities, a large state school and a small liberal arts college. Each assignment or activity utilized scaffolding. Students were asked to push beyond their comfort zone while utilizing concrete and/or creative examples,…

  10. An active vibration control method of bridge structures by the ...

    African Journals Online (AJOL)

    The 'Linearization of Feedback Gain Matrix' (LFGM) method proposed by the author to achieve this objective is obtained by activating some useful components of the Riccati matrix while others are strongly attenuated according to the expected output-results and requirements of control mechanism. The present algorithm is ...

  11. Development for low-activation concrete design reducing radioactive waste

    International Nuclear Information System (INIS)

    Kimura, Ken-ichi; Kinno, Masaharu; Hasegawa, Akira

    2008-01-01

    Full text: Concrete is very valuable and inexpensive material, however it can be changed to be expensive and hard to deal with in use of a nuclear plant after long operation. One of the counter plans for the above is to use low-activation concrete instead of the ordinary concrete, that will reduce radioactive waste and could be even below clearance level in decommissioning and that is very useful in term of life cycle cost. Radioactive analysis showed that Co and Eu were the major target elements which decide the radioactivity level of reinforced concrete in decommissioning stage, and a several material were selected as a low-activation raw material from wide survey of raw materials for concrete (typically aggregates and cements). With the canditate of raw materials, several low-activation concrete were proposed for various portion of light water reactor plant, which reduction ratio were 1/10 to 1/30 which were mainly consist of limestone and low heat cement or white cement, and 1/100 to 1/300 which were mainly consist of alumina aggregate or quartz and high almina cement, comparing to the ordinary concrete in ΣDi/Ci unit, where 'Di' indicates concentration of each residual radioisotope, Ci defined by IAEA as a clearance level, and suffition of 'i' indicates each radioisotope. National funded project for development of low-activation design method for reduction of radioactive waste below clearance level were started from 2005 with aiming (1) development of a database on the content of target elements, which transform radioactive nuclides, in raw materials of reinforced concrete, (2) development of calculation tools for estimation of residual radioactivity of plant components, and (3) development of low-activation materials for concrete such as cements and reinforcing steel bars for structural components. For the optimized design for applying low-activation concrete to the reactor portion, effective evaluation of neutron spectrum in the certain portion including

  12. Studies on the instrumental neutron activation analysis by cadmium ratio method and pair comparator method

    Energy Technology Data Exchange (ETDEWEB)

    Chao, H E; Lu, W D; Wu, S C

    1977-12-01

    The cadmium ratio method and pair comparator method provide a solution for the effects on the effective activation factors resulting from the variation of neutron spectrum at different irradiation positions as usually encountered in the single comparator method. The relations between the activation factors and neutron spectrum in terms of cadmium ratio of the comparator Au or of the activation factor of Co-Au pair for the elements, Sc, Cr, Mn, Co, La, Ce, Sm, and Th have been determined. The activation factors of the elements at any irradiation position can then be obtained from the cadmium ratio of the comparator and/or the activation factor of the comparator pair. The relations determined should be able to apply to different reactors and/or different positions of a reactor. It is shown that, for the isotopes /sup 46/Sc, /sup 51/Cr, /sup 56/Mn, /sup 60/Co, /sup 140/La, /sup 141/Ce, /sup 153/Sm and /sup 233/Pa, the thermal neutron activation factors determined by these two methods were generally in agreement with theoretical values. Their I/sub 0//sigma/sub th/ values appeared to agree with literature values also. The methods were applied to determine the contents of elements Sc, Cr, Mn, La, Ce, Sm, and Th in U.S.G.S. Standard Rock G-2, and the results were also in agreement with literature values. The cadmium ratio method and pair comparator method improved the single comparator method, and they are more suitable to analysis for multi-elements of a large number of samples.

  13. Moments of movement: active learning and practice development.

    Science.gov (United States)

    Dewing, Jan

    2010-01-01

    As our understanding of practice development becomes more sophisticated, we enhance our understanding of how the facilitation of learning in and from practice, can be more effectively achieved. This paper outlines an approach for enabling and maximizing learning within practice development known as 'Active Learning'. It considers how, given establishing a learning culture is a prerequisite for the sustainability of PD within organisations, practice developers can do more to maximize learning for practitioners and other stakeholders. Active Learning requires that more attention be given by organisations committed to PD, at a corporate and strategic level for how learning strategies are developed in the workplace. Specifically, a move away from a heavy reliance on training may be required. Practice development facilitators also need to review: how they organise and offer learning, so that learning strategies are consistent with the vision, aims and processes of PD; have skills in the planning, delivery and evaluation of learning as part of their role and influence others who provide more traditional methods of training and education.

  14. Technical activities report: Mechanical development studies

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.K.

    1952-05-01

    This monthly progress report covers activities in the following areas: pile control; shielding studies; process tube assembly; pile operating equipment; power recovery; pile piping; and test laboratory. A detailed discussion is given for each topic.

  15. Soybean phospholipase D activity determination. A comparison of two methods

    Directory of Open Access Journals (Sweden)

    Ré, E.

    2007-09-01

    Full Text Available Due to a discrepancy between previously published results, two methods to determine the soybean phospholipase D activity were evaluated. One method is based on the extraction of the enzyme from whole soybean flour, quantifying the enzyme activity on the extract. The other method quantifies the enzymatic activity on whole soybean flour without enzyme extraction. In the extraction-based-method, both the extraction time and the number of extractions were optimized. The highest phospholipase D activity values were obtained from the method without enzyme extraction. This method is less complex, requires less running-time and the conditions of the medium in which phospholipase D acts resemble the conditions found in the oil industrySe evaluaron dos métodos para determinar la actividad de la fosfolipasa D en soja debido a que existe discrepancia entre los resultados publicados. Un método se basa en la extracción de la enzima de la harina resultante de la molienda del grano de soja entero, cuantificando la actividad sobre el extracto. En el otro método, la cuantificación se realiza sobre la harina del grano entero molido, sin extraer la enzima. En el método de extracción se optimizaron tanto el tiempo como el número de extracciones. Los mayores valores de actividad de la fosfolipasa D se obtuvieron por el método sin extracción de la enzima. Este método es más simple, exige menos tiempo de ejecución y las condiciones del medio en que actúa la fosfolipasa D se asemejan a las condiciones encontradas en la industria aceitera.

  16. Game Design and Development as Mathematical Activities

    DEFF Research Database (Denmark)

    Jensen, Erik Ottar; Hanghøj, Thorkild; Misfeldt, Morten

    2016-01-01

    education which have mostly been tied to students making learning games involving specific mathematical content. Game design activities are reported to have a motivational pull for students. A challenge seems to be that the students are mostly motivated by the game design or the programming activities...... between user and goal through the computational artifacts being used. The framework serves as a lens for making sense of computer game design as a context for learning mathematics....

  17. Development and validation of NIR-chemometric methods for chemical and pharmaceutical characterization of meloxicam tablets.

    Science.gov (United States)

    Tomuta, Ioan; Iovanov, Rares; Bodoki, Ede; Vonica, Loredana

    2014-04-01

    Near-Infrared (NIR) spectroscopy is an important component of a Process Analytical Technology (PAT) toolbox and is a key technology for enabling the rapid analysis of pharmaceutical tablets. The aim of this research work was to develop and validate NIR-chemometric methods not only for the determination of active pharmaceutical ingredients content but also pharmaceutical properties (crushing strength, disintegration time) of meloxicam tablets. The development of the method for active content assay was performed on samples corresponding to 80%, 90%, 100%, 110% and 120% of meloxicam content and the development of the methods for pharmaceutical characterization was performed on samples prepared at seven different compression forces (ranging from 7 to 45 kN) using NIR transmission spectra of intact tablets and PLS as a regression method. The results show that the developed methods have good trueness, precision and accuracy and are appropriate for direct active content assay in tablets (ranging from 12 to 18 mg/tablet) and also for predicting crushing strength and disintegration time of intact meloxicam tablets. The comparative data show that the proposed methods are in good agreement with the reference methods currently used for the characterization of meloxicam tablets (HPLC-UV methods for the assay and European Pharmacopeia methods for determining the crushing strength and disintegration time). The results show the possibility to predict both chemical properties (active content) and physical/pharmaceutical properties (crushing strength and disintegration time) directly, without any sample preparation, from the same NIR transmission spectrum of meloxicam tablets.

  18. Tetrazolium Reduction-Malachite Green Method for Assessing the Viability of Filamentous Bacteria in Activated Sludge

    Science.gov (United States)

    Bitton, Gabriel; Koopman, Ben

    1982-01-01

    A method was developed to assess the activity of filamentous bacteria in activated sludge. It involves the incubation of activated sludge with 2(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl tetrazolium chloride followed by staining with malachite green. Both cells and 2(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl tetrazolium chloride-formazan crystals can be observed in prepared specimens by using bright-field microscopy. This procedure allowed us to distinguish between inactive and actively metabolizing filaments after chlorine application to control the bulking of activated sludge. Images PMID:16345999

  19. 24 CFR 570.203 - Special economic development activities.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Special economic development... § 570.203 Special economic development activities. A recipient may use CDBG funds for special economic... part of an economic development project. Guidelines for selecting activities to assist under this...

  20. Use Case Evaluation (UCE): A Method for Early Usability Evaluation in Software Development

    DEFF Research Database (Denmark)

    Stage, Jan; Høegh, Rune Thaarup; Hornbæk, K.

    2007-01-01

    t is often argued that usability problems should be identified as early as possible during software development, but many usability evaluation methods do not fit well in early development activities. We propose a method for usability evaluation of use cases, a widely used representation of design...... ideas produced early in software development processes. The method proceeds by systematic inspection of use cases with reference to a set of guidelines for usable design. To validate the method, four evaluators inspected a set of use cases for a health care application....

  1. Design Method of Active Disturbance Rejection Variable Structure Control System

    Directory of Open Access Journals (Sweden)

    Yun-jie Wu

    2015-01-01

    Full Text Available Based on lines cluster approaching theory and inspired by the traditional exponent reaching law method, a new control method, lines cluster approaching mode control (LCAMC method, is designed to improve the parameter simplicity and structure optimization of the control system. The design guidelines and mathematical proofs are also given. To further improve the tracking performance and the inhibition of the white noise, connect the active disturbance rejection control (ADRC method with the LCAMC method and create the extended state observer based lines cluster approaching mode control (ESO-LCAMC method. Taking traditional servo control system as example, two control schemes are constructed and two kinds of comparison are carried out. Computer simulation results show that LCAMC method, having better tracking performance than the traditional sliding mode control (SMC system, makes the servo system track command signal quickly and accurately in spite of the persistent equivalent disturbances and ESO-LCAMC method further reduces the tracking error and filters the white noise added on the system states. Simulation results verify the robust property and comprehensive performance of control schemes.

  2. Development of QSAR model for immunomodulatory activity of natural coumarinolignoids

    Directory of Open Access Journals (Sweden)

    Dharmendra K Yadav

    2010-07-01

    Full Text Available Dharmendra K Yadav, Abha Meena, Ankit Srivastava, D Chanda, Feroz Khan, SK ChattopadhyayMetabolic and Structural Biology Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, PO-CIMAP, IndiaAbstract: Immunomodulation is the process of alteration in immune response due to foreign intrusion of molecules inside the body. Along with the available drugs, a large number of herbal drugs are promoted in traditional Indian treatments, for their immunomodulating activity. Natural coumarinolignoids isolated from the seeds of Cleome viscose have been recognized as having hepatoprotective action and have recently been tested preclinically for their immunomodulatory activity affecting both cell-mediated and humoral immune response. To explore the immunomodulatory compound from derivatives of coumarinolignoids, a quantitative structure activity relationship (QSAR and molecular docking studies were performed. Theoretical results are in accord with the in vivo experimental data studied on Swiss albino mice. Immunostimulatory activity was predicted through QSAR model, developed by forward feed multiple linear regression method with leave-one-out approach. Relationship correlating measure of QSAR model was 99% (R2 = 0.99 and predictive accuracy was 96% (RCV2 = 0.96. QSAR studies indicate that dipole moment, steric energy, amide group count, lambda max (UV-visible, and molar refractivity correlates well with biological activity, while decrease in dipole moment, steric energy, and molar refractivity has negative correlation. Docking studies also showed strong binding affinity to immunomodulatory receptors.Keywords: coumarinolignoids, immunomodulation, docking, QSAR, regression model

  3. Development of a new disintegration method for orally disintegrating tablets.

    Science.gov (United States)

    Kakutani, Ryo; Muro, Hiroyuki; Makino, Tadashi

    2010-07-01

    Recently, the focus has been on the importance of assessing the oral disintegrative properties of orally disintegrating tablets (ODTs). In particular, in the development stages and the quality control field of ODT products, a physical assessment method which easily measures oral disintegrative properties is desired. For this reason, we developed a new disintegration test method (Kyoto-model disintegration method or KYO method), which is useful to predict the oral disintegrative properties of an ODT easily, and examined the availability of the method. In the KYO method, ODT samples were classified in terms of their water permeability, and a moderate water volume was decided. Subsequently, the disintegrative properties were assessed with the newly proposed method. For 25 commercial prescription ODTs used as samples, a good correlation was shown between the results of a human sensory test by five healthy male volunteers and the results using the KYO method. Furthermore, the KYO method could evaluate time-dependent changes in ODT samples. On the other hand, no correlation was observed between the Japanese Pharmacopeia disintegration test and the human sensory test. These results suggested that the KYO method reflected the disintegration nature of the ODTs in the oral cavity, and could easily be applied to development stages and the quality control field of ODT products.

  4. A method for calculating active feedback system to provide vertical ...

    Indian Academy of Sciences (India)

    Slow instabilities, development time of which is proportional to the .... where (w, I) denotes the scalar (inner or dot) product of vectors w and I. Solutions ... which the system of passive conductors must satisfy. ..... In this research, the active feedback system consisting of two coils with coordi- .... a new mode becomes dominant.

  5. A comparison of methods to determine tannin acyl hydrolase activity

    Directory of Open Access Journals (Sweden)

    Cristóbal Aguilar

    1999-01-01

    Full Text Available Six methods to determine the activity of tannase produced by Aspergillus niger Aa-20 on polyurethane foam by solid state fermentation, which included two titrimetric techniques, three spectrophotometric methods and one HPLC assay were tested and compared. All methods assayed enabled the measurement of extracellular tannase activity. However, only five were useful to evaluate intracellular tannase activity. Studies on the effect of pH on tannase extraction demonstrated that tannase activity was considerably under-estimated when its extraction was carried out at pH values below 5.5 and above 6.0. Results showed that the HPLC technique and the modified Bajpai and Patil methods presented several advantages in comparison to the other methods tested.Seis métodos para determinar a atividade de tannase produzida por Aspergillus niger O Aa-20 em espuma de polyuretano por fermentação em estado sólido foram estudados. Duas técnicas titulométricas , três métodos spectrofotométricos e um método por HPLC foram testados e comparados. Todos os métodos testados permitiram determinar a atividade da tannase produzida extracelularmente. Entretanto, somente cinco se mostraram úteis para avaliar a atividade da tannase produzida intracelularmente. Os estudos do efeito do pH na extração de tannase demonstraram que a atividade de tannase era consideravelmente subestimada quando sua extração foi executada em valores de pH inferiores a 5.5 e superior a pH 6.0. Os resultados demostraram que a técnica de HPLC o método Bajpai and Patil modificado apresentam várias vantagens em comparação aos outros métodos testados.

  6. DEVELOPING STUDENT SOCIALIZATION THROUGH MOTOR ACTIVITIES

    Directory of Open Access Journals (Sweden)

    Ioan Sabin SOPA

    2016-10-01

    Full Text Available : Starting from the assumption that motor activities are the perfect environment for socialization, communication and social integration of young people, this study aims to analyze the effectiveness of these activities in improving intergroup relations at the university level. In this research, the samples were composed of two groups, the experimental group (n = 25 with students from the Physical Education specialization and control group B (n = 25, composed of students from the Faculty of Sciences. The sociological survey applied on the two samples aimed to analyze the level of socialization, communication and social integration of students. The findings showed that the experimental group is more united, having a higher level of socialization and communication, compared to the control group B, proving once again the socializing effects of motor activities.

  7. A systematic review and appraisal of methods of developing and ...

    African Journals Online (AJOL)

    ) risk factors questionnaires is the key to obtaining accurate information to enable planning of CVD prevention program which is a necessity in developing countries. We conducted this review to assess methods and processes used for ...

  8. The development of water quality methods within ecological ...

    African Journals Online (AJOL)

    The development of water quality methods within ecological Reserve ... Water Act (NWA, No 36 of 1998), the ecological Reserve is defined as the quality and quantity ... provide ecologically important flow-related habitat, or geomorphological ...

  9. Development of digital image correlation method to analyse crack ...

    Indian Academy of Sciences (India)

    samples were performed to verify the performance of the digital image correlation method. ... development cannot be measured accurately. ..... Mendelson A 1983 Plasticity: Theory and application (USA: Krieger Publishing company Malabar,.

  10. New developments in the Csub(N) method

    International Nuclear Information System (INIS)

    Grandjean, Paul; Kavenoky, Alain.

    1975-01-01

    The most recent developments of the Csub(N) method used for solving transport equations are presented: treatment of the Rayleigh scattering kernel in plane geometry and of the cylindrical problems with an isotropic scattering law [fr

  11. Development of measure methods of radon in indoor air

    International Nuclear Information System (INIS)

    Yaginuma, L.T.; Pela, C.A.; Navas, E.A.; Ghilardi, A.J.P.

    1992-01-01

    The development of some conventional measuring methods, aiming obtain an estimation of radon concentration in air, mainly in indoor air is described, including the charcoal absorption collector, Lucas cell and thermoluminescent dosemeters. (C.G.C)

  12. Development of Analytical Method for Detection of Some ...

    African Journals Online (AJOL)

    All rights reserved. ... 3Centre for Water Research and Analysis (ALIR), Faculty of Science and Technology, Universiti Kebangsaan (UKM), ... Purpose: To develop and validate a simple method using solid – phase extraction along with liquid.

  13. Neutron activation analysis: A primary method of measurement

    Energy Technology Data Exchange (ETDEWEB)

    Greenberg, Robert R., E-mail: robert.greenberg@nist.gov [National Institute of Standards and Technology, Gaithersburg, MD 20899-8395 (United States); Bode, Peter, E-mail: p.bode@tudelft.nl [Delft University of Technology, Delft (Netherlands); De Nadai Fernandes, Elisabete A., E-mail: lis@cena.usp.br [Centro de Energia Nuclear na Agricultura, Universidade de Sao Paulo, Piracicaba, SP (Brazil)

    2011-03-15

    Neutron activation analysis (NAA), based on the comparator method, has the potential to fulfill the requirements of a primary ratio method as defined in 1998 by the Comite Consultatif pour la Quantite de Matiere - Metrologie en Chimie (CCQM, Consultative Committee on Amount of Substance - Metrology in Chemistry). This thesis is evidenced in this paper in three chapters by: demonstration that the method is fully physically and chemically understood; that a measurement equation can be written down in which the values of all parameters have dimensions in SI units and thus having the potential for metrological traceability to these units; that all contributions to uncertainty of measurement can be quantitatively evaluated, underpinning the metrological traceability; and that the performance of NAA in CCQM key-comparisons of trace elements in complex matrices between 2000 and 2007 is similar to the performance of Isotope Dilution Mass Spectrometry (IDMS), which had been formerly designated by the CCQM as a primary ratio method.

  14. Developing inspection strategies to support local activities

    DEFF Research Database (Denmark)

    Jensen, Per Langå

    2003-01-01

    An analysis of the Danish development in regulatory praxsis within occupational health and safety with a detailed description of Adapted Inspection.......An analysis of the Danish development in regulatory praxsis within occupational health and safety with a detailed description of Adapted Inspection....

  15. Suggestions on the Development of Safety Culture Assessment Method

    International Nuclear Information System (INIS)

    Choi, Young Sung; Choi, Kwang Sik; Kim, Woong Sik

    2006-01-01

    Several efforts have been made to assess safety culture of organization that operates nuclear power plants in Korea. The MOST and KINS played a major role to develop assessment methods and KHNP applied them to its NPPs. This paper explains the two methods developed by KINS briefly and presents the insights obtained from the two different applications. It concludes with some suggestions for safety culture assessment based on the insights

  16. Water Loss Management: Tools and Methods for Developing Countries

    OpenAIRE

    Mutikanga, H.E.

    2012-01-01

    Water utilities in developing countries are struggling to provide customers with a reliable level of service due to their peculiar water distribution characteristics including poorly zoned networks with irregular supply operating under restricted budgets. These unique conditions demand unique tools and methods for water loss control. Water loss management: Tools and Methods for Developing Countries provide a decision support toolbox (appropriate tools and methodologies) for assessing, quantif...

  17. The Unified Problem-Solving Method Development Language UPML

    OpenAIRE

    Fensel, Dieter; Motta, Enrico; van Harmelen, Frank; Benjamins, V. Richard; Crubezy, Monica; Decker, Stefan; Gaspari, Mauro; Groenboom, Rix; Grosso, William; Musen, Mark; Plaza, Enric; Schreiber, Guus; Studer, Rudi; Wielinga, Bob

    2003-01-01

    Problem-solving methods provide reusable architectures and components for implementing the reasoning part of knowledge-based systems. The UNIFIED PROBLEM-SOLVING METHOD DESCRIPTION LANGUAGE (UPML) has been developed to describe and implement such architectures and components to facilitate their semi-automatic reuse and adaptation. In a nutshell, UPML is a framework for developing knowledge-intensive reasoning systems based on libraries ofg eneric problem-solving components. The paper describe...

  18. Development and application of methods to characterize code uncertainty

    International Nuclear Information System (INIS)

    Wilson, G.E.; Burtt, J.D.; Case, G.S.; Einerson, J.J.; Hanson, R.G.

    1985-01-01

    The United States Nuclear Regulatory Commission sponsors both international and domestic studies to assess its safety analysis codes. The Commission staff intends to use the results of these studies to quantify the uncertainty of the codes with a statistically based analysis method. Development of the methodology is underway. The Idaho National Engineering Laboratory contributions to the early development effort, and testing of two candidate methods are the subjects of this paper

  19. Reaction kinetics, reaction products and compressive strength of ternary activators activated slag designed by Taguchi method

    NARCIS (Netherlands)

    Yuan, B.; Yu, Q.L.; Brouwers, H.J.H.

    2015-01-01

    This study investigates the reaction kinetics, the reaction products and the compressive strength of slag activated by ternary activators, namely waterglass, sodium hydroxide and sodium carbonate. Nine mixtures are designed by the Taguchi method considering the factors of sodium carbonate content

  20. Applied research and development of neutron activation analysis

    International Nuclear Information System (INIS)

    Chung, Yong Sam; Moon, Jong Hwa; Kim, Sun Ha; Baek, Sung Ryel; Kim, Young Gi; Jung, Hwan Sung; Park, Kwang Won; Kang, Sang Hun; Lim, Jong Myoung

    2003-05-01

    The aims of this project are to establish the quality control system of Neutron Activation Analysis(NAA) due to increase of industrial needs for standard analytical method and to prepare and identify the standard operation procedure of NAA through practical testing for different analytical items. R and D implementations of analytical quality system using neutron irradiation facility and gamma-ray measurement system and automation of NAA facility in HANARO research reactor are as following ; 1) Establishment of NAA quality control system for the maintenance of best measurement capability and the promotion of utilization of HANARO research reactor 2) Improvement of analytical sensitivity for industrial applied technologies and establishment of certified standard procedures 3) Standardization and development of Prompt Gamma-ray Activation Analysis (PGAA) technology

  1. Physical Activity and Adolescent Female Psychological Development.

    Science.gov (United States)

    Covey, Linda A.; Feltz, Deborah L.

    1991-01-01

    Relationships between self-reported past and present physical activity levels and self-image, sense of mastery, gender role identity, self-perceived physical ability, and self-perceived attractiveness were studied for 149 female high school sophomores, juniors, and seniors. Results are discussed in terms of adolescent emotional health. (SLD)

  2. Developing metacognition: a basis for active learning

    NARCIS (Netherlands)

    Vos, Henk; de Graaff, E.

    2004-01-01

    The reasons to introduce formats of Active Learning in Engineering (ALE) like project work, problem based learning, use of cases, etc., are mostly based on practical experience and sometimes from applied research on teaching and learning. Such research shows that students learn more and different

  3. On the Adaptation of an Agile Information Systems Development Method

    NARCIS (Netherlands)

    Aydin, M.N.; Harmsen, F.; van Slooten, C.; Stegwee, R.A.

    2005-01-01

    Little specific research has been conducted to date on the adaptation of agile information systems development (ISD) methods. This article presents the work practice in dealing with the adaptation of such a method in the ISD department of one of the leading financial institutes in Europe. Two forms

  4. Adaptation of an Agile Information System Development Method

    NARCIS (Netherlands)

    Aydin, M.N.; Harmsen, A.F.; van Hillegersberg, Jos; Stegwee, R.A.; Siau, K.

    2007-01-01

    Little specific research has been conducted to date on the adaptation of agile information systems development (ISD) methods. This chapter presents the work practice in dealing with the adaptation of such a method in the ISD department of one of the leading financial institutes in Europe. The

  5. Epistemological Development and Judgments and Reasoning about Teaching Methods

    Science.gov (United States)

    Spence, Sarah; Helwig, Charles C.

    2013-01-01

    Children's, adolescents', and adults' (N = 96 7-8, 10-11, and 13-14-year-olds and university students) epistemological development and its relation to judgments and reasoning about teaching methods was examined. The domain (scientific or moral), nature of the topic (controversial or noncontroversial), and teaching method (direct instruction by…

  6. Recent developments in analytical detection methods for radiation processed foods

    International Nuclear Information System (INIS)

    Wu Jilan

    1993-01-01

    A short summary of the programmes of 'ADMIT' (FAO/IAEA) and the developments in analytical detection methods for radiation processed foods has been given. It is suggested that for promoting the commercialization of radiation processed foods and controlling its quality, one must pay more attention to the study of analytical detection methods of irradiated food

  7. Development and validation of a spectroscopic method for the ...

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research ... Purpose: To develop a new analytical method for the quantitative analysis of miconazole ... a simple, reliable and robust method for the characterization of a mixture of the drugs in a dosage form. ... By Country · List All Titles · Free To Read Titles This Journal is Open Access.

  8. Methods of the Development Strategy of Service Companies: Logistical Approach

    Science.gov (United States)

    Toymentseva, Irina A.; Karpova, Natalya P.; Toymentseva, Angelina A.; Chichkina, Vera D.; Efanov, Andrey V.

    2016-01-01

    The urgency of the analyzed issue is due to lack of attention of heads of service companies to the theory and methodology of strategic management, methods and models of management decision-making in times of economic instability. The purpose of the article is to develop theoretical positions and methodical recommendations on the formation of the…

  9. Development and Validation of Improved Method for Fingerprint ...

    African Journals Online (AJOL)

    Purpose: To develop and validate an improved method by capillary zone electrophoresis with photodiode array detection for the fingerprint analysis of Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong). Methods: The optimum high performance capillary electrophoresis (HPCE) conditions were 30 mM borax containing 5 ...

  10. Development and Validation of a Bioanalytical Method for Direct ...

    African Journals Online (AJOL)

    Purpose: To develop and validate a user-friendly spiked plasma method for the extraction of diclofenac potassium that reduces the number of treatments with plasma sample, in order to minimize human error. Method: Instead of solvent evaporation technique, the spiked plasma sample was modified with H2SO4 and NaCl, ...

  11. USING ANALYTIC HIERARCHY PROCESS (AHP METHOD IN RURAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Tülay Cengiz

    2003-04-01

    Full Text Available Rural development is a body of economical and social policies towards improving living conditions in rural areas through enabling rural population to utilize economical, social, cultural and technological blessing of city life in place, without migrating. As it is understood from this description, rural development is a very broad concept. Therefore, in development efforts problem should be stated clearly, analyzed and many criterias should be evaluated by experts. Analytic Hierarchy Process (AHP method can be utilized at there stages of development efforts. AHP methods is one of multi-criteria decision method. After degrading a problem in smaller pieces, relative importance and level of importance of two compared elements are determined. It allows evaluation of quality and quantity factors. At the same time, it permits utilization of ideas of many experts and use them in decision process. Because mentioned features of AHP method, it could be used in rural development works. In this article, cultural factors, one of the important components of rural development is often ignored in many studies, were evaluated as an example. As a result of these applications and evaluations, it is concluded that AHP method could be helpful in rural development efforts.

  12. A Model-Driven Development Method for Management Information Systems

    Science.gov (United States)

    Mizuno, Tomoki; Matsumoto, Keinosuke; Mori, Naoki

    Traditionally, a Management Information System (MIS) has been developed without using formal methods. By the informal methods, the MIS is developed on its lifecycle without having any models. It causes many problems such as lack of the reliability of system design specifications. In order to overcome these problems, a model theory approach was proposed. The approach is based on an idea that a system can be modeled by automata and set theory. However, it is very difficult to generate automata of the system to be developed right from the start. On the other hand, there is a model-driven development method that can flexibly correspond to changes of business logics or implementing technologies. In the model-driven development, a system is modeled using a modeling language such as UML. This paper proposes a new development method for management information systems applying the model-driven development method to a component of the model theory approach. The experiment has shown that a reduced amount of efforts is more than 30% of all the efforts.

  13. Development of fatigue life evaluation method using small specimen

    International Nuclear Information System (INIS)

    Nogami, Shuhei; Nishimura, Arata; Wakai, Eichi; Tanigawa, Hiroyasu; Itoh, Takamoto; Hasegawa, Akira

    2013-01-01

    For developing the fatigue life evaluation method using small specimen, the effect of specimen size and shape on the fatigue life of the reduced activation ferritic/martensitic steels (F82H-IEA, F82H-BA07 and JLF-1) was investigated by the fatigue test at room temperature in air using round-bar and hourglass specimens with various specimen sizes (test section diameter: 0.85–10 mm). The round-bar specimen showed no specimen size and no specimen shape effects on the fatigue life, whereas the hourglass specimen showed no specimen size effect and obvious specimen shape effect on it. The shorter fatigue life of the hourglass specimen observed under low strain ranges could be attributed to the shorter micro-crack initiation life induced by the stress concentration dependent on the specimen shape. On the basis of this study, the small round-bar specimen was an acceptable candidate for evaluating the fatigue life using small specimen

  14. Method of oocyte activation affects cloning efficiency in pigs.

    Science.gov (United States)

    Whitworth, Kristin M; Li, Rongfeng; Spate, Lee D; Wax, David M; Rieke, August; Whyte, Jeffrey J; Manandhar, Gaurishankar; Sutovsky, Miriam; Green, Jonathan A; Sutovsky, Peter; Prather, Randall S

    2009-05-01

    The following experiments compared the efficiency of three fusion/activation protocols following somatic cell nuclear transfer (SCNT) with porcine somatic cells transfected with enhanced green fluorescent protein driven by the chicken beta-actin/rabbit beta-globin hybrid promoter (pCAGG-EGFP). The three protocols included electrical fusion/activation (NT1), electrical fusion/activation followed by treatment with a reversible proteasomal inhibitor MG132 (NT2) and electrical fusion in low Ca(2+) followed by chemical activation with thimerosal/dithiothreitol (NT3). Data were collected at Days 6, 12, 14, 30, and 114 of gestation. Fusion rates, blastocyst-stage mean cell numbers, recovery rates, and pregnancy rates were calculated and compared between protocols. Fusion rates were significantly higher for NT1 and NT2 compared to NT3 (P NT1 (71.4%, n = 28; P 0.05). All fusion/activation treatments produced live, pCAGG-EGFP positive piglets from SCNT. Treatment with MG132 after fusion/activation of reconstructed porcine embryos was the most effective method when comparing the overall pregnancy rates. The beneficial effect of NT2 protocol may be due to the stimulation of proteasomes that infiltrate donor cell nucleus shortly after nuclear transfer. (c) 2008 Wiley-Liss, Inc.

  15. Exploration Method Development for hydrothermal plume hunting by XCTD

    Science.gov (United States)

    Kitagawa, Y.; Ikeda, M.; Kadoshima, K.; Koizumi, Y.; Nakano, J.; Asakawa, E.; Sumi, T.

    2017-12-01

    J-MARES (Research and Development Partnership for Next Generation Technology of Marine Resources Survey, JAPAN) has been designing a low-cost and high-efficiency exploration system for seafloor hydrothermal massive sulfide deposits in "Cross-ministerial Strategic Innovation Promotion Program (SIP)" granted by the Cabinet Office, Government of Japan since 2014. We proposed hydrothermal plume hunting by XCTD (eXpendables Conductivity, Temperature and Depth). We applied this method to an area of interest more than 100km x 100km over Okinawa Trough, including some known seafloor massive sulfide deposits. Generally, hydrothermal plume exploration has been by ship mounted with MBES (Multi Beam Echo Sounder) or AUV with sound anomaly observation. However, these methods have to charter the sophisticated ship costly. On the other hand, throw-in type water quality meters (eg. XCTD and XBT) can be low-cost and easily operable. Moreover, that can make a quick look at seawater temperature and conductivity even in rough waters.Firstly, we confirmed XCTD probes position on the seafloor by ROV mounted deep-sea high vision camera. As a result of the test, probes swept downstream about 40 m in horizontal distance from throwing positions with about 1,600m in water depth. Following the previous test results, we had performed to the next test that confirmed detection range of hydrothermal plume at the chimney of North Mound in Izena Cauldron, so we had caught anomaly of seawater temperature and conductivity successfully which could be possibly derived from hydrothermal activities. Although averaged seawater temperature at a depth of 1500 m or more was about 3.95 degrees C, near the chimney was about 4.93 degrees C. The temperature anomalies originated from the hydrothermal plumes could be distributed at most 30m in horizontal distance and became smaller away from the chimney. Moreover, temperature anomaly mass of sea water tended to move upward in depth with distance away from the

  16. Development Of The Computer Code For Comparative Neutron Activation Analysis

    International Nuclear Information System (INIS)

    Purwadi, Mohammad Dhandhang

    2001-01-01

    The qualitative and quantitative chemical analysis with Neutron Activation Analysis (NAA) is an importance utilization of a nuclear research reactor, and this should be accelerated and promoted in application and its development to raise the utilization of the reactor. The application of Comparative NAA technique in GA Siwabessy Multi Purpose Reactor (RSG-GAS) needs special (not commercially available yet) soft wares for analyzing the spectrum of multiple elements in the analysis at once. The application carried out using a single spectrum software analyzer, and comparing each result manually. This method really degrades the quality of the analysis significantly. To solve the problem, a computer code was designed and developed for comparative NAA. Spectrum analysis in the code is carried out using a non-linear fitting method. Before the spectrum analyzed, it was passed to the numerical filter which improves the signal to noise ratio to do the deconvolution operation. The software was developed using the G language and named as PASAN-K The testing result of the developed software was benchmark with the IAEA spectrum and well operated with less than 10 % deviation

  17. Tracking maize pollen development by the Leaf Collar Method.

    Science.gov (United States)

    Begcy, Kevin; Dresselhaus, Thomas

    2017-12-01

    An easy and highly reproducible nondestructive method named the Leaf Collar Method is described to identify and characterize the different stages of pollen development in maize. In plants, many cellular events such as meiosis, asymmetric cell division, cell cycle regulation, cell fate determination, nucleus movement, vacuole formation, chromatin condensation and epigenetic modifications take place during pollen development. In maize, pollen development occurs in tassels that are confined within the internal stalk of the plant. Hence, identification of the different pollen developmental stages as a tool to investigate above biological processes is impossible without dissecting the entire plant. Therefore, an efficient and reproducible method is necessary to isolate homogeneous cell populations at individual stages throughout pollen development without destroying the plant. Here, we describe a method to identify the various stages of pollen development in maize. Using the Leaf Collar Method in the maize inbreed line B73, we have determined the duration of each stage from pollen mother cells before meiosis to mature tricellular pollen. Anther and tassel size as well as percentage of pollen stages were correlated with vegetative stages, which are easily recognized. The identification of stage-specific genes indicates the reproducibility of the method. In summary, we present an easy and highly reproducible nondestructive method to identify and characterize the different stages of pollen development in maize. This method now opens the way for many subsequent physiological, morphological and molecular analyses to study, for instance, transcriptomics, metabolomics, DNA methylation and chromatin patterns during normal and stressful conditions throughout pollen development in one of the economically most important grass species.

  18. A study of environmental polluting factors by neutron activation method

    International Nuclear Information System (INIS)

    Paunoiu, C.; Doca, C.

    2004-01-01

    The paper presents: a) some importance factors of the environmental pollution; b) the theoretical aspects of the Neutron Activation Analysis (NAA) used in the study of the environmental pollution; c) the NAA specific hardware and software facilities existing at the Institute for Nuclear Research; d) a direct application of the NAA method in the study of the environmental pollution for Pitesti city by the analysis of some ground and vegetation samples; e) results and conclusions. (authors)

  19. The Integral Method, a new approach to quantify bactericidal activity.

    Science.gov (United States)

    Gottardi, Waldemar; Pfleiderer, Jörg; Nagl, Markus

    2015-08-01

    The bactericidal activity (BA) of antimicrobial agents is generally derived from the results of killing assays. A reliable quantitative characterization and particularly a comparison of these substances, however, are impossible with this information. We here propose a new method that takes into account the course of the complete killing curve for assaying BA and that allows a clear-cut quantitative comparison of antimicrobial agents with only one number. The new Integral Method, based on the reciprocal area below the killing curve, reliably calculates an average BA [log10 CFU/min] and, by implementation of the agent's concentration C, the average specific bactericidal activity SBA=BA/C [log10 CFU/min/mM]. Based on experimental killing data, the pertaining BA and SBA values of exemplary active halogen compounds were established, allowing quantitative assertions. N-chlorotaurine (NCT), chloramine T (CAT), monochloramine (NH2Cl), and iodine (I2) showed extremely diverging SBA values of 0.0020±0.0005, 1.11±0.15, 3.49±0.22, and 291±137log10 CFU/min/mM, respectively, against Staphylococcus aureus. This immediately demonstrates an approximately 550-fold stronger activity of CAT, 1730-fold of NH2Cl, and 150,000-fold of I2 compared to NCT. The inferred quantitative assertions and conclusions prove the new method suitable for characterizing bactericidal activity. Its application comprises the effect of defined agents on various bacteria, the consequence of temperature shifts, the influence of varying drug structure, dose-effect relationships, ranking of isosteric agents, comparison of competing commercial antimicrobial formulations, and the effect of additives. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Evaluation index system of steel industry sustainable development based on entropy method and topsis method

    Science.gov (United States)

    Ronglian, Yuan; Mingye, Ai; Qiaona, Jia; Yuxuan, Liu

    2018-03-01

    Sustainable development is the only way for the development of human society. As an important part of the national economy, the steel industry is an energy-intensive industry and needs to go further for sustainable development. In this paper, we use entropy method and Topsis method to evaluate the development of China’s steel industry during the “12th Five-Year Plan” from four aspects: resource utilization efficiency, main energy and material consumption, pollution status and resource reuse rate. And we also put forward some suggestions for the development of China’s steel industry.

  1. APPLICATION OF QUALITY ECONOMY METHODS IN MANAGING INNOVATION CAPACITY DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    V. V. Okrepilov

    2017-01-01

    Full Text Available Purpose: to reveal the possibilities of applying the methods of the quality economy to improve the management efficiency of the development of the region's innovative potential.Results: in the article topical questions of development of innovative potential of the region are considered - one of the important factors providing improvement of quality of life of the population and sustainable development of the territory. The content of the concept of "innovation potential of the region" is disclosed and its components are described. The purposes of development of innovative potential are considered. A comparative analysis of the methods of managing the development of potential in the market and planned economy is carried out. Particular attention is paid to the application of quality management methods to improve management effectiveness. In conclusion, the advantages and disadvantages of the economy of the macro-region "North-West" from the point of view of transition to an innovative development path, as well as scenarios for the development of the economy, are discussed.Conclusions and relevance: the use of quality economy tools to manage the development of innovative capacity will help to avoid mistakes and choose the right directions for development. In the era of globalization, improving quality is a prerequisite for successful competition in world markets. Therefore, the issues of innovation capacity assessment should be taken into account in the development of regional plans and programs, as well as socio-economic policy.

  2. Development of 3-D FBR heterogeneous core calculation method based on characteristics method

    International Nuclear Information System (INIS)

    Takeda, Toshikazu; Maruyama, Manabu; Hamada, Yuzuru; Nishi, Hiroshi; Ishibashi, Junichi; Kitano, Akihiro

    2002-01-01

    A new 3-D transport calculation method taking into account the heterogeneity of fuel assemblies has been developed by combining the characteristics method and the nodal transport method. In the axial direction the nodal transport method is applied, and the characteristics method is applied to take into account the radial heterogeneity of fuel assemblies. The numerical calculations have been performed to verify 2-D radial calculations of FBR assemblies and partial core calculations. Results are compared with the reference Monte-Carlo calculations. A good agreement has been achieved. It is shown that the present method has an advantage in calculating reaction rates in a small region

  3. Development and Testing of Active Groundwater Samplers

    DEFF Research Database (Denmark)

    Nilsson, Bertel; Jakobsen, Rasmus; Andersen, Lars Jørgen

    1995-01-01

    Baffle System (PBS). The methodology and design of the two systems is presented and the operational application is demonstrated by examples from full-scale field experiments. The methods are validated and their sensitivity to the well construction and the hydrogeological environment is assessed based...

  4. A direction of developing a mining method and mining complexes

    Energy Technology Data Exchange (ETDEWEB)

    Gabov, V.V.; Efimov, I.A. [St. Petersburg State Mining Institute, St. Petersburg (Russian Federation). Vorkuta Branch

    1996-12-31

    The analyses of a mining method as a main factor determining the development stages of mining units is presented. The paper suggests a perspective mining method which differs from the known ones by following peculiarities: the direction selectivity of cuts with regard to coal seams structure; the cutting speed, thickness and succession of dusts. This method may be done by modulate complexes (a shield carrying a cutting head for coal mining), their mining devices being supplied with hydraulic drive. An experimental model of the module complex has been developed. 2 refs.

  5. Quality functions for requirements engineering in system development methods.

    Science.gov (United States)

    Johansson, M; Timpka, T

    1996-01-01

    Based on a grounded theory framework, this paper analyses the quality characteristics for methods to be used for requirements engineering in the development of medical decision support systems (MDSS). The results from a Quality Function Deployment (QFD) used to rank functions connected to user value and a focus group study were presented to a validation focus group. The focus group studies take advantage of a group process to collect data for further analyses. The results describe factors considered by the participants as important in the development of methods for requirements engineering in health care. Based on the findings, the content which, according to the user a MDSS method should support is established.

  6. A random spatial sampling method in a rural developing nation

    Science.gov (United States)

    Michelle C. Kondo; Kent D.W. Bream; Frances K. Barg; Charles C. Branas

    2014-01-01

    Nonrandom sampling of populations in developing nations has limitations and can inaccurately estimate health phenomena, especially among hard-to-reach populations such as rural residents. However, random sampling of rural populations in developing nations can be challenged by incomplete enumeration of the base population. We describe a stratified random sampling method...

  7. Do You Read Me? Service Supplement: Reading Development Activities Guide.

    Science.gov (United States)

    Kendall, Elizabeth L.; Chenoweth, Roberta

    This activity guide is one of four supplements to be used with "Do You Read Me? Prevocational-Vocational Reading Development Activities" (ED 210 454). Each supplement deals with a different occupational category. Games, puzzles, and other activities are offered to aid in developing the word recognition, vocabulary, and comprehension…

  8. Aeroelastic code development activities in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.D. [National Renewable Energy Lab., Golden, Colorado (United States)

    1996-09-01

    Designing wind turbines to be fatigue resistant and to have long lifetimes at minimal cost is a major goal of the federal wind program and the wind industry in the United States. To achieve this goal, we must be able to predict critical loads for a wide variety of different wind turbines operating under extreme conditions. The codes used for wind turbine dynamic analysis must be able to analyze a wide range of different wind turbine configurations as well as rapidly predict the loads due to turbulent wind inflow with a minimal set of degrees of freedom. Code development activities in the US have taken a two-pronged approach in order to satisfy both of these criteria: (1) development of a multi-purpose code which can be used to analyze a wide variety of wind turbine configurations without having to develop new equations of motion with each configuration change, and (2) development of specialized codes with minimal sets of specific degrees of freedom for analysis of two- and three-bladed horizontal axis wind turbines and calculation of machine loads due to turbulent inflow. In the first method we have adapted a commercial multi-body dynamics simulation package for wind turbine analysis. In the second approach we are developing specialized codes with limited degrees of freedom, usually specified in the modal domain. This paper will summarize progress to date in the development, validation, and application of these codes. (au) 13 refs.

  9. Specific activity measurement of 64Cu: A comparison of methods

    International Nuclear Information System (INIS)

    Mastren, Tara; Guthrie, James; Eisenbeis, Paul; Voller, Tom; Mebrahtu, Efrem; Robertson, J. David; Lapi, Suzanne E.

    2014-01-01

    Effective specific activity of 64 Cu (amount of radioactivity per µmol metal) is important in order to determine purity of a particular 64 Cu lot and to assist in optimization of the purification process. Metal impurities can affect effective specific activity and therefore it is important to have a simple method that can measure trace amounts of metals. This work shows that ion chromatography (IC) yields similar results to ICP mass spectrometry for copper, nickel and iron contaminants in 64 Cu production solutions. - Highlights: • Comparison of TETA titration, ICP mass spectrometry, and ion chromatography to measure specific activity. • Validates ion chromatography by using ICP mass spectrometry as the “gold standard”. • Shows different types and amounts of metal impurities present in 64 Cu

  10. Validation of a method for radionuclide activity optimize in SPECT

    International Nuclear Information System (INIS)

    Perez Diaz, M.; Diaz Rizo, O.; Lopez Diaz, A.; Estevez Aparicio, E.; Roque Diaz, R.

    2007-01-01

    A discriminant method for optimizing the activity administered in NM studies is validated by comparison with ROC curves. the method is tested in 21 SPECT, performed with a Cardiac phantom. Three different cold lesions (L1, L2 and L3) were placed in the myocardium-wall for each SPECT. Three activities (84 MBq, 37 MBq or 18.5 MBq) of Tc-99m diluted in water were used as background. The linear discriminant analysis was used to select the parameters that characterize image quality (Background-to-Lesion (B/L) and Signal-to-Noise (S/N) ratios). Two clusters with different image quality (p=0.021) were obtained following the selected variables. the first one involved the studies performed with 37 MBq and 84 MBq, and the second one included the studies with 18.5 MBq. the ratios B/L, B/L2 and B/L3 are the parameters capable to construct the function, with 100% of cases correctly classified into the clusters. The value of 37 MBq is the lowest tested activity for which good results for the B/Li variables were obtained,without significant differences from the results with 84 MBq (p>0.05). The result is coincident with the applied ROC-analysis. A correlation between both method of r=890 was obtained. (Author) 26 refs

  11. Recent development of the passive vibration control method

    Science.gov (United States)

    Ishida, Yukio

    2012-05-01

    This paper introduces new passive vibration suppression methods developed recently in our laboratory. First, two methods used to suppress steady-state resonances are explained. One is the improvement of the efficiency of a ball balancer. A simple method to eliminate the influence of friction of balls and to improve its efficiency is introduced. The other is an effective method that utilizes the discontinuous spring characteristics. Secondly, a method to eliminate unstable ranges in rotor systems is explained. Unstable ranges in an asymmetrical shaft, and in a hollow rotor partially filled with liquid, are eliminated by the discontinuous spring characteristics. Thirdly, a method to suppress self-excited oscillations is explained. Self-excited oscillations due to internal damping and rubbing are discussed. Finally, the methods of using a pendulum or roller type absorbers to suppress torsional vibrations are explained.

  12. Recently developed methods in neutral-particle transport calculations: overview

    International Nuclear Information System (INIS)

    Alcouffe, R.E.

    1982-01-01

    It has become increasingly apparent that successful, general methods for the solution of the neutral particle transport equation involve a close connection between the spatial-discretization method used and the source-acceleration method chosen. The first form of the transport equation, angular discretization which is discrete ordinates is considered as well as spatial discretization based upon a mesh arrangement. Characteristic methods are considered briefly in the context of future, desirable developments. The ideal spatial-discretization method is described as having the following attributes: (1) positive-positive boundary data yields a positive angular flux within the mesh including its boundaries; (2) satisfies the particle balance equation over the mesh, that is, the method is conservative; (3) possesses the diffusion limit independent of spatial mesh size, that is, for a linearly isotropic flux assumption, the transport differencing reduces to a suitable diffusion equation differencing; (4) the method is unconditionally acceleratable, i.e., for each mesh size, the method is unconditionally convergent with a source iteration acceleration. It is doubtful that a single method possesses all these attributes for a general problem. Some commonly used methods are outlined and their computational performance and usefulness are compared; recommendations for future development are detailed, which include practical computational considerations

  13. Application of Indenting Method for Calculation of Activation Energy

    International Nuclear Information System (INIS)

    Kim, Jong-Seog; Kim, Tae-Ryong

    2006-01-01

    For the calculation of activation energy of cable materials, we used to apply the break-elongation test in accordance with ASTM D412(Stand Test Methods for Rubber Properties in Tension). For the cable jacket and insulation which have regular thickness, break-elongation test had been preferred since it showed linear character in the activation energy curve. But, for the cable which has irregular thickness or rugged surface of cable inside, break-elongation test show scattered data which can not be used for the calculation of activation energy. It is not easy to prepare break-elongation specimen for the cable smaller than 13mm diameter in accordance with ASTM D412. In the cases of above, we sometime use TGA method which heat the specimen from 50 .deg. C to 700 .deg. C at heating rates of 10, 15, 20 .deg. C/min. But, TGA is suspected for the representative of natural aging in the plant since it measure the weight decreasing rate during burning which may have different aging mechanism with that of natural aging. To solve above problems, we investigated alternatives such as indenter test. Indenter test is very convenient since it does not ask for a special test specimen as the break-elongation test does. Regular surface of cable outside is the only requirement of indenter test. Experience of activation energy calculation by using the indenter test is described herein

  14. Harbourscape Aalborg - Design Based Methods in Waterfront Development

    DEFF Research Database (Denmark)

    Kiib, Hans

    2012-01-01

    How can city planners and developers gain knowledge and develop new sustainable concepts for water front developments? The waterfront is far too often threatened by new privatisation, lack of public access and bad architecture. And in a time where low growth rates and crises in the building...... industry is leaving great parts of the harbour as urban voids planners are in search of new tools for bridging the time gap until new projects can be a reality. This chapter presents the development of waterfront regeneration concepts that resulted from design based workshops, Harbourscape Aalborg in 2005...... and Performative Architecture Workshop in 2008, and evaluates the method and the thinking behind this. The design workshops provide different design-based development methods which can be tested with the purpose of developing new concepts for the relationship between the city and its harbour, and in addition...

  15. EFFECT OF DIFFERENT PHYSICAL ACTIVITY TRAINING METHODS ON OVERWEIGHT ADOLESCENTS

    Directory of Open Access Journals (Sweden)

    Shohreh Ghatrehsamani

    2010-11-01

    Full Text Available BACKGROUND: In view of the growing trend of obesity around the world, including in our country, and the effect of reduced physical activity in increasing the incidence of obesity and overweight in children and adolescents and limitations of families in providing transport for their children to attend exercise classes, as well as time limitations of students in taking part in these classes, accessing appropriate methods for presenting physical activity training seems essential.    METHODS: This non-pharmacological clinical trial was performed during six months from May to November 2007 on 105 children and adolescents aged 6-18 years with obesity, randomly assigned to 3 groups of thirty-five. Nutrition and treatment behavior were the same in all groups, but physical activity training in the first group was taking part in physical activity training classes twice a week, in the second group by providing a training CD, and in the third group via face-to-face training. Before and after the intervention, anthropometric indicators were measured and recorded.    RESULTS: Mean body mass index (BMI of participants in group attended physical activity training classes, and in the group undergone training with CD, after the interventions was significantly lower than that before the intervention.     CONCLUSION: Our findings demonstrated that training using CDs can also be effective in reducing BMI in overweight and obese children and adolescents as much as face-to-face education and participation in physical training classes. Extending such interventions can be effective at the community level.      Keywords: Children, adolescents, physical activity, education, obesity, treatment.

  16. Simple method for assembly of CRISPR synergistic activation mediator gRNA expression array.

    Science.gov (United States)

    Vad-Nielsen, Johan; Nielsen, Anders Lade; Luo, Yonglun

    2018-05-20

    When studying complex interconnected regulatory networks, effective methods for simultaneously manipulating multiple genes expression are paramount. Previously, we have developed a simple method for generation of an all-in-one CRISPR gRNA expression array. We here present a Golden Gate Assembly-based system of synergistic activation mediator (SAM) compatible CRISPR/dCas9 gRNA expression array for the simultaneous activation of multiple genes. Using this system, we demonstrated the simultaneous activation of the transcription factors, TWIST, SNAIL, SLUG, and ZEB1 a human breast cancer cell line. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. Application of neutron activation and high resolution X-ray spectrometry to the development of analytical methods suitable for the assay of trace elements in biological materials. Part of a coordinated programme on comparative methods for the study of trace elements in human nutrition

    International Nuclear Information System (INIS)

    Mantel, J.

    1980-12-01

    A new method for determining trace elements in biological materials by instrumental neutron activation analysis (INAA) has been investigated. This method is based on the measurement of low-energy X-rays emitted by the sample after appropriate activation with thermal neutrons. The X-rays were detected by a Si(Li) diode connected to a multichannel analyser. The background in the energy region of interest was reduced by means of an electromagnet which deflects high-energy beta-particles away from the detector. This method of measurement has been evaluated by application to a number of different biological reference materials. The use of the electromagnet for background reduction was shown to be extremely effective for several radionuclides that are common sources of disturbance in INAA. For 32 P the background was only 0.8% of its original value. For real samples the background reduction depends somewhat on the matrix and therefore varies from one material to another. Practical detection limits for typical biological materials were derived for 18 different trace elements. The use of a perspex absorber was also considered as an alternative to magnetic deflection of the beta rays. In practice, magnetic deflection is preferable for the lower-energy X-ray emitters such as the activation products of Co, Cr, Cu and Zn

  18. Extending product modeling methods for integrated product development

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hauksdóttir, Dagný

    2013-01-01

    Despite great efforts within the modeling domain, the majority of methods often address the uncommon design situation of an original product development. However, studies illustrate that development tasks are predominantly related to redesigning, improving, and extending already existing products...... and PVM methods, in a presented Product Requirement Development model some of the individual drawbacks of each method could be overcome. Based on the UML standard, the model enables the representation of complex hierarchical relationships in a generic product model. At the same time it uses matrix....... Updated design requirements have then to be made explicit and mapped against the existing product architecture. In this paper, existing methods are adapted and extended through linking updated requirements to suitable product models. By combining several established modeling techniques, such as the DSM...

  19. DEVELOPMENT OF A RISK SCREENING METHOD FOR CREDITED OPERATOR ACTIONS

    International Nuclear Information System (INIS)

    HIGGINS, J.C.; O'HARA, J.M.; LEWIS, P.M.; PERSENSKY, J.; BONGARRA, J.

    2002-01-01

    DEVELOPMENT OF A RISK SCREENING METHOD FOR CREDITED OPERATOR ACTIONS. THE U.S. NUCLEAR REGULATORY COMMISSION (NRC) REVIEWS THE HUMAN FACTORS ASPECTS OF PROPOSED LICENSE AMENDMENTS THAT IMPACT HUMAN ACTIONS THAT ARE CREDITED IN A PLANTS SAFETY ANALYSIS. THE STAFF IS COMMITTED TO A GRADED APPROACH TO THESE REVIEWS THAT FOCUS RESOURCES ON THE MOST RISK IMPORTANT CHANGES. THEREFORE, A RISK INFORMED SCREENING METHOD WAS DEVELOPED BASED ON AN ADAPTATION OF EXISTING GUIDANCE FOR RISK INFORMED REGULATION AND HUMAN FACTORS. THE METHOD USES BOTH QUANTITATIVE AND QUALITATIVE INFORMATION TO DIVIDE THE AMENDMENT REQUESTS INTO DIFFERENT LEVELS OF REVIEW. THE METHOD WAS EVALUATED USING A VARIETY OF TESTS. THIS PAPER WILL SUMMARIZE THE DEVELOPMENT OF THE METHODOLOGY AND THE EVALUATIONS THAT WERE PERFORMED TO VERIFY ITS USEFULNESS

  20. Overview of DOE's field screening technology development activities

    International Nuclear Information System (INIS)

    Frank, C.W.; Anderson, T.D.; Cooley, C.R.; Hain, K.E.; Lien, S.C.T.; Erickson, M.D.

    1991-01-01

    The Department of Energy (DOE) has recently created the Office of Environmental Restoration and Waste Management, into which it consolidated those activities. Within this new organization, the Office of Technology Development (OTD) is responsible for research, development, demonstration, testing, and evaluation (RDDT ampersand E) activities aimed at meeting DOE cleanup goals, while minimizing cost and risk. Site characterization using traditional drilling, sampling, and analytical methods comprises a significant part of the environmental restoration efforts in terms of both cost and time to accomplish. It can also be invasive and create additional pathways for spread of contaminants. Consequently, DOE is focusing on site characterization as one of the areas in which significant technological advances are possible which will decrease cost, reduce risk, and shorten schedules for achieving restoration goals. DOE is investing considerably in R ampersand D and demonstration activities which will improve the abilities to screen chemical, radiological, and physical parameters in the field. This paper presents an overview of the program objectives and status and reviews some of the projects which are currently underway in the area. 1 ref

  1. Software Development Methods and Tools: a New Zealand study

    OpenAIRE

    Chris Phillips; Elizabeth Kemp; Duncan Hedderley

    2005-01-01

    This study is a more detailed follow-up to a preliminary investigation of the practices of software engineers in New Zealand. The focus of this study is on the methods and tools used by software developers in their current organisation. The project involved detailed questionnaires being piloted and sent out to several hundred software developers. A central part of the research involved the identification of factors affecting the use and take-up of existing software development tools in the wo...

  2. Innovative Methods in Strategic Planning of Foreign Economic Activity of Enterprises

    Directory of Open Access Journals (Sweden)

    Valentyna Yakubiv

    2017-12-01

    Full Text Available Changes in the external conditions of business in Ukraine, European integration vector of the country development, and possibilities of import/export operations facilitate foreign trade. Modern methods of strategic management and strategic diagnostics should be developed in line with international requirements and needs of managers in Ukraine and partners abroad. Therefore substantiation of innovation trends for enterprise development strategies on the international arena as a constituent of stable economy is important and necessary. The purpose of this article is to define innovative approaches to planning, development and implementation of strategies and to develop a comprehensive diagnosis of the strategic potential of foreign economic activity. During the research, the following methods: logical abstraction, modeling, PEST-analysis, systems analysis, graphic. The main results of the study are: 1 disclosure of the features of the construction of strategic management in international business; 2 analysis of European and American practices of strategic management of foreign economic activity of enterprises; 3 study of algorithmic scheme of strategic management in the Ukraine; 4 justification of methods of three-level system of strategic analysis using matrix methods of assessment; 5 the classification of the main methods of matrix analysis within groups: macro, meso, macro level; 6 a comprehensive diagnosis of the strategic potential of foreign economic activity of enterprises in Ukraine. The study proved the main areas of innovation and strategic principles of international management and comprehensive methodology for strategic planning matrix based on innovative methods.

  3. Dynamical Systems Method and Applications Theoretical Developments and Numerical Examples

    CERN Document Server

    Ramm, Alexander G

    2012-01-01

    Demonstrates the application of DSM to solve a broad range of operator equations The dynamical systems method (DSM) is a powerful computational method for solving operator equations. With this book as their guide, readers will master the application of DSM to solve a variety of linear and nonlinear problems as well as ill-posed and well-posed problems. The authors offer a clear, step-by-step, systematic development of DSM that enables readers to grasp the method's underlying logic and its numerous applications. Dynamical Systems Method and Applications begins with a general introduction and

  4. Research and development of radioactive waste treatment methods

    International Nuclear Information System (INIS)

    Nguyen Thi Nang

    2000-01-01

    The Nuclear Research Institute (NRI) uses the reactor for research, training, isotope production and activation analyses. NRI generates about 150 m 3 of liquid and 5 m 3 of solid wastes every year. The researched methods applied to treatment of radwastes are coagulation-precipitation and two steps ion-exchange for liquid waste and compaction for solid waste are described. (author)

  5. One method of measure low activity level of α, β

    International Nuclear Information System (INIS)

    Sun Shimin

    2003-01-01

    In this paper it is described that several method of measure low activity level of Alpha and Beta, and an circuit diagram for signal of Alpha and Beta to differentiate with method of wave shape identification. With the method, the signal of Beta did not interfere any signal to the count-way of Alpha. For adopted the technology the model JA-3502 of eight detectors of low background Alpha and Beta measuring instrument only have 2.65 x 10 -4 cpm/cm 2 background count rate at count-way of Alpha. Opposite the model FJ-2600 middle area low background Alpha and Beta measuring instrument have 1.27 x 10 -3 cpm/cm 2 background count rate at count-way of Alpha. The latter is 5 times of other

  6. Cultural Change, Human Activity, and Cognitive Development

    Science.gov (United States)

    Gauvain, Mary; Munroe, Robert L.

    2012-01-01

    Differential cognitive performance across cultural contexts has been a standard result in comparative research. Here we discuss how societal changes occurring when a small-scale traditional community incorporates elements from industrialized society may contribute to cognitive development, and we illustrate this with an analysis of the cognitive…

  7. Linking Employee Development Activity, Social Exchange and Organizational Citizenship Behavior

    Science.gov (United States)

    Pierce, Heather R.; Maurer, Todd J.

    2009-01-01

    The authors examined "perceived beneficiary" of employee development (self, organization) for relationships with employee development activity. Perceived organizational support served as a moderator. The authors conclude that employees may engage in development activities to partly benefit their organization to the extent that a positive exchange…

  8. The J-Matrix Method Developments and Applications

    CERN Document Server

    Alhaidari, Abdulaziz D; Heller, Eric J; Abdelmonem, Mohamed S

    2008-01-01

    This volume aims to provide the fundamental knowledge to appreciate the advantages of the J-matrix method and to encourage its use and further development. The J-matrix method is an algebraic method of quantum scattering with substantial success in atomic and nuclear physics. The accuracy and convergence property of the method compares favourably with other successful scattering calculation methods. Despite its thirty-year long history new applications are being found for the J-matrix method. This book gives a brief account of the recent developments and some selected applications of the method in atomic and nuclear physics. New findings are reported in which experimental results are compared to theoretical calculations. Modifications, improvements and extensions of the method are discussed using the language of the J-matrix. The volume starts with a Foreword by the two co-founders of the method, E.J. Heller and H.A. Yamani and it contains contributions from 24 prominent international researchers.

  9. Teachers’ goal orientation profiles and participation in professional development activities

    NARCIS (Netherlands)

    Kunst, E.M.; van Woerkom, M.; Poell, R.F.

    2018-01-01

    Participation in professional development activities is important for teachers to continuously improve their knowledge and skills. However, teachers differ in their attitude towards learning activities. This paper examined how different goal orientation profiles are related to participation in

  10. Glutarimides: Biological activity, general synthetic methods and physicochemical properties

    Directory of Open Access Journals (Sweden)

    Popović-Đorđević Jelena B.

    2015-01-01

    Full Text Available Glutarimides, 2,6-dioxopiperidines are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics. Glutarimides act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antibacterials, and tumor suppressing agents. Some synthetic glutarimide derivatives are already in use as immunosuppressive and sedative (e.g., thalidomide or anxiolytics (buspirone drugs. The wide applicability of this class of compounds, justify the interest of scientists to explore new pathways for its syntheses. General methods for synthesis of six-membered imide ring, are presented in this paper. These methods include: a reaction of dicarboxylic acids with ammonia or primary amine, b reactions of cyclization: amido-acids, diamides, dinitriles, nitrilo-acids, amido-nitriles, amido-esters, amidoacyl-chlorides or diacyl-chlorides, c adition of carbon-monoxide on a,b-unsaturated amides, d oxidation reactions, e Michael adition of active methylen compounds on methacrylamide or conjugated amides. Some of the described methods are used for closing glutarimide ring in syntheses of farmacological active compounds sesbanimide and aldose reductase inhibitors (ARI. Analyses of the geometry, as well as, the spectroscopic analyses (NMR and FT-IR of some glutarimides are presented because of their broad spectrum of pharmacological activity. To elucidate structures of glutarimides, geometrical parameters of newly synthesized tert-pentyl-1-benzyl-4-methyl-glutarimide-3-carboxylate (PBMG are analyzed and compared with the experimental data from X-ray analysis for glutarimide. Moreover, molecular electrostatic potential (MEP surface which is plotted over the optimized geometry to elucidate the reactivity of PBMG molecule is analyzed. The electronic properties of glutarimide derivatives are explained on the example of thalidomide. The Frontier Molecular Orbital

  11. Developing knowledge management systems with an active expert methodology

    International Nuclear Information System (INIS)

    Sandahl, K.

    1992-01-01

    Knowledge management, understood as the ability to store, distribute and utilize human knowledge in an organization, is the subject of this dissertation. In particular we have studied the design of methods and supporting software for this process. Detailed and systematic description of the design and development processes of three case-study implementations of knowledge management software are provided. The outcome of the projects is explained in terms of an active expert development methodology, which is centered around support for a domain expert to take substantial responsibility for the design and maintenance of a knowledge management system in a given area of application. Based on the experiences from the case studies and the resulting methodology, an environment for automatically supporting knowledge management was designed in the KNOWLEDGE-LINKER research project. The vital part of this architecture is a knowledge acquisition tool, used directly by the experts in creating and maintaining a knowledge base. An elaborated version of the active expert development methodology was then formulated as the result of applying the KNOWLEDGE-LINKER approach in a fourth case study. This version of the methodology is also accounted for and evaluated together within the supporting KNOWLEDGE-LINKER architecture. (au)

  12. Development of Speaking Skills through Activity Based Learning at the Elementary Level

    Science.gov (United States)

    Ul-Haq, Zahoor; Khurram, Bushra Ahmed; Bangash, Arshad Khan

    2017-01-01

    Purpose: This paper discusses an effective instructional method called "activity based learning" that can be used to develop the speaking skills of students in the elementary school level. The present study was conducted to determine the effect of activity based learning on the development of the speaking skills of low and high achievers…

  13. Monitoring Student Activity in Collaborative Software Development

    DEFF Research Database (Denmark)

    Dietsch, Daniel; Podelski, Andreas; Nam, Jaechang

    2013-01-01

    year of studies formed 20 groups and worked collaboratively to develop video games. Throughout the lab, students have to use a variety of tools for managing and developing their projects, such as software version control, static analysis tools, wikis, mailing lists, etc. The students are also supported......This paper presents data analysis from a course on Software Engineering in an effort to identify metrics and techniques that would allow instructor to act proactively and identify patterns of low engagement and inefficient peer collaboration. Over the last two terms, 106 students in their second...... by weekly meetings with teaching assistants and instructors regarding group progress, code quality, and management issues. Through these meetings and their interactions with the software tools, students leave a detailed trace of data related to their individual engagement and their collaboration behavior...

  14. ANDRA activity and sustainable development report 2010

    International Nuclear Information System (INIS)

    2011-01-01

    After a presentation of the ANDRA (the French national agency for the management of radioactive wastes), and of the main actors of the management of radioactive wastes in France, this report indicates and comments actions performed by the ANDRA on its different sites, government decisions, projects, control operations, international cooperation, or information actions which occurred during 2010. These actions concern waste storage or recycling, research and development, storage sites and equipment, information actions or campaign

  15. Extravehicular Activity Technology Development Status and Forecast

    Science.gov (United States)

    Chullen, Cinda; Westheimer, David T.

    2011-01-01

    The goal of NASA s current EVA technology effort is to further develop technologies that will be used to demonstrate a robust EVA system that has application for a variety of future missions including microgravity and surface EVA. Overall the objectives will be to reduce system mass, reduce consumables and maintenance, increase EVA hardware robustness and life, increase crew member efficiency and autonomy, and enable rapid vehicle egress and ingress. Over the past several years, NASA realized a tremendous increase in EVA system development as part of the Exploration Technology Development Program and the Constellation Program. The evident demand for efficient and reliable EVA technologies, particularly regenerable technologies was apparent under these former programs and will continue to be needed as future mission opportunities arise. The technological need for EVA in space has been realized over the last several decades by the Gemini, Apollo, Skylab, Space Shuttle, and the International Space Station (ISS) programs. EVAs were critical to the success of these programs. Now with the ISS extension to 2028 in conjunction with a current forecasted need of at least eight EVAs per year, the EVA hardware life and limited availability of the Extravehicular Mobility Units (EMUs) will eventually become a critical issue. The current EMU has successfully served EVA demands by performing critical operations to assemble the ISS and provide repairs of satellites such as the Hubble Space Telescope. However, as the life of ISS and the vision for future mission opportunities are realized, a new EVA systems capability will be needed and the current architectures and technologies under development offer significant improvements over the current flight systems. In addition to ISS, potential mission applications include EVAs for missions to Near Earth Objects (NEO), Phobos, or future surface missions. Surface missions could include either exploration of the Moon or Mars. Providing an

  16. Exploring Techniques for Vision Based Human Activity Recognition: Methods, Systems, and Evaluation

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    2013-01-01

    Full Text Available With the wide applications of vision based intelligent systems, image and video analysis technologies have attracted the attention of researchers in the computer vision field. In image and video analysis, human activity recognition is an important research direction. By interpreting and understanding human activity, we can recognize and predict the occurrence of crimes and help the police or other agencies react immediately. In the past, a large number of papers have been published on human activity recognition in video and image sequences. In this paper, we provide a comprehensive survey of the recent development of the techniques, including methods, systems, and quantitative evaluation towards the performance of human activity recognition.

  17. Review of various dynamic modeling methods and development of an intuitive modeling method for dynamic systems

    International Nuclear Information System (INIS)

    Shin, Seung Ki; Seong, Poong Hyun

    2008-01-01

    Conventional static reliability analysis methods are inadequate for modeling dynamic interactions between components of a system. Various techniques such as dynamic fault tree, dynamic Bayesian networks, and dynamic reliability block diagrams have been proposed for modeling dynamic systems based on improvement of the conventional modeling methods. In this paper, we review these methods briefly and introduce dynamic nodes to the existing Reliability Graph with General Gates (RGGG) as an intuitive modeling method to model dynamic systems. For a quantitative analysis, we use a discrete-time method to convert an RGGG to an equivalent Bayesian network and develop a software tool for generation of probability tables

  18. Methodological developments and applications of neutron activation analysis

    International Nuclear Information System (INIS)

    Kucera, J.

    2007-01-01

    The paper reviews the author's experience acquired and achievements made in methodological developments of neutron activation analysis (NAA) of mostly biological materials. These involve epithermal neutron activation analysis, radiochemical neutron activation analysis using both single- and multi-element separation procedures, use of various counting modes, and the development and use of the self-verification principle. The role of NAA in the detection of analytical errors is discussed and examples of applications of the procedures developed are given. (author)

  19. A method to measure hydrolytic activity of adenosinetriphosphatases (ATPases.

    Directory of Open Access Journals (Sweden)

    Gianluca Bartolommei

    Full Text Available The detection of small amounts (nanomoles of inorganic phosphate has a great interest in biochemistry. In particular, phosphate detection is useful to evaluate the rate of hydrolysis of phosphatases, that are enzymes able to remove phosphate from their substrate by hydrolytic cleavage. The hydrolysis rate is correlated to enzyme activity, an extremely important functional parameter. Among phosphatases there are the cation transporting adenosinetriphosphatases (ATPases, that produce inorganic phosphate by cleavage of the γ-phosphate of ATP. These membrane transporters have many fundamental physiological roles and are emerging as potential drug targets. ATPase hydrolytic activity is measured to test enzyme functionality, but it also provides useful information on possible inhibitory effects of molecules that interfere with the hydrolytic process. We have optimized a molybdenum-based protocol that makes use of potassium antimony (III oxide tartrate (originally employed for phosphate detection in environmental analysis to allow its use with phosphatase enzymes. In particular, the method was successfully applied to native and recombinant ATPases to demonstrate its reliability, validity, sensitivity and versatility. Our method introduces significant improvements to well-established experimental assays, which are currently employed for ATPase activity measurements. Therefore, it may be valuable in biochemical and biomedical investigations of ATPase enzymes, in combination with more specific tests, as well as in high throughput drug screening.

  20. A gasometric method to determine erythrocyte catalase activity

    Directory of Open Access Journals (Sweden)

    A.J.S. Siqueira

    1999-09-01

    Full Text Available We describe a new gasometric method to determine erythrocyte catalase activity by the measurement of the volume of oxygen produced as a result of hydrogen peroxide decomposition in a system where enzyme and substrate are separated in a special reaction test tube connected to a manometer and the reagents are mixed with a motor-driven stirrer. The position of the reagents in the test tube permits the continuous measurement of oxygen evolution from the time of mixing, without the need to stop the reaction by the addition of acid after each incubation time. The enzyme activity is reported as KHb, i.e., mg hydrogen peroxide decomposed per second per gram of hemoglobin (s-1 g Hb-1. The value obtained for catalase activity in 28 samples of hemolyzed human blood was 94.4 ± 6.17 mg H2O2 s-1 g Hb-1. The results obtained were precise and consistent, indicating that this rapid, simple and inexpensive method could be useful for research and routine work.

  1. Assessment of active methods for removal of LEO debris

    Science.gov (United States)

    Hakima, Houman; Emami, M. Reza

    2018-03-01

    This paper investigates the applicability of five active methods for removal of large low Earth orbit debris. The removal methods, namely net, laser, electrodynamic tether, ion beam shepherd, and robotic arm, are selected based on a set of high-level space mission constraints. Mission level criteria are then utilized to assess the performance of each redirection method in light of the results obtained from a Monte Carlo simulation. The simulation provides an insight into the removal time, performance robustness, and propellant mass criteria for the targeted debris range. The remaining attributes are quantified based on the models provided in the literature, which take into account several important parameters pertaining to each removal method. The means of assigning attributes to each assessment criterion is discussed in detail. A systematic comparison is performed using two different assessment schemes: Analytical Hierarchy Process and utility-based approach. A third assessment technique, namely the potential-loss analysis, is utilized to highlight the effect of risks in each removal methods.

  2. Dosing method of physical activity in aerobics classes for students

    Directory of Open Access Journals (Sweden)

    Yu.I. Beliak

    2014-10-01

    Full Text Available Purpose : reasons for the method of dosing of physical activity in aerobics classes for students. The basis of the method is the evaluation of the metabolic cost of funds used in them. Material : experiment involved the assessment of the pulse response of students to load complexes classical and step aerobics (n = 47, age 20-23 years. In complexes used various factors regulating the intensity: perform combinations of basic steps, involvement of movements with his hands, holding in hands dumbbells weighing 1kg increase in the rate of musical accompaniment, varying heights step platform. Results . on the basis of the relationship between heart rate and oxygen consumption was determined by the energy cost of each admission control load intensity. This indicator has been used to justify the intensity and duration of multiplicity aerobics. Figure correspond to the level of physical condition and motor activity deficits students. Conclusions : the estimated component of this method of dosing load makes it convenient for use in automated computer programs. Also it can be easily modified to dispense load other types of recreational fitness.

  3. Designing a questionnaire on physical activity habits and lifestyle from the Delphi method

    Directory of Open Access Journals (Sweden)

    Estefanía Castillo Viera

    2012-02-01

    Full Text Available Nowadays there are numerous questionnaires studying physical activity habits, lifestyle and health (IPAQ, SF-36, EQ-5D. The problem arises when trying to design a new tool for use in a specific population that has specific characteristics and which seeks to explore aspects related to the area in which it develops. The main objective of this study was to design a questionnaire on physical activity and lifestyle of the university population. To prepare this Delphi method was used, a procedure based on expert consultation through a steering group and a group of experts to cast their opinions on a cyclical basis of the topic until they reach a consensus. In our case, a questionnaire was developed with seven dimensions and 55 items. The results lead us to make a positive assessment of the use of the Delphi method to design the questionnaire and ensuring greater validity.Key words: Physical activity habits, lifestyle, Delphi method.

  4. Development of motion image prediction method using principal component analysis

    International Nuclear Information System (INIS)

    Chhatkuli, Ritu Bhusal; Demachi, Kazuyuki; Kawai, Masaki; Sakakibara, Hiroshi; Kamiaka, Kazuma

    2012-01-01

    Respiratory motion can induce the limit in the accuracy of area irradiated during lung cancer radiation therapy. Many methods have been introduced to minimize the impact of healthy tissue irradiation due to the lung tumor motion. The purpose of this research is to develop an algorithm for the improvement of image guided radiation therapy by the prediction of motion images. We predict the motion images by using principal component analysis (PCA) and multi-channel singular spectral analysis (MSSA) method. The images/movies were successfully predicted and verified using the developed algorithm. With the proposed prediction method it is possible to forecast the tumor images over the next breathing period. The implementation of this method in real time is believed to be significant for higher level of tumor tracking including the detection of sudden abdominal changes during radiation therapy. (author)

  5. [Development and current situation of reconstruction methods following total sacrectomy].

    Science.gov (United States)

    Huang, Siyi; Ji, Tao; Guo, Wei

    2018-05-01

    To review the development of the reconstruction methods following total sacrectomy, and to provide reference for finding a better reconstruction method following total sacrectomy. The case reports and biomechanical and finite element studies of reconstruction following total sacrectomy at home and abroad were searched. Development and current situation were summarized. After developing for nearly 30 years, great progress has been made in the reconstruction concept and fixation techniques. The fixation methods can be summarized as the following three strategies: spinopelvic fixation (SPF), posterior pelvic ring fixation (PPRF), and anterior spinal column fixation (ASCF). SPF has undergone technical progress from intrapelvic rod and hook constructs to pedicle and iliac screw-rod systems. PPRF and ASCF could improve the stability of the reconstruction system. Reconstruction following total sacrectomy remains a challenge. Reconstruction combining SPF, PPRF, and ASCF is the developmental direction to achieve mechanical stability. How to gain biological fixation to improve the long-term stability is an urgent problem to be solved.

  6. Tooth Whitening And Temperature Rise With Two Bleaching Activation Methods

    International Nuclear Information System (INIS)

    Abu-ElMagd, D. M.; El-Sayad, I. I.; Abd El-Gawad, L. M.

    2009-01-01

    To measure the tooth whitening and the surface and Intrapulpal temperature increase in vitro on freshly extracted upper human central incisors after chemical, Zoom AP light and diode laser activated bleaching. Thirty caries-free upper human incisors were selected. Teeth were divided into three equal groups according to the methods of activation of the bleaching agent (n = 10). A whitening gel containing hydrogen peroxide was applied to the buccal surface of all teeth. Group I was bleached using chemically activated hydrogen peroxide gel, for three applications of 15 min each. Group II was bleached with high intensity advanced power Zoom activation light (Zoom AP), for three applications of 15 min each. Group III was bleached with diode laser activation technique, where the teeth were irradiated with 2 Watt diode laser for three applications of 30 sec each. The whitening degree was assessed using an image analysis system, while temperature rise was recorded using a thermocouple on the external tooth surface and Intrapulpal. The degree of whitening increased significantly in all groups. However, the percentage of whitening was not statistically significantly different between the three groups. In addition, group II showed statistically significant higher mean rise in both surface and pulp temperatures than group I and group III. Chemical bleaching produces the same whitening effect as Zoom AP light and laser, with no surface or pulpal temperature rise. Laser application is faster and produces less surface and pulp temperature increase than Zoom AP light. Diode laser used to activate bleaching gels is not considered dangerous to the vitality of dental pulp using power settings of 2 W.

  7. Method æ, the agile software development method tailored for the pharmaceutical industry.

    NARCIS (Netherlands)

    Hajou, A.; Batenburg, R.S.; Jansen, S.

    2015-01-01

    Agile software development methods have a high adoption rate due to their proven business benefits. Its success has not yet been identified in the pharmaceutical industry, due to the industry’s incompatibility with generic agile methods. Comprehensive research has been done to engineer a tailored

  8. Development of filters and housings for use on active plant

    International Nuclear Information System (INIS)

    Hackney, S.; Pratt, R.P.

    1983-01-01

    New designs of housings for conventional HEPA filters have been developed and are now in use. A further design is planned for future use. The main features to be developed are the engineering of double door systems to replace bag posting and other methods of filter changing which expose personnel to hazardous environments and the addition of a secondary containment to reduce the role of the gasket seal in the filtration efficiency. Also under development are circular geometry filters of HEPA standard which offer significant advantages over rectangular filters for applications requiring remote shielded change facilities. Two types of filter construction are being evaluated, conventional radial flow cartridge filters and spiral-wound, axial-flow filters. The application of circular filters for primary filter systems on active plant is in hand. A push-through change system has been developed for a new cell facility under construction at Harwell. Existing rectangular filters on a high activity cell are being replaced with clusters of small cartridge filters to overcome changing and disposal problems. A similar system but using 1700 m 3 /h filters for large volume off-gas treatment is also being studied. A remote change shielded filter installation is being developed for use in high alpha, beta, gamma extract systems. The design incorporates large cartridge filters in sealed drums with remote transfer and connection to duct work in the facility. A novel application of the use of double-lid technology removes the need for separate shut off dampers and enables the drums to be sealed for all transfer operations

  9. Analysis of cat oocyte activation methods for the generation of feline disease models by nuclear transfer

    Directory of Open Access Journals (Sweden)

    Herrick Jason R

    2009-12-01

    Full Text Available Abstract Background Somatic cell nuclear transfer in cats offers a useful tool for the generation of valuable research models. However, low birth rates after nuclear transfer hamper exploitation of the full potential of the technology. Poor embryo development after activation of the reconstructed oocytes seems to be responsible, at least in part, for the low efficiency. The objective of this study was to characterize the response of cat oocytes to various stimuli in order to fine-tune existing and possibly develop new activation methods for the generation of cat disease models by somatic cell nuclear transfer. Methods First, changes in the intracellular free calcium concentration [Ca2+]i in the oocytes induced by a number of artificial stimuli were characterized. The stimuli included electroporation, ethanol, ionomycin, thimerosal, strontium-chloride and sodium (Na+-free medium. The potential of the most promising treatments (with or without subsequent incubation in the presence of cycloheximide and cytochalasin B to stimulate oocyte activation and support development of the resultant parthenogenetic embryos was then evaluated. Finally, the most effective methods were selected to activate oocytes reconstructed during nuclear transfer with fibroblasts from mucopolysaccharidosis I- and alpha-mannosidosis-affected cats. Results All treatments were able to elicit a [Ca2+]i elevation in the ooplasm with various characteristics. Pronuclear formation and development up to the blastocyst stage was most efficiently triggered by electroporation (60.5 +/- 2.9 and 11.5 +/- 1.7% and the combined thimerosal/DTT treatment (67.7 +/- 1.8 and 10.6 +/- 1.9%; incubation of the stimulated oocytes with cycloheximide and cytochalasin B had a positive effect on embryo development. When these two methods were used to activate oocytes reconstructed during nuclear transfer, up to 84.9% of the reconstructed oocytes cleaved. When the 2 to 4-cell embryos (a total of 220 were

  10. A novel track density measurement method by thermal neutron activation of DYECETs

    International Nuclear Information System (INIS)

    Sohrabi, M.; Mahdi, Sh.

    1995-01-01

    A novel track density evaluation method based on thermal neutron activation of some elements of dyed electrochemically etched tracks (DYECETs) of charged particles in detectors like polycarbonate (PC) followed by measurements of gamma activity of the activated detectors is introduced. In this method, the tracks of charged particles like fast neutron-induced recoils in PC detectors were electrochemically etched, dyed by ''QuicDYECET'' methods as recently introduced by us, activated by thermal neutrons and counted for gamma activity determination to be correlated with track density. The activities of elements such as bromine-82 ( 82 Br) and sodium-24 ( 24 Na) on dyes such as Eosin Yellowish, Eosin Bluish, etc. determined by a hyper-pure germanium detector, were found to be in good correlation with DYECET density and thus particle fluence or dose. The effects of different types of dyes and their elements, dye concentration, neutron fluences and ECE durations on the DYECET density responses were studied. This new development is a method of scientific interest, potentially possessing some interesting features, as an alternative method for ECE track density determination using a gamma activity measuring system. It also has the drawback of being applicable only in centres having thermal neutron facilities. The results of the above studies are presented and discussed. (Author)

  11. Sensor Development for Active Flow Control

    Science.gov (United States)

    Kahng, Seun K.; Gorton, Susan A.; Mau, Johnney C.; Soto, Hector L.; Hernandez, Corey D.

    2001-01-01

    Presented are the developmental efforts for MEMS sensors for a closed-loop active flow control in a low-speed wind tunnel evaluation. The MEMS sensors are designed in-house and fabricated out of house, and the shear sensors are a thermal type that are collocated with temperature and pressure sensors on a flexible polyimide sheet, which conforms to surfaces of a simple curvature. A total of 6 sensors are located within a 1.5 by 3 mm area as a cluster with each sensor being 300 pm square. The thickness of this sensor cluster is 75 pm. Outputs from the shear sensors have been compared with respect to those of the Preston tube for evaluation of the sensors on a flat plate. Pressure sensors are the absolute type and have recorded pressure measurements within 0.05 percent of the tunnel ESP pressure sensor readings. The sensors and signal conditioning electronics have been tested on both a flat plate and a ramp in Langley s 15-Inch Low-Turbulence Tunnel. The system configuration and control PC is configured with LabView, where calibration constants are stored for desired compensation and correction. The preliminary test results are presented within.

  12. Determination of gold in lump by the gamma-activation analysis method

    International Nuclear Information System (INIS)

    Yantsen, V.A.; Ermakov, K.S.

    2006-01-01

    Full text: In the report the installation is described used in the Central gamma-activation analysis laboratory (CGAAL) for express quantitative determination of gold concentration in large powdered samples. The method of gold contents determination for non-crushed samples (pieces up to 100 mm). The given gamma-activation analysis method is widely used in mining industry, and at researches related with selection of optimal technological circuits designed for sorting the pieces of ore and rock materials. By developing this method it is now possible to create the technological collection of separated pieces by size, large by the amount of samples, imitating various sorts (by gold concentration in them) and types (by elemental composition) ores, and, based on these collection, to compare the efficiencies of various enrichment methods by knowing in advance the concentrations of gold in these lumps being the final sorting products. The Gamma-activation analysis method of large pieces is mainly used as foundation for the x-ray radiometric (XRR) method of pieces separation of gold-bearing ores from the deposits mined by the Navoi mining combine. It allows significant increase in the rate of research and development works on selection of the most reliable separation characteristics. Based on these one can develop optimal technological circuits for ore enrichment with portion sorting methods. (author)

  13. Recent Development in Rigorous Computational Methods in Dynamical Systems

    OpenAIRE

    Arai, Zin; Kokubu, Hiroshi; Pilarczyk, Paweł

    2009-01-01

    We highlight selected results of recent development in the area of rigorous computations which use interval arithmetic to analyse dynamical systems. We describe general ideas and selected details of different ways of approach and we provide specific sample applications to illustrate the effectiveness of these methods. The emphasis is put on a topological approach, which combined with rigorous calculations provides a broad range of new methods that yield mathematically rel...

  14. Developing methods of strip cropping cucumbers with rye/vetch

    OpenAIRE

    Ogutu, Maurice Okendo

    2000-01-01

    The purpose of this research carried out in 1998 and 1999 was to develop methods for strip cropping of cucumbers with rye/vetch and black plastic mulch. Effects of planting methods, weed control measures, and cover crop management techniques on pest and beneficial insects, petiole sap nitrate-nitrogen, soil moisture, yields and economic viability were assessed. Four treatments, namely cucumber direct seeded in black plastic mulch on tilled bare ground (conventional); cucumber d...

  15. Methods of measuring Protein Disulfide Isomerase activity: a critical overview

    Science.gov (United States)

    Watanabe, Monica; Laurindo, Francisco; Fernandes, Denise

    2014-09-01

    Protein disulfide isomerase is an essential redox chaperone from the endoplasmic reticulum (ER) and is responsible for correct disulfide bond formation in nascent proteins. PDI is also found in other cellular locations in the cell, particularly the cell surface. Overall, PDI contributes to ER and global cell redox homeostasis and signaling. The knowledge about PDI structure and function progressed substantially based on in vitro studies using recombinant PDI and chimeric proteins. In these experimental scenarios, PDI reductase and chaperone activities are readily approachable. In contrast, assays to measure PDI isomerase activity, the hallmark of PDI family, are more complex. Assessment of PDI roles in cells and tissues mainly relies on gain- or loss-of-function studies. However, there is limited information regarding correlation of experimental readouts with the distinct types of PDI activities. In this mini-review, we evaluate the main methods described for measuring the different kinds of PDI activity: thiol reductase, thiol oxidase, thiol isomerase and chaperone. We emphasize the need to use appropriate controls and the role of critical interferents (e.g., detergent, presence of reducing agents). We also discuss the translation of results from in vitro studies with purified recombinant PDI to cellular and tissue samples, with critical comments on the interpretation of results.

  16. A simple method for estimating the entropy of neural activity

    International Nuclear Information System (INIS)

    Berry II, Michael J; Tkačik, Gašper; Dubuis, Julien; Marre, Olivier; Da Silveira, Rava Azeredo

    2013-01-01

    The number of possible activity patterns in a population of neurons grows exponentially with the size of the population. Typical experiments explore only a tiny fraction of the large space of possible activity patterns in the case of populations with more than 10 or 20 neurons. It is thus impossible, in this undersampled regime, to estimate the probabilities with which most of the activity patterns occur. As a result, the corresponding entropy—which is a measure of the computational power of the neural population—cannot be estimated directly. We propose a simple scheme for estimating the entropy in the undersampled regime, which bounds its value from both below and above. The lower bound is the usual ‘naive’ entropy of the experimental frequencies. The upper bound results from a hybrid approximation of the entropy which makes use of the naive estimate, a maximum entropy fit, and a coverage adjustment. We apply our simple scheme to artificial data, in order to check their accuracy; we also compare its performance to those of several previously defined entropy estimators. We then apply it to actual measurements of neural activity in populations with up to 100 cells. Finally, we discuss the similarities and differences between the proposed simple estimation scheme and various earlier methods. (paper)

  17. Distinguishing method for contamination/radio-activation of radioactive wastes

    International Nuclear Information System (INIS)

    Fukazawa, Takuji; Kato, Keiichiro; Koda, Satoshi.

    1994-01-01

    The present invention concerns a method of distinguishing the contamination/radio-activation of radioactive wastes used in processing wastes generated upon dismantling of exhausted nuclear reactors. Especially, contaminated/radio-activation is distinguished for wastes having openings such as pipes and valves, by utilizing scattering of γ-rays or γ-ray to β-ray ratio. That is, ratio of scattered γ-rays and direct γ-rays or ratio of β-rays and γ-rays from radioactive wastes are measured and compared by a radiation detector, to distinguish whether the radioactive wastes contaminated materials or radio-activated materials. For example, when an object to be measured having an opening is contaminated at the inner side, the radiation detector facing to the opening mainly detects high direct γ-rays emitted from the object to be measured while a radiation detector not facing the opening mainly detects high scattered γ-rays relatively. On the other hand, when the object is a radio-activated material, any of the detectors detect scattered γ-rays, so that they can be distinguished by these ratios. (I.S.)

  18. Active children through incentive vouchers – evaluation (ACTIVE: a mixed-method feasibility study

    Directory of Open Access Journals (Sweden)

    Danielle Christian

    2016-08-01

    Full Text Available Abstract Background Adolescents face many barriers to physical activity, demonstrated by the decline in physical activity levels in teenage populations. This study aimed to assess the feasibility of overcoming such barriers via the implementation of an activity-promoting voucher scheme to teenagers in deprived areas. Methods All Year 9 pupils (n = 115; 13.3 ± 0.48 years; 51 % boys from one secondary school in Wales (UK participated. Participants received £25 of activity vouchers every month for six months for physical activity or sporting equipment. Focus groups (n = 7, with 43 pupils, and qualitative interviews with teachers (n = 2 were conducted to assess feasibility, in addition to a process evaluation utilising the RE-AIM framework. Quantitative outcomes at baseline, five months (during intervention and twelve months (follow-up included: physical activity (accelerometer, aerobic fitness (12 min Cooper run and self-reported activity (PAQ-A. Motivation to exercise (BREQ-2 was measured three months post-baseline and at follow-up. Results Qualitative findings showed that vouchers encouraged friends to socialise through activity, provided opportunities to access local activities that pupils normally could not afford, and engaged both those interested and disinterested in physical education. Improvements in weekend moderate-to-vigorous physical activity and reductions in sedentary behaviour were observed in both sexes. Boys’ fitness significantly improved during the voucher scheme. ‘Non-active’ pupils (those not meeting recommended guidelines of 60 mins∙day−1 and those with higher motivation to exercise had higher voucher use. Conclusions Adolescents, teachers and activity providers supported the voucher scheme and felt the vouchers enabled deprived adolescents to access more physical activity opportunities. Voucher usage was associated with improved attitudes to physical activity, increased socialisation with

  19. Analysis of medicinal plant extracts by neutron activation method

    International Nuclear Information System (INIS)

    Vaz, Sandra Muntz

    1995-01-01

    This dissertation has presented the results from analysis of medicinal plant extracts using neutron activation method. Instrumental neutron activation analysis was applied to the determination of the elements Al, Br, Ca, Ce, Cl, Cr, Cs, Fe, K, La, Mg, Mn, Na, Rb, Sb, Sc and Zn in medicinal extracts obtained from Achyrolcline satureoides DC, Casearia sylvestris, Centella asiatica, Citrus aurantium L., Solano lycocarpum, Solidago microglossa, Stryphnondedron barbatiman and Zingiber officinale R. plants. The elements Hg and Se were determined using radiochemical separation by means of retention of Se in HMD inorganic exchanger and solvent extraction of Hg by bismuth diethyl-dithiocarbamate solution. Precision and accuracy of the results have been evaluated by analysing reference materials. The therapeutic action of some elements found in plant extracts analyzed was briefly discussed

  20. Multi-objective Design Method for Hybrid Active Power Filter

    Science.gov (United States)

    Yu, Jingrong; Deng, Limin; Liu, Maoyun; Qiu, Zhifeng

    2017-10-01

    In this paper, a multi-objective optimal design for transformerless hybrid active power filter (HAPF) is proposed. The interactions between the active and passive circuits is analyzed, and by taking the interactions into consideration, a three-dimensional objective problem comprising of performance, efficiency and cost of HAPF system is formulated. To deal with the multiple constraints and the strong coupling characteristics of the optimization model, a novel constraint processing mechanism based on distance measurement and adaptive penalty function is presented. In order to improve the diversity of optimal solution and the local searching ability of the particle swarm optimization (PSO) algorithm, a chaotic mutation operator based on multistage neighborhood is proposed. The simulation results show that the optimums near the ordinate origin of the three-dimension space make better tradeoff among the performance, efficiency and cost of HAPF, and the experimental results of transformerless HAPF verify the effectiveness of the method for multi-objective optimization and design.

  1. Developing the Students’ English Speaking Ability Through Impromptu Speaking Method.

    Science.gov (United States)

    Lumettu, A.; Runtuwene, T. L.

    2018-01-01

    Having multi -purposes, English mastery has becomea necessary for us.Of the four language skills, speaking skill should get the first priority in English teaching and speaking skills development cannot be separated from listening.One communicative way of developing speaking skill is impromptu speaking,a method sudden speaking which depends only on experience and insight by applying spontaneity or improvisation. It is delivered based on the need of the moment of speaking using simple language.This research aims to know (1). Why impromptu speaking is necessary in teaching speaking? (2). How can impromptu speaking develop the students’ speaking skills.The method of this research is qualitative method and the techniques of data collection are: observation,interview and documentation. The results of data analysis using Correlation shows a strong relation between the students’ speaking ability and impromptu speaking method (r = 0.80).The research show that by using impromptu speaking method, the students are trained to interact faster naturally and spontaneously and enrich their vocabulary and general science to support speaking development through interview, speech, presentation, discussion and storytelling.

  2. Fusion material development program in the broader approach activities

    Energy Technology Data Exchange (ETDEWEB)

    Nishitani, T. [Directorates of Fusion Energy Research: Naka, Ibaraki, Japan Atomic Energy Agency, Naka, Ibaraki (Japan); Tanigawa, H.; Jitsukawa, S. [Japan Atomic Energy Agency, Tokai-mura, Naga-gun, Ibaraki-ken (Japan); Hayashi, K.; Takatsu, H. [Fusion Research and Development Directorate, Japan Momie Energy Agency, Ibaraki-ken (Japan); Yamanishi, T. [Tritium Process Laboratory, Japan Atomic Energy Research Institute, Tokai-mura, Ibaraki-ken (Japan); Tsuchiya, K. [Directorates of Fusion Energy Research, JAEA, Higashi-ibaraki-gun, Ibaraki-ken (Japan); MoIslang, A. [Forschungszentrum Karlsruhe GmbH, FZK, Karlsruhe (Germany); Baluc, N. [EPFL-Ecole Polytechnique Federale de Lausanne, Association Euratom-Confederation Suisse, UHD - CRPP, PPB, Lausanne (Switzerland); Pizzuto, A. [ENEA CR Frascat, Frascati (Italy); Hodgson, E.R. [CIEMAT-Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Association Euratom-CIEMAT, Madrid (Spain); Lasser, R.; Gasparotto, M. [EFDA CSU Garching (Germany)

    2007-07-01

    Full text of publication follows: The world fusion community is now launching construction of ITER, the first nuclear-grade fusion machine in the world. In parallel to the ITER program, Broader Approach (BA) activities are initiated by EU and Japan, mainly at Rokkasho BA site in Japan. The BA activities include the International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities (IFMIF-EVEDA), the International Fusion Energy Research Center (IFERC), and the Satellite Tokamak. IFERC consists of three sub project; a DEMO Design and R and D coordination Center, a Computational Simulation Center, and an ITER Remote Experimentation Center. Technical R and Ds mainly on fusion materials will be implemented as a part of the DEMO Design and R and D coordination Center. Based on the common interest of each party toward DEMO, R and Ds on a) reduced activation ferritic martensitic (RAFM) steels as a DEMO blanket structural material, SiCf/SiC composites, advanced tritium breeders and neutron multiplier for DEMO blankets, and Tritium Technology were selected and assessed by European and Japanese experts. In the R and D on the RAFM steels, the fabrication technology, techniques to incorporate the fracture/rupture properties of the irradiated materials, and methods to predict the deformation and fracture behaviors of structures under irradiation will be investigated. For SiCf/SiC composites, standard methods to evaluate high-temperature and life-time properties will be developed. Not only for SiCf/SiC but also related ceramics, physical and chemical properties such as He and H permeability and absorption will be investigated under irradiation. As the advanced tritium breeder R and D, Japan and EU plan to establish the production technique for advanced breeder pebbles of Li{sub 2}TiO{sub 3} and Li{sub 4}SiO{sub 4}, respectively. Also physical, chemical, and mechanical properties will be investigated for produced breeder pebbles. For the

  3. Development of ceramic glaze with photocatalytic activity

    International Nuclear Information System (INIS)

    Tezza, V.B.; Uggioni, E.; Carrera, A.A. Duran; Bernardin, A.M.

    2011-01-01

    Glazes were developed by adding anatase in commercial ceramic plates as an agent of photocatalysis. The glazes were coated on ceramic tiles, which were fired between 800 and 1000°C. The formulations were characterized (SEM, XRD), and the wettability was determined by measuring the water contact angle. The microstructural analysis (SEM) showed that the anatase particles can disperse properly in the glaze matrix. The X-ray diffraction shows that from 1000°C, the glaze becomes very reactive, and particles of anatase are transformed into titanite or rutile, depending on the glaze used. The determination of the contact angle shows the clear influence of the glaze type and sintering temperature on the wettability characteristics of the obtained layer. (author)

  4. Development of medical application methods using radiation. Radionuclide therapy

    International Nuclear Information System (INIS)

    Choi, Chang Woon; Lim, S. M.; Kim, E.H.; Woo, K. S.; Chung, W. S.; Lim, S. J.; Choi, T. H.; Hong, S. W.; Chung, H. Y.; No, W. C.; Oh, B. H.; Hong, H. J.

    1999-04-01

    In this project, we studied following subjects: 1. development of monoclonal antibodies and radiopharmaceuticals 2. clinical applications of radionuclide therapy 3. radioimmunoguided surgery 4. prevention of restenosis with intracoronary radiation. The results can be applied for the following objectives: 1) radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial. 2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research. 3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology

  5. Development of medical application methods using radiation. Radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang Woon; Lim, S. M.; Kim, E.H.; Woo, K. S.; Chung, W. S.; Lim, S. J.; Choi, T. H.; Hong, S. W.; Chung, H. Y.; No, W. C. [Korea Atomic Energy Research Institute. Korea Cancer Center Hospital, Seoul, (Korea, Republic of); Oh, B. H. [Seoul National University. Hospital, Seoul (Korea, Republic of); Hong, H. J. [Antibody Engineering Research Unit, Taejon (Korea, Republic of)

    1999-04-01

    In this project, we studied following subjects: 1. development of monoclonal antibodies and radiopharmaceuticals 2. clinical applications of radionuclide therapy 3. radioimmunoguided surgery 4. prevention of restenosis with intracoronary radiation. The results can be applied for the following objectives: (1) radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial. (2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research. (3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology.

  6. The variational nodal method: some history and recent activity

    International Nuclear Information System (INIS)

    Lewis, E.E.; Smith, M.A.; Palmiotti, G.

    2005-01-01

    The variational nodal method combines spherical harmonics expansions in angle with hybrid finite element techniques in space to obtain multigroup transport response matrix algorithms applicable to a wide variety of reactor physics problems. This survey briefly recounts the method's history and reviews its capabilities. Two methods for obtaining discretized equations in the form of response matrices are compared. The first is that contained the widely used VARIANT code, while the second incorporates more recently developed integral transport techniques into the variational nodal framework. The two approaches are combined with a finite sub-element formulation to treat heterogeneous nodes. Results are presented for application to a deep penetration problem and to an OECD benchmark consisting of LWR Mox fuel assemblies. Ongoing work is discussed. (authors)

  7. Methods for external event screening quantification: Risk Methods Integration and Evaluation Program (RMIEP) methods development

    International Nuclear Information System (INIS)

    Ravindra, M.K.; Banon, H.

    1992-07-01

    In this report, the scoping quantification procedures for external events in probabilistic risk assessments of nuclear power plants are described. External event analysis in a PRA has three important goals; (1) the analysis should be complete in that all events are considered; (2) by following some selected screening criteria, the more significant events are identified for detailed analysis; (3) the selected events are analyzed in depth by taking into account the unique features of the events: hazard, fragility of structures and equipment, external-event initiated accident sequences, etc. Based on the above goals, external event analysis may be considered as a three-stage process: Stage I: Identification and Initial Screening of External Events; Stage II: Bounding Analysis; Stage III: Detailed Risk Analysis. In the present report, first, a review of published PRAs is given to focus on the significance and treatment of external events in full-scope PRAs. Except for seismic, flooding, fire, and extreme wind events, the contributions of other external events to plant risk have been found to be negligible. Second, scoping methods for external events not covered in detail in the NRC's PRA Procedures Guide are provided. For this purpose, bounding analyses for transportation accidents, extreme winds and tornadoes, aircraft impacts, turbine missiles, and chemical release are described

  8. Antifungal activity of gold nanoparticles prepared by solvothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Tokeer, E-mail: tahmad3@jmi.ac.in [Nanochemistry Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025 (India); Wani, Irshad A.; Lone, Irfan H.; Ganguly, Aparna [Nanochemistry Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025 (India); Manzoor, Nikhat; Ahmad, Aijaz [Department of Biosciences, Jamia Millia Islamia, New Delhi 110025 (India); Ahmed, Jahangeer [Department of Chemistry, Michigan State University, East Lansing, MI 48824 (United States); Al-Shihri, Ayed S. [Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, P.O. Box 9004 (Saudi Arabia)

    2013-01-15

    Graphical abstract: Gold nanoparticles (7 and 15 nm) of very high surface area (329 and 269 m{sup 2}/g) have been successfully synthesized through solvothermal method by using tin chloride and sodium borohydride as reducing agents. As-prepared gold nanoparticles shows very excellent antifungal activity against Candida isolates and activity increases with decrease in the particle size. Display Omitted Highlights: ► Effect of reducing agents on the morphology of gold nanoparticles. ► Highly uniform and monodisperse gold nanoparticles (7 nm). ► Highest surface area of gold nanoparticles (329 m{sup 2/}g). ► Excellent antifungal activity of gold nanoparticles against Candida strains. -- Abstract: Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl{sub 2} and NaBH{sub 4} as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15 nm using SnCl{sub 2}, however, NaBH{sub 4} produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7 nm. A high surface area of 329 m{sup 2}/g for 7 nm and 269 m{sup 2}/g for 15 nm gold nanoparticles was observed. UV–vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7 nm sized gold nanoparticles restricting the transmembrane H{sup +} efflux of the Candida species than 15 nm sized gold nanoparticles.

  9. Antifungal activity of gold nanoparticles prepared by solvothermal method

    International Nuclear Information System (INIS)

    Ahmad, Tokeer; Wani, Irshad A.; Lone, Irfan H.; Ganguly, Aparna; Manzoor, Nikhat; Ahmad, Aijaz; Ahmed, Jahangeer; Al-Shihri, Ayed S.

    2013-01-01

    Graphical abstract: Gold nanoparticles (7 and 15 nm) of very high surface area (329 and 269 m 2 /g) have been successfully synthesized through solvothermal method by using tin chloride and sodium borohydride as reducing agents. As-prepared gold nanoparticles shows very excellent antifungal activity against Candida isolates and activity increases with decrease in the particle size. Display Omitted Highlights: ► Effect of reducing agents on the morphology of gold nanoparticles. ► Highly uniform and monodisperse gold nanoparticles (7 nm). ► Highest surface area of gold nanoparticles (329 m 2/ g). ► Excellent antifungal activity of gold nanoparticles against Candida strains. -- Abstract: Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl 2 and NaBH 4 as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15 nm using SnCl 2 , however, NaBH 4 produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7 nm. A high surface area of 329 m 2 /g for 7 nm and 269 m 2 /g for 15 nm gold nanoparticles was observed. UV–vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7 nm sized gold nanoparticles restricting the transmembrane H + efflux of the Candida species than 15 nm sized gold nanoparticles.

  10. Youth Involvement In Rural Development Activities In Ogba District ...

    African Journals Online (AJOL)

    . This is because they are major stakeholders in the development process. This study investigates youth involvement in rural development activities in Ogba district of Rivers state, Nigeria. Data was collected from 120 randomly selected youths ...

  11. Changes in acetylcholinesterase activities in the developing and ...

    African Journals Online (AJOL)

    Changes in acetylcholinesterase activities in the developing and aging pig brain and hypophyses. ... International Journal of Agriculture and Rural Development. Journal Home · ABOUT ... Open Access DOWNLOAD FULL TEXT Subscription ...

  12. Compositions and methods for adoptive and active immunotherapy

    Science.gov (United States)

    Fahmy, Tarek; Steenblock, Erin

    2014-01-14

    Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.

  13. Alpha emitters activity measurement using the defined solid angle method

    International Nuclear Information System (INIS)

    Blanchis, P.

    1983-01-01

    The defined solid angle counting method can reach a very high accuracy, specially for heavy ions as alpha particles emitted by a radioactive source. The activity measurement of such sources with a relative uncertainty of the order of 0.01% is investigated. Such an accuracy is available only under suitable conditions: the radiation emitted by the source must be isotropic and all the particles emitted in the effective solid angle must be detected. The efficiency detection value must be equal to unity and phenomena such as absorption or scattering must be null. It is shown that corrections often become necessary. All parameters which can influence the measurements are studied [fr

  14. International intercomparison of neutron spectra evaluating methods using activation detectors

    International Nuclear Information System (INIS)

    Fischer, A.

    1975-06-01

    The international intercomparison of neutron spectrum evaluation methods using activation detectors was organized by the IAEA in 1971 - 1972. All of the contributions and the results of a critical evaluation are presented here. The spectra of different contributors are compared to a reference spectrum by means of different integrals and weighting functions. Different cross section sets, foil numbers, energy point systems, guess spectra used by the contributors cause differences in the resulting spectra. The possible ways of separating these effects are also investigated. Suggestions are made for the organization of a new intercomparison on the basis of more uniform input data. (orig.) [de

  15. Steam dealkylation catalyst and a method for its activation

    International Nuclear Information System (INIS)

    Dorawala, T.; Reinhard, R.

    1980-01-01

    The method of activating a supported catalyst containing oxides of a group viii metal and of a group 1 a metal which comprises heating said catalyst at a rate of 10 0 to 500 0 F/hr to a temperature of 650 0 to 1400 0 F in a hydrogen atmosphere; maintaining said heated catalyst in a hydrogen atmosphere at 650 0 to 1400 0 F for 2 to 30 hours thereby forming a hydrogen-treated catalyst; and maintaining the hydrogen-treated catalyst in a steam-hydrogen atmosphere at 650 0 to 1400 0 F for 2 to 20 hours thereby forming a steamed hydrogen-treated catalyst

  16. Development of a general method for photovoltaic system analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nolay, P

    1987-01-01

    The photovoltaic conversion for energetic applications is now widely used, but its development still needs the resolution of many problems for the sizing and for the real working of the installations. The precise analysis of the components and whole system behaviour has led to the development of accurate models for the simulation of such systems. From this modelling phase, a simulation code has been built. The validation of this software has been achieved from experimental test measurements. Since the quality of the software depends on the precision of the input data, an original method of determination of component characteristics, by means of model identification, has been developed. These tools permit the prediction of system behaviour and the dynamic simulation of systems under real conditions. Used for the study of photovoltaic system sizing, this software has allowed the definition of new concepts which will serve as a basis for the development of a sizing method.

  17. Developing an Engineering Design Process Assessment using Mixed Methods.

    Science.gov (United States)

    Wind, Stefanie A; Alemdar, Meltem; Lingle, Jeremy A; Gale, Jessica D; Moore, Roxanne A

    Recent reforms in science education worldwide include an emphasis on engineering design as a key component of student proficiency in the Science, Technology, Engineering, and Mathematics disciplines. However, relatively little attention has been directed to the development of psychometrically sound assessments for engineering. This study demonstrates the use of mixed methods to guide the development and revision of K-12 Engineering Design Process (EDP) assessment items. Using results from a middle-school EDP assessment, this study illustrates the combination of quantitative and qualitative techniques to inform item development and revisions. Overall conclusions suggest that the combination of quantitative and qualitative evidence provides an in-depth picture of item quality that can be used to inform the revision and development of EDP assessment items. Researchers and practitioners can use the methods illustrated here to gather validity evidence to support the interpretation and use of new and existing assessments.

  18. Methods for Developing Emissions Scenarios for Integrated Assessment Models

    Energy Technology Data Exchange (ETDEWEB)

    Prinn, Ronald [MIT; Webster, Mort [MIT

    2007-08-20

    The overall objective of this research was to contribute data and methods to support the future development of new emissions scenarios for integrated assessment of climate change. Specifically, this research had two main objectives: 1. Use historical data on economic growth and energy efficiency changes, and develop probability density functions (PDFs) for the appropriate parameters for two or three commonly used integrated assessment models. 2. Using the parameter distributions developed through the first task and previous work, we will develop methods of designing multi-gas emission scenarios that usefully span the joint uncertainty space in a small number of scenarios. Results on the autonomous energy efficiency improvement (AEEI) parameter are summarized, an uncertainty analysis of elasticities of substitution is described, and the probabilistic emissions scenario approach is presented.

  19. Development of inelastic design method for liquid metal reactor plants

    International Nuclear Information System (INIS)

    Takahashi, Yukio; Take, Kohji; Kaguchi, Hitoshi; Fukuda, Yoshio; Uno, Tetsuro.

    1991-01-01

    Effective utilization of inelastic analysis in structural design assessment is expected to play an important role for avoiding too conservative design of liquid metal reactor plants. Studies have been conducted by the authors to develop a guideline for application of detailed inelastic analysis in design assessment. Both fundamental material characteristics tests and structural failure tests were conducted. Fundamental investigations were made on inelastic analysis method and creep-fatigue life prediction method based on the results of material characteristics tests. It was demonstrated through structural failure tests that the design method constructed based on these fundamental investigations can predict failure lives in structures subjected to cyclic thermal loadings with sufficient accuracy. (author)

  20. Development of new HRA methods based upon operational experience

    International Nuclear Information System (INIS)

    Cooper, S.E.; Luckas, W.J.; Barriere, M.T.; Wreathall, J.

    2004-01-01

    Under the auspices of the US Nuclear Regulatory Commission (NRC), previously unaddressed human reliability issues are being investigated in order to support the development of human reliability analysis (HRA) methods for both low power and shutdown (LP and S) and full-power conditions. Actual operational experience, such as that reported in Licensee Event Reports (LERs), have been used to gain insights and provide a basis for the requirements of new HRA methods. In particular, operational experience has shown that new HRA methods for LP and S must address human-induced initiators, errors of commission, mistakes (vs. slips), dependencies, and the effects of multiple performance shaping factors (PSFs). (author)